Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA005376-TA|BGIBMGA005376-PA|IPR001873|Na+ channel,
amiloride-sensitive
(509 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U57352-1|AAB49182.1| 512|Homo sapiens sodium channel 1 protein. 52 5e-06
U53212-1|AAC50498.1| 512|Homo sapiens degenerin channel MDEG pr... 52 5e-06
U50352-1|AAC50432.1| 512|Homo sapiens sodium channel 1 protein. 52 5e-06
BC075043-1|AAH75043.1| 512|Homo sapiens amiloride-sensitive cat... 52 5e-06
BC075042-1|AAH75042.1| 512|Homo sapiens amiloride-sensitive cat... 52 5e-06
BC010439-1|AAH10439.1| 647|Homo sapiens amiloride-sensitive cat... 47 1e-04
BC073912-1|AAH73912.1| 296|Homo sapiens ACCN4 protein protein. 46 2e-04
U78181-1|AAB48981.1| 528|Homo sapiens sodium channel 2 protein. 46 4e-04
BC133707-1|AAI33708.1| 528|Homo sapiens amiloride-sensitive cat... 46 4e-04
AJ408881-1|CAC51338.1| 539|Homo sapiens acid sensing ion channe... 45 6e-04
AJ271643-1|CAB93980.1| 539|Homo sapiens putative acid-sensing i... 45 6e-04
AJ252011-1|CAB85607.1| 505|Homo sapiens amiloride-sensitive sod... 38 0.063
X87159-1|CAA60632.1| 640|Homo sapiens epithelial amiloride-sens... 36 0.34
L36593-1|AAA75459.1| 640|Homo sapiens epithelial sodium channel... 36 0.34
BC036352-1|AAH36352.2| 640|Homo sapiens sodium channel, nonvolt... 36 0.34
AJ005383-1|CAA06508.2| 640|Homo sapiens ENaCB, amiloride sensit... 36 0.34
BC036538-1|AAH36538.1| 425|Homo sapiens synaptotagmin IV protein. 34 1.4
AF299075-1|AAG37229.1| 425|Homo sapiens synaptotagmin IV protein. 34 1.4
AB037763-1|BAA92580.1| 426|Homo sapiens KIAA1342 protein protein. 34 1.4
U78180-1|AAB48980.1| 574|Homo sapiens sodium channel 2 protein. 33 1.8
AF195025-1|AAF19818.1| 549|Homo sapiens acid sensing ion channe... 33 3.2
AF195024-1|AAF19817.1| 543|Homo sapiens acid sensing ion channe... 33 3.2
AF095897-1|AAC64188.1| 531|Homo sapiens proton-gated cation cha... 33 3.2
AF057711-1|AAC62935.1| 531|Homo sapiens proton-gated cation cha... 33 3.2
AB010575-1|BAA25897.1| 532|Homo sapiens sodium channel protein. 33 3.2
BC013891-1|AAH13891.2| 344|Homo sapiens ACCN2 protein protein. 32 4.2
BC001107-1|AAH01107.1| 183|Homo sapiens FUS interacting protein... 31 7.3
AY150181-1|AAN65381.1| 183|Homo sapiens splicing factor SRp38-2... 31 7.3
AY048592-1|AAL06098.1| 183|Homo sapiens TLS-associated SR prote... 31 7.3
AL590609-5|CAI14803.1| 183|Homo sapiens FUS interacting protein... 31 7.3
AK001286-1|BAA91601.1| 183|Homo sapiens protein ( Homo sapiens ... 31 7.3
AF419331-1|AAL16665.1| 183|Homo sapiens TLS-associated protein ... 31 7.3
AF047448-1|AAC70918.1| 183|Homo sapiens TLS-associated protein ... 31 7.3
>U57352-1|AAB49182.1| 512|Homo sapiens sodium channel 1 protein.
Length = 512
Score = 52.0 bits (119), Expect = 5e-06
Identities = 50/192 (26%), Positives = 81/192 (42%), Gaps = 15/192 (7%)
Query: 280 IAPEKRKCRYNDENFLDVYRHYSYTACTVQCRKDAQMRFCNCSNYFMPN-----VPE-HL 333
+ P +CR + E LD + YS TAC + C + CNC MP PE H
Sbjct: 282 LPPPWGECR-SSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHK 340
Query: 334 KCNVSGIICLNNYVNILTVLKAPWS---SRPGLYCNCLPSCTESEI--SVINDLKDATAE 388
+C + L + + + P + L +PS T ++ N + +E
Sbjct: 341 ECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISE 400
Query: 389 DYATVEIELAMLPSERYRRNVVRGILDLVVSTGGTGGLFLGASILSFVEL---LYILLIR 445
+ ++I L E + + L+ GG GLF+GASIL+ +EL +Y L+
Sbjct: 401 NILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKE 460
Query: 446 PFCDIYSQREDD 457
D+ + ED+
Sbjct: 461 KLLDLLGKEEDE 472
>U53212-1|AAC50498.1| 512|Homo sapiens degenerin channel MDEG
protein.
Length = 512
Score = 52.0 bits (119), Expect = 5e-06
Identities = 50/192 (26%), Positives = 81/192 (42%), Gaps = 15/192 (7%)
Query: 280 IAPEKRKCRYNDENFLDVYRHYSYTACTVQCRKDAQMRFCNCSNYFMPN-----VPE-HL 333
+ P +CR + E LD + YS TAC + C + CNC MP PE H
Sbjct: 282 LPPPWGECR-SSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHK 340
Query: 334 KCNVSGIICLNNYVNILTVLKAPWS---SRPGLYCNCLPSCTESEI--SVINDLKDATAE 388
+C + L + + + P + L +PS T ++ N + +E
Sbjct: 341 ECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISE 400
Query: 389 DYATVEIELAMLPSERYRRNVVRGILDLVVSTGGTGGLFLGASILSFVEL---LYILLIR 445
+ ++I L E + + L+ GG GLF+GASIL+ +EL +Y L+
Sbjct: 401 NILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKE 460
Query: 446 PFCDIYSQREDD 457
D+ + ED+
Sbjct: 461 KLLDLLGKEEDE 472
>U50352-1|AAC50432.1| 512|Homo sapiens sodium channel 1 protein.
Length = 512
Score = 52.0 bits (119), Expect = 5e-06
Identities = 50/192 (26%), Positives = 81/192 (42%), Gaps = 15/192 (7%)
Query: 280 IAPEKRKCRYNDENFLDVYRHYSYTACTVQCRKDAQMRFCNCSNYFMPN-----VPE-HL 333
+ P +CR + E LD + YS TAC + C + CNC MP PE H
Sbjct: 282 LPPPWGECR-SSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHK 340
Query: 334 KCNVSGIICLNNYVNILTVLKAPWS---SRPGLYCNCLPSCTESEI--SVINDLKDATAE 388
+C + L + + + P + L +PS T ++ N + +E
Sbjct: 341 ECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISE 400
Query: 389 DYATVEIELAMLPSERYRRNVVRGILDLVVSTGGTGGLFLGASILSFVEL---LYILLIR 445
+ ++I L E + + L+ GG GLF+GASIL+ +EL +Y L+
Sbjct: 401 NILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKE 460
Query: 446 PFCDIYSQREDD 457
D+ + ED+
Sbjct: 461 KLLDLLGKEEDE 472
>BC075043-1|AAH75043.1| 512|Homo sapiens amiloride-sensitive cation
channel 1, neuronal (degenerin), isoform 2 protein.
Length = 512
Score = 52.0 bits (119), Expect = 5e-06
Identities = 50/192 (26%), Positives = 81/192 (42%), Gaps = 15/192 (7%)
Query: 280 IAPEKRKCRYNDENFLDVYRHYSYTACTVQCRKDAQMRFCNCSNYFMPN-----VPE-HL 333
+ P +CR + E LD + YS TAC + C + CNC MP PE H
Sbjct: 282 LPPPWGECR-SSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHK 340
Query: 334 KCNVSGIICLNNYVNILTVLKAPWS---SRPGLYCNCLPSCTESEI--SVINDLKDATAE 388
+C + L + + + P + L +PS T ++ N + +E
Sbjct: 341 ECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISE 400
Query: 389 DYATVEIELAMLPSERYRRNVVRGILDLVVSTGGTGGLFLGASILSFVEL---LYILLIR 445
+ ++I L E + + L+ GG GLF+GASIL+ +EL +Y L+
Sbjct: 401 NILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKE 460
Query: 446 PFCDIYSQREDD 457
D+ + ED+
Sbjct: 461 KLLDLLGKEEDE 472
>BC075042-1|AAH75042.1| 512|Homo sapiens amiloride-sensitive cation
channel 1, neuronal (degenerin) protein.
Length = 512
Score = 52.0 bits (119), Expect = 5e-06
Identities = 50/192 (26%), Positives = 81/192 (42%), Gaps = 15/192 (7%)
Query: 280 IAPEKRKCRYNDENFLDVYRHYSYTACTVQCRKDAQMRFCNCSNYFMPN-----VPE-HL 333
+ P +CR + E LD + YS TAC + C + CNC MP PE H
Sbjct: 282 LPPPWGECR-SSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHK 340
Query: 334 KCNVSGIICLNNYVNILTVLKAPWS---SRPGLYCNCLPSCTESEI--SVINDLKDATAE 388
+C + L + + + P + L +PS T ++ N + +E
Sbjct: 341 ECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISE 400
Query: 389 DYATVEIELAMLPSERYRRNVVRGILDLVVSTGGTGGLFLGASILSFVEL---LYILLIR 445
+ ++I L E + + L+ GG GLF+GASIL+ +EL +Y L+
Sbjct: 401 NILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKE 460
Query: 446 PFCDIYSQREDD 457
D+ + ED+
Sbjct: 461 KLLDLLGKEEDE 472
>BC010439-1|AAH10439.1| 647|Homo sapiens amiloride-sensitive cation
channel 4, pituitary protein.
Length = 647
Score = 47.2 bits (107), Expect = 1e-04
Identities = 40/149 (26%), Positives = 68/149 (45%), Gaps = 16/149 (10%)
Query: 295 LDVYRHYSYTACTVQCRKDAQMRFCNCSNYFMPNV----PEHLKCNVSGIICLNNYVNIL 350
L Y YS +AC ++C K+A ++ C+C MP+ PE C L Y +
Sbjct: 434 LQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPDSLGGGPEG-PCFCPTPCNLTRYGKEI 492
Query: 351 TVLKAPWSSRPGLYCNCLPSCTESEISVINDLKDATAEDYATVEIELAMLPSERYRRNVV 410
++++ P + Y + E+ I E++ +++ L SE +
Sbjct: 493 SMVRIP-NRGSARYLARKYNRNETYIR----------ENFLVLDVFFEALTSEAMEQRAA 541
Query: 411 RGILDLVVSTGGTGGLFLGASILSFVELL 439
G+ L+ GG GLF+GASIL+ +E+L
Sbjct: 542 YGLSALLGDLGGQMGLFIGASILTLLEIL 570
>BC073912-1|AAH73912.1| 296|Homo sapiens ACCN4 protein protein.
Length = 296
Score = 46.4 bits (105), Expect = 2e-04
Identities = 54/204 (26%), Positives = 86/204 (42%), Gaps = 31/204 (15%)
Query: 295 LDVYRHYSYTACTVQCRKDAQMRFCNCSNYFMPNVPEHLKCNVSGIICLNNYVNILTVLK 354
L Y YS +AC ++C K+A ++ C+C MP N+ I C ++ ++ L
Sbjct: 88 LQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIY-IECADHTLDSL---- 142
Query: 355 APWSSRPGLYCNCLPSCTES----EISVINDLKDATA---------------EDYATVEI 395
P C C C + EIS++ +A E++ +++
Sbjct: 143 ---GGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDV 199
Query: 396 ELAMLPSERYRRNVVRGILDLVVSTGGTGGLFLGASILSFVELL-YILLIRPFCDIYSQR 454
L SE + G+ L+ GG GLF+GASIL+ +E+L YI R +
Sbjct: 200 FFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEARAL--EKAGW 257
Query: 455 EDDPWYRKYGTRRLEDNKYTPNWK 478
E PW ++ G R + P WK
Sbjct: 258 EWGPWAKQKGAVRGAWWSW-PGWK 280
>U78181-1|AAB48981.1| 528|Homo sapiens sodium channel 2 protein.
Length = 528
Score = 45.6 bits (103), Expect = 4e-04
Identities = 74/297 (24%), Positives = 115/297 (38%), Gaps = 34/297 (11%)
Query: 167 KESLSDCSWNGEAFECCDYFRPLDTELGTCYAINSIQGRESNPPFLRMVSNRTTGPGV-L 225
++ L C + GE D F+ + T G CY NS GR+ P M TG G+ +
Sbjct: 166 RDMLLSCHFRGEVCSAED-FKVVFTRYGKCYTFNS--GRDGRPRLKTMKDG--TGNGLEI 220
Query: 226 RFNVLIPANVYVLNEEDVPALTT-----IGS-------DVLTVGPEMFHRRYIALRNIEN 273
++ + V E D + I S D L G + ++A +
Sbjct: 221 MLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQ---- 276
Query: 274 DSGTRSIAPEKRKCR-YNDENFLDVYRHYSYTACTVQCRKDAQMRFCNCSNYFMPN---- 328
+ + P C+ ++ LD + YS TAC + C + CNC MP
Sbjct: 277 EQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPY 336
Query: 329 -VPEHLK-CNVSGIICLNNYVNILTVLKAPWS-SRPG--LYCNCLPSCTESE--ISVIND 381
PE K C + L V + P + +R G L +PS ++ N
Sbjct: 337 CTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNK 396
Query: 382 LKDATAEDYATVEIELAMLPSERYRRNVVRGILDLVVSTGGTGGLFLGASILSFVEL 438
+ E+ ++I +L E + I L+ GG GLF+GASIL+ +EL
Sbjct: 397 SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLEL 453
>BC133707-1|AAI33708.1| 528|Homo sapiens amiloride-sensitive cation
channel 2, neuronal protein.
Length = 528
Score = 45.6 bits (103), Expect = 4e-04
Identities = 74/297 (24%), Positives = 115/297 (38%), Gaps = 34/297 (11%)
Query: 167 KESLSDCSWNGEAFECCDYFRPLDTELGTCYAINSIQGRESNPPFLRMVSNRTTGPGV-L 225
++ L C + GE D F+ + T G CY NS GR+ P M TG G+ +
Sbjct: 166 RDMLLSCHFRGEVCSAED-FKVVFTRYGKCYTFNS--GRDGRPRLKTMKGG--TGNGLEI 220
Query: 226 RFNVLIPANVYVLNEEDVPALTT-----IGS-------DVLTVGPEMFHRRYIALRNIEN 273
++ + V E D + I S D L G + ++A +
Sbjct: 221 MLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQ---- 276
Query: 274 DSGTRSIAPEKRKCR-YNDENFLDVYRHYSYTACTVQCRKDAQMRFCNCSNYFMPN---- 328
+ + P C+ ++ LD + YS TAC + C + CNC MP
Sbjct: 277 EQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPY 336
Query: 329 -VPEHLK-CNVSGIICLNNYVNILTVLKAPWS-SRPG--LYCNCLPSCTESE--ISVIND 381
PE K C + L V + P + +R G L +PS ++ N
Sbjct: 337 CTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNK 396
Query: 382 LKDATAEDYATVEIELAMLPSERYRRNVVRGILDLVVSTGGTGGLFLGASILSFVEL 438
+ E+ ++I +L E + I L+ GG GLF+GASIL+ +EL
Sbjct: 397 SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLEL 453
>AJ408881-1|CAC51338.1| 539|Homo sapiens acid sensing ion channel 4
protein.
Length = 539
Score = 45.2 bits (102), Expect = 6e-04
Identities = 43/164 (26%), Positives = 71/164 (43%), Gaps = 27/164 (16%)
Query: 295 LDVYRHYSYTACTVQCRKDAQMRFCNCSNYFMPNVPEHLKCNVSGIICLNNYVNILTVLK 354
L Y YS +AC ++C K+A ++ C+C MP N+ I C ++ ++ L
Sbjct: 307 LQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIY-IECADHTLDSL---- 361
Query: 355 APWSSRPGLYCNCLPSCTES----EISVINDLKDATA---------------EDYATVEI 395
P C C C + EIS++ +A E++ +++
Sbjct: 362 ---GGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDV 418
Query: 396 ELAMLPSERYRRNVVRGILDLVVSTGGTGGLFLGASILSFVELL 439
L SE + G+ L+ GG GLF+GASIL+ +E+L
Sbjct: 419 FFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEIL 462
>AJ271643-1|CAB93980.1| 539|Homo sapiens putative acid-sensing ion
channel protein.
Length = 539
Score = 45.2 bits (102), Expect = 6e-04
Identities = 43/164 (26%), Positives = 71/164 (43%), Gaps = 27/164 (16%)
Query: 295 LDVYRHYSYTACTVQCRKDAQMRFCNCSNYFMPNVPEHLKCNVSGIICLNNYVNILTVLK 354
L Y YS +AC ++C K+A ++ C+C MP N+ I C ++ ++ L
Sbjct: 307 LQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIY-IECADHTLDSL---- 361
Query: 355 APWSSRPGLYCNCLPSCTES----EISVINDLKDATA---------------EDYATVEI 395
P C C C + EIS++ +A E++ +++
Sbjct: 362 ---GGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDV 418
Query: 396 ELAMLPSERYRRNVVRGILDLVVSTGGTGGLFLGASILSFVELL 439
L SE + G+ L+ GG GLF+GASIL+ +E+L
Sbjct: 419 FFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEIL 462
>AJ252011-1|CAB85607.1| 505|Homo sapiens amiloride-sensitive sodium
channel protein.
Length = 505
Score = 38.3 bits (85), Expect = 0.063
Identities = 97/456 (21%), Positives = 178/456 (39%), Gaps = 69/456 (15%)
Query: 24 TTSIHGFKFIADTKRHWVERIFWLVFVALSWYASSLLIAAQYDAYLNNPISFVVETTYKD 83
+TS HG I R + R+ WLV V S + I + Y P + +E Y +
Sbjct: 44 STSFHGIHNIVQN-RSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVE 102
Query: 84 WNTYFPAVAVCENDNSKRAEEISDS-----LWG-QEHDFNIEEVLKEWAFFKGVTYYTSE 137
FPAV C N N + + ++ LW +++E+ + T + +
Sbjct: 103 -KMEFPAVTFC-NLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAAS 160
Query: 138 FCNVENGEVLPECVESNLTYYANLVRSTCKESLSDCSWNGEAFECCDYFRPLDTELGTCY 197
N E + N +Y N +L DC + G+ D F + TE G C+
Sbjct: 161 HQNFSIVEFI-----RNKGFYLN------NSTLLDCEFFGKPCSPKD-FAHVFTEYGNCF 208
Query: 198 AINSIQGRESNPPFLRMVSNRTTGPGVLRFNV------------LIPANV-YVLNE-EDV 243
N + ++ R VS G +L FNV + A + +V++ + V
Sbjct: 209 TFNHGETLQAK----RKVSVSGRGLSLL-FNVNQEAFTDNPALGFVDAGIIFVIHSPKKV 263
Query: 244 PALTTIGSDVLTVGPEMFHRRYIALRNIENDSGTRSIAPEKRKCRYNDENFLDVYRHYSY 303
P +G + P H R + +R + +++ E N L + YS
Sbjct: 264 PQFDGLG----LLSPVGMHAR-VTIRQV------KTVHQEYPWGECNPNIKLQNFSSYST 312
Query: 304 TACTVQCRKDAQMRFCNCSNYFMP------NVPEHLKCNVSGIICLNNYVNILTV----L 353
+ C +C+ + C C + +P ++ ++ C VS ++ + ++ TV
Sbjct: 313 SGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSC-VSPVLDHIEFKDLCTVGTHNS 371
Query: 354 KAPWSSRPGLYCNCLP-SCTESEISV------INDLKDATAEDYATVEIELAMLPSERYR 406
P S Y + S S+ ++ +N + E+ +EI + L + +
Sbjct: 372 SCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQ 431
Query: 407 RNVVRGILDLVVSTGGTGGLFLGASILSFVELLYIL 442
+ + +L+ GG GLF GAS+++ +E++ L
Sbjct: 432 QQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYL 467
>X87159-1|CAA60632.1| 640|Homo sapiens epithelial
amiloride-sensitive sodium channel, beta-subunit
protein.
Length = 640
Score = 35.9 bits (79), Expect = 0.34
Identities = 24/98 (24%), Positives = 40/98 (40%), Gaps = 4/98 (4%)
Query: 292 ENFLDVYRH-YSYTACTVQCRKDAQMRFCNCSNYFMPNVPEHLKCNVSGIICLNNYVNIL 350
+NF Y YS AC C +D +R CNC +Y P CN ++ +
Sbjct: 371 QNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRD---FPDWAHCY 427
Query: 351 TVLKAPWSSRPGLYCNCLPSCTESEISVINDLKDATAE 388
+ L+ + R C SC +++ + + D +E
Sbjct: 428 SDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSE 465
>L36593-1|AAA75459.1| 640|Homo sapiens epithelial sodium channel
beta subunit protein.
Length = 640
Score = 35.9 bits (79), Expect = 0.34
Identities = 24/98 (24%), Positives = 40/98 (40%), Gaps = 4/98 (4%)
Query: 292 ENFLDVYRH-YSYTACTVQCRKDAQMRFCNCSNYFMPNVPEHLKCNVSGIICLNNYVNIL 350
+NF Y YS AC C +D +R CNC +Y P CN ++ +
Sbjct: 371 QNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRD---FPDWAHCY 427
Query: 351 TVLKAPWSSRPGLYCNCLPSCTESEISVINDLKDATAE 388
+ L+ + R C SC +++ + + D +E
Sbjct: 428 SDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSE 465
>BC036352-1|AAH36352.2| 640|Homo sapiens sodium channel,
nonvoltage-gated 1, beta (Liddle syndrome) protein.
Length = 640
Score = 35.9 bits (79), Expect = 0.34
Identities = 24/98 (24%), Positives = 40/98 (40%), Gaps = 4/98 (4%)
Query: 292 ENFLDVYRH-YSYTACTVQCRKDAQMRFCNCSNYFMPNVPEHLKCNVSGIICLNNYVNIL 350
+NF Y YS AC C +D +R CNC +Y P CN ++ +
Sbjct: 371 QNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRD---FPDWAHCY 427
Query: 351 TVLKAPWSSRPGLYCNCLPSCTESEISVINDLKDATAE 388
+ L+ + R C SC +++ + + D +E
Sbjct: 428 SDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSE 465
>AJ005383-1|CAA06508.2| 640|Homo sapiens ENaCB, amiloride sensitive
sodium channel beta subunit protein.
Length = 640
Score = 35.9 bits (79), Expect = 0.34
Identities = 24/98 (24%), Positives = 40/98 (40%), Gaps = 4/98 (4%)
Query: 292 ENFLDVYRH-YSYTACTVQCRKDAQMRFCNCSNYFMPNVPEHLKCNVSGIICLNNYVNIL 350
+NF Y YS AC C +D +R CNC +Y P CN ++ +
Sbjct: 371 QNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRD---FPDWAHCY 427
Query: 351 TVLKAPWSSRPGLYCNCLPSCTESEISVINDLKDATAE 388
+ L+ + R C SC +++ + + D +E
Sbjct: 428 SDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSE 465
>BC036538-1|AAH36538.1| 425|Homo sapiens synaptotagmin IV protein.
Length = 425
Score = 33.9 bits (74), Expect = 1.4
Identities = 32/96 (33%), Positives = 44/96 (45%), Gaps = 8/96 (8%)
Query: 332 HL-KCNVSGIICLNNYVNI-LTVLKAPWSSRPGLYCNCLPSCTESEISVINDLKDATAED 389
HL K +VSG+ + YV + L K S + C P+ +E+ V D E
Sbjct: 313 HLPKSDVSGLS--DPYVKVNLYHAKKRISKKKTHVKKCTPNAVFNELFVF----DIPCEG 366
Query: 390 YATVEIELAMLPSERYRRNVVRGILDLVVSTGGTGG 425
+ +E +L SER RN V G L L + GTGG
Sbjct: 367 LEDISVEFLVLDSERGSRNEVIGQLVLGAAAEGTGG 402
>AF299075-1|AAG37229.1| 425|Homo sapiens synaptotagmin IV protein.
Length = 425
Score = 33.9 bits (74), Expect = 1.4
Identities = 32/96 (33%), Positives = 44/96 (45%), Gaps = 8/96 (8%)
Query: 332 HL-KCNVSGIICLNNYVNI-LTVLKAPWSSRPGLYCNCLPSCTESEISVINDLKDATAED 389
HL K +VSG+ + YV + L K S + C P+ +E+ V D E
Sbjct: 313 HLPKSDVSGLS--DPYVKVNLYHAKKRISKKKTHVKKCTPNAVFNELFVF----DIPCEG 366
Query: 390 YATVEIELAMLPSERYRRNVVRGILDLVVSTGGTGG 425
+ +E +L SER RN V G L L + GTGG
Sbjct: 367 LEDISVEFLVLDSERGSRNEVIGQLVLGAAAEGTGG 402
>AB037763-1|BAA92580.1| 426|Homo sapiens KIAA1342 protein protein.
Length = 426
Score = 33.9 bits (74), Expect = 1.4
Identities = 32/96 (33%), Positives = 44/96 (45%), Gaps = 8/96 (8%)
Query: 332 HL-KCNVSGIICLNNYVNI-LTVLKAPWSSRPGLYCNCLPSCTESEISVINDLKDATAED 389
HL K +VSG+ + YV + L K S + C P+ +E+ V D E
Sbjct: 314 HLPKSDVSGLS--DPYVKVNLYHAKKRISKKKTHVKKCTPNAVFNELFVF----DIPCEG 367
Query: 390 YATVEIELAMLPSERYRRNVVRGILDLVVSTGGTGG 425
+ +E +L SER RN V G L L + GTGG
Sbjct: 368 LEDISVEFLVLDSERGSRNEVIGQLVLGAAAEGTGG 403
>U78180-1|AAB48980.1| 574|Homo sapiens sodium channel 2 protein.
Length = 574
Score = 33.5 bits (73), Expect = 1.8
Identities = 43/175 (24%), Positives = 67/175 (38%), Gaps = 23/175 (13%)
Query: 167 KESLSDCSWNGEAFECCDYFRPLDTELGTCYAINSIQGRESNPPFLRMVSNRTTGPGV-L 225
++ L C + GE D F+ + T G CY NS GR+ P M TG G+ +
Sbjct: 166 RDMLLSCHFRGEVCSAED-FKVVFTRYGKCYTFNS--GRDGRPRLKTMKDG--TGNGLEI 220
Query: 226 RFNVLIPANVYVLNEEDVPALTT-----IGS-------DVLTVGPEMFHRRYIALRNIEN 273
++ + V E D + I S D L G + ++A +
Sbjct: 221 MLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQ---- 276
Query: 274 DSGTRSIAPEKRKCR-YNDENFLDVYRHYSYTACTVQCRKDAQMRFCNCSNYFMP 327
+ + P C+ ++ LD + YS TAC + C + CNC MP
Sbjct: 277 EQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMP 331
>AF195025-1|AAF19818.1| 549|Homo sapiens acid sensing ion channel 3
splice variant c protein.
Length = 549
Score = 32.7 bits (71), Expect = 3.2
Identities = 23/86 (26%), Positives = 41/86 (47%), Gaps = 6/86 (6%)
Query: 387 AEDYATVEIELAMLPSERYRRNVVRGILDLVVSTGGTGGLFLGASILSFVELLYILLIRP 446
AE+ ++I L E + + +L+ GG GLF+GAS+L+ +E+L L
Sbjct: 405 AENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYL---- 460
Query: 447 FCDIYSQRE-DDPWYRKYGTRRLEDN 471
C+++ + W R++ R N
Sbjct: 461 -CEVFRDKVLGYFWNRQHSQRHSSTN 485
>AF195024-1|AAF19817.1| 543|Homo sapiens acid sensing ion channel 3
splice variant b protein.
Length = 543
Score = 32.7 bits (71), Expect = 3.2
Identities = 23/86 (26%), Positives = 41/86 (47%), Gaps = 6/86 (6%)
Query: 387 AEDYATVEIELAMLPSERYRRNVVRGILDLVVSTGGTGGLFLGASILSFVELLYILLIRP 446
AE+ ++I L E + + +L+ GG GLF+GAS+L+ +E+L L
Sbjct: 405 AENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYL---- 460
Query: 447 FCDIYSQRE-DDPWYRKYGTRRLEDN 471
C+++ + W R++ R N
Sbjct: 461 -CEVFRDKVLGYFWNRQHSQRHSSTN 485
>AF095897-1|AAC64188.1| 531|Homo sapiens proton-gated cation
channel ASIC3 protein.
Length = 531
Score = 32.7 bits (71), Expect = 3.2
Identities = 23/86 (26%), Positives = 41/86 (47%), Gaps = 6/86 (6%)
Query: 387 AEDYATVEIELAMLPSERYRRNVVRGILDLVVSTGGTGGLFLGASILSFVELLYILLIRP 446
AE+ ++I L E + + +L+ GG GLF+GAS+L+ +E+L L
Sbjct: 405 AENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYL---- 460
Query: 447 FCDIYSQRE-DDPWYRKYGTRRLEDN 471
C+++ + W R++ R N
Sbjct: 461 -CEVFRDKVLGYFWNRQHSQRHSSTN 485
>AF057711-1|AAC62935.1| 531|Homo sapiens proton-gated cation
channel subunit protein.
Length = 531
Score = 32.7 bits (71), Expect = 3.2
Identities = 23/86 (26%), Positives = 41/86 (47%), Gaps = 6/86 (6%)
Query: 387 AEDYATVEIELAMLPSERYRRNVVRGILDLVVSTGGTGGLFLGASILSFVELLYILLIRP 446
AE+ ++I L E + + +L+ GG GLF+GAS+L+ +E+L L
Sbjct: 405 AENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYL---- 460
Query: 447 FCDIYSQRE-DDPWYRKYGTRRLEDN 471
C+++ + W R++ R N
Sbjct: 461 -CEVFRDKVLGYFWNRQHSQRHSSTN 485
>AB010575-1|BAA25897.1| 532|Homo sapiens sodium channel protein.
Length = 532
Score = 32.7 bits (71), Expect = 3.2
Identities = 23/86 (26%), Positives = 41/86 (47%), Gaps = 6/86 (6%)
Query: 387 AEDYATVEIELAMLPSERYRRNVVRGILDLVVSTGGTGGLFLGASILSFVELLYILLIRP 446
AE+ ++I L E + + +L+ GG GLF+GAS+L+ +E+L L
Sbjct: 406 AENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYL---- 461
Query: 447 FCDIYSQRE-DDPWYRKYGTRRLEDN 471
C+++ + W R++ R N
Sbjct: 462 -CEVFRDKVLGYFWNRQHSQRHSSTN 486
>BC013891-1|AAH13891.2| 344|Homo sapiens ACCN2 protein protein.
Length = 344
Score = 32.3 bits (70), Expect = 4.2
Identities = 13/33 (39%), Positives = 16/33 (48%)
Query: 295 LDVYRHYSYTACTVQCRKDAQMRFCNCSNYFMP 327
LD + YS TAC + C + CNC MP
Sbjct: 69 LDFFDSYSITACRIDCETRYLVENCNCRMVHMP 101
>BC001107-1|AAH01107.1| 183|Homo sapiens FUS interacting protein
(serine/arginine-rich) 1 protein.
Length = 183
Score = 31.5 bits (68), Expect = 7.3
Identities = 17/43 (39%), Positives = 21/43 (48%), Gaps = 1/43 (2%)
Query: 451 YSQREDDPWYRKYGTRRLEDNKYTPNWKWNYFRSKSYYTTRPL 493
YS R P R +R DN PN WN S +YYT+R +
Sbjct: 142 YSPRNSRPTGRPRRSRSHSDND-RPNCSWNTQYSSAYYTSRKI 183
>AY150181-1|AAN65381.1| 183|Homo sapiens splicing factor SRp38-2
protein.
Length = 183
Score = 31.5 bits (68), Expect = 7.3
Identities = 17/43 (39%), Positives = 21/43 (48%), Gaps = 1/43 (2%)
Query: 451 YSQREDDPWYRKYGTRRLEDNKYTPNWKWNYFRSKSYYTTRPL 493
YS R P R +R DN PN WN S +YYT+R +
Sbjct: 142 YSPRNSRPTGRPRRSRSHSDND-RPNCSWNTQYSSAYYTSRKI 183
>AY048592-1|AAL06098.1| 183|Homo sapiens TLS-associated SR protein
1 protein.
Length = 183
Score = 31.5 bits (68), Expect = 7.3
Identities = 17/43 (39%), Positives = 21/43 (48%), Gaps = 1/43 (2%)
Query: 451 YSQREDDPWYRKYGTRRLEDNKYTPNWKWNYFRSKSYYTTRPL 493
YS R P R +R DN PN WN S +YYT+R +
Sbjct: 142 YSPRNSRPTGRPRRSRSHSDND-RPNCSWNTQYSSAYYTSRKI 183
>AL590609-5|CAI14803.1| 183|Homo sapiens FUS interacting protein
(serine/arginine-rich) 1 protein.
Length = 183
Score = 31.5 bits (68), Expect = 7.3
Identities = 17/43 (39%), Positives = 21/43 (48%), Gaps = 1/43 (2%)
Query: 451 YSQREDDPWYRKYGTRRLEDNKYTPNWKWNYFRSKSYYTTRPL 493
YS R P R +R DN PN WN S +YYT+R +
Sbjct: 142 YSPRNSRPTGRPRRSRSHSDND-RPNCSWNTQYSSAYYTSRKI 183
>AK001286-1|BAA91601.1| 183|Homo sapiens protein ( Homo sapiens
cDNA FLJ10424 fis, clone NT2RP1000272, highly similar to
Homo sapiens TLS-associated protein TASR-2 mRNA. ).
Length = 183
Score = 31.5 bits (68), Expect = 7.3
Identities = 17/43 (39%), Positives = 21/43 (48%), Gaps = 1/43 (2%)
Query: 451 YSQREDDPWYRKYGTRRLEDNKYTPNWKWNYFRSKSYYTTRPL 493
YS R P R +R DN PN WN S +YYT+R +
Sbjct: 142 YSPRNSRPTGRPRRSRSHSDND-RPNCSWNTQYSSAYYTSRKI 183
>AF419331-1|AAL16665.1| 183|Homo sapiens TLS-associated protein
TASR-1 protein.
Length = 183
Score = 31.5 bits (68), Expect = 7.3
Identities = 17/43 (39%), Positives = 21/43 (48%), Gaps = 1/43 (2%)
Query: 451 YSQREDDPWYRKYGTRRLEDNKYTPNWKWNYFRSKSYYTTRPL 493
YS R P R +R DN PN WN S +YYT+R +
Sbjct: 142 YSPRNSRPTGRPRRSRSHSDND-RPNCSWNTQYSSAYYTSRKI 183
>AF047448-1|AAC70918.1| 183|Homo sapiens TLS-associated protein
TASR protein.
Length = 183
Score = 31.5 bits (68), Expect = 7.3
Identities = 17/43 (39%), Positives = 21/43 (48%), Gaps = 1/43 (2%)
Query: 451 YSQREDDPWYRKYGTRRLEDNKYTPNWKWNYFRSKSYYTTRPL 493
YS R P R +R DN PN WN S +YYT+R +
Sbjct: 142 YSPRNSRPTGRPRRSRSHSDND-RPNCSWNTQYSSAYYTSRKI 183
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.321 0.136 0.436
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 81,040,764
Number of Sequences: 224733
Number of extensions: 3584490
Number of successful extensions: 5532
Number of sequences better than 10.0: 33
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 5483
Number of HSP's gapped (non-prelim): 54
length of query: 509
length of database: 73,234,838
effective HSP length: 93
effective length of query: 416
effective length of database: 52,334,669
effective search space: 21771222304
effective search space used: 21771222304
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 67 (31.1 bits)
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