Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA005333-TA|BGIBMGA005333-PA|IPR001849|Pleckstrin-like,
IPR000719|Protein kinase, IPR008271|Serine/threonine protein kinase,
active site, IPR000239|GPCR kinase, IPR002290|Serine/threonine protein
kinase, IPR000961|Protein kinase, C-terminal, IPR011009|Protein
kinase-like
(568 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
M80776-1|AAA58391.1| 689|Homo sapiens receptor kinase protein. 762 0.0
BC090863-1|AAH90863.1| 689|Homo sapiens ADRBK1 protein protein. 762 0.0
BC037963-1|AAH37963.1| 689|Homo sapiens adrenergic, beta, recep... 762 0.0
X61157-1|CAA43470.1| 689|Homo sapiens beta-adrenergic receptor ... 758 0.0
AL022329-1|CAB45657.1| 688|Homo sapiens adrenergic, beta, recep... 752 0.0
X69117-1|CAA48870.1| 688|Homo sapiens beta-adrenergic kinase 2 ... 750 0.0
U08438-1|AAB60689.1| 689|Homo sapiens beta-adrenergic receptor ... 723 0.0
BC036797-1|AAH36797.1| 387|Homo sapiens ADRBK2 protein protein. 449 e-125
AB209588-1|BAD92825.1| 360|Homo sapiens beta adrenergic recepto... 389 e-107
U00686-1|AAA03565.1| 544|Homo sapiens putative novel receptor k... 284 5e-76
L16862-1|AAA60175.1| 576|Homo sapiens G protein-coupled recepto... 284 5e-76
BC009277-1|AAH09277.1| 576|Homo sapiens G protein-coupled recep... 284 5e-76
AF040752-1|AAC09274.1| 560|Homo sapiens G protein-coupled recep... 284 5e-76
AF040751-1|AAC09273.1| 589|Homo sapiens G protein-coupled recep... 284 5e-76
BC017272-1|AAH17272.1| 589|Homo sapiens G protein-coupled recep... 283 9e-76
L15388-1|AAA58620.1| 590|Homo sapiens G protein-coupled recepto... 277 8e-74
BC064506-1|AAH64506.1| 590|Homo sapiens G protein-coupled recep... 277 8e-74
AL583824-2|CAI16759.1| 590|Homo sapiens G protein-coupled recep... 277 8e-74
AL355861-4|CAI15804.1| 590|Homo sapiens G protein-coupled recep... 277 8e-74
AL355273-2|CAI16487.1| 590|Homo sapiens G protein-coupled recep... 277 8e-74
AK131506-1|BAD18650.1| 251|Homo sapiens protein ( Homo sapiens ... 275 2e-73
U33168-3|AAC50409.1| 546|Homo sapiens G protein-coupled recepto... 273 9e-73
U33168-1|AAC50410.1| 578|Homo sapiens G protein-coupled recepto... 273 9e-73
X97881-1|CAA66470.1| 578|Homo sapiens G-protein coupled recepto... 273 1e-72
X97880-1|CAA66469.1| 546|Homo sapiens G-protein coupled recepto... 273 1e-72
U33055-1|AAC50407.1| 546|Homo sapiens G protein-coupled recepto... 273 1e-72
U33054-1|AAC50406.1| 578|Homo sapiens G protein-coupled recepto... 273 1e-72
BC117320-1|AAI17321.1| 578|Homo sapiens G protein-coupled recep... 273 1e-72
U33168-4|AAC50412.1| 500|Homo sapiens G protein-coupled recepto... 270 7e-72
U33168-2|AAC50411.1| 532|Homo sapiens G protein-coupled recepto... 270 7e-72
X98118-1|CAA66802.1| 532|Homo sapiens G protein-coupled recepto... 270 9e-72
X97879-1|CAA66468.1| 500|Homo sapiens G-protein coupled recepto... 270 9e-72
U33056-1|AAC50408.1| 532|Homo sapiens G protein-coupled recepto... 270 9e-72
L03718-1|AAB04045.1| 500|Homo sapiens G protein-coupled recepto... 270 9e-72
AK223581-1|BAD97301.1| 500|Homo sapiens G protein-coupled recep... 270 1e-71
AF439409-1|AAL48216.1| 553|Homo sapiens G-protein-coupled recep... 242 2e-63
AF282269-1|AAL33880.1| 553|Homo sapiens G protein-coupled recep... 242 2e-63
U63973-1|AAB05929.1| 563|Homo sapiens rhodopsin kinase protein. 241 6e-63
L77503-1|AAG50439.1| 563|Homo sapiens rhodopsin kinase protein. 241 6e-63
L77502-1|AAT00534.2| 563|Homo sapiens rhodopsin kinase protein. 241 6e-63
L07597-1|AAC82497.1| 735|Homo sapiens ribosomal protein S6 kina... 215 3e-55
BC014966-1|AAH14966.1| 735|Homo sapiens ribosomal protein S6 ki... 213 2e-54
AL627313-6|CAI14649.1| 735|Homo sapiens ribosomal protein S6 ki... 213 2e-54
U08316-1|AAA81952.1| 740|Homo sapiens insulin-stimulated protei... 212 2e-54
L07599-1|AAC82495.1| 580|Homo sapiens ribosomal protein S6 kina... 212 2e-54
BC096303-1|AAH96303.1| 740|Homo sapiens ribosomal protein S6 ki... 212 2e-54
BC096302-1|AAH96302.1| 740|Homo sapiens ribosomal protein S6 ki... 212 2e-54
BC096301-1|AAH96301.1| 740|Homo sapiens ribosomal protein S6 ki... 212 2e-54
AL807772-3|CAI39687.1| 740|Homo sapiens ribosomal protein S6 ki... 212 2e-54
AL732366-2|CAI40548.1| 740|Homo sapiens ribosomal protein S6 ki... 212 2e-54
AB208933-1|BAD92170.1| 806|Homo sapiens ribosomal protein S6 ki... 212 2e-54
AB102662-1|BAC81131.1| 726|Homo sapiens RPS6KA3 protein. 212 2e-54
AL389887-1|CAC16111.2| 745|Homo sapiens ribosomal protein S6 ki... 211 6e-54
AL354653-1|CAD13486.2| 745|Homo sapiens ribosomal protein S6 ki... 211 6e-54
AF184965-1|AAF13190.1| 745|Homo sapiens ribosomal S6 kinase pro... 211 6e-54
CR536566-1|CAG38803.1| 745|Homo sapiens RPS6KA6 protein. 210 1e-53
BC017187-1|AAH17187.1| 549|Homo sapiens ribosomal protein S6 ki... 208 3e-53
AF090421-1|AAC69577.1| 809|Homo sapiens ribosome S6 protein kin... 208 3e-53
AF080000-1|AAD23915.1| 802|Homo sapiens RSK-like protein kinase... 208 3e-53
AF074393-1|AAC31171.1| 802|Homo sapiens nuclear mitogen- and st... 208 3e-53
BC047896-1|AAH47896.1| 524|Homo sapiens RPS6KA4 protein protein. 204 7e-52
BC028079-1|AAH28079.1| 556|Homo sapiens Unknown (protein for IM... 204 7e-52
AK223561-1|BAD97281.1| 765|Homo sapiens ribosomal protein S6 ki... 204 7e-52
AJ010119-1|CAA09009.1| 772|Homo sapiens Ribosomal protein kinas... 204 7e-52
AF074715-1|AAC67395.1| 705|Homo sapiens mitogen- and stress-act... 204 7e-52
X85106-1|CAA59427.1| 733|Homo sapiens ribosomal S6 kinase protein. 203 1e-51
L07598-1|AAC82496.1| 540|Homo sapiens ribosomal protein S6 kina... 203 1e-51
Z98049-1|CAI20579.1| 733|Homo sapiens ribosomal protein S6 kina... 203 2e-51
BC002363-1|AAH02363.1| 733|Homo sapiens ribosomal protein S6 ki... 203 2e-51
AL022069-2|CAI19651.1| 733|Homo sapiens ribosomal protein S6 ki... 203 2e-51
AB209116-1|BAD92353.1| 806|Homo sapiens ribosomal protein S6 ki... 203 2e-51
M63167-1|AAA36539.1| 480|Homo sapiens rac protein kinase-alpha ... 200 8e-51
BC084538-1|AAH84538.1| 480|Homo sapiens v-akt murine thymoma vi... 200 8e-51
BC000479-1|AAH00479.1| 480|Homo sapiens v-akt murine thymoma vi... 200 8e-51
AF283830-1|AAL55732.1| 480|Homo sapiens AKT1 protein. 200 8e-51
M95936-1|AAA58364.1| 481|Homo sapiens protein serine/threonine ... 200 1e-50
M77198-1|AAA36585.1| 520|Homo sapiens rac protein kinase-beta p... 200 1e-50
BC120994-1|AAI20995.1| 481|Homo sapiens v-akt murine thymoma vi... 200 1e-50
X61037-1|CAA43372.1| 417|Homo sapiens human protein kinase B p... 189 3e-47
X06318-1|CAA29634.1| 671|Homo sapiens protein ( Human mRNA for ... 188 3e-47
AC002299-1|AAB97933.1| 494|Homo sapiens Protein kinase C beta (... 188 3e-47
AY633609-1|AAV33302.1| 672|Homo sapiens aging-associated gene 6... 186 2e-46
X52479-1|CAA36718.1| 672|Homo sapiens protein ( Human PKC alpha... 185 4e-46
BC109274-1|AAI09275.1| 672|Homo sapiens protein kinase C, alpha... 185 4e-46
BC109273-1|AAI09274.1| 672|Homo sapiens protein kinase C, alpha... 185 4e-46
Z84486-1|CAI21678.1| 526|Homo sapiens serum/glucocorticoid regu... 181 5e-45
BC001263-1|AAH01263.1| 431|Homo sapiens serum/glucocorticoid re... 181 5e-45
AL355881-2|CAH72579.1| 526|Homo sapiens serum/glucocorticoid re... 181 5e-45
AL135839-4|CAI19721.1| 526|Homo sapiens serum/glucocorticoid re... 181 5e-45
AL135839-3|CAI19720.1| 445|Homo sapiens serum/glucocorticoid re... 181 5e-45
AL135839-2|CAI19719.1| 431|Homo sapiens serum/glucocorticoid re... 181 5e-45
AL135839-1|CAI19718.1| 421|Homo sapiens serum/glucocorticoid re... 181 5e-45
AF153609-1|AAD41091.1| 431|Homo sapiens serine/threonine protei... 181 5e-45
Y10032-1|CAA71138.1| 431|Homo sapiens serine/threonine protein ... 180 9e-45
AJ000512-1|CAA04146.1| 431|Homo sapiens serine/threonine protei... 180 9e-45
X07109-1|CAA30130.1| 673|Homo sapiens protein ( Human mRNA for ... 178 5e-44
M13975-1|AAA60095.1| 673|Homo sapiens protein kinase C beta-II ... 178 5e-44
BC036472-1|AAH36472.1| 673|Homo sapiens protein kinase C, beta ... 178 5e-44
AC002299-2|AAB97934.1| 496|Homo sapiens Protein kinase C beta (... 178 5e-44
M60725-1|AAA36411.1| 502|Homo sapiens p70 ribosomal S6 kinase a... 177 9e-44
M60724-1|AAA36410.1| 525|Homo sapiens p70 ribosomal S6 kinase a... 177 9e-44
BC053365-1|AAH53365.1| 451|Homo sapiens RPS6KB1 protein protein. 177 9e-44
L33881-1|AAB17011.1| 587|Homo sapiens protein kinase C iota pro... 175 5e-43
L18964-1|AAA60171.1| 587|Homo sapiens protein kinase C iota pro... 175 5e-43
BC022016-1|AAH22016.3| 587|Homo sapiens protein kinase C, iota ... 174 6e-43
AJ250839-1|CAB76471.1| 414|Homo sapiens serine/threonine protei... 171 4e-42
AB019245-1|BAA37145.1| 481|Homo sapiens S6 kinase b protein. 170 1e-41
BC040061-1|AAH40061.1| 942|Homo sapiens protein kinase N1 protein. 170 1e-41
BC038238-1|AAH38238.1| 414|Homo sapiens serine/threonine kinase... 170 1e-41
BC006106-1|AAH06106.3| 482|Homo sapiens ribosomal protein S6 ki... 170 1e-41
U33053-1|AAC50209.1| 942|Homo sapiens PRK1 protein. 169 2e-41
S75546-1|AAB33345.1| 942|Homo sapiens protein kinase PRK1 protein. 169 2e-41
D26181-1|BAA05169.1| 942|Homo sapiens PKN protein. 169 2e-41
BC000094-1|AAH00094.3| 482|Homo sapiens ribosomal protein S6 ki... 169 2e-41
AF099739-1|AAD20990.1| 482|Homo sapiens S6 kinase-related kinas... 169 2e-41
AF076931-1|AAD46063.1| 482|Homo sapiens serine/threonine kinase... 169 2e-41
AB016869-1|BAA34402.1| 495|Homo sapiens p70 ribosomal S6 kinase... 169 2e-41
L07032-1|AAA60101.1| 706|Homo sapiens protein kinase C-theta pr... 169 2e-41
L01087-1|AAA75571.1| 706|Homo sapiens protein kinase C-theta pr... 169 2e-41
BT020098-1|AAV38901.1| 367|Homo sapiens serum/glucocorticoid re... 169 2e-41
BC113359-1|AAI13360.1| 706|Homo sapiens protein kinase C, theta... 169 2e-41
BC101465-1|AAI01466.1| 706|Homo sapiens protein kinase C, theta... 169 2e-41
AL158043-2|CAC12904.2| 706|Homo sapiens protein kinase C, theta... 169 2e-41
AL158043-1|CAI16127.1| 478|Homo sapiens protein kinase C, theta... 169 2e-41
AL137145-2|CAC10200.2| 706|Homo sapiens protein kinase C, theta... 169 2e-41
AL137145-1|CAI15756.1| 478|Homo sapiens protein kinase C, theta... 169 2e-41
U33052-1|AAC50208.1| 984|Homo sapiens PRK2 protein. 169 3e-41
S75548-1|AAB33346.1| 984|Homo sapiens protein kinase PRK2 protein. 169 3e-41
AL136381-3|CAI23271.1| 984|Homo sapiens protein kinase N2 protein. 169 3e-41
M55284-1|AAA60100.1| 682|Homo sapiens protein kinase C-L protein. 168 4e-41
BC125199-1|AAI25200.1| 936|Homo sapiens PKN2 protein protein. 168 5e-41
Z98752-7|CAC18509.1| 367|Homo sapiens serum/glucocorticoid regu... 167 7e-41
Z98752-5|CAI42312.1| 427|Homo sapiens serum/glucocorticoid regu... 167 7e-41
Z15114-1|CAA78820.1| 536|Homo sapiens protein kinase C gamma pr... 167 7e-41
BC065511-1|AAH65511.1| 367|Homo sapiens SGK2 protein protein. 167 7e-41
BC047876-1|AAH47876.1| 697|Homo sapiens protein kinase C, gamma... 167 7e-41
BC037268-1|AAH37268.1| 683|Homo sapiens protein kinase C, eta p... 167 7e-41
BC014037-1|AAH14037.3| 367|Homo sapiens serum/glucocorticoid re... 167 7e-41
AF345987-1|AAK13533.1| 697|Homo sapiens protein kinase C gamma ... 167 7e-41
AF186470-1|AAG17012.1| 427|Homo sapiens protein kinase protein. 167 7e-41
AF169034-1|AAF12757.2| 367|Homo sapiens protein kinase protein. 167 7e-41
X80229-1|CAA56515.1| 479|Homo sapiens serine/threonine protein ... 167 9e-41
Z98752-8|CAI42315.1| 366|Homo sapiens serum/glucocorticoid regu... 166 2e-40
AY987010-1|AAX88805.1| 393|Homo sapiens serum/glucocorticoid re... 166 2e-40
Z15108-1|CAA78813.1| 584|Homo sapiens protein kinase C zeta pro... 165 5e-40
BT007082-1|AAP35745.1| 592|Homo sapiens protein kinase C, zeta ... 165 5e-40
BC014270-1|AAH14270.1| 592|Homo sapiens protein kinase C, zeta ... 165 5e-40
BC008058-1|AAH08058.1| 592|Homo sapiens protein kinase C, zeta ... 165 5e-40
AL645703-1|CAI21535.1| 592|Homo sapiens protein kinase C, zeta ... 165 5e-40
AL590822-6|CAI12484.1| 592|Homo sapiens protein kinase C, zeta ... 165 5e-40
AL391845-5|CAI15438.1| 592|Homo sapiens protein kinase C, zeta ... 165 5e-40
L14283-1|AAA36488.1| 592|Homo sapiens protein kinase C zeta pro... 164 9e-40
BC020479-1|AAH20479.1| 466|Homo sapiens AKT3 protein protein. 163 1e-39
AY005799-1|AAF91073.1| 465|Homo sapiens protein kinase B gamma ... 163 1e-39
AL662889-3|CAH73073.1| 479|Homo sapiens v-akt murine thymoma vi... 163 1e-39
AL662889-2|CAH73072.1| 465|Homo sapiens v-akt murine thymoma vi... 163 1e-39
AL592151-2|CAH72892.1| 479|Homo sapiens v-akt murine thymoma vi... 163 1e-39
AL592151-1|CAH72891.1| 465|Homo sapiens v-akt murine thymoma vi... 163 1e-39
AL591721-2|CAH71867.1| 479|Homo sapiens v-akt murine thymoma vi... 163 1e-39
AL591721-1|CAH71866.1| 465|Homo sapiens v-akt murine thymoma vi... 163 1e-39
AJ245709-1|CAB53537.1| 479|Homo sapiens Akt-3 protein protein. 163 1e-39
AF135794-1|AAD24196.1| 479|Homo sapiens AKT3 protein kinase pro... 163 1e-39
AF124141-1|AAD29089.1| 479|Homo sapiens protein kinase B gamma ... 163 1e-39
AF085234-1|AAL40392.1| 479|Homo sapiens STK-2 protein. 163 1e-39
L07861-1|AAA03175.1| 676|Homo sapiens protein kinase C-delta 13... 163 1e-39
D10495-1|BAA01381.1| 626|Homo sapiens protein kinase C delta-ty... 163 1e-39
BC043350-1|AAH43350.1| 676|Homo sapiens protein kinase C, delta... 163 1e-39
L07860-1|AAA03176.1| 676|Homo sapiens protein kinase C-delta 13... 161 6e-39
BC121154-1|AAI21155.1| 465|Homo sapiens v-akt murine thymoma vi... 161 6e-39
BC032709-1|AAH32709.1| 344|Homo sapiens Unknown (protein for IM... 160 1e-38
AL807772-1|CAI39684.1| 227|Homo sapiens ribosomal protein S6 ki... 160 1e-38
CR536581-1|CAG38818.1| 429|Homo sapiens SGKL protein. 157 7e-38
BC015326-1|AAH15326.1| 496|Homo sapiens serum/glucocorticoid re... 157 7e-38
AK223523-1|BAD97243.1| 496|Homo sapiens serum/glucocorticoid re... 157 7e-38
AF169035-1|AAF12758.1| 429|Homo sapiens protein kinase protein. 157 7e-38
AF085233-1|AAF27051.2| 496|Homo sapiens SGK-like protein SGKL p... 157 1e-37
AY098866-1|AAM21719.1| 486|Homo sapiens PKE protein kinase prot... 153 2e-36
AL590105-1|CAI13011.1| 486|Homo sapiens protein kinase (PKE) pr... 153 2e-36
AL512622-1|CAI12181.1| 486|Homo sapiens protein kinase (PKE) pr... 153 2e-36
AL627313-4|CAI14647.1| 578|Homo sapiens ribosomal protein S6 ki... 152 3e-36
M34181-1|AAA60170.1| 351|Homo sapiens cAMP-dependent protein ki... 151 6e-36
DQ667174-1|ABG25919.1| 398|Homo sapiens protein kinase, cAMP-de... 151 6e-36
BC016285-1|AAH16285.1| 257|Homo sapiens protein kinase, cAMP-de... 151 6e-36
AL450063-11|CAI16854.1| 264|Homo sapiens protein kinase, cAMP-d... 151 6e-36
AL450063-7|CAI16850.1| 245|Homo sapiens protein kinase, cAMP-de... 151 6e-36
AL450063-3|CAI16846.1| 398|Homo sapiens protein kinase, cAMP-de... 151 6e-36
AL450063-2|CAI16845.1| 351|Homo sapiens protein kinase, cAMP-de... 151 6e-36
AL450063-1|CAI16844.1| 257|Homo sapiens protein kinase, cAMP-de... 151 6e-36
AL359504-2|CAI14541.1| 351|Homo sapiens protein kinase, cAMP-de... 151 6e-36
AL359504-1|CAI14540.1| 257|Homo sapiens protein kinase, cAMP-de... 151 6e-36
AB209189-1|BAD92426.1| 365|Homo sapiens cAMP-dependent protein ... 151 6e-36
BC035058-1|AAH35058.1| 351|Homo sapiens protein kinase, cAMP-de... 149 3e-35
X07767-1|CAA30597.1| 351|Homo sapiens protein ( Human mRNA for ... 148 5e-35
DQ667173-1|ABG25918.1| 351|Homo sapiens protein kinase, cAMP-de... 148 5e-35
BC108259-1|AAI08260.1| 351|Homo sapiens protein kinase, cAMP-de... 148 5e-35
BC039846-1|AAH39846.1| 351|Homo sapiens protein kinase, cAMP-de... 148 5e-35
AB209475-1|BAD92712.1| 461|Homo sapiens protein kinase C, alpha... 147 1e-34
DQ355971-1|ABC67469.1| 1711|Homo sapiens CDC42 binding protein k... 146 1e-34
BC048261-1|AAH48261.1| 492|Homo sapiens CDC42BPB protein protein. 146 1e-34
BC047871-1|AAH47871.1| 933|Homo sapiens CDC42BPB protein protein. 146 1e-34
AF128625-1|AAD37506.1| 1711|Homo sapiens CDC42-binding protein k... 146 1e-34
AB032950-1|BAA86438.2| 1760|Homo sapiens KIAA1124 protein protein. 146 1e-34
M34182-1|AAC41690.1| 360|Homo sapiens protein kinase A gamma-su... 142 2e-33
DQ667175-1|ABG25920.1| 351|Homo sapiens protein kinase, cAMP-de... 142 2e-33
BC039888-1|AAH39888.1| 351|Homo sapiens protein kinase, cAMP-de... 142 2e-33
AL162730-1|CAH71828.1| 351|Homo sapiens protein kinase, cAMP-de... 142 2e-33
AJ001597-1|CAA04863.1| 351|Homo sapiens cAMP-dependent protein ... 142 2e-33
AY358353-1|AAQ88719.1| 364|Homo sapiens HSA250839 protein. 142 4e-33
AY648038-1|AAT67172.1| 1551|Homo sapiens myotonic dystrophy kina... 141 7e-33
D87931-1|BAA75636.1| 1388|Homo sapiens Rho kinase protein. 140 2e-32
AC018463-2|AAX93049.1| 1337|Homo sapiens unknown protein. 140 2e-32
AB014519-1|BAA31594.2| 1428|Homo sapiens KIAA0619 protein protein. 140 2e-32
U43195-1|AAB02814.1| 1354|Homo sapiens Rho-associated, coiled-co... 139 2e-32
Z92868-1|CAB07437.1| 686|Homo sapiens cGMP-dependent protein ki... 138 5e-32
Z92867-1|CAB07436.1| 671|Homo sapiens cGMP-dependent protein ki... 138 5e-32
Y07512-1|CAA68810.1| 686|Homo sapiens protein ( Human mRNA for ... 138 5e-32
D45864-1|BAA08297.1| 671|Homo sapiens cGMP-dependent protein ki... 138 5e-32
BC127090-1|AAI27091.1| 686|Homo sapiens protein kinase, cGMP-de... 138 5e-32
AL928686-2|CAI40743.1| 686|Homo sapiens protein kinase, cGMP-de... 138 5e-32
AL928686-1|CAI40742.1| 659|Homo sapiens protein kinase, cGMP-de... 138 5e-32
AL731537-3|CAI17115.1| 686|Homo sapiens protein kinase, cGMP-de... 138 5e-32
AL731537-2|CAI17114.1| 659|Homo sapiens protein kinase, cGMP-de... 138 5e-32
AL391378-2|CAI39626.1| 686|Homo sapiens protein kinase, cGMP-de... 138 5e-32
AL391378-1|CAI39625.1| 659|Homo sapiens protein kinase, cGMP-de... 138 5e-32
AL157399-2|CAI41305.1| 686|Homo sapiens protein kinase, cGMP-de... 138 5e-32
AL157399-1|CAI41304.1| 659|Homo sapiens protein kinase, cGMP-de... 138 5e-32
BC062558-1|AAH62558.1| 889|Homo sapiens protein kinase N3 protein. 138 6e-32
AL441992-1|CAI15401.1| 889|Homo sapiens protein kinase N3 protein. 138 6e-32
AY702977-1|AAU29340.1| 643|Homo sapiens protein kinase C theta ... 137 1e-31
BC113114-1|AAI13115.1| 1354|Homo sapiens Rho-associated, coiled-... 134 6e-31
X65293-1|CAA46388.1| 737|Homo sapiens protein kinase C epsilon... 134 8e-31
BC109034-1|AAI09035.1| 737|Homo sapiens protein kinase C, epsil... 134 8e-31
BC109033-1|AAI09034.1| 737|Homo sapiens protein kinase C, epsil... 134 8e-31
AB019692-1|BAA85625.1| 889|Homo sapiens protein kinase PKNbeta ... 134 8e-31
Y15056-1|CAA75341.1| 556|Homo sapiens PkB kinase protein. 133 2e-30
CR536517-1|CAG38755.1| 556|Homo sapiens PDPK1 protein. 133 2e-30
BC012103-1|AAH12103.1| 556|Homo sapiens 3-phosphoinositide depe... 133 2e-30
AY166586-1|AAN86031.1| 1638|Homo sapiens CDC42-binding protein k... 133 2e-30
AF017995-1|AAC51825.1| 556|Homo sapiens 3-phosphoinositide depe... 133 2e-30
AC005591-1|AAC33797.1| 367|Homo sapiens PkB-like protein. 133 2e-30
AB209835-1|BAD93072.1| 492|Homo sapiens 3-phosphoinositide depe... 133 2e-30
S72883-1|AAB31800.1| 625|Homo sapiens myotonin protein kinase p... 132 2e-30
L19268-1|AAA36206.1| 624|Homo sapiens protein kinase protein. 132 2e-30
L08835-5|AAC14450.1| 530|Homo sapiens myotonic dystrophy kinase... 132 2e-30
L08835-4|AAC14451.1| 535|Homo sapiens myotonic dystrophy kinase... 132 2e-30
L08835-3|AAC14448.1| 624|Homo sapiens myotonic dystrophy kinase... 132 2e-30
L08835-2|AAC14449.1| 629|Homo sapiens myotonic dystrophy kinase... 132 2e-30
BC062553-1|AAH62553.1| 629|Homo sapiens DMPK protein protein. 132 2e-30
Z98752-6|CAI42313.1| 198|Homo sapiens serum/glucocorticoid regu... 132 3e-30
U59305-1|AAB37126.1| 496|Homo sapiens ser-thr protein kinase PK... 130 1e-29
M94203-1|AAA64884.1| 582|Homo sapiens protein kinase protein. 130 1e-29
L00727-5|AAA75237.1| 545|Homo sapiens myotonin-protein kinase, ... 130 1e-29
L00727-3|AAA75239.1| 634|Homo sapiens myotonin-protein kinase, ... 130 1e-29
L00727-2|AAA75238.1| 609|Homo sapiens myotonin-protein kinase, ... 130 1e-29
L00727-1|AAA75236.1| 639|Homo sapiens myotonin-protein kinase, ... 130 1e-29
BC026328-1|AAH26328.1| 655|Homo sapiens DMPK protein protein. 130 1e-29
AL627308-5|CAH71336.1| 1732|Homo sapiens CDC42 binding protein k... 130 1e-29
AL627308-4|CAH71338.1| 1638|Homo sapiens CDC42 binding protein k... 130 1e-29
AL627308-3|CAH71337.1| 1719|Homo sapiens CDC42 binding protein k... 130 1e-29
AL451047-3|CAH71185.1| 1732|Homo sapiens CDC42 binding protein k... 130 1e-29
AL451047-2|CAH71184.1| 1638|Homo sapiens CDC42 binding protein k... 130 1e-29
AL451047-1|CAH71183.1| 1719|Homo sapiens CDC42 binding protein k... 130 1e-29
AL353689-9|CAI19109.1| 1732|Homo sapiens CDC42 binding protein k... 130 1e-29
AL353689-8|CAI19110.1| 1638|Homo sapiens CDC42 binding protein k... 130 1e-29
AL353689-7|CAI19108.1| 1719|Homo sapiens CDC42 binding protein k... 130 1e-29
AK222581-1|BAD96301.1| 556|Homo sapiens 3-phosphoinositide depe... 130 1e-29
AJ785968-1|CAH05056.1| 396|Homo sapiens PDPK2 protein protein. 130 1e-29
AJ518976-1|CAD57746.1| 1638|Homo sapiens CDC42 binding protein k... 130 1e-29
AJ518975-1|CAD57745.1| 1719|Homo sapiens CDC42 binding protein k... 130 1e-29
AB209363-1|BAD92600.1| 672|Homo sapiens myotonic dystrophy prot... 130 1e-29
AB208968-1|BAD92205.1| 1702|Homo sapiens CDC42 binding protein k... 130 1e-29
AL450063-6|CAI16849.1| 214|Homo sapiens protein kinase, cAMP-de... 130 1e-29
BC045760-1|AAH45760.1| 369|Homo sapiens STK32C protein protein. 130 2e-29
AY681966-1|AAV87216.1| 2069|Homo sapiens citron protein. 130 2e-29
AY257469-1|AAP13528.1| 2027|Homo sapiens rho/rac-interacting cit... 130 2e-29
AL512622-5|CAI12187.1| 369|Homo sapiens protein kinase (PKE) pr... 130 2e-29
AY209000-1|AAP43922.1| 482|Homo sapiens citron Rho-interacting ... 128 4e-29
AL450063-10|CAI16853.1| 209|Homo sapiens protein kinase, cAMP-d... 128 7e-29
X85545-1|CAA59733.1| 358|Homo sapiens protein kinase protein. 127 9e-29
BC041073-1|AAH41073.1| 358|Homo sapiens protein kinase, X-linke... 127 9e-29
AL450063-9|CAI16852.1| 197|Homo sapiens protein kinase, cAMP-de... 127 1e-28
M80335-1|AAA60094.1| 207|Homo sapiens protein kinase A-alpha pr... 126 3e-28
Y15801-1|CAA75792.1| 277|Homo sapiens protein kinase protein. 124 1e-27
Y13927-1|CAA74244.1| 277|Homo sapiens protein kinase protein. 124 1e-27
BC074852-1|AAH74852.1| 277|Homo sapiens protein kinase, Y-linke... 124 1e-27
BC074851-1|AAH74851.1| 277|Homo sapiens protein kinase, Y-linke... 124 1e-27
Y16106-1|CAA76073.1| 734|Homo sapiens cGMP-dependant protein ki... 122 5e-27
X94612-1|CAA64318.1| 762|Homo sapiens Type II cGMP-dependent pr... 122 5e-27
AL450063-8|CAI16851.1| 206|Homo sapiens protein kinase, cAMP-de... 120 1e-26
D70899-1|BAA18934.1| 762|Homo sapiens cGMP-dependent protein ki... 120 2e-26
BC120995-1|AAI20996.1| 438|Homo sapiens AKT2 protein protein. 119 2e-26
AD000092-1|AAB51171.1| 1237|Homo sapiens hypothetical human seri... 118 4e-26
AB023190-1|BAA76817.1| 1583|Homo sapiens KIAA0973 protein protein. 118 4e-26
AL928686-3|CAI40744.1| 283|Homo sapiens protein kinase, cGMP-de... 118 6e-26
AF208004-1|AAG35720.1| 181|Homo sapiens cAMP-dependent protein ... 117 1e-25
BC015472-1|AAH15472.1| 363|Homo sapiens PRKD2 protein protein. 113 1e-24
AK075266-1|BAC11508.1| 721|Homo sapiens protein ( Homo sapiens ... 113 1e-24
AK074673-1|BAC11127.1| 721|Homo sapiens protein ( Homo sapiens ... 113 1e-24
AF309082-1|AAK01149.1| 878|Homo sapiens protein kinase D2 protein. 113 1e-24
BC065499-1|AAH65499.1| 1797|Homo sapiens microtubule associated ... 113 2e-24
BC015816-1|AAH15816.2| 792|Homo sapiens MAST2 protein protein. 113 2e-24
BC006166-1|AAH06166.1| 792|Homo sapiens MAST2 protein protein. 113 2e-24
AY830839-1|AAW52510.1| 2434|Homo sapiens serine/threonine protei... 113 2e-24
AL645480-2|CAH73245.1| 792|Homo sapiens microtubule associated ... 113 2e-24
AL645480-1|CAH73244.1| 1798|Homo sapiens microtubule associated ... 113 2e-24
AL603888-3|CAI16563.1| 792|Homo sapiens microtubule associated ... 113 2e-24
AL603888-2|CAI16562.1| 1798|Homo sapiens microtubule associated ... 113 2e-24
AL603882-2|CAI16217.1| 1798|Homo sapiens microtubule associated ... 113 2e-24
AL358075-6|CAI21706.1| 792|Homo sapiens microtubule associated ... 113 2e-24
AL358075-5|CAI21705.1| 1798|Homo sapiens microtubule associated ... 113 2e-24
AL022069-1|CAI19650.1| 166|Homo sapiens ribosomal protein S6 ki... 113 2e-24
AB047005-1|BAB40778.1| 1734|Homo sapiens MAST205 protein. 113 2e-24
AB018350-1|BAA34527.2| 1329|Homo sapiens KIAA0807 protein protein. 113 2e-24
AB002301-1|BAA20762.1| 2137|Homo sapiens KIAA0303 protein. 113 2e-24
BC021666-1|AAH21666.1| 166|Homo sapiens serine/threonine kinase... 113 2e-24
X75756-1|CAA53384.1| 912|Homo sapiens protein kinase C mu protein. 112 3e-24
DQ485452-1|ABE96833.1| 914|Homo sapiens protein kinase D1 protein. 112 3e-24
AC005793-1|AAC62830.1| 593|Homo sapiens KIAA0561 protein [AA 1-... 112 3e-24
AB011133-1|BAA25487.1| 1308|Homo sapiens KIAA0561 protein protein. 112 3e-24
AL450063-5|CAI16848.1| 186|Homo sapiens protein kinase, cAMP-de... 112 4e-24
Z85986-3|CAB39180.1| 465|Homo sapiens serine/threonine kinase 3... 111 6e-24
Z35102-1|CAA84485.1| 465|Homo sapiens Ndr protein kinase protein. 111 6e-24
BC095413-1|AAH95413.1| 465|Homo sapiens serine/threonine kinase... 111 6e-24
BC012085-1|AAH12085.1| 465|Homo sapiens serine/threonine kinase... 111 6e-24
D43636-1|BAA07744.2| 766|Homo sapiens KIAA0096 protein. 111 8e-24
BC028603-1|AAH28603.1| 464|Homo sapiens serine/threonine kinase... 111 8e-24
AB023182-1|BAA76809.2| 489|Homo sapiens KIAA0965 protein protein. 111 8e-24
BC071567-1|AAH71567.1| 765|Homo sapiens SNRK protein protein. 109 2e-23
U56998-1|AAC50637.1| 607|Homo sapiens putative serine/threonine... 109 3e-23
BC013899-1|AAH13899.1| 646|Homo sapiens polo-like kinase 3 (Dro... 109 3e-23
AY764184-1|AAU88146.1| 646|Homo sapiens polo-like kinase 3 (Dro... 109 3e-23
AL592166-11|CAI13006.1| 646|Homo sapiens polo-like kinase 3 (Dr... 109 3e-23
AB209875-1|BAD93112.1| 621|Homo sapiens polo-like kinase 3 vari... 109 3e-23
AB051552-1|BAB21856.1| 608|Homo sapiens KIAA1765 protein protein. 109 3e-23
L00727-6|AAA75240.1| 540|Homo sapiens myotonin-protein kinase, ... 109 3e-23
AJ293866-1|CAC10659.1| 646|Homo sapiens FNK serine/threonine pr... 109 3e-23
BC035745-1|AAH35745.1| 385|Homo sapiens calcium/calmodulin-depe... 108 4e-23
AL731559-2|CAI14675.1| 385|Homo sapiens calcium/calmodulin-depe... 108 4e-23
AL731559-1|CAI14674.1| 357|Homo sapiens calcium/calmodulin-depe... 108 4e-23
AL512783-2|CAH74036.1| 385|Homo sapiens calcium/calmodulin-depe... 108 4e-23
AL512783-1|CAH74035.1| 357|Homo sapiens calcium/calmodulin-depe... 108 4e-23
AL512284-2|CAH71694.1| 385|Homo sapiens calcium/calmodulin-depe... 108 4e-23
AL512284-1|CAH71693.1| 357|Homo sapiens calcium/calmodulin-depe... 108 4e-23
AL391314-2|CAI14410.1| 385|Homo sapiens calcium/calmodulin-depe... 108 4e-23
AL391314-1|CAI14409.1| 357|Homo sapiens calcium/calmodulin-depe... 108 4e-23
AF286366-1|AAG00534.1| 357|Homo sapiens CamKI-like protein kina... 108 4e-23
AB081726-1|BAC19846.1| 385|Homo sapiens CaM-kinase I delta prot... 108 4e-23
AF164041-1|AAD50272.1| 1130|Homo sapiens WARTS protein kinase pr... 108 6e-23
AF104413-1|AAD16882.1| 1130|Homo sapiens large tumor suppressor ... 108 6e-23
AB209426-1|BAD92663.1| 830|Homo sapiens LATS homolog 1 variant ... 108 6e-23
AY120867-1|AAM55491.1| 752|Homo sapiens MAP/microtubule affinit... 107 8e-23
AY057448-1|AAL23683.1| 752|Homo sapiens MARK4 serine/threonine ... 107 8e-23
AK075272-1|BAC11510.1| 752|Homo sapiens protein ( Homo sapiens ... 107 8e-23
AC007390-1|AAY14817.1| 890|Homo sapiens unknown protein. 107 8e-23
AB058763-1|BAB47489.1| 689|Homo sapiens KIAA1860 protein protein. 107 8e-23
AB015982-1|BAA36514.1| 890|Homo sapiens serine/threonine kinase... 107 8e-23
AF226044-1|AAF86944.1| 765|Homo sapiens HSNFRK protein. 107 1e-22
AL450063-12|CAI16855.1| 321|Homo sapiens protein kinase, cAMP-d... 107 1e-22
AC017006-1|AAX93253.1| 258|Homo sapiens unknown protein. 106 2e-22
X73458-1|CAA51837.1| 603|Homo sapiens protein kinase protein. 105 4e-22
BC014846-1|AAH14846.1| 603|Homo sapiens polo-like kinase 1 (Dro... 105 4e-22
BC003002-1|AAH03002.1| 603|Homo sapiens polo-like kinase 1 (Dro... 105 4e-22
BC002369-1|AAH02369.1| 603|Homo sapiens polo-like kinase 1 (Dro... 105 4e-22
AB088047-1|BAC03375.1| 752|Homo sapiens microtubule affinity-re... 104 7e-22
AB049127-1|BAB39380.1| 688|Homo sapiens MAP/microtubule affinit... 104 7e-22
AF059681-1|AAC77369.1| 275|Homo sapiens serine/threonine kinase... 104 1e-21
U01038-1|AAA56634.1| 603|Homo sapiens pLK protein. 103 1e-21
L19559-1|AAA36659.1| 603|Homo sapiens protein kinase protein. 103 1e-21
L00727-4|AAA75235.1| 589|Homo sapiens myotonin-protein kinase, ... 103 1e-21
BC075064-1|AAH75064.2| 275|Homo sapiens AURKC protein protein. 103 1e-21
BC032787-1|AAH32787.1| 476|Homo sapiens calcium/calmodulin-depe... 103 1e-21
AY714054-1|AAU04399.1| 306|Homo sapiens aurora-C protein. 103 1e-21
AY661554-1|AAT64422.1| 290|Homo sapiens aurora/Ipl1-related kin... 103 1e-21
AY212935-1|AAP29964.1| 460|Homo sapiens CLICK III protein. 103 1e-21
AL049688-1|CAB41259.1| 481|Homo sapiens hypothetical protein pr... 103 1e-21
AL023754-3|CAI19991.1| 476|Homo sapiens calcium/calmodulin-depe... 103 1e-21
AF428261-1|AAL28100.1| 476|Homo sapiens calcium/calmodulin-depe... 103 1e-21
AF054621-1|AAC25955.1| 309|Homo sapiens serine/threonine kinase... 103 1e-21
AB017332-1|BAA76292.1| 309|Homo sapiens Aurora/Ipl1-related kin... 103 1e-21
BC114478-1|AAI14479.1| 795|Homo sapiens MARK1 protein protein. 103 2e-21
BC113869-1|AAI13870.1| 795|Homo sapiens MARK1 protein protein. 103 2e-21
AL592406-3|CAH72463.1| 795|Homo sapiens MAP/microtubule affinit... 103 2e-21
AK000231-1|BAA91023.1| 244|Homo sapiens protein ( Homo sapiens ... 103 2e-21
AF154845-1|AAF72103.1| 795|Homo sapiens MARK protein. 103 2e-21
Y12337-1|CAA73006.1| 289|Homo sapiens myotonic dystrophy protei... 103 2e-21
X97630-1|CAA66229.1| 745|Homo sapiens serine/threonine protein ... 103 2e-21
CR542222-1|CAG47018.1| 306|Homo sapiens NEK6 protein. 103 2e-21
BT007342-1|AAP36006.1| 755|Homo sapiens MAP/microtubule affinit... 103 2e-21
BC084540-1|AAH84540.1| 724|Homo sapiens MAP/microtubule affinit... 103 2e-21
BC012761-1|AAH12761.1| 313|Homo sapiens NIMA (never in mitosis ... 103 2e-21
BC008771-1|AAH08771.2| 778|Homo sapiens MARK2 protein protein. 103 2e-21
BC004209-1|AAH04209.2| 313|Homo sapiens NEK6 protein protein. 103 2e-21
BC004174-1|AAH04174.2| 313|Homo sapiens NEK6 protein protein. 103 2e-21
BC000101-1|AAH00101.2| 313|Homo sapiens NEK6 protein protein. 103 2e-21
AL356285-1|CAI15861.1| 1088|Homo sapiens LATS, large tumor suppr... 103 2e-21
AL162724-9|CAH70254.1| 313|Homo sapiens NIMA (never in mitosis ... 103 2e-21
AL162724-2|CAH70247.1| 347|Homo sapiens NIMA (never in mitosis ... 103 2e-21
AL161613-1|CAH71526.1| 1088|Homo sapiens LATS, large tumor suppr... 103 2e-21
AL137846-13|CAI10883.1| 313|Homo sapiens NIMA (never in mitosis... 103 2e-21
AL137846-6|CAI10876.1| 347|Homo sapiens NIMA (never in mitosis ... 103 2e-21
AF387638-1|AAK82368.1| 691|Homo sapiens Ser/Thr protein kinase ... 103 2e-21
AF207547-1|AAF80561.1| 1088|Homo sapiens serine/threonine kinase... 103 2e-21
AF087909-1|AAG13417.1| 338|Homo sapiens NIMA-related kinase 6 p... 103 2e-21
AB209897-1|BAD93134.1| 924|Homo sapiens LATS, large tumor suppr... 103 2e-21
AB188493-1|BAD37141.1| 719|Homo sapiens serine/threonine kinase... 103 2e-21
AB028019-1|BAA92381.1| 1046|Homo sapiens large tumor suppressor ... 103 2e-21
AB026289-1|BAA85045.1| 306|Homo sapiens protein kinase SID6-151... 103 2e-21
X75932-1|CAA53536.1| 603|Homo sapiens Serine/Threonine protein ... 102 3e-21
CR542227-1|CAG47023.1| 431|Homo sapiens STK24 protein. 102 3e-21
CR457091-1|CAG33372.1| 306|Homo sapiens NEK6 protein. 102 3e-21
BT019619-1|AAV38425.1| 431|Homo sapiens serine/threonine kinase... 101 5e-21
BC065378-1|AAH65378.1| 431|Homo sapiens serine/threonine kinase... 101 5e-21
BC035578-1|AAH35578.1| 431|Homo sapiens serine/threonine kinase... 101 5e-21
AL356423-3|CAI13115.1| 431|Homo sapiens serine/threonine kinase... 101 5e-21
AL356423-2|CAI13114.1| 443|Homo sapiens serine/threonine kinase... 101 5e-21
AL137249-7|CAI39457.1| 431|Homo sapiens serine/threonine kinase... 101 5e-21
AL137249-3|CAI39453.1| 443|Homo sapiens serine/threonine kinase... 101 5e-21
AF083420-1|AAD42039.1| 443|Homo sapiens brain-specific STE20-li... 101 5e-21
AF024636-1|AAB82560.1| 431|Homo sapiens STE20-like kinase 3 pro... 101 5e-21
AB062450-1|BAB85632.1| 302|Homo sapiens NEK7 protein. 101 7e-21
Y13115-1|CAA73575.1| 970|Homo sapiens serine/threonine protein ... 101 9e-21
Y11950-1|CAA72694.1| 406|Homo sapiens phosphorylase kinase gamm... 101 9e-21
U64205-1|AAC15093.1| 729|Homo sapiens Cdc25C associated protein... 101 9e-21
M31606-1|AAA36442.1| 406|Homo sapiens phosphorylase kinase prot... 101 9e-21
BC036023-1|AAH36023.1| 970|Homo sapiens polo-like kinase 4 (Dro... 101 9e-21
BC024773-1|AAH24773.1| 729|Homo sapiens MAP/microtubule affinit... 101 9e-21
BC002541-1|AAH02541.1| 406|Homo sapiens phosphorylase kinase, g... 101 9e-21
AK131198-1|BAD18393.1| 706|Homo sapiens protein ( Homo sapiens ... 101 9e-21
AF387637-1|AAK82367.1| 744|Homo sapiens Ser/Thr protein kinase ... 101 9e-21
BC026158-1|AAH26158.1| 1315|Homo sapiens serine/threonine kinase... 100 1e-20
BC013879-1|AAH13879.1| 685|Homo sapiens polo-like kinase 2 (Dro... 100 1e-20
AK098163-1|BAC05247.1| 372|Homo sapiens protein ( Homo sapiens ... 100 1e-20
AF223574-1|AAF62897.1| 685|Homo sapiens serum-inducible kinase ... 100 1e-20
AF200815-1|AAF97028.1| 1315|Homo sapiens FUSED serine/threonine ... 100 1e-20
AF059617-1|AAC14573.1| 685|Homo sapiens serum-inducible kinase ... 100 1e-20
AB033104-1|BAA86592.1| 1311|Homo sapiens KIAA1278 protein protein. 100 1e-20
M80359-1|AAA59991.1| 713|Homo sapiens protein p78 protein. 99 2e-20
L41816-1|AAA99458.1| 370|Homo sapiens cam kinase I protein. 99 2e-20
BC106755-1|AAI06756.1| 370|Homo sapiens calcium/calmodulin-depe... 99 2e-20
BC106754-1|AAI06755.1| 370|Homo sapiens calcium/calmodulin-depe... 99 2e-20
BC027464-1|AAH27464.1| 403|Homo sapiens aurora kinase A protein. 99 2e-20
BC017306-1|AAH17306.1| 628|Homo sapiens NUAK family, SNF1-like ... 99 2e-20
BC006423-1|AAH06423.1| 403|Homo sapiens aurora kinase A protein. 99 2e-20
BC002499-1|AAH02499.1| 403|Homo sapiens AURKA protein protein. 99 2e-20
BC001280-1|AAH01280.1| 403|Homo sapiens aurora kinase A protein. 99 2e-20
AL121914-4|CAM45838.1| 347|Homo sapiens aurora kinase A protein. 99 2e-20
AL121914-3|CAC12717.1| 403|Homo sapiens aurora kinase A protein. 99 2e-20
AK131359-1|BAD18511.1| 510|Homo sapiens protein ( Homo sapiens ... 99 2e-20
AK074830-1|BAC11234.1| 628|Homo sapiens protein ( Homo sapiens ... 99 2e-20
AF465413-1|AAL69982.1| 753|Homo sapiens MAP/microtubule affinit... 99 2e-20
AF195947-1|AAF29508.1| 403|Homo sapiens STK15 serine/threonine ... 99 2e-20
AF011468-1|AAC63902.1| 403|Homo sapiens serine/threonine kinase... 99 2e-20
AF008551-1|AAC12708.1| 403|Homo sapiens aurora-related kinase 1... 99 2e-20
BC019916-1|AAH19916.2| 506|Homo sapiens NIMA (never in mitosis ... 100 3e-20
AL139082-7|CAI12895.1| 507|Homo sapiens NIMA (never in mitosis ... 100 3e-20
AF000145-1|AAC15472.1| 884|Homo sapiens germinal center kinase ... 100 3e-20
AB006972-1|BAB69958.1| 970|Homo sapiens Sak protein. 100 3e-20
BC071579-1|AAH71579.1| 873|Homo sapiens MAP4K3 protein protein. 99 4e-20
AF445413-2|AAN75850.1| 873|Homo sapiens MAP4K3 protein. 99 4e-20
AF445413-1|AAN75849.1| 894|Homo sapiens MAP4K3 protein. 99 4e-20
AC007684-1|AAF19240.1| 712|Homo sapiens unknown protein. 99 4e-20
AB072828-1|BAC15599.1| 489|Homo sapiens NIMA-related protein ki... 98 6e-20
AB011109-1|BAA25463.2| 698|Homo sapiens KIAA0537 protein protein. 98 6e-20
CR456418-1|CAG30304.1| 586|Homo sapiens CHEK2 protein. 98 8e-20
BC004207-1|AAH04207.1| 543|Homo sapiens CHK2 checkpoint homolog... 98 8e-20
AY800241-1|AAV41895.1| 543|Homo sapiens CHK2 checkpoint homolog... 98 8e-20
AY551303-1|AAS58464.1| 452|Homo sapiens protein kinase Chk2 tra... 98 8e-20
AY551297-1|AAS58458.1| 586|Homo sapiens protein kinase Chk2 tra... 98 8e-20
AL121825-1|CAH73823.1| 543|Homo sapiens CHK2 checkpoint homolog... 98 8e-20
AL117330-1|CAH73875.1| 543|Homo sapiens CHK2 checkpoint homolog... 98 8e-20
AJ131197-1|CAA10319.1| 543|Homo sapiens protein kinase protein. 98 8e-20
AF174135-1|AAD48504.1| 543|Homo sapiens protein kinase CHK2 pro... 98 8e-20
AF096279-1|AAD11784.1| 543|Homo sapiens HuCds1 kinase protein. 98 8e-20
AF086904-1|AAC83693.1| 543|Homo sapiens protein kinase Chk2 pro... 98 8e-20
L24959-1|AAA18251.1| 473|Homo sapiens calcium/calmodulin depend... 97 1e-19
L17000-1|AAA35639.1| 473|Homo sapiens calcium/calmodulin-depend... 97 1e-19
D30742-1|BAA06403.1| 473|Homo sapiens calmodulin-dependent prot... 97 1e-19
BC025687-1|AAH25687.1| 473|Homo sapiens calcium/calmodulin-depe... 97 1e-19
BC016695-1|AAH16695.2| 503|Homo sapiens CAMK4 protein protein. 97 1e-19
BC009107-1|AAH09107.1| 879|Homo sapiens microtubule associated ... 97 1e-19
AL160291-7|CAI16908.1| 878|Homo sapiens novel protein kinase do... 97 1e-19
AL160291-6|CAI16909.1| 879|Homo sapiens novel protein kinase do... 97 1e-19
AL160291-5|CAI16910.1| 840|Homo sapiens novel protein kinase do... 97 1e-19
AK074804-1|BAC11218.1| 840|Homo sapiens protein ( Homo sapiens ... 97 1e-19
AK027719-1|BAB55321.1| 878|Homo sapiens protein ( Homo sapiens ... 97 1e-19
BC063885-1|AAH63885.1| 708|Homo sapiens NIMA (never in mitosis ... 97 1e-19
BC037303-1|AAH37303.1| 550|Homo sapiens PRKAA1 protein protein. 97 1e-19
AL139082-5|CAI12892.2| 708|Homo sapiens NIMA (never in mitosis ... 97 1e-19
AB022017-1|BAA36547.1| 550|Homo sapiens AMP-activated protein k... 97 1e-19
BC032784-1|AAH32784.1| 478|Homo sapiens calcium/calmodulin-depe... 96 3e-19
AY987011-1|AAX88806.1| 489|Homo sapiens calcium/calmodulin-depe... 96 3e-19
AJ252239-1|CAB65123.1| 243|Homo sapiens calcium/calmodulin depe... 96 3e-19
AF217975-1|AAG17218.1| 322|Homo sapiens unknown protein. 96 3e-19
AB209288-1|BAD92525.1| 522|Homo sapiens calcium/calmodulin-depe... 96 3e-19
X99325-1|CAA67700.1| 426|Homo sapiens Ste20-like kinase protein. 96 3e-19
D63780-1|BAA20420.1| 426|Homo sapiens YSK1 protein. 96 3e-19
DQ093965-1|AAY88740.1| 426|Homo sapiens serine/threonine kinase... 96 3e-19
BT019961-1|AAV38764.1| 426|Homo sapiens serine/threonine kinase... 96 3e-19
BC091505-1|AAH91505.1| 426|Homo sapiens STK25 protein protein. 96 3e-19
BC015793-1|AAH15793.1| 426|Homo sapiens STK25 protein protein. 96 3e-19
>M80776-1|AAA58391.1| 689|Homo sapiens receptor kinase protein.
Length = 689
Score = 762 bits (1885), Expect = 0.0
Identities = 366/526 (69%), Positives = 418/526 (79%), Gaps = 29/526 (5%)
Query: 15 SDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 74
SDK+TRFCQWKN+ELNI LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI
Sbjct: 168 SDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 227
Query: 75 KMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 134
KMKQGETLALNERIMLSLVSTG DCPFIVCM+YAFHTPDKL FILDLMNGGDLHYHLSQH
Sbjct: 228 KMKQGETLALNERIMLSLVSTG-DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH 286
Query: 135 GVFNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKK 194
GVF+EA+M+FYAAE+ILGLEHMH R +VYRDLKPANILLDEHGHVRISDLGLACDFSKKK
Sbjct: 287 GVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK 346
Query: 195 PHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMT 254
PHASVGTHGYMAPEVL KG YDSSADWFS GCML+KLL+GHSPFRQHKTKDKHEID+MT
Sbjct: 347 PHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMT 406
Query: 255 LTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGA 314
LTM +P+SFSP L+SLLEGLLQRD+N+RLGC GRGA
Sbjct: 407 LTMAVE----------------------LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGA 444
Query: 315 DEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQM 374
EVKE FF +DWQ V+ QKY PPLIPPRGEVNAADAFDIGSFDEEDTKGIKL ++DQ
Sbjct: 445 QEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQE 504
Query: 375 QYKDFPLVISERWQAEVAETVFDTVNLEADKLEQKRKAKQKQKFDADEKE--SDCILHGY 432
Y++FPL ISERWQ EVAETVFDT+N E D+LE ++KAK KQ ++ DCI+HGY
Sbjct: 505 LYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGY 564
Query: 433 IKKLGGPFASAWQTRYAKLYPNRLELHLENSAKPEMILLDTVEEVSS-DFVSIKGEQCIV 491
+ K+G PF + WQ RY L+PNRLE E A P+ +L T+EE+ S + IK +C++
Sbjct: 565 MSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEA-PQSLL--TMEEIQSVEETQIKERKCLL 621
Query: 492 LRTRNDTKVVLTNTDEIGLKEWALSLRSAHKCSQELLASMAKKAGK 537
L+ R + +L + L +W LR A++ +Q+L+ + K K
Sbjct: 622 LKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNK 667
>BC090863-1|AAH90863.1| 689|Homo sapiens ADRBK1 protein protein.
Length = 689
Score = 762 bits (1885), Expect = 0.0
Identities = 366/526 (69%), Positives = 418/526 (79%), Gaps = 29/526 (5%)
Query: 15 SDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 74
SDK+TRFCQWKN+ELNI LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI
Sbjct: 168 SDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 227
Query: 75 KMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 134
KMKQGETLALNERIMLSLVSTG DCPFIVCM+YAFHTPDKL FILDLMNGGDLHYHLSQH
Sbjct: 228 KMKQGETLALNERIMLSLVSTG-DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH 286
Query: 135 GVFNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKK 194
GVF+EA+M+FYAAE+ILGLEHMH R +VYRDLKPANILLDEHGHVRISDLGLACDFSKKK
Sbjct: 287 GVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK 346
Query: 195 PHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMT 254
PHASVGTHGYMAPEVL KG YDSSADWFS GCML+KLL+GHSPFRQHKTKDKHEID+MT
Sbjct: 347 PHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMT 406
Query: 255 LTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGA 314
LTM +P+SFSP L+SLLEGLLQRD+N+RLGC GRGA
Sbjct: 407 LTMAVE----------------------LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGA 444
Query: 315 DEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQM 374
EVKE FF +DWQ V+ QKY PPLIPPRGEVNAADAFDIGSFDEEDTKGIKL ++DQ
Sbjct: 445 QEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQE 504
Query: 375 QYKDFPLVISERWQAEVAETVFDTVNLEADKLEQKRKAKQKQKFDADEKE--SDCILHGY 432
Y++FPL ISERWQ EVAETVFDT+N E D+LE ++KAK KQ ++ DCI+HGY
Sbjct: 505 LYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGY 564
Query: 433 IKKLGGPFASAWQTRYAKLYPNRLELHLENSAKPEMILLDTVEEVSS-DFVSIKGEQCIV 491
+ K+G PF + WQ RY L+PNRLE E A P+ +L T+EE+ S + IK +C++
Sbjct: 565 MSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEA-PQSLL--TMEEIQSVEETQIKERKCLL 621
Query: 492 LRTRNDTKVVLTNTDEIGLKEWALSLRSAHKCSQELLASMAKKAGK 537
L+ R + +L + L +W LR A++ +Q+L+ + K K
Sbjct: 622 LKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNK 667
>BC037963-1|AAH37963.1| 689|Homo sapiens adrenergic, beta, receptor
kinase 1 protein.
Length = 689
Score = 762 bits (1885), Expect = 0.0
Identities = 366/526 (69%), Positives = 418/526 (79%), Gaps = 29/526 (5%)
Query: 15 SDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 74
SDK+TRFCQWKN+ELNI LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI
Sbjct: 168 SDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 227
Query: 75 KMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 134
KMKQGETLALNERIMLSLVSTG DCPFIVCM+YAFHTPDKL FILDLMNGGDLHYHLSQH
Sbjct: 228 KMKQGETLALNERIMLSLVSTG-DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH 286
Query: 135 GVFNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKK 194
GVF+EA+M+FYAAE+ILGLEHMH R +VYRDLKPANILLDEHGHVRISDLGLACDFSKKK
Sbjct: 287 GVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK 346
Query: 195 PHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMT 254
PHASVGTHGYMAPEVL KG YDSSADWFS GCML+KLL+GHSPFRQHKTKDKHEID+MT
Sbjct: 347 PHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMT 406
Query: 255 LTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGA 314
LTM +P+SFSP L+SLLEGLLQRD+N+RLGC GRGA
Sbjct: 407 LTMAVE----------------------LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGA 444
Query: 315 DEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQM 374
EVKE FF +DWQ V+ QKY PPLIPPRGEVNAADAFDIGSFDEEDTKGIKL ++DQ
Sbjct: 445 QEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQE 504
Query: 375 QYKDFPLVISERWQAEVAETVFDTVNLEADKLEQKRKAKQKQKFDADEKE--SDCILHGY 432
Y++FPL ISERWQ EVAETVFDT+N E D+LE ++KAK KQ ++ DCI+HGY
Sbjct: 505 LYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGY 564
Query: 433 IKKLGGPFASAWQTRYAKLYPNRLELHLENSAKPEMILLDTVEEVSS-DFVSIKGEQCIV 491
+ K+G PF + WQ RY L+PNRLE E A P+ +L T+EE+ S + IK +C++
Sbjct: 565 MSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEA-PQSLL--TMEEIQSVEETQIKERKCLL 621
Query: 492 LRTRNDTKVVLTNTDEIGLKEWALSLRSAHKCSQELLASMAKKAGK 537
L+ R + +L + L +W LR A++ +Q+L+ + K K
Sbjct: 622 LKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNK 667
>X61157-1|CAA43470.1| 689|Homo sapiens beta-adrenergic receptor
kinase protein.
Length = 689
Score = 758 bits (1874), Expect = 0.0
Identities = 364/526 (69%), Positives = 416/526 (79%), Gaps = 29/526 (5%)
Query: 15 SDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 74
SDK+TRFCQWKN+ELNI LTMNDFSVHRIIGRGGFGEVYGCRK DTGKMYAMKCLDKKRI
Sbjct: 168 SDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKRDTGKMYAMKCLDKKRI 227
Query: 75 KMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 134
KMKQGETLALNERIMLSLVSTG DCPFIVCM+YAFHTPDKL FILDLMNGGDLHYHLSQH
Sbjct: 228 KMKQGETLALNERIMLSLVSTG-DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH 286
Query: 135 GVFNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKK 194
GVF+EA+M+FYAAE+ILGLEHMH R +VYRDLKPANILLDEHGHVRISDLGLACDFSKKK
Sbjct: 287 GVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK 346
Query: 195 PHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMT 254
PHASVGTHGYMAPEVL KG YDSSADWFS GCML+KLL+GHSPFRQHKTKDKHEID+MT
Sbjct: 347 PHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMT 406
Query: 255 LTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGA 314
LTM +P+SFSP L SLLEGLLQRD+N+RLGC GRGA
Sbjct: 407 LTMAVE----------------------LPDSFSPELHSLLEGLLQRDVNRRLGCLGRGA 444
Query: 315 DEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQM 374
EVKE FF +DWQ V+ Q+Y PPLIPPRGEVNAADAFDIGSFDEEDTKGIKL ++DQ
Sbjct: 445 QEVKESPFFRSLDWQMVFLQRYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQE 504
Query: 375 QYKDFPLVISERWQAEVAETVFDTVNLEADKLEQKRKAKQKQKFDADEKE--SDCILHGY 432
Y++FPL ISERWQ EVAETVFDT+N E D+LE ++KAK KQ ++ DCI+HGY
Sbjct: 505 LYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGY 564
Query: 433 IKKLGGPFASAWQTRYAKLYPNRLELHLENSAKPEMILLDTVEEVSS-DFVSIKGEQCIV 491
+ K+G PF + WQ RY L+PNRLE E A P+ +L T+EE+ S + IK +C++
Sbjct: 565 MSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEA-PQSLL--TMEEIQSVEETQIKERKCLL 621
Query: 492 LRTRNDTKVVLTNTDEIGLKEWALSLRSAHKCSQELLASMAKKAGK 537
L+ R + +L + L +W LR A++ +Q+L+ + K K
Sbjct: 622 LKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNK 667
>AL022329-1|CAB45657.1| 688|Homo sapiens adrenergic, beta, receptor
kinase 2 protein.
Length = 688
Score = 752 bits (1859), Expect = 0.0
Identities = 358/525 (68%), Positives = 408/525 (77%), Gaps = 27/525 (5%)
Query: 15 SDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 74
SDK+TRFCQWKN+ELNI LTMN+FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI
Sbjct: 168 SDKFTRFCQWKNVELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 227
Query: 75 KMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 134
KMKQGETLALNERIMLSLVSTG DCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH
Sbjct: 228 KMKQGETLALNERIMLSLVSTG-DCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 286
Query: 135 GVFNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKK 194
GVF+E EM+FYA E+ILGLEHMH R +VYRDLKPANILLDEHGH RISDLGLACDFSKKK
Sbjct: 287 GVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKK 346
Query: 195 PHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMT 254
PHASVGTHGYMAPEVL KGT YDSSADWFS GCML+KLL+GHSPFRQHKTKDKHEID+MT
Sbjct: 347 PHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMT 406
Query: 255 LTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGA 314
LT+ +P++FSP LKSLLEGLLQRD++KRLGC G G+
Sbjct: 407 LTV----------------------NVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGS 444
Query: 315 DEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQM 374
EVKEH FF G+DWQ VY QKY PPLIPPRGEVNAADAFDIGSFDEEDTKGIKL + DQ
Sbjct: 445 QEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQE 504
Query: 375 QYKDFPLVISERWQAEVAETVFDTVNLEADKLEQKRKAKQKQKFDADEKE--SDCILHGY 432
YK+FPLVISERWQ EV ETV++ VN + DK+E +++AK KQ ++ DCI+HGY
Sbjct: 505 LYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGY 564
Query: 433 IKKLGGPFASAWQTRYAKLYPNRLELHLENSAKPEMILLDTVEEVSSDFVSIKGEQCIVL 492
+ KLG PF + WQ RY L+PNRLE E ++ ++ ++ + +S + IK ++CI+
Sbjct: 565 MLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNLLTMEQI--LSVEETQIKDKKCILF 622
Query: 493 RTRNDTKVVLTNTDEIGLKEWALSLRSAHKCSQELLASMAKKAGK 537
R + + VL + +W L K +Q LL K K
Sbjct: 623 RIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNK 667
>X69117-1|CAA48870.1| 688|Homo sapiens beta-adrenergic kinase 2
protein.
Length = 688
Score = 750 bits (1855), Expect = 0.0
Identities = 357/525 (68%), Positives = 408/525 (77%), Gaps = 27/525 (5%)
Query: 15 SDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 74
SDK+TRFCQWKN+ELNI LTMN+FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI
Sbjct: 168 SDKFTRFCQWKNVELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 227
Query: 75 KMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 134
KMKQGETLALNERIMLSLVSTG DCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH
Sbjct: 228 KMKQGETLALNERIMLSLVSTG-DCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 286
Query: 135 GVFNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKK 194
GVF+E EM+FYA E+ILGLEH+H R +VYRDLKPANILLDEHGH RISDLGLACDFSKKK
Sbjct: 287 GVFSEKEMRFYATEIILGLEHVHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKK 346
Query: 195 PHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMT 254
PHASVGTHGYMAPEVL KGT YDSSADWFS GCML+KLL+GHSPFRQHKTKDKHEID+MT
Sbjct: 347 PHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMT 406
Query: 255 LTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGA 314
LT+ +P++FSP LKSLLEGLLQRD++KRLGC G G+
Sbjct: 407 LTV----------------------NVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGS 444
Query: 315 DEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQM 374
EVKEH FF G+DWQ VY QKY PPLIPPRGEVNAADAFDIGSFDEEDTKGIKL + DQ
Sbjct: 445 QEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQE 504
Query: 375 QYKDFPLVISERWQAEVAETVFDTVNLEADKLEQKRKAKQKQKFDADEKE--SDCILHGY 432
YK+FPLVISERWQ EV ETV++ VN + DK+E +++AK KQ ++ DCI+HGY
Sbjct: 505 LYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGY 564
Query: 433 IKKLGGPFASAWQTRYAKLYPNRLELHLENSAKPEMILLDTVEEVSSDFVSIKGEQCIVL 492
+ KLG PF + WQ RY L+PNRLE E ++ ++ ++ + +S + IK ++CI+
Sbjct: 565 MLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNLLTMEQI--LSVEETQIKDKKCILF 622
Query: 493 RTRNDTKVVLTNTDEIGLKEWALSLRSAHKCSQELLASMAKKAGK 537
R + + VL + +W L K +Q LL K K
Sbjct: 623 RIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNK 667
>U08438-1|AAB60689.1| 689|Homo sapiens beta-adrenergic receptor
kinase protein.
Length = 689
Score = 723 bits (1787), Expect = 0.0
Identities = 350/508 (68%), Positives = 399/508 (78%), Gaps = 29/508 (5%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
LTMNDFSVHRIIGRGGFGEVYGCRK DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL
Sbjct: 186 LTMNDFSVHRIIGRGGFGEVYGCRKRDTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
VSTG DCPFIVCM+YAFHTPDKL FILDLMNGGDLHYHLSQHGVF+EA+M+FYAAE+ILG
Sbjct: 246 VSTG-DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLSK 212
LEHMH R +VYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVL K
Sbjct: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQK 364
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXA 272
G YDSSADWFS GCML+KLL+GHSPFRQHKTKDKHEID+MTLTM
Sbjct: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE------------ 412
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+P+SFSP L SLLEGLLQRD+N+RLGC GRGA EVKE FF +DWQ V+
Sbjct: 413 ----------LPDSFSPELHSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVF 462
Query: 333 HQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDFPLVISERWQAEVA 392
QKY PPLIPPRGEVNAADAFDIGSFDEEDTKGIKL ++DQ Y++FPL ISERWQ EVA
Sbjct: 463 LQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVA 522
Query: 393 ETVFDTVNLEADKLEQKRKAKQKQKFDADEKE--SDCILHGYIKKLGGPFASAWQTRYAK 450
ETVFDT+N E D+LE ++KAK KQ ++ DCI+HGY+ K+G PF + WQ RY
Sbjct: 523 ETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFY 582
Query: 451 LYPNRLELHLENSAKPEMILLDTVEEVSS-DFVSIKGEQCIVLRTRNDTKVVLTNTDEIG 509
L+PNRLE E A P+ +L T+EE+ S + IK +C++L+ R + +L +
Sbjct: 583 LFPNRLEWRGEGEA-PQSLL--TMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPE 639
Query: 510 LKEWALSLRSAHKCSQELLASMAKKAGK 537
L +W LR A++ +Q+L+ + K K
Sbjct: 640 LVQWKKELRDAYREAQQLVQRVPKMKNK 667
>BC036797-1|AAH36797.1| 387|Homo sapiens ADRBK2 protein protein.
Length = 387
Score = 449 bits (1106), Expect = e-125
Identities = 202/221 (91%), Positives = 211/221 (95%), Gaps = 1/221 (0%)
Query: 15 SDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 74
SDK+TRFCQWKN+ELNI LTMN+FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI
Sbjct: 168 SDKFTRFCQWKNVELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 227
Query: 75 KMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 134
KMKQGETLALNERIMLSLVSTG DCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH
Sbjct: 228 KMKQGETLALNERIMLSLVSTG-DCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 286
Query: 135 GVFNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKK 194
GVF+E EM+FYA E+ILGLEHMH R +VYRDLKPANILLDEHGH RISDLGLACDFSKKK
Sbjct: 287 GVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKK 346
Query: 195 PHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKG 235
PHASVGTHGYMAPEVL KGT YDSSADWFS GCML+KLL+G
Sbjct: 347 PHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRG 387
>AB209588-1|BAD92825.1| 360|Homo sapiens beta adrenergic receptor
kinase 1 variant protein.
Length = 360
Score = 389 bits (957), Expect = e-107
Identities = 195/346 (56%), Positives = 240/346 (69%), Gaps = 28/346 (8%)
Query: 195 PHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMT 254
P + GTHGYMAPEVL KG YDSSADWFS GCML+KLL+GHSPFRQHKTKDKHEID+MT
Sbjct: 18 PCSHRGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMT 77
Query: 255 LTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGA 314
LTM +P+SFSP L+SLLEGLLQRD+N+RLGC GRGA
Sbjct: 78 LTMAVE----------------------LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGA 115
Query: 315 DEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQM 374
EVKE FF +DWQ V+ QKY PPLIPPRGEVNAADAFDIGSFDEEDTKGIKL ++DQ
Sbjct: 116 QEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQE 175
Query: 375 QYKDFPLVISERWQAEVAETVFDTVNLEADKLEQKRKAKQKQKFDADEKE--SDCILHGY 432
Y++FPL ISERWQ EVAETVFDT+N E D+LE ++KAK KQ ++ DCI+HGY
Sbjct: 176 LYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGY 235
Query: 433 IKKLGGPFASAWQTRYAKLYPNRLELHLENSAKPEMILLDTVEEVSS-DFVSIKGEQCIV 491
+ K+G PF + WQ RY L+PNRLE E A P+ +L T+EE+ S + IK +C++
Sbjct: 236 MSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEA-PQSLL--TMEEIQSVEETQIKERKCLL 292
Query: 492 LRTRNDTKVVLTNTDEIGLKEWALSLRSAHKCSQELLASMAKKAGK 537
L+ R + +L + L +W LR A++ +Q+L+ + K K
Sbjct: 293 LKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNK 338
>U00686-1|AAA03565.1| 544|Homo sapiens putative novel receptor
kinase protein.
Length = 544
Score = 284 bits (697), Expect = 5e-76
Identities = 166/389 (42%), Positives = 221/389 (56%), Gaps = 34/389 (8%)
Query: 18 YTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK 77
+ RF QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK +
Sbjct: 135 FNRFLQWKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKR 193
Query: 78 QGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV- 136
+GE +ALNE+ +L V++ F+V + YA+ T D LC +L LMNGGDL +H+ G
Sbjct: 194 KGEAMALNEKQILEKVNSR----FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA 249
Query: 137 -FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP 195
F EA FYAAE+ GLE +H+ IVYRDLKP NILLD+HGH+RISDLGLA + +
Sbjct: 250 GFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT 309
Query: 196 -HASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMT 254
VGT GYMAPEV+ K Y S DW++ GC+LY+++ G SPF+Q K K K E
Sbjct: 310 IKGRVGTVGYMAPEVV-KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKRE----- 363
Query: 255 LTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGA 314
+ E E FSP +SL LL +D +RLGC+G A
Sbjct: 364 ----------------EVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSA 407
Query: 315 DEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQM 374
EVKEH F ++++++ PP P + D DI F KG++L TDQ
Sbjct: 408 REVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQF--STVKGVELEPTDQD 465
Query: 375 QYKDFPL-VISERWQAEVAET-VFDTVNL 401
Y+ F + WQ E+ ET F +N+
Sbjct: 466 FYQKFATGSVPIPWQNEMVETECFQELNV 494
>L16862-1|AAA60175.1| 576|Homo sapiens G protein-coupled receptor
kinase protein.
Length = 576
Score = 284 bits (697), Expect = 5e-76
Identities = 166/389 (42%), Positives = 221/389 (56%), Gaps = 34/389 (8%)
Query: 18 YTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK 77
+ RF QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK +
Sbjct: 167 FNRFLQWKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKR 225
Query: 78 QGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV- 136
+GE +ALNE+ +L V++ F+V + YA+ T D LC +L LMNGGDL +H+ G
Sbjct: 226 KGEAMALNEKQILEKVNSR----FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA 281
Query: 137 -FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP 195
F EA FYAAE+ GLE +H+ IVYRDLKP NILLD+HGH+RISDLGLA + +
Sbjct: 282 GFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT 341
Query: 196 -HASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMT 254
VGT GYMAPEV+ K Y S DW++ GC+LY+++ G SPF+Q K K K E
Sbjct: 342 IKGRVGTVGYMAPEVV-KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKRE----- 395
Query: 255 LTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGA 314
+ E E FSP +SL LL +D +RLGC+G A
Sbjct: 396 ----------------EVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSA 439
Query: 315 DEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQM 374
EVKEH F ++++++ PP P + D DI F KG++L TDQ
Sbjct: 440 REVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQF--STVKGVELEPTDQD 497
Query: 375 QYKDFPL-VISERWQAEVAET-VFDTVNL 401
Y+ F + WQ E+ ET F +N+
Sbjct: 498 FYQKFATGSVPIPWQNEMVETECFQELNV 526
>BC009277-1|AAH09277.1| 576|Homo sapiens G protein-coupled receptor
kinase 6 protein.
Length = 576
Score = 284 bits (697), Expect = 5e-76
Identities = 166/389 (42%), Positives = 221/389 (56%), Gaps = 34/389 (8%)
Query: 18 YTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK 77
+ RF QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK +
Sbjct: 167 FNRFLQWKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKR 225
Query: 78 QGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV- 136
+GE +ALNE+ +L V++ F+V + YA+ T D LC +L LMNGGDL +H+ G
Sbjct: 226 KGEAMALNEKQILEKVNSR----FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA 281
Query: 137 -FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP 195
F EA FYAAE+ GLE +H+ IVYRDLKP NILLD+HGH+RISDLGLA + +
Sbjct: 282 GFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT 341
Query: 196 -HASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMT 254
VGT GYMAPEV+ K Y S DW++ GC+LY+++ G SPF+Q K K K E
Sbjct: 342 IKGRVGTVGYMAPEVV-KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKRE----- 395
Query: 255 LTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGA 314
+ E E FSP +SL LL +D +RLGC+G A
Sbjct: 396 ----------------EVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSA 439
Query: 315 DEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQM 374
EVKEH F ++++++ PP P + D DI F KG++L TDQ
Sbjct: 440 REVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQF--STVKGVELEPTDQD 497
Query: 375 QYKDFPL-VISERWQAEVAET-VFDTVNL 401
Y+ F + WQ E+ ET F +N+
Sbjct: 498 FYQKFATGSVPIPWQNEMVETECFQELNV 526
>AF040752-1|AAC09274.1| 560|Homo sapiens G protein-coupled receptor
kinase 6, splice variant C protein.
Length = 560
Score = 284 bits (697), Expect = 5e-76
Identities = 166/389 (42%), Positives = 221/389 (56%), Gaps = 34/389 (8%)
Query: 18 YTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK 77
+ RF QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK +
Sbjct: 167 FNRFLQWKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKR 225
Query: 78 QGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV- 136
+GE +ALNE+ +L V++ F+V + YA+ T D LC +L LMNGGDL +H+ G
Sbjct: 226 KGEAMALNEKQILEKVNSR----FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA 281
Query: 137 -FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP 195
F EA FYAAE+ GLE +H+ IVYRDLKP NILLD+HGH+RISDLGLA + +
Sbjct: 282 GFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT 341
Query: 196 -HASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMT 254
VGT GYMAPEV+ K Y S DW++ GC+LY+++ G SPF+Q K K K E
Sbjct: 342 IKGRVGTVGYMAPEVV-KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKRE----- 395
Query: 255 LTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGA 314
+ E E FSP +SL LL +D +RLGC+G A
Sbjct: 396 ----------------EVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSA 439
Query: 315 DEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQM 374
EVKEH F ++++++ PP P + D DI F KG++L TDQ
Sbjct: 440 REVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQF--STVKGVELEPTDQD 497
Query: 375 QYKDFPL-VISERWQAEVAET-VFDTVNL 401
Y+ F + WQ E+ ET F +N+
Sbjct: 498 FYQKFATGSVPIPWQNEMVETECFQELNV 526
>AF040751-1|AAC09273.1| 589|Homo sapiens G protein-coupled receptor
kinase 6, splice variant B protein.
Length = 589
Score = 284 bits (697), Expect = 5e-76
Identities = 166/389 (42%), Positives = 221/389 (56%), Gaps = 34/389 (8%)
Query: 18 YTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK 77
+ RF QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK +
Sbjct: 167 FNRFLQWKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKR 225
Query: 78 QGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV- 136
+GE +ALNE+ +L V++ F+V + YA+ T D LC +L LMNGGDL +H+ G
Sbjct: 226 KGEAMALNEKQILEKVNSR----FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA 281
Query: 137 -FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP 195
F EA FYAAE+ GLE +H+ IVYRDLKP NILLD+HGH+RISDLGLA + +
Sbjct: 282 GFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT 341
Query: 196 -HASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMT 254
VGT GYMAPEV+ K Y S DW++ GC+LY+++ G SPF+Q K K K E
Sbjct: 342 IKGRVGTVGYMAPEVV-KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKRE----- 395
Query: 255 LTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGA 314
+ E E FSP +SL LL +D +RLGC+G A
Sbjct: 396 ----------------EVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSA 439
Query: 315 DEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQM 374
EVKEH F ++++++ PP P + D DI F KG++L TDQ
Sbjct: 440 REVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQF--STVKGVELEPTDQD 497
Query: 375 QYKDFPL-VISERWQAEVAET-VFDTVNL 401
Y+ F + WQ E+ ET F +N+
Sbjct: 498 FYQKFATGSVPIPWQNEMVETECFQELNV 526
>BC017272-1|AAH17272.1| 589|Homo sapiens G protein-coupled receptor
kinase 6 protein.
Length = 589
Score = 283 bits (695), Expect = 9e-76
Identities = 166/389 (42%), Positives = 220/389 (56%), Gaps = 34/389 (8%)
Query: 18 YTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK 77
+ RF QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK +
Sbjct: 167 FNRFLQWKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKR 225
Query: 78 QGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV- 136
+GE +ALNE+ +L V++ F+V + YA+ T D LC +L LMNGGDL +H+ G
Sbjct: 226 KGEAMALNEKQILEKVNSR----FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA 281
Query: 137 -FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP 195
F EA FYAAE+ GLE +H+ IVYRDLKP NILLD+HGH+RISDLGLA + +
Sbjct: 282 GFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT 341
Query: 196 -HASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMT 254
VGT GYMAPEV+ K Y S DW++ GC LY+++ G SPF+Q K K K E
Sbjct: 342 IKGRVGTVGYMAPEVV-KNERYTFSPDWWALGCFLYEMIAGQSPFQQRKKKIKRE----- 395
Query: 255 LTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGA 314
+ E E FSP +SL LL +D +RLGC+G A
Sbjct: 396 ----------------EVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSA 439
Query: 315 DEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQM 374
EVKEH F ++++++ PP P + D DI F KG++L TDQ
Sbjct: 440 REVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQF--STVKGVELEPTDQD 497
Query: 375 QYKDFPL-VISERWQAEVAET-VFDTVNL 401
Y+ F + WQ E+ ET F +N+
Sbjct: 498 FYQKFATGSVPIPWQNEMVETECFQELNV 526
>L15388-1|AAA58620.1| 590|Homo sapiens G protein-coupled receptor
kinase protein.
Length = 590
Score = 277 bits (679), Expect = 8e-74
Identities = 160/382 (41%), Positives = 218/382 (57%), Gaps = 35/382 (9%)
Query: 18 YTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK 77
+ RF QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK +
Sbjct: 167 FDRFLQWKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKR 225
Query: 78 QGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV- 136
+GE++ALNE+ +L V++ F+V + YA+ T D LC +L +MNGGDL +H+ G
Sbjct: 226 KGESMALNEKQILEKVNS----QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNP 281
Query: 137 -FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSK-KK 194
F E FYAAE++ GLE +H+ + VYRDLKP NILLD++GH+RISDLGLA +
Sbjct: 282 GFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL 341
Query: 195 PHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDK-HEIDKM 253
VGT GYMAPEVL+ Y S D++ GC++Y++++G SPFR K K K E+D+
Sbjct: 342 IRGRVGTVGYMAPEVLN-NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRR 400
Query: 254 TLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRG 313
L E E FS KS+ + LL +D +RLGC+ G
Sbjct: 401 VL----------------------ETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEG 438
Query: 314 ADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQ 373
A EVK H FF ++++++ PP +P V D DI F KG+ L TD
Sbjct: 439 AAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQF--STVKGVNLDHTDD 496
Query: 374 MQYKDFPL-VISERWQAEVAET 394
Y F +S WQ E+ ET
Sbjct: 497 DFYSKFSTGSVSIPWQNEMIET 518
>BC064506-1|AAH64506.1| 590|Homo sapiens G protein-coupled receptor
kinase 5 protein.
Length = 590
Score = 277 bits (679), Expect = 8e-74
Identities = 160/382 (41%), Positives = 218/382 (57%), Gaps = 35/382 (9%)
Query: 18 YTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK 77
+ RF QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK +
Sbjct: 167 FDRFLQWKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKR 225
Query: 78 QGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV- 136
+GE++ALNE+ +L V++ F+V + YA+ T D LC +L +MNGGDL +H+ G
Sbjct: 226 KGESMALNEKQILEKVNS----QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNP 281
Query: 137 -FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSK-KK 194
F E FYAAE++ GLE +H+ + VYRDLKP NILLD++GH+RISDLGLA +
Sbjct: 282 GFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL 341
Query: 195 PHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDK-HEIDKM 253
VGT GYMAPEVL+ Y S D++ GC++Y++++G SPFR K K K E+D+
Sbjct: 342 IRGRVGTVGYMAPEVLN-NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRR 400
Query: 254 TLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRG 313
L E E FS KS+ + LL +D +RLGC+ G
Sbjct: 401 VL----------------------ETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEG 438
Query: 314 ADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQ 373
A EVK H FF ++++++ PP +P V D DI F KG+ L TD
Sbjct: 439 AAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQF--STVKGVNLDHTDD 496
Query: 374 MQYKDFPL-VISERWQAEVAET 394
Y F +S WQ E+ ET
Sbjct: 497 DFYSKFSTGSVSIPWQNEMIET 518
>AL583824-2|CAI16759.1| 590|Homo sapiens G protein-coupled receptor
kinase 5 protein.
Length = 590
Score = 277 bits (679), Expect = 8e-74
Identities = 160/382 (41%), Positives = 218/382 (57%), Gaps = 35/382 (9%)
Query: 18 YTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK 77
+ RF QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK +
Sbjct: 167 FDRFLQWKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKR 225
Query: 78 QGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV- 136
+GE++ALNE+ +L V++ F+V + YA+ T D LC +L +MNGGDL +H+ G
Sbjct: 226 KGESMALNEKQILEKVNS----QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNP 281
Query: 137 -FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSK-KK 194
F E FYAAE++ GLE +H+ + VYRDLKP NILLD++GH+RISDLGLA +
Sbjct: 282 GFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL 341
Query: 195 PHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDK-HEIDKM 253
VGT GYMAPEVL+ Y S D++ GC++Y++++G SPFR K K K E+D+
Sbjct: 342 IRGRVGTVGYMAPEVLN-NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRR 400
Query: 254 TLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRG 313
L E E FS KS+ + LL +D +RLGC+ G
Sbjct: 401 VL----------------------ETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEG 438
Query: 314 ADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQ 373
A EVK H FF ++++++ PP +P V D DI F KG+ L TD
Sbjct: 439 AAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQF--STVKGVNLDHTDD 496
Query: 374 MQYKDFPL-VISERWQAEVAET 394
Y F +S WQ E+ ET
Sbjct: 497 DFYSKFSTGSVSIPWQNEMIET 518
>AL355861-4|CAI15804.1| 590|Homo sapiens G protein-coupled receptor
kinase 5 protein.
Length = 590
Score = 277 bits (679), Expect = 8e-74
Identities = 160/382 (41%), Positives = 218/382 (57%), Gaps = 35/382 (9%)
Query: 18 YTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK 77
+ RF QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK +
Sbjct: 167 FDRFLQWKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKR 225
Query: 78 QGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV- 136
+GE++ALNE+ +L V++ F+V + YA+ T D LC +L +MNGGDL +H+ G
Sbjct: 226 KGESMALNEKQILEKVNS----QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNP 281
Query: 137 -FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSK-KK 194
F E FYAAE++ GLE +H+ + VYRDLKP NILLD++GH+RISDLGLA +
Sbjct: 282 GFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL 341
Query: 195 PHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDK-HEIDKM 253
VGT GYMAPEVL+ Y S D++ GC++Y++++G SPFR K K K E+D+
Sbjct: 342 IRGRVGTVGYMAPEVLN-NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRR 400
Query: 254 TLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRG 313
L E E FS KS+ + LL +D +RLGC+ G
Sbjct: 401 VL----------------------ETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEG 438
Query: 314 ADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQ 373
A EVK H FF ++++++ PP +P V D DI F KG+ L TD
Sbjct: 439 AAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQF--STVKGVNLDHTDD 496
Query: 374 MQYKDFPL-VISERWQAEVAET 394
Y F +S WQ E+ ET
Sbjct: 497 DFYSKFSTGSVSIPWQNEMIET 518
>AL355273-2|CAI16487.1| 590|Homo sapiens G protein-coupled receptor
kinase 5 protein.
Length = 590
Score = 277 bits (679), Expect = 8e-74
Identities = 160/382 (41%), Positives = 218/382 (57%), Gaps = 35/382 (9%)
Query: 18 YTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK 77
+ RF QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK +
Sbjct: 167 FDRFLQWKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKR 225
Query: 78 QGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV- 136
+GE++ALNE+ +L V++ F+V + YA+ T D LC +L +MNGGDL +H+ G
Sbjct: 226 KGESMALNEKQILEKVNS----QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNP 281
Query: 137 -FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSK-KK 194
F E FYAAE++ GLE +H+ + VYRDLKP NILLD++GH+RISDLGLA +
Sbjct: 282 GFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL 341
Query: 195 PHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDK-HEIDKM 253
VGT GYMAPEVL+ Y S D++ GC++Y++++G SPFR K K K E+D+
Sbjct: 342 IRGRVGTVGYMAPEVLN-NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRR 400
Query: 254 TLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRG 313
L E E FS KS+ + LL +D +RLGC+ G
Sbjct: 401 VL----------------------ETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEG 438
Query: 314 ADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQ 373
A EVK H FF ++++++ PP +P V D DI F KG+ L TD
Sbjct: 439 AAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQF--STVKGVNLDHTDD 496
Query: 374 MQYKDFPL-VISERWQAEVAET 394
Y F +S WQ E+ ET
Sbjct: 497 DFYSKFSTGSVSIPWQNEMIET 518
>AK131506-1|BAD18650.1| 251|Homo sapiens protein ( Homo sapiens
cDNA FLJ16718 fis, clone UTERU3000738, highly similar
to Beta-adrenergic receptor kinase 1 (EC 2.7.1.126). ).
Length = 251
Score = 275 bits (675), Expect = 2e-73
Identities = 131/149 (87%), Positives = 137/149 (91%), Gaps = 4/149 (2%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS
Sbjct: 36 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 95
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
LVSTG DCPFIVCM+YAFHTPDKL FILDLMNGGDLHYHLSQHGVF+EA+M+FYAAE+IL
Sbjct: 96 LVSTG-DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 154
Query: 152 GLEHMHKRHIVYRDLK---PANILLDEHG 177
GLEHMH R +VYRDLK PA LD G
Sbjct: 155 GLEHMHNRFVVYRDLKVSAPAVPRLDLRG 183
>U33168-3|AAC50409.1| 546|Homo sapiens G protein-coupled receptor
kinase GRK4-beta protein.
Length = 546
Score = 273 bits (670), Expect = 9e-73
Identities = 161/392 (41%), Positives = 224/392 (57%), Gaps = 36/392 (9%)
Query: 15 SDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 74
S +++F QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L KKRI
Sbjct: 133 SSYFSQFLQWKWLERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRI 191
Query: 75 KMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 134
K ++GE +ALNE+ +L V + FIV + YA+ T D LC +L +MNGGDL +H+
Sbjct: 192 KKRKGEAMALNEKRILEKVQSR----FIVSLAYAYETKDALCLVLTIMNGGDLKFHIYNL 247
Query: 135 GV--FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSK 192
G F+E FYAAE+ GLE + + IVYRDLKP NILLD+ GH+RISDLGLA + +
Sbjct: 248 GNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPE 307
Query: 193 -KKPHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDK-HEI 250
++ VGT GYMAPEV++ Y S DW+ GC++Y++++GHSPF+++K K K E+
Sbjct: 308 GQRVRGRVGTVGYMAPEVVN-NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEV 366
Query: 251 DKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCK 310
D+ ++N E FS KS+ LL ++ +KRLGC+
Sbjct: 367 DQ----RIKNDTEEYS------------------EKFSEDAKSICRMLLTKNPSKRLGCR 404
Query: 311 GRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTE 370
G GA VK+H F I+++++ PP P V D DI F KGI L
Sbjct: 405 GEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSA--VKGIYLDT 462
Query: 371 TDQMQYKDFPL-VISERWQAEVAET-VFDTVN 400
D+ Y F +S WQ E+ E+ F +N
Sbjct: 463 ADEDFYARFATGCVSIPWQNEMIESGCFKDIN 494
>U33168-1|AAC50410.1| 578|Homo sapiens G protein-coupled receptor
kinase GRK4-alpha protein.
Length = 578
Score = 273 bits (670), Expect = 9e-73
Identities = 161/392 (41%), Positives = 224/392 (57%), Gaps = 36/392 (9%)
Query: 15 SDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 74
S +++F QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L KKRI
Sbjct: 165 SSYFSQFLQWKWLERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRI 223
Query: 75 KMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 134
K ++GE +ALNE+ +L V + FIV + YA+ T D LC +L +MNGGDL +H+
Sbjct: 224 KKRKGEAMALNEKRILEKVQSR----FIVSLAYAYETKDALCLVLTIMNGGDLKFHIYNL 279
Query: 135 GV--FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSK 192
G F+E FYAAE+ GLE + + IVYRDLKP NILLD+ GH+RISDLGLA + +
Sbjct: 280 GNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPE 339
Query: 193 -KKPHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDK-HEI 250
++ VGT GYMAPEV++ Y S DW+ GC++Y++++GHSPF+++K K K E+
Sbjct: 340 GQRVRGRVGTVGYMAPEVVN-NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEV 398
Query: 251 DKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCK 310
D+ ++N E FS KS+ LL ++ +KRLGC+
Sbjct: 399 DQ----RIKNDTEEYS------------------EKFSEDAKSICRMLLTKNPSKRLGCR 436
Query: 311 GRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTE 370
G GA VK+H F I+++++ PP P V D DI F KGI L
Sbjct: 437 GEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSA--VKGIYLDT 494
Query: 371 TDQMQYKDFPL-VISERWQAEVAET-VFDTVN 400
D+ Y F +S WQ E+ E+ F +N
Sbjct: 495 ADEDFYARFATGCVSIPWQNEMIESGCFKDIN 526
>X97881-1|CAA66470.1| 578|Homo sapiens G-protein coupled receptor
kinase protein.
Length = 578
Score = 273 bits (669), Expect = 1e-72
Identities = 160/392 (40%), Positives = 224/392 (57%), Gaps = 36/392 (9%)
Query: 15 SDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 74
S +++F QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L KKRI
Sbjct: 165 SSYFSQFLQWKWLERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRI 223
Query: 75 KMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 134
K ++GE +ALNE+ +L V + F+V + YA+ T D LC +L +MNGGDL +H+
Sbjct: 224 KKRKGEAMALNEKRILEKVQSR----FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNL 279
Query: 135 GV--FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSK 192
G F+E FYAAE+ GLE + + IVYRDLKP NILLD+ GH+RISDLGLA + +
Sbjct: 280 GNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPE 339
Query: 193 -KKPHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDK-HEI 250
++ VGT GYMAPEV++ Y S DW+ GC++Y++++GHSPF+++K K K E+
Sbjct: 340 GQRVRGRVGTVGYMAPEVVN-NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEV 398
Query: 251 DKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCK 310
D+ ++N E FS KS+ LL ++ +KRLGC+
Sbjct: 399 DQ----RIKNDTEEYS------------------EKFSEDAKSICRMLLTKNPSKRLGCR 436
Query: 311 GRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTE 370
G GA VK+H F I+++++ PP P V D DI F KGI L
Sbjct: 437 GEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSA--VKGIYLDT 494
Query: 371 TDQMQYKDFPL-VISERWQAEVAET-VFDTVN 400
D+ Y F +S WQ E+ E+ F +N
Sbjct: 495 ADEDFYARFATGCVSIPWQNEMIESGCFKDIN 526
>X97880-1|CAA66469.1| 546|Homo sapiens G-protein coupled receptor
kinase protein.
Length = 546
Score = 273 bits (669), Expect = 1e-72
Identities = 160/392 (40%), Positives = 224/392 (57%), Gaps = 36/392 (9%)
Query: 15 SDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 74
S +++F QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L KKRI
Sbjct: 133 SSYFSQFLQWKWLERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRI 191
Query: 75 KMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 134
K ++GE +ALNE+ +L V + F+V + YA+ T D LC +L +MNGGDL +H+
Sbjct: 192 KKRKGEAMALNEKRILEKVQSR----FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNL 247
Query: 135 GV--FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSK 192
G F+E FYAAE+ GLE + + IVYRDLKP NILLD+ GH+RISDLGLA + +
Sbjct: 248 GNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPE 307
Query: 193 -KKPHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDK-HEI 250
++ VGT GYMAPEV++ Y S DW+ GC++Y++++GHSPF+++K K K E+
Sbjct: 308 GQRVRGRVGTVGYMAPEVVN-NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEV 366
Query: 251 DKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCK 310
D+ ++N E FS KS+ LL ++ +KRLGC+
Sbjct: 367 DQ----RIKNDTEEYS------------------EKFSEDAKSICRMLLTKNPSKRLGCR 404
Query: 311 GRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTE 370
G GA VK+H F I+++++ PP P V D DI F KGI L
Sbjct: 405 GEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSA--VKGIYLDT 462
Query: 371 TDQMQYKDFPL-VISERWQAEVAET-VFDTVN 400
D+ Y F +S WQ E+ E+ F +N
Sbjct: 463 ADEDFYARFATGCVSIPWQNEMIESGCFKDIN 494
>U33055-1|AAC50407.1| 546|Homo sapiens G protein-coupled receptor
kinase GRK4, beta splice variant protein.
Length = 546
Score = 273 bits (669), Expect = 1e-72
Identities = 160/392 (40%), Positives = 224/392 (57%), Gaps = 36/392 (9%)
Query: 15 SDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 74
S +++F QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L KKRI
Sbjct: 133 SSYFSQFLQWKWLERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRI 191
Query: 75 KMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 134
K ++GE +ALNE+ +L V + F+V + YA+ T D LC +L +MNGGDL +H+
Sbjct: 192 KKRKGEAMALNEKRILEKVQSR----FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNL 247
Query: 135 GV--FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSK 192
G F+E FYAAE+ GLE + + IVYRDLKP NILLD+ GH+RISDLGLA + +
Sbjct: 248 GNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPE 307
Query: 193 -KKPHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDK-HEI 250
++ VGT GYMAPEV++ Y S DW+ GC++Y++++GHSPF+++K K K E+
Sbjct: 308 GQRVRGRVGTVGYMAPEVVN-NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEV 366
Query: 251 DKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCK 310
D+ ++N E FS KS+ LL ++ +KRLGC+
Sbjct: 367 DQ----RIKNDTEEYS------------------EKFSEDAKSICRMLLTKNPSKRLGCR 404
Query: 311 GRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTE 370
G GA VK+H F I+++++ PP P V D DI F KGI L
Sbjct: 405 GEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSA--VKGIYLDT 462
Query: 371 TDQMQYKDFPL-VISERWQAEVAET-VFDTVN 400
D+ Y F +S WQ E+ E+ F +N
Sbjct: 463 ADEDFYARFATGCVSIPWQNEMIESGCFKDIN 494
>U33054-1|AAC50406.1| 578|Homo sapiens G protein-coupled receptor
kinase GRK4, alpha splice variant protein.
Length = 578
Score = 273 bits (669), Expect = 1e-72
Identities = 160/392 (40%), Positives = 224/392 (57%), Gaps = 36/392 (9%)
Query: 15 SDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 74
S +++F QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L KKRI
Sbjct: 165 SSYFSQFLQWKWLERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRI 223
Query: 75 KMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 134
K ++GE +ALNE+ +L V + F+V + YA+ T D LC +L +MNGGDL +H+
Sbjct: 224 KKRKGEAMALNEKRILEKVQSR----FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNL 279
Query: 135 GV--FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSK 192
G F+E FYAAE+ GLE + + IVYRDLKP NILLD+ GH+RISDLGLA + +
Sbjct: 280 GNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPE 339
Query: 193 -KKPHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDK-HEI 250
++ VGT GYMAPEV++ Y S DW+ GC++Y++++GHSPF+++K K K E+
Sbjct: 340 GQRVRGRVGTVGYMAPEVVN-NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEV 398
Query: 251 DKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCK 310
D+ ++N E FS KS+ LL ++ +KRLGC+
Sbjct: 399 DQ----RIKNDTEEYS------------------EKFSEDAKSICRMLLTKNPSKRLGCR 436
Query: 311 GRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTE 370
G GA VK+H F I+++++ PP P V D DI F KGI L
Sbjct: 437 GEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSA--VKGIYLDT 494
Query: 371 TDQMQYKDFPL-VISERWQAEVAET-VFDTVN 400
D+ Y F +S WQ E+ E+ F +N
Sbjct: 495 ADEDFYARFATGCVSIPWQNEMIESGCFKDIN 526
>BC117320-1|AAI17321.1| 578|Homo sapiens G protein-coupled receptor
kinase 4 protein.
Length = 578
Score = 273 bits (669), Expect = 1e-72
Identities = 160/392 (40%), Positives = 224/392 (57%), Gaps = 36/392 (9%)
Query: 15 SDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 74
S +++F QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L KKRI
Sbjct: 165 SSYFSQFLQWKWLERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRI 223
Query: 75 KMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 134
K ++GE +ALNE+ +L V + F+V + YA+ T D LC +L +MNGGDL +H+
Sbjct: 224 KKRKGEAMALNEKRILEKVQSR----FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNL 279
Query: 135 GV--FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSK 192
G F+E FYAAE+ GLE + + IVYRDLKP NILLD+ GH+RISDLGLA + +
Sbjct: 280 GNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPE 339
Query: 193 -KKPHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDK-HEI 250
++ VGT GYMAPEV++ Y S DW+ GC++Y++++GHSPF+++K K K E+
Sbjct: 340 GQRVRGRVGTVGYMAPEVVN-NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEV 398
Query: 251 DKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCK 310
D+ ++N E FS KS+ LL ++ +KRLGC+
Sbjct: 399 DQ----RIKNDTEEYS------------------EKFSEDAKSICRMLLTKNPSKRLGCR 436
Query: 311 GRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTE 370
G GA VK+H F I+++++ PP P V D DI F KGI L
Sbjct: 437 GEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSA--VKGIYLDT 494
Query: 371 TDQMQYKDFPL-VISERWQAEVAET-VFDTVN 400
D+ Y F +S WQ E+ E+ F +N
Sbjct: 495 ADEDFYARFATGCVSIPWQNEMIESGCFKDIN 526
>U33168-4|AAC50412.1| 500|Homo sapiens G protein-coupled receptor
kinase GRK4-delta protein.
Length = 500
Score = 270 bits (663), Expect = 7e-72
Identities = 158/381 (41%), Positives = 218/381 (57%), Gaps = 35/381 (9%)
Query: 15 SDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 74
S +++F QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L KKRI
Sbjct: 133 SSYFSQFLQWKWLERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRI 191
Query: 75 KMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 134
K ++GE +ALNE+ +L V + FIV + YA+ T D LC +L +MNGGDL +H+
Sbjct: 192 KKRKGEAMALNEKRILEKVQSR----FIVSLAYAYETKDALCLVLTIMNGGDLKFHIYNL 247
Query: 135 GV--FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSK 192
G F+E FYAAE+ GLE + + IVYRDLKP NILLD+ GH+RISDLGLA + +
Sbjct: 248 GNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPE 307
Query: 193 -KKPHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDK-HEI 250
++ VGT GYMAPEV++ Y S DW+ GC++Y++++GHSPF+++K K K E+
Sbjct: 308 GQRVRGRVGTVGYMAPEVVN-NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEV 366
Query: 251 DKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCK 310
D+ ++N E FS KS+ LL ++ +KRLGC+
Sbjct: 367 DQ----RIKNDTEEYS------------------EKFSEDAKSICRMLLTKNPSKRLGCR 404
Query: 311 GRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTE 370
G GA VK+H F I+++++ PP P V D DI F KGI L
Sbjct: 405 GEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSA--VKGIYLDT 462
Query: 371 TDQMQYKDFPL-VISERWQAE 390
D+ Y F +S WQ E
Sbjct: 463 ADEDFYARFATGCVSIPWQNE 483
>U33168-2|AAC50411.1| 532|Homo sapiens G protein-coupled receptor
kinase GRK4-gamma protein.
Length = 532
Score = 270 bits (663), Expect = 7e-72
Identities = 158/381 (41%), Positives = 218/381 (57%), Gaps = 35/381 (9%)
Query: 15 SDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 74
S +++F QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L KKRI
Sbjct: 165 SSYFSQFLQWKWLERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRI 223
Query: 75 KMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 134
K ++GE +ALNE+ +L V + FIV + YA+ T D LC +L +MNGGDL +H+
Sbjct: 224 KKRKGEAMALNEKRILEKVQSR----FIVSLAYAYETKDALCLVLTIMNGGDLKFHIYNL 279
Query: 135 GV--FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSK 192
G F+E FYAAE+ GLE + + IVYRDLKP NILLD+ GH+RISDLGLA + +
Sbjct: 280 GNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPE 339
Query: 193 -KKPHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDK-HEI 250
++ VGT GYMAPEV++ Y S DW+ GC++Y++++GHSPF+++K K K E+
Sbjct: 340 GQRVRGRVGTVGYMAPEVVN-NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEV 398
Query: 251 DKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCK 310
D+ ++N E FS KS+ LL ++ +KRLGC+
Sbjct: 399 DQ----RIKNDTEEYS------------------EKFSEDAKSICRMLLTKNPSKRLGCR 436
Query: 311 GRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTE 370
G GA VK+H F I+++++ PP P V D DI F KGI L
Sbjct: 437 GEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSA--VKGIYLDT 494
Query: 371 TDQMQYKDFPL-VISERWQAE 390
D+ Y F +S WQ E
Sbjct: 495 ADEDFYARFATGCVSIPWQNE 515
>X98118-1|CAA66802.1| 532|Homo sapiens G protein-coupled receptor
kinase protein.
Length = 532
Score = 270 bits (662), Expect = 9e-72
Identities = 157/381 (41%), Positives = 218/381 (57%), Gaps = 35/381 (9%)
Query: 15 SDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 74
S +++F QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L KKRI
Sbjct: 165 SSYFSQFLQWKWLERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRI 223
Query: 75 KMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 134
K ++GE +ALNE+ +L V + F+V + YA+ T D LC +L +MNGGDL +H+
Sbjct: 224 KKRKGEAMALNEKRILEKVQSR----FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNL 279
Query: 135 GV--FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSK 192
G F+E FYAAE+ GLE + + IVYRDLKP NILLD+ GH+RISDLGLA + +
Sbjct: 280 GNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPE 339
Query: 193 -KKPHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDK-HEI 250
++ VGT GYMAPEV++ Y S DW+ GC++Y++++GHSPF+++K K K E+
Sbjct: 340 GQRVRGRVGTVGYMAPEVVN-NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEV 398
Query: 251 DKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCK 310
D+ ++N E FS KS+ LL ++ +KRLGC+
Sbjct: 399 DQ----RIKNDTEEYS------------------EKFSEDAKSICRMLLTKNPSKRLGCR 436
Query: 311 GRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTE 370
G GA VK+H F I+++++ PP P V D DI F KGI L
Sbjct: 437 GEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSA--VKGIYLDT 494
Query: 371 TDQMQYKDFPL-VISERWQAE 390
D+ Y F +S WQ E
Sbjct: 495 ADEDFYARFATGCVSIPWQNE 515
>X97879-1|CAA66468.1| 500|Homo sapiens G-protein coupled receptor
kinase protein.
Length = 500
Score = 270 bits (662), Expect = 9e-72
Identities = 157/381 (41%), Positives = 218/381 (57%), Gaps = 35/381 (9%)
Query: 15 SDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 74
S +++F QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L KKRI
Sbjct: 133 SSYFSQFLQWKWLERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRI 191
Query: 75 KMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 134
K ++GE +ALNE+ +L V + F+V + YA+ T D LC +L +MNGGDL +H+
Sbjct: 192 KKRKGEAMALNEKRILEKVQSR----FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNL 247
Query: 135 GV--FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSK 192
G F+E FYAAE+ GLE + + IVYRDLKP NILLD+ GH+RISDLGLA + +
Sbjct: 248 GNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPE 307
Query: 193 -KKPHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDK-HEI 250
++ VGT GYMAPEV++ Y S DW+ GC++Y++++GHSPF+++K K K E+
Sbjct: 308 GQRVRGRVGTVGYMAPEVVN-NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEV 366
Query: 251 DKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCK 310
D+ ++N E FS KS+ LL ++ +KRLGC+
Sbjct: 367 DQ----RIKNDTEEYS------------------EKFSEDAKSICRMLLTKNPSKRLGCR 404
Query: 311 GRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTE 370
G GA VK+H F I+++++ PP P V D DI F KGI L
Sbjct: 405 GEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSA--VKGIYLDT 462
Query: 371 TDQMQYKDFPL-VISERWQAE 390
D+ Y F +S WQ E
Sbjct: 463 ADEDFYARFATGCVSIPWQNE 483
>U33056-1|AAC50408.1| 532|Homo sapiens G protein-coupled receptor
kinase GRK4, gamma splice variant protein.
Length = 532
Score = 270 bits (662), Expect = 9e-72
Identities = 157/381 (41%), Positives = 218/381 (57%), Gaps = 35/381 (9%)
Query: 15 SDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 74
S +++F QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L KKRI
Sbjct: 165 SSYFSQFLQWKWLERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRI 223
Query: 75 KMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 134
K ++GE +ALNE+ +L V + F+V + YA+ T D LC +L +MNGGDL +H+
Sbjct: 224 KKRKGEAMALNEKRILEKVQSR----FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNL 279
Query: 135 GV--FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSK 192
G F+E FYAAE+ GLE + + IVYRDLKP NILLD+ GH+RISDLGLA + +
Sbjct: 280 GNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPE 339
Query: 193 -KKPHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDK-HEI 250
++ VGT GYMAPEV++ Y S DW+ GC++Y++++GHSPF+++K K K E+
Sbjct: 340 GQRVRGRVGTVGYMAPEVVN-NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEV 398
Query: 251 DKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCK 310
D+ ++N E FS KS+ LL ++ +KRLGC+
Sbjct: 399 DQ----RIKNDTEEYS------------------EKFSEDAKSICRMLLTKNPSKRLGCR 436
Query: 311 GRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTE 370
G GA VK+H F I+++++ PP P V D DI F KGI L
Sbjct: 437 GEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSA--VKGIYLDT 494
Query: 371 TDQMQYKDFPL-VISERWQAE 390
D+ Y F +S WQ E
Sbjct: 495 ADEDFYARFATGCVSIPWQNE 515
>L03718-1|AAB04045.1| 500|Homo sapiens G protein-coupled receptor
protein.
Length = 500
Score = 270 bits (662), Expect = 9e-72
Identities = 157/381 (41%), Positives = 218/381 (57%), Gaps = 35/381 (9%)
Query: 15 SDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 74
S +++F QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L KKRI
Sbjct: 133 SSYFSQFLQWKWLERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRI 191
Query: 75 KMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 134
K ++GE +ALNE+ +L V + F+V + YA+ T D LC +L +MNGGDL +H+
Sbjct: 192 KKRKGEAMALNEKRILEKVQSR----FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNL 247
Query: 135 GV--FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSK 192
G F+E FYAAE+ GLE + + IVYRDLKP NILLD+ GH+RISDLGLA + +
Sbjct: 248 GNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPE 307
Query: 193 -KKPHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDK-HEI 250
++ VGT GYMAPEV++ Y S DW+ GC++Y++++GHSPF+++K K K E+
Sbjct: 308 GQRVRGRVGTVGYMAPEVVN-NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEV 366
Query: 251 DKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCK 310
D+ ++N E FS KS+ LL ++ +KRLGC+
Sbjct: 367 DQ----RIKNDTEEYS------------------EKFSEDAKSICRMLLTKNPSKRLGCR 404
Query: 311 GRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTE 370
G GA VK+H F I+++++ PP P V D DI F KGI L
Sbjct: 405 GEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSA--VKGIYLDT 462
Query: 371 TDQMQYKDFPL-VISERWQAE 390
D+ Y F +S WQ E
Sbjct: 463 ADEDFYARFATGCVSIPWQNE 483
>AK223581-1|BAD97301.1| 500|Homo sapiens G protein-coupled receptor
kinase 2-like isoform 2 variant protein.
Length = 500
Score = 270 bits (661), Expect = 1e-71
Identities = 157/381 (41%), Positives = 218/381 (57%), Gaps = 35/381 (9%)
Query: 15 SDKYTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI 74
S +++F QWK LE +T N F +R++G+GGFGEV C+ TGKMYA K L KKRI
Sbjct: 133 SSYFSQFLQWKWLERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRI 191
Query: 75 KMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH 134
K ++GE +ALNE+ +L V + F+V + YA+ T D LC +L +MNGGDL +H+
Sbjct: 192 KKRKGEAMALNEKRILEKVQSR----FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNL 247
Query: 135 GV--FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSK 192
G F+E FYAAE+ GLE + + IVYRDLKP NILLD+ GH+RISDLGLA + +
Sbjct: 248 GNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPE 307
Query: 193 -KKPHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDK-HEI 250
++ VGT GYMAPEV++ Y S DW+ GC++Y++++GHSPF+++K K K E+
Sbjct: 308 GQRVRGRVGTVGYMAPEVVN-NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEV 366
Query: 251 DKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCK 310
D+ ++N E FS KS+ LL ++ +KRLGC+
Sbjct: 367 DQ----RIKNDTEEYS------------------EKFSEDAKSICRMLLTKNPSKRLGCR 404
Query: 311 GRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTE 370
G GA VK+H F I+++++ PP P V D DI F KGI L
Sbjct: 405 GEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSV--VKGIYLDT 462
Query: 371 TDQMQYKDFPL-VISERWQAE 390
D+ Y F +S WQ E
Sbjct: 463 ADEDFYARFATGCVSIPWQNE 483
>AF439409-1|AAL48216.1| 553|Homo sapiens G-protein-coupled receptor
kinase 7 protein.
Length = 553
Score = 242 bits (593), Expect = 2e-63
Identities = 138/388 (35%), Positives = 218/388 (56%), Gaps = 33/388 (8%)
Query: 18 YTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK 77
Y +F QWK E+ ++ F+ R++G+GGFGEV + +TGKMYA K LDKKR+K K
Sbjct: 172 YDKFLQWKLFEMQ-PVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKK 230
Query: 78 QGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV- 136
GE +AL E+ +L VS+ PFIV + YAF + LC ++ LMNGGDL +H+ G
Sbjct: 231 GGEKMALLEKEILEKVSS----PFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTR 286
Query: 137 -FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP 195
+ + + FY+A++ G+ H+H+ IVYRD+KP N+LLD+ G+ R+SDLGLA + KP
Sbjct: 287 GLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKP 346
Query: 196 HAS-VGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMT 254
GT+GYMAPE+L + Y DWF+ GC +Y+++ G +PF+ +K K + K
Sbjct: 347 ITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEK----VSKED 402
Query: 255 LTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGA 314
L TL + + ++F+ K + L + +RLG + + +
Sbjct: 403 L----------------KQRTLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSREK-S 445
Query: 315 DEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQM 374
D+ ++H FF I++ ++ PP +P V A D +I F E +G++ + D+
Sbjct: 446 DDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIAEIDDFSE--VRGVEFDDKDKQ 503
Query: 375 QYKDFPL-VISERWQAEVAET-VFDTVN 400
+K+F + WQ E+ ET +F+ +N
Sbjct: 504 FFKNFATGAVPIAWQEEIIETGLFEELN 531
>AF282269-1|AAL33880.1| 553|Homo sapiens G protein-coupled receptor
kinase 7 protein.
Length = 553
Score = 242 bits (593), Expect = 2e-63
Identities = 138/388 (35%), Positives = 218/388 (56%), Gaps = 33/388 (8%)
Query: 18 YTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK 77
Y +F QWK E+ ++ F+ R++G+GGFGEV + +TGKMYA K LDKKR+K K
Sbjct: 172 YDKFLQWKLFEMQ-PVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKK 230
Query: 78 QGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV- 136
GE +AL E+ +L VS+ PFIV + YAF + LC ++ LMNGGDL +H+ G
Sbjct: 231 GGEKMALLEKEILEKVSS----PFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTR 286
Query: 137 -FNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP 195
+ + + FY+A++ G+ H+H+ IVYRD+KP N+LLD+ G+ R+SDLGLA + KP
Sbjct: 287 GLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKP 346
Query: 196 HAS-VGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMT 254
GT+GYMAPE+L + Y DWF+ GC +Y+++ G +PF+ +K K + K
Sbjct: 347 ITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEK----VSKED 402
Query: 255 LTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGA 314
L TL + + ++F+ K + L + +RLG + + +
Sbjct: 403 L----------------KQRTLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSREK-S 445
Query: 315 DEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQM 374
D+ ++H FF I++ ++ PP +P V A D +I F E +G++ + D+
Sbjct: 446 DDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIAEIDDFSE--VRGVEFDDKDKQ 503
Query: 375 QYKDFPL-VISERWQAEVAET-VFDTVN 400
+K+F + WQ E+ ET +F+ +N
Sbjct: 504 FFKNFATGAVPIAWQEEIIETGLFEELN 531
>U63973-1|AAB05929.1| 563|Homo sapiens rhodopsin kinase protein.
Length = 563
Score = 241 bits (589), Expect = 6e-63
Identities = 146/392 (37%), Positives = 215/392 (54%), Gaps = 37/392 (9%)
Query: 18 YTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK 77
+ RF QWK LE + + F R++G+GGFGEV C+ TGK+YA K L+KKR+K +
Sbjct: 171 FLRFLQWKWLEAQ-PMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKR 229
Query: 78 QGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHL----SQ 133
+G A+ E+ +L V + FIV + YAF T LC ++ +MNGGD+ YH+ +
Sbjct: 230 KGYQGAMVEKKILMKVHSR----FIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEE 285
Query: 134 HGVFNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--S 191
+ F E FY A++I GLEH+H+R IVYRDLKP N+LLD G+VRISDLGLA +
Sbjct: 286 NPGFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDG 345
Query: 192 KKKPHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEID 251
+ K GT G+MAPE+L +G YD S D+F+ G LY+++ PFR K +++
Sbjct: 346 QSKTKGYAGTPGFMAPELL-QGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKEL 404
Query: 252 KMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKG 311
K + + E + P+ FS + K E LL++D KRLG +
Sbjct: 405 KHRI--------------------ISEPVK-YPDKFSQASKDFCEALLEKDPEKRLGFRD 443
Query: 312 RGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTET 371
D+++ H F ++W+Q+ PP IP V A D D+G+F KG+ +T
Sbjct: 444 ETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVYAKDIQDVGAF--STVKGVAFDKT 501
Query: 372 DQMQYKDFPL-VISERWQAEVAET-VFDTVNL 401
D +++F WQ E+ ET +F +N+
Sbjct: 502 DTEFFQEFATGNCPIPWQEEMIETGIFGELNV 533
>L77503-1|AAG50439.1| 563|Homo sapiens rhodopsin kinase protein.
Length = 563
Score = 241 bits (589), Expect = 6e-63
Identities = 146/392 (37%), Positives = 215/392 (54%), Gaps = 37/392 (9%)
Query: 18 YTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK 77
+ RF QWK LE + + F R++G+GGFGEV C+ TGK+YA K L+KKR+K +
Sbjct: 171 FLRFLQWKWLEAQ-PMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKR 229
Query: 78 QGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHL----SQ 133
+G A+ E+ +L V + FIV + YAF T LC ++ +MNGGD+ YH+ +
Sbjct: 230 KGYQGAMVEKKILMKVHSR----FIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEE 285
Query: 134 HGVFNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--S 191
+ F E FY A++I GLEH+H+R IVYRDLKP N+LLD G+VRISDLGLA +
Sbjct: 286 NPGFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDG 345
Query: 192 KKKPHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEID 251
+ K GT G+MAPE+L +G YD S D+F+ G LY+++ PFR K +++
Sbjct: 346 QSKTKGYAGTPGFMAPELL-QGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKEL 404
Query: 252 KMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKG 311
K + + E + P+ FS + K E LL++D KRLG +
Sbjct: 405 KHRI--------------------ISEPVK-YPDKFSQASKDFCEALLEKDPEKRLGFRD 443
Query: 312 RGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTET 371
D+++ H F ++W+Q+ PP IP V A D D+G+F KG+ +T
Sbjct: 444 ETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVYAKDIQDVGAF--STVKGVAFDKT 501
Query: 372 DQMQYKDFPL-VISERWQAEVAET-VFDTVNL 401
D +++F WQ E+ ET +F +N+
Sbjct: 502 DTEFFQEFATGNCPIPWQEEMIETGIFGELNV 533
>L77502-1|AAT00534.2| 563|Homo sapiens rhodopsin kinase protein.
Length = 563
Score = 241 bits (589), Expect = 6e-63
Identities = 146/392 (37%), Positives = 215/392 (54%), Gaps = 37/392 (9%)
Query: 18 YTRFCQWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK 77
+ RF QWK LE + + F R++G+GGFGEV C+ TGK+YA K L+KKR+K +
Sbjct: 171 FLRFLQWKWLEAQ-PMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKR 229
Query: 78 QGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHL----SQ 133
+G A+ E+ +L V + FIV + YAF T LC ++ +MNGGD+ YH+ +
Sbjct: 230 KGYQGAMVEKKILMKVHSR----FIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEE 285
Query: 134 HGVFNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--S 191
+ F E FY A++I GLEH+H+R IVYRDLKP N+LLD G+VRISDLGLA +
Sbjct: 286 NPGFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDG 345
Query: 192 KKKPHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEID 251
+ K GT G+MAPE+L +G YD S D+F+ G LY+++ PFR K +++
Sbjct: 346 QSKTKGYAGTPGFMAPELL-QGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKEL 404
Query: 252 KMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKG 311
K + + E + P+ FS + K E LL++D KRLG +
Sbjct: 405 KHRI--------------------ISEPVK-YPDKFSQASKDFCEALLEKDPEKRLGFRD 443
Query: 312 RGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTET 371
D+++ H F ++W+Q+ PP IP V A D D+G+F KG+ +T
Sbjct: 444 ETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVYAKDIQDVGAF--STVKGVAFDKT 501
Query: 372 DQMQYKDFPL-VISERWQAEVAET-VFDTVNL 401
D +++F WQ E+ ET +F +N+
Sbjct: 502 DTEFFQEFATGNCPIPWQEEMIETGIFGELNV 533
>L07597-1|AAC82497.1| 735|Homo sapiens ribosomal protein S6 kinase
1 protein.
Length = 735
Score = 215 bits (525), Expect = 3e-55
Identities = 127/352 (36%), Positives = 199/352 (56%), Gaps = 38/352 (10%)
Query: 38 FSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 94
F + +++G+G FG+V+ RK D+G +YAMK L K +K++ + I+
Sbjct: 62 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILAD--- 118
Query: 95 TGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLE 154
V+ PF+V + YAF T KL ILD + GGDL LS+ +F E ++KFY AE+ LGL+
Sbjct: 119 --VNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLD 176
Query: 155 HMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLSK 212
H+H I+YRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+++
Sbjct: 177 HLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNR 236
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXA 272
G+ SADW+S+G +++++L G PF + KD+ E T+T++
Sbjct: 237 -QGHSHSADWWSYGVLMFEMLTGSLPF---QGKDRKE----TMTLILKA----------- 277
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+ G+P+ S +SLL L +R+ RLG GA+E+K HVF++ IDW ++Y
Sbjct: 278 -------KLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLY 330
Query: 333 HQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTETDQMQYKDFPLV 382
++ TPP P + + FD S +D+ GI + ++ F V
Sbjct: 331 RREITPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFV 382
Score = 89.0 bits (211), Expect = 4e-17
Identities = 67/219 (30%), Positives = 104/219 (47%), Gaps = 17/219 (7%)
Query: 38 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGV 97
+ V IG G + E C T YA+K +DK K E + + L+ G
Sbjct: 418 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKS--KRDPSEEIEI-------LLRYGQ 468
Query: 98 DCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHMH 157
P I+ + + + + +LM GG+L + + F+E E F + +E++H
Sbjct: 469 H-PNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLH 527
Query: 158 KRHIVYRDLKPANIL-LDEHGH---VRISDLGLACDFSKKKP--HASVGTHGYMAPEVLS 211
+ +V+RDLKP+NIL +DE G+ +RI D G A + T ++APEVL
Sbjct: 528 SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL- 586
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEI 250
K GYD D +S G +LY +L G++PF + EI
Sbjct: 587 KRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEI 625
>BC014966-1|AAH14966.1| 735|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 1 protein.
Length = 735
Score = 213 bits (519), Expect = 2e-54
Identities = 126/352 (35%), Positives = 198/352 (56%), Gaps = 38/352 (10%)
Query: 38 FSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 94
F + +++G+G FG+V+ RK D+G +YAMK L K +K++ + I+
Sbjct: 62 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILAD--- 118
Query: 95 TGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLE 154
V+ PF+V + YAF T KL ILD + GGDL LS+ +F E ++KFY AE+ LGL+
Sbjct: 119 --VNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLD 176
Query: 155 HMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLSK 212
H+H I+YRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+++
Sbjct: 177 HLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNR 236
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXA 272
G+ SADW+S+G +++++L G PF + KD+ E T+T++
Sbjct: 237 -QGHSHSADWWSYGVLMFEMLTGSLPF---QGKDRKE----TMTLILKA----------- 277
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+ G+P+ S +SLL L +R+ RLG GA+E+K HVF++ IDW ++Y
Sbjct: 278 -------KLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLY 330
Query: 333 HQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTETDQMQYKDFPLV 382
++ PP P + + FD S +D+ GI + ++ F V
Sbjct: 331 RREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFV 382
Score = 89.0 bits (211), Expect = 4e-17
Identities = 67/219 (30%), Positives = 104/219 (47%), Gaps = 17/219 (7%)
Query: 38 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGV 97
+ V IG G + E C T YA+K +DK K E + + L+ G
Sbjct: 418 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKS--KRDPSEEIEI-------LLRYGQ 468
Query: 98 DCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHMH 157
P I+ + + + + +LM GG+L + + F+E E F + +E++H
Sbjct: 469 H-PNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLH 527
Query: 158 KRHIVYRDLKPANIL-LDEHGH---VRISDLGLACDFSKKKP--HASVGTHGYMAPEVLS 211
+ +V+RDLKP+NIL +DE G+ +RI D G A + T ++APEVL
Sbjct: 528 SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL- 586
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEI 250
K GYD D +S G +LY +L G++PF + EI
Sbjct: 587 KRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEI 625
>AL627313-6|CAI14649.1| 735|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 1 protein.
Length = 735
Score = 213 bits (519), Expect = 2e-54
Identities = 126/352 (35%), Positives = 198/352 (56%), Gaps = 38/352 (10%)
Query: 38 FSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 94
F + +++G+G FG+V+ RK D+G +YAMK L K +K++ + I+
Sbjct: 62 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILAD--- 118
Query: 95 TGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLE 154
V+ PF+V + YAF T KL ILD + GGDL LS+ +F E ++KFY AE+ LGL+
Sbjct: 119 --VNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLD 176
Query: 155 HMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLSK 212
H+H I+YRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+++
Sbjct: 177 HLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNR 236
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXA 272
G+ SADW+S+G +++++L G PF + KD+ E T+T++
Sbjct: 237 -QGHSHSADWWSYGVLMFEMLTGSLPF---QGKDRKE----TMTLILKA----------- 277
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+ G+P+ S +SLL L +R+ RLG GA+E+K HVF++ IDW ++Y
Sbjct: 278 -------KLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLY 330
Query: 333 HQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTETDQMQYKDFPLV 382
++ PP P + + FD S +D+ GI + ++ F V
Sbjct: 331 RREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFV 382
Score = 89.0 bits (211), Expect = 4e-17
Identities = 67/219 (30%), Positives = 104/219 (47%), Gaps = 17/219 (7%)
Query: 38 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGV 97
+ V IG G + E C T YA+K +DK K E + + L+ G
Sbjct: 418 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKS--KRDPSEEIEI-------LLRYGQ 468
Query: 98 DCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHMH 157
P I+ + + + + +LM GG+L + + F+E E F + +E++H
Sbjct: 469 H-PNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLH 527
Query: 158 KRHIVYRDLKPANIL-LDEHGH---VRISDLGLACDFSKKKP--HASVGTHGYMAPEVLS 211
+ +V+RDLKP+NIL +DE G+ +RI D G A + T ++APEVL
Sbjct: 528 SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL- 586
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEI 250
K GYD D +S G +LY +L G++PF + EI
Sbjct: 587 KRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEI 625
>U08316-1|AAA81952.1| 740|Homo sapiens insulin-stimulated protein
kinase 1 protein.
Length = 740
Score = 212 bits (518), Expect = 2e-54
Identities = 129/368 (35%), Positives = 205/368 (55%), Gaps = 39/368 (10%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
+ F + +++G+G FG+V+ +K +D ++YAMK L K +K++ + I++
Sbjct: 66 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVE- 124
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
V+ PFIV + YAF T KL ILD + GGDL LS+ +F E ++KFY AE+ L
Sbjct: 125 ----VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVL 210
L+H+H I+YRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+
Sbjct: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 240
Query: 211 SKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXX 270
++ G+ SADW+SFG +++++L G PF + KD+ E T+TM+
Sbjct: 241 NR-RGHTQSADWWSFGVLMFEMLTGTLPF---QGKDRKE----TMTMILKA--------- 283
Query: 271 XASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQ 330
+ G+P+ SP +SLL L +R+ RLG G +E+K H FF+ IDW +
Sbjct: 284 ---------KLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNK 334
Query: 331 VYHQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTETDQMQYKDFPLV-ISERW 387
+Y ++ PP P G FD + +D+ GI + ++ F V I+
Sbjct: 335 LYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDD 394
Query: 388 QAEVAETV 395
+++ +TV
Sbjct: 395 ESQAMQTV 402
Score = 83.8 bits (198), Expect = 1e-15
Identities = 69/227 (30%), Positives = 110/227 (48%), Gaps = 18/227 (7%)
Query: 30 NIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 89
+IQ T + + V IG G + C T +A+K +DK K+ T E I
Sbjct: 415 SIQFT-DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKS----KRDPT----EEIE 465
Query: 90 LSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEV 149
+ L+ G P I+ + + + + +LM GG+L + + F+E E +
Sbjct: 466 I-LLRYGQH-PNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTI 523
Query: 150 ILGLEHMHKRHIVYRDLKPANIL-LDEHGH---VRISDLGLACDFSKKKP--HASVGTHG 203
+E++H + +V+RDLKP+NIL +DE G+ +RI D G A + T
Sbjct: 524 TKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTAN 583
Query: 204 YMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEI 250
++APEVL K GYD++ D +S G +LY +L G++PF EI
Sbjct: 584 FVAPEVL-KRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEI 629
>L07599-1|AAC82495.1| 580|Homo sapiens ribosomal protein S6 kinase
3 protein.
Length = 580
Score = 212 bits (518), Expect = 2e-54
Identities = 129/368 (35%), Positives = 205/368 (55%), Gaps = 39/368 (10%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
+ F + +++G+G FG+V+ +K +D ++YAMK L K +K++ + I++
Sbjct: 65 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVE- 123
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
V+ PFIV + YAF T KL ILD + GGDL LS+ +F E ++KFY AE+ L
Sbjct: 124 ----VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 179
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVL 210
L+H+H I+YRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+
Sbjct: 180 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 239
Query: 211 SKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXX 270
++ G+ SADW+SFG +++++L G PF + KD+ E T+TM+
Sbjct: 240 NR-RGHTQSADWWSFGVLMFEMLTGTLPF---QGKDRKE----TMTMILKA--------- 282
Query: 271 XASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQ 330
+ G+P+ SP +SLL L +R+ RLG G +E+K H FF+ IDW +
Sbjct: 283 ---------KLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNK 333
Query: 331 VYHQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTETDQMQYKDFPLV-ISERW 387
+Y ++ PP P G FD + +D+ GI + ++ F V I+
Sbjct: 334 LYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDD 393
Query: 388 QAEVAETV 395
+++ +TV
Sbjct: 394 ESQAMQTV 401
Score = 54.8 bits (126), Expect = 8e-07
Identities = 48/162 (29%), Positives = 80/162 (49%), Gaps = 16/162 (9%)
Query: 30 NIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 89
+IQ T + + + IG G + C T +A+K +DK K+ T E I
Sbjct: 414 SIQFT-DGYELKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKS----KRDPT----EEIE 464
Query: 90 LSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEV 149
+ L+ G P I+ + + K +++ LM GG+L + + F+E E +
Sbjct: 465 I-LLRYGQH-PNIITLNDVYDD-GKYVYVVTLMKGGELLDKILRQKFFSEREASAVLFTI 521
Query: 150 ILGLEHMHKRHIVYRDLKPANIL-LDEHGH---VRISDLGLA 187
+E++H + +V+RDLKP+NIL +DE G+ +RI D G A
Sbjct: 522 TKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFA 563
>BC096303-1|AAH96303.1| 740|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 3 protein.
Length = 740
Score = 212 bits (518), Expect = 2e-54
Identities = 129/368 (35%), Positives = 205/368 (55%), Gaps = 39/368 (10%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
+ F + +++G+G FG+V+ +K +D ++YAMK L K +K++ + I++
Sbjct: 66 SQFELLKVLGQGSFGKVFLVKKILGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVE- 124
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
V+ PFIV + YAF T KL ILD + GGDL LS+ +F E ++KFY AE+ L
Sbjct: 125 ----VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVL 210
L+H+H I+YRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+
Sbjct: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 240
Query: 211 SKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXX 270
++ G+ SADW+SFG +++++L G PF + KD+ E T+TM+
Sbjct: 241 NR-RGHTQSADWWSFGVLMFEMLTGTLPF---QGKDRKE----TMTMILKA--------- 283
Query: 271 XASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQ 330
+ G+P+ SP +SLL L +R+ RLG G +E+K H FF+ IDW +
Sbjct: 284 ---------KLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNK 334
Query: 331 VYHQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTETDQMQYKDFPLV-ISERW 387
+Y ++ PP P G FD + +D+ GI + ++ F V I+
Sbjct: 335 LYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDD 394
Query: 388 QAEVAETV 395
+++ +TV
Sbjct: 395 ESQAMQTV 402
Score = 83.8 bits (198), Expect = 1e-15
Identities = 69/227 (30%), Positives = 110/227 (48%), Gaps = 18/227 (7%)
Query: 30 NIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 89
+IQ T + + V IG G + C T +A+K +DK K+ T E I
Sbjct: 415 SIQFT-DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKS----KRDPT----EEIE 465
Query: 90 LSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEV 149
+ L+ G P I+ + + + + +LM GG+L + + F+E E +
Sbjct: 466 I-LLRYGQH-PNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTI 523
Query: 150 ILGLEHMHKRHIVYRDLKPANIL-LDEHGH---VRISDLGLACDFSKKKP--HASVGTHG 203
+E++H + +V+RDLKP+NIL +DE G+ +RI D G A + T
Sbjct: 524 TKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTAN 583
Query: 204 YMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEI 250
++APEVL K GYD++ D +S G +LY +L G++PF EI
Sbjct: 584 FVAPEVL-KRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEI 629
>BC096302-1|AAH96302.1| 740|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 3 protein.
Length = 740
Score = 212 bits (518), Expect = 2e-54
Identities = 129/368 (35%), Positives = 205/368 (55%), Gaps = 39/368 (10%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
+ F + +++G+G FG+V+ +K +D ++YAMK L K +K++ + I++
Sbjct: 66 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVE- 124
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
V+ PFIV + YAF T KL ILD + GGDL LS+ +F E ++KFY AE+ L
Sbjct: 125 ----VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVL 210
L+H+H I+YRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+
Sbjct: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 240
Query: 211 SKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXX 270
++ G+ SADW+SFG +++++L G PF + KD+ E T+TM+
Sbjct: 241 NR-RGHTQSADWWSFGVLMFEMLTGTLPF---QGKDRKE----TMTMILKA--------- 283
Query: 271 XASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQ 330
+ G+P+ SP +SLL L +R+ RLG G +E+K H FF+ IDW +
Sbjct: 284 ---------KLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNK 334
Query: 331 VYHQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTETDQMQYKDFPLV-ISERW 387
+Y ++ PP P G FD + +D+ GI + ++ F V I+
Sbjct: 335 LYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDD 394
Query: 388 QAEVAETV 395
+++ +TV
Sbjct: 395 ESQAMQTV 402
Score = 83.8 bits (198), Expect = 1e-15
Identities = 69/227 (30%), Positives = 110/227 (48%), Gaps = 18/227 (7%)
Query: 30 NIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 89
+IQ T + + V IG G + C T +A+K +DK K+ T E I
Sbjct: 415 SIQFT-DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKS----KRDPT----EEIE 465
Query: 90 LSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEV 149
+ L+ G P I+ + + + + +LM GG+L + + F+E E +
Sbjct: 466 I-LLRYGQH-PNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTI 523
Query: 150 ILGLEHMHKRHIVYRDLKPANIL-LDEHGH---VRISDLGLACDFSKKKP--HASVGTHG 203
+E++H + +V+RDLKP+NIL +DE G+ +RI D G A + T
Sbjct: 524 TKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTAN 583
Query: 204 YMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEI 250
++APEVL K GYD++ D +S G +LY +L G++PF EI
Sbjct: 584 FVAPEVL-KRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEI 629
>BC096301-1|AAH96301.1| 740|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 3 protein.
Length = 740
Score = 212 bits (518), Expect = 2e-54
Identities = 129/368 (35%), Positives = 205/368 (55%), Gaps = 39/368 (10%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
+ F + +++G+G FG+V+ +K +D ++YAMK L K +K++ + I++
Sbjct: 66 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVE- 124
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
V+ PFIV + YAF T KL ILD + GGDL LS+ +F E ++KFY AE+ L
Sbjct: 125 ----VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVL 210
L+H+H I+YRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+
Sbjct: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 240
Query: 211 SKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXX 270
++ G+ SADW+SFG +++++L G PF + KD+ E T+TM+
Sbjct: 241 NR-RGHTQSADWWSFGVLMFEMLTGTLPF---QGKDRKE----TMTMILKA--------- 283
Query: 271 XASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQ 330
+ G+P+ SP +SLL L +R+ RLG G +E+K H FF+ IDW +
Sbjct: 284 ---------KLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNK 334
Query: 331 VYHQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTETDQMQYKDFPLV-ISERW 387
+Y ++ PP P G FD + +D+ GI + ++ F V I+
Sbjct: 335 LYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDD 394
Query: 388 QAEVAETV 395
+++ +TV
Sbjct: 395 ESQAMQTV 402
Score = 83.8 bits (198), Expect = 1e-15
Identities = 69/227 (30%), Positives = 110/227 (48%), Gaps = 18/227 (7%)
Query: 30 NIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 89
+IQ T + + V IG G + C T +A+K +DK K+ T E I
Sbjct: 415 SIQFT-DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKS----KRDPT----EEIE 465
Query: 90 LSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEV 149
+ L+ G P I+ + + + + +LM GG+L + + F+E E +
Sbjct: 466 I-LLRYGQH-PNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTI 523
Query: 150 ILGLEHMHKRHIVYRDLKPANIL-LDEHGH---VRISDLGLACDFSKKKP--HASVGTHG 203
+E++H + +V+RDLKP+NIL +DE G+ +RI D G A + T
Sbjct: 524 TKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTAN 583
Query: 204 YMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEI 250
++APEVL K GYD++ D +S G +LY +L G++PF EI
Sbjct: 584 FVAPEVL-KRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEI 629
>AL807772-3|CAI39687.1| 740|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 3 protein.
Length = 740
Score = 212 bits (518), Expect = 2e-54
Identities = 129/368 (35%), Positives = 205/368 (55%), Gaps = 39/368 (10%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
+ F + +++G+G FG+V+ +K +D ++YAMK L K +K++ + I++
Sbjct: 66 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVE- 124
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
V+ PFIV + YAF T KL ILD + GGDL LS+ +F E ++KFY AE+ L
Sbjct: 125 ----VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVL 210
L+H+H I+YRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+
Sbjct: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 240
Query: 211 SKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXX 270
++ G+ SADW+SFG +++++L G PF + KD+ E T+TM+
Sbjct: 241 NR-RGHTQSADWWSFGVLMFEMLTGTLPF---QGKDRKE----TMTMILKA--------- 283
Query: 271 XASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQ 330
+ G+P+ SP +SLL L +R+ RLG G +E+K H FF+ IDW +
Sbjct: 284 ---------KLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNK 334
Query: 331 VYHQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTETDQMQYKDFPLV-ISERW 387
+Y ++ PP P G FD + +D+ GI + ++ F V I+
Sbjct: 335 LYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDD 394
Query: 388 QAEVAETV 395
+++ +TV
Sbjct: 395 ESQAMQTV 402
Score = 83.8 bits (198), Expect = 1e-15
Identities = 69/227 (30%), Positives = 110/227 (48%), Gaps = 18/227 (7%)
Query: 30 NIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 89
+IQ T + + V IG G + C T +A+K +DK K+ T E I
Sbjct: 415 SIQFT-DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKS----KRDPT----EEIE 465
Query: 90 LSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEV 149
+ L+ G P I+ + + + + +LM GG+L + + F+E E +
Sbjct: 466 I-LLRYGQH-PNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTI 523
Query: 150 ILGLEHMHKRHIVYRDLKPANIL-LDEHGH---VRISDLGLACDFSKKKP--HASVGTHG 203
+E++H + +V+RDLKP+NIL +DE G+ +RI D G A + T
Sbjct: 524 TKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTAN 583
Query: 204 YMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEI 250
++APEVL K GYD++ D +S G +LY +L G++PF EI
Sbjct: 584 FVAPEVL-KRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEI 629
>AL732366-2|CAI40548.1| 740|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 3 protein.
Length = 740
Score = 212 bits (518), Expect = 2e-54
Identities = 129/368 (35%), Positives = 205/368 (55%), Gaps = 39/368 (10%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
+ F + +++G+G FG+V+ +K +D ++YAMK L K +K++ + I++
Sbjct: 66 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVE- 124
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
V+ PFIV + YAF T KL ILD + GGDL LS+ +F E ++KFY AE+ L
Sbjct: 125 ----VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVL 210
L+H+H I+YRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+
Sbjct: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 240
Query: 211 SKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXX 270
++ G+ SADW+SFG +++++L G PF + KD+ E T+TM+
Sbjct: 241 NR-RGHTQSADWWSFGVLMFEMLTGTLPF---QGKDRKE----TMTMILKA--------- 283
Query: 271 XASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQ 330
+ G+P+ SP +SLL L +R+ RLG G +E+K H FF+ IDW +
Sbjct: 284 ---------KLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNK 334
Query: 331 VYHQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTETDQMQYKDFPLV-ISERW 387
+Y ++ PP P G FD + +D+ GI + ++ F V I+
Sbjct: 335 LYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDD 394
Query: 388 QAEVAETV 395
+++ +TV
Sbjct: 395 ESQAMQTV 402
Score = 83.8 bits (198), Expect = 1e-15
Identities = 69/227 (30%), Positives = 110/227 (48%), Gaps = 18/227 (7%)
Query: 30 NIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 89
+IQ T + + V IG G + C T +A+K +DK K+ T E I
Sbjct: 415 SIQFT-DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKS----KRDPT----EEIE 465
Query: 90 LSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEV 149
+ L+ G P I+ + + + + +LM GG+L + + F+E E +
Sbjct: 466 I-LLRYGQH-PNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTI 523
Query: 150 ILGLEHMHKRHIVYRDLKPANIL-LDEHGH---VRISDLGLACDFSKKKP--HASVGTHG 203
+E++H + +V+RDLKP+NIL +DE G+ +RI D G A + T
Sbjct: 524 TKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTAN 583
Query: 204 YMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEI 250
++APEVL K GYD++ D +S G +LY +L G++PF EI
Sbjct: 584 FVAPEVL-KRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEI 629
>AB208933-1|BAD92170.1| 806|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 3 variant protein.
Length = 806
Score = 212 bits (518), Expect = 2e-54
Identities = 129/368 (35%), Positives = 205/368 (55%), Gaps = 39/368 (10%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
+ F + +++G+G FG+V+ +K +D ++YAMK L K +K++ + I++
Sbjct: 133 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVE- 191
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
V+ PFIV + YAF T KL ILD + GGDL LS+ +F E ++KFY AE+ L
Sbjct: 192 ----VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 247
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVL 210
L+H+H I+YRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+
Sbjct: 248 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 307
Query: 211 SKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXX 270
++ G+ SADW+SFG +++++L G PF + KD+ E T+TM+
Sbjct: 308 NR-RGHTQSADWWSFGVLMFEMLTGTLPF---QGKDRKE----TMTMILKA--------- 350
Query: 271 XASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQ 330
+ G+P+ SP +SLL L +R+ RLG G +E+K H FF+ IDW +
Sbjct: 351 ---------KLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNK 401
Query: 331 VYHQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTETDQMQYKDFPLV-ISERW 387
+Y ++ PP P G FD + +D+ GI + ++ F V I+
Sbjct: 402 LYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDD 461
Query: 388 QAEVAETV 395
+++ +TV
Sbjct: 462 ESQAMQTV 469
Score = 83.8 bits (198), Expect = 1e-15
Identities = 69/227 (30%), Positives = 110/227 (48%), Gaps = 18/227 (7%)
Query: 30 NIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 89
+IQ T + + V IG G + C T +A+K +DK K+ T E I
Sbjct: 481 SIQFT-DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKS----KRDPT----EEIE 531
Query: 90 LSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEV 149
+ L+ G P I+ + + + + +LM GG+L + + F+E E +
Sbjct: 532 I-LLRYGQH-PNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTI 589
Query: 150 ILGLEHMHKRHIVYRDLKPANIL-LDEHGH---VRISDLGLACDFSKKKP--HASVGTHG 203
+E++H + +V+RDLKP+NIL +DE G+ +RI D G A + T
Sbjct: 590 TKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTAN 649
Query: 204 YMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEI 250
++APEVL K GYD++ D +S G +LY +L G++PF EI
Sbjct: 650 FVAPEVL-KRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEI 695
>AB102662-1|BAC81131.1| 726|Homo sapiens RPS6KA3 protein.
Length = 726
Score = 212 bits (518), Expect = 2e-54
Identities = 129/368 (35%), Positives = 205/368 (55%), Gaps = 39/368 (10%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
+ F + +++G+G FG+V+ +K +D ++YAMK L K +K++ + I++
Sbjct: 52 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVE- 110
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
V+ PFIV + YAF T KL ILD + GGDL LS+ +F E ++KFY AE+ L
Sbjct: 111 ----VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 166
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVL 210
L+H+H I+YRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+
Sbjct: 167 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 226
Query: 211 SKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXX 270
++ G+ SADW+SFG +++++L G PF + KD+ E T+TM+
Sbjct: 227 NR-RGHTQSADWWSFGVLMFEMLTGTLPF---QGKDRKE----TMTMILKA--------- 269
Query: 271 XASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQ 330
+ G+P+ SP +SLL L +R+ RLG G +E+K H FF+ IDW +
Sbjct: 270 ---------KLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNK 320
Query: 331 VYHQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTETDQMQYKDFPLV-ISERW 387
+Y ++ PP P G FD + +D+ GI + ++ F V I+
Sbjct: 321 LYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDD 380
Query: 388 QAEVAETV 395
+++ +TV
Sbjct: 381 ESQAMQTV 388
Score = 83.8 bits (198), Expect = 1e-15
Identities = 69/227 (30%), Positives = 110/227 (48%), Gaps = 18/227 (7%)
Query: 30 NIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 89
+IQ T + + V IG G + C T +A+K +DK K+ T E I
Sbjct: 401 SIQFT-DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKS----KRDPT----EEIE 451
Query: 90 LSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEV 149
+ L+ G P I+ + + + + +LM GG+L + + F+E E +
Sbjct: 452 I-LLRYGQH-PNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTI 509
Query: 150 ILGLEHMHKRHIVYRDLKPANIL-LDEHGH---VRISDLGLACDFSKKKP--HASVGTHG 203
+E++H + +V+RDLKP+NIL +DE G+ +RI D G A + T
Sbjct: 510 TKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTAN 569
Query: 204 YMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEI 250
++APEVL K GYD++ D +S G +LY +L G++PF EI
Sbjct: 570 FVAPEVL-KRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEI 615
>AL389887-1|CAC16111.2| 745|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 6 protein.
Length = 745
Score = 211 bits (515), Expect = 6e-54
Identities = 126/352 (35%), Positives = 198/352 (56%), Gaps = 40/352 (11%)
Query: 38 FSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 94
F + +++G+G FG+V+ RK D G++YAMK L K +K++ + I++
Sbjct: 73 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVE--- 129
Query: 95 TGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLE 154
V+ PFIV + YAF T KL ILD + GGD+ LS+ +F E ++KFY AE+ L L+
Sbjct: 130 --VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALD 187
Query: 155 HMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLSK 212
H+H+ IVYRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+++
Sbjct: 188 HLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNR 247
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXA 272
G+ SADW+S+G +++++L G PF + KD++E M L
Sbjct: 248 -RGHSQSADWWSYGVLMFEMLTGTLPF---QGKDRNETMNMIL----------------- 286
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+ + G+P+ S +SLL L +R+ RLG G +E+K H+FFA IDW ++Y
Sbjct: 287 -----KAKLGMPQFLSAEAQSLLRMLFKRNPANRLG--SEGVEEIKRHLFFANIDWDKLY 339
Query: 333 HQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTETDQMQYKDFPLV 382
++ PP P G+ + FD + +D+ G+ + +K F V
Sbjct: 340 KREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFV 391
Score = 77.4 bits (182), Expect = 1e-13
Identities = 62/213 (29%), Positives = 99/213 (46%), Gaps = 17/213 (7%)
Query: 44 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGVDCPFIV 103
IG G + C A T +A+K +DK K E + + L+ G P I+
Sbjct: 432 IGVGSYSVCKRCIHATTNMEFAVKIIDKS--KRDPSEEIEI-------LMRYGQH-PNII 481
Query: 104 CMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHMHKRHIVY 163
+ F + + DLM GG+L + + F+E E + ++++H + +V+
Sbjct: 482 TLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVH 541
Query: 164 RDLKPANIL-LDEHG---HVRISDLGLACDFSKKKP--HASVGTHGYMAPEVLSKGTGYD 217
RDLKP+NIL +DE +RI D G A + T ++APEVL + GYD
Sbjct: 542 RDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQ-QGYD 600
Query: 218 SSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEI 250
++ D +S G + Y +L G++PF EI
Sbjct: 601 AACDIWSLGVLFYTMLAGYTPFANGPNDTPEEI 633
>AL354653-1|CAD13486.2| 745|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 6 protein.
Length = 745
Score = 211 bits (515), Expect = 6e-54
Identities = 126/352 (35%), Positives = 198/352 (56%), Gaps = 40/352 (11%)
Query: 38 FSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 94
F + +++G+G FG+V+ RK D G++YAMK L K +K++ + I++
Sbjct: 73 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVE--- 129
Query: 95 TGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLE 154
V+ PFIV + YAF T KL ILD + GGD+ LS+ +F E ++KFY AE+ L L+
Sbjct: 130 --VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALD 187
Query: 155 HMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLSK 212
H+H+ IVYRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+++
Sbjct: 188 HLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNR 247
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXA 272
G+ SADW+S+G +++++L G PF + KD++E M L
Sbjct: 248 -RGHSQSADWWSYGVLMFEMLTGTLPF---QGKDRNETMNMIL----------------- 286
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+ + G+P+ S +SLL L +R+ RLG G +E+K H+FFA IDW ++Y
Sbjct: 287 -----KAKLGMPQFLSAEAQSLLRMLFKRNPANRLG--SEGVEEIKRHLFFANIDWDKLY 339
Query: 333 HQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTETDQMQYKDFPLV 382
++ PP P G+ + FD + +D+ G+ + +K F V
Sbjct: 340 KREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFV 391
Score = 77.4 bits (182), Expect = 1e-13
Identities = 62/213 (29%), Positives = 99/213 (46%), Gaps = 17/213 (7%)
Query: 44 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGVDCPFIV 103
IG G + C A T +A+K +DK K E + + L+ G P I+
Sbjct: 432 IGVGSYSVCKRCIHATTNMEFAVKIIDKS--KRDPSEEIEI-------LMRYGQH-PNII 481
Query: 104 CMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHMHKRHIVY 163
+ F + + DLM GG+L + + F+E E + ++++H + +V+
Sbjct: 482 TLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVH 541
Query: 164 RDLKPANIL-LDEHG---HVRISDLGLACDFSKKKP--HASVGTHGYMAPEVLSKGTGYD 217
RDLKP+NIL +DE +RI D G A + T ++APEVL + GYD
Sbjct: 542 RDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQ-QGYD 600
Query: 218 SSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEI 250
++ D +S G + Y +L G++PF EI
Sbjct: 601 AACDIWSLGVLFYTMLAGYTPFANGPNDTPEEI 633
>AF184965-1|AAF13190.1| 745|Homo sapiens ribosomal S6 kinase
protein.
Length = 745
Score = 211 bits (515), Expect = 6e-54
Identities = 126/352 (35%), Positives = 198/352 (56%), Gaps = 40/352 (11%)
Query: 38 FSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 94
F + +++G+G FG+V+ RK D G++YAMK L K +K++ + I++
Sbjct: 73 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVE--- 129
Query: 95 TGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLE 154
V+ PFIV + YAF T KL ILD + GGD+ LS+ +F E ++KFY AE+ L L+
Sbjct: 130 --VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALD 187
Query: 155 HMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLSK 212
H+H+ IVYRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+++
Sbjct: 188 HLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNR 247
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXA 272
G+ SADW+S+G +++++L G PF + KD++E M L
Sbjct: 248 -RGHSQSADWWSYGVLMFEMLTGTLPF---QGKDRNETMNMIL----------------- 286
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+ + G+P+ S +SLL L +R+ RLG G +E+K H+FFA IDW ++Y
Sbjct: 287 -----KAKLGMPQFLSAEAQSLLRMLFKRNPANRLG--SEGVEEIKRHLFFANIDWDKLY 339
Query: 333 HQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTETDQMQYKDFPLV 382
++ PP P G+ + FD + +D+ G+ + +K F V
Sbjct: 340 KREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFV 391
Score = 77.4 bits (182), Expect = 1e-13
Identities = 62/213 (29%), Positives = 99/213 (46%), Gaps = 17/213 (7%)
Query: 44 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGVDCPFIV 103
IG G + C A T +A+K +DK K E + + L+ G P I+
Sbjct: 432 IGVGSYSVCKRCIHATTNMEFAVKIIDKS--KRDPSEEIEI-------LMRYGQH-PNII 481
Query: 104 CMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHMHKRHIVY 163
+ F + + DLM GG+L + + F+E E + ++++H + +V+
Sbjct: 482 TLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVH 541
Query: 164 RDLKPANIL-LDEHG---HVRISDLGLACDFSKKKP--HASVGTHGYMAPEVLSKGTGYD 217
RDLKP+NIL +DE +RI D G A + T ++APEVL + GYD
Sbjct: 542 RDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQ-QGYD 600
Query: 218 SSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEI 250
++ D +S G + Y +L G++PF EI
Sbjct: 601 AACDIWSLGVLFYTMLAGYTPFANGPNDTPEEI 633
>CR536566-1|CAG38803.1| 745|Homo sapiens RPS6KA6 protein.
Length = 745
Score = 210 bits (513), Expect = 1e-53
Identities = 129/352 (36%), Positives = 198/352 (56%), Gaps = 40/352 (11%)
Query: 38 FSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 94
F + +++G+G FG+V+ RK D G++YAMK L K +K++ G ER +L
Sbjct: 73 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVR-GRVRTKMERDIL---- 127
Query: 95 TGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLE 154
V+ PFIV + YAF T KL ILD + GGD+ LS+ +F E ++KFY AE+ L L+
Sbjct: 128 VEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALD 187
Query: 155 HMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLSK 212
H+H+ IVYRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+++
Sbjct: 188 HLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNR 247
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXA 272
G+ SADW+S+G +++++L G PF + KD++E M L
Sbjct: 248 -RGHSQSADWWSYGVLMFEMLTGTLPF---QGKDRNETMNMIL----------------- 286
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+ + G+P+ S +SLL L +R+ RLG G +E+K H+FFA IDW ++Y
Sbjct: 287 -----KAKLGMPQLLSAEAQSLLRMLFKRNPANRLG--SEGVEEIKRHLFFANIDWDKLY 339
Query: 333 HQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTETDQMQYKDFPLV 382
+ PP P G+ + FD + +D+ G+ + +K F V
Sbjct: 340 KGEVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFV 391
Score = 77.4 bits (182), Expect = 1e-13
Identities = 62/213 (29%), Positives = 99/213 (46%), Gaps = 17/213 (7%)
Query: 44 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGVDCPFIV 103
IG G + C A T +A+K +DK K E + + L+ G P I+
Sbjct: 432 IGVGSYSVCKRCIHATTNMEFAVKIIDKS--KRDPSEEIEI-------LMRYGQH-PNII 481
Query: 104 CMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHMHKRHIVY 163
+ F + + DLM GG+L + + F+E E + ++++H + +V+
Sbjct: 482 TLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVH 541
Query: 164 RDLKPANIL-LDEHG---HVRISDLGLACDFSKKKP--HASVGTHGYMAPEVLSKGTGYD 217
RDLKP+NIL +DE +RI D G A + T ++APEVL + GYD
Sbjct: 542 RDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQ-QGYD 600
Query: 218 SSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEI 250
++ D +S G + Y +L G++PF EI
Sbjct: 601 AACDIWSLGVLFYTMLAGYTPFANGPNDTPEEI 633
>BC017187-1|AAH17187.1| 549|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 5 protein.
Length = 549
Score = 208 bits (509), Expect = 3e-53
Identities = 128/339 (37%), Positives = 185/339 (54%), Gaps = 39/339 (11%)
Query: 35 MNDFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETL-ALNERIML 90
+ +F + +++G G +G+V+ RK DTGK+YAMK L K I K T ER +L
Sbjct: 46 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 105
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVI 150
+ PF+V + YAF T KL ILD +NGG+L HLSQ F E E++ Y E++
Sbjct: 106 EHIRQS---PFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIV 162
Query: 151 LGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF---SKKKPHASVGTHGYMAP 207
L LEH+HK I+YRD+K NILLD +GHV ++D GL+ +F ++ ++ GT YMAP
Sbjct: 163 LALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAP 222
Query: 208 EVLSKG-TGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKH-EIDKMTLTMLRNXXXXX 265
+++ G +G+D + DW+S G ++Y+LL G SPF K+ EI + L
Sbjct: 223 DIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRIL---------- 272
Query: 266 XXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAG 325
+ E P+ S K L++ LL +D KRLGC R ADE+KEH+FF
Sbjct: 273 ------------KSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQK 320
Query: 326 IDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTK 364
I+W + +K P P D D+ +F EE T+
Sbjct: 321 INWDDLAAKKVPAPFKPV-----IRDELDVSNFAEEFTE 354
Score = 53.2 bits (122), Expect = 2e-06
Identities = 34/125 (27%), Positives = 58/125 (46%), Gaps = 9/125 (7%)
Query: 44 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGVDCPFIV 103
+G G F C + + +A+K + K+ Q E AL + G P IV
Sbjct: 432 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALK-------LCEGH--PNIV 482
Query: 104 CMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHMHKRHIVY 163
+ FH +++L+NGG+L + + F+E E + +++ + HMH +V+
Sbjct: 483 KLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVH 542
Query: 164 RDLKP 168
RDLKP
Sbjct: 543 RDLKP 547
>AF090421-1|AAC69577.1| 809|Homo sapiens ribosome S6 protein kinase
protein.
Length = 809
Score = 208 bits (509), Expect = 3e-53
Identities = 128/339 (37%), Positives = 185/339 (54%), Gaps = 39/339 (11%)
Query: 35 MNDFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETL-ALNERIML 90
+ +F + +++G G +G+V+ RK DTGK+YAMK L K I K T ER +L
Sbjct: 46 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 105
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVI 150
+ PF+V + YAF T KL ILD +NGG+L HLSQ F E E++ Y E++
Sbjct: 106 EHIRQS---PFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIV 162
Query: 151 LGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF---SKKKPHASVGTHGYMAP 207
L LEH+HK I+YRD+K NILLD +GHV ++D GL+ +F ++ ++ GT YMAP
Sbjct: 163 LALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAP 222
Query: 208 EVLSKG-TGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKH-EIDKMTLTMLRNXXXXX 265
+++ G +G+D + DW+S G ++Y+LL G SPF K+ EI + L
Sbjct: 223 DIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRIL---------- 272
Query: 266 XXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAG 325
+ E P+ S K L++ LL +D KRLGC R ADE+KEH+FF
Sbjct: 273 ------------KSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQK 320
Query: 326 IDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTK 364
I+W + +K P P D D+ +F EE T+
Sbjct: 321 INWDDLAAKKVPAPFKPV-----IRDELDVSNFAEEFTE 354
Score = 83.0 bits (196), Expect = 3e-15
Identities = 66/219 (30%), Positives = 102/219 (46%), Gaps = 24/219 (10%)
Query: 100 PFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHMHKR 159
P IV + FH +++L+NGG+L L + F+E E + +++ L HMH
Sbjct: 479 PNIVKLHEVFHDQLHTFLVMELLNGGELFDALRKKKHFSETEASYIMRKLVSALSHMHDL 538
Query: 160 HIVYRDLKPANILL-DEHGHVRISDLGLACDFSKKKP------HASVGTHGYMAPEVLSK 212
+V+RDLKP N+L DE+ ++ I + F++ KP T PE+L++
Sbjct: 539 GVVHRDLKPENLLFTDENDNLEIKIIDFG--FARLKPPDNQPLKTPCFTLHSCRPELLNQ 596
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXA 272
GYD S D +S G +LY +L G PF+ H D+ + +++
Sbjct: 597 -NGYDESCDLWSLGVILYTMLSGQVPFQSH---DRSLTCTSAVEIMKKIKKGDFSFE--- 649
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKG 311
GE + V S K L++GLL D NKRL G
Sbjct: 650 ----GEAWKNV----SQEAKDLIQGLLTVDPNKRLKMSG 680
>AF080000-1|AAD23915.1| 802|Homo sapiens RSK-like protein kinase
RLPK protein.
Length = 802
Score = 208 bits (509), Expect = 3e-53
Identities = 128/339 (37%), Positives = 185/339 (54%), Gaps = 39/339 (11%)
Query: 35 MNDFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETL-ALNERIML 90
+ +F + +++G G +G+V+ RK DTGK+YAMK L K I K T ER +L
Sbjct: 46 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 105
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVI 150
+ PF+V + YAF T KL ILD +NGG+L HLSQ F E E++ Y E++
Sbjct: 106 EHIRQS---PFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIV 162
Query: 151 LGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF---SKKKPHASVGTHGYMAP 207
L LEH+HK I+YRD+K NILLD +GHV ++D GL+ +F ++ ++ GT YMAP
Sbjct: 163 LALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAP 222
Query: 208 EVLSKG-TGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKH-EIDKMTLTMLRNXXXXX 265
+++ G +G+D + DW+S G ++Y+LL G SPF K+ EI + L
Sbjct: 223 DIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRIL---------- 272
Query: 266 XXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAG 325
+ E P+ S K L++ LL +D KRLGC R ADE+KEH+FF
Sbjct: 273 ------------KSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQK 320
Query: 326 IDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTK 364
I+W + +K P P D D+ +F EE T+
Sbjct: 321 INWDDLAAKKVPAPFKPV-----IRDELDVSNFAEEFTE 354
Score = 91.5 bits (217), Expect = 7e-18
Identities = 78/275 (28%), Positives = 124/275 (45%), Gaps = 33/275 (12%)
Query: 44 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGVDCPFIV 103
+G G F C + + +A+K + K+ Q E AL + G P IV
Sbjct: 432 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALK-------LCEGH--PNIV 482
Query: 104 CMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHMHKRHIVY 163
+ FH +++L+NGG+L + + F+E E + +++ + HMH +V+
Sbjct: 483 KLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVH 542
Query: 164 RDLKPANILL-DEHGHVRISDLGLACDFSKKKP------HASVGTHGYMAPEVLSKGTGY 216
RDLKP N+L DE+ ++ I + F++ KP T Y APE+L++ GY
Sbjct: 543 RDLKPENLLFTDENDNLEIKIIDFG--FARLKPPDNQPLKTPCFTLHYAAPELLNQ-NGY 599
Query: 217 DSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXASTTL 276
D S D +S G +LY +L G PF+ H D+ + +++
Sbjct: 600 DESCDLWSLGVILYTMLSGQVPFQSH---DRSLTCTSAVEIMKKIKKGDFSFE------- 649
Query: 277 GEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKG 311
GE + V S K L++GLL D NKRL G
Sbjct: 650 GEAWKNV----SQEAKDLIQGLLTVDPNKRLKMSG 680
>AF074393-1|AAC31171.1| 802|Homo sapiens nuclear mitogen- and
stress-activated protein kinase-1 protein.
Length = 802
Score = 208 bits (509), Expect = 3e-53
Identities = 128/339 (37%), Positives = 185/339 (54%), Gaps = 39/339 (11%)
Query: 35 MNDFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETL-ALNERIML 90
+ +F + +++G G +G+V+ RK DTGK+YAMK L K I K T ER +L
Sbjct: 46 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 105
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVI 150
+ PF+V + YAF T KL ILD +NGG+L HLSQ F E E++ Y E++
Sbjct: 106 EHIRQS---PFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIV 162
Query: 151 LGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF---SKKKPHASVGTHGYMAP 207
L LEH+HK I+YRD+K NILLD +GHV ++D GL+ +F ++ ++ GT YMAP
Sbjct: 163 LALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAP 222
Query: 208 EVLSKG-TGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKH-EIDKMTLTMLRNXXXXX 265
+++ G +G+D + DW+S G ++Y+LL G SPF K+ EI + L
Sbjct: 223 DIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRIL---------- 272
Query: 266 XXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAG 325
+ E P+ S K L++ LL +D KRLGC R ADE+KEH+FF
Sbjct: 273 ------------KSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQK 320
Query: 326 IDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTK 364
I+W + +K P P D D+ +F EE T+
Sbjct: 321 INWDDLAAKKVPAPFKPV-----IRDELDVSNFAEEFTE 354
Score = 91.5 bits (217), Expect = 7e-18
Identities = 78/275 (28%), Positives = 124/275 (45%), Gaps = 33/275 (12%)
Query: 44 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGVDCPFIV 103
+G G F C + + +A+K + K+ Q E AL + G P IV
Sbjct: 432 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALK-------LCEGH--PNIV 482
Query: 104 CMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHMHKRHIVY 163
+ FH +++L+NGG+L + + F+E E + +++ + HMH +V+
Sbjct: 483 KLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVH 542
Query: 164 RDLKPANILL-DEHGHVRISDLGLACDFSKKKP------HASVGTHGYMAPEVLSKGTGY 216
RDLKP N+L DE+ ++ I + F++ KP T Y APE+L++ GY
Sbjct: 543 RDLKPENLLFTDENDNLEIKIIDFG--FARLKPPDNQPLKTPCFTLHYAAPELLNQ-NGY 599
Query: 217 DSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXASTTL 276
D S D +S G +LY +L G PF+ H D+ + +++
Sbjct: 600 DESCDLWSLGVILYTMLSGQVPFQSH---DRSLTCTSAVEIMKKIKKGDFSFE------- 649
Query: 277 GEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKG 311
GE + V S K L++GLL D NKRL G
Sbjct: 650 GEAWKNV----SQEAKDLIQGLLTVDPNKRLKMSG 680
>BC047896-1|AAH47896.1| 524|Homo sapiens RPS6KA4 protein protein.
Length = 524
Score = 204 bits (498), Expect = 7e-52
Identities = 123/340 (36%), Positives = 181/340 (53%), Gaps = 36/340 (10%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMK-QGETLALNER 87
++++ +F + +++G G +G+V+ RKA D GK+YAMK L K + + + + ER
Sbjct: 27 KVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTER 86
Query: 88 IMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAA 147
+L LV PF+V + YAF T KL ILD ++GG++ HL Q F EAE++ Y
Sbjct: 87 SVLELVR---QAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGG 143
Query: 148 EVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF---SKKKPHASVGTHGY 204
E++L LEH+HK I+YRDLK N+LLD GH+ ++D GL+ +F K++ + GT Y
Sbjct: 144 EIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEY 203
Query: 205 MAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXX 264
MAPE++ TG+ + DW+S G +L++LL G SPF TL RN
Sbjct: 204 MAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPF--------------TLEGERNTQAE 249
Query: 265 XXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFA 324
S P P + LL+ LL +D KRLG +GA EV+ H FF
Sbjct: 250 VSRRILKCSPPF-------PPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQ 302
Query: 325 GIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTK 364
G+DW + +K P P D+G+F EE T+
Sbjct: 303 GLDWVALAARKIPAPFRP-----QIRSELDVGNFAEEFTR 337
>BC028079-1|AAH28079.1| 556|Homo sapiens Unknown (protein for
IMAGE:5216639) protein.
Length = 556
Score = 204 bits (498), Expect = 7e-52
Identities = 123/340 (36%), Positives = 181/340 (53%), Gaps = 36/340 (10%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMK-QGETLALNER 87
++++ +F + +++G G +G+V+ RKA D GK+YAMK L K + + + + ER
Sbjct: 27 KVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTER 86
Query: 88 IMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAA 147
+L LV PF+V + YAF T KL ILD ++GG++ HL Q F EAE++ Y
Sbjct: 87 SVLELVR---QAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGG 143
Query: 148 EVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF---SKKKPHASVGTHGY 204
E++L LEH+HK I+YRDLK N+LLD GH+ ++D GL+ +F K++ + GT Y
Sbjct: 144 EIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEY 203
Query: 205 MAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXX 264
MAPE++ TG+ + DW+S G +L++LL G SPF TL RN
Sbjct: 204 MAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPF--------------TLEGERNTQAE 249
Query: 265 XXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFA 324
S P P + LL+ LL +D KRLG +GA EV+ H FF
Sbjct: 250 VSRRILKCSPPF-------PPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQ 302
Query: 325 GIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTK 364
G+DW + +K P P D+G+F EE T+
Sbjct: 303 GLDWVALAARKIPAPFRP-----QIRSELDVGNFAEEFTR 337
Score = 57.6 bits (133), Expect = 1e-07
Identities = 45/148 (30%), Positives = 72/148 (48%), Gaps = 13/148 (8%)
Query: 44 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGVDCPFIV 103
+G+G F CR+ +G+ +A+K L ++ Q E AL R+ S P +V
Sbjct: 417 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAAL--RLCQSH-------PNVV 467
Query: 104 CMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHMHKR-HIV 162
+ H +L+L+ GG+L H+ + F+E+E ++ + MH+ +V
Sbjct: 468 NLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVV 527
Query: 163 YRDLKPANILL--DEHG-HVRISDLGLA 187
+RDLKP NIL D G V+I D G A
Sbjct: 528 HRDLKPENILYADDTPGAPVKIIDFGFA 555
>AK223561-1|BAD97281.1| 765|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 4 isoform b variant protein.
Length = 765
Score = 204 bits (498), Expect = 7e-52
Identities = 123/340 (36%), Positives = 181/340 (53%), Gaps = 36/340 (10%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMK-QGETLALNER 87
++++ +F + +++G G +G+V+ RKA D GK+YAMK L K + + + + ER
Sbjct: 27 KVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTER 86
Query: 88 IMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAA 147
+L LV PF+V + YAF T KL ILD ++GG++ HL Q F EAE++ Y
Sbjct: 87 SVLELVR---QAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGG 143
Query: 148 EVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF---SKKKPHASVGTHGY 204
E++L LEH+HK I+YRDLK N+LLD GH+ ++D GL+ +F K++ + GT Y
Sbjct: 144 EIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEY 203
Query: 205 MAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXX 264
MAPE++ TG+ + DW+S G +L++LL G SPF TL RN
Sbjct: 204 MAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPF--------------TLEGERNTQAE 249
Query: 265 XXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFA 324
S P P + LL+ LL +D KRLG +GA EV+ H FF
Sbjct: 250 VSRRILKCSPPF-------PPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQ 302
Query: 325 GIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTK 364
G+DW + +K P P D+G+F EE T+
Sbjct: 303 GLDWVALAARKIPAPFRP-----QIRSELDVGNFAEEFTR 337
Score = 83.8 bits (198), Expect = 1e-15
Identities = 65/205 (31%), Positives = 101/205 (49%), Gaps = 19/205 (9%)
Query: 44 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGVDCPFIV 103
+G+G F CR+ +G+ +A+K L ++ Q E AL R+ S P +V
Sbjct: 410 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAAL--RLCQSH-------PNVV 460
Query: 104 CMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHMHKRH-IV 162
+ H +L+L+ GG+L H+ + F+E+E ++ + MH+ +V
Sbjct: 461 NLHEVHHDQPHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVV 520
Query: 163 YRDLKPANILL--DEHGH-VRISDLGLACDFSKKKPHASVGTH----GYMAPEVLSKGTG 215
+RDLKP NIL D G V+I D G A + P + T Y APE+L++ G
Sbjct: 521 HRDLKPENILYADDTPGAPVKIIDFGFA-RLRPQSPGVPMQTPCFTLQYAAPELLAQ-QG 578
Query: 216 YDSSADWFSFGCMLYKLLKGHSPFR 240
YD S D +S G +LY +L G PF+
Sbjct: 579 YDESCDLWSLGVILYMMLSGQVPFQ 603
>AJ010119-1|CAA09009.1| 772|Homo sapiens Ribosomal protein kinase B
(RSK-B) protein.
Length = 772
Score = 204 bits (498), Expect = 7e-52
Identities = 123/340 (36%), Positives = 181/340 (53%), Gaps = 36/340 (10%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMK-QGETLALNER 87
++++ +F + +++G G +G+V+ RKA D GK+YAMK L K + + + + ER
Sbjct: 27 KVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTER 86
Query: 88 IMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAA 147
+L LV PF+V + YAF T KL ILD ++GG++ HL Q F EAE++ Y
Sbjct: 87 SVLELVR---QAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGG 143
Query: 148 EVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF---SKKKPHASVGTHGY 204
E++L LEH+HK I+YRDLK N+LLD GH+ ++D GL+ +F K++ + GT Y
Sbjct: 144 EIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEY 203
Query: 205 MAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXX 264
MAPE++ TG+ + DW+S G +L++LL G SPF TL RN
Sbjct: 204 MAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPF--------------TLEGERNTQAE 249
Query: 265 XXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFA 324
S P P + LL+ LL +D KRLG +GA EV+ H FF
Sbjct: 250 VSRRILKCSPPF-------PPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQ 302
Query: 325 GIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTK 364
G+DW + +K P P D+G+F EE T+
Sbjct: 303 GLDWVALAARKIPAPFRP-----QIRSELDVGNFAEEFTR 337
Score = 82.6 bits (195), Expect = 3e-15
Identities = 65/205 (31%), Positives = 101/205 (49%), Gaps = 19/205 (9%)
Query: 44 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGVDCPFIV 103
+G+G F CR+ +G+ +A+K L ++ Q E AL R+ S P +V
Sbjct: 417 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAAL--RLCQSH-------PNVV 467
Query: 104 CMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHMHKRH-IV 162
+ H +L+L+ GG+L H+ + F+E+E ++ + MH+ +V
Sbjct: 468 NLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVV 527
Query: 163 YRDLKPANILL--DEHGH-VRISDLGLACDFSKKKPHASVGTH----GYMAPEVLSKGTG 215
+RDLKP NIL D G V+I D G A + P + T Y APE+L++ G
Sbjct: 528 HRDLKPENILYADDTPGAPVKIIDFGFA-RLRPQSPGVPMQTPCFTLQYAAPELLAQ-QG 585
Query: 216 YDSSADWFSFGCMLYKLLKGHSPFR 240
YD S D +S G +LY +L G PF+
Sbjct: 586 YDESCDLWSLGVILYMMLSGQVPFQ 610
>AF074715-1|AAC67395.1| 705|Homo sapiens mitogen- and
stress-activated protein kinase-2 protein.
Length = 705
Score = 204 bits (498), Expect = 7e-52
Identities = 123/340 (36%), Positives = 181/340 (53%), Gaps = 36/340 (10%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMK-QGETLALNER 87
++++ +F + +++G G +G+V+ RKA D GK+YAMK L K + + + + ER
Sbjct: 11 KVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTER 70
Query: 88 IMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAA 147
+L LV PF+V + YAF T KL ILD ++GG++ HL Q F EAE++ Y
Sbjct: 71 SVLELVR---QAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGG 127
Query: 148 EVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF---SKKKPHASVGTHGY 204
E++L LEH+HK I+YRDLK N+LLD GH+ ++D GL+ +F K++ + GT Y
Sbjct: 128 EIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEY 187
Query: 205 MAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXX 264
MAPE++ TG+ + DW+S G +L++LL G SPF TL RN
Sbjct: 188 MAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPF--------------TLEGERNTQAE 233
Query: 265 XXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFA 324
S P P + LL+ LL +D KRLG +GA EV+ H FF
Sbjct: 234 VSRRILKCSPPF-------PPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQ 286
Query: 325 GIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTK 364
G+DW + +K P P D+G+F EE T+
Sbjct: 287 GLDWVALAARKIPAPFRP-----QIRSELDVGNFAEEFTR 321
Score = 82.6 bits (195), Expect = 3e-15
Identities = 65/205 (31%), Positives = 101/205 (49%), Gaps = 19/205 (9%)
Query: 44 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGVDCPFIV 103
+G+G F CR+ +G+ +A+K L ++ Q E AL R+ S P +V
Sbjct: 395 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAAL--RLCQSH-------PNVV 445
Query: 104 CMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHMHKRH-IV 162
+ H +L+L+ GG+L H+ + F+E+E ++ + MH+ +V
Sbjct: 446 NLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVV 505
Query: 163 YRDLKPANILL--DEHGH-VRISDLGLACDFSKKKPHASVGTH----GYMAPEVLSKGTG 215
+RDLKP NIL D G V+I D G A + P + T Y APE+L++ G
Sbjct: 506 HRDLKPENILYADDTPGAPVKIIDFGFA-RLRPQSPGVPMQTPCFTLQYAAPELLAQ-QG 563
Query: 216 YDSSADWFSFGCMLYKLLKGHSPFR 240
YD S D +S G +LY +L G PF+
Sbjct: 564 YDESCDLWSLGVILYMMLSGQVPFQ 588
>X85106-1|CAA59427.1| 733|Homo sapiens ribosomal S6 kinase protein.
Length = 733
Score = 203 bits (496), Expect = 1e-51
Identities = 124/356 (34%), Positives = 192/356 (53%), Gaps = 38/356 (10%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
+ F + +++G+G +G+V+ RK +D G++YAMK L K +K++ + I+
Sbjct: 57 SQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAE- 115
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
V+ PFIV + YAF T KL ILD + GGDL LS+ +F E ++KFY AE+ L
Sbjct: 116 ----VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 171
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVL 210
L+H+H I+YRDLKP NILLDE GH++I+D GL+ + K+ ++ GT YMAPEV+
Sbjct: 172 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 231
Query: 211 SKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXX 270
++ G+ SADW+SFG +++++L G PF + KD+ E T+ ++
Sbjct: 232 NR-RGHTQSADWWSFGVLMFEMLTGSLPF---QGKDRKE----TMALILKA--------- 274
Query: 271 XASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQ 330
+ G+P+ S +SLL L +R+ RLG G +E+K H FF IDW
Sbjct: 275 ---------KLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNT 325
Query: 331 VYHQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTETDQMQYKDFPLVIS 384
+Y ++ PP P G FD + D+ G+ + ++ F V S
Sbjct: 326 LYRKEIKPPFKPALGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVAS 381
Score = 81.8 bits (193), Expect = 6e-15
Identities = 65/227 (28%), Positives = 104/227 (45%), Gaps = 18/227 (7%)
Query: 30 NIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 89
NI T + + + IG G + C T YA+K +DK K E + +
Sbjct: 408 NIHFT-DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKS--KRDPSEEIEI----- 459
Query: 90 LSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEV 149
L+ G P I+ + + + +++LM GG+L + + F+E E +
Sbjct: 460 --LLRYGQH-PNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTI 516
Query: 150 ILGLEHMHKRHIVYRDLKPANILL-DEHG---HVRISDLGLACDFSKKKP--HASVGTHG 203
++++H + +V+RDLKP+NIL DE G +R+ D G A T
Sbjct: 517 TKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTAN 576
Query: 204 YMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEI 250
++APEVL K GYD++ D +S G +LY +L G +PF EI
Sbjct: 577 FVAPEVL-KRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEI 622
>L07598-1|AAC82496.1| 540|Homo sapiens ribosomal protein S6 kinase
2 protein.
Length = 540
Score = 203 bits (496), Expect = 1e-51
Identities = 124/356 (34%), Positives = 193/356 (54%), Gaps = 38/356 (10%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
+ F + +++G+G +G+V+ RK +D G++YAMK L K +K++ + I+
Sbjct: 58 SQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAE- 116
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
V+ PFIV + YAF T KL ILD + GGDL LS+ +F E ++KFY AE+ L
Sbjct: 117 ----VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 172
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVL 210
L+H+H I+YRDLKP NILLDE GH++I+D GL+ + K+ ++ GT YMAPEV+
Sbjct: 173 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 232
Query: 211 SKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXX 270
++ G+ SADW+SFG +++++L G PF + KD+ E T++++
Sbjct: 233 NR-RGHTQSADWWSFGVLMFEMLTGALPF---QGKDRKE----TMSLILKA--------- 275
Query: 271 XASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQ 330
+ G+P+ S +SLL L +R+ RLG G +E+K H FF IDW
Sbjct: 276 ---------KLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNT 326
Query: 331 VYHQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTETDQMQYKDFPLVIS 384
+Y ++ PP P G FD + D+ G+ + ++ F V S
Sbjct: 327 LYRKEIKPPFKPALGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVAS 382
Score = 47.6 bits (108), Expect = 1e-04
Identities = 36/143 (25%), Positives = 65/143 (45%), Gaps = 11/143 (7%)
Query: 30 NIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 89
NI T + + + IG G + C T YA+K + K K E + +
Sbjct: 409 NIHFT-DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIGKS--KRDPSEEIEI----- 460
Query: 90 LSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEV 149
L+ G P I+ + + + +++LM GG+L + + F+E E +
Sbjct: 461 --LLRYGQH-PNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTI 517
Query: 150 ILGLEHMHKRHIVYRDLKPANIL 172
++++H + +V+RDLKP+NIL
Sbjct: 518 TKTMDYLHSQGVVHRDLKPSNIL 540
>Z98049-1|CAI20579.1| 733|Homo sapiens ribosomal protein S6 kinase,
90kDa, polypeptide 2 protein.
Length = 733
Score = 203 bits (495), Expect = 2e-51
Identities = 124/356 (34%), Positives = 192/356 (53%), Gaps = 38/356 (10%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
+ F + +++G+G +G+V+ RK +D G++YAMK L K +K++ + I+
Sbjct: 57 SQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAE- 115
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
V+ PFIV + YAF T KL ILD + GGDL LS+ +F E ++KFY AE+ L
Sbjct: 116 ----VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 171
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVL 210
L+H+H I+YRDLKP NILLDE GH++I+D GL+ + K+ ++ GT YMAPEV+
Sbjct: 172 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 231
Query: 211 SKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXX 270
++ G+ SADW+SFG +++++L G PF + KD+ E T+ ++
Sbjct: 232 NR-RGHTQSADWWSFGVLMFEMLTGSLPF---QGKDRKE----TMALILKA--------- 274
Query: 271 XASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQ 330
+ G+P+ S +SLL L +R+ RLG G +E+K H FF IDW
Sbjct: 275 ---------KLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNT 325
Query: 331 VYHQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTETDQMQYKDFPLVIS 384
+Y ++ PP P G FD + D+ G+ + ++ F V S
Sbjct: 326 LYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVAS 381
Score = 81.8 bits (193), Expect = 6e-15
Identities = 65/227 (28%), Positives = 104/227 (45%), Gaps = 18/227 (7%)
Query: 30 NIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 89
NI T + + + IG G + C T YA+K +DK K E + +
Sbjct: 408 NIHFT-DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKS--KRDPSEEIEI----- 459
Query: 90 LSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEV 149
L+ G P I+ + + + +++LM GG+L + + F+E E +
Sbjct: 460 --LLRYGQH-PNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTI 516
Query: 150 ILGLEHMHKRHIVYRDLKPANILL-DEHG---HVRISDLGLACDFSKKKP--HASVGTHG 203
++++H + +V+RDLKP+NIL DE G +R+ D G A T
Sbjct: 517 TKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTAN 576
Query: 204 YMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEI 250
++APEVL K GYD++ D +S G +LY +L G +PF EI
Sbjct: 577 FVAPEVL-KRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEI 622
>BC002363-1|AAH02363.1| 733|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 2 protein.
Length = 733
Score = 203 bits (495), Expect = 2e-51
Identities = 124/356 (34%), Positives = 192/356 (53%), Gaps = 38/356 (10%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
+ F + +++G+G +G+V+ RK +D G++YAMK L K +K++ + I+
Sbjct: 57 SQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAE- 115
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
V+ PFIV + YAF T KL ILD + GGDL LS+ +F E ++KFY AE+ L
Sbjct: 116 ----VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 171
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVL 210
L+H+H I+YRDLKP NILLDE GH++I+D GL+ + K+ ++ GT YMAPEV+
Sbjct: 172 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 231
Query: 211 SKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXX 270
++ G+ SADW+SFG +++++L G PF + KD+ E T+ ++
Sbjct: 232 NR-RGHTQSADWWSFGVLMFEMLTGSLPF---QGKDRKE----TMALILKA--------- 274
Query: 271 XASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQ 330
+ G+P+ S +SLL L +R+ RLG G +E+K H FF IDW
Sbjct: 275 ---------KLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNT 325
Query: 331 VYHQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTETDQMQYKDFPLVIS 384
+Y ++ PP P G FD + D+ G+ + ++ F V S
Sbjct: 326 LYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVAS 381
Score = 81.8 bits (193), Expect = 6e-15
Identities = 65/227 (28%), Positives = 104/227 (45%), Gaps = 18/227 (7%)
Query: 30 NIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 89
NI T + + + IG G + C T YA+K +DK K E + +
Sbjct: 408 NIHFT-DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKS--KRDPSEEIEI----- 459
Query: 90 LSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEV 149
L+ G P I+ + + + +++LM GG+L + + F+E E +
Sbjct: 460 --LLRYGQH-PNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTI 516
Query: 150 ILGLEHMHKRHIVYRDLKPANILL-DEHG---HVRISDLGLACDFSKKKP--HASVGTHG 203
++++H + +V+RDLKP+NIL DE G +R+ D G A T
Sbjct: 517 TKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTAN 576
Query: 204 YMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEI 250
++APEVL K GYD++ D +S G +LY +L G +PF EI
Sbjct: 577 FVAPEVL-KRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEI 622
>AL022069-2|CAI19651.1| 733|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 2 protein.
Length = 733
Score = 203 bits (495), Expect = 2e-51
Identities = 124/356 (34%), Positives = 192/356 (53%), Gaps = 38/356 (10%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
+ F + +++G+G +G+V+ RK +D G++YAMK L K +K++ + I+
Sbjct: 57 SQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAE- 115
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
V+ PFIV + YAF T KL ILD + GGDL LS+ +F E ++KFY AE+ L
Sbjct: 116 ----VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 171
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVL 210
L+H+H I+YRDLKP NILLDE GH++I+D GL+ + K+ ++ GT YMAPEV+
Sbjct: 172 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 231
Query: 211 SKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXX 270
++ G+ SADW+SFG +++++L G PF + KD+ E T+ ++
Sbjct: 232 NR-RGHTQSADWWSFGVLMFEMLTGSLPF---QGKDRKE----TMALILKA--------- 274
Query: 271 XASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQ 330
+ G+P+ S +SLL L +R+ RLG G +E+K H FF IDW
Sbjct: 275 ---------KLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNT 325
Query: 331 VYHQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTETDQMQYKDFPLVIS 384
+Y ++ PP P G FD + D+ G+ + ++ F V S
Sbjct: 326 LYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVAS 381
Score = 81.8 bits (193), Expect = 6e-15
Identities = 65/227 (28%), Positives = 104/227 (45%), Gaps = 18/227 (7%)
Query: 30 NIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 89
NI T + + + IG G + C T YA+K +DK K E + +
Sbjct: 408 NIHFT-DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKS--KRDPSEEIEI----- 459
Query: 90 LSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEV 149
L+ G P I+ + + + +++LM GG+L + + F+E E +
Sbjct: 460 --LLRYGQH-PNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTI 516
Query: 150 ILGLEHMHKRHIVYRDLKPANILL-DEHG---HVRISDLGLACDFSKKKP--HASVGTHG 203
++++H + +V+RDLKP+NIL DE G +R+ D G A T
Sbjct: 517 TKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTAN 576
Query: 204 YMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEI 250
++APEVL K GYD++ D +S G +LY +L G +PF EI
Sbjct: 577 FVAPEVL-KRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEI 622
>AB209116-1|BAD92353.1| 806|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 2 isoform b variant protein.
Length = 806
Score = 203 bits (495), Expect = 2e-51
Identities = 124/356 (34%), Positives = 192/356 (53%), Gaps = 38/356 (10%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
+ F + +++G+G +G+V+ RK +D G++YAMK L K +K++ + I+
Sbjct: 130 SQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAE- 188
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
V+ PFIV + YAF T KL ILD + GGDL LS+ +F E ++KFY AE+ L
Sbjct: 189 ----VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 244
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVL 210
L+H+H I+YRDLKP NILLDE GH++I+D GL+ + K+ ++ GT YMAPEV+
Sbjct: 245 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 304
Query: 211 SKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXX 270
++ G+ SADW+SFG +++++L G PF + KD+ E T+ ++
Sbjct: 305 NR-RGHTQSADWWSFGVLMFEMLTGSLPF---QGKDRKE----TMALILKA--------- 347
Query: 271 XASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQ 330
+ G+P+ S +SLL L +R+ RLG G +E+K H FF IDW
Sbjct: 348 ---------KLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNT 398
Query: 331 VYHQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTETDQMQYKDFPLVIS 384
+Y ++ PP P G FD + D+ G+ + ++ F V S
Sbjct: 399 LYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVAS 454
Score = 81.8 bits (193), Expect = 6e-15
Identities = 65/227 (28%), Positives = 104/227 (45%), Gaps = 18/227 (7%)
Query: 30 NIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 89
NI T + + + IG G + C T YA+K +DK K E + +
Sbjct: 481 NIHFT-DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKS--KRDPSEEIEI----- 532
Query: 90 LSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEV 149
L+ G P I+ + + + +++LM GG+L + + F+E E +
Sbjct: 533 --LLRYGQH-PNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTI 589
Query: 150 ILGLEHMHKRHIVYRDLKPANILL-DEHG---HVRISDLGLACDFSKKKP--HASVGTHG 203
++++H + +V+RDLKP+NIL DE G +R+ D G A T
Sbjct: 590 TKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTAN 649
Query: 204 YMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEI 250
++APEVL K GYD++ D +S G +LY +L G +PF EI
Sbjct: 650 FVAPEVL-KRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEI 695
>M63167-1|AAA36539.1| 480|Homo sapiens rac protein kinase-alpha
protein.
Length = 480
Score = 200 bits (489), Expect = 8e-51
Identities = 121/346 (34%), Positives = 186/346 (53%), Gaps = 39/346 (11%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
++TMN+F +++G+G FG+V ++ TG+ YAMK L K+ I K L E +L
Sbjct: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
PF+ + Y+F T D+LCF+++ NGG+L +HLS+ VF+E +FY AE++
Sbjct: 204 ----NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 259
Query: 152 GLEHMH-KRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPE 208
L+++H ++++VYRDLK N++LD+ GH++I+D GL + K GT Y+APE
Sbjct: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319
Query: 209 VLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXX 268
VL + Y + DW+ G ++Y+++ G PF +D ++ ++ L
Sbjct: 320 VL-EDNDYGRAVDWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILM------------ 363
Query: 269 XXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDW 328
E P + P KSLL GLL++D +RLG A E+ +H FFAGI W
Sbjct: 364 ----------EEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVW 413
Query: 329 QQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT-KGIKLTETDQ 373
Q VY +K +PP P D FDEE T + I +T DQ
Sbjct: 414 QHVYEKKLSPPFKP-----QVTSETDTRYFDEEFTAQMITITPPDQ 454
>BC084538-1|AAH84538.1| 480|Homo sapiens v-akt murine thymoma viral
oncogene homolog 1 protein.
Length = 480
Score = 200 bits (489), Expect = 8e-51
Identities = 121/346 (34%), Positives = 186/346 (53%), Gaps = 39/346 (11%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
++TMN+F +++G+G FG+V ++ TG+ YAMK L K+ I K L E +L
Sbjct: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
PF+ + Y+F T D+LCF+++ NGG+L +HLS+ VF+E +FY AE++
Sbjct: 204 ----NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 259
Query: 152 GLEHMH-KRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPE 208
L+++H ++++VYRDLK N++LD+ GH++I+D GL + K GT Y+APE
Sbjct: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319
Query: 209 VLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXX 268
VL + Y + DW+ G ++Y+++ G PF +D ++ ++ L
Sbjct: 320 VL-EDNDYGRAVDWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILM------------ 363
Query: 269 XXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDW 328
E P + P KSLL GLL++D +RLG A E+ +H FFAGI W
Sbjct: 364 ----------EEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVW 413
Query: 329 QQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT-KGIKLTETDQ 373
Q VY +K +PP P D FDEE T + I +T DQ
Sbjct: 414 QHVYEKKLSPPFKP-----QVTSETDTRYFDEEFTAQMITITPPDQ 454
>BC000479-1|AAH00479.1| 480|Homo sapiens v-akt murine thymoma viral
oncogene homolog 1 protein.
Length = 480
Score = 200 bits (489), Expect = 8e-51
Identities = 121/346 (34%), Positives = 186/346 (53%), Gaps = 39/346 (11%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
++TMN+F +++G+G FG+V ++ TG+ YAMK L K+ I K L E +L
Sbjct: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
PF+ + Y+F T D+LCF+++ NGG+L +HLS+ VF+E +FY AE++
Sbjct: 204 ----NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 259
Query: 152 GLEHMH-KRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPE 208
L+++H ++++VYRDLK N++LD+ GH++I+D GL + K GT Y+APE
Sbjct: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319
Query: 209 VLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXX 268
VL + Y + DW+ G ++Y+++ G PF +D ++ ++ L
Sbjct: 320 VL-EDNDYGRAVDWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILM------------ 363
Query: 269 XXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDW 328
E P + P KSLL GLL++D +RLG A E+ +H FFAGI W
Sbjct: 364 ----------EEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVW 413
Query: 329 QQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT-KGIKLTETDQ 373
Q VY +K +PP P D FDEE T + I +T DQ
Sbjct: 414 QHVYEKKLSPPFKP-----QVTSETDTRYFDEEFTAQMITITPPDQ 454
>AF283830-1|AAL55732.1| 480|Homo sapiens AKT1 protein.
Length = 480
Score = 200 bits (489), Expect = 8e-51
Identities = 121/346 (34%), Positives = 186/346 (53%), Gaps = 39/346 (11%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
++TMN+F +++G+G FG+V ++ TG+ YAMK L K+ I K L E +L
Sbjct: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
PF+ + Y+F T D+LCF+++ NGG+L +HLS+ VF+E +FY AE++
Sbjct: 204 ----NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 259
Query: 152 GLEHMH-KRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPE 208
L+++H ++++VYRDLK N++LD+ GH++I+D GL + K GT Y+APE
Sbjct: 260 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 319
Query: 209 VLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXX 268
VL + Y + DW+ G ++Y+++ G PF +D ++ ++ L
Sbjct: 320 VL-EDNDYGRAVDWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILM------------ 363
Query: 269 XXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDW 328
E P + P KSLL GLL++D +RLG A E+ +H FFAGI W
Sbjct: 364 ----------EEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVW 413
Query: 329 QQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT-KGIKLTETDQ 373
Q VY +K +PP P D FDEE T + I +T DQ
Sbjct: 414 QHVYEKKLSPPFKP-----QVTSETDTRYFDEEFTAQMITITPPDQ 454
>M95936-1|AAA58364.1| 481|Homo sapiens protein serine/threonine
kinase protein.
Length = 481
Score = 200 bits (487), Expect = 1e-50
Identities = 122/345 (35%), Positives = 179/345 (51%), Gaps = 38/345 (11%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
++TMNDF +++G+G FG+V R+ TG+ YAMK L K+ I K + E S
Sbjct: 146 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTE----S 201
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
V PF+ + YAF T D+LCF+++ NGG+L +HLS+ VF E +FY AE++
Sbjct: 202 RVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVS 261
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEV 209
LE++H R +VYRD+K N++LD+ GH++I+D GL + GT Y+APEV
Sbjct: 262 ALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEV 321
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
L + Y + DW+ G ++Y+++ G PF +D + ++ L
Sbjct: 322 L-EDNDYGRAVDWWGLGVVMYEMMCGRLPF---YNQDHERLFELILM------------- 364
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
E P + SP KSLL GLL++D +RLG A EV EH FF I+WQ
Sbjct: 365 ---------EEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQ 415
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT-KGIKLTETDQ 373
V +K PP P D FD+E T + I +T D+
Sbjct: 416 DVVQKKLLPPFKP-----QVTSEVDTRYFDDEFTAQSITITPPDR 455
>M77198-1|AAA36585.1| 520|Homo sapiens rac protein kinase-beta
protein.
Length = 520
Score = 200 bits (487), Expect = 1e-50
Identities = 122/345 (35%), Positives = 179/345 (51%), Gaps = 38/345 (11%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
++TMNDF +++G+G FG+V R+ TG+ YAMK L K+ I K + E S
Sbjct: 146 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTE----S 201
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
V PF+ + YAF T D+LCF+++ NGG+L +HLS+ VF E +FY AE++
Sbjct: 202 RVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVS 261
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEV 209
LE++H R +VYRD+K N++LD+ GH++I+D GL + GT Y+APEV
Sbjct: 262 ALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEV 321
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
L + Y + DW+ G ++Y+++ G PF +D + ++ L
Sbjct: 322 L-EDNDYGRAVDWWGLGVVMYEMMCGRLPF---YNQDHERLFELILM------------- 364
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
E P + SP KSLL GLL++D +RLG A EV EH FF I+WQ
Sbjct: 365 ---------EEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQ 415
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT-KGIKLTETDQ 373
V +K PP P D FD+E T + I +T D+
Sbjct: 416 DVVQKKLLPPFKP-----QVTSEVDTRYFDDEFTAQSITITPPDR 455
>BC120994-1|AAI20995.1| 481|Homo sapiens v-akt murine thymoma viral
oncogene homolog 2 protein.
Length = 481
Score = 200 bits (487), Expect = 1e-50
Identities = 122/345 (35%), Positives = 179/345 (51%), Gaps = 38/345 (11%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
++TMNDF +++G+G FG+V R+ TG+ YAMK L K+ I K + E S
Sbjct: 146 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTE----S 201
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
V PF+ + YAF T D+LCF+++ NGG+L +HLS+ VF E +FY AE++
Sbjct: 202 RVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVS 261
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEV 209
LE++H R +VYRD+K N++LD+ GH++I+D GL + GT Y+APEV
Sbjct: 262 ALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEV 321
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
L + Y + DW+ G ++Y+++ G PF +D + ++ L
Sbjct: 322 L-EDNDYGRAVDWWGLGVVMYEMMCGRLPF---YNQDHERLFELILM------------- 364
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
E P + SP KSLL GLL++D +RLG A EV EH FF I+WQ
Sbjct: 365 ---------EEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQ 415
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT-KGIKLTETDQ 373
V +K PP P D FD+E T + I +T D+
Sbjct: 416 DVVQKKLLPPFKP-----QVTSEVDTRYFDDEFTAQSITITPPDR 455
>X61037-1|CAA43372.1| 417|Homo sapiens human protein kinase B
protein.
Length = 417
Score = 189 bits (460), Expect = 3e-47
Identities = 119/346 (34%), Positives = 182/346 (52%), Gaps = 40/346 (11%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
++TMN+F +++G+G FG+V ++ T YAMK L K+ I K L E +
Sbjct: 82 RVTMNEFEYLKLLGKGTFGKVILVKEKATA-YYAMKILKKEVIVAKDEVAHTLTE----N 136
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
V PF+ + Y+F T D+LCF+++ NGG+L +HLS+ VF E +FY AE++
Sbjct: 137 RVQQNSRHPFLTRLKYSFQTHDRLCFVMEYANGGELFFHLSRERVFAEDRARFYGAEIVS 196
Query: 152 GLEHMH-KRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPE 208
L+++H ++++VYRDLK N++LD+ GH++I+D GL + K GT Y+APE
Sbjct: 197 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 256
Query: 209 VLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXX 268
VL + Y + DW+ G ++Y+++ G PF +D ++ ++ L
Sbjct: 257 VL-EDNDYGRAVDWWGLGVVMYEMMCGRLPF---YNQDHEKLFELILM------------ 300
Query: 269 XXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDW 328
E P + P KSLL GLL++D +RLG A E+ +H FF GI W
Sbjct: 301 ----------EEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFTGIVW 350
Query: 329 QQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT-KGIKLTETDQ 373
Q VY +K +PP P D FDEE T + I +T DQ
Sbjct: 351 QHVYEKKLSPPFKP-----QVTSETDTRYFDEEFTAQMITITPPDQ 391
>X06318-1|CAA29634.1| 671|Homo sapiens protein ( Human mRNA for
protein kinase C (PKC) type beta I. ).
Length = 671
Score = 188 bits (459), Expect = 3e-47
Identities = 110/346 (31%), Positives = 185/346 (53%), Gaps = 37/346 (10%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
++ + DF+ ++G+G FG+V + T ++YA+K L K + + E+ +L+
Sbjct: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
L PF+ + F T D+L F+++ +NGGDL YH+ Q G F E FYAAE+ +
Sbjct: 396 LPGKP---PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI 452
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEV 209
GL + + I+YRDLK N++LD GH++I+D G+ + + GT Y+APE+
Sbjct: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
++ Y S DW++FG +LY++L G +PF + +D+ E+ +
Sbjct: 513 IAY-QPYGKSVDWWAFGVLLYEMLAGQAPF---EGEDEDELFQ----------------- 551
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
++ EH P+S S ++ +GL+ + KRLGC G ++KEH FF IDW+
Sbjct: 552 -----SIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWE 606
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTK-GIKLTETDQM 374
++ ++ PP P A D D +FD+E T+ ++LT TD++
Sbjct: 607 KLERKEIQPPYKP-----KARDKRDTSNFDKEFTRQPVELTPTDKL 647
>AC002299-1|AAB97933.1| 494|Homo sapiens Protein kinase C beta (5'
partial) splice form_1 protein.
Length = 494
Score = 188 bits (459), Expect = 3e-47
Identities = 110/346 (31%), Positives = 185/346 (53%), Gaps = 37/346 (10%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
++ + DF+ ++G+G FG+V + T ++YA+K L K + + E+ +L+
Sbjct: 159 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 218
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
L PF+ + F T D+L F+++ +NGGDL YH+ Q G F E FYAAE+ +
Sbjct: 219 LPGKP---PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI 275
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEV 209
GL + + I+YRDLK N++LD GH++I+D G+ + + GT Y+APE+
Sbjct: 276 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 335
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
++ Y S DW++FG +LY++L G +PF + +D+ E+ +
Sbjct: 336 IAY-QPYGKSVDWWAFGVLLYEMLAGQAPF---EGEDEDELFQ----------------- 374
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
++ EH P+S S ++ +GL+ + KRLGC G ++KEH FF IDW+
Sbjct: 375 -----SIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWE 429
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDTK-GIKLTETDQM 374
++ ++ PP P A D D +FD+E T+ ++LT TD++
Sbjct: 430 KLERKEIQPPYKP-----KARDKRDTSNFDKEFTRQPVELTPTDKL 470
>AY633609-1|AAV33302.1| 672|Homo sapiens aging-associated gene 6
protein protein.
Length = 672
Score = 186 bits (453), Expect = 2e-46
Identities = 111/356 (31%), Positives = 182/356 (51%), Gaps = 34/356 (9%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
++ + DF+ ++G+G FG+V + T ++YA+K L K + + E+ +L+
Sbjct: 333 RVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLA 392
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
L+ PF+ + F T D+L F+++ +NGGDL YH+ Q G F E + FYAAE+ +
Sbjct: 393 LLDKP---PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISI 449
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEV 209
GL +HKR I+YRDLK N++LD GH++I+D G+ + GT Y+APE+
Sbjct: 450 GLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEI 509
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
++ Y S DW+++G +LY++L G PF D + D++ +++
Sbjct: 510 IAY-QPYGKSVDWWAYGVLLYEMLAGQPPF------DGEDEDELFQSIM----------- 551
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
EH P+S S S+ +GL+ + KRLGC G +V+EH FF IDW+
Sbjct: 552 --------EHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWE 603
Query: 330 QVYHQKYTPPLIPP---RGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDFPLV 382
++ +++ PP P +G N F G + + DQ Y+ F V
Sbjct: 604 KLENREIQPPFKPKVRGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDYEGFSYV 659
>X52479-1|CAA36718.1| 672|Homo sapiens protein ( Human PKC alpha
mRNA for protein kinase C alpha. ).
Length = 672
Score = 185 bits (450), Expect = 4e-46
Identities = 110/356 (30%), Positives = 182/356 (51%), Gaps = 34/356 (9%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
++ + DF+ ++G+G FG+V + T ++YA+K L K + + E+ +L+
Sbjct: 333 RVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLA 392
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
L+ PF+ + F T D+L F+++ +NGGDL YH+ Q G F E + FYAAE+ +
Sbjct: 393 LLDKP---PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISI 449
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEV 209
GL +HKR I+YRDLK N++LD GH++I+D G+ + GT Y+APE+
Sbjct: 450 GLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEI 509
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
++ Y S DW+++G +LY++L G PF D + D++ +++
Sbjct: 510 IAY-QPYGKSVDWWAYGVLLYEMLAGQPPF------DGEDEDELFQSIM----------- 551
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
EH P+S S S+ +GL+ + KRLGC G +V+EH FF IDW+
Sbjct: 552 --------EHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWE 603
Query: 330 QVYHQKYTPPLIPP---RGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDFPLV 382
++ +++ PP P +G N F G + + DQ ++ F V
Sbjct: 604 KLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYV 659
>BC109274-1|AAI09275.1| 672|Homo sapiens protein kinase C, alpha
protein.
Length = 672
Score = 185 bits (450), Expect = 4e-46
Identities = 110/356 (30%), Positives = 182/356 (51%), Gaps = 34/356 (9%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
++ + DF+ ++G+G FG+V + T ++YA+K L K + + E+ +L+
Sbjct: 333 RVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLA 392
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
L+ PF+ + F T D+L F+++ +NGGDL YH+ Q G F E + FYAAE+ +
Sbjct: 393 LLDKP---PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISI 449
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEV 209
GL +HKR I+YRDLK N++LD GH++I+D G+ + GT Y+APE+
Sbjct: 450 GLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEI 509
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
++ Y S DW+++G +LY++L G PF D + D++ +++
Sbjct: 510 IAY-QPYGKSVDWWAYGVLLYEMLAGQPPF------DGEDEDELFQSIM----------- 551
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
EH P+S S S+ +GL+ + KRLGC G +V+EH FF IDW+
Sbjct: 552 --------EHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWE 603
Query: 330 QVYHQKYTPPLIPP---RGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDFPLV 382
++ +++ PP P +G N F G + + DQ ++ F V
Sbjct: 604 KLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYV 659
>BC109273-1|AAI09274.1| 672|Homo sapiens protein kinase C, alpha
protein.
Length = 672
Score = 185 bits (450), Expect = 4e-46
Identities = 110/356 (30%), Positives = 182/356 (51%), Gaps = 34/356 (9%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
++ + DF+ ++G+G FG+V + T ++YA+K L K + + E+ +L+
Sbjct: 333 RVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLA 392
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
L+ PF+ + F T D+L F+++ +NGGDL YH+ Q G F E + FYAAE+ +
Sbjct: 393 LLDKP---PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISI 449
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEV 209
GL +HKR I+YRDLK N++LD GH++I+D G+ + GT Y+APE+
Sbjct: 450 GLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEI 509
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
++ Y S DW+++G +LY++L G PF D + D++ +++
Sbjct: 510 IAY-QPYGKSVDWWAYGVLLYEMLAGQPPF------DGEDEDELFQSIM----------- 551
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
EH P+S S S+ +GL+ + KRLGC G +V+EH FF IDW+
Sbjct: 552 --------EHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWE 603
Query: 330 QVYHQKYTPPLIPP---RGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDFPLV 382
++ +++ PP P +G N F G + + DQ ++ F V
Sbjct: 604 KLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYV 659
>Z84486-1|CAI21678.1| 526|Homo sapiens serum/glucocorticoid
regulated kinase protein.
Length = 526
Score = 181 bits (441), Expect = 5e-45
Identities = 120/332 (36%), Positives = 173/332 (52%), Gaps = 39/332 (11%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 95
+DF ++IG+G FG+V R YA+K L KK I K+ E ++ER +++
Sbjct: 191 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSER---NVLLK 247
Query: 96 GVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEH 155
V PF+V + ++F T DKL F+LD +NGG+L YHL + F E +FYAAE+ L +
Sbjct: 248 NVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGY 307
Query: 156 MHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKG 213
+H +IVYRDLKP NILLD GH+ ++D GL + + S GT Y+APEVL K
Sbjct: 308 LHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHK- 366
Query: 214 TGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHE-IDKMTLTMLRNXXXXXXXXXXXA 272
YD + DW+ G +LY++L G PF T + ++ I L + N
Sbjct: 367 QPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPN------------ 414
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+ S L+ LL+ +D KRLG K E+K HVFF+ I+W +
Sbjct: 415 ----------ITNSARHLLEGLLQ----KDRTKRLGAKD-DFMEIKSHVFFSLINWDDLI 459
Query: 333 HQKYTPPLIPPRGEVNAADAFDIGSFDEEDTK 364
++K TPP P N + D+ FD E T+
Sbjct: 460 NKKITPPFNP-----NVSGPNDLRHFDPEFTE 486
>BC001263-1|AAH01263.1| 431|Homo sapiens serum/glucocorticoid
regulated kinase protein.
Length = 431
Score = 181 bits (441), Expect = 5e-45
Identities = 120/332 (36%), Positives = 173/332 (52%), Gaps = 39/332 (11%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 95
+DF ++IG+G FG+V R YA+K L KK I K+ E ++ER +++
Sbjct: 96 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSER---NVLLK 152
Query: 96 GVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEH 155
V PF+V + ++F T DKL F+LD +NGG+L YHL + F E +FYAAE+ L +
Sbjct: 153 NVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGY 212
Query: 156 MHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKG 213
+H +IVYRDLKP NILLD GH+ ++D GL + + S GT Y+APEVL K
Sbjct: 213 LHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHK- 271
Query: 214 TGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHE-IDKMTLTMLRNXXXXXXXXXXXA 272
YD + DW+ G +LY++L G PF T + ++ I L + N
Sbjct: 272 QPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPN------------ 319
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+ S L+ LL+ +D KRLG K E+K HVFF+ I+W +
Sbjct: 320 ----------ITNSARHLLEGLLQ----KDRTKRLGAKD-DFMEIKSHVFFSLINWDDLI 364
Query: 333 HQKYTPPLIPPRGEVNAADAFDIGSFDEEDTK 364
++K TPP P N + D+ FD E T+
Sbjct: 365 NKKITPPFNP-----NVSGPNDLRHFDPEFTE 391
>AL355881-2|CAH72579.1| 526|Homo sapiens serum/glucocorticoid
regulated kinase protein.
Length = 526
Score = 181 bits (441), Expect = 5e-45
Identities = 120/332 (36%), Positives = 173/332 (52%), Gaps = 39/332 (11%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 95
+DF ++IG+G FG+V R YA+K L KK I K+ E ++ER +++
Sbjct: 191 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSER---NVLLK 247
Query: 96 GVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEH 155
V PF+V + ++F T DKL F+LD +NGG+L YHL + F E +FYAAE+ L +
Sbjct: 248 NVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGY 307
Query: 156 MHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKG 213
+H +IVYRDLKP NILLD GH+ ++D GL + + S GT Y+APEVL K
Sbjct: 308 LHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHK- 366
Query: 214 TGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHE-IDKMTLTMLRNXXXXXXXXXXXA 272
YD + DW+ G +LY++L G PF T + ++ I L + N
Sbjct: 367 QPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPN------------ 414
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+ S L+ LL+ +D KRLG K E+K HVFF+ I+W +
Sbjct: 415 ----------ITNSARHLLEGLLQ----KDRTKRLGAKD-DFMEIKSHVFFSLINWDDLI 459
Query: 333 HQKYTPPLIPPRGEVNAADAFDIGSFDEEDTK 364
++K TPP P N + D+ FD E T+
Sbjct: 460 NKKITPPFNP-----NVSGPNDLRHFDPEFTE 486
>AL135839-4|CAI19721.1| 526|Homo sapiens serum/glucocorticoid
regulated kinase protein.
Length = 526
Score = 181 bits (441), Expect = 5e-45
Identities = 120/332 (36%), Positives = 173/332 (52%), Gaps = 39/332 (11%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 95
+DF ++IG+G FG+V R YA+K L KK I K+ E ++ER +++
Sbjct: 191 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSER---NVLLK 247
Query: 96 GVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEH 155
V PF+V + ++F T DKL F+LD +NGG+L YHL + F E +FYAAE+ L +
Sbjct: 248 NVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGY 307
Query: 156 MHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKG 213
+H +IVYRDLKP NILLD GH+ ++D GL + + S GT Y+APEVL K
Sbjct: 308 LHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHK- 366
Query: 214 TGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHE-IDKMTLTMLRNXXXXXXXXXXXA 272
YD + DW+ G +LY++L G PF T + ++ I L + N
Sbjct: 367 QPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPN------------ 414
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+ S L+ LL+ +D KRLG K E+K HVFF+ I+W +
Sbjct: 415 ----------ITNSARHLLEGLLQ----KDRTKRLGAKD-DFMEIKSHVFFSLINWDDLI 459
Query: 333 HQKYTPPLIPPRGEVNAADAFDIGSFDEEDTK 364
++K TPP P N + D+ FD E T+
Sbjct: 460 NKKITPPFNP-----NVSGPNDLRHFDPEFTE 486
>AL135839-3|CAI19720.1| 445|Homo sapiens serum/glucocorticoid
regulated kinase protein.
Length = 445
Score = 181 bits (441), Expect = 5e-45
Identities = 120/332 (36%), Positives = 173/332 (52%), Gaps = 39/332 (11%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 95
+DF ++IG+G FG+V R YA+K L KK I K+ E ++ER +++
Sbjct: 110 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSER---NVLLK 166
Query: 96 GVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEH 155
V PF+V + ++F T DKL F+LD +NGG+L YHL + F E +FYAAE+ L +
Sbjct: 167 NVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGY 226
Query: 156 MHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKG 213
+H +IVYRDLKP NILLD GH+ ++D GL + + S GT Y+APEVL K
Sbjct: 227 LHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHK- 285
Query: 214 TGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHE-IDKMTLTMLRNXXXXXXXXXXXA 272
YD + DW+ G +LY++L G PF T + ++ I L + N
Sbjct: 286 QPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPN------------ 333
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+ S L+ LL+ +D KRLG K E+K HVFF+ I+W +
Sbjct: 334 ----------ITNSARHLLEGLLQ----KDRTKRLGAKD-DFMEIKSHVFFSLINWDDLI 378
Query: 333 HQKYTPPLIPPRGEVNAADAFDIGSFDEEDTK 364
++K TPP P N + D+ FD E T+
Sbjct: 379 NKKITPPFNP-----NVSGPNDLRHFDPEFTE 405
>AL135839-2|CAI19719.1| 431|Homo sapiens serum/glucocorticoid
regulated kinase protein.
Length = 431
Score = 181 bits (441), Expect = 5e-45
Identities = 120/332 (36%), Positives = 173/332 (52%), Gaps = 39/332 (11%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 95
+DF ++IG+G FG+V R YA+K L KK I K+ E ++ER +++
Sbjct: 96 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSER---NVLLK 152
Query: 96 GVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEH 155
V PF+V + ++F T DKL F+LD +NGG+L YHL + F E +FYAAE+ L +
Sbjct: 153 NVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGY 212
Query: 156 MHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKG 213
+H +IVYRDLKP NILLD GH+ ++D GL + + S GT Y+APEVL K
Sbjct: 213 LHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHK- 271
Query: 214 TGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHE-IDKMTLTMLRNXXXXXXXXXXXA 272
YD + DW+ G +LY++L G PF T + ++ I L + N
Sbjct: 272 QPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPN------------ 319
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+ S L+ LL+ +D KRLG K E+K HVFF+ I+W +
Sbjct: 320 ----------ITNSARHLLEGLLQ----KDRTKRLGAKD-DFMEIKSHVFFSLINWDDLI 364
Query: 333 HQKYTPPLIPPRGEVNAADAFDIGSFDEEDTK 364
++K TPP P N + D+ FD E T+
Sbjct: 365 NKKITPPFNP-----NVSGPNDLRHFDPEFTE 391
>AL135839-1|CAI19718.1| 421|Homo sapiens serum/glucocorticoid
regulated kinase protein.
Length = 421
Score = 181 bits (441), Expect = 5e-45
Identities = 120/332 (36%), Positives = 173/332 (52%), Gaps = 39/332 (11%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 95
+DF ++IG+G FG+V R YA+K L KK I K+ E ++ER +++
Sbjct: 86 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSER---NVLLK 142
Query: 96 GVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEH 155
V PF+V + ++F T DKL F+LD +NGG+L YHL + F E +FYAAE+ L +
Sbjct: 143 NVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGY 202
Query: 156 MHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKG 213
+H +IVYRDLKP NILLD GH+ ++D GL + + S GT Y+APEVL K
Sbjct: 203 LHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHK- 261
Query: 214 TGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHE-IDKMTLTMLRNXXXXXXXXXXXA 272
YD + DW+ G +LY++L G PF T + ++ I L + N
Sbjct: 262 QPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPN------------ 309
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+ S L+ LL+ +D KRLG K E+K HVFF+ I+W +
Sbjct: 310 ----------ITNSARHLLEGLLQ----KDRTKRLGAKD-DFMEIKSHVFFSLINWDDLI 354
Query: 333 HQKYTPPLIPPRGEVNAADAFDIGSFDEEDTK 364
++K TPP P N + D+ FD E T+
Sbjct: 355 NKKITPPFNP-----NVSGPNDLRHFDPEFTE 381
>AF153609-1|AAD41091.1| 431|Homo sapiens serine/threonine protein
kinase sgk protein.
Length = 431
Score = 181 bits (441), Expect = 5e-45
Identities = 120/332 (36%), Positives = 173/332 (52%), Gaps = 39/332 (11%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 95
+DF ++IG+G FG+V R YA+K L KK I K+ E ++ER +++
Sbjct: 96 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSER---NVLLK 152
Query: 96 GVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEH 155
V PF+V + ++F T DKL F+LD +NGG+L YHL + F E +FYAAE+ L +
Sbjct: 153 NVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGY 212
Query: 156 MHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKG 213
+H +IVYRDLKP NILLD GH+ ++D GL + + S GT Y+APEVL K
Sbjct: 213 LHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHK- 271
Query: 214 TGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHE-IDKMTLTMLRNXXXXXXXXXXXA 272
YD + DW+ G +LY++L G PF T + ++ I L + N
Sbjct: 272 QPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPN------------ 319
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+ S L+ LL+ +D KRLG K E+K HVFF+ I+W +
Sbjct: 320 ----------ITNSARHLLEGLLQ----KDRTKRLGAKD-DFMEIKSHVFFSLINWDDLI 364
Query: 333 HQKYTPPLIPPRGEVNAADAFDIGSFDEEDTK 364
++K TPP P N + D+ FD E T+
Sbjct: 365 NKKITPPFNP-----NVSGPNDLRHFDPEFTE 391
>Y10032-1|CAA71138.1| 431|Homo sapiens serine/threonine protein
kinase protein.
Length = 431
Score = 180 bits (439), Expect = 9e-45
Identities = 120/329 (36%), Positives = 170/329 (51%), Gaps = 35/329 (10%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 95
+DF ++IG+G FG+V R YA+K L KK I K+ E ++ER +++
Sbjct: 96 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSER---NVLLK 152
Query: 96 GVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEH 155
V PF+V + ++F T DKL F+LD +NGG+L YHL + F E +FYAAE+ L +
Sbjct: 153 NVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGY 212
Query: 156 MHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKG 213
+H +IVYRDLKP NILLD GH+ ++D GL + + S GT Y+APEVL K
Sbjct: 213 LHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHK- 271
Query: 214 TGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHE-IDKMTLTMLRNXXXXXXXXXXXA 272
YD + DW+ G +LY++L G PF T + ++ I L + N
Sbjct: 272 QPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPN------------ 319
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+ S L+ LL+ +D KRLG K E+K HVFF+ I+W +
Sbjct: 320 ----------ITNSARHLLEGLLQ----KDRTKRLGAKD-DFMEIKSHVFFSLINWDDLI 364
Query: 333 HQKYTPPLIPPRGEVNAADAFDIGSFDEE 361
++K TPP P N FD F EE
Sbjct: 365 NKKITPPFNPNVSGPNELRHFD-PEFTEE 392
>AJ000512-1|CAA04146.1| 431|Homo sapiens serine/threonine protein
kinase protein.
Length = 431
Score = 180 bits (439), Expect = 9e-45
Identities = 120/329 (36%), Positives = 170/329 (51%), Gaps = 35/329 (10%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 95
+DF ++IG+G FG+V R YA+K L KK I K+ E ++ER +++
Sbjct: 96 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSER---NVLLK 152
Query: 96 GVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEH 155
V PF+V + ++F T DKL F+LD +NGG+L YHL + F E +FYAAE+ L +
Sbjct: 153 NVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGY 212
Query: 156 MHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKG 213
+H +IVYRDLKP NILLD GH+ ++D GL + + S GT Y+APEVL K
Sbjct: 213 LHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHK- 271
Query: 214 TGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHE-IDKMTLTMLRNXXXXXXXXXXXA 272
YD + DW+ G +LY++L G PF T + ++ I L + N
Sbjct: 272 QPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPN------------ 319
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+ S L+ LL+ +D KRLG K E+K HVFF+ I+W +
Sbjct: 320 ----------ITNSARHLLEGLLQ----KDRTKRLGAKD-DFMEIKSHVFFSLINWDDLI 364
Query: 333 HQKYTPPLIPPRGEVNAADAFDIGSFDEE 361
++K TPP P N FD F EE
Sbjct: 365 NKKITPPFNPNVSGPNELRHFD-PEFTEE 392
>X07109-1|CAA30130.1| 673|Homo sapiens protein ( Human mRNA for
protein kinase C (PKC) type beta II. ).
Length = 673
Score = 178 bits (433), Expect = 5e-44
Identities = 103/325 (31%), Positives = 172/325 (52%), Gaps = 32/325 (9%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
++ + DF+ ++G+G FG+V + T ++YA+K L K + + E+ +L+
Sbjct: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
L PF+ + F T D+L F+++ +NGGDL YH+ Q G F E FYAAE+ +
Sbjct: 396 LPGKP---PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI 452
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEV 209
GL + + I+YRDLK N++LD GH++I+D G+ + + GT Y+APE+
Sbjct: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
++ Y S DW++FG +LY++L G +PF + +D+ E+ +
Sbjct: 513 IAY-QPYGKSVDWWAFGVLLYEMLAGQAPF---EGEDEDELFQ----------------- 551
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
++ EH P+S S ++ +GL+ + KRLGC G ++KEH FF IDW+
Sbjct: 552 -----SIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWE 606
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFD 354
++ ++ PP P N A+ FD
Sbjct: 607 KLERKEIQPPYKPKACGRN-AENFD 630
>M13975-1|AAA60095.1| 673|Homo sapiens protein kinase C beta-II
type protein.
Length = 673
Score = 178 bits (433), Expect = 5e-44
Identities = 103/325 (31%), Positives = 172/325 (52%), Gaps = 32/325 (9%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
++ + DF+ ++G+G FG+V + T ++YA+K L K + + E+ +L+
Sbjct: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
L PF+ + F T D+L F+++ +NGGDL YH+ Q G F E FYAAE+ +
Sbjct: 396 LPGKP---PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI 452
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEV 209
GL + + I+YRDLK N++LD GH++I+D G+ + + GT Y+APE+
Sbjct: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
++ Y S DW++FG +LY++L G +PF + +D+ E+ +
Sbjct: 513 IAY-QPYGKSVDWWAFGVLLYEMLAGQAPF---EGEDEDELFQ----------------- 551
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
++ EH P+S S ++ +GL+ + KRLGC G ++KEH FF IDW+
Sbjct: 552 -----SIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWE 606
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFD 354
++ ++ PP P N A+ FD
Sbjct: 607 KLERKEIQPPYKPKACGRN-AENFD 630
>BC036472-1|AAH36472.1| 673|Homo sapiens protein kinase C, beta 1
protein.
Length = 673
Score = 178 bits (433), Expect = 5e-44
Identities = 103/325 (31%), Positives = 172/325 (52%), Gaps = 32/325 (9%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
++ + DF+ ++G+G FG+V + T ++YA+K L K + + E+ +L+
Sbjct: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
L PF+ + F T D+L F+++ +NGGDL YH+ Q G F E FYAAE+ +
Sbjct: 396 LPGKP---PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI 452
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEV 209
GL + + I+YRDLK N++LD GH++I+D G+ + + GT Y+APE+
Sbjct: 453 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
++ Y S DW++FG +LY++L G +PF + +D+ E+ +
Sbjct: 513 IAY-QPYGKSVDWWAFGVLLYEMLAGQAPF---EGEDEDELFQ----------------- 551
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
++ EH P+S S ++ +GL+ + KRLGC G ++KEH FF IDW+
Sbjct: 552 -----SIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWE 606
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFD 354
++ ++ PP P N A+ FD
Sbjct: 607 KLERKEIQPPYKPKACGRN-AENFD 630
>AC002299-2|AAB97934.1| 496|Homo sapiens Protein kinase C beta (5'
partial) splice form_ protein.
Length = 496
Score = 178 bits (433), Expect = 5e-44
Identities = 103/325 (31%), Positives = 172/325 (52%), Gaps = 32/325 (9%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
++ + DF+ ++G+G FG+V + T ++YA+K L K + + E+ +L+
Sbjct: 159 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 218
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
L PF+ + F T D+L F+++ +NGGDL YH+ Q G F E FYAAE+ +
Sbjct: 219 LPGKP---PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAI 275
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEV 209
GL + + I+YRDLK N++LD GH++I+D G+ + + GT Y+APE+
Sbjct: 276 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 335
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
++ Y S DW++FG +LY++L G +PF + +D+ E+ +
Sbjct: 336 IAY-QPYGKSVDWWAFGVLLYEMLAGQAPF---EGEDEDELFQ----------------- 374
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
++ EH P+S S ++ +GL+ + KRLGC G ++KEH FF IDW+
Sbjct: 375 -----SIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWE 429
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFD 354
++ ++ PP P N A+ FD
Sbjct: 430 KLERKEIQPPYKPKACGRN-AENFD 453
>M60725-1|AAA36411.1| 502|Homo sapiens p70 ribosomal S6 kinase
alpha-II protein.
Length = 502
Score = 177 bits (431), Expect = 9e-44
Identities = 111/311 (35%), Positives = 165/311 (53%), Gaps = 36/311 (11%)
Query: 38 FSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALN-ERIMLSLV 93
F + R++G+GG+G+V+ RK A+TGK++AMK L K I +T ER +L V
Sbjct: 68 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 127
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
PFIV + YAF T KL IL+ ++GG+L L + G+F E FY AE+ + L
Sbjct: 128 KH----PFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMAL 183
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLS 211
H+H++ I+YRDLKP NI+L+ GHV+++D GL + H GT YMAPE+L
Sbjct: 184 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 243
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXX 271
+ +G++ + DW+S G ++Y +L G PF K IDK+ L
Sbjct: 244 R-SGHNRAVDWWSLGALMYDMLTGAPPFTGENR--KKTIDKILKCKL------------- 287
Query: 272 ASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQV 331
+P + + LL+ LL+R+ RLG A EV+ H FF I+W+++
Sbjct: 288 ----------NLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL 337
Query: 332 YHQKYTPPLIP 342
+K PP P
Sbjct: 338 LARKVEPPFKP 348
>M60724-1|AAA36410.1| 525|Homo sapiens p70 ribosomal S6 kinase
alpha-I protein.
Length = 525
Score = 177 bits (431), Expect = 9e-44
Identities = 111/311 (35%), Positives = 165/311 (53%), Gaps = 36/311 (11%)
Query: 38 FSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALN-ERIMLSLV 93
F + R++G+GG+G+V+ RK A+TGK++AMK L K I +T ER +L V
Sbjct: 91 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 150
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
PFIV + YAF T KL IL+ ++GG+L L + G+F E FY AE+ + L
Sbjct: 151 KH----PFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMAL 206
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLS 211
H+H++ I+YRDLKP NI+L+ GHV+++D GL + H GT YMAPE+L
Sbjct: 207 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 266
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXX 271
+ +G++ + DW+S G ++Y +L G PF K IDK+ L
Sbjct: 267 R-SGHNRAVDWWSLGALMYDMLTGAPPFTGENR--KKTIDKILKCKL------------- 310
Query: 272 ASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQV 331
+P + + LL+ LL+R+ RLG A EV+ H FF I+W+++
Sbjct: 311 ----------NLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL 360
Query: 332 YHQKYTPPLIP 342
+K PP P
Sbjct: 361 LARKVEPPFKP 371
>BC053365-1|AAH53365.1| 451|Homo sapiens RPS6KB1 protein protein.
Length = 451
Score = 177 bits (431), Expect = 9e-44
Identities = 111/311 (35%), Positives = 165/311 (53%), Gaps = 36/311 (11%)
Query: 38 FSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALN-ERIMLSLV 93
F + R++G+GG+G+V+ RK A+TGK++AMK L K I +T ER +L V
Sbjct: 91 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 150
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
PFIV + YAF T KL IL+ ++GG+L L + G+F E FY AE+ + L
Sbjct: 151 KH----PFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMAL 206
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLS 211
H+H++ I+YRDLKP NI+L+ GHV+++D GL + H GT YMAPE+L
Sbjct: 207 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 266
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXX 271
+ +G++ + DW+S G ++Y +L G PF K IDK+ L
Sbjct: 267 R-SGHNRAVDWWSLGALMYDMLTGAPPFTGENR--KKTIDKILKCKL------------- 310
Query: 272 ASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQV 331
+P + + LL+ LL+R+ RLG A EV+ H FF I+W+++
Sbjct: 311 ----------NLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL 360
Query: 332 YHQKYTPPLIP 342
+K PP P
Sbjct: 361 LARKVEPPFKP 371
>L33881-1|AAB17011.1| 587|Homo sapiens protein kinase C iota
protein.
Length = 587
Score = 175 bits (425), Expect = 5e-43
Identities = 105/344 (30%), Positives = 178/344 (51%), Gaps = 29/344 (8%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
L + DF + R+IGRG + +V R T ++YAMK + K+ + + E+ +
Sbjct: 240 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQ 299
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
S PF+V + F T +L F+++ +NGGDL +H+ + E +FY+AE+ L
Sbjct: 300 ASNH---PFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLA 356
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVL 210
L ++H+R I+YRDLK N+LLD GH++++D G+ + + S GT Y+APE+L
Sbjct: 357 LNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEIL 416
Query: 211 SKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXX 270
+G Y S DW++ G ++++++ G SPF + D D+ T L
Sbjct: 417 -RGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNP--DQNTEDYL------------ 461
Query: 271 XASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGR-GADEVKEHVFFAGIDWQ 329
+ E + +P S S S+L+ L +D +RLGC + G +++ H FF +DW
Sbjct: 462 --FQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWD 519
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT-KGIKLTETD 372
+ ++ PP P N + F + +FD + T + ++LT D
Sbjct: 520 MMEQKQVVPPFKP-----NISGEFGLDNFDSQFTNEPVQLTPDD 558
>L18964-1|AAA60171.1| 587|Homo sapiens protein kinase C iota
protein.
Length = 587
Score = 175 bits (425), Expect = 5e-43
Identities = 105/344 (30%), Positives = 178/344 (51%), Gaps = 29/344 (8%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
L + DF + R+IGRG + +V R T ++YAMK + K+ + + E+ +
Sbjct: 240 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQ 299
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
S PF+V + F T +L F+++ +NGGDL +H+ + E +FY+AE+ L
Sbjct: 300 ASNH---PFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLA 356
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVL 210
L ++H+R I+YRDLK N+LLD GH++++D G+ + + S GT Y+APE+L
Sbjct: 357 LNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEIL 416
Query: 211 SKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXX 270
+G Y S DW++ G ++++++ G SPF + D D+ T L
Sbjct: 417 -RGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNP--DQNTEDYL------------ 461
Query: 271 XASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGR-GADEVKEHVFFAGIDWQ 329
+ E + +P S S S+L+ L +D +RLGC + G +++ H FF +DW
Sbjct: 462 --FQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWD 519
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT-KGIKLTETD 372
+ ++ PP P N + F + +FD + T + ++LT D
Sbjct: 520 MMEQKQVVPPFKP-----NISGEFGLDNFDSQFTNEPVQLTPDD 558
>BC022016-1|AAH22016.3| 587|Homo sapiens protein kinase C, iota
protein.
Length = 587
Score = 174 bits (424), Expect = 6e-43
Identities = 105/344 (30%), Positives = 178/344 (51%), Gaps = 29/344 (8%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
L + DF + R+IGRG + +V R T ++YAMK + K+ + + E+ +
Sbjct: 240 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQ 299
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
S PF+V + F T +L F+++ +NGGDL +H+ + E +FY+AE+ L
Sbjct: 300 ASNH---PFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLA 356
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVL 210
L ++H+R I+YRDLK N+LLD GH++++D G+ + + S GT Y+APE+L
Sbjct: 357 LNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEIL 416
Query: 211 SKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXX 270
+G Y S DW++ G ++++++ G SPF + D D+ T L
Sbjct: 417 -RGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNP--DQNTEDYL------------ 461
Query: 271 XASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGR-GADEVKEHVFFAGIDWQ 329
+ E + +P S S S+L+ L +D +RLGC + G +++ H FF +DW
Sbjct: 462 --FQVILEKQIRIPRSMSVKAASVLKSFLNKDPKERLGCLPQTGFADIQGHPFFRNVDWD 519
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT-KGIKLTETD 372
+ ++ PP P N + F + +FD + T + ++LT D
Sbjct: 520 MMEQKQVVPPFKP-----NISGEFGLDNFDSQFTNERVQLTPDD 558
>AJ250839-1|CAB76471.1| 414|Homo sapiens serine/threonine protein
kinase protein.
Length = 414
Score = 171 bits (417), Expect = 4e-42
Identities = 104/331 (31%), Positives = 171/331 (51%), Gaps = 35/331 (10%)
Query: 30 NIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 89
N ++ + F + R IG+G FG+V +K DT KMYAMK ++K++ +++ E + +
Sbjct: 15 NEEVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKC-IERDEVRNVFRELQ 73
Query: 90 LSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEV 149
+ G++ PF+V + Y+F + + ++DL+ GGDL YHL Q+ F E +K Y E+
Sbjct: 74 ---IMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICEL 130
Query: 150 ILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF-SKKKPHASVGTHGYMAPE 208
L LE++ + HI++RD+KP NILLDEHGHV I+D +A ++ + GT YMAPE
Sbjct: 131 ALALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSMAGTKPYMAPE 190
Query: 209 V----LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXX 264
V + +G GY DW+S G Y+LL+G P+ H EI L M +
Sbjct: 191 VFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEI----LNMFK----- 241
Query: 265 XXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFA 324
+ST + + +LL LL +D R+ +++ + A
Sbjct: 242 -VERVHYSST------------WCKGMVALLRKLLTKDPESRVS----SLHDIQSVPYLA 284
Query: 325 GIDWQQVYHQKYTPPLIPPRGEVNAADAFDI 355
++W V+ + P +P +G +N F++
Sbjct: 285 DMNWDAVFKKALMPGFVPNKGRLNCDPTFEL 315
>AB019245-1|BAA37145.1| 481|Homo sapiens S6 kinase b protein.
Length = 481
Score = 170 bits (414), Expect = 1e-41
Identities = 105/310 (33%), Positives = 163/310 (52%), Gaps = 35/310 (11%)
Query: 38 FSVHRIIGRGGFGEVYGCRKA--DTGKMYAMKCLDKKRIKMKQGETLALN-ERIMLSLVS 94
F + R++G+GG+G+V+ RK + GK+YAMK L K +I +T ER +L V
Sbjct: 67 FELLRVLGKGGYGKVFQVRKVQGNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVK 126
Query: 95 TGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLE 154
PFIV + YAF T KL IL+ ++GG+L HL + G+F E FY AE+ L L
Sbjct: 127 H----PFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALG 182
Query: 155 HMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP--HASVGTHGYMAPEVLSK 212
H+H + I+YRDLKP NI+L GH++++D GL + + H GT YMAPE+L +
Sbjct: 183 HLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVR 242
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXA 272
+G++ + DW+S G ++Y +L G PF K +DK+ L
Sbjct: 243 -SGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKT--MDKIIRGKL-------------- 285
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+P +P + L++ L+R+ ++R+G A +V+ H FF ++W +
Sbjct: 286 ---------ALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLL 336
Query: 333 HQKYTPPLIP 342
+ PP P
Sbjct: 337 AWRVDPPFRP 346
>BC040061-1|AAH40061.1| 942|Homo sapiens protein kinase N1 protein.
Length = 942
Score = 170 bits (413), Expect = 1e-41
Identities = 111/334 (33%), Positives = 174/334 (52%), Gaps = 37/334 (11%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK-QGETLALNERIMLS 91
LT+ DF ++GRG FG+V +G+++A+K L K I + + E+L +RI+ +
Sbjct: 610 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 669
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
+ S G PF+V + F TP+ +CF+++ GGDL H+ VF+E FY+A V+L
Sbjct: 670 VTSAGH--PFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVL 726
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEV 209
GL+ +H+ IVYRDLK N+LLD G+V+I+D GL + S GT ++APEV
Sbjct: 727 GLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 786
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
L+ T Y + DW+ G +LY++L G SPF D+ E+
Sbjct: 787 LT-DTSYTRAVDWWGLGVLLYEMLVGESPF---PGDDEEEV------------------- 823
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
++ E P S ++ LL+R+ +RLG R A++VK+ FF + W+
Sbjct: 824 ---FDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWE 880
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT 363
+ ++ PP +P + DI +FDEE T
Sbjct: 881 ALLARRLPPPFVP-----TLSGRTDISNFDEEFT 909
>BC038238-1|AAH38238.1| 414|Homo sapiens serine/threonine kinase
32B protein.
Length = 414
Score = 170 bits (413), Expect = 1e-41
Identities = 104/331 (31%), Positives = 170/331 (51%), Gaps = 35/331 (10%)
Query: 30 NIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 89
N ++ + F + R IG+G FG+V +K DT KMYAMK ++K++ +++ E + +
Sbjct: 15 NEEVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKC-IERDEVRNVFRELQ 73
Query: 90 LSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEV 149
+ G++ PF+V + Y+F + + ++DL+ GGDL YHL Q+ F E +K Y E+
Sbjct: 74 ---IMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICEL 130
Query: 150 ILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF-SKKKPHASVGTHGYMAPE 208
L LE++ + HI++RD+KP NILLDEHGHV I+D +A ++ + GT YMAPE
Sbjct: 131 ALALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSMAGTKPYMAPE 190
Query: 209 V----LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXX 264
V + G GY DW+S G Y+LL+G P+ H EI L M +
Sbjct: 191 VFQVYMDGGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEI----LNMFK----- 241
Query: 265 XXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFA 324
+ST + + +LL LL +D R+ +++ + A
Sbjct: 242 -VERVHYSST------------WCKGMVALLRKLLTKDPESRVS----SLHDIQSVPYLA 284
Query: 325 GIDWQQVYHQKYTPPLIPPRGEVNAADAFDI 355
++W V+ + P +P +G +N F++
Sbjct: 285 DMNWDAVFKKALMPGFVPNKGRLNCDPTFEL 315
>BC006106-1|AAH06106.3| 482|Homo sapiens ribosomal protein S6
kinase, 70kDa, polypeptide 2 protein.
Length = 482
Score = 170 bits (413), Expect = 1e-41
Identities = 105/313 (33%), Positives = 164/313 (52%), Gaps = 36/313 (11%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLALN-ERIMLS 91
+ F + R++G+GG+G+V+ RK + GK+YAMK L K +I +T ER +L
Sbjct: 65 HSFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILE 124
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
V PFIV + YAF T KL IL+ ++GG+L HL + G+F E FY AE+ L
Sbjct: 125 SVKH----PFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITL 180
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP--HASVGTHGYMAPEV 209
L H+H + I+YRDLKP NI+L GH++++D GL + + H GT YMAPE+
Sbjct: 181 ALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEI 240
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
L + +G++ + DW+S G ++Y +L G PF K +DK+ L
Sbjct: 241 LVR-SGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKT--MDKIIRGKL----------- 286
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
+P +P + L++ L+R+ ++R+G A +V+ H FF ++W
Sbjct: 287 ------------ALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWD 334
Query: 330 QVYHQKYTPPLIP 342
+ + PP P
Sbjct: 335 DLLAWRVDPPFRP 347
>U33053-1|AAC50209.1| 942|Homo sapiens PRK1 protein.
Length = 942
Score = 169 bits (412), Expect = 2e-41
Identities = 110/334 (32%), Positives = 174/334 (52%), Gaps = 37/334 (11%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK-QGETLALNERIMLS 91
LT+ DF ++GRG FG+V +G+++A+K L K I + + E+L +RI+ +
Sbjct: 610 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 669
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
+ S G PF+V + F TP+ +CF+++ GGDL H+ VF+E FY+A V+L
Sbjct: 670 VTSAGH--PFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVL 726
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEV 209
GL+ +H+ IVYRDLK N+LLD G+V+I+D GL + S GT ++APEV
Sbjct: 727 GLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 786
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
L+ T Y + DW+ G +LY++L G SPF D+ E+
Sbjct: 787 LT-DTSYTRAVDWWGLGVLLYEMLVGESPF---PGDDEEEV------------------- 823
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
++ E P S ++ LL+R+ +RLG R A++VK+ FF + W+
Sbjct: 824 ---FDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWE 880
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT 363
+ ++ PP +P + D+ +FDEE T
Sbjct: 881 ALLARRLPPPFVP-----TLSGRTDVSNFDEEFT 909
>S75546-1|AAB33345.1| 942|Homo sapiens protein kinase PRK1 protein.
Length = 942
Score = 169 bits (412), Expect = 2e-41
Identities = 110/334 (32%), Positives = 174/334 (52%), Gaps = 37/334 (11%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK-QGETLALNERIMLS 91
LT+ DF ++GRG FG+V +G+++A+K L K I + + E+L +RI+ +
Sbjct: 610 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 669
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
+ S G PF+V + F TP+ +CF+++ GGDL H+ VF+E FY+A V+L
Sbjct: 670 VTSAGH--PFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVL 726
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEV 209
GL+ +H+ IVYRDLK N+LLD G+V+I+D GL + S GT ++APEV
Sbjct: 727 GLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 786
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
L+ T Y + DW+ G +LY++L G SPF D+ E+
Sbjct: 787 LT-DTSYTRAVDWWGLGVLLYEMLVGESPF---PGDDEEEV------------------- 823
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
++ E P S ++ LL+R+ +RLG R A++VK+ FF + W+
Sbjct: 824 ---FDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWE 880
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT 363
+ ++ PP +P + D+ +FDEE T
Sbjct: 881 ALLARRLPPPFVP-----TLSGRTDVSNFDEEFT 909
>D26181-1|BAA05169.1| 942|Homo sapiens PKN protein.
Length = 942
Score = 169 bits (412), Expect = 2e-41
Identities = 110/334 (32%), Positives = 174/334 (52%), Gaps = 37/334 (11%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK-QGETLALNERIMLS 91
LT+ DF ++GRG FG+V +G+++A+K L K I + + E+L +RI+ +
Sbjct: 610 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 669
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
+ S G PF+V + F TP+ +CF+++ GGDL H+ VF+E FY+A V+L
Sbjct: 670 VTSAGH--PFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVL 726
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEV 209
GL+ +H+ IVYRDLK N+LLD G+V+I+D GL + S GT ++APEV
Sbjct: 727 GLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 786
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
L+ T Y + DW+ G +LY++L G SPF D+ E+
Sbjct: 787 LT-DTSYTRAVDWWGLGVLLYEMLVGESPF---PGDDEEEV------------------- 823
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
++ E P S ++ LL+R+ +RLG R A++VK+ FF + W+
Sbjct: 824 ---FDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWE 880
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT 363
+ ++ PP +P + D+ +FDEE T
Sbjct: 881 ALLARRLPPPFVP-----TLSGRTDVSNFDEEFT 909
>BC000094-1|AAH00094.3| 482|Homo sapiens ribosomal protein S6
kinase, 70kDa, polypeptide 2 protein.
Length = 482
Score = 169 bits (412), Expect = 2e-41
Identities = 105/311 (33%), Positives = 163/311 (52%), Gaps = 36/311 (11%)
Query: 38 FSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLALN-ERIMLSLV 93
F + R++G+GG+G+V+ RK + GK+YAMK L K +I +T ER +L V
Sbjct: 67 FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV 126
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
PFIV + YAF T KL IL+ ++GG+L HL + G+F E FY AE+ L L
Sbjct: 127 KH----PFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLAL 182
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP--HASVGTHGYMAPEVLS 211
H+H + I+YRDLKP NI+L GH++++D GL + + H GT YMAPE+L
Sbjct: 183 GHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILV 242
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXX 271
+ +G++ + DW+S G ++Y +L G PF K +DK+ L
Sbjct: 243 R-SGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKT--MDKIIRGKL------------- 286
Query: 272 ASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQV 331
+P +P + L++ L+R+ ++R+G A +V+ H FF ++W +
Sbjct: 287 ----------ALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDL 336
Query: 332 YHQKYTPPLIP 342
+ PP P
Sbjct: 337 LAWRVDPPFRP 347
>AF099739-1|AAD20990.1| 482|Homo sapiens S6 kinase-related kinase
protein.
Length = 482
Score = 169 bits (412), Expect = 2e-41
Identities = 105/311 (33%), Positives = 163/311 (52%), Gaps = 36/311 (11%)
Query: 38 FSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLALN-ERIMLSLV 93
F + R++G+GG+G+V+ RK + GK+YAMK L K +I +T ER +L V
Sbjct: 67 FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV 126
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
PFIV + YAF T KL IL+ ++GG+L HL + G+F E FY AE+ L L
Sbjct: 127 KH----PFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLAL 182
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP--HASVGTHGYMAPEVLS 211
H+H + I+YRDLKP NI+L GH++++D GL + + H GT YMAPE+L
Sbjct: 183 GHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILV 242
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXX 271
+ +G++ + DW+S G ++Y +L G PF K +DK+ L
Sbjct: 243 R-SGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKT--MDKIIRGKL------------- 286
Query: 272 ASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQV 331
+P +P + L++ L+R+ ++R+G A +V+ H FF ++W +
Sbjct: 287 ----------ALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDL 336
Query: 332 YHQKYTPPLIP 342
+ PP P
Sbjct: 337 LAWRVDPPFRP 347
>AF076931-1|AAD46063.1| 482|Homo sapiens serine/threonine kinase 14
beta protein.
Length = 482
Score = 169 bits (412), Expect = 2e-41
Identities = 105/311 (33%), Positives = 163/311 (52%), Gaps = 36/311 (11%)
Query: 38 FSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLALN-ERIMLSLV 93
F + R++G+GG+G+V+ RK + GK+YAMK L K +I +T ER +L V
Sbjct: 67 FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV 126
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
PFIV + YAF T KL IL+ ++GG+L HL + G+F E FY AE+ L L
Sbjct: 127 KH----PFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLAL 182
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP--HASVGTHGYMAPEVLS 211
H+H + I+YRDLKP NI+L GH++++D GL + + H GT YMAPE+L
Sbjct: 183 GHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILV 242
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXX 271
+ +G++ + DW+S G ++Y +L G PF K +DK+ L
Sbjct: 243 R-SGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKT--MDKIIRGKL------------- 286
Query: 272 ASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQV 331
+P +P + L++ L+R+ ++R+G A +V+ H FF ++W +
Sbjct: 287 ----------ALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDL 336
Query: 332 YHQKYTPPLIP 342
+ PP P
Sbjct: 337 LAWRVDPPFRP 347
>AB016869-1|BAA34402.1| 495|Homo sapiens p70 ribosomal S6 kinase
beta protein.
Length = 495
Score = 169 bits (412), Expect = 2e-41
Identities = 105/311 (33%), Positives = 163/311 (52%), Gaps = 36/311 (11%)
Query: 38 FSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLALN-ERIMLSLV 93
F + R++G+GG+G+V+ RK + GK+YAMK L K +I +T ER +L V
Sbjct: 80 FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV 139
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
PFIV + YAF T KL IL+ ++GG+L HL + G+F E FY AE+ L L
Sbjct: 140 KH----PFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLAL 195
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP--HASVGTHGYMAPEVLS 211
H+H + I+YRDLKP NI+L GH++++D GL + + H GT YMAPE+L
Sbjct: 196 GHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILV 255
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXX 271
+ +G++ + DW+S G ++Y +L G PF K +DK+ L
Sbjct: 256 R-SGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKT--MDKIIRGKL------------- 299
Query: 272 ASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQV 331
+P +P + L++ L+R+ ++R+G A +V+ H FF ++W +
Sbjct: 300 ----------ALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDL 349
Query: 332 YHQKYTPPLIP 342
+ PP P
Sbjct: 350 LAWRVDPPFRP 360
>L07032-1|AAA60101.1| 706|Homo sapiens protein kinase C-theta
protein.
Length = 706
Score = 169 bits (411), Expect = 2e-41
Identities = 86/213 (40%), Positives = 130/213 (61%), Gaps = 6/213 (2%)
Query: 29 LNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERI 88
L I+L + DF +H+++G+G FG+V+ T + +A+K L K + M + E+
Sbjct: 371 LQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKR 430
Query: 89 MLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAE 148
+LSL + PF+ M F T + L F+++ +NGGDL YH+ F+ + FYAAE
Sbjct: 431 VLSLAW---EHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAE 487
Query: 149 VILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMA 206
+ILGL+ +H + IVYRDLK NILLD+ GH++I+D G+ + K + GT Y+A
Sbjct: 488 IILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIA 547
Query: 207 PEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
PE+L G Y+ S DW+SFG +LY++L G SPF
Sbjct: 548 PEIL-LGQKYNHSVDWWSFGVLLYEMLIGQSPF 579
Score = 40.7 bits (91), Expect = 0.013
Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 9/78 (11%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P K LL L R+ KRLG +G ++++H F I+W+++ ++ PP P
Sbjct: 599 PRWLEKEAKDLLVKLFVREPEKRLGVRG----DIRQHPLFREINWEELERKEIDPPFRP- 653
Query: 344 RGEVNAADAFDIGSFDEE 361
FD +FD+E
Sbjct: 654 ----KVKSPFDCSNFDKE 667
>L01087-1|AAA75571.1| 706|Homo sapiens protein kinase C-theta
protein.
Length = 706
Score = 169 bits (411), Expect = 2e-41
Identities = 86/213 (40%), Positives = 130/213 (61%), Gaps = 6/213 (2%)
Query: 29 LNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERI 88
L I+L + DF +H+++G+G FG+V+ T + +A+K L K + M + E+
Sbjct: 371 LQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKR 430
Query: 89 MLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAE 148
+LSL + PF+ M F T + L F+++ +NGGDL YH+ F+ + FYAAE
Sbjct: 431 VLSLAW---EHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAE 487
Query: 149 VILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMA 206
+ILGL+ +H + IVYRDLK NILLD+ GH++I+D G+ + K + GT Y+A
Sbjct: 488 IILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIA 547
Query: 207 PEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
PE+L G Y+ S DW+SFG +LY++L G SPF
Sbjct: 548 PEIL-LGQKYNHSVDWWSFGVLLYEMLIGQSPF 579
Score = 40.7 bits (91), Expect = 0.013
Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 9/78 (11%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P K LL L R+ KRLG +G ++++H F I+W+++ ++ PP P
Sbjct: 599 PRWLEKEAKDLLVKLFVREPEKRLGVRG----DIRQHPLFREINWEELERKEIDPPFRP- 653
Query: 344 RGEVNAADAFDIGSFDEE 361
FD +FD+E
Sbjct: 654 ----KVKSPFDCSNFDKE 667
>BT020098-1|AAV38901.1| 367|Homo sapiens serum/glucocorticoid
regulated kinase 2 protein.
Length = 367
Score = 169 bits (411), Expect = 2e-41
Identities = 87/215 (40%), Positives = 129/215 (60%), Gaps = 6/215 (2%)
Query: 37 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 96
DF ++IG+G +G+V ++ G YA+K L KK I K+ ++ + ER S++
Sbjct: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAER---SVLLKN 90
Query: 97 VDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHM 156
V PF+V + Y+F TP+KL F+LD +NGG+L +HL + F E +FYAAEV ++++
Sbjct: 91 VRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIDYL 150
Query: 157 HKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKGT 214
H +I+YRDLKP NILLD GHV ++D GL + + + S GT Y+APEVL K
Sbjct: 151 HSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRK-E 209
Query: 215 GYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHE 249
YD + DW+ G +LY++L G PF +E
Sbjct: 210 PYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYE 244
Score = 55.2 bits (127), Expect = 6e-07
Identities = 30/82 (36%), Positives = 44/82 (53%), Gaps = 6/82 (7%)
Query: 283 VPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIP 342
+P + + LL+ LL +D +RLG K E+K HVFF+ I+W +YH++ TPP P
Sbjct: 253 IPGGRTVAACDLLQSLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNP 311
Query: 343 PRGEVNAADAFDIGSFDEEDTK 364
N D+ FD E T+
Sbjct: 312 -----NVTGPADLKHFDPEFTQ 328
>BC113359-1|AAI13360.1| 706|Homo sapiens protein kinase C, theta
protein.
Length = 706
Score = 169 bits (411), Expect = 2e-41
Identities = 86/213 (40%), Positives = 130/213 (61%), Gaps = 6/213 (2%)
Query: 29 LNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERI 88
L I+L + DF +H+++G+G FG+V+ T + +A+K L K + M + E+
Sbjct: 371 LQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKR 430
Query: 89 MLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAE 148
+LSL + PF+ M F T + L F+++ +NGGDL YH+ F+ + FYAAE
Sbjct: 431 VLSLAW---EHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAE 487
Query: 149 VILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMA 206
+ILGL+ +H + IVYRDLK NILLD+ GH++I+D G+ + K + GT Y+A
Sbjct: 488 IILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIA 547
Query: 207 PEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
PE+L G Y+ S DW+SFG +LY++L G SPF
Sbjct: 548 PEIL-LGQKYNHSVDWWSFGVLLYEMLIGQSPF 579
Score = 40.7 bits (91), Expect = 0.013
Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 9/78 (11%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P K LL L R+ KRLG +G ++++H F I+W+++ ++ PP P
Sbjct: 599 PRWLEKEAKDLLVKLFVREPEKRLGVRG----DIRQHPLFREINWEELERKEIDPPFRP- 653
Query: 344 RGEVNAADAFDIGSFDEE 361
FD +FD+E
Sbjct: 654 ----KVKSPFDCSNFDKE 667
>BC101465-1|AAI01466.1| 706|Homo sapiens protein kinase C, theta
protein.
Length = 706
Score = 169 bits (411), Expect = 2e-41
Identities = 86/213 (40%), Positives = 130/213 (61%), Gaps = 6/213 (2%)
Query: 29 LNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERI 88
L I+L + DF +H+++G+G FG+V+ T + +A+K L K + M + E+
Sbjct: 371 LQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKR 430
Query: 89 MLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAE 148
+LSL + PF+ M F T + L F+++ +NGGDL YH+ F+ + FYAAE
Sbjct: 431 VLSLAW---EHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAE 487
Query: 149 VILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMA 206
+ILGL+ +H + IVYRDLK NILLD+ GH++I+D G+ + K + GT Y+A
Sbjct: 488 IILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIA 547
Query: 207 PEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
PE+L G Y+ S DW+SFG +LY++L G SPF
Sbjct: 548 PEIL-LGQKYNHSVDWWSFGVLLYEMLIGQSPF 579
Score = 40.7 bits (91), Expect = 0.013
Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 9/78 (11%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P K LL L R+ KRLG +G ++++H F I+W+++ ++ PP P
Sbjct: 599 PRWLEKEAKDLLVKLFVREPEKRLGVRG----DIRQHPLFREINWEELERKEIDPPFRP- 653
Query: 344 RGEVNAADAFDIGSFDEE 361
FD +FD+E
Sbjct: 654 ----KVKSPFDCSNFDKE 667
>AL158043-2|CAC12904.2| 706|Homo sapiens protein kinase C, theta
protein.
Length = 706
Score = 169 bits (411), Expect = 2e-41
Identities = 86/213 (40%), Positives = 130/213 (61%), Gaps = 6/213 (2%)
Query: 29 LNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERI 88
L I+L + DF +H+++G+G FG+V+ T + +A+K L K + M + E+
Sbjct: 371 LQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKR 430
Query: 89 MLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAE 148
+LSL + PF+ M F T + L F+++ +NGGDL YH+ F+ + FYAAE
Sbjct: 431 VLSLAW---EHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAE 487
Query: 149 VILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMA 206
+ILGL+ +H + IVYRDLK NILLD+ GH++I+D G+ + K + GT Y+A
Sbjct: 488 IILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIA 547
Query: 207 PEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
PE+L G Y+ S DW+SFG +LY++L G SPF
Sbjct: 548 PEIL-LGQKYNHSVDWWSFGVLLYEMLIGQSPF 579
Score = 40.7 bits (91), Expect = 0.013
Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 9/78 (11%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P K LL L R+ KRLG +G ++++H F I+W+++ ++ PP P
Sbjct: 599 PRWLEKEAKDLLVKLFVREPEKRLGVRG----DIRQHPLFREINWEELERKEIDPPFRP- 653
Query: 344 RGEVNAADAFDIGSFDEE 361
FD +FD+E
Sbjct: 654 ----KVKSPFDCSNFDKE 667
>AL158043-1|CAI16127.1| 478|Homo sapiens protein kinase C, theta
protein.
Length = 478
Score = 169 bits (411), Expect = 2e-41
Identities = 86/213 (40%), Positives = 130/213 (61%), Gaps = 6/213 (2%)
Query: 29 LNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERI 88
L I+L + DF +H+++G+G FG+V+ T + +A+K L K + M + E+
Sbjct: 143 LQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKR 202
Query: 89 MLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAE 148
+LSL + PF+ M F T + L F+++ +NGGDL YH+ F+ + FYAAE
Sbjct: 203 VLSLAW---EHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAE 259
Query: 149 VILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMA 206
+ILGL+ +H + IVYRDLK NILLD+ GH++I+D G+ + K + GT Y+A
Sbjct: 260 IILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIA 319
Query: 207 PEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
PE+L G Y+ S DW+SFG +LY++L G SPF
Sbjct: 320 PEIL-LGQKYNHSVDWWSFGVLLYEMLIGQSPF 351
Score = 40.7 bits (91), Expect = 0.013
Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 9/78 (11%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P K LL L R+ KRLG +G ++++H F I+W+++ ++ PP P
Sbjct: 371 PRWLEKEAKDLLVKLFVREPEKRLGVRG----DIRQHPLFREINWEELERKEIDPPFRP- 425
Query: 344 RGEVNAADAFDIGSFDEE 361
FD +FD+E
Sbjct: 426 ----KVKSPFDCSNFDKE 439
>AL137145-2|CAC10200.2| 706|Homo sapiens protein kinase C, theta
protein.
Length = 706
Score = 169 bits (411), Expect = 2e-41
Identities = 86/213 (40%), Positives = 130/213 (61%), Gaps = 6/213 (2%)
Query: 29 LNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERI 88
L I+L + DF +H+++G+G FG+V+ T + +A+K L K + M + E+
Sbjct: 371 LQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKR 430
Query: 89 MLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAE 148
+LSL + PF+ M F T + L F+++ +NGGDL YH+ F+ + FYAAE
Sbjct: 431 VLSLAW---EHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAE 487
Query: 149 VILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMA 206
+ILGL+ +H + IVYRDLK NILLD+ GH++I+D G+ + K + GT Y+A
Sbjct: 488 IILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIA 547
Query: 207 PEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
PE+L G Y+ S DW+SFG +LY++L G SPF
Sbjct: 548 PEIL-LGQKYNHSVDWWSFGVLLYEMLIGQSPF 579
Score = 40.7 bits (91), Expect = 0.013
Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 9/78 (11%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P K LL L R+ KRLG +G ++++H F I+W+++ ++ PP P
Sbjct: 599 PRWLEKEAKDLLVKLFVREPEKRLGVRG----DIRQHPLFREINWEELERKEIDPPFRP- 653
Query: 344 RGEVNAADAFDIGSFDEE 361
FD +FD+E
Sbjct: 654 ----KVKSPFDCSNFDKE 667
>AL137145-1|CAI15756.1| 478|Homo sapiens protein kinase C, theta
protein.
Length = 478
Score = 169 bits (411), Expect = 2e-41
Identities = 86/213 (40%), Positives = 130/213 (61%), Gaps = 6/213 (2%)
Query: 29 LNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERI 88
L I+L + DF +H+++G+G FG+V+ T + +A+K L K + M + E+
Sbjct: 143 LQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKR 202
Query: 89 MLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAE 148
+LSL + PF+ M F T + L F+++ +NGGDL YH+ F+ + FYAAE
Sbjct: 203 VLSLAW---EHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAE 259
Query: 149 VILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMA 206
+ILGL+ +H + IVYRDLK NILLD+ GH++I+D G+ + K + GT Y+A
Sbjct: 260 IILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIA 319
Query: 207 PEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
PE+L G Y+ S DW+SFG +LY++L G SPF
Sbjct: 320 PEIL-LGQKYNHSVDWWSFGVLLYEMLIGQSPF 351
Score = 40.7 bits (91), Expect = 0.013
Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 9/78 (11%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P K LL L R+ KRLG +G ++++H F I+W+++ ++ PP P
Sbjct: 371 PRWLEKEAKDLLVKLFVREPEKRLGVRG----DIRQHPLFREINWEELERKEIDPPFRP- 425
Query: 344 RGEVNAADAFDIGSFDEE 361
FD +FD+E
Sbjct: 426 ----KVKSPFDCSNFDKE 439
>U33052-1|AAC50208.1| 984|Homo sapiens PRK2 protein.
Length = 984
Score = 169 bits (410), Expect = 3e-41
Identities = 112/335 (33%), Positives = 172/335 (51%), Gaps = 37/335 (11%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
Q + DF ++GRG FG+V +T +M+A+K L K I + + E+ +
Sbjct: 651 QFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFE 710
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
V++ V PF+V + F T + +CF+++ GGDL H+ VF+E FYAA V+L
Sbjct: 711 TVNS-VRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVL 768
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEV 209
GL+++H+ IVYRDLK N+LLD G V+I+D GL + S GT ++APEV
Sbjct: 769 GLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 828
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
L++ T Y + DW+ G ++Y++L G SPF D+ E+
Sbjct: 829 LTE-TSYTRAVDWWGLGVLIYEMLVGESPF---PGDDEEEV------------------- 865
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
++ E P S S++ LL+R+ +RLG + A++VK+H FF IDW
Sbjct: 866 ---FDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWS 922
Query: 330 QVYHQKYTPPLIPP-RGEVNAADAFDIGSFDEEDT 363
+ +K PP IP RG D+ +FD+E T
Sbjct: 923 ALMDKKVKPPFIPTIRGRE------DVSNFDDEFT 951
>S75548-1|AAB33346.1| 984|Homo sapiens protein kinase PRK2 protein.
Length = 984
Score = 169 bits (410), Expect = 3e-41
Identities = 112/335 (33%), Positives = 172/335 (51%), Gaps = 37/335 (11%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
Q + DF ++GRG FG+V +T +M+A+K L K I + + E+ +
Sbjct: 651 QFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFE 710
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
V++ V PF+V + F T + +CF+++ GGDL H+ VF+E FYAA V+L
Sbjct: 711 TVNS-VRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVL 768
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEV 209
GL+++H+ IVYRDLK N+LLD G V+I+D GL + S GT ++APEV
Sbjct: 769 GLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 828
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
L++ T Y + DW+ G ++Y++L G SPF D+ E+
Sbjct: 829 LTE-TSYTRAVDWWGLGVLIYEMLVGESPF---PGDDEEEV------------------- 865
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
++ E P S S++ LL+R+ +RLG + A++VK+H FF IDW
Sbjct: 866 ---FDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWS 922
Query: 330 QVYHQKYTPPLIPP-RGEVNAADAFDIGSFDEEDT 363
+ +K PP IP RG D+ +FD+E T
Sbjct: 923 ALMDKKVKPPFIPTIRGRE------DVSNFDDEFT 951
>AL136381-3|CAI23271.1| 984|Homo sapiens protein kinase N2 protein.
Length = 984
Score = 169 bits (410), Expect = 3e-41
Identities = 112/335 (33%), Positives = 172/335 (51%), Gaps = 37/335 (11%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
Q + DF ++GRG FG+V +T +M+A+K L K I + + E+ +
Sbjct: 651 QFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFE 710
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
V++ V PF+V + F T + +CF+++ GGDL H+ VF+E FYAA V+L
Sbjct: 711 TVNS-VRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVL 768
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEV 209
GL+++H+ IVYRDLK N+LLD G V+I+D GL + S GT ++APEV
Sbjct: 769 GLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 828
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
L++ T Y + DW+ G ++Y++L G SPF D+ E+
Sbjct: 829 LTE-TSYTRAVDWWGLGVLIYEMLVGESPF---PGDDEEEV------------------- 865
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
++ E P S S++ LL+R+ +RLG + A++VK+H FF IDW
Sbjct: 866 ---FDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWS 922
Query: 330 QVYHQKYTPPLIPP-RGEVNAADAFDIGSFDEEDT 363
+ +K PP IP RG D+ +FD+E T
Sbjct: 923 ALMDKKVKPPFIPTIRGRE------DVSNFDDEFT 951
>M55284-1|AAA60100.1| 682|Homo sapiens protein kinase C-L protein.
Length = 682
Score = 168 bits (409), Expect = 4e-41
Identities = 106/333 (31%), Positives = 167/333 (50%), Gaps = 32/333 (9%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
+L +++F R++G+G FG+V R +TG +YA+K L K I + + E+ +LS
Sbjct: 348 RLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILLDDDVECTMTEKRILS 407
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
L PF+ + F TPD+L F+++ +NGGDL +H+ + F+EA +FYAAE+I
Sbjct: 408 LARNH---PFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIIS 464
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEV 209
L +H + I+YRDLK N+LLD GH +++D G+ + + GT Y+APE+
Sbjct: 465 ALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEI 524
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
L + Y + DW++ G +LY++L GH+PF D E +L +
Sbjct: 525 LQEML-YGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFE------AILNDEVVY----- 572
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADE-VKEHVFFAGIDW 328
T L E G+ +SF + ++ RLG +G + + H FF IDW
Sbjct: 573 ---PTWLHEDATGILKSF-----------MTKNPTMRLGSLTQGGEHAILRHPFFKEIDW 618
Query: 329 QQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEE 361
Q+ H++ PP P FD EE
Sbjct: 619 AQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEE 651
>BC125199-1|AAI25200.1| 936|Homo sapiens PKN2 protein protein.
Length = 936
Score = 168 bits (408), Expect = 5e-41
Identities = 112/335 (33%), Positives = 172/335 (51%), Gaps = 37/335 (11%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
Q + DF ++GRG FG+V +T +M+A+K L K I + + E+ +
Sbjct: 603 QFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFE 662
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
V++ V PF+V + F T + +CF+++ GGDL H+ VF+E FYAA V+L
Sbjct: 663 TVNS-VRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVL 720
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEV 209
GL+++H+ IVYRDLK N+LLD G V+I+D GL + S GT ++APEV
Sbjct: 721 GLQYLHEHKIVYRDLKLDNLLLDTEGLVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 780
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
L++ T Y + DW+ G ++Y++L G SPF D+ E+
Sbjct: 781 LTE-TSYTRAVDWWGLGVLIYEMLVGESPF---PGDDEEEV------------------- 817
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
++ E P S S++ LL+R+ +RLG + A++VK+H FF IDW
Sbjct: 818 ---FDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWS 874
Query: 330 QVYHQKYTPPLIPP-RGEVNAADAFDIGSFDEEDT 363
+ +K PP IP RG D+ +FD+E T
Sbjct: 875 ALMDKKVKPPFIPTIRGRE------DVSNFDDEFT 903
>Z98752-7|CAC18509.1| 367|Homo sapiens serum/glucocorticoid
regulated kinase 2 protein.
Length = 367
Score = 167 bits (407), Expect = 7e-41
Identities = 87/215 (40%), Positives = 128/215 (59%), Gaps = 6/215 (2%)
Query: 37 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 96
DF ++IG+G +G+V ++ G YA+K L KK I K+ ++ + ER S++
Sbjct: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAER---SVLLKN 90
Query: 97 VDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHM 156
V PF+V + Y+F TP+KL F+LD +NGG+L +HL + F E +FYAAEV + ++
Sbjct: 91 VRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYL 150
Query: 157 HKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKGT 214
H +I+YRDLKP NILLD GHV ++D GL + + + S GT Y+APEVL K
Sbjct: 151 HSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRK-E 209
Query: 215 GYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHE 249
YD + DW+ G +LY++L G PF +E
Sbjct: 210 PYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYE 244
Score = 55.2 bits (127), Expect = 6e-07
Identities = 30/82 (36%), Positives = 44/82 (53%), Gaps = 6/82 (7%)
Query: 283 VPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIP 342
+P + + LL+ LL +D +RLG K E+K HVFF+ I+W +YH++ TPP P
Sbjct: 253 IPGGRTVAACDLLQSLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNP 311
Query: 343 PRGEVNAADAFDIGSFDEEDTK 364
N D+ FD E T+
Sbjct: 312 -----NVTGPADLKHFDPEFTQ 328
>Z98752-5|CAI42312.1| 427|Homo sapiens serum/glucocorticoid
regulated kinase 2 protein.
Length = 427
Score = 167 bits (407), Expect = 7e-41
Identities = 87/215 (40%), Positives = 128/215 (59%), Gaps = 6/215 (2%)
Query: 37 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 96
DF ++IG+G +G+V ++ G YA+K L KK I K+ ++ + ER S++
Sbjct: 94 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAER---SVLLKN 150
Query: 97 VDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHM 156
V PF+V + Y+F TP+KL F+LD +NGG+L +HL + F E +FYAAEV + ++
Sbjct: 151 VRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYL 210
Query: 157 HKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKGT 214
H +I+YRDLKP NILLD GHV ++D GL + + + S GT Y+APEVL K
Sbjct: 211 HSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRK-E 269
Query: 215 GYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHE 249
YD + DW+ G +LY++L G PF +E
Sbjct: 270 PYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYE 304
Score = 55.2 bits (127), Expect = 6e-07
Identities = 30/82 (36%), Positives = 44/82 (53%), Gaps = 6/82 (7%)
Query: 283 VPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIP 342
+P + + LL+ LL +D +RLG K E+K HVFF+ I+W +YH++ TPP P
Sbjct: 313 IPGGRTVAACDLLQSLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNP 371
Query: 343 PRGEVNAADAFDIGSFDEEDTK 364
N D+ FD E T+
Sbjct: 372 -----NVTGPADLKHFDPEFTQ 388
>Z15114-1|CAA78820.1| 536|Homo sapiens protein kinase C gamma
protein.
Length = 536
Score = 167 bits (407), Expect = 7e-41
Identities = 101/315 (32%), Positives = 160/315 (50%), Gaps = 30/315 (9%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
+L ++DFS ++G+G FG+V + + ++YA+K L K I L E+ +L+
Sbjct: 184 RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA 243
Query: 92 LVSTGVDCP--FIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEV 149
L G F+ + F TPD+L F+++ + GGDL YH+ Q G F E FYAAE+
Sbjct: 244 LGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEI 303
Query: 150 ILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAP 207
+GL +H + I+YRDLK N++LD GH++I+D G+ + F GT Y+AP
Sbjct: 304 AIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAP 363
Query: 208 EVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXX 267
E+++ Y S DW+SFG +LY++L G PF +D+ E+ + +
Sbjct: 364 EIIAY-QPYGKSVDWWSFGVLLYEMLAGQPPF---DGEDEEELFQAIM------------ 407
Query: 268 XXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGID 327
E P+S S ++ +G L + KRLG G ++ H FF ID
Sbjct: 408 ----------EQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWID 457
Query: 328 WQQVYHQKYTPPLIP 342
W+++ + PP P
Sbjct: 458 WERLERLEIPPPFRP 472
>BC065511-1|AAH65511.1| 367|Homo sapiens SGK2 protein protein.
Length = 367
Score = 167 bits (407), Expect = 7e-41
Identities = 87/215 (40%), Positives = 128/215 (59%), Gaps = 6/215 (2%)
Query: 37 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 96
DF ++IG+G +G+V ++ G YA+K L KK I K+ ++ + ER S++
Sbjct: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAER---SVLLKN 90
Query: 97 VDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHM 156
V PF+V + Y+F TP+KL F+LD +NGG+L +HL + F E +FYAAEV + ++
Sbjct: 91 VRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYL 150
Query: 157 HKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKGT 214
H +I+YRDLKP NILLD GHV ++D GL + + + S GT Y+APEVL K
Sbjct: 151 HSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRK-E 209
Query: 215 GYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHE 249
YD + DW+ G +LY++L G PF +E
Sbjct: 210 PYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYE 244
Score = 55.2 bits (127), Expect = 6e-07
Identities = 30/82 (36%), Positives = 44/82 (53%), Gaps = 6/82 (7%)
Query: 283 VPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIP 342
+P + + LL+ LL +D +RLG K E+K HVFF+ I+W +YH++ TPP P
Sbjct: 253 IPGGRTVAACDLLQSLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNP 311
Query: 343 PRGEVNAADAFDIGSFDEEDTK 364
N D+ FD E T+
Sbjct: 312 -----NVTGPADLKHFDPEFTQ 328
>BC047876-1|AAH47876.1| 697|Homo sapiens protein kinase C, gamma
protein.
Length = 697
Score = 167 bits (407), Expect = 7e-41
Identities = 101/315 (32%), Positives = 160/315 (50%), Gaps = 30/315 (9%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
+L ++DFS ++G+G FG+V + + ++YA+K L K I L E+ +L+
Sbjct: 345 RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA 404
Query: 92 LVSTGVDCP--FIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEV 149
L G F+ + F TPD+L F+++ + GGDL YH+ Q G F E FYAAE+
Sbjct: 405 LGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEI 464
Query: 150 ILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAP 207
+GL +H + I+YRDLK N++LD GH++I+D G+ + F GT Y+AP
Sbjct: 465 AIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAP 524
Query: 208 EVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXX 267
E+++ Y S DW+SFG +LY++L G PF +D+ E+ + +
Sbjct: 525 EIIAY-QPYGKSVDWWSFGVLLYEMLAGQPPF---DGEDEEELFQAIM------------ 568
Query: 268 XXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGID 327
E P+S S ++ +G L + KRLG G ++ H FF ID
Sbjct: 569 ----------EQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWID 618
Query: 328 WQQVYHQKYTPPLIP 342
W+++ + PP P
Sbjct: 619 WERLERLEIPPPFRP 633
>BC037268-1|AAH37268.1| 683|Homo sapiens protein kinase C, eta
protein.
Length = 683
Score = 167 bits (407), Expect = 7e-41
Identities = 106/333 (31%), Positives = 166/333 (49%), Gaps = 32/333 (9%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
+L +++F R++G+G FG+V R +TG +YA+K L K I + E+ +LS
Sbjct: 349 RLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILS 408
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
L PF+ + F TPD+L F+++ +NGGDL +H+ + F+EA +FYAAE+I
Sbjct: 409 LARNH---PFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIIS 465
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEV 209
L +H + I+YRDLK N+LLD GH +++D G+ + + GT Y+APE+
Sbjct: 466 ALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEI 525
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
L + Y + DW++ G +LY++L GH+PF D E +L +
Sbjct: 526 LQEML-YGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFE------AILNDEVVY----- 573
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADE-VKEHVFFAGIDW 328
T L E G+ +SF + ++ RLG +G + + H FF IDW
Sbjct: 574 ---PTWLHEDATGILKSF-----------MTKNPTMRLGSLTQGGEHAILRHPFFKEIDW 619
Query: 329 QQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEE 361
Q+ H++ PP P FD EE
Sbjct: 620 AQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEE 652
>BC014037-1|AAH14037.3| 367|Homo sapiens serum/glucocorticoid
regulated kinase 2 protein.
Length = 367
Score = 167 bits (407), Expect = 7e-41
Identities = 87/215 (40%), Positives = 128/215 (59%), Gaps = 6/215 (2%)
Query: 37 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 96
DF ++IG+G +G+V ++ G YA+K L KK I K+ ++ + ER S++
Sbjct: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAER---SVLLKN 90
Query: 97 VDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHM 156
V PF+V + Y+F TP+KL F+LD +NGG+L +HL + F E +FYAAEV + ++
Sbjct: 91 VRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYL 150
Query: 157 HKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKGT 214
H +I+YRDLKP NILLD GHV ++D GL + + + S GT Y+APEVL K
Sbjct: 151 HSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRK-E 209
Query: 215 GYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHE 249
YD + DW+ G +LY++L G PF +E
Sbjct: 210 PYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYE 244
Score = 55.2 bits (127), Expect = 6e-07
Identities = 30/82 (36%), Positives = 44/82 (53%), Gaps = 6/82 (7%)
Query: 283 VPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIP 342
+P + + LL+ LL +D +RLG K E+K HVFF+ I+W +YH++ TPP P
Sbjct: 253 IPGGRTVAACDLLQSLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNP 311
Query: 343 PRGEVNAADAFDIGSFDEEDTK 364
N D+ FD E T+
Sbjct: 312 -----NVTGPADLKHFDPEFTQ 328
>AF345987-1|AAK13533.1| 697|Homo sapiens protein kinase C gamma
protein.
Length = 697
Score = 167 bits (407), Expect = 7e-41
Identities = 101/315 (32%), Positives = 160/315 (50%), Gaps = 30/315 (9%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
+L ++DFS ++G+G FG+V + + ++YA+K L K I L E+ +L+
Sbjct: 345 RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA 404
Query: 92 LVSTGVDCP--FIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEV 149
L G F+ + F TPD+L F+++ + GGDL YH+ Q G F E FYAAE+
Sbjct: 405 LGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEI 464
Query: 150 ILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAP 207
+GL +H + I+YRDLK N++LD GH++I+D G+ + F GT Y+AP
Sbjct: 465 AIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAP 524
Query: 208 EVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXX 267
E+++ Y S DW+SFG +LY++L G PF +D+ E+ + +
Sbjct: 525 EIIAY-QPYGKSVDWWSFGVLLYEMLAGQPPF---DGEDEEELFQAIM------------ 568
Query: 268 XXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGID 327
E P+S S ++ +G L + KRLG G ++ H FF ID
Sbjct: 569 ----------EQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWID 618
Query: 328 WQQVYHQKYTPPLIP 342
W+++ + PP P
Sbjct: 619 WERLERLEIPPPFRP 633
>AF186470-1|AAG17012.1| 427|Homo sapiens protein kinase protein.
Length = 427
Score = 167 bits (407), Expect = 7e-41
Identities = 87/215 (40%), Positives = 128/215 (59%), Gaps = 6/215 (2%)
Query: 37 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 96
DF ++IG+G +G+V ++ G YA+K L KK I K+ ++ + ER S++
Sbjct: 94 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAER---SVLLKN 150
Query: 97 VDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHM 156
V PF+V + Y+F TP+KL F+LD +NGG+L +HL + F E +FYAAEV + ++
Sbjct: 151 VRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYL 210
Query: 157 HKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKGT 214
H +I+YRDLKP NILLD GHV ++D GL + + + S GT Y+APEVL K
Sbjct: 211 HSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRK-E 269
Query: 215 GYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHE 249
YD + DW+ G +LY++L G PF +E
Sbjct: 270 PYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYE 304
Score = 55.2 bits (127), Expect = 6e-07
Identities = 30/82 (36%), Positives = 44/82 (53%), Gaps = 6/82 (7%)
Query: 283 VPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIP 342
+P + + LL+ LL +D +RLG K E+K HVFF+ I+W +YH++ TPP P
Sbjct: 313 IPGGRTVAACDLLQSLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNP 371
Query: 343 PRGEVNAADAFDIGSFDEEDTK 364
N D+ FD E T+
Sbjct: 372 -----NVTGPADLKHFDPEFTQ 388
>AF169034-1|AAF12757.2| 367|Homo sapiens protein kinase protein.
Length = 367
Score = 167 bits (407), Expect = 7e-41
Identities = 87/215 (40%), Positives = 128/215 (59%), Gaps = 6/215 (2%)
Query: 37 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 96
DF ++IG+G +G+V ++ G YA+K L KK I K+ ++ + ER S++
Sbjct: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAER---SVLLKN 90
Query: 97 VDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHM 156
V PF+V + Y+F TP+KL F+LD +NGG+L +HL + F E +FYAAEV + ++
Sbjct: 91 VRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYL 150
Query: 157 HKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKGT 214
H +I+YRDLKP NILLD GHV ++D GL + + + S GT Y+APEVL K
Sbjct: 151 HSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRK-E 209
Query: 215 GYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHE 249
YD + DW+ G +LY++L G PF +E
Sbjct: 210 PYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYE 244
Score = 55.2 bits (127), Expect = 6e-07
Identities = 30/82 (36%), Positives = 44/82 (53%), Gaps = 6/82 (7%)
Query: 283 VPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIP 342
+P + + LL+ LL +D +RLG K E+K HVFF+ I+W +YH++ TPP P
Sbjct: 253 IPGGRTVAACDLLQSLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNP 311
Query: 343 PRGEVNAADAFDIGSFDEEDTK 364
N D+ FD E T+
Sbjct: 312 -----NVTGPADLKHFDPEFTQ 328
>X80229-1|CAA56515.1| 479|Homo sapiens serine/threonine protein
kinase protein.
Length = 479
Score = 167 bits (406), Expect = 9e-41
Identities = 110/334 (32%), Positives = 173/334 (51%), Gaps = 37/334 (11%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK-QGETLALNERIMLS 91
LT+ DF ++GRG FG+V +G+++A+K L K I + + E+L +RI+ +
Sbjct: 147 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 206
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
+ S G PF+V + F TP+ +CF+++ GGDL H+ VF+E FY+A V+L
Sbjct: 207 VTSAGH--PFLVNLFGCFQTPEHVCFVMEYSAGGDLILHIHSD-VFSEPRAIFYSACVVL 263
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEV 209
GL+ +H+ IVYRDLK N+LLD G+V+I+D GL + S GT ++APEV
Sbjct: 264 GLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 323
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
L+ T Y + DW+ G +LY++L G SP D+ E+
Sbjct: 324 LT-DTSYTRAVDWWGLGVLLYEMLVGESPL---PGDDEEEV------------------- 360
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
++ E P S ++ LL+R+ +RLG R A++VK+ FF + W+
Sbjct: 361 ---FDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWE 417
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT 363
+ ++ PP +P + DI +FDEE T
Sbjct: 418 ALLARRLPPPFVP-----TLSGRTDISNFDEEFT 446
>Z98752-8|CAI42315.1| 366|Homo sapiens serum/glucocorticoid
regulated kinase 2 protein.
Length = 366
Score = 166 bits (404), Expect = 2e-40
Identities = 88/215 (40%), Positives = 129/215 (60%), Gaps = 7/215 (3%)
Query: 37 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 96
DF ++IG+G +G+V ++ G YA+K L KK I +K+ E+ + ER S++
Sbjct: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSI-LKKKESHIMAER---SVLLKN 89
Query: 97 VDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHM 156
V PF+V + Y+F TP+KL F+LD +NGG+L +HL + F E +FYAAEV + ++
Sbjct: 90 VRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYL 149
Query: 157 HKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKGT 214
H +I+YRDLKP NILLD GHV ++D GL + + + S GT Y+APEVL K
Sbjct: 150 HSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRK-E 208
Query: 215 GYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHE 249
YD + DW+ G +LY++L G PF +E
Sbjct: 209 PYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYE 243
Score = 55.2 bits (127), Expect = 6e-07
Identities = 30/82 (36%), Positives = 44/82 (53%), Gaps = 6/82 (7%)
Query: 283 VPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIP 342
+P + + LL+ LL +D +RLG K E+K HVFF+ I+W +YH++ TPP P
Sbjct: 252 IPGGRTVAACDLLQSLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNP 310
Query: 343 PRGEVNAADAFDIGSFDEEDTK 364
N D+ FD E T+
Sbjct: 311 -----NVTGPADLKHFDPEFTQ 327
>AY987010-1|AAX88805.1| 393|Homo sapiens serum/glucocorticoid
regulated kinase 2 protein.
Length = 393
Score = 166 bits (403), Expect = 2e-40
Identities = 86/215 (40%), Positives = 128/215 (59%), Gaps = 6/215 (2%)
Query: 37 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 96
DF ++IG+G +G+V ++ G YA+K L KK I K+ ++ + ER S++
Sbjct: 60 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAER---SVLLKN 116
Query: 97 VDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHM 156
V PF+V + Y+F TP++L F+LD +NGG+L +HL + F E +FYAAEV + ++
Sbjct: 117 VRHPFLVGLRYSFQTPEELYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYL 176
Query: 157 HKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKGT 214
H +I+YRDLKP NILLD GHV ++D GL + + + S GT Y+APEVL K
Sbjct: 177 HSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRK-E 235
Query: 215 GYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHE 249
YD + DW+ G +LY++L G PF +E
Sbjct: 236 PYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYE 270
Score = 52.4 bits (120), Expect = 4e-06
Identities = 29/82 (35%), Positives = 43/82 (52%), Gaps = 6/82 (7%)
Query: 283 VPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIP 342
+P + + LL+ LL +D +R G K E+K HVFF+ I+W +YH++ TPP P
Sbjct: 279 IPGGRTVAACDLLQSLLHKDQRQRPGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNP 337
Query: 343 PRGEVNAADAFDIGSFDEEDTK 364
N D+ FD E T+
Sbjct: 338 -----NVTGPADLKHFDPEFTQ 354
>Z15108-1|CAA78813.1| 584|Homo sapiens protein kinase C zeta
protein.
Length = 584
Score = 165 bits (400), Expect = 5e-40
Identities = 102/351 (29%), Positives = 176/351 (50%), Gaps = 31/351 (8%)
Query: 27 LELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE 86
++++ L + DF + R+IGRG + +V R ++YAMK + K+ + + E
Sbjct: 233 IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE 292
Query: 87 RIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYA 146
+ + S+ PF+V + F T +L +++ +NGGDL +H+ + E +FYA
Sbjct: 293 KHVFEQASSN---PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYA 349
Query: 147 AEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGY 204
AE+ + L +H+R I+YRDLK N+LLD GH++++D G+ + S GT Y
Sbjct: 350 AEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNY 409
Query: 205 MAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXX 264
+APE+L +G Y S DW++ G ++++++ G SPF D +T N
Sbjct: 410 IAPEIL-RGEEYGFSVDWWALGVLMFEMMAGRSPF-----------DIITDNPDMNTEDY 457
Query: 265 XXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGR-GADEVKEHVFF 323
+ E +P S +L+G L +D +RLGC+ + G ++K H FF
Sbjct: 458 LF-------QVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFF 510
Query: 324 AGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT-KGIKLTETDQ 373
IDW + ++ PP P D + + +FD + T + ++LT D+
Sbjct: 511 RSIDWDLLEKKQALPPFQP-----QITDDYGLDNFDTQFTSEPVQLTPDDE 556
>BT007082-1|AAP35745.1| 592|Homo sapiens protein kinase C, zeta
protein.
Length = 592
Score = 165 bits (400), Expect = 5e-40
Identities = 102/351 (29%), Positives = 176/351 (50%), Gaps = 31/351 (8%)
Query: 27 LELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE 86
++++ L + DF + R+IGRG + +V R ++YAMK + K+ + + E
Sbjct: 241 IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE 300
Query: 87 RIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYA 146
+ + S+ PF+V + F T +L +++ +NGGDL +H+ + E +FYA
Sbjct: 301 KHVFEQASSN---PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYA 357
Query: 147 AEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGY 204
AE+ + L +H+R I+YRDLK N+LLD GH++++D G+ + S GT Y
Sbjct: 358 AEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNY 417
Query: 205 MAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXX 264
+APE+L +G Y S DW++ G ++++++ G SPF D +T N
Sbjct: 418 IAPEIL-RGEEYGFSVDWWALGVLMFEMMAGRSPF-----------DIITDNPDMNTEDY 465
Query: 265 XXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGR-GADEVKEHVFF 323
+ E +P S +L+G L +D +RLGC+ + G ++K H FF
Sbjct: 466 LF-------QVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFF 518
Query: 324 AGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT-KGIKLTETDQ 373
IDW + ++ PP P D + + +FD + T + ++LT D+
Sbjct: 519 RSIDWDLLEKKQALPPFQP-----QITDDYGLDNFDTQFTSEPVQLTPDDE 564
>BC014270-1|AAH14270.1| 592|Homo sapiens protein kinase C, zeta
protein.
Length = 592
Score = 165 bits (400), Expect = 5e-40
Identities = 102/351 (29%), Positives = 176/351 (50%), Gaps = 31/351 (8%)
Query: 27 LELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE 86
++++ L + DF + R+IGRG + +V R ++YAMK + K+ + + E
Sbjct: 241 IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE 300
Query: 87 RIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYA 146
+ + S+ PF+V + F T +L +++ +NGGDL +H+ + E +FYA
Sbjct: 301 KHVFEQASSN---PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYA 357
Query: 147 AEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGY 204
AE+ + L +H+R I+YRDLK N+LLD GH++++D G+ + S GT Y
Sbjct: 358 AEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNY 417
Query: 205 MAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXX 264
+APE+L +G Y S DW++ G ++++++ G SPF D +T N
Sbjct: 418 IAPEIL-RGEEYGFSVDWWALGVLMFEMMAGRSPF-----------DIITDNPDMNTEDY 465
Query: 265 XXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGR-GADEVKEHVFF 323
+ E +P S +L+G L +D +RLGC+ + G ++K H FF
Sbjct: 466 LF-------QVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFF 518
Query: 324 AGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT-KGIKLTETDQ 373
IDW + ++ PP P D + + +FD + T + ++LT D+
Sbjct: 519 RSIDWDLLEKKQALPPFQP-----QITDDYGLDNFDTQFTSEPVQLTPDDE 564
>BC008058-1|AAH08058.1| 592|Homo sapiens protein kinase C, zeta
protein.
Length = 592
Score = 165 bits (400), Expect = 5e-40
Identities = 102/351 (29%), Positives = 176/351 (50%), Gaps = 31/351 (8%)
Query: 27 LELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE 86
++++ L + DF + R+IGRG + +V R ++YAMK + K+ + + E
Sbjct: 241 IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE 300
Query: 87 RIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYA 146
+ + S+ PF+V + F T +L +++ +NGGDL +H+ + E +FYA
Sbjct: 301 KHVFEQASSN---PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYA 357
Query: 147 AEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGY 204
AE+ + L +H+R I+YRDLK N+LLD GH++++D G+ + S GT Y
Sbjct: 358 AEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNY 417
Query: 205 MAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXX 264
+APE+L +G Y S DW++ G ++++++ G SPF D +T N
Sbjct: 418 IAPEIL-RGEEYGFSVDWWALGVLMFEMMAGRSPF-----------DIITDNPDMNTEDY 465
Query: 265 XXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGR-GADEVKEHVFF 323
+ E +P S +L+G L +D +RLGC+ + G ++K H FF
Sbjct: 466 LF-------QVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFF 518
Query: 324 AGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT-KGIKLTETDQ 373
IDW + ++ PP P D + + +FD + T + ++LT D+
Sbjct: 519 RSIDWDLLEKKQALPPFQP-----QITDDYGLDNFDTQFTSEPVQLTPDDE 564
>AL645703-1|CAI21535.1| 592|Homo sapiens protein kinase C, zeta
protein.
Length = 592
Score = 165 bits (400), Expect = 5e-40
Identities = 102/351 (29%), Positives = 176/351 (50%), Gaps = 31/351 (8%)
Query: 27 LELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE 86
++++ L + DF + R+IGRG + +V R ++YAMK + K+ + + E
Sbjct: 241 IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE 300
Query: 87 RIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYA 146
+ + S+ PF+V + F T +L +++ +NGGDL +H+ + E +FYA
Sbjct: 301 KHVFEQASSN---PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYA 357
Query: 147 AEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGY 204
AE+ + L +H+R I+YRDLK N+LLD GH++++D G+ + S GT Y
Sbjct: 358 AEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNY 417
Query: 205 MAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXX 264
+APE+L +G Y S DW++ G ++++++ G SPF D +T N
Sbjct: 418 IAPEIL-RGEEYGFSVDWWALGVLMFEMMAGRSPF-----------DIITDNPDMNTEDY 465
Query: 265 XXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGR-GADEVKEHVFF 323
+ E +P S +L+G L +D +RLGC+ + G ++K H FF
Sbjct: 466 LF-------QVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFF 518
Query: 324 AGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT-KGIKLTETDQ 373
IDW + ++ PP P D + + +FD + T + ++LT D+
Sbjct: 519 RSIDWDLLEKKQALPPFQP-----QITDDYGLDNFDTQFTSEPVQLTPDDE 564
>AL590822-6|CAI12484.1| 592|Homo sapiens protein kinase C, zeta
protein.
Length = 592
Score = 165 bits (400), Expect = 5e-40
Identities = 102/351 (29%), Positives = 176/351 (50%), Gaps = 31/351 (8%)
Query: 27 LELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE 86
++++ L + DF + R+IGRG + +V R ++YAMK + K+ + + E
Sbjct: 241 IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE 300
Query: 87 RIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYA 146
+ + S+ PF+V + F T +L +++ +NGGDL +H+ + E +FYA
Sbjct: 301 KHVFEQASSN---PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYA 357
Query: 147 AEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGY 204
AE+ + L +H+R I+YRDLK N+LLD GH++++D G+ + S GT Y
Sbjct: 358 AEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNY 417
Query: 205 MAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXX 264
+APE+L +G Y S DW++ G ++++++ G SPF D +T N
Sbjct: 418 IAPEIL-RGEEYGFSVDWWALGVLMFEMMAGRSPF-----------DIITDNPDMNTEDY 465
Query: 265 XXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGR-GADEVKEHVFF 323
+ E +P S +L+G L +D +RLGC+ + G ++K H FF
Sbjct: 466 LF-------QVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFF 518
Query: 324 AGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT-KGIKLTETDQ 373
IDW + ++ PP P D + + +FD + T + ++LT D+
Sbjct: 519 RSIDWDLLEKKQALPPFQP-----QITDDYGLDNFDTQFTSEPVQLTPDDE 564
>AL391845-5|CAI15438.1| 592|Homo sapiens protein kinase C, zeta
protein.
Length = 592
Score = 165 bits (400), Expect = 5e-40
Identities = 102/351 (29%), Positives = 176/351 (50%), Gaps = 31/351 (8%)
Query: 27 LELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE 86
++++ L + DF + R+IGRG + +V R ++YAMK + K+ + + E
Sbjct: 241 IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE 300
Query: 87 RIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYA 146
+ + S+ PF+V + F T +L +++ +NGGDL +H+ + E +FYA
Sbjct: 301 KHVFEQASSN---PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYA 357
Query: 147 AEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGY 204
AE+ + L +H+R I+YRDLK N+LLD GH++++D G+ + S GT Y
Sbjct: 358 AEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNY 417
Query: 205 MAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXX 264
+APE+L +G Y S DW++ G ++++++ G SPF D +T N
Sbjct: 418 IAPEIL-RGEEYGFSVDWWALGVLMFEMMAGRSPF-----------DIITDNPDMNTEDY 465
Query: 265 XXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGR-GADEVKEHVFF 323
+ E +P S +L+G L +D +RLGC+ + G ++K H FF
Sbjct: 466 LF-------QVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFF 518
Query: 324 AGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT-KGIKLTETDQ 373
IDW + ++ PP P D + + +FD + T + ++LT D+
Sbjct: 519 RSIDWDLLEKKQALPPFQP-----QITDDYGLDNFDTQFTSEPVQLTPDDE 564
>L14283-1|AAA36488.1| 592|Homo sapiens protein kinase C zeta
protein.
Length = 592
Score = 164 bits (398), Expect = 9e-40
Identities = 102/351 (29%), Positives = 176/351 (50%), Gaps = 31/351 (8%)
Query: 27 LELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE 86
++++ L + DF + R+IGRG + +V R ++YAMK + K+ + + E
Sbjct: 241 IKISQGLGLQDFDLIRVIGRGTYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE 300
Query: 87 RIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYA 146
+ + S+ PF+V + F T +L +++ +NGGDL +H+ + E +FYA
Sbjct: 301 KHVFEQASSN---PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYA 357
Query: 147 AEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGY 204
AE+ + L +H+R I+YRDLK N+LLD GH++++D G+ + S GT Y
Sbjct: 358 AEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNY 417
Query: 205 MAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXX 264
+APE+L +G Y S DW++ G ++++++ G SPF D +T N
Sbjct: 418 IAPEIL-RGEEYGFSVDWWALGVLMFEMMAGRSPF-----------DIITDNPDMNTEDY 465
Query: 265 XXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGR-GADEVKEHVFF 323
+ E +P S +L+G L +D +RLGC+ + G ++K H FF
Sbjct: 466 LF-------QVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFF 518
Query: 324 AGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDEEDT-KGIKLTETDQ 373
IDW + ++ PP P D + + +FD + T + ++LT D+
Sbjct: 519 RSIDWDLLEKKQALPPFQP-----QITDDYGLDNFDTQFTSEPVQLTPDDE 564
>BC020479-1|AAH20479.1| 466|Homo sapiens AKT3 protein protein.
Length = 466
Score = 163 bits (397), Expect = 1e-39
Identities = 82/208 (39%), Positives = 124/208 (59%), Gaps = 7/208 (3%)
Query: 34 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 93
TMNDF +++G+G FG+V R+ +GK YAMK L K+ I K L E S V
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTE----SRV 199
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
PF+ + Y+F T D+LCF+++ +NGG+L +HLS+ VF+E +FY AE++ L
Sbjct: 200 LKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSAL 259
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLS 211
+++H IVYRDLK N++LD+ GH++I+D GL + GT Y+APEVL
Sbjct: 260 DYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVL- 318
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPF 239
+ Y + DW+ G ++Y+++ G PF
Sbjct: 319 EDNDYGRAVDWWGLGVVMYEMMCGRLPF 346
Score = 64.9 bits (151), Expect = 7e-10
Identities = 39/104 (37%), Positives = 52/104 (50%), Gaps = 6/104 (5%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P + S KSLL GLL +D NKRLG A E+ H FF+G++WQ VY +K PP P
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP- 424
Query: 344 RGEVNAADAFDIGSFDEEDT-KGIKLTETDQMQYKDFPLVISER 386
D FDEE T + I +T ++ + +ER
Sbjct: 425 ----QVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNER 464
>AY005799-1|AAF91073.1| 465|Homo sapiens protein kinase B gamma 1
protein.
Length = 465
Score = 163 bits (397), Expect = 1e-39
Identities = 82/208 (39%), Positives = 124/208 (59%), Gaps = 7/208 (3%)
Query: 34 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 93
TMNDF +++G+G FG+V R+ +GK YAMK L K+ I K L E S V
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTE----SRV 199
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
PF+ + Y+F T D+LCF+++ +NGG+L +HLS+ VF+E +FY AE++ L
Sbjct: 200 LKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSAL 259
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLS 211
+++H IVYRDLK N++LD+ GH++I+D GL + GT Y+APEVL
Sbjct: 260 DYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVL- 318
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPF 239
+ Y + DW+ G ++Y+++ G PF
Sbjct: 319 EDNDYGRAVDWWGLGVVMYEMMCGRLPF 346
Score = 67.7 bits (158), Expect = 1e-10
Identities = 39/96 (40%), Positives = 50/96 (52%), Gaps = 6/96 (6%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P + S KSLL GLL +D NKRLG A E+ H FF+G++WQ VY +K PP P
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP- 424
Query: 344 RGEVNAADAFDIGSFDEEDT-KGIKLTETDQMQYKD 378
D FDEE T + I +T ++ Q D
Sbjct: 425 ----QVTSETDTRYFDEEFTAQTITITPPEKCQQSD 456
>AL662889-3|CAH73073.1| 479|Homo sapiens v-akt murine thymoma viral
oncogene homolog 3 (protein kinase B, gamma) protein.
Length = 479
Score = 163 bits (397), Expect = 1e-39
Identities = 82/208 (39%), Positives = 124/208 (59%), Gaps = 7/208 (3%)
Query: 34 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 93
TMNDF +++G+G FG+V R+ +GK YAMK L K+ I K L E S V
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTE----SRV 199
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
PF+ + Y+F T D+LCF+++ +NGG+L +HLS+ VF+E +FY AE++ L
Sbjct: 200 LKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSAL 259
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLS 211
+++H IVYRDLK N++LD+ GH++I+D GL + GT Y+APEVL
Sbjct: 260 DYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVL- 318
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPF 239
+ Y + DW+ G ++Y+++ G PF
Sbjct: 319 EDNDYGRAVDWWGLGVVMYEMMCGRLPF 346
Score = 64.9 bits (151), Expect = 7e-10
Identities = 39/104 (37%), Positives = 52/104 (50%), Gaps = 6/104 (5%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P + S KSLL GLL +D NKRLG A E+ H FF+G++WQ VY +K PP P
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP- 424
Query: 344 RGEVNAADAFDIGSFDEEDT-KGIKLTETDQMQYKDFPLVISER 386
D FDEE T + I +T ++ + +ER
Sbjct: 425 ----QVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNER 464
>AL662889-2|CAH73072.1| 465|Homo sapiens v-akt murine thymoma viral
oncogene homolog 3 (protein kinase B, gamma) protein.
Length = 465
Score = 163 bits (397), Expect = 1e-39
Identities = 82/208 (39%), Positives = 124/208 (59%), Gaps = 7/208 (3%)
Query: 34 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 93
TMNDF +++G+G FG+V R+ +GK YAMK L K+ I K L E S V
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTE----SRV 199
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
PF+ + Y+F T D+LCF+++ +NGG+L +HLS+ VF+E +FY AE++ L
Sbjct: 200 LKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSAL 259
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLS 211
+++H IVYRDLK N++LD+ GH++I+D GL + GT Y+APEVL
Sbjct: 260 DYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVL- 318
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPF 239
+ Y + DW+ G ++Y+++ G PF
Sbjct: 319 EDNDYGRAVDWWGLGVVMYEMMCGRLPF 346
Score = 67.7 bits (158), Expect = 1e-10
Identities = 39/96 (40%), Positives = 50/96 (52%), Gaps = 6/96 (6%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P + S KSLL GLL +D NKRLG A E+ H FF+G++WQ VY +K PP P
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP- 424
Query: 344 RGEVNAADAFDIGSFDEEDT-KGIKLTETDQMQYKD 378
D FDEE T + I +T ++ Q D
Sbjct: 425 ----QVTSETDTRYFDEEFTAQTITITPPEKCQQSD 456
>AL592151-2|CAH72892.1| 479|Homo sapiens v-akt murine thymoma viral
oncogene homolog 3 (protein kinase B, gamma) protein.
Length = 479
Score = 163 bits (397), Expect = 1e-39
Identities = 82/208 (39%), Positives = 124/208 (59%), Gaps = 7/208 (3%)
Query: 34 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 93
TMNDF +++G+G FG+V R+ +GK YAMK L K+ I K L E S V
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTE----SRV 199
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
PF+ + Y+F T D+LCF+++ +NGG+L +HLS+ VF+E +FY AE++ L
Sbjct: 200 LKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSAL 259
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLS 211
+++H IVYRDLK N++LD+ GH++I+D GL + GT Y+APEVL
Sbjct: 260 DYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVL- 318
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPF 239
+ Y + DW+ G ++Y+++ G PF
Sbjct: 319 EDNDYGRAVDWWGLGVVMYEMMCGRLPF 346
Score = 64.9 bits (151), Expect = 7e-10
Identities = 39/104 (37%), Positives = 52/104 (50%), Gaps = 6/104 (5%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P + S KSLL GLL +D NKRLG A E+ H FF+G++WQ VY +K PP P
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP- 424
Query: 344 RGEVNAADAFDIGSFDEEDT-KGIKLTETDQMQYKDFPLVISER 386
D FDEE T + I +T ++ + +ER
Sbjct: 425 ----QVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNER 464
>AL592151-1|CAH72891.1| 465|Homo sapiens v-akt murine thymoma viral
oncogene homolog 3 (protein kinase B, gamma) protein.
Length = 465
Score = 163 bits (397), Expect = 1e-39
Identities = 82/208 (39%), Positives = 124/208 (59%), Gaps = 7/208 (3%)
Query: 34 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 93
TMNDF +++G+G FG+V R+ +GK YAMK L K+ I K L E S V
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTE----SRV 199
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
PF+ + Y+F T D+LCF+++ +NGG+L +HLS+ VF+E +FY AE++ L
Sbjct: 200 LKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSAL 259
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLS 211
+++H IVYRDLK N++LD+ GH++I+D GL + GT Y+APEVL
Sbjct: 260 DYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVL- 318
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPF 239
+ Y + DW+ G ++Y+++ G PF
Sbjct: 319 EDNDYGRAVDWWGLGVVMYEMMCGRLPF 346
Score = 67.7 bits (158), Expect = 1e-10
Identities = 39/96 (40%), Positives = 50/96 (52%), Gaps = 6/96 (6%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P + S KSLL GLL +D NKRLG A E+ H FF+G++WQ VY +K PP P
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP- 424
Query: 344 RGEVNAADAFDIGSFDEEDT-KGIKLTETDQMQYKD 378
D FDEE T + I +T ++ Q D
Sbjct: 425 ----QVTSETDTRYFDEEFTAQTITITPPEKCQQSD 456
>AL591721-2|CAH71867.1| 479|Homo sapiens v-akt murine thymoma viral
oncogene homolog 3 (protein kinase B, gamma) protein.
Length = 479
Score = 163 bits (397), Expect = 1e-39
Identities = 82/208 (39%), Positives = 124/208 (59%), Gaps = 7/208 (3%)
Query: 34 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 93
TMNDF +++G+G FG+V R+ +GK YAMK L K+ I K L E S V
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTE----SRV 199
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
PF+ + Y+F T D+LCF+++ +NGG+L +HLS+ VF+E +FY AE++ L
Sbjct: 200 LKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSAL 259
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLS 211
+++H IVYRDLK N++LD+ GH++I+D GL + GT Y+APEVL
Sbjct: 260 DYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVL- 318
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPF 239
+ Y + DW+ G ++Y+++ G PF
Sbjct: 319 EDNDYGRAVDWWGLGVVMYEMMCGRLPF 346
Score = 64.9 bits (151), Expect = 7e-10
Identities = 39/104 (37%), Positives = 52/104 (50%), Gaps = 6/104 (5%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P + S KSLL GLL +D NKRLG A E+ H FF+G++WQ VY +K PP P
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP- 424
Query: 344 RGEVNAADAFDIGSFDEEDT-KGIKLTETDQMQYKDFPLVISER 386
D FDEE T + I +T ++ + +ER
Sbjct: 425 ----QVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNER 464
>AL591721-1|CAH71866.1| 465|Homo sapiens v-akt murine thymoma viral
oncogene homolog 3 (protein kinase B, gamma) protein.
Length = 465
Score = 163 bits (397), Expect = 1e-39
Identities = 82/208 (39%), Positives = 124/208 (59%), Gaps = 7/208 (3%)
Query: 34 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 93
TMNDF +++G+G FG+V R+ +GK YAMK L K+ I K L E S V
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTE----SRV 199
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
PF+ + Y+F T D+LCF+++ +NGG+L +HLS+ VF+E +FY AE++ L
Sbjct: 200 LKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSAL 259
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLS 211
+++H IVYRDLK N++LD+ GH++I+D GL + GT Y+APEVL
Sbjct: 260 DYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVL- 318
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPF 239
+ Y + DW+ G ++Y+++ G PF
Sbjct: 319 EDNDYGRAVDWWGLGVVMYEMMCGRLPF 346
Score = 67.7 bits (158), Expect = 1e-10
Identities = 39/96 (40%), Positives = 50/96 (52%), Gaps = 6/96 (6%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P + S KSLL GLL +D NKRLG A E+ H FF+G++WQ VY +K PP P
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP- 424
Query: 344 RGEVNAADAFDIGSFDEEDT-KGIKLTETDQMQYKD 378
D FDEE T + I +T ++ Q D
Sbjct: 425 ----QVTSETDTRYFDEEFTAQTITITPPEKCQQSD 456
>AJ245709-1|CAB53537.1| 479|Homo sapiens Akt-3 protein protein.
Length = 479
Score = 163 bits (397), Expect = 1e-39
Identities = 82/208 (39%), Positives = 124/208 (59%), Gaps = 7/208 (3%)
Query: 34 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 93
TMNDF +++G+G FG+V R+ +GK YAMK L K+ I K L E S V
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTE----SRV 199
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
PF+ + Y+F T D+LCF+++ +NGG+L +HLS+ VF+E +FY AE++ L
Sbjct: 200 LKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSAL 259
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLS 211
+++H IVYRDLK N++LD+ GH++I+D GL + GT Y+APEVL
Sbjct: 260 DYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVL- 318
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPF 239
+ Y + DW+ G ++Y+++ G PF
Sbjct: 319 EDNDYGRAVDWWGLGVVMYEMMCGRLPF 346
Score = 64.9 bits (151), Expect = 7e-10
Identities = 39/104 (37%), Positives = 52/104 (50%), Gaps = 6/104 (5%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P + S KSLL GLL +D NKRLG A E+ H FF+G++WQ VY +K PP P
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP- 424
Query: 344 RGEVNAADAFDIGSFDEEDT-KGIKLTETDQMQYKDFPLVISER 386
D FDEE T + I +T ++ + +ER
Sbjct: 425 ----QVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNER 464
>AF135794-1|AAD24196.1| 479|Homo sapiens AKT3 protein kinase
protein.
Length = 479
Score = 163 bits (397), Expect = 1e-39
Identities = 82/208 (39%), Positives = 124/208 (59%), Gaps = 7/208 (3%)
Query: 34 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 93
TMNDF +++G+G FG+V R+ +GK YAMK L K+ I K L E S V
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTE----SRV 199
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
PF+ + Y+F T D+LCF+++ +NGG+L +HLS+ VF+E +FY AE++ L
Sbjct: 200 LKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSAL 259
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLS 211
+++H IVYRDLK N++LD+ GH++I+D GL + GT Y+APEVL
Sbjct: 260 DYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVL- 318
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPF 239
+ Y + DW+ G ++Y+++ G PF
Sbjct: 319 EDNDYGRAVDWWGLGVVMYEMMCGRLPF 346
Score = 64.9 bits (151), Expect = 7e-10
Identities = 39/104 (37%), Positives = 52/104 (50%), Gaps = 6/104 (5%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P + S KSLL GLL +D NKRLG A E+ H FF+G++WQ VY +K PP P
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP- 424
Query: 344 RGEVNAADAFDIGSFDEEDT-KGIKLTETDQMQYKDFPLVISER 386
D FDEE T + I +T ++ + +ER
Sbjct: 425 ----QVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNER 464
>AF124141-1|AAD29089.1| 479|Homo sapiens protein kinase B gamma
protein.
Length = 479
Score = 163 bits (397), Expect = 1e-39
Identities = 82/208 (39%), Positives = 124/208 (59%), Gaps = 7/208 (3%)
Query: 34 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 93
TMNDF +++G+G FG+V R+ +GK YAMK L K+ I K L E S V
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTE----SRV 199
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
PF+ + Y+F T D+LCF+++ +NGG+L +HLS+ VF+E +FY AE++ L
Sbjct: 200 LKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSAL 259
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLS 211
+++H IVYRDLK N++LD+ GH++I+D GL + GT Y+APEVL
Sbjct: 260 DYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVL- 318
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPF 239
+ Y + DW+ G ++Y+++ G PF
Sbjct: 319 EDNDYGRAVDWWGLGVVMYEMMCGRLPF 346
Score = 64.9 bits (151), Expect = 7e-10
Identities = 39/104 (37%), Positives = 52/104 (50%), Gaps = 6/104 (5%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P + S KSLL GLL +D NKRLG A E+ H FF+G++WQ VY +K PP P
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP- 424
Query: 344 RGEVNAADAFDIGSFDEEDT-KGIKLTETDQMQYKDFPLVISER 386
D FDEE T + I +T ++ + +ER
Sbjct: 425 ----QVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNER 464
>AF085234-1|AAL40392.1| 479|Homo sapiens STK-2 protein.
Length = 479
Score = 163 bits (397), Expect = 1e-39
Identities = 82/208 (39%), Positives = 124/208 (59%), Gaps = 7/208 (3%)
Query: 34 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 93
TMNDF +++G+G FG+V R+ +GK YAMK L K+ I K L E S V
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTE----SRV 199
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
PF+ + Y+F T D+LCF+++ +NGG+L +HLS+ VF+E +FY AE++ L
Sbjct: 200 LKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSAL 259
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLS 211
+++H IVYRDLK N++LD+ GH++I+D GL + GT Y+APEVL
Sbjct: 260 DYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVL- 318
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPF 239
+ Y + DW+ G ++Y+++ G PF
Sbjct: 319 EDNDYGRAVDWWGLGVVMYEMMCGRLPF 346
Score = 64.9 bits (151), Expect = 7e-10
Identities = 39/104 (37%), Positives = 52/104 (50%), Gaps = 6/104 (5%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P + S KSLL GLL +D NKRLG A E+ H FF+G++WQ VY +K PP P
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP- 424
Query: 344 RGEVNAADAFDIGSFDEEDT-KGIKLTETDQMQYKDFPLVISER 386
D FDEE T + I +T ++ + +ER
Sbjct: 425 ----QVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNER 464
>L07861-1|AAA03175.1| 676|Homo sapiens protein kinase C-delta 13
protein.
Length = 676
Score = 163 bits (396), Expect = 1e-39
Identities = 109/352 (30%), Positives = 171/352 (48%), Gaps = 45/352 (12%)
Query: 35 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 94
+N+F H+++G+G FG+V G+ +A+K L K + + + E+ +L+L +
Sbjct: 346 INNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAA 405
Query: 95 TGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLE 154
PF+ + F T D L F+++ +NGGDL YH+ G F FYAAE++ GL+
Sbjct: 406 EN---PFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQ 462
Query: 155 HMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLSK 212
+H + I+YRDLK N+LLD GH++I+D G+ + F + + GT Y+APE+L +
Sbjct: 463 FLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEIL-Q 521
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXA 272
G Y S DW+SFG +LY++L G SPF D+ E+
Sbjct: 522 GLKYTFSVDWWSFGVLLYEMLIGQSPFH---GDDEDEL------------------FESI 560
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+ R + + L+ L E R+ KRLG G +K H FF I+W +
Sbjct: 561 RVDTPHYPRWITKESKDILEKLFE----REPTKRLGVTG----NIKIHPFFKTINWTLLE 612
Query: 333 HQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDFPLVIS 384
++ PP P D +FD+E L E ++ Y D L+ S
Sbjct: 613 KRRLEPPFRP-----KVKSPRDYSNFDQE-----FLNEKARLSYSDKNLIDS 654
>D10495-1|BAA01381.1| 626|Homo sapiens protein kinase C delta-type
protein.
Length = 626
Score = 163 bits (396), Expect = 1e-39
Identities = 109/352 (30%), Positives = 171/352 (48%), Gaps = 45/352 (12%)
Query: 35 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 94
+N+F H+++G+G FG+V G+ +A+K L K + + + E+ +L+L +
Sbjct: 296 INNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAA 355
Query: 95 TGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLE 154
PF+ + F T D L F+++ +NGGDL YH+ G F FYAAE++ GL+
Sbjct: 356 EN---PFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQ 412
Query: 155 HMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLSK 212
+H + I+YRDLK N+LLD GH++I+D G+ + F + + GT Y+APE+L +
Sbjct: 413 FLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEIL-Q 471
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXA 272
G Y S DW+SFG +LY++L G SPF D+ E+
Sbjct: 472 GLKYTFSVDWWSFGVLLYEMLIGQSPFH---GDDEDEL------------------FESI 510
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+ R + + L+ L E R+ KRLG G +K H FF I+W +
Sbjct: 511 RVDTPHYPRWITKESKDILEKLFE----REPTKRLGVTG----NIKIHPFFKTINWTLLE 562
Query: 333 HQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDFPLVIS 384
++ PP P D +FD+E L E ++ Y D L+ S
Sbjct: 563 KRRLEPPFRP-----KVKSPRDYSNFDQE-----FLNEKARLSYSDKNLIDS 604
>BC043350-1|AAH43350.1| 676|Homo sapiens protein kinase C, delta
protein.
Length = 676
Score = 163 bits (396), Expect = 1e-39
Identities = 109/352 (30%), Positives = 171/352 (48%), Gaps = 45/352 (12%)
Query: 35 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 94
+N+F H+++G+G FG+V G+ +A+K L K + + + E+ +L+L +
Sbjct: 346 INNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAA 405
Query: 95 TGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLE 154
PF+ + F T D L F+++ +NGGDL YH+ G F FYAAE++ GL+
Sbjct: 406 EN---PFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQ 462
Query: 155 HMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLSK 212
+H + I+YRDLK N+LLD GH++I+D G+ + F + + GT Y+APE+L +
Sbjct: 463 FLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEIL-Q 521
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXA 272
G Y S DW+SFG +LY++L G SPF D+ E+
Sbjct: 522 GLKYTFSVDWWSFGVLLYEMLIGQSPFH---GDDEDEL------------------FESI 560
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+ R + + L+ L E R+ KRLG G +K H FF I+W +
Sbjct: 561 RVDTPHYPRWITKESKDILEKLFE----REPTKRLGVTG----NIKIHPFFKTINWTLLE 612
Query: 333 HQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDFPLVIS 384
++ PP P D +FD+E L E ++ Y D L+ S
Sbjct: 613 KRRLEPPFRP-----KVKSPRDYSNFDQE-----FLNEKARLSYSDKNLIDS 654
>L07860-1|AAA03176.1| 676|Homo sapiens protein kinase C-delta 13
protein.
Length = 676
Score = 161 bits (391), Expect = 6e-39
Identities = 109/352 (30%), Positives = 170/352 (48%), Gaps = 45/352 (12%)
Query: 35 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 94
+N+F H+++G+G FG+V G+ A+K L K + + + E+ +L+L +
Sbjct: 346 INNFIFHKVLGKGSFGKVLLGELKGRGEYSAIKALKKDVVLIDDDVECTMVEKRVLTLAA 405
Query: 95 TGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLE 154
PF+ + F T D L F+++ +NGGDL YH+ G F FYAAE++ GL+
Sbjct: 406 EN---PFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQ 462
Query: 155 HMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLSK 212
+H + I+YRDLK N+LLD GH++I+D G+ + F + + GT Y+APE+L +
Sbjct: 463 FLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEIL-Q 521
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXA 272
G Y S DW+SFG +LY++L G SPF D+ E+
Sbjct: 522 GLKYTFSVDWWSFGVLLYEMLIGQSPFH---GDDEDEL------------------FESI 560
Query: 273 STTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVY 332
+ R + + L+ L E R+ KRLG G +K H FF I+W +
Sbjct: 561 RVDTPHYPRWITKESKDILEKLFE----REPTKRLGMTG----NIKIHPFFKTINWTLLE 612
Query: 333 HQKYTPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDFPLVIS 384
++ PP P D +FD+E L E ++ Y D L+ S
Sbjct: 613 KRRLEPPFRP-----KVKSPRDYSNFDQE-----FLNEKARLSYSDKNLIDS 654
>BC121154-1|AAI21155.1| 465|Homo sapiens v-akt murine thymoma viral
oncogene homolog 3 (protein kinase B, gamma) protein.
Length = 465
Score = 161 bits (391), Expect = 6e-39
Identities = 81/208 (38%), Positives = 123/208 (59%), Gaps = 7/208 (3%)
Query: 34 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 93
TMNDF +++G+G FG+V R+ +GK YAMK L K+ I K L E S V
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTE----SRV 199
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
PF+ + Y+F T D+LCF+++ +NGG+L +HLS+ VF+E +FY AE++ L
Sbjct: 200 LKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSAL 259
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLS 211
+++H IVYRDLK N++ D+ GH++I+D GL + GT Y+APEVL
Sbjct: 260 DYLHSGKIVYRDLKLENLMRDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVL- 318
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPF 239
+ Y + DW+ G ++Y+++ G PF
Sbjct: 319 EDNDYGRAVDWWGLGVVMYEMMCGRLPF 346
Score = 67.7 bits (158), Expect = 1e-10
Identities = 39/96 (40%), Positives = 50/96 (52%), Gaps = 6/96 (6%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P + S KSLL GLL +D NKRLG A E+ H FF+G++WQ VY +K PP P
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP- 424
Query: 344 RGEVNAADAFDIGSFDEEDT-KGIKLTETDQMQYKD 378
D FDEE T + I +T ++ Q D
Sbjct: 425 ----QVTSETDTRYFDEEFTAQTITITPPEKCQQSD 456
>BC032709-1|AAH32709.1| 344|Homo sapiens Unknown (protein for
IMAGE:5496641) protein.
Length = 344
Score = 160 bits (389), Expect = 1e-38
Identities = 79/204 (38%), Positives = 122/204 (59%), Gaps = 7/204 (3%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
++TMNDF +++G+G FG+V R+ TG+ YAMK L K+ I K + E S
Sbjct: 146 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTE----S 201
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
V PF+ + YAF T D+LCF+++ NGG+L +HLS+ VF E +FY AE++
Sbjct: 202 RVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVS 261
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEV 209
LE++H R +VYRD+K N++LD+ GH++I+D GL + GT Y+APEV
Sbjct: 262 ALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEV 321
Query: 210 LSKGTGYDSSADWFSFGCMLYKLL 233
L + Y + DW+ G ++Y+++
Sbjct: 322 L-EDNDYGRAVDWWGLGVVMYEMM 344
>AL807772-1|CAI39684.1| 227|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 3 protein.
Length = 227
Score = 160 bits (389), Expect = 1e-38
Identities = 83/196 (42%), Positives = 126/196 (64%), Gaps = 11/196 (5%)
Query: 36 NDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
+ F + +++G+G FG+V+ +K +D ++YAMK L K +K++ + I++
Sbjct: 37 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVE- 95
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
V+ PFIV + YAF T KL ILD + GGDL LS+ +F E ++KFY AE+ L
Sbjct: 96 ----VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 151
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVL 210
L+H+H I+YRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+
Sbjct: 152 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 211
Query: 211 SKGTGYDSSADWFSFG 226
++ G+ SADW+SFG
Sbjct: 212 NR-RGHTQSADWWSFG 226
>CR536581-1|CAG38818.1| 429|Homo sapiens SGKL protein.
Length = 429
Score = 157 bits (382), Expect = 7e-38
Identities = 83/205 (40%), Positives = 123/205 (60%), Gaps = 6/205 (2%)
Query: 37 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 96
DF ++IG+G FG+V ++ GK YA+K L KK + ++ + + ER +++
Sbjct: 94 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAER---NVLLKN 150
Query: 97 VDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHM 156
V PF+V + Y+F T +KL F+LD +NGG+L +HL + F E +FYAAE+ L ++
Sbjct: 151 VKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYL 210
Query: 157 HKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKGT 214
H IVYRDLKP NILLD GHV ++D GL + + GT Y+APEV+ K
Sbjct: 211 HSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRK-Q 269
Query: 215 GYDSSADWFSFGCMLYKLLKGHSPF 239
YD++ DW+ G +LY++L G PF
Sbjct: 270 PYDNTVDWWCLGAVLYEMLYGLPPF 294
Score = 43.6 bits (98), Expect = 0.002
Identities = 26/72 (36%), Positives = 36/72 (50%), Gaps = 6/72 (8%)
Query: 293 SLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADA 352
S+LE LL++D RLG K E++ H FF + W + +K PP P N A
Sbjct: 323 SILEELLEKDRQNRLGAK-EDFLEIQNHPFFESLSWADLVQKKIPPPFNP-----NVAGP 376
Query: 353 FDIGSFDEEDTK 364
DI +FD T+
Sbjct: 377 DDIRNFDTAFTE 388
>BC015326-1|AAH15326.1| 496|Homo sapiens serum/glucocorticoid
regulated kinase family, member 3 protein.
Length = 496
Score = 157 bits (382), Expect = 7e-38
Identities = 83/205 (40%), Positives = 123/205 (60%), Gaps = 6/205 (2%)
Query: 37 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 96
DF ++IG+G FG+V ++ GK YA+K L KK + ++ + + ER +++
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAER---NVLLKN 217
Query: 97 VDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHM 156
V PF+V + Y+F T +KL F+LD +NGG+L +HL + F E +FYAAE+ L ++
Sbjct: 218 VKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYL 277
Query: 157 HKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKGT 214
H IVYRDLKP NILLD GHV ++D GL + + GT Y+APEV+ K
Sbjct: 278 HSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRK-Q 336
Query: 215 GYDSSADWFSFGCMLYKLLKGHSPF 239
YD++ DW+ G +LY++L G PF
Sbjct: 337 PYDNTVDWWCLGAVLYEMLYGLPPF 361
Score = 43.6 bits (98), Expect = 0.002
Identities = 26/72 (36%), Positives = 36/72 (50%), Gaps = 6/72 (8%)
Query: 293 SLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADA 352
S+LE LL++D RLG K E++ H FF + W + +K PP P N A
Sbjct: 390 SILEELLEKDRQNRLGAK-EDFLEIQNHPFFESLSWADLVQKKIPPPFNP-----NVAGP 443
Query: 353 FDIGSFDEEDTK 364
DI +FD T+
Sbjct: 444 DDIRNFDTAFTE 455
>AK223523-1|BAD97243.1| 496|Homo sapiens serum/glucocorticoid
regulated kinase-like isoform 1 variant protein.
Length = 496
Score = 157 bits (382), Expect = 7e-38
Identities = 83/205 (40%), Positives = 123/205 (60%), Gaps = 6/205 (2%)
Query: 37 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 96
DF ++IG+G FG+V ++ GK YA+K L KK + ++ + + ER +++
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAER---NVLLKN 217
Query: 97 VDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHM 156
V PF+V + Y+F T +KL F+LD +NGG+L +HL + F E +FYAAE+ L ++
Sbjct: 218 VKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYL 277
Query: 157 HKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKGT 214
H IVYRDLKP NILLD GHV ++D GL + + GT Y+APEV+ K
Sbjct: 278 HSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRK-Q 336
Query: 215 GYDSSADWFSFGCMLYKLLKGHSPF 239
YD++ DW+ G +LY++L G PF
Sbjct: 337 PYDNTVDWWCLGAVLYEMLYGLPPF 361
Score = 43.6 bits (98), Expect = 0.002
Identities = 26/72 (36%), Positives = 36/72 (50%), Gaps = 6/72 (8%)
Query: 293 SLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADA 352
S+LE LL++D RLG K E++ H FF + W + +K PP P N A
Sbjct: 390 SILEELLEKDRQNRLGAK-EDFLEIQNHPFFESLSWADLVQKKIPPPFNP-----NVAGP 443
Query: 353 FDIGSFDEEDTK 364
DI +FD T+
Sbjct: 444 DDIRNFDTAFTE 455
>AF169035-1|AAF12758.1| 429|Homo sapiens protein kinase protein.
Length = 429
Score = 157 bits (382), Expect = 7e-38
Identities = 83/205 (40%), Positives = 123/205 (60%), Gaps = 6/205 (2%)
Query: 37 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 96
DF ++IG+G FG+V ++ GK YA+K L KK + ++ + + ER +++
Sbjct: 94 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAER---NVLLKN 150
Query: 97 VDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHM 156
V PF+V + Y+F T +KL F+LD +NGG+L +HL + F E +FYAAE+ L ++
Sbjct: 151 VKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYL 210
Query: 157 HKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKGT 214
H IVYRDLKP NILLD GHV ++D GL + + GT Y+APEV+ K
Sbjct: 211 HSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRK-Q 269
Query: 215 GYDSSADWFSFGCMLYKLLKGHSPF 239
YD++ DW+ G +LY++L G PF
Sbjct: 270 PYDNTVDWWCLGAVLYEMLYGLPPF 294
Score = 43.6 bits (98), Expect = 0.002
Identities = 26/72 (36%), Positives = 36/72 (50%), Gaps = 6/72 (8%)
Query: 293 SLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADA 352
S+LE LL++D RLG K E++ H FF + W + +K PP P N A
Sbjct: 323 SILEELLEKDRQNRLGAK-EDFLEIQNHPFFESLSWADLVQKKIPPPFNP-----NVAGP 376
Query: 353 FDIGSFDEEDTK 364
DI +FD T+
Sbjct: 377 DDIRNFDTAFTE 388
>AF085233-1|AAF27051.2| 496|Homo sapiens SGK-like protein SGKL
protein.
Length = 496
Score = 157 bits (380), Expect = 1e-37
Identities = 82/205 (40%), Positives = 124/205 (60%), Gaps = 6/205 (2%)
Query: 37 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 96
DF ++IG+G FG+V ++ GK+YA+K L KK + ++ + + ER +++
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKVYAVKVLQKKIVLNRKEQKHIMAER---NVLLKN 217
Query: 97 VDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHM 156
V PF+V + Y+F T +KL F+LD +NGG+L +HL + F E +FYAAE+ L ++
Sbjct: 218 VKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYL 277
Query: 157 HKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLSKGT 214
H IVYRDLKP NIL+D GHV ++D GL + + GT Y+APEV+ K
Sbjct: 278 HSIKIVYRDLKPENILVDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRK-Q 336
Query: 215 GYDSSADWFSFGCMLYKLLKGHSPF 239
YD++ DW+ G +LY++L G PF
Sbjct: 337 PYDNTVDWWCLGAVLYEMLYGLPPF 361
Score = 43.6 bits (98), Expect = 0.002
Identities = 26/72 (36%), Positives = 36/72 (50%), Gaps = 6/72 (8%)
Query: 293 SLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADA 352
S+LE LL++D RLG K E++ H FF + W + +K PP P N A
Sbjct: 390 SILEELLEKDRQNRLGAK-EDFLEIQNHPFFESLSWADLVQKKIPPPFNP-----NVAGP 443
Query: 353 FDIGSFDEEDTK 364
DI +FD T+
Sbjct: 444 DDIRNFDTAFTE 455
>AY098866-1|AAM21719.1| 486|Homo sapiens PKE protein kinase
protein.
Length = 486
Score = 153 bits (371), Expect = 2e-36
Identities = 79/217 (36%), Positives = 126/217 (58%), Gaps = 9/217 (4%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
+ + F + R IG+G FG+V +K DT KMYAMK ++K++ + E +L
Sbjct: 88 VNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQ- 146
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
++ F+V + Y+F + + ++DL+ GGDL YHL Q+ F+E ++ Y E+ L
Sbjct: 147 ---EIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALA 203
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSK-KKPHASVGTHGYMAPEV-- 209
L+++ +HI++RD+KP NILLDE GH ++D +A ++ A GT YMAPE+
Sbjct: 204 LDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFH 263
Query: 210 --LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKT 244
++ GTGY DW+S G M Y+LL+G P+ H +
Sbjct: 264 SFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSS 300
>AL590105-1|CAI13011.1| 486|Homo sapiens protein kinase (PKE)
protein.
Length = 486
Score = 153 bits (371), Expect = 2e-36
Identities = 79/217 (36%), Positives = 126/217 (58%), Gaps = 9/217 (4%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
+ + F + R IG+G FG+V +K DT KMYAMK ++K++ + E +L
Sbjct: 88 VNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQ- 146
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
++ F+V + Y+F + + ++DL+ GGDL YHL Q+ F+E ++ Y E+ L
Sbjct: 147 ---EIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALA 203
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSK-KKPHASVGTHGYMAPEV-- 209
L+++ +HI++RD+KP NILLDE GH ++D +A ++ A GT YMAPE+
Sbjct: 204 LDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFH 263
Query: 210 --LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKT 244
++ GTGY DW+S G M Y+LL+G P+ H +
Sbjct: 264 SFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSS 300
>AL512622-1|CAI12181.1| 486|Homo sapiens protein kinase (PKE)
protein.
Length = 486
Score = 153 bits (371), Expect = 2e-36
Identities = 79/217 (36%), Positives = 126/217 (58%), Gaps = 9/217 (4%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 92
+ + F + R IG+G FG+V +K DT KMYAMK ++K++ + E +L
Sbjct: 88 VNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQ- 146
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
++ F+V + Y+F + + ++DL+ GGDL YHL Q+ F+E ++ Y E+ L
Sbjct: 147 ---EIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALA 203
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSK-KKPHASVGTHGYMAPEV-- 209
L+++ +HI++RD+KP NILLDE GH ++D +A ++ A GT YMAPE+
Sbjct: 204 LDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFH 263
Query: 210 --LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKT 244
++ GTGY DW+S G M Y+LL+G P+ H +
Sbjct: 264 SFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSS 300
>AL627313-4|CAI14647.1| 578|Homo sapiens ribosomal protein S6
kinase, 90kDa, polypeptide 1 protein.
Length = 578
Score = 152 bits (369), Expect = 3e-36
Identities = 89/251 (35%), Positives = 142/251 (56%), Gaps = 30/251 (11%)
Query: 136 VFNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF--SKK 193
+F E ++KFY AE+ LGL+H+H I+YRDLKP NILLDE GH++++D GL+ + +K
Sbjct: 1 MFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEK 60
Query: 194 KPHASVGTHGYMAPEVLSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKM 253
K ++ GT YMAPEV+++ G+ SADW+S+G +++++L G PF + KD+ E
Sbjct: 61 KAYSFCGTVEYMAPEVVNR-QGHSHSADWWSYGVLMFEMLTGSLPF---QGKDRKE---- 112
Query: 254 TLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRG 313
T+T++ + G+P+ S +SLL L +R+ RLG G
Sbjct: 113 TMTLILKA------------------KLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDG 154
Query: 314 ADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFD--IGSFDEEDTKGIKLTET 371
A+E+K HVF++ IDW ++Y ++ PP P + + FD S +D+ GI +
Sbjct: 155 AEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAG 214
Query: 372 DQMQYKDFPLV 382
++ F V
Sbjct: 215 AHQLFRGFSFV 225
Score = 89.0 bits (211), Expect = 4e-17
Identities = 67/219 (30%), Positives = 104/219 (47%), Gaps = 17/219 (7%)
Query: 38 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGV 97
+ V IG G + E C T YA+K +DK K E + + L+ G
Sbjct: 261 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKS--KRDPSEEIEI-------LLRYGQ 311
Query: 98 DCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHMH 157
P I+ + + + + +LM GG+L + + F+E E F + +E++H
Sbjct: 312 H-PNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLH 370
Query: 158 KRHIVYRDLKPANIL-LDEHGH---VRISDLGLACDFSKKKP--HASVGTHGYMAPEVLS 211
+ +V+RDLKP+NIL +DE G+ +RI D G A + T ++APEVL
Sbjct: 371 SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL- 429
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEI 250
K GYD D +S G +LY +L G++PF + EI
Sbjct: 430 KRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEI 468
>M34181-1|AAA60170.1| 351|Homo sapiens cAMP-dependent protein
kinase catalytic subunit protein.
Length = 351
Score = 151 bits (366), Expect = 6e-36
Identities = 80/219 (36%), Positives = 131/219 (59%), Gaps = 11/219 (5%)
Query: 23 QWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGET 81
+W+N N + DF + +G G FG V + T + YAMK LDK+++ K+KQ E
Sbjct: 30 KWENPTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEH 88
Query: 82 LALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAE 141
LNE+ +L V+ PF+V + YAF L +++ + GG++ HL + G F+E
Sbjct: 89 -TLNEKRILQ----AVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH 143
Query: 142 MKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGT 201
+FYAA+++L E++H ++YRDLKP N+L+D G+++++D G A K + GT
Sbjct: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA-KRVKGRTWTLCGT 202
Query: 202 HGYMAPE-VLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
Y+APE +LSK GY+ + DW++ G ++Y++ G+ PF
Sbjct: 203 PEYLAPEIILSK--GYNKAVDWWALGVLIYEMAAGYPPF 239
Score = 65.3 bits (152), Expect = 5e-10
Identities = 35/97 (36%), Positives = 51/97 (52%), Gaps = 5/97 (5%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P FS LK LL LLQ D+ KR G G ++K H +FA DW +Y +K P IP
Sbjct: 259 PSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPK 318
Query: 344 -RGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDF 379
RG + D + ++EED + + +TE ++ +F
Sbjct: 319 FRG---SGDTSNFDDYEEEDIR-VSITEKCAKEFGEF 351
>DQ667174-1|ABG25919.1| 398|Homo sapiens protein kinase,
cAMP-dependent, catalytic, beta protein.
Length = 398
Score = 151 bits (366), Expect = 6e-36
Identities = 80/219 (36%), Positives = 131/219 (59%), Gaps = 11/219 (5%)
Query: 23 QWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGET 81
+W+N N + DF + +G G FG V + T + YAMK LDK+++ K+KQ E
Sbjct: 77 KWENPTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEH 135
Query: 82 LALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAE 141
LNE+ +L V+ PF+V + YAF L +++ + GG++ HL + G F+E
Sbjct: 136 -TLNEKRILQ----AVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH 190
Query: 142 MKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGT 201
+FYAA+++L E++H ++YRDLKP N+L+D G+++++D G A K + GT
Sbjct: 191 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA-KRVKGRTWTLCGT 249
Query: 202 HGYMAPE-VLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
Y+APE +LSK GY+ + DW++ G ++Y++ G+ PF
Sbjct: 250 PEYLAPEIILSK--GYNKAVDWWALGVLIYEMAAGYPPF 286
Score = 65.3 bits (152), Expect = 5e-10
Identities = 35/97 (36%), Positives = 51/97 (52%), Gaps = 5/97 (5%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P FS LK LL LLQ D+ KR G G ++K H +FA DW +Y +K P IP
Sbjct: 306 PSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPK 365
Query: 344 -RGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDF 379
RG + D + ++EED + + +TE ++ +F
Sbjct: 366 FRG---SGDTSNFDDYEEEDIR-VSITEKCAKEFGEF 398
>BC016285-1|AAH16285.1| 257|Homo sapiens protein kinase,
cAMP-dependent, catalytic, beta protein.
Length = 257
Score = 151 bits (366), Expect = 6e-36
Identities = 80/219 (36%), Positives = 131/219 (59%), Gaps = 11/219 (5%)
Query: 23 QWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGET 81
+W+N N + DF + +G G FG V + T + YAMK LDK+++ K+KQ E
Sbjct: 30 KWENPTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEH 88
Query: 82 LALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAE 141
LNE+ +L V+ PF+V + YAF L +++ + GG++ HL + G F+E
Sbjct: 89 -TLNEKRILQ----AVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH 143
Query: 142 MKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGT 201
+FYAA+++L E++H ++YRDLKP N+L+D G+++++D G A K + GT
Sbjct: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA-KRVKGRTWTLCGT 202
Query: 202 HGYMAPE-VLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
Y+APE +LSK GY+ + DW++ G ++Y++ G+ PF
Sbjct: 203 PEYLAPEIILSK--GYNKAVDWWALGVLIYEMAAGYPPF 239
>AL450063-11|CAI16854.1| 264|Homo sapiens protein kinase,
cAMP-dependent, catalytic, beta protein.
Length = 264
Score = 151 bits (366), Expect = 6e-36
Identities = 80/219 (36%), Positives = 131/219 (59%), Gaps = 11/219 (5%)
Query: 23 QWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGET 81
+W+N N + DF + +G G FG V + T + YAMK LDK+++ K+KQ E
Sbjct: 36 KWENPTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEH 94
Query: 82 LALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAE 141
LNE+ +L V+ PF+V + YAF L +++ + GG++ HL + G F+E
Sbjct: 95 -TLNEKRILQ----AVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH 149
Query: 142 MKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGT 201
+FYAA+++L E++H ++YRDLKP N+L+D G+++++D G A K + GT
Sbjct: 150 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA-KRVKGRTWTLCGT 208
Query: 202 HGYMAPE-VLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
Y+APE +LSK GY+ + DW++ G ++Y++ G+ PF
Sbjct: 209 PEYLAPEIILSK--GYNKAVDWWALGVLIYEMAAGYPPF 245
>AL450063-7|CAI16850.1| 245|Homo sapiens protein kinase,
cAMP-dependent, catalytic, beta protein.
Length = 245
Score = 151 bits (366), Expect = 6e-36
Identities = 80/219 (36%), Positives = 131/219 (59%), Gaps = 11/219 (5%)
Query: 23 QWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGET 81
+W+N N + DF + +G G FG V + T + YAMK LDK+++ K+KQ E
Sbjct: 18 KWENPTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEH 76
Query: 82 LALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAE 141
LNE+ +L V+ PF+V + YAF L +++ + GG++ HL + G F+E
Sbjct: 77 -TLNEKRILQ----AVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH 131
Query: 142 MKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGT 201
+FYAA+++L E++H ++YRDLKP N+L+D G+++++D G A K + GT
Sbjct: 132 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA-KRVKGRTWTLCGT 190
Query: 202 HGYMAPE-VLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
Y+APE +LSK GY+ + DW++ G ++Y++ G+ PF
Sbjct: 191 PEYLAPEIILSK--GYNKAVDWWALGVLIYEMAAGYPPF 227
>AL450063-3|CAI16846.1| 398|Homo sapiens protein kinase,
cAMP-dependent, catalytic, beta protein.
Length = 398
Score = 151 bits (366), Expect = 6e-36
Identities = 80/219 (36%), Positives = 131/219 (59%), Gaps = 11/219 (5%)
Query: 23 QWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGET 81
+W+N N + DF + +G G FG V + T + YAMK LDK+++ K+KQ E
Sbjct: 77 KWENPTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEH 135
Query: 82 LALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAE 141
LNE+ +L V+ PF+V + YAF L +++ + GG++ HL + G F+E
Sbjct: 136 -TLNEKRILQ----AVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH 190
Query: 142 MKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGT 201
+FYAA+++L E++H ++YRDLKP N+L+D G+++++D G A K + GT
Sbjct: 191 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA-KRVKGRTWTLCGT 249
Query: 202 HGYMAPE-VLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
Y+APE +LSK GY+ + DW++ G ++Y++ G+ PF
Sbjct: 250 PEYLAPEIILSK--GYNKAVDWWALGVLIYEMAAGYPPF 286
Score = 65.3 bits (152), Expect = 5e-10
Identities = 35/97 (36%), Positives = 51/97 (52%), Gaps = 5/97 (5%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P FS LK LL LLQ D+ KR G G ++K H +FA DW +Y +K P IP
Sbjct: 306 PSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPK 365
Query: 344 -RGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDF 379
RG + D + ++EED + + +TE ++ +F
Sbjct: 366 FRG---SGDTSNFDDYEEEDIR-VSITEKCAKEFGEF 398
>AL450063-2|CAI16845.1| 351|Homo sapiens protein kinase,
cAMP-dependent, catalytic, beta protein.
Length = 351
Score = 151 bits (366), Expect = 6e-36
Identities = 80/219 (36%), Positives = 131/219 (59%), Gaps = 11/219 (5%)
Query: 23 QWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGET 81
+W+N N + DF + +G G FG V + T + YAMK LDK+++ K+KQ E
Sbjct: 30 KWENPTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEH 88
Query: 82 LALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAE 141
LNE+ +L V+ PF+V + YAF L +++ + GG++ HL + G F+E
Sbjct: 89 -TLNEKRILQ----AVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH 143
Query: 142 MKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGT 201
+FYAA+++L E++H ++YRDLKP N+L+D G+++++D G A K + GT
Sbjct: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA-KRVKGRTWTLCGT 202
Query: 202 HGYMAPE-VLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
Y+APE +LSK GY+ + DW++ G ++Y++ G+ PF
Sbjct: 203 PEYLAPEIILSK--GYNKAVDWWALGVLIYEMAAGYPPF 239
Score = 65.3 bits (152), Expect = 5e-10
Identities = 35/97 (36%), Positives = 51/97 (52%), Gaps = 5/97 (5%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P FS LK LL LLQ D+ KR G G ++K H +FA DW +Y +K P IP
Sbjct: 259 PSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPK 318
Query: 344 -RGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDF 379
RG + D + ++EED + + +TE ++ +F
Sbjct: 319 FRG---SGDTSNFDDYEEEDIR-VSITEKCAKEFGEF 351
>AL450063-1|CAI16844.1| 257|Homo sapiens protein kinase,
cAMP-dependent, catalytic, beta protein.
Length = 257
Score = 151 bits (366), Expect = 6e-36
Identities = 80/219 (36%), Positives = 131/219 (59%), Gaps = 11/219 (5%)
Query: 23 QWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGET 81
+W+N N + DF + +G G FG V + T + YAMK LDK+++ K+KQ E
Sbjct: 30 KWENPTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEH 88
Query: 82 LALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAE 141
LNE+ +L V+ PF+V + YAF L +++ + GG++ HL + G F+E
Sbjct: 89 -TLNEKRILQ----AVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH 143
Query: 142 MKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGT 201
+FYAA+++L E++H ++YRDLKP N+L+D G+++++D G A K + GT
Sbjct: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA-KRVKGRTWTLCGT 202
Query: 202 HGYMAPE-VLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
Y+APE +LSK GY+ + DW++ G ++Y++ G+ PF
Sbjct: 203 PEYLAPEIILSK--GYNKAVDWWALGVLIYEMAAGYPPF 239
>AL359504-2|CAI14541.1| 351|Homo sapiens protein kinase,
cAMP-dependent, catalytic, beta protein.
Length = 351
Score = 151 bits (366), Expect = 6e-36
Identities = 80/219 (36%), Positives = 131/219 (59%), Gaps = 11/219 (5%)
Query: 23 QWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGET 81
+W+N N + DF + +G G FG V + T + YAMK LDK+++ K+KQ E
Sbjct: 30 KWENPTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEH 88
Query: 82 LALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAE 141
LNE+ +L V+ PF+V + YAF L +++ + GG++ HL + G F+E
Sbjct: 89 -TLNEKRILQ----AVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH 143
Query: 142 MKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGT 201
+FYAA+++L E++H ++YRDLKP N+L+D G+++++D G A K + GT
Sbjct: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA-KRVKGRTWTLCGT 202
Query: 202 HGYMAPE-VLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
Y+APE +LSK GY+ + DW++ G ++Y++ G+ PF
Sbjct: 203 PEYLAPEIILSK--GYNKAVDWWALGVLIYEMAAGYPPF 239
Score = 65.3 bits (152), Expect = 5e-10
Identities = 35/97 (36%), Positives = 51/97 (52%), Gaps = 5/97 (5%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P FS LK LL LLQ D+ KR G G ++K H +FA DW +Y +K P IP
Sbjct: 259 PSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPK 318
Query: 344 -RGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDF 379
RG + D + ++EED + + +TE ++ +F
Sbjct: 319 FRG---SGDTSNFDDYEEEDIR-VSITEKCAKEFGEF 351
>AL359504-1|CAI14540.1| 257|Homo sapiens protein kinase,
cAMP-dependent, catalytic, beta protein.
Length = 257
Score = 151 bits (366), Expect = 6e-36
Identities = 80/219 (36%), Positives = 131/219 (59%), Gaps = 11/219 (5%)
Query: 23 QWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGET 81
+W+N N + DF + +G G FG V + T + YAMK LDK+++ K+KQ E
Sbjct: 30 KWENPTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEH 88
Query: 82 LALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAE 141
LNE+ +L V+ PF+V + YAF L +++ + GG++ HL + G F+E
Sbjct: 89 -TLNEKRILQ----AVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH 143
Query: 142 MKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGT 201
+FYAA+++L E++H ++YRDLKP N+L+D G+++++D G A K + GT
Sbjct: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA-KRVKGRTWTLCGT 202
Query: 202 HGYMAPE-VLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
Y+APE +LSK GY+ + DW++ G ++Y++ G+ PF
Sbjct: 203 PEYLAPEIILSK--GYNKAVDWWALGVLIYEMAAGYPPF 239
>AB209189-1|BAD92426.1| 365|Homo sapiens cAMP-dependent protein
kinase catalytic subunit beta isoform 2 variant protein.
Length = 365
Score = 151 bits (366), Expect = 6e-36
Identities = 80/219 (36%), Positives = 131/219 (59%), Gaps = 11/219 (5%)
Query: 23 QWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGET 81
+W+N N + DF + +G G FG V + T + YAMK LDK+++ K+KQ E
Sbjct: 56 KWENPTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEH 114
Query: 82 LALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAE 141
LNE+ +L V+ PF+V + YAF L +++ + GG++ HL + G F+E
Sbjct: 115 -TLNEKRILQ----AVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH 169
Query: 142 MKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGT 201
+FYAA+++L E++H ++YRDLKP N+L+D G+++++D G A K + GT
Sbjct: 170 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA-KRVKGRTWTLCGT 228
Query: 202 HGYMAPE-VLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
Y+APE +LSK GY+ + DW++ G ++Y++ G+ PF
Sbjct: 229 PEYLAPEIILSK--GYNKAVDWWALGVLIYEMAAGYPPF 265
Score = 57.2 bits (132), Expect = 1e-07
Identities = 26/59 (44%), Positives = 32/59 (54%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIP 342
P FS LK LL LLQ D+ KR G G ++K H +FA DW +Y +K P IP
Sbjct: 285 PSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIP 343
>BC035058-1|AAH35058.1| 351|Homo sapiens protein kinase,
cAMP-dependent, catalytic, beta protein.
Length = 351
Score = 149 bits (361), Expect = 3e-35
Identities = 80/219 (36%), Positives = 131/219 (59%), Gaps = 11/219 (5%)
Query: 23 QWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGET 81
+W+N N + DF + +G G FG V + T + YAMK LDK+++ K+KQ E
Sbjct: 30 KWENPTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEH 88
Query: 82 LALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAE 141
LNE+ +L V+ PF+V + YAF L +++ + GG++ HL + G F+E
Sbjct: 89 -TLNEKRILQ----AVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH 143
Query: 142 MKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGT 201
+FYAA+++L E+++ I+YRDLKP N+L+D G+++++D G A K + GT
Sbjct: 144 ARFYAAQIVLTFEYLNSLDIIYRDLKPENLLIDHQGYIQVTDFGFA-KRVKGRTWTLCGT 202
Query: 202 HGYMAPE-VLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
Y+APE +LSK GY+ + DW++ G ++Y++ G+ PF
Sbjct: 203 PEYLAPEIILSK--GYNKAVDWWALGVLIYEMAAGYPPF 239
Score = 66.1 bits (154), Expect = 3e-10
Identities = 35/97 (36%), Positives = 52/97 (53%), Gaps = 5/97 (5%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P +FS LK LL LLQ D+ KR G G ++K H +FA DW +Y +K P IP
Sbjct: 259 PSNFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPK 318
Query: 344 -RGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDF 379
RG + D + ++EED + + +TE ++ +F
Sbjct: 319 FRG---SGDTSNFDDYEEEDIR-VSITEKCAKEFGEF 351
>X07767-1|CAA30597.1| 351|Homo sapiens protein ( Human mRNA for
cAMP-dependent protein kinase catalytic subunit type
alpha (EC 2.7.1.37). ).
Length = 351
Score = 148 bits (359), Expect = 5e-35
Identities = 75/207 (36%), Positives = 128/207 (61%), Gaps = 10/207 (4%)
Query: 35 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGETLALNERIMLSLV 93
++ F + +G G FG V + +TG YAMK LDK+++ K+KQ E LNE+ +L
Sbjct: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEH-TLNEKRILQ-- 97
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
V+ PF+V + ++F L +++ + GG++ HL + G F+E +FYAA+++L
Sbjct: 98 --AVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE-VLSK 212
E++H ++YRDLKP N+L+D+ G+++++D G A K + GT Y+APE +LSK
Sbjct: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA-KRVKGRTWTLCGTPEYLAPEIILSK 214
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPF 239
GY+ + DW++ G ++Y++ G+ PF
Sbjct: 215 --GYNKAVDWWALGVLIYEMAAGYPPF 239
Score = 61.3 bits (142), Expect = 9e-09
Identities = 32/96 (33%), Positives = 48/96 (50%), Gaps = 3/96 (3%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P FS LK LL LLQ D+ KR G G +++K H +FA DW +Y +K P IP
Sbjct: 259 PSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPK 318
Query: 344 RGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDF 379
FD ++EE+ + + + E ++ +F
Sbjct: 319 FKGPGDTSNFD--DYEEEEIR-VSINEKCGKEFSEF 351
>DQ667173-1|ABG25918.1| 351|Homo sapiens protein kinase,
cAMP-dependent, catalytic, alpha protein.
Length = 351
Score = 148 bits (359), Expect = 5e-35
Identities = 75/207 (36%), Positives = 128/207 (61%), Gaps = 10/207 (4%)
Query: 35 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGETLALNERIMLSLV 93
++ F + +G G FG V + +TG YAMK LDK+++ K+KQ E LNE+ +L
Sbjct: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEH-TLNEKRILQ-- 97
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
V+ PF+V + ++F L +++ + GG++ HL + G F+E +FYAA+++L
Sbjct: 98 --AVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE-VLSK 212
E++H ++YRDLKP N+L+D+ G+++++D G A K + GT Y+APE +LSK
Sbjct: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA-KRVKGRTWTLCGTPEYLAPEIILSK 214
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPF 239
GY+ + DW++ G ++Y++ G+ PF
Sbjct: 215 --GYNKAVDWWALGVLIYEMAAGYPPF 239
Score = 61.3 bits (142), Expect = 9e-09
Identities = 32/96 (33%), Positives = 48/96 (50%), Gaps = 3/96 (3%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P FS LK LL LLQ D+ KR G G +++K H +FA DW +Y +K P IP
Sbjct: 259 PSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPK 318
Query: 344 RGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDF 379
FD ++EE+ + + + E ++ +F
Sbjct: 319 FKGPGDTSNFD--DYEEEEIR-VSINEKCGKEFSEF 351
>BC108259-1|AAI08260.1| 351|Homo sapiens protein kinase,
cAMP-dependent, catalytic, alpha protein.
Length = 351
Score = 148 bits (359), Expect = 5e-35
Identities = 75/207 (36%), Positives = 128/207 (61%), Gaps = 10/207 (4%)
Query: 35 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGETLALNERIMLSLV 93
++ F + +G G FG V + +TG YAMK LDK+++ K+KQ E LNE+ +L
Sbjct: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEH-TLNEKRILQ-- 97
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
V+ PF+V + ++F L +++ + GG++ HL + G F+E +FYAA+++L
Sbjct: 98 --AVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE-VLSK 212
E++H ++YRDLKP N+L+D+ G+++++D G A K + GT Y+APE +LSK
Sbjct: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA-KRVKGRTWTLCGTPEYLAPEIILSK 214
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPF 239
GY+ + DW++ G ++Y++ G+ PF
Sbjct: 215 --GYNKAVDWWALGVLIYEMAAGYPPF 239
Score = 61.3 bits (142), Expect = 9e-09
Identities = 32/96 (33%), Positives = 48/96 (50%), Gaps = 3/96 (3%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P FS LK LL LLQ D+ KR G G +++K H +FA DW +Y +K P IP
Sbjct: 259 PSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPK 318
Query: 344 RGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDF 379
FD ++EE+ + + + E ++ +F
Sbjct: 319 FKGPGDTSNFD--DYEEEEIR-VSINEKCGKEFSEF 351
>BC039846-1|AAH39846.1| 351|Homo sapiens protein kinase,
cAMP-dependent, catalytic, alpha protein.
Length = 351
Score = 148 bits (359), Expect = 5e-35
Identities = 75/207 (36%), Positives = 128/207 (61%), Gaps = 10/207 (4%)
Query: 35 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGETLALNERIMLSLV 93
++ F + +G G FG V + +TG YAMK LDK+++ K+KQ E LNE+ +L
Sbjct: 41 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEH-TLNEKRILQ-- 97
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
V+ PF+V + ++F L +++ + GG++ HL + G F+E +FYAA+++L
Sbjct: 98 --AVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE-VLSK 212
E++H ++YRDLKP N+L+D+ G+++++D G A K + GT Y+APE +LSK
Sbjct: 156 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA-KRVKGRTWTLCGTPEYLAPEIILSK 214
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPF 239
GY+ + DW++ G ++Y++ G+ PF
Sbjct: 215 --GYNKAVDWWALGVLIYEMAAGYPPF 239
Score = 61.3 bits (142), Expect = 9e-09
Identities = 32/96 (33%), Positives = 48/96 (50%), Gaps = 3/96 (3%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P FS LK LL LLQ D+ KR G G +++K H +FA DW +Y +K P IP
Sbjct: 259 PSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPK 318
Query: 344 RGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDF 379
FD ++EE+ + + + E ++ +F
Sbjct: 319 FKGPGDTSNFD--DYEEEEIR-VSINEKCGKEFSEF 351
>AB209475-1|BAD92712.1| 461|Homo sapiens protein kinase C, alpha
variant protein.
Length = 461
Score = 147 bits (356), Expect = 1e-34
Identities = 73/210 (34%), Positives = 121/210 (57%), Gaps = 6/210 (2%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
++ + DF+ ++G+G FG+V + T ++YA+K L K + + E+ +L+
Sbjct: 244 RVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLA 303
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
L+ PF+ + F T D+L F+++ +NGGDL YH+ Q G F E + FY AE+ +
Sbjct: 304 LLDKP---PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYVAEISI 360
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEV 209
GL +HKR I+YRDLK N++LD GH++I+D G+ + GT Y+APE+
Sbjct: 361 GLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEI 420
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
++ Y S DW+++G +LY++L G F
Sbjct: 421 IAY-QPYGKSVDWWAYGVLLYEMLAGQVMF 449
>DQ355971-1|ABC67469.1| 1711|Homo sapiens CDC42 binding protein
kinase beta (DMPK-like) protein.
Length = 1711
Score = 147 bits (355), Expect = 1e-34
Identities = 110/366 (30%), Positives = 175/366 (47%), Gaps = 44/366 (12%)
Query: 4 LLSHAHYNICYSDKYT-RFCQWKN----LELNIQLTMNDFSVHRIIGRGGFGEVYGCRKA 58
L + ++ DKY F +W L +QL DF + ++IGRG FGEV +
Sbjct: 37 LYTECSHSALRRDKYVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMK 96
Query: 59 DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFI 118
+T ++YAMK L+K + +K+ ET E ++ G DC +I + YAF + L +
Sbjct: 97 NTERIYAMKILNKWEM-LKRAETACFREE--RDVLVNG-DCQWITALHYAFQDENHLYLV 152
Query: 119 LDLMNGGDLHYHLSQ-HGVFNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHG 177
+D GGDL LS+ E +FY E++L ++ +H+ H V+RD+KP N+LLD +G
Sbjct: 153 MDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNG 212
Query: 178 HVRISDLGLAC----DFSKKKPHASVGTHGYMAPEVL---SKGTG-YDSSADWFSFGCML 229
H+R++D G +C D + +VGT Y++PE+L G G Y DW+S G +
Sbjct: 213 HIRLADFG-SCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCM 271
Query: 230 YKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSP 289
Y++L G +PF + T + N H V E
Sbjct: 272 YEMLYGETPFYAESLVE-------TYGKIMNHEERF---------QFPSHVTDVSE---- 311
Query: 290 SLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNA 349
K L++ L+ +RLG G ++ K+H FF G++W+ + + P IP +
Sbjct: 312 EAKDLIQRLI-CSRERRLG--QNGIEDFKKHAFFEGLNWENI--RNLEAPYIPDVSSPSD 366
Query: 350 ADAFDI 355
FD+
Sbjct: 367 TSNFDV 372
>BC048261-1|AAH48261.1| 492|Homo sapiens CDC42BPB protein protein.
Length = 492
Score = 147 bits (355), Expect = 1e-34
Identities = 110/366 (30%), Positives = 175/366 (47%), Gaps = 44/366 (12%)
Query: 4 LLSHAHYNICYSDKYT-RFCQWKN----LELNIQLTMNDFSVHRIIGRGGFGEVYGCRKA 58
L + ++ DKY F +W L +QL DF + ++IGRG FGEV +
Sbjct: 37 LYTECSHSALRRDKYVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMK 96
Query: 59 DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFI 118
+T ++YAMK L+K + +K+ ET E ++ G DC +I + YAF + L +
Sbjct: 97 NTERIYAMKILNKWEM-LKRAETACFREE--RDVLVNG-DCQWITALHYAFQDENHLYLV 152
Query: 119 LDLMNGGDLHYHLSQ-HGVFNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHG 177
+D GGDL LS+ E +FY E++L ++ +H+ H V+RD+KP N+LLD +G
Sbjct: 153 MDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNG 212
Query: 178 HVRISDLGLAC----DFSKKKPHASVGTHGYMAPEVL---SKGTG-YDSSADWFSFGCML 229
H+R++D G +C D + +VGT Y++PE+L G G Y DW+S G +
Sbjct: 213 HIRLADFG-SCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCM 271
Query: 230 YKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSP 289
Y++L G +PF + T + N H V E
Sbjct: 272 YEMLYGETPFYAESLVE-------TYGKIMNHEERF---------QFPSHVTDVSE---- 311
Query: 290 SLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNA 349
K L++ L+ +RLG G ++ K+H FF G++W+ + + P IP +
Sbjct: 312 EAKDLIQRLI-CSRERRLG--QNGIEDFKKHAFFEGLNWENI--RNLEAPYIPDVSSPSD 366
Query: 350 ADAFDI 355
FD+
Sbjct: 367 TSNFDV 372
>BC047871-1|AAH47871.1| 933|Homo sapiens CDC42BPB protein protein.
Length = 933
Score = 147 bits (355), Expect = 1e-34
Identities = 110/366 (30%), Positives = 175/366 (47%), Gaps = 44/366 (12%)
Query: 4 LLSHAHYNICYSDKYT-RFCQWKN----LELNIQLTMNDFSVHRIIGRGGFGEVYGCRKA 58
L + ++ DKY F +W L +QL DF + ++IGRG FGEV +
Sbjct: 37 LYTECSHSALRRDKYVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMK 96
Query: 59 DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFI 118
+T ++YAMK L+K + +K+ ET E ++ G DC +I + YAF + L +
Sbjct: 97 NTERIYAMKILNKWEM-LKRAETACFREE--RDVLVNG-DCQWITALHYAFQDENHLYLV 152
Query: 119 LDLMNGGDLHYHLSQ-HGVFNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHG 177
+D GGDL LS+ E +FY E++L ++ +H+ H V+RD+KP N+LLD +G
Sbjct: 153 MDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNG 212
Query: 178 HVRISDLGLAC----DFSKKKPHASVGTHGYMAPEVL---SKGTG-YDSSADWFSFGCML 229
H+R++D G +C D + +VGT Y++PE+L G G Y DW+S G +
Sbjct: 213 HIRLADFG-SCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCM 271
Query: 230 YKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSP 289
Y++L G +PF + T + N H V E
Sbjct: 272 YEMLYGETPFYAESLVE-------TYGKIMNHEERF---------QFPSHVTDVSE---- 311
Query: 290 SLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNA 349
K L++ L+ +RLG G ++ K+H FF G++W+ + + P IP +
Sbjct: 312 EAKDLIQRLI-CSRERRLG--QNGIEDFKKHAFFEGLNWENI--RNLEAPYIPDVSSPSD 366
Query: 350 ADAFDI 355
FD+
Sbjct: 367 TSNFDV 372
>AF128625-1|AAD37506.1| 1711|Homo sapiens CDC42-binding protein
kinase beta protein.
Length = 1711
Score = 147 bits (355), Expect = 1e-34
Identities = 110/366 (30%), Positives = 175/366 (47%), Gaps = 44/366 (12%)
Query: 4 LLSHAHYNICYSDKYT-RFCQWKN----LELNIQLTMNDFSVHRIIGRGGFGEVYGCRKA 58
L + ++ DKY F +W L +QL DF + ++IGRG FGEV +
Sbjct: 37 LYTECSHSALRRDKYVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMK 96
Query: 59 DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFI 118
+T ++YAMK L+K + +K+ ET E ++ G DC +I + YAF + L +
Sbjct: 97 NTERIYAMKILNKWEM-LKRAETACFREE--RDVLVNG-DCQWITALHYAFQDENHLYLV 152
Query: 119 LDLMNGGDLHYHLSQ-HGVFNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHG 177
+D GGDL LS+ E +FY E++L ++ +H+ H V+RD+KP N+LLD +G
Sbjct: 153 MDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNG 212
Query: 178 HVRISDLGLAC----DFSKKKPHASVGTHGYMAPEVL---SKGTG-YDSSADWFSFGCML 229
H+R++D G +C D + +VGT Y++PE+L G G Y DW+S G +
Sbjct: 213 HIRLADFG-SCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCM 271
Query: 230 YKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSP 289
Y++L G +PF + T + N H V E
Sbjct: 272 YEMLYGETPFYAESLVE-------TYGKIMNHEERF---------QFPSHVTDVSE---- 311
Query: 290 SLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNA 349
K L++ L+ +RLG G ++ K+H FF G++W+ + + P IP +
Sbjct: 312 EAKDLIQRLI-CSRERRLG--QNGIEDFKKHAFFEGLNWENI--RNLEAPYIPDVSSPSD 366
Query: 350 ADAFDI 355
FD+
Sbjct: 367 TSNFDV 372
>AB032950-1|BAA86438.2| 1760|Homo sapiens KIAA1124 protein protein.
Length = 1760
Score = 147 bits (355), Expect = 1e-34
Identities = 110/366 (30%), Positives = 175/366 (47%), Gaps = 44/366 (12%)
Query: 4 LLSHAHYNICYSDKYT-RFCQWKN----LELNIQLTMNDFSVHRIIGRGGFGEVYGCRKA 58
L + ++ DKY F +W L +QL DF + ++IGRG FGEV +
Sbjct: 86 LYTECSHSALRRDKYVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMK 145
Query: 59 DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFI 118
+T ++YAMK L+K + +K+ ET E ++ G DC +I + YAF + L +
Sbjct: 146 NTERIYAMKILNKWEM-LKRAETACFREE--RDVLVNG-DCQWITALHYAFQDENHLYLV 201
Query: 119 LDLMNGGDLHYHLSQ-HGVFNEAEMKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHG 177
+D GGDL LS+ E +FY E++L ++ +H+ H V+RD+KP N+LLD +G
Sbjct: 202 MDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNG 261
Query: 178 HVRISDLGLAC----DFSKKKPHASVGTHGYMAPEVL---SKGTG-YDSSADWFSFGCML 229
H+R++D G +C D + +VGT Y++PE+L G G Y DW+S G +
Sbjct: 262 HIRLADFG-SCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCM 320
Query: 230 YKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSP 289
Y++L G +PF + T + N H V E
Sbjct: 321 YEMLYGETPFYAESLVE-------TYGKIMNHEERF---------QFPSHVTDVSE---- 360
Query: 290 SLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNA 349
K L++ L+ +RLG G ++ K+H FF G++W+ + + P IP +
Sbjct: 361 EAKDLIQRLI-CSRERRLG--QNGIEDFKKHAFFEGLNWENI--RNLEAPYIPDVSSPSD 415
Query: 350 ADAFDI 355
FD+
Sbjct: 416 TSNFDV 421
>M34182-1|AAC41690.1| 360|Homo sapiens protein kinase A
gamma-subunit protein.
Length = 360
Score = 142 bits (345), Expect = 2e-33
Identities = 78/219 (35%), Positives = 131/219 (59%), Gaps = 11/219 (5%)
Query: 23 QWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGET 81
+W N N + + F R +G G FG V R +TG YAMK L+K+++ KMKQ E
Sbjct: 39 RWGNPAQNTA-SSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEH 97
Query: 82 LALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAE 141
+ LNE+ +L +D PF+V + ++F L +++ + GG++ L + G F+E
Sbjct: 98 I-LNEKRILQ----AIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPH 152
Query: 142 MKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGT 201
FYAA+V+L ++++H +++RDLKP N+L+D+ G+++++D G A K + GT
Sbjct: 153 ACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFA-KRVKGRTWTLCGT 211
Query: 202 HGYMAPE-VLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
Y+APE +LSK GY+ + DW++ G ++Y++ G PF
Sbjct: 212 PEYLAPEIILSK--GYNKAVDWWALGVLIYEMAVGFPPF 248
Score = 59.3 bits (137), Expect = 4e-08
Identities = 31/96 (32%), Positives = 46/96 (47%), Gaps = 3/96 (3%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P S LK LL LLQ D+ KR G G ++K H +FA W +Y +K P IP
Sbjct: 268 PSKLSSDLKDLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPK 327
Query: 344 RGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDF 379
DA + ++EE+ + I + E ++ +F
Sbjct: 328 --YTGPGDASNFDDYEEEELR-ISINEKCAKEFSEF 360
>DQ667175-1|ABG25920.1| 351|Homo sapiens protein kinase,
cAMP-dependent, catalytic, gamma protein.
Length = 351
Score = 142 bits (345), Expect = 2e-33
Identities = 78/219 (35%), Positives = 131/219 (59%), Gaps = 11/219 (5%)
Query: 23 QWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGET 81
+W N N + + F R +G G FG V R +TG YAMK L+K+++ KMKQ E
Sbjct: 30 RWGNPAQNTA-SSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEH 88
Query: 82 LALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAE 141
+ LNE+ +L +D PF+V + ++F L +++ + GG++ L + G F+E
Sbjct: 89 I-LNEKRILQ----AIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPH 143
Query: 142 MKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGT 201
FYAA+V+L ++++H +++RDLKP N+L+D+ G+++++D G A K + GT
Sbjct: 144 ACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFA-KRVKGRTWTLCGT 202
Query: 202 HGYMAPE-VLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
Y+APE +LSK GY+ + DW++ G ++Y++ G PF
Sbjct: 203 PEYLAPEIILSK--GYNKAVDWWALGVLIYEMAVGFPPF 239
Score = 58.8 bits (136), Expect = 5e-08
Identities = 31/96 (32%), Positives = 46/96 (47%), Gaps = 3/96 (3%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P S LK LL LLQ D+ KR G G ++K H +FA W +Y +K P IP
Sbjct: 259 PSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPK 318
Query: 344 RGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDF 379
DA + ++EE+ + I + E ++ +F
Sbjct: 319 --YTGPGDASNFDDYEEEELR-ISINEKCAKEFSEF 351
>BC039888-1|AAH39888.1| 351|Homo sapiens protein kinase,
cAMP-dependent, catalytic, gamma protein.
Length = 351
Score = 142 bits (345), Expect = 2e-33
Identities = 78/219 (35%), Positives = 131/219 (59%), Gaps = 11/219 (5%)
Query: 23 QWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGET 81
+W N N + + F R +G G FG V R +TG YAMK L+K+++ KMKQ E
Sbjct: 30 RWGNPAQNTA-SSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEH 88
Query: 82 LALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAE 141
+ LNE+ +L +D PF+V + ++F L +++ + GG++ L + G F+E
Sbjct: 89 I-LNEKRILQ----AIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPH 143
Query: 142 MKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGT 201
FYAA+V+L ++++H +++RDLKP N+L+D+ G+++++D G A K + GT
Sbjct: 144 ACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFA-KRVKGRTWTLCGT 202
Query: 202 HGYMAPE-VLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
Y+APE +LSK GY+ + DW++ G ++Y++ G PF
Sbjct: 203 PEYLAPEIILSK--GYNKAVDWWALGVLIYEMAVGFPPF 239
Score = 58.8 bits (136), Expect = 5e-08
Identities = 31/96 (32%), Positives = 46/96 (47%), Gaps = 3/96 (3%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P S LK LL LLQ D+ KR G G ++K H +FA W +Y +K P IP
Sbjct: 259 PSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPK 318
Query: 344 RGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDF 379
DA + ++EE+ + I + E ++ +F
Sbjct: 319 --YTGPGDASNFDDYEEEELR-ISINEKCPKEFSEF 351
>AL162730-1|CAH71828.1| 351|Homo sapiens protein kinase,
cAMP-dependent, catalytic, gamma protein.
Length = 351
Score = 142 bits (345), Expect = 2e-33
Identities = 78/219 (35%), Positives = 131/219 (59%), Gaps = 11/219 (5%)
Query: 23 QWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGET 81
+W N N + + F R +G G FG V R +TG YAMK L+K+++ KMKQ E
Sbjct: 30 RWGNPAQNTA-SSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEH 88
Query: 82 LALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAE 141
+ LNE+ +L +D PF+V + ++F L +++ + GG++ L + G F+E
Sbjct: 89 I-LNEKRILQ----AIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPH 143
Query: 142 MKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGT 201
FYAA+V+L ++++H +++RDLKP N+L+D+ G+++++D G A K + GT
Sbjct: 144 ACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFA-KRVKGRTWTLCGT 202
Query: 202 HGYMAPE-VLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
Y+APE +LSK GY+ + DW++ G ++Y++ G PF
Sbjct: 203 PEYLAPEIILSK--GYNKAVDWWALGVLIYEMAVGFPPF 239
Score = 58.8 bits (136), Expect = 5e-08
Identities = 31/96 (32%), Positives = 46/96 (47%), Gaps = 3/96 (3%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P S LK LL LLQ D+ KR G G ++K H +FA W +Y +K P IP
Sbjct: 259 PSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPK 318
Query: 344 RGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDF 379
DA + ++EE+ + I + E ++ +F
Sbjct: 319 --YTGPGDASNFDDYEEEELR-ISINEKCAKEFSEF 351
>AJ001597-1|CAA04863.1| 351|Homo sapiens cAMP-dependent protein
kinase gamma isoform protein.
Length = 351
Score = 142 bits (345), Expect = 2e-33
Identities = 78/219 (35%), Positives = 131/219 (59%), Gaps = 11/219 (5%)
Query: 23 QWKNLELNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGET 81
+W N N + + F R +G G FG V R +TG YAMK L+K+++ KMKQ E
Sbjct: 30 RWGNPAQNTA-SSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEH 88
Query: 82 LALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAE 141
+ LNE+ +L +D PF+V + ++F L +++ + GG++ L + G F+E
Sbjct: 89 I-LNEKRILQ----AIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPH 143
Query: 142 MKFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGT 201
FYAA+V+L ++++H +++RDLKP N+L+D+ G+++++D G A K + GT
Sbjct: 144 ACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFA-KRVKGRTWTLCGT 202
Query: 202 HGYMAPE-VLSKGTGYDSSADWFSFGCMLYKLLKGHSPF 239
Y+APE +LSK GY+ + DW++ G ++Y++ G PF
Sbjct: 203 PEYLAPEIILSK--GYNKAVDWWALGVLIYEMAVGFPPF 239
Score = 58.8 bits (136), Expect = 5e-08
Identities = 31/96 (32%), Positives = 46/96 (47%), Gaps = 3/96 (3%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPP 343
P S LK LL LLQ D+ KR G G ++K H +FA W +Y +K P IP
Sbjct: 259 PSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPK 318
Query: 344 RGEVNAADAFDIGSFDEEDTKGIKLTETDQMQYKDF 379
DA + ++EE+ + I + E ++ +F
Sbjct: 319 --YTGPGDASNFDDYEEEELR-ISINEKCAKEFSEF 351
>AY358353-1|AAQ88719.1| 364|Homo sapiens HSA250839 protein.
Length = 364
Score = 142 bits (343), Expect = 4e-33
Identities = 84/268 (31%), Positives = 135/268 (50%), Gaps = 31/268 (11%)
Query: 93 VSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILG 152
+ G++ PF+V + Y+F + + ++DL+ GGDL YHL Q+ F E +K Y E+ L
Sbjct: 24 IMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALA 83
Query: 153 LEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDF-SKKKPHASVGTHGYMAPEV-- 209
LE++ + HI++RD+KP NILLDEHGHV I+D +A ++ + GT YMAPEV
Sbjct: 84 LEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSMAGTKPYMAPEVFQ 143
Query: 210 --LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXX 267
+ +G GY DW+S G Y+LL+G P+ H EI L M +
Sbjct: 144 VYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEI----LNMFK------VE 193
Query: 268 XXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGID 327
+ST + + +LL LL +D R+ +++ + A ++
Sbjct: 194 RVHYSST------------WCKGMVALLRKLLTKDPESRVS----SLHDIQSVPYLADMN 237
Query: 328 WQQVYHQKYTPPLIPPRGEVNAADAFDI 355
W V+ + P +P +G +N F++
Sbjct: 238 WDAVFKKALMPGFVPNKGRLNCDPTFEL 265
>AY648038-1|AAT67172.1| 1551|Homo sapiens myotonic dystrophy
kinase-related CDC42-binding kinase gamma protein.
Length = 1551
Score = 141 bits (341), Expect = 7e-33
Identities = 107/334 (32%), Positives = 171/334 (51%), Gaps = 39/334 (11%)
Query: 31 IQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 90
++L +DF + ++IGRG FGEV R+ DTG+++AMK L K + +K+ ET E
Sbjct: 64 LRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEM-LKRAETACFREE--R 120
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEM-KFYAAEV 149
++ G D ++ + YAF + L ++D GGDL LS+ E+ +FY AE+
Sbjct: 121 DVLVKG-DSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEM 179
Query: 150 ILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKK---KPHASVGTHGYMA 206
+L + +H+ V+RD+KP N+LLD +GH+R++D G + +VGT Y++
Sbjct: 180 VLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYIS 239
Query: 207 PEVL---SKGTG-YDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXX 262
PE+L +G G Y DW+S G Y+LL G +PF + T + N
Sbjct: 240 PEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVE-------TYGKIMNHE 292
Query: 263 XXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVF 322
+ VP+ S + L+ LL R +RLG +G G D+ + H F
Sbjct: 293 DHL------------QFPPDVPD-VPASAQDLIRQLLCRQ-EERLG-RG-GLDDFRNHPF 336
Query: 323 FAGIDWQQVYHQKYTPPLIPP-RGEVNAADAFDI 355
F G+DW+++ T P IP RG ++ ++ FD+
Sbjct: 337 FEGVDWERL--ASSTAPYIPELRGPMDTSN-FDV 367
>D87931-1|BAA75636.1| 1388|Homo sapiens Rho kinase protein.
Length = 1388
Score = 140 bits (338), Expect = 2e-32
Identities = 78/215 (36%), Positives = 121/215 (56%), Gaps = 11/215 (5%)
Query: 31 IQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 90
+Q+ D+ V ++IGRG FGEV R + K+YAMK L K + + ER ++
Sbjct: 85 LQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIM 144
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVI 150
+ ++ P++V + YAF L +++ M GGDL +S + V E KFY AEV+
Sbjct: 145 AFANS----PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEKWAKFYTAEVV 199
Query: 151 LGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKK-KPH--ASVGTHGYMAP 207
L L+ +H +++RD+KP N+LLD+HGH++++D G + H +VGT Y++P
Sbjct: 200 LALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISP 259
Query: 208 EVLSKGTG---YDSSADWFSFGCMLYKLLKGHSPF 239
EVL G Y DW+S G LY++L G +PF
Sbjct: 260 EVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPF 294
>AC018463-2|AAX93049.1| 1337|Homo sapiens unknown protein.
Length = 1337
Score = 140 bits (338), Expect = 2e-32
Identities = 78/215 (36%), Positives = 121/215 (56%), Gaps = 11/215 (5%)
Query: 31 IQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 90
+Q+ D+ V ++IGRG FGEV R + K+YAMK L K + + ER ++
Sbjct: 38 LQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIM 97
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVI 150
+ ++ P++V + YAF L +++ M GGDL +S + V E KFY AEV+
Sbjct: 98 AFANS----PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEKWAKFYTAEVV 152
Query: 151 LGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKK-KPH--ASVGTHGYMAP 207
L L+ +H +++RD+KP N+LLD+HGH++++D G + H +VGT Y++P
Sbjct: 153 LALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISP 212
Query: 208 EVLSKGTG---YDSSADWFSFGCMLYKLLKGHSPF 239
EVL G Y DW+S G LY++L G +PF
Sbjct: 213 EVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPF 247
>AB014519-1|BAA31594.2| 1428|Homo sapiens KIAA0619 protein protein.
Length = 1428
Score = 140 bits (338), Expect = 2e-32
Identities = 78/215 (36%), Positives = 121/215 (56%), Gaps = 11/215 (5%)
Query: 31 IQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 90
+Q+ D+ V ++IGRG FGEV R + K+YAMK L K + + ER ++
Sbjct: 125 LQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIM 184
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVI 150
+ ++ P++V + YAF L +++ M GGDL +S + V E KFY AEV+
Sbjct: 185 AFANS----PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEKWAKFYTAEVV 239
Query: 151 LGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKK-KPH--ASVGTHGYMAP 207
L L+ +H +++RD+KP N+LLD+HGH++++D G + H +VGT Y++P
Sbjct: 240 LALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISP 299
Query: 208 EVLSKGTG---YDSSADWFSFGCMLYKLLKGHSPF 239
EVL G Y DW+S G LY++L G +PF
Sbjct: 300 EVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPF 334
>U43195-1|AAB02814.1| 1354|Homo sapiens Rho-associated, coiled-coil
containing protein kinase p160ROCK protein.
Length = 1354
Score = 139 bits (337), Expect = 2e-32
Identities = 103/343 (30%), Positives = 165/343 (48%), Gaps = 41/343 (11%)
Query: 30 NIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 89
++++ D+ V ++IGRG FGEV R T K+YAMK L K + + ER +
Sbjct: 68 DLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDI 127
Query: 90 LSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEV 149
++ ++ P++V + YAF L +++ M GGDL +S + V E +FY AEV
Sbjct: 128 MAFANS----PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEKWARFYTAEV 182
Query: 150 ILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKK---KPHASVGTHGYMA 206
+L L+ +H ++RD+KP N+LLD+ GH++++D G +K+ + +VGT Y++
Sbjct: 183 VLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYIS 242
Query: 207 PEVLSKGTG---YDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXX 263
PEVL G Y DW+S G LY++L G +PF T + + N
Sbjct: 243 PEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVG-------TYSKIMNHKN 295
Query: 264 XXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFF 323
S T + S K+L+ L D RLG G +E+K H+FF
Sbjct: 296 ---------SLTFPD-----DNDISKEAKNLICAFL-TDREVRLG--RNGVEEIKRHLFF 338
Query: 324 AGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDE-EDTKG 365
W + P++P + + D +FD+ E+ KG
Sbjct: 339 KNDQWAWETLRDTVAPVVP-----DLSSDIDTSNFDDLEEDKG 376
>Z92868-1|CAB07437.1| 686|Homo sapiens cGMP-dependent protein
kinase type I beta protein.
Length = 686
Score = 138 bits (334), Expect = 5e-32
Identities = 95/333 (28%), Positives = 162/333 (48%), Gaps = 34/333 (10%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCR-KADTGKMYAMKCLDKKRI-KMKQGETLALNERIML 90
L ++DF++ +G GGFG V + K++ K +AMK L K+ I +Q E + ++IM
Sbjct: 370 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM- 428
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVI 150
G FIV + F L +++ GG+L L G F ++ +FY A V+
Sbjct: 429 ----QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVV 484
Query: 151 LGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEV 209
++H + I+YRDLKP N++LD G+ ++ D G A KK GT Y+APE+
Sbjct: 485 EAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEI 544
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
+ G+D SAD++S G ++Y+LL G PF + I + M+
Sbjct: 545 I-LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIE---------- 593
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
P+ + + +L++ L + + ++RLG G ++++H +F G +W+
Sbjct: 594 -------------FPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWE 640
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEED 362
+ TPP+IP + D + SF E++
Sbjct: 641 GLRKGTLTPPIIP--SVASPTDTSNFDSFPEDN 671
>Z92867-1|CAB07436.1| 671|Homo sapiens cGMP-dependent protein
kinase type I alpha protein.
Length = 671
Score = 138 bits (334), Expect = 5e-32
Identities = 95/333 (28%), Positives = 162/333 (48%), Gaps = 34/333 (10%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCR-KADTGKMYAMKCLDKKRI-KMKQGETLALNERIML 90
L ++DF++ +G GGFG V + K++ K +AMK L K+ I +Q E + ++IM
Sbjct: 355 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM- 413
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVI 150
G FIV + F L +++ GG+L L G F ++ +FY A V+
Sbjct: 414 ----QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVV 469
Query: 151 LGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEV 209
++H + I+YRDLKP N++LD G+ ++ D G A KK GT Y+APE+
Sbjct: 470 EAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEI 529
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
+ G+D SAD++S G ++Y+LL G PF + I + M+
Sbjct: 530 I-LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIE---------- 578
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
P+ + + +L++ L + + ++RLG G ++++H +F G +W+
Sbjct: 579 -------------FPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWE 625
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEED 362
+ TPP+IP + D + SF E++
Sbjct: 626 GLRKGTLTPPIIP--SVASPTDTSNFDSFPEDN 656
>Y07512-1|CAA68810.1| 686|Homo sapiens protein ( Human mRNA for
type I beta cGMP-dependent protein kinase (EC
2.7.1.37). ).
Length = 686
Score = 138 bits (334), Expect = 5e-32
Identities = 95/333 (28%), Positives = 162/333 (48%), Gaps = 34/333 (10%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCR-KADTGKMYAMKCLDKKRI-KMKQGETLALNERIML 90
L ++DF++ +G GGFG V + K++ K +AMK L K+ I +Q E + ++IM
Sbjct: 370 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM- 428
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVI 150
G FIV + F L +++ GG+L L G F ++ +FY A V+
Sbjct: 429 ----QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVV 484
Query: 151 LGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEV 209
++H + I+YRDLKP N++LD G+ ++ D G A KK GT Y+APE+
Sbjct: 485 EAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEI 544
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
+ G+D SAD++S G ++Y+LL G PF + I + M+
Sbjct: 545 I-LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIE---------- 593
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
P+ + + +L++ L + + ++RLG G ++++H +F G +W+
Sbjct: 594 -------------FPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWE 640
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEED 362
+ TPP+IP + D + SF E++
Sbjct: 641 GLRKGTLTPPIIP--SVASPTDTSNFDSFPEDN 671
>D45864-1|BAA08297.1| 671|Homo sapiens cGMP-dependent protein
kinase type I alpha protein.
Length = 671
Score = 138 bits (334), Expect = 5e-32
Identities = 95/333 (28%), Positives = 162/333 (48%), Gaps = 34/333 (10%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCR-KADTGKMYAMKCLDKKRI-KMKQGETLALNERIML 90
L ++DF++ +G GGFG V + K++ K +AMK L K+ I +Q E + ++IM
Sbjct: 355 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM- 413
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVI 150
G FIV + F L +++ GG+L L G F ++ +FY A V+
Sbjct: 414 ----QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVV 469
Query: 151 LGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEV 209
++H + I+YRDLKP N++LD G+ ++ D G A KK GT Y+APE+
Sbjct: 470 EAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEI 529
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
+ G+D SAD++S G ++Y+LL G PF + I + M+
Sbjct: 530 I-LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIE---------- 578
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
P+ + + +L++ L + + ++RLG G ++++H +F G +W+
Sbjct: 579 -------------FPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWE 625
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEED 362
+ TPP+IP + D + SF E++
Sbjct: 626 GLRKGTLTPPIIP--SVASPTDTSNFDSFPEDN 656
>BC127090-1|AAI27091.1| 686|Homo sapiens protein kinase,
cGMP-dependent, type I protein.
Length = 686
Score = 138 bits (334), Expect = 5e-32
Identities = 95/333 (28%), Positives = 162/333 (48%), Gaps = 34/333 (10%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCR-KADTGKMYAMKCLDKKRI-KMKQGETLALNERIML 90
L ++DF++ +G GGFG V + K++ K +AMK L K+ I +Q E + ++IM
Sbjct: 370 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM- 428
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVI 150
G FIV + F L +++ GG+L L G F ++ +FY A V+
Sbjct: 429 ----QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVV 484
Query: 151 LGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEV 209
++H + I+YRDLKP N++LD G+ ++ D G A KK GT Y+APE+
Sbjct: 485 EAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEI 544
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
+ G+D SAD++S G ++Y+LL G PF + I + M+
Sbjct: 545 I-LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIE---------- 593
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
P+ + + +L++ L + + ++RLG G ++++H +F G +W+
Sbjct: 594 -------------FPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWE 640
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEED 362
+ TPP+IP + D + SF E++
Sbjct: 641 GLRKGTLTPPIIP--SVASPTDTSNFDSFPEDN 671
>AL928686-2|CAI40743.1| 686|Homo sapiens protein kinase,
cGMP-dependent, type I protein.
Length = 686
Score = 138 bits (334), Expect = 5e-32
Identities = 95/333 (28%), Positives = 162/333 (48%), Gaps = 34/333 (10%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCR-KADTGKMYAMKCLDKKRI-KMKQGETLALNERIML 90
L ++DF++ +G GGFG V + K++ K +AMK L K+ I +Q E + ++IM
Sbjct: 370 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM- 428
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVI 150
G FIV + F L +++ GG+L L G F ++ +FY A V+
Sbjct: 429 ----QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVV 484
Query: 151 LGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEV 209
++H + I+YRDLKP N++LD G+ ++ D G A KK GT Y+APE+
Sbjct: 485 EAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEI 544
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
+ G+D SAD++S G ++Y+LL G PF + I + M+
Sbjct: 545 I-LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIE---------- 593
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
P+ + + +L++ L + + ++RLG G ++++H +F G +W+
Sbjct: 594 -------------FPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWE 640
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEED 362
+ TPP+IP + D + SF E++
Sbjct: 641 GLRKGTLTPPIIP--SVASPTDTSNFDSFPEDN 671
>AL928686-1|CAI40742.1| 659|Homo sapiens protein kinase,
cGMP-dependent, type I protein.
Length = 659
Score = 138 bits (334), Expect = 5e-32
Identities = 95/333 (28%), Positives = 162/333 (48%), Gaps = 34/333 (10%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCR-KADTGKMYAMKCLDKKRI-KMKQGETLALNERIML 90
L ++DF++ +G GGFG V + K++ K +AMK L K+ I +Q E + ++IM
Sbjct: 343 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM- 401
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVI 150
G FIV + F L +++ GG+L L G F ++ +FY A V+
Sbjct: 402 ----QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVV 457
Query: 151 LGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEV 209
++H + I+YRDLKP N++LD G+ ++ D G A KK GT Y+APE+
Sbjct: 458 EAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEI 517
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
+ G+D SAD++S G ++Y+LL G PF + I + M+
Sbjct: 518 I-LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIE---------- 566
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
P+ + + +L++ L + + ++RLG G ++++H +F G +W+
Sbjct: 567 -------------FPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWE 613
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEED 362
+ TPP+IP + D + SF E++
Sbjct: 614 GLRKGTLTPPIIP--SVASPTDTSNFDSFPEDN 644
>AL731537-3|CAI17115.1| 686|Homo sapiens protein kinase,
cGMP-dependent, type I protein.
Length = 686
Score = 138 bits (334), Expect = 5e-32
Identities = 95/333 (28%), Positives = 162/333 (48%), Gaps = 34/333 (10%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCR-KADTGKMYAMKCLDKKRI-KMKQGETLALNERIML 90
L ++DF++ +G GGFG V + K++ K +AMK L K+ I +Q E + ++IM
Sbjct: 370 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM- 428
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVI 150
G FIV + F L +++ GG+L L G F ++ +FY A V+
Sbjct: 429 ----QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVV 484
Query: 151 LGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEV 209
++H + I+YRDLKP N++LD G+ ++ D G A KK GT Y+APE+
Sbjct: 485 EAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEI 544
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
+ G+D SAD++S G ++Y+LL G PF + I + M+
Sbjct: 545 I-LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIE---------- 593
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
P+ + + +L++ L + + ++RLG G ++++H +F G +W+
Sbjct: 594 -------------FPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWE 640
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEED 362
+ TPP+IP + D + SF E++
Sbjct: 641 GLRKGTLTPPIIP--SVASPTDTSNFDSFPEDN 671
>AL731537-2|CAI17114.1| 659|Homo sapiens protein kinase,
cGMP-dependent, type I protein.
Length = 659
Score = 138 bits (334), Expect = 5e-32
Identities = 95/333 (28%), Positives = 162/333 (48%), Gaps = 34/333 (10%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCR-KADTGKMYAMKCLDKKRI-KMKQGETLALNERIML 90
L ++DF++ +G GGFG V + K++ K +AMK L K+ I +Q E + ++IM
Sbjct: 343 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM- 401
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVI 150
G FIV + F L +++ GG+L L G F ++ +FY A V+
Sbjct: 402 ----QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVV 457
Query: 151 LGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEV 209
++H + I+YRDLKP N++LD G+ ++ D G A KK GT Y+APE+
Sbjct: 458 EAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEI 517
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
+ G+D SAD++S G ++Y+LL G PF + I + M+
Sbjct: 518 I-LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIE---------- 566
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
P+ + + +L++ L + + ++RLG G ++++H +F G +W+
Sbjct: 567 -------------FPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWE 613
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEED 362
+ TPP+IP + D + SF E++
Sbjct: 614 GLRKGTLTPPIIP--SVASPTDTSNFDSFPEDN 644
>AL391378-2|CAI39626.1| 686|Homo sapiens protein kinase,
cGMP-dependent, type I protein.
Length = 686
Score = 138 bits (334), Expect = 5e-32
Identities = 95/333 (28%), Positives = 162/333 (48%), Gaps = 34/333 (10%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCR-KADTGKMYAMKCLDKKRI-KMKQGETLALNERIML 90
L ++DF++ +G GGFG V + K++ K +AMK L K+ I +Q E + ++IM
Sbjct: 370 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM- 428
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVI 150
G FIV + F L +++ GG+L L G F ++ +FY A V+
Sbjct: 429 ----QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVV 484
Query: 151 LGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEV 209
++H + I+YRDLKP N++LD G+ ++ D G A KK GT Y+APE+
Sbjct: 485 EAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEI 544
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
+ G+D SAD++S G ++Y+LL G PF + I + M+
Sbjct: 545 I-LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIE---------- 593
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
P+ + + +L++ L + + ++RLG G ++++H +F G +W+
Sbjct: 594 -------------FPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWE 640
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEED 362
+ TPP+IP + D + SF E++
Sbjct: 641 GLRKGTLTPPIIP--SVASPTDTSNFDSFPEDN 671
>AL391378-1|CAI39625.1| 659|Homo sapiens protein kinase,
cGMP-dependent, type I protein.
Length = 659
Score = 138 bits (334), Expect = 5e-32
Identities = 95/333 (28%), Positives = 162/333 (48%), Gaps = 34/333 (10%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCR-KADTGKMYAMKCLDKKRI-KMKQGETLALNERIML 90
L ++DF++ +G GGFG V + K++ K +AMK L K+ I +Q E + ++IM
Sbjct: 343 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM- 401
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVI 150
G FIV + F L +++ GG+L L G F ++ +FY A V+
Sbjct: 402 ----QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVV 457
Query: 151 LGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEV 209
++H + I+YRDLKP N++LD G+ ++ D G A KK GT Y+APE+
Sbjct: 458 EAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEI 517
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
+ G+D SAD++S G ++Y+LL G PF + I + M+
Sbjct: 518 I-LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIE---------- 566
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
P+ + + +L++ L + + ++RLG G ++++H +F G +W+
Sbjct: 567 -------------FPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWE 613
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEED 362
+ TPP+IP + D + SF E++
Sbjct: 614 GLRKGTLTPPIIP--SVASPTDTSNFDSFPEDN 644
>AL157399-2|CAI41305.1| 686|Homo sapiens protein kinase,
cGMP-dependent, type I protein.
Length = 686
Score = 138 bits (334), Expect = 5e-32
Identities = 95/333 (28%), Positives = 162/333 (48%), Gaps = 34/333 (10%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCR-KADTGKMYAMKCLDKKRI-KMKQGETLALNERIML 90
L ++DF++ +G GGFG V + K++ K +AMK L K+ I +Q E + ++IM
Sbjct: 370 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM- 428
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVI 150
G FIV + F L +++ GG+L L G F ++ +FY A V+
Sbjct: 429 ----QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVV 484
Query: 151 LGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEV 209
++H + I+YRDLKP N++LD G+ ++ D G A KK GT Y+APE+
Sbjct: 485 EAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEI 544
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
+ G+D SAD++S G ++Y+LL G PF + I + M+
Sbjct: 545 I-LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIE---------- 593
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
P+ + + +L++ L + + ++RLG G ++++H +F G +W+
Sbjct: 594 -------------FPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWE 640
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEED 362
+ TPP+IP + D + SF E++
Sbjct: 641 GLRKGTLTPPIIP--SVASPTDTSNFDSFPEDN 671
>AL157399-1|CAI41304.1| 659|Homo sapiens protein kinase,
cGMP-dependent, type I protein.
Length = 659
Score = 138 bits (334), Expect = 5e-32
Identities = 95/333 (28%), Positives = 162/333 (48%), Gaps = 34/333 (10%)
Query: 33 LTMNDFSVHRIIGRGGFGEVYGCR-KADTGKMYAMKCLDKKRI-KMKQGETLALNERIML 90
L ++DF++ +G GGFG V + K++ K +AMK L K+ I +Q E + ++IM
Sbjct: 343 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM- 401
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVI 150
G FIV + F L +++ GG+L L G F ++ +FY A V+
Sbjct: 402 ----QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVV 457
Query: 151 LGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEV 209
++H + I+YRDLKP N++LD G+ ++ D G A KK GT Y+APE+
Sbjct: 458 EAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEI 517
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXXXXXXXX 269
+ G+D SAD++S G ++Y+LL G PF + I + M+
Sbjct: 518 I-LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIE---------- 566
Query: 270 XXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQ 329
P+ + + +L++ L + + ++RLG G ++++H +F G +W+
Sbjct: 567 -------------FPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWE 613
Query: 330 QVYHQKYTPPLIPPRGEVNAADAFDIGSFDEED 362
+ TPP+IP + D + SF E++
Sbjct: 614 GLRKGTLTPPIIP--SVASPTDTSNFDSFPEDN 644
>BC062558-1|AAH62558.1| 889|Homo sapiens protein kinase N3 protein.
Length = 889
Score = 138 bits (333), Expect = 6e-32
Identities = 76/208 (36%), Positives = 120/208 (57%), Gaps = 7/208 (3%)
Query: 35 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQG-ETLALNERIMLSLV 93
+ DF ++GRG FG+V + TGK YA+K L K+ + + E+L +RI+ ++
Sbjct: 556 LQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVG 615
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
TG PF++ + F T CF+ + + GGDL + + VF E + +FY A V+LGL
Sbjct: 616 CTGH--PFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHED-VFPEPQARFYVACVVLGL 672
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLS 211
+ +H++ I+YRDLK N+LLD G ++I+D GL + S GT ++APEVL+
Sbjct: 673 QFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLT 732
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPF 239
+ Y + DW+ G +LY++L G PF
Sbjct: 733 Q-EAYTRAVDWWGLGVLLYEMLVGECPF 759
Score = 38.7 bits (86), Expect = 0.054
Identities = 17/48 (35%), Positives = 27/48 (56%)
Query: 295 LEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIP 342
++ LLQ+ KRLG + A+E+K FF +WQ + + PP +P
Sbjct: 790 IQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVP 837
>AL441992-1|CAI15401.1| 889|Homo sapiens protein kinase N3 protein.
Length = 889
Score = 138 bits (333), Expect = 6e-32
Identities = 76/208 (36%), Positives = 120/208 (57%), Gaps = 7/208 (3%)
Query: 35 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQG-ETLALNERIMLSLV 93
+ DF ++GRG FG+V + TGK YA+K L K+ + + E+L +RI+ ++
Sbjct: 556 LQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVG 615
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
TG PF++ + F T CF+ + + GGDL + + VF E + +FY A V+LGL
Sbjct: 616 CTGH--PFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHED-VFPEPQARFYVACVVLGL 672
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLS 211
+ +H++ I+YRDLK N+LLD G ++I+D GL + S GT ++APEVL+
Sbjct: 673 QFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLT 732
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPF 239
+ Y + DW+ G +LY++L G PF
Sbjct: 733 Q-EAYTRAVDWWGLGVLLYEMLVGECPF 759
Score = 38.7 bits (86), Expect = 0.054
Identities = 17/48 (35%), Positives = 27/48 (56%)
Query: 295 LEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIP 342
++ LLQ+ KRLG + A+E+K FF +WQ + + PP +P
Sbjct: 790 IQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVP 837
>AY702977-1|AAU29340.1| 643|Homo sapiens protein kinase C theta
protein.
Length = 643
Score = 137 bits (331), Expect = 1e-31
Identities = 70/183 (38%), Positives = 109/183 (59%), Gaps = 5/183 (2%)
Query: 29 LNIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERI 88
L I+L + DF +H+++G+G FG+V+ T + +A+K L K + M + E+
Sbjct: 371 LQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKR 430
Query: 89 MLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAE 148
+LSL + PF+ M F T + L F+++ +NGGDL YH+ F+ + FYAAE
Sbjct: 431 VLSLAW---EHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAE 487
Query: 149 VILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMA 206
+ILGL+ +H + IVYRDLK NILLD+ GH++I+D G+ + K + GT Y+A
Sbjct: 488 IILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIA 547
Query: 207 PEV 209
PE+
Sbjct: 548 PEL 550
Score = 36.3 bits (80), Expect = 0.29
Identities = 19/64 (29%), Positives = 33/64 (51%), Gaps = 9/64 (14%)
Query: 298 LLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGS 357
L R+ KRLG +G ++++H F I+W+++ ++ PP P FD +
Sbjct: 550 LFVREPEKRLGVRG----DIRQHPLFREINWEELERKEIDPPFRP-----KVKSPFDCSN 600
Query: 358 FDEE 361
FD+E
Sbjct: 601 FDKE 604
>BC113114-1|AAI13115.1| 1354|Homo sapiens Rho-associated,
coiled-coil containing protein kinase 1 protein.
Length = 1354
Score = 134 bits (325), Expect = 6e-31
Identities = 101/343 (29%), Positives = 163/343 (47%), Gaps = 41/343 (11%)
Query: 30 NIQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 89
++++ D+ V ++IGRG FGEV R T K+YAMK L K + + ER +
Sbjct: 68 DLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDI 127
Query: 90 LSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEV 149
++ ++ P++V + YAF L +++ M GGDL +S + E +FY AEV
Sbjct: 128 MAFANS----PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDA-PEKWARFYTAEV 182
Query: 150 ILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKK---KPHASVGTHGYMA 206
+L L+ +H ++ D+KP N+LLD+ GH++++D G +K+ + +VGT Y++
Sbjct: 183 VLALDAIHSMGFIHGDVKPDNMLLDKSGHLKLADFGTRMKMNKEGMVRCDTAVGTPDYIS 242
Query: 207 PEVLSKGTG---YDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXXX 263
PEVL G Y DW+S G LY++L G +PF T + + N
Sbjct: 243 PEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVG-------TYSKIMNHKN 295
Query: 264 XXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVFF 323
S T + S K+L+ L D RLG G +E+K H+FF
Sbjct: 296 ---------SLTFPD-----DNDISKEAKNLICAFL-TDREVRLG--RNGVEEIKRHLFF 338
Query: 324 AGIDWQQVYHQKYTPPLIPPRGEVNAADAFDIGSFDE-EDTKG 365
W + P++P + + D +FD+ E+ KG
Sbjct: 339 KNDQWAWETLRDTVAPVVP-----DLSSDIDTSNFDDLEEDKG 376
>X65293-1|CAA46388.1| 737|Homo sapiens protein kinase C epsilon
protein.
Length = 737
Score = 134 bits (324), Expect = 8e-31
Identities = 69/220 (31%), Positives = 119/220 (54%), Gaps = 6/220 (2%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
+L +++F+ +++G+G FG+V ++YA+K L K I + E+ +L+
Sbjct: 402 RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILA 461
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
L P++ + F T D+L F+++ +NGGDL + + + F+E +FYAAEV
Sbjct: 462 LARKH---PYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTS 518
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEV 209
L +H+ ++YRDLK NILLD GH +++D G+ + + GT Y+APE+
Sbjct: 519 ALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEI 578
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHE 249
L + Y S DW++ G ++Y+++ G PF D E
Sbjct: 579 LQE-LEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFE 617
Score = 47.2 bits (107), Expect = 2e-04
Identities = 27/83 (32%), Positives = 43/83 (51%), Gaps = 7/83 (8%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKG--RGADEVKEHVFFAGIDWQQVYHQKYTPPLI 341
P S S+L+ + ++ +KRLGC G D +K+H FF IDW + +K PP
Sbjct: 627 PVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPP-F 685
Query: 342 PPRGEVNAADAFDIGSFDEEDTK 364
PR + D+ +FD++ T+
Sbjct: 686 KPRIKTKR----DVNNFDQDFTR 704
>BC109034-1|AAI09035.1| 737|Homo sapiens protein kinase C, epsilon
protein.
Length = 737
Score = 134 bits (324), Expect = 8e-31
Identities = 69/220 (31%), Positives = 119/220 (54%), Gaps = 6/220 (2%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
+L +++F+ +++G+G FG+V ++YA+K L K I + E+ +L+
Sbjct: 402 RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILA 461
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
L P++ + F T D+L F+++ +NGGDL + + + F+E +FYAAEV
Sbjct: 462 LARKH---PYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTS 518
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEV 209
L +H+ ++YRDLK NILLD GH +++D G+ + + GT Y+APE+
Sbjct: 519 ALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEI 578
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHE 249
L + Y S DW++ G ++Y+++ G PF D E
Sbjct: 579 LQE-LEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFE 617
Score = 47.2 bits (107), Expect = 2e-04
Identities = 27/83 (32%), Positives = 43/83 (51%), Gaps = 7/83 (8%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKG--RGADEVKEHVFFAGIDWQQVYHQKYTPPLI 341
P S S+L+ + ++ +KRLGC G D +K+H FF IDW + +K PP
Sbjct: 627 PVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPP-F 685
Query: 342 PPRGEVNAADAFDIGSFDEEDTK 364
PR + D+ +FD++ T+
Sbjct: 686 KPRIKTKR----DVNNFDQDFTR 704
>BC109033-1|AAI09034.1| 737|Homo sapiens protein kinase C, epsilon
protein.
Length = 737
Score = 134 bits (324), Expect = 8e-31
Identities = 69/220 (31%), Positives = 119/220 (54%), Gaps = 6/220 (2%)
Query: 32 QLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 91
+L +++F+ +++G+G FG+V ++YA+K L K I + E+ +L+
Sbjct: 402 RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILA 461
Query: 92 LVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVIL 151
L P++ + F T D+L F+++ +NGGDL + + + F+E +FYAAEV
Sbjct: 462 LARKH---PYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTS 518
Query: 152 GLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEV 209
L +H+ ++YRDLK NILLD GH +++D G+ + + GT Y+APE+
Sbjct: 519 ALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEI 578
Query: 210 LSKGTGYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHE 249
L + Y S DW++ G ++Y+++ G PF D E
Sbjct: 579 LQE-LEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFE 617
Score = 47.2 bits (107), Expect = 2e-04
Identities = 27/83 (32%), Positives = 43/83 (51%), Gaps = 7/83 (8%)
Query: 284 PESFSPSLKSLLEGLLQRDINKRLGCKG--RGADEVKEHVFFAGIDWQQVYHQKYTPPLI 341
P S S+L+ + ++ +KRLGC G D +K+H FF IDW + +K PP
Sbjct: 627 PVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPP-F 685
Query: 342 PPRGEVNAADAFDIGSFDEEDTK 364
PR + D+ +FD++ T+
Sbjct: 686 KPRIKTKR----DVNNFDQDFTR 704
>AB019692-1|BAA85625.1| 889|Homo sapiens protein kinase PKNbeta
protein.
Length = 889
Score = 134 bits (324), Expect = 8e-31
Identities = 75/208 (36%), Positives = 120/208 (57%), Gaps = 7/208 (3%)
Query: 35 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQG-ETLALNERIMLSLV 93
+ DF ++GRG FG+V + TGK YA+K L K+ + + E+L +RI+ ++
Sbjct: 556 LQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVG 615
Query: 94 STGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGL 153
TG PF++ + F T F+ + + GGDL + + VF E + +FY A V+LGL
Sbjct: 616 CTGH--PFLLSLLVCFQTSSHARFVTEFVPGGDLMMQIHED-VFPEPQARFYVACVVLGL 672
Query: 154 EHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLS 211
+ +H++ I+YRDLK N+LLD G ++I+D GL + S GT ++APEVL+
Sbjct: 673 QFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLT 732
Query: 212 KGTGYDSSADWFSFGCMLYKLLKGHSPF 239
+ Y + DW++ G +LY++L G PF
Sbjct: 733 Q-EAYTQAVDWWALGVLLYEMLVGECPF 759
Score = 38.7 bits (86), Expect = 0.054
Identities = 17/48 (35%), Positives = 27/48 (56%)
Query: 295 LEGLLQRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIP 342
++ LLQ+ KRLG + A+E+K FF +WQ + + PP +P
Sbjct: 790 IQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVP 837
>Y15056-1|CAA75341.1| 556|Homo sapiens PkB kinase protein.
Length = 556
Score = 133 bits (321), Expect = 2e-30
Identities = 73/208 (35%), Positives = 122/208 (58%), Gaps = 9/208 (4%)
Query: 37 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 96
DF +I+G G F V R+ T + YA+K L+K+ I + ER ++S +
Sbjct: 81 DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL--- 137
Query: 97 VDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHM 156
D PF V + + F +KL F L G+L ++ + G F+E +FY AE++ LE++
Sbjct: 138 -DHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYL 196
Query: 157 HKRHIVYRDLKPANILLDEHGHVRISDLG----LACDFSKKKPHASVGTHGYMAPEVLSK 212
H + I++RDLKP NILL+E H++I+D G L+ + + + ++ VGT Y++PE+L++
Sbjct: 197 HGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTE 256
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPFR 240
+ SS D ++ GC++Y+L+ G PFR
Sbjct: 257 KSACKSS-DLWALGCIIYQLVAGLPPFR 283
Score = 49.2 bits (112), Expect = 4e-05
Identities = 25/61 (40%), Positives = 33/61 (54%), Gaps = 3/61 (4%)
Query: 280 ERGVPESFSPSLKSLLEGLLQRDINKRLGCKG-RGADEVKEHVFFAGIDWQQVYHQKYTP 338
E PE F P + L+E LL D KRLGC+ G +K H FF + W+ ++ Q TP
Sbjct: 298 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ--TP 355
Query: 339 P 339
P
Sbjct: 356 P 356
>CR536517-1|CAG38755.1| 556|Homo sapiens PDPK1 protein.
Length = 556
Score = 133 bits (321), Expect = 2e-30
Identities = 73/208 (35%), Positives = 122/208 (58%), Gaps = 9/208 (4%)
Query: 37 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 96
DF +I+G G F V R+ T + YA+K L+K+ I + ER ++S +
Sbjct: 81 DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL--- 137
Query: 97 VDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHM 156
D PF V + + F +KL F L G+L ++ + G F+E +FY AE++ LE++
Sbjct: 138 -DHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYL 196
Query: 157 HKRHIVYRDLKPANILLDEHGHVRISDLG----LACDFSKKKPHASVGTHGYMAPEVLSK 212
H + I++RDLKP NILL+E H++I+D G L+ + + + ++ VGT Y++PE+L++
Sbjct: 197 HGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTE 256
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPFR 240
+ SS D ++ GC++Y+L+ G PFR
Sbjct: 257 KSACKSS-DLWALGCIIYQLVAGLPPFR 283
Score = 49.2 bits (112), Expect = 4e-05
Identities = 25/61 (40%), Positives = 33/61 (54%), Gaps = 3/61 (4%)
Query: 280 ERGVPESFSPSLKSLLEGLLQRDINKRLGCKG-RGADEVKEHVFFAGIDWQQVYHQKYTP 338
E PE F P + L+E LL D KRLGC+ G +K H FF + W+ ++ Q TP
Sbjct: 298 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ--TP 355
Query: 339 P 339
P
Sbjct: 356 P 356
>BC012103-1|AAH12103.1| 556|Homo sapiens 3-phosphoinositide
dependent protein kinase-1 protein.
Length = 556
Score = 133 bits (321), Expect = 2e-30
Identities = 73/208 (35%), Positives = 122/208 (58%), Gaps = 9/208 (4%)
Query: 37 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 96
DF +I+G G F V R+ T + YA+K L+K+ I + ER ++S +
Sbjct: 81 DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL--- 137
Query: 97 VDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHM 156
D PF V + + F +KL F L G+L ++ + G F+E +FY AE++ LE++
Sbjct: 138 -DHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYL 196
Query: 157 HKRHIVYRDLKPANILLDEHGHVRISDLG----LACDFSKKKPHASVGTHGYMAPEVLSK 212
H + I++RDLKP NILL+E H++I+D G L+ + + + ++ VGT Y++PE+L++
Sbjct: 197 HGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTE 256
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPFR 240
+ SS D ++ GC++Y+L+ G PFR
Sbjct: 257 KSACKSS-DLWALGCIIYQLVAGLPPFR 283
Score = 49.2 bits (112), Expect = 4e-05
Identities = 25/61 (40%), Positives = 33/61 (54%), Gaps = 3/61 (4%)
Query: 280 ERGVPESFSPSLKSLLEGLLQRDINKRLGCKG-RGADEVKEHVFFAGIDWQQVYHQKYTP 338
E PE F P + L+E LL D KRLGC+ G +K H FF + W+ ++ Q TP
Sbjct: 298 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ--TP 355
Query: 339 P 339
P
Sbjct: 356 P 356
>AY166586-1|AAN86031.1| 1638|Homo sapiens CDC42-binding protein
kinase beta protein.
Length = 1638
Score = 133 bits (321), Expect = 2e-30
Identities = 100/333 (30%), Positives = 160/333 (48%), Gaps = 37/333 (11%)
Query: 31 IQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 90
++L DF + ++IGRG FGEV + + K++AMK L+K + +K+ ET E
Sbjct: 70 MRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEM-LKRAETACFREE--R 126
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQ-HGVFNEAEMKFYAAEV 149
++ G D +I + YAF + L ++D GGDL LS+ E +FY AE+
Sbjct: 127 DVLVNG-DNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEM 185
Query: 150 ILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKK---KPHASVGTHGYMA 206
++ ++ +H+ H V+RD+KP NIL+D +GH+R++D G + + +VGT Y++
Sbjct: 186 VIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYIS 245
Query: 207 PEVL---SKGTG-YDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDKMTLTMLRNXX 262
PE+L G G Y DW+S G +Y++L G +PF + T + N
Sbjct: 246 PEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVE-------TYGKIMN-- 296
Query: 263 XXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLLQRDINKRLGCKGRGADEVKEHVF 322
A T V E+ ++ L+ G RLG G ++ K+H F
Sbjct: 297 -HKERFQFPAQVT------DVSENAKDPIRRLICGR-----EHRLGQSG--IEDFKKHPF 342
Query: 323 FAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDI 355
F+GIDW + + P IP FD+
Sbjct: 343 FSGIDWDNI--RNCEAPYIPEVSSPTDTSNFDV 373
>AF017995-1|AAC51825.1| 556|Homo sapiens 3-phosphoinositide
dependent protein kinase-1 protein.
Length = 556
Score = 133 bits (321), Expect = 2e-30
Identities = 73/208 (35%), Positives = 122/208 (58%), Gaps = 9/208 (4%)
Query: 37 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 96
DF +I+G G F V R+ T + YA+K L+K+ I + ER ++S +
Sbjct: 81 DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL--- 137
Query: 97 VDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHM 156
D PF V + + F +KL F L G+L ++ + G F+E +FY AE++ LE++
Sbjct: 138 -DHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYL 196
Query: 157 HKRHIVYRDLKPANILLDEHGHVRISDLG----LACDFSKKKPHASVGTHGYMAPEVLSK 212
H + I++RDLKP NILL+E H++I+D G L+ + + + ++ VGT Y++PE+L++
Sbjct: 197 HGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTE 256
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPFR 240
+ SS D ++ GC++Y+L+ G PFR
Sbjct: 257 KSACKSS-DLWALGCIIYQLVAGLPPFR 283
Score = 49.2 bits (112), Expect = 4e-05
Identities = 25/61 (40%), Positives = 33/61 (54%), Gaps = 3/61 (4%)
Query: 280 ERGVPESFSPSLKSLLEGLLQRDINKRLGCKG-RGADEVKEHVFFAGIDWQQVYHQKYTP 338
E PE F P + L+E LL D KRLGC+ G +K H FF + W+ ++ Q TP
Sbjct: 298 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ--TP 355
Query: 339 P 339
P
Sbjct: 356 P 356
>AC005591-1|AAC33797.1| 367|Homo sapiens PkB-like protein.
Length = 367
Score = 133 bits (321), Expect = 2e-30
Identities = 73/208 (35%), Positives = 122/208 (58%), Gaps = 9/208 (4%)
Query: 37 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 96
DF +I+G G F V R+ T + YA+K L+K+ I + ER ++S +
Sbjct: 73 DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL--- 129
Query: 97 VDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHM 156
D PF V + + F +KL F L G+L ++ + G F+E +FY AE++ LE++
Sbjct: 130 -DHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYL 188
Query: 157 HKRHIVYRDLKPANILLDEHGHVRISDLG----LACDFSKKKPHASVGTHGYMAPEVLSK 212
H + I++RDLKP NILL+E H++I+D G L+ + + + ++ VGT Y++PE+L++
Sbjct: 189 HGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTE 248
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPFR 240
+ SS D ++ GC++Y+L+ G PFR
Sbjct: 249 KSACKSS-DLWALGCIIYQLVAGLPPFR 275
Score = 49.2 bits (112), Expect = 4e-05
Identities = 25/61 (40%), Positives = 33/61 (54%), Gaps = 3/61 (4%)
Query: 280 ERGVPESFSPSLKSLLEGLLQRDINKRLGCKG-RGADEVKEHVFFAGIDWQQVYHQKYTP 338
E PE F P + L+E LL D KRLGC+ G +K H FF + W+ ++ Q TP
Sbjct: 290 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ--TP 347
Query: 339 P 339
P
Sbjct: 348 P 348
>AB209835-1|BAD93072.1| 492|Homo sapiens 3-phosphoinositide
dependent protein kinase-1 variant protein.
Length = 492
Score = 133 bits (321), Expect = 2e-30
Identities = 73/208 (35%), Positives = 122/208 (58%), Gaps = 9/208 (4%)
Query: 37 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 96
DF +I+G G F V R+ T + YA+K L+K+ I + ER ++S +
Sbjct: 119 DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL--- 175
Query: 97 VDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHM 156
D PF V + + F +KL F L G+L ++ + G F+E +FY AE++ LE++
Sbjct: 176 -DHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYL 234
Query: 157 HKRHIVYRDLKPANILLDEHGHVRISDLG----LACDFSKKKPHASVGTHGYMAPEVLSK 212
H + I++RDLKP NILL+E H++I+D G L+ + + + ++ VGT Y++PE+L++
Sbjct: 235 HGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTE 294
Query: 213 GTGYDSSADWFSFGCMLYKLLKGHSPFR 240
+ SS D ++ GC++Y+L+ G PFR
Sbjct: 295 KSACKSS-DLWALGCIIYQLVAGLPPFR 321
Score = 49.2 bits (112), Expect = 4e-05
Identities = 25/61 (40%), Positives = 33/61 (54%), Gaps = 3/61 (4%)
Query: 280 ERGVPESFSPSLKSLLEGLLQRDINKRLGCKG-RGADEVKEHVFFAGIDWQQVYHQKYTP 338
E PE F P + L+E LL D KRLGC+ G +K H FF + W+ ++ Q TP
Sbjct: 336 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ--TP 393
Query: 339 P 339
P
Sbjct: 394 P 394
>S72883-1|AAB31800.1| 625|Homo sapiens myotonin protein kinase
protein.
Length = 625
Score = 132 bits (320), Expect = 2e-30
Identities = 107/343 (31%), Positives = 167/343 (48%), Gaps = 46/343 (13%)
Query: 16 DKYTR-FCQWKN---LELN-IQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLD 70
DKY F QW + L ++L +DF + ++IGRG F EV + TG++YAMK ++
Sbjct: 44 DKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMN 103
Query: 71 KKRIKMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYH 130
K + +K+GE E ++ G D +I + +AF + L +++ GGDL
Sbjct: 104 KWDM-LKRGEVSCFREE--RDVLVNG-DRRWITQLHFAFQDENYLYLVMEYYVGGDLLTL 159
Query: 131 LSQHGVFNEAEM-KFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLG---- 185
LS+ G AEM +FY AE+++ ++ +H+ V+RD+KP NILLD GH+R++D G
Sbjct: 160 LSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLK 219
Query: 186 LACDFSKKKPHASVGTHGYMAPEVL-----SKGTG-YDSSADWFSFGCMLYKLLKGHSPF 239
L D + +VGT Y++PE+L GTG Y DW++ G Y++ G +PF
Sbjct: 220 LRAD-GTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPF 278
Query: 240 RQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLL 299
T + + +L + GVPE ++ LL
Sbjct: 279 YADSTAETY----------------GKIVHYKEHLSLPLVDEGVPEEARDFIQRLL---- 318
Query: 300 QRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIP 342
RLG +G GA + + H FF G+DW + + PP P
Sbjct: 319 -CPPETRLG-RG-GAGDFRTHPFFFGLDWDGL--RDSVPPFTP 356
>L19268-1|AAA36206.1| 624|Homo sapiens protein kinase protein.
Length = 624
Score = 132 bits (320), Expect = 2e-30
Identities = 107/343 (31%), Positives = 167/343 (48%), Gaps = 46/343 (13%)
Query: 16 DKYTR-FCQWKN---LELN-IQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLD 70
DKY F QW + L ++L +DF + ++IGRG F EV + TG++YAMK ++
Sbjct: 44 DKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMN 103
Query: 71 KKRIKMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYH 130
K + +K+GE E ++ G D +I + +AF + L +++ GGDL
Sbjct: 104 KWDM-LKRGEVSCFREE--RDVLVNG-DRRWITQLHFAFQDENYLYLVMEYYVGGDLLTL 159
Query: 131 LSQHGVFNEAEM-KFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLG---- 185
LS+ G AEM +FY AE+++ ++ +H+ V+RD+KP NILLD GH+R++D G
Sbjct: 160 LSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLK 219
Query: 186 LACDFSKKKPHASVGTHGYMAPEVL-----SKGTG-YDSSADWFSFGCMLYKLLKGHSPF 239
L D + +VGT Y++PE+L GTG Y DW++ G Y++ G +PF
Sbjct: 220 LRAD-GTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPF 278
Query: 240 RQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLL 299
T + + +L + GVPE ++ LL
Sbjct: 279 YADSTAETY----------------GKIVHYKEHLSLPLVDEGVPEEARDFIQRLL---- 318
Query: 300 QRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIP 342
RLG +G GA + + H FF G+DW + + PP P
Sbjct: 319 -CPPETRLG-RG-GAGDFRTHPFFFGLDWDGL--RDSVPPFTP 356
>L08835-5|AAC14450.1| 530|Homo sapiens myotonic dystrophy kinase
protein.
Length = 530
Score = 132 bits (320), Expect = 2e-30
Identities = 107/343 (31%), Positives = 167/343 (48%), Gaps = 46/343 (13%)
Query: 16 DKYTR-FCQWKN---LELN-IQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLD 70
DKY F QW + L ++L +DF + ++IGRG F EV + TG++YAMK ++
Sbjct: 44 DKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMN 103
Query: 71 KKRIKMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYH 130
K + +K+GE E ++ G D +I + +AF + L +++ GGDL
Sbjct: 104 KWDM-LKRGEVSCFREE--RDVLVNG-DRRWITQLHFAFQDENYLYLVMEYYVGGDLLTL 159
Query: 131 LSQHGVFNEAEM-KFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLG---- 185
LS+ G AEM +FY AE+++ ++ +H+ V+RD+KP NILLD GH+R++D G
Sbjct: 160 LSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLK 219
Query: 186 LACDFSKKKPHASVGTHGYMAPEVL-----SKGTG-YDSSADWFSFGCMLYKLLKGHSPF 239
L D + +VGT Y++PE+L GTG Y DW++ G Y++ G +PF
Sbjct: 220 LRAD-GTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPF 278
Query: 240 RQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLL 299
T + + +L + GVPE ++ LL
Sbjct: 279 YADSTAETY----------------GKIVHYKEHLSLPLVDEGVPEEARDFIQRLL---- 318
Query: 300 QRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIP 342
RLG +G GA + + H FF G+DW + + PP P
Sbjct: 319 -CPPETRLG-RG-GAGDFRTHPFFFGLDWDGL--RDSVPPFTP 356
>L08835-4|AAC14451.1| 535|Homo sapiens myotonic dystrophy kinase
protein.
Length = 535
Score = 132 bits (320), Expect = 2e-30
Identities = 107/343 (31%), Positives = 167/343 (48%), Gaps = 46/343 (13%)
Query: 16 DKYTR-FCQWKN---LELN-IQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLD 70
DKY F QW + L ++L +DF + ++IGRG F EV + TG++YAMK ++
Sbjct: 44 DKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMN 103
Query: 71 KKRIKMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYH 130
K + +K+GE E ++ G D +I + +AF + L +++ GGDL
Sbjct: 104 KWDM-LKRGEVSCFREE--RDVLVNG-DRRWITQLHFAFQDENYLYLVMEYYVGGDLLTL 159
Query: 131 LSQHGVFNEAEM-KFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLG---- 185
LS+ G AEM +FY AE+++ ++ +H+ V+RD+KP NILLD GH+R++D G
Sbjct: 160 LSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLK 219
Query: 186 LACDFSKKKPHASVGTHGYMAPEVL-----SKGTG-YDSSADWFSFGCMLYKLLKGHSPF 239
L D + +VGT Y++PE+L GTG Y DW++ G Y++ G +PF
Sbjct: 220 LRAD-GTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPF 278
Query: 240 RQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLL 299
T + + +L + GVPE ++ LL
Sbjct: 279 YADSTAETY----------------GKIVHYKEHLSLPLVDEGVPEEARDFIQRLL---- 318
Query: 300 QRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIP 342
RLG +G GA + + H FF G+DW + + PP P
Sbjct: 319 -CPPETRLG-RG-GAGDFRTHPFFFGLDWDGL--RDSVPPFTP 356
>L08835-3|AAC14448.1| 624|Homo sapiens myotonic dystrophy kinase
protein.
Length = 624
Score = 132 bits (320), Expect = 2e-30
Identities = 107/343 (31%), Positives = 167/343 (48%), Gaps = 46/343 (13%)
Query: 16 DKYTR-FCQWKN---LELN-IQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLD 70
DKY F QW + L ++L +DF + ++IGRG F EV + TG++YAMK ++
Sbjct: 44 DKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMN 103
Query: 71 KKRIKMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYH 130
K + +K+GE E ++ G D +I + +AF + L +++ GGDL
Sbjct: 104 KWDM-LKRGEVSCFREE--RDVLVNG-DRRWITQLHFAFQDENYLYLVMEYYVGGDLLTL 159
Query: 131 LSQHGVFNEAEM-KFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLG---- 185
LS+ G AEM +FY AE+++ ++ +H+ V+RD+KP NILLD GH+R++D G
Sbjct: 160 LSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLK 219
Query: 186 LACDFSKKKPHASVGTHGYMAPEVL-----SKGTG-YDSSADWFSFGCMLYKLLKGHSPF 239
L D + +VGT Y++PE+L GTG Y DW++ G Y++ G +PF
Sbjct: 220 LRAD-GTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPF 278
Query: 240 RQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLL 299
T + + +L + GVPE ++ LL
Sbjct: 279 YADSTAETY----------------GKIVHYKEHLSLPLVDEGVPEEARDFIQRLL---- 318
Query: 300 QRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIP 342
RLG +G GA + + H FF G+DW + + PP P
Sbjct: 319 -CPPETRLG-RG-GAGDFRTHPFFFGLDWDGL--RDSVPPFTP 356
>L08835-2|AAC14449.1| 629|Homo sapiens myotonic dystrophy kinase
protein.
Length = 629
Score = 132 bits (320), Expect = 2e-30
Identities = 107/343 (31%), Positives = 167/343 (48%), Gaps = 46/343 (13%)
Query: 16 DKYTR-FCQWKN---LELN-IQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLD 70
DKY F QW + L ++L +DF + ++IGRG F EV + TG++YAMK ++
Sbjct: 44 DKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMN 103
Query: 71 KKRIKMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYH 130
K + +K+GE E ++ G D +I + +AF + L +++ GGDL
Sbjct: 104 KWDM-LKRGEVSCFREE--RDVLVNG-DRRWITQLHFAFQDENYLYLVMEYYVGGDLLTL 159
Query: 131 LSQHGVFNEAEM-KFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLG---- 185
LS+ G AEM +FY AE+++ ++ +H+ V+RD+KP NILLD GH+R++D G
Sbjct: 160 LSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLK 219
Query: 186 LACDFSKKKPHASVGTHGYMAPEVL-----SKGTG-YDSSADWFSFGCMLYKLLKGHSPF 239
L D + +VGT Y++PE+L GTG Y DW++ G Y++ G +PF
Sbjct: 220 LRAD-GTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPF 278
Query: 240 RQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLL 299
T + + +L + GVPE ++ LL
Sbjct: 279 YADSTAETY----------------GKIVHYKEHLSLPLVDEGVPEEARDFIQRLL---- 318
Query: 300 QRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIP 342
RLG +G GA + + H FF G+DW + + PP P
Sbjct: 319 -CPPETRLG-RG-GAGDFRTHPFFFGLDWDGL--RDSVPPFTP 356
>BC062553-1|AAH62553.1| 629|Homo sapiens DMPK protein protein.
Length = 629
Score = 132 bits (320), Expect = 2e-30
Identities = 107/343 (31%), Positives = 167/343 (48%), Gaps = 46/343 (13%)
Query: 16 DKYTR-FCQWKN---LELN-IQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLD 70
DKY F QW + L ++L +DF + ++IGRG F EV + TG++YAMK ++
Sbjct: 44 DKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMN 103
Query: 71 KKRIKMKQGETLALNERIMLSLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYH 130
K + +K+GE E ++ G D +I + +AF + L +++ GGDL
Sbjct: 104 KWDM-LKRGEVSCFREE--RDVLVNG-DRRWITQLHFAFQDENYLYLVMEYYVGGDLLTL 159
Query: 131 LSQHGVFNEAEM-KFYAAEVILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLG---- 185
LS+ G AEM +FY AE+++ ++ +H+ V+RD+KP NILLD GH+R++D G
Sbjct: 160 LSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLK 219
Query: 186 LACDFSKKKPHASVGTHGYMAPEVL-----SKGTG-YDSSADWFSFGCMLYKLLKGHSPF 239
L D + +VGT Y++PE+L GTG Y DW++ G Y++ G +PF
Sbjct: 220 LRAD-GTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPF 278
Query: 240 RQHKTKDKHEIDKMTLTMLRNXXXXXXXXXXXASTTLGEHERGVPESFSPSLKSLLEGLL 299
T + + +L + GVPE ++ LL
Sbjct: 279 YADSTAETY----------------GKIVHYKEHLSLPLVDEGVPEEARDFIQRLL---- 318
Query: 300 QRDINKRLGCKGRGADEVKEHVFFAGIDWQQVYHQKYTPPLIP 342
RLG +G GA + + H FF G+DW + + PP P
Sbjct: 319 -CPPETRLG-RG-GAGDFRTHPFFFGLDWDGL--RDSVPPFTP 356
>Z98752-6|CAI42313.1| 198|Homo sapiens serum/glucocorticoid
regulated kinase 2 protein.
Length = 198
Score = 132 bits (319), Expect = 3e-30
Identities = 66/150 (44%), Positives = 97/150 (64%), Gaps = 4/150 (2%)
Query: 37 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 96
DF ++IG+G +G+V ++ G YA+K L KK I +K+ E+ + ER S++
Sbjct: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSI-LKKKESHIMAER---SVLLKN 89
Query: 97 VDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFNEAEMKFYAAEVILGLEHM 156
V PF+V + Y+F TP+KL F+LD +NGG+L +HL + F E +FYAAEV + ++
Sbjct: 90 VRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYL 149
Query: 157 HKRHIVYRDLKPANILLDEHGHVRISDLGL 186
H +I+YRDLKP NILLD GHV ++D GL
Sbjct: 150 HSLNIIYRDLKPENILLDCQGHVVLTDFGL 179
>U59305-1|AAB37126.1| 496|Homo sapiens ser-thr protein kinase PK428
protein.
Length = 496
Score = 130 bits (315), Expect = 1e-29
Identities = 75/217 (34%), Positives = 122/217 (56%), Gaps = 12/217 (5%)
Query: 31 IQLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 90
++L DF + ++IGRG FGEV + + K++AMK L+K + +K+ ET E
Sbjct: 70 MRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEM-LKRAETACFREE--R 126
Query: 91 SLVSTGVDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQ-HGVFNEAEMKFYAAEV 149
++ G D +I + YAF + L ++D GGDL LS+ E +FY AE+
Sbjct: 127 DVLVNG-DNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEM 185
Query: 150 ILGLEHMHKRHIVYRDLKPANILLDEHGHVRISDLGLACDFSKK---KPHASVGTHGYMA 206
++ ++ +H+ H V+RD+KP NIL+D +GH+R++D G + + +VGT Y++
Sbjct: 186 VIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYIS 245
Query: 207 PEVL---SKGTG-YDSSADWFSFGCMLYKLLKGHSPF 239
PE+L G G Y DW+S G +Y++L G +PF
Sbjct: 246 PEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPF 282
Score = 31.9 bits (69), Expect = 6.2
Identities = 14/43 (32%), Positives = 21/43 (48%), Gaps = 2/43 (4%)
Query: 313 GADEVKEHVFFAGIDWQQVYHQKYTPPLIPPRGEVNAADAFDI 355
G ++ K+H FF+GIDW + + P IP FD+
Sbjct: 333 GIEDFKKHPFFSGIDWDNI--RNCEAPYIPEVSSPTDTSNFDV 373
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.319 0.135 0.408
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 80,220,745
Number of Sequences: 224733
Number of extensions: 3295911
Number of successful extensions: 17295
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 2332
Number of HSP's successfully gapped in prelim test: 383
Number of HSP's that attempted gapping in prelim test: 10501
Number of HSP's gapped (non-prelim): 3762
length of query: 568
length of database: 73,234,838
effective HSP length: 94
effective length of query: 474
effective length of database: 52,109,936
effective search space: 24700109664
effective search space used: 24700109664
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 68 (31.5 bits)
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