Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA005195-TA|BGIBMGA005195-PA|IPR002110|Ankyrin,
IPR002153|Transient receptor potential protein,
IPR002018|Carboxylesterase, type B, IPR013122|Polycystin cation
channel, PKD1/PKD2
(2086 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U13616-1|AAA64834.1| 4377|Homo sapiens ankyrin G protein. 318 1e-85
AL592430-3|CAI40518.1| 4372|Homo sapiens ankyrin 3, node of Ranv... 313 4e-84
AL359377-2|CAI41373.1| 4372|Homo sapiens ankyrin 3, node of Ranv... 313 4e-84
AL359267-1|CAH73232.1| 4372|Homo sapiens ankyrin 3, node of Ranv... 313 4e-84
Z26634-1|CAB42644.1| 3925|Homo sapiens ankyrin B (440 kDa) protein. 313 5e-84
X56958-1|CAA40279.2| 1872|Homo sapiens ankyrin (brank-2) protein. 313 5e-84
BX537758-1|CAD97827.1| 1863|Homo sapiens hypothetical protein pr... 313 5e-84
X16609-2|CAA34611.1| 1719|Homo sapiens alt. ankyrin (variant 2.2... 308 1e-82
X16609-1|CAA34610.1| 1881|Homo sapiens protein ( Human mRNA for ... 308 1e-82
U50133-1|AAB47805.1| 1856|Homo sapiens ankyrin protein. 308 1e-82
M28880-1|AAA51732.1| 1880|Homo sapiens ankyrin protein. 308 1e-82
AB209418-1|BAD92655.1| 1899|Homo sapiens ankyrin 1 isoform 4 var... 308 1e-82
AB002377-1|BAA20833.2| 1059|Homo sapiens KIAA0379 protein protein. 244 4e-63
U43965-1|AAB08437.1| 1088|Homo sapiens ankyrin G119 protein. 219 7e-56
AK097086-1|BAC04946.1| 919|Homo sapiens protein ( Homo sapiens ... 218 2e-55
BC114476-1|AAI14477.1| 785|Homo sapiens ANKRD28 protein protein. 217 3e-55
BC113868-1|AAI13869.1| 782|Homo sapiens ANKRD28 protein protein. 217 3e-55
BC106948-1|AAI06949.2| 785|Homo sapiens ANKRD28 protein protein. 217 3e-55
AL592430-2|CAI40517.1| 1071|Homo sapiens ankyrin 3, node of Ranv... 213 8e-54
AL359377-1|CAI41372.1| 1071|Homo sapiens ankyrin 3, node of Ranv... 213 8e-54
BX640674-1|CAE45806.1| 1280|Homo sapiens hypothetical protein pr... 211 2e-53
AB033049-1|BAA86537.2| 1089|Homo sapiens KIAA1223 protein protein. 211 2e-53
AK127496-1|BAC87007.1| 1375|Homo sapiens protein ( Homo sapiens ... 208 2e-52
AK126888-1|BAC86737.1| 687|Homo sapiens protein ( Homo sapiens ... 196 5e-49
AB209308-1|BAD92545.1| 931|Homo sapiens ankyrin 3 isoform 1 var... 184 3e-45
BC016985-1|AAH16985.2| 579|Homo sapiens ANKRD44 protein protein. 184 4e-45
AC013264-1|AAX93155.1| 525|Homo sapiens unknown protein. 182 1e-44
AJ541797-1|CAD62569.2| 765|Homo sapiens ankyrin repeat and kina... 177 3e-43
AF525298-1|AAM91924.1| 765|Homo sapiens X-kinase protein. 177 3e-43
AF487542-1|AAQ09005.1| 765|Homo sapiens protein kinase PKK2 pro... 177 3e-43
BC024725-1|AAH24725.1| 743|Homo sapiens ANKRD50 protein protein. 176 6e-43
AY367056-1|AAQ72374.1| 520|Homo sapiens KIAA0379-like protein p... 175 1e-42
BC063622-1|AAH63622.1| 367|Homo sapiens ANKRD44 protein protein. 171 2e-41
AL359707-2|CAC78760.1| 1166|Homo sapiens tankyrase, TRF1-interac... 170 5e-41
AF438201-1|AAL40795.1| 1166|Homo sapiens tankyrase II protein. 170 5e-41
AF342982-1|AAK25811.1| 1166|Homo sapiens tankyrase 2 protein. 170 5e-41
AF329696-1|AAK13463.1| 1166|Homo sapiens tankyrase 2 protein. 170 5e-41
AF309033-1|AAK82330.1| 1166|Homo sapiens tankyrase-2 protein. 170 5e-41
AF264912-1|AAG44694.1| 1166|Homo sapiens tankyrase-like protein ... 170 5e-41
AF305081-1|AAG25674.1| 1265|Homo sapiens tankyrase-related prote... 167 4e-40
BC112351-1|AAI12352.1| 725|Homo sapiens INVS protein protein. 165 1e-39
BC111761-1|AAI11762.1| 1065|Homo sapiens inversin, isoform a pro... 165 1e-39
BC041665-1|AAH41665.1| 604|Homo sapiens Similar to inversin pro... 165 1e-39
AL445214-4|CAI39744.1| 1065|Homo sapiens inversin protein. 165 1e-39
AL445214-3|CAI39745.2| 895|Homo sapiens inversin protein. 165 1e-39
AL356798-2|CAI40807.1| 1065|Homo sapiens inversin protein. 165 1e-39
AL356798-1|CAI40808.2| 895|Homo sapiens inversin protein. 165 1e-39
AL137072-3|CAH72173.1| 1065|Homo sapiens inversin protein. 165 1e-39
AL137072-2|CAM16212.1| 895|Homo sapiens inversin protein. 165 1e-39
AF084382-2|AAC79457.1| 895|Homo sapiens inversin protein altern... 165 1e-39
AF084382-1|AAC79456.1| 1065|Homo sapiens inversin protein protein. 165 1e-39
AF084367-1|AAC79436.1| 1065|Homo sapiens inversin protein protein. 165 1e-39
AF308285-1|AAG48253.1| 1188|Homo sapiens serologically defined b... 165 2e-39
AB014597-1|BAA31672.2| 2486|Homo sapiens KIAA0697 protein protein. 163 6e-39
BC007747-1|AAH07747.2| 830|Homo sapiens ANKRD17 protein protein. 162 1e-38
BC004173-1|AAH04173.1| 1500|Homo sapiens ANKRD17 protein protein. 162 1e-38
BC043394-1|AAH43394.1| 751|Homo sapiens ANKRD17 protein protein. 161 2e-38
BC098394-1|AAH98394.1| 1327|Homo sapiens tankyrase, TRF1-interac... 161 2e-38
AF082556-1|AAC79841.1| 1327|Homo sapiens TRF1-interacting ankyri... 161 2e-38
AF082557-1|AAC79842.1| 1094|Homo sapiens TRF1-interacting ankyri... 159 1e-37
AK000295-1|BAA91063.1| 686|Homo sapiens protein ( Homo sapiens ... 159 1e-37
AF521883-1|AAO14944.1| 2617|Homo sapiens multiple ankyrin repeat... 159 1e-37
AF521882-1|AAO14943.1| 2542|Homo sapiens multiple ankyrin repeat... 159 1e-37
AC017035-2|AAY15060.1| 394|Homo sapiens unknown protein. 159 1e-37
AF039217-1|AAD02131.2| 1013|Homo sapiens inv candidate homolog p... 157 5e-37
AK091555-1|BAC03695.1| 505|Homo sapiens protein ( Homo sapiens ... 154 3e-36
BC110618-1|AAI10619.1| 784|Homo sapiens receptor-interacting se... 152 1e-35
BC110617-1|AAI10618.1| 784|Homo sapiens receptor-interacting se... 152 1e-35
AP001743-1|BAA95526.1| 832|Homo sapiens ANKRD3 protein. 152 1e-35
AJ278016-1|CAC04247.1| 784|Homo sapiens protein kinase protein. 152 1e-35
AB047783-1|BAB56136.1| 784|Homo sapiens probable dual-specifici... 152 1e-35
AK027424-1|BAB55102.1| 784|Homo sapiens protein ( Homo sapiens ... 151 3e-35
AB209339-1|BAD92576.1| 1055|Homo sapiens tankyrase, TRF1-interac... 150 6e-35
BC050586-1|AAH50586.2| 306|Homo sapiens ANKRD44 protein protein. 148 2e-34
AK074173-1|BAB84999.1| 1486|Homo sapiens FLJ00246 protein protein. 146 7e-34
AK025859-1|BAB15260.1| 460|Homo sapiens protein ( Homo sapiens ... 146 1e-33
AY070436-1|AAL65263.1| 968|Homo sapiens hypothetical protein pr... 144 4e-33
AF217646-1|AAG41779.1| 532|Homo sapiens hypothetical protein pr... 144 4e-33
DQ436495-1|ABD96827.1| 1430|Homo sapiens death-associated protei... 139 9e-32
BC113660-1|AAI13661.1| 1430|Homo sapiens death-associated protei... 139 9e-32
AL591852-1|CAH71696.1| 1455|Homo sapiens death-associated protei... 139 9e-32
AL161787-1|CAH73544.1| 1455|Homo sapiens death-associated protei... 139 9e-32
AL160279-1|CAI16306.1| 1455|Homo sapiens death-associated protei... 139 9e-32
AB208871-1|BAD92108.1| 1433|Homo sapiens Hypothetical protein DK... 139 9e-32
X76104-1|CAA53712.1| 1431|Homo sapiens DAP-kinase protein. 138 1e-31
Y10601-1|CAA71610.1| 1119|Homo sapiens ankyrin-like protein prot... 138 3e-31
BC127127-1|AAI27128.1| 627|Homo sapiens ankyrin repeat and KH d... 134 3e-30
BC117677-1|AAI17678.1| 627|Homo sapiens ankyrin repeat and KH d... 134 3e-30
BC009420-1|AAH09420.1| 616|Homo sapiens ankyrin repeat and KH d... 134 3e-30
BC004457-1|AAH04457.2| 627|Homo sapiens ankyrin repeat and KH d... 134 3e-30
AK022041-1|BAB13958.1| 435|Homo sapiens protein ( Homo sapiens ... 134 3e-30
AF258557-1|AAG23760.1| 627|Homo sapiens PP2500 protein. 134 3e-30
BC009909-1|AAH09909.1| 627|Homo sapiens ankyrin repeat and KH d... 134 4e-30
BC050529-1|AAH50529.1| 1050|Homo sapiens ankyrin repeat domain 2... 133 7e-30
AK054561-1|BAB70755.1| 1060|Homo sapiens FLJ00040 protein protein. 133 7e-30
AL133620-1|CAB63746.1| 1031|Homo sapiens hypothetical protein pr... 119 1e-25
AL158217-11|CAI22163.1| 854|Homo sapiens espin protein. 119 1e-25
AL031848-3|CAI19773.1| 854|Homo sapiens espin protein. 119 1e-25
BC117678-1|AAI17679.1| 581|Homo sapiens ANKHD1 protein protein. 117 4e-25
AL159174-1|CAI39609.1| 692|Homo sapiens ankyrin repeat domain 6... 114 4e-24
AL096678-2|CAI42280.1| 692|Homo sapiens ankyrin repeat domain 6... 114 4e-24
AB023174-1|BAA76801.2| 693|Homo sapiens KIAA0957 protein protein. 113 5e-24
BC042173-1|AAH42173.1| 722|Homo sapiens ankyrin repeat domain 6... 113 8e-24
BC101275-1|AAI01276.1| 423|Homo sapiens ANKDD1A protein protein. 111 2e-23
AF451977-1|AAL49758.1| 1431|Homo sapiens cask-interacting protei... 110 6e-23
BC062346-1|AAH62346.1| 361|Homo sapiens ankyrin repeat domain 1... 109 8e-23
AL137186-4|CAI41072.1| 361|Homo sapiens ankyrin repeat domain 1... 109 8e-23
AB046856-1|BAB13462.2| 1864|Homo sapiens KIAA1636 protein protein. 109 1e-22
BC110582-1|AAI10583.1| 1006|Homo sapiens mindbomb homolog 1 (Dro... 109 1e-22
BC110581-1|AAI10582.1| 1006|Homo sapiens mindbomb homolog 1 (Dro... 109 1e-22
AY149908-1|AAN75493.1| 1006|Homo sapiens mind bomb protein. 109 1e-22
AY147849-1|AAN18023.1| 997|Homo sapiens MINDBOMB protein. 109 1e-22
BC016490-1|AAH16490.1| 1030|Homo sapiens MIB2 protein protein. 108 2e-22
AL691432-4|CAM12833.1| 919|Homo sapiens mindbomb homolog 2 (Dro... 108 2e-22
AL691432-3|CAM12832.1| 753|Homo sapiens mindbomb homolog 2 (Dro... 108 2e-22
AL691432-2|CAM12831.1| 999|Homo sapiens mindbomb homolog 2 (Dro... 108 2e-22
AL691432-1|CAM12830.1| 948|Homo sapiens mindbomb homolog 2 (Dro... 108 2e-22
AK098785-1|BAC05413.1| 802|Homo sapiens protein ( Homo sapiens ... 108 2e-22
AK097106-1|BAC04952.1| 819|Homo sapiens protein ( Homo sapiens ... 108 2e-22
AK096295-1|BAC04752.1| 681|Homo sapiens protein ( Homo sapiens ... 108 2e-22
AK095914-1|BAC04646.1| 681|Homo sapiens protein ( Homo sapiens ... 108 2e-22
AK091610-1|BAC03707.1| 645|Homo sapiens protein ( Homo sapiens ... 108 2e-22
AB097000-1|BAC77353.1| 999|Homo sapiens putative NFkB activatin... 108 2e-22
AB076693-1|BAC00994.1| 1009|Homo sapiens skeletrophin gamma prot... 108 2e-22
AB076692-1|BAC00993.1| 948|Homo sapiens skeletrophin beta protein. 108 2e-22
AB076691-1|BAC00992.1| 999|Homo sapiens skeletrophin alpha prot... 108 2e-22
AB074480-1|BAB92950.1| 1013|Homo sapiens skeletrophin protein. 108 2e-22
AB033081-1|BAA86569.2| 1232|Homo sapiens KIAA1255 protein protein. 108 2e-22
AK124559-1|BAC85884.1| 1005|Homo sapiens protein ( Homo sapiens ... 108 2e-22
DQ508815-1|ABF60230.1| 593|Homo sapiens SARP protein. 107 3e-22
BC037542-1|AAH37542.1| 999|Homo sapiens MIB2 protein protein. 107 3e-22
AB033076-1|BAA86564.2| 1777|Homo sapiens KIAA1250 protein protein. 107 3e-22
DQ822519-1|ABG46944.1| 835|Homo sapiens TNNI3 interacting kinas... 107 6e-22
BX470253-1|CAI16293.1| 835|Homo sapiens TNNI3 interacting kinas... 107 6e-22
BC117262-1|AAI17263.1| 835|Homo sapiens TNNI3 interacting kinas... 107 6e-22
BC113539-1|AAI13540.1| 835|Homo sapiens TNNI3 interacting kinas... 107 6e-22
BC032865-1|AAH32865.1| 843|Homo sapiens TNNI3K protein protein. 107 6e-22
AY303691-1|AAP72030.1| 835|Homo sapiens cardiac ankyrin repeat ... 107 6e-22
AF116826-1|AAD29632.1| 835|Homo sapiens putative protein-tyrosi... 107 6e-22
AB208941-1|BAD92178.1| 941|Homo sapiens TNNI3 interacting kinas... 107 6e-22
AF159164-1|AAD45345.1| 544|Homo sapiens ankyrin repeat-containi... 106 7e-22
EF041819-1|ABL09300.1| 782|Homo sapiens several ankyrin repeat ... 106 1e-21
BC130610-1|AAI30611.1| 1672|Homo sapiens KIDINS220 protein protein. 106 1e-21
BX640903-1|CAE45949.1| 714|Homo sapiens hypothetical protein pr... 105 1e-21
X69838-1|CAA49491.1| 1001|Homo sapiens G9a protein. 105 2e-21
BX005460-6|CAM26152.1| 922|Homo sapiens euchromatic histone-lys... 105 2e-21
BX005460-5|CAM26151.1| 888|Homo sapiens euchromatic histone-lys... 105 2e-21
BC020970-1|AAH20970.2| 1198|Homo sapiens EHMT2 protein protein. 105 2e-21
BC018718-1|AAH18718.1| 1001|Homo sapiens EHMT2 protein protein. 105 2e-21
BC009351-1|AAH09351.1| 1209|Homo sapiens EHMT2 protein protein. 105 2e-21
BC002686-1|AAH02686.2| 1043|Homo sapiens EHMT2 protein protein. 105 2e-21
BA000025-4|BAB63295.1| 1001|Homo sapiens G9A protein. 105 2e-21
AL844853-4|CAI41853.1| 1210|Homo sapiens HLA-B associated transc... 105 2e-21
AL844853-3|CAI41852.1| 1176|Homo sapiens HLA-B associated transc... 105 2e-21
AL671762-16|CAI18224.2| 1210|Homo sapiens euchromatic histone-ly... 105 2e-21
AL671762-15|CAI18226.2| 1176|Homo sapiens euchromatic histone-ly... 105 2e-21
AL671762-14|CAM25534.1| 1267|Homo sapiens euchromatic histone-ly... 105 2e-21
AL671762-13|CAM25533.1| 1233|Homo sapiens euchromatic histone-ly... 105 2e-21
AL662834-27|CAI17747.2| 1176|Homo sapiens euchromatic histone-ly... 105 2e-21
AL662834-26|CAI17748.1| 1210|Homo sapiens euchromatic histone-ly... 105 2e-21
AL662834-25|CAM24993.1| 1267|Homo sapiens euchromatic histone-ly... 105 2e-21
AL662834-24|CAM24992.1| 1233|Homo sapiens euchromatic histone-ly... 105 2e-21
AK222595-1|BAD96315.1| 518|Homo sapiens ankyrin repeat and SOCS... 105 2e-21
AJ315532-1|CAC86666.1| 1210|Homo sapiens NG36/G9a protein. 105 2e-21
AF134726-3|AAD21812.1| 1001|Homo sapiens G9A protein. 105 2e-21
BC110915-1|AAI10916.1| 553|Homo sapiens ASB3 protein protein. 104 3e-21
BC009569-1|AAH09569.1| 518|Homo sapiens ankyrin repeat and SOCS... 104 3e-21
BC006488-1|AAH06488.1| 518|Homo sapiens ankyrin repeat and SOCS... 104 3e-21
AK000985-1|BAA91455.1| 518|Homo sapiens protein ( Homo sapiens ... 104 3e-21
AF156778-1|AAD41895.1| 518|Homo sapiens ASB-3 protein protein. 104 3e-21
AC007883-1|AAY24350.1| 326|Homo sapiens unknown protein. 104 3e-21
AB209795-1|BAD93032.1| 340|Homo sapiens ankyrin repeat and SOCS... 104 3e-21
BC032354-1|AAH32354.1| 587|Homo sapiens ankyrin repeat and SOCS... 104 4e-21
BC030622-1|AAH30622.1| 301|Homo sapiens ankyrin repeat domain 2... 104 4e-21
AJ251238-1|CAC17765.1| 587|Homo sapiens hypothetical protein pr... 104 4e-21
AB056723-1|BAB64532.1| 587|Homo sapiens ankyrin repeat-conteini... 104 4e-21
BC101276-1|AAI01277.1| 420|Homo sapiens ANKDD1A protein protein. 103 5e-21
BC101274-1|AAI01275.1| 423|Homo sapiens ANKDD1A protein protein. 103 5e-21
BC101273-1|AAI01274.1| 399|Homo sapiens ANKDD1A protein protein. 103 5e-21
AB051515-1|BAB21819.1| 1644|Homo sapiens KIAA1728 protein protein. 103 7e-21
AK222715-1|BAD96435.1| 512|Homo sapiens ankyrin repeat and SOCS... 102 2e-20
BC028369-1|AAH28369.1| 617|Homo sapiens fem-1 homolog c (C. ele... 101 2e-20
AY249188-1|AAO64429.1| 617|Homo sapiens FEM1C protein. 101 2e-20
AL365415-1|CAB96957.1| 271|Homo sapiens similar to (NP_034322.1... 101 2e-20
AJ278120-1|CAB92314.1| 1101|Homo sapiens putative ankyrin-repeat... 101 2e-20
AF391093-1|AAL37627.1| 617|Homo sapiens FEM1A protein. 101 2e-20
AB058688-1|BAB47414.1| 617|Homo sapiens KIAA1785 protein protein. 101 2e-20
BC004988-1|AAH04988.1| 669|Homo sapiens fem-1 homolog a (C. ele... 100 6e-20
AY356352-1|AAR10439.1| 669|Homo sapiens prostaglandin E recepto... 100 6e-20
AJ311359-1|CAC85342.1| 668|Homo sapiens putative sex determinin... 100 6e-20
AL035288-1|CAA22892.1| 671|Homo sapiens hypothetical protein pr... 99 2e-19
AL021920-3|CAI19632.1| 671|Homo sapiens espin pseudogene protein. 99 2e-19
BX005460-4|CAM26150.1| 297|Homo sapiens euchromatic histone-lys... 98 3e-19
BC011608-1|AAH11608.2| 716|Homo sapiens EHMT1 protein protein. 98 3e-19
AY083210-1|AAM09024.1| 1267|Homo sapiens euchromatic histone met... 98 3e-19
AL671762-12|CAI18225.2| 297|Homo sapiens euchromatic histone-ly... 98 3e-19
AL662834-23|CAM24991.1| 297|Homo sapiens euchromatic histone-ly... 98 3e-19
AL611925-3|CAH71077.1| 1267|Homo sapiens euchromatic histone-lys... 98 3e-19
AL590627-3|CAI17355.1| 1267|Homo sapiens euchromatic histone-lys... 98 3e-19
AB209433-1|BAD92670.1| 1031|Homo sapiens HLA-B associated transc... 98 3e-19
AB058779-1|BAB47505.2| 803|Homo sapiens KIAA1876 protein protein. 98 3e-19
AB028932-1|BAB56104.1| 917|Homo sapiens GLP1 protein. 98 3e-19
D86982-1|BAA13218.1| 1180|Homo sapiens KIAA0229 protein. 98 3e-19
BC132832-1|AAI32833.1| 1134|Homo sapiens ankyrin repeat and ster... 98 3e-19
BC022396-1|AAH22396.1| 472|Homo sapiens Unknown (protein for IM... 98 3e-19
AL591002-1|CAI15138.1| 1134|Homo sapiens ankyrin repeat and ster... 98 3e-19
AL138721-1|CAI12437.1| 1134|Homo sapiens ankyrin repeat and ster... 98 3e-19
AL033520-2|CAI20281.1| 1134|Homo sapiens ankyrin repeat and ster... 98 3e-19
BC024189-1|AAH24189.2| 345|Homo sapiens fibronectin type III an... 97 6e-19
AY358154-1|AAQ88521.1| 371|Homo sapiens CG3104 hlg protein. 97 6e-19
AK127855-1|BAC87163.1| 337|Homo sapiens protein ( Homo sapiens ... 97 6e-19
BC052988-1|AAH52988.1| 980|Homo sapiens retinoic acid induced 1... 96 1e-18
AY354204-1|AAQ63889.2| 972|Homo sapiens retinoic acid induced 1... 96 1e-18
AY317139-1|AAP84319.1| 983|Homo sapiens RAI14 isoform protein. 96 1e-18
AK057782-1|BAB71569.1| 268|Homo sapiens protein ( Homo sapiens ... 96 1e-18
AF155135-1|AAF44722.1| 980|Homo sapiens novel retinal pigment e... 96 1e-18
AB037755-1|BAA92572.1| 989|Homo sapiens KIAA1334 protein protein. 96 1e-18
AY281131-1|AAP37612.1| 1249|Homo sapiens AIDA-1b protein. 95 2e-18
BC101620-1|AAI01621.1| 1001|Homo sapiens ankyrin repeat domain 3... 94 4e-18
BC101618-1|AAI01619.1| 1001|Homo sapiens ankyrin repeat domain 3... 94 4e-18
AK001283-1|BAA91599.1| 445|Homo sapiens protein ( Homo sapiens ... 94 4e-18
BC066643-1|AAH66643.1| 1202|Homo sapiens CASK interacting protei... 94 6e-18
AK098479-1|BAC05314.1| 353|Homo sapiens protein ( Homo sapiens ... 94 6e-18
AK091120-1|BAC03587.1| 1001|Homo sapiens protein ( Homo sapiens ... 94 6e-18
AF451976-1|AAL49757.1| 1202|Homo sapiens cask-interacting protei... 94 6e-18
AK095193-1|BAC04496.1| 389|Homo sapiens protein ( Homo sapiens ... 93 7e-18
DQ309791-1|ABC48694.1| 871|Homo sapiens SamCystin protein. 92 2e-17
AL807776-3|CAM13062.1| 871|Homo sapiens ankyrin repeat and ster... 92 2e-17
AL353782-4|CAM14169.1| 871|Homo sapiens ankyrin repeat and ster... 92 2e-17
DQ388145-2|ABD72216.1| 1482|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ388144-2|ABD72214.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ388143-2|ABD72212.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ388142-2|ABD72210.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ388141-2|ABD72208.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ388140-2|ABD72206.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ388139-2|ABD72204.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ388138-2|ABD72202.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ388137-2|ABD72200.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ388136-2|ABD72198.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ388135-2|ABD72196.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ388134-2|ABD72194.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ388133-2|ABD72192.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ388132-2|ABD72190.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ388131-2|ABD72188.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ388130-2|ABD72186.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ388129-2|ABD72184.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ388128-2|ABD72182.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ356264-2|ABC87066.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ356263-2|ABC87064.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ356262-2|ABC87062.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ356261-2|ABC87060.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ356260-2|ABC87058.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ356259-2|ABC87056.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ356258-2|ABC87054.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ356257-2|ABC87052.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ354391-2|ABC79055.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ354390-2|ABC79053.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ354389-2|ABC79051.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
DQ354388-2|ABC79049.1| 1663|Homo sapiens CTTNBP2 protein. 91 3e-17
BC106000-1|AAI06001.1| 1663|Homo sapiens cortactin binding prote... 91 3e-17
AF377960-1|AAL32176.1| 1663|Homo sapiens cortactin-binding prote... 91 3e-17
AB051545-1|BAB21849.1| 1662|Homo sapiens KIAA1758 protein protein. 91 3e-17
AB037360-1|BAA90300.1| 1166|Homo sapiens ANKHZN protein. 91 3e-17
BC107759-1|AAI07760.1| 360|Homo sapiens ankyrin repeat domain 2... 89 2e-16
AL359388-4|CAI14194.1| 333|Homo sapiens ankyrin repeat domain 2... 89 2e-16
AL355315-9|CAI15463.1| 333|Homo sapiens ankyrin repeat domain 2... 89 2e-16
AJ583444-1|CAE47432.1| 449|Homo sapiens ankyrin repeat protein ... 89 2e-16
AJ304805-1|CAC19412.1| 333|Homo sapiens skeletal muscle ankyrin... 89 2e-16
AJ304804-1|CAC19411.1| 333|Homo sapiens skeletal muscle ankyrin... 89 2e-16
AB058599-1|BAB60958.1| 333|Homo sapiens ankyrin-repeat protein ... 89 2e-16
AK125360-1|BAC86146.1| 588|Homo sapiens protein ( Homo sapiens ... 89 2e-16
AL834335-1|CAD39003.1| 407|Homo sapiens hypothetical protein pr... 87 5e-16
D83197-1|BAA34594.1| 226|Homo sapiens gankyrin protein. 87 6e-16
BC034982-1|AAH34982.1| 909|Homo sapiens HECT domain and ankyrin... 87 6e-16
BC011960-1|AAH11960.1| 226|Homo sapiens proteasome (prosome, ma... 87 6e-16
AL031177-5|CAA20117.1| 226|Homo sapiens proteasome (prosome, ma... 87 6e-16
AB009619-1|BAA33215.1| 226|Homo sapiens 26S proteasome subunit ... 87 6e-16
U95299-1|AAC32288.1| 2003|Homo sapiens Notch4 protein. 86 1e-15
U89335-1|AAC63097.1| 1999|Homo sapiens notch4 protein. 86 1e-15
D63395-1|BAA09708.1| 1095|Homo sapiens notch related protein pro... 86 1e-15
BX284927-1|CAM25850.1| 2003|Homo sapiens Notch homolog 4 (Drosop... 86 1e-15
BX284686-1|CAM26209.1| 2003|Homo sapiens Notch homolog 4 (Drosop... 86 1e-15
BC126351-1|AAI26352.1| 467|Homo sapiens ASB10 protein protein. 86 1e-15
AL845509-1|CAI18564.1| 2003|Homo sapiens Notch homolog 4 (Drosop... 86 1e-15
AL845464-12|CAI41803.1| 2003|Homo sapiens Notch homolog 4 (Droso... 86 1e-15
AL662884-27|CAI18362.1| 2003|Homo sapiens Notch homolog 4 (Droso... 86 1e-15
AL662830-9|CAI17543.1| 2005|Homo sapiens Notch homolog 4 (Drosop... 86 1e-15
AK125565-1|BAC86204.1| 452|Homo sapiens protein ( Homo sapiens ... 86 1e-15
AF417920-1|AAL59159.1| 429|Homo sapiens ASB-10 protein. 86 1e-15
Z47748-1|CAB94757.1| 969|Homo sapiens NFKB1 protein. 86 1e-15
U05681-1|AAC51348.1| 368|Homo sapiens B-cell leukemia/lymphoma ... 86 1e-15
M31732-1|AAA51815.1| 446|Homo sapiens BCL3 protein. 86 1e-15
BC064993-1|AAH64993.1| 446|Homo sapiens B-cell CLL/lymphoma 3 p... 86 1e-15
AB075861-1|BAB85567.1| 863|Homo sapiens KIAA1981 protein protein. 86 1e-15
M58603-1|AAA36360.1| 968|Homo sapiens nuclear factor kappa-B DN... 85 2e-15
M55643-1|AAA36361.1| 969|Homo sapiens factor KBF1 protein. 85 2e-15
BT019689-1|AAV38495.1| 226|Homo sapiens proteasome (prosome, ma... 85 2e-15
BC051765-1|AAH51765.1| 969|Homo sapiens nuclear factor of kappa... 85 2e-15
BC033210-1|AAH33210.1| 550|Homo sapiens NFKB1 protein protein. 85 2e-15
AY223820-1|AAO30127.1| 968|Homo sapiens nuclear factor of kappa... 85 2e-15
AK000904-1|BAA91417.1| 519|Homo sapiens protein ( Homo sapiens ... 85 2e-15
AF213884-1|AAF35232.1| 968|Homo sapiens nuclear factor of kappa... 85 2e-15
AB032965-1|BAA86453.1| 1124|Homo sapiens KIAA1139 protein protein. 85 3e-15
BC014558-1|AAH14558.1| 627|Homo sapiens fem-1 homolog b (C. ele... 84 6e-15
BC010122-1|AAH10122.1| 627|Homo sapiens fem-1 homolog b (C. ele... 84 6e-15
AF204883-1|AAF69303.1| 627|Homo sapiens FEM1 beta protein. 84 6e-15
AF178632-1|AAF05314.1| 627|Homo sapiens FEM-1-like death recept... 84 6e-15
AB007856-1|BAA23692.2| 627|Homo sapiens KIAA0396 protein. 84 6e-15
DQ508934-1|ABF57994.1| 591|Homo sapiens SARP3 protein. 83 8e-15
CR456543-1|CAG30429.1| 806|Homo sapiens PLA2G6 protein. 83 8e-15
BC051904-1|AAH51904.1| 752|Homo sapiens phospholipase A2, group... 83 8e-15
BC036742-1|AAH36742.2| 806|Homo sapiens phospholipase A2, group... 83 8e-15
AY522921-1|AAR92478.1| 806|Homo sapiens phospholipase A2, group... 83 8e-15
AL022322-2|CAA18446.1| 806|Homo sapiens phospholipase A2, group... 83 8e-15
AF117692-1|AAD30424.1| 806|Homo sapiens calcium-independent pho... 83 8e-15
AF116267-1|AAF34728.1| 806|Homo sapiens calcium-independent pho... 83 8e-15
AF102989-1|AAD41723.1| 806|Homo sapiens Ca2+-independent phosph... 83 8e-15
AF102988-1|AAD41722.1| 752|Homo sapiens Ca2+-independent phosph... 83 8e-15
AF064594-1|AAC97486.1| 806|Homo sapiens calcium-independent pho... 83 8e-15
BC027033-1|AAH27033.1| 448|Homo sapiens hypothetical protein MG... 83 1e-14
AL691467-2|CAH73760.1| 410|Homo sapiens novel protein protein. 83 1e-14
AL691467-1|CAH73759.1| 448|Homo sapiens novel protein protein. 83 1e-14
AL592424-19|CAI16391.1| 410|Homo sapiens novel protein protein. 83 1e-14
AL592424-18|CAI16392.1| 448|Homo sapiens novel protein protein. 83 1e-14
AL590133-27|CAI13351.1| 448|Homo sapiens novel protein protein. 83 1e-14
AL590133-26|CAI13352.1| 410|Homo sapiens novel protein protein. 83 1e-14
CR457302-1|CAG33583.1| 278|Homo sapiens ASB13 protein. 83 1e-14
AL365356-2|CAH72614.1| 278|Homo sapiens ankyrin repeat and SOCS... 83 1e-14
AF403031-1|AAL57350.1| 286|Homo sapiens ankyrin repeat domain-c... 83 1e-14
U97669-1|AAB91371.1| 2321|Homo sapiens Notch3 protein. 82 2e-14
AF058900-1|AAC14346.1| 2321|Homo sapiens Notch3 protein. 82 2e-14
AC004663-1|AAC15789.1| 2281|Homo sapiens Notch 3 protein. 82 2e-14
AK123496-1|BAC85629.1| 656|Homo sapiens protein ( Homo sapiens ... 81 6e-14
AK092230-1|BAC03833.1| 448|Homo sapiens ITOCHONDRIAL PRECURSOR.... 81 6e-14
AB075857-1|BAB85563.1| 606|Homo sapiens KIAA1977 protein protein. 81 6e-14
AK023196-1|BAB14456.1| 278|Homo sapiens ARPP-19) mRNA. protein. 80 7e-14
BC056152-1|AAH56152.1| 622|Homo sapiens zinc finger, DHHC-type ... 80 1e-13
BC036020-1|AAH36020.1| 622|Homo sapiens zinc finger, DHHC-type ... 80 1e-13
AL031177-4|CAI43134.1| 193|Homo sapiens proteasome (prosome, ma... 80 1e-13
AK001714-1|BAA91856.1| 481|Homo sapiens protein ( Homo sapiens ... 80 1e-13
AB097027-1|BAC77380.1| 622|Homo sapiens putative MAPK activatin... 80 1e-13
AB097014-1|BAC77367.1| 622|Homo sapiens putative NFkB activatin... 80 1e-13
AB024495-1|BAC22090.1| 622|Homo sapiens huntingtin interacting ... 80 1e-13
AK098736-1|BAC05399.1| 181|Homo sapiens protein ( Homo sapiens ... 79 1e-13
AY057056-1|AAL25260.1| 151|Homo sapiens hepatocellular carcinom... 79 2e-13
AL031177-6|CAI43131.1| 151|Homo sapiens proteasome (prosome, ma... 79 2e-13
L10381-1|AAA18032.1| 741|Homo sapiens 2-5A-dependent RNase prot... 79 2e-13
BC115697-1|AAI15698.1| 741|Homo sapiens ribonuclease L (2',5'-o... 79 2e-13
BC114433-1|AAI14434.1| 741|Homo sapiens ribonuclease L protein. 79 2e-13
BC090934-1|AAH90934.1| 652|Homo sapiens RNASEL protein protein. 79 2e-13
AL138776-1|CAH71322.1| 741|Homo sapiens ribonuclease L (2',5'-o... 79 2e-13
BC050324-1|AAH50324.1| 632|Homo sapiens zinc finger, DHHC-type ... 78 3e-13
AB097035-1|BAC77388.1| 622|Homo sapiens putative MAPK activatin... 78 3e-13
AB097013-1|BAC77366.1| 622|Homo sapiens putative NFkB activatin... 78 3e-13
AB023163-1|BAA76790.1| 667|Homo sapiens KIAA0946 protein protein. 78 3e-13
BC113409-1|AAI13410.1| 1416|Homo sapiens uveal autoantigen with ... 78 4e-13
BC113407-1|AAI13408.1| 1416|Homo sapiens uveal autoantigen with ... 78 4e-13
BC100877-1|AAI00878.1| 241|Homo sapiens ASB15 protein protein. 78 4e-13
BC100876-1|AAI00877.1| 241|Homo sapiens ASB15 protein protein. 78 4e-13
BC100875-1|AAI00876.1| 241|Homo sapiens ASB15 protein protein. 78 4e-13
BC100874-1|AAI00875.1| 241|Homo sapiens ASB15 protein protein. 78 4e-13
BC016881-1|AAH16881.1| 638|Homo sapiens Unknown (protein for IM... 78 4e-13
AK055435-1|BAB70922.1| 634|Homo sapiens protein ( Homo sapiens ... 78 4e-13
AB046781-1|BAB13387.2| 1416|Homo sapiens KIAA1561 protein protein. 78 4e-13
X54457-1|CAA38325.1| 745|Homo sapiens protein ( Human mRNA for ... 77 5e-13
S79774-1|AAB35488.2| 742|Homo sapiens bile salt-dependent lipas... 77 5e-13
M94579-1|AAA51973.1| 745|Homo sapiens carboxyl ester lipase pro... 77 5e-13
M85201-1|AAA52014.1| 747|Homo sapiens cholesterol esterase prot... 77 5e-13
M54994-1|AAA63211.1| 742|Homo sapiens bile salt-activated lipas... 77 5e-13
BC113481-1|AAI13482.1| 349|Homo sapiens ankyrin repeat and SOCS... 77 5e-13
BC113479-1|AAI13480.1| 349|Homo sapiens ankyrin repeat and SOCS... 77 5e-13
BC042510-1|AAH42510.1| 722|Homo sapiens CEL protein protein. 77 5e-13
BC025024-1|AAH25024.1| 318|Homo sapiens Unknown (protein for IM... 77 5e-13
AL162417-8|CAI13412.1| 756|Homo sapiens carboxyl ester lipase (... 77 5e-13
AF156779-1|AAD41896.1| 426|Homo sapiens ASB-4 protein protein. 77 5e-13
AF081673-1|AAC71012.1| 612|Homo sapiens bile salt-dependent lip... 77 5e-13
AF072711-1|AAC26514.1| 745|Homo sapiens carboxyl ester lipase p... 77 5e-13
AC003079-1|AAB83943.2| 426|Homo sapiens unknown protein. 77 5e-13
D79994-1|BAA11489.2| 1366|Homo sapiens KIAA0172 protein. 77 7e-13
BX537853-1|CAD97861.1| 302|Homo sapiens hypothetical protein pr... 77 7e-13
BC131801-1|AAI31802.1| 567|Homo sapiens protein phosphatase 1, ... 77 7e-13
BC126188-1|AAI26189.1| 475|Homo sapiens ankyrin repeat, SAM and... 77 7e-13
BC126186-1|AAI26187.1| 475|Homo sapiens ankyrin repeat, SAM and... 77 7e-13
BC103875-1|AAI03876.1| 323|Homo sapiens ankyrin repeat and SOCS... 77 7e-13
BC103874-1|AAI03875.1| 323|Homo sapiens ankyrin repeat and SOCS... 77 7e-13
BC069340-1|AAH69340.1| 323|Homo sapiens ankyrin repeat and SOCS... 77 7e-13
BC063581-1|AAH63581.1| 274|Homo sapiens ankyrin repeat and SOCS... 77 7e-13
BC038116-1|AAH38116.1| 1194|Homo sapiens ankyrin repeat domain 1... 77 7e-13
BC037495-1|AAH37495.1| 1352|Homo sapiens ANKRD15 protein protein. 77 7e-13
BC034963-1|AAH34963.1| 393|Homo sapiens ASZ1 protein protein. 77 7e-13
BC020040-1|AAH20040.1| 784|Homo sapiens ANKRD15 protein protein. 77 7e-13
AL136979-6|CAH70390.1| 276|Homo sapiens ankyrin repeat domain 1... 77 7e-13
AL136979-5|CAH70389.1| 330|Homo sapiens ankyrin repeat domain 1... 77 7e-13
AL136979-4|CAM13084.1| 1194|Homo sapiens ankyrin repeat domain 1... 77 7e-13
AL136979-3|CAH70388.1| 1352|Homo sapiens ankyrin repeat domain 1... 77 7e-13
AL121889-1|CAI19080.1| 567|Homo sapiens protein phosphatase 1, ... 77 7e-13
AL031657-1|CAI20058.1| 567|Homo sapiens protein phosphatase 1, ... 77 7e-13
AK222974-1|BAD96694.1| 274|Homo sapiens ankyrin repeat and SOCS... 77 7e-13
AK222958-1|BAD96678.1| 274|Homo sapiens ankyrin repeat and SOCS... 77 7e-13
AK093445-1|BAC04167.1| 475|Homo sapiens protein ( Homo sapiens ... 77 7e-13
AK026204-1|BAB15392.1| 274|Homo sapiens protein ( Homo sapiens ... 77 7e-13
AF461259-1|AAL68815.1| 475|Homo sapiens GASZ protein. 77 7e-13
AF451994-1|AAP97683.1| 318|Homo sapiens ankyrin repeat-containi... 77 7e-13
AF425642-1|AAL60519.1| 323|Homo sapiens ankyrin repeat domain-c... 77 7e-13
AF362910-1|AAK52796.1| 567|Homo sapiens CAAX box protein TIMAP ... 77 7e-13
AB020630-1|BAA74846.2| 578|Homo sapiens KIAA0823 protein protein. 77 7e-13
U13048-1|AAA65710.1| 348|Homo sapiens nuclear respiratory facto... 77 9e-13
U13047-1|AAA65709.1| 360|Homo sapiens nuclear respiratory facto... 77 9e-13
U13046-1|AAA65708.1| 383|Homo sapiens nuclear respiratory facto... 77 9e-13
U13045-1|AAA65707.1| 395|Homo sapiens nuclear respiratory facto... 77 9e-13
D13317-1|BAA02574.1| 383|Homo sapiens transcription factor E4TF... 77 9e-13
D13316-1|BAA02573.1| 347|Homo sapiens transcription factor E4TF... 77 9e-13
DQ224339-1|ABB02425.1| 618|Homo sapiens Ikappa B-zeta variant 3... 77 9e-13
BT006652-1|AAP35298.1| 360|Homo sapiens GA binding protein tran... 77 9e-13
BC117367-1|AAI17368.1| 264|Homo sapiens ankyrin repeat domain 1... 77 9e-13
BC060800-1|AAH60800.1| 718|Homo sapiens nuclear factor of kappa... 77 9e-13
BC050702-1|AAH50702.1| 395|Homo sapiens GA binding protein tran... 77 9e-13
BC038951-1|AAH38951.1| 264|Homo sapiens ANKRD19 protein protein. 77 9e-13
BC036080-1|AAH36080.1| 383|Homo sapiens GA binding protein tran... 77 9e-13
BC028712-1|AAH28712.1| 264|Homo sapiens ANKRD19 protein protein. 77 9e-13
BC016910-1|AAH16910.1| 360|Homo sapiens GA binding protein tran... 77 9e-13
AL159174-2|CAI39610.1| 640|Homo sapiens ankyrin repeat domain 6... 77 9e-13
AL136981-3|CAC12726.1| 264|Homo sapiens ankyrin repeat domain 1... 77 9e-13
AL096678-3|CAI42281.1| 640|Homo sapiens ankyrin repeat domain 6... 77 9e-13
AF548362-1|AAN40698.1| 618|Homo sapiens MAIL-S protein. 77 9e-13
AB037925-1|BAB40337.1| 718|Homo sapiens MAIL protein. 77 9e-13
AB024494-1|BAC22089.1| 633|Homo sapiens huntingtin interacting ... 77 9e-13
AL117504-1|CAB55968.1| 641|Homo sapiens hypothetical protein pr... 76 1e-12
AF312028-1|AAG60045.1| 782|Homo sapiens myosin binding subunit ... 76 1e-12
AB209452-1|BAD92689.1| 736|Homo sapiens protein phosphatase 1, ... 76 1e-12
BC045621-1|AAH45621.1| 198|Homo sapiens ANKRD42 protein protein. 76 2e-12
AK091782-1|BAC03746.1| 596|Homo sapiens protein ( Homo sapiens ... 76 2e-12
M69043-1|AAA16489.1| 317|Homo sapiens MAD3 protein. 75 3e-12
BT007091-1|AAP35754.1| 317|Homo sapiens nuclear factor of kappa... 75 3e-12
BC004983-1|AAH04983.1| 317|Homo sapiens nuclear factor of kappa... 75 3e-12
BC002601-1|AAH02601.1| 317|Homo sapiens nuclear factor of kappa... 75 3e-12
AY496422-1|AAR29599.1| 317|Homo sapiens nuclear factor of kappa... 75 3e-12
AY033600-1|AAK51149.1| 317|Homo sapiens NFKBIA protein. 75 3e-12
AL357148-2|CAI16567.1| 1341|Homo sapiens breast cancer antigen N... 75 3e-12
AL357148-1|CAI16568.1| 1460|Homo sapiens ankyrin repeat domain 3... 75 3e-12
AL157387-4|CAH71319.1| 1460|Homo sapiens ankyrin repeat domain 3... 75 3e-12
AL157387-3|CAH71320.1| 1341|Homo sapiens breast cancer antigen N... 75 3e-12
AJ249294-1|CAB65556.2| 317|Homo sapiens IkBa protein. 75 3e-12
AF308292-1|AAG48260.1| 352|Homo sapiens serologically defined b... 75 3e-12
BC126428-1|AAI26429.1| 777|Homo sapiens BRCA1 associated RING d... 75 4e-12
U76638-1|AAB38316.1| 777|Homo sapiens BRCA1-associated RING dom... 74 5e-12
BC126426-1|AAI26427.1| 777|Homo sapiens BRCA1 associated RING d... 74 5e-12
BC070234-1|AAH70234.1| 371|Homo sapiens ANKRD12 protein protein. 74 5e-12
BC030990-1|AAH30990.1| 276|Homo sapiens ZDHHC17 protein protein. 74 5e-12
BC012056-1|AAH12056.1| 173|Homo sapiens ASB13 protein protein. 74 5e-12
AY533564-1|AAS45545.2| 2039|Homo sapiens ankyrin repeat-containi... 74 5e-12
AY373757-1|AAR25662.1| 2062|Homo sapiens ankyrin repeat-containi... 74 5e-12
AL590402-2|CAH74024.1| 903|Homo sapiens HECT domain and ankyrin... 74 5e-12
AL513472-2|CAH71890.1| 903|Homo sapiens HECT domain and ankyrin... 74 5e-12
AL357315-1|CAI16815.1| 903|Homo sapiens HECT domain and ankyrin... 74 5e-12
AK223409-1|BAD97129.1| 777|Homo sapiens BRCA1 associated RING d... 74 5e-12
AK024808-1|BAB15014.1| 492|Homo sapiens protein ( Homo sapiens ... 74 5e-12
AF322916-1|AAG49577.1| 1416|Homo sapiens uveal autoantigen protein. 74 5e-12
AF317425-1|AAG38609.1| 2062|Homo sapiens GAC-1 protein. 74 5e-12
AF038042-1|AAB99978.1| 777|Homo sapiens BRCA1-associated RING d... 74 5e-12
AC016708-1|AAX93130.1| 777|Homo sapiens unknown protein. 74 5e-12
BC057225-1|AAH57225.1| 330|Homo sapiens ANKRD12 protein protein. 74 6e-12
AY462873-1|AAS58867.1| 376|Homo sapiens POTE2C protein. 74 6e-12
AY462871-1|AAS58865.1| 712|Homo sapiens POTE2A protein. 74 6e-12
AY462868-1|AAS58862.1| 376|Homo sapiens POTE2D protein. 74 6e-12
U40282-1|AAC16892.1| 452|Homo sapiens integrin-linked kinase pr... 73 8e-12
CR545463-1|CAM28350.1| 545|Homo sapiens protein expressed in pr... 73 8e-12
CR457336-1|CAG33617.1| 288|Homo sapiens ASB8 protein. 73 8e-12
CR407673-1|CAG28601.1| 452|Homo sapiens ILK protein. 73 8e-12
BC127623-1|AAI27624.1| 458|Homo sapiens ACTBL1 protein protein. 73 8e-12
BC001554-1|AAH01554.1| 452|Homo sapiens integrin-linked kinase ... 73 8e-12
BC001321-1|AAH01321.1| 288|Homo sapiens ankyrin repeat and SOCS... 73 8e-12
AY465172-1|AAS58871.1| 486|Homo sapiens POTE14C protein. 73 8e-12
AY462874-1|AAS58868.1| 508|Homo sapiens POTE14A protein. 73 8e-12
AK024908-1|BAB15033.1| 288|Homo sapiens NP3) mRNA. protein. 73 8e-12
AJ404847-1|CAB99253.1| 452|Homo sapiens integrin-linked kinase ... 73 8e-12
AJ277481-1|CAB94832.1| 452|Homo sapiens integrin-linked kinase-... 73 8e-12
AF244139-1|AAF74449.1| 452|Homo sapiens integrin-linked kinase ... 73 8e-12
D87930-1|BAA22378.1| 1030|Homo sapiens myosin phosphatase target... 73 1e-11
BC111752-1|AAI11753.1| 1030|Homo sapiens PPP1R12A protein protein. 73 1e-11
BC107056-1|AAI07057.1| 305|Homo sapiens ankyrin repeat domain 2... 73 1e-11
BC092481-1|AAH92481.1| 730|Homo sapiens PPP1R12A protein protein. 73 1e-11
BC047898-1|AAH47898.1| 692|Homo sapiens PPP1R12A protein protein. 73 1e-11
AY380574-1|AAQ88438.1| 974|Homo sapiens myosin phosphatase targ... 73 1e-11
AY196212-1|AAO40750.1| 305|Homo sapiens muscle ankyrin repeat p... 73 1e-11
AK092564-1|BAC03915.1| 263|Homo sapiens protein ( Homo sapiens ... 73 1e-11
AJ315766-1|CAC86120.1| 296|Homo sapiens Ankyrin repeat-containi... 73 1e-11
AF492401-1|AAO24067.1| 305|Homo sapiens diabetes related ankyri... 73 1e-11
AF458589-1|AAM49717.1| 995|Homo sapiens myosin phosphatase targ... 73 1e-11
AC092636-3|AAY14965.1| 305|Homo sapiens unknown protein. 73 1e-11
BC069013-1|AAH69013.1| 457|Homo sapiens ANKRD11 protein protein. 73 1e-11
BC066981-1|AAH66981.1| 381|Homo sapiens POTE15 protein protein. 73 1e-11
AY533563-1|AAS45544.1| 2663|Homo sapiens ankyrin repeat-containi... 73 1e-11
AY373756-1|AAR25661.1| 2664|Homo sapiens ankyrin repeat-containi... 73 1e-11
AF269087-1|AAK27325.1| 1341|Homo sapiens breast cancer antigen N... 73 1e-11
AB209186-1|BAD92423.1| 439|Homo sapiens ankyrin repeat domain 1... 73 1e-11
EF523384-1|ABP57734.1| 1075|Homo sapiens POTE-2 alpha-actin prot... 72 2e-11
AF121775-1|AAF24125.1| 366|Homo sapiens nasopharyngeal carcinom... 72 2e-11
M73980-1|AAA60614.1| 2444|Homo sapiens TAN1 protein. 72 3e-11
BC104946-1|AAI04947.1| 309|Homo sapiens ankyrin repeat and SOCS... 72 3e-11
>U13616-1|AAA64834.1| 4377|Homo sapiens ankyrin G protein.
Length = 4377
Score = 318 bits (782), Expect = 1e-85
Identities = 229/752 (30%), Positives = 377/752 (50%), Gaps = 37/752 (4%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H A++ GHV +++ LLQ+ +VD T TALHIA + + VV+ L+ GA+
Sbjct: 73 NGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGAN 132
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V+ + + TPL++AA+ + + LL +GA + ATEDG TP+ VA + G+ +
Sbjct: 133 VNAQS-QNGFTPLYMAAQ-ENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVS 190
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDI---VRHLIEFVKDHKGESVSTA 838
LLLE+ D K ++ + + + A D V F H
Sbjct: 191 LLLEN--DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNI 248
Query: 839 FIDAVDEDGASALHYACK--VTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHY 896
+ + + A+A+ + + +T V + +VK L++ GA + +TR T H
Sbjct: 249 NVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGL-TPLHC 307
Query: 897 CAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVD 956
A +G+ V+ EM+ + +S+ N G +PL +A H+ V LL ++ VD
Sbjct: 308 GARSGHEQVV-EMLLDRAAPILSKTKN-----GLSPLHMATQGDHLNCVQLLLQHNVPVD 361
Query: 957 VFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIR 1016
+ +ALH+AA G+ +V LL KA N+KA NG T LH+A +++ L++
Sbjct: 362 DVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLK 421
Query: 1017 DHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSE 1076
H A I +T TP+H+AA G + + L+ GA+ + T+ G+ +H AA++ +E
Sbjct: 422 -HGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAE 480
Query: 1077 VVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPL 1136
VV+ +L Q V A KD T HI+A G ++++L++ G + TPL
Sbjct: 481 VVR-YLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQ---QGASPNAATTSGYTPL 536
Query: 1137 QLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
L+A GH DV L+ GAS + + G T +H+AA++G V +++ + ++ K
Sbjct: 537 HLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGK 596
Query: 1197 LGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGN 1256
GLTPLH+AA+Y + LL G S P A++G TPLH+AA
Sbjct: 597 SGLTPLHVAAHYDNQKVALLLLDQ-----------GAS--PHAAAKNGYTPLHIAAKKNQ 643
Query: 1257 ENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTG 1316
++ LL G A+A + + G +HLA GH+ +V LLL R+A + + +++ G T
Sbjct: 644 MDIATTLLEY-GADANAVTRQ-GIASVHLAAQEGHVDMVSLLLGRNANV-NLSNKSGLTP 700
Query: 1317 LHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSET 1376
LH+A+ + EVL+ QGA ++A K G+TPLH G++ +V L + A ++T
Sbjct: 701 LHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKT 760
Query: 1377 NLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
P+ AA + H ++ LL L
Sbjct: 761 KNGYTPLHQAAQQGHTHIINVLLQNNASPNEL 792
Score = 297 bits (728), Expect = 4e-79
Identities = 229/764 (29%), Positives = 366/764 (47%), Gaps = 67/764 (8%)
Query: 656 EKYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETL 715
++ K D S AAR GH+ ++ G +++ + ALH+A + VV L
Sbjct: 34 DRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSEL 93
Query: 716 LGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
L A+V K+ T LHIA+ + + +L+ +GA N +++G TP+++AA+
Sbjct: 94 LQREANVD-AATKKGNTALHIAS-LAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQEN 151
Query: 776 NLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESV 835
+L + LL++G T+ G TPL +A + +V L+E D KG+
Sbjct: 152 HLEVVKFLLDNGASQSLATE-------DGFTPLAVALQQGHDQVVSLLLE--NDTKGKV- 201
Query: 836 STAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFH 895
ALH A + K++ K L++N + ++++ T H
Sbjct: 202 -----------RLPALHIAAR--KDDTK-------AAALLLQNDNNADVESKSGF-TPLH 240
Query: 896 YCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARV 955
A GN +V T ++ + D +N I TPL +A RG+ +V LL A++
Sbjct: 241 IAAHYGNINVATLLLNRAAAVD----FTARNDI--TPLHVASKRGNANMVKLLLDRGAKI 294
Query: 956 DVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLI 1015
D +G + LH A G+ QV + LL A I SK +NG + LH+A + + V+ L+
Sbjct: 295 DAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLL 354
Query: 1016 RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYS 1075
+ HN +D +T T LH+AA G +V K+LL+ AN +A G P+H A + N
Sbjct: 355 Q-HNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRI 413
Query: 1076 EVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTP 1135
+V++L L +H + A T+ G T H+AA G V ++ +LM G + T
Sbjct: 414 KVMELLL-KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLM---HHGASPNTTNVRGETA 469
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK 1195
L +AA G A+VVR LV+ GA + + T +H++A G +++ + ++
Sbjct: 470 LHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAAT 529
Query: 1196 KLGLTPLHIAAYYGQAETVRELLSHVPG----TVKSEAPTGV----------------SL 1235
G TPLH++A G + LL H T K P V S
Sbjct: 530 TSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSA 589
Query: 1236 VPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIV 1295
P +SGLTPLH+AA+ N+ V LLL+ G AA+ +NGY PLH+A M I
Sbjct: 590 SPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ-GASPHAAA-KNGYTPLHIAAKKNQMDIA 647
Query: 1296 GLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAK 1355
LL A+ ++ R G +H+A+ GH MV +LLG+ A +N ++K+G TPLH AA+
Sbjct: 648 TTLLEYGAD-ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQ 706
Query: 1356 AGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+NV ++L GA ++T + P+ + ++ +LL
Sbjct: 707 EDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLL 750
Score = 270 bits (662), Expect = 4e-71
Identities = 214/721 (29%), Positives = 349/721 (48%), Gaps = 61/721 (8%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++ AA+ H+ ++ LL G S + T D +T L +A++ VV LL
Sbjct: 139 NGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTK 198
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
GK R LHIAAR D K A +LL++ + ++ G TP+H+AA +GN+
Sbjct: 199 -----GKVRLPALHIAAR-KDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVAT 252
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LLL + + TPL +A + ++V+ L++ +G A ID
Sbjct: 253 LLLN-------RAAAVDFTARNDITPLHVASKRGNANMVKLLLD-----RG-----AKID 295
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQV-VKCLIENG-ADVSLQTRHNHETAF----- 894
A DG + LH + E+V DR + +NG + + + T+ +H
Sbjct: 296 AKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ 355
Query: 895 HYCAIAG-NNDVMTEM--IAHISTADVSRAL-------NRQNSIGWTPLLIACHRGHMQL 944
H + ND +T + AH V++ L N + G+TPL IAC + +++
Sbjct: 356 HNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKV 415
Query: 945 VNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAM 1004
+ LL + A + G + +H+AA G++ + L+ + A N+ G TALH+AA
Sbjct: 416 MELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAAR 475
Query: 1005 NGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQK 1064
+G A +V++L++D A ++ QTPLH++A G+ ++ + LL+ GA+ +A G
Sbjct: 476 SGQAEVVRYLVQD-GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYT 534
Query: 1065 PIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVI 1124
P+H +A+ + +V FL H + TTK G T H+AA G ++V L++ +
Sbjct: 535 PLHLSAREGHEDVAA-FLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDA 593
Query: 1125 SARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ ++ L TPL +AA + V +L+ GAS + G T +H+AA+ ++ +
Sbjct: 594 AGKSGL---TPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL 650
Query: 1185 RSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESG 1244
+ + G+ +H+AA G + V LL G + L +SG
Sbjct: 651 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL-------------GRNANVNLSNKSG 697
Query: 1245 LTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAE 1304
LTPLHLAA NV +L+N G DA + + GY PLH+ C G++ IV LL SA+
Sbjct: 698 LTPLHLAAQEDRVNVAEVLVNQ-GAHVDAQT-KMGYTPLHVGCHYGNIKIVNFLLQHSAK 755
Query: 1305 LLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKL 1364
+ T ++G T LH A+ GH ++ VLL A N NG T L A + G+++VV
Sbjct: 756 VNAKT-KNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDT 814
Query: 1365 L 1365
L
Sbjct: 815 L 815
Score = 256 bits (628), Expect = 5e-67
Identities = 217/731 (29%), Positives = 349/731 (47%), Gaps = 69/731 (9%)
Query: 737 AARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKV 796
AAR +K AL +K+G N ++G+ +H+A+K G++ + LL+ + TK
Sbjct: 48 AARAGHLEK-ALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATK- 105
Query: 797 CIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACK 856
G T L +A + ++V+ L+ + A ++A ++G + L+ A +
Sbjct: 106 ------KGNTALHIASLAGQAEVVKVLV----------TNGANVNAQSQNGFTPLYMAAQ 149
Query: 857 VTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTA 916
EV VK L++NGA SL T T G++ V++ ++ +
Sbjct: 150 ENHLEV---------VKFLLDNGASQSLATEDGF-TPLAVALQQGHDQVVSLLLEN---- 195
Query: 917 DVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQ 976
+ + + L IA + + LL N DV G + LH+AA +G +
Sbjct: 196 ------DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNIN 249
Query: 977 VCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLA 1036
V LL A ++ ARN T LH+A+ G A++VK L+ D A ID T TPLH
Sbjct: 250 VATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLL-DRGAKIDAKTRDGLTPLHCG 308
Query: 1037 AASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDG 1096
A SG +V ++LL+ A I + + G P+H A Q ++ VQL LQ H V T D
Sbjct: 309 ARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ-HNVPVDDVTNDY 367
Query: 1097 NTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGA 1156
T H+AA G KV + L+ D+ +A+ LN TPL +A + V+ +L++ GA
Sbjct: 368 LTALHVAAHCGHYKVAKVLL--DKKANPNAK-ALNGFTPLHIACKKNRIKVMELLLKHGA 424
Query: 1157 SCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRE 1216
S +GLT +H+AA GH N++ + ++ G T LH+AA GQAE VR
Sbjct: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484
Query: 1217 LL---SHVPGTVKSE-APTGVSL----------------VPVLGAESGLTPLHLAAYNGN 1256
L+ + V K + P +S P SG TPLHL+A G+
Sbjct: 485 LVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGH 544
Query: 1257 ENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTG 1316
E+V LL+ + + + + G+ PLH+A G + + LLL +SA + + G T
Sbjct: 545 EDVAAFLLDHGA--SLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP-DAAGKSGLTP 601
Query: 1317 LHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSET 1376
LH+A+ + + ++ +LL QGA +A KNG+TPLH AAK +++ L E GA + T
Sbjct: 602 LHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVT 661
Query: 1377 NLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLV 1436
A + AA E H D++ LL + + + +K + L + ++ + + + E ++
Sbjct: 662 RQGIASVHLAAQEGHVDMVSLLLGRNANVN--LSNKSGLTPLHLAAQ-EDRVNVAEVLVN 718
Query: 1437 SPAPVDTAAKL 1447
A VD K+
Sbjct: 719 QGAHVDAQTKM 729
Score = 241 bits (591), Expect = 1e-62
Identities = 195/664 (29%), Positives = 324/664 (48%), Gaps = 63/664 (9%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA YG++ + LL + +VD T ++ T LH+A + +V+ LL GA +
Sbjct: 235 GFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKI 294
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + TPLH AR ++ MLL A T++G++P+H+A + +L + L
Sbjct: 295 DAKT-RDGLTPLHCGAR-SGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQL 352
Query: 783 LLEDGGDPLRKTKVCIYDVVTGE-TPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LL+ V + DV T L +A + + L+ D K + A
Sbjct: 353 LLQHN--------VPVDDVTNDYLTALHVAAHCGHYKVAKVLL----DKKANPNAKAL-- 398
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
+G + LH ACK K +K V++ L+++GA + T T H A G
Sbjct: 399 ----NGFTPLHIACK--KNRIK-------VMELLLKHGASIQAVTESGL-TPIHVAAFMG 444
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ +++++++ H ++ N N G T L +A G ++V L+ + A+V+ +
Sbjct: 445 HVNIVSQLMHHGASP------NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKD 498
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM 1021
++ LH++A G + LL A N+ +G T LHL+A G+ + FL+ DH A
Sbjct: 499 DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLL-DHGAS 557
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
+ + T K TPLH+AA G++EV LLL+ A+ DA + G P+H AA + +V L
Sbjct: 558 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 617
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L Q + A K+G T HIAA + + + L+++ R + + LAA+
Sbjct: 618 LDQGAS-PHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGI---ASVHLAAQ 673
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTP 1201
GH D+V +L+ A+ N++GLT +HLAA+ NV +V+ + + K+G TP
Sbjct: 674 EGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTP 733
Query: 1202 LHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVR 1261
LH+ +YG + V LL H + K A T ++G TPLH AA G+ +++
Sbjct: 734 LHVGCHYGNIKIVNFLLQH---SAKVNAKT----------KNGYTPLHQAAQQGHTHIIN 780
Query: 1262 LLLNSAGVQADAASNE---NGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH 1318
+LL Q +A+ NE NG L +A G++S+V L + E + +T K ++
Sbjct: 781 VLL-----QNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMN 835
Query: 1319 IAST 1322
+ T
Sbjct: 836 VPET 839
Score = 233 bits (570), Expect = 5e-60
Identities = 173/562 (30%), Positives = 278/562 (49%), Gaps = 60/562 (10%)
Query: 934 LIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKAR 993
L A GH++ + N +++ + G +ALHLA++ G+++V LL +A +++ +
Sbjct: 46 LRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATK 105
Query: 994 NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA 1053
G TALH+A++ G A +VK L+ + A ++ + TPL++AA +EV K LL+ GA
Sbjct: 106 KGNTALHIASLAGQAEVVKVLV-TNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGA 164
Query: 1054 NIDATDELGQKPIHAAAQNNYSEVVQLFLQQH-------PNLVMATTKD----------- 1095
+ E G P+ A Q + +VV L L+ P L +A KD
Sbjct: 165 SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQN 224
Query: 1096 ----------GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA 1145
G T HIAA G++ V L+ +AR ND TPL +A++ G+A
Sbjct: 225 DNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTAR---NDITPLHVASKRGNA 281
Query: 1146 DVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIA 1205
++V++L+ GA + R GLT +H A GH V++++ +S K GL+PLH+A
Sbjct: 282 NMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMA 341
Query: 1206 AYYGQAETVRELLSH-VP-GTVKSEAPTGVSLV------------------PVLGAESGL 1245
V+ LL H VP V ++ T + + P A +G
Sbjct: 342 TQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGF 401
Query: 1246 TPLHLAAYNGNENVVRLLL-NSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAE 1304
TPLH+A V+ LLL + A +Q A E+G P+H+A F GH++IV L+ A
Sbjct: 402 TPLHIACKKNRIKVMELLLKHGASIQ---AVTESGLTPIHVAAFMGHVNIVSQLMHHGAS 458
Query: 1305 LLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKL 1364
++T+ G+T LH+A+ G ++V L+ GA++ A K+ TPLH +A+ G ++V+
Sbjct: 459 -PNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQ 517
Query: 1365 LCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKN 1424
L + GASP + T P+ +A E H DV +LL +H + K+ L V +K
Sbjct: 518 LLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLL--DHGASLSITTKKGFTPLHVAAK- 574
Query: 1425 HNNIPIEEFVLVSPAPVDTAAK 1446
+ + + +L A D A K
Sbjct: 575 YGKLEVANLLLQKSASPDAAGK 596
Score = 159 bits (385), Expect = 1e-37
Identities = 128/458 (27%), Positives = 211/458 (46%), Gaps = 39/458 (8%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K +G +H A + + ++ LL+ G S+ T T +H+A +V L+ +
Sbjct: 396 KALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHH 455
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
GA + + ET LH+AAR + L++ GA +D TP+H++A+ G
Sbjct: 456 GASPNTT-NVRGETALHMAARSGQAE-VVRYLVQDGAQVEAKAKDDQTPLHISARLGKAD 513
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LL+ G P T +G TPL ++ R D+ F+ DH G S+S
Sbjct: 514 IVQQLLQQGASPNAAT-------TSGYTPLHLSAREGHEDVA----AFLLDH-GASLS-- 559
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVS-LQTRHNHETAFHYC 897
+ G + LH A K K EV A+ + K + A S L H A HY
Sbjct: 560 ---ITTKKGFTPLHVAAKYGKLEV----ANLLLQKSASPDAAGKSGLTPLH---VAAHY- 608
Query: 898 AIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
+N + ++ + + A N G+TPL IA + M + TLL A +
Sbjct: 609 ----DNQKVALLLLDQGASPHAAAKN-----GYTPLHIAAKKNQMDIATTLLEYGADANA 659
Query: 958 FDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRD 1017
+G +++HLAA+ G++ + LL A +N ++G T LHLAA ++ + L+ +
Sbjct: 660 VTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLV-N 718
Query: 1018 HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEV 1077
A +D T TPLH+ G I++ LL+ A ++A + G P+H AAQ ++ +
Sbjct: 719 QGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHI 778
Query: 1078 VQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEEL 1115
+ + LQ + + T +GNT IA G + V++ L
Sbjct: 779 INVLLQNNAS-PNELTVNGNTALGIARRLGYISVVDTL 815
Score = 87.0 bits (206), Expect = 6e-16
Identities = 55/162 (33%), Positives = 83/162 (51%), Gaps = 3/162 (1%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V + G P+ +A G+ ++V +L+ + T G+TALH+AAR ++ R LV
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPN--TTNVRGETALHMAARSGQAEVVRYLV 486
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
GA V+A QTPLHI+A G +V+ A+ A TP+HL+A GH
Sbjct: 487 QDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHED 546
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+ L D AS+ TK G T +H+A+ G + A +L +K
Sbjct: 547 VAAFLLD-HGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK 587
Score = 85.8 bits (203), Expect = 1e-15
Identities = 49/162 (30%), Positives = 81/162 (50%), Gaps = 2/162 (1%)
Query: 62 RGKVPL-LLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+GKV L L + A L Q + +G T LH+AA ++++A +L++
Sbjct: 198 KGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNR 257
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A VD T TPLH+A+ G+ +VK A + TP+H A +GH ++
Sbjct: 258 AAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVV 317
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGV 222
E+L D+ A I +TK+G + +H+A+ H +C +L + V
Sbjct: 318 EMLLDR-AAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNV 358
Score = 85.8 bits (203), Expect = 1e-15
Identities = 56/167 (33%), Positives = 86/167 (51%), Gaps = 3/167 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL +A + N+ V ELL A ++A T +G T +H+AA V++ L+ +GA
Sbjct: 400 GFTPLHIACKK-NRIKVMELLLKHGAS-IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGA 457
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ TN G+T LH+AA G +V+Y A +D+TP+H++A G A I++
Sbjct: 458 SPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQ 517
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L + AS T G T +H+++ GH D A L G L + K
Sbjct: 518 LLQQ-GASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTK 563
Score = 81.8 bits (193), Expect = 2e-14
Identities = 53/158 (33%), Positives = 77/158 (48%), Gaps = 3/158 (1%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL ++ G +V++LL Q A T +G T LHL+AR D+A L+D+GA
Sbjct: 500 QTPLHISARLGKADIVQQLL--QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGAS 557
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
+ T G TPLH+AA G + A+ A TP+H+AA + + LL
Sbjct: 558 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 617
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
D+ AS K+G T +HIA+ D A L + G
Sbjct: 618 LDQ-GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYG 654
Score = 81.0 bits (191), Expect = 4e-14
Identities = 50/173 (28%), Positives = 82/173 (47%), Gaps = 3/173 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D + G PL +A NQ + LL + A G T LH+AA++ +D+A
Sbjct: 592 DAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKN--GYTPLHIAAKKNQMDIATT 649
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L++YGA +A G +H+AA EG +V G AN +++ TP+HLAA+
Sbjct: 650 LLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDR 709
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+ E+L ++ A + +TK G T +H+ G+ L + ++ K
Sbjct: 710 VNVAEVLVNQ-GAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTK 761
Score = 78.6 bits (185), Expect = 2e-13
Identities = 53/152 (34%), Positives = 76/152 (50%), Gaps = 3/152 (1%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++G + LA + G+ MV LL L + +G T LHLAA+ V++A +LV
Sbjct: 660 VTRQGIASVHLAAQEGHVDMVSLLLGRNANVNL--SNKSGLTPLHLAAQEDRVNVAEVLV 717
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
+ GA VDA G TPLH+ G+ +V + A TP+H AA+ GH
Sbjct: 718 NQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTH 777
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGH 210
II +L AS E T +G+T + IA G+
Sbjct: 778 IINVLLQN-NASPNELTVNGNTALGIARRLGY 808
Score = 73.3 bits (172), Expect = 8e-12
Identities = 43/125 (34%), Positives = 70/125 (56%), Gaps = 2/125 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
Q G L LA + G+ +V ELL Q + A T G+TALH+A+ ++ ++LV
Sbjct: 72 QNGLNALHLASKEGHVEVVSELL--QREANVDAATKKGNTALHIASLAGQAEVVKVLVTN 129
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+A + G TPL++AA E +VK+ A+ ++A + TP+ +A + GH ++
Sbjct: 130 GANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVV 189
Query: 181 ELLAD 185
LL +
Sbjct: 190 SLLLE 194
Score = 72.1 bits (169), Expect = 2e-11
Identities = 49/169 (28%), Positives = 80/169 (47%), Gaps = 3/169 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL +A + G + LL Q + A +G T LH+AA + +A +L+D
Sbjct: 563 KKGFTPLHVAAKYGKLEVANLLL--QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 620
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA A G TPLHIAA + + A+A + +HLAA+ GH ++
Sbjct: 621 GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMV 680
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
LL + A++ K G T +H+A+ + A +L +G ++ K
Sbjct: 681 SLLLGR-NANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTK 728
Score = 71.3 bits (167), Expect = 3e-11
Identities = 45/159 (28%), Positives = 74/159 (46%), Gaps = 3/159 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A + + LL + A T G ++HLAA+ VDM +L+
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTLL--EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGR 686
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A V+ +N +G TPLH+AA E + + A+ TP+H+ G+ I+
Sbjct: 687 NANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIV 746
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
L + A + +TK+G T +H A+ GH +L +
Sbjct: 747 NFLL-QHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 784
Score = 67.3 bits (157), Expect = 6e-10
Identities = 45/159 (28%), Positives = 73/159 (45%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL +G++ +V LL A + + T G + LH+A + ++ ++L+ +
Sbjct: 301 GLTPLHCGARSGHEQVVEMLLDR--AAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNV 358
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VD T LH+AA G + K +AN TP+H+A + ++EL
Sbjct: 359 PVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMEL 418
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L K ASI T+ G T +H+A+ GH + L G
Sbjct: 419 LL-KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHG 456
Score = 56.0 bits (129), Expect = 1e-06
Identities = 48/169 (28%), Positives = 76/169 (44%), Gaps = 3/169 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A + + + V+ LL Q + T TALH+AA +A++L+D
Sbjct: 332 KNGLSPLHMATQGDHLNCVQLLL--QHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDK 389
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A +A G TPLHIA + +++ A+ TP+H+AA GH I+
Sbjct: 390 KANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIV 449
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L AS G T +H+A+ +G A+ L + G + K
Sbjct: 450 SQLM-HHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAK 497
Score = 49.2 bits (112), Expect = 2e-04
Identities = 29/117 (24%), Positives = 56/117 (47%), Gaps = 1/117 (0%)
Query: 105 AARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED 164
AAR ++ A + G ++ N G LH+A+ EG +V AN A +
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 165 RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
T +H+A+ G A ++++L A++ ++++G T +++A+ H + L G
Sbjct: 108 NTALHIASLAGQAEVVKVLVTN-GANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNG 163
Score = 46.4 bits (105), Expect = 0.001
Identities = 33/121 (27%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL LA + + V E+L Q A + A T G T LH+ ++ + L+ + A
Sbjct: 697 GLTPLHLAAQEDRVN-VAEVLVNQGAH-VDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSA 754
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+A G TPLH AA +G ++ A+ T + +A G+ ++++
Sbjct: 755 KVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDT 814
Query: 183 L 183
L
Sbjct: 815 L 815
>AL592430-3|CAI40518.1| 4372|Homo sapiens ankyrin 3, node of Ranvier
(ankyrin G) protein.
Length = 4372
Score = 313 bits (769), Expect = 4e-84
Identities = 229/752 (30%), Positives = 373/752 (49%), Gaps = 42/752 (5%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H A++ GHV +++ LLQ+ +VD T TALHIA + + VV+ L+ GA+
Sbjct: 73 NGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGAN 132
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V+ + + TPL++AA+ + + LL +GA + ATEDG TP+ VA + G+ +
Sbjct: 133 VNAQS-QNGFTPLYMAAQ-ENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVS 190
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDI---VRHLIEFVKDHKGESVSTA 838
LLLE+ D K ++ + + + A D V F H
Sbjct: 191 LLLEN--DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNI 248
Query: 839 FIDAVDEDGASALHYACK--VTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHY 896
+ + + A+A+ + + +T V + +VK L++ GA + +TR T H
Sbjct: 249 NVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGL-TPLHC 307
Query: 897 CAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVD 956
A +G+ V+ EM+ + +S+ N G +PL +A H+ V LL ++ VD
Sbjct: 308 GARSGHEQVV-EMLLDRAAPILSKTKN-----GLSPLHMATQGDHLNCVQLLLQHNVPVD 361
Query: 957 VFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIR 1016
+ +ALH+AA G+ +V LL KA N+KA NG T LH+A +++ L++
Sbjct: 362 DVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLK 421
Query: 1017 DHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSE 1076
H A I +T TP+H+AA G + + L+ GA+ + T+ G+ +H AA++ +E
Sbjct: 422 -HGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAE 480
Query: 1077 VVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPL 1136
VV+ +L Q V A KD T HI+A G ++++L++ G + TPL
Sbjct: 481 VVR-YLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQ---QGASPNAATTSGYTPL 536
Query: 1137 QLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
L+A GH DV L+ GAS + + G T +H+AA++G V +++ + ++ K
Sbjct: 537 HLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGK 596
Query: 1197 LGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGN 1256
GLTPLH+AA+Y + LL G S P A++G TPLH+AA
Sbjct: 597 SGLTPLHVAAHYDNQKVALLLLDQ-----------GAS--PHAAAKNGYTPLHIAAKKNQ 643
Query: 1257 ENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTG 1316
++ LL G A+A + + G +HLA GH+ +V LLL R+A + G T
Sbjct: 644 MDIATTLLEY-GADANAVTRQ-GIASVHLAAQEGHVDMVSLLLGRNANV------SGLTP 695
Query: 1317 LHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSET 1376
LH+A+ + EVL+ QGA ++A K G+TPLH G++ +V L + A ++T
Sbjct: 696 LHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKT 755
Query: 1377 NLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
P+ AA + H ++ LL L
Sbjct: 756 KNGYTPLHQAAQQGHTHIINVLLQNNASPNEL 787
Score = 284 bits (697), Expect = 2e-75
Identities = 227/764 (29%), Positives = 362/764 (47%), Gaps = 72/764 (9%)
Query: 656 EKYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETL 715
++ K D S AAR GH+ ++ G +++ + ALH+A + VV L
Sbjct: 34 DRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSEL 93
Query: 716 LGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
L A+V K+ T LHIA+ + + +L+ +GA N +++G TP+++AA+
Sbjct: 94 LQREANVD-AATKKGNTALHIAS-LAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQEN 151
Query: 776 NLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESV 835
+L + LL++G T+ G TPL +A + +V L+E D KG+
Sbjct: 152 HLEVVKFLLDNGASQSLATE-------DGFTPLAVALQQGHDQVVSLLLE--NDTKGKV- 201
Query: 836 STAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFH 895
ALH A + K++ K L++N + ++++ T H
Sbjct: 202 -----------RLPALHIAAR--KDDTK-------AAALLLQNDNNADVESKSGF-TPLH 240
Query: 896 YCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARV 955
A GN +V T ++ + D +N I TPL +A RG+ +V LL A++
Sbjct: 241 IAAHYGNINVATLLLNRAAAVD----FTARNDI--TPLHVASKRGNANMVKLLLDRGAKI 294
Query: 956 DVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLI 1015
D +G + LH A G+ QV + LL A I SK +NG + LH+A + + V+ L+
Sbjct: 295 DAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLL 354
Query: 1016 RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYS 1075
+ HN +D +T T LH+AA G +V K+LL+ AN +A G P+H A + N
Sbjct: 355 Q-HNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRI 413
Query: 1076 EVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTP 1135
+V++L L +H + A T+ G T H+AA G V ++ +LM G + T
Sbjct: 414 KVMELLL-KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLM---HHGASPNTTNVRGETA 469
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK 1195
L +AA G A+VVR LV+ GA + + T +H++A G +++ + ++
Sbjct: 470 LHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAAT 529
Query: 1196 KLGLTPLHIAAYYGQAETVRELLSHVPG----TVKSEAPTGV----------------SL 1235
G TPLH++A G + LL H T K P V S
Sbjct: 530 TSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSA 589
Query: 1236 VPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIV 1295
P +SGLTPLH+AA+ N+ V LLL+ G AA+ +NGY PLH+A M I
Sbjct: 590 SPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ-GASPHAAA-KNGYTPLHIAAKKNQMDIA 647
Query: 1296 GLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAK 1355
LL A+ ++ R G +H+A+ GH MV +LLG+ A + +G TPLH AA+
Sbjct: 648 TTLLEYGAD-ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV-----SGLTPLHLAAQ 701
Query: 1356 AGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+NV ++L GA ++T + P+ + ++ +LL
Sbjct: 702 EDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLL 745
Score = 270 bits (662), Expect = 4e-71
Identities = 220/720 (30%), Positives = 350/720 (48%), Gaps = 64/720 (8%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++ AA+ H+ ++ LL G S + T D +T L +A++ VV LL
Sbjct: 139 NGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTK 198
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
GK R LHIAAR D K A +LL++ + ++ G TP+H+AA +GN+
Sbjct: 199 -----GKVRLPALHIAAR-KDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVAT 252
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LLL + + TPL +A + ++V+ L++ +G A ID
Sbjct: 253 LLLN-------RAAAVDFTARNDITPLHVASKRGNANMVKLLLD-----RG-----AKID 295
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
A DG + LH + E QVV+ L++ A + +T+ N + H
Sbjct: 296 AKTRDGLTPLHCGARSGHE---------QVVEMLLDRAAPILSKTK-NGLSPLHMATQGD 345
Query: 902 NNDVMTEMIAH-ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDV 960
+ + + ++ H + DV+ T L +A H GH ++ LL A + +
Sbjct: 346 HLNCVQLLLQHNVPVDDVTNDY-------LTALHVAAHCGHYKVAKVLLDKKANPNAKAL 398
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
G + LH+A + ++V + LL + A I + +G T +H+AA G+ ++V L+ H A
Sbjct: 399 NGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH-HGA 457
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQL 1080
+ ++ +T LH+AA SGQ EV + L++ GA ++A + Q P+H +A+ +++VQ
Sbjct: 458 SPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQ 517
Query: 1081 FLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAA 1140
LQQ + ATT G T H++A +G V L+ D +S K TPL +AA
Sbjct: 518 LLQQGASPNAATTS-GYTPLHLSAREGHEDVAAFLL--DHGASLSITTK-KGFTPLHVAA 573
Query: 1141 EGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLT 1200
+ G +V +L++ AS ++GLT +H+AA + + V ++ ++ K G T
Sbjct: 574 KYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYT 633
Query: 1201 PLHIAAYYGQAETVRELLSHVP----------GTVKSEAPTG-VSLVPVLGAE----SGL 1245
PLHIAA Q + LL + +V A G V +V +L SGL
Sbjct: 634 PLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVSGL 693
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
TPLHLAA NV +L+N G DA + + GY PLH+ C G++ IV LL SA++
Sbjct: 694 TPLHLAAQEDRVNVAEVLVNQ-GAHVDAQT-KMGYTPLHVGCHYGNIKIVNFLLQHSAKV 751
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
T ++G T LH A+ GH ++ VLL A N NG T L A + G+++VV L
Sbjct: 752 NAKT-KNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 810
Score = 256 bits (627), Expect = 6e-67
Identities = 211/692 (30%), Positives = 331/692 (47%), Gaps = 66/692 (9%)
Query: 737 AARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKV 796
AAR +K AL +K+G N ++G+ +H+A+K G++ + LL+ + TK
Sbjct: 48 AARAGHLEK-ALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATK- 105
Query: 797 CIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACK 856
G T L +A + ++V+ L+ + A ++A ++G + L+ A +
Sbjct: 106 ------KGNTALHIASLAGQAEVVKVLV----------TNGANVNAQSQNGFTPLYMAAQ 149
Query: 857 VTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTA 916
EV VK L++NGA SL T T G++ V++ ++ +
Sbjct: 150 ENHLEV---------VKFLLDNGASQSLATEDGF-TPLAVALQQGHDQVVSLLLEN---- 195
Query: 917 DVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQ 976
+ + + L IA + + LL N DV G + LH+AA +G +
Sbjct: 196 ------DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNIN 249
Query: 977 VCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLA 1036
V LL A ++ ARN T LH+A+ G A++VK L+ D A ID T TPLH
Sbjct: 250 VATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLL-DRGAKIDAKTRDGLTPLHCG 308
Query: 1037 AASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDG 1096
A SG +V ++LL+ A I + + G P+H A Q ++ VQL LQ H V T D
Sbjct: 309 ARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ-HNVPVDDVTNDY 367
Query: 1097 NTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGA 1156
T H+AA G KV + L+ D+ +A+ LN TPL +A + V+ +L++ GA
Sbjct: 368 LTALHVAAHCGHYKVAKVLL--DKKANPNAK-ALNGFTPLHIACKKNRIKVMELLLKHGA 424
Query: 1157 SCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRE 1216
S +GLT +H+AA GH N++ + ++ G T LH+AA GQAE VR
Sbjct: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484
Query: 1217 LL---SHVPGTVKSE-APTGVSL----------------VPVLGAESGLTPLHLAAYNGN 1256
L+ + V K + P +S P SG TPLHL+A G+
Sbjct: 485 LVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGH 544
Query: 1257 ENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTG 1316
E+V LL+ + + + + G+ PLH+A G + + LLL +SA + + G T
Sbjct: 545 EDVAAFLLDHGA--SLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP-DAAGKSGLTP 601
Query: 1317 LHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSET 1376
LH+A+ + + ++ +LL QGA +A KNG+TPLH AAK +++ L E GA + T
Sbjct: 602 LHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVT 661
Query: 1377 NLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
A + AA E H D++ LL + + L
Sbjct: 662 RQGIASVHLAAQEGHVDMVSLLLGRNANVSGL 693
Score = 247 bits (605), Expect = 3e-64
Identities = 176/546 (32%), Positives = 279/546 (51%), Gaps = 37/546 (6%)
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
+N N G L +A GH+++V+ LL A VD +G +ALH+A+ G +V L
Sbjct: 67 INICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVL 126
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
+TN A +N++++NG T L++AA + +VKFL+ D+ A + T TPL +A G
Sbjct: 127 VTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLL-DNGASQSLATEDGFTPLAVALQQGH 185
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAH 1101
+V LLLE D ++ +H AA+ + ++ L LQ N + + K G T H
Sbjct: 186 DQVVSLLLEN----DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVES-KSGFTPLH 240
Query: 1102 IAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDE 1161
IAA G++ V L+ +ARN D TPL +A++ G+A++V++L+ GA +
Sbjct: 241 IAAHYGNINVATLLLNRAAAVDFTARN---DITPLHVASKRGNANMVKLLLDRGAKIDAK 297
Query: 1162 NRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSH- 1220
R GLT +H A GH V++++ +S K GL+PLH+A V+ LL H
Sbjct: 298 TRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHN 357
Query: 1221 VP-GTVKSEAPTGVSLVPVLG------------------AESGLTPLHLAAYNGNENVVR 1261
VP V ++ T + + G A +G TPLH+A V+
Sbjct: 358 VPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVME 417
Query: 1262 LLL-NSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIA 1320
LLL + A +QA E+G P+H+A F GH++IV L+ A ++T+ G+T LH+A
Sbjct: 418 LLLKHGASIQA---VTESGLTPIHVAAFMGHVNIVSQLMHHGASP-NTTNVRGETALHMA 473
Query: 1321 STHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNC 1380
+ G ++V L+ GA++ A K+ TPLH +A+ G ++V+ L + GASP + T
Sbjct: 474 ARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGY 533
Query: 1381 APIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAP 1440
P+ +A E H DV +LL +H + K+ L V +K + + + +L A
Sbjct: 534 TPLHLSAREGHEDVAAFLL--DHGASLSITTKKGFTPLHVAAK-YGKLEVANLLLQKSAS 590
Query: 1441 VDTAAK 1446
D A K
Sbjct: 591 PDAAGK 596
Score = 206 bits (502), Expect = 9e-52
Identities = 156/524 (29%), Positives = 256/524 (48%), Gaps = 45/524 (8%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G +H A + H+ + LLQ VD TND TALH+A V + LL A+
Sbjct: 333 NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN 392
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ + TPLHIA + + K +LLK GA TE G+TP+HVAA G++ +
Sbjct: 393 PNAKA-LNGFTPLHIACK-KNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVS 450
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
L+ G P V GET L MA RS ++VR+L++ A ++
Sbjct: 451 QLMHHGASPNTTN-------VRGETALHMAARSGQAEVVRYLVQ----------DGAQVE 493
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
A +D + LH + ++ K ++ V+ L++ GA + T + T H A G
Sbjct: 494 AKAKDDQTPLHISARLGKADI---------VQQLLQQGASPNAATTSGY-TPLHLSAREG 543
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ DV ++ H ++ ++ G+TPL +A G +++ N LL A D
Sbjct: 544 HEDVAAFLLDHGASLSIT------TKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKS 597
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM 1021
G + LH+AA + +V LL A ++ A+NG T LH+AA + L+ ++ A
Sbjct: 598 GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLL-EYGAD 656
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
+ +T + +HLAA G +++ LLL AN+ G P+H AAQ + V ++
Sbjct: 657 ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVS-----GLTPLHLAAQEDRVNVAEVL 711
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
+ Q + V A TK G T H+ G++K++ L++ + ++A+ K N TPL AA+
Sbjct: 712 VNQGAH-VDAQTKMGYTPLHVGCHYGNIKIVNFLLQ--HSAKVNAKTK-NGYTPLHQAAQ 767
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMR 1185
GH ++ VL++ AS + G TA+ +A G+ +V+D ++
Sbjct: 768 QGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLK 811
Score = 149 bits (362), Expect = 8e-35
Identities = 127/458 (27%), Positives = 209/458 (45%), Gaps = 44/458 (9%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K +G +H A + + ++ LL+ G S+ T T +H+A +V L+ +
Sbjct: 396 KALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHH 455
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
GA + + ET LH+AAR + L++ GA +D TP+H++A+ G
Sbjct: 456 GASPNTT-NVRGETALHMAARSGQAE-VVRYLVQDGAQVEAKAKDDQTPLHISARLGKAD 513
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LL+ G P T +G TPL ++ R D+ F+ DH G S+S
Sbjct: 514 IVQQLLQQGASPNAAT-------TSGYTPLHLSAREGHEDVA----AFLLDH-GASLS-- 559
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVS-LQTRHNHETAFHYC 897
+ G + LH A K K EV A+ + K + A S L H A HY
Sbjct: 560 ---ITTKKGFTPLHVAAKYGKLEV----ANLLLQKSASPDAAGKSGLTPLH---VAAHY- 608
Query: 898 AIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
+N + ++ + + A N G+TPL IA + M + TLL A +
Sbjct: 609 ----DNQKVALLLLDQGASPHAAAKN-----GYTPLHIAAKKNQMDIATTLLEYGADANA 659
Query: 958 FDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRD 1017
+G +++HLAA+ G++ + LL A + +G T LHLAA ++ + L+ +
Sbjct: 660 VTRQGIASVHLAAQEGHVDMVSLLLGRNANV-----SGLTPLHLAAQEDRVNVAEVLV-N 713
Query: 1018 HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEV 1077
A +D T TPLH+ G I++ LL+ A ++A + G P+H AAQ ++ +
Sbjct: 714 QGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHI 773
Query: 1078 VQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEEL 1115
+ + LQ + + T +GNT IA G + V++ L
Sbjct: 774 INVLLQNNAS-PNELTVNGNTALGIARRLGYISVVDTL 810
Score = 87.0 bits (206), Expect = 6e-16
Identities = 55/162 (33%), Positives = 83/162 (51%), Gaps = 3/162 (1%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V + G P+ +A G+ ++V +L+ + T G+TALH+AAR ++ R LV
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPN--TTNVRGETALHMAARSGQAEVVRYLV 486
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
GA V+A QTPLHI+A G +V+ A+ A TP+HL+A GH
Sbjct: 487 QDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHED 546
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+ L D AS+ TK G T +H+A+ G + A +L +K
Sbjct: 547 VAAFLLD-HGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK 587
Score = 85.8 bits (203), Expect = 1e-15
Identities = 49/162 (30%), Positives = 81/162 (50%), Gaps = 2/162 (1%)
Query: 62 RGKVPL-LLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+GKV L L + A L Q + +G T LH+AA ++++A +L++
Sbjct: 198 KGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNR 257
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A VD T TPLH+A+ G+ +VK A + TP+H A +GH ++
Sbjct: 258 AAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVV 317
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGV 222
E+L D+ A I +TK+G + +H+A+ H +C +L + V
Sbjct: 318 EMLLDR-AAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNV 358
Score = 85.8 bits (203), Expect = 1e-15
Identities = 56/167 (33%), Positives = 86/167 (51%), Gaps = 3/167 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL +A + N+ V ELL A ++A T +G T +H+AA V++ L+ +GA
Sbjct: 400 GFTPLHIACKK-NRIKVMELLLKHGAS-IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGA 457
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ TN G+T LH+AA G +V+Y A +D+TP+H++A G A I++
Sbjct: 458 SPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQ 517
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L + AS T G T +H+++ GH D A L G L + K
Sbjct: 518 LLQQ-GASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTK 563
Score = 81.8 bits (193), Expect = 2e-14
Identities = 53/158 (33%), Positives = 77/158 (48%), Gaps = 3/158 (1%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL ++ G +V++LL Q A T +G T LHL+AR D+A L+D+GA
Sbjct: 500 QTPLHISARLGKADIVQQLL--QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGAS 557
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
+ T G TPLH+AA G + A+ A TP+H+AA + + LL
Sbjct: 558 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 617
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
D+ AS K+G T +HIA+ D A L + G
Sbjct: 618 LDQ-GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYG 654
Score = 74.1 bits (174), Expect = 5e-12
Identities = 52/152 (34%), Positives = 75/152 (49%), Gaps = 8/152 (5%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++G + LA + G+ MV LL + +G T LHLAA+ V++A +LV
Sbjct: 660 VTRQGIASVHLAAQEGHVDMVSLLLG-------RNANVSGLTPLHLAAQEDRVNVAEVLV 712
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
+ GA VDA G TPLH+ G+ +V + A TP+H AA+ GH
Sbjct: 713 NQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTH 772
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGH 210
II +L AS E T +G+T + IA G+
Sbjct: 773 IINVLLQN-NASPNELTVNGNTALGIARRLGY 803
Score = 73.3 bits (172), Expect = 8e-12
Identities = 43/125 (34%), Positives = 70/125 (56%), Gaps = 2/125 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
Q G L LA + G+ +V ELL Q + A T G+TALH+A+ ++ ++LV
Sbjct: 72 QNGLNALHLASKEGHVEVVSELL--QREANVDAATKKGNTALHIASLAGQAEVVKVLVTN 129
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+A + G TPL++AA E +VK+ A+ ++A + TP+ +A + GH ++
Sbjct: 130 GANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVV 189
Query: 181 ELLAD 185
LL +
Sbjct: 190 SLLLE 194
Score = 67.3 bits (157), Expect = 6e-10
Identities = 45/159 (28%), Positives = 73/159 (45%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL +G++ +V LL A + + T G + LH+A + ++ ++L+ +
Sbjct: 301 GLTPLHCGARSGHEQVVEMLLDR--AAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNV 358
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VD T LH+AA G + K +AN TP+H+A + ++EL
Sbjct: 359 PVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMEL 418
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L K ASI T+ G T +H+A+ GH + L G
Sbjct: 419 LL-KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHG 456
Score = 65.3 bits (152), Expect = 2e-09
Identities = 48/169 (28%), Positives = 79/169 (46%), Gaps = 8/169 (4%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL +A + G + LL Q + A +G T LH+AA + +A +L+D
Sbjct: 563 KKGFTPLHVAAKYGKLEVANLLL--QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 620
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA A G TPLHIAA + + A+A + +HLAA+ GH ++
Sbjct: 621 GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMV 680
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
LL + A++ G T +H+A+ + A +L +G ++ K
Sbjct: 681 SLLLGR-NANV-----SGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTK 723
Score = 62.5 bits (145), Expect = 2e-08
Identities = 44/159 (27%), Positives = 71/159 (44%), Gaps = 8/159 (5%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A + + LL + A T G ++HLAA+ VDM +L+
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTLL--EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGR 686
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A N +G TPLH+AA E + + A+ TP+H+ G+ I+
Sbjct: 687 NA-----NVSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIV 741
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
L + A + +TK+G T +H A+ GH +L +
Sbjct: 742 NFLL-QHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 779
Score = 56.0 bits (129), Expect = 1e-06
Identities = 48/169 (28%), Positives = 76/169 (44%), Gaps = 3/169 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A + + + V+ LL Q + T TALH+AA +A++L+D
Sbjct: 332 KNGLSPLHMATQGDHLNCVQLLL--QHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDK 389
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A +A G TPLHIA + +++ A+ TP+H+AA GH I+
Sbjct: 390 KANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIV 449
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L AS G T +H+A+ +G A+ L + G + K
Sbjct: 450 SQLM-HHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAK 497
Score = 49.2 bits (112), Expect = 2e-04
Identities = 29/117 (24%), Positives = 56/117 (47%), Gaps = 1/117 (0%)
Query: 105 AARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED 164
AAR ++ A + G ++ N G LH+A+ EG +V AN A +
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 165 RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
T +H+A+ G A ++++L A++ ++++G T +++A+ H + L G
Sbjct: 108 NTALHIASLAGQAEVVKVLVTN-GANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNG 163
Score = 46.4 bits (105), Expect = 0.001
Identities = 33/121 (27%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL LA + + V E+L Q A + A T G T LH+ ++ + L+ + A
Sbjct: 692 GLTPLHLAAQEDRVN-VAEVLVNQGAH-VDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSA 749
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+A G TPLH AA +G ++ A+ T + +A G+ ++++
Sbjct: 750 KVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDT 809
Query: 183 L 183
L
Sbjct: 810 L 810
>AL359377-2|CAI41373.1| 4372|Homo sapiens ankyrin 3, node of Ranvier
(ankyrin G) protein.
Length = 4372
Score = 313 bits (769), Expect = 4e-84
Identities = 229/752 (30%), Positives = 373/752 (49%), Gaps = 42/752 (5%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H A++ GHV +++ LLQ+ +VD T TALHIA + + VV+ L+ GA+
Sbjct: 73 NGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGAN 132
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V+ + + TPL++AA+ + + LL +GA + ATEDG TP+ VA + G+ +
Sbjct: 133 VNAQS-QNGFTPLYMAAQ-ENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVS 190
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDI---VRHLIEFVKDHKGESVSTA 838
LLLE+ D K ++ + + + A D V F H
Sbjct: 191 LLLEN--DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNI 248
Query: 839 FIDAVDEDGASALHYACK--VTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHY 896
+ + + A+A+ + + +T V + +VK L++ GA + +TR T H
Sbjct: 249 NVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGL-TPLHC 307
Query: 897 CAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVD 956
A +G+ V+ EM+ + +S+ N G +PL +A H+ V LL ++ VD
Sbjct: 308 GARSGHEQVV-EMLLDRAAPILSKTKN-----GLSPLHMATQGDHLNCVQLLLQHNVPVD 361
Query: 957 VFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIR 1016
+ +ALH+AA G+ +V LL KA N+KA NG T LH+A +++ L++
Sbjct: 362 DVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLK 421
Query: 1017 DHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSE 1076
H A I +T TP+H+AA G + + L+ GA+ + T+ G+ +H AA++ +E
Sbjct: 422 -HGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAE 480
Query: 1077 VVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPL 1136
VV+ +L Q V A KD T HI+A G ++++L++ G + TPL
Sbjct: 481 VVR-YLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQ---QGASPNAATTSGYTPL 536
Query: 1137 QLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
L+A GH DV L+ GAS + + G T +H+AA++G V +++ + ++ K
Sbjct: 537 HLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGK 596
Query: 1197 LGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGN 1256
GLTPLH+AA+Y + LL G S P A++G TPLH+AA
Sbjct: 597 SGLTPLHVAAHYDNQKVALLLLDQ-----------GAS--PHAAAKNGYTPLHIAAKKNQ 643
Query: 1257 ENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTG 1316
++ LL G A+A + + G +HLA GH+ +V LLL R+A + G T
Sbjct: 644 MDIATTLLEY-GADANAVTRQ-GIASVHLAAQEGHVDMVSLLLGRNANV------SGLTP 695
Query: 1317 LHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSET 1376
LH+A+ + EVL+ QGA ++A K G+TPLH G++ +V L + A ++T
Sbjct: 696 LHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKT 755
Query: 1377 NLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
P+ AA + H ++ LL L
Sbjct: 756 KNGYTPLHQAAQQGHTHIINVLLQNNASPNEL 787
Score = 284 bits (697), Expect = 2e-75
Identities = 227/764 (29%), Positives = 362/764 (47%), Gaps = 72/764 (9%)
Query: 656 EKYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETL 715
++ K D S AAR GH+ ++ G +++ + ALH+A + VV L
Sbjct: 34 DRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSEL 93
Query: 716 LGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
L A+V K+ T LHIA+ + + +L+ +GA N +++G TP+++AA+
Sbjct: 94 LQREANVD-AATKKGNTALHIAS-LAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQEN 151
Query: 776 NLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESV 835
+L + LL++G T+ G TPL +A + +V L+E D KG+
Sbjct: 152 HLEVVKFLLDNGASQSLATE-------DGFTPLAVALQQGHDQVVSLLLE--NDTKGKV- 201
Query: 836 STAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFH 895
ALH A + K++ K L++N + ++++ T H
Sbjct: 202 -----------RLPALHIAAR--KDDTK-------AAALLLQNDNNADVESKSGF-TPLH 240
Query: 896 YCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARV 955
A GN +V T ++ + D +N I TPL +A RG+ +V LL A++
Sbjct: 241 IAAHYGNINVATLLLNRAAAVD----FTARNDI--TPLHVASKRGNANMVKLLLDRGAKI 294
Query: 956 DVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLI 1015
D +G + LH A G+ QV + LL A I SK +NG + LH+A + + V+ L+
Sbjct: 295 DAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLL 354
Query: 1016 RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYS 1075
+ HN +D +T T LH+AA G +V K+LL+ AN +A G P+H A + N
Sbjct: 355 Q-HNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRI 413
Query: 1076 EVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTP 1135
+V++L L +H + A T+ G T H+AA G V ++ +LM G + T
Sbjct: 414 KVMELLL-KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLM---HHGASPNTTNVRGETA 469
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK 1195
L +AA G A+VVR LV+ GA + + T +H++A G +++ + ++
Sbjct: 470 LHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAAT 529
Query: 1196 KLGLTPLHIAAYYGQAETVRELLSHVPG----TVKSEAPTGV----------------SL 1235
G TPLH++A G + LL H T K P V S
Sbjct: 530 TSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSA 589
Query: 1236 VPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIV 1295
P +SGLTPLH+AA+ N+ V LLL+ G AA+ +NGY PLH+A M I
Sbjct: 590 SPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ-GASPHAAA-KNGYTPLHIAAKKNQMDIA 647
Query: 1296 GLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAK 1355
LL A+ ++ R G +H+A+ GH MV +LLG+ A + +G TPLH AA+
Sbjct: 648 TTLLEYGAD-ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV-----SGLTPLHLAAQ 701
Query: 1356 AGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+NV ++L GA ++T + P+ + ++ +LL
Sbjct: 702 EDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLL 745
Score = 270 bits (662), Expect = 4e-71
Identities = 220/720 (30%), Positives = 350/720 (48%), Gaps = 64/720 (8%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++ AA+ H+ ++ LL G S + T D +T L +A++ VV LL
Sbjct: 139 NGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTK 198
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
GK R LHIAAR D K A +LL++ + ++ G TP+H+AA +GN+
Sbjct: 199 -----GKVRLPALHIAAR-KDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVAT 252
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LLL + + TPL +A + ++V+ L++ +G A ID
Sbjct: 253 LLLN-------RAAAVDFTARNDITPLHVASKRGNANMVKLLLD-----RG-----AKID 295
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
A DG + LH + E QVV+ L++ A + +T+ N + H
Sbjct: 296 AKTRDGLTPLHCGARSGHE---------QVVEMLLDRAAPILSKTK-NGLSPLHMATQGD 345
Query: 902 NNDVMTEMIAH-ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDV 960
+ + + ++ H + DV+ T L +A H GH ++ LL A + +
Sbjct: 346 HLNCVQLLLQHNVPVDDVTNDY-------LTALHVAAHCGHYKVAKVLLDKKANPNAKAL 398
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
G + LH+A + ++V + LL + A I + +G T +H+AA G+ ++V L+ H A
Sbjct: 399 NGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH-HGA 457
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQL 1080
+ ++ +T LH+AA SGQ EV + L++ GA ++A + Q P+H +A+ +++VQ
Sbjct: 458 SPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQ 517
Query: 1081 FLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAA 1140
LQQ + ATT G T H++A +G V L+ D +S K TPL +AA
Sbjct: 518 LLQQGASPNAATTS-GYTPLHLSAREGHEDVAAFLL--DHGASLSITTK-KGFTPLHVAA 573
Query: 1141 EGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLT 1200
+ G +V +L++ AS ++GLT +H+AA + + V ++ ++ K G T
Sbjct: 574 KYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYT 633
Query: 1201 PLHIAAYYGQAETVRELLSHVP----------GTVKSEAPTG-VSLVPVLGAE----SGL 1245
PLHIAA Q + LL + +V A G V +V +L SGL
Sbjct: 634 PLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVSGL 693
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
TPLHLAA NV +L+N G DA + + GY PLH+ C G++ IV LL SA++
Sbjct: 694 TPLHLAAQEDRVNVAEVLVNQ-GAHVDAQT-KMGYTPLHVGCHYGNIKIVNFLLQHSAKV 751
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
T ++G T LH A+ GH ++ VLL A N NG T L A + G+++VV L
Sbjct: 752 NAKT-KNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 810
Score = 256 bits (627), Expect = 6e-67
Identities = 211/692 (30%), Positives = 331/692 (47%), Gaps = 66/692 (9%)
Query: 737 AARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKV 796
AAR +K AL +K+G N ++G+ +H+A+K G++ + LL+ + TK
Sbjct: 48 AARAGHLEK-ALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATK- 105
Query: 797 CIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACK 856
G T L +A + ++V+ L+ + A ++A ++G + L+ A +
Sbjct: 106 ------KGNTALHIASLAGQAEVVKVLV----------TNGANVNAQSQNGFTPLYMAAQ 149
Query: 857 VTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTA 916
EV VK L++NGA SL T T G++ V++ ++ +
Sbjct: 150 ENHLEV---------VKFLLDNGASQSLATEDGF-TPLAVALQQGHDQVVSLLLEN---- 195
Query: 917 DVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQ 976
+ + + L IA + + LL N DV G + LH+AA +G +
Sbjct: 196 ------DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNIN 249
Query: 977 VCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLA 1036
V LL A ++ ARN T LH+A+ G A++VK L+ D A ID T TPLH
Sbjct: 250 VATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLL-DRGAKIDAKTRDGLTPLHCG 308
Query: 1037 AASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDG 1096
A SG +V ++LL+ A I + + G P+H A Q ++ VQL LQ H V T D
Sbjct: 309 ARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ-HNVPVDDVTNDY 367
Query: 1097 NTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGA 1156
T H+AA G KV + L+ D+ +A+ LN TPL +A + V+ +L++ GA
Sbjct: 368 LTALHVAAHCGHYKVAKVLL--DKKANPNAK-ALNGFTPLHIACKKNRIKVMELLLKHGA 424
Query: 1157 SCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRE 1216
S +GLT +H+AA GH N++ + ++ G T LH+AA GQAE VR
Sbjct: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484
Query: 1217 LL---SHVPGTVKSE-APTGVSL----------------VPVLGAESGLTPLHLAAYNGN 1256
L+ + V K + P +S P SG TPLHL+A G+
Sbjct: 485 LVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGH 544
Query: 1257 ENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTG 1316
E+V LL+ + + + + G+ PLH+A G + + LLL +SA + + G T
Sbjct: 545 EDVAAFLLDHGA--SLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP-DAAGKSGLTP 601
Query: 1317 LHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSET 1376
LH+A+ + + ++ +LL QGA +A KNG+TPLH AAK +++ L E GA + T
Sbjct: 602 LHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVT 661
Query: 1377 NLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
A + AA E H D++ LL + + L
Sbjct: 662 RQGIASVHLAAQEGHVDMVSLLLGRNANVSGL 693
Score = 247 bits (605), Expect = 3e-64
Identities = 176/546 (32%), Positives = 279/546 (51%), Gaps = 37/546 (6%)
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
+N N G L +A GH+++V+ LL A VD +G +ALH+A+ G +V L
Sbjct: 67 INICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVL 126
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
+TN A +N++++NG T L++AA + +VKFL+ D+ A + T TPL +A G
Sbjct: 127 VTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLL-DNGASQSLATEDGFTPLAVALQQGH 185
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAH 1101
+V LLLE D ++ +H AA+ + ++ L LQ N + + K G T H
Sbjct: 186 DQVVSLLLEN----DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVES-KSGFTPLH 240
Query: 1102 IAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDE 1161
IAA G++ V L+ +ARN D TPL +A++ G+A++V++L+ GA +
Sbjct: 241 IAAHYGNINVATLLLNRAAAVDFTARN---DITPLHVASKRGNANMVKLLLDRGAKIDAK 297
Query: 1162 NRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSH- 1220
R GLT +H A GH V++++ +S K GL+PLH+A V+ LL H
Sbjct: 298 TRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHN 357
Query: 1221 VP-GTVKSEAPTGVSLVPVLG------------------AESGLTPLHLAAYNGNENVVR 1261
VP V ++ T + + G A +G TPLH+A V+
Sbjct: 358 VPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVME 417
Query: 1262 LLL-NSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIA 1320
LLL + A +QA E+G P+H+A F GH++IV L+ A ++T+ G+T LH+A
Sbjct: 418 LLLKHGASIQA---VTESGLTPIHVAAFMGHVNIVSQLMHHGASP-NTTNVRGETALHMA 473
Query: 1321 STHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNC 1380
+ G ++V L+ GA++ A K+ TPLH +A+ G ++V+ L + GASP + T
Sbjct: 474 ARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGY 533
Query: 1381 APIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAP 1440
P+ +A E H DV +LL +H + K+ L V +K + + + +L A
Sbjct: 534 TPLHLSAREGHEDVAAFLL--DHGASLSITTKKGFTPLHVAAK-YGKLEVANLLLQKSAS 590
Query: 1441 VDTAAK 1446
D A K
Sbjct: 591 PDAAGK 596
Score = 206 bits (502), Expect = 9e-52
Identities = 156/524 (29%), Positives = 256/524 (48%), Gaps = 45/524 (8%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G +H A + H+ + LLQ VD TND TALH+A V + LL A+
Sbjct: 333 NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN 392
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ + TPLHIA + + K +LLK GA TE G+TP+HVAA G++ +
Sbjct: 393 PNAKA-LNGFTPLHIACK-KNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVS 450
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
L+ G P V GET L MA RS ++VR+L++ A ++
Sbjct: 451 QLMHHGASPNTTN-------VRGETALHMAARSGQAEVVRYLVQ----------DGAQVE 493
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
A +D + LH + ++ K ++ V+ L++ GA + T + T H A G
Sbjct: 494 AKAKDDQTPLHISARLGKADI---------VQQLLQQGASPNAATTSGY-TPLHLSAREG 543
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ DV ++ H ++ ++ G+TPL +A G +++ N LL A D
Sbjct: 544 HEDVAAFLLDHGASLSIT------TKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKS 597
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM 1021
G + LH+AA + +V LL A ++ A+NG T LH+AA + L+ ++ A
Sbjct: 598 GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLL-EYGAD 656
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
+ +T + +HLAA G +++ LLL AN+ G P+H AAQ + V ++
Sbjct: 657 ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVS-----GLTPLHLAAQEDRVNVAEVL 711
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
+ Q + V A TK G T H+ G++K++ L++ + ++A+ K N TPL AA+
Sbjct: 712 VNQGAH-VDAQTKMGYTPLHVGCHYGNIKIVNFLLQ--HSAKVNAKTK-NGYTPLHQAAQ 767
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMR 1185
GH ++ VL++ AS + G TA+ +A G+ +V+D ++
Sbjct: 768 QGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLK 811
Score = 149 bits (362), Expect = 8e-35
Identities = 127/458 (27%), Positives = 209/458 (45%), Gaps = 44/458 (9%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K +G +H A + + ++ LL+ G S+ T T +H+A +V L+ +
Sbjct: 396 KALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHH 455
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
GA + + ET LH+AAR + L++ GA +D TP+H++A+ G
Sbjct: 456 GASPNTT-NVRGETALHMAARSGQAE-VVRYLVQDGAQVEAKAKDDQTPLHISARLGKAD 513
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LL+ G P T +G TPL ++ R D+ F+ DH G S+S
Sbjct: 514 IVQQLLQQGASPNAAT-------TSGYTPLHLSAREGHEDVA----AFLLDH-GASLS-- 559
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVS-LQTRHNHETAFHYC 897
+ G + LH A K K EV A+ + K + A S L H A HY
Sbjct: 560 ---ITTKKGFTPLHVAAKYGKLEV----ANLLLQKSASPDAAGKSGLTPLH---VAAHY- 608
Query: 898 AIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
+N + ++ + + A N G+TPL IA + M + TLL A +
Sbjct: 609 ----DNQKVALLLLDQGASPHAAAKN-----GYTPLHIAAKKNQMDIATTLLEYGADANA 659
Query: 958 FDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRD 1017
+G +++HLAA+ G++ + LL A + +G T LHLAA ++ + L+ +
Sbjct: 660 VTRQGIASVHLAAQEGHVDMVSLLLGRNANV-----SGLTPLHLAAQEDRVNVAEVLV-N 713
Query: 1018 HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEV 1077
A +D T TPLH+ G I++ LL+ A ++A + G P+H AAQ ++ +
Sbjct: 714 QGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHI 773
Query: 1078 VQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEEL 1115
+ + LQ + + T +GNT IA G + V++ L
Sbjct: 774 INVLLQNNAS-PNELTVNGNTALGIARRLGYISVVDTL 810
Score = 87.0 bits (206), Expect = 6e-16
Identities = 55/162 (33%), Positives = 83/162 (51%), Gaps = 3/162 (1%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V + G P+ +A G+ ++V +L+ + T G+TALH+AAR ++ R LV
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPN--TTNVRGETALHMAARSGQAEVVRYLV 486
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
GA V+A QTPLHI+A G +V+ A+ A TP+HL+A GH
Sbjct: 487 QDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHED 546
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+ L D AS+ TK G T +H+A+ G + A +L +K
Sbjct: 547 VAAFLLD-HGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK 587
Score = 85.8 bits (203), Expect = 1e-15
Identities = 49/162 (30%), Positives = 81/162 (50%), Gaps = 2/162 (1%)
Query: 62 RGKVPL-LLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+GKV L L + A L Q + +G T LH+AA ++++A +L++
Sbjct: 198 KGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNR 257
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A VD T TPLH+A+ G+ +VK A + TP+H A +GH ++
Sbjct: 258 AAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVV 317
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGV 222
E+L D+ A I +TK+G + +H+A+ H +C +L + V
Sbjct: 318 EMLLDR-AAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNV 358
Score = 85.8 bits (203), Expect = 1e-15
Identities = 56/167 (33%), Positives = 86/167 (51%), Gaps = 3/167 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL +A + N+ V ELL A ++A T +G T +H+AA V++ L+ +GA
Sbjct: 400 GFTPLHIACKK-NRIKVMELLLKHGAS-IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGA 457
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ TN G+T LH+AA G +V+Y A +D+TP+H++A G A I++
Sbjct: 458 SPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQ 517
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L + AS T G T +H+++ GH D A L G L + K
Sbjct: 518 LLQQ-GASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTK 563
Score = 81.8 bits (193), Expect = 2e-14
Identities = 53/158 (33%), Positives = 77/158 (48%), Gaps = 3/158 (1%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL ++ G +V++LL Q A T +G T LHL+AR D+A L+D+GA
Sbjct: 500 QTPLHISARLGKADIVQQLL--QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGAS 557
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
+ T G TPLH+AA G + A+ A TP+H+AA + + LL
Sbjct: 558 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 617
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
D+ AS K+G T +HIA+ D A L + G
Sbjct: 618 LDQ-GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYG 654
Score = 74.1 bits (174), Expect = 5e-12
Identities = 52/152 (34%), Positives = 75/152 (49%), Gaps = 8/152 (5%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++G + LA + G+ MV LL + +G T LHLAA+ V++A +LV
Sbjct: 660 VTRQGIASVHLAAQEGHVDMVSLLLG-------RNANVSGLTPLHLAAQEDRVNVAEVLV 712
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
+ GA VDA G TPLH+ G+ +V + A TP+H AA+ GH
Sbjct: 713 NQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTH 772
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGH 210
II +L AS E T +G+T + IA G+
Sbjct: 773 IINVLLQN-NASPNELTVNGNTALGIARRLGY 803
Score = 73.3 bits (172), Expect = 8e-12
Identities = 43/125 (34%), Positives = 70/125 (56%), Gaps = 2/125 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
Q G L LA + G+ +V ELL Q + A T G+TALH+A+ ++ ++LV
Sbjct: 72 QNGLNALHLASKEGHVEVVSELL--QREANVDAATKKGNTALHIASLAGQAEVVKVLVTN 129
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+A + G TPL++AA E +VK+ A+ ++A + TP+ +A + GH ++
Sbjct: 130 GANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVV 189
Query: 181 ELLAD 185
LL +
Sbjct: 190 SLLLE 194
Score = 67.3 bits (157), Expect = 6e-10
Identities = 45/159 (28%), Positives = 73/159 (45%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL +G++ +V LL A + + T G + LH+A + ++ ++L+ +
Sbjct: 301 GLTPLHCGARSGHEQVVEMLLDR--AAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNV 358
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VD T LH+AA G + K +AN TP+H+A + ++EL
Sbjct: 359 PVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMEL 418
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L K ASI T+ G T +H+A+ GH + L G
Sbjct: 419 LL-KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHG 456
Score = 65.3 bits (152), Expect = 2e-09
Identities = 48/169 (28%), Positives = 79/169 (46%), Gaps = 8/169 (4%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL +A + G + LL Q + A +G T LH+AA + +A +L+D
Sbjct: 563 KKGFTPLHVAAKYGKLEVANLLL--QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 620
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA A G TPLHIAA + + A+A + +HLAA+ GH ++
Sbjct: 621 GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMV 680
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
LL + A++ G T +H+A+ + A +L +G ++ K
Sbjct: 681 SLLLGR-NANV-----SGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTK 723
Score = 62.5 bits (145), Expect = 2e-08
Identities = 44/159 (27%), Positives = 71/159 (44%), Gaps = 8/159 (5%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A + + LL + A T G ++HLAA+ VDM +L+
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTLL--EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGR 686
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A N +G TPLH+AA E + + A+ TP+H+ G+ I+
Sbjct: 687 NA-----NVSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIV 741
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
L + A + +TK+G T +H A+ GH +L +
Sbjct: 742 NFLL-QHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 779
Score = 56.0 bits (129), Expect = 1e-06
Identities = 48/169 (28%), Positives = 76/169 (44%), Gaps = 3/169 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A + + + V+ LL Q + T TALH+AA +A++L+D
Sbjct: 332 KNGLSPLHMATQGDHLNCVQLLL--QHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDK 389
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A +A G TPLHIA + +++ A+ TP+H+AA GH I+
Sbjct: 390 KANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIV 449
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L AS G T +H+A+ +G A+ L + G + K
Sbjct: 450 SQLM-HHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAK 497
Score = 49.2 bits (112), Expect = 2e-04
Identities = 29/117 (24%), Positives = 56/117 (47%), Gaps = 1/117 (0%)
Query: 105 AARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED 164
AAR ++ A + G ++ N G LH+A+ EG +V AN A +
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 165 RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
T +H+A+ G A ++++L A++ ++++G T +++A+ H + L G
Sbjct: 108 NTALHIASLAGQAEVVKVLVTN-GANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNG 163
Score = 46.4 bits (105), Expect = 0.001
Identities = 33/121 (27%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL LA + + V E+L Q A + A T G T LH+ ++ + L+ + A
Sbjct: 692 GLTPLHLAAQEDRVN-VAEVLVNQGAH-VDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSA 749
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+A G TPLH AA +G ++ A+ T + +A G+ ++++
Sbjct: 750 KVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDT 809
Query: 183 L 183
L
Sbjct: 810 L 810
>AL359267-1|CAH73232.1| 4372|Homo sapiens ankyrin 3, node of Ranvier
(ankyrin G) protein.
Length = 4372
Score = 313 bits (769), Expect = 4e-84
Identities = 229/752 (30%), Positives = 373/752 (49%), Gaps = 42/752 (5%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H A++ GHV +++ LLQ+ +VD T TALHIA + + VV+ L+ GA+
Sbjct: 73 NGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGAN 132
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V+ + + TPL++AA+ + + LL +GA + ATEDG TP+ VA + G+ +
Sbjct: 133 VNAQS-QNGFTPLYMAAQ-ENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVS 190
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDI---VRHLIEFVKDHKGESVSTA 838
LLLE+ D K ++ + + + A D V F H
Sbjct: 191 LLLEN--DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNI 248
Query: 839 FIDAVDEDGASALHYACK--VTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHY 896
+ + + A+A+ + + +T V + +VK L++ GA + +TR T H
Sbjct: 249 NVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGL-TPLHC 307
Query: 897 CAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVD 956
A +G+ V+ EM+ + +S+ N G +PL +A H+ V LL ++ VD
Sbjct: 308 GARSGHEQVV-EMLLDRAAPILSKTKN-----GLSPLHMATQGDHLNCVQLLLQHNVPVD 361
Query: 957 VFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIR 1016
+ +ALH+AA G+ +V LL KA N+KA NG T LH+A +++ L++
Sbjct: 362 DVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLK 421
Query: 1017 DHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSE 1076
H A I +T TP+H+AA G + + L+ GA+ + T+ G+ +H AA++ +E
Sbjct: 422 -HGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAE 480
Query: 1077 VVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPL 1136
VV+ +L Q V A KD T HI+A G ++++L++ G + TPL
Sbjct: 481 VVR-YLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQ---QGASPNAATTSGYTPL 536
Query: 1137 QLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
L+A GH DV L+ GAS + + G T +H+AA++G V +++ + ++ K
Sbjct: 537 HLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGK 596
Query: 1197 LGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGN 1256
GLTPLH+AA+Y + LL G S P A++G TPLH+AA
Sbjct: 597 SGLTPLHVAAHYDNQKVALLLLDQ-----------GAS--PHAAAKNGYTPLHIAAKKNQ 643
Query: 1257 ENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTG 1316
++ LL G A+A + + G +HLA GH+ +V LLL R+A + G T
Sbjct: 644 MDIATTLLEY-GADANAVTRQ-GIASVHLAAQEGHVDMVSLLLGRNANV------SGLTP 695
Query: 1317 LHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSET 1376
LH+A+ + EVL+ QGA ++A K G+TPLH G++ +V L + A ++T
Sbjct: 696 LHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKT 755
Query: 1377 NLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
P+ AA + H ++ LL L
Sbjct: 756 KNGYTPLHQAAQQGHTHIINVLLQNNASPNEL 787
Score = 284 bits (697), Expect = 2e-75
Identities = 227/764 (29%), Positives = 362/764 (47%), Gaps = 72/764 (9%)
Query: 656 EKYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETL 715
++ K D S AAR GH+ ++ G +++ + ALH+A + VV L
Sbjct: 34 DRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSEL 93
Query: 716 LGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
L A+V K+ T LHIA+ + + +L+ +GA N +++G TP+++AA+
Sbjct: 94 LQREANVD-AATKKGNTALHIAS-LAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQEN 151
Query: 776 NLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESV 835
+L + LL++G T+ G TPL +A + +V L+E D KG+
Sbjct: 152 HLEVVKFLLDNGASQSLATE-------DGFTPLAVALQQGHDQVVSLLLE--NDTKGKV- 201
Query: 836 STAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFH 895
ALH A + K++ K L++N + ++++ T H
Sbjct: 202 -----------RLPALHIAAR--KDDTK-------AAALLLQNDNNADVESKSGF-TPLH 240
Query: 896 YCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARV 955
A GN +V T ++ + D +N I TPL +A RG+ +V LL A++
Sbjct: 241 IAAHYGNINVATLLLNRAAAVD----FTARNDI--TPLHVASKRGNANMVKLLLDRGAKI 294
Query: 956 DVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLI 1015
D +G + LH A G+ QV + LL A I SK +NG + LH+A + + V+ L+
Sbjct: 295 DAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLL 354
Query: 1016 RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYS 1075
+ HN +D +T T LH+AA G +V K+LL+ AN +A G P+H A + N
Sbjct: 355 Q-HNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRI 413
Query: 1076 EVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTP 1135
+V++L L +H + A T+ G T H+AA G V ++ +LM G + T
Sbjct: 414 KVMELLL-KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLM---HHGASPNTTNVRGETA 469
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK 1195
L +AA G A+VVR LV+ GA + + T +H++A G +++ + ++
Sbjct: 470 LHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAAT 529
Query: 1196 KLGLTPLHIAAYYGQAETVRELLSHVPG----TVKSEAPTGV----------------SL 1235
G TPLH++A G + LL H T K P V S
Sbjct: 530 TSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSA 589
Query: 1236 VPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIV 1295
P +SGLTPLH+AA+ N+ V LLL+ G AA+ +NGY PLH+A M I
Sbjct: 590 SPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ-GASPHAAA-KNGYTPLHIAAKKNQMDIA 647
Query: 1296 GLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAK 1355
LL A+ ++ R G +H+A+ GH MV +LLG+ A + +G TPLH AA+
Sbjct: 648 TTLLEYGAD-ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV-----SGLTPLHLAAQ 701
Query: 1356 AGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+NV ++L GA ++T + P+ + ++ +LL
Sbjct: 702 EDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLL 745
Score = 270 bits (662), Expect = 4e-71
Identities = 220/720 (30%), Positives = 350/720 (48%), Gaps = 64/720 (8%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++ AA+ H+ ++ LL G S + T D +T L +A++ VV LL
Sbjct: 139 NGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTK 198
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
GK R LHIAAR D K A +LL++ + ++ G TP+H+AA +GN+
Sbjct: 199 -----GKVRLPALHIAAR-KDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVAT 252
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LLL + + TPL +A + ++V+ L++ +G A ID
Sbjct: 253 LLLN-------RAAAVDFTARNDITPLHVASKRGNANMVKLLLD-----RG-----AKID 295
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
A DG + LH + E QVV+ L++ A + +T+ N + H
Sbjct: 296 AKTRDGLTPLHCGARSGHE---------QVVEMLLDRAAPILSKTK-NGLSPLHMATQGD 345
Query: 902 NNDVMTEMIAH-ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDV 960
+ + + ++ H + DV+ T L +A H GH ++ LL A + +
Sbjct: 346 HLNCVQLLLQHNVPVDDVTNDY-------LTALHVAAHCGHYKVAKVLLDKKANPNAKAL 398
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
G + LH+A + ++V + LL + A I + +G T +H+AA G+ ++V L+ H A
Sbjct: 399 NGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH-HGA 457
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQL 1080
+ ++ +T LH+AA SGQ EV + L++ GA ++A + Q P+H +A+ +++VQ
Sbjct: 458 SPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQ 517
Query: 1081 FLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAA 1140
LQQ + ATT G T H++A +G V L+ D +S K TPL +AA
Sbjct: 518 LLQQGASPNAATTS-GYTPLHLSAREGHEDVAAFLL--DHGASLSITTK-KGFTPLHVAA 573
Query: 1141 EGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLT 1200
+ G +V +L++ AS ++GLT +H+AA + + V ++ ++ K G T
Sbjct: 574 KYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYT 633
Query: 1201 PLHIAAYYGQAETVRELLSHVP----------GTVKSEAPTG-VSLVPVLGAE----SGL 1245
PLHIAA Q + LL + +V A G V +V +L SGL
Sbjct: 634 PLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVSGL 693
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
TPLHLAA NV +L+N G DA + + GY PLH+ C G++ IV LL SA++
Sbjct: 694 TPLHLAAQEDRVNVAEVLVNQ-GAHVDAQT-KMGYTPLHVGCHYGNIKIVNFLLQHSAKV 751
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
T ++G T LH A+ GH ++ VLL A N NG T L A + G+++VV L
Sbjct: 752 NAKT-KNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 810
Score = 256 bits (627), Expect = 6e-67
Identities = 211/692 (30%), Positives = 331/692 (47%), Gaps = 66/692 (9%)
Query: 737 AARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKV 796
AAR +K AL +K+G N ++G+ +H+A+K G++ + LL+ + TK
Sbjct: 48 AARAGHLEK-ALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATK- 105
Query: 797 CIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACK 856
G T L +A + ++V+ L+ + A ++A ++G + L+ A +
Sbjct: 106 ------KGNTALHIASLAGQAEVVKVLV----------TNGANVNAQSQNGFTPLYMAAQ 149
Query: 857 VTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTA 916
EV VK L++NGA SL T T G++ V++ ++ +
Sbjct: 150 ENHLEV---------VKFLLDNGASQSLATEDGF-TPLAVALQQGHDQVVSLLLEN---- 195
Query: 917 DVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQ 976
+ + + L IA + + LL N DV G + LH+AA +G +
Sbjct: 196 ------DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNIN 249
Query: 977 VCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLA 1036
V LL A ++ ARN T LH+A+ G A++VK L+ D A ID T TPLH
Sbjct: 250 VATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLL-DRGAKIDAKTRDGLTPLHCG 308
Query: 1037 AASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDG 1096
A SG +V ++LL+ A I + + G P+H A Q ++ VQL LQ H V T D
Sbjct: 309 ARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ-HNVPVDDVTNDY 367
Query: 1097 NTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGA 1156
T H+AA G KV + L+ D+ +A+ LN TPL +A + V+ +L++ GA
Sbjct: 368 LTALHVAAHCGHYKVAKVLL--DKKANPNAK-ALNGFTPLHIACKKNRIKVMELLLKHGA 424
Query: 1157 SCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRE 1216
S +GLT +H+AA GH N++ + ++ G T LH+AA GQAE VR
Sbjct: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484
Query: 1217 LL---SHVPGTVKSE-APTGVSL----------------VPVLGAESGLTPLHLAAYNGN 1256
L+ + V K + P +S P SG TPLHL+A G+
Sbjct: 485 LVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGH 544
Query: 1257 ENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTG 1316
E+V LL+ + + + + G+ PLH+A G + + LLL +SA + + G T
Sbjct: 545 EDVAAFLLDHGA--SLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP-DAAGKSGLTP 601
Query: 1317 LHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSET 1376
LH+A+ + + ++ +LL QGA +A KNG+TPLH AAK +++ L E GA + T
Sbjct: 602 LHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVT 661
Query: 1377 NLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
A + AA E H D++ LL + + L
Sbjct: 662 RQGIASVHLAAQEGHVDMVSLLLGRNANVSGL 693
Score = 247 bits (605), Expect = 3e-64
Identities = 176/546 (32%), Positives = 279/546 (51%), Gaps = 37/546 (6%)
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
+N N G L +A GH+++V+ LL A VD +G +ALH+A+ G +V L
Sbjct: 67 INICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVL 126
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
+TN A +N++++NG T L++AA + +VKFL+ D+ A + T TPL +A G
Sbjct: 127 VTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLL-DNGASQSLATEDGFTPLAVALQQGH 185
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAH 1101
+V LLLE D ++ +H AA+ + ++ L LQ N + + K G T H
Sbjct: 186 DQVVSLLLEN----DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVES-KSGFTPLH 240
Query: 1102 IAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDE 1161
IAA G++ V L+ +ARN D TPL +A++ G+A++V++L+ GA +
Sbjct: 241 IAAHYGNINVATLLLNRAAAVDFTARN---DITPLHVASKRGNANMVKLLLDRGAKIDAK 297
Query: 1162 NRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSH- 1220
R GLT +H A GH V++++ +S K GL+PLH+A V+ LL H
Sbjct: 298 TRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHN 357
Query: 1221 VP-GTVKSEAPTGVSLVPVLG------------------AESGLTPLHLAAYNGNENVVR 1261
VP V ++ T + + G A +G TPLH+A V+
Sbjct: 358 VPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVME 417
Query: 1262 LLL-NSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIA 1320
LLL + A +QA E+G P+H+A F GH++IV L+ A ++T+ G+T LH+A
Sbjct: 418 LLLKHGASIQA---VTESGLTPIHVAAFMGHVNIVSQLMHHGASP-NTTNVRGETALHMA 473
Query: 1321 STHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNC 1380
+ G ++V L+ GA++ A K+ TPLH +A+ G ++V+ L + GASP + T
Sbjct: 474 ARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGY 533
Query: 1381 APIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAP 1440
P+ +A E H DV +LL +H + K+ L V +K + + + +L A
Sbjct: 534 TPLHLSAREGHEDVAAFLL--DHGASLSITTKKGFTPLHVAAK-YGKLEVANLLLQKSAS 590
Query: 1441 VDTAAK 1446
D A K
Sbjct: 591 PDAAGK 596
Score = 206 bits (502), Expect = 9e-52
Identities = 156/524 (29%), Positives = 256/524 (48%), Gaps = 45/524 (8%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G +H A + H+ + LLQ VD TND TALH+A V + LL A+
Sbjct: 333 NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN 392
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ + TPLHIA + + K +LLK GA TE G+TP+HVAA G++ +
Sbjct: 393 PNAKA-LNGFTPLHIACK-KNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVS 450
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
L+ G P V GET L MA RS ++VR+L++ A ++
Sbjct: 451 QLMHHGASPNTTN-------VRGETALHMAARSGQAEVVRYLVQ----------DGAQVE 493
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
A +D + LH + ++ K ++ V+ L++ GA + T + T H A G
Sbjct: 494 AKAKDDQTPLHISARLGKADI---------VQQLLQQGASPNAATTSGY-TPLHLSAREG 543
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ DV ++ H ++ ++ G+TPL +A G +++ N LL A D
Sbjct: 544 HEDVAAFLLDHGASLSIT------TKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKS 597
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM 1021
G + LH+AA + +V LL A ++ A+NG T LH+AA + L+ ++ A
Sbjct: 598 GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLL-EYGAD 656
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
+ +T + +HLAA G +++ LLL AN+ G P+H AAQ + V ++
Sbjct: 657 ANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVS-----GLTPLHLAAQEDRVNVAEVL 711
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
+ Q + V A TK G T H+ G++K++ L++ + ++A+ K N TPL AA+
Sbjct: 712 VNQGAH-VDAQTKMGYTPLHVGCHYGNIKIVNFLLQ--HSAKVNAKTK-NGYTPLHQAAQ 767
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMR 1185
GH ++ VL++ AS + G TA+ +A G+ +V+D ++
Sbjct: 768 QGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLK 811
Score = 149 bits (362), Expect = 8e-35
Identities = 127/458 (27%), Positives = 209/458 (45%), Gaps = 44/458 (9%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K +G +H A + + ++ LL+ G S+ T T +H+A +V L+ +
Sbjct: 396 KALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHH 455
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
GA + + ET LH+AAR + L++ GA +D TP+H++A+ G
Sbjct: 456 GASPNTT-NVRGETALHMAARSGQAE-VVRYLVQDGAQVEAKAKDDQTPLHISARLGKAD 513
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LL+ G P T +G TPL ++ R D+ F+ DH G S+S
Sbjct: 514 IVQQLLQQGASPNAAT-------TSGYTPLHLSAREGHEDVA----AFLLDH-GASLS-- 559
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVS-LQTRHNHETAFHYC 897
+ G + LH A K K EV A+ + K + A S L H A HY
Sbjct: 560 ---ITTKKGFTPLHVAAKYGKLEV----ANLLLQKSASPDAAGKSGLTPLH---VAAHY- 608
Query: 898 AIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
+N + ++ + + A N G+TPL IA + M + TLL A +
Sbjct: 609 ----DNQKVALLLLDQGASPHAAAKN-----GYTPLHIAAKKNQMDIATTLLEYGADANA 659
Query: 958 FDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRD 1017
+G +++HLAA+ G++ + LL A + +G T LHLAA ++ + L+ +
Sbjct: 660 VTRQGIASVHLAAQEGHVDMVSLLLGRNANV-----SGLTPLHLAAQEDRVNVAEVLV-N 713
Query: 1018 HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEV 1077
A +D T TPLH+ G I++ LL+ A ++A + G P+H AAQ ++ +
Sbjct: 714 QGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHI 773
Query: 1078 VQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEEL 1115
+ + LQ + + T +GNT IA G + V++ L
Sbjct: 774 INVLLQNNAS-PNELTVNGNTALGIARRLGYISVVDTL 810
Score = 87.0 bits (206), Expect = 6e-16
Identities = 55/162 (33%), Positives = 83/162 (51%), Gaps = 3/162 (1%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V + G P+ +A G+ ++V +L+ + T G+TALH+AAR ++ R LV
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPN--TTNVRGETALHMAARSGQAEVVRYLV 486
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
GA V+A QTPLHI+A G +V+ A+ A TP+HL+A GH
Sbjct: 487 QDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHED 546
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+ L D AS+ TK G T +H+A+ G + A +L +K
Sbjct: 547 VAAFLLD-HGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK 587
Score = 85.8 bits (203), Expect = 1e-15
Identities = 49/162 (30%), Positives = 81/162 (50%), Gaps = 2/162 (1%)
Query: 62 RGKVPL-LLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+GKV L L + A L Q + +G T LH+AA ++++A +L++
Sbjct: 198 KGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNR 257
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A VD T TPLH+A+ G+ +VK A + TP+H A +GH ++
Sbjct: 258 AAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVV 317
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGV 222
E+L D+ A I +TK+G + +H+A+ H +C +L + V
Sbjct: 318 EMLLDR-AAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNV 358
Score = 85.8 bits (203), Expect = 1e-15
Identities = 56/167 (33%), Positives = 86/167 (51%), Gaps = 3/167 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL +A + N+ V ELL A ++A T +G T +H+AA V++ L+ +GA
Sbjct: 400 GFTPLHIACKK-NRIKVMELLLKHGAS-IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGA 457
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ TN G+T LH+AA G +V+Y A +D+TP+H++A G A I++
Sbjct: 458 SPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQ 517
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L + AS T G T +H+++ GH D A L G L + K
Sbjct: 518 LLQQ-GASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTK 563
Score = 81.8 bits (193), Expect = 2e-14
Identities = 53/158 (33%), Positives = 77/158 (48%), Gaps = 3/158 (1%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL ++ G +V++LL Q A T +G T LHL+AR D+A L+D+GA
Sbjct: 500 QTPLHISARLGKADIVQQLL--QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGAS 557
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
+ T G TPLH+AA G + A+ A TP+H+AA + + LL
Sbjct: 558 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 617
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
D+ AS K+G T +HIA+ D A L + G
Sbjct: 618 LDQ-GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYG 654
Score = 74.1 bits (174), Expect = 5e-12
Identities = 52/152 (34%), Positives = 75/152 (49%), Gaps = 8/152 (5%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++G + LA + G+ MV LL + +G T LHLAA+ V++A +LV
Sbjct: 660 VTRQGIASVHLAAQEGHVDMVSLLLG-------RNANVSGLTPLHLAAQEDRVNVAEVLV 712
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
+ GA VDA G TPLH+ G+ +V + A TP+H AA+ GH
Sbjct: 713 NQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTH 772
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGH 210
II +L AS E T +G+T + IA G+
Sbjct: 773 IINVLLQN-NASPNELTVNGNTALGIARRLGY 803
Score = 73.3 bits (172), Expect = 8e-12
Identities = 43/125 (34%), Positives = 70/125 (56%), Gaps = 2/125 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
Q G L LA + G+ +V ELL Q + A T G+TALH+A+ ++ ++LV
Sbjct: 72 QNGLNALHLASKEGHVEVVSELL--QREANVDAATKKGNTALHIASLAGQAEVVKVLVTN 129
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+A + G TPL++AA E +VK+ A+ ++A + TP+ +A + GH ++
Sbjct: 130 GANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVV 189
Query: 181 ELLAD 185
LL +
Sbjct: 190 SLLLE 194
Score = 67.3 bits (157), Expect = 6e-10
Identities = 45/159 (28%), Positives = 73/159 (45%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL +G++ +V LL A + + T G + LH+A + ++ ++L+ +
Sbjct: 301 GLTPLHCGARSGHEQVVEMLLDR--AAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNV 358
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VD T LH+AA G + K +AN TP+H+A + ++EL
Sbjct: 359 PVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMEL 418
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L K ASI T+ G T +H+A+ GH + L G
Sbjct: 419 LL-KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHG 456
Score = 65.3 bits (152), Expect = 2e-09
Identities = 48/169 (28%), Positives = 79/169 (46%), Gaps = 8/169 (4%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL +A + G + LL Q + A +G T LH+AA + +A +L+D
Sbjct: 563 KKGFTPLHVAAKYGKLEVANLLL--QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 620
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA A G TPLHIAA + + A+A + +HLAA+ GH ++
Sbjct: 621 GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMV 680
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
LL + A++ G T +H+A+ + A +L +G ++ K
Sbjct: 681 SLLLGR-NANV-----SGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTK 723
Score = 62.5 bits (145), Expect = 2e-08
Identities = 44/159 (27%), Positives = 71/159 (44%), Gaps = 8/159 (5%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A + + LL + A T G ++HLAA+ VDM +L+
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTLL--EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGR 686
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A N +G TPLH+AA E + + A+ TP+H+ G+ I+
Sbjct: 687 NA-----NVSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIV 741
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
L + A + +TK+G T +H A+ GH +L +
Sbjct: 742 NFLL-QHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 779
Score = 56.0 bits (129), Expect = 1e-06
Identities = 48/169 (28%), Positives = 76/169 (44%), Gaps = 3/169 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A + + + V+ LL Q + T TALH+AA +A++L+D
Sbjct: 332 KNGLSPLHMATQGDHLNCVQLLL--QHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDK 389
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A +A G TPLHIA + +++ A+ TP+H+AA GH I+
Sbjct: 390 KANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIV 449
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L AS G T +H+A+ +G A+ L + G + K
Sbjct: 450 SQLM-HHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAK 497
Score = 49.2 bits (112), Expect = 2e-04
Identities = 29/117 (24%), Positives = 56/117 (47%), Gaps = 1/117 (0%)
Query: 105 AARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED 164
AAR ++ A + G ++ N G LH+A+ EG +V AN A +
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 165 RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
T +H+A+ G A ++++L A++ ++++G T +++A+ H + L G
Sbjct: 108 NTALHIASLAGQAEVVKVLVTN-GANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNG 163
Score = 46.4 bits (105), Expect = 0.001
Identities = 33/121 (27%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL LA + + V E+L Q A + A T G T LH+ ++ + L+ + A
Sbjct: 692 GLTPLHLAAQEDRVN-VAEVLVNQGAH-VDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSA 749
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+A G TPLH AA +G ++ A+ T + +A G+ ++++
Sbjct: 750 KVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDT 809
Query: 183 L 183
L
Sbjct: 810 L 810
>Z26634-1|CAB42644.1| 3925|Homo sapiens ankyrin B (440 kDa) protein.
Length = 3925
Score = 313 bits (768), Expect = 5e-84
Identities = 232/738 (31%), Positives = 361/738 (48%), Gaps = 52/738 (7%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H AA+ GHVG++ LL +G SVD T TALHIA + + VV+ L+ GA+
Sbjct: 63 NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGAN 122
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
++ + + TPL++AA+ D LL++GA + ATEDG TP+ VA + G+ +
Sbjct: 123 INAQ-SQNGFTPLYMAAQENHID-VVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
+LLE+ D K ++ L +A R D + DH + S ++
Sbjct: 181 ILLEN--DTKGKVRL---------PALHIAARK--DDTKSAALLLQNDHNADVQSKMMVN 227
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
E G + LH A + V L+ GA V T N T H + G
Sbjct: 228 RTTESGFTPLHIAAHY---------GNVNVATLLLNRGAAVDF-TARNGITPLHVASKRG 277
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
N +++ ++ D ++ + G TPL A GH Q+V LL A +
Sbjct: 278 NTNMVKLLL------DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 331
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM 1021
G S LH+AA+ +++ LL +KA ++ + TALH+AA G+ + K L+ D A
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLL-DKRAN 390
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
+ L TPLH+A +I+V +LL++ GA+I A E G PIH AA + +V L
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
LQ + + + G T H+AA G V+V+ L+ R G + + TPL +A+
Sbjct: 451 LQNGASPDVTNIR-GETALHMAARAGQVEVVRCLL---RNGALVDARAREEQTPLHIASR 506
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTP 1201
G ++V++L++ A G T +H++A G +V V+ + K G TP
Sbjct: 507 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 566
Query: 1202 LHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVR 1261
LH+AA YG + + LL ++ A + ++GLTPLH+AA+ N+ V
Sbjct: 567 LHVAAKYGSLDVAKLLLQR-----RAAADS--------AGKNGLTPLHVAAHYDNQKVAL 613
Query: 1262 LLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIAS 1321
LLL + A+ +NGY PLH+A M I LL+ AE + + G T LH+AS
Sbjct: 614 LLLEKGA--SPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE-TNIVTKQGVTPLHLAS 670
Query: 1322 THGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCA 1381
GH MV +LL +GA I+ + K+G T LH AA+ +NV +L + GA + T L
Sbjct: 671 QEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 730
Query: 1382 PIWFAASENHNDVLEYLL 1399
P+ A + ++ +LL
Sbjct: 731 PLIVACHYGNVKMVNFLL 748
Score = 294 bits (721), Expect = 3e-78
Identities = 240/796 (30%), Positives = 378/796 (47%), Gaps = 57/796 (7%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K D S AAR G++ + L+ G ++ + ALH+A + +V+ LLG
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
G+ V K+ T LHIA+ + + +L+K GA N +++G TP+++AA+ ++
Sbjct: 87 GSSVD-SATKKGNTALHIAS-LAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHID 144
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LLE+G + T+ G TPL +A + V L+E D KG+ A
Sbjct: 145 VVKYLLENGANQSTATE-------DGFTPLAVALQQGHNQAVAILLE--NDTKGKVRLPA 195
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
A +D + A + + + + +V E+G T H A
Sbjct: 196 LHIAARKDDTKS---AALLLQNDHNADVQSKMMVNRTTESGF-----------TPLHIAA 241
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVF 958
GN +V T ++ + D + A N G TPL +A RG+ +V LL ++D
Sbjct: 242 HYGNVNVATLLLNRGAAVDFT-ARN-----GITPLHVASKRGNTNMVKLLLDRGGQIDAK 295
Query: 959 DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH 1018
+G + LH AA G+ QV + LL A + ++ +NG + LH+AA + VK L++ H
Sbjct: 296 TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ-H 354
Query: 1019 NAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVV 1078
A +D +TL T LH+AA G V KLLL+ AN +A G P+H A + N +V+
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVM 414
Query: 1079 QLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQL 1138
+L L ++ + A T+ G T H+AA G + ++ L+ + G + T L +
Sbjct: 415 EL-LVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLL---QNGASPDVTNIRGETALHM 470
Query: 1139 AAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLG 1198
AA G +VVR L+R GA R T +H+A+ G T ++ ++ ++ G
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 530
Query: 1199 LTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNEN 1258
TPLHI+A GQ + LL G S L + G TPLH+AA G+ +
Sbjct: 531 YTPLHISAREGQVDVASVLLE--AGAAHS-----------LATKKGFTPLHVAAKYGSLD 577
Query: 1259 VVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH 1318
V +LLL AD+A +NG PLH+A + + LLL + A H+T ++G T LH
Sbjct: 578 VAKLLLQRRAA-ADSA-GKNGLTPLHVAAHYDNQKVALLLLEKGAS-PHATAKNGYTPLH 634
Query: 1319 IASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNL 1378
IA+ Q+ LL GAE N K G TPLH A++ GH ++V LL + GA+ T
Sbjct: 635 IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 694
Query: 1379 NCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSP 1438
+ AA E+ +V + L D + + Y ++ + ++ N+ + F+L
Sbjct: 695 GLTSLHLAAQEDKVNVADILTKHGADQDA---HTKLGYTPLIVACHYGNVKMVNFLLKQG 751
Query: 1439 APVDTAAKLSNIYINL 1454
A V+ AK N Y L
Sbjct: 752 ANVN--AKTKNGYTPL 765
Score = 293 bits (719), Expect = 4e-78
Identities = 224/724 (30%), Positives = 361/724 (49%), Gaps = 70/724 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++ AA+ H+ ++ LL+ G + T D +T L +A++ V LL
Sbjct: 129 NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK 188
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALML-------LKSGAGPNKATEDGMTPVHVAAKF 774
GK R LHIAAR D AL+L ++S N+ TE G TP+H+AA +
Sbjct: 189 -----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 243
Query: 775 GNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGES 834
GN+ LLL G + G TPL +A + ++V+ L+ D G+
Sbjct: 244 GNVNVATLLLNRGA-------AVDFTARNGITPLHVASKRGNTNMVKLLL----DRGGQ- 291
Query: 835 VSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAF 894
IDA DG + LH A + + QVV+ L+E GA + +T+ N +
Sbjct: 292 -----IDAKTRDGLTPLHCAAR---------SGHDQVVELLLERGAPLLARTK-NGLSPL 336
Query: 895 HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
H A + + + ++ H + D L+ T L +A H GH ++ LL A
Sbjct: 337 HMAAQGDHVECVKHLLQHKAPVD-DVTLDYL-----TALHVAAHCGHYRVTKLLLDKRAN 390
Query: 955 VDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
+ + G + LH+A + ++V + L+ A I + +G T +H+AA G+ ++V L
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Query: 1015 IRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNY 1074
+++ A DV ++ +T LH+AA +GQ+EV + LL GA +DA Q P+H A++
Sbjct: 451 LQN-GASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGK 509
Query: 1075 SEVVQLFLQQ--HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLND 1132
+E+VQL LQ HP+ A T +G T HI+A +G V V L++ ++ +
Sbjct: 510 TEIVQLLLQHMAHPD---AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF-- 564
Query: 1133 STPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
TPL +AA+ G DV ++L++ A+ + GLT +H+AA + + V ++
Sbjct: 565 -TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 623
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPLHIAA Q + LL++ A T + + G+TPLHLA+
Sbjct: 624 ATAKNGYTPLHIAAKKNQMQIASTLLNY-------GAETNIV------TKQGVTPLHLAS 670
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
G+ ++V LLL+ G S ++G LHLA +++ +L A+ T +
Sbjct: 671 QEGHTDMVTLLLDK-GANIHM-STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHT-KL 727
Query: 1313 GKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASP 1372
G T L +A +G+ +MV LL QGA +NA KNG+TPLH AA+ GH +++ +L + GA P
Sbjct: 728 GYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787
Query: 1373 KSET 1376
+ T
Sbjct: 788 NATT 791
Score = 256 bits (626), Expect = 8e-67
Identities = 211/685 (30%), Positives = 322/685 (47%), Gaps = 64/685 (9%)
Query: 666 SIHTAARYGHVGIINTLLQKGESVDV--------TTNDNYTALHIAVESCKPAVVETLLG 717
++H AAR LLQ + DV TT +T LHIA V LL
Sbjct: 195 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 254
Query: 718 YGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
GA V + TPLH+A++ + + L+L + G K T DG+TP+H AA+ G+
Sbjct: 255 RGAAVDFTA-RNGITPLHVASKRGNTNMVKLLLDRGGQIDAK-TRDGLTPLHCAARSGHD 312
Query: 778 ATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVST 837
+ LLLE G L +TK G +PL MA + + V+HL++ HK
Sbjct: 313 QVVELLLERGAPLLARTK-------NGLSPLHMAAQGDHVECVKHLLQ----HK------ 355
Query: 838 AFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYC 897
A +D V D +ALH A +V K L++ A+ + + N T H
Sbjct: 356 APVDDVTLDYLTALHVAAHC---------GHYRVTKLLLDKRANPNARAL-NGFTPLHIA 405
Query: 898 AIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
VM ++ + ++ G TP+ +A GH+ +V LL N A DV
Sbjct: 406 CKKNRIKVMELLVKY------GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 958 FDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRD 1017
++ G +ALH+AA G ++V LL N A ++++AR +T LH+A+ G +V+ L++
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ- 518
Query: 1018 HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEV 1077
H A D T TPLH++A GQ++V +LLE GA + G P+H AA+ +V
Sbjct: 519 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 578
Query: 1078 VQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
+L LQ+ + K+G T H+AA + KV L++ + +A+ N TPL
Sbjct: 579 AKLLLQRRA-AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK---NGYTPLH 634
Query: 1138 LAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKL 1197
+AA+ + L+ GA + G+T +HLA++ GHT+++ ++ S K
Sbjct: 635 IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 694
Query: 1198 GLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNE 1257
GLT LH+AA + L H +A T + G TPL +A + GN
Sbjct: 695 GLTSLHLAAQEDKVNVADILTKH---GADQDAHT----------KLGYTPLIVACHYGNV 741
Query: 1258 NVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGL 1317
+V LL G + A +NGY PLH A GH I+ +LL A+ ++T +G T L
Sbjct: 742 KMVNFLLKQ-GANVN-AKTKNGYTPLHQAAQQGHTHIINVLLQHGAK-PNATTANGNTAL 798
Query: 1318 HIASTHGHYQMVEVLLGQGAEINAT 1342
IA G+ +V+ L E+ T
Sbjct: 799 AIAKRLGYISVVDTLKVVTEEVTTT 823
Score = 89.0 bits (211), Expect = 2e-16
Identities = 46/134 (34%), Positives = 75/134 (55%), Gaps = 1/134 (0%)
Query: 86 QTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEP 145
Q+ + TT +G T LH+AA +V++A +L++ GA VD T G TPLH+A+ G+
Sbjct: 221 QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTN 280
Query: 146 LVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIA 205
+VK + TP+H AA +GH ++ELL ++ A + RTK+G + +H+A
Sbjct: 281 MVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER-GAPLLARTKNGLSPLHMA 339
Query: 206 SLNGHADCAMMLFK 219
+ H +C L +
Sbjct: 340 AQGDHVECVKHLLQ 353
Score = 86.6 bits (205), Expect = 8e-16
Identities = 54/173 (31%), Positives = 79/173 (45%), Gaps = 3/173 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D G PL ++ G + LL A A L T G T LH+AA+ +D+A++
Sbjct: 524 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL--ATKKGFTPLHVAAKYGSLDVAKL 581
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+ A D+ G TPLH+AA ++ + A+ TP+H+AA+
Sbjct: 582 LLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQ 641
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
I L + + A TK G T +H+AS GH D +L KG +HM K
Sbjct: 642 MQIASTLLN-YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTK 693
Score = 84.2 bits (199), Expect = 4e-15
Identities = 53/162 (32%), Positives = 82/162 (50%), Gaps = 3/162 (1%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
+ + G P+ +A G+ ++V LL Q T G+TALH+AAR V++ R L+
Sbjct: 427 ITESGLTPIHVAAFMGHLNIV--LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLL 484
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
GA+VDA QTPLHIA+ G +V+ A+ A TP+H++A G
Sbjct: 485 RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVD 544
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+ +L + A TK G T +H+A+ G D A +L ++
Sbjct: 545 VASVLLEAGAAHSL-ATKKGFTPLHVAAKYGSLDVAKLLLQR 585
Score = 83.4 bits (197), Expect = 8e-15
Identities = 54/164 (32%), Positives = 82/164 (50%), Gaps = 3/164 (1%)
Query: 58 LVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARIL 117
L ++G PL +A + G+ + + LL + A G T LH+AA + +A +L
Sbjct: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN--GLTPLHVAAHYDNQKVALLL 615
Query: 118 VDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
++ GA AT G TPLHIAA + + A I + TP+HLA++ GH
Sbjct: 616 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 675
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
++ LL DK A+I TK G T +H+A+ + A +L K G
Sbjct: 676 DMVTLLLDK-GANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG 718
Score = 79.0 bits (186), Expect = 2e-13
Identities = 53/154 (34%), Positives = 79/154 (51%), Gaps = 3/154 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
++V ++G PL LA + G+ MV LL + +T +G T+LHLAA+ V++A I
Sbjct: 656 NIVTKQGVTPLHLASQEGHTDMVTLLLDK--GANIHMSTKSGLTSLHLAAQEDKVNVADI 713
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L +GA DA G TPL +A G+ +V + AN TP+H AA+ GH
Sbjct: 714 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 773
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
II +L + A T +G+T + IA G+
Sbjct: 774 THIINVLL-QHGAKPNATTANGNTALAIAKRLGY 806
Score = 77.8 bits (183), Expect = 4e-13
Identities = 55/166 (33%), Positives = 77/166 (46%), Gaps = 3/166 (1%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL +A G +V+ LL Q A T G T LH++AR VD+A +L++ GA
Sbjct: 498 QTPLHIASRLGKTEIVQLLL--QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
G TPLH+AA G + K RA A A TP+H+AA + + LL
Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+K AS K+G T +HIA+ A L G ++ K
Sbjct: 616 LEK-GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 660
Score = 75.8 bits (178), Expect = 2e-12
Identities = 52/159 (32%), Positives = 83/159 (52%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL +A + N+ V ELL A ++A T +G T +H+AA +++ +L+ GA
Sbjct: 398 GFTPLHIACKK-NRIKVMELLVKYGAS-IQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 455
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
D TN G+T LH+AA G +V+ A E++TP+H+A+ G I++L
Sbjct: 456 SPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 515
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L + A T +G T +HI++ G D A +L + G
Sbjct: 516 LL-QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 553
Score = 73.3 bits (172), Expect = 8e-12
Identities = 52/170 (30%), Positives = 86/170 (50%), Gaps = 15/170 (8%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV--DY 120
G PL +A++ G+ V LL T +++ ALH+AAR+ D A +L+ D+
Sbjct: 163 GFTPLAVALQQGHNQAVAILLENDTKGKVRLP------ALHIAARKDDTKSAALLLQNDH 216
Query: 121 GA------VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAEN 174
A +V+ T +G TPLHIAA G+ + A TP+H+A++
Sbjct: 217 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR 276
Query: 175 GHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
G+ +++LL D+ I +T+DG T +H A+ +GH +L ++G L
Sbjct: 277 GNTNMVKLLLDR-GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
Score = 72.9 bits (171), Expect = 1e-11
Identities = 54/165 (32%), Positives = 79/165 (47%), Gaps = 3/165 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D + G PL +A + GN +MV+ LL Q+ A T G T LH AAR + +
Sbjct: 260 DFTARNGITPLHVASKRGNTNMVKLLLDR--GGQIDAKTRDGLTPLHCAARSGHDQVVEL 317
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L++ GA + A G +PLH+AA VK+ +A + T +H+AA GH
Sbjct: 318 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGH 377
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ +LL DK +A+ R +G T +HIA +L K G
Sbjct: 378 YRVTKLLLDK-RANPNARALNGFTPLHIACKKNRIKVMELLVKYG 421
Score = 71.7 bits (168), Expect = 3e-11
Identities = 41/125 (32%), Positives = 70/125 (56%), Gaps = 2/125 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
Q G L LA + G+ +V+ELL ++ + + T G+TALH+A+ ++ ++LV
Sbjct: 62 QNGLNALHLAAKEGHVGLVQELLGRGSS--VDSATKKGNTALHIASLAGQAEVVKVLVKE 119
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA ++A + G TPL++AA E +VKY AN + A + TP+ +A + GH +
Sbjct: 120 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAV 179
Query: 181 ELLAD 185
+L +
Sbjct: 180 AILLE 184
Score = 64.1 bits (149), Expect = 5e-09
Identities = 47/161 (29%), Positives = 74/161 (45%), Gaps = 3/161 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A + NQ + L AE T G T LHLA++ DM +L+D
Sbjct: 627 KNGYTPLHIAAKK-NQMQIASTLLNYGAET-NIVTKQGVTPLHLASQEGHTDMVTLLLDK 684
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA + + +G T LH+AA E + A+ TP+ +A G+ ++
Sbjct: 685 GANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMV 744
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L K A++ +TK+G T +H A+ GH +L + G
Sbjct: 745 NFLL-KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHG 784
Score = 54.4 bits (125), Expect = 4e-06
Identities = 46/161 (28%), Positives = 71/161 (44%), Gaps = 3/161 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A + + V+ LL Q + T TALH+AA + ++L+D
Sbjct: 330 KNGLSPLHMAAQGDHVECVKHLL--QHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDK 387
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A +A G TPLHIA + +++ A+ TP+H+AA GH I+
Sbjct: 388 RANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIV 447
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LL AS G T +H+A+ G + L + G
Sbjct: 448 LLLLQN-GASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 487
Score = 53.2 bits (122), Expect = 1e-05
Identities = 33/117 (28%), Positives = 60/117 (51%), Gaps = 1/117 (0%)
Query: 105 AARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED 164
AAR ++D + G ++ N G LH+AA EG LV+ G ++ A +
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 165 RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
T +H+A+ G A ++++L K A+I ++++G T +++A+ H D L + G
Sbjct: 98 NTALHIASLAGQAEVVKVLV-KEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
Score = 49.6 bits (113), Expect = 1e-04
Identities = 36/130 (27%), Positives = 64/130 (49%), Gaps = 9/130 (6%)
Query: 135 LHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFER 194
L A A + +V+Y G + + +HLAA+ GH +++ L + +S+
Sbjct: 36 LRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLGR-GSSVDSA 93
Query: 195 TKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK------YFEKQ-TFDEVLFVKIENG 247
TK G+T +HIASL G A+ +L K+G ++ ++ Y Q +V+ +ENG
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
Query: 248 LIKGLKSDDG 257
+ ++DG
Sbjct: 154 ANQSTATEDG 163
Score = 42.7 bits (96), Expect = 0.014
Identities = 24/54 (44%), Positives = 31/54 (57%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETL 715
+G +H AA+ GH IIN LLQ G + TT + TAL IA +VV+TL
Sbjct: 760 NGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
>X56958-1|CAA40279.2| 1872|Homo sapiens ankyrin (brank-2) protein.
Length = 1872
Score = 313 bits (768), Expect = 5e-84
Identities = 232/738 (31%), Positives = 361/738 (48%), Gaps = 52/738 (7%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H AA+ GHVG++ LL +G SVD T TALHIA + + VV+ L+ GA+
Sbjct: 63 NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGAN 122
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
++ + + TPL++AA+ D LL++GA + ATEDG TP+ VA + G+ +
Sbjct: 123 INAQ-SQNGFTPLYMAAQENHID-VVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
+LLE+ D K ++ L +A R D + DH + S ++
Sbjct: 181 ILLEN--DTKGKVRL---------PALHIAARK--DDTKSAALLLQNDHNADVQSKMMVN 227
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
E G + LH A + V L+ GA V T N T H + G
Sbjct: 228 RTTESGFTPLHIAAHY---------GNVNVATLLLNRGAAVDF-TARNGITPLHVASKRG 277
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
N +++ ++ D ++ + G TPL A GH Q+V LL A +
Sbjct: 278 NTNMVKLLL------DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 331
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM 1021
G S LH+AA+ +++ LL +KA ++ + TALH+AA G+ + K L+ D A
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLL-DKRAN 390
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
+ L TPLH+A +I+V +LL++ GA+I A E G PIH AA + +V L
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
LQ + + + G T H+AA G V+V+ L+ R G + + TPL +A+
Sbjct: 451 LQNGASPDVTNIR-GETALHMAARAGQVEVVRCLL---RNGALVDARAREEQTPLHIASR 506
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTP 1201
G ++V++L++ A G T +H++A G +V V+ + K G TP
Sbjct: 507 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 566
Query: 1202 LHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVR 1261
LH+AA YG + + LL ++ A + ++GLTPLH+AA+ N+ V
Sbjct: 567 LHVAAKYGSLDVAKLLLQR-----RAAADS--------AGKNGLTPLHVAAHYDNQKVAL 613
Query: 1262 LLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIAS 1321
LLL + A+ +NGY PLH+A M I LL+ AE + + G T LH+AS
Sbjct: 614 LLLEKGA--SPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE-TNIVTKQGVTPLHLAS 670
Query: 1322 THGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCA 1381
GH MV +LL +GA I+ + K+G T LH AA+ +NV +L + GA + T L
Sbjct: 671 QEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 730
Query: 1382 PIWFAASENHNDVLEYLL 1399
P+ A + ++ +LL
Sbjct: 731 PLIVACHYGNVKMVNFLL 748
Score = 294 bits (721), Expect = 3e-78
Identities = 240/796 (30%), Positives = 378/796 (47%), Gaps = 57/796 (7%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K D S AAR G++ + L+ G ++ + ALH+A + +V+ LLG
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
G+ V K+ T LHIA+ + + +L+K GA N +++G TP+++AA+ ++
Sbjct: 87 GSSVD-SATKKGNTALHIAS-LAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHID 144
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LLE+G + T+ G TPL +A + V L+E D KG+ A
Sbjct: 145 VVKYLLENGANQSTATE-------DGFTPLAVALQQGHNQAVAILLE--NDTKGKVRLPA 195
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
A +D + A + + + + +V E+G T H A
Sbjct: 196 LHIAARKDDTKS---AALLLQNDHNADVQSKMMVNRTTESGF-----------TPLHIAA 241
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVF 958
GN +V T ++ + D + A N G TPL +A RG+ +V LL ++D
Sbjct: 242 HYGNVNVATLLLNRGAAVDFT-ARN-----GITPLHVASKRGNTNMVKLLLDRGGQIDAK 295
Query: 959 DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH 1018
+G + LH AA G+ QV + LL A + ++ +NG + LH+AA + VK L++ H
Sbjct: 296 TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ-H 354
Query: 1019 NAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVV 1078
A +D +TL T LH+AA G V KLLL+ AN +A G P+H A + N +V+
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVM 414
Query: 1079 QLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQL 1138
+L L ++ + A T+ G T H+AA G + ++ L+ + G + T L +
Sbjct: 415 EL-LVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLL---QNGASPDVTNIRGETALHM 470
Query: 1139 AAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLG 1198
AA G +VVR L+R GA R T +H+A+ G T ++ ++ ++ G
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 530
Query: 1199 LTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNEN 1258
TPLHI+A GQ + LL G S L + G TPLH+AA G+ +
Sbjct: 531 YTPLHISAREGQVDVASVLLE--AGAAHS-----------LATKKGFTPLHVAAKYGSLD 577
Query: 1259 VVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH 1318
V +LLL AD+A +NG PLH+A + + LLL + A H+T ++G T LH
Sbjct: 578 VAKLLLQRRAA-ADSA-GKNGLTPLHVAAHYDNQKVALLLLEKGAS-PHATAKNGYTPLH 634
Query: 1319 IASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNL 1378
IA+ Q+ LL GAE N K G TPLH A++ GH ++V LL + GA+ T
Sbjct: 635 IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 694
Query: 1379 NCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSP 1438
+ AA E+ +V + L D + + Y ++ + ++ N+ + F+L
Sbjct: 695 GLTSLHLAAQEDKVNVADILTKHGADQDA---HTKLGYTPLIVACHYGNVKMVNFLLKQG 751
Query: 1439 APVDTAAKLSNIYINL 1454
A V+ AK N Y L
Sbjct: 752 ANVN--AKTKNGYTPL 765
Score = 293 bits (719), Expect = 4e-78
Identities = 224/724 (30%), Positives = 361/724 (49%), Gaps = 70/724 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++ AA+ H+ ++ LL+ G + T D +T L +A++ V LL
Sbjct: 129 NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK 188
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALML-------LKSGAGPNKATEDGMTPVHVAAKF 774
GK R LHIAAR D AL+L ++S N+ TE G TP+H+AA +
Sbjct: 189 -----GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 243
Query: 775 GNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGES 834
GN+ LLL G + G TPL +A + ++V+ L+ D G+
Sbjct: 244 GNVNVATLLLNRGA-------AVDFTARNGITPLHVASKRGNTNMVKLLL----DRGGQ- 291
Query: 835 VSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAF 894
IDA DG + LH A + + QVV+ L+E GA + +T+ N +
Sbjct: 292 -----IDAKTRDGLTPLHCAAR---------SGHDQVVELLLERGAPLLARTK-NGLSPL 336
Query: 895 HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
H A + + + ++ H + D L+ T L +A H GH ++ LL A
Sbjct: 337 HMAAQGDHVECVKHLLQHKAPVD-DVTLDYL-----TALHVAAHCGHYRVTKLLLDKRAN 390
Query: 955 VDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
+ + G + LH+A + ++V + L+ A I + +G T +H+AA G+ ++V L
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Query: 1015 IRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNY 1074
+++ A DV ++ +T LH+AA +GQ+EV + LL GA +DA Q P+H A++
Sbjct: 451 LQN-GASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGK 509
Query: 1075 SEVVQLFLQQ--HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLND 1132
+E+VQL LQ HP+ A T +G T HI+A +G V V L++ ++ +
Sbjct: 510 TEIVQLLLQHMAHPD---AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF-- 564
Query: 1133 STPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
TPL +AA+ G DV ++L++ A+ + GLT +H+AA + + V ++
Sbjct: 565 -TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 623
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPLHIAA Q + LL++ A T + + G+TPLHLA+
Sbjct: 624 ATAKNGYTPLHIAAKKNQMQIASTLLNY-------GAETNIV------TKQGVTPLHLAS 670
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
G+ ++V LLL+ G S ++G LHLA +++ +L A+ T +
Sbjct: 671 QEGHTDMVTLLLDK-GANIHM-STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHT-KL 727
Query: 1313 GKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASP 1372
G T L +A +G+ +MV LL QGA +NA KNG+TPLH AA+ GH +++ +L + GA P
Sbjct: 728 GYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787
Query: 1373 KSET 1376
+ T
Sbjct: 788 NATT 791
Score = 256 bits (626), Expect = 8e-67
Identities = 211/685 (30%), Positives = 322/685 (47%), Gaps = 64/685 (9%)
Query: 666 SIHTAARYGHVGIINTLLQKGESVDV--------TTNDNYTALHIAVESCKPAVVETLLG 717
++H AAR LLQ + DV TT +T LHIA V LL
Sbjct: 195 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 254
Query: 718 YGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
GA V + TPLH+A++ + + L+L + G K T DG+TP+H AA+ G+
Sbjct: 255 RGAAVDFTA-RNGITPLHVASKRGNTNMVKLLLDRGGQIDAK-TRDGLTPLHCAARSGHD 312
Query: 778 ATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVST 837
+ LLLE G L +TK G +PL MA + + V+HL++ HK
Sbjct: 313 QVVELLLERGAPLLARTK-------NGLSPLHMAAQGDHVECVKHLLQ----HK------ 355
Query: 838 AFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYC 897
A +D V D +ALH A +V K L++ A+ + + N T H
Sbjct: 356 APVDDVTLDYLTALHVAAHC---------GHYRVTKLLLDKRANPNARAL-NGFTPLHIA 405
Query: 898 AIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
VM ++ + ++ G TP+ +A GH+ +V LL N A DV
Sbjct: 406 CKKNRIKVMELLVKY------GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 958 FDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRD 1017
++ G +ALH+AA G ++V LL N A ++++AR +T LH+A+ G +V+ L++
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ- 518
Query: 1018 HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEV 1077
H A D T TPLH++A GQ++V +LLE GA + G P+H AA+ +V
Sbjct: 519 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 578
Query: 1078 VQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
+L LQ+ + K+G T H+AA + KV L++ + +A+ N TPL
Sbjct: 579 AKLLLQRRA-AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK---NGYTPLH 634
Query: 1138 LAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKL 1197
+AA+ + L+ GA + G+T +HLA++ GHT+++ ++ S K
Sbjct: 635 IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 694
Query: 1198 GLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNE 1257
GLT LH+AA + L H +A T + G TPL +A + GN
Sbjct: 695 GLTSLHLAAQEDKVNVADILTKH---GADQDAHT----------KLGYTPLIVACHYGNV 741
Query: 1258 NVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGL 1317
+V LL G + A +NGY PLH A GH I+ +LL A+ ++T +G T L
Sbjct: 742 KMVNFLLKQ-GANVN-AKTKNGYTPLHQAAQQGHTHIINVLLQHGAK-PNATTANGNTAL 798
Query: 1318 HIASTHGHYQMVEVLLGQGAEINAT 1342
IA G+ +V+ L E+ T
Sbjct: 799 AIAKRLGYISVVDTLKVVTEEVTTT 823
Score = 89.0 bits (211), Expect = 2e-16
Identities = 46/134 (34%), Positives = 75/134 (55%), Gaps = 1/134 (0%)
Query: 86 QTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEP 145
Q+ + TT +G T LH+AA +V++A +L++ GA VD T G TPLH+A+ G+
Sbjct: 221 QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTN 280
Query: 146 LVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIA 205
+VK + TP+H AA +GH ++ELL ++ A + RTK+G + +H+A
Sbjct: 281 MVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER-GAPLLARTKNGLSPLHMA 339
Query: 206 SLNGHADCAMMLFK 219
+ H +C L +
Sbjct: 340 AQGDHVECVKHLLQ 353
Score = 86.6 bits (205), Expect = 8e-16
Identities = 54/173 (31%), Positives = 79/173 (45%), Gaps = 3/173 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D G PL ++ G + LL A A L T G T LH+AA+ +D+A++
Sbjct: 524 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL--ATKKGFTPLHVAAKYGSLDVAKL 581
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+ A D+ G TPLH+AA ++ + A+ TP+H+AA+
Sbjct: 582 LLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQ 641
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
I L + + A TK G T +H+AS GH D +L KG +HM K
Sbjct: 642 MQIASTLLN-YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTK 693
Score = 84.2 bits (199), Expect = 4e-15
Identities = 53/162 (32%), Positives = 82/162 (50%), Gaps = 3/162 (1%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
+ + G P+ +A G+ ++V LL Q T G+TALH+AAR V++ R L+
Sbjct: 427 ITESGLTPIHVAAFMGHLNIV--LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLL 484
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
GA+VDA QTPLHIA+ G +V+ A+ A TP+H++A G
Sbjct: 485 RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVD 544
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+ +L + A TK G T +H+A+ G D A +L ++
Sbjct: 545 VASVLLEAGAAHSL-ATKKGFTPLHVAAKYGSLDVAKLLLQR 585
Score = 83.4 bits (197), Expect = 8e-15
Identities = 54/164 (32%), Positives = 82/164 (50%), Gaps = 3/164 (1%)
Query: 58 LVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARIL 117
L ++G PL +A + G+ + + LL + A G T LH+AA + +A +L
Sbjct: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN--GLTPLHVAAHYDNQKVALLL 615
Query: 118 VDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
++ GA AT G TPLHIAA + + A I + TP+HLA++ GH
Sbjct: 616 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 675
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
++ LL DK A+I TK G T +H+A+ + A +L K G
Sbjct: 676 DMVTLLLDK-GANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG 718
Score = 79.0 bits (186), Expect = 2e-13
Identities = 53/154 (34%), Positives = 79/154 (51%), Gaps = 3/154 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
++V ++G PL LA + G+ MV LL + +T +G T+LHLAA+ V++A I
Sbjct: 656 NIVTKQGVTPLHLASQEGHTDMVTLLLDK--GANIHMSTKSGLTSLHLAAQEDKVNVADI 713
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L +GA DA G TPL +A G+ +V + AN TP+H AA+ GH
Sbjct: 714 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 773
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
II +L + A T +G+T + IA G+
Sbjct: 774 THIINVLL-QHGAKPNATTANGNTALAIAKRLGY 806
Score = 77.8 bits (183), Expect = 4e-13
Identities = 55/166 (33%), Positives = 77/166 (46%), Gaps = 3/166 (1%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL +A G +V+ LL Q A T G T LH++AR VD+A +L++ GA
Sbjct: 498 QTPLHIASRLGKTEIVQLLL--QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
G TPLH+AA G + K RA A A TP+H+AA + + LL
Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+K AS K+G T +HIA+ A L G ++ K
Sbjct: 616 LEK-GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 660
Score = 75.8 bits (178), Expect = 2e-12
Identities = 52/159 (32%), Positives = 83/159 (52%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL +A + N+ V ELL A ++A T +G T +H+AA +++ +L+ GA
Sbjct: 398 GFTPLHIACKK-NRIKVMELLVKYGAS-IQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 455
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
D TN G+T LH+AA G +V+ A E++TP+H+A+ G I++L
Sbjct: 456 SPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 515
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L + A T +G T +HI++ G D A +L + G
Sbjct: 516 LL-QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 553
Score = 73.3 bits (172), Expect = 8e-12
Identities = 52/170 (30%), Positives = 86/170 (50%), Gaps = 15/170 (8%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV--DY 120
G PL +A++ G+ V LL T +++ ALH+AAR+ D A +L+ D+
Sbjct: 163 GFTPLAVALQQGHNQAVAILLENDTKGKVRLP------ALHIAARKDDTKSAALLLQNDH 216
Query: 121 GA------VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAEN 174
A +V+ T +G TPLHIAA G+ + A TP+H+A++
Sbjct: 217 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR 276
Query: 175 GHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
G+ +++LL D+ I +T+DG T +H A+ +GH +L ++G L
Sbjct: 277 GNTNMVKLLLDR-GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
Score = 72.9 bits (171), Expect = 1e-11
Identities = 54/165 (32%), Positives = 79/165 (47%), Gaps = 3/165 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D + G PL +A + GN +MV+ LL Q+ A T G T LH AAR + +
Sbjct: 260 DFTARNGITPLHVASKRGNTNMVKLLLDR--GGQIDAKTRDGLTPLHCAARSGHDQVVEL 317
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L++ GA + A G +PLH+AA VK+ +A + T +H+AA GH
Sbjct: 318 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGH 377
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ +LL DK +A+ R +G T +HIA +L K G
Sbjct: 378 YRVTKLLLDK-RANPNARALNGFTPLHIACKKNRIKVMELLVKYG 421
Score = 71.7 bits (168), Expect = 3e-11
Identities = 41/125 (32%), Positives = 70/125 (56%), Gaps = 2/125 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
Q G L LA + G+ +V+ELL ++ + + T G+TALH+A+ ++ ++LV
Sbjct: 62 QNGLNALHLAAKEGHVGLVQELLGRGSS--VDSATKKGNTALHIASLAGQAEVVKVLVKE 119
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA ++A + G TPL++AA E +VKY AN + A + TP+ +A + GH +
Sbjct: 120 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAV 179
Query: 181 ELLAD 185
+L +
Sbjct: 180 AILLE 184
Score = 64.1 bits (149), Expect = 5e-09
Identities = 47/161 (29%), Positives = 74/161 (45%), Gaps = 3/161 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A + NQ + L AE T G T LHLA++ DM +L+D
Sbjct: 627 KNGYTPLHIAAKK-NQMQIASTLLNYGAET-NIVTKQGVTPLHLASQEGHTDMVTLLLDK 684
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA + + +G T LH+AA E + A+ TP+ +A G+ ++
Sbjct: 685 GANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMV 744
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L K A++ +TK+G T +H A+ GH +L + G
Sbjct: 745 NFLL-KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHG 784
Score = 54.4 bits (125), Expect = 4e-06
Identities = 46/161 (28%), Positives = 71/161 (44%), Gaps = 3/161 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A + + V+ LL Q + T TALH+AA + ++L+D
Sbjct: 330 KNGLSPLHMAAQGDHVECVKHLL--QHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDK 387
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A +A G TPLHIA + +++ A+ TP+H+AA GH I+
Sbjct: 388 RANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIV 447
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LL AS G T +H+A+ G + L + G
Sbjct: 448 LLLLQN-GASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 487
Score = 53.2 bits (122), Expect = 1e-05
Identities = 33/117 (28%), Positives = 60/117 (51%), Gaps = 1/117 (0%)
Query: 105 AARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED 164
AAR ++D + G ++ N G LH+AA EG LV+ G ++ A +
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 165 RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
T +H+A+ G A ++++L K A+I ++++G T +++A+ H D L + G
Sbjct: 98 NTALHIASLAGQAEVVKVLV-KEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
Score = 49.6 bits (113), Expect = 1e-04
Identities = 36/130 (27%), Positives = 64/130 (49%), Gaps = 9/130 (6%)
Query: 135 LHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFER 194
L A A + +V+Y G + + +HLAA+ GH +++ L + +S+
Sbjct: 36 LRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLGR-GSSVDSA 93
Query: 195 TKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK------YFEKQ-TFDEVLFVKIENG 247
TK G+T +HIASL G A+ +L K+G ++ ++ Y Q +V+ +ENG
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
Query: 248 LIKGLKSDDG 257
+ ++DG
Sbjct: 154 ANQSTATEDG 163
Score = 42.7 bits (96), Expect = 0.014
Identities = 24/54 (44%), Positives = 31/54 (57%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETL 715
+G +H AA+ GH IIN LLQ G + TT + TAL IA +VV+TL
Sbjct: 760 NGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
>BX537758-1|CAD97827.1| 1863|Homo sapiens hypothetical protein
protein.
Length = 1863
Score = 313 bits (768), Expect = 5e-84
Identities = 232/738 (31%), Positives = 361/738 (48%), Gaps = 52/738 (7%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H AA+ GHVG++ LL +G SVD T TALHIA + + VV+ L+ GA+
Sbjct: 42 NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGAN 101
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
++ + + TPL++AA+ D LL++GA + ATEDG TP+ VA + G+ +
Sbjct: 102 INAQ-SQNGFTPLYMAAQENHID-VVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 159
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
+LLE+ D K ++ L +A R D + DH + S ++
Sbjct: 160 ILLEN--DTKGKVRL---------PALHIAARK--DDTKSAALLLQNDHNADIQSKMMVN 206
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
E G + LH A + V L+ GA V T N T H + G
Sbjct: 207 RTTESGFTPLHIAAHY---------GNVNVATLLLNRGAAVDF-TARNGITPLHVASKRG 256
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
N +++ ++ D ++ + G TPL A GH Q+V LL A +
Sbjct: 257 NTNMVKLLL------DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 310
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM 1021
G S LH+AA+ +++ LL +KA ++ + TALH+AA G+ + K L+ D A
Sbjct: 311 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLL-DKRAN 369
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
+ L TPLH+A +I+V +LL++ GA+I A E G PIH AA + +V L
Sbjct: 370 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 429
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
LQ + + + G T H+AA G V+V+ L+ R G + + TPL +A+
Sbjct: 430 LQNGASPDVTNIR-GETALHMAARAGQVEVVRCLL---RNGALVDARAREEQTPLHIASR 485
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTP 1201
G ++V++L++ A G T +H++A G +V V+ + K G TP
Sbjct: 486 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 545
Query: 1202 LHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVR 1261
LH+AA YG + + LL ++ A + ++GLTPLH+AA+ N+ V
Sbjct: 546 LHVAAKYGSLDVAKLLLQR-----RAAADS--------AGKNGLTPLHVAAHYDNQKVAL 592
Query: 1262 LLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIAS 1321
LLL + A+ +NGY PLH+A M I LL+ AE + + G T LH+AS
Sbjct: 593 LLLEKGA--SPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE-TNIVTKQGVTPLHLAS 649
Query: 1322 THGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCA 1381
GH MV +LL +GA I+ + K+G T LH AA+ +NV +L + GA + T L
Sbjct: 650 QEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 709
Query: 1382 PIWFAASENHNDVLEYLL 1399
P+ A + ++ +LL
Sbjct: 710 PLIVACHYGNVKMVNFLL 727
Score = 293 bits (720), Expect = 3e-78
Identities = 224/724 (30%), Positives = 361/724 (49%), Gaps = 70/724 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++ AA+ H+ ++ LL+ G + T D +T L +A++ V LL
Sbjct: 108 NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK 167
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALML-------LKSGAGPNKATEDGMTPVHVAAKF 774
GK R LHIAAR D AL+L ++S N+ TE G TP+H+AA +
Sbjct: 168 -----GKVRLPALHIAARKDDTKSAALLLQNDHNADIQSKMMVNRTTESGFTPLHIAAHY 222
Query: 775 GNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGES 834
GN+ LLL G + G TPL +A + ++V+ L+ D G+
Sbjct: 223 GNVNVATLLLNRGA-------AVDFTARNGITPLHVASKRGNTNMVKLLL----DRGGQ- 270
Query: 835 VSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAF 894
IDA DG + LH A + + QVV+ L+E GA + +T+ N +
Sbjct: 271 -----IDAKTRDGLTPLHCAAR---------SGHDQVVELLLERGAPLLARTK-NGLSPL 315
Query: 895 HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
H A + + + ++ H + D L+ T L +A H GH ++ LL A
Sbjct: 316 HMAAQGDHVECVKHLLQHKAPVD-DVTLDYL-----TALHVAAHCGHYRVTKLLLDKRAN 369
Query: 955 VDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
+ + G + LH+A + ++V + L+ A I + +G T +H+AA G+ ++V L
Sbjct: 370 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 429
Query: 1015 IRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNY 1074
+++ A DV ++ +T LH+AA +GQ+EV + LL GA +DA Q P+H A++
Sbjct: 430 LQN-GASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGK 488
Query: 1075 SEVVQLFLQQ--HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLND 1132
+E+VQL LQ HP+ A T +G T HI+A +G V V L++ ++ +
Sbjct: 489 TEIVQLLLQHMAHPD---AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF-- 543
Query: 1133 STPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
TPL +AA+ G DV ++L++ A+ + GLT +H+AA + + V ++
Sbjct: 544 -TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 602
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPLHIAA Q + LL++ A T + + G+TPLHLA+
Sbjct: 603 ATAKNGYTPLHIAAKKNQMQIASTLLNY-------GAETNIV------TKQGVTPLHLAS 649
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
G+ ++V LLL+ G S ++G LHLA +++ +L A+ T +
Sbjct: 650 QEGHTDMVTLLLDK-GANIHM-STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHT-KL 706
Query: 1313 GKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASP 1372
G T L +A +G+ +MV LL QGA +NA KNG+TPLH AA+ GH +++ +L + GA P
Sbjct: 707 GYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 766
Query: 1373 KSET 1376
+ T
Sbjct: 767 NATT 770
Score = 293 bits (718), Expect = 6e-78
Identities = 239/793 (30%), Positives = 377/793 (47%), Gaps = 57/793 (7%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
D S AAR G++ + L+ G ++ + ALH+A + +V+ LLG G+
Sbjct: 9 DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 68
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V K+ T LHIA+ + + +L+K GA N +++G TP+++AA+ ++ +
Sbjct: 69 VD-SATKKGNTALHIAS-LAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK 126
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LLE+G + T+ G TPL +A + V L+E D KG+ A
Sbjct: 127 YLLENGANQSTATE-------DGFTPLAVALQQGHNQAVAILLE--NDTKGKVRLPALHI 177
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
A +D + A + + + + +V E+G T H A G
Sbjct: 178 AARKDDTKS---AALLLQNDHNADIQSKMMVNRTTESGF-----------TPLHIAAHYG 223
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
N +V T ++ + D + A N G TPL +A RG+ +V LL ++D +
Sbjct: 224 NVNVATLLLNRGAAVDFT-ARN-----GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 277
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM 1021
G + LH AA G+ QV + LL A + ++ +NG + LH+AA + VK L++ H A
Sbjct: 278 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ-HKAP 336
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
+D +TL T LH+AA G V KLLL+ AN +A G P+H A + N +V++L
Sbjct: 337 VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMEL- 395
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L ++ + A T+ G T H+AA G + ++ L+ + G + T L +AA
Sbjct: 396 LVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLL---QNGASPDVTNIRGETALHMAAR 452
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTP 1201
G +VVR L+R GA R T +H+A+ G T ++ ++ ++ G TP
Sbjct: 453 AGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTP 512
Query: 1202 LHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVR 1261
LHI+A GQ + LL G S L + G TPLH+AA G+ +V +
Sbjct: 513 LHISAREGQVDVASVLLE--AGAAHS-----------LATKKGFTPLHVAAKYGSLDVAK 559
Query: 1262 LLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIAS 1321
LLL AD+A +NG PLH+A + + LLL + A H+T ++G T LHIA+
Sbjct: 560 LLLQRRAA-ADSA-GKNGLTPLHVAAHYDNQKVALLLLEKGAS-PHATAKNGYTPLHIAA 616
Query: 1322 THGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCA 1381
Q+ LL GAE N K G TPLH A++ GH ++V LL + GA+ T
Sbjct: 617 KKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLT 676
Query: 1382 PIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPV 1441
+ AA E+ +V + L D + + Y ++ + ++ N+ + F+L A V
Sbjct: 677 SLHLAAQEDKVNVADILTKHGADQDA---HTKLGYTPLIVACHYGNVKMVNFLLKQGANV 733
Query: 1442 DTAAKLSNIYINL 1454
+ AK N Y L
Sbjct: 734 N--AKTKNGYTPL 744
Score = 255 bits (625), Expect = 1e-66
Identities = 210/685 (30%), Positives = 322/685 (47%), Gaps = 64/685 (9%)
Query: 666 SIHTAARYGHVGIINTLLQKGESVDV--------TTNDNYTALHIAVESCKPAVVETLLG 717
++H AAR LLQ + D+ TT +T LHIA V LL
Sbjct: 174 ALHIAARKDDTKSAALLLQNDHNADIQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 233
Query: 718 YGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
GA V + TPLH+A++ + + L+L + G K T DG+TP+H AA+ G+
Sbjct: 234 RGAAVDFTA-RNGITPLHVASKRGNTNMVKLLLDRGGQIDAK-TRDGLTPLHCAARSGHD 291
Query: 778 ATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVST 837
+ LLLE G L +TK G +PL MA + + V+HL++ HK
Sbjct: 292 QVVELLLERGAPLLARTK-------NGLSPLHMAAQGDHVECVKHLLQ----HK------ 334
Query: 838 AFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYC 897
A +D V D +ALH A +V K L++ A+ + + N T H
Sbjct: 335 APVDDVTLDYLTALHVAAHC---------GHYRVTKLLLDKRANPNARAL-NGFTPLHIA 384
Query: 898 AIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
VM ++ + ++ G TP+ +A GH+ +V LL N A DV
Sbjct: 385 CKKNRIKVMELLVKY------GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 438
Query: 958 FDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRD 1017
++ G +ALH+AA G ++V LL N A ++++AR +T LH+A+ G +V+ L++
Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ- 497
Query: 1018 HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEV 1077
H A D T TPLH++A GQ++V +LLE GA + G P+H AA+ +V
Sbjct: 498 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 557
Query: 1078 VQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
+L LQ+ + K+G T H+AA + KV L++ + +A+ N TPL
Sbjct: 558 AKLLLQRRA-AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK---NGYTPLH 613
Query: 1138 LAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKL 1197
+AA+ + L+ GA + G+T +HLA++ GHT+++ ++ S K
Sbjct: 614 IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 673
Query: 1198 GLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNE 1257
GLT LH+AA + L H +A T + G TPL +A + GN
Sbjct: 674 GLTSLHLAAQEDKVNVADILTKH---GADQDAHT----------KLGYTPLIVACHYGNV 720
Query: 1258 NVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGL 1317
+V LL G + A +NGY PLH A GH I+ +LL A+ ++T +G T L
Sbjct: 721 KMVNFLLKQ-GANVN-AKTKNGYTPLHQAAQQGHTHIINVLLQHGAK-PNATTANGNTAL 777
Query: 1318 HIASTHGHYQMVEVLLGQGAEINAT 1342
IA G+ +V+ L E+ T
Sbjct: 778 AIAKRLGYISVVDTLKVVTEEVTTT 802
Score = 89.0 bits (211), Expect = 2e-16
Identities = 46/134 (34%), Positives = 75/134 (55%), Gaps = 1/134 (0%)
Query: 86 QTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEP 145
Q+ + TT +G T LH+AA +V++A +L++ GA VD T G TPLH+A+ G+
Sbjct: 200 QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTN 259
Query: 146 LVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIA 205
+VK + TP+H AA +GH ++ELL ++ A + RTK+G + +H+A
Sbjct: 260 MVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER-GAPLLARTKNGLSPLHMA 318
Query: 206 SLNGHADCAMMLFK 219
+ H +C L +
Sbjct: 319 AQGDHVECVKHLLQ 332
Score = 86.6 bits (205), Expect = 8e-16
Identities = 54/173 (31%), Positives = 79/173 (45%), Gaps = 3/173 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D G PL ++ G + LL A A L T G T LH+AA+ +D+A++
Sbjct: 503 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL--ATKKGFTPLHVAAKYGSLDVAKL 560
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+ A D+ G TPLH+AA ++ + A+ TP+H+AA+
Sbjct: 561 LLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQ 620
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
I L + + A TK G T +H+AS GH D +L KG +HM K
Sbjct: 621 MQIASTLLN-YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTK 672
Score = 84.2 bits (199), Expect = 4e-15
Identities = 53/162 (32%), Positives = 82/162 (50%), Gaps = 3/162 (1%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
+ + G P+ +A G+ ++V LL Q T G+TALH+AAR V++ R L+
Sbjct: 406 ITESGLTPIHVAAFMGHLNIV--LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLL 463
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
GA+VDA QTPLHIA+ G +V+ A+ A TP+H++A G
Sbjct: 464 RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVD 523
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+ +L + A TK G T +H+A+ G D A +L ++
Sbjct: 524 VASVLLEAGAAHSL-ATKKGFTPLHVAAKYGSLDVAKLLLQR 564
Score = 83.4 bits (197), Expect = 8e-15
Identities = 54/164 (32%), Positives = 82/164 (50%), Gaps = 3/164 (1%)
Query: 58 LVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARIL 117
L ++G PL +A + G+ + + LL + A G T LH+AA + +A +L
Sbjct: 537 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN--GLTPLHVAAHYDNQKVALLL 594
Query: 118 VDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
++ GA AT G TPLHIAA + + A I + TP+HLA++ GH
Sbjct: 595 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 654
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
++ LL DK A+I TK G T +H+A+ + A +L K G
Sbjct: 655 DMVTLLLDK-GANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG 697
Score = 79.0 bits (186), Expect = 2e-13
Identities = 53/154 (34%), Positives = 79/154 (51%), Gaps = 3/154 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
++V ++G PL LA + G+ MV LL + +T +G T+LHLAA+ V++A I
Sbjct: 635 NIVTKQGVTPLHLASQEGHTDMVTLLLDK--GANIHMSTKSGLTSLHLAAQEDKVNVADI 692
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L +GA DA G TPL +A G+ +V + AN TP+H AA+ GH
Sbjct: 693 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 752
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
II +L + A T +G+T + IA G+
Sbjct: 753 THIINVLL-QHGAKPNATTANGNTALAIAKRLGY 785
Score = 77.8 bits (183), Expect = 4e-13
Identities = 55/166 (33%), Positives = 77/166 (46%), Gaps = 3/166 (1%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL +A G +V+ LL Q A T G T LH++AR VD+A +L++ GA
Sbjct: 477 QTPLHIASRLGKTEIVQLLL--QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 534
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
G TPLH+AA G + K RA A A TP+H+AA + + LL
Sbjct: 535 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 594
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+K AS K+G T +HIA+ A L G ++ K
Sbjct: 595 LEK-GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 639
Score = 75.8 bits (178), Expect = 2e-12
Identities = 52/159 (32%), Positives = 83/159 (52%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL +A + N+ V ELL A ++A T +G T +H+AA +++ +L+ GA
Sbjct: 377 GFTPLHIACKK-NRIKVMELLVKYGAS-IQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 434
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
D TN G+T LH+AA G +V+ A E++TP+H+A+ G I++L
Sbjct: 435 SPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 494
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L + A T +G T +HI++ G D A +L + G
Sbjct: 495 LL-QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 532
Score = 73.3 bits (172), Expect = 8e-12
Identities = 52/170 (30%), Positives = 86/170 (50%), Gaps = 15/170 (8%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV--DY 120
G PL +A++ G+ V LL T +++ ALH+AAR+ D A +L+ D+
Sbjct: 142 GFTPLAVALQQGHNQAVAILLENDTKGKVRLP------ALHIAARKDDTKSAALLLQNDH 195
Query: 121 GA------VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAEN 174
A +V+ T +G TPLHIAA G+ + A TP+H+A++
Sbjct: 196 NADIQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR 255
Query: 175 GHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
G+ +++LL D+ I +T+DG T +H A+ +GH +L ++G L
Sbjct: 256 GNTNMVKLLLDR-GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 304
Score = 72.9 bits (171), Expect = 1e-11
Identities = 54/165 (32%), Positives = 79/165 (47%), Gaps = 3/165 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D + G PL +A + GN +MV+ LL Q+ A T G T LH AAR + +
Sbjct: 239 DFTARNGITPLHVASKRGNTNMVKLLLDR--GGQIDAKTRDGLTPLHCAARSGHDQVVEL 296
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L++ GA + A G +PLH+AA VK+ +A + T +H+AA GH
Sbjct: 297 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGH 356
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ +LL DK +A+ R +G T +HIA +L K G
Sbjct: 357 YRVTKLLLDK-RANPNARALNGFTPLHIACKKNRIKVMELLVKYG 400
Score = 71.7 bits (168), Expect = 3e-11
Identities = 41/125 (32%), Positives = 70/125 (56%), Gaps = 2/125 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
Q G L LA + G+ +V+ELL ++ + + T G+TALH+A+ ++ ++LV
Sbjct: 41 QNGLNALHLAAKEGHVGLVQELLGRGSS--VDSATKKGNTALHIASLAGQAEVVKVLVKE 98
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA ++A + G TPL++AA E +VKY AN + A + TP+ +A + GH +
Sbjct: 99 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAV 158
Query: 181 ELLAD 185
+L +
Sbjct: 159 AILLE 163
Score = 64.1 bits (149), Expect = 5e-09
Identities = 47/161 (29%), Positives = 74/161 (45%), Gaps = 3/161 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A + NQ + L AE T G T LHLA++ DM +L+D
Sbjct: 606 KNGYTPLHIAAKK-NQMQIASTLLNYGAET-NIVTKQGVTPLHLASQEGHTDMVTLLLDK 663
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA + + +G T LH+AA E + A+ TP+ +A G+ ++
Sbjct: 664 GANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMV 723
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L K A++ +TK+G T +H A+ GH +L + G
Sbjct: 724 NFLL-KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHG 763
Score = 54.4 bits (125), Expect = 4e-06
Identities = 46/161 (28%), Positives = 71/161 (44%), Gaps = 3/161 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A + + V+ LL Q + T TALH+AA + ++L+D
Sbjct: 309 KNGLSPLHMAAQGDHVECVKHLL--QHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDK 366
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A +A G TPLHIA + +++ A+ TP+H+AA GH I+
Sbjct: 367 RANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIV 426
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LL AS G T +H+A+ G + L + G
Sbjct: 427 LLLLQN-GASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 466
Score = 53.2 bits (122), Expect = 1e-05
Identities = 33/117 (28%), Positives = 60/117 (51%), Gaps = 1/117 (0%)
Query: 105 AARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED 164
AAR ++D + G ++ N G LH+AA EG LV+ G ++ A +
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 165 RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
T +H+A+ G A ++++L K A+I ++++G T +++A+ H D L + G
Sbjct: 77 NTALHIASLAGQAEVVKVLV-KEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132
Score = 49.6 bits (113), Expect = 1e-04
Identities = 36/130 (27%), Positives = 64/130 (49%), Gaps = 9/130 (6%)
Query: 135 LHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFER 194
L A A + +V+Y G + + +HLAA+ GH +++ L + +S+
Sbjct: 15 LRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLGR-GSSVDSA 72
Query: 195 TKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK------YFEKQ-TFDEVLFVKIENG 247
TK G+T +HIASL G A+ +L K+G ++ ++ Y Q +V+ +ENG
Sbjct: 73 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132
Query: 248 LIKGLKSDDG 257
+ ++DG
Sbjct: 133 ANQSTATEDG 142
Score = 42.7 bits (96), Expect = 0.014
Identities = 24/54 (44%), Positives = 31/54 (57%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETL 715
+G +H AA+ GH IIN LLQ G + TT + TAL IA +VV+TL
Sbjct: 739 NGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
>X16609-2|CAA34611.1| 1719|Homo sapiens alt. ankyrin (variant 2.2)
protein.
Length = 1719
Score = 308 bits (757), Expect = 1e-82
Identities = 232/752 (30%), Positives = 382/752 (50%), Gaps = 63/752 (8%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA+ H+ ++ LL+ G + +V T D +T L +A++ VV L+ YG
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK- 169
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
GK R LHIAAR D + A +LL++ P+ ++ G TP+H+AA + NL L
Sbjct: 170 ----GKVRLPALHIAAR-NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQL 224
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL G + G TPL +A R +VR L++ +G + T
Sbjct: 225 LLNRGAS-------VNFTPQNGITPLHIASRRGNVIMVRLLLD-----RGAQIETK---- 268
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
+D + LH C V+I + L+++GA + +T+ N + H A +
Sbjct: 269 -TKDELTPLH--CAARNGHVRIS-------EILLDHGAPIQAKTK-NGLSPIHMAAQGDH 317
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
D + ++ + + D L+ TPL +A H GH ++ LL A+ + + G
Sbjct: 318 LDCVRLLLQYDAEID-DITLDHL-----TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+ LH+A + +++V + LL A I++ +G T LH+A+ G+ +VK L++ A
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ-RGASP 430
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
+V +K +TPLH+AA +G EV K LL+ A ++A + Q P+H AA+ ++ +V+L L
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
+ + N +ATT G+T HIAA +G V+ + L++ + + + TPL +AA+
Sbjct: 491 ENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKEASQACMTKKGF---TPLHVAAKY 546
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
G V +L+ A + GLT +H+A H + +++ ++ S G TPL
Sbjct: 547 GKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606
Query: 1203 HIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRL 1262
HIAA Q E R LL + G+ +E+ GV TPLHLAA G+ +V L
Sbjct: 607 HIAAKQNQVEVARSLLQY-GGSANAESVQGV------------TPLHLAAQEGHAEMVAL 653
Query: 1263 LLNSAGVQADA-ASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIAS 1321
LL+ QA+ N++G PLHL GH+ + +L+ ++ +T R G T LH+AS
Sbjct: 654 LLSK---QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV-MVDATTRMGYTPLHVAS 709
Query: 1322 THGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCA 1381
+G+ ++V+ LL A++NA K G++PLH AA+ GH ++V LL ++GASP ++
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769
Query: 1382 PIWFAASENHNDVLEYLLHKEHDTQ-SLMDDK 1412
P+ A + V + L +T L+ DK
Sbjct: 770 PLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801
Score = 297 bits (729), Expect = 3e-79
Identities = 222/743 (29%), Positives = 374/743 (50%), Gaps = 37/743 (4%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G +H A++ GHV ++ LL K ++ TT TALHIA + + VV L+ YGA+
Sbjct: 44 NGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGAN 103
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN---LA 778
V+ + K TPL++AA+ + + LL++GA N ATEDG TP+ VA + G+ +A
Sbjct: 104 VNAQSQK-GFTPLYMAAQ-ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVA 161
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
L+ G L + + T T + PD++ F H
Sbjct: 162 HLINYGTKGKVRLPALHIAARNDDT-RTAAVLLQNDPNPDVLSK-TGFTPLHIAAHYENL 219
Query: 839 FIDAVDEDGASALHYACK--VTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHY 896
+ + + +++++ + +T + + +V+ L++ GA + +T+ + T H
Sbjct: 220 NVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPLH- 277
Query: 897 CAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVD 956
CA + ++E++ D + + G +P+ +A H+ V LL A +D
Sbjct: 278 CAARNGHVRISEIL-----LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Query: 957 VFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIR 1016
++ + LH+AA G+ +V LL A NS+A NG T LH+A + +++ L++
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Query: 1017 DHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSE 1076
A ID +T TPLH+A+ G + + K LL+ GA+ + ++ + P+H AA+ ++E
Sbjct: 393 T-GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTE 451
Query: 1077 VVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPL 1136
V + +L Q+ V A KD T H AA G +++ L++ + ++ TPL
Sbjct: 452 VAK-YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT---TAGHTPL 507
Query: 1137 QLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
+AA GH + V L+ AS + G T +H+AA++G V +++ + ++ K
Sbjct: 508 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567
Query: 1197 LGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGN 1256
GLTPLH+A ++ + V+ LL P G S P A +G TPLH+AA
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLL-----------PRGGS--PHSPAWNGYTPLHIAAKQNQ 614
Query: 1257 ENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTG 1316
V R LL G A+A S + G PLHLA GH +V LLLS+ A + ++ G T
Sbjct: 615 VEVARSLLQYGG-SANAESVQ-GVTPLHLAAQEGHAEMVALLLSKQAN-GNLGNKSGLTP 671
Query: 1317 LHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSET 1376
LH+ + GH + +VL+ G ++AT + G+TPLH A+ G++ +VK L + A ++T
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731
Query: 1377 NLNCAPIWFAASENHNDVLEYLL 1399
L +P+ AA + H D++ LL
Sbjct: 732 KLGYSPLHQAAQQGHTDIVTLLL 754
Score = 276 bits (677), Expect = 5e-73
Identities = 231/790 (29%), Positives = 368/790 (46%), Gaps = 63/790 (7%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
++ D A S AAR G++ L+ G ++ + LH+A + +V LL
Sbjct: 7 FREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL- 65
Query: 718 YGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
+ + K+ T LHIAA + D+ L+ GA N ++ G TP+++AA+ +L
Sbjct: 66 HKEIILETTTKKGNTALHIAA-LAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 778 ATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVST 837
+ LLE+G + T+ G TPL +A + ++V HLI + KG+
Sbjct: 125 EVVKFLLENGANQNVATE-------DGFTPLAVALQQGHENVVAHLINY--GTKGKV--- 172
Query: 838 AFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYC 897
ALH A + D + L++N + + ++ T H
Sbjct: 173 ---------RLPALHIAAR---------NDDTRTAAVLLQNDPNPDVLSKTGF-TPLHIA 213
Query: 898 AIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
A N +V ++ S QN I TPL IA RG++ +V LL A+++
Sbjct: 214 AHYENLNVAQLLL----NRGASVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 958 FDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRD 1017
+ + LH AA +G++++ + LL + A I +K +NG + +H+AA + V+ L++
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ- 326
Query: 1018 HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEV 1077
++A ID +TL TPLH+AA G V K+LL+ GA ++ G P+H A + N+ V
Sbjct: 327 YDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
Query: 1078 VQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
++L L+ + + A T+ G T H+A+ G + +++ L+ + G + + TPL
Sbjct: 387 MELLLKTGAS-IDAVTESGLTPLHVASFMGHLPIVKNLL---QRGASPNVSNVKVETPLH 442
Query: 1138 LAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKL 1197
+AA GH +V + L++ A + + T +H AA GHTN++ ++ N +
Sbjct: 443 MAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA 502
Query: 1198 GLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNE 1257
G TPLHIAA G ETV LL + EA + G TPLH+AA G
Sbjct: 503 GHTPLHIAAREGHVETVLALL-------EKEASQACM------TKKGFTPLHVAAKYGKV 549
Query: 1258 NVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGL 1317
V LLL A+ +NG PLH+A ++ IV LLL R HS +G T L
Sbjct: 550 RVAELLLERDA--HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS-PHSPAWNGYTPL 606
Query: 1318 HIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETN 1377
HIA+ ++ LL G NA G TPLH AA+ GH +V LL A+
Sbjct: 607 HIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK 666
Query: 1378 LNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVS 1437
P+ A E H V + L+ +H + R Y + + ++ NI + +F+L
Sbjct: 667 SGLTPLHLVAQEGHVPVADVLI--KHGVM-VDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 1438 PAPVDTAAKL 1447
A V+ KL
Sbjct: 724 QADVNAKTKL 733
Score = 225 bits (551), Expect = 1e-57
Identities = 185/597 (30%), Positives = 291/597 (48%), Gaps = 39/597 (6%)
Query: 876 IENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLI 935
+ NG D++ N H + G+ ++ E++ H L G T L I
Sbjct: 32 LRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELL-HKEII-----LETTTKKGNTALHI 84
Query: 936 ACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNG 995
A G ++V L+ A V+ +G + L++AA+ +L+V LL N A N +G
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 996 RTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANI 1055
T L +A G+ ++V LI ++ V + LH+AA + +LL+ N
Sbjct: 145 FTPLAVALQQGHENVVAHLI-NYGTKGKV----RLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 1056 DATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEEL 1115
D + G P+H AA V QL L + + V T ++G T HIA+ +G+V ++ L
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS-VNFTPQNGITPLHIASRRGNVIMVRLL 258
Query: 1116 MKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEH 1175
+ DR I + K ++ TPL AA GH + +L+ GA + + GL+ +H+AA+
Sbjct: 259 L--DRGAQIETKTK-DELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 1176 GHTNVLDVMRSTNTLRISSKKLG-LTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVS 1234
H + + ++ + I L LTPLH+AA+ G + LL K P +
Sbjct: 316 DHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHHRVAKVLLD------KGAKPNSRA 368
Query: 1235 LVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSI 1294
L +G TPLH+A + V+ LLL + G DA + E+G PLH+A F GH+ I
Sbjct: 369 L-------NGFTPLHIACKKNHVRVMELLLKT-GASIDAVT-ESGLTPLHVASFMGHLPI 419
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
V LL R A S + +T LH+A+ GH ++ + LL A++NA K+ TPLHCAA
Sbjct: 420 VKNLLQRGASPNVSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRF 1414
+ GH N+VKLL E+ A+P T P+ AA E H + + LL KE +Q+ M K F
Sbjct: 479 RIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE-ASQACMTKKGF 537
Query: 1415 VYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAK--LSNIYINLSTKEKERAKDLIAAG 1469
L V +K + + + E +L A + A K L+ +++ + + K L+ G
Sbjct: 538 T-PLHVAAK-YGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Score = 219 bits (534), Expect = 1e-55
Identities = 170/581 (29%), Positives = 281/581 (48%), Gaps = 42/581 (7%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G +H A+R G+V ++ LL +G ++ T D T LH A + + E LL +GA
Sbjct: 238 NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ + K +P+H+AA+ D C +LL+ A + T D +TP+HVAA G+
Sbjct: 298 IQAK-TKNGLSPIHMAAQ-GDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAK 355
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
+LL+ G P + + G TPL +AC+ ++ L++ + A ID
Sbjct: 356 VLLDKGAKPNSR-------ALNGFTPLHIACKKNHVRVMELLLK----------TGASID 398
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
AV E G + LH A + +P +VK L++ GA ++ + ET H A AG
Sbjct: 399 AVTESGLTPLHVASFMG----HLP-----IVKNLLQRGASPNV-SNVKVETPLHMAARAG 448
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ +V ++ + + + ++A + Q TPL A GH +V LL N+A ++
Sbjct: 449 HTEVAKYLLQNKAKVN-AKAKDDQ-----TPLHCAARIGHTNMVKLLLENNANPNLATTA 502
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM 1021
G + LH+AA G+++ ALL +A + G T LH+AA G + + L+ + +A
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL-ERDAH 561
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
+ TPLH+A +++ KLLL G + + G P+H AA+ N EV +
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L Q+ A + G T H+AA +G +++ L+ G + ++ L TPL L A+
Sbjct: 622 L-QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL---TPLHLVAQ 677
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTP 1201
GH V VL++ G R G T +H+A+ +G+ ++ + + KLG +P
Sbjct: 678 EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSP 737
Query: 1202 LHIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVPVLG 1240
LH AA G + V LL + P V S+ T +++ LG
Sbjct: 738 LHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLG 778
Score = 88.6 bits (210), Expect = 2e-16
Identities = 60/205 (29%), Positives = 98/205 (47%), Gaps = 10/205 (4%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +AV N +V+ LL + A G T LH+AA++ V++AR L+ Y
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN--GYTPLHIAAKQNQVEVARSLLQY 624
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G +A + G TPLH+AA EG +V +AN + + TP+HL A+ GH +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK-------KGVYLHMPNKYFEK 233
++L K + T+ G T +H+AS G+ L + K + P +
Sbjct: 685 DVLI-KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ 743
Query: 234 QTFDEVLFVKIENGLIKGLKSDDGS 258
Q +++ + ++NG S DG+
Sbjct: 744 QGHTDIVTLLLKNGASPNEVSSDGT 768
Score = 87.4 bits (207), Expect = 5e-16
Identities = 53/159 (33%), Positives = 83/159 (52%), Gaps = 2/159 (1%)
Query: 62 RGKVPL-LLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+GKV L L + A N + Q + G T LH+AA ++++A++L++
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+ T G TPLHIA+ G+ +V+ A ++ TP+H AA NGH I
Sbjct: 229 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
E+L D A I +TK+G + +H+A+ H DC +L +
Sbjct: 289 EILLD-HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326
Score = 84.2 bits (199), Expect = 4e-15
Identities = 47/154 (30%), Positives = 79/154 (51%), Gaps = 3/154 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL +A G+ + + LL +A G T LH+A ++ V + +L+ GA +D
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNSRALN--GFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
A +G TPLH+A+ G P+VK A+ +++ + TP+H+AA GH + + L
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
KA + + KD T +H A+ GH + +L +
Sbjct: 459 N-KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Score = 82.2 bits (194), Expect = 2e-14
Identities = 56/173 (32%), Positives = 84/173 (48%), Gaps = 3/173 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D V + G PL +A G+ +V+ LL Q + +T LH+AAR ++A+
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLL--QRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+ A V+A QTPLH AA G +VK AN +A TP+H+AA GH
Sbjct: 456 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+ L +K +AS TK G T +H+A+ G A +L ++ + + K
Sbjct: 516 VETVLALLEK-EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567
Score = 79.0 bits (186), Expect = 2e-13
Identities = 60/226 (26%), Positives = 105/226 (46%), Gaps = 10/226 (4%)
Query: 4 SGRDVPRSANINFSSGVRSPPANQQKDLQRLELSFIELNKERAKQKEWKKLIRDLVFQRG 63
+G+D +N+ + V A QK L ++ E + E K +++ + G
Sbjct: 88 AGQDEVVRELVNYGANVN---AQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
PL +A++ G++++V L++ T +++ ALH+AAR D A +L+
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLP------ALHIAARNDDTRTAAVLLQNDPN 198
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
D + G TPLHIAA + + + A+ TP+H+A+ G+ ++ LL
Sbjct: 199 PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
D+ A I +TKD T +H A+ NGH + +L G + K
Sbjct: 259 LDR-GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Score = 75.4 bits (177), Expect = 2e-12
Identities = 46/120 (38%), Positives = 68/120 (56%), Gaps = 2/120 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
Q G L LA + G+ MV ELL + L+ TT G+TALH+AA ++ R LV+Y
Sbjct: 43 QNGLNGLHLASKEGHVKMVVELLHKEII--LETTTKKGNTALHIAALAGQDEVVRELVNY 100
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+A + G TPL++AA E +VK+ AN +A + TP+ +A + GH ++
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160
Score = 74.1 bits (174), Expect = 5e-12
Identities = 53/166 (31%), Positives = 84/166 (50%), Gaps = 11/166 (6%)
Query: 661 FDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
++G +H AA+ V + +LLQ G S + + T LH+A + +V LL A
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 721 DVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
+ ++ G K TPLH+ A+ +G A +L+K G + T G TP+HVA+ +GN+
Sbjct: 660 NGNL-GNKSGLTPLHLVAQ--EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIE 825
+ LL+ D KTK+ G +PL A + DIV L++
Sbjct: 717 VKFLLQHQADVNAKTKL-------GYSPLHQAAQQGHTDIVTLLLK 755
Score = 72.5 bits (170), Expect = 1e-11
Identities = 51/163 (31%), Positives = 78/163 (47%), Gaps = 3/163 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL A G+ + E+L A ++A T G + +H+AA+ +D R+L+ Y A +D
Sbjct: 275 PLHCAARNGHVR-ISEILLDHGAP-IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
TPLH+AA G + K A TP+H+A + H ++ELL
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL- 391
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
K ASI T+ G T +H+AS GH L ++G ++ N
Sbjct: 392 KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Score = 64.9 bits (151), Expect = 3e-09
Identities = 49/158 (31%), Positives = 73/158 (46%), Gaps = 3/158 (1%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL A G+ +MV+ LL L ATT AG T LH+AAR V+ L++ A
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNL-ATT-AGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
G TPLH+AA G + + A+ A TP+H+A + + I++LL
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ S +G T +HIA+ + A L + G
Sbjct: 589 LPR-GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 625
Score = 61.7 bits (143), Expect = 3e-08
Identities = 41/154 (26%), Positives = 68/154 (44%), Gaps = 3/154 (1%)
Query: 68 LLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDAT 127
L A +GN + L + + G LHLA++ V M L+ +++ T
Sbjct: 17 LRAARSGNLDKALDHL--RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
Query: 128 NGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKF 187
G T LHIAA G + +V+ AN + TP+++AA+ H +++ L +
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN- 133
Query: 188 KASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
A+ T+DG T + +A GH + L G
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 56.0 bits (129), Expect = 1e-06
Identities = 43/159 (27%), Positives = 74/159 (46%), Gaps = 3/159 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G P+ +A + + VR LL Q ++ T T LH+AA +A++L+D
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLL--QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA ++ G TPLHIA + +++ A+ TP+H+A+ GH I+
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
+ L + + K T +H+A+ GH + A L +
Sbjct: 421 KNLLQRGASPNVSNVK-VETPLHMAARAGHTEVAKYLLQ 458
Score = 52.0 bits (119), Expect = 2e-05
Identities = 32/121 (26%), Positives = 60/121 (49%), Gaps = 2/121 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL L + G+ + L+ + + ATT G T LH+A+ ++ + + L+ + A
Sbjct: 668 GLTPLHLVAQEGHVPVADVLI--KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+A G +PLH AA +G +V A+ ++ TP+ +A G+ ++ ++
Sbjct: 726 DVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDV 785
Query: 183 L 183
L
Sbjct: 786 L 786
Score = 41.5 bits (93), Expect = 0.031
Identities = 28/122 (22%), Positives = 55/122 (45%), Gaps = 1/122 (0%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T+ AAR ++D A + G ++ N G LH+A+ EG +V
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 160 ADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
+ T +H+AA G ++ L + + A++ +++ G T +++A+ H + L +
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Query: 220 KG 221
G
Sbjct: 133 NG 134
>X16609-1|CAA34610.1| 1881|Homo sapiens protein ( Human mRNA for
ankyrin (variant 2.1). ).
Length = 1881
Score = 308 bits (757), Expect = 1e-82
Identities = 232/752 (30%), Positives = 382/752 (50%), Gaps = 63/752 (8%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA+ H+ ++ LL+ G + +V T D +T L +A++ VV L+ YG
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK- 169
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
GK R LHIAAR D + A +LL++ P+ ++ G TP+H+AA + NL L
Sbjct: 170 ----GKVRLPALHIAAR-NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQL 224
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL G + G TPL +A R +VR L++ +G + T
Sbjct: 225 LLNRGAS-------VNFTPQNGITPLHIASRRGNVIMVRLLLD-----RGAQIETK---- 268
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
+D + LH C V+I + L+++GA + +T+ N + H A +
Sbjct: 269 -TKDELTPLH--CAARNGHVRIS-------EILLDHGAPIQAKTK-NGLSPIHMAAQGDH 317
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
D + ++ + + D L+ TPL +A H GH ++ LL A+ + + G
Sbjct: 318 LDCVRLLLQYDAEID-DITLDHL-----TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+ LH+A + +++V + LL A I++ +G T LH+A+ G+ +VK L++ A
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ-RGASP 430
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
+V +K +TPLH+AA +G EV K LL+ A ++A + Q P+H AA+ ++ +V+L L
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
+ + N +ATT G+T HIAA +G V+ + L++ + + + TPL +AA+
Sbjct: 491 ENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKEASQACMTKKGF---TPLHVAAKY 546
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
G V +L+ A + GLT +H+A H + +++ ++ S G TPL
Sbjct: 547 GKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606
Query: 1203 HIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRL 1262
HIAA Q E R LL + G+ +E+ GV TPLHLAA G+ +V L
Sbjct: 607 HIAAKQNQVEVARSLLQY-GGSANAESVQGV------------TPLHLAAQEGHAEMVAL 653
Query: 1263 LLNSAGVQADA-ASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIAS 1321
LL+ QA+ N++G PLHL GH+ + +L+ ++ +T R G T LH+AS
Sbjct: 654 LLSK---QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV-MVDATTRMGYTPLHVAS 709
Query: 1322 THGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCA 1381
+G+ ++V+ LL A++NA K G++PLH AA+ GH ++V LL ++GASP ++
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769
Query: 1382 PIWFAASENHNDVLEYLLHKEHDTQ-SLMDDK 1412
P+ A + V + L +T L+ DK
Sbjct: 770 PLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801
Score = 297 bits (729), Expect = 3e-79
Identities = 222/743 (29%), Positives = 374/743 (50%), Gaps = 37/743 (4%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G +H A++ GHV ++ LL K ++ TT TALHIA + + VV L+ YGA+
Sbjct: 44 NGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGAN 103
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN---LA 778
V+ + K TPL++AA+ + + LL++GA N ATEDG TP+ VA + G+ +A
Sbjct: 104 VNAQSQK-GFTPLYMAAQ-ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVA 161
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
L+ G L + + T T + PD++ F H
Sbjct: 162 HLINYGTKGKVRLPALHIAARNDDT-RTAAVLLQNDPNPDVLSK-TGFTPLHIAAHYENL 219
Query: 839 FIDAVDEDGASALHYACK--VTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHY 896
+ + + +++++ + +T + + +V+ L++ GA + +T+ + T H
Sbjct: 220 NVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPLH- 277
Query: 897 CAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVD 956
CA + ++E++ D + + G +P+ +A H+ V LL A +D
Sbjct: 278 CAARNGHVRISEIL-----LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Query: 957 VFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIR 1016
++ + LH+AA G+ +V LL A NS+A NG T LH+A + +++ L++
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Query: 1017 DHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSE 1076
A ID +T TPLH+A+ G + + K LL+ GA+ + ++ + P+H AA+ ++E
Sbjct: 393 T-GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTE 451
Query: 1077 VVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPL 1136
V + +L Q+ V A KD T H AA G +++ L++ + ++ TPL
Sbjct: 452 VAK-YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT---TAGHTPL 507
Query: 1137 QLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
+AA GH + V L+ AS + G T +H+AA++G V +++ + ++ K
Sbjct: 508 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567
Query: 1197 LGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGN 1256
GLTPLH+A ++ + V+ LL P G S P A +G TPLH+AA
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLL-----------PRGGS--PHSPAWNGYTPLHIAAKQNQ 614
Query: 1257 ENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTG 1316
V R LL G A+A S + G PLHLA GH +V LLLS+ A + ++ G T
Sbjct: 615 VEVARSLLQYGG-SANAESVQ-GVTPLHLAAQEGHAEMVALLLSKQAN-GNLGNKSGLTP 671
Query: 1317 LHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSET 1376
LH+ + GH + +VL+ G ++AT + G+TPLH A+ G++ +VK L + A ++T
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731
Query: 1377 NLNCAPIWFAASENHNDVLEYLL 1399
L +P+ AA + H D++ LL
Sbjct: 732 KLGYSPLHQAAQQGHTDIVTLLL 754
Score = 276 bits (677), Expect = 5e-73
Identities = 231/790 (29%), Positives = 368/790 (46%), Gaps = 63/790 (7%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
++ D A S AAR G++ L+ G ++ + LH+A + +V LL
Sbjct: 7 FREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL- 65
Query: 718 YGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
+ + K+ T LHIAA + D+ L+ GA N ++ G TP+++AA+ +L
Sbjct: 66 HKEIILETTTKKGNTALHIAA-LAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 778 ATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVST 837
+ LLE+G + T+ G TPL +A + ++V HLI + KG+
Sbjct: 125 EVVKFLLENGANQNVATE-------DGFTPLAVALQQGHENVVAHLINY--GTKGKV--- 172
Query: 838 AFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYC 897
ALH A + D + L++N + + ++ T H
Sbjct: 173 ---------RLPALHIAAR---------NDDTRTAAVLLQNDPNPDVLSKTGF-TPLHIA 213
Query: 898 AIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
A N +V ++ S QN I TPL IA RG++ +V LL A+++
Sbjct: 214 AHYENLNVAQLLL----NRGASVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 958 FDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRD 1017
+ + LH AA +G++++ + LL + A I +K +NG + +H+AA + V+ L++
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ- 326
Query: 1018 HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEV 1077
++A ID +TL TPLH+AA G V K+LL+ GA ++ G P+H A + N+ V
Sbjct: 327 YDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
Query: 1078 VQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
++L L+ + + A T+ G T H+A+ G + +++ L+ + G + + TPL
Sbjct: 387 MELLLKTGAS-IDAVTESGLTPLHVASFMGHLPIVKNLL---QRGASPNVSNVKVETPLH 442
Query: 1138 LAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKL 1197
+AA GH +V + L++ A + + T +H AA GHTN++ ++ N +
Sbjct: 443 MAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA 502
Query: 1198 GLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNE 1257
G TPLHIAA G ETV LL + EA + G TPLH+AA G
Sbjct: 503 GHTPLHIAAREGHVETVLALL-------EKEASQACM------TKKGFTPLHVAAKYGKV 549
Query: 1258 NVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGL 1317
V LLL A+ +NG PLH+A ++ IV LLL R HS +G T L
Sbjct: 550 RVAELLLERDA--HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS-PHSPAWNGYTPL 606
Query: 1318 HIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETN 1377
HIA+ ++ LL G NA G TPLH AA+ GH +V LL A+
Sbjct: 607 HIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK 666
Query: 1378 LNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVS 1437
P+ A E H V + L+ +H + R Y + + ++ NI + +F+L
Sbjct: 667 SGLTPLHLVAQEGHVPVADVLI--KHGVM-VDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 1438 PAPVDTAAKL 1447
A V+ KL
Sbjct: 724 QADVNAKTKL 733
Score = 225 bits (551), Expect = 1e-57
Identities = 185/597 (30%), Positives = 291/597 (48%), Gaps = 39/597 (6%)
Query: 876 IENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLI 935
+ NG D++ N H + G+ ++ E++ H L G T L I
Sbjct: 32 LRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELL-HKEII-----LETTTKKGNTALHI 84
Query: 936 ACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNG 995
A G ++V L+ A V+ +G + L++AA+ +L+V LL N A N +G
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 996 RTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANI 1055
T L +A G+ ++V LI ++ V + LH+AA + +LL+ N
Sbjct: 145 FTPLAVALQQGHENVVAHLI-NYGTKGKV----RLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 1056 DATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEEL 1115
D + G P+H AA V QL L + + V T ++G T HIA+ +G+V ++ L
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS-VNFTPQNGITPLHIASRRGNVIMVRLL 258
Query: 1116 MKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEH 1175
+ DR I + K ++ TPL AA GH + +L+ GA + + GL+ +H+AA+
Sbjct: 259 L--DRGAQIETKTK-DELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 1176 GHTNVLDVMRSTNTLRISSKKLG-LTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVS 1234
H + + ++ + I L LTPLH+AA+ G + LL K P +
Sbjct: 316 DHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHHRVAKVLLD------KGAKPNSRA 368
Query: 1235 LVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSI 1294
L +G TPLH+A + V+ LLL + G DA + E+G PLH+A F GH+ I
Sbjct: 369 L-------NGFTPLHIACKKNHVRVMELLLKT-GASIDAVT-ESGLTPLHVASFMGHLPI 419
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
V LL R A S + +T LH+A+ GH ++ + LL A++NA K+ TPLHCAA
Sbjct: 420 VKNLLQRGASPNVSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRF 1414
+ GH N+VKLL E+ A+P T P+ AA E H + + LL KE +Q+ M K F
Sbjct: 479 RIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE-ASQACMTKKGF 537
Query: 1415 VYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAK--LSNIYINLSTKEKERAKDLIAAG 1469
L V +K + + + E +L A + A K L+ +++ + + K L+ G
Sbjct: 538 T-PLHVAAK-YGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Score = 219 bits (534), Expect = 1e-55
Identities = 170/581 (29%), Positives = 281/581 (48%), Gaps = 42/581 (7%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G +H A+R G+V ++ LL +G ++ T D T LH A + + E LL +GA
Sbjct: 238 NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ + K +P+H+AA+ D C +LL+ A + T D +TP+HVAA G+
Sbjct: 298 IQAK-TKNGLSPIHMAAQ-GDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAK 355
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
+LL+ G P + + G TPL +AC+ ++ L++ + A ID
Sbjct: 356 VLLDKGAKPNSR-------ALNGFTPLHIACKKNHVRVMELLLK----------TGASID 398
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
AV E G + LH A + +P +VK L++ GA ++ + ET H A AG
Sbjct: 399 AVTESGLTPLHVASFMG----HLP-----IVKNLLQRGASPNV-SNVKVETPLHMAARAG 448
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ +V ++ + + + ++A + Q TPL A GH +V LL N+A ++
Sbjct: 449 HTEVAKYLLQNKAKVN-AKAKDDQ-----TPLHCAARIGHTNMVKLLLENNANPNLATTA 502
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM 1021
G + LH+AA G+++ ALL +A + G T LH+AA G + + L+ + +A
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL-ERDAH 561
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
+ TPLH+A +++ KLLL G + + G P+H AA+ N EV +
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L Q+ A + G T H+AA +G +++ L+ G + ++ L TPL L A+
Sbjct: 622 L-QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL---TPLHLVAQ 677
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTP 1201
GH V VL++ G R G T +H+A+ +G+ ++ + + KLG +P
Sbjct: 678 EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSP 737
Query: 1202 LHIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVPVLG 1240
LH AA G + V LL + P V S+ T +++ LG
Sbjct: 738 LHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLG 778
Score = 88.6 bits (210), Expect = 2e-16
Identities = 60/205 (29%), Positives = 98/205 (47%), Gaps = 10/205 (4%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +AV N +V+ LL + A G T LH+AA++ V++AR L+ Y
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN--GYTPLHIAAKQNQVEVARSLLQY 624
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G +A + G TPLH+AA EG +V +AN + + TP+HL A+ GH +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK-------KGVYLHMPNKYFEK 233
++L K + T+ G T +H+AS G+ L + K + P +
Sbjct: 685 DVLI-KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ 743
Query: 234 QTFDEVLFVKIENGLIKGLKSDDGS 258
Q +++ + ++NG S DG+
Sbjct: 744 QGHTDIVTLLLKNGASPNEVSSDGT 768
Score = 87.4 bits (207), Expect = 5e-16
Identities = 53/159 (33%), Positives = 83/159 (52%), Gaps = 2/159 (1%)
Query: 62 RGKVPL-LLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+GKV L L + A N + Q + G T LH+AA ++++A++L++
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+ T G TPLHIA+ G+ +V+ A ++ TP+H AA NGH I
Sbjct: 229 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
E+L D A I +TK+G + +H+A+ H DC +L +
Sbjct: 289 EILLD-HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326
Score = 84.2 bits (199), Expect = 4e-15
Identities = 47/154 (30%), Positives = 79/154 (51%), Gaps = 3/154 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL +A G+ + + LL +A G T LH+A ++ V + +L+ GA +D
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNSRALN--GFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
A +G TPLH+A+ G P+VK A+ +++ + TP+H+AA GH + + L
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
KA + + KD T +H A+ GH + +L +
Sbjct: 459 N-KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Score = 82.2 bits (194), Expect = 2e-14
Identities = 56/173 (32%), Positives = 84/173 (48%), Gaps = 3/173 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D V + G PL +A G+ +V+ LL Q + +T LH+AAR ++A+
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLL--QRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+ A V+A QTPLH AA G +VK AN +A TP+H+AA GH
Sbjct: 456 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+ L +K +AS TK G T +H+A+ G A +L ++ + + K
Sbjct: 516 VETVLALLEK-EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567
Score = 79.0 bits (186), Expect = 2e-13
Identities = 60/226 (26%), Positives = 105/226 (46%), Gaps = 10/226 (4%)
Query: 4 SGRDVPRSANINFSSGVRSPPANQQKDLQRLELSFIELNKERAKQKEWKKLIRDLVFQRG 63
+G+D +N+ + V A QK L ++ E + E K +++ + G
Sbjct: 88 AGQDEVVRELVNYGANVN---AQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
PL +A++ G++++V L++ T +++ ALH+AAR D A +L+
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLP------ALHIAARNDDTRTAAVLLQNDPN 198
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
D + G TPLHIAA + + + A+ TP+H+A+ G+ ++ LL
Sbjct: 199 PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
D+ A I +TKD T +H A+ NGH + +L G + K
Sbjct: 259 LDR-GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Score = 75.4 bits (177), Expect = 2e-12
Identities = 46/120 (38%), Positives = 68/120 (56%), Gaps = 2/120 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
Q G L LA + G+ MV ELL + L+ TT G+TALH+AA ++ R LV+Y
Sbjct: 43 QNGLNGLHLASKEGHVKMVVELLHKEII--LETTTKKGNTALHIAALAGQDEVVRELVNY 100
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+A + G TPL++AA E +VK+ AN +A + TP+ +A + GH ++
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160
Score = 74.1 bits (174), Expect = 5e-12
Identities = 53/166 (31%), Positives = 84/166 (50%), Gaps = 11/166 (6%)
Query: 661 FDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
++G +H AA+ V + +LLQ G S + + T LH+A + +V LL A
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 721 DVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
+ ++ G K TPLH+ A+ +G A +L+K G + T G TP+HVA+ +GN+
Sbjct: 660 NGNL-GNKSGLTPLHLVAQ--EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIE 825
+ LL+ D KTK+ G +PL A + DIV L++
Sbjct: 717 VKFLLQHQADVNAKTKL-------GYSPLHQAAQQGHTDIVTLLLK 755
Score = 72.5 bits (170), Expect = 1e-11
Identities = 51/163 (31%), Positives = 78/163 (47%), Gaps = 3/163 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL A G+ + E+L A ++A T G + +H+AA+ +D R+L+ Y A +D
Sbjct: 275 PLHCAARNGHVR-ISEILLDHGAP-IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
TPLH+AA G + K A TP+H+A + H ++ELL
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL- 391
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
K ASI T+ G T +H+AS GH L ++G ++ N
Sbjct: 392 KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Score = 64.9 bits (151), Expect = 3e-09
Identities = 49/158 (31%), Positives = 73/158 (46%), Gaps = 3/158 (1%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL A G+ +MV+ LL L ATT AG T LH+AAR V+ L++ A
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNL-ATT-AGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
G TPLH+AA G + + A+ A TP+H+A + + I++LL
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ S +G T +HIA+ + A L + G
Sbjct: 589 LPR-GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 625
Score = 61.7 bits (143), Expect = 3e-08
Identities = 41/154 (26%), Positives = 68/154 (44%), Gaps = 3/154 (1%)
Query: 68 LLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDAT 127
L A +GN + L + + G LHLA++ V M L+ +++ T
Sbjct: 17 LRAARSGNLDKALDHL--RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
Query: 128 NGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKF 187
G T LHIAA G + +V+ AN + TP+++AA+ H +++ L +
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN- 133
Query: 188 KASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
A+ T+DG T + +A GH + L G
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 56.0 bits (129), Expect = 1e-06
Identities = 43/159 (27%), Positives = 74/159 (46%), Gaps = 3/159 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G P+ +A + + VR LL Q ++ T T LH+AA +A++L+D
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLL--QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA ++ G TPLHIA + +++ A+ TP+H+A+ GH I+
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
+ L + + K T +H+A+ GH + A L +
Sbjct: 421 KNLLQRGASPNVSNVK-VETPLHMAARAGHTEVAKYLLQ 458
Score = 52.0 bits (119), Expect = 2e-05
Identities = 32/121 (26%), Positives = 60/121 (49%), Gaps = 2/121 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL L + G+ + L+ + + ATT G T LH+A+ ++ + + L+ + A
Sbjct: 668 GLTPLHLVAQEGHVPVADVLI--KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+A G +PLH AA +G +V A+ ++ TP+ +A G+ ++ ++
Sbjct: 726 DVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDV 785
Query: 183 L 183
L
Sbjct: 786 L 786
Score = 41.5 bits (93), Expect = 0.031
Identities = 28/122 (22%), Positives = 55/122 (45%), Gaps = 1/122 (0%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T+ AAR ++D A + G ++ N G LH+A+ EG +V
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 160 ADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
+ T +H+AA G ++ L + + A++ +++ G T +++A+ H + L +
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Query: 220 KG 221
G
Sbjct: 133 NG 134
>U50133-1|AAB47805.1| 1856|Homo sapiens ankyrin protein.
Length = 1856
Score = 308 bits (757), Expect = 1e-82
Identities = 232/752 (30%), Positives = 382/752 (50%), Gaps = 63/752 (8%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA+ H+ ++ LL+ G + +V T D +T L +A++ VV L+ YG
Sbjct: 78 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK- 136
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
GK R LHIAAR D + A +LL++ P+ ++ G TP+H+AA + NL L
Sbjct: 137 ----GKVRLPALHIAAR-NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQL 191
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL G + G TPL +A R +VR L++ +G + T
Sbjct: 192 LLNRGAS-------VNFTPQNGITPLHIASRRGNVIMVRLLLD-----RGAQIETK---- 235
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
+D + LH C V+I + L+++GA + +T+ N + H A +
Sbjct: 236 -TKDELTPLH--CAARNGHVRIS-------EILLDHGAPIQAKTK-NGLSPIHMAAQGDH 284
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
D + ++ + + D L+ TPL +A H GH ++ LL A+ + + G
Sbjct: 285 LDCVRLLLQYDAEID-DITLDHL-----TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 338
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+ LH+A + +++V + LL A I++ +G T LH+A+ G+ +VK L++ A
Sbjct: 339 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ-RGASP 397
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
+V +K +TPLH+AA +G EV K LL+ A ++A + Q P+H AA+ ++ +V+L L
Sbjct: 398 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 457
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
+ + N +ATT G+T HIAA +G V+ + L++ + + + TPL +AA+
Sbjct: 458 ENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKEASQACMTKKGF---TPLHVAAKY 513
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
G V +L+ A + GLT +H+A H + +++ ++ S G TPL
Sbjct: 514 GKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 573
Query: 1203 HIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRL 1262
HIAA Q E R LL + G+ +E+ GV TPLHLAA G+ +V L
Sbjct: 574 HIAAKQNQVEVARSLLQY-GGSANAESVQGV------------TPLHLAAQEGHAEMVAL 620
Query: 1263 LLNSAGVQADA-ASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIAS 1321
LL+ QA+ N++G PLHL GH+ + +L+ ++ +T R G T LH+AS
Sbjct: 621 LLSK---QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV-MVDATTRMGYTPLHVAS 676
Query: 1322 THGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCA 1381
+G+ ++V+ LL A++NA K G++PLH AA+ GH ++V LL ++GASP ++
Sbjct: 677 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 736
Query: 1382 PIWFAASENHNDVLEYLLHKEHDTQ-SLMDDK 1412
P+ A + V + L +T L+ DK
Sbjct: 737 PLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 768
Score = 287 bits (705), Expect = 2e-76
Identities = 220/747 (29%), Positives = 371/747 (49%), Gaps = 37/747 (4%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
++ D A S AAR G++ L+ G ++ TALHIA + + VV L+
Sbjct: 7 FREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQKGNTALHIAALAGQDEVVRELVN 66
Query: 718 YGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN- 776
YGA+V+ + K TPL++AA+ + + LL++GA N ATEDG TP+ VA + G+
Sbjct: 67 YGANVNAQSQK-GFTPLYMAAQ-ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE 124
Query: 777 --LATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGES 834
+A L+ G L + + T T + PD++ F H
Sbjct: 125 NVVAHLINYGTKGKVRLPALHIAARNDDT-RTAAVLLQNDPNPDVLSK-TGFTPLHIAAH 182
Query: 835 VSTAFIDAVDEDGASALHYACK--VTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHET 892
+ + + +++++ + +T + + +V+ L++ GA + +T+ + T
Sbjct: 183 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELT 241
Query: 893 AFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
H CA + ++E++ D + + G +P+ +A H+ V LL
Sbjct: 242 PLH-CAARNGHVRISEIL-----LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 295
Query: 953 ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVK 1012
A +D ++ + LH+AA G+ +V LL A NS+A NG T LH+A + +++
Sbjct: 296 AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVME 355
Query: 1013 FLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN 1072
L++ A ID +T TPLH+A+ G + + K LL+ GA+ + ++ + P+H AA+
Sbjct: 356 LLLKT-GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 414
Query: 1073 NYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLND 1132
++EV + +L Q+ V A KD T H AA G +++ L++ + ++
Sbjct: 415 GHTEVAK-YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT---TAG 470
Query: 1133 STPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
TPL +AA GH + V L+ AS + G T +H+AA++G V +++ +
Sbjct: 471 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 530
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K GLTPLH+A ++ + V+ LL P G S P A +G TPLH+AA
Sbjct: 531 AAGKNGLTPLHVAVHHNNLDIVKLLL-----------PRGGS--PHSPAWNGYTPLHIAA 577
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
V R LL G A+A S + G PLHLA GH +V LLLS+ A + ++
Sbjct: 578 KQNQVEVARSLLQYGG-SANAESVQ-GVTPLHLAAQEGHAEMVALLLSKQAN-GNLGNKS 634
Query: 1313 GKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASP 1372
G T LH+ + GH + +VL+ G ++AT + G+TPLH A+ G++ +VK L + A
Sbjct: 635 GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 694
Query: 1373 KSETNLNCAPIWFAASENHNDVLEYLL 1399
++T L +P+ AA + H D++ LL
Sbjct: 695 NAKTKLGYSPLHQAAQQGHTDIVTLLL 721
Score = 234 bits (573), Expect = 2e-60
Identities = 180/560 (32%), Positives = 271/560 (48%), Gaps = 35/560 (6%)
Query: 876 IENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLI 935
+ NG D++ + + TA H A+AG ++V+ E++ + +N Q+ G+TPL +
Sbjct: 32 LRNGVDINTCNQKGN-TALHIAALAGQDEVVRELV------NYGANVNAQSQKGFTPLYM 84
Query: 936 ACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNG 995
A H+++V LL N A +V +G + L +A + G+ V L+ +K +
Sbjct: 85 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN----YGTKGKVR 140
Query: 996 RTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANI 1055
ALH+AA N L++ ++ DVL+ TPLH+AA + V +LLL GA++
Sbjct: 141 LPALHIAARNDDTRTAAVLLQ-NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 199
Query: 1056 DATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEEL 1115
+ T + G P+H A++ +V+L L + + TKD T H AA G V++ E L
Sbjct: 200 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ-IETKTKDELTPLHCAARNGHVRISEIL 258
Query: 1116 MKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEH 1175
+ D I A+ K N +P+ +AA+G H D VR+L++ A D LT +H+AA
Sbjct: 259 L--DHGAPIQAKTK-NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 315
Query: 1176 GHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSL 1235
GH V V+ S G TPLHIA + LL TG S+
Sbjct: 316 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK-----------TGASI 364
Query: 1236 VPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIV 1295
V ESGLTPLH+A++ G+ +V+ LL + SN PLH+A GH +
Sbjct: 365 DAV--TESGLTPLHVASFMGHLPIVKNLLQRGA--SPNVSNVKVETPLHMAARAGHTEVA 420
Query: 1296 GLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAK 1355
LL A+ +++ + +T LH A+ GH MV++LL A N G TPLH AA+
Sbjct: 421 KYLLQNKAK-VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAR 479
Query: 1356 AGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFV 1415
GH+ V L E AS T P+ AA V E LL E D K +
Sbjct: 480 EGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL--ERDAHPNAAGKNGL 537
Query: 1416 YNLMVCSKNHNNIPIEEFVL 1435
L V + +HNN+ I + +L
Sbjct: 538 TPLHV-AVHHNNLDIVKLLL 556
Score = 227 bits (556), Expect = 2e-58
Identities = 178/551 (32%), Positives = 276/551 (50%), Gaps = 32/551 (5%)
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
+N N G T L IA G ++V L+ A V+ +G + L++AA+ +L+V L
Sbjct: 38 INTCNQKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 97
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
L N A N +G T L +A G+ ++V LI ++ V + LH+AA +
Sbjct: 98 LENGANQNVATEDGFTPLAVALQQGHENVVAHLI-NYGTKGKV----RLPALHIAARNDD 152
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAH 1101
+LL+ N D + G P+H AA V QL L + + V T ++G T H
Sbjct: 153 TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS-VNFTPQNGITPLH 211
Query: 1102 IAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDE 1161
IA+ +G+V ++ L+ DR I + K ++ TPL AA GH + +L+ GA +
Sbjct: 212 IASRRGNVIMVRLLL--DRGAQIETKTK-DELTPLHCAARNGHVRISEILLDHGAPIQAK 268
Query: 1162 NRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLG-LTPLHIAAYYGQAETVRELLSH 1220
+ GL+ +H+AA+ H + + ++ + I L LTPLH+AA+ G + LL
Sbjct: 269 TKNGLSPIHMAAQGDHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHHRVAKVLLD- 326
Query: 1221 VPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGY 1280
K P +L +G TPLH+A + V+ LLL + G DA + E+G
Sbjct: 327 -----KGAKPNSRAL-------NGFTPLHIACKKNHVRVMELLLKT-GASIDAVT-ESGL 372
Query: 1281 NPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN 1340
PLH+A F GH+ IV LL R A S + +T LH+A+ GH ++ + LL A++N
Sbjct: 373 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVN 431
Query: 1341 ATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
A K+ TPLHCAA+ GH N+VKLL E+ A+P T P+ AA E H + + LL
Sbjct: 432 AKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE 491
Query: 1401 KEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAK--LSNIYINLSTKE 1458
KE +Q+ M K F L V +K + + + E +L A + A K L+ +++ +
Sbjct: 492 KE-ASQACMTKKGFT-PLHVAAK-YGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 548
Query: 1459 KERAKDLIAAG 1469
+ K L+ G
Sbjct: 549 LDIVKLLLPRG 559
Score = 219 bits (534), Expect = 1e-55
Identities = 170/581 (29%), Positives = 281/581 (48%), Gaps = 42/581 (7%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G +H A+R G+V ++ LL +G ++ T D T LH A + + E LL +GA
Sbjct: 205 NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 264
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ + K +P+H+AA+ D C +LL+ A + T D +TP+HVAA G+
Sbjct: 265 IQAK-TKNGLSPIHMAAQ-GDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAK 322
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
+LL+ G P + + G TPL +AC+ ++ L++ + A ID
Sbjct: 323 VLLDKGAKPNSR-------ALNGFTPLHIACKKNHVRVMELLLK----------TGASID 365
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
AV E G + LH A + +P +VK L++ GA ++ + ET H A AG
Sbjct: 366 AVTESGLTPLHVASFMG----HLP-----IVKNLLQRGASPNV-SNVKVETPLHMAARAG 415
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ +V ++ + + + ++A + Q TPL A GH +V LL N+A ++
Sbjct: 416 HTEVAKYLLQNKAKVN-AKAKDDQ-----TPLHCAARIGHTNMVKLLLENNANPNLATTA 469
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM 1021
G + LH+AA G+++ ALL +A + G T LH+AA G + + L+ + +A
Sbjct: 470 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL-ERDAH 528
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
+ TPLH+A +++ KLLL G + + G P+H AA+ N EV +
Sbjct: 529 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 588
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L Q+ A + G T H+AA +G +++ L+ G + ++ L TPL L A+
Sbjct: 589 L-QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL---TPLHLVAQ 644
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTP 1201
GH V VL++ G R G T +H+A+ +G+ ++ + + KLG +P
Sbjct: 645 EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSP 704
Query: 1202 LHIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVPVLG 1240
LH AA G + V LL + P V S+ T +++ LG
Sbjct: 705 LHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLG 745
Score = 120 bits (288), Expect = 7e-26
Identities = 95/296 (32%), Positives = 150/296 (50%), Gaps = 21/296 (7%)
Query: 1133 STPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVL-DVMRSTNTLR 1191
+T AA G+ D +R G N+ G TA+H+AA G V+ +++ +
Sbjct: 13 ATSFLRAARSGNLDKALDHLRNGVDINTCNQKGNTALHIAALAGQDEVVRELVNYGANVN 72
Query: 1192 ISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTVKSE---APTGVSL-------VPVL- 1239
S+K G TPL++AA E V+ LL + V +E P V+L V L
Sbjct: 73 AQSQK-GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI 131
Query: 1240 --GAES--GLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIV 1295
G + L LH+AA N + +LL + D S + G+ PLH+A ++++
Sbjct: 132 NYGTKGKVRLPALHIAARNDDTRTAAVLLQN-DPNPDVLS-KTGFTPLHIAAHYENLNVA 189
Query: 1296 GLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAK 1355
LLL+R A ++ T ++G T LHIAS G+ MV +LL +GA+I K+ TPLHCAA+
Sbjct: 190 QLLLNRGAS-VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAAR 248
Query: 1356 AGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDD 1411
GH+ + ++L + GA +++T +PI AA +H D + LL + + + D
Sbjct: 249 NGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD 304
Score = 88.6 bits (210), Expect = 2e-16
Identities = 60/205 (29%), Positives = 98/205 (47%), Gaps = 10/205 (4%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +AV N +V+ LL + A G T LH+AA++ V++AR L+ Y
Sbjct: 534 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN--GYTPLHIAAKQNQVEVARSLLQY 591
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G +A + G TPLH+AA EG +V +AN + + TP+HL A+ GH +
Sbjct: 592 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 651
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK-------KGVYLHMPNKYFEK 233
++L K + T+ G T +H+AS G+ L + K + P +
Sbjct: 652 DVLI-KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ 710
Query: 234 QTFDEVLFVKIENGLIKGLKSDDGS 258
Q +++ + ++NG S DG+
Sbjct: 711 QGHTDIVTLLLKNGASPNEVSSDGT 735
Score = 87.4 bits (207), Expect = 5e-16
Identities = 53/159 (33%), Positives = 83/159 (52%), Gaps = 2/159 (1%)
Query: 62 RGKVPL-LLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+GKV L L + A N + Q + G T LH+AA ++++A++L++
Sbjct: 136 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 195
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+ T G TPLHIA+ G+ +V+ A ++ TP+H AA NGH I
Sbjct: 196 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 255
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
E+L D A I +TK+G + +H+A+ H DC +L +
Sbjct: 256 EILLD-HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 293
Score = 84.2 bits (199), Expect = 4e-15
Identities = 47/154 (30%), Positives = 79/154 (51%), Gaps = 3/154 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL +A G+ + + LL +A G T LH+A ++ V + +L+ GA +D
Sbjct: 308 PLHVAAHCGHHRVAKVLLDKGAKPNSRALN--GFTPLHIACKKNHVRVMELLLKTGASID 365
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
A +G TPLH+A+ G P+VK A+ +++ + TP+H+AA GH + + L
Sbjct: 366 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 425
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
KA + + KD T +H A+ GH + +L +
Sbjct: 426 N-KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 458
Score = 82.2 bits (194), Expect = 2e-14
Identities = 56/173 (32%), Positives = 84/173 (48%), Gaps = 3/173 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D V + G PL +A G+ +V+ LL Q + +T LH+AAR ++A+
Sbjct: 365 DAVTESGLTPLHVASFMGHLPIVKNLL--QRGASPNVSNVKVETPLHMAARAGHTEVAKY 422
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+ A V+A QTPLH AA G +VK AN +A TP+H+AA GH
Sbjct: 423 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 482
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+ L +K +AS TK G T +H+A+ G A +L ++ + + K
Sbjct: 483 VETVLALLEK-EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 534
Score = 79.0 bits (186), Expect = 2e-13
Identities = 60/226 (26%), Positives = 105/226 (46%), Gaps = 10/226 (4%)
Query: 4 SGRDVPRSANINFSSGVRSPPANQQKDLQRLELSFIELNKERAKQKEWKKLIRDLVFQRG 63
+G+D +N+ + V A QK L ++ E + E K +++ + G
Sbjct: 55 AGQDEVVRELVNYGANVN---AQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 111
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
PL +A++ G++++V L++ T +++ ALH+AAR D A +L+
Sbjct: 112 FTPLAVALQQGHENVVAHLINYGTKGKVRLP------ALHIAARNDDTRTAAVLLQNDPN 165
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
D + G TPLHIAA + + + A+ TP+H+A+ G+ ++ LL
Sbjct: 166 PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 225
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
D+ A I +TKD T +H A+ NGH + +L G + K
Sbjct: 226 LDR-GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 270
Score = 74.1 bits (174), Expect = 5e-12
Identities = 53/166 (31%), Positives = 84/166 (50%), Gaps = 11/166 (6%)
Query: 661 FDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
++G +H AA+ V + +LLQ G S + + T LH+A + +V LL A
Sbjct: 567 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 626
Query: 721 DVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
+ ++ G K TPLH+ A+ +G A +L+K G + T G TP+HVA+ +GN+
Sbjct: 627 NGNL-GNKSGLTPLHLVAQ--EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 683
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIE 825
+ LL+ D KTK+ G +PL A + DIV L++
Sbjct: 684 VKFLLQHQADVNAKTKL-------GYSPLHQAAQQGHTDIVTLLLK 722
Score = 72.5 bits (170), Expect = 1e-11
Identities = 51/163 (31%), Positives = 78/163 (47%), Gaps = 3/163 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL A G+ + E+L A ++A T G + +H+AA+ +D R+L+ Y A +D
Sbjct: 242 PLHCAARNGHVR-ISEILLDHGAP-IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 299
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
TPLH+AA G + K A TP+H+A + H ++ELL
Sbjct: 300 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL- 358
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
K ASI T+ G T +H+AS GH L ++G ++ N
Sbjct: 359 KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 401
Score = 64.9 bits (151), Expect = 3e-09
Identities = 49/158 (31%), Positives = 73/158 (46%), Gaps = 3/158 (1%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL A G+ +MV+ LL L ATT AG T LH+AAR V+ L++ A
Sbjct: 438 QTPLHCAARIGHTNMVKLLLENNANPNL-ATT-AGHTPLHIAAREGHVETVLALLEKEAS 495
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
G TPLH+AA G + + A+ A TP+H+A + + I++LL
Sbjct: 496 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 555
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ S +G T +HIA+ + A L + G
Sbjct: 556 LPR-GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 592
Score = 62.9 bits (146), Expect = 1e-08
Identities = 37/113 (32%), Positives = 59/113 (52%), Gaps = 2/113 (1%)
Query: 68 LLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDAT 127
L A +GN + L + + G+TALH+AA ++ R LV+YGA V+A
Sbjct: 17 LRAARSGNLDKALDHL--RNGVDINTCNQKGNTALHIAALAGQDEVVRELVNYGANVNAQ 74
Query: 128 NGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
+ G TPL++AA E +VK+ AN +A + TP+ +A + GH ++
Sbjct: 75 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 127
Score = 57.2 bits (132), Expect = 6e-07
Identities = 44/164 (26%), Positives = 78/164 (47%), Gaps = 13/164 (7%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
Q+G L +A AG +VREL++ + A + G T L++AA+ +++ + L++
Sbjct: 43 QKGNTALHIAALAGQDEVVRELVN--YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 100
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYF--YGVRANAAIADNEDRTPMHLAAENGHA- 177
GA + G TPL +A +G E +V + YG + + +H+AA N
Sbjct: 101 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL------PALHIAARNDDTR 154
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LL + + +T G T +HIA+ + + A +L +G
Sbjct: 155 TAAVLLQNDPNPDVLSKT--GFTPLHIAAHYENLNVAQLLLNRG 196
Score = 56.8 bits (131), Expect = 8e-07
Identities = 35/122 (28%), Positives = 58/122 (47%), Gaps = 1/122 (0%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T+ AAR ++D A + G ++ N G T LHIAA G + +V+ AN
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQKGNTALHIAALAGQDEVVRELVNYGANVNA 73
Query: 160 ADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
+ TP+++AA+ H +++ L + A+ T+DG T + +A GH + L
Sbjct: 74 QSQKGFTPLYMAAQENHLEVVKFLLEN-GANQNVATEDGFTPLAVALQQGHENVVAHLIN 132
Query: 220 KG 221
G
Sbjct: 133 YG 134
Score = 56.0 bits (129), Expect = 1e-06
Identities = 43/159 (27%), Positives = 74/159 (46%), Gaps = 3/159 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G P+ +A + + VR LL Q ++ T T LH+AA +A++L+D
Sbjct: 270 KNGLSPIHMAAQGDHLDCVRLLL--QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 327
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA ++ G TPLHIA + +++ A+ TP+H+A+ GH I+
Sbjct: 328 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 387
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
+ L + + K T +H+A+ GH + A L +
Sbjct: 388 KNLLQRGASPNVSNVK-VETPLHMAARAGHTEVAKYLLQ 425
Score = 52.0 bits (119), Expect = 2e-05
Identities = 32/121 (26%), Positives = 60/121 (49%), Gaps = 2/121 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL L + G+ + L+ + + ATT G T LH+A+ ++ + + L+ + A
Sbjct: 635 GLTPLHLVAQEGHVPVADVLI--KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 692
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+A G +PLH AA +G +V A+ ++ TP+ +A G+ ++ ++
Sbjct: 693 DVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDV 752
Query: 183 L 183
L
Sbjct: 753 L 753
>M28880-1|AAA51732.1| 1880|Homo sapiens ankyrin protein.
Length = 1880
Score = 308 bits (757), Expect = 1e-82
Identities = 232/752 (30%), Positives = 382/752 (50%), Gaps = 63/752 (8%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA+ H+ ++ LL+ G + +V T D +T L +A++ VV L+ YG
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK- 169
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
GK R LHIAAR D + A +LL++ P+ ++ G TP+H+AA + NL L
Sbjct: 170 ----GKVRLPALHIAAR-NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQL 224
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL G + G TPL +A R +VR L++ +G + T
Sbjct: 225 LLNRGSS-------VNFTPQNGITPLHIASRRGNVIMVRLLLD-----RGAQIETK---- 268
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
+D + LH C V+I + L+++GA + +T+ N + H A +
Sbjct: 269 -TKDELTPLH--CAARNGHVRIS-------EILLDHGAPIQAKTK-NGLSPIHMAAQGDH 317
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
D + ++ + + D L+ TPL +A H GH ++ LL A+ + + G
Sbjct: 318 LDCVRLLLQYDAEID-DITLDHL-----TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+ LH+A + +++V + LL A I++ +G T LH+A+ G+ +VK L++ A
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ-RGASP 430
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
+V +K +TPLH+AA +G EV K LL+ A ++A + Q P+H AA+ ++ +V+L L
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
+ + N +ATT G+T HIAA +G V+ + L++ + + + TPL +AA+
Sbjct: 491 ENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKEASQACMTKKGF---TPLHVAAKY 546
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
G V +L+ A + GLT +H+A H + +++ ++ S G TPL
Sbjct: 547 GKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 606
Query: 1203 HIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRL 1262
HIAA Q E R LL + G+ +E+ GV TPLHLAA G+ +V L
Sbjct: 607 HIAAKQNQVEVARSLLQY-GGSANAESVQGV------------TPLHLAAQEGHAEMVAL 653
Query: 1263 LLNSAGVQADA-ASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIAS 1321
LL+ QA+ N++G PLHL GH+ + +L+ ++ +T R G T LH+AS
Sbjct: 654 LLSK---QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV-MVDATTRMGYTPLHVAS 709
Query: 1322 THGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCA 1381
+G+ ++V+ LL A++NA K G++PLH AA+ GH ++V LL ++GASP ++
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769
Query: 1382 PIWFAASENHNDVLEYLLHKEHDTQ-SLMDDK 1412
P+ A + V + L +T L+ DK
Sbjct: 770 PLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801
Score = 298 bits (732), Expect = 1e-79
Identities = 223/743 (30%), Positives = 374/743 (50%), Gaps = 37/743 (4%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G +H A++ GHV ++ LL K ++ TT TALHIA + + VV L+ YGA+
Sbjct: 44 NGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGAN 103
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN---LA 778
V+ + K TPL++AA+ + + LL++GA N ATEDG TP+ VA + G+ +A
Sbjct: 104 VNAQSQK-GFTPLYMAAQ-ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVA 161
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
L+ G L + + T T + PD++ F H
Sbjct: 162 HLINYGTKGKVRLPALHIAARNDDT-RTAAVLLQNDPNPDVLSK-TGFTPLHIAAHYENL 219
Query: 839 FIDAVDEDGASALHYACK--VTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHY 896
+ + + S++++ + +T + + +V+ L++ GA + +T+ + T H
Sbjct: 220 NVAQLLLNRGSSVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPLH- 277
Query: 897 CAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVD 956
CA + ++E++ D + + G +P+ +A H+ V LL A +D
Sbjct: 278 CAARNGHVRISEIL-----LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Query: 957 VFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIR 1016
++ + LH+AA G+ +V LL A NS+A NG T LH+A + +++ L++
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Query: 1017 DHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSE 1076
A ID +T TPLH+A+ G + + K LL+ GA+ + ++ + P+H AA+ ++E
Sbjct: 393 T-GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTE 451
Query: 1077 VVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPL 1136
V + +L Q+ V A KD T H AA G +++ L++ + ++ TPL
Sbjct: 452 VAK-YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT---TAGHTPL 507
Query: 1137 QLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
+AA GH + V L+ AS + G T +H+AA++G V +++ + ++ K
Sbjct: 508 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567
Query: 1197 LGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGN 1256
GLTPLH+A ++ + V+ LL P G S P A +G TPLH+AA
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLL-----------PRGGS--PHSPAWNGYTPLHIAAKQNQ 614
Query: 1257 ENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTG 1316
V R LL G A+A S + G PLHLA GH +V LLLS+ A + ++ G T
Sbjct: 615 VEVARSLLQYGG-SANAESVQ-GVTPLHLAAQEGHAEMVALLLSKQAN-GNLGNKSGLTP 671
Query: 1317 LHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSET 1376
LH+ + GH + +VL+ G ++AT + G+TPLH A+ G++ +VK L + A ++T
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731
Query: 1377 NLNCAPIWFAASENHNDVLEYLL 1399
L +P+ AA + H D++ LL
Sbjct: 732 KLGYSPLHQAAQQGHTDIVTLLL 754
Score = 277 bits (680), Expect = 2e-73
Identities = 231/790 (29%), Positives = 370/790 (46%), Gaps = 63/790 (7%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
++ D A S AAR G++ L+ G ++ + LH+A + +V LL
Sbjct: 7 FREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL- 65
Query: 718 YGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
+ + K+ T LHIAA + D+ L+ GA N ++ G TP+++AA+ +L
Sbjct: 66 HKEIILETTTKKGNTALHIAA-LAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 778 ATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVST 837
+ LLE+G + T+ G TPL +A + ++V HLI + KG+
Sbjct: 125 EVVKFLLENGANQNVATE-------DGFTPLAVALQQGHENVVAHLINY--GTKGKV--- 172
Query: 838 AFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYC 897
ALH A + D + L++N + + ++ T H
Sbjct: 173 ---------RLPALHIAAR---------NDDTRTAAVLLQNDPNPDVLSKTGF-TPLHIA 213
Query: 898 AIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
A N +V ++ S+ + QN I TPL IA RG++ +V LL A+++
Sbjct: 214 AHYENLNVAQLLLNRGSSVN----FTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 958 FDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRD 1017
+ + LH AA +G++++ + LL + A I +K +NG + +H+AA + V+ L++
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ- 326
Query: 1018 HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEV 1077
++A ID +TL TPLH+AA G V K+LL+ GA ++ G P+H A + N+ V
Sbjct: 327 YDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
Query: 1078 VQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
++L L+ + + A T+ G T H+A+ G + +++ L+ + G + + TPL
Sbjct: 387 MELLLKTGAS-IDAVTESGLTPLHVASFMGHLPIVKNLL---QRGASPNVSNVKVETPLH 442
Query: 1138 LAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKL 1197
+AA GH +V + L++ A + + T +H AA GHTN++ ++ N +
Sbjct: 443 MAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA 502
Query: 1198 GLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNE 1257
G TPLHIAA G ETV LL + EA + G TPLH+AA G
Sbjct: 503 GHTPLHIAAREGHVETVLALL-------EKEASQACM------TKKGFTPLHVAAKYGKV 549
Query: 1258 NVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGL 1317
V LLL A+ +NG PLH+A ++ IV LLL R HS +G T L
Sbjct: 550 RVAELLLERDA--HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS-PHSPAWNGYTPL 606
Query: 1318 HIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETN 1377
HIA+ ++ LL G NA G TPLH AA+ GH +V LL A+
Sbjct: 607 HIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNK 666
Query: 1378 LNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVS 1437
P+ A E H V + L+ +H + R Y + + ++ NI + +F+L
Sbjct: 667 SGLTPLHLVAQEGHVPVADVLI--KHGVM-VDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 1438 PAPVDTAAKL 1447
A V+ KL
Sbjct: 724 QADVNAKTKL 733
Score = 225 bits (551), Expect = 1e-57
Identities = 185/597 (30%), Positives = 291/597 (48%), Gaps = 39/597 (6%)
Query: 876 IENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLI 935
+ NG D++ N H + G+ ++ E++ H L G T L I
Sbjct: 32 LRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELL-HKEII-----LETTTKKGNTALHI 84
Query: 936 ACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNG 995
A G ++V L+ A V+ +G + L++AA+ +L+V LL N A N +G
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 996 RTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANI 1055
T L +A G+ ++V LI ++ V + LH+AA + +LL+ N
Sbjct: 145 FTPLAVALQQGHENVVAHLI-NYGTKGKV----RLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 1056 DATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEEL 1115
D + G P+H AA V QL L + + V T ++G T HIA+ +G+V ++ L
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGSS-VNFTPQNGITPLHIASRRGNVIMVRLL 258
Query: 1116 MKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEH 1175
+ DR I + K ++ TPL AA GH + +L+ GA + + GL+ +H+AA+
Sbjct: 259 L--DRGAQIETKTK-DELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 1176 GHTNVLDVMRSTNTLRISSKKLG-LTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVS 1234
H + + ++ + I L LTPLH+AA+ G + LL K P +
Sbjct: 316 DHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHHRVAKVLLD------KGAKPNSRA 368
Query: 1235 LVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSI 1294
L +G TPLH+A + V+ LLL + G DA + E+G PLH+A F GH+ I
Sbjct: 369 L-------NGFTPLHIACKKNHVRVMELLLKT-GASIDAVT-ESGLTPLHVASFMGHLPI 419
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
V LL R A S + +T LH+A+ GH ++ + LL A++NA K+ TPLHCAA
Sbjct: 420 VKNLLQRGASPNVSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRF 1414
+ GH N+VKLL E+ A+P T P+ AA E H + + LL KE +Q+ M K F
Sbjct: 479 RIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE-ASQACMTKKGF 537
Query: 1415 VYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAK--LSNIYINLSTKEKERAKDLIAAG 1469
L V +K + + + E +L A + A K L+ +++ + + K L+ G
Sbjct: 538 T-PLHVAAK-YGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Score = 219 bits (534), Expect = 1e-55
Identities = 170/581 (29%), Positives = 281/581 (48%), Gaps = 42/581 (7%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G +H A+R G+V ++ LL +G ++ T D T LH A + + E LL +GA
Sbjct: 238 NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ + K +P+H+AA+ D C +LL+ A + T D +TP+HVAA G+
Sbjct: 298 IQAK-TKNGLSPIHMAAQ-GDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAK 355
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
+LL+ G P + + G TPL +AC+ ++ L++ + A ID
Sbjct: 356 VLLDKGAKPNSR-------ALNGFTPLHIACKKNHVRVMELLLK----------TGASID 398
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
AV E G + LH A + +P +VK L++ GA ++ + ET H A AG
Sbjct: 399 AVTESGLTPLHVASFMG----HLP-----IVKNLLQRGASPNV-SNVKVETPLHMAARAG 448
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ +V ++ + + + ++A + Q TPL A GH +V LL N+A ++
Sbjct: 449 HTEVAKYLLQNKAKVN-AKAKDDQ-----TPLHCAARIGHTNMVKLLLENNANPNLATTA 502
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM 1021
G + LH+AA G+++ ALL +A + G T LH+AA G + + L+ + +A
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL-ERDAH 561
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
+ TPLH+A +++ KLLL G + + G P+H AA+ N EV +
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L Q+ A + G T H+AA +G +++ L+ G + ++ L TPL L A+
Sbjct: 622 L-QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL---TPLHLVAQ 677
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTP 1201
GH V VL++ G R G T +H+A+ +G+ ++ + + KLG +P
Sbjct: 678 EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSP 737
Query: 1202 LHIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVPVLG 1240
LH AA G + V LL + P V S+ T +++ LG
Sbjct: 738 LHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLG 778
Score = 88.6 bits (210), Expect = 2e-16
Identities = 60/205 (29%), Positives = 98/205 (47%), Gaps = 10/205 (4%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +AV N +V+ LL + A G T LH+AA++ V++AR L+ Y
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN--GYTPLHIAAKQNQVEVARSLLQY 624
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G +A + G TPLH+AA EG +V +AN + + TP+HL A+ GH +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK-------KGVYLHMPNKYFEK 233
++L K + T+ G T +H+AS G+ L + K + P +
Sbjct: 685 DVLI-KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ 743
Query: 234 QTFDEVLFVKIENGLIKGLKSDDGS 258
Q +++ + ++NG S DG+
Sbjct: 744 QGHTDIVTLLLKNGASPNEVSSDGT 768
Score = 86.2 bits (204), Expect = 1e-15
Identities = 52/159 (32%), Positives = 83/159 (52%), Gaps = 2/159 (1%)
Query: 62 RGKVPL-LLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+GKV L L + A N + Q + G T LH+AA ++++A++L++
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G+ V+ T G TPLHIA+ G+ +V+ A ++ TP+H AA NGH I
Sbjct: 229 GSSVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
E+L D A I +TK+G + +H+A+ H DC +L +
Sbjct: 289 EILLD-HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326
Score = 84.2 bits (199), Expect = 4e-15
Identities = 47/154 (30%), Positives = 79/154 (51%), Gaps = 3/154 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL +A G+ + + LL +A G T LH+A ++ V + +L+ GA +D
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNSRALN--GFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
A +G TPLH+A+ G P+VK A+ +++ + TP+H+AA GH + + L
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
KA + + KD T +H A+ GH + +L +
Sbjct: 459 N-KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Score = 82.2 bits (194), Expect = 2e-14
Identities = 56/173 (32%), Positives = 84/173 (48%), Gaps = 3/173 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D V + G PL +A G+ +V+ LL Q + +T LH+AAR ++A+
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLL--QRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+ A V+A QTPLH AA G +VK AN +A TP+H+AA GH
Sbjct: 456 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+ L +K +AS TK G T +H+A+ G A +L ++ + + K
Sbjct: 516 VETVLALLEK-EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567
Score = 77.8 bits (183), Expect = 4e-13
Identities = 59/226 (26%), Positives = 105/226 (46%), Gaps = 10/226 (4%)
Query: 4 SGRDVPRSANINFSSGVRSPPANQQKDLQRLELSFIELNKERAKQKEWKKLIRDLVFQRG 63
+G+D +N+ + V A QK L ++ E + E K +++ + G
Sbjct: 88 AGQDEVVRELVNYGANVN---AQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
PL +A++ G++++V L++ T +++ ALH+AAR D A +L+
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLP------ALHIAARNDDTRTAAVLLQNDPN 198
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
D + G TPLHIAA + + + ++ TP+H+A+ G+ ++ LL
Sbjct: 199 PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGSSVNFTPQNGITPLHIASRRGNVIMVRLL 258
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
D+ A I +TKD T +H A+ NGH + +L G + K
Sbjct: 259 LDR-GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Score = 75.4 bits (177), Expect = 2e-12
Identities = 46/120 (38%), Positives = 68/120 (56%), Gaps = 2/120 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
Q G L LA + G+ MV ELL + L+ TT G+TALH+AA ++ R LV+Y
Sbjct: 43 QNGLNGLHLASKEGHVKMVVELLHKEII--LETTTKKGNTALHIAALAGQDEVVRELVNY 100
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+A + G TPL++AA E +VK+ AN +A + TP+ +A + GH ++
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160
Score = 74.1 bits (174), Expect = 5e-12
Identities = 53/166 (31%), Positives = 84/166 (50%), Gaps = 11/166 (6%)
Query: 661 FDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
++G +H AA+ V + +LLQ G S + + T LH+A + +V LL A
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 721 DVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
+ ++ G K TPLH+ A+ +G A +L+K G + T G TP+HVA+ +GN+
Sbjct: 660 NGNL-GNKSGLTPLHLVAQ--EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIE 825
+ LL+ D KTK+ G +PL A + DIV L++
Sbjct: 717 VKFLLQHQADVNAKTKL-------GYSPLHQAAQQGHTDIVTLLLK 755
Score = 72.5 bits (170), Expect = 1e-11
Identities = 51/163 (31%), Positives = 78/163 (47%), Gaps = 3/163 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL A G+ + E+L A ++A T G + +H+AA+ +D R+L+ Y A +D
Sbjct: 275 PLHCAARNGHVR-ISEILLDHGAP-IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
TPLH+AA G + K A TP+H+A + H ++ELL
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL- 391
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
K ASI T+ G T +H+AS GH L ++G ++ N
Sbjct: 392 KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Score = 64.9 bits (151), Expect = 3e-09
Identities = 49/158 (31%), Positives = 73/158 (46%), Gaps = 3/158 (1%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL A G+ +MV+ LL L ATT AG T LH+AAR V+ L++ A
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNL-ATT-AGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
G TPLH+AA G + + A+ A TP+H+A + + I++LL
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ S +G T +HIA+ + A L + G
Sbjct: 589 LPR-GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 625
Score = 61.7 bits (143), Expect = 3e-08
Identities = 41/154 (26%), Positives = 68/154 (44%), Gaps = 3/154 (1%)
Query: 68 LLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDAT 127
L A +GN + L + + G LHLA++ V M L+ +++ T
Sbjct: 17 LRAARSGNLDKALDHL--RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
Query: 128 NGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKF 187
G T LHIAA G + +V+ AN + TP+++AA+ H +++ L +
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN- 133
Query: 188 KASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
A+ T+DG T + +A GH + L G
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 56.0 bits (129), Expect = 1e-06
Identities = 43/159 (27%), Positives = 74/159 (46%), Gaps = 3/159 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G P+ +A + + VR LL Q ++ T T LH+AA +A++L+D
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLL--QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA ++ G TPLHIA + +++ A+ TP+H+A+ GH I+
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
+ L + + K T +H+A+ GH + A L +
Sbjct: 421 KNLLQRGASPNVSNVK-VETPLHMAARAGHTEVAKYLLQ 458
Score = 52.0 bits (119), Expect = 2e-05
Identities = 32/121 (26%), Positives = 60/121 (49%), Gaps = 2/121 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL L + G+ + L+ + + ATT G T LH+A+ ++ + + L+ + A
Sbjct: 668 GLTPLHLVAQEGHVPVADVLI--KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+A G +PLH AA +G +V A+ ++ TP+ +A G+ ++ ++
Sbjct: 726 DVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDV 785
Query: 183 L 183
L
Sbjct: 786 L 786
Score = 41.5 bits (93), Expect = 0.031
Identities = 28/122 (22%), Positives = 55/122 (45%), Gaps = 1/122 (0%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T+ AAR ++D A + G ++ N G LH+A+ EG +V
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 160 ADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
+ T +H+AA G ++ L + + A++ +++ G T +++A+ H + L +
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Query: 220 KG 221
G
Sbjct: 133 NG 134
>AB209418-1|BAD92655.1| 1899|Homo sapiens ankyrin 1 isoform 4 variant
protein.
Length = 1899
Score = 308 bits (757), Expect = 1e-82
Identities = 232/752 (30%), Positives = 382/752 (50%), Gaps = 63/752 (8%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA+ H+ ++ LL+ G + +V T D +T L +A++ VV L+ YG
Sbjct: 146 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK- 204
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
GK R LHIAAR D + A +LL++ P+ ++ G TP+H+AA + NL L
Sbjct: 205 ----GKVRLPALHIAAR-NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQL 259
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL G + G TPL +A R +VR L++ +G + T
Sbjct: 260 LLNRGAS-------VNFTPQNGITPLHIASRRGNVIMVRLLLD-----RGAQIETK---- 303
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
+D + LH C V+I + L+++GA + +T+ N + H A +
Sbjct: 304 -TKDELTPLH--CAARNGHVRIS-------EILLDHGAPIQAKTK-NGLSPIHMAAQGDH 352
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
D + ++ + + D L+ TPL +A H GH ++ LL A+ + + G
Sbjct: 353 LDCVRLLLQYDAEID-DITLDHL-----TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 406
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+ LH+A + +++V + LL A I++ +G T LH+A+ G+ +VK L++ A
Sbjct: 407 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ-RGASP 465
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
+V +K +TPLH+AA +G EV K LL+ A ++A + Q P+H AA+ ++ +V+L L
Sbjct: 466 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 525
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
+ + N +ATT G+T HIAA +G V+ + L++ + + + TPL +AA+
Sbjct: 526 ENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKEASQACMTKKGF---TPLHVAAKY 581
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
G V +L+ A + GLT +H+A H + +++ ++ S G TPL
Sbjct: 582 GKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPL 641
Query: 1203 HIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRL 1262
HIAA Q E R LL + G+ +E+ GV TPLHLAA G+ +V L
Sbjct: 642 HIAAKQNQVEVARSLLQY-GGSANAESVQGV------------TPLHLAAQEGHAEMVAL 688
Query: 1263 LLNSAGVQADA-ASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIAS 1321
LL+ QA+ N++G PLHL GH+ + +L+ ++ +T R G T LH+AS
Sbjct: 689 LLSK---QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV-MVDATTRMGYTPLHVAS 744
Query: 1322 THGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCA 1381
+G+ ++V+ LL A++NA K G++PLH AA+ GH ++V LL ++GASP ++
Sbjct: 745 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 804
Query: 1382 PIWFAASENHNDVLEYLLHKEHDTQ-SLMDDK 1412
P+ A + V + L +T L+ DK
Sbjct: 805 PLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 836
Score = 297 bits (729), Expect = 3e-79
Identities = 222/743 (29%), Positives = 374/743 (50%), Gaps = 37/743 (4%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G +H A++ GHV ++ LL K ++ TT TALHIA + + VV L+ YGA+
Sbjct: 79 NGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGAN 138
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN---LA 778
V+ + K TPL++AA+ + + LL++GA N ATEDG TP+ VA + G+ +A
Sbjct: 139 VNAQSQK-GFTPLYMAAQ-ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVA 196
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
L+ G L + + T T + PD++ F H
Sbjct: 197 HLINYGTKGKVRLPALHIAARNDDT-RTAAVLLQNDPNPDVLSK-TGFTPLHIAAHYENL 254
Query: 839 FIDAVDEDGASALHYACK--VTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHY 896
+ + + +++++ + +T + + +V+ L++ GA + +T+ + T H
Sbjct: 255 NVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPLH- 312
Query: 897 CAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVD 956
CA + ++E++ D + + G +P+ +A H+ V LL A +D
Sbjct: 313 CAARNGHVRISEIL-----LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 367
Query: 957 VFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIR 1016
++ + LH+AA G+ +V LL A NS+A NG T LH+A + +++ L++
Sbjct: 368 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 427
Query: 1017 DHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSE 1076
A ID +T TPLH+A+ G + + K LL+ GA+ + ++ + P+H AA+ ++E
Sbjct: 428 T-GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTE 486
Query: 1077 VVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPL 1136
V + +L Q+ V A KD T H AA G +++ L++ + ++ TPL
Sbjct: 487 VAK-YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT---TAGHTPL 542
Query: 1137 QLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
+AA GH + V L+ AS + G T +H+AA++G V +++ + ++ K
Sbjct: 543 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 602
Query: 1197 LGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGN 1256
GLTPLH+A ++ + V+ LL P G S P A +G TPLH+AA
Sbjct: 603 NGLTPLHVAVHHNNLDIVKLLL-----------PRGGS--PHSPAWNGYTPLHIAAKQNQ 649
Query: 1257 ENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTG 1316
V R LL G A+A S + G PLHLA GH +V LLLS+ A + ++ G T
Sbjct: 650 VEVARSLLQYGG-SANAESVQ-GVTPLHLAAQEGHAEMVALLLSKQAN-GNLGNKSGLTP 706
Query: 1317 LHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSET 1376
LH+ + GH + +VL+ G ++AT + G+TPLH A+ G++ +VK L + A ++T
Sbjct: 707 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 766
Query: 1377 NLNCAPIWFAASENHNDVLEYLL 1399
L +P+ AA + H D++ LL
Sbjct: 767 KLGYSPLHQAAQQGHTDIVTLLL 789
Score = 277 bits (678), Expect = 4e-73
Identities = 232/792 (29%), Positives = 369/792 (46%), Gaps = 63/792 (7%)
Query: 656 EKYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETL 715
++ K D A S AAR G++ L+ G ++ + LH+A + +V L
Sbjct: 40 DRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 99
Query: 716 LGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
L + + K+ T LHIAA + D+ L+ GA N ++ G TP+++AA+
Sbjct: 100 L-HKEIILETTTKKGNTALHIAA-LAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQEN 157
Query: 776 NLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESV 835
+L + LLE+G + T+ G TPL +A + ++V HLI + KG+
Sbjct: 158 HLEVVKFLLENGANQNVATE-------DGFTPLAVALQQGHENVVAHLINY--GTKGKV- 207
Query: 836 STAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFH 895
ALH A + D + L++N + + ++ T H
Sbjct: 208 -----------RLPALHIAAR---------NDDTRTAAVLLQNDPNPDVLSKTGF-TPLH 246
Query: 896 YCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARV 955
A N +V ++ S QN I TPL IA RG++ +V LL A++
Sbjct: 247 IAAHYENLNVAQLLL----NRGASVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQI 300
Query: 956 DVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLI 1015
+ + + LH AA +G++++ + LL + A I +K +NG + +H+AA + V+ L+
Sbjct: 301 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL 360
Query: 1016 RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYS 1075
+ ++A ID +TL TPLH+AA G V K+LL+ GA ++ G P+H A + N+
Sbjct: 361 Q-YDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHV 419
Query: 1076 EVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTP 1135
V++L L+ + + A T+ G T H+A+ G + +++ L+ + G + + TP
Sbjct: 420 RVMELLLKTGAS-IDAVTESGLTPLHVASFMGHLPIVKNLL---QRGASPNVSNVKVETP 475
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK 1195
L +AA GH +V + L++ A + + T +H AA GHTN++ ++ N +
Sbjct: 476 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 535
Query: 1196 KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNG 1255
G TPLHIAA G ETV LL + EA + G TPLH+AA G
Sbjct: 536 TAGHTPLHIAAREGHVETVLALL-------EKEASQACM------TKKGFTPLHVAAKYG 582
Query: 1256 NENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKT 1315
V LLL A+ +NG PLH+A ++ IV LLL R HS +G T
Sbjct: 583 KVRVAELLLERDA--HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS-PHSPAWNGYT 639
Query: 1316 GLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSE 1375
LHIA+ ++ LL G NA G TPLH AA+ GH +V LL A+
Sbjct: 640 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 699
Query: 1376 TNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVL 1435
P+ A E H V + L+ +H + R Y + + ++ NI + +F+L
Sbjct: 700 NKSGLTPLHLVAQEGHVPVADVLI--KHGVM-VDATTRMGYTPLHVASHYGNIKLVKFLL 756
Query: 1436 VSPAPVDTAAKL 1447
A V+ KL
Sbjct: 757 QHQADVNAKTKL 768
Score = 225 bits (551), Expect = 1e-57
Identities = 185/597 (30%), Positives = 291/597 (48%), Gaps = 39/597 (6%)
Query: 876 IENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLI 935
+ NG D++ N H + G+ ++ E++ H L G T L I
Sbjct: 67 LRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELL-HKEII-----LETTTKKGNTALHI 119
Query: 936 ACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNG 995
A G ++V L+ A V+ +G + L++AA+ +L+V LL N A N +G
Sbjct: 120 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 179
Query: 996 RTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANI 1055
T L +A G+ ++V LI ++ V + LH+AA + +LL+ N
Sbjct: 180 FTPLAVALQQGHENVVAHLI-NYGTKGKV----RLPALHIAARNDDTRTAAVLLQNDPNP 234
Query: 1056 DATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEEL 1115
D + G P+H AA V QL L + + V T ++G T HIA+ +G+V ++ L
Sbjct: 235 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS-VNFTPQNGITPLHIASRRGNVIMVRLL 293
Query: 1116 MKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEH 1175
+ DR I + K ++ TPL AA GH + +L+ GA + + GL+ +H+AA+
Sbjct: 294 L--DRGAQIETKTK-DELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 350
Query: 1176 GHTNVLDVMRSTNTLRISSKKLG-LTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVS 1234
H + + ++ + I L LTPLH+AA+ G + LL K P +
Sbjct: 351 DHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHHRVAKVLLD------KGAKPNSRA 403
Query: 1235 LVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSI 1294
L +G TPLH+A + V+ LLL + G DA + E+G PLH+A F GH+ I
Sbjct: 404 L-------NGFTPLHIACKKNHVRVMELLLKT-GASIDAVT-ESGLTPLHVASFMGHLPI 454
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
V LL R A S + +T LH+A+ GH ++ + LL A++NA K+ TPLHCAA
Sbjct: 455 VKNLLQRGASPNVSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 513
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRF 1414
+ GH N+VKLL E+ A+P T P+ AA E H + + LL KE +Q+ M K F
Sbjct: 514 RIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE-ASQACMTKKGF 572
Query: 1415 VYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAK--LSNIYINLSTKEKERAKDLIAAG 1469
L V +K + + + E +L A + A K L+ +++ + + K L+ G
Sbjct: 573 T-PLHVAAK-YGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 627
Score = 219 bits (534), Expect = 1e-55
Identities = 170/581 (29%), Positives = 281/581 (48%), Gaps = 42/581 (7%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G +H A+R G+V ++ LL +G ++ T D T LH A + + E LL +GA
Sbjct: 273 NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 332
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ + K +P+H+AA+ D C +LL+ A + T D +TP+HVAA G+
Sbjct: 333 IQAK-TKNGLSPIHMAAQ-GDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAK 390
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
+LL+ G P + + G TPL +AC+ ++ L++ + A ID
Sbjct: 391 VLLDKGAKPNSR-------ALNGFTPLHIACKKNHVRVMELLLK----------TGASID 433
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
AV E G + LH A + +P +VK L++ GA ++ + ET H A AG
Sbjct: 434 AVTESGLTPLHVASFMG----HLP-----IVKNLLQRGASPNV-SNVKVETPLHMAARAG 483
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ +V ++ + + + ++A + Q TPL A GH +V LL N+A ++
Sbjct: 484 HTEVAKYLLQNKAKVN-AKAKDDQ-----TPLHCAARIGHTNMVKLLLENNANPNLATTA 537
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM 1021
G + LH+AA G+++ ALL +A + G T LH+AA G + + L+ + +A
Sbjct: 538 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL-ERDAH 596
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
+ TPLH+A +++ KLLL G + + G P+H AA+ N EV +
Sbjct: 597 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 656
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L Q+ A + G T H+AA +G +++ L+ G + ++ L TPL L A+
Sbjct: 657 L-QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL---TPLHLVAQ 712
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTP 1201
GH V VL++ G R G T +H+A+ +G+ ++ + + KLG +P
Sbjct: 713 EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSP 772
Query: 1202 LHIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVPVLG 1240
LH AA G + V LL + P V S+ T +++ LG
Sbjct: 773 LHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLG 813
Score = 88.6 bits (210), Expect = 2e-16
Identities = 60/205 (29%), Positives = 98/205 (47%), Gaps = 10/205 (4%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +AV N +V+ LL + A G T LH+AA++ V++AR L+ Y
Sbjct: 602 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN--GYTPLHIAAKQNQVEVARSLLQY 659
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G +A + G TPLH+AA EG +V +AN + + TP+HL A+ GH +
Sbjct: 660 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 719
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK-------KGVYLHMPNKYFEK 233
++L K + T+ G T +H+AS G+ L + K + P +
Sbjct: 720 DVLI-KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ 778
Query: 234 QTFDEVLFVKIENGLIKGLKSDDGS 258
Q +++ + ++NG S DG+
Sbjct: 779 QGHTDIVTLLLKNGASPNEVSSDGT 803
Score = 87.4 bits (207), Expect = 5e-16
Identities = 53/159 (33%), Positives = 83/159 (52%), Gaps = 2/159 (1%)
Query: 62 RGKVPL-LLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+GKV L L + A N + Q + G T LH+AA ++++A++L++
Sbjct: 204 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 263
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+ T G TPLHIA+ G+ +V+ A ++ TP+H AA NGH I
Sbjct: 264 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 323
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
E+L D A I +TK+G + +H+A+ H DC +L +
Sbjct: 324 EILLD-HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 361
Score = 84.2 bits (199), Expect = 4e-15
Identities = 47/154 (30%), Positives = 79/154 (51%), Gaps = 3/154 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL +A G+ + + LL +A G T LH+A ++ V + +L+ GA +D
Sbjct: 376 PLHVAAHCGHHRVAKVLLDKGAKPNSRALN--GFTPLHIACKKNHVRVMELLLKTGASID 433
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
A +G TPLH+A+ G P+VK A+ +++ + TP+H+AA GH + + L
Sbjct: 434 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 493
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
KA + + KD T +H A+ GH + +L +
Sbjct: 494 N-KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 526
Score = 82.2 bits (194), Expect = 2e-14
Identities = 56/173 (32%), Positives = 84/173 (48%), Gaps = 3/173 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D V + G PL +A G+ +V+ LL Q + +T LH+AAR ++A+
Sbjct: 433 DAVTESGLTPLHVASFMGHLPIVKNLL--QRGASPNVSNVKVETPLHMAARAGHTEVAKY 490
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+ A V+A QTPLH AA G +VK AN +A TP+H+AA GH
Sbjct: 491 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 550
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+ L +K +AS TK G T +H+A+ G A +L ++ + + K
Sbjct: 551 VETVLALLEK-EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 602
Score = 79.0 bits (186), Expect = 2e-13
Identities = 60/226 (26%), Positives = 105/226 (46%), Gaps = 10/226 (4%)
Query: 4 SGRDVPRSANINFSSGVRSPPANQQKDLQRLELSFIELNKERAKQKEWKKLIRDLVFQRG 63
+G+D +N+ + V A QK L ++ E + E K +++ + G
Sbjct: 123 AGQDEVVRELVNYGANVN---AQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 179
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
PL +A++ G++++V L++ T +++ ALH+AAR D A +L+
Sbjct: 180 FTPLAVALQQGHENVVAHLINYGTKGKVRLP------ALHIAARNDDTRTAAVLLQNDPN 233
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
D + G TPLHIAA + + + A+ TP+H+A+ G+ ++ LL
Sbjct: 234 PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 293
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
D+ A I +TKD T +H A+ NGH + +L G + K
Sbjct: 294 LDR-GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 338
Score = 75.4 bits (177), Expect = 2e-12
Identities = 46/120 (38%), Positives = 68/120 (56%), Gaps = 2/120 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
Q G L LA + G+ MV ELL + L+ TT G+TALH+AA ++ R LV+Y
Sbjct: 78 QNGLNGLHLASKEGHVKMVVELLHKEII--LETTTKKGNTALHIAALAGQDEVVRELVNY 135
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+A + G TPL++AA E +VK+ AN +A + TP+ +A + GH ++
Sbjct: 136 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 195
Score = 74.1 bits (174), Expect = 5e-12
Identities = 53/166 (31%), Positives = 84/166 (50%), Gaps = 11/166 (6%)
Query: 661 FDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
++G +H AA+ V + +LLQ G S + + T LH+A + +V LL A
Sbjct: 635 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 694
Query: 721 DVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
+ ++ G K TPLH+ A+ +G A +L+K G + T G TP+HVA+ +GN+
Sbjct: 695 NGNL-GNKSGLTPLHLVAQ--EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 751
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIE 825
+ LL+ D KTK+ G +PL A + DIV L++
Sbjct: 752 VKFLLQHQADVNAKTKL-------GYSPLHQAAQQGHTDIVTLLLK 790
Score = 72.5 bits (170), Expect = 1e-11
Identities = 51/163 (31%), Positives = 78/163 (47%), Gaps = 3/163 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL A G+ + E+L A ++A T G + +H+AA+ +D R+L+ Y A +D
Sbjct: 310 PLHCAARNGHVR-ISEILLDHGAP-IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 367
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
TPLH+AA G + K A TP+H+A + H ++ELL
Sbjct: 368 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL- 426
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
K ASI T+ G T +H+AS GH L ++G ++ N
Sbjct: 427 KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 469
Score = 64.9 bits (151), Expect = 3e-09
Identities = 49/158 (31%), Positives = 73/158 (46%), Gaps = 3/158 (1%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL A G+ +MV+ LL L ATT AG T LH+AAR V+ L++ A
Sbjct: 506 QTPLHCAARIGHTNMVKLLLENNANPNL-ATT-AGHTPLHIAAREGHVETVLALLEKEAS 563
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
G TPLH+AA G + + A+ A TP+H+A + + I++LL
Sbjct: 564 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 623
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ S +G T +HIA+ + A L + G
Sbjct: 624 LPR-GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 660
Score = 64.5 bits (150), Expect = 4e-09
Identities = 49/199 (24%), Positives = 87/199 (43%), Gaps = 5/199 (2%)
Query: 25 ANQQKDLQRLELSFIELNKERAKQ-KEWKKLIRDLVFQR-GKVPLLLAVEAGNQSMVREL 82
A Q K ++ +E ++ KE+ + ++ + RD + L A +GN +
Sbjct: 7 AKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDH 66
Query: 83 LSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEG 142
L + + G LHLA++ V M L+ +++ T G T LHIAA G
Sbjct: 67 L--RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAG 124
Query: 143 DEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLM 202
+ +V+ AN + TP+++AA+ H +++ L + A+ T+DG T +
Sbjct: 125 QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN-GANQNVATEDGFTPL 183
Query: 203 HIASLNGHADCAMMLFKKG 221
+A GH + L G
Sbjct: 184 AVALQQGHENVVAHLINYG 202
Score = 56.0 bits (129), Expect = 1e-06
Identities = 43/159 (27%), Positives = 74/159 (46%), Gaps = 3/159 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G P+ +A + + VR LL Q ++ T T LH+AA +A++L+D
Sbjct: 338 KNGLSPIHMAAQGDHLDCVRLLL--QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 395
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA ++ G TPLHIA + +++ A+ TP+H+A+ GH I+
Sbjct: 396 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 455
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
+ L + + K T +H+A+ GH + A L +
Sbjct: 456 KNLLQRGASPNVSNVK-VETPLHMAARAGHTEVAKYLLQ 493
Score = 52.0 bits (119), Expect = 2e-05
Identities = 32/121 (26%), Positives = 60/121 (49%), Gaps = 2/121 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL L + G+ + L+ + + ATT G T LH+A+ ++ + + L+ + A
Sbjct: 703 GLTPLHLVAQEGHVPVADVLI--KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 760
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+A G +PLH AA +G +V A+ ++ TP+ +A G+ ++ ++
Sbjct: 761 DVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDV 820
Query: 183 L 183
L
Sbjct: 821 L 821
>AB002377-1|BAA20833.2| 1059|Homo sapiens KIAA0379 protein protein.
Length = 1059
Score = 244 bits (596), Expect = 4e-63
Identities = 217/741 (29%), Positives = 337/741 (45%), Gaps = 64/741 (8%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K DG +H A +G T++Q G +D + T LHIA ++ TL+
Sbjct: 308 KSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITS 367
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
GAD RG PLH+AA D C LL SG + + G T +H AA GNL
Sbjct: 368 GADTAKRG-IHGMFPLHLAALSGFSD-CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLE 425
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
L LLL G D +K K G +PL A +C + L+ S A
Sbjct: 426 CLNLLLNTGADFNKKDKF-------GRSPLHYAAANCNYQCLFALVG----------SGA 468
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
++ +DE G + LHYA T + D + ++ L+ N A+ ++ + + A HY A
Sbjct: 469 SVNDLDERGCTPLHYAA--TSD------TDGKCLEYLLRNDANPGIRDKQGYN-AVHYSA 519
Query: 899 IAGNNDVM------TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
G+ + T + + T+ + N +PL +A + GH Q + L+ +
Sbjct: 520 AYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSL 579
Query: 953 ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN-GRTALHLAAMNGYAHLV 1011
+DV + GR+ L LAA G+++ D L+ A I K RT +H AA NG++ +
Sbjct: 580 LDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECL 639
Query: 1012 KFLIRDHNAM--IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA 1069
+ LI + +D+ QTPL L+ +G + LL GAN+DA D+ G+ +H
Sbjct: 640 RLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRG 699
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNK 1129
A + E V LQ ++ ++ G T H++A G + V+ L++ + +
Sbjct: 700 AVTGHEECVDALLQHGAKCLLRDSR-GRTPIHLSAACGHIGVLGALLQSAASMDANPATA 758
Query: 1130 LNDS-TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTN 1188
N T L A GH V +L+ E A + +H A + + +++ T
Sbjct: 759 DNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNA-FSPLHCAVINDNEGAAEMLIDTL 817
Query: 1189 TLRI--SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLT 1246
I ++ G TPLH AA+ E ++ LLSH V S TG T
Sbjct: 818 GASIVNATDSKGRTPLHAAAFTDHVECLQLLLSH-NAQVNSVDSTGK------------T 864
Query: 1247 PLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAE-- 1304
PL +AA NG N V +L++SA + N LHLAC GH + L+L + +
Sbjct: 865 PLMMAAENGQTNTVEMLVSSASAELTLQDNSKN-TALHLACSKGHETSALLILEKITDRN 923
Query: 1305 LLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP-LHCA-----AKAGH 1358
L+++T+ +T LH+A+ +G +V+ LLG+GA + A D+NG+TP L CA A
Sbjct: 924 LINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLA 983
Query: 1359 LNVVKLLCESGASPKSETNLN 1379
L + ++ S +SP S N
Sbjct: 984 LILATMMPVSSSSPLSSLTFN 1004
Score = 233 bits (570), Expect = 5e-60
Identities = 209/741 (28%), Positives = 348/741 (46%), Gaps = 52/741 (7%)
Query: 679 INTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAA 738
+ L+ K E V+ N+ T LH A ++E L+ GA V+ + K TPLH A
Sbjct: 30 VRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWL-TPLHRAV 88
Query: 739 RIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCI 798
++ +LLK A N ++ TP+H+AA A + + PL + V +
Sbjct: 89 -ASCSEEAVQVLLKHSADVNARDKNWQTPLHIAA-----ANKAVKCAEALVPL-LSNVNV 141
Query: 799 YDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVT 858
D G T L A S ++V+ L+ +G A I+A D+ A+H+A +
Sbjct: 142 SD-RAGRTALHHAAFSGHGEMVKLLLS-----RG-----ANINAFDKKDRRAIHWAAYMG 190
Query: 859 KEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADV 918
E VVK L+ +GA+V+ + + ++ T H A +G M ++ ++ D+
Sbjct: 191 HIE---------VVKLLVSHGAEVTCKDKKSY-TPLHAAASSG----MISVVKYL--LDL 234
Query: 919 SRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVC 978
+N N+ G TPL +AC+ G +VN L+ A V+ + +G + LH AA + +C
Sbjct: 235 GVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALC 294
Query: 979 -DALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAA 1037
+ L+ N A +N K+++G+T LH+ A++G + +I+ A+ID TPLH+AA
Sbjct: 295 LELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQS-GAVIDCEDKNGNTPLHIAA 353
Query: 1038 ASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKD-G 1096
G + L+ GA+ G P+H AA + +S+ + L + T D G
Sbjct: 354 RYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSS--GFDIDTPDDFG 411
Query: 1097 NTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGA 1156
TC H AA G+++ + L+ TG + +PL AA + + LV +GA
Sbjct: 412 RTCLHAAAAGGNLECLNLLL---NTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGA 468
Query: 1157 SCTDENRAGLTAVHLAA-EHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
S D + G T +H AA L+ + + K G +H +A YG ++
Sbjct: 469 SVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQ 528
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS 1275
+ S P V E +G ++ + ++PLHLAAY+G+ + +L+ S + D
Sbjct: 529 LIASETPLDVLMET-SGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSL-LDLD-VR 585
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQ 1335
N +G PL LA F GH+ V +L+++ A +L +T +H A+T+GH + + +L+G
Sbjct: 586 NSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGN 645
Query: 1336 GAEINAT---DKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHN 1392
NA D NG TPL + GH + V L GA+ ++ + A H
Sbjct: 646 AEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHE 705
Query: 1393 DVLEYLLHKEHDTQSLMDDKR 1413
+ ++ LL +H + L+ D R
Sbjct: 706 ECVDALL--QHGAKCLLRDSR 724
Score = 232 bits (567), Expect = 1e-59
Identities = 228/778 (29%), Positives = 346/778 (44%), Gaps = 85/778 (10%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA G II L+ G V+ + T LH AV SC V+ LL + ADV+ R
Sbjct: 51 LHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNAR- 109
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
K +TPLHIAA KCA L+ + N + G T +H AA G+ + LLL
Sbjct: 110 DKNWQTPLHIAA-ANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSR 168
Query: 787 GGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDED 846
G + + +D + A ++V+ L+ H E + D+
Sbjct: 169 GAN------INAFD-KKDRRAIHWAAYMGHIEVVKLLV----SHGAE------VTCKDKK 211
Query: 847 GASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVM 906
+ LH A + VVK L++ G D++ + + T H G + V+
Sbjct: 212 SYTPLHAAAS---------SGMISVVKYLLDLGVDMNEPNAYGN-TPLHVACYNGQDVVV 261
Query: 907 TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQL-VNTLLTNHARVDVFDVEGRSA 965
E+I D +N++N G+TPL A H L + L+ N A V++ +G++
Sbjct: 262 NELI------DCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTP 315
Query: 966 LHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVL 1025
LH+ A HG ++ + A I+ + +NG T LH+AA G+ L+ LI A
Sbjct: 316 LHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITS-GADTAKR 374
Query: 1026 TLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQH 1085
+ PLHLAA SG + C+ LL G +ID D+ G+ +HAAA E + L L
Sbjct: 375 GIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTG 434
Query: 1086 PNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLND--STPLQLAAEGG 1143
+ K G + H AA + + + F G ++ N L++ TPL AA
Sbjct: 435 ADF-NKKDKFGRSPLHYAAANCNYQCL-----FALVGSGASVNDLDERGCTPLHYAATSD 488
Query: 1144 -HADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRS------------TNTL 1190
+ L+R A+ ++ G AVH +A +GH L ++ S T+ L
Sbjct: 489 TDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDML 548
Query: 1191 RISSKKLGLTPLHIAAYYGQAET----VRELLSHVPGTVKSEAPTG-------VSLVPVL 1239
S + ++PLH+AAY+G + V+ LL P V V VL
Sbjct: 549 SDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL 608
Query: 1240 ---GAESGL-------TPLHLAAYNGNENVVRLLLNSAGVQ-ADAASNENGYNPLHLACF 1288
GA + TP+H AA NG+ +RLL+ +A Q A + NG PL L+
Sbjct: 609 INQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVL 668
Query: 1289 GGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWT 1348
GH V LL++ A + + D+ G+T LH + GH + V+ LL GA+ D G T
Sbjct: 669 NGHTDCVYSLLNKGAN-VDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRT 727
Query: 1349 PLHCAAKAGHLNVVKLLCESGAS----PKSETNLNCAPIWFAASENHNDVLEYLLHKE 1402
P+H +A GH+ V+ L +S AS P + N + +A H +E LL +E
Sbjct: 728 PIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQE 785
Score = 230 bits (563), Expect = 4e-59
Identities = 230/826 (27%), Positives = 370/826 (44%), Gaps = 81/826 (9%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAV-VETLLGYGAD 721
G +H A G ++N L+ G V+ +T LH A S A+ +E L+G GAD
Sbjct: 245 GNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGAD 304
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V+++ K +TPLH+ A + + +++SGA + ++G TP+H+AA++G+ +
Sbjct: 305 VNMKS-KDGKTPLHMTA-LHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLIN 362
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
L+ G D ++ + G PL +A S D R L+ D ID
Sbjct: 363 TLITSGADTAKRG-------IHGMFPLHLAALSGFSDCCRKLLSSGFD----------ID 405
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
D+ G + LH A + + + L+ GAD + + + + HY A
Sbjct: 406 TPDDFGRTCLHAAAA---------GGNLECLNLLLNTGADFNKKDKFGR-SPLHYAAANC 455
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRG-HMQLVNTLLTNHARVDVFDV 960
N + ++ S A V N + G TPL A + + LL N A + D
Sbjct: 456 NYQCLFALVG--SGASV----NDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDK 509
Query: 961 EGRSALHLAAEHGY---LQVC------DALL-TNKAFINSKARNGRTA--LHLAAMNGYA 1008
+G +A+H +A +G+ LQ+ D L+ T+ + S + N T LHLAA +G+
Sbjct: 510 QGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHH 569
Query: 1009 HLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDE-LGQKPIH 1067
++ L++ +DV +TPL LAA G +E +L+ GA+I D L + PIH
Sbjct: 570 QALEVLVQSL-LDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIH 628
Query: 1068 AAAQNNYSEVVQLFL--QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVIS 1125
AAA N +SE ++L + + N V +G T ++ + G + L+ ++ +
Sbjct: 629 AAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLL--NKGANVD 686
Query: 1126 ARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM- 1184
A++K T L A GH + V L++ GA C + G T +HL+A GH VL +
Sbjct: 687 AKDKWG-RTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALL 745
Query: 1185 ---RSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGA 1241
S + ++ G T LH A Y G ET ELL K+E
Sbjct: 746 QSAASMDANPATADNHGYTALHWACYNGH-ETCVELLLEQEVFQKTEG------------ 792
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+ +PLH A N NE +L+++ G A++ G PLH A F H+ + LLLS
Sbjct: 793 -NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSH 851
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLN 1360
+A++ +S D GKT L +A+ +G VE+L+ AE+ D + T LH A GH
Sbjct: 852 NAQV-NSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHET 910
Query: 1361 VVKLLCESGASPKSETNLNCA---PIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYN 1417
L+ E N A P+ AA V++ LL K L D+
Sbjct: 911 SALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGK--GASVLAVDENGYTP 968
Query: 1418 LMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKERAK 1463
+ C+ N + +L + PV +++ LS++ N + +K
Sbjct: 969 ALACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAINRYTNTSK 1014
Score = 227 bits (554), Expect = 4e-58
Identities = 222/782 (28%), Positives = 358/782 (45%), Gaps = 75/782 (9%)
Query: 665 RSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHI 724
R+IH AA GH+ ++ L+ G V +YT LH A S +VV+ LL G D++
Sbjct: 181 RAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN- 239
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA-TLVLL 783
TPLH+A D L+ GA N+ E G TP+H AA + A L LL
Sbjct: 240 EPNAYGNTPLHVAC-YNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELL 298
Query: 784 LEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAV 843
+ +G D K+K G+TPL M + +I+ S A ID
Sbjct: 299 VGNGADVNMKSK-------DGKTPLHMTALHGRFSRSQTIIQ----------SGAVIDCE 341
Query: 844 DEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN 903
D++G + LH A + E ++ LI +GAD + + H H A++G +
Sbjct: 342 DKNGNTPLHIAARYGHE---------LLINTLITSGADTAKRGIHG-MFPLHLAALSGFS 391
Query: 904 DVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGR 963
D ++++ S D+ + + G T L A G+++ +N LL A + D GR
Sbjct: 392 DCCRKLLS--SGFDI----DTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGR 445
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY-AHLVKFLIRDHNAMI 1022
S LH AA + Q AL+ + A +N G T LH AA + +++L+R ++A
Sbjct: 446 SPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLR-NDANP 504
Query: 1023 DVLTLKKQTPLHLAAASG-----QIEVCKLLLELGANIDATDELGQ-------KPIHAAA 1070
+ + +H +AA G Q+ + L++ TD L P+H AA
Sbjct: 505 GIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAA 564
Query: 1071 QNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKL 1130
+ + + +++ +Q +L + + G T +AA +G V+ ++ L+ ++ I ++ +
Sbjct: 565 YHGHHQALEVLVQSLLDLDVRNS-SGRTPLDLAAFKGHVECVDVLI--NQGASILVKDYI 621
Query: 1131 NDSTPLQLAAEGGHADVVRVLV--RAGASCTD-ENRAGLTAVHLAAEHGHTNVLDVMRST 1187
TP+ AA GH++ +R+L+ + D ++ G T + L+ +GHT+ + + +
Sbjct: 622 LKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNK 681
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+ K G T LH A G E V LL H G +L G TP
Sbjct: 682 GANVDAKDKWGRTALHRGAVTGHEECVDALLQH-----------GAKC--LLRDSRGRTP 728
Query: 1248 LHLAAYNGNENVVRLLLNS-AGVQADAASNEN-GYNPLHLACFGGHMSIVGLLLSRSAEL 1305
+HL+A G+ V+ LL S A + A+ A+ +N GY LH AC+ GH + V LLL + E+
Sbjct: 729 IHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ--EV 786
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQ-GAEI-NATDKNGWTPLHCAAKAGHLNVVK 1363
T+ + + LH A + + E+L+ GA I NATD G TPLH AA H+ ++
Sbjct: 787 FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQ 846
Query: 1364 LLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSK 1423
LL A S + P+ AA + +E L+ +L D+ + + CSK
Sbjct: 847 LLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSK 906
Query: 1424 NH 1425
H
Sbjct: 907 GH 908
Score = 219 bits (536), Expect = 7e-56
Identities = 212/747 (28%), Positives = 335/747 (44%), Gaps = 63/747 (8%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA V L+ +V+V+ TALH A S +V+ LL GA+++
Sbjct: 117 LHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFD 176
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
K R +H AA + + L L+ GA + TP+H AA G ++ + LL+
Sbjct: 177 KKDRRA-IHWAAYMGHIEVVKL-LVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDL 234
Query: 787 GGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDED 846
G D G TPL +AC + +V LI+ A ++ +E
Sbjct: 235 GVDMNEPN-------AYGNTPLHVACYNGQDVVVNELID----------CGAIVNQKNEK 277
Query: 847 GASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVM 906
G + LH+A T + ++ L+ NGADV+++++ + +T H A+ G
Sbjct: 278 GFTPLHFAAASTHGAL--------CLELLVGNGADVNMKSK-DGKTPLHMTALHGRFSRS 328
Query: 907 TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSAL 966
+I + D ++ G TPL IA GH L+NTL+T+ A + G L
Sbjct: 329 QTIIQSGAVIDC------EDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPL 382
Query: 967 HLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
HLAA G+ C LL++ I++ GRT LH AA G + L+ + A +
Sbjct: 383 HLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLL-NTGADFNKKD 441
Query: 1027 LKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP 1086
++PLH AAA+ + L+ GA+++ DE G P+H AA ++ +L ++
Sbjct: 442 KFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRND 501
Query: 1087 NLVMATTKDGNTCAHIAAIQG---------SVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
K G H +A G S ++ LM+ T ++S + +PL
Sbjct: 502 ANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLH 561
Query: 1138 LAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTN-TLRISSKK 1196
LAA GH + VLV++ N +G T + LAA GH +DV+ + ++ +
Sbjct: 562 LAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYI 621
Query: 1197 LGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGN 1256
L TP+H AA G +E +R L+ + +E V + +G TPL L+ NG+
Sbjct: 622 LKRTPIHAAATNGHSECLRLLIGN------AEPQNAVDIQD----GNGQTPLMLSVLNGH 671
Query: 1257 ENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTG 1316
+ V LLN G D A ++ G LH GH V LL A+ L D G+T
Sbjct: 672 TDCVYSLLNK-GANVD-AKDKWGRTALHRGAVTGHEECVDALLQHGAKCL-LRDSRGRTP 728
Query: 1317 LHIASTHGHYQMVEVLLGQGAEINA----TDKNGWTPLHCAAKAGHLNVVKLLCESGASP 1372
+H+++ GH ++ LL A ++A D +G+T LH A GH V+LL E
Sbjct: 729 IHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQ 788
Query: 1373 KSETNLNCAPIWFAASENHNDVLEYLL 1399
K+E N +P+ A ++ E L+
Sbjct: 789 KTEGNA-FSPLHCAVINDNEGAAEMLI 814
Score = 185 bits (450), Expect = 2e-45
Identities = 147/493 (29%), Positives = 230/493 (46%), Gaps = 32/493 (6%)
Query: 933 LLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKA 992
L+ A G V L+ V+ D E R+ LH AA G ++ + L+ + A +N+K
Sbjct: 18 LVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKD 77
Query: 993 RNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELG 1052
T LH A + V+ L++ H+A ++ QTPLH+AAA+ ++ + L+ L
Sbjct: 78 SKWLTPLHRAVASCSEEAVQVLLK-HSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 136
Query: 1053 ANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVI 1112
+N++ +D G+ +H AA + + E+V+L L + N + A K H AA G ++V+
Sbjct: 137 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGAN-INAFDKKDRRAIHWAAYMGHIEVV 195
Query: 1113 EELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA 1172
+ L+ ++ ++K TPL AA G VV+ L+ G + N G T +H+A
Sbjct: 196 KLLV--SHGAEVTCKDK-KSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVA 252
Query: 1173 AEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK------ 1226
+G V++ + + + G TPLH AA ELL V
Sbjct: 253 CYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDG 312
Query: 1227 -------------SEAPTGVSLVPVLGAE--SGLTPLHLAAYNGNENVVRLLLNSAGVQA 1271
S + T + V+ E +G TPLH+AA G+E ++ L+ S A
Sbjct: 313 KTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSG---A 369
Query: 1272 DAASNE-NGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVE 1330
D A +G PLHLA G LLS + + + D G+T LH A+ G+ + +
Sbjct: 370 DTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFD-IDTPDDFGRTCLHAAAAGGNLECLN 428
Query: 1331 VLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAA-SE 1389
+LL GA+ N DK G +PLH AA + + L SGAS C P+ +AA S+
Sbjct: 429 LLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSD 488
Query: 1390 NHNDVLEYLLHKE 1402
LEYLL +
Sbjct: 489 TDGKCLEYLLRND 501
Score = 178 bits (433), Expect = 2e-43
Identities = 177/707 (25%), Positives = 312/707 (44%), Gaps = 54/707 (7%)
Query: 703 AVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATE 762
A+ + P V L+ DV+ + ++R TPLH AA + D + L++L SGA N
Sbjct: 21 AIFNGDPDEVRALIFKKEDVNFQDNEKR-TPLHAAAYLGDAEIIELLIL-SGARVNAKDS 78
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
+TP+H A + + +LL+ D + K +TPL +A +
Sbjct: 79 KWLTPLHRAVASCSEEAVQVLLKHSADVNARDK-------NWQTPLHIAAANKAVKCAEA 131
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L+ + + ++ D G +ALH+A + ++VK L+ GA++
Sbjct: 132 LVPLLSN----------VNVSDRAGRTALHHAAF---------SGHGEMVKLLLSRGANI 172
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ + + A H+ A G+ +V+ +++H A+V+ ++ +TPL A G +
Sbjct: 173 NAFDKKDRR-AIHWAAYMGHIEVVKLLVSH--GAEVTC----KDKKSYTPLHAAASSGMI 225
Query: 943 QLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLA 1002
+V LL ++ + G + LH+A +G V + L+ A +N K G T LH A
Sbjct: 226 SVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFA 285
Query: 1003 AMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELG 1062
A + + L L+ + A +++ + +TPLH+ A G+ + +++ GA ID D+ G
Sbjct: 286 AASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNG 345
Query: 1063 QKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMK--FDR 1120
P+H AA+ + ++ + + G H+AA+ G +L+ FD
Sbjct: 346 NTPLHIAARYGHELLINTLITSGADTAKRGI-HGMFPLHLAALSGFSDCCRKLLSSGFD- 403
Query: 1121 TGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNV 1180
I + T L AA GG+ + + +L+ GA +++ G + +H AA + +
Sbjct: 404 ---IDTPDDFG-RTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQC 459
Query: 1181 LDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLG 1240
L + + + G TPLH AA E L G + V
Sbjct: 460 LFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSA 519
Query: 1241 AESGLTPLHLAAYNGNENVVRLLLNSAGV-QADAASNENGYNPLHLACFGGHMSIVGLLL 1299
A L L A +E + +L+ ++G + N +PLHLA + GH + +L+
Sbjct: 520 AYGHRLCLQLIA---SETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLV 576
Query: 1300 SRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDK-NGWTPLHCAAKAGH 1358
+ L + G+T L +A+ GH + V+VL+ QGA I D TP+H AA GH
Sbjct: 577 QSLLD-LDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGH 635
Query: 1359 LNVVKLLCESGASPKSETNL----NCAPIWFAASENHNDVLEYLLHK 1401
++LL A P++ ++ P+ + H D + LL+K
Sbjct: 636 SECLRLLI-GNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNK 681
Score = 144 bits (349), Expect = 3e-33
Identities = 119/400 (29%), Positives = 184/400 (46%), Gaps = 26/400 (6%)
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
L L+ Q L A +G + + L+ +++ D + P+HAAA +E+++L +
Sbjct: 10 LKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILS 69
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
V A T H A S + ++ L+K + ++AR+K N TPL +AA
Sbjct: 70 GAR-VNAKDSKWLTPLHRAVASCSEEAVQVLLK--HSADVNARDK-NWQTPLHIAAANKA 125
Query: 1145 ADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHI 1204
LV ++ +RAG TA+H AA GH ++ ++ S + K +H
Sbjct: 126 VKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHW 185
Query: 1205 AAYYGQAETVRELLSH-VPGTVKSE---------APTG-VSLVPV---LGAES------G 1244
AAY G E V+ L+SH T K + A +G +S+V LG + G
Sbjct: 186 AAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYG 245
Query: 1245 LTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAE 1304
TPLH+A YNG + VV L++ + NE G+ PLH A H ++ LL +
Sbjct: 246 NTPLHVACYNGQDVVVNELIDCGAIVNQ--KNEKGFTPLHFAAASTHGALCLELLVGNGA 303
Query: 1305 LLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKL 1364
++ + GKT LH+ + HG + + ++ GA I+ DKNG TPLH AA+ GH ++
Sbjct: 304 DVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINT 363
Query: 1365 LCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
L SGA P+ AA +D LL D
Sbjct: 364 LITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFD 403
Score = 72.9 bits (171), Expect = 1e-11
Identities = 51/174 (29%), Positives = 79/174 (45%), Gaps = 6/174 (3%)
Query: 54 LIRDLVFQRGKVPLLLAVEAGNQSMVRELL-SAQTAEQLKATTPAGDTALHLAARRRDVD 112
L++D + +R P+ A G+ +R L+ +A+ + G T L L+ D
Sbjct: 616 LVKDYILKR--TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTD 673
Query: 113 MARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA 172
L++ GA VDA + G+T LH A G E V A + D+ RTP+HL+A
Sbjct: 674 CVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSA 733
Query: 173 ENGHAAIIELL---ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
GH ++ L A A+ G T +H A NGH C +L ++ V+
Sbjct: 734 ACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVF 787
Score = 72.5 bits (170), Expect = 1e-11
Identities = 52/165 (31%), Positives = 79/165 (47%), Gaps = 3/165 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL AV + ++ V+ LL + + + A T LH+AA + V A LV + V+
Sbjct: 83 PLHRAVASCSEEAVQVLL--KHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVN 140
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
++ AG+T LH AA G +VK AN D +DR +H AA GH +++LL
Sbjct: 141 VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLV- 199
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
A + + K T +H A+ +G L GV ++ PN Y
Sbjct: 200 SHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAY 244
Score = 71.7 bits (168), Expect = 3e-11
Identities = 49/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L A +G+ MV+ LLS + A A+H AA +++ ++LV +GA
Sbjct: 146 GRTALHHAAFSGHGEMVKLLLSR--GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA 203
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V + TPLH AA+ G +VKY + + + TP+H+A NG ++
Sbjct: 204 EVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNE 263
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGH-ADCAMMLFKKGVYLHMPNK 229
L D A + ++ + G T +H A+ + H A C +L G ++M +K
Sbjct: 264 LID-CGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSK 310
Score = 70.1 bits (164), Expect = 8e-11
Identities = 49/171 (28%), Positives = 80/171 (46%), Gaps = 4/171 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL A + + ++ ELL A+ + + G T LH+ A ++ ++
Sbjct: 276 EKGFTPLHFAAASTHGALCLELLVGNGAD-VNMKSKDGKTPLHMTALHGRFSRSQTIIQS 334
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA-AI 179
GAV+D + G TPLHIAA G E L+ A+ A P+HLAA +G +
Sbjct: 335 GAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCC 394
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
+LL+ F I G T +H A+ G+ +C +L G + +K+
Sbjct: 395 RKLLSSGF--DIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKF 443
Score = 68.1 bits (159), Expect = 3e-10
Identities = 48/160 (30%), Positives = 77/160 (48%), Gaps = 5/160 (3%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVD-YG 121
G L A G+++ V ELL Q E + T + LH A + A +L+D G
Sbjct: 762 GYTALHWACYNGHETCV-ELLLEQ--EVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLG 818
Query: 122 A-VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A +V+AT+ G+TPLH AA ++ A D+ +TP+ +AAENG +
Sbjct: 819 ASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTV 878
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
E+L A + + +T +H+A GH A+++ +K
Sbjct: 879 EMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEK 918
Score = 67.7 bits (158), Expect = 4e-10
Identities = 43/132 (32%), Positives = 63/132 (47%), Gaps = 3/132 (2%)
Query: 102 LHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIAD 161
LHLAA +LV +D N +G+TPL +AA +G V A+ + D
Sbjct: 560 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 619
Query: 162 NE-DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGS--TLMHIASLNGHADCAMMLF 218
RTP+H AA NGH+ + LL + +DG+ T + ++ LNGH DC L
Sbjct: 620 YILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLL 679
Query: 219 KKGVYLHMPNKY 230
KG + +K+
Sbjct: 680 NKGANVDAKDKW 691
Score = 67.3 bits (157), Expect = 6e-10
Identities = 38/131 (29%), Positives = 65/131 (49%), Gaps = 2/131 (1%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T LH AA + + + L+D G ++ N G TPLH+A G + +V A
Sbjct: 214 TPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQ 273
Query: 160 ADNEDRTPMHLAAENGHAAI-IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF 218
+ + TP+H AA + H A+ +ELL A + ++KDG T +H+ +L+G + +
Sbjct: 274 KNEKGFTPLHFAAASTHGALCLELLVGN-GADVNMKSKDGKTPLHMTALHGRFSRSQTII 332
Query: 219 KKGVYLHMPNK 229
+ G + +K
Sbjct: 333 QSGAVIDCEDK 343
Score = 63.7 bits (148), Expect = 7e-09
Identities = 58/216 (26%), Positives = 101/216 (46%), Gaps = 16/216 (7%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL A G+ ++ ELL A ++ A T LH A + ++L+ + A
Sbjct: 48 RTPLHAAAYLGDAEII-ELLILSGA-RVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSAD 105
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
V+A + QTPLHIAAA + + +N ++D RT +H AA +GH +++LL
Sbjct: 106 VNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLL 165
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDEVLFVK 243
+ A+I K +H A+ GH + +L G + +K+++ L
Sbjct: 166 LSR-GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK----DKKSYTP-LHAA 219
Query: 244 IENGLIKGLKSDDGSYSMFLGIPYALVNESNPFGDS 279
+G+I +K Y + LG+ +NE N +G++
Sbjct: 220 ASSGMISVVK-----YLLDLGVD---MNEPNAYGNT 247
Score = 61.7 bits (143), Expect = 3e-08
Identities = 41/119 (34%), Positives = 61/119 (51%), Gaps = 4/119 (3%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
GK PL++A E G + V L+S+ +AE L + +TALHLA + A ++++
Sbjct: 862 GKTPLMMAAENGQTNTVEMLVSSASAE-LTLQDNSKNTALHLACSKGHETSALLILEKIT 920
Query: 123 ---VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
+++ATN A QTPLH+AA G +V+ G A+ D TP A N A
Sbjct: 921 DRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVA 979
Score = 52.4 bits (120), Expect = 2e-05
Identities = 42/146 (28%), Positives = 68/146 (46%), Gaps = 3/146 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A G++ ++ L+++ A+ K G LHLAA D R L+
Sbjct: 343 KNGNTPLHIAARYGHELLINTLITSG-ADTAKRGIH-GMFPLHLAALSGFSDCCRKLLSS 400
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G +D + G+T LH AAA G+ + A+ D R+P+H AA N + +
Sbjct: 401 GFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCL 460
Query: 181 ELLADKFKASIFERTKDGSTLMHIAS 206
L AS+ + + G T +H A+
Sbjct: 461 FALVGS-GASVNDLDERGCTPLHYAA 485
Score = 52.0 bits (119), Expect = 2e-05
Identities = 30/116 (25%), Positives = 56/116 (48%)
Query: 102 LHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIAD 161
L L A +D+ + D+ N A +PLH+AA G ++ + + +
Sbjct: 527 LQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRN 586
Query: 162 NEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+ RTP+ LAA GH +++L ++ + + + T +H A+ NGH++C +L
Sbjct: 587 SSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLL 642
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/110 (31%), Positives = 53/110 (48%), Gaps = 5/110 (4%)
Query: 110 DVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTP 167
D D R L+ V+ + +TPLH AA GD +++ G R NA D++ TP
Sbjct: 26 DPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNA--KDSKWLTP 83
Query: 168 MHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+H A + +++L K A + R K+ T +HIA+ N CA L
Sbjct: 84 LHRAVASCSEEAVQVLL-KHSADVNARDKNWQTPLHIAAANKAVKCAEAL 132
Score = 42.7 bits (96), Expect = 0.014
Identities = 42/161 (26%), Positives = 70/161 (43%), Gaps = 8/161 (4%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G+ PL A + ++ LLS Q+ + G T L +AA + +LV
Sbjct: 828 KGRTPLHAAAFTDHVECLQLLLSHNA--QVNSVDSTGKTPLMMAAENGQTNTVEMLVSSA 885
Query: 122 -AVVDATNGAGQTPLHIAAAEGDEPLVKYFYG--VRANAAIADNED-RTPMHLAAENGHA 177
A + + + T LH+A ++G E N A N +TP+H+AA NG
Sbjct: 886 SAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLT 945
Query: 178 AIIELLADKFKASIFERTKDGST-LMHIASLNGHADCAMML 217
+++ L K AS+ ++G T + A ADC ++
Sbjct: 946 MVVQELLGK-GASVLAVDENGYTPALACAPNKDVADCLALI 985
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/102 (25%), Positives = 46/102 (45%), Gaps = 2/102 (1%)
Query: 1323 HGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAP 1382
+G V L+ + ++N D TPLH AA G +++LL SGA ++ + P
Sbjct: 24 NGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTP 83
Query: 1383 IWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKN 1424
+ A + + ++ LL +H DK + L + + N
Sbjct: 84 LHRAVASCSEEAVQVLL--KHSADVNARDKNWQTPLHIAAAN 123
Score = 36.3 bits (80), Expect = 1.2
Identities = 22/52 (42%), Positives = 26/52 (50%)
Query: 132 QTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
Q L A GD V+ + + DNE RTP+H AA G A IIELL
Sbjct: 15 QPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELL 66
>U43965-1|AAB08437.1| 1088|Homo sapiens ankyrin G119 protein.
Length = 1088
Score = 219 bits (536), Expect = 7e-56
Identities = 140/431 (32%), Positives = 222/431 (51%), Gaps = 22/431 (5%)
Query: 978 CDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAA 1037
CD LL KA N+KA NG T LH+A +++ L++ H A I +T TP+H+AA
Sbjct: 5 CD-LLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLK-HGASIQAVTESGLTPIHVAA 62
Query: 1038 ASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGN 1097
G + + L+ GA+ + T+ G+ +H AA++ +EVV+ +L Q V A KD
Sbjct: 63 FMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVR-YLVQDGAQVEAKAKDDQ 121
Query: 1098 TCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGAS 1157
T HI+A G ++++L++ G + TPL L+A GH DV L+ GAS
Sbjct: 122 TPLHISARLGKADIVQQLLQ---QGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGAS 178
Query: 1158 CTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVREL 1217
+ + G T +H+AA++G V +++ + ++ K GLTPLH+AA+Y + L
Sbjct: 179 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 238
Query: 1218 LSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNE 1277
L G S P A++G TPLH+AA ++ LL G A+A + +
Sbjct: 239 LDQ-----------GAS--PHAAAKNGYTPLHIAAKKNQMDIATTLLEY-GADANAVTRQ 284
Query: 1278 NGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGA 1337
G +HLA GH+ +V LLL R+A + + +++ G T LH+A+ + EVL+ QGA
Sbjct: 285 -GIASVHLAAQEGHVDMVSLLLGRNANV-NLSNKSGLTPLHLAAQEDRVNVAEVLVNQGA 342
Query: 1338 EINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEY 1397
++A K G+TPLH G++ +V L + A ++T P+ AA + H ++
Sbjct: 343 HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINV 402
Query: 1398 LLHKEHDTQSL 1408
LL L
Sbjct: 403 LLQNNASPNEL 413
Score = 213 bits (520), Expect = 6e-54
Identities = 140/437 (32%), Positives = 227/437 (51%), Gaps = 21/437 (4%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G+TPL IAC + ++++ LL + A + G + +H+AA G++ + L+ + A
Sbjct: 21 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP 80
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N+ G TALH+AA +G A +V++L++D A ++ QTPLH++A G+ ++ + L
Sbjct: 81 NTTNVRGETALHMAARSGQAEVVRYLVQD-GAQVEAKAKDDQTPLHISARLGKADIVQQL 139
Query: 1049 LELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGS 1108
L+ GA+ +A G P+H +A+ + +V FL H + TTK G T H+AA G
Sbjct: 140 LQQGASPNAATTSGYTPLHLSAREGHEDVAA-FLLDHGASLSITTKKGFTPLHVAAKYGK 198
Query: 1109 VKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTA 1168
++V L++ + + ++ L TPL +AA + V +L+ GAS + G T
Sbjct: 199 LEVANLLLQKSASPDAAGKSGL---TPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTP 255
Query: 1169 VHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSE 1228
+H+AA+ ++ + + + G+ +H+AA G + V LL
Sbjct: 256 LHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL---------- 305
Query: 1229 APTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACF 1288
G + L +SGLTPLHLAA NV +L+N G DA + + GY PLH+ C
Sbjct: 306 ---GRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQ-GAHVDAQT-KMGYTPLHVGCH 360
Query: 1289 GGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWT 1348
G++ IV LL SA++ T ++G T LH A+ GH ++ VLL A N NG T
Sbjct: 361 YGNIKIVNFLLQHSAKVNAKT-KNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNT 419
Query: 1349 PLHCAAKAGHLNVVKLL 1365
L A + G+++VV L
Sbjct: 420 ALGIARRLGYISVVDTL 436
Score = 206 bits (503), Expect = 7e-52
Identities = 141/436 (32%), Positives = 231/436 (52%), Gaps = 23/436 (5%)
Query: 942 MQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
M L LL A + + G + LH+A + ++V + LL + A I + +G T +H+
Sbjct: 1 MNLRCDLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHV 60
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
AA G+ ++V L+ H A + ++ +T LH+AA SGQ EV + L++ GA ++A +
Sbjct: 61 AAFMGHVNIVSQLMH-HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKD 119
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
Q P+H +A+ +++VQ LQQ + ATT G T H++A +G V L+ D
Sbjct: 120 DQTPLHISARLGKADIVQQLLQQGASPNAATT-SGYTPLHLSAREGHEDVAAFLL--DHG 176
Query: 1122 GVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVL 1181
+S K TPL +AA+ G +V +L++ AS ++GLT +H+AA + + V
Sbjct: 177 ASLSITTK-KGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVA 235
Query: 1182 DVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGA 1241
++ ++ K G TPLHIAA Q + LL + G V
Sbjct: 236 LLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEY-----------GADANAV--T 282
Query: 1242 ESGLTPLHLAAYNGNENVVRLLL-NSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLS 1300
G+ +HLAA G+ ++V LLL +A V SN++G PLHLA +++ +L++
Sbjct: 283 RQGIASVHLAAQEGHVDMVSLLLGRNANVN---LSNKSGLTPLHLAAQEDRVNVAEVLVN 339
Query: 1301 RSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
+ A + T + G T LH+ +G+ ++V LL A++NA KNG+TPLH AA+ GH +
Sbjct: 340 QGAHVDAQT-KMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTH 398
Query: 1361 VVKLLCESGASPKSET 1376
++ +L ++ ASP T
Sbjct: 399 IINVLLQNNASPNELT 414
Score = 200 bits (488), Expect = 4e-50
Identities = 151/502 (30%), Positives = 249/502 (49%), Gaps = 42/502 (8%)
Query: 846 DGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDV 905
+G + LH ACK K +K V++ L+++GA + T T H A G+ ++
Sbjct: 20 NGFTPLHIACK--KNRIK-------VMELLLKHGASIQAVTESGL-TPIHVAAFMGHVNI 69
Query: 906 MTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSA 965
+++++ H ++ N N G T L +A G ++V L+ + A+V+ + ++
Sbjct: 70 VSQLMHHGASP------NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 123
Query: 966 LHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVL 1025
LH++A G + LL A N+ +G T LHL+A G+ + FL+ DH A + +
Sbjct: 124 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLL-DHGASLSIT 182
Query: 1026 TLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQH 1085
T K TPLH+AA G++EV LLL+ A+ DA + G P+H AA + +V L L Q
Sbjct: 183 TKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQG 242
Query: 1086 PNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA 1145
+ A K+G T HIAA + + + L+++ R + + LAA+ GH
Sbjct: 243 AS-PHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGI---ASVHLAAQEGHV 298
Query: 1146 DVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIA 1205
D+V +L+ A+ N++GLT +HLAA+ NV +V+ + + K+G TPLH+
Sbjct: 299 DMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVG 358
Query: 1206 AYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLN 1265
+YG + V LL H + K A T ++G TPLH AA G+ +++ +LL
Sbjct: 359 CHYGNIKIVNFLLQH---SAKVNAKT----------KNGYTPLHQAAQQGHTHIINVLL- 404
Query: 1266 SAGVQADAASNE---NGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIAST 1322
Q +A+ NE NG L +A G++S+V L + E + +T K +++ T
Sbjct: 405 ----QNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPET 460
Query: 1323 HGHYQMVEVLLGQGAEINATDK 1344
+ G+ A TDK
Sbjct: 461 MNEVLDMSDDEGEDAMTGDTDK 482
Score = 186 bits (454), Expect = 6e-46
Identities = 136/454 (29%), Positives = 228/454 (50%), Gaps = 39/454 (8%)
Query: 732 TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPL 791
TPLHIA + + K +LLK GA TE G+TP+HVAA G++ + L+ G P
Sbjct: 23 TPLHIACK-KNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPN 81
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
V GET L MA RS ++VR+L++ A ++A +D + L
Sbjct: 82 TTN-------VRGETALHMAARSGQAEVVRYLVQ----------DGAQVEAKAKDDQTPL 124
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIA 911
H + ++ K + +V+ L++ GA + T + T H A G+ DV ++
Sbjct: 125 HISARLGKAD---------IVQQLLQQGASPNAATTSGY-TPLHLSAREGHEDVAAFLLD 174
Query: 912 HISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAE 971
H +L+ G+TPL +A G +++ N LL A D G + LH+AA
Sbjct: 175 H------GASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAH 228
Query: 972 HGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQT 1031
+ +V LL A ++ A+NG T LH+AA + L+ ++ A + +T +
Sbjct: 229 YDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLL-EYGADANAVTRQGIA 287
Query: 1032 PLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
+HLAA G +++ LLL AN++ +++ G P+H AAQ + V ++ + Q + V A
Sbjct: 288 SVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAH-VDA 346
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
TK G T H+ G++K++ L++ + ++A+ K N TPL AA+ GH ++ VL
Sbjct: 347 QTKMGYTPLHVGCHYGNIKIVNFLLQ--HSAKVNAKTK-NGYTPLHQAAQQGHTHIINVL 403
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMR 1185
++ AS + G TA+ +A G+ +V+D ++
Sbjct: 404 LQNNASPNELTVNGNTALGIARRLGYISVVDTLK 437
Score = 173 bits (421), Expect = 6e-42
Identities = 134/468 (28%), Positives = 223/468 (47%), Gaps = 38/468 (8%)
Query: 750 LLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQ 809
LL A PN +G TP+H+A K + + LLL+ G T+ +G TP+
Sbjct: 7 LLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTE-------SGLTPIH 59
Query: 810 MACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADR 869
+A +IV L+ H G S +T + G +ALH A + +
Sbjct: 60 VAAFMGHVNIVSQLM-----HHGASPNTTNV-----RGETALHMAAR---------SGQA 100
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
+VV+ L+++GA V + + + +T H A G D++ +++ + N + G
Sbjct: 101 EVVRYLVQDGAQVEAKAK-DDQTPLHISARLGKADIVQQLLQQ------GASPNAATTSG 153
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
+TPL ++ GH + LL + A + + +G + LH+AA++G L+V + LL A +
Sbjct: 154 YTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPD 213
Query: 990 SKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL 1049
+ ++G T LH+AA + V L+ D A TPLH+AA Q+++ LL
Sbjct: 214 AAGKSGLTPLHVAA-HYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLL 272
Query: 1050 ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSV 1109
E GA+ +A G +H AAQ + ++V L L ++ N V + K G T H+AA + V
Sbjct: 273 EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNAN-VNLSNKSGLTPLHLAAQEDRV 331
Query: 1110 KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAV 1169
V E L+ ++ + A+ K+ TPL + G+ +V L++ A + + G T +
Sbjct: 332 NVAEVLV--NQGAHVDAQTKMG-YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPL 388
Query: 1170 HLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVREL 1217
H AA+ GHT++++V+ N G T L IA G V L
Sbjct: 389 HQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 436
Score = 163 bits (396), Expect = 6e-39
Identities = 123/416 (29%), Positives = 198/416 (47%), Gaps = 36/416 (8%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G IH AA GHV I++ L+ G S + T TALH+A S + VV L+ GA V
Sbjct: 54 GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQV 113
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ K +TPLHI+AR+ D LL+ GA PN AT G TP+H++A+ G+
Sbjct: 114 EAK-AKDDQTPLHISARLGKAD-IVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAF 171
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL+ G TK G TPL +A + ++ L++ +A DA
Sbjct: 172 LLDHGASLSITTK-------KGFTPLHVAAKYGKLEVANLLLQ----------KSASPDA 214
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
+ G + LH A ++V + L++ GA ++ + T H A
Sbjct: 215 AGKSGLTPLHVAAHYDNQKVAL---------LLLDQGASPHAAAKNGY-TPLHIAAKKNQ 264
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
D+ T ++ + + A+ A+ RQ G + +A GH+ +V+ LL +A V++ + G
Sbjct: 265 MDIATTLLEYGADAN---AVTRQ---GIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSG 318
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+ LHLAA+ + V + L+ A ++++ + G T LH+ G +V FL++ H+A +
Sbjct: 319 LTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQ-HSAKV 377
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVV 1078
+ T TPLH AA G + +LL+ A+ + G + A + Y VV
Sbjct: 378 NAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVV 433
Score = 160 bits (389), Expect = 4e-38
Identities = 133/470 (28%), Positives = 216/470 (45%), Gaps = 40/470 (8%)
Query: 682 LLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIP 741
LL K + + + +T LHIA + + V+E LL +GA + + TP+H+AA +
Sbjct: 7 LLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQ-AVTESGLTPIHVAAFMG 65
Query: 742 DGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDV 801
+ L+ GA PN G T +H+AA+ G + L++DG K K
Sbjct: 66 HVN-IVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAK------ 118
Query: 802 VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEE 861
+TPL ++ R DIV+ L++ +G S +A G + LH + + E+
Sbjct: 119 -DDQTPLHISARLGKADIVQQLLQ-----QGASP-----NAATTSGYTPLHLSAREGHED 167
Query: 862 VKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRA 921
V L+++GA +S+ T+ T H A G +V ++ ++ D +
Sbjct: 168 ---------VAAFLLDHGASLSITTKKGF-TPLHVAAKYGKLEVANLLLQKSASPDAA-- 215
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
G TPL +A H + ++ LL A G + LH+AA+ + + L
Sbjct: 216 ----GKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL 271
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
L A N+ R G ++HLAA G+ +V L+ NA +++ TPLHLAA +
Sbjct: 272 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL-GRNANVNLSNKSGLTPLHLAAQEDR 330
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAH 1101
+ V ++L+ GA++DA ++G P+H ++V FL QH V A TK+G T H
Sbjct: 331 VNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVN-FLLQHSAKVNAKTKNGYTPLH 389
Query: 1102 IAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
AA QG +I L+ + +N +T L +A G+ VV L
Sbjct: 390 QAAQQGHTHIINVLL---QNNASPNELTVNGNTALGIARRLGYISVVDTL 436
Score = 159 bits (385), Expect = 1e-37
Identities = 128/458 (27%), Positives = 211/458 (46%), Gaps = 39/458 (8%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K +G +H A + + ++ LL+ G S+ T T +H+A +V L+ +
Sbjct: 17 KALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHH 76
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
GA + + ET LH+AAR + L++ GA +D TP+H++A+ G
Sbjct: 77 GASPNTT-NVRGETALHMAARSGQAE-VVRYLVQDGAQVEAKAKDDQTPLHISARLGKAD 134
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LL+ G P T +G TPL ++ R D+ F+ DH G S+S
Sbjct: 135 IVQQLLQQGASPNAAT-------TSGYTPLHLSAREGHEDVA----AFLLDH-GASLS-- 180
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVS-LQTRHNHETAFHYC 897
+ G + LH A K K EV A+ + K + A S L H A HY
Sbjct: 181 ---ITTKKGFTPLHVAAKYGKLEV----ANLLLQKSASPDAAGKSGLTPLH---VAAHY- 229
Query: 898 AIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
+N + ++ + + A N G+TPL IA + M + TLL A +
Sbjct: 230 ----DNQKVALLLLDQGASPHAAAKN-----GYTPLHIAAKKNQMDIATTLLEYGADANA 280
Query: 958 FDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRD 1017
+G +++HLAA+ G++ + LL A +N ++G T LHLAA ++ + L+ +
Sbjct: 281 VTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLV-N 339
Query: 1018 HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEV 1077
A +D T TPLH+ G I++ LL+ A ++A + G P+H AAQ ++ +
Sbjct: 340 QGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHI 399
Query: 1078 VQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEEL 1115
+ + LQ + + T +GNT IA G + V++ L
Sbjct: 400 INVLLQNNAS-PNELTVNGNTALGIARRLGYISVVDTL 436
Score = 157 bits (382), Expect = 3e-37
Identities = 113/357 (31%), Positives = 181/357 (50%), Gaps = 22/357 (6%)
Query: 1091 ATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRV 1150
A +G T HIA + +KV+E L+K + I A + + TP+ +AA GH ++V
Sbjct: 16 AKALNGFTPLHIACKKNRIKVMELLLKHGAS--IQAVTE-SGLTPIHVAAFMGHVNIVSQ 72
Query: 1151 LVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQ 1210
L+ GAS N G TA+H+AA G V+ + + K TPLHI+A G+
Sbjct: 73 LMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGK 132
Query: 1211 AETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQ 1270
A+ V++LL G S P SG TPLHL+A G+E+V LL+
Sbjct: 133 ADIVQQLLQQ-----------GAS--PNAATTSGYTPLHLSAREGHEDVAAFLLDHGA-- 177
Query: 1271 ADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVE 1330
+ + + + G+ PLH+A G + + LLL +SA + + G T LH+A+ + + ++
Sbjct: 178 SLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP-DAAGKSGLTPLHVAAHYDNQKVAL 236
Query: 1331 VLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASEN 1390
+LL QGA +A KNG+TPLH AAK +++ L E GA + T A + AA E
Sbjct: 237 LLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEG 296
Query: 1391 HNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKL 1447
H D++ LL + + + +K + L + ++ + + + E ++ A VD K+
Sbjct: 297 HVDMVSLLLGRNANVN--LSNKSGLTPLHLAAQ-EDRVNVAEVLVNQGAHVDAQTKM 350
Score = 117 bits (282), Expect = 4e-25
Identities = 71/211 (33%), Positives = 112/211 (53%), Gaps = 8/211 (3%)
Query: 1237 PVLGAESGLTPLHLAAYNGNENVVRLLL-NSAGVQADAASNENGYNPLHLACFGGHMSIV 1295
P A +G TPLH+A V+ LLL + A +QA E+G P+H+A F GH++IV
Sbjct: 14 PNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA---VTESGLTPIHVAAFMGHVNIV 70
Query: 1296 GLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAK 1355
L+ A ++T+ G+T LH+A+ G ++V L+ GA++ A K+ TPLH +A+
Sbjct: 71 SQLMHHGASP-NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISAR 129
Query: 1356 AGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFV 1415
G ++V+ L + GASP + T P+ +A E H DV +LL +H + K+
Sbjct: 130 LGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLL--DHGASLSITTKKGF 187
Query: 1416 YNLMVCSKNHNNIPIEEFVLVSPAPVDTAAK 1446
L V +K + + + +L A D A K
Sbjct: 188 TPLHVAAK-YGKLEVANLLLQKSASPDAAGK 217
Score = 87.0 bits (206), Expect = 6e-16
Identities = 55/162 (33%), Positives = 83/162 (51%), Gaps = 3/162 (1%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V + G P+ +A G+ ++V +L+ + T G+TALH+AAR ++ R LV
Sbjct: 50 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPN--TTNVRGETALHMAARSGQAEVVRYLV 107
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
GA V+A QTPLHI+A G +V+ A+ A TP+HL+A GH
Sbjct: 108 QDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHED 167
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+ L D AS+ TK G T +H+A+ G + A +L +K
Sbjct: 168 VAAFLLD-HGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK 208
Score = 85.8 bits (203), Expect = 1e-15
Identities = 56/167 (33%), Positives = 86/167 (51%), Gaps = 3/167 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL +A + N+ V ELL A ++A T +G T +H+AA V++ L+ +GA
Sbjct: 21 GFTPLHIACKK-NRIKVMELLLKHGAS-IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGA 78
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ TN G+T LH+AA G +V+Y A +D+TP+H++A G A I++
Sbjct: 79 SPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQ 138
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L + AS T G T +H+++ GH D A L G L + K
Sbjct: 139 LLQQ-GASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTK 184
Score = 81.8 bits (193), Expect = 2e-14
Identities = 53/158 (33%), Positives = 77/158 (48%), Gaps = 3/158 (1%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL ++ G +V++LL Q A T +G T LHL+AR D+A L+D+GA
Sbjct: 121 QTPLHISARLGKADIVQQLL--QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGAS 178
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
+ T G TPLH+AA G + A+ A TP+H+AA + + LL
Sbjct: 179 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 238
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
D+ AS K+G T +HIA+ D A L + G
Sbjct: 239 LDQ-GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYG 275
Score = 81.0 bits (191), Expect = 4e-14
Identities = 50/173 (28%), Positives = 82/173 (47%), Gaps = 3/173 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D + G PL +A NQ + LL + A G T LH+AA++ +D+A
Sbjct: 213 DAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKN--GYTPLHIAAKKNQMDIATT 270
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L++YGA +A G +H+AA EG +V G AN +++ TP+HLAA+
Sbjct: 271 LLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDR 330
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+ E+L ++ A + +TK G T +H+ G+ L + ++ K
Sbjct: 331 VNVAEVLVNQ-GAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTK 382
Score = 78.6 bits (185), Expect = 2e-13
Identities = 53/152 (34%), Positives = 76/152 (50%), Gaps = 3/152 (1%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++G + LA + G+ MV LL L + +G T LHLAA+ V++A +LV
Sbjct: 281 VTRQGIASVHLAAQEGHVDMVSLLLGRNANVNL--SNKSGLTPLHLAAQEDRVNVAEVLV 338
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
+ GA VDA G TPLH+ G+ +V + A TP+H AA+ GH
Sbjct: 339 NQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTH 398
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGH 210
II +L AS E T +G+T + IA G+
Sbjct: 399 IINVLLQN-NASPNELTVNGNTALGIARRLGY 429
Score = 72.1 bits (169), Expect = 2e-11
Identities = 49/169 (28%), Positives = 80/169 (47%), Gaps = 3/169 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL +A + G + LL Q + A +G T LH+AA + +A +L+D
Sbjct: 184 KKGFTPLHVAAKYGKLEVANLLL--QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 241
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA A G TPLHIAA + + A+A + +HLAA+ GH ++
Sbjct: 242 GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMV 301
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
LL + A++ K G T +H+A+ + A +L +G ++ K
Sbjct: 302 SLLLGR-NANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTK 349
Score = 71.3 bits (167), Expect = 3e-11
Identities = 45/159 (28%), Positives = 74/159 (46%), Gaps = 3/159 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A + + LL + A T G ++HLAA+ VDM +L+
Sbjct: 250 KNGYTPLHIAAKKNQMDIATTLL--EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGR 307
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A V+ +N +G TPLH+AA E + + A+ TP+H+ G+ I+
Sbjct: 308 NANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIV 367
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
L + A + +TK+G T +H A+ GH +L +
Sbjct: 368 NFLL-QHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 405
Score = 46.4 bits (105), Expect = 0.001
Identities = 33/121 (27%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL LA + + V E+L Q A + A T G T LH+ ++ + L+ + A
Sbjct: 318 GLTPLHLAAQEDRVN-VAEVLVNQGAH-VDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSA 375
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+A G TPLH AA +G ++ A+ T + +A G+ ++++
Sbjct: 376 KVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDT 435
Query: 183 L 183
L
Sbjct: 436 L 436
Score = 41.5 bits (93), Expect = 0.031
Identities = 32/113 (28%), Positives = 49/113 (43%), Gaps = 1/113 (0%)
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+D A +A G TPLHIA + +++ A+ TP+H+AA GH
Sbjct: 7 LLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGH 66
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
I+ L AS G T +H+A+ +G A+ L + G + K
Sbjct: 67 VNIVSQLM-HHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAK 118
>AK097086-1|BAC04946.1| 919|Homo sapiens protein ( Homo sapiens cDNA
FLJ39767 fis, clone SPLEN2000607, weakly similar to
ANKYRIN 1. ).
Length = 919
Score = 218 bits (533), Expect = 2e-55
Identities = 218/767 (28%), Positives = 338/767 (44%), Gaps = 89/767 (11%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA G II L+ G V+ N T LH AV S V+ L+ + ADV+ R
Sbjct: 20 LHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNAR- 78
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
K +TPLH+AA KCA +++ + N + G T +H AA G++ + LLL
Sbjct: 79 DKNWQTPLHVAA-ANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAK 137
Query: 787 GGDPL---RKTKVCIY--------DVVT---------------GETPLQMACRSCMPDIV 820
G + +K + ++ DVV G TPL A + ++V
Sbjct: 138 GANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVV 197
Query: 821 RHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGA 880
+HL+ + ID ++ G +ALH AC VV LI+ GA
Sbjct: 198 KHLLNLGVE----------IDEINVYGNTALHIACY---------NGQDAVVNELIDYGA 238
Query: 881 DVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRG 940
+V+ Q +N T H+ A + + + E++ + + ADV N Q+ G +PL + G
Sbjct: 239 NVN-QPNNNGFTPLHFAAASTHGALCLELLVN-NGADV----NIQSKDGKSPLHMTAVHG 292
Query: 941 HMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALH 1000
TL+ N +D D +G + LH+AA +G+ + + L T+ A + LH
Sbjct: 293 RFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLH 352
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDE 1060
LAA+N ++ + L+ ID +T LH AAA G +E KLL GA+ D+
Sbjct: 353 LAALNAHSDCCRKLL-SSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDK 411
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDR 1120
G+ P+H AA N + ++ + N V T G T H AA DR
Sbjct: 412 CGRTPLHYAAANCHFHCIETLVTTGAN-VNETDDWGRTALHYAAAS----------DMDR 460
Query: 1121 TGVISARNKLNDSTPLQLAAEGGHADV---VRVLVRAGASCTDENRAGLTAVHLAAEHGH 1177
I N ++S L+ A E + + L++ A+ + ++ G ++H AA +GH
Sbjct: 461 NKTILG-NAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGH 519
Query: 1178 TNVLDVM--RSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSL 1235
L+++ R+ + S +PLH+AAY G + + LL SL
Sbjct: 520 RQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQ--------------SL 565
Query: 1236 VPV-LGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSI 1294
V + + E G T L LAA+ G+ V L+N G N PLH + GH
Sbjct: 566 VDLDIRDEKGRTALDLAAFKGHTECVEALIN-PGASIFVKDNVTKRTPLHASVINGHTLC 624
Query: 1295 VGLLL--SRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHC 1352
+ LLL + + E + D G+T L +A +GH V +LL + A ++ D G T LH
Sbjct: 625 LRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHR 684
Query: 1353 AAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
GH V++L E S + + P+ +AA+ H L LL
Sbjct: 685 GIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELL 731
Score = 215 bits (526), Expect = 1e-54
Identities = 210/743 (28%), Positives = 335/743 (45%), Gaps = 65/743 (8%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA V ++ SV+V+ TALH A + +V LL GA+++
Sbjct: 86 LHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFD 145
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
K R LH AA + D AL L+ GA + G TP+H AA G + + LL
Sbjct: 146 KKDRRA-LHWAAYMGHLDVVAL-LINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNL 203
Query: 787 GGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDED 846
G + ++ +Y G T L +AC + +V LI++ A ++ + +
Sbjct: 204 G---VEIDEINVY----GNTALHIACYNGQDAVVNELIDY----------GANVNQPNNN 246
Query: 847 GASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVM 906
G + LH+A T + ++ L+ NGADV++Q++ ++ H A+ G
Sbjct: 247 GFTPLHFAAASTHGAL--------CLELLVNNGADVNIQSKDG-KSPLHMTAVHGRFTRS 297
Query: 907 TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSAL 966
+I + D + G TPL +A GH L+NTL T+ A + L
Sbjct: 298 QTLIQNGGEIDCV------DKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPL 351
Query: 967 HLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
HLAA + + C LL++ I++ + GRT LH AA G +K L++ A
Sbjct: 352 HLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIK-LLQSSGADFHKKD 410
Query: 1027 LKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP 1086
+TPLH AAA+ + L+ GAN++ TD+ G+ +H AA ++ + H
Sbjct: 411 KCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHD 470
Query: 1087 NLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHAD 1146
N +++ + + ++ +E L++ D I + N + AA GH
Sbjct: 471 N-----SEELERARELKEKEATL-CLEFLLQNDANPSIRDKEGYNS---IHYAAAYGHRQ 521
Query: 1147 VVRVLVRAGASCTDENRAGLTA--VHLAAEHGHTNVLDVM-RSTNTLRISSKKLGLTPLH 1203
+ +L+ S +E+ +G T +HLAA +GH L+V+ +S L I +K G T L
Sbjct: 522 CLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEK-GRTALD 580
Query: 1204 IAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLL 1263
+AA+ G E V L++ PG + + V + TPLH + NG+ +RLL
Sbjct: 581 LAAFKGHTECVEALIN--PG----------ASIFVKDNVTKRTPLHASVINGHTLCLRLL 628
Query: 1264 LNSA-GVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIAST 1322
L A +A + G PL LA GH+ V LLL + A + + D G T LH
Sbjct: 629 LEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANV-DTVDILGCTALHRGIM 687
Query: 1323 HGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKS---ETNLN 1379
GH + V++LL Q I D G TPLH AA GH + L + S + + N
Sbjct: 688 TGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQG 747
Query: 1380 CAPIWFAASENHNDVLEYLLHKE 1402
P+ +A + + +E LL ++
Sbjct: 748 YTPLHWACYNGNENCIEVLLEQK 770
Score = 213 bits (520), Expect = 6e-54
Identities = 196/666 (29%), Positives = 295/666 (44%), Gaps = 68/666 (10%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DG +H A +G TL+Q G +D D T LH+A ++ TL GAD
Sbjct: 280 DGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD 339
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ G PLH+AA D C LL SG + + G T +H AA GN+ +
Sbjct: 340 T-AKCGIHSMFPLHLAALNAHSD-CCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIK 397
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LL G D +K K C G TPL A +C + L+ + A ++
Sbjct: 398 LLQSSGADFHKKDK-C------GRTPLHYAAANCHFHCIETLV----------TTGANVN 440
Query: 842 AVDEDGASALHYACKVTKEEVKI----------------PTADRQVVKC---LIENGADV 882
D+ G +ALHYA + K +++ C L++N A+
Sbjct: 441 ETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANP 500
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
S++ + + + HY A G+ + E++ + + + + +PL +A + GH
Sbjct: 501 SIRDKEGY-NSIHYAAAYGHRQCL-ELLLERTNSGFEES---DSGATKSPLHLAAYNGHH 555
Query: 943 QLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKAR-NGRTALHL 1001
Q + LL + +D+ D +GR+AL LAA G+ + +AL+ A I K RT LH
Sbjct: 556 QALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHA 615
Query: 1002 AAMNGYAHLVKFL--IRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATD 1059
+ +NG+ ++ L I D+ +DV K QTPL LA A G I+ LLLE AN+D D
Sbjct: 616 SVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVD 675
Query: 1060 ELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFD 1119
LG +H + E VQ+ L+Q +++ ++ G T H AA +G + EL++
Sbjct: 676 ILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSR-GRTPLHYAAARGHATWLSELLQMA 734
Query: 1120 RTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAG-LTAVHLAAEHGHT 1178
+ TPL A G+ + + VL+ C + T +H A + H
Sbjct: 735 LSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE--QKCFRKFIGNPFTPLHCAIINDHG 792
Query: 1179 NVLDVMRSTNTLRISSKK--LGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLV 1236
N ++ I S + G TPL AA+ E ++ LL H AP V+ V
Sbjct: 793 NCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRH-------SAP--VNAV 843
Query: 1237 PVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYN-PLHLACFGGHMSIV 1295
SG T L +AA NG V +L+NSA QAD + N PLHLAC GH
Sbjct: 844 D----NSGKTALMMAAENGQAGAVDILVNSA--QADLTVKDKDLNTPLHLACSKGHEKCA 897
Query: 1296 GLLLSR 1301
L+L +
Sbjct: 898 LLILDK 903
Score = 210 bits (514), Expect = 3e-53
Identities = 207/765 (27%), Positives = 332/765 (43%), Gaps = 47/765 (6%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA G + ++ LL G +D TALHIA + + AVV L+ YGA+V
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + TPLH AA G C +L+ +GA N ++DG +P+H+ A G
Sbjct: 241 N-QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQT 299
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
L+++GG+ C+ G TPL +A R ++ L D + + F
Sbjct: 300 LIQNGGEI-----DCVDK--DGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLH 352
Query: 843 VDEDGASALHYAC--KVTKEEVKIPTADRQVVKCL--IENGADVS-LQTRHNHETAFHYC 897
+ A H C K+ +I T D+ CL G +V ++ + FH
Sbjct: 353 L---AALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKK 409
Query: 898 AIAGNNDV-MTEMIAH---ISTADVSRA-LNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
G + H I T + A +N + G T L A M T+L N
Sbjct: 410 DKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA-ASDMDRNKTILGN- 467
Query: 953 ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVK 1012
A + ++E A L + L + + LL N A + + + G ++H AA G+ ++
Sbjct: 468 AHDNSEELE--RARELKEKEATLCL-EFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLE 524
Query: 1013 FLI-RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQ 1071
L+ R ++ + + ++PLHLAA +G + ++LL+ ++D DE G+ + AA
Sbjct: 525 LLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAF 584
Query: 1072 NNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKF-DRTGVISARNKL 1130
++E V+ + ++ + T H + I G + L++ D + ++
Sbjct: 585 KGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDA- 643
Query: 1131 NDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTL 1190
TPL LA GH D V +L+ A+ + G TA+H GH + ++
Sbjct: 644 KGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVS 703
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHL 1250
+ G TPLH AA G A + ELL SE G TPLH
Sbjct: 704 ILCKDSRGRTPLHYAAARGHATWLSELLQ----MALSEEDC------CFKDNQGYTPLHW 753
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR-SAELLHST 1309
A YNGNEN + +LL + N + PLH A H + LLL + ++
Sbjct: 754 ACYNGNENCIEVLLEQKCFRKFIG---NPFTPLHCAIINDHGNCASLLLGAIDSSIVSCR 810
Query: 1310 DRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESG 1369
D G+T L A+ H + +++LL A +NA D +G T L AA+ G V +L S
Sbjct: 811 DDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870
Query: 1370 ASPKS--ETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDK 1412
+ + + +LN P+ A S+ H +L K D +SL+++K
Sbjct: 871 QADLTVKDKDLN-TPLHLACSKGHEKCALLILDKIQD-ESLINEK 913
Score = 198 bits (482), Expect = 2e-49
Identities = 176/699 (25%), Positives = 306/699 (43%), Gaps = 58/699 (8%)
Query: 729 QRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGG 788
++ TPLH+AA + D + L++L SGA N +TP+H A + + +L++
Sbjct: 15 EKRTPLHVAAFLGDAEIIELLIL-SGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSA 73
Query: 789 DPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGA 848
D + K +TPL +A + +I + ++ D G
Sbjct: 74 DVNARDK-------NWQTPLHVAAANKAVKCAEVIIPLLSS----------VNVSDRGGR 116
Query: 849 SALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTE 908
+ALH+A ++V L+ GA+++ + + A H+ A G+ DV+
Sbjct: 117 TALHHAAL---------NGHVEMVNLLLAKGANINAFDKKDRR-ALHWAAYMGHLDVVAL 166
Query: 909 MIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHL 968
+I H A+V+ ++ G+TPL A G + +V LL +D +V G +ALH+
Sbjct: 167 LINH--GAEVTC----KDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHI 220
Query: 969 AAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLK 1028
A +G V + L+ A +N NG T LH AA + + L L+ ++ A +++ +
Sbjct: 221 ACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKD 280
Query: 1029 KQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNL 1088
++PLH+ A G+ + L++ G ID D+ G P+H AA+ + ++ +
Sbjct: 281 GKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADT 340
Query: 1089 VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVV 1148
H+AA+ +L+ I +K T L AA GG+ + +
Sbjct: 341 AKCGI-HSMFPLHLAALNAHSDCCRKLLSSGFE--IDTPDKFG-RTCLHAAAAGGNVECI 396
Query: 1149 RVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA-- 1206
++L +GA +++ G T +H AA + H + ++ + +T + G T LH AA
Sbjct: 397 KLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAAS 456
Query: 1207 -------YYGQAETVRELLSHVPGTVKSEAPTGVSLV------PVLGAESGLTPLHLAAY 1253
G A E L + EA + + P + + G +H AA
Sbjct: 457 DMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAA 516
Query: 1254 NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHG 1313
G+ + LLL + + + +PLHLA + GH + +LL + L D G
Sbjct: 517 YGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVD-LDIRDEKG 575
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDK-NGWTPLHCAAKAGHLNVVKLLCESGASP 1372
+T L +A+ GH + VE L+ GA I D TPLH + GH ++LL E +P
Sbjct: 576 RTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNP 635
Query: 1373 KS---ETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
++ + P+ A + H D + LL KE + ++
Sbjct: 636 EAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTV 674
Score = 186 bits (452), Expect = 1e-45
Identities = 194/715 (27%), Positives = 317/715 (44%), Gaps = 62/715 (8%)
Query: 749 MLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPL 808
ML+ N + TP+HVAA G+ + LL+ G K + + TPL
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWL-------TPL 53
Query: 809 QMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTAD 868
A S + V+ LI+ D ++A D++ + LH A A
Sbjct: 54 HRAVASRSEEAVQVLIKHSAD----------VNARDKNWQTPLHVA------------AA 91
Query: 869 RQVVKC---LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQ 925
+ VKC +I + V++ R TA H+ A+ G+ +++ ++A + + +R+
Sbjct: 92 NKAVKCAEVIIPLLSSVNVSDR-GGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRR 150
Query: 926 NSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNK 985
++ W A + GH+ +V L+ + A V D +G + LH AA +G + V LL
Sbjct: 151 -ALHW-----AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLG 204
Query: 986 AFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVC 1045
I+ G TALH+A NG +V LI D+ A ++ TPLH AAAS +C
Sbjct: 205 VEIDEINVYGNTALHIACYNGQDAVVNELI-DYGANVNQPNNNGFTPLHFAAASTHGALC 263
Query: 1046 -KLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
+LL+ GA+++ + G+ P+H A + Q + Q+ + KDGNT H+AA
Sbjct: 264 LELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLI-QNGGEIDCVDKDGNTPLHVAA 322
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
G +I L +G +A+ ++ PL LAA H+D R L+ +G ++
Sbjct: 323 RYGHELLINTLR---TSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKF 379
Query: 1165 GLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGT 1224
G T +H AA G+ + +++S+ K G TPLH AA + L++
Sbjct: 380 GRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANV 439
Query: 1225 VKSE--APTGVSLVPVLGAESGLTPLHLAAYNGNE-NVVRLLLNSAG-------VQADA- 1273
+++ T + + T L A N E R L +Q DA
Sbjct: 440 NETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDAN 499
Query: 1274 --ASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHG-KTGLHIASTHGHYQMVE 1330
++ GYN +H A GH + LLL R+ +D K+ LH+A+ +GH+Q +E
Sbjct: 500 PSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALE 559
Query: 1331 VLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNL-NCAPIWFAASE 1389
VLL +++ D+ G T L AA GH V+ L GAS + N+ P+ +
Sbjct: 560 VLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVIN 619
Query: 1390 NHNDVLEYLLHKEHDTQSL-MDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDT 1443
H L LL + +++ + D + LM+ + + +I +L A VDT
Sbjct: 620 GHTLCLRLLLEIADNPEAVDVKDAKGQTPLML-AVAYGHIDAVSLLLEKEANVDT 673
Score = 173 bits (421), Expect = 6e-42
Identities = 205/756 (27%), Positives = 320/756 (42%), Gaps = 63/756 (8%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H AA GHV ++N LL KG +++ + ALH A VV L+ +GA+V
Sbjct: 115 GRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEV 174
Query: 723 HIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ K+ TPLH AA +G LL G ++ G T +H+A G A +
Sbjct: 175 TCK-DKKGYTPLHAAA--SNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVN 231
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
L++ G + + G TPL A S + L+ + G A ++
Sbjct: 232 ELIDYGANVNQPNN-------NGFTPLHFAAASTHGALCLELLV----NNG-----ADVN 275
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
+DG S LH +T + + + LI+NG ++ + + T H A G
Sbjct: 276 IQSKDGKSPLH----MTAVHGRFTRS-----QTLIQNGGEIDCVDKDGN-TPLHVAARYG 325
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ ++ + S AD ++ PL +A H LL++ +D D
Sbjct: 326 HELLINTL--RTSGADTAKC----GIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKF 379
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM 1021
GR+ LH AA G ++ L ++ A + K + GRT LH AA N + H ++ L+ A
Sbjct: 380 GRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTT-GAN 438
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
++ +T LH AAAS ++ K + LG D ++EL + + + ++
Sbjct: 439 VNETDDWGRTALHYAAAS-DMDRNKTI--LGNAHDNSEEL--ERARELKEKEATLCLEFL 493
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
LQ N K+G H AA G + +E L++ +G + + S PL LAA
Sbjct: 494 LQNDAN-PSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKS-PLHLAAY 551
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTN-TLRISSKKLGLT 1200
GH + VL+++ + G TA+ LAA GHT ++ + + ++ + T
Sbjct: 552 NGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRT 611
Query: 1201 PLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVV 1260
PLH + G +R LL E V V A+ G TPL LA G+ + V
Sbjct: 612 PLHASVINGHTLCLRLLL---------EIADNPEAVDVKDAK-GQTPLMLAVAYGHIDAV 661
Query: 1261 RLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIA 1320
LLL D + G LH GH V +LL + +L D G+T LH A
Sbjct: 662 SLLLEKE-ANVDTV-DILGCTALHRGIMTGHEECVQMLLEQEVSIL-CKDSRGRTPLHYA 718
Query: 1321 STHGHYQMVEVLLGQG---AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETN 1377
+ GH + LL + D G+TPLH A G+ N +++L E K N
Sbjct: 719 AARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGN 778
Query: 1378 LNCAPIWFAASENHNDVLEYLLHK-EHDTQSLMDDK 1412
P+ A +H + LL + S DDK
Sbjct: 779 -PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDK 813
Score = 70.1 bits (164), Expect = 8e-11
Identities = 49/168 (29%), Positives = 77/168 (45%), Gaps = 4/168 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL A + + ++ ELL A+ + + G + LH+ A ++ L+ G
Sbjct: 247 GFTPLHFAAASTHGALCLELLVNNGAD-VNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGG 305
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA-AIIE 181
+D + G TPLH+AA G E L+ A+ A P+HLAA N H+ +
Sbjct: 306 EIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRK 365
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
LL+ F+ I K G T +H A+ G+ +C +L G H +K
Sbjct: 366 LLSSGFE--IDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDK 411
Score = 69.7 bits (163), Expect = 1e-10
Identities = 48/165 (29%), Positives = 78/165 (47%), Gaps = 3/165 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL AV + ++ V+ L+ + + + A T LH+AA + V A +++ + V+
Sbjct: 52 PLHRAVASRSEEAVQVLI--KHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVN 109
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
++ G+T LH AA G +V AN D +DR +H AA GH ++ LL +
Sbjct: 110 VSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
A + + K G T +H A+ NG + L GV + N Y
Sbjct: 170 H-GAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVY 213
Score = 69.7 bits (163), Expect = 1e-10
Identities = 48/168 (28%), Positives = 81/168 (48%), Gaps = 4/168 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L A G+ MV LL+ + A ALH AA +D+ +L+++GA
Sbjct: 115 GRTALHHAALNGHVEMVNLLLAK--GANINAFDKKDRRALHWAAYMGHLDVVALLINHGA 172
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V + G TPLH AA+ G +VK+ + + T +H+A NG A++
Sbjct: 173 EVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNE 232
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGH-ADCAMMLFKKGVYLHMPNK 229
L D + A++ + +G T +H A+ + H A C +L G +++ +K
Sbjct: 233 LID-YGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSK 279
Score = 68.9 bits (161), Expect = 2e-10
Identities = 49/166 (29%), Positives = 79/166 (47%), Gaps = 3/166 (1%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL +A G+ ++ ELL A ++ A T LH A R + ++L+ + A
Sbjct: 17 RTPLHVAAFLGDAEII-ELLILSGA-RVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSAD 74
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
V+A + QTPLH+AAA + + ++ ++D RT +H AA NGH ++ LL
Sbjct: 75 VNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLL 134
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
K A+I K +H A+ GH D +L G + +K
Sbjct: 135 LAK-GANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
Score = 68.9 bits (161), Expect = 2e-10
Identities = 39/125 (31%), Positives = 65/125 (52%), Gaps = 2/125 (1%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G T LH AA +++ + L++ G +D N G T LHIA G + +V AN
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
Query: 158 AIADNEDRTPMHLAAENGHAAI-IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMM 216
+N TP+H AA + H A+ +ELL + A + ++KDG + +H+ +++G +
Sbjct: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNN-GADVNIQSKDGKSPLHMTAVHGRFTRSQT 299
Query: 217 LFKKG 221
L + G
Sbjct: 300 LIQNG 304
Score = 67.3 bits (157), Expect = 6e-10
Identities = 50/172 (29%), Positives = 76/172 (44%), Gaps = 10/172 (5%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMA-RILVDYG 121
G L +A G ++V EL+ + G T LH AA + +LV+ G
Sbjct: 214 GNTALHIACYNGQDAVVNELIDY--GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNG 271
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE 181
A V+ + G++PLH+ A G + D + TP+H+AA GH E
Sbjct: 272 ADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGH----E 327
Query: 182 LLADKFKASIFERTKDGSTLM---HIASLNGHADCAMMLFKKGVYLHMPNKY 230
LL + + S + K G M H+A+LN H+DC L G + P+K+
Sbjct: 328 LLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKF 379
Score = 64.9 bits (151), Expect = 3e-09
Identities = 43/161 (26%), Positives = 74/161 (45%), Gaps = 5/161 (3%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY- 120
+G PL A GN++ + LL + + T LH A + A +L+
Sbjct: 746 QGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNP---FTPLHCAIINDHGNCASLLLGAI 802
Query: 121 -GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
++V + G+TPL AA ++ A DN +T + +AAENG A
Sbjct: 803 DSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGA 862
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+++L + +A + + KD +T +H+A GH CA+++ K
Sbjct: 863 VDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDK 903
Score = 64.1 bits (149), Expect = 5e-09
Identities = 46/160 (28%), Positives = 70/160 (43%), Gaps = 1/160 (0%)
Query: 69 LAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATN 128
L V A N+++ + + + G TALH AA V+M +L+ GA ++A +
Sbjct: 86 LHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFD 145
Query: 129 GAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFK 188
+ LH AA G +V A D + TP+H AA NG +++ L +
Sbjct: 146 KKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLN-LG 204
Query: 189 ASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
I E G+T +HIA NG L G ++ PN
Sbjct: 205 VEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 244
Score = 62.5 bits (145), Expect = 2e-08
Identities = 50/169 (29%), Positives = 75/169 (44%), Gaps = 5/169 (2%)
Query: 55 IRDLVFQRGKVPLLLAVEAGNQSMVRELLS-AQTAEQLKATTPAGDTALHLAARRRDVDM 113
++D V +R PL +V G+ +R LL A E + G T L LA +D
Sbjct: 603 VKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDA 660
Query: 114 ARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAE 173
+L++ A VD + G T LH G E V+ + D+ RTP+H AA
Sbjct: 661 VSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAA 720
Query: 174 NGHAA-IIELLADKF-KASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
GHA + ELL + + G T +H A NG+ +C +L ++
Sbjct: 721 RGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ 769
Score = 62.1 bits (144), Expect = 2e-08
Identities = 48/163 (29%), Positives = 74/163 (45%), Gaps = 7/163 (4%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
K PL LA G+ + LL Q+ L G TAL LAA + + L++ GA
Sbjct: 543 KSPLHLAAYNGHHQALEVLL--QSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGAS 600
Query: 124 VDAT-NGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED---RTPMHLAAENGHAAI 179
+ N +TPLH + G ++ + N D +D +TP+ LA GH
Sbjct: 601 IFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDA 660
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGV 222
+ LL +K +A++ G T +H + GH +C ML ++ V
Sbjct: 661 VSLLLEK-EANVDTVDILGCTALHRGIMTGHEECVQMLLEQEV 702
Score = 61.3 bits (142), Expect = 4e-08
Identities = 48/150 (32%), Positives = 70/150 (46%), Gaps = 3/150 (2%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D V + G PL +A G++ ++ L ++ A+ K + LHLAA D R
Sbjct: 308 DCVDKDGNTPLHVAARYGHELLINTLRTSG-ADTAKCGIHSM-FPLHLAALNAHSDCCRK 365
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+ G +D + G+T LH AAA G+ +K A+ D RTP+H AA N H
Sbjct: 366 LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCH 425
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIAS 206
IE L A++ E G T +H A+
Sbjct: 426 FHCIETLVTT-GANVNETDDWGRTALHYAA 454
Score = 54.0 bits (124), Expect = 5e-06
Identities = 56/218 (25%), Positives = 95/218 (43%), Gaps = 11/218 (5%)
Query: 7 DVPRSANINFSSGVRSPPANQQKDLQRLELSFIELNKERAKQKEWKKLIRDLVFQRGKVP 66
D+ R+ I ++ S + ++L+ E + L E Q + IRD + G
Sbjct: 457 DMDRNKTILGNAHDNSEELERARELKEKEAT---LCLEFLLQNDANPSIRD---KEGYNS 510
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
+ A G++ + LL + ++ + A + LHLAA +L+ +D
Sbjct: 511 IHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDI 570
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADN-EDRTPMHLAAENGHAAIIELL-- 183
+ G+T L +AA +G V+ A+ + DN RTP+H + NGH + LL
Sbjct: 571 RDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLE 630
Query: 184 -ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
AD +A + K G T + +A GH D +L +K
Sbjct: 631 IADNPEAVDVKDAK-GQTPLMLAVAYGHIDAVSLLLEK 667
Score = 52.8 bits (121), Expect = 1e-05
Identities = 35/124 (28%), Positives = 57/124 (45%), Gaps = 1/124 (0%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL A+ + + LL A + + G T L AA V+ ++L+ + A V+
Sbjct: 782 PLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVN 841
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYG-VRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A + +G+T L +AA G V +A+ + D + TP+HLA GH L+
Sbjct: 842 AVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
Query: 185 DKFK 188
DK +
Sbjct: 902 DKIQ 905
Score = 51.6 bits (118), Expect = 3e-05
Identities = 43/159 (27%), Positives = 61/159 (38%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
GK PL + G + + L+ Q ++ G+T LH+AAR + L GA
Sbjct: 281 GKSPLHMTAVHGRFTRSQTLI--QNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGA 338
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
PLH+AA + D RT +H AA G+ I+L
Sbjct: 339 DTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKL 398
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L A ++ K G T +H A+ N H C L G
Sbjct: 399 LQSS-GADFHKKDKCGRTPLHYAAANCHFHCIETLVTTG 436
Score = 48.4 bits (110), Expect = 3e-04
Identities = 30/96 (31%), Positives = 49/96 (51%), Gaps = 5/96 (5%)
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPMHLAAENGHAAIIE 181
V+ + +TPLH+AA GD +++ G R NA DN TP+H A + ++
Sbjct: 9 VNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNA--KDNMWLTPLHRAVASRSEEAVQ 66
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+L K A + R K+ T +H+A+ N CA ++
Sbjct: 67 VLI-KHSADVNARDKNWQTPLHVAAANKAVKCAEVI 101
Score = 46.8 bits (106), Expect = 8e-04
Identities = 37/129 (28%), Positives = 58/129 (44%), Gaps = 3/129 (2%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K G + A YGH+ ++ LL+K +VD TALH + + V+ LL
Sbjct: 641 KDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQ 700
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGN 776
+ + + R TPLH AA + +L + + + +D G TP+H A GN
Sbjct: 701 EVSILCKDSRGR-TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGN 759
Query: 777 LATLVLLLE 785
+ +LLE
Sbjct: 760 ENCIEVLLE 768
Score = 46.4 bits (105), Expect = 0.001
Identities = 48/158 (30%), Positives = 65/158 (41%), Gaps = 8/158 (5%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L A GN ++ LL + A+ K G T LH AA LV GA
Sbjct: 380 GRTCLHAAAAGGNVECIK-LLQSSGADFHKKDK-CGRTPLHYAAANCHFHCIETLVTTGA 437
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+ T+ G+T LH AAA D K G NA E L + + L
Sbjct: 438 NVNETDDWGRTALHYAAA-SDMDRNKTILG---NAHDNSEELERARELKEKEATLCLEFL 493
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L + SI R K+G +H A+ GH C +L ++
Sbjct: 494 LQNDANPSI--RDKEGYNSIHYAAAYGHRQCLELLLER 529
Score = 45.6 bits (103), Expect = 0.002
Identities = 44/165 (26%), Positives = 75/165 (45%), Gaps = 12/165 (7%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ PL A + + L++ T + T G TALH AA D+D + ++
Sbjct: 413 GRTPLHYAAANCHFHCIETLVT--TGANVNETDDWGRTALHYAAAS-DMDRNKTILG--- 466
Query: 123 VVDATNGAGQTPLHIAAAEGDEPL-VKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE 181
+A + + + E + L +++ AN +I D E +H AA GH +E
Sbjct: 467 --NAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLE 524
Query: 182 LLADKFKASIFERTKDGSTL--MHIASLNGHADCAMMLFKKGVYL 224
LL ++ + FE + G+T +H+A+ NGH +L + V L
Sbjct: 525 LLLERTNSG-FEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDL 568
>BC114476-1|AAI14477.1| 785|Homo sapiens ANKRD28 protein protein.
Length = 785
Score = 217 bits (531), Expect = 3e-55
Identities = 218/752 (28%), Positives = 331/752 (44%), Gaps = 76/752 (10%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA G II L+ G V+ + T LH AV SC V+ LL + ADV+ R
Sbjct: 78 LHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARD 137
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
K +TPLHIAA KCA L+ + N + G T +H AA G+ + LLL
Sbjct: 138 -KNWQTPLHIAAA-NKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSR 195
Query: 787 GGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDED 846
G + + +D + A ++V+ L+ H E + D+
Sbjct: 196 GAN------INAFDK-KDRRAIHWAAYMGHIEVVKLLVS----HGAE------VTCKDKK 238
Query: 847 GASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVM 906
+ LH A + VVK L++ G D++ + + T H G + V+
Sbjct: 239 SYTPLHAAAS---------SGMISVVKYLLDLGVDMNEPNAYGN-TPLHVACYNGQDVVV 288
Query: 907 TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLT-NHARVDVFDVEGRSA 965
E+I D +N++N G+TPL A H L LL N A V++ +G++
Sbjct: 289 NELI------DCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTP 342
Query: 966 LHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVL 1025
LH+ A HG ++ + A I+ + +NG T LH+AA G+ L+ LI A
Sbjct: 343 LHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITS-GADTAKR 401
Query: 1026 TLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQH 1085
+ PLHLAA SG + C+ LL G +ID D+ G+ +HAAA E + L L
Sbjct: 402 GIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTG 461
Query: 1086 PNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDS--TPLQLAAEGG 1143
+ K G + H AA + + + F G ++ N L++ TPL AA
Sbjct: 462 ADF-NKKDKFGRSPLHYAAANCNYQCL-----FALVGSGASVNDLDERGCTPLHYAATSD 515
Query: 1144 -HADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRS------------TNTL 1190
+ L+R A+ ++ G AVH +A +GH L ++ S T+ L
Sbjct: 516 TDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDML 575
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPV-LGAESGLTPLH 1249
S + ++PLH+AAY+G + + L+ SL+ + + SG TPL
Sbjct: 576 SDSDNRATISPLHLAAYHGHHQALEVLVQ--------------SLLDLDVRNSSGRTPLD 621
Query: 1250 LAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSA--ELLH 1307
LAA+ G+ V +L+N G P+H A GH + LL+ + +
Sbjct: 622 LAAFKGHVECVDVLINQ-GASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVD 680
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
D +G+T L ++ +GH V LL +GA ++A DK G T LH A GH V L +
Sbjct: 681 IQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQ 740
Query: 1368 SGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
GA + PI +A+ H VL LL
Sbjct: 741 HGAKCLLRDSRGRTPIHLSAACGHIGVLGALL 772
Score = 217 bits (530), Expect = 4e-55
Identities = 212/718 (29%), Positives = 328/718 (45%), Gaps = 64/718 (8%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H A + LL+ V+ + T LHIA + E L+ ++V++
Sbjct: 111 LHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSD 170
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
R T LH AA G+ L LL GA N + +H AA G++ + LL+
Sbjct: 171 RAGR-TALHHAAFSGHGEMVKL-LLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSH 228
Query: 787 GGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDED 846
G + K K TPL A S M +V++L++ D ++ +
Sbjct: 229 GAEVTCKDK-------KSYTPLHAAASSGMISVVKYLLDLGVD----------MNEPNAY 271
Query: 847 GASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVM 906
G + LH AC ++V VV LI+ GA V+ Q T H+ A + + +
Sbjct: 272 GNTPLHVAC-YNGQDV--------VVNELIDCGAIVN-QKNEKGFTPLHFAAASTHGALC 321
Query: 907 TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSAL 966
E++ + ADV N ++ G TPL + G T++ + A +D D G + L
Sbjct: 322 LELLVG-NGADV----NMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPL 376
Query: 967 HLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
H+AA +G+ + + L+T+ A + +G LHLAA++G++ + L+ ID
Sbjct: 377 HIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSS-GFDIDTPD 435
Query: 1027 LKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN-NYSEVVQLFLQQH 1085
+T LH AAA G +E LLL GA+ + D+ G+ P+H AA N NY + L
Sbjct: 436 DFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGA 495
Query: 1086 PNLVMATTKDGNTCAHIAAIQGSV-KVIEELMKFDRTGVISAR---NKLNDSTP------ 1135
V + G T H AA + K +E L++ D I + N ++ S
Sbjct: 496 S--VNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLC 553
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM-RSTNTLRISS 1194
LQL A DV+ +NRA ++ +HLAA HGH L+V+ +S L + +
Sbjct: 554 LQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRN 613
Query: 1195 KKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYN 1254
G TPL +AA+ G E V L++ G S++ V TP+H AA N
Sbjct: 614 SS-GRTPLDLAAFKGHVECVDVLINQ-----------GASIL-VKDYILKRTPIHAAATN 660
Query: 1255 GNENVVRLLLNSAGVQ-ADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHG 1313
G+ +RLL+ +A Q A + NG PL L+ GH V LL++ A + + D+ G
Sbjct: 661 GHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANV-DAKDKWG 719
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGAS 1371
+T LH + GH + V+ LL GA+ D G TP+H +A GH+ V+ L +S AS
Sbjct: 720 RTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAAS 777
Score = 198 bits (483), Expect = 2e-49
Identities = 193/685 (28%), Positives = 307/685 (44%), Gaps = 58/685 (8%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA V L+ +V+V+ TALH A S +V+ LL GA+++
Sbjct: 144 LHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFD 203
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
K R +H AA + + L L+ GA + TP+H AA G ++ + LL+
Sbjct: 204 KKDRRA-IHWAAYMGHIEVVKL-LVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDL 261
Query: 787 GGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDED 846
G D G TPL +AC + +V LI+ A ++ +E
Sbjct: 262 GVDMNEPN-------AYGNTPLHVACYNGQDVVVNELID----------CGAIVNQKNEK 304
Query: 847 GASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVM 906
G + LH+A T + ++ L+ NGADV+++++ + +T H A+ G
Sbjct: 305 GFTPLHFAAASTHGAL--------CLELLVGNGADVNMKSK-DGKTPLHMTALHGRFSRS 355
Query: 907 TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSAL 966
+I + D ++ G TPL IA GH L+NTL+T+ A + G L
Sbjct: 356 QTIIQSGAVIDC------EDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPL 409
Query: 967 HLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
HLAA G+ C LL++ I++ GRT LH AA G + L+ + A +
Sbjct: 410 HLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLL-NTGADFNKKD 468
Query: 1027 LKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP 1086
++PLH AAA+ + L+ GA+++ DE G P+H AA ++ +L ++
Sbjct: 469 KFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRND 528
Query: 1087 NLVMATTKDGNTCAHIAAIQG---------SVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
K G H +A G S ++ LM+ T ++S + +PL
Sbjct: 529 ANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLH 588
Query: 1138 LAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTN-TLRISSKK 1196
LAA GH + VLV++ N +G T + LAA GH +DV+ + ++ +
Sbjct: 589 LAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYI 648
Query: 1197 LGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGN 1256
L TP+H AA G +E +R L+ + +E V + +G TPL L+ NG+
Sbjct: 649 LKRTPIHAAATNGHSECLRLLIGN------AEPQNAVDIQD----GNGQTPLMLSVLNGH 698
Query: 1257 ENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTG 1316
+ V LLN G D A ++ G LH GH V LL A+ L D G+T
Sbjct: 699 TDCVYSLLNK-GANVD-AKDKWGRTALHRGAVTGHEECVDALLQHGAKCL-LRDSRGRTP 755
Query: 1317 LHIASTHGHYQMVEVLLGQGAEINA 1341
+H+++ GH ++ LL A ++A
Sbjct: 756 IHLSAACGHIGVLGALLQSAASMDA 780
Score = 180 bits (439), Expect = 4e-44
Identities = 184/735 (25%), Positives = 325/735 (44%), Gaps = 58/735 (7%)
Query: 679 INTLLQKGESVDVTTNDN----YTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPL 734
I+ L Q+ +S+ + N Y +L A+ + P V L+ DV+ + ++R TPL
Sbjct: 20 ISKLPQENKSLHSPPSGNVLVRYPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKR-TPL 78
Query: 735 HIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKT 794
H AA + D + L++L SGA N +TP+H A + + +LL+ D +
Sbjct: 79 HAAAYLGDAEIIELLIL-SGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARD 137
Query: 795 KVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYA 854
K +TPL +A + L+ + + ++ D G +ALH+A
Sbjct: 138 K-------NWQTPLHIAAANKAVKCAEALVPLLSN----------VNVSDRAGRTALHHA 180
Query: 855 CKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHIS 914
+ ++VK L+ GA+++ + + A H+ A G+ +V+ +++H
Sbjct: 181 AF---------SGHGEMVKLLLSRGANINAFDKKDRR-AIHWAAYMGHIEVVKLLVSH-- 228
Query: 915 TADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGY 974
A+V+ ++ +TPL A G + +V LL ++ + G + LH+A +G
Sbjct: 229 GAEVTC----KDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQ 284
Query: 975 LQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH 1034
V + L+ A +N K G T LH AA + + L L+ + A +++ + +TPLH
Sbjct: 285 DVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLH 344
Query: 1035 LAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTK 1094
+ A G+ + +++ GA ID D+ G P+H AA+ + ++ + +
Sbjct: 345 MTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGI- 403
Query: 1095 DGNTCAHIAAIQGSVKVIEELMK--FDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
G H+AA+ G +L+ FD I + T L AA GG+ + + +L+
Sbjct: 404 HGMFPLHLAALSGFSDCCRKLLSSGFD----IDTPDDFG-RTCLHAAAAGGNLECLNLLL 458
Query: 1153 RAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAE 1212
GA +++ G + +H AA + + L + + + G TPLH AA
Sbjct: 459 NTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDG 518
Query: 1213 TVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGV-QA 1271
E L G + V A L L A +E + +L+ ++G
Sbjct: 519 KCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIA---SETPLDVLMETSGTDML 575
Query: 1272 DAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEV 1331
+ N +PLHLA + GH + +L+ + L + G+T L +A+ GH + V+V
Sbjct: 576 SDSDNRATISPLHLAAYHGHHQALEVLVQSLLD-LDVRNSSGRTPLDLAAFKGHVECVDV 634
Query: 1332 LLGQGAEINATDK-NGWTPLHCAAKAGHLNVVKLLCESGASPKSETNL----NCAPIWFA 1386
L+ QGA I D TP+H AA GH ++LL A P++ ++ P+ +
Sbjct: 635 LINQGASILVKDYILKRTPIHAAATNGHSECLRLLI-GNAEPQNAVDIQDGNGQTPLMLS 693
Query: 1387 ASENHNDVLEYLLHK 1401
H D + LL+K
Sbjct: 694 VLNGHTDCVYSLLNK 708
Score = 172 bits (419), Expect = 1e-41
Identities = 123/377 (32%), Positives = 175/377 (46%), Gaps = 19/377 (5%)
Query: 1028 KKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPN 1087
+K+TPLH AA G E+ +LL+ GA ++A D P+H A + E VQ+ L+ H
Sbjct: 73 EKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLK-HSA 131
Query: 1088 LVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADV 1147
V A K+ T HIAA +VK E L+ +S R T L AA GH ++
Sbjct: 132 DVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRA---GRTALHHAAFSGHGEM 188
Query: 1148 VRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAY 1207
V++L+ GA+ ++ A+H AA GH V+ ++ S K TPLH AA
Sbjct: 189 VKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAAS 248
Query: 1208 YGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSA 1267
G V+ LL V P G TPLH+A YNG + VV L++
Sbjct: 249 SGMISVVKYLLDL---GVDMNEPNAY----------GNTPLHVACYNGQDVVVNELIDCG 295
Query: 1268 GVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQ 1327
+ NE G+ PLH A H ++ LL + ++ + GKT LH+ + HG +
Sbjct: 296 AIVNQ--KNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFS 353
Query: 1328 MVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAA 1387
+ ++ GA I+ DKNG TPLH AA+ GH ++ L SGA P+ AA
Sbjct: 354 RSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAA 413
Query: 1388 SENHNDVLEYLLHKEHD 1404
+D LL D
Sbjct: 414 LSGFSDCCRKLLSSGFD 430
Score = 163 bits (397), Expect = 5e-39
Identities = 126/425 (29%), Positives = 200/425 (47%), Gaps = 20/425 (4%)
Query: 980 ALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAAS 1039
AL+ K +N + RT LH AA G A +++ LI A ++ K TPLH A AS
Sbjct: 59 ALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILS-GARVNAKDSKWLTPLHRAVAS 117
Query: 1040 GQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTC 1099
E ++LL+ A+++A D+ Q P+H AA N + + + N V + + G T
Sbjct: 118 CSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSN-VNVSDRAGRTA 176
Query: 1100 AHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
H AA G ++++ L+ R I+A +K D + AA GH +VV++LV GA T
Sbjct: 177 LHHAAFSGHGEMVKLLLS--RGANINAFDK-KDRRAIHWAAYMGHIEVVKLLVSHGAEVT 233
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
+++ T +H AA G +V+ + G TPLH+A Y GQ V EL+
Sbjct: 234 CKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELID 293
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G + ++ E G TPLH AA + + + LL G + S + G
Sbjct: 294 C--GAIVNQKN-----------EKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD-G 339
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
PLH+ G S ++ +S ++ D++G T LHIA+ +GH ++ L+ GA+
Sbjct: 340 KTPLHMTALHGRFSRSQTII-QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADT 398
Query: 1340 NATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+G PLH AA +G + + L SG + + + AA+ + + L LL
Sbjct: 399 AKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLL 458
Query: 1400 HKEHD 1404
+ D
Sbjct: 459 NTGAD 463
Score = 163 bits (395), Expect = 8e-39
Identities = 136/468 (29%), Positives = 213/468 (45%), Gaps = 38/468 (8%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K DG +H A +G T++Q G +D + T LHIA ++ TL+
Sbjct: 335 KSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITS 394
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
GAD R G PLH+AA D C LL SG + + G T +H AA GNL
Sbjct: 395 GADTAKR-GIHGMFPLHLAALSGFSD-CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLE 452
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
L LLL G D +K K G +PL A +C + L+ S A
Sbjct: 453 CLNLLLNTGADFNKKDKF-------GRSPLHYAAANCNYQCLFALVG----------SGA 495
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
++ +DE G + LHYA T + D + ++ L+ N A+ ++ + + A HY A
Sbjct: 496 SVNDLDERGCTPLHYA--ATSD------TDGKCLEYLLRNDANPGIRDKQGY-NAVHYSA 546
Query: 899 IAGNNDVM------TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
G+ + T + + T+ + N +PL +A + GH Q + L+ +
Sbjct: 547 AYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSL 606
Query: 953 ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKAR-NGRTALHLAAMNGYAHLV 1011
+DV + GR+ L LAA G+++ D L+ A I K RT +H AA NG++ +
Sbjct: 607 LDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECL 666
Query: 1012 KFLI--RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA 1069
+ LI + +D+ QTPL L+ +G + LL GAN+DA D+ G+ +H
Sbjct: 667 RLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRG 726
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMK 1117
A + E V LQ ++ ++ G T H++A G + V+ L++
Sbjct: 727 AVTGHEECVDALLQHGAKCLLRDSR-GRTPIHLSAACGHIGVLGALLQ 773
Score = 153 bits (372), Expect = 5e-36
Identities = 170/620 (27%), Positives = 279/620 (45%), Gaps = 69/620 (11%)
Query: 665 RSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHI 724
R+IH AA GH+ ++ L+ G V +YT LH A S +VV+ LL G D++
Sbjct: 208 RAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN- 266
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA-TLVLL 783
TPLH+A D L+ GA N+ E G TP+H AA + A L LL
Sbjct: 267 EPNAYGNTPLHVAC-YNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELL 325
Query: 784 LEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAV 843
+ +G D K+K G+TPL M + +I+ S A ID
Sbjct: 326 VGNGADVNMKSK-------DGKTPLHMTALHGRFSRSQTIIQ----------SGAVIDCE 368
Query: 844 DEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN 903
D++G + LH A + E ++ LI +GAD + + H H A++G +
Sbjct: 369 DKNGNTPLHIAARYGHE---------LLINTLITSGADTAKRGIHG-MFPLHLAALSGFS 418
Query: 904 DVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGR 963
D ++++ S D+ + + G T L A G+++ +N LL A + D GR
Sbjct: 419 DCCRKLLS--SGFDI----DTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGR 472
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY-AHLVKFLIRDHNAMI 1022
S LH AA + Q AL+ + A +N G T LH AA + +++L+R ++A
Sbjct: 473 SPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLR-NDANP 531
Query: 1023 DVLTLKKQTPLHLAAASG-----QIEVCKLLLELGANIDATDELGQ-------KPIHAAA 1070
+ + +H +AA G Q+ + L++ TD L P+H AA
Sbjct: 532 GIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAA 591
Query: 1071 QNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKL 1130
+ + + +++ +Q +L + + G T +AA +G V+ ++ L+ ++ I ++ +
Sbjct: 592 YHGHHQALEVLVQSLLDLDVRNS-SGRTPLDLAAFKGHVECVDVLI--NQGASILVKDYI 648
Query: 1131 NDSTPLQLAAEGGHADVVRVLV--RAGASCTD-ENRAGLTAVHLAAEHGHTNVLDVMRST 1187
TP+ AA GH++ +R+L+ + D ++ G T + L+ +GHT+ + + +
Sbjct: 649 LKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNK 708
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+ K G T LH A G E V LL H G +L G TP
Sbjct: 709 GANVDAKDKWGRTALHRGAVTGHEECVDALLQH-----------GAKC--LLRDSRGRTP 755
Query: 1248 LHLAAYNGNENVVRLLLNSA 1267
+HL+A G+ V+ LL SA
Sbjct: 756 IHLSAACGHIGVLGALLQSA 775
Score = 132 bits (318), Expect = 2e-29
Identities = 110/372 (29%), Positives = 174/372 (46%), Gaps = 23/372 (6%)
Query: 1036 AAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKD 1095
A +G + + L+ +++ D + P+HAAA +E+++L + V A
Sbjct: 48 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGAR-VNAKDSK 106
Query: 1096 GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAG 1155
T H A S + ++ L+K + ++AR+K N TPL +AA LV
Sbjct: 107 WLTPLHRAVASCSEEAVQVLLK--HSADVNARDK-NWQTPLHIAAANKAVKCAEALVPLL 163
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
++ +RAG TA+H AA GH ++ ++ S + K +H AAY G E V+
Sbjct: 164 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 223
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS 1275
L+SH + + TPLH AA +G +VV+ LL+ GV +
Sbjct: 224 LLVSHGAEVTCKD-------------KKSYTPLHAAASSGMISVVKYLLD-LGVDMNEP- 268
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIA--STHGHYQMVEVLL 1333
N G PLH+AC+ G +V L+ A +++ + G T LH A STHG +E+L+
Sbjct: 269 NAYGNTPLHVACYNGQDVVVNELIDCGA-IVNQKNEKGFTPLHFAAASTHGAL-CLELLV 326
Query: 1334 GQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHND 1393
G GA++N K+G TPLH A G + + + +SGA E P+ AA H
Sbjct: 327 GNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHEL 386
Query: 1394 VLEYLLHKEHDT 1405
++ L+ DT
Sbjct: 387 LINTLITSGADT 398
Score = 72.5 bits (170), Expect = 1e-11
Identities = 52/165 (31%), Positives = 79/165 (47%), Gaps = 3/165 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL AV + ++ V+ LL + + + A T LH+AA + V A LV + V+
Sbjct: 110 PLHRAVASCSEEAVQVLL--KHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVN 167
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
++ AG+T LH AA G +VK AN D +DR +H AA GH +++LL
Sbjct: 168 VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLV- 226
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
A + + K T +H A+ +G L GV ++ PN Y
Sbjct: 227 SHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAY 271
Score = 71.7 bits (168), Expect = 3e-11
Identities = 49/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L A +G+ MV+ LLS + A A+H AA +++ ++LV +GA
Sbjct: 173 GRTALHHAAFSGHGEMVKLLLSR--GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA 230
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V + TPLH AA+ G +VKY + + + TP+H+A NG ++
Sbjct: 231 EVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNE 290
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGH-ADCAMMLFKKGVYLHMPNK 229
L D A + ++ + G T +H A+ + H A C +L G ++M +K
Sbjct: 291 LID-CGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSK 337
Score = 70.1 bits (164), Expect = 8e-11
Identities = 49/171 (28%), Positives = 80/171 (46%), Gaps = 4/171 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL A + + ++ ELL A+ + + G T LH+ A ++ ++
Sbjct: 303 EKGFTPLHFAAASTHGALCLELLVGNGAD-VNMKSKDGKTPLHMTALHGRFSRSQTIIQS 361
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA-AI 179
GAV+D + G TPLHIAA G E L+ A+ A P+HLAA +G +
Sbjct: 362 GAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCC 421
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
+LL+ F I G T +H A+ G+ +C +L G + +K+
Sbjct: 422 RKLLSSGF--DIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKF 470
Score = 67.7 bits (158), Expect = 4e-10
Identities = 43/132 (32%), Positives = 63/132 (47%), Gaps = 3/132 (2%)
Query: 102 LHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIAD 161
LHLAA +LV +D N +G+TPL +AA +G V A+ + D
Sbjct: 587 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 646
Query: 162 NE-DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGS--TLMHIASLNGHADCAMMLF 218
RTP+H AA NGH+ + LL + +DG+ T + ++ LNGH DC L
Sbjct: 647 YILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLL 706
Query: 219 KKGVYLHMPNKY 230
KG + +K+
Sbjct: 707 NKGANVDAKDKW 718
Score = 67.3 bits (157), Expect = 6e-10
Identities = 38/131 (29%), Positives = 65/131 (49%), Gaps = 2/131 (1%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T LH AA + + + L+D G ++ N G TPLH+A G + +V A
Sbjct: 241 TPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQ 300
Query: 160 ADNEDRTPMHLAAENGHAAI-IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF 218
+ + TP+H AA + H A+ +ELL A + ++KDG T +H+ +L+G + +
Sbjct: 301 KNEKGFTPLHFAAASTHGALCLELLVGN-GADVNMKSKDGKTPLHMTALHGRFSRSQTII 359
Query: 219 KKGVYLHMPNK 229
+ G + +K
Sbjct: 360 QSGAVIDCEDK 370
Score = 63.7 bits (148), Expect = 7e-09
Identities = 58/216 (26%), Positives = 101/216 (46%), Gaps = 16/216 (7%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL A G+ ++ ELL A ++ A T LH A + ++L+ + A
Sbjct: 75 RTPLHAAAYLGDAEII-ELLILSGA-RVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSAD 132
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
V+A + QTPLHIAAA + + +N ++D RT +H AA +GH +++LL
Sbjct: 133 VNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLL 192
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDEVLFVK 243
+ A+I K +H A+ GH + +L G + +K+++ L
Sbjct: 193 LSR-GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK----DKKSYTP-LHAA 246
Query: 244 IENGLIKGLKSDDGSYSMFLGIPYALVNESNPFGDS 279
+G+I +K Y + LG+ +NE N +G++
Sbjct: 247 ASSGMISVVK-----YLLDLGVD---MNEPNAYGNT 274
Score = 62.5 bits (145), Expect = 2e-08
Identities = 47/160 (29%), Positives = 76/160 (47%), Gaps = 7/160 (4%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G+ + L+ Q+ L +G T L LAA + V+ +L++ GA +
Sbjct: 586 PLHLAAYHGHHQALEVLV--QSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASIL 643
Query: 126 ATNGA-GQTPLHIAAAEGDEPLVKYFYGVRA--NAA-IADNEDRTPMHLAAENGHAAIIE 181
+ +TP+H AA G ++ G NA I D +TP+ L+ NGH +
Sbjct: 644 VKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVY 703
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L +K A++ + K G T +H ++ GH +C L + G
Sbjct: 704 SLLNK-GANVDAKDKWGRTALHRGAVTGHEECVDALLQHG 742
Score = 58.0 bits (134), Expect = 3e-07
Identities = 39/131 (29%), Positives = 61/131 (46%), Gaps = 3/131 (2%)
Query: 54 LIRDLVFQRGKVPLLLAVEAGNQSMVRELL-SAQTAEQLKATTPAGDTALHLAARRRDVD 112
L++D + +R P+ A G+ +R L+ +A+ + G T L L+ D
Sbjct: 643 LVKDYILKR--TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTD 700
Query: 113 MARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA 172
L++ GA VDA + G+T LH A G E V A + D+ RTP+HL+A
Sbjct: 701 CVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSA 760
Query: 173 ENGHAAIIELL 183
GH ++ L
Sbjct: 761 ACGHIGVLGAL 771
Score = 52.4 bits (120), Expect = 2e-05
Identities = 42/146 (28%), Positives = 68/146 (46%), Gaps = 3/146 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A G++ ++ L+++ A+ K G LHLAA D R L+
Sbjct: 370 KNGNTPLHIAARYGHELLINTLITSG-ADTAKRGIH-GMFPLHLAALSGFSDCCRKLLSS 427
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G +D + G+T LH AAA G+ + A+ D R+P+H AA N + +
Sbjct: 428 GFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCL 487
Query: 181 ELLADKFKASIFERTKDGSTLMHIAS 206
L AS+ + + G T +H A+
Sbjct: 488 FALVGS-GASVNDLDERGCTPLHYAA 512
Score = 52.0 bits (119), Expect = 2e-05
Identities = 30/116 (25%), Positives = 56/116 (48%)
Query: 102 LHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIAD 161
L L A +D+ + D+ N A +PLH+AA G ++ + + +
Sbjct: 554 LQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRN 613
Query: 162 NEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+ RTP+ LAA GH +++L ++ + + + T +H A+ NGH++C +L
Sbjct: 614 SSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLL 669
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/110 (31%), Positives = 53/110 (48%), Gaps = 5/110 (4%)
Query: 110 DVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTP 167
D D R L+ V+ + +TPLH AA GD +++ G R NA D++ TP
Sbjct: 53 DPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNA--KDSKWLTP 110
Query: 168 MHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+H A + +++L K A + R K+ T +HIA+ N CA L
Sbjct: 111 LHRAVASCSEEAVQVLL-KHSADVNARDKNWQTPLHIAAANKAVKCAEAL 159
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/102 (25%), Positives = 46/102 (45%), Gaps = 2/102 (1%)
Query: 1323 HGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAP 1382
+G V L+ + ++N D TPLH AA G +++LL SGA ++ + P
Sbjct: 51 NGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTP 110
Query: 1383 IWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKN 1424
+ A + + ++ LL +H DK + L + + N
Sbjct: 111 LHRAVASCSEEAVQVLL--KHSADVNARDKNWQTPLHIAAAN 150
Score = 35.9 bits (79), Expect = 1.6
Identities = 20/46 (43%), Positives = 24/46 (52%)
Query: 138 AAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
A GD V+ + + DNE RTP+H AA G A IIELL
Sbjct: 48 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELL 93
>BC113868-1|AAI13869.1| 782|Homo sapiens ANKRD28 protein protein.
Length = 782
Score = 217 bits (531), Expect = 3e-55
Identities = 218/752 (28%), Positives = 331/752 (44%), Gaps = 76/752 (10%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA G II L+ G V+ + T LH AV SC V+ LL + ADV+ R
Sbjct: 75 LHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARD 134
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
K +TPLHIAA KCA L+ + N + G T +H AA G+ + LLL
Sbjct: 135 -KNWQTPLHIAAA-NKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSR 192
Query: 787 GGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDED 846
G + + +D + A ++V+ L+ H E + D+
Sbjct: 193 GAN------INAFDK-KDRRAIHWAAYMGHIEVVKLLVS----HGAE------VTCKDKK 235
Query: 847 GASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVM 906
+ LH A + VVK L++ G D++ + + T H G + V+
Sbjct: 236 SYTPLHAAAS---------SGMISVVKYLLDLGVDMNEPNAYGN-TPLHVACYNGQDVVV 285
Query: 907 TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLT-NHARVDVFDVEGRSA 965
E+I D +N++N G+TPL A H L LL N A V++ +G++
Sbjct: 286 NELI------DCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTP 339
Query: 966 LHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVL 1025
LH+ A HG ++ + A I+ + +NG T LH+AA G+ L+ LI A
Sbjct: 340 LHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITS-GADTAKR 398
Query: 1026 TLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQH 1085
+ PLHLAA SG + C+ LL G +ID D+ G+ +HAAA E + L L
Sbjct: 399 GIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTG 458
Query: 1086 PNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDS--TPLQLAAEGG 1143
+ K G + H AA + + + F G ++ N L++ TPL AA
Sbjct: 459 ADF-NKKDKFGRSPLHYAAANCNYQCL-----FALVGSGASVNDLDERGCTPLHYAATSD 512
Query: 1144 -HADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRS------------TNTL 1190
+ L+R A+ ++ G AVH +A +GH L ++ S T+ L
Sbjct: 513 TDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDML 572
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPV-LGAESGLTPLH 1249
S + ++PLH+AAY+G + + L+ SL+ + + SG TPL
Sbjct: 573 SDSDNRATISPLHLAAYHGHHQALEVLVQ--------------SLLDLDVRNSSGRTPLD 618
Query: 1250 LAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSA--ELLH 1307
LAA+ G+ V +L+N G P+H A GH + LL+ + +
Sbjct: 619 LAAFKGHVECVDVLINQ-GASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVD 677
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
D +G+T L ++ +GH V LL +GA ++A DK G T LH A GH V L +
Sbjct: 678 IQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQ 737
Query: 1368 SGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
GA + PI +A+ H VL LL
Sbjct: 738 HGAKCLLRDSRGRTPIHLSAACGHIGVLGALL 769
Score = 217 bits (530), Expect = 4e-55
Identities = 212/718 (29%), Positives = 328/718 (45%), Gaps = 64/718 (8%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H A + LL+ V+ + T LHIA + E L+ ++V++
Sbjct: 108 LHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSD 167
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
R T LH AA G+ L LL GA N + +H AA G++ + LL+
Sbjct: 168 RAGR-TALHHAAFSGHGEMVKL-LLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSH 225
Query: 787 GGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDED 846
G + K K TPL A S M +V++L++ D ++ +
Sbjct: 226 GAEVTCKDK-------KSYTPLHAAASSGMISVVKYLLDLGVD----------MNEPNAY 268
Query: 847 GASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVM 906
G + LH AC ++V VV LI+ GA V+ Q T H+ A + + +
Sbjct: 269 GNTPLHVAC-YNGQDV--------VVNELIDCGAIVN-QKNEKGFTPLHFAAASTHGALC 318
Query: 907 TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSAL 966
E++ + ADV N ++ G TPL + G T++ + A +D D G + L
Sbjct: 319 LELLVG-NGADV----NMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPL 373
Query: 967 HLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
H+AA +G+ + + L+T+ A + +G LHLAA++G++ + L+ ID
Sbjct: 374 HIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSS-GFDIDTPD 432
Query: 1027 LKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN-NYSEVVQLFLQQH 1085
+T LH AAA G +E LLL GA+ + D+ G+ P+H AA N NY + L
Sbjct: 433 DFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGA 492
Query: 1086 PNLVMATTKDGNTCAHIAAIQGSV-KVIEELMKFDRTGVISAR---NKLNDSTP------ 1135
V + G T H AA + K +E L++ D I + N ++ S
Sbjct: 493 S--VNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLC 550
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM-RSTNTLRISS 1194
LQL A DV+ +NRA ++ +HLAA HGH L+V+ +S L + +
Sbjct: 551 LQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRN 610
Query: 1195 KKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYN 1254
G TPL +AA+ G E V L++ G S++ V TP+H AA N
Sbjct: 611 SS-GRTPLDLAAFKGHVECVDVLINQ-----------GASIL-VKDYILKRTPIHAAATN 657
Query: 1255 GNENVVRLLLNSAGVQ-ADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHG 1313
G+ +RLL+ +A Q A + NG PL L+ GH V LL++ A + + D+ G
Sbjct: 658 GHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANV-DAKDKWG 716
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGAS 1371
+T LH + GH + V+ LL GA+ D G TP+H +A GH+ V+ L +S AS
Sbjct: 717 RTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAAS 774
Score = 198 bits (483), Expect = 2e-49
Identities = 193/685 (28%), Positives = 307/685 (44%), Gaps = 58/685 (8%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA V L+ +V+V+ TALH A S +V+ LL GA+++
Sbjct: 141 LHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFD 200
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
K R +H AA + + L L+ GA + TP+H AA G ++ + LL+
Sbjct: 201 KKDRRA-IHWAAYMGHIEVVKL-LVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDL 258
Query: 787 GGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDED 846
G D G TPL +AC + +V LI+ A ++ +E
Sbjct: 259 GVDMNEPN-------AYGNTPLHVACYNGQDVVVNELID----------CGAIVNQKNEK 301
Query: 847 GASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVM 906
G + LH+A T + ++ L+ NGADV+++++ + +T H A+ G
Sbjct: 302 GFTPLHFAAASTHGAL--------CLELLVGNGADVNMKSK-DGKTPLHMTALHGRFSRS 352
Query: 907 TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSAL 966
+I + D ++ G TPL IA GH L+NTL+T+ A + G L
Sbjct: 353 QTIIQSGAVIDC------EDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPL 406
Query: 967 HLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
HLAA G+ C LL++ I++ GRT LH AA G + L+ + A +
Sbjct: 407 HLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLL-NTGADFNKKD 465
Query: 1027 LKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP 1086
++PLH AAA+ + L+ GA+++ DE G P+H AA ++ +L ++
Sbjct: 466 KFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRND 525
Query: 1087 NLVMATTKDGNTCAHIAAIQG---------SVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
K G H +A G S ++ LM+ T ++S + +PL
Sbjct: 526 ANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLH 585
Query: 1138 LAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTN-TLRISSKK 1196
LAA GH + VLV++ N +G T + LAA GH +DV+ + ++ +
Sbjct: 586 LAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYI 645
Query: 1197 LGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGN 1256
L TP+H AA G +E +R L+ + +E V + +G TPL L+ NG+
Sbjct: 646 LKRTPIHAAATNGHSECLRLLIGN------AEPQNAVDIQD----GNGQTPLMLSVLNGH 695
Query: 1257 ENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTG 1316
+ V LLN G D A ++ G LH GH V LL A+ L D G+T
Sbjct: 696 TDCVYSLLNK-GANVD-AKDKWGRTALHRGAVTGHEECVDALLQHGAKCL-LRDSRGRTP 752
Query: 1317 LHIASTHGHYQMVEVLLGQGAEINA 1341
+H+++ GH ++ LL A ++A
Sbjct: 753 IHLSAACGHIGVLGALLQSAASMDA 777
Score = 180 bits (437), Expect = 7e-44
Identities = 183/732 (25%), Positives = 324/732 (44%), Gaps = 55/732 (7%)
Query: 679 INTLLQKGESVDVTTNDNYT-ALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIA 737
I+ L Q+ +S+ + N +L A+ + P V L+ DV+ + ++R TPLH A
Sbjct: 20 ISKLPQENKSLHSPPSGNVLPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKR-TPLHAA 78
Query: 738 ARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVC 797
A + D + L++L SGA N +TP+H A + + +LL+ D + K
Sbjct: 79 AYLGDAEIIELLIL-SGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDK-- 135
Query: 798 IYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKV 857
+TPL +A + L+ + + ++ D G +ALH+A
Sbjct: 136 -----NWQTPLHIAAANKAVKCAEALVPLLSN----------VNVSDRAGRTALHHAAF- 179
Query: 858 TKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTAD 917
+ ++VK L+ GA+++ + + A H+ A G+ +V+ +++H A+
Sbjct: 180 --------SGHGEMVKLLLSRGANINAFDKKDRR-AIHWAAYMGHIEVVKLLVSH--GAE 228
Query: 918 VSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQV 977
V+ ++ +TPL A G + +V LL ++ + G + LH+A +G V
Sbjct: 229 VTC----KDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVV 284
Query: 978 CDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAA 1037
+ L+ A +N K G T LH AA + + L L+ + A +++ + +TPLH+ A
Sbjct: 285 VNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTA 344
Query: 1038 ASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGN 1097
G+ + +++ GA ID D+ G P+H AA+ + ++ + + G
Sbjct: 345 LHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGI-HGM 403
Query: 1098 TCAHIAAIQGSVKVIEELMK--FDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAG 1155
H+AA+ G +L+ FD I + T L AA GG+ + + +L+ G
Sbjct: 404 FPLHLAALSGFSDCCRKLLSSGFD----IDTPDDFG-RTCLHAAAAGGNLECLNLLLNTG 458
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
A +++ G + +H AA + + L + + + G TPLH AA
Sbjct: 459 ADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCL 518
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGV-QADAA 1274
E L G + V A L L A +E + +L+ ++G +
Sbjct: 519 EYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIA---SETPLDVLMETSGTDMLSDS 575
Query: 1275 SNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG 1334
N +PLHLA + GH + +L+ + L + G+T L +A+ GH + V+VL+
Sbjct: 576 DNRATISPLHLAAYHGHHQALEVLVQSLLD-LDVRNSSGRTPLDLAAFKGHVECVDVLIN 634
Query: 1335 QGAEINATDK-NGWTPLHCAAKAGHLNVVKLLCESGASPKSETNL----NCAPIWFAASE 1389
QGA I D TP+H AA GH ++LL A P++ ++ P+ +
Sbjct: 635 QGASILVKDYILKRTPIHAAATNGHSECLRLLI-GNAEPQNAVDIQDGNGQTPLMLSVLN 693
Query: 1390 NHNDVLEYLLHK 1401
H D + LL+K
Sbjct: 694 GHTDCVYSLLNK 705
Score = 174 bits (424), Expect = 2e-42
Identities = 133/421 (31%), Positives = 192/421 (45%), Gaps = 20/421 (4%)
Query: 984 NKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIE 1043
NK+ + + N +L A NG V+ LI ++ +K+TPLH AA G E
Sbjct: 27 NKSLHSPPSGNVLPSLVQAIFNGDPDEVRALIFKKED-VNFQDNEKRTPLHAAAYLGDAE 85
Query: 1044 VCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIA 1103
+ +LL+ GA ++A D P+H A + E VQ+ L+ H V A K+ T HIA
Sbjct: 86 IIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLK-HSADVNARDKNWQTPLHIA 144
Query: 1104 AIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENR 1163
A +VK E L+ +S R T L AA GH ++V++L+ GA+ ++
Sbjct: 145 AANKAVKCAEALVPLLSNVNVSDRA---GRTALHHAAFSGHGEMVKLLLSRGANINAFDK 201
Query: 1164 AGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPG 1223
A+H AA GH V+ ++ S K TPLH AA G V+ LL
Sbjct: 202 KDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDL--- 258
Query: 1224 TVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPL 1283
V P G TPLH+A YNG + VV L++ + NE G+ PL
Sbjct: 259 GVDMNEPNAY----------GNTPLHVACYNGQDVVVNELIDCGAIVNQ--KNEKGFTPL 306
Query: 1284 HLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATD 1343
H A H ++ LL + ++ + GKT LH+ + HG + + ++ GA I+ D
Sbjct: 307 HFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCED 366
Query: 1344 KNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEH 1403
KNG TPLH AA+ GH ++ L SGA P+ AA +D LL
Sbjct: 367 KNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGF 426
Query: 1404 D 1404
D
Sbjct: 427 D 427
Score = 163 bits (397), Expect = 5e-39
Identities = 126/425 (29%), Positives = 200/425 (47%), Gaps = 20/425 (4%)
Query: 980 ALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAAS 1039
AL+ K +N + RT LH AA G A +++ LI A ++ K TPLH A AS
Sbjct: 56 ALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILS-GARVNAKDSKWLTPLHRAVAS 114
Query: 1040 GQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTC 1099
E ++LL+ A+++A D+ Q P+H AA N + + + N V + + G T
Sbjct: 115 CSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSN-VNVSDRAGRTA 173
Query: 1100 AHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
H AA G ++++ L+ R I+A +K D + AA GH +VV++LV GA T
Sbjct: 174 LHHAAFSGHGEMVKLLLS--RGANINAFDK-KDRRAIHWAAYMGHIEVVKLLVSHGAEVT 230
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
+++ T +H AA G +V+ + G TPLH+A Y GQ V EL+
Sbjct: 231 CKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELID 290
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G + ++ E G TPLH AA + + + LL G + S + G
Sbjct: 291 C--GAIVNQKN-----------EKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD-G 336
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
PLH+ G S ++ +S ++ D++G T LHIA+ +GH ++ L+ GA+
Sbjct: 337 KTPLHMTALHGRFSRSQTII-QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADT 395
Query: 1340 NATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+G PLH AA +G + + L SG + + + AA+ + + L LL
Sbjct: 396 AKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLL 455
Query: 1400 HKEHD 1404
+ D
Sbjct: 456 NTGAD 460
Score = 163 bits (395), Expect = 8e-39
Identities = 136/468 (29%), Positives = 213/468 (45%), Gaps = 38/468 (8%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K DG +H A +G T++Q G +D + T LHIA ++ TL+
Sbjct: 332 KSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITS 391
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
GAD R G PLH+AA D C LL SG + + G T +H AA GNL
Sbjct: 392 GADTAKR-GIHGMFPLHLAALSGFSD-CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLE 449
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
L LLL G D +K K G +PL A +C + L+ S A
Sbjct: 450 CLNLLLNTGADFNKKDKF-------GRSPLHYAAANCNYQCLFALVG----------SGA 492
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
++ +DE G + LHYA T + D + ++ L+ N A+ ++ + + A HY A
Sbjct: 493 SVNDLDERGCTPLHYA--ATSD------TDGKCLEYLLRNDANPGIRDKQGY-NAVHYSA 543
Query: 899 IAGNNDVM------TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
G+ + T + + T+ + N +PL +A + GH Q + L+ +
Sbjct: 544 AYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSL 603
Query: 953 ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKAR-NGRTALHLAAMNGYAHLV 1011
+DV + GR+ L LAA G+++ D L+ A I K RT +H AA NG++ +
Sbjct: 604 LDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECL 663
Query: 1012 KFLI--RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA 1069
+ LI + +D+ QTPL L+ +G + LL GAN+DA D+ G+ +H
Sbjct: 664 RLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRG 723
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMK 1117
A + E V LQ ++ ++ G T H++A G + V+ L++
Sbjct: 724 AVTGHEECVDALLQHGAKCLLRDSR-GRTPIHLSAACGHIGVLGALLQ 770
Score = 153 bits (372), Expect = 5e-36
Identities = 170/620 (27%), Positives = 279/620 (45%), Gaps = 69/620 (11%)
Query: 665 RSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHI 724
R+IH AA GH+ ++ L+ G V +YT LH A S +VV+ LL G D++
Sbjct: 205 RAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN- 263
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA-TLVLL 783
TPLH+A D L+ GA N+ E G TP+H AA + A L LL
Sbjct: 264 EPNAYGNTPLHVAC-YNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELL 322
Query: 784 LEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAV 843
+ +G D K+K G+TPL M + +I+ S A ID
Sbjct: 323 VGNGADVNMKSK-------DGKTPLHMTALHGRFSRSQTIIQ----------SGAVIDCE 365
Query: 844 DEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN 903
D++G + LH A + E ++ LI +GAD + + H H A++G +
Sbjct: 366 DKNGNTPLHIAARYGHE---------LLINTLITSGADTAKRGIHG-MFPLHLAALSGFS 415
Query: 904 DVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGR 963
D ++++ S D+ + + G T L A G+++ +N LL A + D GR
Sbjct: 416 DCCRKLLS--SGFDI----DTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGR 469
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY-AHLVKFLIRDHNAMI 1022
S LH AA + Q AL+ + A +N G T LH AA + +++L+R ++A
Sbjct: 470 SPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLR-NDANP 528
Query: 1023 DVLTLKKQTPLHLAAASG-----QIEVCKLLLELGANIDATDELGQ-------KPIHAAA 1070
+ + +H +AA G Q+ + L++ TD L P+H AA
Sbjct: 529 GIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAA 588
Query: 1071 QNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKL 1130
+ + + +++ +Q +L + + G T +AA +G V+ ++ L+ ++ I ++ +
Sbjct: 589 YHGHHQALEVLVQSLLDLDVRNS-SGRTPLDLAAFKGHVECVDVLI--NQGASILVKDYI 645
Query: 1131 NDSTPLQLAAEGGHADVVRVLV--RAGASCTD-ENRAGLTAVHLAAEHGHTNVLDVMRST 1187
TP+ AA GH++ +R+L+ + D ++ G T + L+ +GHT+ + + +
Sbjct: 646 LKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNK 705
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+ K G T LH A G E V LL H G +L G TP
Sbjct: 706 GANVDAKDKWGRTALHRGAVTGHEECVDALLQH-----------GAKC--LLRDSRGRTP 752
Query: 1248 LHLAAYNGNENVVRLLLNSA 1267
+HL+A G+ V+ LL SA
Sbjct: 753 IHLSAACGHIGVLGALLQSA 772
Score = 132 bits (318), Expect = 2e-29
Identities = 110/372 (29%), Positives = 174/372 (46%), Gaps = 23/372 (6%)
Query: 1036 AAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKD 1095
A +G + + L+ +++ D + P+HAAA +E+++L + V A
Sbjct: 45 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGAR-VNAKDSK 103
Query: 1096 GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAG 1155
T H A S + ++ L+K + ++AR+K N TPL +AA LV
Sbjct: 104 WLTPLHRAVASCSEEAVQVLLK--HSADVNARDK-NWQTPLHIAAANKAVKCAEALVPLL 160
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
++ +RAG TA+H AA GH ++ ++ S + K +H AAY G E V+
Sbjct: 161 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 220
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS 1275
L+SH + + TPLH AA +G +VV+ LL+ GV +
Sbjct: 221 LLVSHGAEVTCKD-------------KKSYTPLHAAASSGMISVVKYLLD-LGVDMNEP- 265
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIA--STHGHYQMVEVLL 1333
N G PLH+AC+ G +V L+ A +++ + G T LH A STHG +E+L+
Sbjct: 266 NAYGNTPLHVACYNGQDVVVNELIDCGA-IVNQKNEKGFTPLHFAAASTHGAL-CLELLV 323
Query: 1334 GQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHND 1393
G GA++N K+G TPLH A G + + + +SGA E P+ AA H
Sbjct: 324 GNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHEL 383
Query: 1394 VLEYLLHKEHDT 1405
++ L+ DT
Sbjct: 384 LINTLITSGADT 395
Score = 72.5 bits (170), Expect = 1e-11
Identities = 52/165 (31%), Positives = 79/165 (47%), Gaps = 3/165 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL AV + ++ V+ LL + + + A T LH+AA + V A LV + V+
Sbjct: 107 PLHRAVASCSEEAVQVLL--KHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVN 164
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
++ AG+T LH AA G +VK AN D +DR +H AA GH +++LL
Sbjct: 165 VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLV- 223
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
A + + K T +H A+ +G L GV ++ PN Y
Sbjct: 224 SHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAY 268
Score = 71.7 bits (168), Expect = 3e-11
Identities = 49/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L A +G+ MV+ LLS + A A+H AA +++ ++LV +GA
Sbjct: 170 GRTALHHAAFSGHGEMVKLLLSR--GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA 227
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V + TPLH AA+ G +VKY + + + TP+H+A NG ++
Sbjct: 228 EVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNE 287
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGH-ADCAMMLFKKGVYLHMPNK 229
L D A + ++ + G T +H A+ + H A C +L G ++M +K
Sbjct: 288 LID-CGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSK 334
Score = 70.1 bits (164), Expect = 8e-11
Identities = 49/171 (28%), Positives = 80/171 (46%), Gaps = 4/171 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL A + + ++ ELL A+ + + G T LH+ A ++ ++
Sbjct: 300 EKGFTPLHFAAASTHGALCLELLVGNGAD-VNMKSKDGKTPLHMTALHGRFSRSQTIIQS 358
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA-AI 179
GAV+D + G TPLHIAA G E L+ A+ A P+HLAA +G +
Sbjct: 359 GAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCC 418
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
+LL+ F I G T +H A+ G+ +C +L G + +K+
Sbjct: 419 RKLLSSGF--DIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKF 467
Score = 67.7 bits (158), Expect = 4e-10
Identities = 43/132 (32%), Positives = 63/132 (47%), Gaps = 3/132 (2%)
Query: 102 LHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIAD 161
LHLAA +LV +D N +G+TPL +AA +G V A+ + D
Sbjct: 584 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 643
Query: 162 NE-DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGS--TLMHIASLNGHADCAMMLF 218
RTP+H AA NGH+ + LL + +DG+ T + ++ LNGH DC L
Sbjct: 644 YILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLL 703
Query: 219 KKGVYLHMPNKY 230
KG + +K+
Sbjct: 704 NKGANVDAKDKW 715
Score = 67.3 bits (157), Expect = 6e-10
Identities = 38/131 (29%), Positives = 65/131 (49%), Gaps = 2/131 (1%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T LH AA + + + L+D G ++ N G TPLH+A G + +V A
Sbjct: 238 TPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQ 297
Query: 160 ADNEDRTPMHLAAENGHAAI-IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF 218
+ + TP+H AA + H A+ +ELL A + ++KDG T +H+ +L+G + +
Sbjct: 298 KNEKGFTPLHFAAASTHGALCLELLVGN-GADVNMKSKDGKTPLHMTALHGRFSRSQTII 356
Query: 219 KKGVYLHMPNK 229
+ G + +K
Sbjct: 357 QSGAVIDCEDK 367
Score = 64.1 bits (149), Expect = 5e-09
Identities = 68/265 (25%), Positives = 120/265 (45%), Gaps = 22/265 (8%)
Query: 17 SSGVRSPPANQQKDLQRLELSFIELNKERAKQKEWKKLIRDLVFQRG--KVPLLLAVEAG 74
+ + SPP+ L L + + + + +KK D+ FQ + PL A G
Sbjct: 27 NKSLHSPPSGNV--LPSLVQAIFNGDPDEVRALIFKK--EDVNFQDNEKRTPLHAAAYLG 82
Query: 75 NQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTP 134
+ ++ ELL A ++ A T LH A + ++L+ + A V+A + QTP
Sbjct: 83 DAEII-ELLILSGA-RVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTP 140
Query: 135 LHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFER 194
LHIAAA + + +N ++D RT +H AA +GH +++LL + A+I
Sbjct: 141 LHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSR-GANINAF 199
Query: 195 TKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDEVLFVKIENGLIKGLKS 254
K +H A+ GH + +L G + +K+++ L +G+I +K
Sbjct: 200 DKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK----DKKSYTP-LHAAASSGMISVVK- 253
Query: 255 DDGSYSMFLGIPYALVNESNPFGDS 279
Y + LG+ +NE N +G++
Sbjct: 254 ----YLLDLGVD---MNEPNAYGNT 271
Score = 62.5 bits (145), Expect = 2e-08
Identities = 47/160 (29%), Positives = 76/160 (47%), Gaps = 7/160 (4%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G+ + L+ Q+ L +G T L LAA + V+ +L++ GA +
Sbjct: 583 PLHLAAYHGHHQALEVLV--QSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASIL 640
Query: 126 ATNGA-GQTPLHIAAAEGDEPLVKYFYGVRA--NAA-IADNEDRTPMHLAAENGHAAIIE 181
+ +TP+H AA G ++ G NA I D +TP+ L+ NGH +
Sbjct: 641 VKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVY 700
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L +K A++ + K G T +H ++ GH +C L + G
Sbjct: 701 SLLNK-GANVDAKDKWGRTALHRGAVTGHEECVDALLQHG 739
Score = 58.0 bits (134), Expect = 3e-07
Identities = 39/131 (29%), Positives = 61/131 (46%), Gaps = 3/131 (2%)
Query: 54 LIRDLVFQRGKVPLLLAVEAGNQSMVRELL-SAQTAEQLKATTPAGDTALHLAARRRDVD 112
L++D + +R P+ A G+ +R L+ +A+ + G T L L+ D
Sbjct: 640 LVKDYILKR--TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTD 697
Query: 113 MARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA 172
L++ GA VDA + G+T LH A G E V A + D+ RTP+HL+A
Sbjct: 698 CVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSA 757
Query: 173 ENGHAAIIELL 183
GH ++ L
Sbjct: 758 ACGHIGVLGAL 768
Score = 52.4 bits (120), Expect = 2e-05
Identities = 42/146 (28%), Positives = 68/146 (46%), Gaps = 3/146 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A G++ ++ L+++ A+ K G LHLAA D R L+
Sbjct: 367 KNGNTPLHIAARYGHELLINTLITSG-ADTAKRGIH-GMFPLHLAALSGFSDCCRKLLSS 424
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G +D + G+T LH AAA G+ + A+ D R+P+H AA N + +
Sbjct: 425 GFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCL 484
Query: 181 ELLADKFKASIFERTKDGSTLMHIAS 206
L AS+ + + G T +H A+
Sbjct: 485 FALVGS-GASVNDLDERGCTPLHYAA 509
Score = 52.0 bits (119), Expect = 2e-05
Identities = 30/116 (25%), Positives = 56/116 (48%)
Query: 102 LHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIAD 161
L L A +D+ + D+ N A +PLH+AA G ++ + + +
Sbjct: 551 LQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRN 610
Query: 162 NEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+ RTP+ LAA GH +++L ++ + + + T +H A+ NGH++C +L
Sbjct: 611 SSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLL 666
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/102 (25%), Positives = 46/102 (45%), Gaps = 2/102 (1%)
Query: 1323 HGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAP 1382
+G V L+ + ++N D TPLH AA G +++LL SGA ++ + P
Sbjct: 48 NGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTP 107
Query: 1383 IWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKN 1424
+ A + + ++ LL +H DK + L + + N
Sbjct: 108 LHRAVASCSEEAVQVLL--KHSADVNARDKNWQTPLHIAAAN 147
>BC106948-1|AAI06949.2| 785|Homo sapiens ANKRD28 protein protein.
Length = 785
Score = 217 bits (531), Expect = 3e-55
Identities = 218/752 (28%), Positives = 331/752 (44%), Gaps = 76/752 (10%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA G II L+ G V+ + T LH AV SC V+ LL + ADV+ R
Sbjct: 78 LHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARD 137
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
K +TPLHIAA KCA L+ + N + G T +H AA G+ + LLL
Sbjct: 138 -KNWQTPLHIAAA-NKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSR 195
Query: 787 GGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDED 846
G + + +D + A ++V+ L+ H E + D+
Sbjct: 196 GAN------INAFDK-KDRRAIHWAAYMGHIEVVKLLVS----HGAE------VTCKDKK 238
Query: 847 GASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVM 906
+ LH A + VVK L++ G D++ + + T H G + V+
Sbjct: 239 SYTPLHAAAS---------SGMISVVKYLLDLGVDMNEPNAYGN-TPLHVACYNGQDVVV 288
Query: 907 TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLT-NHARVDVFDVEGRSA 965
E+I D +N++N G+TPL A H L LL N A V++ +G++
Sbjct: 289 NELI------DCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTP 342
Query: 966 LHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVL 1025
LH+ A HG ++ + A I+ + +NG T LH+AA G+ L+ LI A
Sbjct: 343 LHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITS-GADTAKR 401
Query: 1026 TLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQH 1085
+ PLHLAA SG + C+ LL G +ID D+ G+ +HAAA E + L L
Sbjct: 402 GIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTG 461
Query: 1086 PNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDS--TPLQLAAEGG 1143
+ K G + H AA + + + F G ++ N L++ TPL AA
Sbjct: 462 ADF-NKKDKFGRSPLHYAAANCNYQCL-----FALVGSGASVNDLDERGCTPLHYAATSD 515
Query: 1144 -HADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRS------------TNTL 1190
+ L+R A+ ++ G AVH +A +GH L ++ S T+ L
Sbjct: 516 TDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDML 575
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPV-LGAESGLTPLH 1249
S + ++PLH+AAY+G + + L+ SL+ + + SG TPL
Sbjct: 576 SDSDNRATISPLHLAAYHGHHQALEVLVQ--------------SLLDLDVRNSSGRTPLD 621
Query: 1250 LAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSA--ELLH 1307
LAA+ G+ V +L+N G P+H A GH + LL+ + +
Sbjct: 622 LAAFKGHVECVDVLINQ-GASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVD 680
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
D +G+T L ++ +GH V LL +GA ++A DK G T LH A GH V L +
Sbjct: 681 IQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQ 740
Query: 1368 SGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
GA + PI +A+ H VL LL
Sbjct: 741 HGAKCLLRDSRGRTPIHLSAACGHIGVLGALL 772
Score = 217 bits (530), Expect = 4e-55
Identities = 212/718 (29%), Positives = 328/718 (45%), Gaps = 64/718 (8%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H A + LL+ V+ + T LHIA + E L+ ++V++
Sbjct: 111 LHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSD 170
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
R T LH AA G+ L LL GA N + +H AA G++ + LL+
Sbjct: 171 RAGR-TALHHAAFSGHGEMVKL-LLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSH 228
Query: 787 GGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDED 846
G + K K TPL A S M +V++L++ D ++ +
Sbjct: 229 GAEVTCKDK-------KSYTPLHAAASSGMISVVKYLLDLGVD----------MNEPNAY 271
Query: 847 GASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVM 906
G + LH AC ++V VV LI+ GA V+ Q T H+ A + + +
Sbjct: 272 GNTPLHVAC-YNGQDV--------VVNELIDCGAIVN-QKNEKGFTPLHFAAASTHGALC 321
Query: 907 TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSAL 966
E++ + ADV N ++ G TPL + G T++ + A +D D G + L
Sbjct: 322 LELLVG-NGADV----NMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPL 376
Query: 967 HLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
H+AA +G+ + + L+T+ A + +G LHLAA++G++ + L+ ID
Sbjct: 377 HIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSS-GFDIDTPD 435
Query: 1027 LKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN-NYSEVVQLFLQQH 1085
+T LH AAA G +E LLL GA+ + D+ G+ P+H AA N NY + L
Sbjct: 436 DFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGA 495
Query: 1086 PNLVMATTKDGNTCAHIAAIQGSV-KVIEELMKFDRTGVISAR---NKLNDSTP------ 1135
V + G T H AA + K +E L++ D I + N ++ S
Sbjct: 496 S--VNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLC 553
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM-RSTNTLRISS 1194
LQL A DV+ +NRA ++ +HLAA HGH L+V+ +S L + +
Sbjct: 554 LQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRN 613
Query: 1195 KKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYN 1254
G TPL +AA+ G E V L++ G S++ V TP+H AA N
Sbjct: 614 SS-GRTPLDLAAFKGHVECVDVLINQ-----------GASIL-VKDYILKRTPIHAAATN 660
Query: 1255 GNENVVRLLLNSAGVQ-ADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHG 1313
G+ +RLL+ +A Q A + NG PL L+ GH V LL++ A + + D+ G
Sbjct: 661 GHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANV-DAKDKWG 719
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGAS 1371
+T LH + GH + V+ LL GA+ D G TP+H +A GH+ V+ L +S AS
Sbjct: 720 RTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAAS 777
Score = 198 bits (483), Expect = 2e-49
Identities = 193/685 (28%), Positives = 307/685 (44%), Gaps = 58/685 (8%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA V L+ +V+V+ TALH A S +V+ LL GA+++
Sbjct: 144 LHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFD 203
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
K R +H AA + + L L+ GA + TP+H AA G ++ + LL+
Sbjct: 204 KKDRRA-IHWAAYMGHIEVVKL-LVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDL 261
Query: 787 GGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDED 846
G D G TPL +AC + +V LI+ A ++ +E
Sbjct: 262 GVDMNEPN-------AYGNTPLHVACYNGQDVVVNELID----------CGAIVNQKNEK 304
Query: 847 GASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVM 906
G + LH+A T + ++ L+ NGADV+++++ + +T H A+ G
Sbjct: 305 GFTPLHFAAASTHGAL--------CLELLVGNGADVNMKSK-DGKTPLHMTALHGRFSRS 355
Query: 907 TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSAL 966
+I + D ++ G TPL IA GH L+NTL+T+ A + G L
Sbjct: 356 QTIIQSGAVIDC------EDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPL 409
Query: 967 HLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
HLAA G+ C LL++ I++ GRT LH AA G + L+ + A +
Sbjct: 410 HLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLL-NTGADFNKKD 468
Query: 1027 LKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP 1086
++PLH AAA+ + L+ GA+++ DE G P+H AA ++ +L ++
Sbjct: 469 KFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRND 528
Query: 1087 NLVMATTKDGNTCAHIAAIQG---------SVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
K G H +A G S ++ LM+ T ++S + +PL
Sbjct: 529 ANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLH 588
Query: 1138 LAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTN-TLRISSKK 1196
LAA GH + VLV++ N +G T + LAA GH +DV+ + ++ +
Sbjct: 589 LAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYI 648
Query: 1197 LGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGN 1256
L TP+H AA G +E +R L+ + +E V + +G TPL L+ NG+
Sbjct: 649 LKRTPIHAAATNGHSECLRLLIGN------AEPQNAVDIQD----GNGQTPLMLSVLNGH 698
Query: 1257 ENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTG 1316
+ V LLN G D A ++ G LH GH V LL A+ L D G+T
Sbjct: 699 TDCVYSLLNK-GANVD-AKDKWGRTALHRGAVTGHEECVDALLQHGAKCL-LRDSRGRTP 755
Query: 1317 LHIASTHGHYQMVEVLLGQGAEINA 1341
+H+++ GH ++ LL A ++A
Sbjct: 756 IHLSAACGHIGVLGALLQSAASMDA 780
Score = 180 bits (439), Expect = 4e-44
Identities = 184/735 (25%), Positives = 325/735 (44%), Gaps = 58/735 (7%)
Query: 679 INTLLQKGESVDVTTNDN----YTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPL 734
I+ L Q+ +S+ + N Y +L A+ + P V L+ DV+ + ++R TPL
Sbjct: 20 ISKLPQENKSLHSPPSGNVLVRYPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKR-TPL 78
Query: 735 HIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKT 794
H AA + D + L++L SGA N +TP+H A + + +LL+ D +
Sbjct: 79 HAAAYLGDAEIIELLIL-SGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARD 137
Query: 795 KVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYA 854
K +TPL +A + L+ + + ++ D G +ALH+A
Sbjct: 138 K-------NWQTPLHIAAANKAVKCAEALVPLLSN----------VNVSDRAGRTALHHA 180
Query: 855 CKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHIS 914
+ ++VK L+ GA+++ + + A H+ A G+ +V+ +++H
Sbjct: 181 AF---------SGHGEMVKLLLSRGANINAFDKKDRR-AIHWAAYMGHIEVVKLLVSH-- 228
Query: 915 TADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGY 974
A+V+ ++ +TPL A G + +V LL ++ + G + LH+A +G
Sbjct: 229 GAEVTC----KDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQ 284
Query: 975 LQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH 1034
V + L+ A +N K G T LH AA + + L L+ + A +++ + +TPLH
Sbjct: 285 DVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLH 344
Query: 1035 LAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTK 1094
+ A G+ + +++ GA ID D+ G P+H AA+ + ++ + +
Sbjct: 345 MTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGI- 403
Query: 1095 DGNTCAHIAAIQGSVKVIEELMK--FDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
G H+AA+ G +L+ FD I + T L AA GG+ + + +L+
Sbjct: 404 HGMFPLHLAALSGFSDCCRKLLSSGFD----IDTPDDFG-RTCLHAAAAGGNLECLNLLL 458
Query: 1153 RAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAE 1212
GA +++ G + +H AA + + L + + + G TPLH AA
Sbjct: 459 NTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDG 518
Query: 1213 TVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGV-QA 1271
E L G + V A L L A +E + +L+ ++G
Sbjct: 519 KCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIA---SETPLDVLMETSGTDML 575
Query: 1272 DAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEV 1331
+ N +PLHLA + GH + +L+ + L + G+T L +A+ GH + V+V
Sbjct: 576 SDSDNRATISPLHLAAYHGHHQALEVLVQSLLD-LDVRNSSGRTPLDLAAFKGHVECVDV 634
Query: 1332 LLGQGAEINATDK-NGWTPLHCAAKAGHLNVVKLLCESGASPKSETNL----NCAPIWFA 1386
L+ QGA I D TP+H AA GH ++LL A P++ ++ P+ +
Sbjct: 635 LINQGASILVKDYILKRTPIHAAATNGHSECLRLLI-GNAEPQNAVDIQDGNGQTPLMLS 693
Query: 1387 ASENHNDVLEYLLHK 1401
H D + LL+K
Sbjct: 694 VLNGHTDCVYSLLNK 708
Score = 172 bits (419), Expect = 1e-41
Identities = 123/377 (32%), Positives = 175/377 (46%), Gaps = 19/377 (5%)
Query: 1028 KKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPN 1087
+K+TPLH AA G E+ +LL+ GA ++A D P+H A + E VQ+ L+ H
Sbjct: 73 EKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLK-HSA 131
Query: 1088 LVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADV 1147
V A K+ T HIAA +VK E L+ +S R T L AA GH ++
Sbjct: 132 DVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRA---GRTALHHAAFSGHGEM 188
Query: 1148 VRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAY 1207
V++L+ GA+ ++ A+H AA GH V+ ++ S K TPLH AA
Sbjct: 189 VKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAAS 248
Query: 1208 YGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSA 1267
G V+ LL V P G TPLH+A YNG + VV L++
Sbjct: 249 SGMISVVKYLLDL---GVDMNEPNAY----------GNTPLHVACYNGQDVVVNELIDCG 295
Query: 1268 GVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQ 1327
+ NE G+ PLH A H ++ LL + ++ + GKT LH+ + HG +
Sbjct: 296 AIVNQ--KNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFS 353
Query: 1328 MVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAA 1387
+ ++ GA I+ DKNG TPLH AA+ GH ++ L SGA P+ AA
Sbjct: 354 RSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAA 413
Query: 1388 SENHNDVLEYLLHKEHD 1404
+D LL D
Sbjct: 414 LSGFSDCCRKLLSSGFD 430
Score = 163 bits (397), Expect = 5e-39
Identities = 126/425 (29%), Positives = 200/425 (47%), Gaps = 20/425 (4%)
Query: 980 ALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAAS 1039
AL+ K +N + RT LH AA G A +++ LI A ++ K TPLH A AS
Sbjct: 59 ALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILS-GARVNAKDSKWLTPLHRAVAS 117
Query: 1040 GQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTC 1099
E ++LL+ A+++A D+ Q P+H AA N + + + N V + + G T
Sbjct: 118 CSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSN-VNVSDRAGRTA 176
Query: 1100 AHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
H AA G ++++ L+ R I+A +K D + AA GH +VV++LV GA T
Sbjct: 177 LHHAAFSGHGEMVKLLLS--RGANINAFDK-KDRRAIHWAAYMGHIEVVKLLVSHGAEVT 233
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
+++ T +H AA G +V+ + G TPLH+A Y GQ V EL+
Sbjct: 234 CKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELID 293
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G + ++ E G TPLH AA + + + LL G + S + G
Sbjct: 294 C--GAIVNQKN-----------EKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD-G 339
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
PLH+ G S ++ +S ++ D++G T LHIA+ +GH ++ L+ GA+
Sbjct: 340 KTPLHMTALHGRFSRSQTII-QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADT 398
Query: 1340 NATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+G PLH AA +G + + L SG + + + AA+ + + L LL
Sbjct: 399 AKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLL 458
Query: 1400 HKEHD 1404
+ D
Sbjct: 459 NTGAD 463
Score = 163 bits (395), Expect = 8e-39
Identities = 136/468 (29%), Positives = 213/468 (45%), Gaps = 38/468 (8%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K DG +H A +G T++Q G +D + T LHIA ++ TL+
Sbjct: 335 KSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITS 394
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
GAD R G PLH+AA D C LL SG + + G T +H AA GNL
Sbjct: 395 GADTAKR-GIHGMFPLHLAALSGFSD-CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLE 452
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
L LLL G D +K K G +PL A +C + L+ S A
Sbjct: 453 CLNLLLNTGADFNKKDKF-------GRSPLHYAAANCNYQCLFALVG----------SGA 495
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
++ +DE G + LHYA T + D + ++ L+ N A+ ++ + + A HY A
Sbjct: 496 SVNDLDERGCTPLHYA--ATSD------TDGKCLEYLLRNDANPGIRDKQGY-NAVHYSA 546
Query: 899 IAGNNDVM------TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
G+ + T + + T+ + N +PL +A + GH Q + L+ +
Sbjct: 547 AYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSL 606
Query: 953 ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKAR-NGRTALHLAAMNGYAHLV 1011
+DV + GR+ L LAA G+++ D L+ A I K RT +H AA NG++ +
Sbjct: 607 LDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECL 666
Query: 1012 KFLI--RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA 1069
+ LI + +D+ QTPL L+ +G + LL GAN+DA D+ G+ +H
Sbjct: 667 RLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRG 726
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMK 1117
A + E V LQ ++ ++ G T H++A G + V+ L++
Sbjct: 727 AVTGHEECVDALLQHGAKCLLRDSR-GRTPIHLSAACGHIGVLGALLQ 773
Score = 153 bits (372), Expect = 5e-36
Identities = 170/620 (27%), Positives = 279/620 (45%), Gaps = 69/620 (11%)
Query: 665 RSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHI 724
R+IH AA GH+ ++ L+ G V +YT LH A S +VV+ LL G D++
Sbjct: 208 RAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN- 266
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA-TLVLL 783
TPLH+A D L+ GA N+ E G TP+H AA + A L LL
Sbjct: 267 EPNAYGNTPLHVAC-YNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELL 325
Query: 784 LEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAV 843
+ +G D K+K G+TPL M + +I+ S A ID
Sbjct: 326 VGNGADVNMKSK-------DGKTPLHMTALHGRFSRSQTIIQ----------SGAVIDCE 368
Query: 844 DEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN 903
D++G + LH A + E ++ LI +GAD + + H H A++G +
Sbjct: 369 DKNGNTPLHIAARYGHE---------LLINTLITSGADTAKRGIHG-MFPLHLAALSGFS 418
Query: 904 DVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGR 963
D ++++ S D+ + + G T L A G+++ +N LL A + D GR
Sbjct: 419 DCCRKLLS--SGFDI----DTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGR 472
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY-AHLVKFLIRDHNAMI 1022
S LH AA + Q AL+ + A +N G T LH AA + +++L+R ++A
Sbjct: 473 SPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLR-NDANP 531
Query: 1023 DVLTLKKQTPLHLAAASG-----QIEVCKLLLELGANIDATDELGQ-------KPIHAAA 1070
+ + +H +AA G Q+ + L++ TD L P+H AA
Sbjct: 532 GIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAA 591
Query: 1071 QNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKL 1130
+ + + +++ +Q +L + + G T +AA +G V+ ++ L+ ++ I ++ +
Sbjct: 592 YHGHHQALEVLVQSLLDLDVRNS-SGRTPLDLAAFKGHVECVDVLI--NQGASILVKDYI 648
Query: 1131 NDSTPLQLAAEGGHADVVRVLV--RAGASCTD-ENRAGLTAVHLAAEHGHTNVLDVMRST 1187
TP+ AA GH++ +R+L+ + D ++ G T + L+ +GHT+ + + +
Sbjct: 649 LKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNK 708
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+ K G T LH A G E V LL H G +L G TP
Sbjct: 709 GANVDAKDKWGRTALHRGAVTGHEECVDALLQH-----------GAKC--LLRDSRGRTP 755
Query: 1248 LHLAAYNGNENVVRLLLNSA 1267
+HL+A G+ V+ LL SA
Sbjct: 756 IHLSAACGHIGVLGALLQSA 775
Score = 132 bits (318), Expect = 2e-29
Identities = 110/372 (29%), Positives = 174/372 (46%), Gaps = 23/372 (6%)
Query: 1036 AAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKD 1095
A +G + + L+ +++ D + P+HAAA +E+++L + V A
Sbjct: 48 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGAR-VNAKDSK 106
Query: 1096 GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAG 1155
T H A S + ++ L+K + ++AR+K N TPL +AA LV
Sbjct: 107 WLTPLHRAVASCSEEAVQVLLK--HSADVNARDK-NWQTPLHIAAANKAVKCAEALVPLL 163
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
++ +RAG TA+H AA GH ++ ++ S + K +H AAY G E V+
Sbjct: 164 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 223
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS 1275
L+SH + + TPLH AA +G +VV+ LL+ GV +
Sbjct: 224 LLVSHGAEVTCKD-------------KKSYTPLHAAASSGMISVVKYLLD-LGVDMNEP- 268
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIA--STHGHYQMVEVLL 1333
N G PLH+AC+ G +V L+ A +++ + G T LH A STHG +E+L+
Sbjct: 269 NAYGNTPLHVACYNGQDVVVNELIDCGA-IVNQKNEKGFTPLHFAAASTHGAL-CLELLV 326
Query: 1334 GQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHND 1393
G GA++N K+G TPLH A G + + + +SGA E P+ AA H
Sbjct: 327 GNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHEL 386
Query: 1394 VLEYLLHKEHDT 1405
++ L+ DT
Sbjct: 387 LINTLITSGADT 398
Score = 72.5 bits (170), Expect = 1e-11
Identities = 52/165 (31%), Positives = 79/165 (47%), Gaps = 3/165 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL AV + ++ V+ LL + + + A T LH+AA + V A LV + V+
Sbjct: 110 PLHRAVASCSEEAVQVLL--KHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVN 167
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
++ AG+T LH AA G +VK AN D +DR +H AA GH +++LL
Sbjct: 168 VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLV- 226
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
A + + K T +H A+ +G L GV ++ PN Y
Sbjct: 227 SHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAY 271
Score = 71.7 bits (168), Expect = 3e-11
Identities = 49/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L A +G+ MV+ LLS + A A+H AA +++ ++LV +GA
Sbjct: 173 GRTALHHAAFSGHGEMVKLLLSR--GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA 230
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V + TPLH AA+ G +VKY + + + TP+H+A NG ++
Sbjct: 231 EVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNE 290
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGH-ADCAMMLFKKGVYLHMPNK 229
L D A + ++ + G T +H A+ + H A C +L G ++M +K
Sbjct: 291 LID-CGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSK 337
Score = 70.1 bits (164), Expect = 8e-11
Identities = 49/171 (28%), Positives = 80/171 (46%), Gaps = 4/171 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL A + + ++ ELL A+ + + G T LH+ A ++ ++
Sbjct: 303 EKGFTPLHFAAASTHGALCLELLVGNGAD-VNMKSKDGKTPLHMTALHGRFSRSQTIIQS 361
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA-AI 179
GAV+D + G TPLHIAA G E L+ A+ A P+HLAA +G +
Sbjct: 362 GAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCC 421
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
+LL+ F I G T +H A+ G+ +C +L G + +K+
Sbjct: 422 RKLLSSGF--DIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKF 470
Score = 67.7 bits (158), Expect = 4e-10
Identities = 43/132 (32%), Positives = 63/132 (47%), Gaps = 3/132 (2%)
Query: 102 LHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIAD 161
LHLAA +LV +D N +G+TPL +AA +G V A+ + D
Sbjct: 587 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 646
Query: 162 NE-DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGS--TLMHIASLNGHADCAMMLF 218
RTP+H AA NGH+ + LL + +DG+ T + ++ LNGH DC L
Sbjct: 647 YILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLL 706
Query: 219 KKGVYLHMPNKY 230
KG + +K+
Sbjct: 707 NKGANVDAKDKW 718
Score = 67.3 bits (157), Expect = 6e-10
Identities = 38/131 (29%), Positives = 65/131 (49%), Gaps = 2/131 (1%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T LH AA + + + L+D G ++ N G TPLH+A G + +V A
Sbjct: 241 TPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQ 300
Query: 160 ADNEDRTPMHLAAENGHAAI-IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF 218
+ + TP+H AA + H A+ +ELL A + ++KDG T +H+ +L+G + +
Sbjct: 301 KNEKGFTPLHFAAASTHGALCLELLVGN-GADVNMKSKDGKTPLHMTALHGRFSRSQTII 359
Query: 219 KKGVYLHMPNK 229
+ G + +K
Sbjct: 360 QSGAVIDCEDK 370
Score = 63.7 bits (148), Expect = 7e-09
Identities = 58/216 (26%), Positives = 101/216 (46%), Gaps = 16/216 (7%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL A G+ ++ ELL A ++ A T LH A + ++L+ + A
Sbjct: 75 RTPLHAAAYLGDAEII-ELLILSGA-RVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSAD 132
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
V+A + QTPLHIAAA + + +N ++D RT +H AA +GH +++LL
Sbjct: 133 VNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLL 192
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDEVLFVK 243
+ A+I K +H A+ GH + +L G + +K+++ L
Sbjct: 193 LSR-GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK----DKKSYTP-LHAA 246
Query: 244 IENGLIKGLKSDDGSYSMFLGIPYALVNESNPFGDS 279
+G+I +K Y + LG+ +NE N +G++
Sbjct: 247 ASSGMISVVK-----YLLDLGVD---MNEPNAYGNT 274
Score = 62.5 bits (145), Expect = 2e-08
Identities = 47/160 (29%), Positives = 76/160 (47%), Gaps = 7/160 (4%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G+ + L+ Q+ L +G T L LAA + V+ +L++ GA +
Sbjct: 586 PLHLAAYHGHHQALEVLV--QSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASIL 643
Query: 126 ATNGA-GQTPLHIAAAEGDEPLVKYFYGVRA--NAA-IADNEDRTPMHLAAENGHAAIIE 181
+ +TP+H AA G ++ G NA I D +TP+ L+ NGH +
Sbjct: 644 VKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVY 703
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L +K A++ + K G T +H ++ GH +C L + G
Sbjct: 704 SLLNK-GANVDAKDKWGRTALHRGAVTGHEECVDALLQHG 742
Score = 58.0 bits (134), Expect = 3e-07
Identities = 39/131 (29%), Positives = 61/131 (46%), Gaps = 3/131 (2%)
Query: 54 LIRDLVFQRGKVPLLLAVEAGNQSMVRELL-SAQTAEQLKATTPAGDTALHLAARRRDVD 112
L++D + +R P+ A G+ +R L+ +A+ + G T L L+ D
Sbjct: 643 LVKDYILKR--TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTD 700
Query: 113 MARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA 172
L++ GA VDA + G+T LH A G E V A + D+ RTP+HL+A
Sbjct: 701 CVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSA 760
Query: 173 ENGHAAIIELL 183
GH ++ L
Sbjct: 761 ACGHIGVLGAL 771
Score = 52.4 bits (120), Expect = 2e-05
Identities = 42/146 (28%), Positives = 68/146 (46%), Gaps = 3/146 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A G++ ++ L+++ A+ K G LHLAA D R L+
Sbjct: 370 KNGNTPLHIAARYGHELLINTLITSG-ADTAKRGIH-GMFPLHLAALSGFSDCCRKLLSS 427
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G +D + G+T LH AAA G+ + A+ D R+P+H AA N + +
Sbjct: 428 GFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCL 487
Query: 181 ELLADKFKASIFERTKDGSTLMHIAS 206
L AS+ + + G T +H A+
Sbjct: 488 FALVGS-GASVNDLDERGCTPLHYAA 512
Score = 52.0 bits (119), Expect = 2e-05
Identities = 30/116 (25%), Positives = 56/116 (48%)
Query: 102 LHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIAD 161
L L A +D+ + D+ N A +PLH+AA G ++ + + +
Sbjct: 554 LQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRN 613
Query: 162 NEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+ RTP+ LAA GH +++L ++ + + + T +H A+ NGH++C +L
Sbjct: 614 SSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLL 669
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/110 (31%), Positives = 53/110 (48%), Gaps = 5/110 (4%)
Query: 110 DVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTP 167
D D R L+ V+ + +TPLH AA GD +++ G R NA D++ TP
Sbjct: 53 DPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNA--KDSKWLTP 110
Query: 168 MHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+H A + +++L K A + R K+ T +HIA+ N CA L
Sbjct: 111 LHRAVASCSEEAVQVLL-KHSADVNARDKNWQTPLHIAAANKAVKCAEAL 159
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/102 (25%), Positives = 46/102 (45%), Gaps = 2/102 (1%)
Query: 1323 HGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAP 1382
+G V L+ + ++N D TPLH AA G +++LL SGA ++ + P
Sbjct: 51 NGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTP 110
Query: 1383 IWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKN 1424
+ A + + ++ LL +H DK + L + + N
Sbjct: 111 LHRAVASCSEEAVQVLL--KHSADVNARDKNWQTPLHIAAAN 150
Score = 35.9 bits (79), Expect = 1.6
Identities = 20/46 (43%), Positives = 24/46 (52%)
Query: 138 AAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
A GD V+ + + DNE RTP+H AA G A IIELL
Sbjct: 48 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELL 93
>AL592430-2|CAI40517.1| 1071|Homo sapiens ankyrin 3, node of Ranvier
(ankyrin G) protein.
Length = 1071
Score = 213 bits (519), Expect = 8e-54
Identities = 138/428 (32%), Positives = 216/428 (50%), Gaps = 26/428 (6%)
Query: 981 LLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASG 1040
LL KA N+KA NG T LH+A +++ L++ H A I +T TP+H+AA G
Sbjct: 1 LLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLK-HGASIQAVTESGLTPIHVAAFMG 59
Query: 1041 QIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCA 1100
+ + L+ GA+ + T+ G+ +H AA++ +EVV+ +L Q V A KD T
Sbjct: 60 HVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVR-YLVQDGAQVEAKAKDDQTPL 118
Query: 1101 HIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTD 1160
HI+A G ++++L++ G + TPL L+A GH DV L+ GAS +
Sbjct: 119 HISARLGKADIVQQLLQ---QGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSI 175
Query: 1161 ENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSH 1220
+ G T +H+AA++G V +++ + ++ K GLTPLH+AA+Y + LL
Sbjct: 176 TTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 235
Query: 1221 VPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGY 1280
G S P A++G TPLH+AA ++ LL G A+A + + G
Sbjct: 236 -----------GAS--PHAAAKNGYTPLHIAAKKNQMDIATTLLEY-GADANAVTRQ-GI 280
Query: 1281 NPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN 1340
+HLA GH+ +V LLL R+A + G T LH+A+ + EVL+ QGA ++
Sbjct: 281 ASVHLAAQEGHVDMVSLLLGRNANV------SGLTPLHLAAQEDRVNVAEVLVNQGAHVD 334
Query: 1341 ATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
A K G+TPLH G++ +V L + A ++T P+ AA + H ++ LL
Sbjct: 335 AQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 394
Query: 1401 KEHDTQSL 1408
L
Sbjct: 395 NNASPNEL 402
Score = 208 bits (508), Expect = 2e-52
Identities = 138/437 (31%), Positives = 223/437 (51%), Gaps = 26/437 (5%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G+TPL IAC + ++++ LL + A + G + +H+AA G++ + L+ + A
Sbjct: 15 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP 74
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N+ G TALH+AA +G A +V++L++D A ++ QTPLH++A G+ ++ + L
Sbjct: 75 NTTNVRGETALHMAARSGQAEVVRYLVQD-GAQVEAKAKDDQTPLHISARLGKADIVQQL 133
Query: 1049 LELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGS 1108
L+ GA+ +A G P+H +A+ + +V FL H + TTK G T H+AA G
Sbjct: 134 LQQGASPNAATTSGYTPLHLSAREGHEDVAA-FLLDHGASLSITTKKGFTPLHVAAKYGK 192
Query: 1109 VKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTA 1168
++V L++ + + ++ L TPL +AA + V +L+ GAS + G T
Sbjct: 193 LEVANLLLQKSASPDAAGKSGL---TPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTP 249
Query: 1169 VHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSE 1228
+H+AA+ ++ + + + G+ +H+AA G + V LL
Sbjct: 250 LHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV---- 305
Query: 1229 APTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACF 1288
SGLTPLHLAA NV +L+N G DA + + GY PLH+ C
Sbjct: 306 --------------SGLTPLHLAAQEDRVNVAEVLVNQ-GAHVDAQT-KMGYTPLHVGCH 349
Query: 1289 GGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWT 1348
G++ IV LL SA++ T ++G T LH A+ GH ++ VLL A N NG T
Sbjct: 350 YGNIKIVNFLLQHSAKVNAKT-KNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNT 408
Query: 1349 PLHCAAKAGHLNVVKLL 1365
L A + G+++VV L
Sbjct: 409 ALGIARRLGYISVVDTL 425
Score = 200 bits (487), Expect = 6e-50
Identities = 136/429 (31%), Positives = 225/429 (52%), Gaps = 26/429 (6%)
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY 1007
LL A + + G + LH+A + ++V + LL + A I + +G T +H+AA G+
Sbjct: 1 LLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGH 60
Query: 1008 AHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIH 1067
++V L+ H A + ++ +T LH+AA SGQ EV + L++ GA ++A + Q P+H
Sbjct: 61 VNIVSQLMH-HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLH 119
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
+A+ +++VQ LQQ + ATT G T H++A +G V L+ D +S
Sbjct: 120 ISARLGKADIVQQLLQQGASPNAATTS-GYTPLHLSAREGHEDVAAFLL--DHGASLSIT 176
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
K TPL +AA+ G +V +L++ AS ++GLT +H+AA + + V ++
Sbjct: 177 TK-KGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 235
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
++ K G TPLHIAA Q + LL + G V G+
Sbjct: 236 GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEY-----------GADANAV--TRQGIAS 282
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
+HLAA G+ ++V LLL +N +G PLHLA +++ +L+++ A +
Sbjct: 283 VHLAAQEGHVDMVSLLLGRN-------ANVSGLTPLHLAAQEDRVNVAEVLVNQGAHVDA 335
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
T + G T LH+ +G+ ++V LL A++NA KNG+TPLH AA+ GH +++ +L +
Sbjct: 336 QT-KMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 394
Query: 1368 SGASPKSET 1376
+ ASP T
Sbjct: 395 NNASPNELT 403
Score = 192 bits (468), Expect = 1e-47
Identities = 151/502 (30%), Positives = 247/502 (49%), Gaps = 47/502 (9%)
Query: 846 DGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDV 905
+G + LH ACK K +K V++ L+++GA + T T H A G+ ++
Sbjct: 14 NGFTPLHIACK--KNRIK-------VMELLLKHGASIQAVTESGL-TPIHVAAFMGHVNI 63
Query: 906 MTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSA 965
+++++ H ++ N N G T L +A G ++V L+ + A+V+ + ++
Sbjct: 64 VSQLMHHGASP------NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 117
Query: 966 LHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVL 1025
LH++A G + LL A N+ +G T LHL+A G+ + FL+ DH A + +
Sbjct: 118 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLL-DHGASLSIT 176
Query: 1026 TLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQH 1085
T K TPLH+AA G++EV LLL+ A+ DA + G P+H AA + +V L L Q
Sbjct: 177 TKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQG 236
Query: 1086 PNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA 1145
+ A K+G T HIAA + + + L+++ R + + LAA+ GH
Sbjct: 237 AS-PHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGI---ASVHLAAQEGHV 292
Query: 1146 DVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIA 1205
D+V +L+ A N +GLT +HLAA+ NV +V+ + + K+G TPLH+
Sbjct: 293 DMVSLLLGRNA-----NVSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVG 347
Query: 1206 AYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLN 1265
+YG + V LL H + K A T ++G TPLH AA G+ +++ +LL
Sbjct: 348 CHYGNIKIVNFLLQH---SAKVNAKT----------KNGYTPLHQAAQQGHTHIINVLL- 393
Query: 1266 SAGVQADAASNE---NGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIAST 1322
Q +A+ NE NG L +A G++S+V L + E + +T K +++ T
Sbjct: 394 ----QNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPET 449
Query: 1323 HGHYQMVEVLLGQGAEINATDK 1344
+ G+ A TDK
Sbjct: 450 MNEVLDMSDDEGEDAMTGDTDK 471
Score = 178 bits (434), Expect = 2e-43
Identities = 136/454 (29%), Positives = 224/454 (49%), Gaps = 44/454 (9%)
Query: 732 TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPL 791
TPLHIA + + K +LLK GA TE G+TP+HVAA G++ + L+ G P
Sbjct: 17 TPLHIACK-KNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPN 75
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
V GET L MA RS ++VR+L++ A ++A +D + L
Sbjct: 76 TTN-------VRGETALHMAARSGQAEVVRYLVQ----------DGAQVEAKAKDDQTPL 118
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIA 911
H + ++ K + +V+ L++ GA + T + T H A G+ DV ++
Sbjct: 119 HISARLGKAD---------IVQQLLQQGASPNAATTSGY-TPLHLSAREGHEDVAAFLLD 168
Query: 912 HISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAE 971
H +L+ G+TPL +A G +++ N LL A D G + LH+AA
Sbjct: 169 H------GASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAH 222
Query: 972 HGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQT 1031
+ +V LL A ++ A+NG T LH+AA + L+ ++ A + +T +
Sbjct: 223 YDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLL-EYGADANAVTRQGIA 281
Query: 1032 PLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
+HLAA G +++ LLL AN+ G P+H AAQ + V ++ + Q + V A
Sbjct: 282 SVHLAAQEGHVDMVSLLLGRNANVS-----GLTPLHLAAQEDRVNVAEVLVNQGAH-VDA 335
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
TK G T H+ G++K++ L++ + ++A+ K N TPL AA+ GH ++ VL
Sbjct: 336 QTKMGYTPLHVGCHYGNIKIVNFLLQ--HSAKVNAKTK-NGYTPLHQAAQQGHTHIINVL 392
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMR 1185
++ AS + G TA+ +A G+ +V+D ++
Sbjct: 393 LQNNASPNELTVNGNTALGIARRLGYISVVDTLK 426
Score = 167 bits (405), Expect = 5e-40
Identities = 132/468 (28%), Positives = 221/468 (47%), Gaps = 43/468 (9%)
Query: 750 LLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQ 809
LL A PN +G TP+H+A K + + LLL+ G T+ +G TP+
Sbjct: 1 LLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTE-------SGLTPIH 53
Query: 810 MACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADR 869
+A +IV L+ H G S +T + G +ALH A + +
Sbjct: 54 VAAFMGHVNIVSQLM-----HHGASPNTTNV-----RGETALHMAAR---------SGQA 94
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
+VV+ L+++GA V + + + +T H A G D++ +++ + N + G
Sbjct: 95 EVVRYLVQDGAQVEAKAK-DDQTPLHISARLGKADIVQQLLQQ------GASPNAATTSG 147
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
+TPL ++ GH + LL + A + + +G + LH+AA++G L+V + LL A +
Sbjct: 148 YTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPD 207
Query: 990 SKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL 1049
+ ++G T LH+AA + V L+ D A TPLH+AA Q+++ LL
Sbjct: 208 AAGKSGLTPLHVAA-HYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLL 266
Query: 1050 ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSV 1109
E GA+ +A G +H AAQ + ++V L L ++ N+ G T H+AA + V
Sbjct: 267 EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV------SGLTPLHLAAQEDRV 320
Query: 1110 KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAV 1169
V E L+ ++ + A+ K+ TPL + G+ +V L++ A + + G T +
Sbjct: 321 NVAEVLV--NQGAHVDAQTKMG-YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPL 377
Query: 1170 HLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVREL 1217
H AA+ GHT++++V+ N G T L IA G V L
Sbjct: 378 HQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 425
Score = 156 bits (379), Expect = 7e-37
Identities = 123/416 (29%), Positives = 196/416 (47%), Gaps = 41/416 (9%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G IH AA GHV I++ L+ G S + T TALH+A S + VV L+ GA V
Sbjct: 48 GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQV 107
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ K +TPLHI+AR+ D LL+ GA PN AT G TP+H++A+ G+
Sbjct: 108 EAK-AKDDQTPLHISARLGKAD-IVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAF 165
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL+ G TK G TPL +A + ++ L++ +A DA
Sbjct: 166 LLDHGASLSITTK-------KGFTPLHVAAKYGKLEVANLLLQ----------KSASPDA 208
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
+ G + LH A ++V + L++ GA ++ + T H A
Sbjct: 209 AGKSGLTPLHVAAHYDNQKVAL---------LLLDQGASPHAAAKNGY-TPLHIAAKKNQ 258
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
D+ T ++ + + A+ A+ RQ G + +A GH+ +V+ LL +A +V G
Sbjct: 259 MDIATTLLEYGADAN---AVTRQ---GIASVHLAAQEGHVDMVSLLLGRNA-----NVSG 307
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+ LHLAA+ + V + L+ A ++++ + G T LH+ G +V FL++ H+A +
Sbjct: 308 LTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQ-HSAKV 366
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVV 1078
+ T TPLH AA G + +LL+ A+ + G + A + Y VV
Sbjct: 367 NAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVV 422
Score = 155 bits (377), Expect = 1e-36
Identities = 134/470 (28%), Positives = 215/470 (45%), Gaps = 45/470 (9%)
Query: 682 LLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIP 741
LL K + + + +T LHIA + + V+E LL +GA + + TP+H+AA +
Sbjct: 1 LLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQ-AVTESGLTPIHVAAFMG 59
Query: 742 DGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDV 801
+ L+ GA PN G T +H+AA+ G + L++DG K K
Sbjct: 60 HVN-IVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAK------ 112
Query: 802 VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEE 861
+TPL ++ R DIV+ L++ +G S +A G + LH + + E+
Sbjct: 113 -DDQTPLHISARLGKADIVQQLLQ-----QGASP-----NAATTSGYTPLHLSAREGHED 161
Query: 862 VKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRA 921
V L+++GA +S+ T+ T H A G +V ++ ++ D +
Sbjct: 162 ---------VAAFLLDHGASLSITTKKGF-TPLHVAAKYGKLEVANLLLQKSASPDAA-- 209
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
G TPL +A H + ++ LL A G + LH+AA+ + + L
Sbjct: 210 ----GKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL 265
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
L A N+ R G ++HLAA G+ +V L+ NA + L TPLHLAA +
Sbjct: 266 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL-GRNANVSGL-----TPLHLAAQEDR 319
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAH 1101
+ V ++L+ GA++DA ++G P+H ++V FL QH V A TK+G T H
Sbjct: 320 VNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVN-FLLQHSAKVNAKTKNGYTPLH 378
Query: 1102 IAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
AA QG +I L+ + +N +T L +A G+ VV L
Sbjct: 379 QAAQQGHTHIINVLL---QNNASPNELTVNGNTALGIARRLGYISVVDTL 425
Score = 149 bits (362), Expect = 8e-35
Identities = 127/458 (27%), Positives = 209/458 (45%), Gaps = 44/458 (9%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K +G +H A + + ++ LL+ G S+ T T +H+A +V L+ +
Sbjct: 11 KALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHH 70
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
GA + + ET LH+AAR + L++ GA +D TP+H++A+ G
Sbjct: 71 GASPNTT-NVRGETALHMAARSGQAE-VVRYLVQDGAQVEAKAKDDQTPLHISARLGKAD 128
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LL+ G P T +G TPL ++ R D+ F+ DH G S+S
Sbjct: 129 IVQQLLQQGASPNAAT-------TSGYTPLHLSAREGHEDVA----AFLLDH-GASLS-- 174
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVS-LQTRHNHETAFHYC 897
+ G + LH A K K EV A+ + K + A S L H A HY
Sbjct: 175 ---ITTKKGFTPLHVAAKYGKLEV----ANLLLQKSASPDAAGKSGLTPLH---VAAHY- 223
Query: 898 AIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
+N + ++ + + A N G+TPL IA + M + TLL A +
Sbjct: 224 ----DNQKVALLLLDQGASPHAAAKN-----GYTPLHIAAKKNQMDIATTLLEYGADANA 274
Query: 958 FDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRD 1017
+G +++HLAA+ G++ + LL A + +G T LHLAA ++ + L+ +
Sbjct: 275 VTRQGIASVHLAAQEGHVDMVSLLLGRNANV-----SGLTPLHLAAQEDRVNVAEVLV-N 328
Query: 1018 HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEV 1077
A +D T TPLH+ G I++ LL+ A ++A + G P+H AAQ ++ +
Sbjct: 329 QGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHI 388
Query: 1078 VQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEEL 1115
+ + LQ + + T +GNT IA G + V++ L
Sbjct: 389 INVLLQNNAS-PNELTVNGNTALGIARRLGYISVVDTL 425
Score = 117 bits (282), Expect = 4e-25
Identities = 71/211 (33%), Positives = 112/211 (53%), Gaps = 8/211 (3%)
Query: 1237 PVLGAESGLTPLHLAAYNGNENVVRLLL-NSAGVQADAASNENGYNPLHLACFGGHMSIV 1295
P A +G TPLH+A V+ LLL + A +QA E+G P+H+A F GH++IV
Sbjct: 8 PNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA---VTESGLTPIHVAAFMGHVNIV 64
Query: 1296 GLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAK 1355
L+ A ++T+ G+T LH+A+ G ++V L+ GA++ A K+ TPLH +A+
Sbjct: 65 SQLMHHGASP-NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISAR 123
Query: 1356 AGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFV 1415
G ++V+ L + GASP + T P+ +A E H DV +LL +H + K+
Sbjct: 124 LGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLL--DHGASLSITTKKGF 181
Query: 1416 YNLMVCSKNHNNIPIEEFVLVSPAPVDTAAK 1446
L V +K + + + +L A D A K
Sbjct: 182 TPLHVAAK-YGKLEVANLLLQKSASPDAAGK 211
Score = 87.0 bits (206), Expect = 6e-16
Identities = 55/162 (33%), Positives = 83/162 (51%), Gaps = 3/162 (1%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V + G P+ +A G+ ++V +L+ + T G+TALH+AAR ++ R LV
Sbjct: 44 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPN--TTNVRGETALHMAARSGQAEVVRYLV 101
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
GA V+A QTPLHI+A G +V+ A+ A TP+HL+A GH
Sbjct: 102 QDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHED 161
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+ L D AS+ TK G T +H+A+ G + A +L +K
Sbjct: 162 VAAFLLD-HGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK 202
Score = 85.8 bits (203), Expect = 1e-15
Identities = 56/167 (33%), Positives = 86/167 (51%), Gaps = 3/167 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL +A + N+ V ELL A ++A T +G T +H+AA V++ L+ +GA
Sbjct: 15 GFTPLHIACKK-NRIKVMELLLKHGAS-IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGA 72
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ TN G+T LH+AA G +V+Y A +D+TP+H++A G A I++
Sbjct: 73 SPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQ 132
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L + AS T G T +H+++ GH D A L G L + K
Sbjct: 133 LLQQ-GASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTK 178
Score = 81.8 bits (193), Expect = 2e-14
Identities = 53/158 (33%), Positives = 77/158 (48%), Gaps = 3/158 (1%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL ++ G +V++LL Q A T +G T LHL+AR D+A L+D+GA
Sbjct: 115 QTPLHISARLGKADIVQQLL--QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGAS 172
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
+ T G TPLH+AA G + A+ A TP+H+AA + + LL
Sbjct: 173 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 232
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
D+ AS K+G T +HIA+ D A L + G
Sbjct: 233 LDQ-GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYG 269
Score = 74.1 bits (174), Expect = 5e-12
Identities = 52/152 (34%), Positives = 75/152 (49%), Gaps = 8/152 (5%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++G + LA + G+ MV LL + +G T LHLAA+ V++A +LV
Sbjct: 275 VTRQGIASVHLAAQEGHVDMVSLLLG-------RNANVSGLTPLHLAAQEDRVNVAEVLV 327
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
+ GA VDA G TPLH+ G+ +V + A TP+H AA+ GH
Sbjct: 328 NQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTH 387
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGH 210
II +L AS E T +G+T + IA G+
Sbjct: 388 IINVLLQN-NASPNELTVNGNTALGIARRLGY 418
Score = 65.3 bits (152), Expect = 2e-09
Identities = 48/169 (28%), Positives = 79/169 (46%), Gaps = 8/169 (4%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL +A + G + LL Q + A +G T LH+AA + +A +L+D
Sbjct: 178 KKGFTPLHVAAKYGKLEVANLLL--QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 235
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA A G TPLHIAA + + A+A + +HLAA+ GH ++
Sbjct: 236 GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMV 295
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
LL + A++ G T +H+A+ + A +L +G ++ K
Sbjct: 296 SLLLGR-NANV-----SGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTK 338
Score = 62.5 bits (145), Expect = 2e-08
Identities = 44/159 (27%), Positives = 71/159 (44%), Gaps = 8/159 (5%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A + + LL + A T G ++HLAA+ VDM +L+
Sbjct: 244 KNGYTPLHIAAKKNQMDIATTLL--EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGR 301
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A N +G TPLH+AA E + + A+ TP+H+ G+ I+
Sbjct: 302 NA-----NVSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIV 356
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
L + A + +TK+G T +H A+ GH +L +
Sbjct: 357 NFLL-QHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 394
Score = 46.4 bits (105), Expect = 0.001
Identities = 33/121 (27%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL LA + + V E+L Q A + A T G T LH+ ++ + L+ + A
Sbjct: 307 GLTPLHLAAQEDRVN-VAEVLVNQGAH-VDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSA 364
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+A G TPLH AA +G ++ A+ T + +A G+ ++++
Sbjct: 365 KVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDT 424
Query: 183 L 183
L
Sbjct: 425 L 425
Score = 41.5 bits (93), Expect = 0.031
Identities = 32/113 (28%), Positives = 49/113 (43%), Gaps = 1/113 (0%)
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+D A +A G TPLHIA + +++ A+ TP+H+AA GH
Sbjct: 1 LLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGH 60
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
I+ L AS G T +H+A+ +G A+ L + G + K
Sbjct: 61 VNIVSQLM-HHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAK 112
>AL359377-1|CAI41372.1| 1071|Homo sapiens ankyrin 3, node of Ranvier
(ankyrin G) protein.
Length = 1071
Score = 213 bits (519), Expect = 8e-54
Identities = 138/428 (32%), Positives = 216/428 (50%), Gaps = 26/428 (6%)
Query: 981 LLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASG 1040
LL KA N+KA NG T LH+A +++ L++ H A I +T TP+H+AA G
Sbjct: 1 LLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLK-HGASIQAVTESGLTPIHVAAFMG 59
Query: 1041 QIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCA 1100
+ + L+ GA+ + T+ G+ +H AA++ +EVV+ +L Q V A KD T
Sbjct: 60 HVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVR-YLVQDGAQVEAKAKDDQTPL 118
Query: 1101 HIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTD 1160
HI+A G ++++L++ G + TPL L+A GH DV L+ GAS +
Sbjct: 119 HISARLGKADIVQQLLQ---QGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSI 175
Query: 1161 ENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSH 1220
+ G T +H+AA++G V +++ + ++ K GLTPLH+AA+Y + LL
Sbjct: 176 TTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 235
Query: 1221 VPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGY 1280
G S P A++G TPLH+AA ++ LL G A+A + + G
Sbjct: 236 -----------GAS--PHAAAKNGYTPLHIAAKKNQMDIATTLLEY-GADANAVTRQ-GI 280
Query: 1281 NPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN 1340
+HLA GH+ +V LLL R+A + G T LH+A+ + EVL+ QGA ++
Sbjct: 281 ASVHLAAQEGHVDMVSLLLGRNANV------SGLTPLHLAAQEDRVNVAEVLVNQGAHVD 334
Query: 1341 ATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
A K G+TPLH G++ +V L + A ++T P+ AA + H ++ LL
Sbjct: 335 AQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 394
Query: 1401 KEHDTQSL 1408
L
Sbjct: 395 NNASPNEL 402
Score = 208 bits (508), Expect = 2e-52
Identities = 138/437 (31%), Positives = 223/437 (51%), Gaps = 26/437 (5%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G+TPL IAC + ++++ LL + A + G + +H+AA G++ + L+ + A
Sbjct: 15 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP 74
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N+ G TALH+AA +G A +V++L++D A ++ QTPLH++A G+ ++ + L
Sbjct: 75 NTTNVRGETALHMAARSGQAEVVRYLVQD-GAQVEAKAKDDQTPLHISARLGKADIVQQL 133
Query: 1049 LELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGS 1108
L+ GA+ +A G P+H +A+ + +V FL H + TTK G T H+AA G
Sbjct: 134 LQQGASPNAATTSGYTPLHLSAREGHEDVAA-FLLDHGASLSITTKKGFTPLHVAAKYGK 192
Query: 1109 VKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTA 1168
++V L++ + + ++ L TPL +AA + V +L+ GAS + G T
Sbjct: 193 LEVANLLLQKSASPDAAGKSGL---TPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTP 249
Query: 1169 VHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSE 1228
+H+AA+ ++ + + + G+ +H+AA G + V LL
Sbjct: 250 LHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV---- 305
Query: 1229 APTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACF 1288
SGLTPLHLAA NV +L+N G DA + + GY PLH+ C
Sbjct: 306 --------------SGLTPLHLAAQEDRVNVAEVLVNQ-GAHVDAQT-KMGYTPLHVGCH 349
Query: 1289 GGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWT 1348
G++ IV LL SA++ T ++G T LH A+ GH ++ VLL A N NG T
Sbjct: 350 YGNIKIVNFLLQHSAKVNAKT-KNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNT 408
Query: 1349 PLHCAAKAGHLNVVKLL 1365
L A + G+++VV L
Sbjct: 409 ALGIARRLGYISVVDTL 425
Score = 200 bits (487), Expect = 6e-50
Identities = 136/429 (31%), Positives = 225/429 (52%), Gaps = 26/429 (6%)
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY 1007
LL A + + G + LH+A + ++V + LL + A I + +G T +H+AA G+
Sbjct: 1 LLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGH 60
Query: 1008 AHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIH 1067
++V L+ H A + ++ +T LH+AA SGQ EV + L++ GA ++A + Q P+H
Sbjct: 61 VNIVSQLMH-HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLH 119
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
+A+ +++VQ LQQ + ATT G T H++A +G V L+ D +S
Sbjct: 120 ISARLGKADIVQQLLQQGASPNAATTS-GYTPLHLSAREGHEDVAAFLL--DHGASLSIT 176
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
K TPL +AA+ G +V +L++ AS ++GLT +H+AA + + V ++
Sbjct: 177 TK-KGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 235
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
++ K G TPLHIAA Q + LL + G V G+
Sbjct: 236 GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEY-----------GADANAV--TRQGIAS 282
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
+HLAA G+ ++V LLL +N +G PLHLA +++ +L+++ A +
Sbjct: 283 VHLAAQEGHVDMVSLLLGRN-------ANVSGLTPLHLAAQEDRVNVAEVLVNQGAHVDA 335
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
T + G T LH+ +G+ ++V LL A++NA KNG+TPLH AA+ GH +++ +L +
Sbjct: 336 QT-KMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 394
Query: 1368 SGASPKSET 1376
+ ASP T
Sbjct: 395 NNASPNELT 403
Score = 192 bits (468), Expect = 1e-47
Identities = 151/502 (30%), Positives = 247/502 (49%), Gaps = 47/502 (9%)
Query: 846 DGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDV 905
+G + LH ACK K +K V++ L+++GA + T T H A G+ ++
Sbjct: 14 NGFTPLHIACK--KNRIK-------VMELLLKHGASIQAVTESGL-TPIHVAAFMGHVNI 63
Query: 906 MTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSA 965
+++++ H ++ N N G T L +A G ++V L+ + A+V+ + ++
Sbjct: 64 VSQLMHHGASP------NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 117
Query: 966 LHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVL 1025
LH++A G + LL A N+ +G T LHL+A G+ + FL+ DH A + +
Sbjct: 118 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLL-DHGASLSIT 176
Query: 1026 TLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQH 1085
T K TPLH+AA G++EV LLL+ A+ DA + G P+H AA + +V L L Q
Sbjct: 177 TKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQG 236
Query: 1086 PNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA 1145
+ A K+G T HIAA + + + L+++ R + + LAA+ GH
Sbjct: 237 AS-PHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGI---ASVHLAAQEGHV 292
Query: 1146 DVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIA 1205
D+V +L+ A N +GLT +HLAA+ NV +V+ + + K+G TPLH+
Sbjct: 293 DMVSLLLGRNA-----NVSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVG 347
Query: 1206 AYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLN 1265
+YG + V LL H + K A T ++G TPLH AA G+ +++ +LL
Sbjct: 348 CHYGNIKIVNFLLQH---SAKVNAKT----------KNGYTPLHQAAQQGHTHIINVLL- 393
Query: 1266 SAGVQADAASNE---NGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIAST 1322
Q +A+ NE NG L +A G++S+V L + E + +T K +++ T
Sbjct: 394 ----QNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPET 449
Query: 1323 HGHYQMVEVLLGQGAEINATDK 1344
+ G+ A TDK
Sbjct: 450 MNEVLDMSDDEGEDAMTGDTDK 471
Score = 178 bits (434), Expect = 2e-43
Identities = 136/454 (29%), Positives = 224/454 (49%), Gaps = 44/454 (9%)
Query: 732 TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPL 791
TPLHIA + + K +LLK GA TE G+TP+HVAA G++ + L+ G P
Sbjct: 17 TPLHIACK-KNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPN 75
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
V GET L MA RS ++VR+L++ A ++A +D + L
Sbjct: 76 TTN-------VRGETALHMAARSGQAEVVRYLVQ----------DGAQVEAKAKDDQTPL 118
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIA 911
H + ++ K + +V+ L++ GA + T + T H A G+ DV ++
Sbjct: 119 HISARLGKAD---------IVQQLLQQGASPNAATTSGY-TPLHLSAREGHEDVAAFLLD 168
Query: 912 HISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAE 971
H +L+ G+TPL +A G +++ N LL A D G + LH+AA
Sbjct: 169 H------GASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAH 222
Query: 972 HGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQT 1031
+ +V LL A ++ A+NG T LH+AA + L+ ++ A + +T +
Sbjct: 223 YDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLL-EYGADANAVTRQGIA 281
Query: 1032 PLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
+HLAA G +++ LLL AN+ G P+H AAQ + V ++ + Q + V A
Sbjct: 282 SVHLAAQEGHVDMVSLLLGRNANVS-----GLTPLHLAAQEDRVNVAEVLVNQGAH-VDA 335
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
TK G T H+ G++K++ L++ + ++A+ K N TPL AA+ GH ++ VL
Sbjct: 336 QTKMGYTPLHVGCHYGNIKIVNFLLQ--HSAKVNAKTK-NGYTPLHQAAQQGHTHIINVL 392
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMR 1185
++ AS + G TA+ +A G+ +V+D ++
Sbjct: 393 LQNNASPNELTVNGNTALGIARRLGYISVVDTLK 426
Score = 167 bits (405), Expect = 5e-40
Identities = 132/468 (28%), Positives = 221/468 (47%), Gaps = 43/468 (9%)
Query: 750 LLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQ 809
LL A PN +G TP+H+A K + + LLL+ G T+ +G TP+
Sbjct: 1 LLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTE-------SGLTPIH 53
Query: 810 MACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADR 869
+A +IV L+ H G S +T + G +ALH A + +
Sbjct: 54 VAAFMGHVNIVSQLM-----HHGASPNTTNV-----RGETALHMAAR---------SGQA 94
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
+VV+ L+++GA V + + + +T H A G D++ +++ + N + G
Sbjct: 95 EVVRYLVQDGAQVEAKAK-DDQTPLHISARLGKADIVQQLLQQ------GASPNAATTSG 147
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
+TPL ++ GH + LL + A + + +G + LH+AA++G L+V + LL A +
Sbjct: 148 YTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPD 207
Query: 990 SKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL 1049
+ ++G T LH+AA + V L+ D A TPLH+AA Q+++ LL
Sbjct: 208 AAGKSGLTPLHVAA-HYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLL 266
Query: 1050 ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSV 1109
E GA+ +A G +H AAQ + ++V L L ++ N+ G T H+AA + V
Sbjct: 267 EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV------SGLTPLHLAAQEDRV 320
Query: 1110 KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAV 1169
V E L+ ++ + A+ K+ TPL + G+ +V L++ A + + G T +
Sbjct: 321 NVAEVLV--NQGAHVDAQTKMG-YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPL 377
Query: 1170 HLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVREL 1217
H AA+ GHT++++V+ N G T L IA G V L
Sbjct: 378 HQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 425
Score = 156 bits (379), Expect = 7e-37
Identities = 123/416 (29%), Positives = 196/416 (47%), Gaps = 41/416 (9%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G IH AA GHV I++ L+ G S + T TALH+A S + VV L+ GA V
Sbjct: 48 GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQV 107
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ K +TPLHI+AR+ D LL+ GA PN AT G TP+H++A+ G+
Sbjct: 108 EAK-AKDDQTPLHISARLGKAD-IVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAF 165
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL+ G TK G TPL +A + ++ L++ +A DA
Sbjct: 166 LLDHGASLSITTK-------KGFTPLHVAAKYGKLEVANLLLQ----------KSASPDA 208
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
+ G + LH A ++V + L++ GA ++ + T H A
Sbjct: 209 AGKSGLTPLHVAAHYDNQKVAL---------LLLDQGASPHAAAKNGY-TPLHIAAKKNQ 258
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
D+ T ++ + + A+ A+ RQ G + +A GH+ +V+ LL +A +V G
Sbjct: 259 MDIATTLLEYGADAN---AVTRQ---GIASVHLAAQEGHVDMVSLLLGRNA-----NVSG 307
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+ LHLAA+ + V + L+ A ++++ + G T LH+ G +V FL++ H+A +
Sbjct: 308 LTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQ-HSAKV 366
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVV 1078
+ T TPLH AA G + +LL+ A+ + G + A + Y VV
Sbjct: 367 NAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVV 422
Score = 155 bits (377), Expect = 1e-36
Identities = 134/470 (28%), Positives = 215/470 (45%), Gaps = 45/470 (9%)
Query: 682 LLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIP 741
LL K + + + +T LHIA + + V+E LL +GA + + TP+H+AA +
Sbjct: 1 LLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQ-AVTESGLTPIHVAAFMG 59
Query: 742 DGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDV 801
+ L+ GA PN G T +H+AA+ G + L++DG K K
Sbjct: 60 HVN-IVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAK------ 112
Query: 802 VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEE 861
+TPL ++ R DIV+ L++ +G S +A G + LH + + E+
Sbjct: 113 -DDQTPLHISARLGKADIVQQLLQ-----QGASP-----NAATTSGYTPLHLSAREGHED 161
Query: 862 VKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRA 921
V L+++GA +S+ T+ T H A G +V ++ ++ D +
Sbjct: 162 ---------VAAFLLDHGASLSITTKKGF-TPLHVAAKYGKLEVANLLLQKSASPDAA-- 209
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
G TPL +A H + ++ LL A G + LH+AA+ + + L
Sbjct: 210 ----GKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL 265
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
L A N+ R G ++HLAA G+ +V L+ NA + L TPLHLAA +
Sbjct: 266 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL-GRNANVSGL-----TPLHLAAQEDR 319
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAH 1101
+ V ++L+ GA++DA ++G P+H ++V FL QH V A TK+G T H
Sbjct: 320 VNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVN-FLLQHSAKVNAKTKNGYTPLH 378
Query: 1102 IAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
AA QG +I L+ + +N +T L +A G+ VV L
Sbjct: 379 QAAQQGHTHIINVLL---QNNASPNELTVNGNTALGIARRLGYISVVDTL 425
Score = 149 bits (362), Expect = 8e-35
Identities = 127/458 (27%), Positives = 209/458 (45%), Gaps = 44/458 (9%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K +G +H A + + ++ LL+ G S+ T T +H+A +V L+ +
Sbjct: 11 KALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHH 70
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
GA + + ET LH+AAR + L++ GA +D TP+H++A+ G
Sbjct: 71 GASPNTT-NVRGETALHMAARSGQAE-VVRYLVQDGAQVEAKAKDDQTPLHISARLGKAD 128
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LL+ G P T +G TPL ++ R D+ F+ DH G S+S
Sbjct: 129 IVQQLLQQGASPNAAT-------TSGYTPLHLSAREGHEDVA----AFLLDH-GASLS-- 174
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVS-LQTRHNHETAFHYC 897
+ G + LH A K K EV A+ + K + A S L H A HY
Sbjct: 175 ---ITTKKGFTPLHVAAKYGKLEV----ANLLLQKSASPDAAGKSGLTPLH---VAAHY- 223
Query: 898 AIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
+N + ++ + + A N G+TPL IA + M + TLL A +
Sbjct: 224 ----DNQKVALLLLDQGASPHAAAKN-----GYTPLHIAAKKNQMDIATTLLEYGADANA 274
Query: 958 FDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRD 1017
+G +++HLAA+ G++ + LL A + +G T LHLAA ++ + L+ +
Sbjct: 275 VTRQGIASVHLAAQEGHVDMVSLLLGRNANV-----SGLTPLHLAAQEDRVNVAEVLV-N 328
Query: 1018 HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEV 1077
A +D T TPLH+ G I++ LL+ A ++A + G P+H AAQ ++ +
Sbjct: 329 QGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHI 388
Query: 1078 VQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEEL 1115
+ + LQ + + T +GNT IA G + V++ L
Sbjct: 389 INVLLQNNAS-PNELTVNGNTALGIARRLGYISVVDTL 425
Score = 117 bits (282), Expect = 4e-25
Identities = 71/211 (33%), Positives = 112/211 (53%), Gaps = 8/211 (3%)
Query: 1237 PVLGAESGLTPLHLAAYNGNENVVRLLL-NSAGVQADAASNENGYNPLHLACFGGHMSIV 1295
P A +G TPLH+A V+ LLL + A +QA E+G P+H+A F GH++IV
Sbjct: 8 PNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA---VTESGLTPIHVAAFMGHVNIV 64
Query: 1296 GLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAK 1355
L+ A ++T+ G+T LH+A+ G ++V L+ GA++ A K+ TPLH +A+
Sbjct: 65 SQLMHHGASP-NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISAR 123
Query: 1356 AGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFV 1415
G ++V+ L + GASP + T P+ +A E H DV +LL +H + K+
Sbjct: 124 LGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLL--DHGASLSITTKKGF 181
Query: 1416 YNLMVCSKNHNNIPIEEFVLVSPAPVDTAAK 1446
L V +K + + + +L A D A K
Sbjct: 182 TPLHVAAK-YGKLEVANLLLQKSASPDAAGK 211
Score = 87.0 bits (206), Expect = 6e-16
Identities = 55/162 (33%), Positives = 83/162 (51%), Gaps = 3/162 (1%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V + G P+ +A G+ ++V +L+ + T G+TALH+AAR ++ R LV
Sbjct: 44 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPN--TTNVRGETALHMAARSGQAEVVRYLV 101
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
GA V+A QTPLHI+A G +V+ A+ A TP+HL+A GH
Sbjct: 102 QDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHED 161
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+ L D AS+ TK G T +H+A+ G + A +L +K
Sbjct: 162 VAAFLLD-HGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK 202
Score = 85.8 bits (203), Expect = 1e-15
Identities = 56/167 (33%), Positives = 86/167 (51%), Gaps = 3/167 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL +A + N+ V ELL A ++A T +G T +H+AA V++ L+ +GA
Sbjct: 15 GFTPLHIACKK-NRIKVMELLLKHGAS-IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGA 72
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ TN G+T LH+AA G +V+Y A +D+TP+H++A G A I++
Sbjct: 73 SPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQ 132
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L + AS T G T +H+++ GH D A L G L + K
Sbjct: 133 LLQQ-GASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTK 178
Score = 81.8 bits (193), Expect = 2e-14
Identities = 53/158 (33%), Positives = 77/158 (48%), Gaps = 3/158 (1%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL ++ G +V++LL Q A T +G T LHL+AR D+A L+D+GA
Sbjct: 115 QTPLHISARLGKADIVQQLL--QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGAS 172
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
+ T G TPLH+AA G + A+ A TP+H+AA + + LL
Sbjct: 173 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 232
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
D+ AS K+G T +HIA+ D A L + G
Sbjct: 233 LDQ-GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYG 269
Score = 74.1 bits (174), Expect = 5e-12
Identities = 52/152 (34%), Positives = 75/152 (49%), Gaps = 8/152 (5%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++G + LA + G+ MV LL + +G T LHLAA+ V++A +LV
Sbjct: 275 VTRQGIASVHLAAQEGHVDMVSLLLG-------RNANVSGLTPLHLAAQEDRVNVAEVLV 327
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
+ GA VDA G TPLH+ G+ +V + A TP+H AA+ GH
Sbjct: 328 NQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTH 387
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGH 210
II +L AS E T +G+T + IA G+
Sbjct: 388 IINVLLQN-NASPNELTVNGNTALGIARRLGY 418
Score = 65.3 bits (152), Expect = 2e-09
Identities = 48/169 (28%), Positives = 79/169 (46%), Gaps = 8/169 (4%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL +A + G + LL Q + A +G T LH+AA + +A +L+D
Sbjct: 178 KKGFTPLHVAAKYGKLEVANLLL--QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 235
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA A G TPLHIAA + + A+A + +HLAA+ GH ++
Sbjct: 236 GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMV 295
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
LL + A++ G T +H+A+ + A +L +G ++ K
Sbjct: 296 SLLLGR-NANV-----SGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTK 338
Score = 62.5 bits (145), Expect = 2e-08
Identities = 44/159 (27%), Positives = 71/159 (44%), Gaps = 8/159 (5%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A + + LL + A T G ++HLAA+ VDM +L+
Sbjct: 244 KNGYTPLHIAAKKNQMDIATTLL--EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGR 301
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A N +G TPLH+AA E + + A+ TP+H+ G+ I+
Sbjct: 302 NA-----NVSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIV 356
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
L + A + +TK+G T +H A+ GH +L +
Sbjct: 357 NFLL-QHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 394
Score = 46.4 bits (105), Expect = 0.001
Identities = 33/121 (27%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL LA + + V E+L Q A + A T G T LH+ ++ + L+ + A
Sbjct: 307 GLTPLHLAAQEDRVN-VAEVLVNQGAH-VDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSA 364
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+A G TPLH AA +G ++ A+ T + +A G+ ++++
Sbjct: 365 KVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDT 424
Query: 183 L 183
L
Sbjct: 425 L 425
Score = 41.5 bits (93), Expect = 0.031
Identities = 32/113 (28%), Positives = 49/113 (43%), Gaps = 1/113 (0%)
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+D A +A G TPLHIA + +++ A+ TP+H+AA GH
Sbjct: 1 LLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGH 60
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
I+ L AS G T +H+A+ +G A+ L + G + K
Sbjct: 61 VNIVSQLM-HHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAK 112
>BX640674-1|CAE45806.1| 1280|Homo sapiens hypothetical protein
protein.
Length = 1280
Score = 211 bits (516), Expect = 2e-53
Identities = 169/535 (31%), Positives = 268/535 (50%), Gaps = 35/535 (6%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
+VV CLI GA+++ T + TA A G+ +V++ ++ D + A +R
Sbjct: 443 KVVNCLIGCGANIN-HTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSR----- 496
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
T L A GH +V LL + A V+ D EGR+AL AA G+ ++ + LL + A +N
Sbjct: 497 -TALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVN 555
Query: 990 SKARNGRTALHLAAM-----NGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEV 1044
+ +GRTAL +AA+ G+A +V LI D A +D TPL +AA G ++V
Sbjct: 556 HEDVDGRTALSVAALCVPASKGHASVVSLLI-DRGAEVDHCDKDGMTPLLVAAYEGHVDV 614
Query: 1045 CKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
LLLE GA++D TD G+ P+ AAA ++ VV L V + +G T IA+
Sbjct: 615 VDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGA-AVDSIDSEGRTVLSIAS 673
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
QG+V+V+ L+ DR G+ TPL +AA GH + L+ GA + +
Sbjct: 674 AQGNVEVVRTLL--DR-GLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDND 730
Query: 1165 GLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKL-GLTPLHIAAYYGQAETVRELLSHVPG 1223
G LA++ GH + + ++ N I + G L +AA G + V L SH
Sbjct: 731 GRIPFILASQEGHYDCVQILLE-NKSNIDQRGYDGRNALRVAALEGHRDIVELLFSH-GA 788
Query: 1224 TVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPL 1283
V + G + +L E+ LT +A Y L N A V+A S+ G L
Sbjct: 789 DVNCKDADGRPTLYILALENQLT---MAEY--------FLENGANVEA---SDAEGRTAL 834
Query: 1284 HLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATD 1343
H++C+ GHM +V +L++ A++ ++ D ++ L A+ GH ++V++L+ GA ++ T
Sbjct: 835 HVSCWQGHMEMVQVLIAYHADV-NAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTC 893
Query: 1344 KNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G T L AA+ GH++VV++L E GA P + AA H+ +++ L
Sbjct: 894 NQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL 948
Score = 200 bits (488), Expect = 4e-50
Identities = 167/564 (29%), Positives = 261/564 (46%), Gaps = 36/564 (6%)
Query: 871 VVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGW 930
VV L+ GAD+ ++ H H T A G+ V+ +I +N + GW
Sbjct: 411 VVNLLVSRGADLEIEDAHGH-TPLTLAARQGHTKVVNCLIG------CGANINHTDQDGW 463
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
T L A GH ++V+ LL +VD D + R+AL AA G+ + LL + A +N
Sbjct: 464 TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK 523
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAA-----ASGQIEVC 1045
GRTAL AA G+ +V+ L+ DH A ++ + +T L +AA + G V
Sbjct: 524 ADNEGRTALIAAAYMGHREIVEHLL-DHGAEVNHEDVDGRTALSVAALCVPASKGHASVV 582
Query: 1046 KLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAI 1105
LL++ GA +D D+ G P+ AA + +VV L L+ + V T +G T AA
Sbjct: 583 SLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGAD-VDHTDNNGRTPLLAAAS 641
Query: 1106 QGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAG 1165
G V+ L+ F V S ++ T L +A+ G+ +VVR L+ G + AG
Sbjct: 642 MGHASVVNTLL-FWGAAVDSIDSE--GRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAG 698
Query: 1166 LTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTV 1225
T +H+AA GH + + + G P +A+ G + V+ LL +
Sbjct: 699 WTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLEN----- 753
Query: 1226 KSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHL 1285
KS + G + G L +AA G+ ++V LL S G + + +G L++
Sbjct: 754 KSN-------IDQRGYD-GRNALRVAALEGHRDIVELLF-SHGADVNC-KDADGRPTLYI 803
Query: 1286 ACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKN 1345
+++ L A + ++D G+T LH++ GH +MV+VL+ A++NA D
Sbjct: 804 LALENQLTMAEYFLENGANV-EASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNE 862
Query: 1346 GWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
+ L AA GH+ VV+LL E GA N + AA E H DV++ LL EH
Sbjct: 863 KRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLL--EHGA 920
Query: 1406 QSLMDDKRFVYNLMVCSKN-HNNI 1428
D+ + V +KN H+ I
Sbjct: 921 DPNHADQFGRTAMRVAAKNGHSQI 944
Score = 175 bits (427), Expect = 1e-42
Identities = 161/573 (28%), Positives = 266/573 (46%), Gaps = 39/573 (6%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G + AAR GH ++N L+ G +++ T D +TAL A VV LL G V
Sbjct: 429 GHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKV 488
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
R T L AA D L LL+ GA NKA +G T + AA G+ +
Sbjct: 489 DCADADSR-TALRAAAWGGHED-IVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEH 546
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH--LIEFVKDHKGESVSTAFI 840
LL+ G + ++ V G T L +A C+P H ++ + D E +
Sbjct: 547 LLDHGAE-------VNHEDVDGRTALSVAAL-CVPASKGHASVVSLLIDRGAE------V 592
Query: 841 DAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIA 900
D D+DG + L V E + VV L+E GADV T +N T A
Sbjct: 593 DHCDKDGMTPL----LVAAYEGHV-----DVVDLLLEGGADVD-HTDNNGRTPLLAAASM 642
Query: 901 GNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDV 960
G+ V+ ++ A++ +S G T L IA +G++++V TLL + D
Sbjct: 643 GHASVVNTLLFW------GAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDD 696
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
G + LH+AA G+ +C+AL+ A N +GR LA+ G+ V+ L+ ++ +
Sbjct: 697 AGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILL-ENKS 755
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQL 1080
ID + L +AA G ++ +LL GA+++ D G+ ++ A N + +
Sbjct: 756 NIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEY 815
Query: 1081 FLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAA 1140
FL+ N V A+ +G T H++ QG +++++ L+ + V +A N+ + LQ AA
Sbjct: 816 FLENGAN-VEASDAEGRTALHVSCWQGHMEMVQVLIAY-HADVNAADNEKRSA--LQSAA 871
Query: 1141 EGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLT 1200
GH VV++L+ GA G TA+ +AA+ GH +V+ V+ + + G T
Sbjct: 872 WQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRT 931
Query: 1201 PLHIAAYYGQAETVRELLSHVPGTVKSEAPTGV 1233
+ +AA G ++ ++ L + ++ +P+ V
Sbjct: 932 AMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPV 964
Score = 161 bits (390), Expect = 3e-38
Identities = 175/633 (27%), Positives = 276/633 (43%), Gaps = 58/633 (9%)
Query: 679 INTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAA 738
I TLL G SV+ ++ T L A S VV L+ GAD+ I TPL +AA
Sbjct: 379 IRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDA-HGHTPLTLAA 437
Query: 739 RIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCI 798
R K L+ GA N +DG T + AA G+ + LL G KV
Sbjct: 438 R-QGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAG------VKVDC 490
Query: 799 YDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVT 858
D T L+ A DIV +L++ H E ++ D +G +AL A +
Sbjct: 491 AD-ADSRTALRAAAWGGHEDIVLNLLQ----HGAE------VNKADNEGRTALIAAAYM- 538
Query: 859 KEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTA-- 916
R++V+ L+++GA+V NHE A++ + H S
Sbjct: 539 --------GHREIVEHLLDHGAEV------NHEDVDGRTALSVAALCVPASKGHASVVSL 584
Query: 917 --DVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGY 974
D ++ + G TPLL+A + GH+ +V+ LL A VD D GR+ L AA G+
Sbjct: 585 LIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGH 644
Query: 975 LQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH 1034
V + LL A ++S GRT L +A+ G +V+ L+ D + TPLH
Sbjct: 645 ASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLL-DRGLDENHRDDAGWTPLH 703
Query: 1035 LAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTK 1094
+AA G +C+ L+E GA + D G+ P A+Q + + VQ+ L+ N +
Sbjct: 704 MAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSN-IDQRGY 762
Query: 1095 DGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRA 1154
DG +AA++G ++E L F ++ ++ T LA E + +
Sbjct: 763 DGRNALRVAALEGHRDIVELL--FSHGADVNCKDADGRPTLYILALE-NQLTMAEYFLEN 819
Query: 1155 GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETV 1214
GA+ + G TA+H++ GH ++ V+ + + ++ + L AA+ G + V
Sbjct: 820 GANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVV 879
Query: 1215 RELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAA 1274
+ L+ H G V G T L +AA G+ +VV++LL G + A
Sbjct: 880 QLLIEH--GAVVDHT-----------CNQGATALCIAAQEGHIDVVQVLLEH-GADPNHA 925
Query: 1275 SNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
++ G + +A GH I+ LL A L+
Sbjct: 926 -DQFGRTAMRVAAKNGHSQIIKLLEKYGASSLN 957
Score = 159 bits (386), Expect = 1e-37
Identities = 131/392 (33%), Positives = 184/392 (46%), Gaps = 27/392 (6%)
Query: 1017 DHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSE 1076
D+ A ++ +T L AA SG ++V LL+ GA+++ D G P+ AA+ +++
Sbjct: 384 DNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTK 443
Query: 1077 VVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPL 1136
VV + N + T +DG T AA G +V+ L+ GV + T L
Sbjct: 444 VVNCLIGCGAN-INHTDQDGWTALRSAAWGGHTEVVSALLY---AGVKVDCADADSRTAL 499
Query: 1137 QLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
+ AA GGH D+V L++ GA + G TA+ AA GH +++ +
Sbjct: 500 RAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDV 559
Query: 1197 LGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAE------SGLTPLHL 1250
G T L +AA VP + K A VSL+ GAE G+TPL +
Sbjct: 560 DGRTALSVAALC------------VPAS-KGHASV-VSLLIDRGAEVDHCDKDGMTPLLV 605
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AAY G+ +VV LLL G D N NG PL A GH S+V LL A + S D
Sbjct: 606 AAYEGHVDVVDLLLEG-GADVDHTDN-NGRTPLLAAASMGHASVVNTLLFWGAAV-DSID 662
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
G+T L IAS G+ ++V LL +G + N D GWTPLH AA GH + + L E GA
Sbjct: 663 SEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGA 722
Query: 1371 SPKSETNLNCAPIWFAASENHNDVLEYLLHKE 1402
N P A+ E H D ++ LL +
Sbjct: 723 RTNEIDNDGRIPFILASQEGHYDCVQILLENK 754
Score = 155 bits (375), Expect = 2e-36
Identities = 167/621 (26%), Positives = 267/621 (42%), Gaps = 54/621 (8%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G + AA G + ++N L+ +G +++ +T L +A VV L+G GA+
Sbjct: 395 NGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGAN 454
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
++ + T L AA + LL +G + A D T + AA G+ ++
Sbjct: 455 IN-HTDQDGWTALRSAAW-GGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVL 512
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LL+ G + + G T L A +IV HL+ DH E ++
Sbjct: 513 NLLQHGAEVNKADN-------EGRTALIAAAYMGHREIVEHLL----DHGAE------VN 555
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
D DG +AL A V VV LI+ GA+V + T A G
Sbjct: 556 HEDVDGRTALSVAALC----VPASKGHASVVSLLIDRGAEVD-HCDKDGMTPLLVAAYEG 610
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ DV+ ++ ADV N G TPLL A GH +VNTLL A VD D E
Sbjct: 611 HVDVVDLLLE--GGADVDHTDNN----GRTPLLAAASMGHASVVNTLLFWGAAVDSIDSE 664
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM 1021
GR+ L +A+ G ++V LL N + G T LH+AA G+ + + LI + A
Sbjct: 665 GRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALI-EQGAR 723
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
+ + + P LA+ G + ++LLE +NID G+ + AA + ++V+L
Sbjct: 724 TNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVEL- 782
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L H V DG +I A++ + + E ++ G + T L ++
Sbjct: 783 LFSHGADVNCKDADGRPTLYILALENQLTMAEYFLE---NGANVEASDAEGRTALHVSCW 839
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTP 1201
GH ++V+VL+ A + +A+ AA GH V+ ++ + + G T
Sbjct: 840 QGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATA 899
Query: 1202 LHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVR 1261
L IAA G + V+ LL H G + A + G T + +AA NG+ +++
Sbjct: 900 LCIAAQEGHIDVVQVLLEH--GADPNHAD-----------QFGRTAMRVAAKNGHSQIIK 946
Query: 1262 LLLNSAGVQADAASNENGYNP 1282
LL + AS+ NG +P
Sbjct: 947 LL------EKYGASSLNGCSP 961
Score = 138 bits (333), Expect = 3e-31
Identities = 113/374 (30%), Positives = 182/374 (48%), Gaps = 17/374 (4%)
Query: 1046 KLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAI 1105
+ LL+ GA+++ D G+ + AA + +VV L + + +L + G+T +AA
Sbjct: 380 RTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAH-GHTPLTLAAR 438
Query: 1106 QGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAG 1165
QG KV+ L+ G + T L+ AA GGH +VV L+ AG +
Sbjct: 439 QGHTKVVNCLIG---CGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS 495
Query: 1166 LTAVHLAAEHGHTN-VLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGT 1224
TA+ AA GH + VL++++ + + + G T L AAY G E V LL H
Sbjct: 496 RTALRAAAWGGHEDIVLNLLQHGAEVNKADNE-GRTALIAAAYMGHREIVEHLLDH-GAE 553
Query: 1225 VKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLH 1284
V E G + + V L + A G+ +VV LL++ G + D +++G PL
Sbjct: 554 VNHEDVDGRTALSVAA-------LCVPASKGHASVVSLLIDR-GAEVDHC-DKDGMTPLL 604
Query: 1285 LACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDK 1344
+A + GH+ +V LLL A++ H TD +G+T L A++ GH +V LL GA +++ D
Sbjct: 605 VAAYEGHVDVVDLLLEGGADVDH-TDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDS 663
Query: 1345 NGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G T L A+ G++ VV+ L + G + P+ AA E H + E L+ +
Sbjct: 664 EGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGAR 723
Query: 1405 TQSLMDDKRFVYNL 1418
T + +D R + L
Sbjct: 724 TNEIDNDGRIPFIL 737
Score = 126 bits (303), Expect = 1e-27
Identities = 105/299 (35%), Positives = 142/299 (47%), Gaps = 21/299 (7%)
Query: 1131 NDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTL 1190
N T L AA G DVV +LV GA E+ G T + LAA GHT V++ +
Sbjct: 395 NGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGAN 454
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHL 1250
+ + G T L AA+ G E V LL GV V A+S T L
Sbjct: 455 INHTDQDGWTALRSAAWGGHTEVVSALLY-----------AGVK-VDCADADSR-TALRA 501
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AA+ G+E++V LL G + + A NE G L A + GH IV LL AE+ H D
Sbjct: 502 AAWGGHEDIVLNLLQH-GAEVNKADNE-GRTALIAAAYMGHREIVEHLLDHGAEVNHE-D 558
Query: 1311 RHGKTGLHIAS-----THGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
G+T L +A+ + GH +V +L+ +GAE++ DK+G TPL AA GH++VV LL
Sbjct: 559 VDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLL 618
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKN 1424
E GA N P+ AAS H V+ LL S+ + R V ++ N
Sbjct: 619 LEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGN 677
Score = 89.0 bits (211), Expect = 2e-16
Identities = 53/159 (33%), Positives = 84/159 (52%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ PLL A G+ S+V LL A + + G T L +A+ + +V++ R L+D G
Sbjct: 632 GRTPLLAAASMGHASVVNTLLFWGAA--VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGL 689
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ + AG TPLH+AA EG + + A DN+ R P LA++ GH +++
Sbjct: 690 DENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQI 749
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L + K++I +R DG + +A+L GH D +LF G
Sbjct: 750 LLEN-KSNIDQRGYDGRNALRVAALEGHRDIVELLFSHG 787
Score = 74.5 bits (175), Expect = 4e-12
Identities = 46/159 (28%), Positives = 81/159 (50%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L +A G++ +V ELL + A+ + G L++ A + MA ++ GA
Sbjct: 764 GRNALRVAALEGHRDIV-ELLFSHGAD-VNCKDADGRPTLYILALENQLTMAEYFLENGA 821
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+A++ G+T LH++ +G +V+ A+ ADNE R+ + AA GH +++L
Sbjct: 822 NVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQL 881
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L + A + G+T + IA+ GH D +L + G
Sbjct: 882 LIE-HGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHG 919
Score = 72.1 bits (169), Expect = 2e-11
Identities = 48/163 (29%), Positives = 78/163 (47%), Gaps = 4/163 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELL---SAQTAEQLKATTPAGDTALHLAARRRDVDMARILVD 119
G+ L+ A G++ +V LL + E + T AL + A + + +L+D
Sbjct: 528 GRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLID 587
Query: 120 YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
GA VD + G TPL +AA EG +V A+ DN RTP+ AA GHA++
Sbjct: 588 RGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASV 647
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGV 222
+ L + A++ +G T++ IAS G+ + L +G+
Sbjct: 648 VNTLL-FWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGL 689
Score = 66.5 bits (155), Expect = 1e-09
Identities = 46/128 (35%), Positives = 71/128 (55%), Gaps = 3/128 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L ++ G+ MV+ L++ + A +AL AA + V + ++L+++GA
Sbjct: 830 GRTALHVSCWQGHMEMVQVLIAYHA--DVNAADNEKRSALQSAAWQGHVKVVQLLIEHGA 887
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VVD T G T L IAA EG +V+ A+ AD RT M +AA+NGH+ II+L
Sbjct: 888 VVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKL 947
Query: 183 LADKFKAS 190
L +K+ AS
Sbjct: 948 L-EKYGAS 954
Score = 63.7 bits (148), Expect = 7e-09
Identities = 52/164 (31%), Positives = 70/164 (42%), Gaps = 8/164 (4%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL LA G+ +V L+ + T G TAL AA ++ L+ G
Sbjct: 429 GHTPLTLAARQGHTKVVNCLIGC--GANINHTDQDGWTALRSAAWGGHTEVVSALLYAGV 486
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VD + +T L AA G E +V A ADNE RT + AA GH I+E
Sbjct: 487 KVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEH 546
Query: 183 LADKFKASIFERTKDGSTLMHIASL-----NGHADCAMMLFKKG 221
L D A + DG T + +A+L GHA +L +G
Sbjct: 547 LLD-HGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRG 589
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/111 (32%), Positives = 50/111 (45%), Gaps = 1/111 (0%)
Query: 112 DMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLA 171
D R L+D GA V+ + G+T L AA G +V A+ I D TP+ LA
Sbjct: 377 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA 436
Query: 172 AENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGV 222
A GH ++ L A+I +DG T + A+ GH + L GV
Sbjct: 437 ARQGHTKVVNCLIG-CGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGV 486
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/132 (27%), Positives = 66/132 (50%), Gaps = 2/132 (1%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K DG +++ A + + L+ G +V+ + + TALH++ +V+ L+ Y
Sbjct: 793 KDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAY 852
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
ADV+ ++R + L AA K +L++ GA + G T + +AA+ G++
Sbjct: 853 HADVNAADNEKR-SALQSAA-WQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHID 910
Query: 779 TLVLLLEDGGDP 790
+ +LLE G DP
Sbjct: 911 VVQVLLEHGADP 922
Score = 53.6 bits (123), Expect = 7e-06
Identities = 79/293 (26%), Positives = 120/293 (40%), Gaps = 35/293 (11%)
Query: 656 EKYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETL 715
E ++ G +H AA GH I L+++G + ND +A + V+ L
Sbjct: 691 ENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQIL 750
Query: 716 LGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
L +++ RG R L +AA D L L GA N DG +++ A
Sbjct: 751 LENKSNIDQRGYDGRNA-LRVAALEGHRDIVEL-LFSHGADVNCKDADGRPTLYILALEN 808
Query: 776 NLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESV 835
L LE+G + V D G T L ++C ++V+ LI + D
Sbjct: 809 QLTMAEYFLENGAN------VEASD-AEGRTALHVSCWQGHMEMVQVLIAYHAD------ 855
Query: 836 STAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFH 895
++A D + SAL A + VK VV+ LIE+GA V T + TA
Sbjct: 856 ----VNAADNEKRSALQSA--AWQGHVK-------VVQLLIEHGAVVD-HTCNQGATALC 901
Query: 896 YCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTL 948
A G+ DV+ ++ H AD N + G T + +A GH Q++ L
Sbjct: 902 IAAQEGHIDVVQVLLEH--GADP----NHADQFGRTAMRVAAKNGHSQIIKLL 948
Score = 51.2 bits (117), Expect = 4e-05
Identities = 44/159 (27%), Positives = 67/159 (42%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L A +G+ +V L+S L+ G T L LAAR+ + L+ GA
Sbjct: 396 GRTLLANAAYSGSLDVVNLLVSR--GADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGA 453
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
++ T+ G T L AA G +V AD + RT + AA GH I+
Sbjct: 454 NINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLN 513
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L + A + + +G T + A+ GH + L G
Sbjct: 514 LL-QHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 551
>AB033049-1|BAA86537.2| 1089|Homo sapiens KIAA1223 protein protein.
Length = 1089
Score = 211 bits (515), Expect = 2e-53
Identities = 169/535 (31%), Positives = 268/535 (50%), Gaps = 35/535 (6%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
+VV CLI GA+++ T + TA A G+ +V++ ++ D + A +R
Sbjct: 252 KVVNCLIGCGANIN-HTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSR----- 305
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
T L A GH +V LL + A V+ D EGR+AL AA G+ ++ + LL + A +N
Sbjct: 306 -TVLRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVN 364
Query: 990 SKARNGRTALHLAAM-----NGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEV 1044
+ +GRTAL +AA+ G+A +V LI D A +D TPL +AA G ++V
Sbjct: 365 HEDVDGRTALSVAALCVPASKGHASVVSLLI-DRGAEVDHCDKDGMTPLLVAAYEGHVDV 423
Query: 1045 CKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
LLLE GA++D TD G+ P+ AAA ++ VV L V + +G T IA+
Sbjct: 424 VDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGA-AVDSIDSEGRTVLSIAS 482
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
QG+V+V+ L+ DR G+ TPL +AA GH + L+ GA + +
Sbjct: 483 AQGNVEVVRTLL--DR-GLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDND 539
Query: 1165 GLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKL-GLTPLHIAAYYGQAETVRELLSHVPG 1223
G LA++ GH + + ++ N I + G L +AA G + V L SH
Sbjct: 540 GRIPFILASQEGHYDCVQILLE-NKSNIDQRGYDGRNALRVAALEGHRDIVELLFSH-GA 597
Query: 1224 TVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPL 1283
V + G + +L E+ LT +A Y L N A V+A S+ G L
Sbjct: 598 DVNCKDADGRPTLYILALENQLT---MAEY--------FLENGANVEA---SDAEGRTAL 643
Query: 1284 HLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATD 1343
H++C+ GHM +V +L++ A++ ++ D ++ L A+ GH ++V++L+ GA ++ T
Sbjct: 644 HVSCWQGHMEMVQVLIAYHADV-NAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTC 702
Query: 1344 KNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G T L AA+ GH++VV++L E GA P + AA H+ +++ L
Sbjct: 703 NQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL 757
Score = 198 bits (484), Expect = 1e-49
Identities = 166/564 (29%), Positives = 260/564 (46%), Gaps = 36/564 (6%)
Query: 871 VVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGW 930
VV L+ GAD+ ++ H H T A G+ V+ +I +N + GW
Sbjct: 220 VVNLLVSRGADLEIEDAHGH-TPLTLAARQGHTKVVNCLIG------CGANINHTDQDGW 272
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
T L A GH ++V+ LL +VD D + R+ L AA G+ + LL + A +N
Sbjct: 273 TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTVLRAAAWGGHEDIVLNLLQHGAEVNK 332
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAA-----ASGQIEVC 1045
GRTAL AA G+ +V+ L+ DH A ++ + +T L +AA + G V
Sbjct: 333 ADNEGRTALIAAAYMGHREIVEHLL-DHGAEVNHEDVDGRTALSVAALCVPASKGHASVV 391
Query: 1046 KLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAI 1105
LL++ GA +D D+ G P+ AA + +VV L L+ + V T +G T AA
Sbjct: 392 SLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGAD-VDHTDNNGRTPLLAAAS 450
Query: 1106 QGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAG 1165
G V+ L+ F V S ++ T L +A+ G+ +VVR L+ G + AG
Sbjct: 451 MGHASVVNTLL-FWGAAVDSIDSE--GRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAG 507
Query: 1166 LTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTV 1225
T +H+AA GH + + + G P +A+ G + V+ LL +
Sbjct: 508 WTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLEN----- 562
Query: 1226 KSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHL 1285
KS + G + G L +AA G+ ++V LL S G + + +G L++
Sbjct: 563 KSN-------IDQRGYD-GRNALRVAALEGHRDIVELLF-SHGADVNC-KDADGRPTLYI 612
Query: 1286 ACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKN 1345
+++ L A + ++D G+T LH++ GH +MV+VL+ A++NA D
Sbjct: 613 LALENQLTMAEYFLENGANV-EASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNE 671
Query: 1346 GWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
+ L AA GH+ VV+LL E GA N + AA E H DV++ LL EH
Sbjct: 672 KRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLL--EHGA 729
Query: 1406 QSLMDDKRFVYNLMVCSKN-HNNI 1428
D+ + V +KN H+ I
Sbjct: 730 DPNHADQFGRTAMRVAAKNGHSQI 753
Score = 175 bits (426), Expect = 1e-42
Identities = 161/573 (28%), Positives = 266/573 (46%), Gaps = 39/573 (6%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G + AAR GH ++N L+ G +++ T D +TAL A VV LL G V
Sbjct: 238 GHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKV 297
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
R T L AA D L LL+ GA NKA +G T + AA G+ +
Sbjct: 298 DCADADSR-TVLRAAAWGGHED-IVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEH 355
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH--LIEFVKDHKGESVSTAFI 840
LL+ G + ++ V G T L +A C+P H ++ + D E +
Sbjct: 356 LLDHGAE-------VNHEDVDGRTALSVAAL-CVPASKGHASVVSLLIDRGAE------V 401
Query: 841 DAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIA 900
D D+DG + L V E + VV L+E GADV T +N T A
Sbjct: 402 DHCDKDGMTPL----LVAAYEGHV-----DVVDLLLEGGADVD-HTDNNGRTPLLAAASM 451
Query: 901 GNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDV 960
G+ V+ ++ A++ +S G T L IA +G++++V TLL + D
Sbjct: 452 GHASVVNTLLFW------GAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDD 505
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
G + LH+AA G+ +C+AL+ A N +GR LA+ G+ V+ L+ ++ +
Sbjct: 506 AGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILL-ENKS 564
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQL 1080
ID + L +AA G ++ +LL GA+++ D G+ ++ A N + +
Sbjct: 565 NIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEY 624
Query: 1081 FLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAA 1140
FL+ N V A+ +G T H++ QG +++++ L+ + V +A N+ + LQ AA
Sbjct: 625 FLENGAN-VEASDAEGRTALHVSCWQGHMEMVQVLIAY-HADVNAADNEKRSA--LQSAA 680
Query: 1141 EGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLT 1200
GH VV++L+ GA G TA+ +AA+ GH +V+ V+ + + G T
Sbjct: 681 WQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRT 740
Query: 1201 PLHIAAYYGQAETVRELLSHVPGTVKSEAPTGV 1233
+ +AA G ++ ++ L + ++ +P+ V
Sbjct: 741 AMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPV 773
Score = 160 bits (389), Expect = 4e-38
Identities = 175/633 (27%), Positives = 276/633 (43%), Gaps = 58/633 (9%)
Query: 679 INTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAA 738
I TLL G SV+ ++ T L A S VV L+ GAD+ I TPL +AA
Sbjct: 188 IRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDA-HGHTPLTLAA 246
Query: 739 RIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCI 798
R K L+ GA N +DG T + AA G+ + LL G KV
Sbjct: 247 R-QGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAG------VKVDC 299
Query: 799 YDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVT 858
D T L+ A DIV +L++ H E ++ D +G +AL A +
Sbjct: 300 AD-ADSRTVLRAAAWGGHEDIVLNLLQ----HGAE------VNKADNEGRTALIAAAYM- 347
Query: 859 KEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTA-- 916
R++V+ L+++GA+V NHE A++ + H S
Sbjct: 348 --------GHREIVEHLLDHGAEV------NHEDVDGRTALSVAALCVPASKGHASVVSL 393
Query: 917 --DVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGY 974
D ++ + G TPLL+A + GH+ +V+ LL A VD D GR+ L AA G+
Sbjct: 394 LIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGH 453
Query: 975 LQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH 1034
V + LL A ++S GRT L +A+ G +V+ L+ D + TPLH
Sbjct: 454 ASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLL-DRGLDENHRDDAGWTPLH 512
Query: 1035 LAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTK 1094
+AA G +C+ L+E GA + D G+ P A+Q + + VQ+ L+ N +
Sbjct: 513 MAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSN-IDQRGY 571
Query: 1095 DGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRA 1154
DG +AA++G ++E L F ++ ++ T LA E + +
Sbjct: 572 DGRNALRVAALEGHRDIVELL--FSHGADVNCKDADGRPTLYILALE-NQLTMAEYFLEN 628
Query: 1155 GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETV 1214
GA+ + G TA+H++ GH ++ V+ + + ++ + L AA+ G + V
Sbjct: 629 GANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVV 688
Query: 1215 RELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAA 1274
+ L+ H G V G T L +AA G+ +VV++LL G + A
Sbjct: 689 QLLIEH--GAVVDHT-----------CNQGATALCIAAQEGHIDVVQVLLEH-GADPNHA 734
Query: 1275 SNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
++ G + +A GH I+ LL A L+
Sbjct: 735 -DQFGRTAMRVAAKNGHSQIIKLLEKYGASSLN 766
Score = 159 bits (385), Expect = 1e-37
Identities = 131/392 (33%), Positives = 184/392 (46%), Gaps = 27/392 (6%)
Query: 1017 DHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSE 1076
D+ A ++ +T L AA SG ++V LL+ GA+++ D G P+ AA+ +++
Sbjct: 193 DNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTK 252
Query: 1077 VVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPL 1136
VV + N + T +DG T AA G +V+ L+ GV + T L
Sbjct: 253 VVNCLIGCGAN-INHTDQDGWTALRSAAWGGHTEVVSALLY---AGVKVDCADADSRTVL 308
Query: 1137 QLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
+ AA GGH D+V L++ GA + G TA+ AA GH +++ +
Sbjct: 309 RAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDV 368
Query: 1197 LGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAE------SGLTPLHL 1250
G T L +AA VP + K A VSL+ GAE G+TPL +
Sbjct: 369 DGRTALSVAALC------------VPAS-KGHASV-VSLLIDRGAEVDHCDKDGMTPLLV 414
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AAY G+ +VV LLL G D N NG PL A GH S+V LL A + S D
Sbjct: 415 AAYEGHVDVVDLLLEG-GADVDHTDN-NGRTPLLAAASMGHASVVNTLLFWGAAV-DSID 471
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
G+T L IAS G+ ++V LL +G + N D GWTPLH AA GH + + L E GA
Sbjct: 472 SEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGA 531
Query: 1371 SPKSETNLNCAPIWFAASENHNDVLEYLLHKE 1402
N P A+ E H D ++ LL +
Sbjct: 532 RTNEIDNDGRIPFILASQEGHYDCVQILLENK 563
Score = 154 bits (374), Expect = 3e-36
Identities = 167/621 (26%), Positives = 267/621 (42%), Gaps = 54/621 (8%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G + AA G + ++N L+ +G +++ +T L +A VV L+G GA+
Sbjct: 204 NGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGAN 263
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
++ + T L AA + LL +G + A D T + AA G+ ++
Sbjct: 264 IN-HTDQDGWTALRSAAW-GGHTEVVSALLYAGVKVDCADADSRTVLRAAAWGGHEDIVL 321
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LL+ G + + G T L A +IV HL+ DH E ++
Sbjct: 322 NLLQHGAEVNKADN-------EGRTALIAAAYMGHREIVEHLL----DHGAE------VN 364
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
D DG +AL A V VV LI+ GA+V + T A G
Sbjct: 365 HEDVDGRTALSVAALC----VPASKGHASVVSLLIDRGAEVD-HCDKDGMTPLLVAAYEG 419
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ DV+ ++ ADV N G TPLL A GH +VNTLL A VD D E
Sbjct: 420 HVDVVDLLLE--GGADVDHTDNN----GRTPLLAAASMGHASVVNTLLFWGAAVDSIDSE 473
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM 1021
GR+ L +A+ G ++V LL N + G T LH+AA G+ + + LI + A
Sbjct: 474 GRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALI-EQGAR 532
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
+ + + P LA+ G + ++LLE +NID G+ + AA + ++V+L
Sbjct: 533 TNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVEL- 591
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L H V DG +I A++ + + E ++ G + T L ++
Sbjct: 592 LFSHGADVNCKDADGRPTLYILALENQLTMAEYFLE---NGANVEASDAEGRTALHVSCW 648
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTP 1201
GH ++V+VL+ A + +A+ AA GH V+ ++ + + G T
Sbjct: 649 QGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATA 708
Query: 1202 LHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVR 1261
L IAA G + V+ LL H G + A + G T + +AA NG+ +++
Sbjct: 709 LCIAAQEGHIDVVQVLLEH--GADPNHAD-----------QFGRTAMRVAAKNGHSQIIK 755
Query: 1262 LLLNSAGVQADAASNENGYNP 1282
LL + AS+ NG +P
Sbjct: 756 LL------EKYGASSLNGCSP 770
Score = 136 bits (329), Expect = 8e-31
Identities = 112/374 (29%), Positives = 181/374 (48%), Gaps = 17/374 (4%)
Query: 1046 KLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAI 1105
+ LL+ GA+++ D G+ + AA + +VV L + + +L + G+T +AA
Sbjct: 189 RTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAH-GHTPLTLAAR 247
Query: 1106 QGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAG 1165
QG KV+ L+ G + T L+ AA GGH +VV L+ AG +
Sbjct: 248 QGHTKVVNCLIG---CGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS 304
Query: 1166 LTAVHLAAEHGHTN-VLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGT 1224
T + AA GH + VL++++ + + + G T L AAY G E V LL H
Sbjct: 305 RTVLRAAAWGGHEDIVLNLLQHGAEVNKADNE-GRTALIAAAYMGHREIVEHLLDH-GAE 362
Query: 1225 VKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLH 1284
V E G + + V L + A G+ +VV LL++ G + D +++G PL
Sbjct: 363 VNHEDVDGRTALSVAA-------LCVPASKGHASVVSLLIDR-GAEVDHC-DKDGMTPLL 413
Query: 1285 LACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDK 1344
+A + GH+ +V LLL A++ H TD +G+T L A++ GH +V LL GA +++ D
Sbjct: 414 VAAYEGHVDVVDLLLEGGADVDH-TDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDS 472
Query: 1345 NGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G T L A+ G++ VV+ L + G + P+ AA E H + E L+ +
Sbjct: 473 EGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGAR 532
Query: 1405 TQSLMDDKRFVYNL 1418
T + +D R + L
Sbjct: 533 TNEIDNDGRIPFIL 546
Score = 125 bits (302), Expect = 1e-27
Identities = 105/299 (35%), Positives = 142/299 (47%), Gaps = 21/299 (7%)
Query: 1131 NDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTL 1190
N T L AA G DVV +LV GA E+ G T + LAA GHT V++ +
Sbjct: 204 NGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGAN 263
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHL 1250
+ + G T L AA+ G E V LL GV V A+S T L
Sbjct: 264 INHTDQDGWTALRSAAWGGHTEVVSALLY-----------AGVK-VDCADADSR-TVLRA 310
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AA+ G+E++V LL G + + A NE G L A + GH IV LL AE+ H D
Sbjct: 311 AAWGGHEDIVLNLLQH-GAEVNKADNE-GRTALIAAAYMGHREIVEHLLDHGAEVNHE-D 367
Query: 1311 RHGKTGLHIAS-----THGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
G+T L +A+ + GH +V +L+ +GAE++ DK+G TPL AA GH++VV LL
Sbjct: 368 VDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLL 427
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKN 1424
E GA N P+ AAS H V+ LL S+ + R V ++ N
Sbjct: 428 LEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGN 486
Score = 89.0 bits (211), Expect = 2e-16
Identities = 53/159 (33%), Positives = 84/159 (52%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ PLL A G+ S+V LL A + + G T L +A+ + +V++ R L+D G
Sbjct: 441 GRTPLLAAASMGHASVVNTLLFWGAA--VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGL 498
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ + AG TPLH+AA EG + + A DN+ R P LA++ GH +++
Sbjct: 499 DENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQI 558
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L + K++I +R DG + +A+L GH D +LF G
Sbjct: 559 LLEN-KSNIDQRGYDGRNALRVAALEGHRDIVELLFSHG 596
Score = 74.5 bits (175), Expect = 4e-12
Identities = 46/159 (28%), Positives = 81/159 (50%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L +A G++ +V ELL + A+ + G L++ A + MA ++ GA
Sbjct: 573 GRNALRVAALEGHRDIV-ELLFSHGAD-VNCKDADGRPTLYILALENQLTMAEYFLENGA 630
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+A++ G+T LH++ +G +V+ A+ ADNE R+ + AA GH +++L
Sbjct: 631 NVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQL 690
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L + A + G+T + IA+ GH D +L + G
Sbjct: 691 LIE-HGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHG 728
Score = 72.1 bits (169), Expect = 2e-11
Identities = 48/163 (29%), Positives = 78/163 (47%), Gaps = 4/163 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELL---SAQTAEQLKATTPAGDTALHLAARRRDVDMARILVD 119
G+ L+ A G++ +V LL + E + T AL + A + + +L+D
Sbjct: 337 GRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLID 396
Query: 120 YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
GA VD + G TPL +AA EG +V A+ DN RTP+ AA GHA++
Sbjct: 397 RGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASV 456
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGV 222
+ L + A++ +G T++ IAS G+ + L +G+
Sbjct: 457 VNTLL-FWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGL 498
Score = 66.5 bits (155), Expect = 1e-09
Identities = 46/128 (35%), Positives = 71/128 (55%), Gaps = 3/128 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L ++ G+ MV+ L++ + A +AL AA + V + ++L+++GA
Sbjct: 639 GRTALHVSCWQGHMEMVQVLIAYHA--DVNAADNEKRSALQSAAWQGHVKVVQLLIEHGA 696
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VVD T G T L IAA EG +V+ A+ AD RT M +AA+NGH+ II+L
Sbjct: 697 VVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKL 756
Query: 183 LADKFKAS 190
L +K+ AS
Sbjct: 757 L-EKYGAS 763
Score = 63.3 bits (147), Expect = 9e-09
Identities = 52/164 (31%), Positives = 70/164 (42%), Gaps = 8/164 (4%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL LA G+ +V L+ + T G TAL AA ++ L+ G
Sbjct: 238 GHTPLTLAARQGHTKVVNCLIGC--GANINHTDQDGWTALRSAAWGGHTEVVSALLYAGV 295
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VD + +T L AA G E +V A ADNE RT + AA GH I+E
Sbjct: 296 KVDCADADSRTVLRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEH 355
Query: 183 LADKFKASIFERTKDGSTLMHIASL-----NGHADCAMMLFKKG 221
L D A + DG T + +A+L GHA +L +G
Sbjct: 356 LLD-HGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRG 398
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/111 (32%), Positives = 50/111 (45%), Gaps = 1/111 (0%)
Query: 112 DMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLA 171
D R L+D GA V+ + G+T L AA G +V A+ I D TP+ LA
Sbjct: 186 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA 245
Query: 172 AENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGV 222
A GH ++ L A+I +DG T + A+ GH + L GV
Sbjct: 246 ARQGHTKVVNCLIG-CGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGV 295
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/132 (27%), Positives = 66/132 (50%), Gaps = 2/132 (1%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K DG +++ A + + L+ G +V+ + + TALH++ +V+ L+ Y
Sbjct: 602 KDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAY 661
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
ADV+ ++R + L AA K +L++ GA + G T + +AA+ G++
Sbjct: 662 HADVNAADNEKR-SALQSAA-WQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHID 719
Query: 779 TLVLLLEDGGDP 790
+ +LLE G DP
Sbjct: 720 VVQVLLEHGADP 731
Score = 53.6 bits (123), Expect = 7e-06
Identities = 79/293 (26%), Positives = 120/293 (40%), Gaps = 35/293 (11%)
Query: 656 EKYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETL 715
E ++ G +H AA GH I L+++G + ND +A + V+ L
Sbjct: 500 ENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQIL 559
Query: 716 LGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
L +++ RG R L +AA D L L GA N DG +++ A
Sbjct: 560 LENKSNIDQRGYDGRNA-LRVAALEGHRDIVEL-LFSHGADVNCKDADGRPTLYILALEN 617
Query: 776 NLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESV 835
L LE+G + V D G T L ++C ++V+ LI + D
Sbjct: 618 QLTMAEYFLENGAN------VEASD-AEGRTALHVSCWQGHMEMVQVLIAYHAD------ 664
Query: 836 STAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFH 895
++A D + SAL A + VK VV+ LIE+GA V T + TA
Sbjct: 665 ----VNAADNEKRSALQSA--AWQGHVK-------VVQLLIEHGAVVD-HTCNQGATALC 710
Query: 896 YCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTL 948
A G+ DV+ ++ H AD N + G T + +A GH Q++ L
Sbjct: 711 IAAQEGHIDVVQVLLEH--GADP----NHADQFGRTAMRVAAKNGHSQIIKLL 757
Score = 50.8 bits (116), Expect = 5e-05
Identities = 44/159 (27%), Positives = 67/159 (42%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L A +G+ +V L+S L+ G T L LAAR+ + L+ GA
Sbjct: 205 GRTLLANAAYSGSLDVVNLLVSR--GADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGA 262
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
++ T+ G T L AA G +V AD + RT + AA GH I+
Sbjct: 263 NINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTVLRAAAWGGHEDIVLN 322
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L + A + + +G T + A+ GH + L G
Sbjct: 323 LL-QHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 360
>AK127496-1|BAC87007.1| 1375|Homo sapiens protein ( Homo sapiens cDNA
FLJ45589 fis, clone BRTHA3014547, weakly similar to
Ankyrin 1. ).
Length = 1375
Score = 208 bits (508), Expect = 2e-52
Identities = 168/535 (31%), Positives = 267/535 (49%), Gaps = 35/535 (6%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
+VV CLI GA+++ T + TA A G+ +V++ ++ D + A +R
Sbjct: 538 KVVNCLIGCGANIN-HTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSR----- 591
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
T L A G +V LL + A V+ D EGR+AL AA G+ ++ + LL + A +N
Sbjct: 592 -TALRAAAWGGREDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVN 650
Query: 990 SKARNGRTALHLAAM-----NGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEV 1044
+ +GRTAL +AA+ G+A +V LI D A +D TPL +AA G ++V
Sbjct: 651 HEDVDGRTALSVAALCVPASKGHASVVSLLI-DRGAEVDHCDKDGMTPLLVAAYEGHVDV 709
Query: 1045 CKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
LLLE GA++D TD G+ P+ AAA ++ VV L V + +G T IA+
Sbjct: 710 VDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGA-AVDSIDSEGRTVLSIAS 768
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
QG+V+V+ L+ DR G+ TPL +AA GH + L+ GA + +
Sbjct: 769 AQGNVEVVRTLL--DR-GLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDND 825
Query: 1165 GLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKL-GLTPLHIAAYYGQAETVRELLSHVPG 1223
G LA++ GH + + ++ N I + G L +AA G + V L SH
Sbjct: 826 GRIPFILASQEGHYDCVQILLE-NKSNIDQRGYDGRNALRVAALEGHRDIVELLFSH-GA 883
Query: 1224 TVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPL 1283
V + G + +L E+ LT +A Y L N A V+A S+ G L
Sbjct: 884 DVNCKDADGRPTLYILALENQLT---MAEY--------FLENGANVEA---SDAEGRTAL 929
Query: 1284 HLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATD 1343
H++C+ GHM +V +L++ A++ ++ D ++ L A+ GH ++V++L+ GA ++ T
Sbjct: 930 HVSCWQGHMEMVQVLIAYHADV-NAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTC 988
Query: 1344 KNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G T L AA+ GH++VV++L E GA P + AA H+ +++ L
Sbjct: 989 NQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL 1043
Score = 198 bits (484), Expect = 1e-49
Identities = 167/564 (29%), Positives = 260/564 (46%), Gaps = 36/564 (6%)
Query: 871 VVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGW 930
VV L+ GAD+ ++ H H T A G+ V+ +I +N + GW
Sbjct: 506 VVNLLVSRGADLEIEDAHGH-TPLTLAARQGHTKVVNCLIG------CGANINHTDQDGW 558
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
T L A GH ++V+ LL +VD D + R+AL AA G + LL + A +N
Sbjct: 559 TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGREDIVLNLLQHGAEVNK 618
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAA-----ASGQIEVC 1045
GRTAL AA G+ +V+ L+ DH A ++ + +T L +AA + G V
Sbjct: 619 ADNEGRTALIAAAYMGHREIVEHLL-DHGAEVNHEDVDGRTALSVAALCVPASKGHASVV 677
Query: 1046 KLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAI 1105
LL++ GA +D D+ G P+ AA + +VV L L+ + V T +G T AA
Sbjct: 678 SLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGAD-VDHTDNNGRTPLLAAAS 736
Query: 1106 QGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAG 1165
G V+ L+ F V S ++ T L +A+ G+ +VVR L+ G + AG
Sbjct: 737 MGHASVVNTLL-FWGAAVDSIDSE--GRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAG 793
Query: 1166 LTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTV 1225
T +H+AA GH + + + G P +A+ G + V+ LL +
Sbjct: 794 WTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLEN----- 848
Query: 1226 KSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHL 1285
KS + G + G L +AA G+ ++V LL S G + + +G L++
Sbjct: 849 KSN-------IDQRGYD-GRNALRVAALEGHRDIVELLF-SHGADVNC-KDADGRPTLYI 898
Query: 1286 ACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKN 1345
+++ L A + ++D G+T LH++ GH +MV+VL+ A++NA D
Sbjct: 899 LALENQLTMAEYFLENGANV-EASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNE 957
Query: 1346 GWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
+ L AA GH+ VV+LL E GA N + AA E H DV++ LL EH
Sbjct: 958 KRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLL--EHGA 1015
Query: 1406 QSLMDDKRFVYNLMVCSKN-HNNI 1428
D+ + V +KN H+ I
Sbjct: 1016 DPNHADQFGRTAMRVAAKNGHSQI 1039
Score = 175 bits (426), Expect = 1e-42
Identities = 161/573 (28%), Positives = 266/573 (46%), Gaps = 39/573 (6%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G + AAR GH ++N L+ G +++ T D +TAL A VV LL G V
Sbjct: 524 GHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKV 583
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
R T L AA D L LL+ GA NKA +G T + AA G+ +
Sbjct: 584 DCADADSR-TALRAAAWGGRED-IVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEH 641
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH--LIEFVKDHKGESVSTAFI 840
LL+ G + ++ V G T L +A C+P H ++ + D E +
Sbjct: 642 LLDHGAE-------VNHEDVDGRTALSVAAL-CVPASKGHASVVSLLIDRGAE------V 687
Query: 841 DAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIA 900
D D+DG + L V E + VV L+E GADV T +N T A
Sbjct: 688 DHCDKDGMTPL----LVAAYEGHV-----DVVDLLLEGGADVD-HTDNNGRTPLLAAASM 737
Query: 901 GNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDV 960
G+ V+ ++ A++ +S G T L IA +G++++V TLL + D
Sbjct: 738 GHASVVNTLLFW------GAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDD 791
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
G + LH+AA G+ +C+AL+ A N +GR LA+ G+ V+ L+ ++ +
Sbjct: 792 AGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILL-ENKS 850
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQL 1080
ID + L +AA G ++ +LL GA+++ D G+ ++ A N + +
Sbjct: 851 NIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEY 910
Query: 1081 FLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAA 1140
FL+ N V A+ +G T H++ QG +++++ L+ + V +A N+ + LQ AA
Sbjct: 911 FLENGAN-VEASDAEGRTALHVSCWQGHMEMVQVLIAY-HADVNAADNEKRSA--LQSAA 966
Query: 1141 EGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLT 1200
GH VV++L+ GA G TA+ +AA+ GH +V+ V+ + + G T
Sbjct: 967 WQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRT 1026
Query: 1201 PLHIAAYYGQAETVRELLSHVPGTVKSEAPTGV 1233
+ +AA G ++ ++ L + ++ +P+ V
Sbjct: 1027 AMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPV 1059
Score = 161 bits (391), Expect = 2e-38
Identities = 175/633 (27%), Positives = 276/633 (43%), Gaps = 58/633 (9%)
Query: 679 INTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAA 738
I TLL G SV+ ++ T L A S VV L+ GAD+ I TPL +AA
Sbjct: 474 IRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDA-HGHTPLTLAA 532
Query: 739 RIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCI 798
R K L+ GA N +DG T + AA G+ + LL G KV
Sbjct: 533 R-QGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAG------VKVDC 585
Query: 799 YDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVT 858
D T L+ A DIV +L++ H E ++ D +G +AL A +
Sbjct: 586 AD-ADSRTALRAAAWGGREDIVLNLLQ----HGAE------VNKADNEGRTALIAAAYM- 633
Query: 859 KEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTA-- 916
R++V+ L+++GA+V NHE A++ + H S
Sbjct: 634 --------GHREIVEHLLDHGAEV------NHEDVDGRTALSVAALCVPASKGHASVVSL 679
Query: 917 --DVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGY 974
D ++ + G TPLL+A + GH+ +V+ LL A VD D GR+ L AA G+
Sbjct: 680 LIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGH 739
Query: 975 LQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH 1034
V + LL A ++S GRT L +A+ G +V+ L+ D + TPLH
Sbjct: 740 ASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLL-DRGLDENHRDDAGWTPLH 798
Query: 1035 LAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTK 1094
+AA G +C+ L+E GA + D G+ P A+Q + + VQ+ L+ N +
Sbjct: 799 MAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSN-IDQRGY 857
Query: 1095 DGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRA 1154
DG +AA++G ++E L F ++ ++ T LA E + +
Sbjct: 858 DGRNALRVAALEGHRDIVELL--FSHGADVNCKDADGRPTLYILALE-NQLTMAEYFLEN 914
Query: 1155 GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETV 1214
GA+ + G TA+H++ GH ++ V+ + + ++ + L AA+ G + V
Sbjct: 915 GANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVV 974
Query: 1215 RELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAA 1274
+ L+ H G V G T L +AA G+ +VV++LL G + A
Sbjct: 975 QLLIEH--GAVVDHT-----------CNQGATALCIAAQEGHIDVVQVLLEH-GADPNHA 1020
Query: 1275 SNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
++ G + +A GH I+ LL A L+
Sbjct: 1021 -DQFGRTAMRVAAKNGHSQIIKLLEKYGASSLN 1052
Score = 156 bits (378), Expect = 9e-37
Identities = 130/392 (33%), Positives = 183/392 (46%), Gaps = 27/392 (6%)
Query: 1017 DHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSE 1076
D+ A ++ +T L AA SG ++V LL+ GA+++ D G P+ AA+ +++
Sbjct: 479 DNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTK 538
Query: 1077 VVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPL 1136
VV + N + T +DG T AA G +V+ L+ GV + T L
Sbjct: 539 VVNCLIGCGAN-INHTDQDGWTALRSAAWGGHTEVVSALLY---AGVKVDCADADSRTAL 594
Query: 1137 QLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
+ AA GG D+V L++ GA + G TA+ AA GH +++ +
Sbjct: 595 RAAAWGGREDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDV 654
Query: 1197 LGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAE------SGLTPLHL 1250
G T L +AA VP + K A VSL+ GAE G+TPL +
Sbjct: 655 DGRTALSVAALC------------VPAS-KGHASV-VSLLIDRGAEVDHCDKDGMTPLLV 700
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AAY G+ +VV LLL G D N NG PL A GH S+V LL A + S D
Sbjct: 701 AAYEGHVDVVDLLLEG-GADVDHTDN-NGRTPLLAAASMGHASVVNTLLFWGAAV-DSID 757
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
G+T L IAS G+ ++V LL +G + N D GWTPLH AA GH + + L E GA
Sbjct: 758 SEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGA 817
Query: 1371 SPKSETNLNCAPIWFAASENHNDVLEYLLHKE 1402
N P A+ E H D ++ LL +
Sbjct: 818 RTNEIDNDGRIPFILASQEGHYDCVQILLENK 849
Score = 154 bits (374), Expect = 3e-36
Identities = 167/621 (26%), Positives = 266/621 (42%), Gaps = 54/621 (8%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G + AA G + ++N L+ +G +++ +T L +A VV L+G GA+
Sbjct: 490 NGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGAN 549
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
++ + T L AA + LL +G + A D T + AA G ++
Sbjct: 550 IN-HTDQDGWTALRSAAW-GGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGREDIVL 607
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LL+ G + + G T L A +IV HL+ DH E ++
Sbjct: 608 NLLQHGAEVNKADN-------EGRTALIAAAYMGHREIVEHLL----DHGAE------VN 650
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
D DG +AL A V VV LI+ GA+V + T A G
Sbjct: 651 HEDVDGRTALSVAALC----VPASKGHASVVSLLIDRGAEVD-HCDKDGMTPLLVAAYEG 705
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ DV+ ++ ADV N G TPLL A GH +VNTLL A VD D E
Sbjct: 706 HVDVVDLLLE--GGADVDHTDNN----GRTPLLAAASMGHASVVNTLLFWGAAVDSIDSE 759
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM 1021
GR+ L +A+ G ++V LL N + G T LH+AA G+ + + LI + A
Sbjct: 760 GRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALI-EQGAR 818
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
+ + + P LA+ G + ++LLE +NID G+ + AA + ++V+L
Sbjct: 819 TNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVEL- 877
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L H V DG +I A++ + + E ++ G + T L ++
Sbjct: 878 LFSHGADVNCKDADGRPTLYILALENQLTMAEYFLE---NGANVEASDAEGRTALHVSCW 934
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTP 1201
GH ++V+VL+ A + +A+ AA GH V+ ++ + + G T
Sbjct: 935 QGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATA 994
Query: 1202 LHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVR 1261
L IAA G + V+ LL H G + A + G T + +AA NG+ +++
Sbjct: 995 LCIAAQEGHIDVVQVLLEH--GADPNHAD-----------QFGRTAMRVAAKNGHSQIIK 1041
Query: 1262 LLLNSAGVQADAASNENGYNP 1282
LL + AS+ NG +P
Sbjct: 1042 LL------EKYGASSLNGCSP 1056
Score = 134 bits (325), Expect = 2e-30
Identities = 112/374 (29%), Positives = 181/374 (48%), Gaps = 17/374 (4%)
Query: 1046 KLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAI 1105
+ LL+ GA+++ D G+ + AA + +VV L + + +L + G+T +AA
Sbjct: 475 RTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAH-GHTPLTLAAR 533
Query: 1106 QGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAG 1165
QG KV+ L+ G + T L+ AA GGH +VV L+ AG +
Sbjct: 534 QGHTKVVNCLIG---CGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS 590
Query: 1166 LTAVHLAAEHGHTN-VLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGT 1224
TA+ AA G + VL++++ + + + G T L AAY G E V LL H
Sbjct: 591 RTALRAAAWGGREDIVLNLLQHGAEVNKADNE-GRTALIAAAYMGHREIVEHLLDH-GAE 648
Query: 1225 VKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLH 1284
V E G + + V L + A G+ +VV LL++ G + D +++G PL
Sbjct: 649 VNHEDVDGRTALSVAA-------LCVPASKGHASVVSLLIDR-GAEVDHC-DKDGMTPLL 699
Query: 1285 LACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDK 1344
+A + GH+ +V LLL A++ H TD +G+T L A++ GH +V LL GA +++ D
Sbjct: 700 VAAYEGHVDVVDLLLEGGADVDH-TDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDS 758
Query: 1345 NGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G T L A+ G++ VV+ L + G + P+ AA E H + E L+ +
Sbjct: 759 EGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGAR 818
Query: 1405 TQSLMDDKRFVYNL 1418
T + +D R + L
Sbjct: 819 TNEIDNDGRIPFIL 832
Score = 125 bits (302), Expect = 1e-27
Identities = 105/299 (35%), Positives = 141/299 (47%), Gaps = 21/299 (7%)
Query: 1131 NDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTL 1190
N T L AA G DVV +LV GA E+ G T + LAA GHT V++ +
Sbjct: 490 NGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGAN 549
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHL 1250
+ + G T L AA+ G E V LL GV V A+S T L
Sbjct: 550 INHTDQDGWTALRSAAWGGHTEVVSALLY-----------AGVK-VDCADADSR-TALRA 596
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AA+ G E++V LL G + + A NE G L A + GH IV LL AE+ H D
Sbjct: 597 AAWGGREDIVLNLLQH-GAEVNKADNE-GRTALIAAAYMGHREIVEHLLDHGAEVNHE-D 653
Query: 1311 RHGKTGLHIAS-----THGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
G+T L +A+ + GH +V +L+ +GAE++ DK+G TPL AA GH++VV LL
Sbjct: 654 VDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLL 713
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKN 1424
E GA N P+ AAS H V+ LL S+ + R V ++ N
Sbjct: 714 LEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGN 772
Score = 89.0 bits (211), Expect = 2e-16
Identities = 53/159 (33%), Positives = 84/159 (52%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ PLL A G+ S+V LL A + + G T L +A+ + +V++ R L+D G
Sbjct: 727 GRTPLLAAASMGHASVVNTLLFWGAA--VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGL 784
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ + AG TPLH+AA EG + + A DN+ R P LA++ GH +++
Sbjct: 785 DENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQI 844
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L + K++I +R DG + +A+L GH D +LF G
Sbjct: 845 LLEN-KSNIDQRGYDGRNALRVAALEGHRDIVELLFSHG 882
Score = 74.5 bits (175), Expect = 4e-12
Identities = 46/159 (28%), Positives = 81/159 (50%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L +A G++ +V ELL + A+ + G L++ A + MA ++ GA
Sbjct: 859 GRNALRVAALEGHRDIV-ELLFSHGAD-VNCKDADGRPTLYILALENQLTMAEYFLENGA 916
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+A++ G+T LH++ +G +V+ A+ ADNE R+ + AA GH +++L
Sbjct: 917 NVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQL 976
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L + A + G+T + IA+ GH D +L + G
Sbjct: 977 LIE-HGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHG 1014
Score = 72.1 bits (169), Expect = 2e-11
Identities = 48/163 (29%), Positives = 78/163 (47%), Gaps = 4/163 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELL---SAQTAEQLKATTPAGDTALHLAARRRDVDMARILVD 119
G+ L+ A G++ +V LL + E + T AL + A + + +L+D
Sbjct: 623 GRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLID 682
Query: 120 YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
GA VD + G TPL +AA EG +V A+ DN RTP+ AA GHA++
Sbjct: 683 RGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASV 742
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGV 222
+ L + A++ +G T++ IAS G+ + L +G+
Sbjct: 743 VNTLL-FWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGL 784
Score = 66.5 bits (155), Expect = 1e-09
Identities = 46/128 (35%), Positives = 71/128 (55%), Gaps = 3/128 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L ++ G+ MV+ L++ + A +AL AA + V + ++L+++GA
Sbjct: 925 GRTALHVSCWQGHMEMVQVLIAYHA--DVNAADNEKRSALQSAAWQGHVKVVQLLIEHGA 982
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VVD T G T L IAA EG +V+ A+ AD RT M +AA+NGH+ II+L
Sbjct: 983 VVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKL 1042
Query: 183 LADKFKAS 190
L +K+ AS
Sbjct: 1043 L-EKYGAS 1049
Score = 63.3 bits (147), Expect = 9e-09
Identities = 52/164 (31%), Positives = 70/164 (42%), Gaps = 8/164 (4%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL LA G+ +V L+ + T G TAL AA ++ L+ G
Sbjct: 524 GHTPLTLAARQGHTKVVNCLIGC--GANINHTDQDGWTALRSAAWGGHTEVVSALLYAGV 581
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VD + +T L AA G E +V A ADNE RT + AA GH I+E
Sbjct: 582 KVDCADADSRTALRAAAWGGREDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEH 641
Query: 183 LADKFKASIFERTKDGSTLMHIASL-----NGHADCAMMLFKKG 221
L D A + DG T + +A+L GHA +L +G
Sbjct: 642 LLD-HGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRG 684
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/111 (32%), Positives = 50/111 (45%), Gaps = 1/111 (0%)
Query: 112 DMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLA 171
D R L+D GA V+ + G+T L AA G +V A+ I D TP+ LA
Sbjct: 472 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA 531
Query: 172 AENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGV 222
A GH ++ L A+I +DG T + A+ GH + L GV
Sbjct: 532 ARQGHTKVVNCLIG-CGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGV 581
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/132 (27%), Positives = 66/132 (50%), Gaps = 2/132 (1%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K DG +++ A + + L+ G +V+ + + TALH++ +V+ L+ Y
Sbjct: 888 KDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAY 947
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
ADV+ ++R + L AA K +L++ GA + G T + +AA+ G++
Sbjct: 948 HADVNAADNEKR-SALQSAA-WQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHID 1005
Query: 779 TLVLLLEDGGDP 790
+ +LLE G DP
Sbjct: 1006 VVQVLLEHGADP 1017
Score = 53.6 bits (123), Expect = 7e-06
Identities = 79/293 (26%), Positives = 120/293 (40%), Gaps = 35/293 (11%)
Query: 656 EKYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETL 715
E ++ G +H AA GH I L+++G + ND +A + V+ L
Sbjct: 786 ENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQIL 845
Query: 716 LGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
L +++ RG R L +AA D L L GA N DG +++ A
Sbjct: 846 LENKSNIDQRGYDGRNA-LRVAALEGHRDIVEL-LFSHGADVNCKDADGRPTLYILALEN 903
Query: 776 NLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESV 835
L LE+G + V D G T L ++C ++V+ LI + D
Sbjct: 904 QLTMAEYFLENGAN------VEASD-AEGRTALHVSCWQGHMEMVQVLIAYHAD------ 950
Query: 836 STAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFH 895
++A D + SAL A + VK VV+ LIE+GA V T + TA
Sbjct: 951 ----VNAADNEKRSALQSA--AWQGHVK-------VVQLLIEHGAVVD-HTCNQGATALC 996
Query: 896 YCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTL 948
A G+ DV+ ++ H AD N + G T + +A GH Q++ L
Sbjct: 997 IAAQEGHIDVVQVLLEH--GADP----NHADQFGRTAMRVAAKNGHSQIIKLL 1043
Score = 48.0 bits (109), Expect = 4e-04
Identities = 43/159 (27%), Positives = 66/159 (41%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L A +G+ +V L+S L+ G T L LAAR+ + L+ GA
Sbjct: 491 GRTLLANAAYSGSLDVVNLLVSR--GADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGA 548
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
++ T+ G T L AA G +V AD + RT + AA G I+
Sbjct: 549 NINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGREDIVLN 608
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L + A + + +G T + A+ GH + L G
Sbjct: 609 LL-QHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 646
>AK126888-1|BAC86737.1| 687|Homo sapiens protein ( Homo sapiens cDNA
FLJ44940 fis, clone BRAMY4000915, weakly similar to
Ankyrin 1. ).
Length = 687
Score = 196 bits (479), Expect = 5e-49
Identities = 157/486 (32%), Positives = 233/486 (47%), Gaps = 29/486 (5%)
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
+N Q++ TPL A + G +++ L+ + ARV+ D + + LH A + L
Sbjct: 67 VNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVL 126
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
L + A +N++ +N +T LH+AA N + L+ + ++V +T LH AA SG
Sbjct: 127 LKHSADVNARDKNWQTPLHIAAANKAVKCAEALV-PLLSNVNVSDRAGRTALHHAAFSGH 185
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAH 1101
E+ KLLL GANI+A D+ ++ IH AA + EVV+L L H V K T H
Sbjct: 186 GEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKL-LVSHGAEVTCKDKKSYTPLH 244
Query: 1102 IAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDE 1161
AA G + V++ L+ GV +TPL +A G VV L+ GA +
Sbjct: 245 AAASSGMISVVKYLLDL---GVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQK 301
Query: 1162 NRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK-KLGLTPLHIAAYYGQAETVRELLSH 1220
N G T +H AA H + + N ++ K K G TPLH+ A +G+
Sbjct: 302 NEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRF--------- 352
Query: 1221 VPGTVKSEAPTGVSLVPVLGAE--SGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNE- 1277
S + T + V+ E +G TPLH+AA G+E ++ L+ S AD A
Sbjct: 353 ------SRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSG---ADTAKRGI 403
Query: 1278 NGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGA 1337
+G PLHLA G LLS ++ + D G+T LH A+ G+ + + +LL GA
Sbjct: 404 HGMFPLHLAALSGFSDCCRKLLSSGFDI-DTPDDFGRTCLHAAAAGGNLECLNLLLNTGA 462
Query: 1338 EINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAA-SENHNDVLE 1396
+ N DK G +PLH AA + + L SGAS C P+ +AA S+ LE
Sbjct: 463 DFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLE 522
Query: 1397 YLLHKE 1402
YLL +
Sbjct: 523 YLLRND 528
Score = 176 bits (429), Expect = 6e-43
Identities = 187/661 (28%), Positives = 291/661 (44%), Gaps = 75/661 (11%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA G II L+ G V+ + T LH AV SC V+ LL + ADV+ R
Sbjct: 78 LHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNAR- 136
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
K +TPLHIAA KCA L+ + N + G T +H AA G+ + LLL
Sbjct: 137 DKNWQTPLHIAA-ANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSR 195
Query: 787 GGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDED 846
G + + +D + A ++V+ L+ H E + D+
Sbjct: 196 GAN------INAFD-KKDRRAIHWAAYMGHIEVVKLLV----SHGAE------VTCKDKK 238
Query: 847 GASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVM 906
+ LH A + VVK L++ G D++ + + T H G + V+
Sbjct: 239 SYTPLHAAAS---------SGMISVVKYLLDLGVDMNEPNAYGN-TPLHVACYNGQDVVV 288
Query: 907 TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQL-VNTLLTNHARVDVFDVEGRSA 965
E+I D +N++N G+TPL A H L + L+ N A V++ +G++
Sbjct: 289 NELI------DCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTP 342
Query: 966 LHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVL 1025
LH+ A HG ++ + A I+ + +NG T LH+AA G+ L+ LI A
Sbjct: 343 LHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITS-GADTAKR 401
Query: 1026 TLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQH 1085
+ PLHLAA SG + C+ LL G +ID D+ G+ +HAAA E + L L
Sbjct: 402 GIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTG 461
Query: 1086 PNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLND--STPLQLAAEGG 1143
+ K G + H AA + + + F G ++ N L++ TPL AA
Sbjct: 462 ADF-NKKDKFGRSPLHYAAANCNYQCL-----FALVGSGASVNDLDERGCTPLHYAATSD 515
Query: 1144 -HADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRS------------TNTL 1190
+ L+R A+ ++ G AVH +A +GH L ++ S T+ L
Sbjct: 516 TDGKCLEYLLRNDANPGVRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDML 575
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPV-LGAESGLTPLH 1249
S + ++PLH+AAY+G + + L+ SL+ + + SG TPL
Sbjct: 576 SDSDNRATISPLHLAAYHGHHQALEVLVQ--------------SLLDLDVRNSSGRTPLD 621
Query: 1250 LAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHST 1309
LAA+ G+ V +L+N G P+H A GH + LL+ +AE ++
Sbjct: 622 LAAFKGHVECVDVLINQ-GASILVKDYILKRTPIHAAATNGHSECLRLLIG-NAEPQNAV 679
Query: 1310 D 1310
D
Sbjct: 680 D 680
Score = 176 bits (428), Expect = 8e-43
Identities = 178/708 (25%), Positives = 315/708 (44%), Gaps = 54/708 (7%)
Query: 679 INTLLQKGESVDVTTNDN----YTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPL 734
I+ L Q+ +S+ + N Y +L A+ + P V L+ DV+ + ++R TPL
Sbjct: 20 ISKLPQENKSLHSPPSGNVLVRYPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKR-TPL 78
Query: 735 HIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKT 794
H AA + D + L++L SGA N +TP+H A + + +LL+ D +
Sbjct: 79 HAAAYLGDAEIIELLIL-SGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARD 137
Query: 795 KVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYA 854
K +TPL +A + L+ + + ++ D G +ALH+A
Sbjct: 138 K-------NWQTPLHIAAANKAVKCAEALVPLLSN----------VNVSDRAGRTALHHA 180
Query: 855 CKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHIS 914
+ ++VK L+ GA+++ + + A H+ A G+ +V+ +++H
Sbjct: 181 AF---------SGHGEMVKLLLSRGANINAFDKKDRR-AIHWAAYMGHIEVVKLLVSH-- 228
Query: 915 TADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGY 974
A+V+ ++ +TPL A G + +V LL ++ + G + LH+A +G
Sbjct: 229 GAEVTC----KDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQ 284
Query: 975 LQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH 1034
V + L+ A +N K G T LH AA + + L L+ + A +++ + +TPLH
Sbjct: 285 DVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLH 344
Query: 1035 LAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTK 1094
+ A G+ + +++ GA ID D+ G P+H AA+ + ++ + +
Sbjct: 345 MTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGI- 403
Query: 1095 DGNTCAHIAAIQGSVKVIEELMK--FDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
G H+AA+ G +L+ FD I + T L AA GG+ + + +L+
Sbjct: 404 HGMFPLHLAALSGFSDCCRKLLSSGFD----IDTPDDFG-RTCLHAAAAGGNLECLNLLL 458
Query: 1153 RAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAE 1212
GA +++ G + +H AA + + L + + + G TPLH AA
Sbjct: 459 NTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDG 518
Query: 1213 TVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGV-QA 1271
E L G + V A L L A +E + +L+ ++G
Sbjct: 519 KCLEYLLRNDANPGVRDKQGYNAVHYSAAYGHRLCLQLIA---SETPLDVLMETSGTDML 575
Query: 1272 DAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEV 1331
+ N +PLHLA + GH + +L+ + L + G+T L +A+ GH + V+V
Sbjct: 576 SDSDNRATISPLHLAAYHGHHQALEVLVQSLLD-LDVRNSSGRTPLDLAAFKGHVECVDV 634
Query: 1332 LLGQGAEINATDK-NGWTPLHCAAKAGHLNVVKLLCESGASPKSETNL 1378
L+ QGA I D TP+H AA GH ++LL A P++ ++
Sbjct: 635 LINQGASILVKDYILKRTPIHAAATNGHSECLRLLI-GNAEPQNAVDI 681
Score = 172 bits (419), Expect = 1e-41
Identities = 123/377 (32%), Positives = 175/377 (46%), Gaps = 19/377 (5%)
Query: 1028 KKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPN 1087
+K+TPLH AA G E+ +LL+ GA ++A D P+H A + E VQ+ L+ H
Sbjct: 73 EKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLK-HSA 131
Query: 1088 LVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADV 1147
V A K+ T HIAA +VK E L+ +S R T L AA GH ++
Sbjct: 132 DVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRA---GRTALHHAAFSGHGEM 188
Query: 1148 VRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAY 1207
V++L+ GA+ ++ A+H AA GH V+ ++ S K TPLH AA
Sbjct: 189 VKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAAS 248
Query: 1208 YGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSA 1267
G V+ LL V P G TPLH+A YNG + VV L++
Sbjct: 249 SGMISVVKYLLDL---GVDMNEPNAY----------GNTPLHVACYNGQDVVVNELIDCG 295
Query: 1268 GVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQ 1327
+ NE G+ PLH A H ++ LL + ++ + GKT LH+ + HG +
Sbjct: 296 AIVNQ--KNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFS 353
Query: 1328 MVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAA 1387
+ ++ GA I+ DKNG TPLH AA+ GH ++ L SGA P+ AA
Sbjct: 354 RSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAA 413
Query: 1388 SENHNDVLEYLLHKEHD 1404
+D LL D
Sbjct: 414 LSGFSDCCRKLLSSGFD 430
Score = 163 bits (397), Expect = 5e-39
Identities = 126/425 (29%), Positives = 200/425 (47%), Gaps = 20/425 (4%)
Query: 980 ALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAAS 1039
AL+ K +N + RT LH AA G A +++ LI A ++ K TPLH A AS
Sbjct: 59 ALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILS-GARVNAKDSKWLTPLHRAVAS 117
Query: 1040 GQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTC 1099
E ++LL+ A+++A D+ Q P+H AA N + + + N V + + G T
Sbjct: 118 CSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSN-VNVSDRAGRTA 176
Query: 1100 AHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
H AA G ++++ L+ R I+A +K D + AA GH +VV++LV GA T
Sbjct: 177 LHHAAFSGHGEMVKLLLS--RGANINAFDK-KDRRAIHWAAYMGHIEVVKLLVSHGAEVT 233
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
+++ T +H AA G +V+ + G TPLH+A Y GQ V EL+
Sbjct: 234 CKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELID 293
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G + ++ E G TPLH AA + + + LL G + S + G
Sbjct: 294 C--GAIVNQKN-----------EKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD-G 339
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
PLH+ G S ++ +S ++ D++G T LHIA+ +GH ++ L+ GA+
Sbjct: 340 KTPLHMTALHGRFSRSQTII-QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADT 398
Query: 1340 NATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+G PLH AA +G + + L SG + + + AA+ + + L LL
Sbjct: 399 AKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLL 458
Query: 1400 HKEHD 1404
+ D
Sbjct: 459 NTGAD 463
Score = 163 bits (396), Expect = 6e-39
Identities = 143/550 (26%), Positives = 248/550 (45%), Gaps = 38/550 (6%)
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALN 923
+ + + V+ L+++ ADV+ + + N +T H A ++ +S +VS
Sbjct: 115 VASCSEEAVQVLLKHSADVNARDK-NWQTPLHIAAANKAVKCAEALVPLLSNVNVS---- 169
Query: 924 RQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLT 983
+ G T L A GH ++V LL+ A ++ FD + R A+H AA G+++V L++
Sbjct: 170 --DRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVS 227
Query: 984 NKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIE 1043
+ A + K + T LH AA +G +VK+L+ D ++ TPLH+A +GQ
Sbjct: 228 HGAEVTCKDKKSYTPLHAAASSGMISVVKYLL-DLGVDMNEPNAYGNTPLHVACYNGQDV 286
Query: 1044 VCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIA 1103
V L++ GA ++ +E G P+H AA + + + L + V +KDG T H+
Sbjct: 287 VVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMT 346
Query: 1104 AIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENR 1163
A+ G + +++ VI +K N +TPL +AA GH ++ L+ +GA
Sbjct: 347 ALHGRFSRSQTIIQSG--AVIDCEDK-NGNTPLHIAARYGHELLINTLITSGADTAKRGI 403
Query: 1164 AGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPG 1223
G+ +HLAA G ++ + S+ + G T LH AA G E + LL+
Sbjct: 404 HGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD 463
Query: 1224 TVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPL 1283
K + + G +PLH AA N N + L+ S D +E G PL
Sbjct: 464 FNKKD-------------KFGRSPLHYAAANCNYQCLFALVGSGASVNDL--DERGCTPL 508
Query: 1284 HLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQ-------- 1335
H A L R+ D+ G +H ++ +GH ++++ +
Sbjct: 509 HYAATSDTDGKCLEYLLRNDANPGVRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLME 568
Query: 1336 --GAEINATDKNGWT--PLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENH 1391
G ++ + N T PLH AA GH +++L +S + P+ AA + H
Sbjct: 569 TSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGH 628
Query: 1392 NDVLEYLLHK 1401
+ ++ L+++
Sbjct: 629 VECVDVLINQ 638
Score = 132 bits (320), Expect = 1e-29
Identities = 138/502 (27%), Positives = 230/502 (45%), Gaps = 53/502 (10%)
Query: 665 RSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHI 724
R+IH AA GH+ ++ L+ G V +YT LH A S +VV+ LL G D++
Sbjct: 208 RAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN- 266
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA-TLVLL 783
TPLH+A D L+ GA N+ E G TP+H AA + A L LL
Sbjct: 267 EPNAYGNTPLHVAC-YNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELL 325
Query: 784 LEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAV 843
+ +G D K+K G+TPL M + +I+ S A ID
Sbjct: 326 VGNGADVNMKSK-------DGKTPLHMTALHGRFSRSQTIIQ----------SGAVIDCE 368
Query: 844 DEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN 903
D++G + LH A + E ++ LI +GAD + + H H A++G +
Sbjct: 369 DKNGNTPLHIAARYGHE---------LLINTLITSGADTAKRGIHG-MFPLHLAALSGFS 418
Query: 904 DVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGR 963
D ++++ S D+ + + G T L A G+++ +N LL A + D GR
Sbjct: 419 DCCRKLLS--SGFDI----DTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGR 472
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY-AHLVKFLIRDHNAMI 1022
S LH AA + Q AL+ + A +N G T LH AA + +++L+R ++A
Sbjct: 473 SPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLR-NDANP 531
Query: 1023 DVLTLKKQTPLHLAAASG-----QIEVCKLLLELGANIDATDELGQ-------KPIHAAA 1070
V + +H +AA G Q+ + L++ TD L P+H AA
Sbjct: 532 GVRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAA 591
Query: 1071 QNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKL 1130
+ + + +++ +Q +L + + G T +AA +G V+ ++ L+ ++ I ++ +
Sbjct: 592 YHGHHQALEVLVQSLLDLDVRNS-SGRTPLDLAAFKGHVECVDVLI--NQGASILVKDYI 648
Query: 1131 NDSTPLQLAAEGGHADVVRVLV 1152
TP+ AA GH++ +R+L+
Sbjct: 649 LKRTPIHAAATNGHSECLRLLI 670
Score = 132 bits (318), Expect = 2e-29
Identities = 110/372 (29%), Positives = 174/372 (46%), Gaps = 23/372 (6%)
Query: 1036 AAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKD 1095
A +G + + L+ +++ D + P+HAAA +E+++L + V A
Sbjct: 48 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGAR-VNAKDSK 106
Query: 1096 GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAG 1155
T H A S + ++ L+K + ++AR+K N TPL +AA LV
Sbjct: 107 WLTPLHRAVASCSEEAVQVLLK--HSADVNARDK-NWQTPLHIAAANKAVKCAEALVPLL 163
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
++ +RAG TA+H AA GH ++ ++ S + K +H AAY G E V+
Sbjct: 164 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 223
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS 1275
L+SH + + TPLH AA +G +VV+ LL+ GV +
Sbjct: 224 LLVSHGAEVTCKD-------------KKSYTPLHAAASSGMISVVKYLLD-LGVDMNEP- 268
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIA--STHGHYQMVEVLL 1333
N G PLH+AC+ G +V L+ A +++ + G T LH A STHG +E+L+
Sbjct: 269 NAYGNTPLHVACYNGQDVVVNELIDCGA-IVNQKNEKGFTPLHFAAASTHGAL-CLELLV 326
Query: 1334 GQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHND 1393
G GA++N K+G TPLH A G + + + +SGA E P+ AA H
Sbjct: 327 GNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHEL 386
Query: 1394 VLEYLLHKEHDT 1405
++ L+ DT
Sbjct: 387 LINTLITSGADT 398
Score = 122 bits (295), Expect = 1e-26
Identities = 128/450 (28%), Positives = 207/450 (46%), Gaps = 51/450 (11%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAV-VETLLGYGAD 721
G +H A G ++N L+ G V+ +T LH A S A+ +E L+G GAD
Sbjct: 272 GNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGAD 331
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V+++ K +TPLH+ A + + +++SGA + ++G TP+H+AA++G+ +
Sbjct: 332 VNMKS-KDGKTPLHMTA-LHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLIN 389
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
L+ G D ++ + G PL +A S D R L+ D ID
Sbjct: 390 TLITSGADTAKRG-------IHGMFPLHLAALSGFSDCCRKLLSSGFD----------ID 432
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
D+ G + LH A + + + L+ GAD + + + + HY A
Sbjct: 433 TPDDFGRTCLHAAAA---------GGNLECLNLLLNTGADFNKKDKFGR-SPLHYAAANC 482
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRG-HMQLVNTLLTNHARVDVFDV 960
N + ++ S A V N + G TPL A + + LL N A V D
Sbjct: 483 NYQCLFALVG--SGASV----NDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGVRDK 536
Query: 961 EGRSALHLAAEHGY---LQVC------DALL-TNKAFINSKARNGRTA--LHLAAMNGYA 1008
+G +A+H +A +G+ LQ+ D L+ T+ + S + N T LHLAA +G+
Sbjct: 537 QGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHH 596
Query: 1009 HLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDE-LGQKPIH 1067
++ L++ +DV +TPL LAA G +E +L+ GA+I D L + PIH
Sbjct: 597 QALEVLVQSL-LDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIH 655
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGN 1097
AAA N +SE ++L + +DGN
Sbjct: 656 AAATNGHSECLRLLIGNAEPQNAVDIQDGN 685
Score = 119 bits (287), Expect = 1e-25
Identities = 107/364 (29%), Positives = 163/364 (44%), Gaps = 35/364 (9%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K DG +H A +G T++Q G +D + T LHIA ++ TL+
Sbjct: 335 KSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITS 394
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
GAD R G PLH+AA D C LL SG + + G T +H AA GNL
Sbjct: 395 GADTAKR-GIHGMFPLHLAALSGFSD-CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLE 452
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
L LLL G D +K K G +PL A +C + L+ S A
Sbjct: 453 CLNLLLNTGADFNKKDKF-------GRSPLHYAAANCNYQCLFALVG----------SGA 495
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
++ +DE G + LHYA T + D + ++ L+ N A+ ++ + + A HY A
Sbjct: 496 SVNDLDERGCTPLHYA--ATSD------TDGKCLEYLLRNDANPGVRDKQGY-NAVHYSA 546
Query: 899 IAGNNDVM------TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
G+ + T + + T+ + N +PL +A + GH Q + L+ +
Sbjct: 547 AYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSL 606
Query: 953 ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKAR-NGRTALHLAAMNGYAHLV 1011
+DV + GR+ L LAA G+++ D L+ A I K RT +H AA NG++ +
Sbjct: 607 LDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECL 666
Query: 1012 KFLI 1015
+ LI
Sbjct: 667 RLLI 670
Score = 105 bits (251), Expect = 2e-21
Identities = 88/325 (27%), Positives = 146/325 (44%), Gaps = 20/325 (6%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
TPL AA G A+++ +L+ +GA ++ LT +H A + V+ + +
Sbjct: 76 TPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNA 135
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAY 1253
K TPLHIAA + L+ + S+ +G T LH AA+
Sbjct: 136 RDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSD-------------RAGRTALHHAAF 182
Query: 1254 NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHG 1313
+G+ +V+LLL S G +A ++ +H A + GH+ +V LL+S AE+ D+
Sbjct: 183 SGHGEMVKLLL-SRGANINAFDKKDR-RAIHWAAYMGHIEVVKLLVSHGAEVT-CKDKKS 239
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPK 1373
T LH A++ G +V+ LL G ++N + G TPLH A G VV L + GA
Sbjct: 240 YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 299
Query: 1374 SETNLNCAPIWFAASENHNDV-LEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEE 1432
+ P+ FAA+ H + LE L+ D D + ++ H +
Sbjct: 300 QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTAL---HGRFSRSQ 356
Query: 1433 FVLVSPAPVDTAAKLSNIYINLSTK 1457
++ S A +D K N ++++ +
Sbjct: 357 TIIQSGAVIDCEDKNGNTPLHIAAR 381
Score = 72.5 bits (170), Expect = 1e-11
Identities = 52/165 (31%), Positives = 79/165 (47%), Gaps = 3/165 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL AV + ++ V+ LL + + + A T LH+AA + V A LV + V+
Sbjct: 110 PLHRAVASCSEEAVQVLL--KHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVN 167
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
++ AG+T LH AA G +VK AN D +DR +H AA GH +++LL
Sbjct: 168 VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLV- 226
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
A + + K T +H A+ +G L GV ++ PN Y
Sbjct: 227 SHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAY 271
Score = 71.7 bits (168), Expect = 3e-11
Identities = 49/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L A +G+ MV+ LLS + A A+H AA +++ ++LV +GA
Sbjct: 173 GRTALHHAAFSGHGEMVKLLLSR--GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA 230
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V + TPLH AA+ G +VKY + + + TP+H+A NG ++
Sbjct: 231 EVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNE 290
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGH-ADCAMMLFKKGVYLHMPNK 229
L D A + ++ + G T +H A+ + H A C +L G ++M +K
Sbjct: 291 LID-CGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSK 337
Score = 70.1 bits (164), Expect = 8e-11
Identities = 49/171 (28%), Positives = 80/171 (46%), Gaps = 4/171 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL A + + ++ ELL A+ + + G T LH+ A ++ ++
Sbjct: 303 EKGFTPLHFAAASTHGALCLELLVGNGAD-VNMKSKDGKTPLHMTALHGRFSRSQTIIQS 361
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA-AI 179
GAV+D + G TPLHIAA G E L+ A+ A P+HLAA +G +
Sbjct: 362 GAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCC 421
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
+LL+ F I G T +H A+ G+ +C +L G + +K+
Sbjct: 422 RKLLSSGF--DIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKF 470
Score = 67.3 bits (157), Expect = 6e-10
Identities = 38/131 (29%), Positives = 65/131 (49%), Gaps = 2/131 (1%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T LH AA + + + L+D G ++ N G TPLH+A G + +V A
Sbjct: 241 TPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQ 300
Query: 160 ADNEDRTPMHLAAENGHAAI-IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF 218
+ + TP+H AA + H A+ +ELL A + ++KDG T +H+ +L+G + +
Sbjct: 301 KNEKGFTPLHFAAASTHGALCLELLVGN-GADVNMKSKDGKTPLHMTALHGRFSRSQTII 359
Query: 219 KKGVYLHMPNK 229
+ G + +K
Sbjct: 360 QSGAVIDCEDK 370
Score = 63.7 bits (148), Expect = 7e-09
Identities = 58/216 (26%), Positives = 101/216 (46%), Gaps = 16/216 (7%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL A G+ ++ ELL A ++ A T LH A + ++L+ + A
Sbjct: 75 RTPLHAAAYLGDAEII-ELLILSGA-RVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSAD 132
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
V+A + QTPLHIAAA + + +N ++D RT +H AA +GH +++LL
Sbjct: 133 VNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLL 192
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDEVLFVK 243
+ A+I K +H A+ GH + +L G + +K+++ L
Sbjct: 193 LSR-GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK----DKKSYTP-LHAA 246
Query: 244 IENGLIKGLKSDDGSYSMFLGIPYALVNESNPFGDS 279
+G+I +K Y + LG+ +NE N +G++
Sbjct: 247 ASSGMISVVK-----YLLDLGVD---MNEPNAYGNT 274
Score = 52.4 bits (120), Expect = 2e-05
Identities = 42/146 (28%), Positives = 68/146 (46%), Gaps = 3/146 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A G++ ++ L+++ A+ K G LHLAA D R L+
Sbjct: 370 KNGNTPLHIAARYGHELLINTLITSG-ADTAKRGIH-GMFPLHLAALSGFSDCCRKLLSS 427
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G +D + G+T LH AAA G+ + A+ D R+P+H AA N + +
Sbjct: 428 GFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCL 487
Query: 181 ELLADKFKASIFERTKDGSTLMHIAS 206
L AS+ + + G T +H A+
Sbjct: 488 FALVGS-GASVNDLDERGCTPLHYAA 512
Score = 52.0 bits (119), Expect = 2e-05
Identities = 30/116 (25%), Positives = 56/116 (48%)
Query: 102 LHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIAD 161
L L A +D+ + D+ N A +PLH+AA G ++ + + +
Sbjct: 554 LQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRN 613
Query: 162 NEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+ RTP+ LAA GH +++L ++ + + + T +H A+ NGH++C +L
Sbjct: 614 SSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLL 669
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/110 (31%), Positives = 53/110 (48%), Gaps = 5/110 (4%)
Query: 110 DVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTP 167
D D R L+ V+ + +TPLH AA GD +++ G R NA D++ TP
Sbjct: 53 DPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNA--KDSKWLTP 110
Query: 168 MHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+H A + +++L K A + R K+ T +HIA+ N CA L
Sbjct: 111 LHRAVASCSEEAVQVLL-KHSADVNARDKNWQTPLHIAAANKAVKCAEAL 159
Score = 46.0 bits (104), Expect = 0.001
Identities = 31/109 (28%), Positives = 51/109 (46%), Gaps = 1/109 (0%)
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
Y L A F G V L+ + ++ + D +T LH A+ G +++E+L+ GA +
Sbjct: 42 YPSLVQAIFNGDPDEVRALIFKKEDV-NFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 100
Query: 1340 NATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAAS 1388
NA D TPLH A + V++L + A + P+ AA+
Sbjct: 101 NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAA 149
Score = 42.7 bits (96), Expect = 0.014
Identities = 23/80 (28%), Positives = 43/80 (53%), Gaps = 5/80 (6%)
Query: 159 IADNEDR---TPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAM 215
++D+++R +P+HLAA +GH +E+L + R G T + +A+ GH +C
Sbjct: 575 LSDSDNRATISPLHLAAYHGHHQALEVLVQSL-LDLDVRNSSGRTPLDLAAFKGHVECVD 633
Query: 216 MLFKKGVYLHMPNKYFEKQT 235
+L +G + + Y K+T
Sbjct: 634 VLINQGASI-LVKDYILKRT 652
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/102 (25%), Positives = 46/102 (45%), Gaps = 2/102 (1%)
Query: 1323 HGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAP 1382
+G V L+ + ++N D TPLH AA G +++LL SGA ++ + P
Sbjct: 51 NGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTP 110
Query: 1383 IWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKN 1424
+ A + + ++ LL +H DK + L + + N
Sbjct: 111 LHRAVASCSEEAVQVLL--KHSADVNARDKNWQTPLHIAAAN 150
Score = 35.9 bits (79), Expect = 1.6
Identities = 20/46 (43%), Positives = 24/46 (52%)
Query: 138 AAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
A GD V+ + + DNE RTP+H AA G A IIELL
Sbjct: 48 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELL 93
>AB209308-1|BAD92545.1| 931|Homo sapiens ankyrin 3 isoform 1 variant
protein.
Length = 931
Score = 184 bits (448), Expect = 3e-45
Identities = 131/419 (31%), Positives = 210/419 (50%), Gaps = 26/419 (6%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G T L +A G ++V L+ + A+V+ + ++ LH++A G + LL A
Sbjct: 10 GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASP 69
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N+ +G T LHL+A G+ + FL+ DH A + + T K TPLH+AA G++EV LL
Sbjct: 70 NAATTSGYTPLHLSAREGHEDVAAFLL-DHGASLSITTKKGFTPLHVAAKYGKLEVANLL 128
Query: 1049 LELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGS 1108
L+ A+ DA + G P+H AA + +V L L Q + A K+G T HIAA +
Sbjct: 129 LQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGAS-PHAAAKNGYTPLHIAAKKNQ 187
Query: 1109 VKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTA 1168
+ + L+++ R + + LAA+ GH D+V +L+ A+ N++GLT
Sbjct: 188 MDIATTLLEYGADANAVTRQGI---ASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTP 244
Query: 1169 VHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSE 1228
+HLAA+ NV +V+ + + K+G TPLH+ +YG + V LL H + K
Sbjct: 245 LHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQH---SAKVN 301
Query: 1229 APTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNE---NGYNPLHL 1285
A T ++G TPLH AA G+ +++ +LL Q +A+ NE NG L +
Sbjct: 302 AKT----------KNGYTPLHQAAQQGHTHIINVLL-----QNNASPNELTVNGNTALGI 346
Query: 1286 ACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDK 1344
A G++S+V L + E + +T K +++ T + G+ A TDK
Sbjct: 347 ARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPETMNEVLDMSDDEGEDAMTGDTDK 405
Score = 181 bits (441), Expect = 2e-44
Identities = 122/373 (32%), Positives = 193/373 (51%), Gaps = 21/373 (5%)
Query: 993 RNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELG 1052
+ G TALH+AA +G A +V++L++D A ++ QTPLH++A G+ ++ + LL+ G
Sbjct: 8 QRGETALHMAARSGQAEVVRYLVQD-GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQG 66
Query: 1053 ANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVI 1112
A+ +A G P+H +A+ + +V FL H + TTK G T H+AA G ++V
Sbjct: 67 ASPNAATTSGYTPLHLSAREGHEDVAA-FLLDHGASLSITTKKGFTPLHVAAKYGKLEVA 125
Query: 1113 EELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA 1172
L++ + + ++ L TPL +AA + V +L+ GAS + G T +H+A
Sbjct: 126 NLLLQKSASPDAAGKSGL---TPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIA 182
Query: 1173 AEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
A+ ++ + + + G+ +H+AA G + V LL G
Sbjct: 183 AKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL-------------G 229
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHM 1292
+ L +SGLTPLHLAA NV +L+N G DA + + GY PLH+ C G++
Sbjct: 230 RNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQ-GAHVDAQT-KMGYTPLHVGCHYGNI 287
Query: 1293 SIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHC 1352
IV LL SA++ T ++G T LH A+ GH ++ VLL A N NG T L
Sbjct: 288 KIVNFLLQHSAKVNAKT-KNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGI 346
Query: 1353 AAKAGHLNVVKLL 1365
A + G+++VV L
Sbjct: 347 ARRLGYISVVDTL 359
Score = 173 bits (422), Expect = 4e-42
Identities = 109/305 (35%), Positives = 166/305 (54%), Gaps = 21/305 (6%)
Query: 1096 GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAG 1155
G T H+AA G +V+ L++ + A+ K +D TPL ++A G AD+V+ L++ G
Sbjct: 10 GETALHMAARSGQAEVVRYLVQDGAQ--VEAKAK-DDQTPLHISARLGKADIVQQLLQQG 66
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTN-TLRISSKKLGLTPLHIAAYYGQAETV 1214
AS +G T +HL+A GH +V + +L I++KK G TPLH+AA YG+ E
Sbjct: 67 ASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKK-GFTPLHVAAKYGKLEVA 125
Query: 1215 RELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAA 1274
LL KS +P +SGLTPLH+AA+ N+ V LLL+ G AA
Sbjct: 126 NLLLQ------KSASPDAAG-------KSGLTPLHVAAHYDNQKVALLLLDQ-GASPHAA 171
Query: 1275 SNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG 1334
+ +NGY PLH+A M I LL A+ ++ R G +H+A+ GH MV +LLG
Sbjct: 172 A-KNGYTPLHIAAKKNQMDIATTLLEYGADA-NAVTRQGIASVHLAAQEGHVDMVSLLLG 229
Query: 1335 QGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDV 1394
+ A +N ++K+G TPLH AA+ +NV ++L GA ++T + P+ + +
Sbjct: 230 RNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKI 289
Query: 1395 LEYLL 1399
+ +LL
Sbjct: 290 VNFLL 294
Score = 172 bits (418), Expect = 1e-41
Identities = 117/348 (33%), Positives = 187/348 (53%), Gaps = 22/348 (6%)
Query: 1030 QTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
+T LH+AA SGQ EV + L++ GA ++A + Q P+H +A+ +++VQ LQQ +
Sbjct: 11 ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPN 70
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVR 1149
ATT G T H++A +G V L+ D +S K TPL +AA+ G +V
Sbjct: 71 AATTS-GYTPLHLSAREGHEDVAAFLL--DHGASLSITTK-KGFTPLHVAAKYGKLEVAN 126
Query: 1150 VLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYG 1209
+L++ AS ++GLT +H+AA + + V ++ ++ K G TPLHIAA
Sbjct: 127 LLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKN 186
Query: 1210 QAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLN-SAG 1268
Q + LL + G V G+ +HLAA G+ ++V LLL +A
Sbjct: 187 QMDIATTLLEY-----------GADANAV--TRQGIASVHLAAQEGHVDMVSLLLGRNAN 233
Query: 1269 VQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQM 1328
V SN++G PLHLA +++ +L+++ A + T + G T LH+ +G+ ++
Sbjct: 234 VNL---SNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT-KMGYTPLHVGCHYGNIKI 289
Query: 1329 VEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSET 1376
V LL A++NA KNG+TPLH AA+ GH +++ +L ++ ASP T
Sbjct: 290 VNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELT 337
Score = 171 bits (417), Expect = 2e-41
Identities = 110/347 (31%), Positives = 176/347 (50%), Gaps = 20/347 (5%)
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
G+ +H AA++ +EVV+ +L Q V A KD T HI+A G ++++L++
Sbjct: 10 GETALHMAARSGQAEVVR-YLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQ---Q 65
Query: 1122 GVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVL 1181
G + TPL L+A GH DV L+ GAS + + G T +H+AA++G V
Sbjct: 66 GASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVA 125
Query: 1182 DVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGA 1241
+++ + ++ K GLTPLH+AA+Y + LL G S P A
Sbjct: 126 NLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ-----------GAS--PHAAA 172
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
++G TPLH+AA ++ LL G A+A + + G +HLA GH+ +V LLL R
Sbjct: 173 KNGYTPLHIAAKKNQMDIATTLLEY-GADANAVTRQ-GIASVHLAAQEGHVDMVSLLLGR 230
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNV 1361
+A + + +++ G T LH+A+ + EVL+ QGA ++A K G+TPLH G++ +
Sbjct: 231 NANV-NLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKI 289
Query: 1362 VKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
V L + A ++T P+ AA + H ++ LL L
Sbjct: 290 VNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNEL 336
Score = 149 bits (361), Expect = 1e-34
Identities = 118/386 (30%), Positives = 183/386 (47%), Gaps = 36/386 (9%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H AAR G ++ L+Q G V+ D+ T LHI+ K +V+ LL GA
Sbjct: 10 GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASP 69
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ TPLH++AR D A LL GA + T+ G TP+HVAAK+G L L
Sbjct: 70 NA-ATTSGYTPLHLSAREGHEDVAAF-LLDHGASLSITTKKGFTPLHVAAKYGKLEVANL 127
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL+ P K +G TPL +A + L++ +G S A
Sbjct: 128 LLQKSASPDAAGK-------SGLTPLHVAAHYDNQKVALLLLD-----QGASPHAAA--- 172
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
++G + LH A K K ++ I T L+E GAD + TR + H A G+
Sbjct: 173 --KNGYTPLHIAAK--KNQMDIATT-------LLEYGADANAVTRQGIASV-HLAAQEGH 220
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
D+++ ++ + ++S N G TPL +A + + L+ A VD G
Sbjct: 221 VDMVSLLLGRNANVNLS------NKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMG 274
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+ LH+ +G +++ + LL + A +N+K +NG T LH AA G+ H++ L++ +NA
Sbjct: 275 YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQ-NNASP 333
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLL 1048
+ LT+ T L +A G I V L
Sbjct: 334 NELTVNGNTALGIARRLGYISVVDTL 359
Score = 148 bits (359), Expect = 2e-34
Identities = 111/353 (31%), Positives = 168/353 (47%), Gaps = 35/353 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
D +H +AR G I+ LLQ+G S + T YT LH++ V LL +GA
Sbjct: 42 DDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGAS 101
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ I K+ TPLH+AA+ + L+L KS A P+ A + G+TP+HVAA + N +
Sbjct: 102 LSITT-KKGFTPLHVAAKYGKLEVANLLLQKS-ASPDAAGKSGLTPLHVAAHYDNQKVAL 159
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LLL+ G P K G TPL +A + DI L+E+ D +
Sbjct: 160 LLLDQGASPHAAAK-------NGYTPLHIAAKKNQMDIATTLLEYGAD----------AN 202
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
AV G +++H A +E + +V L+ A+V+L + T H A
Sbjct: 203 AVTRQGIASVHLAA----QEGHV-----DMVSLLLGRNANVNLSNKSGL-TPLHLAAQED 252
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+V ++ + D Q +G+TPL + CH G++++VN LL + A+V+
Sbjct: 253 RVNVAEVLVNQGAHVDA------QTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKN 306
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
G + LH AA+ G+ + + LL N A N NG TAL +A GY +V L
Sbjct: 307 GYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 359
Score = 128 bits (309), Expect = 2e-28
Identities = 88/283 (31%), Positives = 143/283 (50%), Gaps = 19/283 (6%)
Query: 1165 GLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGT 1224
G TA+H+AA G V+ + + K TPLHI+A G+A+ V++LL
Sbjct: 10 GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ---- 65
Query: 1225 VKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLH 1284
G S P SG TPLHL+A G+E+V LL+ + + + + G+ PLH
Sbjct: 66 -------GAS--PNAATTSGYTPLHLSAREGHEDVAAFLLDHGA--SLSITTKKGFTPLH 114
Query: 1285 LACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDK 1344
+A G + + LLL +SA + + G T LH+A+ + + ++ +LL QGA +A K
Sbjct: 115 VAAKYGKLEVANLLLQKSASP-DAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAK 173
Query: 1345 NGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
NG+TPLH AAK +++ L E GA + T A + AA E H D++ LL + +
Sbjct: 174 NGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNAN 233
Query: 1405 TQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKL 1447
+ +K + L + ++ + + + E ++ A VD K+
Sbjct: 234 VN--LSNKSGLTPLHLAAQ-EDRVNVAEVLVNQGAHVDAQTKM 273
Score = 87.4 bits (207), Expect = 5e-16
Identities = 54/169 (31%), Positives = 86/169 (50%), Gaps = 3/169 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
QRG+ L +A +G +VR L+ Q Q++A T LH++AR D+ + L+
Sbjct: 8 QRGETALHMAARSGQAEVVRYLV--QDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ 65
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA +A +G TPLH++A EG E + + A+ +I + TP+H+AA+ G +
Sbjct: 66 GASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVA 125
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
LL K AS K G T +H+A+ + A++L +G H K
Sbjct: 126 NLLLQK-SASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAK 173
Score = 81.0 bits (191), Expect = 4e-14
Identities = 50/173 (28%), Positives = 82/173 (47%), Gaps = 3/173 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D + G PL +A NQ + LL + A G T LH+AA++ +D+A
Sbjct: 136 DAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKN--GYTPLHIAAKKNQMDIATT 193
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L++YGA +A G +H+AA EG +V G AN +++ TP+HLAA+
Sbjct: 194 LLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDR 253
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+ E+L ++ A + +TK G T +H+ G+ L + ++ K
Sbjct: 254 VNVAEVLVNQ-GAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTK 305
Score = 79.0 bits (186), Expect = 2e-13
Identities = 46/142 (32%), Positives = 73/142 (51%), Gaps = 4/142 (2%)
Query: 1305 LLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKL 1364
L H R G+T LH+A+ G ++V L+ GA++ A K+ TPLH +A+ G ++V+
Sbjct: 3 LAHVPQR-GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQ 61
Query: 1365 LCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKN 1424
L + GASP + T P+ +A E H DV +LL +H + K+ L V +K
Sbjct: 62 LLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLL--DHGASLSITTKKGFTPLHVAAK- 118
Query: 1425 HNNIPIEEFVLVSPAPVDTAAK 1446
+ + + +L A D A K
Sbjct: 119 YGKLEVANLLLQKSASPDAAGK 140
Score = 78.6 bits (185), Expect = 2e-13
Identities = 53/152 (34%), Positives = 76/152 (50%), Gaps = 3/152 (1%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++G + LA + G+ MV LL L + +G T LHLAA+ V++A +LV
Sbjct: 204 VTRQGIASVHLAAQEGHVDMVSLLLGRNANVNL--SNKSGLTPLHLAAQEDRVNVAEVLV 261
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
+ GA VDA G TPLH+ G+ +V + A TP+H AA+ GH
Sbjct: 262 NQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTH 321
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGH 210
II +L AS E T +G+T + IA G+
Sbjct: 322 IINVLLQN-NASPNELTVNGNTALGIARRLGY 352
Score = 77.0 bits (181), Expect = 7e-13
Identities = 48/167 (28%), Positives = 80/167 (47%), Gaps = 3/167 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL L+ G++ + LL + L TT G T LH+AA+ +++A +L+ A
Sbjct: 76 GYTPLHLSAREGHEDVAAFLLDHGAS--LSITTKKGFTPLHVAAKYGKLEVANLLLQKSA 133
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
DA +G TPLH+AA ++ + A+ A TP+H+AA+ I
Sbjct: 134 SPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATT 193
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L + + A T+ G +H+A+ GH D +L + +++ NK
Sbjct: 194 LLE-YGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNK 239
Score = 71.3 bits (167), Expect = 3e-11
Identities = 45/159 (28%), Positives = 74/159 (46%), Gaps = 3/159 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL +A + + LL + A T G ++HLAA+ VDM +L+
Sbjct: 173 KNGYTPLHIAAKKNQMDIATTLL--EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGR 230
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A V+ +N +G TPLH+AA E + + A+ TP+H+ G+ I+
Sbjct: 231 NANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIV 290
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
L + A + +TK+G T +H A+ GH +L +
Sbjct: 291 NFLL-QHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 328
Score = 46.4 bits (105), Expect = 0.001
Identities = 33/121 (27%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL LA + + V E+L Q A + A T G T LH+ ++ + L+ + A
Sbjct: 241 GLTPLHLAAQEDRVN-VAEVLVNQGAH-VDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSA 298
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+A G TPLH AA +G ++ A+ T + +A G+ ++++
Sbjct: 299 KVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDT 358
Query: 183 L 183
L
Sbjct: 359 L 359
>BC016985-1|AAH16985.2| 579|Homo sapiens ANKRD44 protein protein.
Length = 579
Score = 184 bits (447), Expect = 4e-45
Identities = 135/468 (28%), Positives = 225/468 (48%), Gaps = 20/468 (4%)
Query: 932 PLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSK 991
PL+ A G + + L+ V+ D E R+ LH+AA G ++ + L+ + A +N+K
Sbjct: 11 PLVQAIFSGDPEEIRMLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAK 70
Query: 992 ARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLEL 1051
T LH A + V+ LI+ H+A ++ QTPLH+AAA+ ++ ++++ L
Sbjct: 71 DNMWLTPLHRAVASRSEEAVQVLIK-HSADVNARDKNWQTPLHVAAANKAVKCAEVIIPL 129
Query: 1052 GANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKV 1111
++++ +D G+ +H AA N + E+V L L + N+ KD H AA G + V
Sbjct: 130 LSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKD-RRALHWAAYMGHLDV 188
Query: 1112 IEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHL 1171
+ L+ + ++ ++K TPL AA G +VV+ L+ G + N G TA+H+
Sbjct: 189 VALLI--NHGAEVTCKDK-KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHI 245
Query: 1172 AAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT 1231
A +G V++ + G TPLH AA ELL V + A
Sbjct: 246 ACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELL------VNNGADV 299
Query: 1232 GVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGH 1291
+ ++ G +PLH+ A +G + L+ + G + D +++G PLH+A GH
Sbjct: 300 NIQ------SKDGKSPLHMTAVHGRFTRSQTLIQNGG-EIDCV-DKDGNTPLHVAARYGH 351
Query: 1292 MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLH 1351
++ L++ A+ H LH+A+ + H LL G EI+ DK G T LH
Sbjct: 352 ELLINTLITSGADTA-KCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLH 410
Query: 1352 CAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
AA G++ +KLL SGA + P+ +AA+ H +E L+
Sbjct: 411 AAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLV 458
Score = 182 bits (443), Expect = 1e-44
Identities = 145/495 (29%), Positives = 239/495 (48%), Gaps = 27/495 (5%)
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
+N +S TPL +A G +++ L+ + ARV+ D + LH A + L
Sbjct: 34 VNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVL 93
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
+ + A +N++ +N +T LH+AA N + +I ++ ++V +T LH AA +G
Sbjct: 94 IKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSS-VNVSDRGGRTALHHAALNGH 152
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAH 1101
+E+ LLL GANI+A D+ ++ +H AA + +VV L + H V K G T H
Sbjct: 153 VEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN-HGAEVTCKDKKGYTPLH 211
Query: 1102 IAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDE 1161
AA G + V++ L+ GV + +T L +A G VV L+ GA+
Sbjct: 212 AAASNGQINVVKHLLNL---GVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQP 268
Query: 1162 NRAGLTAVHLAAEHGHTNV-LDVMRSTNT-LRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
N G T +H AA H + L+++ + + I SK G +PLH+ A +G+ + L+
Sbjct: 269 NNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKD-GKSPLHMTAVHGRFTRSQTLIQ 327
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS-NEN 1278
+ G + V + G TPLH+AA G+E ++ L+ S AD A +
Sbjct: 328 N-----------GGEIDCV--DKDGNTPLHVAARYGHELLINTLITSG---ADTAKCGIH 371
Query: 1279 GYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAE 1338
PLHLA H LLS E+ + D+ G+T LH A+ G+ + +++L GA+
Sbjct: 372 SMFPLHLAALNAHSDCCRKLLSSGFEI-DTPDKFGRTCLHAAAAGGNVECIKLLQSSGAD 430
Query: 1339 INATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYL 1398
+ DK G TPLH AA H + ++ L +GA+ + + +AA+ + D + +
Sbjct: 431 FHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASD-MDRNKTI 489
Query: 1399 LHKEHDTQSLMDDKR 1413
L HD ++ R
Sbjct: 490 LGNAHDNSEELERAR 504
Score = 148 bits (359), Expect = 2e-34
Identities = 153/547 (27%), Positives = 246/547 (44%), Gaps = 69/547 (12%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA G II L+ G V+ N T LH AV S V+ L+ + ADV+ R
Sbjct: 45 LHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARD 104
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
K +TPLH+AA KCA +++ + N + G T +H AA G++ + LLL
Sbjct: 105 -KNWQTPLHVAAA-NKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAK 162
Query: 787 GGDPL---RKTKVCIY--------DVVT---------------GETPLQMACRSCMPDIV 820
G + +K + ++ DVV G TPL A + ++V
Sbjct: 163 GANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVV 222
Query: 821 RHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGA 880
+HL+ + ID ++ G +ALH AC ++ V V LI+ GA
Sbjct: 223 KHLLNLGVE----------IDEINVYGNTALHIACYNGQDAV---------VNELIDYGA 263
Query: 881 DVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRG 940
+V+ Q +N T H+ A + + + E++ + + ADV N Q+ G +PL + G
Sbjct: 264 NVN-QPNNNGFTPLHFAAASTHGALCLELLVN-NGADV----NIQSKDGKSPLHMTAVHG 317
Query: 941 HMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALH 1000
TL+ N +D D +G + LH+AA +G+ + + L+T+ A + LH
Sbjct: 318 RFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLITSGADTAKCGIHSMFPLH 377
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDE 1060
LAA+N ++ + L+ ID +T LH AAA G +E KLL GA+ D+
Sbjct: 378 LAALNAHSDCCRKLLSS-GFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDK 436
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDR 1120
G+ P+H AA N + ++ + N V T G T H AA DR
Sbjct: 437 CGRTPLHYAAANCHFHCIETLVTTGAN-VNETDDWGRTALHYAAASD----------MDR 485
Query: 1121 TGVISARNKLNDSTPLQLAAEGGHADV---VRVLVRAGASCTDENRAGLTAVHLAAEHGH 1177
I N ++S L+ A E + + L++ A+ + ++ G ++H AA +GH
Sbjct: 486 NKTILG-NAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGH 544
Query: 1178 TNVLDVM 1184
L+++
Sbjct: 545 RQCLELV 551
Score = 143 bits (346), Expect = 7e-33
Identities = 126/504 (25%), Positives = 227/504 (45%), Gaps = 39/504 (7%)
Query: 703 AVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATE 762
A+ S P + L+ DV+ ++R TPLH+AA + D + L++L SGA N
Sbjct: 15 AIFSGDPEEIRMLIHKTEDVNTLDSEKR-TPLHVAAFLGDAEIIELLIL-SGARVNAKDN 72
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
+TP+H A + + +L++ D + K +TPL +A +
Sbjct: 73 MWLTPLHRAVASRSEEAVQVLIKHSADVNARDK-------NWQTPLHVAAANKAVKCAEV 125
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
+I + ++ D G +ALH+A ++V L+ GA++
Sbjct: 126 IIPLLSS----------VNVSDRGGRTALHHAAL---------NGHVEMVNLLLAKGANI 166
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ + + A H+ A G+ DV+ +I H A+V+ ++ G+TPL A G +
Sbjct: 167 NAFDKKDRR-ALHWAAYMGHLDVVALLINH--GAEVTC----KDKKGYTPLHAAASNGQI 219
Query: 943 QLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLA 1002
+V LL +D +V G +ALH+A +G V + L+ A +N NG T LH A
Sbjct: 220 NVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFA 279
Query: 1003 AMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELG 1062
A + + L L+ ++ A +++ + ++PLH+ A G+ + L++ G ID D+ G
Sbjct: 280 AASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDG 339
Query: 1063 QKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTG 1122
P+H AA+ + ++ + + H+AA+ +L+
Sbjct: 340 NTPLHVAARYGHELLINTLITSGADTAKCGI-HSMFPLHLAALNAHSDCCRKLLSSGFE- 397
Query: 1123 VISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLD 1182
I +K T L AA GG+ + +++L +GA +++ G T +H AA + H + ++
Sbjct: 398 -IDTPDKFG-RTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIE 455
Query: 1183 VMRSTNTLRISSKKLGLTPLHIAA 1206
+ +T + G T LH AA
Sbjct: 456 TLVTTGANVNETDDWGRTALHYAA 479
Score = 140 bits (340), Expect = 4e-32
Identities = 114/384 (29%), Positives = 179/384 (46%), Gaps = 23/384 (5%)
Query: 1024 VLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
VL L Q PL A SG E ++L+ +++ D + P+H AA +E+++L +
Sbjct: 3 VLKLTDQPPLVQAIFSGDPEEIRMLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLIL 62
Query: 1084 QHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGG 1143
V A T H A S + ++ L+K + ++AR+K N TPL +AA
Sbjct: 63 SGAR-VNAKDNMWLTPLHRAVASRSEEAVQVLIK--HSADVNARDK-NWQTPLHVAAANK 118
Query: 1144 HADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLH 1203
V++ +S +R G TA+H AA +GH +++++ + + K LH
Sbjct: 119 AVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALH 178
Query: 1204 IAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLL 1263
AAY G + V L++H + + G TPLH AA NG NVV+ L
Sbjct: 179 WAAYMGHLDVVALLINHGAEVTCKD-------------KKGYTPLHAAASNGQINVVKHL 225
Query: 1264 LNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIA--S 1321
LN GV+ D N G LH+AC+ G ++V L+ A + + + +G T LH A S
Sbjct: 226 LN-LGVEIDEI-NVYGNTALHIACYNGQDAVVNELIDYGANV-NQPNNNGFTPLHFAAAS 282
Query: 1322 THGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCA 1381
THG +E+L+ GA++N K+G +PLH A G + L ++G
Sbjct: 283 THGAL-CLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNT 341
Query: 1382 PIWFAASENHNDVLEYLLHKEHDT 1405
P+ AA H ++ L+ DT
Sbjct: 342 PLHVAARYGHELLINTLITSGADT 365
Score = 136 bits (329), Expect = 8e-31
Identities = 140/496 (28%), Positives = 226/496 (45%), Gaps = 41/496 (8%)
Query: 679 INTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAA 738
I L+ K E V+ ++ T LH+A ++E L+ GA V+ + TPLH A
Sbjct: 24 IRMLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWL-TPLHRAV 82
Query: 739 RIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCI 798
++ +L+K A N ++ TP+HVAA + +++ PL + V +
Sbjct: 83 -ASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVII-----PL-LSSVNV 135
Query: 799 YDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVT 858
D G T L A + ++V L+ KG A I+A D+ ALH+A +
Sbjct: 136 SD-RGGRTALHHAALNGHVEMVNLLLA-----KG-----ANINAFDKKDRRALHWAAYM- 183
Query: 859 KEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADV 918
VV LI +GA+V+ + + + T H A A N + ++ H+ V
Sbjct: 184 --------GHLDVVALLINHGAEVTCKDKKGY-TPLH--AAASNGQI--NVVKHLLNLGV 230
Query: 919 SRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVC 978
++ N G T L IAC+ G +VN L+ A V+ + G + LH AA + +C
Sbjct: 231 E--IDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALC 288
Query: 979 -DALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAA 1037
+ L+ N A +N ++++G++ LH+ A++G + LI+ + ID + TPLH+AA
Sbjct: 289 LELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQ-NGGEIDCVDKDGNTPLHVAA 347
Query: 1038 ASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGN 1097
G + L+ GA+ P+H AA N +S+ + L + K G
Sbjct: 348 RYGHELLINTLITSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFE-IDTPDKFGR 406
Query: 1098 TCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGAS 1157
TC H AA G+V+ I+ L +G + TPL AA H + LV GA+
Sbjct: 407 TCLHAAAAGGNVECIKLLQS---SGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGAN 463
Query: 1158 CTDENRAGLTAVHLAA 1173
+ + G TA+H AA
Sbjct: 464 VNETDDWGRTALHYAA 479
Score = 97.5 bits (232), Expect = 5e-19
Identities = 88/308 (28%), Positives = 134/308 (43%), Gaps = 34/308 (11%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA G + ++ LL G +D TALHIA + + AVV L+ YGA+V
Sbjct: 206 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 265
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + TPLH AA G C +L+ +GA N ++DG +P+H+ A G
Sbjct: 266 N-QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQT 324
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
L+++GG+ + D G TPL +A R ++ LI D + + F
Sbjct: 325 LIQNGGE------IDCVD-KDGNTPLHVAARYGHELLINTLITSGADTAKCGIHSMF--- 374
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
LH A A + L+ +G ++ + T H A GN
Sbjct: 375 -------PLHLAAL---------NAHSDCCRKLLSSGFEIDTPDKFG-RTCLHAAAAGGN 417
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
+ + + S AD ++++ G TPL A H + TL+T A V+ D G
Sbjct: 418 VECI--KLLQSSGAD----FHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWG 471
Query: 963 RSALHLAA 970
R+ALH AA
Sbjct: 472 RTALHYAA 479
Score = 96.7 bits (230), Expect = 8e-19
Identities = 120/452 (26%), Positives = 195/452 (43%), Gaps = 43/452 (9%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H AA GHV ++N LL KG +++ + ALH A VV L+ +GA+V
Sbjct: 140 GRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEV 199
Query: 723 HIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ K+ TPLH AA +G LL G ++ G T +H+A G A +
Sbjct: 200 TCK-DKKGYTPLHAAA--SNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVN 256
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
L++ G + + G TPL A S + L+ + G A ++
Sbjct: 257 ELIDYGANVNQPNN-------NGFTPLHFAAASTHGALCLELLV----NNG-----ADVN 300
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
+DG S LH +T + + + LI+NG ++ + + T H A G
Sbjct: 301 IQSKDGKSPLH----MTAVHGRFTRS-----QTLIQNGGEIDCVDKDGN-TPLHVAARYG 350
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ ++ +I S AD ++ PL +A H LL++ +D D
Sbjct: 351 HELLINTLIT--SGADTAKC----GIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKF 404
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM 1021
GR+ LH AA G ++ L ++ A + K + GRT LH AA N + H ++ L+ A
Sbjct: 405 GRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTT-GAN 463
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
++ +T LH AAAS ++ K + LG D ++EL + + + ++
Sbjct: 464 VNETDDWGRTALHYAAAS-DMDRNKTI--LGNAHDNSEEL--ERARELKEKEATLCLEFL 518
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIE 1113
LQ N K+G H AA G + +E
Sbjct: 519 LQNDAN-PSIRDKEGYNSIHYAAAYGHRQCLE 549
Score = 77.4 bits (182), Expect = 5e-13
Identities = 61/193 (31%), Positives = 85/193 (44%), Gaps = 19/193 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DG +H A +G TL+Q G +D D T LH+A ++ TL+ GAD
Sbjct: 305 DGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLITSGAD 364
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ G PLH+AA D C LL SG + + G T +H AA GN+ +
Sbjct: 365 T-AKCGIHSMFPLHLAALNAHSD-CCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIK 422
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LL G D +K K C G TPL A +C + L+ + A ++
Sbjct: 423 LLQSSGADFHKKDK-C------GRTPLHYAAANCHFHCIETLV----------TTGANVN 465
Query: 842 AVDEDGASALHYA 854
D+ G +ALHYA
Sbjct: 466 ETDDWGRTALHYA 478
Score = 70.5 bits (165), Expect = 6e-11
Identities = 49/168 (29%), Positives = 77/168 (45%), Gaps = 4/168 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL A + + ++ ELL A+ + + G + LH+ A ++ L+ G
Sbjct: 272 GFTPLHFAAASTHGALCLELLVNNGAD-VNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGG 330
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA-AIIE 181
+D + G TPLH+AA G E L+ A+ A P+HLAA N H+ +
Sbjct: 331 EIDCVDKDGNTPLHVAARYGHELLINTLITSGADTAKCGIHSMFPLHLAALNAHSDCCRK 390
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
LL+ F+ I K G T +H A+ G+ +C +L G H +K
Sbjct: 391 LLSSGFE--IDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDK 436
Score = 69.7 bits (163), Expect = 1e-10
Identities = 48/165 (29%), Positives = 78/165 (47%), Gaps = 3/165 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL AV + ++ V+ L+ + + + A T LH+AA + V A +++ + V+
Sbjct: 77 PLHRAVASRSEEAVQVLI--KHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVN 134
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
++ G+T LH AA G +V AN D +DR +H AA GH ++ LL +
Sbjct: 135 VSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 194
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
A + + K G T +H A+ NG + L GV + N Y
Sbjct: 195 H-GAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVY 238
Score = 69.7 bits (163), Expect = 1e-10
Identities = 48/168 (28%), Positives = 81/168 (48%), Gaps = 4/168 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L A G+ MV LL+ + A ALH AA +D+ +L+++GA
Sbjct: 140 GRTALHHAALNGHVEMVNLLLAK--GANINAFDKKDRRALHWAAYMGHLDVVALLINHGA 197
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V + G TPLH AA+ G +VK+ + + T +H+A NG A++
Sbjct: 198 EVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNE 257
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGH-ADCAMMLFKKGVYLHMPNK 229
L D + A++ + +G T +H A+ + H A C +L G +++ +K
Sbjct: 258 LID-YGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSK 304
Score = 68.9 bits (161), Expect = 2e-10
Identities = 49/166 (29%), Positives = 79/166 (47%), Gaps = 3/166 (1%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL +A G+ ++ ELL A ++ A T LH A R + ++L+ + A
Sbjct: 42 RTPLHVAAFLGDAEII-ELLILSGA-RVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSAD 99
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
V+A + QTPLH+AAA + + ++ ++D RT +H AA NGH ++ LL
Sbjct: 100 VNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLL 159
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
K A+I K +H A+ GH D +L G + +K
Sbjct: 160 LAK-GANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 204
Score = 68.9 bits (161), Expect = 2e-10
Identities = 39/125 (31%), Positives = 65/125 (52%), Gaps = 2/125 (1%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G T LH AA +++ + L++ G +D N G T LHIA G + +V AN
Sbjct: 206 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 265
Query: 158 AIADNEDRTPMHLAAENGHAAI-IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMM 216
+N TP+H AA + H A+ +ELL + A + ++KDG + +H+ +++G +
Sbjct: 266 NQPNNNGFTPLHFAAASTHGALCLELLVNN-GADVNIQSKDGKSPLHMTAVHGRFTRSQT 324
Query: 217 LFKKG 221
L + G
Sbjct: 325 LIQNG 329
Score = 65.7 bits (153), Expect = 2e-09
Identities = 49/173 (28%), Positives = 74/173 (42%), Gaps = 12/173 (6%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMA-RILVDYG 121
G L +A G ++V EL+ + G T LH AA + +LV+ G
Sbjct: 239 GNTALHIACYNGQDAVVNELIDY--GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNG 296
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE 181
A V+ + G++PLH+ A G + D + TP+H+AA GH +I
Sbjct: 297 ADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLIN 356
Query: 182 LL----ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
L AD K I +H+A+LN H+DC L G + P+K+
Sbjct: 357 TLITSGADTAKCGIHSMFP-----LHLAALNAHSDCCRKLLSSGFEIDTPDKF 404
Score = 64.1 bits (149), Expect = 5e-09
Identities = 46/160 (28%), Positives = 70/160 (43%), Gaps = 1/160 (0%)
Query: 69 LAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATN 128
L V A N+++ + + + G TALH AA V+M +L+ GA ++A +
Sbjct: 111 LHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFD 170
Query: 129 GAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFK 188
+ LH AA G +V A D + TP+H AA NG +++ L +
Sbjct: 171 KKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLN-LG 229
Query: 189 ASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
I E G+T +HIA NG L G ++ PN
Sbjct: 230 VEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 269
Score = 62.9 bits (146), Expect = 1e-08
Identities = 48/150 (32%), Positives = 71/150 (47%), Gaps = 3/150 (2%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D V + G PL +A G++ ++ L+++ A+ K + LHLAA D R
Sbjct: 333 DCVDKDGNTPLHVAARYGHELLINTLITSG-ADTAKCGIHSM-FPLHLAALNAHSDCCRK 390
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+ G +D + G+T LH AAA G+ +K A+ D RTP+H AA N H
Sbjct: 391 LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCH 450
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIAS 206
IE L A++ E G T +H A+
Sbjct: 451 FHCIETLVTT-GANVNETDDWGRTALHYAA 479
Score = 54.0 bits (124), Expect = 5e-06
Identities = 43/159 (27%), Positives = 62/159 (38%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
GK PL + G + + L+ Q ++ G+T LH+AAR + L+ GA
Sbjct: 306 GKSPLHMTAVHGRFTRSQTLI--QNGGEIDCVDKDGNTPLHVAARYGHELLINTLITSGA 363
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
PLH+AA + D RT +H AA G+ I+L
Sbjct: 364 DTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKL 423
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L A ++ K G T +H A+ N H C L G
Sbjct: 424 LQSS-GADFHKKDKCGRTPLHYAAANCHFHCIETLVTTG 461
Score = 51.2 bits (117), Expect = 4e-05
Identities = 33/110 (30%), Positives = 55/110 (50%), Gaps = 5/110 (4%)
Query: 110 DVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTP 167
D + R+L+ V+ + +TPLH+AA GD +++ G R NA DN TP
Sbjct: 20 DPEEIRMLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNA--KDNMWLTP 77
Query: 168 MHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+H A + +++L K A + R K+ T +H+A+ N CA ++
Sbjct: 78 LHRAVASRSEEAVQVLI-KHSADVNARDKNWQTPLHVAAANKAVKCAEVI 126
Score = 44.4 bits (100), Expect = 0.004
Identities = 26/101 (25%), Positives = 48/101 (47%), Gaps = 2/101 (1%)
Query: 1324 GHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPI 1383
G + + +L+ + ++N D TPLH AA G +++LL SGA ++ N+ P+
Sbjct: 19 GDPEEIRMLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPL 78
Query: 1384 WFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKN 1424
A + + ++ L+ +H DK + L V + N
Sbjct: 79 HRAVASRSEEAVQVLI--KHSADVNARDKNWQTPLHVAAAN 117
Score = 44.0 bits (99), Expect = 0.006
Identities = 47/151 (31%), Positives = 61/151 (40%), Gaps = 8/151 (5%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L A GN ++ LL + A+ K G T LH AA LV GA
Sbjct: 405 GRTCLHAAAAGGNVECIK-LLQSSGADFHKKDK-CGRTPLHYAAANCHFHCIETLVTTGA 462
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+ T+ G+T LH AAA D K G NA E L + + L
Sbjct: 463 NVNETDDWGRTALHYAAA-SDMDRNKTILG---NAHDNSEELERARELKEKEATLCLEFL 518
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADC 213
L + SI R K+G +H A+ GH C
Sbjct: 519 LQNDANPSI--RDKEGYNSIHYAAAYGHRQC 547
Score = 42.3 bits (95), Expect = 0.018
Identities = 35/121 (28%), Positives = 54/121 (44%), Gaps = 7/121 (5%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA H I TL+ G +V+ T + TALH A S +T+LG D
Sbjct: 438 GRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDR-NKTILGNAHDN 496
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ RE + + C LL++ A P+ ++G +H AA +G+ L L
Sbjct: 497 SEELERARE------LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLEL 550
Query: 783 L 783
+
Sbjct: 551 V 551
Score = 36.7 bits (81), Expect = 0.89
Identities = 21/52 (40%), Positives = 27/52 (51%)
Query: 132 QTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
Q PL A GD ++ + D+E RTP+H+AA G A IIELL
Sbjct: 9 QPPLVQAIFSGDPEEIRMLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELL 60
>AC013264-1|AAX93155.1| 525|Homo sapiens unknown protein.
Length = 525
Score = 182 bits (443), Expect = 1e-44
Identities = 145/495 (29%), Positives = 237/495 (47%), Gaps = 27/495 (5%)
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
+N +S TPL +A G +++ L+ + ARV+ D + LH A + L
Sbjct: 9 VNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVL 68
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
+ + A +N++ +N +T LH+AA N + +I + ++V +T LH AA +G
Sbjct: 69 IKHSADVNARDKNWQTPLHVAAANKAVKCAEVII-PLLSSVNVSDRGGRTALHHAALNGH 127
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAH 1101
+E+ LLL GANI+A D+ ++ +H AA + +VV L + H V K G T H
Sbjct: 128 VEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLI-NHGAEVTCKDKKGYTPLH 186
Query: 1102 IAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDE 1161
AA G + V++ L+ GV + +T L +A G VV L+ GA+
Sbjct: 187 AAASNGQINVVKHLLNL---GVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQP 243
Query: 1162 NRAGLTAVHLAA--EHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
N G T +H AA HG + ++ + + I SK G +PLH+ A +G+ + L+
Sbjct: 244 NNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKD-GKSPLHMTAVHGRFTRSQTLIQ 302
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS-NEN 1278
+ G + V + G TPLH+AA G+E ++ L+ S AD A +
Sbjct: 303 N-----------GGEIDCV--DKDGNTPLHVAARYGHELLINTLITSG---ADTAKCGIH 346
Query: 1279 GYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAE 1338
PLHLA H LLS E + + D+ G+T LH A+ G+ + +++L GA+
Sbjct: 347 SMFPLHLAALNAHSDCCRKLLSSGFE-IDTPDKFGRTCLHAAAAGGNVECIKLLQSSGAD 405
Query: 1339 INATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYL 1398
+ DK G TPLH AA H + ++ L +GA+ + + +AA+ + D + +
Sbjct: 406 FHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASD-MDRNKTI 464
Query: 1399 LHKEHDTQSLMDDKR 1413
L HD ++ R
Sbjct: 465 LGNAHDNSEELERAR 479
Score = 148 bits (358), Expect = 2e-34
Identities = 153/546 (28%), Positives = 245/546 (44%), Gaps = 69/546 (12%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA G II L+ G V+ N T LH AV S V+ L+ + ADV+ R
Sbjct: 20 LHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARD 79
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
K +TPLH+AA KCA +++ + N + G T +H AA G++ + LLL
Sbjct: 80 -KNWQTPLHVAAA-NKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAK 137
Query: 787 GGDPL---RKTKVCIY--------DVVT---------------GETPLQMACRSCMPDIV 820
G + +K + ++ DVV G TPL A + ++V
Sbjct: 138 GANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVV 197
Query: 821 RHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGA 880
+HL+ + ID ++ G +ALH AC ++ V V LI+ GA
Sbjct: 198 KHLLNLGVE----------IDEINVYGNTALHIACYNGQDAV---------VNELIDYGA 238
Query: 881 DVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRG 940
+V+ Q +N T H+ A + + + E++ + + ADV N Q+ G +PL + G
Sbjct: 239 NVN-QPNNNGFTPLHFAAASTHGALCLELLVN-NGADV----NIQSKDGKSPLHMTAVHG 292
Query: 941 HMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALH 1000
TL+ N +D D +G + LH+AA +G+ + + L+T+ A + LH
Sbjct: 293 RFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLITSGADTAKCGIHSMFPLH 352
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDE 1060
LAA+N ++ + L+ ID +T LH AAA G +E KLL GA+ D+
Sbjct: 353 LAALNAHSDCCRKLLSS-GFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDK 411
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDR 1120
G+ P+H AA N + ++ + N V T G T H AA DR
Sbjct: 412 CGRTPLHYAAANCHFHCIETLVTTGAN-VNETDDWGRTALHYAAASD----------MDR 460
Query: 1121 TGVISARNKLNDSTPLQLAAEGGHADV---VRVLVRAGASCTDENRAGLTAVHLAAEHGH 1177
I N ++S L+ A E + + L++ A+ + ++ G ++H AA +GH
Sbjct: 461 NKTILG-NAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGH 519
Query: 1178 TNVLDV 1183
L++
Sbjct: 520 RQCLEL 525
Score = 142 bits (344), Expect = 1e-32
Identities = 131/462 (28%), Positives = 214/462 (46%), Gaps = 45/462 (9%)
Query: 749 MLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPL 808
ML+ N + TP+HVAA G+ + LL+ G K + + TPL
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWL-------TPL 53
Query: 809 QMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTAD 868
A S + V+ LI+ D ++A D++ + LH A A
Sbjct: 54 HRAVASRSEEAVQVLIKHSAD----------VNARDKNWQTPLHVA------------AA 91
Query: 869 RQVVKC---LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQ 925
+ VKC +I + V++ R TA H+ A+ G+ +++ ++A + + +R+
Sbjct: 92 NKAVKCAEVIIPLLSSVNVSDR-GGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRR 150
Query: 926 NSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNK 985
++ W A + GH+ +V L+ + A V D +G + LH AA +G + V LL
Sbjct: 151 -ALHW-----AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLG 204
Query: 986 AFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVC 1045
I+ G TALH+A NG +V LI D+ A ++ TPLH AAAS +C
Sbjct: 205 VEIDEINVYGNTALHIACYNGQDAVVNELI-DYGANVNQPNNNGFTPLHFAAASTHGALC 263
Query: 1046 -KLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
+LL+ GA+++ + G+ P+H A + Q + Q+ + KDGNT H+AA
Sbjct: 264 LELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLI-QNGGEIDCVDKDGNTPLHVAA 322
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
G +I L+ +G +A+ ++ PL LAA H+D R L+ +G ++
Sbjct: 323 RYGHELLINTLI---TSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKF 379
Query: 1165 GLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
G T +H AA G+ + +++S+ K G TPLH AA
Sbjct: 380 GRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAA 421
Score = 140 bits (338), Expect = 6e-32
Identities = 119/478 (24%), Positives = 216/478 (45%), Gaps = 38/478 (7%)
Query: 729 QRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGG 788
++ TPLH+AA + D + L++L SGA N +TP+H A + + +L++
Sbjct: 15 EKRTPLHVAAFLGDAEIIELLIL-SGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSA 73
Query: 789 DPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGA 848
D + K +TPL +A + +I + ++ D G
Sbjct: 74 DVNARDK-------NWQTPLHVAAANKAVKCAEVIIPLLSS----------VNVSDRGGR 116
Query: 849 SALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTE 908
+ALH+A ++V L+ GA+++ + + A H+ A G+ DV+
Sbjct: 117 TALHHAAL---------NGHVEMVNLLLAKGANINAFDKKDRR-ALHWAAYMGHLDVVAL 166
Query: 909 MIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHL 968
+I H A+V+ ++ G+TPL A G + +V LL +D +V G +ALH+
Sbjct: 167 LINH--GAEVTC----KDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHI 220
Query: 969 AAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLK 1028
A +G V + L+ A +N NG T LH AA + + L L+ ++ A +++ +
Sbjct: 221 ACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKD 280
Query: 1029 KQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNL 1088
++PLH+ A G+ + L++ G ID D+ G P+H AA+ + ++ + +
Sbjct: 281 GKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLITSGADT 340
Query: 1089 VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVV 1148
H+AA+ +L+ I +K T L AA GG+ + +
Sbjct: 341 AKCGI-HSMFPLHLAALNAHSDCCRKLLSSGFE--IDTPDKFG-RTCLHAAAAGGNVECI 396
Query: 1149 RVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
++L +GA +++ G T +H AA + H + ++ + +T + G T LH AA
Sbjct: 397 KLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA 454
Score = 135 bits (326), Expect = 2e-30
Identities = 139/493 (28%), Positives = 225/493 (45%), Gaps = 41/493 (8%)
Query: 682 LLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIP 741
L+ K E V+ ++ T LH+A ++E L+ GA V+ + TPLH A
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWL-TPLHRAV-AS 59
Query: 742 DGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDV 801
++ +L+K A N ++ TP+HVAA + +++ PL + V + D
Sbjct: 60 RSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVII-----PL-LSSVNVSD- 112
Query: 802 VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEE 861
G T L A + ++V L+ KG A I+A D+ ALH+A +
Sbjct: 113 RGGRTALHHAALNGHVEMVNLLLA-----KG-----ANINAFDKKDRRALHWAAYM---- 158
Query: 862 VKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRA 921
VV LI +GA+V+ + + + T H A A N + ++ H+ V
Sbjct: 159 -----GHLDVVALLINHGAEVTCKDKKGY-TPLH--AAASNGQI--NVVKHLLNLGVE-- 206
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVC-DA 980
++ N G T L IAC+ G +VN L+ A V+ + G + LH AA + +C +
Sbjct: 207 IDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLEL 266
Query: 981 LLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASG 1040
L+ N A +N ++++G++ LH+ A++G + LI+ + ID + TPLH+AA G
Sbjct: 267 LVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQ-NGGEIDCVDKDGNTPLHVAARYG 325
Query: 1041 QIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCA 1100
+ L+ GA+ P+H AA N +S+ + L + K G TC
Sbjct: 326 HELLINTLITSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFE-IDTPDKFGRTCL 384
Query: 1101 HIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTD 1160
H AA G+V+ I+ L +G + TPL AA H + LV GA+ +
Sbjct: 385 HAAAAGGNVECIKLLQS---SGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNE 441
Query: 1161 ENRAGLTAVHLAA 1173
+ G TA+H AA
Sbjct: 442 TDDWGRTALHYAA 454
Score = 97.5 bits (232), Expect = 5e-19
Identities = 88/308 (28%), Positives = 134/308 (43%), Gaps = 34/308 (11%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA G + ++ LL G +D TALHIA + + AVV L+ YGA+V
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + TPLH AA G C +L+ +GA N ++DG +P+H+ A G
Sbjct: 241 N-QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQT 299
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
L+++GG+ + D G TPL +A R ++ LI D + + F
Sbjct: 300 LIQNGGE------IDCVD-KDGNTPLHVAARYGHELLINTLITSGADTAKCGIHSMF--- 349
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
LH A A + L+ +G ++ + T H A GN
Sbjct: 350 -------PLHLAAL---------NAHSDCCRKLLSSGFEIDTPDKFG-RTCLHAAAAGGN 392
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
+ + + S AD ++++ G TPL A H + TL+T A V+ D G
Sbjct: 393 VECI--KLLQSSGAD----FHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWG 446
Query: 963 RSALHLAA 970
R+ALH AA
Sbjct: 447 RTALHYAA 454
Score = 96.7 bits (230), Expect = 8e-19
Identities = 120/452 (26%), Positives = 195/452 (43%), Gaps = 43/452 (9%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H AA GHV ++N LL KG +++ + ALH A VV L+ +GA+V
Sbjct: 115 GRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEV 174
Query: 723 HIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ K+ TPLH AA +G LL G ++ G T +H+A G A +
Sbjct: 175 TCK-DKKGYTPLHAAA--SNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVN 231
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
L++ G + + G TPL A S + L+ + G A ++
Sbjct: 232 ELIDYGANVNQPNN-------NGFTPLHFAAASTHGALCLELLV----NNG-----ADVN 275
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
+DG S LH +T + + + LI+NG ++ + + T H A G
Sbjct: 276 IQSKDGKSPLH----MTAVHGRFTRS-----QTLIQNGGEIDCVDKDGN-TPLHVAARYG 325
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ ++ +I S AD ++ PL +A H LL++ +D D
Sbjct: 326 HELLINTLIT--SGADTAKC----GIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKF 379
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM 1021
GR+ LH AA G ++ L ++ A + K + GRT LH AA N + H ++ L+ A
Sbjct: 380 GRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTT-GAN 438
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
++ +T LH AAAS ++ K + LG D ++EL + + + ++
Sbjct: 439 VNETDDWGRTALHYAAAS-DMDRNKTI--LGNAHDNSEEL--ERARELKEKEATLCLEFL 493
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIE 1113
LQ N K+G H AA G + +E
Sbjct: 494 LQNDAN-PSIRDKEGYNSIHYAAAYGHRQCLE 524
Score = 77.4 bits (182), Expect = 5e-13
Identities = 61/193 (31%), Positives = 85/193 (44%), Gaps = 19/193 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DG +H A +G TL+Q G +D D T LH+A ++ TL+ GAD
Sbjct: 280 DGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLITSGAD 339
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ G PLH+AA D C LL SG + + G T +H AA GN+ +
Sbjct: 340 T-AKCGIHSMFPLHLAALNAHSD-CCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIK 397
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LL G D +K K C G TPL A +C + L+ + A ++
Sbjct: 398 LLQSSGADFHKKDK-C------GRTPLHYAAANCHFHCIETLV----------TTGANVN 440
Query: 842 AVDEDGASALHYA 854
D+ G +ALHYA
Sbjct: 441 ETDDWGRTALHYA 453
Score = 70.5 bits (165), Expect = 6e-11
Identities = 49/168 (29%), Positives = 77/168 (45%), Gaps = 4/168 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL A + + ++ ELL A+ + + G + LH+ A ++ L+ G
Sbjct: 247 GFTPLHFAAASTHGALCLELLVNNGAD-VNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGG 305
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA-AIIE 181
+D + G TPLH+AA G E L+ A+ A P+HLAA N H+ +
Sbjct: 306 EIDCVDKDGNTPLHVAARYGHELLINTLITSGADTAKCGIHSMFPLHLAALNAHSDCCRK 365
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
LL+ F+ I K G T +H A+ G+ +C +L G H +K
Sbjct: 366 LLSSGFE--IDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDK 411
Score = 69.7 bits (163), Expect = 1e-10
Identities = 48/165 (29%), Positives = 78/165 (47%), Gaps = 3/165 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL AV + ++ V+ L+ + + + A T LH+AA + V A +++ + V+
Sbjct: 52 PLHRAVASRSEEAVQVLI--KHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVN 109
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
++ G+T LH AA G +V AN D +DR +H AA GH ++ LL +
Sbjct: 110 VSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
A + + K G T +H A+ NG + L GV + N Y
Sbjct: 170 H-GAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVY 213
Score = 69.7 bits (163), Expect = 1e-10
Identities = 48/168 (28%), Positives = 81/168 (48%), Gaps = 4/168 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L A G+ MV LL+ + A ALH AA +D+ +L+++GA
Sbjct: 115 GRTALHHAALNGHVEMVNLLLAK--GANINAFDKKDRRALHWAAYMGHLDVVALLINHGA 172
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V + G TPLH AA+ G +VK+ + + T +H+A NG A++
Sbjct: 173 EVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNE 232
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGH-ADCAMMLFKKGVYLHMPNK 229
L D + A++ + +G T +H A+ + H A C +L G +++ +K
Sbjct: 233 LID-YGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSK 279
Score = 68.9 bits (161), Expect = 2e-10
Identities = 49/166 (29%), Positives = 79/166 (47%), Gaps = 3/166 (1%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL +A G+ ++ ELL A ++ A T LH A R + ++L+ + A
Sbjct: 17 RTPLHVAAFLGDAEII-ELLILSGA-RVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSAD 74
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
V+A + QTPLH+AAA + + ++ ++D RT +H AA NGH ++ LL
Sbjct: 75 VNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLL 134
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
K A+I K +H A+ GH D +L G + +K
Sbjct: 135 LAK-GANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
Score = 68.9 bits (161), Expect = 2e-10
Identities = 39/125 (31%), Positives = 65/125 (52%), Gaps = 2/125 (1%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G T LH AA +++ + L++ G +D N G T LHIA G + +V AN
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
Query: 158 AIADNEDRTPMHLAAENGHAAI-IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMM 216
+N TP+H AA + H A+ +ELL + A + ++KDG + +H+ +++G +
Sbjct: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNN-GADVNIQSKDGKSPLHMTAVHGRFTRSQT 299
Query: 217 LFKKG 221
L + G
Sbjct: 300 LIQNG 304
Score = 65.7 bits (153), Expect = 2e-09
Identities = 49/173 (28%), Positives = 74/173 (42%), Gaps = 12/173 (6%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMA-RILVDYG 121
G L +A G ++V EL+ + G T LH AA + +LV+ G
Sbjct: 214 GNTALHIACYNGQDAVVNELIDY--GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNG 271
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE 181
A V+ + G++PLH+ A G + D + TP+H+AA GH +I
Sbjct: 272 ADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLIN 331
Query: 182 LL----ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
L AD K I +H+A+LN H+DC L G + P+K+
Sbjct: 332 TLITSGADTAKCGIHSMFP-----LHLAALNAHSDCCRKLLSSGFEIDTPDKF 379
Score = 64.1 bits (149), Expect = 5e-09
Identities = 46/160 (28%), Positives = 70/160 (43%), Gaps = 1/160 (0%)
Query: 69 LAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATN 128
L V A N+++ + + + G TALH AA V+M +L+ GA ++A +
Sbjct: 86 LHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFD 145
Query: 129 GAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFK 188
+ LH AA G +V A D + TP+H AA NG +++ L +
Sbjct: 146 KKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLN-LG 204
Query: 189 ASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
I E G+T +HIA NG L G ++ PN
Sbjct: 205 VEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 244
Score = 62.9 bits (146), Expect = 1e-08
Identities = 48/150 (32%), Positives = 71/150 (47%), Gaps = 3/150 (2%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D V + G PL +A G++ ++ L+++ A+ K + LHLAA D R
Sbjct: 308 DCVDKDGNTPLHVAARYGHELLINTLITSG-ADTAKCGIHSM-FPLHLAALNAHSDCCRK 365
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+ G +D + G+T LH AAA G+ +K A+ D RTP+H AA N H
Sbjct: 366 LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCH 425
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIAS 206
IE L A++ E G T +H A+
Sbjct: 426 FHCIETLVTT-GANVNETDDWGRTALHYAA 454
Score = 54.0 bits (124), Expect = 5e-06
Identities = 43/159 (27%), Positives = 62/159 (38%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
GK PL + G + + L+ Q ++ G+T LH+AAR + L+ GA
Sbjct: 281 GKSPLHMTAVHGRFTRSQTLI--QNGGEIDCVDKDGNTPLHVAARYGHELLINTLITSGA 338
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
PLH+AA + D RT +H AA G+ I+L
Sbjct: 339 DTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKL 398
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L A ++ K G T +H A+ N H C L G
Sbjct: 399 LQSS-GADFHKKDKCGRTPLHYAAANCHFHCIETLVTTG 436
Score = 48.4 bits (110), Expect = 3e-04
Identities = 30/96 (31%), Positives = 49/96 (51%), Gaps = 5/96 (5%)
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPMHLAAENGHAAIIE 181
V+ + +TPLH+AA GD +++ G R NA DN TP+H A + ++
Sbjct: 9 VNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNA--KDNMWLTPLHRAVASRSEEAVQ 66
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+L K A + R K+ T +H+A+ N CA ++
Sbjct: 67 VLI-KHSADVNARDKNWQTPLHVAAANKAVKCAEVI 101
Score = 46.0 bits (104), Expect = 0.001
Identities = 26/91 (28%), Positives = 46/91 (50%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
+L E +++ D +T LH+A+ G +++E+L+ GA +NA D TPLH A +
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 1358 HLNVVKLLCESGASPKSETNLNCAPIWFAAS 1388
V++L + A + P+ AA+
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAA 91
Score = 44.0 bits (99), Expect = 0.006
Identities = 47/151 (31%), Positives = 61/151 (40%), Gaps = 8/151 (5%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L A GN ++ LL + A+ K G T LH AA LV GA
Sbjct: 380 GRTCLHAAAAGGNVECIK-LLQSSGADFHKKDK-CGRTPLHYAAANCHFHCIETLVTTGA 437
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+ T+ G+T LH AAA D K G NA E L + + L
Sbjct: 438 NVNETDDWGRTALHYAAA-SDMDRNKTILG---NAHDNSEELERARELKEKEATLCLEFL 493
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADC 213
L + SI R K+G +H A+ GH C
Sbjct: 494 LQNDANPSI--RDKEGYNSIHYAAAYGHRQC 522
Score = 42.3 bits (95), Expect = 0.018
Identities = 25/94 (26%), Positives = 45/94 (47%), Gaps = 2/94 (2%)
Query: 1331 VLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASEN 1390
+L+ + ++N D TPLH AA G +++LL SGA ++ N+ P+ A +
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 1391 HNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKN 1424
+ ++ L+ +H DK + L V + N
Sbjct: 61 SEEAVQVLI--KHSADVNARDKNWQTPLHVAAAN 92
Score = 41.9 bits (94), Expect = 0.024
Identities = 35/120 (29%), Positives = 53/120 (44%), Gaps = 7/120 (5%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA H I TL+ G +V+ T + TALH A S +T+LG D
Sbjct: 413 GRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDR-NKTILGNAHDN 471
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ RE + + C LL++ A P+ ++G +H AA +G+ L L
Sbjct: 472 SEELERARE------LKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLEL 525
>AJ541797-1|CAD62569.2| 765|Homo sapiens ankyrin repeat and kinase
domain containing 1 protein.
Length = 765
Score = 177 bits (431), Expect = 3e-43
Identities = 133/420 (31%), Positives = 198/420 (47%), Gaps = 23/420 (5%)
Query: 994 NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA 1053
N T LH G V+ L+ H +D T TPL +AA Q ++C LLL GA
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLA-HEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 1054 NIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIE 1113
+ + DE G P+H AAQN +L L H V A ++G T H+AA Q + + +
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLD-HGACVDAQEREGWTPLHLAA-QNNFENVA 477
Query: 1114 ELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAA 1173
L+ + ++ TPL +AA GH +V++L GA + R T +HLA
Sbjct: 478 RLLVSRQAD--PNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAV 535
Query: 1174 EHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGV 1233
E G + + + + + + G PLH AA G+ + LL + G
Sbjct: 536 ERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRY-----------GA 584
Query: 1234 SLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS-AGVQADAASNENGYNPLHLACFGGHM 1292
SL L G TPLHLAAY G+ ++ LL S A + A A N + PLHLA G
Sbjct: 585 SLE--LPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVN---WTPLHLAARHGEE 639
Query: 1293 SIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHC 1352
++V LL A+ ++ ++ G T LH+A + V LL A ++A +K GWTP H
Sbjct: 640 AVVSALLQCGADP-NAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHL 698
Query: 1353 AAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDK 1412
AA G+ ++K+L E+GA + ++C P+ A ++ +L KE +L K
Sbjct: 699 AALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATLGGSK 758
Score = 151 bits (365), Expect = 3e-35
Identities = 118/388 (30%), Positives = 183/388 (47%), Gaps = 19/388 (4%)
Query: 853 YACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAH 912
Y KVT + + V+ L+ + DV QT + T A D+ ++AH
Sbjct: 359 YENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGY-TPLLIAAQDQQPDLCALLLAH 417
Query: 913 ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEH 972
+ A NR + GW PL A G LL + A VD + EG + LHLAA++
Sbjct: 418 GADA------NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQN 471
Query: 973 GYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTP 1032
+ V L++ +A N G+T LH+AA G+ LVK L+ A +D +TP
Sbjct: 472 NFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVK-LLTSQGAELDAQQRNLRTP 530
Query: 1033 LHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMAT 1092
LHLA G++ + LL+ GA DA D+ G P+H AA + ++ L+ +L +
Sbjct: 531 LHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLEL-P 589
Query: 1093 TKDGNTCAHIAAIQGSVKVIEELMK-FDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
T G T H+AA +G +++I L + G + A N TPL LAA G VV L
Sbjct: 590 THQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVN----WTPLHLAARHGEEAVVSAL 645
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHG-HTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQ 1210
++ GA ++G T +HLA + +V++++ + + K+G TP H+AA G
Sbjct: 646 LQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVH-ARNKVGWTPAHLAALKGN 704
Query: 1211 AETVRELLSHVPGTVKSEAPTGVSLVPV 1238
++ L V + + GVS P+
Sbjct: 705 TAILKVL---VEAGAQLDVQDGVSCTPL 729
Score = 127 bits (307), Expect = 4e-28
Identities = 108/360 (30%), Positives = 166/360 (46%), Gaps = 28/360 (7%)
Query: 1045 CKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV-----MATTKDGNTC 1099
CKL L ++ +++ Q+ + + + N +QL NLV + ++ T
Sbjct: 310 CKLSLRQPGEVN--EDISQELMDSDSGNYLKRALQL--SDRKNLVPRDEELCIYENKVTP 365
Query: 1100 AHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
H QGSV+ + L+ + V + TPL +AA+ D+ +L+ GA
Sbjct: 366 LHFLVAQGSVEQVRLLLAHE---VDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
+ G +H AA++G ++ + ++ G TPLH+AA E V LL
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQ-NNFENVARLL- 480
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
V +A P L G TPLH+AAY G+ ++V+LL S G + DA N
Sbjct: 481 -----VSRQAD------PNLHEAEGKTPLHVAAYFGHVSLVKLL-TSQGAELDA-QQRNL 527
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
PLHLA G + + LL +S + + D+ G LH A+ G Y + ++LL GA +
Sbjct: 528 RTPLHLAVERGKVRAIQHLL-KSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASL 586
Query: 1340 NATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
GWTPLH AA GHL ++ LL ES A+ + +N P+ AA V+ LL
Sbjct: 587 ELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALL 646
Score = 127 bits (306), Expect = 5e-28
Identities = 117/424 (27%), Positives = 189/424 (44%), Gaps = 40/424 (9%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H G V + LL VD T YT L IA + +P + LL +GAD + R
Sbjct: 366 LHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN-RV 424
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK--FGNLATLVLLL 784
+ PLH AA+ D D A +LL GA + +G TP+H+AA+ F N+A L L+
Sbjct: 425 DEDGWAPLHFAAQNGD-DGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL--LV 481
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD 844
DP +++ G+TPL +A +V+ L A +DA
Sbjct: 482 SRQADPN------LHEA-EGKTPLHVAAYFGHVSLVKLLTS----------QGAELDAQQ 524
Query: 845 EDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNND 904
+ + LH A E K+ + ++ L+++GA + + H A G
Sbjct: 525 RNLRTPLHLAV----ERGKV-----RAIQHLLKSGAVPDALDQSGYGP-LHTAAARGKYL 574
Query: 905 VMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRS 964
+ ++ + +L GWTPL +A ++GH+++++ L +HA + +
Sbjct: 575 ICKMLLRY------GASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWT 628
Query: 965 ALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
LHLAA HG V ALL A N+ ++G T LHLA L + +H+A +
Sbjct: 629 PLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRS-TFLSVINLLEHHANVHA 687
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TP HLAA G + K+L+E GA +D D + P+ A ++ ++ +
Sbjct: 688 RNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGK 747
Query: 1085 HPNL 1088
P++
Sbjct: 748 EPSV 751
Score = 80.6 bits (190), Expect = 6e-14
Identities = 52/159 (32%), Positives = 82/159 (51%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PLL+A + Q + LL A A+ + G LH AA+ D AR+L+D+GA
Sbjct: 395 GYTPLLIAAQ-DQQPDLCALLLAHGADANRVDED-GWAPLHFAAQNGDDGTARLLLDHGA 452
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VDA G TPLH+AA E + + +A+ + + E +TP+H+AA GH ++++L
Sbjct: 453 CVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKL 512
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L + A + + ++ T +H+A G L K G
Sbjct: 513 LTSQ-GAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
Score = 78.2 bits (184), Expect = 3e-13
Identities = 58/159 (36%), Positives = 82/159 (51%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
GK PL +A G+ S+V+ LL++Q AE L A T LHLA R V + L+ GA
Sbjct: 494 GKTPLHVAAYFGHVSLVK-LLTSQGAE-LDAQQRNLRTPLHLAVERGKVRAIQHLLKSGA 551
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V DA + +G PLH AAA G + K A+ + ++ TP+HLAA GH II L
Sbjct: 552 VPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHL 611
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LA+ A++ T +H+A+ +G L + G
Sbjct: 612 LAES-HANMGALGAVNWTPLHLAARHGEEAVVSALLQCG 649
Score = 77.8 bits (183), Expect = 4e-13
Identities = 61/200 (30%), Positives = 95/200 (47%), Gaps = 6/200 (3%)
Query: 27 QQKDLQRLELSFIELNKERAKQKEWKK-LIRDLVFQRGKVPLLLAVEAGNQSMVRELLSA 85
QQ++L+ +E K RA Q K + D + Q G PL A G + + LL
Sbjct: 523 QQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLL-- 580
Query: 86 QTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEP 145
+ L+ T G T LHLAA + +++ +L + A + A TPLH+AA G+E
Sbjct: 581 RYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEA 640
Query: 146 LVKYFYGVRANAAIADNEDRTPMHLAAENG-HAAIIELLADKFKASIFERTKDGSTLMHI 204
+V A+ A+ TP+HLA + ++I LL + A++ R K G T H+
Sbjct: 641 VVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLL--EHHANVHARNKVGWTPAHL 698
Query: 205 ASLNGHADCAMMLFKKGVYL 224
A+L G+ +L + G L
Sbjct: 699 AALKGNTAILKVLVEAGAQL 718
Score = 74.9 bits (176), Expect = 3e-12
Identities = 50/195 (25%), Positives = 90/195 (46%), Gaps = 8/195 (4%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
+++ PL V G+ VR LL+ + + T +G T L +AA+ + D+ +L+
Sbjct: 358 IYENKVTPLHFLVAQGSVEQVRLLLAHEV--DVDCQTASGYTPLLIAAQDQQPDLCALLL 415
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
+GA + + G PLH AA GD+ + A + E TP+HLAA+N
Sbjct: 416 AHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFEN 475
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDE 238
+ LL + +A +G T +H+A+ GH +L +G L +++
Sbjct: 476 VARLLVSR-QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDA-----QQRNLRT 529
Query: 239 VLFVKIENGLIKGLK 253
L + +E G ++ ++
Sbjct: 530 PLHLAVERGKVRAIQ 544
Score = 67.3 bits (157), Expect = 6e-10
Identities = 45/124 (36%), Positives = 62/124 (50%), Gaps = 2/124 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G +H AA +GHV ++ L +G +D + T LH+AVE K ++ LL GA
Sbjct: 493 EGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGA- 551
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V + PLH AA C MLL+ GA T G TP+H+AA G+L +
Sbjct: 552 VPDALDQSGYGPLHTAAARGKYLICK-MLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
Query: 782 LLLE 785
LL E
Sbjct: 611 LLAE 614
Score = 66.1 bits (154), Expect = 1e-09
Identities = 54/161 (33%), Positives = 80/161 (49%), Gaps = 9/161 (5%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA GH+ II+ L + ++ N+T LH+A + AVV LL GAD
Sbjct: 593 GWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADP 652
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + TPLH+A + + LL+ A + + G TP H+AA GN A L +
Sbjct: 653 N-AAEQSGWTPLHLAVQ-RSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKV 710
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHL 823
L+E G ++ + D V+ TPLQ+A RS I+ L
Sbjct: 711 LVEAG------AQLDVQDGVSC-TPLQLALRSRKQGIMSFL 744
Score = 63.3 bits (147), Expect = 9e-09
Identities = 77/309 (24%), Positives = 129/309 (41%), Gaps = 37/309 (11%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G +H AA+ + L+ + ++ + T LH+A ++V+ L GA+
Sbjct: 460 EGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAE 519
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALM-LLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
+ + R TPLH+A + G A+ LLKSGA P+ + G P+H AA G
Sbjct: 520 LDAQQRNLR-TPLHLA--VERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLIC 576
Query: 781 VLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFI 840
+LL G T G TPL +A +I+ L E S A +
Sbjct: 577 KMLLRYGASLELPTH-------QGWTPLHLAAYKGHLEIIHLLAE----------SHANM 619
Query: 841 DAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIA 900
A+ + LH A + +E VV L++ GAD + + T H
Sbjct: 620 GALGAVNWTPLHLAARHGEE---------AVVSALLQCGADPN-AAEQSGWTPLHLAVQR 669
Query: 901 GNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDV 960
+ ++ H + ++ +N +GWTP +A +G+ ++ L+ A++DV D
Sbjct: 670 STFLSVINLLEHHAN------VHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDG 723
Query: 961 EGRSALHLA 969
+ L LA
Sbjct: 724 VSCTPLQLA 732
Score = 58.0 bits (134), Expect = 3e-07
Identities = 39/121 (32%), Positives = 56/121 (46%), Gaps = 2/121 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G +++V LL Q A +G T LHLA +R L+++ A V
Sbjct: 629 PLHLAARHGEEAVVSALL--QCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVH 686
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
A N G TP H+AA +G+ ++K A + D TP+ LA + I+ L
Sbjct: 687 ARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEG 746
Query: 186 K 186
K
Sbjct: 747 K 747
Score = 44.4 bits (100), Expect = 0.004
Identities = 29/98 (29%), Positives = 45/98 (45%), Gaps = 2/98 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
Q G PL LAV+ V LL + A G T HLAA + + + ++LV+
Sbjct: 657 QSGWTPLHLAVQRSTFLSVINLLEHHA--NVHARNKVGWTPAHLAALKGNTAILKVLVEA 714
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAA 158
GA +D +G TPL +A + ++ + G + A
Sbjct: 715 GAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVA 752
Score = 35.1 bits (77), Expect = 2.7
Identities = 20/69 (28%), Positives = 32/69 (46%)
Query: 668 HTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGG 727
H AA G+ I+ L++ G +DV + T L +A+ S K ++ L G V GG
Sbjct: 697 HLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATLGG 756
Query: 728 KQRETPLHI 736
+ + I
Sbjct: 757 SKPGAEMEI 765
>AF525298-1|AAM91924.1| 765|Homo sapiens X-kinase protein.
Length = 765
Score = 177 bits (431), Expect = 3e-43
Identities = 133/420 (31%), Positives = 198/420 (47%), Gaps = 23/420 (5%)
Query: 994 NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA 1053
N T LH G V+ L+ H +D T TPL +AA Q ++C LLL GA
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLA-HEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 1054 NIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIE 1113
+ + DE G P+H AAQN +L L H V A ++G T H+AA Q + + +
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLD-HGACVDAQEREGWTPLHLAA-QNNFENVA 477
Query: 1114 ELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAA 1173
L+ + ++ TPL +AA GH +V++L GA + R T +HLA
Sbjct: 478 RLLVSRQAD--PNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAV 535
Query: 1174 EHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGV 1233
E G + + + + + + G PLH AA G+ + LL + G
Sbjct: 536 ERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRY-----------GA 584
Query: 1234 SLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS-AGVQADAASNENGYNPLHLACFGGHM 1292
SL L G TPLHLAAY G+ ++ LL S A + A A N + PLHLA G
Sbjct: 585 SLE--LPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVN---WTPLHLAARHGEE 639
Query: 1293 SIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHC 1352
++V LL A+ ++ ++ G T LH+A + V LL A ++A +K GWTP H
Sbjct: 640 AVVSALLQCGADP-NAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHL 698
Query: 1353 AAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDK 1412
AA G+ ++K+L E+GA + ++C P+ A ++ +L KE +L K
Sbjct: 699 AALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATLGGSK 758
Score = 151 bits (365), Expect = 3e-35
Identities = 118/388 (30%), Positives = 183/388 (47%), Gaps = 19/388 (4%)
Query: 853 YACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAH 912
Y KVT + + V+ L+ + DV QT + T A D+ ++AH
Sbjct: 359 YENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGY-TPLLIAAQDQQPDLCALLLAH 417
Query: 913 ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEH 972
+ A NR + GW PL A G LL + A VD + EG + LHLAA++
Sbjct: 418 GADA------NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQN 471
Query: 973 GYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTP 1032
+ V L++ +A N G+T LH+AA G+ LVK L+ A +D +TP
Sbjct: 472 NFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVK-LLTSQGAELDAQQRNLRTP 530
Query: 1033 LHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMAT 1092
LHLA G++ + LL+ GA DA D+ G P+H AA + ++ L+ +L +
Sbjct: 531 LHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLEL-P 589
Query: 1093 TKDGNTCAHIAAIQGSVKVIEELMK-FDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
T G T H+AA +G +++I L + G + A N TPL LAA G VV L
Sbjct: 590 THQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVN----WTPLHLAARHGEEAVVSAL 645
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHG-HTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQ 1210
++ GA ++G T +HLA + +V++++ + + K+G TP H+AA G
Sbjct: 646 LQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVH-ARNKVGWTPAHLAALKGN 704
Query: 1211 AETVRELLSHVPGTVKSEAPTGVSLVPV 1238
++ L V + + GVS P+
Sbjct: 705 TAILKVL---VEAGAQLDVQDGVSCTPL 729
Score = 127 bits (307), Expect = 4e-28
Identities = 108/360 (30%), Positives = 166/360 (46%), Gaps = 28/360 (7%)
Query: 1045 CKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV-----MATTKDGNTC 1099
CKL L ++ +++ Q+ + + + N +QL NLV + ++ T
Sbjct: 310 CKLSLRQPGEVN--EDISQELMDSDSGNYLKRALQL--SDRKNLVPRDEELCIYENKVTP 365
Query: 1100 AHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
H QGSV+ + L+ + V + TPL +AA+ D+ +L+ GA
Sbjct: 366 LHFLVAQGSVEQVRLLLAHE---VDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
+ G +H AA++G ++ + ++ G TPLH+AA E V LL
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQ-NNFENVARLL- 480
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
V +A P L G TPLH+AAY G+ ++V+LL S G + DA N
Sbjct: 481 -----VSRQAD------PNLHEAEGKTPLHVAAYFGHVSLVKLL-TSQGAELDA-QQRNL 527
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
PLHLA G + + LL +S + + D+ G LH A+ G Y + ++LL GA +
Sbjct: 528 RTPLHLAVERGKVRAIQHLL-KSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASL 586
Query: 1340 NATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
GWTPLH AA GHL ++ LL ES A+ + +N P+ AA V+ LL
Sbjct: 587 ELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALL 646
Score = 127 bits (306), Expect = 5e-28
Identities = 117/424 (27%), Positives = 189/424 (44%), Gaps = 40/424 (9%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H G V + LL VD T YT L IA + +P + LL +GAD + R
Sbjct: 366 LHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN-RV 424
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK--FGNLATLVLLL 784
+ PLH AA+ D D A +LL GA + +G TP+H+AA+ F N+A L L+
Sbjct: 425 DEDGWAPLHFAAQNGD-DGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL--LV 481
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD 844
DP +++ G+TPL +A +V+ L A +DA
Sbjct: 482 SRQADPN------LHEA-EGKTPLHVAAYFGHVSLVKLLTS----------QGAELDAQQ 524
Query: 845 EDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNND 904
+ + LH A E K+ + ++ L+++GA + + H A G
Sbjct: 525 RNLRTPLHLAV----ERGKV-----RAIQHLLKSGAVPDALDQSGYGP-LHTAAARGKYL 574
Query: 905 VMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRS 964
+ ++ + +L GWTPL +A ++GH+++++ L +HA + +
Sbjct: 575 ICKMLLRY------GASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWT 628
Query: 965 ALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
LHLAA HG V ALL A N+ ++G T LHLA L + +H+A +
Sbjct: 629 PLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRS-TFLSVINLLEHHANVHA 687
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TP HLAA G + K+L+E GA +D D + P+ A ++ ++ +
Sbjct: 688 RNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGK 747
Query: 1085 HPNL 1088
P++
Sbjct: 748 EPSV 751
Score = 80.6 bits (190), Expect = 6e-14
Identities = 52/159 (32%), Positives = 82/159 (51%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PLL+A + Q + LL A A+ + G LH AA+ D AR+L+D+GA
Sbjct: 395 GYTPLLIAAQ-DQQPDLCALLLAHGADANRVDED-GWAPLHFAAQNGDDGTARLLLDHGA 452
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VDA G TPLH+AA E + + +A+ + + E +TP+H+AA GH ++++L
Sbjct: 453 CVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKL 512
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L + A + + ++ T +H+A G L K G
Sbjct: 513 LTSQ-GAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
Score = 78.2 bits (184), Expect = 3e-13
Identities = 58/159 (36%), Positives = 82/159 (51%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
GK PL +A G+ S+V+ LL++Q AE L A T LHLA R V + L+ GA
Sbjct: 494 GKTPLHVAAYFGHVSLVK-LLTSQGAE-LDAQQRNLRTPLHLAVERGKVRAIQHLLKSGA 551
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V DA + +G PLH AAA G + K A+ + ++ TP+HLAA GH II L
Sbjct: 552 VPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHL 611
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LA+ A++ T +H+A+ +G L + G
Sbjct: 612 LAES-HANMGALGAVNWTPLHLAARHGEEAVVSALLQCG 649
Score = 77.8 bits (183), Expect = 4e-13
Identities = 61/200 (30%), Positives = 95/200 (47%), Gaps = 6/200 (3%)
Query: 27 QQKDLQRLELSFIELNKERAKQKEWKK-LIRDLVFQRGKVPLLLAVEAGNQSMVRELLSA 85
QQ++L+ +E K RA Q K + D + Q G PL A G + + LL
Sbjct: 523 QQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLL-- 580
Query: 86 QTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEP 145
+ L+ T G T LHLAA + +++ +L + A + A TPLH+AA G+E
Sbjct: 581 RYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEA 640
Query: 146 LVKYFYGVRANAAIADNEDRTPMHLAAENG-HAAIIELLADKFKASIFERTKDGSTLMHI 204
+V A+ A+ TP+HLA + ++I LL + A++ R K G T H+
Sbjct: 641 VVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLL--EHHANVHARNKVGWTPAHL 698
Query: 205 ASLNGHADCAMMLFKKGVYL 224
A+L G+ +L + G L
Sbjct: 699 AALKGNTAILKVLVEAGAQL 718
Score = 74.9 bits (176), Expect = 3e-12
Identities = 50/195 (25%), Positives = 90/195 (46%), Gaps = 8/195 (4%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
+++ PL V G+ VR LL+ + + T +G T L +AA+ + D+ +L+
Sbjct: 358 IYENKVTPLHFLVAQGSVEQVRLLLAHEV--DVDCQTASGYTPLLIAAQDQQPDLCALLL 415
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
+GA + + G PLH AA GD+ + A + E TP+HLAA+N
Sbjct: 416 AHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFEN 475
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDE 238
+ LL + +A +G T +H+A+ GH +L +G L +++
Sbjct: 476 VARLLVSR-QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDA-----QQRNLRT 529
Query: 239 VLFVKIENGLIKGLK 253
L + +E G ++ ++
Sbjct: 530 PLHLAVERGKVRAIQ 544
Score = 67.3 bits (157), Expect = 6e-10
Identities = 45/124 (36%), Positives = 62/124 (50%), Gaps = 2/124 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G +H AA +GHV ++ L +G +D + T LH+AVE K ++ LL GA
Sbjct: 493 EGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGA- 551
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V + PLH AA C MLL+ GA T G TP+H+AA G+L +
Sbjct: 552 VPDALDQSGYGPLHTAAARGKYLICK-MLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
Query: 782 LLLE 785
LL E
Sbjct: 611 LLAE 614
Score = 66.1 bits (154), Expect = 1e-09
Identities = 54/161 (33%), Positives = 80/161 (49%), Gaps = 9/161 (5%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA GH+ II+ L + ++ N+T LH+A + AVV LL GAD
Sbjct: 593 GWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADP 652
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + TPLH+A + + LL+ A + + G TP H+AA GN A L +
Sbjct: 653 N-AAEQSGWTPLHLAVQ-RSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKV 710
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHL 823
L+E G ++ + D V+ TPLQ+A RS I+ L
Sbjct: 711 LVEAG------AQLDVQDGVSC-TPLQLALRSRKQGIMSFL 744
Score = 63.3 bits (147), Expect = 9e-09
Identities = 77/309 (24%), Positives = 129/309 (41%), Gaps = 37/309 (11%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G +H AA+ + L+ + ++ + T LH+A ++V+ L GA+
Sbjct: 460 EGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAE 519
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALM-LLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
+ + R TPLH+A + G A+ LLKSGA P+ + G P+H AA G
Sbjct: 520 LDAQQRNLR-TPLHLA--VERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLIC 576
Query: 781 VLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFI 840
+LL G T G TPL +A +I+ L E S A +
Sbjct: 577 KMLLRYGASLELPTH-------QGWTPLHLAAYKGHLEIIHLLAE----------SHANM 619
Query: 841 DAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIA 900
A+ + LH A + +E VV L++ GAD + + T H
Sbjct: 620 GALGAVNWTPLHLAARHGEE---------AVVSALLQCGADPN-AAEQSGWTPLHLAVQR 669
Query: 901 GNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDV 960
+ ++ H + ++ +N +GWTP +A +G+ ++ L+ A++DV D
Sbjct: 670 STFLSVINLLEHHAN------VHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDG 723
Query: 961 EGRSALHLA 969
+ L LA
Sbjct: 724 VSCTPLQLA 732
Score = 58.0 bits (134), Expect = 3e-07
Identities = 39/121 (32%), Positives = 56/121 (46%), Gaps = 2/121 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G +++V LL Q A +G T LHLA +R L+++ A V
Sbjct: 629 PLHLAARHGEEAVVSALL--QCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVH 686
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
A N G TP H+AA +G+ ++K A + D TP+ LA + I+ L
Sbjct: 687 ARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEG 746
Query: 186 K 186
K
Sbjct: 747 K 747
Score = 44.4 bits (100), Expect = 0.004
Identities = 29/98 (29%), Positives = 45/98 (45%), Gaps = 2/98 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
Q G PL LAV+ V LL + A G T HLAA + + + ++LV+
Sbjct: 657 QSGWTPLHLAVQRSTFLSVINLLEHHA--NVHARNKVGWTPAHLAALKGNTAILKVLVEA 714
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAA 158
GA +D +G TPL +A + ++ + G + A
Sbjct: 715 GAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVA 752
Score = 35.1 bits (77), Expect = 2.7
Identities = 20/69 (28%), Positives = 32/69 (46%)
Query: 668 HTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGG 727
H AA G+ I+ L++ G +DV + T L +A+ S K ++ L G V GG
Sbjct: 697 HLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATLGG 756
Query: 728 KQRETPLHI 736
+ + I
Sbjct: 757 SKPGAEMEI 765
>AF487542-1|AAQ09005.1| 765|Homo sapiens protein kinase PKK2 protein.
Length = 765
Score = 177 bits (431), Expect = 3e-43
Identities = 133/420 (31%), Positives = 198/420 (47%), Gaps = 23/420 (5%)
Query: 994 NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA 1053
N T LH G V+ L+ H +D T TPL +AA Q ++C LLL GA
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLA-HEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 1054 NIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIE 1113
+ + DE G P+H AAQN +L L H V A ++G T H+AA Q + + +
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLD-HGACVDAQEREGWTPLHLAA-QNNFENVA 477
Query: 1114 ELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAA 1173
L+ + ++ TPL +AA GH +V++L GA + R T +HLA
Sbjct: 478 RLLVSRQAD--PNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAV 535
Query: 1174 EHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGV 1233
E G + + + + + + G PLH AA G+ + LL + G
Sbjct: 536 ERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRY-----------GA 584
Query: 1234 SLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS-AGVQADAASNENGYNPLHLACFGGHM 1292
SL L G TPLHLAAY G+ ++ LL S A + A A N + PLHLA G
Sbjct: 585 SLE--LPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVN---WTPLHLAARHGEE 639
Query: 1293 SIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHC 1352
++V LL A+ ++ ++ G T LH+A + V LL A ++A +K GWTP H
Sbjct: 640 AVVSALLQCGADP-NAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHL 698
Query: 1353 AAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDK 1412
AA G+ ++K+L E+GA + ++C P+ A ++ +L KE +L K
Sbjct: 699 AALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATLGGSK 758
Score = 151 bits (365), Expect = 3e-35
Identities = 118/388 (30%), Positives = 183/388 (47%), Gaps = 19/388 (4%)
Query: 853 YACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAH 912
Y KVT + + V+ L+ + DV QT + T A D+ ++AH
Sbjct: 359 YENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGY-TPLLIAAQDQQPDLCALLLAH 417
Query: 913 ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEH 972
+ A NR + GW PL A G LL + A VD + EG + LHLAA++
Sbjct: 418 GADA------NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQN 471
Query: 973 GYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTP 1032
+ V L++ +A N G+T LH+AA G+ LVK L+ A +D +TP
Sbjct: 472 NFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVK-LLTSQGAELDAQQRNLRTP 530
Query: 1033 LHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMAT 1092
LHLA G++ + LL+ GA DA D+ G P+H AA + ++ L+ +L +
Sbjct: 531 LHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLEL-P 589
Query: 1093 TKDGNTCAHIAAIQGSVKVIEELMK-FDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
T G T H+AA +G +++I L + G + A N TPL LAA G VV L
Sbjct: 590 THQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVN----WTPLHLAARHGEEAVVSAL 645
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHG-HTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQ 1210
++ GA ++G T +HLA + +V++++ + + K+G TP H+AA G
Sbjct: 646 LQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVH-ARNKVGWTPAHLAALKGN 704
Query: 1211 AETVRELLSHVPGTVKSEAPTGVSLVPV 1238
++ L V + + GVS P+
Sbjct: 705 TAILKVL---VEAGAQLDVQDGVSCTPL 729
Score = 127 bits (307), Expect = 4e-28
Identities = 108/360 (30%), Positives = 166/360 (46%), Gaps = 28/360 (7%)
Query: 1045 CKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV-----MATTKDGNTC 1099
CKL L ++ +++ Q+ + + + N +QL NLV + ++ T
Sbjct: 310 CKLSLRQPGEVN--EDISQELMDSDSGNYLKRALQL--SDRKNLVPRDEELCIYENKVTP 365
Query: 1100 AHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
H QGSV+ + L+ + V + TPL +AA+ D+ +L+ GA
Sbjct: 366 LHFLVAQGSVEQVRLLLAHE---VDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
+ G +H AA++G ++ + ++ G TPLH+AA E V LL
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQ-NNFENVARLL- 480
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
V +A P L G TPLH+AAY G+ ++V+LL S G + DA N
Sbjct: 481 -----VSRQAD------PNLHEAEGKTPLHVAAYFGHVSLVKLL-TSQGAELDA-QQRNL 527
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
PLHLA G + + LL +S + + D+ G LH A+ G Y + ++LL GA +
Sbjct: 528 RTPLHLAVERGKVRAIQHLL-KSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASL 586
Query: 1340 NATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
GWTPLH AA GHL ++ LL ES A+ + +N P+ AA V+ LL
Sbjct: 587 ELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALL 646
Score = 127 bits (306), Expect = 5e-28
Identities = 117/424 (27%), Positives = 189/424 (44%), Gaps = 40/424 (9%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H G V + LL VD T YT L IA + +P + LL +GAD + R
Sbjct: 366 LHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN-RV 424
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK--FGNLATLVLLL 784
+ PLH AA+ D D A +LL GA + +G TP+H+AA+ F N+A L L+
Sbjct: 425 DEDGWAPLHFAAQNGD-DGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL--LV 481
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD 844
DP +++ G+TPL +A +V+ L A +DA
Sbjct: 482 SRQADPN------LHEA-EGKTPLHVAAYFGHVSLVKLLTS----------QGAELDAQQ 524
Query: 845 EDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNND 904
+ + LH A E K+ + ++ L+++GA + + H A G
Sbjct: 525 RNLRTPLHLAV----ERGKV-----RAIQHLLKSGAVPDALDQSGYGP-LHTAAARGKYL 574
Query: 905 VMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRS 964
+ ++ + +L GWTPL +A ++GH+++++ L +HA + +
Sbjct: 575 ICKMLLRY------GASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWT 628
Query: 965 ALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
LHLAA HG V ALL A N+ ++G T LHLA L + +H+A +
Sbjct: 629 PLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRS-TFLSVINLLEHHANVHA 687
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TP HLAA G + K+L+E GA +D D + P+ A ++ ++ +
Sbjct: 688 RNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGK 747
Query: 1085 HPNL 1088
P++
Sbjct: 748 EPSV 751
Score = 80.6 bits (190), Expect = 6e-14
Identities = 52/159 (32%), Positives = 82/159 (51%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PLL+A + Q + LL A A+ + G LH AA+ D AR+L+D+GA
Sbjct: 395 GYTPLLIAAQ-DQQPDLCALLLAHGADANRVDED-GWAPLHFAAQNGDDGTARLLLDHGA 452
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VDA G TPLH+AA E + + +A+ + + E +TP+H+AA GH ++++L
Sbjct: 453 CVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKL 512
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L + A + + ++ T +H+A G L K G
Sbjct: 513 LTSQ-GAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
Score = 78.2 bits (184), Expect = 3e-13
Identities = 58/159 (36%), Positives = 82/159 (51%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
GK PL +A G+ S+V+ LL++Q AE L A T LHLA R V + L+ GA
Sbjct: 494 GKTPLHVAAYFGHVSLVK-LLTSQGAE-LDAQQRNLRTPLHLAVERGKVRAIQHLLKSGA 551
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V DA + +G PLH AAA G + K A+ + ++ TP+HLAA GH II L
Sbjct: 552 VPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHL 611
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LA+ A++ T +H+A+ +G L + G
Sbjct: 612 LAES-HANMGALGAVNWTPLHLAARHGEEAVVSALLQCG 649
Score = 77.8 bits (183), Expect = 4e-13
Identities = 61/200 (30%), Positives = 95/200 (47%), Gaps = 6/200 (3%)
Query: 27 QQKDLQRLELSFIELNKERAKQKEWKK-LIRDLVFQRGKVPLLLAVEAGNQSMVRELLSA 85
QQ++L+ +E K RA Q K + D + Q G PL A G + + LL
Sbjct: 523 QQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLL-- 580
Query: 86 QTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEP 145
+ L+ T G T LHLAA + +++ +L + A + A TPLH+AA G+E
Sbjct: 581 RYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEA 640
Query: 146 LVKYFYGVRANAAIADNEDRTPMHLAAENG-HAAIIELLADKFKASIFERTKDGSTLMHI 204
+V A+ A+ TP+HLA + ++I LL + A++ R K G T H+
Sbjct: 641 VVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLL--EHHANVHARNKVGWTPAHL 698
Query: 205 ASLNGHADCAMMLFKKGVYL 224
A+L G+ +L + G L
Sbjct: 699 AALKGNTAILKVLVEAGAQL 718
Score = 74.9 bits (176), Expect = 3e-12
Identities = 50/195 (25%), Positives = 90/195 (46%), Gaps = 8/195 (4%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
+++ PL V G+ VR LL+ + + T +G T L +AA+ + D+ +L+
Sbjct: 358 IYENKVTPLHFLVAQGSVEQVRLLLAHEV--DVDCQTASGYTPLLIAAQDQQPDLCALLL 415
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
+GA + + G PLH AA GD+ + A + E TP+HLAA+N
Sbjct: 416 AHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFEN 475
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDE 238
+ LL + +A +G T +H+A+ GH +L +G L +++
Sbjct: 476 VARLLVSR-QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDA-----QQRNLRT 529
Query: 239 VLFVKIENGLIKGLK 253
L + +E G ++ ++
Sbjct: 530 PLHLAVERGKVRAIQ 544
Score = 67.3 bits (157), Expect = 6e-10
Identities = 45/124 (36%), Positives = 62/124 (50%), Gaps = 2/124 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G +H AA +GHV ++ L +G +D + T LH+AVE K ++ LL GA
Sbjct: 493 EGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGA- 551
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V + PLH AA C MLL+ GA T G TP+H+AA G+L +
Sbjct: 552 VPDALDQSGYGPLHTAAARGKYLICK-MLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
Query: 782 LLLE 785
LL E
Sbjct: 611 LLAE 614
Score = 66.1 bits (154), Expect = 1e-09
Identities = 54/161 (33%), Positives = 80/161 (49%), Gaps = 9/161 (5%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA GH+ II+ L + ++ N+T LH+A + AVV LL GAD
Sbjct: 593 GWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADP 652
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + TPLH+A + + LL+ A + + G TP H+AA GN A L +
Sbjct: 653 N-AAEQSGWTPLHLAVQ-RSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKV 710
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHL 823
L+E G ++ + D V+ TPLQ+A RS I+ L
Sbjct: 711 LVEAG------AQLDVQDGVSC-TPLQLALRSRKQGIMSFL 744
Score = 63.3 bits (147), Expect = 9e-09
Identities = 77/309 (24%), Positives = 129/309 (41%), Gaps = 37/309 (11%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G +H AA+ + L+ + ++ + T LH+A ++V+ L GA+
Sbjct: 460 EGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAE 519
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALM-LLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
+ + R TPLH+A + G A+ LLKSGA P+ + G P+H AA G
Sbjct: 520 LDAQQRNLR-TPLHLA--VERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLIC 576
Query: 781 VLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFI 840
+LL G T G TPL +A +I+ L E S A +
Sbjct: 577 KMLLRYGASLELPTH-------QGWTPLHLAAYKGHLEIIHLLAE----------SHANM 619
Query: 841 DAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIA 900
A+ + LH A + +E VV L++ GAD + + T H
Sbjct: 620 GALGAVNWTPLHLAARHGEE---------AVVSALLQCGADPN-AAEQSGWTPLHLAVQR 669
Query: 901 GNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDV 960
+ ++ H + ++ +N +GWTP +A +G+ ++ L+ A++DV D
Sbjct: 670 STFLSVINLLEHHAN------VHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDG 723
Query: 961 EGRSALHLA 969
+ L LA
Sbjct: 724 VSCTPLQLA 732
Score = 58.0 bits (134), Expect = 3e-07
Identities = 39/121 (32%), Positives = 56/121 (46%), Gaps = 2/121 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G +++V LL Q A +G T LHLA +R L+++ A V
Sbjct: 629 PLHLAARHGEEAVVSALL--QCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVH 686
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
A N G TP H+AA +G+ ++K A + D TP+ LA + I+ L
Sbjct: 687 ARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEG 746
Query: 186 K 186
K
Sbjct: 747 K 747
Score = 44.4 bits (100), Expect = 0.004
Identities = 29/98 (29%), Positives = 45/98 (45%), Gaps = 2/98 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
Q G PL LAV+ V LL + A G T HLAA + + + ++LV+
Sbjct: 657 QSGWTPLHLAVQRSTFLSVINLLEHHA--NVHARNKVGWTPAHLAALKGNTAILKVLVEA 714
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAA 158
GA +D +G TPL +A + ++ + G + A
Sbjct: 715 GAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVA 752
Score = 35.1 bits (77), Expect = 2.7
Identities = 20/69 (28%), Positives = 32/69 (46%)
Query: 668 HTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGG 727
H AA G+ I+ L++ G +DV + T L +A+ S K ++ L G V GG
Sbjct: 697 HLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATLGG 756
Query: 728 KQRETPLHI 736
+ + I
Sbjct: 757 SKPGAEMEI 765
>BC024725-1|AAH24725.1| 743|Homo sapiens ANKRD50 protein protein.
Length = 743
Score = 176 bits (429), Expect = 6e-43
Identities = 135/432 (31%), Positives = 217/432 (50%), Gaps = 28/432 (6%)
Query: 973 GYLQVCDALLTNKAFINSKARNGRTALHLAAM-----NGYAHLVKFLIRDHNAMIDVLTL 1027
G+ ++ + LL + A +N + +GRTAL +AA+ G+A +V LI D A +D
Sbjct: 2 GHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLI-DRGAEVDHCDK 60
Query: 1028 KKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPN 1087
TPL +AA G ++V LLLE GA++D TD G+ P+ AAA ++ VV L
Sbjct: 61 DGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGA- 119
Query: 1088 LVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADV 1147
V + +G T IA+ QG+V+V+ L+ DR G+ TPL +AA GH +
Sbjct: 120 AVDSIDSEGRTVLSIASAQGNVEVVRTLL--DR-GLDENHRDDAGWTPLHMAAFEGHRLI 176
Query: 1148 VRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKL-GLTPLHIAA 1206
L+ GA + + G LA++ GH + + ++ N I + G L +AA
Sbjct: 177 CEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLE-NKSNIDQRGYDGRNALRVAA 235
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS 1266
G + V L SH V + G + +L E+ LT +A Y L N
Sbjct: 236 LEGHRDIVELLFSH-GADVNCKDADGRPTLYILALENQLT---MAEY--------FLENG 283
Query: 1267 AGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHY 1326
A V+A S+ G LH++C+ GHM +V +L++ A++ ++ D ++ L A+ GH
Sbjct: 284 ANVEA---SDAEGRTALHVSCWQGHMEMVQVLIAYHADV-NAADNEKRSALQSAAWQGHV 339
Query: 1327 QMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFA 1386
++V++L+ GA ++ T G T L AA+ GH++VV++L E GA P + A
Sbjct: 340 KVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVA 399
Query: 1387 ASENHNDVLEYL 1398
A H+ +++ L
Sbjct: 400 AKNGHSQIIKLL 411
Score = 150 bits (363), Expect = 6e-35
Identities = 124/440 (28%), Positives = 205/440 (46%), Gaps = 43/440 (9%)
Query: 750 LLKSGAGPNKATEDGMTPVHVAA-----KFGNLATLVLLLEDGGDPLRKTKVCIYDVVTG 804
LL GA N DG T + VAA G+ + + LL++ G + C D G
Sbjct: 10 LLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAE----VDHCDKD---G 62
Query: 805 ETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKI 864
TPL +A D+V L+E D +D D +G + L A +
Sbjct: 63 MTPLLVAAYEGHVDVVDLLLEGGAD----------VDHTDNNGRTPLLAAASM------- 105
Query: 865 PTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNR 924
VV L+ GA V T + GN +V+ ++ D N
Sbjct: 106 --GHASVVNTLLFWGAAVD-SIDSEGRTVLSIASAQGNVEVVRTLL------DRGLDENH 156
Query: 925 QNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTN 984
++ GWTPL +A GH + L+ AR + D +GR LA++ G+ LL N
Sbjct: 157 RDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLEN 216
Query: 985 KAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEV 1044
K+ I+ + +GR AL +AA+ G+ +V+ L H A ++ + L++ A Q+ +
Sbjct: 217 KSNIDQRGYDGRNALRVAALEGHRDIVELLF-SHGADVNCKDADGRPTLYILALENQLTM 275
Query: 1045 CKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
+ LE GAN++A+D G+ +H + + E+VQ+ + H + V A + + AA
Sbjct: 276 AEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHAD-VNAADNEKRSALQSAA 334
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
QG VKV++ L++ G + +T L +AA+ GH DVV+VL+ GA ++
Sbjct: 335 WQGHVKVVQLLIEH---GAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQF 391
Query: 1165 GLTAVHLAAEHGHTNVLDVM 1184
G TA+ +AA++GH+ ++ ++
Sbjct: 392 GRTAMRVAAKNGHSQIIKLL 411
Score = 140 bits (340), Expect = 4e-32
Identities = 123/429 (28%), Positives = 198/429 (46%), Gaps = 29/429 (6%)
Query: 1006 GYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAA-----ASGQIEVCKLLLELGANIDATDE 1060
G+ +V+ L+ DH A ++ + +T L +AA + G V LL++ GA +D D+
Sbjct: 2 GHREIVEHLL-DHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDK 60
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDR 1120
G P+ AA + +VV L L+ + V T +G T AA G V+ L+ F
Sbjct: 61 DGMTPLLVAAYEGHVDVVDLLLEGGAD-VDHTDNNGRTPLLAAASMGHASVVNTLL-FWG 118
Query: 1121 TGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNV 1180
V S ++ T L +A+ G+ +VVR L+ G + AG T +H+AA GH +
Sbjct: 119 AAVDSIDSE--GRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLI 176
Query: 1181 LDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLG 1240
+ + G P +A+ G + V+ LL + KS + G
Sbjct: 177 CEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLEN-----KSN-------IDQRG 224
Query: 1241 AESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLS 1300
+ G L +AA G+ ++V LL S G + + +G L++ +++ L
Sbjct: 225 YD-GRNALRVAALEGHRDIVELLF-SHGADVNC-KDADGRPTLYILALENQLTMAEYFLE 281
Query: 1301 RSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
A + ++D G+T LH++ GH +MV+VL+ A++NA D + L AA GH+
Sbjct: 282 NGANV-EASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVK 340
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMV 1420
VV+LL E GA N + AA E H DV++ LL EH D+ + V
Sbjct: 341 VVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLL--EHGADPNHADQFGRTAMRV 398
Query: 1421 CSKN-HNNI 1428
+KN H+ I
Sbjct: 399 AAKNGHSQI 407
Score = 137 bits (332), Expect = 3e-31
Identities = 117/451 (25%), Positives = 212/451 (47%), Gaps = 43/451 (9%)
Query: 711 VVETLLGYGADVHIRGGKQRETPLHIAARIPDGDK----CALMLLKSGAGPNKATEDGMT 766
+VE LL +GA+V+ R T L +AA K +L+ GA + +DGMT
Sbjct: 6 IVEHLLDHGAEVNHEDVDGR-TALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMT 64
Query: 767 PVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
P+ VAA G++ + LLLE G D G TPL A +V L+ +
Sbjct: 65 PLLVAAYEGHVDVVDLLLEGGADVDHTDN-------NGRTPLLAAASMGHASVVNTLLFW 117
Query: 827 VKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQT 886
A +D++D +G + L A + +VV+ L++ G D + +
Sbjct: 118 ----------GAAVDSIDSEGRTVLSIAS---------AQGNVEVVRTLLDRGLDENHRD 158
Query: 887 RHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVN 946
T H A G+ + +I + N ++ G P ++A GH V
Sbjct: 159 DAGW-TPLHMAAFEGHRLICEALI------EQGARTNEIDNDGRIPFILASQEGHYDCVQ 211
Query: 947 TLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNG 1006
LL N + +D +GR+AL +AA G+ + + L ++ A +N K +GR L++ A+
Sbjct: 212 ILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALEN 271
Query: 1007 YAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPI 1066
+ ++ + ++ A ++ + +T LH++ G +E+ ++L+ A+++A D + +
Sbjct: 272 QLTMAEYFL-ENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSAL 330
Query: 1067 HAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISA 1126
+AA + +VVQL + +H +V T G T IAA +G + V++ L++ G
Sbjct: 331 QSAAWQGHVKVVQLLI-EHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEH---GADPN 386
Query: 1127 RNKLNDSTPLQLAAEGGHADVVRVLVRAGAS 1157
T +++AA+ GH+ ++++L + GAS
Sbjct: 387 HADQFGRTAMRVAAKNGHSQIIKLLEKYGAS 417
Score = 135 bits (326), Expect = 2e-30
Identities = 101/363 (27%), Positives = 180/363 (49%), Gaps = 12/363 (3%)
Query: 871 VVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGW 930
VV L+E GADV T +N T A G+ V+ ++ A++ +S G
Sbjct: 77 VVDLLLEGGADVD-HTDNNGRTPLLAAASMGHASVVNTLLFW------GAAVDSIDSEGR 129
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
T L IA +G++++V TLL + D G + LH+AA G+ +C+AL+ A N
Sbjct: 130 TVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNE 189
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
+GR LA+ G+ V+ L+ ++ + ID + L +AA G ++ +LL
Sbjct: 190 IDNDGRIPFILASQEGHYDCVQILL-ENKSNIDQRGYDGRNALRVAALEGHRDIVELLFS 248
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
GA+++ D G+ ++ A N + + FL+ N V A+ +G T H++ QG ++
Sbjct: 249 HGADVNCKDADGRPTLYILALENQLTMAEYFLENGAN-VEASDAEGRTALHVSCWQGHME 307
Query: 1111 VIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVH 1170
+++ L+ + V +A N+ + LQ AA GH VV++L+ GA G TA+
Sbjct: 308 MVQVLIAY-HADVNAADNEKRSA--LQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALC 364
Query: 1171 LAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAP 1230
+AA+ GH +V+ V+ + + G T + +AA G ++ ++ L + ++ +P
Sbjct: 365 IAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSP 424
Query: 1231 TGV 1233
+ V
Sbjct: 425 SPV 427
Score = 132 bits (319), Expect = 1e-29
Identities = 129/462 (27%), Positives = 203/462 (43%), Gaps = 41/462 (8%)
Query: 821 RHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGA 880
R ++E + DH E ++ D DG +AL A V VV LI+ GA
Sbjct: 4 REIVEHLLDHGAE------VNHEDVDGRTALSVAALC----VPASKGHASVVSLLIDRGA 53
Query: 881 DVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRG 940
+V + T A G+ DV+ ++ ADV N G TPLL A G
Sbjct: 54 EVD-HCDKDGMTPLLVAAYEGHVDVVDLLLE--GGADVDHTDNN----GRTPLLAAASMG 106
Query: 941 HMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALH 1000
H +VNTLL A VD D EGR+ L +A+ G ++V LL N + G T LH
Sbjct: 107 HASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLH 166
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDE 1060
+AA G+ + + LI + A + + + P LA+ G + ++LLE +NID
Sbjct: 167 MAAFEGHRLICEALI-EQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGY 225
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDR 1120
G+ + AA + ++V+L L H V DG +I A++ + + E ++
Sbjct: 226 DGRNALRVAALEGHRDIVEL-LFSHGADVNCKDADGRPTLYILALENQLTMAEYFLE--- 281
Query: 1121 TGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNV 1180
G + T L ++ GH ++V+VL+ A + +A+ AA GH V
Sbjct: 282 NGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKV 341
Query: 1181 LDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLG 1240
+ ++ + + G T L IAA G + V+ LL H G + A
Sbjct: 342 VQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEH--GADPNHAD---------- 389
Query: 1241 AESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNP 1282
+ G T + +AA NG+ +++LL + AS+ NG +P
Sbjct: 390 -QFGRTAMRVAAKNGHSQIIKLL------EKYGASSLNGCSP 424
Score = 126 bits (303), Expect = 1e-27
Identities = 121/410 (29%), Positives = 187/410 (45%), Gaps = 38/410 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DG + AA GHV +++ LL+ G VD T N+ T L A +VV TLL +GA
Sbjct: 61 DGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAA 120
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V + R T L IA+ + LL G N + G TP+H+AA G+
Sbjct: 121 VDSIDSEGR-TVLSIAS-AQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICE 178
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
L+E G +T D G P +A + D V+ L+E + + ID
Sbjct: 179 ALIEQGA----RTNEIDND---GRIPFILASQEGHYDCVQILLE----------NKSNID 221
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
DG +AL A R +V+ L +GADV+ + T Y
Sbjct: 222 QRGYDGRNALRVAAL---------EGHRDIVELLFSHGADVNCKDADGRPTL--YILALE 270
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
N M E + A+V + ++ G T L ++C +GHM++V L+ HA V+ D E
Sbjct: 271 NQLTMAEYFLE-NGANVEAS----DAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNE 325
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM 1021
RSAL AA G+++V L+ + A ++ G TAL +AA G+ +V+ L+ +H A
Sbjct: 326 KRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLL-EHGAD 384
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQ 1071
+ +T + +AA +G ++ KLL + GA+ + + P+H Q
Sbjct: 385 PNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS--SLNGCSPSPVHTMEQ 432
Score = 125 bits (301), Expect = 2e-27
Identities = 125/427 (29%), Positives = 204/427 (47%), Gaps = 38/427 (8%)
Query: 674 GHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPA------VVETLLGYGADVHIRGG 727
GH I+ LL G V+ D TAL +A C PA VV L+ GA+V
Sbjct: 2 GHREIVEHLLDHGAEVNHEDVDGRTALSVAA-LCVPASKGHASVVSLLIDRGAEVD-HCD 59
Query: 728 KQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
K TPL +AA D L LL+ GA + +G TP+ AA G+ + + LL G
Sbjct: 60 KDGMTPLLVAAYEGHVDVVDL-LLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWG 118
Query: 788 GDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIE--FVKDHKGESVSTAFIDAVDE 845
V D G T L +A ++VR L++ ++H+ ++ T A E
Sbjct: 119 ------AAVDSID-SEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFE 171
Query: 846 DG---ASALHYACKVTKE---EVKIP--TADRQ----VVKCLIENGADVSLQTRHNHETA 893
AL T E + +IP A ++ V+ L+EN +++ Q ++ A
Sbjct: 172 GHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNID-QRGYDGRNA 230
Query: 894 FHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHA 953
A+ G+ D++ + +H ADV N +++ G L I + + L N A
Sbjct: 231 LRVAALEGHRDIVELLFSH--GADV----NCKDADGRPTLYILALENQLTMAEYFLENGA 284
Query: 954 RVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKF 1013
V+ D EGR+ALH++ G++++ L+ A +N+ R+AL AA G+ +V+
Sbjct: 285 NVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQL 344
Query: 1014 LIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNN 1073
LI +H A++D + T L +AA G I+V ++LLE GA+ + D+ G+ + AA+N
Sbjct: 345 LI-EHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNG 403
Query: 1074 YSEVVQL 1080
+S++++L
Sbjct: 404 HSQIIKL 410
Score = 89.0 bits (211), Expect = 2e-16
Identities = 53/159 (33%), Positives = 84/159 (52%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ PLL A G+ S+V LL A + + G T L +A+ + +V++ R L+D G
Sbjct: 95 GRTPLLAAASMGHASVVNTLLFWGAA--VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGL 152
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ + AG TPLH+AA EG + + A DN+ R P LA++ GH +++
Sbjct: 153 DENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQI 212
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L + K++I +R DG + +A+L GH D +LF G
Sbjct: 213 LLEN-KSNIDQRGYDGRNALRVAALEGHRDIVELLFSHG 250
Score = 74.5 bits (175), Expect = 4e-12
Identities = 46/159 (28%), Positives = 81/159 (50%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L +A G++ +V ELL + A+ + G L++ A + MA ++ GA
Sbjct: 227 GRNALRVAALEGHRDIV-ELLFSHGAD-VNCKDADGRPTLYILALENQLTMAEYFLENGA 284
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+A++ G+T LH++ +G +V+ A+ ADNE R+ + AA GH +++L
Sbjct: 285 NVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQL 344
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L + A + G+T + IA+ GH D +L + G
Sbjct: 345 LIE-HGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHG 382
Score = 66.9 bits (156), Expect = 7e-10
Identities = 45/152 (29%), Positives = 73/152 (48%), Gaps = 4/152 (2%)
Query: 74 GNQSMVRELL---SAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGA 130
G++ +V LL + E + T AL + A + + +L+D GA VD +
Sbjct: 2 GHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKD 61
Query: 131 GQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKAS 190
G TPL +AA EG +V A+ DN RTP+ AA GHA+++ L + A+
Sbjct: 62 GMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLL-FWGAA 120
Query: 191 IFERTKDGSTLMHIASLNGHADCAMMLFKKGV 222
+ +G T++ IAS G+ + L +G+
Sbjct: 121 VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGL 152
Score = 66.5 bits (155), Expect = 1e-09
Identities = 46/128 (35%), Positives = 71/128 (55%), Gaps = 3/128 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L ++ G+ MV+ L++ + A +AL AA + V + ++L+++GA
Sbjct: 293 GRTALHVSCWQGHMEMVQVLIAYHA--DVNAADNEKRSALQSAAWQGHVKVVQLLIEHGA 350
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VVD T G T L IAA EG +V+ A+ AD RT M +AA+NGH+ II+L
Sbjct: 351 VVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKL 410
Query: 183 LADKFKAS 190
L +K+ AS
Sbjct: 411 L-EKYGAS 417
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/132 (27%), Positives = 66/132 (50%), Gaps = 2/132 (1%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K DG +++ A + + L+ G +V+ + + TALH++ +V+ L+ Y
Sbjct: 256 KDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAY 315
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
ADV+ ++R + L AA K +L++ GA + G T + +AA+ G++
Sbjct: 316 HADVNAADNEKR-SALQSAA-WQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHID 373
Query: 779 TLVLLLEDGGDP 790
+ +LLE G DP
Sbjct: 374 VVQVLLEHGADP 385
Score = 53.6 bits (123), Expect = 7e-06
Identities = 79/293 (26%), Positives = 120/293 (40%), Gaps = 35/293 (11%)
Query: 656 EKYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETL 715
E ++ G +H AA GH I L+++G + ND +A + V+ L
Sbjct: 154 ENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQIL 213
Query: 716 LGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
L +++ RG R L +AA D L L GA N DG +++ A
Sbjct: 214 LENKSNIDQRGYDGRNA-LRVAALEGHRDIVEL-LFSHGADVNCKDADGRPTLYILALEN 271
Query: 776 NLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESV 835
L LE+G + V D G T L ++C ++V+ LI + D
Sbjct: 272 QLTMAEYFLENGAN------VEASD-AEGRTALHVSCWQGHMEMVQVLIAYHAD------ 318
Query: 836 STAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFH 895
++A D + SAL A + VK VV+ LIE+GA V T + TA
Sbjct: 319 ----VNAADNEKRSALQSA--AWQGHVK-------VVQLLIEHGAVVD-HTCNQGATALC 364
Query: 896 YCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTL 948
A G+ DV+ ++ H AD N + G T + +A GH Q++ L
Sbjct: 365 IAAQEGHIDVVQVLLEH--GADP----NHADQFGRTAMRVAAKNGHSQIIKLL 411
>AY367056-1|AAQ72374.1| 520|Homo sapiens KIAA0379-like protein
protein.
Length = 520
Score = 175 bits (426), Expect = 1e-42
Identities = 142/481 (29%), Positives = 227/481 (47%), Gaps = 30/481 (6%)
Query: 913 ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEH 972
+ T+ + N +PL +A + GH Q + L+ + +DV + GR+ L LAA
Sbjct: 1 METSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFK 60
Query: 973 GYLQVCDALLTNKAFINSKARN-GRTALHLAAMNGYAHLVKFLIRDHNAM--IDVLTLKK 1029
G+++ D L+ A I K RT +H AA NG++ ++ LI + +D+
Sbjct: 61 GHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNG 120
Query: 1030 QTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
QTPL L+ +G + LL GAN+DA D+ G+ +H A + E V LQ +
Sbjct: 121 QTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCL 180
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDS-TPLQLAAEGGHADVV 1148
+ ++ G T H++A G + V+ L++ + + N T L A GH V
Sbjct: 181 LRDSR-GRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCV 239
Query: 1149 RVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI--SSKKLGLTPLHIAA 1206
+L+ E A + +H A + + +++ T I ++ G TPLH AA
Sbjct: 240 ELLLEQEVFQKTEGNA-FSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAA 298
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS 1266
+ E ++ LLSH V S TG TPL +AA NG N V +L++S
Sbjct: 299 FTDHVECLQLLLSH-NAQVNSVDSTGK------------TPLMMAAENGQTNTVEMLVSS 345
Query: 1267 AGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAE--LLHSTDRHGKTGLHIASTHG 1324
A + N LHLAC GH + L+L + + L+++T+ +T LH+A+ +G
Sbjct: 346 ASAELTLQDNSKN-TALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNG 404
Query: 1325 HYQMVEVLLGQGAEINATDKNGWTP-LHCA-----AKAGHLNVVKLLCESGASPKSETNL 1378
+V+ LLG+GA + A D+NG+TP L CA A L + ++ S +SP S
Sbjct: 405 LTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPVSSSSPLSSLTF 464
Query: 1379 N 1379
N
Sbjct: 465 N 465
Score = 165 bits (400), Expect = 2e-39
Identities = 139/476 (29%), Positives = 217/476 (45%), Gaps = 32/476 (6%)
Query: 999 LHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDAT 1058
LHLAA +G+ ++ L++ +DV +TPL LAA G +E +L+ GA+I
Sbjct: 21 LHLAAYHGHHQALEVLVQSL-LDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVK 79
Query: 1059 DE-LGQKPIHAAAQNNYSEVVQLFL--QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEEL 1115
D L + PIHAAA N +SE ++L + + N V +G T ++ + G + L
Sbjct: 80 DYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSL 139
Query: 1116 MKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEH 1175
+ ++ + A++K T L A GH + V L++ GA C + G T +HL+A
Sbjct: 140 L--NKGANVDAKDKWG-RTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAAC 196
Query: 1176 GHTNVLDVM----RSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT 1231
GH VL + S + ++ G T LH A Y G ET ELL K+E
Sbjct: 197 GHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGH-ETCVELLLEQEVFQKTEG-- 253
Query: 1232 GVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGH 1291
+ +PLH A N NE +L+++ G A++ G PLH A F H
Sbjct: 254 -----------NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDH 302
Query: 1292 MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPL 1350
+ + LLLS +A++ +S D GKT L +A+ +G VE+L+ AE+ D + T L
Sbjct: 303 VECLQLLLSHNAQV-NSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTAL 361
Query: 1351 HCAAKAGHLNVVKLLCESGASPKSETNLNCA---PIWFAASENHNDVLEYLLHKEHDTQS 1407
H A GH L+ E N A P+ AA V++ LL K
Sbjct: 362 HLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGK--GASV 419
Query: 1408 LMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKERAK 1463
L D+ + C+ N + +L + PV +++ LS++ N + +K
Sbjct: 420 LAVDENGYTPALACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAINRYTNTSK 475
Score = 132 bits (320), Expect = 1e-29
Identities = 109/358 (30%), Positives = 175/358 (48%), Gaps = 17/358 (4%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
+ V LI GA + ++ T H A G+++ + +I + A+ A++ Q+ G
Sbjct: 64 ECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGN---AEPQNAVDIQDGNG 120
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
TPL+++ GH V +LL A VD D GR+ALH A G+ + DALL + A
Sbjct: 121 QTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCL 180
Query: 990 SKARNGRTALHLAAMNGYAHLVKFLIRDHNAM-IDVLTLKKQ--TPLHLAAASGQIEVCK 1046
+ GRT +HL+A G+ ++ L++ +M + T T LH A +G +
Sbjct: 181 LRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVE 240
Query: 1047 LLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ-HPNLVMATTKDGNTCAHIAAI 1105
LLLE T+ P+H A N+ ++ + ++V AT G T H AA
Sbjct: 241 LLLEQEV-FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAF 299
Query: 1106 QGSVKVIEELMKFD-RTGVISARNKLNDSTPLQLAAEGGHADVVRVLV-RAGASCTDENR 1163
V+ ++ L+ + + + + K TPL +AAE G + V +LV A A T ++
Sbjct: 300 TDHVECLQLLLSHNAQVNSVDSTGK----TPLMMAAENGQTNTVEMLVSSASAELTLQDN 355
Query: 1164 AGLTAVHLAAEHGH-TNVLDVM-RSTNTLRISSKKLGL-TPLHIAAYYGQAETVRELL 1218
+ TA+HLA GH T+ L ++ + T+ I++ L TPLH+AA G V+ELL
Sbjct: 356 SKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELL 413
Score = 119 bits (287), Expect = 1e-25
Identities = 126/434 (29%), Positives = 197/434 (45%), Gaps = 46/434 (10%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA +GH + L+Q +DV + T L +A V+ L+ GA + ++
Sbjct: 21 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 80
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATE----DGMTPVHVAAKFGNLATLVL 782
+ TP+H AA +G L LL A P A + +G TP+ ++ G+ +
Sbjct: 81 YILKRTPIHAAA--TNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 138
Query: 783 LLEDGGDPLRKTK---VCIY-DVVTG-----ETPLQMACRSCMPDIVRHL---IEFVKDH 830
LL G + K K ++ VTG + LQ + + D + H
Sbjct: 139 LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGH 198
Query: 831 KGE----SVSTAFIDA----VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
G S A +DA D G +ALH+AC V+ L+E +V
Sbjct: 199 IGVLGALLQSAASMDANPATADNHGYTALHWACY---------NGHETCVELLLEQ--EV 247
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+T N + H CA+ +N+ EM+ I T S +N +S G TPL A H+
Sbjct: 248 FQKTEGNAFSPLH-CAVINDNEGAAEML--IDTLGAS-IVNATDSKGRTPLHAAAFTDHV 303
Query: 943 QLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTN-KAFINSKARNGRTALHL 1001
+ + LL+++A+V+ D G++ L +AAE+G + L+++ A + + + TALHL
Sbjct: 304 ECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHL 363
Query: 1002 AAMNGY---AHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDAT 1058
A G+ A L+ I D N +I+ QTPLH+AA +G V + LL GA++ A
Sbjct: 364 ACSKGHETSALLILEKITDRN-LINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAV 422
Query: 1059 DELGQKPIHAAAQN 1072
DE G P A A N
Sbjct: 423 DENGYTPALACAPN 436
Score = 72.9 bits (171), Expect = 1e-11
Identities = 51/174 (29%), Positives = 79/174 (45%), Gaps = 6/174 (3%)
Query: 54 LIRDLVFQRGKVPLLLAVEAGNQSMVRELL-SAQTAEQLKATTPAGDTALHLAARRRDVD 112
L++D + +R P+ A G+ +R L+ +A+ + G T L L+ D
Sbjct: 77 LVKDYILKR--TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTD 134
Query: 113 MARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA 172
L++ GA VDA + G+T LH A G E V A + D+ RTP+HL+A
Sbjct: 135 CVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSA 194
Query: 173 ENGHAAIIELL---ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
GH ++ L A A+ G T +H A NGH C +L ++ V+
Sbjct: 195 ACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVF 248
Score = 71.7 bits (168), Expect = 3e-11
Identities = 75/230 (32%), Positives = 106/230 (46%), Gaps = 26/230 (11%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDV--TTNDN--YTALHIAVESCKPAVVETLLGY 718
G IH +A GH+G++ LLQ S+D T DN YTALH A + VE LL
Sbjct: 186 GRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLL-- 243
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKS-GAGPNKATED-GMTPVHVAAKFGN 776
+V + +PLH A I D + A ML+ + GA AT+ G TP+H AA +
Sbjct: 244 EQEVFQKTEGNAFSPLHCAV-INDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDH 302
Query: 777 LATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVS 836
+ L LLL +V D TG+TPL MA + + V L+ S +
Sbjct: 303 VECLQLLLS------HNAQVNSVD-STGKTPLMMAAENGQTNTVEMLV---------SSA 346
Query: 837 TAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQT 886
+A + D +ALH AC E + ++ + LI N + +LQT
Sbjct: 347 SAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLI-NATNAALQT 395
Score = 68.1 bits (159), Expect = 3e-10
Identities = 48/160 (30%), Positives = 77/160 (48%), Gaps = 5/160 (3%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVD-YG 121
G L A G+++ V ELL Q E + T + LH A + A +L+D G
Sbjct: 223 GYTALHWACYNGHETCV-ELLLEQ--EVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLG 279
Query: 122 A-VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A +V+AT+ G+TPLH AA ++ A D+ +TP+ +AAENG +
Sbjct: 280 ASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTV 339
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
E+L A + + +T +H+A GH A+++ +K
Sbjct: 340 EMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEK 379
Score = 67.7 bits (158), Expect = 4e-10
Identities = 43/132 (32%), Positives = 63/132 (47%), Gaps = 3/132 (2%)
Query: 102 LHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIAD 161
LHLAA +LV +D N +G+TPL +AA +G V A+ + D
Sbjct: 21 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 80
Query: 162 N-EDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGS--TLMHIASLNGHADCAMMLF 218
RTP+H AA NGH+ + LL + +DG+ T + ++ LNGH DC L
Sbjct: 81 YILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLL 140
Query: 219 KKGVYLHMPNKY 230
KG + +K+
Sbjct: 141 NKGANVDAKDKW 152
Score = 61.7 bits (143), Expect = 3e-08
Identities = 41/119 (34%), Positives = 61/119 (51%), Gaps = 4/119 (3%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
GK PL++A E G + V L+S+ +AE L + +TALHLA + A ++++
Sbjct: 323 GKTPLMMAAENGQTNTVEMLVSSASAE-LTLQDNSKNTALHLACSKGHETSALLILEKIT 381
Query: 123 ---VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
+++ATN A QTPLH+AA G +V+ G A+ D TP A N A
Sbjct: 382 DRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVA 440
Score = 58.0 bits (134), Expect = 3e-07
Identities = 34/96 (35%), Positives = 53/96 (55%), Gaps = 1/96 (1%)
Query: 1305 LLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKL 1364
L S +R + LH+A+ HGH+Q +EVL+ +++ + +G TPL AA GH+ V +
Sbjct: 9 LSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDV 68
Query: 1365 LCESGAS-PKSETNLNCAPIWFAASENHNDVLEYLL 1399
L GAS + L PI AA+ H++ L L+
Sbjct: 69 LINQGASILVKDYILKRTPIHAAATNGHSECLRLLI 104
Score = 51.2 bits (117), Expect = 4e-05
Identities = 26/93 (27%), Positives = 49/93 (52%)
Query: 125 DATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
D+ N A +PLH+AA G ++ + + ++ RTP+ LAA GH +++L
Sbjct: 11 DSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLI 70
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
++ + + + T +H A+ NGH++C +L
Sbjct: 71 NQGASILVKDYILKRTPIHAAATNGHSECLRLL 103
Score = 42.7 bits (96), Expect = 0.014
Identities = 42/161 (26%), Positives = 70/161 (43%), Gaps = 8/161 (4%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G+ PL A + ++ LLS Q+ + G T L +AA + +LV
Sbjct: 289 KGRTPLHAAAFTDHVECLQLLLSHNA--QVNSVDSTGKTPLMMAAENGQTNTVEMLVSSA 346
Query: 122 -AVVDATNGAGQTPLHIAAAEGDEPLVKYFYG--VRANAAIADNED-RTPMHLAAENGHA 177
A + + + T LH+A ++G E N A N +TP+H+AA NG
Sbjct: 347 SAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLT 406
Query: 178 AIIELLADKFKASIFERTKDGST-LMHIASLNGHADCAMML 217
+++ L K AS+ ++G T + A ADC ++
Sbjct: 407 MVVQELLGK-GASVLAVDENGYTPALACAPNKDVADCLALI 446
Score = 41.5 bits (93), Expect = 0.031
Identities = 78/354 (22%), Positives = 136/354 (38%), Gaps = 35/354 (9%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H A GH ++ LLQ G + + T +H++ V+ LL A +
Sbjct: 153 GRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASM 212
Query: 723 HIR---GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
T LH A +G + + LL K + +P+H A N
Sbjct: 213 DANPATADNHGYTALHWACY--NGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGA 270
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF 839
+L+ D L + V D G TPL A D V ++ + H +
Sbjct: 271 AEMLI----DTLGASIVNATD-SKGRTPLHAA---AFTDHV-ECLQLLLSHNAQ------ 315
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIEN-GADVSLQTRHNHETAFHYCA 898
+++VD G + L A + V+ L+ + A+++LQ ++ TA H
Sbjct: 316 VNSVDSTGKTPLMMAAE---------NGQTNTVEMLVSSASAELTLQD-NSKNTALHLAC 365
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVF 958
G+ ++ I+ ++ +N N+ TPL +A G +V LL A V
Sbjct: 366 SKGHETSALLILEKITDRNL---INATNAALQTPLHVAARNGLTMVVQELLGKGASVLAV 422
Query: 959 DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVK 1012
D G + A + + C AL+ + + + ++L A+N Y + K
Sbjct: 423 DENGYTPALACAPNKDVADCLALIL-ATMMPVSSSSPLSSLTFNAINRYTNTSK 475
>BC063622-1|AAH63622.1| 367|Homo sapiens ANKRD44 protein protein.
Length = 367
Score = 171 bits (417), Expect = 2e-41
Identities = 114/349 (32%), Positives = 178/349 (51%), Gaps = 19/349 (5%)
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
++ L +K+TPLH+AA G E+ +LL+ GA ++A D + P+H A + E VQ+
Sbjct: 34 VNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVL 93
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
++ H V A K+ T H+AA +VK E ++ + +S R T L AA
Sbjct: 94 IK-HSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRG---GRTALHHAAL 149
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTP 1201
GH ++V +L+ GA+ ++ A+H AA GH +V+ ++ + K G TP
Sbjct: 150 NGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTP 209
Query: 1202 LHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVR 1261
LH AA GQ V+ LL+ GV + + G T LH+A YNG + VV
Sbjct: 210 LHAAASNGQINVVKHLLN-----------LGVEIDEI--NVYGNTALHIACYNGQDAVVN 256
Query: 1262 LLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIAS 1321
L++ G + +N NG+ PLH A H ++ LL + ++ + GK+ LH+ +
Sbjct: 257 ELIDY-GANVNQPNN-NGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTA 314
Query: 1322 THGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
HG + + L+ G EI+ DK+G TPLH AA+ GH ++ L SGA
Sbjct: 315 VHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLITSGA 363
Score = 140 bits (340), Expect = 4e-32
Identities = 114/384 (29%), Positives = 179/384 (46%), Gaps = 23/384 (5%)
Query: 1024 VLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
VL L Q PL A SG E ++L+ +++ D + P+H AA +E+++L +
Sbjct: 3 VLKLTDQPPLVQAIFSGDPEEIRMLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLIL 62
Query: 1084 QHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGG 1143
V A T H A S + ++ L+K + ++AR+K N TPL +AA
Sbjct: 63 SGAR-VNAKDNMWLTPLHRAVASRSEEAVQVLIK--HSADVNARDK-NWQTPLHVAAANK 118
Query: 1144 HADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLH 1203
V++ +S +R G TA+H AA +GH +++++ + + K LH
Sbjct: 119 AVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALH 178
Query: 1204 IAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLL 1263
AAY G + V L++H + + G TPLH AA NG NVV+ L
Sbjct: 179 WAAYMGHLDVVALLINHGAEVTCKD-------------KKGYTPLHAAASNGQINVVKHL 225
Query: 1264 LNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIA--S 1321
LN GV+ D N G LH+AC+ G ++V L+ A + + + +G T LH A S
Sbjct: 226 LN-LGVEIDEI-NVYGNTALHIACYNGQDAVVNELIDYGANV-NQPNNNGFTPLHFAAAS 282
Query: 1322 THGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCA 1381
THG +E+L+ GA++N K+G +PLH A G + L ++G
Sbjct: 283 THGAL-CLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNT 341
Query: 1382 PIWFAASENHNDVLEYLLHKEHDT 1405
P+ AA H ++ L+ DT
Sbjct: 342 PLHVAARYGHELLINTLITSGADT 365
Score = 140 bits (340), Expect = 4e-32
Identities = 106/363 (29%), Positives = 173/363 (47%), Gaps = 15/363 (4%)
Query: 866 TADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQ 925
+ D + ++ LI DV+ T H A G+ +++ +I +S A V N +
Sbjct: 18 SGDPEEIRMLIHKTEDVNTLDSEKR-TPLHVAAFLGDAEIIELLI--LSGARV----NAK 70
Query: 926 NSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNK 985
+++ TPL A + V L+ + A V+ D ++ LH+AA + ++ + ++
Sbjct: 71 DNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLL 130
Query: 986 AFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVC 1045
+ +N R GRTALH AA+NG+ +V L+ A I+ K + LH AA G ++V
Sbjct: 131 SSVNVSDRGGRTALHHAALNGHVEMVNLLLAK-GANINAFDKKDRRALHWAAYMGHLDVV 189
Query: 1046 KLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAI 1105
LL+ GA + D+ G P+HAAA N VV+ L + GNT HIA
Sbjct: 190 ALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVY-GNTALHIACY 248
Query: 1106 QGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADV-VRVLVRAGASCTDENRA 1164
G V+ EL+ + ++ N N TPL AA H + + +LV GA +++
Sbjct: 249 NGQDAVVNELIDYGAN--VNQPNN-NGFTPLHFAAASTHGALCLELLVNNGADVNIQSKD 305
Query: 1165 GLTAVHLAAEHGH-TNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPG 1223
G + +H+ A HG T ++++ + K G TPLH+AA YG + L++
Sbjct: 306 GKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKD-GNTPLHVAARYGHELLINTLITSGAD 364
Query: 1224 TVK 1226
T K
Sbjct: 365 TAK 367
Score = 138 bits (334), Expect = 2e-31
Identities = 104/373 (27%), Positives = 181/373 (48%), Gaps = 19/373 (5%)
Query: 932 PLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSK 991
PL+ A G + + L+ V+ D E R+ LH+AA G ++ + L+ + A +N+K
Sbjct: 11 PLVQAIFSGDPEEIRMLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAK 70
Query: 992 ARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLEL 1051
T LH A + V+ LI+ H+A ++ QTPLH+AAA+ ++ ++++ L
Sbjct: 71 DNMWLTPLHRAVASRSEEAVQVLIK-HSADVNARDKNWQTPLHVAAANKAVKCAEVIIPL 129
Query: 1052 GANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKV 1111
++++ +D G+ +H AA N + E+V L L + N+ KD H AA G + V
Sbjct: 130 LSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKD-RRALHWAAYMGHLDV 188
Query: 1112 IEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHL 1171
+ L+ + ++ ++K TPL AA G +VV+ L+ G + N G TA+H+
Sbjct: 189 VALLI--NHGAEVTCKDK-KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHI 245
Query: 1172 AAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT 1231
A +G V++ + G TPLH AA ELL V + A
Sbjct: 246 ACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELL------VNNGADV 299
Query: 1232 GVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGH 1291
+ ++ G +PLH+ A +G + L+ + G + D +++G PLH+A GH
Sbjct: 300 NIQ------SKDGKSPLHMTAVHGRFTRSQTLIQNGG-EIDCV-DKDGNTPLHVAARYGH 351
Query: 1292 MSIVGLLLSRSAE 1304
++ L++ A+
Sbjct: 352 ELLINTLITSGAD 364
Score = 128 bits (310), Expect = 2e-28
Identities = 111/383 (28%), Positives = 184/383 (48%), Gaps = 30/383 (7%)
Query: 802 VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEE 861
+T + PL A S P+ +R LI HK E V+T +D + + LH A +
Sbjct: 6 LTDQPPLVQAIFSGDPEEIRMLI-----HKTEDVNT-----LDSEKRTPLHVAAFL---- 51
Query: 862 VKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRA 921
D ++++ LI +GA V+ + + T H + + + + +I H +ADV
Sbjct: 52 -----GDAEIIELLILSGARVNAKD-NMWLTPLHRAVASRSEEAVQVLIKH--SADV--- 100
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
N ++ TPL +A ++ ++ + V+V D GR+ALH AA +G++++ + L
Sbjct: 101 -NARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLL 159
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
L A IN+ + R ALH AA G+ +V LI +H A + K TPLH AA++GQ
Sbjct: 160 LAKGANINAFDKKDRRALHWAAYMGHLDVVALLI-NHGAEVTCKDKKGYTPLHAAASNGQ 218
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAH 1101
I V K LL LG ID + G +H A N VV + N V +G T H
Sbjct: 219 INVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN-VNQPNNNGFTPLH 277
Query: 1102 IAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDE 1161
AA + EL+ + ++ ++K + +PL + A G + L++ G
Sbjct: 278 FAAASTHGALCLELL-VNNGADVNIQSK-DGKSPLHMTAVHGRFTRSQTLIQNGGEIDCV 335
Query: 1162 NRAGLTAVHLAAEHGHTNVLDVM 1184
++ G T +H+AA +GH +++ +
Sbjct: 336 DKDGNTPLHVAARYGHELLINTL 358
Score = 118 bits (283), Expect = 3e-25
Identities = 98/380 (25%), Positives = 176/380 (46%), Gaps = 35/380 (9%)
Query: 703 AVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATE 762
A+ S P + L+ DV+ ++R TPLH+AA + D + L++L SGA N
Sbjct: 15 AIFSGDPEEIRMLIHKTEDVNTLDSEKR-TPLHVAAFLGDAEIIELLIL-SGARVNAKDN 72
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
+TP+H A + + +L++ D + K +TPL +A +
Sbjct: 73 MWLTPLHRAVASRSEEAVQVLIKHSADVNARDK-------NWQTPLHVAAANKAVKCAEV 125
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
+I + ++ D G +ALH+A ++V L+ GA++
Sbjct: 126 IIPLLSS----------VNVSDRGGRTALHHAAL---------NGHVEMVNLLLAKGANI 166
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ + + A H+ A G+ DV+ +I H A+V+ ++ G+TPL A G +
Sbjct: 167 NAFDKKDRR-ALHWAAYMGHLDVVALLINH--GAEVTC----KDKKGYTPLHAAASNGQI 219
Query: 943 QLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLA 1002
+V LL +D +V G +ALH+A +G V + L+ A +N NG T LH A
Sbjct: 220 NVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFA 279
Query: 1003 AMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELG 1062
A + + L L+ ++ A +++ + ++PLH+ A G+ + L++ G ID D+ G
Sbjct: 280 AASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDG 339
Query: 1063 QKPIHAAAQNNYSEVVQLFL 1082
P+H AA+ + ++ +
Sbjct: 340 NTPLHVAARYGHELLINTLI 359
Score = 96.7 bits (230), Expect = 8e-19
Identities = 105/377 (27%), Positives = 176/377 (46%), Gaps = 37/377 (9%)
Query: 679 INTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAA 738
I L+ K E V+ ++ T LH+A ++E L+ GA V+ + TPLH A
Sbjct: 24 IRMLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWL-TPLHRAV 82
Query: 739 RIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCI 798
++ +L+K A N ++ TP+HVAA + +++ PL + V +
Sbjct: 83 -ASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVII-----PL-LSSVNV 135
Query: 799 YDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVT 858
D G T L A + ++V L+ KG A I+A D+ ALH+A +
Sbjct: 136 SD-RGGRTALHHAALNGHVEMVNLLLA-----KG-----ANINAFDKKDRRALHWAAYM- 183
Query: 859 KEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADV 918
VV LI +GA+V+ + + + T H A A N + ++ H+ V
Sbjct: 184 --------GHLDVVALLINHGAEVTCKDKKGY-TPLH--AAASNGQI--NVVKHLLNLGV 230
Query: 919 SRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVC 978
++ N G T L IAC+ G +VN L+ A V+ + G + LH AA + +C
Sbjct: 231 E--IDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALC 288
Query: 979 -DALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAA 1037
+ L+ N A +N ++++G++ LH+ A++G + LI+ + ID + TPLH+AA
Sbjct: 289 LELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQ-NGGEIDCVDKDGNTPLHVAA 347
Query: 1038 ASGQIEVCKLLLELGAN 1054
G + L+ GA+
Sbjct: 348 RYGHELLINTLITSGAD 364
Score = 95.1 bits (226), Expect = 2e-18
Identities = 99/346 (28%), Positives = 159/346 (45%), Gaps = 53/346 (15%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA G II L+ G V+ N T LH AV S V+ L+ + ADV+ R
Sbjct: 45 LHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARD 104
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
K +TPLH+AA KCA +++ + N + G T +H AA G++ + LLL
Sbjct: 105 -KNWQTPLHVAAA-NKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAK 162
Query: 787 GGDPL---RKTKVCIY--------DVVT---------------GETPLQMACRSCMPDIV 820
G + +K + ++ DVV G TPL A + ++V
Sbjct: 163 GANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVV 222
Query: 821 RHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGA 880
+HL+ + ID ++ G +ALH AC ++ V V LI+ GA
Sbjct: 223 KHLLNLGVE----------IDEINVYGNTALHIACYNGQDAV---------VNELIDYGA 263
Query: 881 DVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRG 940
+V+ Q +N T H+ A + + + E++ + + ADV N Q+ G +PL + G
Sbjct: 264 NVN-QPNNNGFTPLHFAAASTHGALCLELLVN-NGADV----NIQSKDGKSPLHMTAVHG 317
Query: 941 HMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKA 986
TL+ N +D D +G + LH+AA +G+ + + L+T+ A
Sbjct: 318 RFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLITSGA 363
Score = 83.0 bits (196), Expect = 1e-14
Identities = 57/210 (27%), Positives = 108/210 (51%), Gaps = 6/210 (2%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
TPLH+AA+ G+ ++ LL+ S G + +A N PLH A V +L+ SA+
Sbjct: 43 TPLHVAAFLGDAEIIELLILS-GARVNAKDN-MWLTPLHRAVASRSEEAVQVLIKHSAD- 99
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
+++ D++ +T LH+A+ + + EV++ + +N +D+ G T LH AA GH+ +V LL
Sbjct: 100 VNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLL 159
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNH 1425
GA+ + + + +AA H DV+ L++ H + DK+ Y + + ++
Sbjct: 160 LAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN--HGAEVTCKDKK-GYTPLHAAASN 216
Query: 1426 NNIPIEEFVLVSPAPVDTAAKLSNIYINLS 1455
I + + +L +D N ++++
Sbjct: 217 GQINVVKHLLNLGVEIDEINVYGNTALHIA 246
Score = 81.0 bits (191), Expect = 4e-14
Identities = 51/151 (33%), Positives = 76/151 (50%), Gaps = 8/151 (5%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA G + ++ LL G +D TALHIA + + AVV L+ YGA+V
Sbjct: 206 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 265
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + TPLH AA G C +L+ +GA N ++DG +P+H+ A G
Sbjct: 266 N-QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQT 324
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACR 813
L+++GG+ + D G TPL +A R
Sbjct: 325 LIQNGGE------IDCVD-KDGNTPLHVAAR 348
Score = 70.1 bits (164), Expect = 8e-11
Identities = 41/128 (32%), Positives = 71/128 (55%), Gaps = 3/128 (2%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAV-VETLLGYGAD 721
G ++H A G ++N L+ G +V+ N+ +T LH A S A+ +E L+ GAD
Sbjct: 239 GNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGAD 298
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V+I+ K ++PLH+ A + + L+++G + +DG TP+HVAA++G+ +
Sbjct: 299 VNIQS-KDGKSPLHMTA-VHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLIN 356
Query: 782 LLLEDGGD 789
L+ G D
Sbjct: 357 TLITSGAD 364
Score = 69.7 bits (163), Expect = 1e-10
Identities = 48/165 (29%), Positives = 78/165 (47%), Gaps = 3/165 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL AV + ++ V+ L+ + + + A T LH+AA + V A +++ + V+
Sbjct: 77 PLHRAVASRSEEAVQVLI--KHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVN 134
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
++ G+T LH AA G +V AN D +DR +H AA GH ++ LL +
Sbjct: 135 VSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 194
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
A + + K G T +H A+ NG + L GV + N Y
Sbjct: 195 H-GAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVY 238
Score = 69.7 bits (163), Expect = 1e-10
Identities = 48/168 (28%), Positives = 81/168 (48%), Gaps = 4/168 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L A G+ MV LL+ + A ALH AA +D+ +L+++GA
Sbjct: 140 GRTALHHAALNGHVEMVNLLLAK--GANINAFDKKDRRALHWAAYMGHLDVVALLINHGA 197
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V + G TPLH AA+ G +VK+ + + T +H+A NG A++
Sbjct: 198 EVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNE 257
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGH-ADCAMMLFKKGVYLHMPNK 229
L D + A++ + +G T +H A+ + H A C +L G +++ +K
Sbjct: 258 LID-YGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSK 304
Score = 68.9 bits (161), Expect = 2e-10
Identities = 49/166 (29%), Positives = 79/166 (47%), Gaps = 3/166 (1%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL +A G+ ++ ELL A ++ A T LH A R + ++L+ + A
Sbjct: 42 RTPLHVAAFLGDAEII-ELLILSGA-RVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSAD 99
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
V+A + QTPLH+AAA + + ++ ++D RT +H AA NGH ++ LL
Sbjct: 100 VNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLL 159
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
K A+I K +H A+ GH D +L G + +K
Sbjct: 160 LAK-GANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 204
Score = 68.9 bits (161), Expect = 2e-10
Identities = 39/125 (31%), Positives = 65/125 (52%), Gaps = 2/125 (1%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G T LH AA +++ + L++ G +D N G T LHIA G + +V AN
Sbjct: 206 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 265
Query: 158 AIADNEDRTPMHLAAENGHAAI-IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMM 216
+N TP+H AA + H A+ +ELL + A + ++KDG + +H+ +++G +
Sbjct: 266 NQPNNNGFTPLHFAAASTHGALCLELLVNN-GADVNIQSKDGKSPLHMTAVHGRFTRSQT 324
Query: 217 LFKKG 221
L + G
Sbjct: 325 LIQNG 329
Score = 67.7 bits (158), Expect = 4e-10
Identities = 46/151 (30%), Positives = 73/151 (48%), Gaps = 4/151 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL A G ++V+ LL+ ++ G+TALH+A + L+DY
Sbjct: 204 KKGYTPLHAAASNGQINVVKHLLNLGV--EIDEINVYGNTALHIACYNGQDAVVNELIDY 261
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPL-VKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
GA V+ N G TPLH AAA L ++ A+ I + ++P+H+ A +G
Sbjct: 262 GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR 321
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGH 210
+ L I KDG+T +H+A+ GH
Sbjct: 322 SQTLIQN-GGEIDCVDKDGNTPLHVAARYGH 351
Score = 64.1 bits (149), Expect = 5e-09
Identities = 46/160 (28%), Positives = 70/160 (43%), Gaps = 1/160 (0%)
Query: 69 LAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATN 128
L V A N+++ + + + G TALH AA V+M +L+ GA ++A +
Sbjct: 111 LHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFD 170
Query: 129 GAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFK 188
+ LH AA G +V A D + TP+H AA NG +++ L +
Sbjct: 171 KKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLN-LG 229
Query: 189 ASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
I E G+T +HIA NG L G ++ PN
Sbjct: 230 VEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 269
Score = 54.8 bits (126), Expect = 3e-06
Identities = 63/244 (25%), Positives = 104/244 (42%), Gaps = 26/244 (10%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H AA GHV ++N LL KG +++ + ALH A VV L+ +GA+V
Sbjct: 140 GRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEV 199
Query: 723 HIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ K+ TPLH AA +G LL G ++ G T +H+A G A +
Sbjct: 200 TCK-DKKGYTPLHAAA--SNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVN 256
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
L++ G + + G TPL A S + L+ + G A ++
Sbjct: 257 ELIDYGANVNQPNN-------NGFTPLHFAAASTHGALCLELLV----NNG-----ADVN 300
Query: 842 AVDEDGASALHYAC---KVTKEEVKIPTADRQVVKCLIENG-ADVSLQTRHNHETAFHYC 897
+DG S LH + T+ + I + C+ ++G + + R+ HE +
Sbjct: 301 IQSKDGKSPLHMTAVHGRFTRSQTLIQNGGE--IDCVDKDGNTPLHVAARYGHELLINTL 358
Query: 898 AIAG 901
+G
Sbjct: 359 ITSG 362
Score = 51.2 bits (117), Expect = 4e-05
Identities = 33/110 (30%), Positives = 55/110 (50%), Gaps = 5/110 (4%)
Query: 110 DVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTP 167
D + R+L+ V+ + +TPLH+AA GD +++ G R NA DN TP
Sbjct: 20 DPEEIRMLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNA--KDNMWLTP 77
Query: 168 MHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+H A + +++L K A + R K+ T +H+A+ N CA ++
Sbjct: 78 LHRAVASRSEEAVQVLI-KHSADVNARDKNWQTPLHVAAANKAVKCAEVI 126
Score = 46.8 bits (106), Expect = 8e-04
Identities = 34/122 (27%), Positives = 52/122 (42%), Gaps = 3/122 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMA-RILVDYG 121
G L +A G ++V EL+ + G T LH AA + +LV+ G
Sbjct: 239 GNTALHIACYNGQDAVVNELIDY--GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNG 296
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE 181
A V+ + G++PLH+ A G + D + TP+H+AA GH +I
Sbjct: 297 ADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLIN 356
Query: 182 LL 183
L
Sbjct: 357 TL 358
Score = 44.4 bits (100), Expect = 0.004
Identities = 26/101 (25%), Positives = 48/101 (47%), Gaps = 2/101 (1%)
Query: 1324 GHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPI 1383
G + + +L+ + ++N D TPLH AA G +++LL SGA ++ N+ P+
Sbjct: 19 GDPEEIRMLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPL 78
Query: 1384 WFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKN 1424
A + + ++ L+ +H DK + L V + N
Sbjct: 79 HRAVASRSEEAVQVLI--KHSADVNARDKNWQTPLHVAAAN 117
Score = 41.1 bits (92), Expect = 0.041
Identities = 20/60 (33%), Positives = 28/60 (46%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DG +H A +G TL+Q G +D D T LH+A ++ TL+ GAD
Sbjct: 305 DGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLITSGAD 364
Score = 36.7 bits (81), Expect = 0.89
Identities = 21/52 (40%), Positives = 27/52 (51%)
Query: 132 QTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
Q PL A GD ++ + D+E RTP+H+AA G A IIELL
Sbjct: 9 QPPLVQAIFSGDPEEIRMLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELL 60
>AL359707-2|CAC78760.1| 1166|Homo sapiens tankyrase, TRF1-interacting
ankyrin-related ADP-ribose polymerase 2 protein.
Length = 1166
Score = 170 bits (413), Expect = 5e-41
Identities = 199/761 (26%), Positives = 321/761 (42%), Gaps = 60/761 (7%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA +G ++ LLQ G +V + LH A VV LL +GAD + R
Sbjct: 62 LHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARD 121
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
TPLH AA D C ++LL+ GA P DG T + +A A VL E
Sbjct: 122 N-WNYTPLHEAAIKGKIDVC-IVLLQHGAEPTIRNTDGRTALDLADPS---AKAVLTGEY 176
Query: 787 GGDPLRKTKVCIYD--VVTGETPLQMAC-----RSCMPDIVRHLIEFVKDHKGESVSTAF 839
D L ++ + ++ TPL + C R P + VK + A
Sbjct: 177 KKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGAD 236
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+ A D+ LH AC EV + L+++GA V+ T H A
Sbjct: 237 VHAKDKGDLVPLHNACSYGHYEV---------TELLVKHGACVNAMDLWQF-TPLHEAAS 286
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQN-SIGWTPLL---IACH-RGHMQLVN------TL 948
+V + ++++ + + N+ + TP L +A +GH L T
Sbjct: 287 KNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTR 346
Query: 949 LTNHARVDVFDVEG----RSALHLAAEHGY---LQVCDALLTNKAFINSKARNGRTALHL 1001
+ H +++ + + +ALH AA Y Q+C+ LL A IN K + T LH+
Sbjct: 347 IKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHV 406
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A+ + +V+ +++ H A ++ L QT LH AA G ++ C+LLL G + +
Sbjct: 407 ASEKAHNDVVEVVVK-HEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQ 465
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
G + +N VQ LQ+ +L + + AA G V+ +++L
Sbjct: 466 GFTALQMGNEN-----VQQLLQEGISL---GNSEADRQLLEAAKAGDVETVKKLCTVQSV 517
Query: 1122 GVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVL 1181
+ STPL AA VV L++ GA +++ GL +H A +GH V
Sbjct: 518 NCRDIEGR--QSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVA 575
Query: 1182 DVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGA 1241
+++ + + TPLH AA G+ E + LL H K L V
Sbjct: 576 ELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDG 635
Query: 1242 ESGLTPLHL-------AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSI 1294
++ + L AA G V+ L + V + PLHLA ++ +
Sbjct: 636 DTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHS-TPLHLAAGYNNLEV 694
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
LL A++ ++ D+ G LH A+++GH + +L+ A +NATDK +TPLH AA
Sbjct: 695 AEYLLQHGADV-NAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAA 753
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVL 1395
+ G + LL GA P + P+ ++++ + +L
Sbjct: 754 QKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794
Score = 150 bits (363), Expect = 6e-35
Identities = 163/618 (26%), Positives = 259/618 (41%), Gaps = 79/618 (12%)
Query: 806 TPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIP 865
TPL A D+V +L++ + A + A D+ G LH AC EV
Sbjct: 60 TPLHFAAGFGRKDVVEYLLQ----------NGANVQARDDGGLIPLHNACSFGHAEV--- 106
Query: 866 TADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAH------------- 912
V L+ +GAD + + N+ T H AI G DV ++ H
Sbjct: 107 ------VNLLLRHGADPNARDNWNY-TPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRT 159
Query: 913 -ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSA--LHLA 969
+ AD S LL + G+ + + LLT V+ +GR + LHLA
Sbjct: 160 ALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLA 218
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKK 1029
A + +++ LL + A +++K + LH A G+ + + L++ H A ++ + L +
Sbjct: 219 AGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK-HGACVNAMDLWQ 277
Query: 1030 QTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
TPLH AA+ ++EVC LLL GA+ + + I A E + + H L
Sbjct: 278 FTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQ 337
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA---D 1146
A D + + K +++ ++ T L AA +
Sbjct: 338 AAREAD----------------VTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQ 381
Query: 1147 VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
+ +L+R GA+ ++ + LT +H+A+E H +V++V+ + LG T LH AA
Sbjct: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS 1266
Y G +T R LLS+ P +SL G T L + GNENV +LL
Sbjct: 442 YCGHLQTCRLLLSY------GCDPNIISL-------QGFTALQM----GNENVQQLL--Q 482
Query: 1267 AGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHY 1326
G+ + N L A G + V L + + + T LH A+ +
Sbjct: 483 EGI---SLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRV 539
Query: 1327 QMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFA 1386
+VE LL GA+++A DK G PLH A GH V +LL + GA P+ A
Sbjct: 540 SVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEA 599
Query: 1387 ASENHNDVLEYLLHKEHD 1404
A++ ++ + LL D
Sbjct: 600 AAKGKYEICKLLLQHGAD 617
Score = 146 bits (354), Expect = 7e-34
Identities = 199/746 (26%), Positives = 322/746 (43%), Gaps = 112/746 (15%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H A +GH ++N LL+ G + N NYT LH A K V LL +GA+
Sbjct: 91 GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 150
Query: 723 HIRG-------------------GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATED 763
IR G+ ++ L +AR G++ +M L + N D
Sbjct: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESAR--SGNEEKMMALLTPLNVNCHASD 208
Query: 764 G--MTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVR 821
G TP+H+AA + + + LLL+ G D K K D+V PL AC ++
Sbjct: 209 GRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDK---GDLV----PLHNACSYGHYEVTE 261
Query: 822 HLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEV----KIPTADRQVVKCLIE 877
L++ A ++A+D + LH A + EV AD ++ C +
Sbjct: 262 LLVK----------HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNK 311
Query: 878 NGADVS----LQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPL 933
+ D++ L+ R +E H A +T + H+S V+ + +
Sbjct: 312 SAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCA 371
Query: 934 LIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKAR 993
+ + Q+ LL A ++ E + LH+A+E + V + ++ ++A +N+
Sbjct: 372 AASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDN 431
Query: 994 NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHL------------------ 1035
G+T+LH AA G+ + L+ + ++++L+ T L +
Sbjct: 432 LGQTSLHRAAYCGHLQTCRLLL-SYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNS 490
Query: 1036 --------AAASGQIEVCKLLLELGANIDATDELGQK--PIHAAAQNNYSEVVQLFLQQH 1085
AA +G +E K L + +++ D G++ P+H AA N VV+ +L QH
Sbjct: 491 EADRQLLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVE-YLLQH 548
Query: 1086 PNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA 1145
V A K G H A G +V E L+K G + L TPL AA G
Sbjct: 549 GADVHAKDKGGLVPLHNACSYGHYEVAELLVKH---GAVVNVADLWKFTPLHEAAAKGKY 605
Query: 1146 DVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIA 1205
++ ++L++ GA T +NR G T + L + G T++ D++R L ++KK
Sbjct: 606 EICKLLLQHGADPTKKNRDGNTPLDLVKD-GDTDIQDLLRGDAALLDAAKK--------- 655
Query: 1206 AYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA-YNGNENVVRLLL 1264
G V++L S P V+ G S TPLHLAA YN E LL
Sbjct: 656 ---GCLARVKKLSS----------PDNVNCRDTQGRHS--TPLHLAAGYNNLEVAEYLLQ 700
Query: 1265 NSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHG 1324
+ A V A ++ G PLH A GH+ + LL+ +A +++TD+ T LH A+ G
Sbjct: 701 HGADVN---AQDKGGLIPLHNAASYGHVDVAALLIKYNA-CVNATDKWAFTPLHEAAQKG 756
Query: 1325 HYQMVEVLLGQGAEINATDKNGWTPL 1350
Q+ +LL GA+ ++ G TPL
Sbjct: 757 RTQLCALLLAHGADPTLKNQEGQTPL 782
Score = 137 bits (332), Expect = 3e-31
Identities = 185/739 (25%), Positives = 304/739 (41%), Gaps = 98/739 (13%)
Query: 729 QRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGG 788
++ TPLH AA D LL++GA + G+ P+H A FG+ + LLL G
Sbjct: 57 RKSTPLHFAAGFGRKDVVEY-LLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGA 115
Query: 789 DPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESV-STAFIDAVDEDG 847
DP + TPL A D+ L++ + + +D D
Sbjct: 116 DPNARDN-------WNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSA 168
Query: 848 ASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMT 907
+ L K + + + + + L+ +V+ ++ + A AG N V
Sbjct: 169 KAVLTGEYKKDELLESARSGNEEKMMALL-TPLNVNCHASDGRKSTPLHLA-AGYNRVKI 226
Query: 908 EMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALH 967
+ ADV A ++ + + PL AC GH ++ L+ + A V+ D+ + LH
Sbjct: 227 VQLLLQHGADV-HAKDKGDLV---PLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLH 282
Query: 968 LAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM-----I 1022
AA ++VC LL+ A + ++A+ LA + + + H+ +
Sbjct: 283 EAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREA 342
Query: 1023 DVLTLKK---------------QTPLHLAAAS---GQIEVCKLLLELGANIDATDELGQK 1064
DV +KK +T LH AAAS + ++C+LLL GANI+ +
Sbjct: 343 DVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLT 402
Query: 1065 PIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFD-RTGV 1123
P+H A++ +++VV++ + +H V A G T H AA G ++ L+ + +
Sbjct: 403 PLHVASEKAHNDVVEVVV-KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
Query: 1124 ISARN----KLNDSTPLQLAAEG---GHADVVRVLVRA----------------GASCTD 1160
IS + ++ + QL EG G+++ R L+ A +C D
Sbjct: 462 ISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRD 521
Query: 1161 ENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSH 1220
T +H AA + +V++ + + K GL PLH A YG E L+ H
Sbjct: 522 IEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKH 581
Query: 1221 VPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGY 1280
G V + A TPLH AA G + +LLL N +G
Sbjct: 582 --GAVVNVADLW-----------KFTPLHEAAAKGKYEICKLLLQHGA--DPTKKNRDGN 626
Query: 1281 NPLHLACFG---------GHMSIVGL----LLSR-----SAELLHSTDRHGK--TGLHIA 1320
PL L G G +++ L+R S + ++ D G+ T LH+A
Sbjct: 627 TPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLA 686
Query: 1321 STHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNC 1380
+ + + ++ E LL GA++NA DK G PLH AA GH++V LL + A +
Sbjct: 687 AGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAF 746
Query: 1381 APIWFAASENHNDVLEYLL 1399
P+ AA + + LL
Sbjct: 747 TPLHEAAQKGRTQLCALLL 765
Score = 116 bits (278), Expect = 1e-24
Identities = 151/557 (27%), Positives = 228/557 (40%), Gaps = 71/557 (12%)
Query: 933 LLIACHRGHMQLVNTLLTNHARVDVFDVEGRSA--LHLAAEHGYLQVCDALLTNKAFINS 990
L AC G ++ V L+T +V+ D GR + LH AA G V + LL N A + +
Sbjct: 28 LFEACRNGDVERVKRLVTPE-KVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQA 86
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
+ G LH A G+A +V L+R H A + TPLH AA G+I+VC +LL+
Sbjct: 87 RDDGGLIPLHNACSFGHAEVVNLLLR-HGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 145
Query: 1051 LGAN--IDATD-----ELGQKPIHAAAQNNYS--EVVQLFLQQHPNLVMAT--------- 1092
GA I TD +L A Y E+++ + +MA
Sbjct: 146 HGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCH 205
Query: 1093 TKDG--NTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRV 1150
DG +T H+AA VK+++ L++ + A++K D PL A GH +V +
Sbjct: 206 ASDGRKSTPLHLAAGYNRVKIVQLLLQHGAD--VHAKDK-GDLVPLHNACSYGHYEVTEL 262
Query: 1151 LVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRS-------TNTLRISSKKLGLTPL- 1202
LV+ GA + T +H AA V ++ S N S+ L TP
Sbjct: 263 LVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQL 322
Query: 1203 -HIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA---YNGNEN 1258
AY + ++ + T + + + +V ++ T LH AA Y +
Sbjct: 323 KERLAYEFKGHSLLQAAREADVT-RIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQ 381
Query: 1259 VVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH 1318
+ LLL G + + E PLH+A H +V +++ A++ ++ D G+T LH
Sbjct: 382 ICELLLRK-GANINEKTKEF-LTPLHVASEKAHNDVVEVVVKHEAKV-NALDNLGQTSLH 438
Query: 1319 IASTHGHYQMVEVLLGQGAEINATDKNGWTPLHC-------------------------- 1352
A+ GH Q +LL G + N G+T L
Sbjct: 439 RAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLE 498
Query: 1353 AAKAGHLNVVKLLCE-SGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDD 1411
AAKAG + VK LC + + P+ FAA N V+EYLL D + D
Sbjct: 499 AAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA-KDK 557
Query: 1412 KRFVYNLMVCSKNHNNI 1428
V CS H +
Sbjct: 558 GGLVPLHNACSYGHYEV 574
Score = 74.5 bits (175), Expect = 4e-12
Identities = 95/382 (24%), Positives = 153/382 (40%), Gaps = 33/382 (8%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G S+H AA GH+ LL G ++ + +TAL + E+ V+ LL G +
Sbjct: 433 GQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGISL 487
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
G + + L AA+ D + + TP+H AA + ++ +
Sbjct: 488 ---GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 544
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFI-- 840
LL+ G D K K G PL AC ++ L++ G V+ A +
Sbjct: 545 LLQHGADVHAKDK-------GGLVPLHNACSYGHYEVAELLVKH-----GAVVNVADLWK 592
Query: 841 -DAVDEDGASALHYACKVTKEEVKIPTA---DRQVVKCLIENGADVSLQTRHNHETAFHY 896
+ E A + CK+ + PT D L+++G D +Q + A
Sbjct: 593 FTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDG-DTDIQDLLRGDAALLD 651
Query: 897 CAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVD 956
A G + +S+ D + Q TPL +A ++++ LL + A V+
Sbjct: 652 AAKKG----CLARVKKLSSPDNVNCRDTQGRHS-TPLHLAAGYNNLEVAEYLLQHGADVN 706
Query: 957 VFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIR 1016
D G LH AA +G++ V L+ A +N+ + T LH AA G L L+
Sbjct: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLA 766
Query: 1017 DHNAMIDVLTLKKQTPLHLAAA 1038
H A + + QTPL L +A
Sbjct: 767 -HGADPTLKNQEGQTPLDLVSA 787
Score = 70.9 bits (166), Expect = 4e-11
Identities = 50/136 (36%), Positives = 64/136 (47%), Gaps = 4/136 (2%)
Query: 1266 SAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGK--TGLHIASTH 1323
+A A A + E L AC G + V L++ E ++S D G+ T LH A+
Sbjct: 11 AACASAAAEAVEPAARELFEACRNGDVERVKRLVT--PEKVNSRDTAGRKSTPLHFAAGF 68
Query: 1324 GHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPI 1383
G +VE LL GA + A D G PLH A GH VV LL GA P + N N P+
Sbjct: 69 GRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPL 128
Query: 1384 WFAASENHNDVLEYLL 1399
AA + DV LL
Sbjct: 129 HEAAIKGKIDVCIVLL 144
Score = 58.0 bits (134), Expect = 3e-07
Identities = 42/129 (32%), Positives = 62/129 (48%), Gaps = 3/129 (2%)
Query: 55 IRDLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMA 114
I+DL+ RG LL A + G + V++L S + T T LHLAA ++++A
Sbjct: 639 IQDLL--RGDAALLDAAKKGCLARVKKLSSPDNVN-CRDTQGRHSTPLHLAAGYNNLEVA 695
Query: 115 RILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAEN 174
L+ +GA V+A + G PLH AA+ G + A D TP+H AA+
Sbjct: 696 EYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQK 755
Query: 175 GHAAIIELL 183
G + LL
Sbjct: 756 GRTQLCALL 764
Score = 55.2 bits (127), Expect = 2e-06
Identities = 44/151 (29%), Positives = 70/151 (46%), Gaps = 3/151 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
LL A +AG+ V++L + Q+ + T LH AA V + L+ +GA V A
Sbjct: 496 LLEAAKAGDVETVKKLCTVQSVN-CRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA 554
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G PLH A + G + + A +AD TP+H AA G I +LL +
Sbjct: 555 KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLL-Q 613
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMML 217
A ++ +DG+T + + +G D +L
Sbjct: 614 HGADPTKKNRDGNTPLDLVK-DGDTDIQDLL 643
Score = 55.2 bits (127), Expect = 2e-06
Identities = 38/119 (31%), Positives = 56/119 (47%), Gaps = 2/119 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL LA N + LL Q + A G LH AA VD+A +L+ Y
Sbjct: 678 RHSTPLHLAAGYNNLEVAEYLL--QHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYN 735
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A V+AT+ TPLH AA +G L A+ + + E +TP+ L + + +A++
Sbjct: 736 ACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794
Score = 54.8 bits (126), Expect = 3e-06
Identities = 42/131 (32%), Positives = 59/131 (45%), Gaps = 3/131 (2%)
Query: 92 KATTPAGDTALHLAARRRDVDMARILVDYGAVVDA-TNGAGQTPLHIAAAEGDEPLVKYF 150
+A PA L A R DV+ + LV V T G TPLH AA G + +V+Y
Sbjct: 19 EAVEPAA-RELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYL 77
Query: 151 YGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
AN D+ P+H A GHA ++ LL + A R T +H A++ G
Sbjct: 78 LQNGANVQARDDGGLIPLHNACSFGHAEVVNLLL-RHGADPNARDNWNYTPLHEAAIKGK 136
Query: 211 ADCAMMLFKKG 221
D ++L + G
Sbjct: 137 IDVCIVLLQHG 147
Score = 44.8 bits (101), Expect = 0.003
Identities = 37/98 (37%), Positives = 46/98 (46%), Gaps = 4/98 (4%)
Query: 662 DGARS--IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYG 719
DG +S +H AA Y V I+ LLQ G V + LH A V E L+ +G
Sbjct: 208 DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 267
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
A V+ Q TPLH AA + C+L LL GA P
Sbjct: 268 ACVNAMDLWQ-FTPLHEAASKNRVEVCSL-LLSYGADP 303
Score = 44.4 bits (100), Expect = 0.004
Identities = 43/170 (25%), Positives = 69/170 (40%), Gaps = 6/170 (3%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL A G + +V LL Q ++A G LH A ++ +L+ +G
Sbjct: 57 RKSTPLHFAAGFGRKDVVEYLL--QNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHG 114
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE 181
A +A + TPLH AA +G + A I + + RT + LA + A
Sbjct: 115 ADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAV--- 171
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNG-HADCAMMLFKKGVYLHMPNKY 230
L + K + E + G+ +A L + +C +K LH+ Y
Sbjct: 172 LTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGY 221
Score = 42.3 bits (95), Expect = 0.018
Identities = 32/123 (26%), Positives = 47/123 (38%), Gaps = 1/123 (0%)
Query: 99 DTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAA 158
D L A + M +L A++G TPLH+AA +V+ A+
Sbjct: 179 DELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVH 238
Query: 159 IADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF 218
D D P+H A GH + ELL K A + T +H A+ + +L
Sbjct: 239 AKDKGDLVPLHNACSYGHYEVTELLV-KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 297
Query: 219 KKG 221
G
Sbjct: 298 SYG 300
Score = 39.1 bits (87), Expect = 0.17
Identities = 30/117 (25%), Positives = 51/117 (43%), Gaps = 4/117 (3%)
Query: 71 VEAGNQSMVRELLSAQTAEQLKATTP-AGDTALHLAARR---RDVDMARILVDYGAVVDA 126
++A ++ V + + E + P +TALH AA + + +L+ GA ++
Sbjct: 336 LQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINE 395
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
TPLH+A+ + +V+ A DN +T +H AA GH LL
Sbjct: 396 KTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452
Score = 35.5 bits (78), Expect = 2.1
Identities = 21/75 (28%), Positives = 35/75 (46%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T LH+A+ + D+ ++V + A V+A + GQT LH AA G + + I
Sbjct: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
Query: 160 ADNEDRTPMHLAAEN 174
+ T + + EN
Sbjct: 462 ISLQGFTALQMGNEN 476
Score = 33.5 bits (73), Expect = 8.3
Identities = 38/159 (23%), Positives = 66/159 (41%), Gaps = 10/159 (6%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL LA +V+ LL Q + A LH A ++ +LV +G
Sbjct: 210 RKSTPLHLAAGYNRVKIVQLLL--QHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 267
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE 181
A V+A + TPLH AA++ + A+ + + +++ + LA + E
Sbjct: 268 ACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPT---PQLKE 324
Query: 182 LLADKFKA-SIFERTKDGSTLMHIASLNGHADCAMMLFK 219
LA +FK S+ + ++ + + H M+ FK
Sbjct: 325 RLAYEFKGHSLLQAAREAD----VTRIKKHLSLEMVNFK 359
>AF438201-1|AAL40795.1| 1166|Homo sapiens tankyrase II protein.
Length = 1166
Score = 170 bits (413), Expect = 5e-41
Identities = 199/761 (26%), Positives = 321/761 (42%), Gaps = 60/761 (7%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA +G ++ LLQ G +V + LH A VV LL +GAD + R
Sbjct: 62 LHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARD 121
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
TPLH AA D C ++LL+ GA P DG T + +A A VL E
Sbjct: 122 N-WNYTPLHEAAIKGKIDVC-IVLLQHGAEPTIRNTDGRTALDLADPS---AKAVLTGEY 176
Query: 787 GGDPLRKTKVCIYD--VVTGETPLQMAC-----RSCMPDIVRHLIEFVKDHKGESVSTAF 839
D L ++ + ++ TPL + C R P + VK + A
Sbjct: 177 KKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGAD 236
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+ A D+ LH AC EV + L+++GA V+ T H A
Sbjct: 237 VHAKDKGDLVPLHNACSYGHYEV---------TELLVKHGACVNAMDLWQF-TPLHEAAS 286
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQN-SIGWTPLL---IACH-RGHMQLVN------TL 948
+V + ++++ + + N+ + TP L +A +GH L T
Sbjct: 287 KNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTR 346
Query: 949 LTNHARVDVFDVEG----RSALHLAAEHGY---LQVCDALLTNKAFINSKARNGRTALHL 1001
+ H +++ + + +ALH AA Y Q+C+ LL A IN K + T LH+
Sbjct: 347 IKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHV 406
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A+ + +V+ +++ H A ++ L QT LH AA G ++ C+LLL G + +
Sbjct: 407 ASEKAHNDVVEVVVK-HEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQ 465
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
G + +N VQ LQ+ +L + + AA G V+ +++L
Sbjct: 466 GFTALQMGNEN-----VQQLLQEGISL---GNSEADRQLLEAAKAGDVETVKKLCTVQSV 517
Query: 1122 GVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVL 1181
+ STPL AA VV L++ GA +++ GL +H A +GH V
Sbjct: 518 NCRDIEGR--QSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVA 575
Query: 1182 DVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGA 1241
+++ + + TPLH AA G+ E + LL H K L V
Sbjct: 576 ELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDG 635
Query: 1242 ESGLTPLHL-------AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSI 1294
++ + L AA G V+ L + V + PLHLA ++ +
Sbjct: 636 DTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHS-TPLHLAAGYNNLEV 694
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
LL A++ ++ D+ G LH A+++GH + +L+ A +NATDK +TPLH AA
Sbjct: 695 AEYLLQHGADV-NAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAA 753
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVL 1395
+ G + LL GA P + P+ ++++ + +L
Sbjct: 754 QKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794
Score = 150 bits (363), Expect = 6e-35
Identities = 163/618 (26%), Positives = 259/618 (41%), Gaps = 79/618 (12%)
Query: 806 TPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIP 865
TPL A D+V +L++ + A + A D+ G LH AC EV
Sbjct: 60 TPLHFAAGFGRKDVVEYLLQ----------NGANVQARDDGGLIPLHNACSFGHAEV--- 106
Query: 866 TADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAH------------- 912
V L+ +GAD + + N+ T H AI G DV ++ H
Sbjct: 107 ------VNLLLRHGADPNARDNWNY-TPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRT 159
Query: 913 -ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSA--LHLA 969
+ AD S LL + G+ + + LLT V+ +GR + LHLA
Sbjct: 160 ALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLA 218
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKK 1029
A + +++ LL + A +++K + LH A G+ + + L++ H A ++ + L +
Sbjct: 219 AGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK-HGACVNAMDLWQ 277
Query: 1030 QTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
TPLH AA+ ++EVC LLL GA+ + + I A E + + H L
Sbjct: 278 FTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQ 337
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA---D 1146
A D + + K +++ ++ T L AA +
Sbjct: 338 AAREAD----------------VTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQ 381
Query: 1147 VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
+ +L+R GA+ ++ + LT +H+A+E H +V++V+ + LG T LH AA
Sbjct: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS 1266
Y G +T R LLS+ P +SL G T L + GNENV +LL
Sbjct: 442 YCGHLQTCRLLLSY------GCDPNIISL-------QGFTALQM----GNENVQQLL--Q 482
Query: 1267 AGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHY 1326
G+ + N L A G + V L + + + T LH A+ +
Sbjct: 483 EGI---SLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRV 539
Query: 1327 QMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFA 1386
+VE LL GA+++A DK G PLH A GH V +LL + GA P+ A
Sbjct: 540 SVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEA 599
Query: 1387 ASENHNDVLEYLLHKEHD 1404
A++ ++ + LL D
Sbjct: 600 AAKGKYEICKLLLQHGAD 617
Score = 146 bits (354), Expect = 7e-34
Identities = 199/746 (26%), Positives = 322/746 (43%), Gaps = 112/746 (15%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H A +GH ++N LL+ G + N NYT LH A K V LL +GA+
Sbjct: 91 GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 150
Query: 723 HIRG-------------------GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATED 763
IR G+ ++ L +AR G++ +M L + N D
Sbjct: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESAR--SGNEEKMMALLTPLNVNCHASD 208
Query: 764 G--MTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVR 821
G TP+H+AA + + + LLL+ G D K K D+V PL AC ++
Sbjct: 209 GRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDK---GDLV----PLHNACSYGHYEVTE 261
Query: 822 HLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEV----KIPTADRQVVKCLIE 877
L++ A ++A+D + LH A + EV AD ++ C +
Sbjct: 262 LLVK----------HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNK 311
Query: 878 NGADVS----LQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPL 933
+ D++ L+ R +E H A +T + H+S V+ + +
Sbjct: 312 SAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCA 371
Query: 934 LIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKAR 993
+ + Q+ LL A ++ E + LH+A+E + V + ++ ++A +N+
Sbjct: 372 AASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDN 431
Query: 994 NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHL------------------ 1035
G+T+LH AA G+ + L+ + ++++L+ T L +
Sbjct: 432 LGQTSLHRAAYCGHLQTCRLLL-SYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNS 490
Query: 1036 --------AAASGQIEVCKLLLELGANIDATDELGQK--PIHAAAQNNYSEVVQLFLQQH 1085
AA +G +E K L + +++ D G++ P+H AA N VV+ +L QH
Sbjct: 491 EADRQLLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVE-YLLQH 548
Query: 1086 PNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA 1145
V A K G H A G +V E L+K G + L TPL AA G
Sbjct: 549 GADVHAKDKGGLVPLHNACSYGHYEVAELLVKH---GAVVNVADLWKFTPLHEAAAKGKY 605
Query: 1146 DVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIA 1205
++ ++L++ GA T +NR G T + L + G T++ D++R L ++KK
Sbjct: 606 EICKLLLQHGADPTKKNRDGNTPLDLVKD-GDTDIQDLLRGDAALLDAAKK--------- 655
Query: 1206 AYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA-YNGNENVVRLLL 1264
G V++L S P V+ G S TPLHLAA YN E LL
Sbjct: 656 ---GCLARVKKLSS----------PDNVNCRDTQGRHS--TPLHLAAGYNNLEVAEYLLQ 700
Query: 1265 NSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHG 1324
+ A V A ++ G PLH A GH+ + LL+ +A +++TD+ T LH A+ G
Sbjct: 701 HGADVN---AQDKGGLIPLHNAASYGHVDVAALLIKYNA-CVNATDKWAFTPLHEAAQKG 756
Query: 1325 HYQMVEVLLGQGAEINATDKNGWTPL 1350
Q+ +LL GA+ ++ G TPL
Sbjct: 757 RTQLCALLLAHGADPTLKNQEGQTPL 782
Score = 137 bits (332), Expect = 3e-31
Identities = 185/739 (25%), Positives = 304/739 (41%), Gaps = 98/739 (13%)
Query: 729 QRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGG 788
++ TPLH AA D LL++GA + G+ P+H A FG+ + LLL G
Sbjct: 57 RKSTPLHFAAGFGRKDVVEY-LLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGA 115
Query: 789 DPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESV-STAFIDAVDEDG 847
DP + TPL A D+ L++ + + +D D
Sbjct: 116 DPNARDN-------WNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSA 168
Query: 848 ASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMT 907
+ L K + + + + + L+ +V+ ++ + A AG N V
Sbjct: 169 KAVLTGEYKKDELLESARSGNEEKMMALL-TPLNVNCHASDGRKSTPLHLA-AGYNRVKI 226
Query: 908 EMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALH 967
+ ADV A ++ + + PL AC GH ++ L+ + A V+ D+ + LH
Sbjct: 227 VQLLLQHGADV-HAKDKGDLV---PLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLH 282
Query: 968 LAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM-----I 1022
AA ++VC LL+ A + ++A+ LA + + + H+ +
Sbjct: 283 EAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREA 342
Query: 1023 DVLTLKK---------------QTPLHLAAAS---GQIEVCKLLLELGANIDATDELGQK 1064
DV +KK +T LH AAAS + ++C+LLL GANI+ +
Sbjct: 343 DVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLT 402
Query: 1065 PIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFD-RTGV 1123
P+H A++ +++VV++ + +H V A G T H AA G ++ L+ + +
Sbjct: 403 PLHVASEKAHNDVVEVVV-KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
Query: 1124 ISARN----KLNDSTPLQLAAEG---GHADVVRVLVRA----------------GASCTD 1160
IS + ++ + QL EG G+++ R L+ A +C D
Sbjct: 462 ISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRD 521
Query: 1161 ENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSH 1220
T +H AA + +V++ + + K GL PLH A YG E L+ H
Sbjct: 522 IEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKH 581
Query: 1221 VPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGY 1280
G V + A TPLH AA G + +LLL N +G
Sbjct: 582 --GAVVNVADLW-----------KFTPLHEAAAKGKYEICKLLLQHGA--DPTKKNRDGN 626
Query: 1281 NPLHLACFG---------GHMSIVGL----LLSR-----SAELLHSTDRHGK--TGLHIA 1320
PL L G G +++ L+R S + ++ D G+ T LH+A
Sbjct: 627 TPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLA 686
Query: 1321 STHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNC 1380
+ + + ++ E LL GA++NA DK G PLH AA GH++V LL + A +
Sbjct: 687 AGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAF 746
Query: 1381 APIWFAASENHNDVLEYLL 1399
P+ AA + + LL
Sbjct: 747 TPLHEAAQKGRTQLCALLL 765
Score = 116 bits (278), Expect = 1e-24
Identities = 151/557 (27%), Positives = 228/557 (40%), Gaps = 71/557 (12%)
Query: 933 LLIACHRGHMQLVNTLLTNHARVDVFDVEGRSA--LHLAAEHGYLQVCDALLTNKAFINS 990
L AC G ++ V L+T +V+ D GR + LH AA G V + LL N A + +
Sbjct: 28 LFEACRNGDVERVKRLVTPE-KVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQA 86
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
+ G LH A G+A +V L+R H A + TPLH AA G+I+VC +LL+
Sbjct: 87 RDDGGLIPLHNACSFGHAEVVNLLLR-HGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 145
Query: 1051 LGAN--IDATD-----ELGQKPIHAAAQNNYS--EVVQLFLQQHPNLVMAT--------- 1092
GA I TD +L A Y E+++ + +MA
Sbjct: 146 HGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCH 205
Query: 1093 TKDG--NTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRV 1150
DG +T H+AA VK+++ L++ + A++K D PL A GH +V +
Sbjct: 206 ASDGRKSTPLHLAAGYNRVKIVQLLLQHGAD--VHAKDK-GDLVPLHNACSYGHYEVTEL 262
Query: 1151 LVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRS-------TNTLRISSKKLGLTPL- 1202
LV+ GA + T +H AA V ++ S N S+ L TP
Sbjct: 263 LVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQL 322
Query: 1203 -HIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA---YNGNEN 1258
AY + ++ + T + + + +V ++ T LH AA Y +
Sbjct: 323 KERLAYEFKGHSLLQAAREADVT-RIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQ 381
Query: 1259 VVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH 1318
+ LLL G + + E PLH+A H +V +++ A++ ++ D G+T LH
Sbjct: 382 ICELLLRK-GANINEKTKEF-LTPLHVASEKAHNDVVEVVVKHEAKV-NALDNLGQTSLH 438
Query: 1319 IASTHGHYQMVEVLLGQGAEINATDKNGWTPLHC-------------------------- 1352
A+ GH Q +LL G + N G+T L
Sbjct: 439 RAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLE 498
Query: 1353 AAKAGHLNVVKLLCE-SGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDD 1411
AAKAG + VK LC + + P+ FAA N V+EYLL D + D
Sbjct: 499 AAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA-KDK 557
Query: 1412 KRFVYNLMVCSKNHNNI 1428
V CS H +
Sbjct: 558 GGLVPLHNACSYGHYEV 574
Score = 74.5 bits (175), Expect = 4e-12
Identities = 95/382 (24%), Positives = 153/382 (40%), Gaps = 33/382 (8%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G S+H AA GH+ LL G ++ + +TAL + E+ V+ LL G +
Sbjct: 433 GQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGISL 487
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
G + + L AA+ D + + TP+H AA + ++ +
Sbjct: 488 ---GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 544
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFI-- 840
LL+ G D K K G PL AC ++ L++ G V+ A +
Sbjct: 545 LLQHGADVHAKDK-------GGLVPLHNACSYGHYEVAELLVKH-----GAVVNVADLWK 592
Query: 841 -DAVDEDGASALHYACKVTKEEVKIPTA---DRQVVKCLIENGADVSLQTRHNHETAFHY 896
+ E A + CK+ + PT D L+++G D +Q + A
Sbjct: 593 FTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDG-DTDIQDLLRGDAALLD 651
Query: 897 CAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVD 956
A G + +S+ D + Q TPL +A ++++ LL + A V+
Sbjct: 652 AAKKG----CLARVKKLSSPDNVNCRDTQGRHS-TPLHLAAGYNNLEVAEYLLQHGADVN 706
Query: 957 VFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIR 1016
D G LH AA +G++ V L+ A +N+ + T LH AA G L L+
Sbjct: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLA 766
Query: 1017 DHNAMIDVLTLKKQTPLHLAAA 1038
H A + + QTPL L +A
Sbjct: 767 -HGADPTLKNQEGQTPLDLVSA 787
Score = 70.9 bits (166), Expect = 4e-11
Identities = 50/136 (36%), Positives = 64/136 (47%), Gaps = 4/136 (2%)
Query: 1266 SAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGK--TGLHIASTH 1323
+A A A + E L AC G + V L++ E ++S D G+ T LH A+
Sbjct: 11 AACASAAAEAVEPAARELFEACRNGDVERVKRLVT--PEKVNSRDTAGRKSTPLHFAAGF 68
Query: 1324 GHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPI 1383
G +VE LL GA + A D G PLH A GH VV LL GA P + N N P+
Sbjct: 69 GRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPL 128
Query: 1384 WFAASENHNDVLEYLL 1399
AA + DV LL
Sbjct: 129 HEAAIKGKIDVCIVLL 144
Score = 58.0 bits (134), Expect = 3e-07
Identities = 42/129 (32%), Positives = 62/129 (48%), Gaps = 3/129 (2%)
Query: 55 IRDLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMA 114
I+DL+ RG LL A + G + V++L S + T T LHLAA ++++A
Sbjct: 639 IQDLL--RGDAALLDAAKKGCLARVKKLSSPDNVN-CRDTQGRHSTPLHLAAGYNNLEVA 695
Query: 115 RILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAEN 174
L+ +GA V+A + G PLH AA+ G + A D TP+H AA+
Sbjct: 696 EYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQK 755
Query: 175 GHAAIIELL 183
G + LL
Sbjct: 756 GRTQLCALL 764
Score = 55.2 bits (127), Expect = 2e-06
Identities = 44/151 (29%), Positives = 70/151 (46%), Gaps = 3/151 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
LL A +AG+ V++L + Q+ + T LH AA V + L+ +GA V A
Sbjct: 496 LLEAAKAGDVETVKKLCTVQSVN-CRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA 554
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G PLH A + G + + A +AD TP+H AA G I +LL +
Sbjct: 555 KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLL-Q 613
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMML 217
A ++ +DG+T + + +G D +L
Sbjct: 614 HGADPTKKNRDGNTPLDLVK-DGDTDIQDLL 643
Score = 55.2 bits (127), Expect = 2e-06
Identities = 38/119 (31%), Positives = 56/119 (47%), Gaps = 2/119 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL LA N + LL Q + A G LH AA VD+A +L+ Y
Sbjct: 678 RHSTPLHLAAGYNNLEVAEYLL--QHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYN 735
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A V+AT+ TPLH AA +G L A+ + + E +TP+ L + + +A++
Sbjct: 736 ACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794
Score = 54.8 bits (126), Expect = 3e-06
Identities = 42/131 (32%), Positives = 59/131 (45%), Gaps = 3/131 (2%)
Query: 92 KATTPAGDTALHLAARRRDVDMARILVDYGAVVDA-TNGAGQTPLHIAAAEGDEPLVKYF 150
+A PA L A R DV+ + LV V T G TPLH AA G + +V+Y
Sbjct: 19 EAVEPAA-RELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYL 77
Query: 151 YGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
AN D+ P+H A GHA ++ LL + A R T +H A++ G
Sbjct: 78 LQNGANVQARDDGGLIPLHNACSFGHAEVVNLLL-RHGADPNARDNWNYTPLHEAAIKGK 136
Query: 211 ADCAMMLFKKG 221
D ++L + G
Sbjct: 137 IDVCIVLLQHG 147
Score = 44.8 bits (101), Expect = 0.003
Identities = 37/98 (37%), Positives = 46/98 (46%), Gaps = 4/98 (4%)
Query: 662 DGARS--IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYG 719
DG +S +H AA Y V I+ LLQ G V + LH A V E L+ +G
Sbjct: 208 DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 267
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
A V+ Q TPLH AA + C+L LL GA P
Sbjct: 268 ACVNAMDLWQ-FTPLHEAASKNRVEVCSL-LLSYGADP 303
Score = 44.4 bits (100), Expect = 0.004
Identities = 43/170 (25%), Positives = 69/170 (40%), Gaps = 6/170 (3%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL A G + +V LL Q ++A G LH A ++ +L+ +G
Sbjct: 57 RKSTPLHFAAGFGRKDVVEYLL--QNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHG 114
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE 181
A +A + TPLH AA +G + A I + + RT + LA + A
Sbjct: 115 ADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAV--- 171
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNG-HADCAMMLFKKGVYLHMPNKY 230
L + K + E + G+ +A L + +C +K LH+ Y
Sbjct: 172 LTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGY 221
Score = 42.3 bits (95), Expect = 0.018
Identities = 32/123 (26%), Positives = 47/123 (38%), Gaps = 1/123 (0%)
Query: 99 DTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAA 158
D L A + M +L A++G TPLH+AA +V+ A+
Sbjct: 179 DELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVH 238
Query: 159 IADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF 218
D D P+H A GH + ELL K A + T +H A+ + +L
Sbjct: 239 AKDKGDLVPLHNACSYGHYEVTELLV-KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 297
Query: 219 KKG 221
G
Sbjct: 298 SYG 300
Score = 39.1 bits (87), Expect = 0.17
Identities = 30/117 (25%), Positives = 51/117 (43%), Gaps = 4/117 (3%)
Query: 71 VEAGNQSMVRELLSAQTAEQLKATTP-AGDTALHLAARR---RDVDMARILVDYGAVVDA 126
++A ++ V + + E + P +TALH AA + + +L+ GA ++
Sbjct: 336 LQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINE 395
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
TPLH+A+ + +V+ A DN +T +H AA GH LL
Sbjct: 396 KTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452
Score = 35.5 bits (78), Expect = 2.1
Identities = 21/75 (28%), Positives = 35/75 (46%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T LH+A+ + D+ ++V + A V+A + GQT LH AA G + + I
Sbjct: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
Query: 160 ADNEDRTPMHLAAEN 174
+ T + + EN
Sbjct: 462 ISLQGFTALQMGNEN 476
Score = 33.5 bits (73), Expect = 8.3
Identities = 38/159 (23%), Positives = 66/159 (41%), Gaps = 10/159 (6%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL LA +V+ LL Q + A LH A ++ +LV +G
Sbjct: 210 RKSTPLHLAAGYNRVKIVQLLL--QHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 267
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE 181
A V+A + TPLH AA++ + A+ + + +++ + LA + E
Sbjct: 268 ACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPT---PQLKE 324
Query: 182 LLADKFKA-SIFERTKDGSTLMHIASLNGHADCAMMLFK 219
LA +FK S+ + ++ + + H M+ FK
Sbjct: 325 RLAYEFKGHSLLQAAREAD----VTRIKKHLSLEMVNFK 359
>AF342982-1|AAK25811.1| 1166|Homo sapiens tankyrase 2 protein.
Length = 1166
Score = 170 bits (413), Expect = 5e-41
Identities = 199/761 (26%), Positives = 321/761 (42%), Gaps = 60/761 (7%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA +G ++ LLQ G +V + LH A VV LL +GAD + R
Sbjct: 62 LHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARD 121
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
TPLH AA D C ++LL+ GA P DG T + +A A VL E
Sbjct: 122 N-WNYTPLHEAAIKGKIDVC-IVLLQHGAEPTIRNTDGRTALDLADPS---AKAVLTGEY 176
Query: 787 GGDPLRKTKVCIYD--VVTGETPLQMAC-----RSCMPDIVRHLIEFVKDHKGESVSTAF 839
D L ++ + ++ TPL + C R P + VK + A
Sbjct: 177 KKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGAD 236
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+ A D+ LH AC EV + L+++GA V+ T H A
Sbjct: 237 VHAKDKGDLVPLHNACSYGHYEV---------TELLVKHGACVNAMDLWQF-TPLHEAAS 286
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQN-SIGWTPLL---IACH-RGHMQLVN------TL 948
+V + ++++ + + N+ + TP L +A +GH L T
Sbjct: 287 KNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTR 346
Query: 949 LTNHARVDVFDVEG----RSALHLAAEHGY---LQVCDALLTNKAFINSKARNGRTALHL 1001
+ H +++ + + +ALH AA Y Q+C+ LL A IN K + T LH+
Sbjct: 347 IKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHV 406
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A+ + +V+ +++ H A ++ L QT LH AA G ++ C+LLL G + +
Sbjct: 407 ASEKAHNDVVEVVVK-HEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQ 465
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
G + +N VQ LQ+ +L + + AA G V+ +++L
Sbjct: 466 GFTALQMGNEN-----VQQLLQEGISL---GNSEADRQLLEAAKAGDVETVKKLCTVQSV 517
Query: 1122 GVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVL 1181
+ STPL AA VV L++ GA +++ GL +H A +GH V
Sbjct: 518 NCRDIEGR--QSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVA 575
Query: 1182 DVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGA 1241
+++ + + TPLH AA G+ E + LL H K L V
Sbjct: 576 ELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDG 635
Query: 1242 ESGLTPLHL-------AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSI 1294
++ + L AA G V+ L + V + PLHLA ++ +
Sbjct: 636 DTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHS-TPLHLAAGYNNLEV 694
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
LL A++ ++ D+ G LH A+++GH + +L+ A +NATDK +TPLH AA
Sbjct: 695 AEYLLQHGADV-NAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAA 753
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVL 1395
+ G + LL GA P + P+ ++++ + +L
Sbjct: 754 QKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794
Score = 150 bits (363), Expect = 6e-35
Identities = 163/618 (26%), Positives = 259/618 (41%), Gaps = 79/618 (12%)
Query: 806 TPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIP 865
TPL A D+V +L++ + A + A D+ G LH AC EV
Sbjct: 60 TPLHFAAGFGRKDVVEYLLQ----------NGANVQARDDGGLIPLHNACSFGHAEV--- 106
Query: 866 TADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAH------------- 912
V L+ +GAD + + N+ T H AI G DV ++ H
Sbjct: 107 ------VNLLLRHGADPNARDNWNY-TPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRT 159
Query: 913 -ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSA--LHLA 969
+ AD S LL + G+ + + LLT V+ +GR + LHLA
Sbjct: 160 ALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLA 218
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKK 1029
A + +++ LL + A +++K + LH A G+ + + L++ H A ++ + L +
Sbjct: 219 AGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK-HGACVNAMDLWQ 277
Query: 1030 QTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
TPLH AA+ ++EVC LLL GA+ + + I A E + + H L
Sbjct: 278 FTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQ 337
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA---D 1146
A D + + K +++ ++ T L AA +
Sbjct: 338 AAREAD----------------VTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQ 381
Query: 1147 VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
+ +L+R GA+ ++ + LT +H+A+E H +V++V+ + LG T LH AA
Sbjct: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS 1266
Y G +T R LLS+ P +SL G T L + GNENV +LL
Sbjct: 442 YCGHLQTCRLLLSY------GCDPNIISL-------QGFTALQM----GNENVQQLL--Q 482
Query: 1267 AGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHY 1326
G+ + N L A G + V L + + + T LH A+ +
Sbjct: 483 EGI---SLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRV 539
Query: 1327 QMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFA 1386
+VE LL GA+++A DK G PLH A GH V +LL + GA P+ A
Sbjct: 540 SVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEA 599
Query: 1387 ASENHNDVLEYLLHKEHD 1404
A++ ++ + LL D
Sbjct: 600 AAKGKYEICKLLLQHGAD 617
Score = 146 bits (354), Expect = 7e-34
Identities = 199/746 (26%), Positives = 322/746 (43%), Gaps = 112/746 (15%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H A +GH ++N LL+ G + N NYT LH A K V LL +GA+
Sbjct: 91 GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 150
Query: 723 HIRG-------------------GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATED 763
IR G+ ++ L +AR G++ +M L + N D
Sbjct: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESAR--SGNEEKMMALLTPLNVNCHASD 208
Query: 764 G--MTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVR 821
G TP+H+AA + + + LLL+ G D K K D+V PL AC ++
Sbjct: 209 GRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDK---GDLV----PLHNACSYGHYEVTE 261
Query: 822 HLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEV----KIPTADRQVVKCLIE 877
L++ A ++A+D + LH A + EV AD ++ C +
Sbjct: 262 LLVK----------HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNK 311
Query: 878 NGADVS----LQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPL 933
+ D++ L+ R +E H A +T + H+S V+ + +
Sbjct: 312 SAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCA 371
Query: 934 LIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKAR 993
+ + Q+ LL A ++ E + LH+A+E + V + ++ ++A +N+
Sbjct: 372 AASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDN 431
Query: 994 NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHL------------------ 1035
G+T+LH AA G+ + L+ + ++++L+ T L +
Sbjct: 432 LGQTSLHRAAYCGHLQTCRLLL-SYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNS 490
Query: 1036 --------AAASGQIEVCKLLLELGANIDATDELGQK--PIHAAAQNNYSEVVQLFLQQH 1085
AA +G +E K L + +++ D G++ P+H AA N VV+ +L QH
Sbjct: 491 EADRQLLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVE-YLLQH 548
Query: 1086 PNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA 1145
V A K G H A G +V E L+K G + L TPL AA G
Sbjct: 549 GADVHAKDKGGLVPLHNACSYGHYEVAELLVKH---GAVVNVADLWKFTPLHEAAAKGKY 605
Query: 1146 DVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIA 1205
++ ++L++ GA T +NR G T + L + G T++ D++R L ++KK
Sbjct: 606 EICKLLLQHGADPTKKNRDGNTPLDLVKD-GDTDIQDLLRGDAALLDAAKK--------- 655
Query: 1206 AYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA-YNGNENVVRLLL 1264
G V++L S P V+ G S TPLHLAA YN E LL
Sbjct: 656 ---GCLARVKKLSS----------PDNVNCRDTQGRHS--TPLHLAAGYNNLEVAEYLLQ 700
Query: 1265 NSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHG 1324
+ A V A ++ G PLH A GH+ + LL+ +A +++TD+ T LH A+ G
Sbjct: 701 HGADVN---AQDKGGLIPLHNAASYGHVDVAALLIKYNA-CVNATDKWAFTPLHEAAQKG 756
Query: 1325 HYQMVEVLLGQGAEINATDKNGWTPL 1350
Q+ +LL GA+ ++ G TPL
Sbjct: 757 RTQLCALLLAHGADPTLKNQEGQTPL 782
Score = 137 bits (332), Expect = 3e-31
Identities = 185/739 (25%), Positives = 304/739 (41%), Gaps = 98/739 (13%)
Query: 729 QRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGG 788
++ TPLH AA D LL++GA + G+ P+H A FG+ + LLL G
Sbjct: 57 RKSTPLHFAAGFGRKDVVEY-LLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGA 115
Query: 789 DPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESV-STAFIDAVDEDG 847
DP + TPL A D+ L++ + + +D D
Sbjct: 116 DPNARDN-------WNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSA 168
Query: 848 ASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMT 907
+ L K + + + + + L+ +V+ ++ + A AG N V
Sbjct: 169 KAVLTGEYKKDELLESARSGNEEKMMALL-TPLNVNCHASDGRKSTPLHLA-AGYNRVKI 226
Query: 908 EMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALH 967
+ ADV A ++ + + PL AC GH ++ L+ + A V+ D+ + LH
Sbjct: 227 VQLLLQHGADV-HAKDKGDLV---PLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLH 282
Query: 968 LAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM-----I 1022
AA ++VC LL+ A + ++A+ LA + + + H+ +
Sbjct: 283 EAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREA 342
Query: 1023 DVLTLKK---------------QTPLHLAAAS---GQIEVCKLLLELGANIDATDELGQK 1064
DV +KK +T LH AAAS + ++C+LLL GANI+ +
Sbjct: 343 DVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLT 402
Query: 1065 PIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFD-RTGV 1123
P+H A++ +++VV++ + +H V A G T H AA G ++ L+ + +
Sbjct: 403 PLHVASEKAHNDVVEVVV-KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
Query: 1124 ISARN----KLNDSTPLQLAAEG---GHADVVRVLVRA----------------GASCTD 1160
IS + ++ + QL EG G+++ R L+ A +C D
Sbjct: 462 ISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRD 521
Query: 1161 ENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSH 1220
T +H AA + +V++ + + K GL PLH A YG E L+ H
Sbjct: 522 IEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKH 581
Query: 1221 VPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGY 1280
G V + A TPLH AA G + +LLL N +G
Sbjct: 582 --GAVVNVADLW-----------KFTPLHEAAAKGKYEICKLLLQHGA--DPTKKNRDGN 626
Query: 1281 NPLHLACFG---------GHMSIVGL----LLSR-----SAELLHSTDRHGK--TGLHIA 1320
PL L G G +++ L+R S + ++ D G+ T LH+A
Sbjct: 627 TPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLA 686
Query: 1321 STHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNC 1380
+ + + ++ E LL GA++NA DK G PLH AA GH++V LL + A +
Sbjct: 687 AGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAF 746
Query: 1381 APIWFAASENHNDVLEYLL 1399
P+ AA + + LL
Sbjct: 747 TPLHEAAQKGRTQLCALLL 765
Score = 116 bits (278), Expect = 1e-24
Identities = 151/557 (27%), Positives = 228/557 (40%), Gaps = 71/557 (12%)
Query: 933 LLIACHRGHMQLVNTLLTNHARVDVFDVEGRSA--LHLAAEHGYLQVCDALLTNKAFINS 990
L AC G ++ V L+T +V+ D GR + LH AA G V + LL N A + +
Sbjct: 28 LFEACRNGDVERVKRLVTPE-KVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQA 86
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
+ G LH A G+A +V L+R H A + TPLH AA G+I+VC +LL+
Sbjct: 87 RDDGGLIPLHNACSFGHAEVVNLLLR-HGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 145
Query: 1051 LGAN--IDATD-----ELGQKPIHAAAQNNYS--EVVQLFLQQHPNLVMAT--------- 1092
GA I TD +L A Y E+++ + +MA
Sbjct: 146 HGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCH 205
Query: 1093 TKDG--NTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRV 1150
DG +T H+AA VK+++ L++ + A++K D PL A GH +V +
Sbjct: 206 ASDGRKSTPLHLAAGYNRVKIVQLLLQHGAD--VHAKDK-GDLVPLHNACSYGHYEVTEL 262
Query: 1151 LVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRS-------TNTLRISSKKLGLTPL- 1202
LV+ GA + T +H AA V ++ S N S+ L TP
Sbjct: 263 LVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQL 322
Query: 1203 -HIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA---YNGNEN 1258
AY + ++ + T + + + +V ++ T LH AA Y +
Sbjct: 323 KERLAYEFKGHSLLQAAREADVT-RIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQ 381
Query: 1259 VVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH 1318
+ LLL G + + E PLH+A H +V +++ A++ ++ D G+T LH
Sbjct: 382 ICELLLRK-GANINEKTKEF-LTPLHVASEKAHNDVVEVVVKHEAKV-NALDNLGQTSLH 438
Query: 1319 IASTHGHYQMVEVLLGQGAEINATDKNGWTPLHC-------------------------- 1352
A+ GH Q +LL G + N G+T L
Sbjct: 439 RAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLE 498
Query: 1353 AAKAGHLNVVKLLCE-SGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDD 1411
AAKAG + VK LC + + P+ FAA N V+EYLL D + D
Sbjct: 499 AAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA-KDK 557
Query: 1412 KRFVYNLMVCSKNHNNI 1428
V CS H +
Sbjct: 558 GGLVPLHNACSYGHYEV 574
Score = 74.5 bits (175), Expect = 4e-12
Identities = 95/382 (24%), Positives = 153/382 (40%), Gaps = 33/382 (8%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G S+H AA GH+ LL G ++ + +TAL + E+ V+ LL G +
Sbjct: 433 GQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGISL 487
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
G + + L AA+ D + + TP+H AA + ++ +
Sbjct: 488 ---GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 544
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFI-- 840
LL+ G D K K G PL AC ++ L++ G V+ A +
Sbjct: 545 LLQHGADVHAKDK-------GGLVPLHNACSYGHYEVAELLVKH-----GAVVNVADLWK 592
Query: 841 -DAVDEDGASALHYACKVTKEEVKIPTA---DRQVVKCLIENGADVSLQTRHNHETAFHY 896
+ E A + CK+ + PT D L+++G D +Q + A
Sbjct: 593 FTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDG-DTDIQDLLRGDAALLD 651
Query: 897 CAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVD 956
A G + +S+ D + Q TPL +A ++++ LL + A V+
Sbjct: 652 AAKKG----CLARVKKLSSPDNVNCRDTQGRHS-TPLHLAAGYNNLEVAEYLLQHGADVN 706
Query: 957 VFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIR 1016
D G LH AA +G++ V L+ A +N+ + T LH AA G L L+
Sbjct: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLA 766
Query: 1017 DHNAMIDVLTLKKQTPLHLAAA 1038
H A + + QTPL L +A
Sbjct: 767 -HGADPTLKNQEGQTPLDLVSA 787
Score = 70.9 bits (166), Expect = 4e-11
Identities = 50/136 (36%), Positives = 64/136 (47%), Gaps = 4/136 (2%)
Query: 1266 SAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGK--TGLHIASTH 1323
+A A A + E L AC G + V L++ E ++S D G+ T LH A+
Sbjct: 11 AACASAAAEAVEPAARELFEACRNGDVERVKRLVT--PEKVNSRDTAGRKSTPLHFAAGF 68
Query: 1324 GHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPI 1383
G +VE LL GA + A D G PLH A GH VV LL GA P + N N P+
Sbjct: 69 GRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPL 128
Query: 1384 WFAASENHNDVLEYLL 1399
AA + DV LL
Sbjct: 129 HEAAIKGKIDVCIVLL 144
Score = 58.0 bits (134), Expect = 3e-07
Identities = 42/129 (32%), Positives = 62/129 (48%), Gaps = 3/129 (2%)
Query: 55 IRDLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMA 114
I+DL+ RG LL A + G + V++L S + T T LHLAA ++++A
Sbjct: 639 IQDLL--RGDAALLDAAKKGCLARVKKLSSPDNVN-CRDTQGRHSTPLHLAAGYNNLEVA 695
Query: 115 RILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAEN 174
L+ +GA V+A + G PLH AA+ G + A D TP+H AA+
Sbjct: 696 EYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQK 755
Query: 175 GHAAIIELL 183
G + LL
Sbjct: 756 GRTQLCALL 764
Score = 55.2 bits (127), Expect = 2e-06
Identities = 44/151 (29%), Positives = 70/151 (46%), Gaps = 3/151 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
LL A +AG+ V++L + Q+ + T LH AA V + L+ +GA V A
Sbjct: 496 LLEAAKAGDVETVKKLCTVQSVN-CRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA 554
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G PLH A + G + + A +AD TP+H AA G I +LL +
Sbjct: 555 KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLL-Q 613
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMML 217
A ++ +DG+T + + +G D +L
Sbjct: 614 HGADPTKKNRDGNTPLDLVK-DGDTDIQDLL 643
Score = 55.2 bits (127), Expect = 2e-06
Identities = 38/119 (31%), Positives = 56/119 (47%), Gaps = 2/119 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL LA N + LL Q + A G LH AA VD+A +L+ Y
Sbjct: 678 RHSTPLHLAAGYNNLEVAEYLL--QHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYN 735
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A V+AT+ TPLH AA +G L A+ + + E +TP+ L + + +A++
Sbjct: 736 ACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794
Score = 54.8 bits (126), Expect = 3e-06
Identities = 42/131 (32%), Positives = 59/131 (45%), Gaps = 3/131 (2%)
Query: 92 KATTPAGDTALHLAARRRDVDMARILVDYGAVVDA-TNGAGQTPLHIAAAEGDEPLVKYF 150
+A PA L A R DV+ + LV V T G TPLH AA G + +V+Y
Sbjct: 19 EAVEPAA-RELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYL 77
Query: 151 YGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
AN D+ P+H A GHA ++ LL + A R T +H A++ G
Sbjct: 78 LQNGANVQARDDGGLIPLHNACSFGHAEVVNLLL-RHGADPNARDNWNYTPLHEAAIKGK 136
Query: 211 ADCAMMLFKKG 221
D ++L + G
Sbjct: 137 IDVCIVLLQHG 147
Score = 44.8 bits (101), Expect = 0.003
Identities = 37/98 (37%), Positives = 46/98 (46%), Gaps = 4/98 (4%)
Query: 662 DGARS--IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYG 719
DG +S +H AA Y V I+ LLQ G V + LH A V E L+ +G
Sbjct: 208 DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 267
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
A V+ Q TPLH AA + C+L LL GA P
Sbjct: 268 ACVNAMDLWQ-FTPLHEAASKNRVEVCSL-LLSYGADP 303
Score = 44.4 bits (100), Expect = 0.004
Identities = 43/170 (25%), Positives = 69/170 (40%), Gaps = 6/170 (3%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL A G + +V LL Q ++A G LH A ++ +L+ +G
Sbjct: 57 RKSTPLHFAAGFGRKDVVEYLL--QNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHG 114
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE 181
A +A + TPLH AA +G + A I + + RT + LA + A
Sbjct: 115 ADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAV--- 171
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNG-HADCAMMLFKKGVYLHMPNKY 230
L + K + E + G+ +A L + +C +K LH+ Y
Sbjct: 172 LTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGY 221
Score = 42.3 bits (95), Expect = 0.018
Identities = 32/123 (26%), Positives = 47/123 (38%), Gaps = 1/123 (0%)
Query: 99 DTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAA 158
D L A + M +L A++G TPLH+AA +V+ A+
Sbjct: 179 DELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVH 238
Query: 159 IADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF 218
D D P+H A GH + ELL K A + T +H A+ + +L
Sbjct: 239 AKDKGDLVPLHNACSYGHYEVTELLV-KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 297
Query: 219 KKG 221
G
Sbjct: 298 SYG 300
Score = 39.1 bits (87), Expect = 0.17
Identities = 30/117 (25%), Positives = 51/117 (43%), Gaps = 4/117 (3%)
Query: 71 VEAGNQSMVRELLSAQTAEQLKATTP-AGDTALHLAARR---RDVDMARILVDYGAVVDA 126
++A ++ V + + E + P +TALH AA + + +L+ GA ++
Sbjct: 336 LQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINE 395
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
TPLH+A+ + +V+ A DN +T +H AA GH LL
Sbjct: 396 KTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452
Score = 35.5 bits (78), Expect = 2.1
Identities = 21/75 (28%), Positives = 35/75 (46%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T LH+A+ + D+ ++V + A V+A + GQT LH AA G + + I
Sbjct: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
Query: 160 ADNEDRTPMHLAAEN 174
+ T + + EN
Sbjct: 462 ISLQGFTALQMGNEN 476
Score = 33.5 bits (73), Expect = 8.3
Identities = 38/159 (23%), Positives = 66/159 (41%), Gaps = 10/159 (6%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL LA +V+ LL Q + A LH A ++ +LV +G
Sbjct: 210 RKSTPLHLAAGYNRVKIVQLLL--QHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 267
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE 181
A V+A + TPLH AA++ + A+ + + +++ + LA + E
Sbjct: 268 ACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPT---PQLKE 324
Query: 182 LLADKFKA-SIFERTKDGSTLMHIASLNGHADCAMMLFK 219
LA +FK S+ + ++ + + H M+ FK
Sbjct: 325 RLAYEFKGHSLLQAAREAD----VTRIKKHLSLEMVNFK 359
>AF329696-1|AAK13463.1| 1166|Homo sapiens tankyrase 2 protein.
Length = 1166
Score = 170 bits (413), Expect = 5e-41
Identities = 199/761 (26%), Positives = 321/761 (42%), Gaps = 60/761 (7%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA +G ++ LLQ G +V + LH A VV LL +GAD + R
Sbjct: 62 LHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARD 121
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
TPLH AA D C ++LL+ GA P DG T + +A A VL E
Sbjct: 122 N-WNYTPLHEAAIKGKIDVC-IVLLQHGAEPTIRNTDGRTALDLADPS---AKAVLTGEY 176
Query: 787 GGDPLRKTKVCIYD--VVTGETPLQMAC-----RSCMPDIVRHLIEFVKDHKGESVSTAF 839
D L ++ + ++ TPL + C R P + VK + A
Sbjct: 177 KKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGAD 236
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+ A D+ LH AC EV + L+++GA V+ T H A
Sbjct: 237 VHAKDKGDLVPLHNACSYGHYEV---------TELLVKHGACVNAMDLWQF-TPLHEAAS 286
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQN-SIGWTPLL---IACH-RGHMQLVN------TL 948
+V + ++++ + + N+ + TP L +A +GH L T
Sbjct: 287 KNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTR 346
Query: 949 LTNHARVDVFDVEG----RSALHLAAEHGY---LQVCDALLTNKAFINSKARNGRTALHL 1001
+ H +++ + + +ALH AA Y Q+C+ LL A IN K + T LH+
Sbjct: 347 IKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHV 406
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A+ + +V+ +++ H A ++ L QT LH AA G ++ C+LLL G + +
Sbjct: 407 ASEKAHNDVVEVVVK-HEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQ 465
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
G + +N VQ LQ+ +L + + AA G V+ +++L
Sbjct: 466 GFTALQMGNEN-----VQQLLQEGISL---GNSEADRQLLEAAKAGDVETVKKLCTVQSV 517
Query: 1122 GVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVL 1181
+ STPL AA VV L++ GA +++ GL +H A +GH V
Sbjct: 518 NCRDIEGR--QSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVA 575
Query: 1182 DVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGA 1241
+++ + + TPLH AA G+ E + LL H K L V
Sbjct: 576 ELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDG 635
Query: 1242 ESGLTPLHL-------AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSI 1294
++ + L AA G V+ L + V + PLHLA ++ +
Sbjct: 636 DTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHS-TPLHLAAGYNNLEV 694
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
LL A++ ++ D+ G LH A+++GH + +L+ A +NATDK +TPLH AA
Sbjct: 695 AEYLLQHGADV-NAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAA 753
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVL 1395
+ G + LL GA P + P+ ++++ + +L
Sbjct: 754 QKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794
Score = 150 bits (363), Expect = 6e-35
Identities = 163/618 (26%), Positives = 259/618 (41%), Gaps = 79/618 (12%)
Query: 806 TPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIP 865
TPL A D+V +L++ + A + A D+ G LH AC EV
Sbjct: 60 TPLHFAAGFGRKDVVEYLLQ----------NGANVQARDDGGLIPLHNACSFGHAEV--- 106
Query: 866 TADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAH------------- 912
V L+ +GAD + + N+ T H AI G DV ++ H
Sbjct: 107 ------VNLLLRHGADPNARDNWNY-TPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRT 159
Query: 913 -ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSA--LHLA 969
+ AD S LL + G+ + + LLT V+ +GR + LHLA
Sbjct: 160 ALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLA 218
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKK 1029
A + +++ LL + A +++K + LH A G+ + + L++ H A ++ + L +
Sbjct: 219 AGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK-HGACVNAMDLWQ 277
Query: 1030 QTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
TPLH AA+ ++EVC LLL GA+ + + I A E + + H L
Sbjct: 278 FTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQ 337
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA---D 1146
A D + + K +++ ++ T L AA +
Sbjct: 338 AAREAD----------------VTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQ 381
Query: 1147 VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
+ +L+R GA+ ++ + LT +H+A+E H +V++V+ + LG T LH AA
Sbjct: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS 1266
Y G +T R LLS+ P +SL G T L + GNENV +LL
Sbjct: 442 YCGHLQTCRLLLSY------GCDPNIISL-------QGFTALQM----GNENVQQLL--Q 482
Query: 1267 AGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHY 1326
G+ + N L A G + V L + + + T LH A+ +
Sbjct: 483 EGI---SLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRV 539
Query: 1327 QMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFA 1386
+VE LL GA+++A DK G PLH A GH V +LL + GA P+ A
Sbjct: 540 SVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEA 599
Query: 1387 ASENHNDVLEYLLHKEHD 1404
A++ ++ + LL D
Sbjct: 600 AAKGKYEICKLLLQHGAD 617
Score = 146 bits (354), Expect = 7e-34
Identities = 199/746 (26%), Positives = 322/746 (43%), Gaps = 112/746 (15%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H A +GH ++N LL+ G + N NYT LH A K V LL +GA+
Sbjct: 91 GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 150
Query: 723 HIRG-------------------GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATED 763
IR G+ ++ L +AR G++ +M L + N D
Sbjct: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESAR--SGNEEKMMALLTPLNVNCHASD 208
Query: 764 G--MTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVR 821
G TP+H+AA + + + LLL+ G D K K D+V PL AC ++
Sbjct: 209 GRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDK---GDLV----PLHNACSYGHYEVTE 261
Query: 822 HLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEV----KIPTADRQVVKCLIE 877
L++ A ++A+D + LH A + EV AD ++ C +
Sbjct: 262 LLVK----------HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNK 311
Query: 878 NGADVS----LQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPL 933
+ D++ L+ R +E H A +T + H+S V+ + +
Sbjct: 312 SAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCA 371
Query: 934 LIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKAR 993
+ + Q+ LL A ++ E + LH+A+E + V + ++ ++A +N+
Sbjct: 372 AASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDN 431
Query: 994 NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHL------------------ 1035
G+T+LH AA G+ + L+ + ++++L+ T L +
Sbjct: 432 LGQTSLHRAAYCGHLQTCRLLL-SYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNS 490
Query: 1036 --------AAASGQIEVCKLLLELGANIDATDELGQK--PIHAAAQNNYSEVVQLFLQQH 1085
AA +G +E K L + +++ D G++ P+H AA N VV+ +L QH
Sbjct: 491 EADRQLLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVE-YLLQH 548
Query: 1086 PNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA 1145
V A K G H A G +V E L+K G + L TPL AA G
Sbjct: 549 GADVHAKDKGGLVPLHNACSYGHYEVAELLVKH---GAVVNVADLWKFTPLHEAAAKGKY 605
Query: 1146 DVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIA 1205
++ ++L++ GA T +NR G T + L + G T++ D++R L ++KK
Sbjct: 606 EICKLLLQHGADPTKKNRDGNTPLDLVKD-GDTDIQDLLRGDAALLDAAKK--------- 655
Query: 1206 AYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA-YNGNENVVRLLL 1264
G V++L S P V+ G S TPLHLAA YN E LL
Sbjct: 656 ---GCLARVKKLSS----------PDNVNCRDTQGRHS--TPLHLAAGYNNLEVAEYLLQ 700
Query: 1265 NSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHG 1324
+ A V A ++ G PLH A GH+ + LL+ +A +++TD+ T LH A+ G
Sbjct: 701 HGADVN---AQDKGGLIPLHNAASYGHVDVAALLIKYNA-CVNATDKWAFTPLHEAAQKG 756
Query: 1325 HYQMVEVLLGQGAEINATDKNGWTPL 1350
Q+ +LL GA+ ++ G TPL
Sbjct: 757 RTQLCALLLAHGADPTLKNQEGQTPL 782
Score = 137 bits (332), Expect = 3e-31
Identities = 185/739 (25%), Positives = 304/739 (41%), Gaps = 98/739 (13%)
Query: 729 QRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGG 788
++ TPLH AA D LL++GA + G+ P+H A FG+ + LLL G
Sbjct: 57 RKSTPLHFAAGFGRKDVVEY-LLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGA 115
Query: 789 DPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESV-STAFIDAVDEDG 847
DP + TPL A D+ L++ + + +D D
Sbjct: 116 DPNARDN-------WNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSA 168
Query: 848 ASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMT 907
+ L K + + + + + L+ +V+ ++ + A AG N V
Sbjct: 169 KAVLTGEYKKDELLESARSGNEEKMMALL-TPLNVNCHASDGRKSTPLHLA-AGYNRVKI 226
Query: 908 EMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALH 967
+ ADV A ++ + + PL AC GH ++ L+ + A V+ D+ + LH
Sbjct: 227 VQLLLQHGADV-HAKDKGDLV---PLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLH 282
Query: 968 LAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM-----I 1022
AA ++VC LL+ A + ++A+ LA + + + H+ +
Sbjct: 283 EAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREA 342
Query: 1023 DVLTLKK---------------QTPLHLAAAS---GQIEVCKLLLELGANIDATDELGQK 1064
DV +KK +T LH AAAS + ++C+LLL GANI+ +
Sbjct: 343 DVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLT 402
Query: 1065 PIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFD-RTGV 1123
P+H A++ +++VV++ + +H V A G T H AA G ++ L+ + +
Sbjct: 403 PLHVASEKAHNDVVEVVV-KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
Query: 1124 ISARN----KLNDSTPLQLAAEG---GHADVVRVLVRA----------------GASCTD 1160
IS + ++ + QL EG G+++ R L+ A +C D
Sbjct: 462 ISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRD 521
Query: 1161 ENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSH 1220
T +H AA + +V++ + + K GL PLH A YG E L+ H
Sbjct: 522 IEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKH 581
Query: 1221 VPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGY 1280
G V + A TPLH AA G + +LLL N +G
Sbjct: 582 --GAVVNVADLW-----------KFTPLHEAAAKGKYEICKLLLQHGA--DPTKKNRDGN 626
Query: 1281 NPLHLACFG---------GHMSIVGL----LLSR-----SAELLHSTDRHGK--TGLHIA 1320
PL L G G +++ L+R S + ++ D G+ T LH+A
Sbjct: 627 TPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLA 686
Query: 1321 STHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNC 1380
+ + + ++ E LL GA++NA DK G PLH AA GH++V LL + A +
Sbjct: 687 AGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAF 746
Query: 1381 APIWFAASENHNDVLEYLL 1399
P+ AA + + LL
Sbjct: 747 TPLHEAAQKGRTQLCALLL 765
Score = 116 bits (278), Expect = 1e-24
Identities = 151/557 (27%), Positives = 228/557 (40%), Gaps = 71/557 (12%)
Query: 933 LLIACHRGHMQLVNTLLTNHARVDVFDVEGRSA--LHLAAEHGYLQVCDALLTNKAFINS 990
L AC G ++ V L+T +V+ D GR + LH AA G V + LL N A + +
Sbjct: 28 LFEACRNGDVERVKRLVTPE-KVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQA 86
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
+ G LH A G+A +V L+R H A + TPLH AA G+I+VC +LL+
Sbjct: 87 RDDGGLIPLHNACSFGHAEVVNLLLR-HGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 145
Query: 1051 LGAN--IDATD-----ELGQKPIHAAAQNNYS--EVVQLFLQQHPNLVMAT--------- 1092
GA I TD +L A Y E+++ + +MA
Sbjct: 146 HGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCH 205
Query: 1093 TKDG--NTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRV 1150
DG +T H+AA VK+++ L++ + A++K D PL A GH +V +
Sbjct: 206 ASDGRKSTPLHLAAGYNRVKIVQLLLQHGAD--VHAKDK-GDLVPLHNACSYGHYEVTEL 262
Query: 1151 LVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRS-------TNTLRISSKKLGLTPL- 1202
LV+ GA + T +H AA V ++ S N S+ L TP
Sbjct: 263 LVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQL 322
Query: 1203 -HIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA---YNGNEN 1258
AY + ++ + T + + + +V ++ T LH AA Y +
Sbjct: 323 KERLAYEFKGHSLLQAAREADVT-RIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQ 381
Query: 1259 VVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH 1318
+ LLL G + + E PLH+A H +V +++ A++ ++ D G+T LH
Sbjct: 382 ICELLLRK-GANINEKTKEF-LTPLHVASEKAHNDVVEVVVKHEAKV-NALDNLGQTSLH 438
Query: 1319 IASTHGHYQMVEVLLGQGAEINATDKNGWTPLHC-------------------------- 1352
A+ GH Q +LL G + N G+T L
Sbjct: 439 RAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLE 498
Query: 1353 AAKAGHLNVVKLLCE-SGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDD 1411
AAKAG + VK LC + + P+ FAA N V+EYLL D + D
Sbjct: 499 AAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA-KDK 557
Query: 1412 KRFVYNLMVCSKNHNNI 1428
V CS H +
Sbjct: 558 GGLVPLHNACSYGHYEV 574
Score = 74.5 bits (175), Expect = 4e-12
Identities = 95/382 (24%), Positives = 153/382 (40%), Gaps = 33/382 (8%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G S+H AA GH+ LL G ++ + +TAL + E+ V+ LL G +
Sbjct: 433 GQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGISL 487
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
G + + L AA+ D + + TP+H AA + ++ +
Sbjct: 488 ---GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 544
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFI-- 840
LL+ G D K K G PL AC ++ L++ G V+ A +
Sbjct: 545 LLQHGADVHAKDK-------GGLVPLHNACSYGHYEVAELLVKH-----GAVVNVADLWK 592
Query: 841 -DAVDEDGASALHYACKVTKEEVKIPTA---DRQVVKCLIENGADVSLQTRHNHETAFHY 896
+ E A + CK+ + PT D L+++G D +Q + A
Sbjct: 593 FTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDG-DTDIQDLLRGDAALLD 651
Query: 897 CAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVD 956
A G + +S+ D + Q TPL +A ++++ LL + A V+
Sbjct: 652 AAKKG----CLARVKKLSSPDNVNCRDTQGRHS-TPLHLAAGYNNLEVAEYLLQHGADVN 706
Query: 957 VFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIR 1016
D G LH AA +G++ V L+ A +N+ + T LH AA G L L+
Sbjct: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLA 766
Query: 1017 DHNAMIDVLTLKKQTPLHLAAA 1038
H A + + QTPL L +A
Sbjct: 767 -HGADPTLKNQEGQTPLDLVSA 787
Score = 70.9 bits (166), Expect = 4e-11
Identities = 50/136 (36%), Positives = 64/136 (47%), Gaps = 4/136 (2%)
Query: 1266 SAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGK--TGLHIASTH 1323
+A A A + E L AC G + V L++ E ++S D G+ T LH A+
Sbjct: 11 AACASAAAEAVEPAARELFEACRNGDVERVKRLVT--PEKVNSRDTAGRKSTPLHFAAGF 68
Query: 1324 GHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPI 1383
G +VE LL GA + A D G PLH A GH VV LL GA P + N N P+
Sbjct: 69 GRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPL 128
Query: 1384 WFAASENHNDVLEYLL 1399
AA + DV LL
Sbjct: 129 HEAAIKGKIDVCIVLL 144
Score = 58.0 bits (134), Expect = 3e-07
Identities = 42/129 (32%), Positives = 62/129 (48%), Gaps = 3/129 (2%)
Query: 55 IRDLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMA 114
I+DL+ RG LL A + G + V++L S + T T LHLAA ++++A
Sbjct: 639 IQDLL--RGDAALLDAAKKGCLARVKKLSSPDNVN-CRDTQGRHSTPLHLAAGYNNLEVA 695
Query: 115 RILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAEN 174
L+ +GA V+A + G PLH AA+ G + A D TP+H AA+
Sbjct: 696 EYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQK 755
Query: 175 GHAAIIELL 183
G + LL
Sbjct: 756 GRTQLCALL 764
Score = 55.2 bits (127), Expect = 2e-06
Identities = 44/151 (29%), Positives = 70/151 (46%), Gaps = 3/151 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
LL A +AG+ V++L + Q+ + T LH AA V + L+ +GA V A
Sbjct: 496 LLEAAKAGDVETVKKLCTVQSVN-CRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA 554
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G PLH A + G + + A +AD TP+H AA G I +LL +
Sbjct: 555 KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLL-Q 613
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMML 217
A ++ +DG+T + + +G D +L
Sbjct: 614 HGADPTKKNRDGNTPLDLVK-DGDTDIQDLL 643
Score = 55.2 bits (127), Expect = 2e-06
Identities = 38/119 (31%), Positives = 56/119 (47%), Gaps = 2/119 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL LA N + LL Q + A G LH AA VD+A +L+ Y
Sbjct: 678 RHSTPLHLAAGYNNLEVAEYLL--QHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYN 735
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A V+AT+ TPLH AA +G L A+ + + E +TP+ L + + +A++
Sbjct: 736 ACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794
Score = 54.8 bits (126), Expect = 3e-06
Identities = 42/131 (32%), Positives = 59/131 (45%), Gaps = 3/131 (2%)
Query: 92 KATTPAGDTALHLAARRRDVDMARILVDYGAVVDA-TNGAGQTPLHIAAAEGDEPLVKYF 150
+A PA L A R DV+ + LV V T G TPLH AA G + +V+Y
Sbjct: 19 EAVEPAA-RELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYL 77
Query: 151 YGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
AN D+ P+H A GHA ++ LL + A R T +H A++ G
Sbjct: 78 LQNGANVQARDDGGLIPLHNACSFGHAEVVNLLL-RHGADPNARDNWNYTPLHEAAIKGK 136
Query: 211 ADCAMMLFKKG 221
D ++L + G
Sbjct: 137 IDVCIVLLQHG 147
Score = 44.8 bits (101), Expect = 0.003
Identities = 37/98 (37%), Positives = 46/98 (46%), Gaps = 4/98 (4%)
Query: 662 DGARS--IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYG 719
DG +S +H AA Y V I+ LLQ G V + LH A V E L+ +G
Sbjct: 208 DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 267
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
A V+ Q TPLH AA + C+L LL GA P
Sbjct: 268 ACVNAMDLWQ-FTPLHEAASKNRVEVCSL-LLSYGADP 303
Score = 44.4 bits (100), Expect = 0.004
Identities = 43/170 (25%), Positives = 69/170 (40%), Gaps = 6/170 (3%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL A G + +V LL Q ++A G LH A ++ +L+ +G
Sbjct: 57 RKSTPLHFAAGFGRKDVVEYLL--QNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHG 114
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE 181
A +A + TPLH AA +G + A I + + RT + LA + A
Sbjct: 115 ADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAV--- 171
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNG-HADCAMMLFKKGVYLHMPNKY 230
L + K + E + G+ +A L + +C +K LH+ Y
Sbjct: 172 LTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGY 221
Score = 42.3 bits (95), Expect = 0.018
Identities = 32/123 (26%), Positives = 47/123 (38%), Gaps = 1/123 (0%)
Query: 99 DTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAA 158
D L A + M +L A++G TPLH+AA +V+ A+
Sbjct: 179 DELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVH 238
Query: 159 IADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF 218
D D P+H A GH + ELL K A + T +H A+ + +L
Sbjct: 239 AKDKGDLVPLHNACSYGHYEVTELLV-KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 297
Query: 219 KKG 221
G
Sbjct: 298 SYG 300
Score = 39.1 bits (87), Expect = 0.17
Identities = 30/117 (25%), Positives = 51/117 (43%), Gaps = 4/117 (3%)
Query: 71 VEAGNQSMVRELLSAQTAEQLKATTP-AGDTALHLAARR---RDVDMARILVDYGAVVDA 126
++A ++ V + + E + P +TALH AA + + +L+ GA ++
Sbjct: 336 LQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINE 395
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
TPLH+A+ + +V+ A DN +T +H AA GH LL
Sbjct: 396 KTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452
Score = 35.5 bits (78), Expect = 2.1
Identities = 21/75 (28%), Positives = 35/75 (46%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T LH+A+ + D+ ++V + A V+A + GQT LH AA G + + I
Sbjct: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
Query: 160 ADNEDRTPMHLAAEN 174
+ T + + EN
Sbjct: 462 ISLQGFTALQMGNEN 476
Score = 33.5 bits (73), Expect = 8.3
Identities = 38/159 (23%), Positives = 66/159 (41%), Gaps = 10/159 (6%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL LA +V+ LL Q + A LH A ++ +LV +G
Sbjct: 210 RKSTPLHLAAGYNRVKIVQLLL--QHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 267
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE 181
A V+A + TPLH AA++ + A+ + + +++ + LA + E
Sbjct: 268 ACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPT---PQLKE 324
Query: 182 LLADKFKA-SIFERTKDGSTLMHIASLNGHADCAMMLFK 219
LA +FK S+ + ++ + + H M+ FK
Sbjct: 325 RLAYEFKGHSLLQAAREAD----VTRIKKHLSLEMVNFK 359
>AF309033-1|AAK82330.1| 1166|Homo sapiens tankyrase-2 protein.
Length = 1166
Score = 170 bits (413), Expect = 5e-41
Identities = 199/761 (26%), Positives = 321/761 (42%), Gaps = 60/761 (7%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA +G ++ LLQ G +V + LH A VV LL +GAD + R
Sbjct: 62 LHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARD 121
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
TPLH AA D C ++LL+ GA P DG T + +A A VL E
Sbjct: 122 N-WNYTPLHEAAIKGKIDVC-IVLLQHGAEPTIRNTDGRTALDLADPS---AKAVLTGEY 176
Query: 787 GGDPLRKTKVCIYD--VVTGETPLQMAC-----RSCMPDIVRHLIEFVKDHKGESVSTAF 839
D L ++ + ++ TPL + C R P + VK + A
Sbjct: 177 KKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGAD 236
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+ A D+ LH AC EV + L+++GA V+ T H A
Sbjct: 237 VHAKDKGDLVPLHNACSYGHYEV---------TELLVKHGACVNAMDLWQF-TPLHEAAS 286
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQN-SIGWTPLL---IACH-RGHMQLVN------TL 948
+V + ++++ + + N+ + TP L +A +GH L T
Sbjct: 287 KNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTR 346
Query: 949 LTNHARVDVFDVEG----RSALHLAAEHGY---LQVCDALLTNKAFINSKARNGRTALHL 1001
+ H +++ + + +ALH AA Y Q+C+ LL A IN K + T LH+
Sbjct: 347 IKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHV 406
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A+ + +V+ +++ H A ++ L QT LH AA G ++ C+LLL G + +
Sbjct: 407 ASEKAHNDVVEVVVK-HEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQ 465
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
G + +N VQ LQ+ +L + + AA G V+ +++L
Sbjct: 466 GFTALQMGNEN-----VQQLLQEGISL---GNSEADRQLLEAAKAGDVETVKKLCTVQSV 517
Query: 1122 GVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVL 1181
+ STPL AA VV L++ GA +++ GL +H A +GH V
Sbjct: 518 NCRDIEGR--QSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVA 575
Query: 1182 DVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGA 1241
+++ + + TPLH AA G+ E + LL H K L V
Sbjct: 576 ELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDG 635
Query: 1242 ESGLTPLHL-------AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSI 1294
++ + L AA G V+ L + V + PLHLA ++ +
Sbjct: 636 DTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHS-TPLHLAAGYNNLEV 694
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
LL A++ ++ D+ G LH A+++GH + +L+ A +NATDK +TPLH AA
Sbjct: 695 AEYLLQHGADV-NAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAA 753
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVL 1395
+ G + LL GA P + P+ ++++ + +L
Sbjct: 754 QKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794
Score = 150 bits (363), Expect = 6e-35
Identities = 163/618 (26%), Positives = 259/618 (41%), Gaps = 79/618 (12%)
Query: 806 TPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIP 865
TPL A D+V +L++ + A + A D+ G LH AC EV
Sbjct: 60 TPLHFAAGFGRKDVVEYLLQ----------NGANVQARDDGGLIPLHNACSFGHAEV--- 106
Query: 866 TADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAH------------- 912
V L+ +GAD + + N+ T H AI G DV ++ H
Sbjct: 107 ------VNLLLRHGADPNARDNWNY-TPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRT 159
Query: 913 -ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSA--LHLA 969
+ AD S LL + G+ + + LLT V+ +GR + LHLA
Sbjct: 160 ALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLA 218
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKK 1029
A + +++ LL + A +++K + LH A G+ + + L++ H A ++ + L +
Sbjct: 219 AGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK-HGACVNAMDLWQ 277
Query: 1030 QTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
TPLH AA+ ++EVC LLL GA+ + + I A E + + H L
Sbjct: 278 FTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQ 337
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA---D 1146
A D + + K +++ ++ T L AA +
Sbjct: 338 AAREAD----------------VTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQ 381
Query: 1147 VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
+ +L+R GA+ ++ + LT +H+A+E H +V++V+ + LG T LH AA
Sbjct: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS 1266
Y G +T R LLS+ P +SL G T L + GNENV +LL
Sbjct: 442 YCGHLQTCRLLLSY------GCDPNIISL-------QGFTALQM----GNENVQQLL--Q 482
Query: 1267 AGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHY 1326
G+ + N L A G + V L + + + T LH A+ +
Sbjct: 483 EGI---SLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRV 539
Query: 1327 QMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFA 1386
+VE LL GA+++A DK G PLH A GH V +LL + GA P+ A
Sbjct: 540 SVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEA 599
Query: 1387 ASENHNDVLEYLLHKEHD 1404
A++ ++ + LL D
Sbjct: 600 AAKGKYEICKLLLQHGAD 617
Score = 146 bits (354), Expect = 7e-34
Identities = 199/746 (26%), Positives = 322/746 (43%), Gaps = 112/746 (15%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H A +GH ++N LL+ G + N NYT LH A K V LL +GA+
Sbjct: 91 GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 150
Query: 723 HIRG-------------------GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATED 763
IR G+ ++ L +AR G++ +M L + N D
Sbjct: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESAR--SGNEEKMMALLTPLNVNCHASD 208
Query: 764 G--MTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVR 821
G TP+H+AA + + + LLL+ G D K K D+V PL AC ++
Sbjct: 209 GRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDK---GDLV----PLHNACSYGHYEVTE 261
Query: 822 HLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEV----KIPTADRQVVKCLIE 877
L++ A ++A+D + LH A + EV AD ++ C +
Sbjct: 262 LLVK----------HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNK 311
Query: 878 NGADVS----LQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPL 933
+ D++ L+ R +E H A +T + H+S V+ + +
Sbjct: 312 SAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCA 371
Query: 934 LIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKAR 993
+ + Q+ LL A ++ E + LH+A+E + V + ++ ++A +N+
Sbjct: 372 AASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDN 431
Query: 994 NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHL------------------ 1035
G+T+LH AA G+ + L+ + ++++L+ T L +
Sbjct: 432 LGQTSLHRAAYCGHLQTCRLLL-SYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNS 490
Query: 1036 --------AAASGQIEVCKLLLELGANIDATDELGQK--PIHAAAQNNYSEVVQLFLQQH 1085
AA +G +E K L + +++ D G++ P+H AA N VV+ +L QH
Sbjct: 491 EADRQLLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVE-YLLQH 548
Query: 1086 PNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA 1145
V A K G H A G +V E L+K G + L TPL AA G
Sbjct: 549 GADVHAKDKGGLVPLHNACSYGHYEVAELLVKH---GAVVNVADLWKFTPLHEAAAKGKY 605
Query: 1146 DVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIA 1205
++ ++L++ GA T +NR G T + L + G T++ D++R L ++KK
Sbjct: 606 EICKLLLQHGADPTKKNRDGNTPLDLVKD-GDTDIQDLLRGDAALLDAAKK--------- 655
Query: 1206 AYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA-YNGNENVVRLLL 1264
G V++L S P V+ G S TPLHLAA YN E LL
Sbjct: 656 ---GCLARVKKLSS----------PDNVNCRDTQGRHS--TPLHLAAGYNNLEVAEYLLQ 700
Query: 1265 NSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHG 1324
+ A V A ++ G PLH A GH+ + LL+ +A +++TD+ T LH A+ G
Sbjct: 701 HGADVN---AQDKGGLIPLHNAASYGHVDVAALLIKYNA-CVNATDKWAFTPLHEAAQKG 756
Query: 1325 HYQMVEVLLGQGAEINATDKNGWTPL 1350
Q+ +LL GA+ ++ G TPL
Sbjct: 757 RTQLCALLLAHGADPTLKNQEGQTPL 782
Score = 137 bits (332), Expect = 3e-31
Identities = 185/739 (25%), Positives = 304/739 (41%), Gaps = 98/739 (13%)
Query: 729 QRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGG 788
++ TPLH AA D LL++GA + G+ P+H A FG+ + LLL G
Sbjct: 57 RKSTPLHFAAGFGRKDVVEY-LLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGA 115
Query: 789 DPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESV-STAFIDAVDEDG 847
DP + TPL A D+ L++ + + +D D
Sbjct: 116 DPNARDN-------WNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSA 168
Query: 848 ASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMT 907
+ L K + + + + + L+ +V+ ++ + A AG N V
Sbjct: 169 KAVLTGEYKKDELLESARSGNEEKMMALL-TPLNVNCHASDGRKSTPLHLA-AGYNRVKI 226
Query: 908 EMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALH 967
+ ADV A ++ + + PL AC GH ++ L+ + A V+ D+ + LH
Sbjct: 227 VQLLLQHGADV-HAKDKGDLV---PLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLH 282
Query: 968 LAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM-----I 1022
AA ++VC LL+ A + ++A+ LA + + + H+ +
Sbjct: 283 EAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREA 342
Query: 1023 DVLTLKK---------------QTPLHLAAAS---GQIEVCKLLLELGANIDATDELGQK 1064
DV +KK +T LH AAAS + ++C+LLL GANI+ +
Sbjct: 343 DVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLT 402
Query: 1065 PIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFD-RTGV 1123
P+H A++ +++VV++ + +H V A G T H AA G ++ L+ + +
Sbjct: 403 PLHVASEKAHNDVVEVVV-KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
Query: 1124 ISARN----KLNDSTPLQLAAEG---GHADVVRVLVRA----------------GASCTD 1160
IS + ++ + QL EG G+++ R L+ A +C D
Sbjct: 462 ISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRD 521
Query: 1161 ENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSH 1220
T +H AA + +V++ + + K GL PLH A YG E L+ H
Sbjct: 522 IEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKH 581
Query: 1221 VPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGY 1280
G V + A TPLH AA G + +LLL N +G
Sbjct: 582 --GAVVNVADLW-----------KFTPLHEAAAKGKYEICKLLLQHGA--DPTKKNRDGN 626
Query: 1281 NPLHLACFG---------GHMSIVGL----LLSR-----SAELLHSTDRHGK--TGLHIA 1320
PL L G G +++ L+R S + ++ D G+ T LH+A
Sbjct: 627 TPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLA 686
Query: 1321 STHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNC 1380
+ + + ++ E LL GA++NA DK G PLH AA GH++V LL + A +
Sbjct: 687 AGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAF 746
Query: 1381 APIWFAASENHNDVLEYLL 1399
P+ AA + + LL
Sbjct: 747 TPLHEAAQKGRTQLCALLL 765
Score = 116 bits (278), Expect = 1e-24
Identities = 151/557 (27%), Positives = 228/557 (40%), Gaps = 71/557 (12%)
Query: 933 LLIACHRGHMQLVNTLLTNHARVDVFDVEGRSA--LHLAAEHGYLQVCDALLTNKAFINS 990
L AC G ++ V L+T +V+ D GR + LH AA G V + LL N A + +
Sbjct: 28 LFEACRNGDVERVKRLVTPE-KVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQA 86
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
+ G LH A G+A +V L+R H A + TPLH AA G+I+VC +LL+
Sbjct: 87 RDDGGLIPLHNACSFGHAEVVNLLLR-HGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 145
Query: 1051 LGAN--IDATD-----ELGQKPIHAAAQNNYS--EVVQLFLQQHPNLVMAT--------- 1092
GA I TD +L A Y E+++ + +MA
Sbjct: 146 HGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCH 205
Query: 1093 TKDG--NTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRV 1150
DG +T H+AA VK+++ L++ + A++K D PL A GH +V +
Sbjct: 206 ASDGRKSTPLHLAAGYNRVKIVQLLLQHGAD--VHAKDK-GDLVPLHNACSYGHYEVTEL 262
Query: 1151 LVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRS-------TNTLRISSKKLGLTPL- 1202
LV+ GA + T +H AA V ++ S N S+ L TP
Sbjct: 263 LVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQL 322
Query: 1203 -HIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA---YNGNEN 1258
AY + ++ + T + + + +V ++ T LH AA Y +
Sbjct: 323 KERLAYEFKGHSLLQAAREADVT-RIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQ 381
Query: 1259 VVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH 1318
+ LLL G + + E PLH+A H +V +++ A++ ++ D G+T LH
Sbjct: 382 ICELLLRK-GANINEKTKEF-LTPLHVASEKAHNDVVEVVVKHEAKV-NALDNLGQTSLH 438
Query: 1319 IASTHGHYQMVEVLLGQGAEINATDKNGWTPLHC-------------------------- 1352
A+ GH Q +LL G + N G+T L
Sbjct: 439 RAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLE 498
Query: 1353 AAKAGHLNVVKLLCE-SGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDD 1411
AAKAG + VK LC + + P+ FAA N V+EYLL D + D
Sbjct: 499 AAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA-KDK 557
Query: 1412 KRFVYNLMVCSKNHNNI 1428
V CS H +
Sbjct: 558 GGLVPLHNACSYGHYEV 574
Score = 74.5 bits (175), Expect = 4e-12
Identities = 95/382 (24%), Positives = 153/382 (40%), Gaps = 33/382 (8%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G S+H AA GH+ LL G ++ + +TAL + E+ V+ LL G +
Sbjct: 433 GQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGISL 487
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
G + + L AA+ D + + TP+H AA + ++ +
Sbjct: 488 ---GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 544
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFI-- 840
LL+ G D K K G PL AC ++ L++ G V+ A +
Sbjct: 545 LLQHGADVHAKDK-------GGLVPLHNACSYGHYEVAELLVKH-----GAVVNVADLWK 592
Query: 841 -DAVDEDGASALHYACKVTKEEVKIPTA---DRQVVKCLIENGADVSLQTRHNHETAFHY 896
+ E A + CK+ + PT D L+++G D +Q + A
Sbjct: 593 FTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDG-DTDIQDLLRGDAALLD 651
Query: 897 CAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVD 956
A G + +S+ D + Q TPL +A ++++ LL + A V+
Sbjct: 652 AAKKG----CLARVKKLSSPDNVNCRDTQGRHS-TPLHLAAGYNNLEVAEYLLQHGADVN 706
Query: 957 VFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIR 1016
D G LH AA +G++ V L+ A +N+ + T LH AA G L L+
Sbjct: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLA 766
Query: 1017 DHNAMIDVLTLKKQTPLHLAAA 1038
H A + + QTPL L +A
Sbjct: 767 -HGADPTLKNQEGQTPLDLVSA 787
Score = 70.9 bits (166), Expect = 4e-11
Identities = 50/136 (36%), Positives = 64/136 (47%), Gaps = 4/136 (2%)
Query: 1266 SAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGK--TGLHIASTH 1323
+A A A + E L AC G + V L++ E ++S D G+ T LH A+
Sbjct: 11 AACASAAAEAVEPAARELFEACRNGDVERVKRLVT--PEKVNSRDTAGRKSTPLHFAAGF 68
Query: 1324 GHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPI 1383
G +VE LL GA + A D G PLH A GH VV LL GA P + N N P+
Sbjct: 69 GRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPL 128
Query: 1384 WFAASENHNDVLEYLL 1399
AA + DV LL
Sbjct: 129 HEAAIKGKIDVCIVLL 144
Score = 58.0 bits (134), Expect = 3e-07
Identities = 42/129 (32%), Positives = 62/129 (48%), Gaps = 3/129 (2%)
Query: 55 IRDLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMA 114
I+DL+ RG LL A + G + V++L S + T T LHLAA ++++A
Sbjct: 639 IQDLL--RGDAALLDAAKKGCLARVKKLSSPDNVN-CRDTQGRHSTPLHLAAGYNNLEVA 695
Query: 115 RILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAEN 174
L+ +GA V+A + G PLH AA+ G + A D TP+H AA+
Sbjct: 696 EYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQK 755
Query: 175 GHAAIIELL 183
G + LL
Sbjct: 756 GRTQLCALL 764
Score = 55.2 bits (127), Expect = 2e-06
Identities = 44/151 (29%), Positives = 70/151 (46%), Gaps = 3/151 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
LL A +AG+ V++L + Q+ + T LH AA V + L+ +GA V A
Sbjct: 496 LLEAAKAGDVETVKKLCTVQSVN-CRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA 554
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G PLH A + G + + A +AD TP+H AA G I +LL +
Sbjct: 555 KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLL-Q 613
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMML 217
A ++ +DG+T + + +G D +L
Sbjct: 614 HGADPTKKNRDGNTPLDLVK-DGDTDIQDLL 643
Score = 55.2 bits (127), Expect = 2e-06
Identities = 38/119 (31%), Positives = 56/119 (47%), Gaps = 2/119 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL LA N + LL Q + A G LH AA VD+A +L+ Y
Sbjct: 678 RHSTPLHLAAGYNNLEVAEYLL--QHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYN 735
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A V+AT+ TPLH AA +G L A+ + + E +TP+ L + + +A++
Sbjct: 736 ACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794
Score = 54.8 bits (126), Expect = 3e-06
Identities = 42/131 (32%), Positives = 59/131 (45%), Gaps = 3/131 (2%)
Query: 92 KATTPAGDTALHLAARRRDVDMARILVDYGAVVDA-TNGAGQTPLHIAAAEGDEPLVKYF 150
+A PA L A R DV+ + LV V T G TPLH AA G + +V+Y
Sbjct: 19 EAVEPAA-RELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYL 77
Query: 151 YGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
AN D+ P+H A GHA ++ LL + A R T +H A++ G
Sbjct: 78 LQNGANVQARDDGGLIPLHNACSFGHAEVVNLLL-RHGADPNARDNWNYTPLHEAAIKGK 136
Query: 211 ADCAMMLFKKG 221
D ++L + G
Sbjct: 137 IDVCIVLLQHG 147
Score = 44.8 bits (101), Expect = 0.003
Identities = 37/98 (37%), Positives = 46/98 (46%), Gaps = 4/98 (4%)
Query: 662 DGARS--IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYG 719
DG +S +H AA Y V I+ LLQ G V + LH A V E L+ +G
Sbjct: 208 DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 267
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
A V+ Q TPLH AA + C+L LL GA P
Sbjct: 268 ACVNAMDLWQ-FTPLHEAASKNRVEVCSL-LLSYGADP 303
Score = 44.4 bits (100), Expect = 0.004
Identities = 43/170 (25%), Positives = 69/170 (40%), Gaps = 6/170 (3%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL A G + +V LL Q ++A G LH A ++ +L+ +G
Sbjct: 57 RKSTPLHFAAGFGRKDVVEYLL--QNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHG 114
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE 181
A +A + TPLH AA +G + A I + + RT + LA + A
Sbjct: 115 ADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAV--- 171
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNG-HADCAMMLFKKGVYLHMPNKY 230
L + K + E + G+ +A L + +C +K LH+ Y
Sbjct: 172 LTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGY 221
Score = 42.3 bits (95), Expect = 0.018
Identities = 32/123 (26%), Positives = 47/123 (38%), Gaps = 1/123 (0%)
Query: 99 DTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAA 158
D L A + M +L A++G TPLH+AA +V+ A+
Sbjct: 179 DELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVH 238
Query: 159 IADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF 218
D D P+H A GH + ELL K A + T +H A+ + +L
Sbjct: 239 AKDKGDLVPLHNACSYGHYEVTELLV-KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 297
Query: 219 KKG 221
G
Sbjct: 298 SYG 300
Score = 39.1 bits (87), Expect = 0.17
Identities = 30/117 (25%), Positives = 51/117 (43%), Gaps = 4/117 (3%)
Query: 71 VEAGNQSMVRELLSAQTAEQLKATTP-AGDTALHLAARR---RDVDMARILVDYGAVVDA 126
++A ++ V + + E + P +TALH AA + + +L+ GA ++
Sbjct: 336 LQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINE 395
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
TPLH+A+ + +V+ A DN +T +H AA GH LL
Sbjct: 396 KTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452
Score = 35.5 bits (78), Expect = 2.1
Identities = 21/75 (28%), Positives = 35/75 (46%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T LH+A+ + D+ ++V + A V+A + GQT LH AA G + + I
Sbjct: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
Query: 160 ADNEDRTPMHLAAEN 174
+ T + + EN
Sbjct: 462 ISLQGFTALQMGNEN 476
Score = 33.5 bits (73), Expect = 8.3
Identities = 38/159 (23%), Positives = 66/159 (41%), Gaps = 10/159 (6%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL LA +V+ LL Q + A LH A ++ +LV +G
Sbjct: 210 RKSTPLHLAAGYNRVKIVQLLL--QHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 267
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE 181
A V+A + TPLH AA++ + A+ + + +++ + LA + E
Sbjct: 268 ACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPT---PQLKE 324
Query: 182 LLADKFKA-SIFERTKDGSTLMHIASLNGHADCAMMLFK 219
LA +FK S+ + ++ + + H M+ FK
Sbjct: 325 RLAYEFKGHSLLQAAREAD----VTRIKKHLSLEMVNFK 359
>AF264912-1|AAG44694.1| 1166|Homo sapiens tankyrase-like protein
protein.
Length = 1166
Score = 170 bits (413), Expect = 5e-41
Identities = 199/761 (26%), Positives = 321/761 (42%), Gaps = 60/761 (7%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA +G ++ LLQ G +V + LH A VV LL +GAD + R
Sbjct: 62 LHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARD 121
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
TPLH AA D C ++LL+ GA P DG T + +A A VL E
Sbjct: 122 N-WNYTPLHEAAIKGKIDVC-IVLLQHGAEPTIRNTDGRTALDLADPS---AKAVLTGEY 176
Query: 787 GGDPLRKTKVCIYD--VVTGETPLQMAC-----RSCMPDIVRHLIEFVKDHKGESVSTAF 839
D L ++ + ++ TPL + C R P + VK + A
Sbjct: 177 KKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGAD 236
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+ A D+ LH AC EV + L+++GA V+ T H A
Sbjct: 237 VHAKDKGDLVPLHNACSYGHYEV---------TELLVKHGACVNAMDLWQF-TPLHEAAS 286
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQN-SIGWTPLL---IACH-RGHMQLVN------TL 948
+V + ++++ + + N+ + TP L +A +GH L T
Sbjct: 287 KNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTR 346
Query: 949 LTNHARVDVFDVEG----RSALHLAAEHGY---LQVCDALLTNKAFINSKARNGRTALHL 1001
+ H +++ + + +ALH AA Y Q+C+ LL A IN K + T LH+
Sbjct: 347 IKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHV 406
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A+ + +V+ +++ H A ++ L QT LH AA G ++ C+LLL G + +
Sbjct: 407 ASEKAHNDVVEVVVK-HEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQ 465
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
G + +N VQ LQ+ +L + + AA G V+ +++L
Sbjct: 466 GFTALQMGNEN-----VQQLLQEGISL---GNSEADRQLLEAAKAGDVETVKKLCTVQSV 517
Query: 1122 GVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVL 1181
+ STPL AA VV L++ GA +++ GL +H A +GH V
Sbjct: 518 NCRDIEGR--QSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVA 575
Query: 1182 DVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGA 1241
+++ + + TPLH AA G+ E + LL H K L V
Sbjct: 576 ELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDG 635
Query: 1242 ESGLTPLHL-------AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSI 1294
++ + L AA G V+ L + V + PLHLA ++ +
Sbjct: 636 DTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHS-TPLHLAAGYNNLEV 694
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
LL A++ ++ D+ G LH A+++GH + +L+ A +NATDK +TPLH AA
Sbjct: 695 AEYLLQHGADV-NAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAA 753
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVL 1395
+ G + LL GA P + P+ ++++ + +L
Sbjct: 754 QKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794
Score = 150 bits (363), Expect = 6e-35
Identities = 163/618 (26%), Positives = 259/618 (41%), Gaps = 79/618 (12%)
Query: 806 TPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIP 865
TPL A D+V +L++ + A + A D+ G LH AC EV
Sbjct: 60 TPLHFAAGFGRKDVVEYLLQ----------NGANVQARDDGGLIPLHNACSFGHAEV--- 106
Query: 866 TADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAH------------- 912
V L+ +GAD + + N+ T H AI G DV ++ H
Sbjct: 107 ------VNLLLRHGADPNARDNWNY-TPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRT 159
Query: 913 -ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSA--LHLA 969
+ AD S LL + G+ + + LLT V+ +GR + LHLA
Sbjct: 160 ALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLA 218
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKK 1029
A + +++ LL + A +++K + LH A G+ + + L++ H A ++ + L +
Sbjct: 219 AGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK-HGACVNAMDLWQ 277
Query: 1030 QTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
TPLH AA+ ++EVC LLL GA+ + + I A E + + H L
Sbjct: 278 FTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQ 337
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA---D 1146
A D + + K +++ ++ T L AA +
Sbjct: 338 AAREAD----------------VTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQ 381
Query: 1147 VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
+ +L+R GA+ ++ + LT +H+A+E H +V++V+ + LG T LH AA
Sbjct: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS 1266
Y G +T R LLS+ P +SL G T L + GNENV +LL
Sbjct: 442 YCGHLQTCRLLLSY------GCDPNIISL-------QGFTALQM----GNENVQQLL--Q 482
Query: 1267 AGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHY 1326
G+ + N L A G + V L + + + T LH A+ +
Sbjct: 483 EGI---SLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRV 539
Query: 1327 QMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFA 1386
+VE LL GA+++A DK G PLH A GH V +LL + GA P+ A
Sbjct: 540 SVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEA 599
Query: 1387 ASENHNDVLEYLLHKEHD 1404
A++ ++ + LL D
Sbjct: 600 AAKGKYEICKLLLQHGAD 617
Score = 146 bits (354), Expect = 7e-34
Identities = 199/746 (26%), Positives = 322/746 (43%), Gaps = 112/746 (15%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H A +GH ++N LL+ G + N NYT LH A K V LL +GA+
Sbjct: 91 GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 150
Query: 723 HIRG-------------------GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATED 763
IR G+ ++ L +AR G++ +M L + N D
Sbjct: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESAR--SGNEEKMMALLTPLNVNCHASD 208
Query: 764 G--MTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVR 821
G TP+H+AA + + + LLL+ G D K K D+V PL AC ++
Sbjct: 209 GRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDK---GDLV----PLHNACSYGHYEVTE 261
Query: 822 HLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEV----KIPTADRQVVKCLIE 877
L++ A ++A+D + LH A + EV AD ++ C +
Sbjct: 262 LLVK----------HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNK 311
Query: 878 NGADVS----LQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPL 933
+ D++ L+ R +E H A +T + H+S V+ + +
Sbjct: 312 SAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCA 371
Query: 934 LIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKAR 993
+ + Q+ LL A ++ E + LH+A+E + V + ++ ++A +N+
Sbjct: 372 AASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDN 431
Query: 994 NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHL------------------ 1035
G+T+LH AA G+ + L+ + ++++L+ T L +
Sbjct: 432 LGQTSLHRAAYCGHLQTCRLLL-SYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNS 490
Query: 1036 --------AAASGQIEVCKLLLELGANIDATDELGQK--PIHAAAQNNYSEVVQLFLQQH 1085
AA +G +E K L + +++ D G++ P+H AA N VV+ +L QH
Sbjct: 491 EADRQLLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVE-YLLQH 548
Query: 1086 PNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA 1145
V A K G H A G +V E L+K G + L TPL AA G
Sbjct: 549 GADVHAKDKGGLVPLHNACSYGHYEVAELLVKH---GAVVNVADLWKFTPLHEAAAKGKY 605
Query: 1146 DVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIA 1205
++ ++L++ GA T +NR G T + L + G T++ D++R L ++KK
Sbjct: 606 EICKLLLQHGADPTKKNRDGNTPLDLVKD-GDTDIQDLLRGDAALLDAAKK--------- 655
Query: 1206 AYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA-YNGNENVVRLLL 1264
G V++L S P V+ G S TPLHLAA YN E LL
Sbjct: 656 ---GCLARVKKLSS----------PDNVNCRDTQGRHS--TPLHLAAGYNNLEVAEYLLQ 700
Query: 1265 NSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHG 1324
+ A V A ++ G PLH A GH+ + LL+ +A +++TD+ T LH A+ G
Sbjct: 701 HGADVN---AQDKGGLIPLHNAASYGHVDVAALLIKYNA-CVNATDKWAFTPLHEAAQKG 756
Query: 1325 HYQMVEVLLGQGAEINATDKNGWTPL 1350
Q+ +LL GA+ ++ G TPL
Sbjct: 757 RTQLCALLLAHGADPTLKNQEGQTPL 782
Score = 137 bits (332), Expect = 3e-31
Identities = 185/739 (25%), Positives = 304/739 (41%), Gaps = 98/739 (13%)
Query: 729 QRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGG 788
++ TPLH AA D LL++GA + G+ P+H A FG+ + LLL G
Sbjct: 57 RKSTPLHFAAGFGRKDVVEY-LLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGA 115
Query: 789 DPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESV-STAFIDAVDEDG 847
DP + TPL A D+ L++ + + +D D
Sbjct: 116 DPNARDN-------WNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSA 168
Query: 848 ASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMT 907
+ L K + + + + + L+ +V+ ++ + A AG N V
Sbjct: 169 KAVLTGEYKKDELLESARSGNEEKMMALL-TPLNVNCHASDGRKSTPLHLA-AGYNRVKI 226
Query: 908 EMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALH 967
+ ADV A ++ + + PL AC GH ++ L+ + A V+ D+ + LH
Sbjct: 227 VQLLLQHGADV-HAKDKGDLV---PLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLH 282
Query: 968 LAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM-----I 1022
AA ++VC LL+ A + ++A+ LA + + + H+ +
Sbjct: 283 EAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREA 342
Query: 1023 DVLTLKK---------------QTPLHLAAAS---GQIEVCKLLLELGANIDATDELGQK 1064
DV +KK +T LH AAAS + ++C+LLL GANI+ +
Sbjct: 343 DVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLT 402
Query: 1065 PIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFD-RTGV 1123
P+H A++ +++VV++ + +H V A G T H AA G ++ L+ + +
Sbjct: 403 PLHVASEKAHNDVVEVVV-KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
Query: 1124 ISARN----KLNDSTPLQLAAEG---GHADVVRVLVRA----------------GASCTD 1160
IS + ++ + QL EG G+++ R L+ A +C D
Sbjct: 462 ISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRD 521
Query: 1161 ENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSH 1220
T +H AA + +V++ + + K GL PLH A YG E L+ H
Sbjct: 522 IEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKH 581
Query: 1221 VPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGY 1280
G V + A TPLH AA G + +LLL N +G
Sbjct: 582 --GAVVNVADLW-----------KFTPLHEAAAKGKYEICKLLLQHGA--DPTKKNRDGN 626
Query: 1281 NPLHLACFG---------GHMSIVGL----LLSR-----SAELLHSTDRHGK--TGLHIA 1320
PL L G G +++ L+R S + ++ D G+ T LH+A
Sbjct: 627 TPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLA 686
Query: 1321 STHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNC 1380
+ + + ++ E LL GA++NA DK G PLH AA GH++V LL + A +
Sbjct: 687 AGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAF 746
Query: 1381 APIWFAASENHNDVLEYLL 1399
P+ AA + + LL
Sbjct: 747 TPLHEAAQKGRTQLCALLL 765
Score = 116 bits (278), Expect = 1e-24
Identities = 151/557 (27%), Positives = 228/557 (40%), Gaps = 71/557 (12%)
Query: 933 LLIACHRGHMQLVNTLLTNHARVDVFDVEGRSA--LHLAAEHGYLQVCDALLTNKAFINS 990
L AC G ++ V L+T +V+ D GR + LH AA G V + LL N A + +
Sbjct: 28 LFEACRNGDVERVKRLVTPE-KVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQA 86
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
+ G LH A G+A +V L+R H A + TPLH AA G+I+VC +LL+
Sbjct: 87 RDDGGLIPLHNACSFGHAEVVNLLLR-HGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 145
Query: 1051 LGAN--IDATD-----ELGQKPIHAAAQNNYS--EVVQLFLQQHPNLVMAT--------- 1092
GA I TD +L A Y E+++ + +MA
Sbjct: 146 HGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCH 205
Query: 1093 TKDG--NTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRV 1150
DG +T H+AA VK+++ L++ + A++K D PL A GH +V +
Sbjct: 206 ASDGRKSTPLHLAAGYNRVKIVQLLLQHGAD--VHAKDK-GDLVPLHNACSYGHYEVTEL 262
Query: 1151 LVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRS-------TNTLRISSKKLGLTPL- 1202
LV+ GA + T +H AA V ++ S N S+ L TP
Sbjct: 263 LVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQL 322
Query: 1203 -HIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA---YNGNEN 1258
AY + ++ + T + + + +V ++ T LH AA Y +
Sbjct: 323 KERLAYEFKGHSLLQAAREADVT-RIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQ 381
Query: 1259 VVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH 1318
+ LLL G + + E PLH+A H +V +++ A++ ++ D G+T LH
Sbjct: 382 ICELLLRK-GANINEKTKEF-LTPLHVASEKAHNDVVEVVVKHEAKV-NALDNLGQTSLH 438
Query: 1319 IASTHGHYQMVEVLLGQGAEINATDKNGWTPLHC-------------------------- 1352
A+ GH Q +LL G + N G+T L
Sbjct: 439 RAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLE 498
Query: 1353 AAKAGHLNVVKLLCE-SGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDD 1411
AAKAG + VK LC + + P+ FAA N V+EYLL D + D
Sbjct: 499 AAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA-KDK 557
Query: 1412 KRFVYNLMVCSKNHNNI 1428
V CS H +
Sbjct: 558 GGLVPLHNACSYGHYEV 574
Score = 74.5 bits (175), Expect = 4e-12
Identities = 95/382 (24%), Positives = 153/382 (40%), Gaps = 33/382 (8%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G S+H AA GH+ LL G ++ + +TAL + E+ V+ LL G +
Sbjct: 433 GQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGISL 487
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
G + + L AA+ D + + TP+H AA + ++ +
Sbjct: 488 ---GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 544
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFI-- 840
LL+ G D K K G PL AC ++ L++ G V+ A +
Sbjct: 545 LLQHGADVHAKDK-------GGLVPLHNACSYGHYEVAELLVKH-----GAVVNVADLWK 592
Query: 841 -DAVDEDGASALHYACKVTKEEVKIPTA---DRQVVKCLIENGADVSLQTRHNHETAFHY 896
+ E A + CK+ + PT D L+++G D +Q + A
Sbjct: 593 FTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDG-DTDIQDLLRGDAALLD 651
Query: 897 CAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVD 956
A G + +S+ D + Q TPL +A ++++ LL + A V+
Sbjct: 652 AAKKG----CLARVKKLSSPDNVNCRDTQGRHS-TPLHLAAGYNNLEVAEYLLQHGADVN 706
Query: 957 VFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIR 1016
D G LH AA +G++ V L+ A +N+ + T LH AA G L L+
Sbjct: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLA 766
Query: 1017 DHNAMIDVLTLKKQTPLHLAAA 1038
H A + + QTPL L +A
Sbjct: 767 -HGADPTLKNQEGQTPLDLVSA 787
Score = 70.9 bits (166), Expect = 4e-11
Identities = 50/136 (36%), Positives = 64/136 (47%), Gaps = 4/136 (2%)
Query: 1266 SAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGK--TGLHIASTH 1323
+A A A + E L AC G + V L++ E ++S D G+ T LH A+
Sbjct: 11 AACASAAAEAVEPAARELFEACRNGDVERVKRLVT--PEKVNSRDTAGRKSTPLHFAAGF 68
Query: 1324 GHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPI 1383
G +VE LL GA + A D G PLH A GH VV LL GA P + N N P+
Sbjct: 69 GRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPL 128
Query: 1384 WFAASENHNDVLEYLL 1399
AA + DV LL
Sbjct: 129 HEAAIKGKIDVCIVLL 144
Score = 58.0 bits (134), Expect = 3e-07
Identities = 42/129 (32%), Positives = 62/129 (48%), Gaps = 3/129 (2%)
Query: 55 IRDLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMA 114
I+DL+ RG LL A + G + V++L S + T T LHLAA ++++A
Sbjct: 639 IQDLL--RGDAALLDAAKKGCLARVKKLSSPDNVN-CRDTQGRHSTPLHLAAGYNNLEVA 695
Query: 115 RILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAEN 174
L+ +GA V+A + G PLH AA+ G + A D TP+H AA+
Sbjct: 696 EYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQK 755
Query: 175 GHAAIIELL 183
G + LL
Sbjct: 756 GRTQLCALL 764
Score = 55.2 bits (127), Expect = 2e-06
Identities = 44/151 (29%), Positives = 70/151 (46%), Gaps = 3/151 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
LL A +AG+ V++L + Q+ + T LH AA V + L+ +GA V A
Sbjct: 496 LLEAAKAGDVETVKKLCTVQSVN-CRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA 554
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G PLH A + G + + A +AD TP+H AA G I +LL +
Sbjct: 555 KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLL-Q 613
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMML 217
A ++ +DG+T + + +G D +L
Sbjct: 614 HGADPTKKNRDGNTPLDLVK-DGDTDIQDLL 643
Score = 55.2 bits (127), Expect = 2e-06
Identities = 38/119 (31%), Positives = 56/119 (47%), Gaps = 2/119 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL LA N + LL Q + A G LH AA VD+A +L+ Y
Sbjct: 678 RHSTPLHLAAGYNNLEVAEYLL--QHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYN 735
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A V+AT+ TPLH AA +G L A+ + + E +TP+ L + + +A++
Sbjct: 736 ACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794
Score = 54.8 bits (126), Expect = 3e-06
Identities = 42/131 (32%), Positives = 59/131 (45%), Gaps = 3/131 (2%)
Query: 92 KATTPAGDTALHLAARRRDVDMARILVDYGAVVDA-TNGAGQTPLHIAAAEGDEPLVKYF 150
+A PA L A R DV+ + LV V T G TPLH AA G + +V+Y
Sbjct: 19 EAVEPAA-RELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYL 77
Query: 151 YGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
AN D+ P+H A GHA ++ LL + A R T +H A++ G
Sbjct: 78 LQNGANVQARDDGGLIPLHNACSFGHAEVVNLLL-RHGADPNARDNWNYTPLHEAAIKGK 136
Query: 211 ADCAMMLFKKG 221
D ++L + G
Sbjct: 137 IDVCIVLLQHG 147
Score = 44.8 bits (101), Expect = 0.003
Identities = 37/98 (37%), Positives = 46/98 (46%), Gaps = 4/98 (4%)
Query: 662 DGARS--IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYG 719
DG +S +H AA Y V I+ LLQ G V + LH A V E L+ +G
Sbjct: 208 DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 267
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
A V+ Q TPLH AA + C+L LL GA P
Sbjct: 268 ACVNAMDLWQ-FTPLHEAASKNRVEVCSL-LLSYGADP 303
Score = 44.4 bits (100), Expect = 0.004
Identities = 43/170 (25%), Positives = 69/170 (40%), Gaps = 6/170 (3%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL A G + +V LL Q ++A G LH A ++ +L+ +G
Sbjct: 57 RKSTPLHFAAGFGRKDVVEYLL--QNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHG 114
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE 181
A +A + TPLH AA +G + A I + + RT + LA + A
Sbjct: 115 ADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAV--- 171
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNG-HADCAMMLFKKGVYLHMPNKY 230
L + K + E + G+ +A L + +C +K LH+ Y
Sbjct: 172 LTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGY 221
Score = 42.3 bits (95), Expect = 0.018
Identities = 32/123 (26%), Positives = 47/123 (38%), Gaps = 1/123 (0%)
Query: 99 DTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAA 158
D L A + M +L A++G TPLH+AA +V+ A+
Sbjct: 179 DELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVH 238
Query: 159 IADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF 218
D D P+H A GH + ELL K A + T +H A+ + +L
Sbjct: 239 AKDKGDLVPLHNACSYGHYEVTELLV-KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 297
Query: 219 KKG 221
G
Sbjct: 298 SYG 300
Score = 39.1 bits (87), Expect = 0.17
Identities = 30/117 (25%), Positives = 51/117 (43%), Gaps = 4/117 (3%)
Query: 71 VEAGNQSMVRELLSAQTAEQLKATTP-AGDTALHLAARR---RDVDMARILVDYGAVVDA 126
++A ++ V + + E + P +TALH AA + + +L+ GA ++
Sbjct: 336 LQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINE 395
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
TPLH+A+ + +V+ A DN +T +H AA GH LL
Sbjct: 396 KTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452
Score = 35.5 bits (78), Expect = 2.1
Identities = 21/75 (28%), Positives = 35/75 (46%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T LH+A+ + D+ ++V + A V+A + GQT LH AA G + + I
Sbjct: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
Query: 160 ADNEDRTPMHLAAEN 174
+ T + + EN
Sbjct: 462 ISLQGFTALQMGNEN 476
Score = 33.5 bits (73), Expect = 8.3
Identities = 38/159 (23%), Positives = 66/159 (41%), Gaps = 10/159 (6%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL LA +V+ LL Q + A LH A ++ +LV +G
Sbjct: 210 RKSTPLHLAAGYNRVKIVQLLL--QHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 267
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE 181
A V+A + TPLH AA++ + A+ + + +++ + LA + E
Sbjct: 268 ACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPT---PQLKE 324
Query: 182 LLADKFKA-SIFERTKDGSTLMHIASLNGHADCAMMLFK 219
LA +FK S+ + ++ + + H M+ FK
Sbjct: 325 RLAYEFKGHSLLQAAREAD----VTRIKKHLSLEMVNFK 359
>AF305081-1|AAG25674.1| 1265|Homo sapiens tankyrase-related protein
protein.
Length = 1265
Score = 167 bits (406), Expect = 4e-40
Identities = 197/764 (25%), Positives = 320/764 (41%), Gaps = 92/764 (12%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H A +GH ++N LL+ G + N NYT LH A K V LL +GA+
Sbjct: 191 GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 250
Query: 723 HIRG-------------------GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATED 763
IR G+ ++ L +AR G++ +M L + N D
Sbjct: 251 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESAR--SGNEEKMMALLTPLNVNCHASD 308
Query: 764 GM--TPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVR 821
G TP+H+AA + + + LLL+ G D K K D+V PL AC ++
Sbjct: 309 GRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKG---DLV----PLHNACSYGHYEVTE 361
Query: 822 HLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGAD 881
L++ A ++A+D + LH A + EV L+ GAD
Sbjct: 362 LLVKH----------GACVNAMDLWQFTPLHEAASKNRVEV---------CSLLLSYGAD 402
Query: 882 VSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGH 941
+L HN ++A + E +A+ + A R+ + T + + H
Sbjct: 403 PTLLNCHN-KSAIDLAP----TPQLKERLAYEFQRPLVAAXAREADV--TRI-----KKH 450
Query: 942 MQLVNTLLTNHARVDVFDVEGRSALHLAAEHGY---LQVCDALLTNKAFINSKARNGRTA 998
+ L + + +ALH AA Y Q+C+ LL A IN K + T
Sbjct: 451 LSLEMVIQASQTH--------ETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTP 502
Query: 999 LHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDAT 1058
LH+A+ + +V+ +++ H A ++ L QT LH AA G ++ C+LLL G + +
Sbjct: 503 LHVASEKAHNDVVEVVVK-HEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNII 561
Query: 1059 DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKF 1118
G + +N VQ LQ+ +L + + AA G V+ +++L
Sbjct: 562 SLQGFTALQMGNEN-----VQQLLQEGISL---GNSEADRQLLEAAKAGDVETVKKLCTV 613
Query: 1119 DRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHT 1178
+ STPL AA VV L++ GA +++ GL +H A +GH
Sbjct: 614 QSVNCRDIEGR--QSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHY 671
Query: 1179 NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPV 1238
V +++ + + TPLH AA G+ E + LL H K L V
Sbjct: 672 EVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV 731
Query: 1239 LGAESGLTPLHL-------AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGH 1291
++ + L AA G V+ L + V + PLHLA +
Sbjct: 732 KDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHS-TPLHLAAGYNN 790
Query: 1292 MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLH 1351
+ + LL A++ ++ D+ G LH A+++GH + +L+ A +NATDK +TPLH
Sbjct: 791 LEVAEYLLQHGADV-NAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLH 849
Query: 1352 CAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVL 1395
AA+ G + LL GA P + P+ ++++ + +L
Sbjct: 850 EAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 893
Score = 150 bits (363), Expect = 6e-35
Identities = 180/687 (26%), Positives = 288/687 (41%), Gaps = 86/687 (12%)
Query: 737 AARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKV 796
AARI G +CA + +A E + A + G++ + L+ R T
Sbjct: 97 AARIMSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDT-- 154
Query: 797 CIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACK 856
TPL A D+V +L++ + A + A D+ G LH AC
Sbjct: 155 ----AGRKSTPLHFAAXFGRKDVVEYLLQ----------NGANVQARDDGGLIPLHNACS 200
Query: 857 VTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAH---- 912
EV V L+ +GAD + + N+ T H AI G DV ++ H
Sbjct: 201 FGHAEV---------VNLLLRHGADPNARDNWNY-TPLHEAAIKGKIDVCIVLLQHGAEP 250
Query: 913 ----------ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
+ AD S LL + G+ + + LLT V+ +G
Sbjct: 251 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTP-LNVNCHASDG 309
Query: 963 RSA--LHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
R + LHLAA + +++ LL + A +++K + LH A G+ + + L++ H A
Sbjct: 310 RKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK-HGA 368
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQL 1080
++ + L + TPLH AA+ ++EVC LLL GA+ + + I A E +
Sbjct: 369 CVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAY 428
Query: 1081 FLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAA 1140
Q+ LV A ++ A + I+ + +E +++ +T T L AA
Sbjct: 429 EFQRP--LVAAXARE----ADVTRIKKHLS-LEMVIQASQT----------HETALHCAA 471
Query: 1141 EGGHA---DVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKL 1197
+ + +L+R GA+ ++ + LT +H+A+E H +V++V+ + L
Sbjct: 472 ASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNL 531
Query: 1198 GLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNE 1257
G T LH AAY G +T R LLS+ P +SL G T L + GNE
Sbjct: 532 GQTSLHRAAYCGHLQTCRLLLSY------GCDPNIISL-------QGFTALQM----GNE 574
Query: 1258 NVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGL 1317
NV +LL G+ + N L A G + V L + + + T L
Sbjct: 575 NVQQLL--QEGI---SLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPL 629
Query: 1318 HIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETN 1377
H A+ + +VE LL GA+++A DK G PLH A GH V +LL + GA
Sbjct: 630 HFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADL 689
Query: 1378 LNCAPIWFAASENHNDVLEYLLHKEHD 1404
P+ AA++ ++ + LL D
Sbjct: 690 WKFTPLHEAAAKGKYEICKLLLQHGAD 716
Score = 134 bits (325), Expect = 2e-30
Identities = 185/738 (25%), Positives = 302/738 (40%), Gaps = 97/738 (13%)
Query: 729 QRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGG 788
++ TPLH AA D LL++GA + G+ P+H A FG+ + LLL G
Sbjct: 157 RKSTPLHFAAXFGRKDVVEY-LLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGA 215
Query: 789 DPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESV-STAFIDAVDEDG 847
DP + TPL A D+ L++ + + +D D
Sbjct: 216 DPNARDN-------WNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSA 268
Query: 848 ASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMT 907
+ L K + + + + + L+ +V+ ++ + A AG N V
Sbjct: 269 KAVLTGEYKKDELLESARSGNEEKMMALL-TPLNVNCHASDGRKSTPLHLA-AGYNRVKI 326
Query: 908 EMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALH 967
+ ADV A ++ + + PL AC GH ++ L+ + A V+ D+ + LH
Sbjct: 327 VQLLLQHGADV-HAKDKGDLV---PLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLH 382
Query: 968 LAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKF-----LIRDHNAMI 1022
AA ++VC LL+ A + ++A+ LA + + L+
Sbjct: 383 EAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFQRPLVAAXAREA 442
Query: 1023 DVLTLKK--------------QTPLHLAAAS---GQIEVCKLLLELGANIDATDELGQKP 1065
DV +KK +T LH AAAS + ++C+LLL GANI+ + P
Sbjct: 443 DVTRIKKHLSLEMVIQASQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTP 502
Query: 1066 IHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFD-RTGVI 1124
+H A++ +++VV++ + +H V A G T H AA G ++ L+ + +I
Sbjct: 503 LHVASEKAHNDVVEVVV-KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNII 561
Query: 1125 SARN----KLNDSTPLQLAAEG---GHADVVRVLVRA----------------GASCTDE 1161
S + ++ + QL EG G+++ R L+ A +C D
Sbjct: 562 SLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDI 621
Query: 1162 NRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
T +H AA + +V++ + + K GL PLH A YG E L+ H
Sbjct: 622 EGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKH- 680
Query: 1222 PGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYN 1281
G V + A TPLH AA G + +LLL N +G
Sbjct: 681 -GAVVNVADLW-----------KFTPLHEAAAKGKYEICKLLLQHGA--DPTKKNRDGNT 726
Query: 1282 PLHLACFG---------GHMSIVGL----LLSR-----SAELLHSTDRHGK--TGLHIAS 1321
PL L G G +++ L+R S + ++ D G+ T LH+A+
Sbjct: 727 PLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAA 786
Query: 1322 THGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCA 1381
+ + ++ E LL GA++NA DK G PLH AA GH++V LL + A +
Sbjct: 787 GYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFT 846
Query: 1382 PIWFAASENHNDVLEYLL 1399
P+ AA + + LL
Sbjct: 847 PLHEAAQKGRTQLCALLL 864
Score = 116 bits (279), Expect = 9e-25
Identities = 153/557 (27%), Positives = 228/557 (40%), Gaps = 72/557 (12%)
Query: 933 LLIACHRGHMQLVNTLLTNHARVDVFDVEGRSA--LHLAAEHGYLQVCDALLTNKAFINS 990
L AC G ++ V L+T +V+ D GR + LH AA G V + LL N A + +
Sbjct: 128 LFEACRNGDVERVKRLVTPE-KVNSRDTAGRKSTPLHFAAXFGRKDVVEYLLQNGANVQA 186
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
+ G LH A G+A +V L+R H A + TPLH AA G+I+VC +LL+
Sbjct: 187 RDDGGLIPLHNACSFGHAEVVNLLLR-HGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 245
Query: 1051 LGAN--IDATD-----ELGQKPIHAAAQNNYS--EVVQLFLQQHPNLVMAT--------- 1092
GA I TD +L A Y E+++ + +MA
Sbjct: 246 HGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCH 305
Query: 1093 TKDG--NTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRV 1150
DG +T H+AA VK+++ L++ + A++K D PL A GH +V +
Sbjct: 306 ASDGRKSTPLHLAAGYNRVKIVQLLLQHGAD--VHAKDK-GDLVPLHNACSYGHYEVTEL 362
Query: 1151 LVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRS-------TNTLRISSKKLGLTPL- 1202
LV+ GA + T +H AA V ++ S N S+ L TP
Sbjct: 363 LVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQL 422
Query: 1203 -HIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA---YNGNEN 1258
AY Q V T + + + +V + +++ T LH AA Y +
Sbjct: 423 KERLAYEFQRPLVAAXAREADVT-RIKKHLSLEMV-IQASQTHETALHCAAASPYPKRKQ 480
Query: 1259 VVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH 1318
+ LLL G + + E PLH+A H +V +++ A++ ++ D G+T LH
Sbjct: 481 ICELLLRK-GANINEKTKEF-LTPLHVASEKAHNDVVEVVVKHEAKV-NALDNLGQTSLH 537
Query: 1319 IASTHGHYQMVEVLLGQGAEINATDKNGWTPLHC-------------------------- 1352
A+ GH Q +LL G + N G+T L
Sbjct: 538 RAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLE 597
Query: 1353 AAKAGHLNVVKLLCE-SGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDD 1411
AAKAG + VK LC + + P+ FAA N V+EYLL D + D
Sbjct: 598 AAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA-KDK 656
Query: 1412 KRFVYNLMVCSKNHNNI 1428
V CS H +
Sbjct: 657 GGLVPLHNACSYGHYEV 673
Score = 109 bits (262), Expect = 1e-22
Identities = 163/612 (26%), Positives = 263/612 (42%), Gaps = 72/612 (11%)
Query: 662 DGARS--IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYG 719
DG +S +H AA Y V I+ LLQ G V + LH A V E L+ +G
Sbjct: 308 DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 367
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP------NKATED-GMTP---VH 769
A V+ Q TPLH AA + C+L LL GA P NK+ D TP
Sbjct: 368 ACVNAMDLWQ-FTPLHEAASKNRVEVCSL-LLSYGADPTLLNCHNKSAIDLAPTPQLKER 425
Query: 770 VAAKFGNLATLVLLLEDGGDPLRK---TKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
+A +F E ++K ++ I T ET L A S P + + E
Sbjct: 426 LAYEFQRPLVAAXAREADVTRIKKHLSLEMVIQASQTHETALHCAAASPYPK-RKQICEL 484
Query: 827 VKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQT 886
+ KG A I+ ++ + LH A + A VV+ ++++ A V+
Sbjct: 485 LL-RKG-----ANINEKTKEFLTPLHVASE---------KAHNDVVEVVVKHEAKVNALD 529
Query: 887 RHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVN 946
+T+ H A G+ ++++ ++ ++ Q G+T L + L
Sbjct: 530 NLG-QTSLHRAAYCGHLQTCRLLLSYGCDPNI---ISLQ---GFTALQMGNENVQQLLQE 582
Query: 947 TLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGR--TALHLAAM 1004
+ ++ D R L AA+ G ++ L T ++ +N + GR T LH AA
Sbjct: 583 GISLGNSEAD------RQLLE-AAKAGDVETVKKLCTVQS-VNCRDIEGRQSTPLHFAAG 634
Query: 1005 NGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQK 1064
+V++L++ H A + PLH A + G EV +LL++ GA ++ D
Sbjct: 635 YNRVSVVEYLLQ-HGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFT 693
Query: 1065 PIHAAAQNNYSEVVQLFLQ---------QHPNLVMATTKDGNTCAHIAAIQGSVKVIEEL 1115
P+H AA E+ +L LQ + N + KDG+T ++G +++
Sbjct: 694 PLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQ-DLLRGDAALLDAA 752
Query: 1116 MK--FDRTGVISARNKLN-------DSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGL 1166
K R +S+ + +N STPL LAA + +V L++ GA +++ GL
Sbjct: 753 KKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGL 812
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTV 1225
+H AA +GH +V ++ N ++ K TPLH AA G+ + LL+H T+
Sbjct: 813 IPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTL 872
Query: 1226 KS-EAPTGVSLV 1236
K+ E T + LV
Sbjct: 873 KNQEGQTPLDLV 884
Score = 58.0 bits (134), Expect = 3e-07
Identities = 42/129 (32%), Positives = 62/129 (48%), Gaps = 3/129 (2%)
Query: 55 IRDLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMA 114
I+DL+ RG LL A + G + V++L S + T T LHLAA ++++A
Sbjct: 738 IQDLL--RGDAALLDAAKKGCLARVKKLSSPDNVN-CRDTQGRHSTPLHLAAGYNNLEVA 794
Query: 115 RILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAEN 174
L+ +GA V+A + G PLH AA+ G + A D TP+H AA+
Sbjct: 795 EYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQK 854
Query: 175 GHAAIIELL 183
G + LL
Sbjct: 855 GRTQLCALL 863
Score = 56.0 bits (129), Expect = 1e-06
Identities = 50/159 (31%), Positives = 69/159 (43%), Gaps = 6/159 (3%)
Query: 67 LLLAVEAGNQSMVRELL---SAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
LLLAV A R +A + +A PA L A R DV+ + LV V
Sbjct: 91 LLLAVAAARIMSGRRCAGGGAACASAAAEAVEPAA-RELFEACRNGDVERVKRLVTPEKV 149
Query: 124 VDA-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
T G TPLH AA G + +V+Y AN D+ P+H A GHA ++ L
Sbjct: 150 NSRDTAGRKSTPLHFAAXFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNL 209
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L + A R T +H A++ G D ++L + G
Sbjct: 210 LL-RHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG 247
Score = 55.2 bits (127), Expect = 2e-06
Identities = 44/151 (29%), Positives = 70/151 (46%), Gaps = 3/151 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
LL A +AG+ V++L + Q+ + T LH AA V + L+ +GA V A
Sbjct: 595 LLEAAKAGDVETVKKLCTVQSVN-CRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA 653
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G PLH A + G + + A +AD TP+H AA G I +LL +
Sbjct: 654 KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLL-Q 712
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMML 217
A ++ +DG+T + + +G D +L
Sbjct: 713 HGADPTKKNRDGNTPLDLVK-DGDTDIQDLL 742
Score = 55.2 bits (127), Expect = 2e-06
Identities = 38/119 (31%), Positives = 56/119 (47%), Gaps = 2/119 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL LA N + LL Q + A G LH AA VD+A +L+ Y
Sbjct: 777 RHSTPLHLAAGYNNLEVAEYLL--QHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYN 834
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A V+AT+ TPLH AA +G L A+ + + E +TP+ L + + +A++
Sbjct: 835 ACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 893
Score = 54.0 bits (124), Expect = 5e-06
Identities = 37/105 (35%), Positives = 50/105 (47%), Gaps = 2/105 (1%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA +G ++ LLQ G +V + LH A VV LL +GAD + R
Sbjct: 162 LHFAAXFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNAR- 220
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVA 771
TPLH AA D C ++LL+ GA P DG T + +A
Sbjct: 221 DNWNYTPLHEAAIKGKIDVC-IVLLQHGAEPTIRNTDGRTALDLA 264
Score = 42.3 bits (95), Expect = 0.018
Identities = 32/123 (26%), Positives = 47/123 (38%), Gaps = 1/123 (0%)
Query: 99 DTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAA 158
D L A + M +L A++G TPLH+AA +V+ A+
Sbjct: 279 DELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVH 338
Query: 159 IADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF 218
D D P+H A GH + ELL K A + T +H A+ + +L
Sbjct: 339 AKDKGDLVPLHNACSYGHYEVTELLV-KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 397
Query: 219 KKG 221
G
Sbjct: 398 SYG 400
Score = 39.5 bits (88), Expect = 0.13
Identities = 29/118 (24%), Positives = 49/118 (41%), Gaps = 3/118 (2%)
Query: 69 LAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARR---RDVDMARILVDYGAVVD 125
L ++ V + + E + + +TALH AA + + +L+ GA ++
Sbjct: 434 LVAAXAREADVTRIKKHLSLEMVIQASQTHETALHCAAASPYPKRKQICELLLRKGANIN 493
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
TPLH+A+ + +V+ A DN +T +H AA GH LL
Sbjct: 494 EKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 551
Score = 35.5 bits (78), Expect = 2.1
Identities = 21/75 (28%), Positives = 35/75 (46%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T LH+A+ + D+ ++V + A V+A + GQT LH AA G + + I
Sbjct: 501 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 560
Query: 160 ADNEDRTPMHLAAEN 174
+ T + + EN
Sbjct: 561 ISLQGFTALQMGNEN 575
>BC112351-1|AAI12352.1| 725|Homo sapiens INVS protein protein.
Length = 725
Score = 165 bits (402), Expect = 1e-39
Identities = 141/512 (27%), Positives = 230/512 (44%), Gaps = 28/512 (5%)
Query: 895 HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
H A+ G+ + +I S ++++ G TPL+ + + LL A
Sbjct: 19 HAAAVNGDKGALQRLIVGNSALK-----DKEDQFGRTPLMYCVLADRLDCADALLKAGAD 73
Query: 955 VDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
V+ D R+ALHLAA+ G + LLT +A K T LHL + + L
Sbjct: 74 VNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALL 133
Query: 1015 IRDHN-AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN- 1072
++ +D KQT LH +A E KLL++ +NI D G+ P+H AA +
Sbjct: 134 LKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHK 193
Query: 1073 --NYSEVVQLFLQQHPNLVMATTKD--GNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
+ V+ L P + +D G T H A G+V V++ L ++ + S N
Sbjct: 194 DPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDN 253
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCT-DENRAGLTAVHLAAEHGHTNVLDVMRST 1187
TPL AA GHA +V +L+ S T + G T +H AA+ + V
Sbjct: 254 LFR--TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+++ S G T AA G + +R +LS +KS+ ++ + G T
Sbjct: 312 PSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLS-----LKSDIDINMA------DKYGGTA 360
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH AA +G+ + V+LLL + Q DA ++ + PL AC GH ++ L+ A +
Sbjct: 361 LHAAALSGHVSTVKLLLEN-NAQVDA-TDVMKHTPLFRACEMGHKDVIQTLIKGGARV-D 417
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
D+ G + LH A+ G+ + ++L+ N D G TPL CAA G++N + +L E
Sbjct: 418 LVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME 477
Query: 1368 SGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+ A P + + ++ + + D ++ LL
Sbjct: 478 NNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 147 bits (355), Expect = 6e-34
Identities = 136/470 (28%), Positives = 209/470 (44%), Gaps = 27/470 (5%)
Query: 944 LVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAA 1003
L ++ N A D D GR+ L L DALL A +N + RTALHLAA
Sbjct: 30 LQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAA 89
Query: 1004 MNGYAHLVKFLI-RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDE 1060
G +K L+ R N M L++ TPLHL + LLL+ A +D D+
Sbjct: 90 QKGNYRFMKLLLTRRANWMQK--DLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDK 147
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQ---GSVKVIEELMK 1117
Q +H +A N E V+L ++ N+ + +G H AA +V + ++
Sbjct: 148 NKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV-EGKIPLHWAANHKDPSAVHTVRCILD 206
Query: 1118 FDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR-AGASCTDENRAGLTAVHLAAEHG 1176
T + TPL A G+ VV VL + T + T +H AA G
Sbjct: 207 AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLG 266
Query: 1177 HTNVLDVMRSTNTL-RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSL 1235
H ++ ++ N I S G TPLH AA AETV+ L H +VK ++
Sbjct: 267 HAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP--SVKDDSDL---- 320
Query: 1236 VPVLGAESGLTPLHLAAYNGNENVVRLLLN-SAGVQADAASNENGYNPLHLACFGGHMSI 1294
G T AA G+++V+R +L+ + + + A G LH A GH+S
Sbjct: 321 -------EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGG-TALHAAALSGHVST 372
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
V LLL +A++ +TD T L A GH +++ L+ GA ++ D++G + LH AA
Sbjct: 373 VKLLLENNAQV-DATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAA 431
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G+ +V ++L E+ +P + P+ AA + + + L+ D
Sbjct: 432 LGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNAD 481
Score = 130 bits (315), Expect = 4e-29
Identities = 141/521 (27%), Positives = 234/521 (44%), Gaps = 38/521 (7%)
Query: 703 AVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATE 762
AV K A+ ++G A + + + TPL + D CA LLK+GA NK
Sbjct: 22 AVNGDKGALQRLIVGNSA-LKDKEDQFGRTPLMYCV-LADRLDCADALLKAGADVNKTDH 79
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
T +H+AA+ GN + LLL + ++K + TPL + R P +
Sbjct: 80 SQRTALHLAAQKGNYRFMKLLLTRRANWMQKD-------LEEMTPLHLTTRHRSPKCLAL 132
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L++F+ GE +D D++ +ALH++ E VK LI++ +++
Sbjct: 133 LLKFMA--PGE------VDTQDKNKQTALHWSAYYNNPE---------HVKLLIKHDSNI 175
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ + H+ A + + + + A LN Q+ G TPL A G++
Sbjct: 176 GIPDVEG-KIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNV 234
Query: 943 QLVNTLLT-NHARVDVFDVEGRSALHLAAEHGYLQVCDALL-TNKAFINSKARNGRTALH 1000
+V+ L + + +D R+ LH AA G+ Q+ LL NK+ G T LH
Sbjct: 235 TVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLH 294
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID--AT 1058
AA + +A VK ++ H ++ D L+ +T AA G +V + +L L ++ID
Sbjct: 295 YAAQSNFAETVKVFLK-HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMA 353
Query: 1059 DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKF 1118
D+ G +HAAA + + V+L L+ + V AT +T A G VI+ L+K
Sbjct: 354 DKYGGTALHAAALSGHVSTVKLLLENNAQ-VDATDVMKHTPLFRACEMGHKDVIQTLIKG 412
Query: 1119 D-RTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGH 1177
R ++ + + L AA GG+ADV ++L+ + ++ AG T + AA G+
Sbjct: 413 GARVDLVDQ----DGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 468
Query: 1178 TNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
N + V+ N K G T LH + G + ++ LL
Sbjct: 469 INCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 127 bits (307), Expect = 4e-28
Identities = 123/451 (27%), Positives = 201/451 (44%), Gaps = 32/451 (7%)
Query: 964 SALHLAAEHGYLQVCDALLT-NKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
S +H AA +G L+ N A + + + GRT L + L++ A +
Sbjct: 16 SQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKA-GADV 74
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
+ ++T LHLAA G KLLL AN D P+H ++ + + L L
Sbjct: 75 NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL 134
Query: 1083 Q-QHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT-GVISARNKLNDSTPLQLAA 1140
+ P V K+ T H +A + + ++ L+K D G+ K+ PL AA
Sbjct: 135 KFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKI----PLHWAA 190
Query: 1141 ---EGGHADVVRVLVRAGAS---CTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISS 1194
+ VR ++ A + ++ G T +H A G+ V+DV+ S + I+S
Sbjct: 191 NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITS 250
Query: 1195 -KKLGLTPLHIAAYYGQAETVRELLS-HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
L TPLH AA G A+ V LL + GT+ S++ G TPLH AA
Sbjct: 251 YDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS-------------QGATPLHYAA 297
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL-LHSTDR 1311
+ V++ L V+ D S+ G A G ++ +LS +++ ++ D+
Sbjct: 298 QSNFAETVKVFLKHPSVKDD--SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADK 355
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGAS 1371
+G T LH A+ GH V++LL A+++ATD TPL A + GH +V++ L + GA
Sbjct: 356 YGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGAR 415
Query: 1372 PKSETNLNCAPIWFAASENHNDVLEYLLHKE 1402
+ + +AA + DV + L+ +
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENK 446
Score = 122 bits (294), Expect = 1e-26
Identities = 124/479 (25%), Positives = 215/479 (44%), Gaps = 40/479 (8%)
Query: 680 NTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAAR 739
+ LL+ G V+ T + TALH+A + ++ LL A+ ++ + TPLH+ R
Sbjct: 65 DALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRAN-WMQKDLEEMTPLHLTTR 123
Query: 740 IPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVC 797
KC +LLK A T+D T +H +A + N + LL++ + +
Sbjct: 124 -HRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIK------HDSNIG 176
Query: 798 IYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKV 857
I D V G+ PL A P V H + + D + + + ++ D +G + LH+A V
Sbjct: 177 IPD-VEGKIPLHWAANHKDPSAV-HTVRCILD---AAPTESLLNWQDYEGRTPLHFA--V 229
Query: 858 TKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTAD 917
V + C I + ++ T H+ A+ G+ ++ ++ +
Sbjct: 230 ADGNVTVVDVLTSYESCNITSYDNL-------FRTPLHWAALLGHAQIVHLLLERNKSGT 282
Query: 918 VSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQV 977
+ +S G TPL A + V L + + D D+EGR++ AA G V
Sbjct: 283 IP-----SDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDV 337
Query: 978 CDALLTNKA--FINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHL 1035
+L+ K+ IN + G TALH AA++G+ VK L+ ++NA +D + K TPL
Sbjct: 338 LRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL-ENNAQVDATDVMKHTPLFR 396
Query: 1036 AAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKD 1095
A G +V + L++ GA +D D+ G +H AA ++V Q+ ++ N + +D
Sbjct: 397 ACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIE---NKINPNVQD 453
Query: 1096 --GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
G T AA G + + LM+ + I + T L + G+ D +++L+
Sbjct: 454 YAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK---EGRTALHWSCNNGYLDAIKLLL 509
Score = 118 bits (285), Expect = 2e-25
Identities = 117/439 (26%), Positives = 199/439 (45%), Gaps = 43/439 (9%)
Query: 666 SIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVET---LLGYGADV 722
++H +A Y + + L++ ++ + + LH A P+ V T +L
Sbjct: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTE 211
Query: 723 HIRGGKQRE--TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLA 778
+ + E TPLH A + DG+ + +L S N + D + TP+H AA G+
Sbjct: 212 SLLNWQDYEGRTPLHFA--VADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQ 269
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LLLE R I G TPL A +S + V+ + K SV
Sbjct: 270 IVHLLLE------RNKSGTIPSDSQGATPLHYAAQSNFAETVKVFL------KHPSVK-- 315
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
D D +G ++ +A ++V R ++ +++ D+++ ++ TA H A
Sbjct: 316 --DDSDLEGRTSFMWAAGKGSDDVL-----RTMLS--LKSDIDINMADKYGG-TALHAAA 365
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVF 958
++G+ + ++ + + D + + TPL AC GH ++ TL+ ARVD+
Sbjct: 366 LSGHVSTVKLLLENNAQVDATDVMKH------TPLFRACEMGHKDVIQTLIKGGARVDLV 419
Query: 959 DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH 1018
D +G S LH AA G VC L+ NK N + GRT L AA GY + + L+ ++
Sbjct: 420 DQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM-EN 478
Query: 1019 NAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDELGQKPIHAAAQNNYSE 1076
NA ++ + +T LH + +G ++ KLLL+ A N +E P+ A E
Sbjct: 479 NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHE 538
Query: 1077 VVQLFLQQHPNLVMATTKD 1095
V+Q F+ +H L +A +D
Sbjct: 539 VIQ-FMLEHGALSIAAIQD 556
Score = 68.1 bits (159), Expect = 3e-10
Identities = 49/164 (29%), Positives = 78/164 (47%), Gaps = 9/164 (5%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H AA GHV + LL+ VD T +T L A E V++TL+ GA V
Sbjct: 357 GGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARV 416
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + + LH AA + D C + L+++ PN G TP+ AA G + + +
Sbjct: 417 DL-VDQDGHSLLHWAALGGNADVCQI-LIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
L+E+ DP + K G T L +C + D ++ L++F
Sbjct: 475 LMENNADPNIQDK-------EGRTALHWSCNNGYLDAIKLLLDF 511
Score = 64.5 bits (150), Expect = 4e-09
Identities = 41/167 (24%), Positives = 79/167 (47%), Gaps = 1/167 (0%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ + A G+ ++R +LS ++ + G TALH AA V ++L++ A
Sbjct: 322 GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNA 381
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VDAT+ TPL A G + +++ A + D + + +H AA G+A + ++
Sbjct: 382 QVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQI 441
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L + K + + G T + A+ G+ +C +L + ++ +K
Sbjct: 442 LIEN-KINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK 487
Score = 62.1 bits (144), Expect = 2e-08
Identities = 41/129 (31%), Positives = 60/129 (46%), Gaps = 7/129 (5%)
Query: 98 GDTALHLAARRRD---VDMARILVDYGAVVDATNGA---GQTPLHIAAAEGDEPLVKYFY 151
G LH AA +D V R ++D N G+TPLH A A+G+ +V
Sbjct: 182 GKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLT 241
Query: 152 GVRA-NAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
+ N DN RTP+H AA GHA I+ LL ++ K+ G+T +H A+ +
Sbjct: 242 SYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNF 301
Query: 211 ADCAMMLFK 219
A+ + K
Sbjct: 302 AETVKVFLK 310
Score = 56.0 bits (129), Expect = 1e-06
Identities = 46/173 (26%), Positives = 75/173 (43%), Gaps = 3/173 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A +G+ S V+ LL + Q+ AT T L A D+ + L+ GA
Sbjct: 357 GGTALHAAALSGHVSTVKLLL--ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGA 414
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VD + G + LH AA G+ + + + N + D RTP+ AA G+ + +
Sbjct: 415 RVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQT 235
L + A + K+G T +H + NG+ D +L + + E+ T
Sbjct: 475 LMEN-NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYT 526
Score = 53.6 bits (123), Expect = 7e-06
Identities = 57/196 (29%), Positives = 86/196 (43%), Gaps = 21/196 (10%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY--TALHIAVESCKPAVVETLLGYG 719
+G S AA G ++ T+L +D+ D Y TALH A S + V+ LL
Sbjct: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
A V + TPL A + D L+K GA + +DG + +H AA GN
Sbjct: 381 AQVDAT-DVMKHTPLFRACEMGHKD-VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV 438
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF 839
+L+E+ +P V Y G TPLQ A + + L+E + A
Sbjct: 439 CQILIENKINP----NVQDY---AGRTPLQCAAYGGYINCMAVLME----------NNAD 481
Query: 840 IDAVDEDGASALHYAC 855
+ D++G +ALH++C
Sbjct: 482 PNIQDKEGRTALHWSC 497
Score = 52.4 bits (120), Expect = 2e-05
Identities = 40/160 (25%), Positives = 74/160 (46%), Gaps = 4/160 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL A G+ +V LL + + + + G T LH AA+ + ++ + + +V
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ-GATPLHYAAQSNFAETVKVFLKHPSV 314
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI--ADNEDRTPMHLAAENGHAAIIE 181
D ++ G+T AA +G + +++ ++++ I AD T +H AA +GH + ++
Sbjct: 315 KDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVK 374
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LL + A + T + A GH D L K G
Sbjct: 375 LLLEN-NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGG 413
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/157 (26%), Positives = 74/157 (47%), Gaps = 4/157 (2%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQT 133
G++ ++ L+ +A + K G T L +D A L+ GA V+ T+ + +T
Sbjct: 25 GDKGALQRLIVGNSALKDKEDQ-FGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRT 83
Query: 134 PLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKA--SI 191
LH+AA +G+ +K RAN D E+ TP+HL + + LL KF A +
Sbjct: 84 ALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL-KFMAPGEV 142
Query: 192 FERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
+ K+ T +H ++ + + +L K + +P+
Sbjct: 143 DTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPD 179
Score = 49.6 bits (113), Expect = 1e-04
Identities = 38/161 (23%), Positives = 67/161 (41%), Gaps = 6/161 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL L + + LL ++ TALH +A + + ++L+ + + +
Sbjct: 117 PLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIG 176
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIA------DNEDRTPMHLAAENGHAAI 179
+ G+ PLH AA D V + A D E RTP+H A +G+ +
Sbjct: 177 IPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTV 236
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+++L +I T +H A+L GHA +L ++
Sbjct: 237 VDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLER 277
>BC111761-1|AAI11762.1| 1065|Homo sapiens inversin, isoform a protein.
Length = 1065
Score = 165 bits (402), Expect = 1e-39
Identities = 141/512 (27%), Positives = 230/512 (44%), Gaps = 28/512 (5%)
Query: 895 HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
H A+ G+ + +I S ++++ G TPL+ + + LL A
Sbjct: 19 HAAAVNGDKGALQRLIVGNSALK-----DKEDQFGRTPLMYCVLADRLDCADALLKAGAD 73
Query: 955 VDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
V+ D R+ALHLAA+ G + LLT +A K T LHL + + L
Sbjct: 74 VNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALL 133
Query: 1015 IRDHN-AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN- 1072
++ +D KQT LH +A E KLL++ +NI D G+ P+H AA +
Sbjct: 134 LKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHK 193
Query: 1073 --NYSEVVQLFLQQHPNLVMATTKD--GNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
+ V+ L P + +D G T H A G+V V++ L ++ + S N
Sbjct: 194 DPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDN 253
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCT-DENRAGLTAVHLAAEHGHTNVLDVMRST 1187
TPL AA GHA +V +L+ S T + G T +H AA+ + V
Sbjct: 254 LFR--TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+++ S G T AA G + +R +LS +KS+ ++ + G T
Sbjct: 312 PSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLS-----LKSDIDINMA------DKYGGTA 360
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH AA +G+ + V+LLL + Q DA ++ + PL AC GH ++ L+ A +
Sbjct: 361 LHAAALSGHVSTVKLLLEN-NAQVDA-TDVMKHTPLFRACEMGHKDVIQTLIKGGARV-D 417
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
D+ G + LH A+ G+ + ++L+ N D G TPL CAA G++N + +L E
Sbjct: 418 LVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME 477
Query: 1368 SGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+ A P + + ++ + + D ++ LL
Sbjct: 478 NNADPNIQDQEGRTALHWSCNNGYLDAIKLLL 509
Score = 147 bits (355), Expect = 6e-34
Identities = 136/470 (28%), Positives = 209/470 (44%), Gaps = 27/470 (5%)
Query: 944 LVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAA 1003
L ++ N A D D GR+ L L DALL A +N + RTALHLAA
Sbjct: 30 LQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAA 89
Query: 1004 MNGYAHLVKFLI-RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDE 1060
G +K L+ R N M L++ TPLHL + LLL+ A +D D+
Sbjct: 90 QKGNYRFMKLLLTRRANWMQK--DLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDK 147
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQ---GSVKVIEELMK 1117
Q +H +A N E V+L ++ N+ + +G H AA +V + ++
Sbjct: 148 NKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV-EGKIPLHWAANHKDPSAVHTVRCILD 206
Query: 1118 FDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR-AGASCTDENRAGLTAVHLAAEHG 1176
T + TPL A G+ VV VL + T + T +H AA G
Sbjct: 207 AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLG 266
Query: 1177 HTNVLDVMRSTNTL-RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSL 1235
H ++ ++ N I S G TPLH AA AETV+ L H +VK ++
Sbjct: 267 HAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP--SVKDDSDL---- 320
Query: 1236 VPVLGAESGLTPLHLAAYNGNENVVRLLLN-SAGVQADAASNENGYNPLHLACFGGHMSI 1294
G T AA G+++V+R +L+ + + + A G LH A GH+S
Sbjct: 321 -------EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGG-TALHAAALSGHVST 372
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
V LLL +A++ +TD T L A GH +++ L+ GA ++ D++G + LH AA
Sbjct: 373 VKLLLENNAQV-DATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAA 431
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G+ +V ++L E+ +P + P+ AA + + + L+ D
Sbjct: 432 LGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNAD 481
Score = 129 bits (311), Expect = 1e-28
Identities = 140/521 (26%), Positives = 234/521 (44%), Gaps = 38/521 (7%)
Query: 703 AVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATE 762
AV K A+ ++G A + + + TPL + D CA LLK+GA NK
Sbjct: 22 AVNGDKGALQRLIVGNSA-LKDKEDQFGRTPLMYCV-LADRLDCADALLKAGADVNKTDH 79
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
T +H+AA+ GN + LLL + ++K + TPL + R P +
Sbjct: 80 SQRTALHLAAQKGNYRFMKLLLTRRANWMQKD-------LEEMTPLHLTTRHRSPKCLAL 132
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L++F+ GE +D D++ +ALH++ E VK LI++ +++
Sbjct: 133 LLKFMA--PGE------VDTQDKNKQTALHWSAYYNNPE---------HVKLLIKHDSNI 175
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ + H+ A + + + + A LN Q+ G TPL A G++
Sbjct: 176 GIPDVEG-KIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNV 234
Query: 943 QLVNTLLT-NHARVDVFDVEGRSALHLAAEHGYLQVCDALL-TNKAFINSKARNGRTALH 1000
+V+ L + + +D R+ LH AA G+ Q+ LL NK+ G T LH
Sbjct: 235 TVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLH 294
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID--AT 1058
AA + +A VK ++ H ++ D L+ +T AA G +V + +L L ++ID
Sbjct: 295 YAAQSNFAETVKVFLK-HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMA 353
Query: 1059 DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKF 1118
D+ G +HAAA + + V+L L+ + V AT +T A G VI+ L+K
Sbjct: 354 DKYGGTALHAAALSGHVSTVKLLLENNAQ-VDATDVMKHTPLFRACEMGHKDVIQTLIKG 412
Query: 1119 D-RTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGH 1177
R ++ + + L AA GG+ADV ++L+ + ++ AG T + AA G+
Sbjct: 413 GARVDLVDQ----DGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 468
Query: 1178 TNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
N + V+ N + G T LH + G + ++ LL
Sbjct: 469 INCMAVLMENNADPNIQDQEGRTALHWSCNNGYLDAIKLLL 509
Score = 127 bits (307), Expect = 4e-28
Identities = 123/451 (27%), Positives = 201/451 (44%), Gaps = 32/451 (7%)
Query: 964 SALHLAAEHGYLQVCDALLT-NKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
S +H AA +G L+ N A + + + GRT L + L++ A +
Sbjct: 16 SQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKA-GADV 74
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
+ ++T LHLAA G KLLL AN D P+H ++ + + L L
Sbjct: 75 NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL 134
Query: 1083 Q-QHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT-GVISARNKLNDSTPLQLAA 1140
+ P V K+ T H +A + + ++ L+K D G+ K+ PL AA
Sbjct: 135 KFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKI----PLHWAA 190
Query: 1141 ---EGGHADVVRVLVRAGAS---CTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISS 1194
+ VR ++ A + ++ G T +H A G+ V+DV+ S + I+S
Sbjct: 191 NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITS 250
Query: 1195 -KKLGLTPLHIAAYYGQAETVRELLS-HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
L TPLH AA G A+ V LL + GT+ S++ G TPLH AA
Sbjct: 251 YDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS-------------QGATPLHYAA 297
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL-LHSTDR 1311
+ V++ L V+ D S+ G A G ++ +LS +++ ++ D+
Sbjct: 298 QSNFAETVKVFLKHPSVKDD--SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADK 355
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGAS 1371
+G T LH A+ GH V++LL A+++ATD TPL A + GH +V++ L + GA
Sbjct: 356 YGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGAR 415
Query: 1372 PKSETNLNCAPIWFAASENHNDVLEYLLHKE 1402
+ + +AA + DV + L+ +
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENK 446
Score = 122 bits (293), Expect = 2e-26
Identities = 124/479 (25%), Positives = 215/479 (44%), Gaps = 40/479 (8%)
Query: 680 NTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAAR 739
+ LL+ G V+ T + TALH+A + ++ LL A+ ++ + TPLH+ R
Sbjct: 65 DALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRAN-WMQKDLEEMTPLHLTTR 123
Query: 740 IPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVC 797
KC +LLK A T+D T +H +A + N + LL++ + +
Sbjct: 124 -HRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIK------HDSNIG 176
Query: 798 IYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKV 857
I D V G+ PL A P V H + + D + + + ++ D +G + LH+A V
Sbjct: 177 IPD-VEGKIPLHWAANHKDPSAV-HTVRCILD---AAPTESLLNWQDYEGRTPLHFA--V 229
Query: 858 TKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTAD 917
V + C I + ++ T H+ A+ G+ ++ ++ +
Sbjct: 230 ADGNVTVVDVLTSYESCNITSYDNL-------FRTPLHWAALLGHAQIVHLLLERNKSGT 282
Query: 918 VSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQV 977
+ +S G TPL A + V L + + D D+EGR++ AA G V
Sbjct: 283 IP-----SDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDV 337
Query: 978 CDALLTNKA--FINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHL 1035
+L+ K+ IN + G TALH AA++G+ VK L+ ++NA +D + K TPL
Sbjct: 338 LRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL-ENNAQVDATDVMKHTPLFR 396
Query: 1036 AAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKD 1095
A G +V + L++ GA +D D+ G +H AA ++V Q+ ++ N + +D
Sbjct: 397 ACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIE---NKINPNVQD 453
Query: 1096 --GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
G T AA G + + LM+ + I + T L + G+ D +++L+
Sbjct: 454 YAGRTPLQCAAYGGYINCMAVLMENNADPNIQDQ---EGRTALHWSCNNGYLDAIKLLL 509
Score = 118 bits (285), Expect = 2e-25
Identities = 117/439 (26%), Positives = 199/439 (45%), Gaps = 43/439 (9%)
Query: 666 SIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVET---LLGYGADV 722
++H +A Y + + L++ ++ + + LH A P+ V T +L
Sbjct: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTE 211
Query: 723 HIRGGKQRE--TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLA 778
+ + E TPLH A + DG+ + +L S N + D + TP+H AA G+
Sbjct: 212 SLLNWQDYEGRTPLHFA--VADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQ 269
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LLLE R I G TPL A +S + V+ + K SV
Sbjct: 270 IVHLLLE------RNKSGTIPSDSQGATPLHYAAQSNFAETVKVFL------KHPSVK-- 315
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
D D +G ++ +A ++V R ++ +++ D+++ ++ TA H A
Sbjct: 316 --DDSDLEGRTSFMWAAGKGSDDVL-----RTMLS--LKSDIDINMADKYGG-TALHAAA 365
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVF 958
++G+ + ++ + + D + + TPL AC GH ++ TL+ ARVD+
Sbjct: 366 LSGHVSTVKLLLENNAQVDATDVMKH------TPLFRACEMGHKDVIQTLIKGGARVDLV 419
Query: 959 DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH 1018
D +G S LH AA G VC L+ NK N + GRT L AA GY + + L+ ++
Sbjct: 420 DQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM-EN 478
Query: 1019 NAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDELGQKPIHAAAQNNYSE 1076
NA ++ + +T LH + +G ++ KLLL+ A N +E P+ A E
Sbjct: 479 NADPNIQDQEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHE 538
Query: 1077 VVQLFLQQHPNLVMATTKD 1095
V+Q F+ +H L +A +D
Sbjct: 539 VIQ-FMLEHGALSIAAIQD 556
Score = 66.5 bits (155), Expect = 1e-09
Identities = 50/164 (30%), Positives = 78/164 (47%), Gaps = 9/164 (5%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H AA GHV + LL+ VD T +T L A E V++TL+ GA V
Sbjct: 357 GGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARV 416
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + + LH AA + D C + L+++ PN G TP+ AA G + + +
Sbjct: 417 DL-VDQDGHSLLHWAALGGNADVCQI-LIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
L+E+ DP I D G T L +C + D ++ L++F
Sbjct: 475 LMENNADP------NIQD-QEGRTALHWSCNNGYLDAIKLLLDF 511
Score = 64.1 bits (149), Expect = 5e-09
Identities = 40/157 (25%), Positives = 75/157 (47%), Gaps = 1/157 (0%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ + A G+ ++R +LS ++ + G TALH AA V ++L++ A
Sbjct: 322 GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNA 381
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VDAT+ TPL A G + +++ A + D + + +H AA G+A + ++
Sbjct: 382 QVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQI 441
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
L + K + + G T + A+ G+ +C +L +
Sbjct: 442 LIEN-KINPNVQDYAGRTPLQCAAYGGYINCMAVLME 477
Score = 62.1 bits (144), Expect = 2e-08
Identities = 41/129 (31%), Positives = 60/129 (46%), Gaps = 7/129 (5%)
Query: 98 GDTALHLAARRRD---VDMARILVDYGAVVDATNGA---GQTPLHIAAAEGDEPLVKYFY 151
G LH AA +D V R ++D N G+TPLH A A+G+ +V
Sbjct: 182 GKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLT 241
Query: 152 GVRA-NAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
+ N DN RTP+H AA GHA I+ LL ++ K+ G+T +H A+ +
Sbjct: 242 SYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNF 301
Query: 211 ADCAMMLFK 219
A+ + K
Sbjct: 302 AETVKVFLK 310
Score = 54.0 bits (124), Expect = 5e-06
Identities = 57/196 (29%), Positives = 86/196 (43%), Gaps = 21/196 (10%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY--TALHIAVESCKPAVVETLLGYG 719
+G S AA G ++ T+L +D+ D Y TALH A S + V+ LL
Sbjct: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
A V + TPL A + D L+K GA + +DG + +H AA GN
Sbjct: 381 AQVDAT-DVMKHTPLFRACEMGHKD-VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV 438
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF 839
+L+E+ +P V Y G TPLQ A + + L+E + A
Sbjct: 439 CQILIENKINP----NVQDY---AGRTPLQCAAYGGYINCMAVLME----------NNAD 481
Query: 840 IDAVDEDGASALHYAC 855
+ D++G +ALH++C
Sbjct: 482 PNIQDQEGRTALHWSC 497
Score = 54.0 bits (124), Expect = 5e-06
Identities = 36/120 (30%), Positives = 57/120 (47%), Gaps = 2/120 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL A E G++ +++ L+ L G + LH AA + D+ +IL++ +
Sbjct: 393 PLFRACEMGHKDVIQTLIKGGARVDL--VDQDGHSLLHWAALGGNADVCQILIENKINPN 450
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ AG+TPL AA G + A+ I D E RT +H + NG+ I+LL D
Sbjct: 451 VQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDQEGRTALHWSCNNGYLDAIKLLLD 510
Score = 53.6 bits (123), Expect = 7e-06
Identities = 44/163 (26%), Positives = 71/163 (43%), Gaps = 5/163 (3%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G PL A ++ V+ L + + + G T+ AA + D+ R ++
Sbjct: 288 QGATPLHYAAQSNFAETVKVFLKHPSVKD--DSDLEGRTSFMWAAGKGSDDVLRTMLSLK 345
Query: 122 AVVDAT--NGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
+ +D + G T LH AA G VK A D TP+ A E GH +
Sbjct: 346 SDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDV 405
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGV 222
I+ L K A + +DG +L+H A+L G+AD +L + +
Sbjct: 406 IQTLI-KGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKI 447
Score = 52.4 bits (120), Expect = 2e-05
Identities = 40/160 (25%), Positives = 74/160 (46%), Gaps = 4/160 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL A G+ +V LL + + + + G T LH AA+ + ++ + + +V
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ-GATPLHYAAQSNFAETVKVFLKHPSV 314
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI--ADNEDRTPMHLAAENGHAAIIE 181
D ++ G+T AA +G + +++ ++++ I AD T +H AA +GH + ++
Sbjct: 315 KDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVK 374
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LL + A + T + A GH D L K G
Sbjct: 375 LLLEN-NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGG 413
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/157 (26%), Positives = 74/157 (47%), Gaps = 4/157 (2%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQT 133
G++ ++ L+ +A + K G T L +D A L+ GA V+ T+ + +T
Sbjct: 25 GDKGALQRLIVGNSALKDKEDQ-FGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRT 83
Query: 134 PLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKA--SI 191
LH+AA +G+ +K RAN D E+ TP+HL + + LL KF A +
Sbjct: 84 ALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL-KFMAPGEV 142
Query: 192 FERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
+ K+ T +H ++ + + +L K + +P+
Sbjct: 143 DTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPD 179
Score = 49.6 bits (113), Expect = 1e-04
Identities = 38/161 (23%), Positives = 67/161 (41%), Gaps = 6/161 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL L + + LL ++ TALH +A + + ++L+ + + +
Sbjct: 117 PLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIG 176
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIA------DNEDRTPMHLAAENGHAAI 179
+ G+ PLH AA D V + A D E RTP+H A +G+ +
Sbjct: 177 IPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTV 236
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+++L +I T +H A+L GHA +L ++
Sbjct: 237 VDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLER 277
>BC041665-1|AAH41665.1| 604|Homo sapiens Similar to inversin protein.
Length = 604
Score = 165 bits (402), Expect = 1e-39
Identities = 141/512 (27%), Positives = 230/512 (44%), Gaps = 28/512 (5%)
Query: 895 HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
H A+ G+ + +I S ++++ G TPL+ + + LL A
Sbjct: 19 HAAAVNGDKGALQRLIVGNSALK-----DKEDQFGRTPLMYCVLADRLDCADALLKAGAD 73
Query: 955 VDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
V+ D R+ALHLAA+ G + LLT +A K T LHL + + L
Sbjct: 74 VNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALL 133
Query: 1015 IRDHN-AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN- 1072
++ +D KQT LH +A E KLL++ +NI D G+ P+H AA +
Sbjct: 134 LKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHK 193
Query: 1073 --NYSEVVQLFLQQHPNLVMATTKD--GNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
+ V+ L P + +D G T H A G+V V++ L ++ + S N
Sbjct: 194 DPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDN 253
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCT-DENRAGLTAVHLAAEHGHTNVLDVMRST 1187
TPL AA GHA +V +L+ S T + G T +H AA+ + V
Sbjct: 254 LFR--TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+++ S G T AA G + +R +LS +KS+ ++ + G T
Sbjct: 312 PSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLS-----LKSDIDINMA------DKYGGTA 360
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH AA +G+ + V+LLL + Q DA ++ + PL AC GH ++ L+ A +
Sbjct: 361 LHAAALSGHVSTVKLLLEN-NAQVDA-TDVMKHTPLFRACEMGHKDVIQTLIKGGARV-D 417
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
D+ G + LH A+ G+ + ++L+ N D G TPL CAA G++N + +L E
Sbjct: 418 LVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME 477
Query: 1368 SGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+ A P + + ++ + + D ++ LL
Sbjct: 478 NNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 147 bits (355), Expect = 6e-34
Identities = 136/470 (28%), Positives = 209/470 (44%), Gaps = 27/470 (5%)
Query: 944 LVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAA 1003
L ++ N A D D GR+ L L DALL A +N + RTALHLAA
Sbjct: 30 LQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAA 89
Query: 1004 MNGYAHLVKFLI-RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDE 1060
G +K L+ R N M L++ TPLHL + LLL+ A +D D+
Sbjct: 90 QKGNYRFMKLLLTRRANWMQK--DLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDK 147
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQ---GSVKVIEELMK 1117
Q +H +A N E V+L ++ N+ + +G H AA +V + ++
Sbjct: 148 NKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV-EGKIPLHWAANHKDPSAVHTVRCILD 206
Query: 1118 FDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR-AGASCTDENRAGLTAVHLAAEHG 1176
T + TPL A G+ VV VL + T + T +H AA G
Sbjct: 207 AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLG 266
Query: 1177 HTNVLDVMRSTNTL-RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSL 1235
H ++ ++ N I S G TPLH AA AETV+ L H +VK ++
Sbjct: 267 HAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP--SVKDDSDL---- 320
Query: 1236 VPVLGAESGLTPLHLAAYNGNENVVRLLLN-SAGVQADAASNENGYNPLHLACFGGHMSI 1294
G T AA G+++V+R +L+ + + + A G LH A GH+S
Sbjct: 321 -------EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGG-TALHAAALSGHVST 372
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
V LLL +A++ +TD T L A GH +++ L+ GA ++ D++G + LH AA
Sbjct: 373 VKLLLENNAQV-DATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAA 431
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G+ +V ++L E+ +P + P+ AA + + + L+ D
Sbjct: 432 LGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNAD 481
Score = 130 bits (315), Expect = 4e-29
Identities = 141/521 (27%), Positives = 234/521 (44%), Gaps = 38/521 (7%)
Query: 703 AVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATE 762
AV K A+ ++G A + + + TPL + D CA LLK+GA NK
Sbjct: 22 AVNGDKGALQRLIVGNSA-LKDKEDQFGRTPLMYCV-LADRLDCADALLKAGADVNKTDH 79
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
T +H+AA+ GN + LLL + ++K + TPL + R P +
Sbjct: 80 SQRTALHLAAQKGNYRFMKLLLTRRANWMQKD-------LEEMTPLHLTTRHRSPKCLAL 132
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L++F+ GE +D D++ +ALH++ E VK LI++ +++
Sbjct: 133 LLKFMA--PGE------VDTQDKNKQTALHWSAYYNNPE---------HVKLLIKHDSNI 175
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ + H+ A + + + + A LN Q+ G TPL A G++
Sbjct: 176 GIPDVEG-KIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNV 234
Query: 943 QLVNTLLT-NHARVDVFDVEGRSALHLAAEHGYLQVCDALL-TNKAFINSKARNGRTALH 1000
+V+ L + + +D R+ LH AA G+ Q+ LL NK+ G T LH
Sbjct: 235 TVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLH 294
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID--AT 1058
AA + +A VK ++ H ++ D L+ +T AA G +V + +L L ++ID
Sbjct: 295 YAAQSNFAETVKVFLK-HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMA 353
Query: 1059 DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKF 1118
D+ G +HAAA + + V+L L+ + V AT +T A G VI+ L+K
Sbjct: 354 DKYGGTALHAAALSGHVSTVKLLLENNAQ-VDATDVMKHTPLFRACEMGHKDVIQTLIKG 412
Query: 1119 D-RTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGH 1177
R ++ + + L AA GG+ADV ++L+ + ++ AG T + AA G+
Sbjct: 413 GARVDLVDQ----DGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 468
Query: 1178 TNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
N + V+ N K G T LH + G + ++ LL
Sbjct: 469 INCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 127 bits (307), Expect = 4e-28
Identities = 123/451 (27%), Positives = 201/451 (44%), Gaps = 32/451 (7%)
Query: 964 SALHLAAEHGYLQVCDALLT-NKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
S +H AA +G L+ N A + + + GRT L + L++ A +
Sbjct: 16 SQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKA-GADV 74
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
+ ++T LHLAA G KLLL AN D P+H ++ + + L L
Sbjct: 75 NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL 134
Query: 1083 Q-QHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT-GVISARNKLNDSTPLQLAA 1140
+ P V K+ T H +A + + ++ L+K D G+ K+ PL AA
Sbjct: 135 KFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKI----PLHWAA 190
Query: 1141 ---EGGHADVVRVLVRAGAS---CTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISS 1194
+ VR ++ A + ++ G T +H A G+ V+DV+ S + I+S
Sbjct: 191 NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITS 250
Query: 1195 -KKLGLTPLHIAAYYGQAETVRELLS-HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
L TPLH AA G A+ V LL + GT+ S++ G TPLH AA
Sbjct: 251 YDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS-------------QGATPLHYAA 297
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL-LHSTDR 1311
+ V++ L V+ D S+ G A G ++ +LS +++ ++ D+
Sbjct: 298 QSNFAETVKVFLKHPSVKDD--SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADK 355
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGAS 1371
+G T LH A+ GH V++LL A+++ATD TPL A + GH +V++ L + GA
Sbjct: 356 YGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGAR 415
Query: 1372 PKSETNLNCAPIWFAASENHNDVLEYLLHKE 1402
+ + +AA + DV + L+ +
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENK 446
Score = 122 bits (294), Expect = 1e-26
Identities = 124/479 (25%), Positives = 215/479 (44%), Gaps = 40/479 (8%)
Query: 680 NTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAAR 739
+ LL+ G V+ T + TALH+A + ++ LL A+ ++ + TPLH+ R
Sbjct: 65 DALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRAN-WMQKDLEEMTPLHLTTR 123
Query: 740 IPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVC 797
KC +LLK A T+D T +H +A + N + LL++ + +
Sbjct: 124 -HRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIK------HDSNIG 176
Query: 798 IYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKV 857
I D V G+ PL A P V H + + D + + + ++ D +G + LH+A V
Sbjct: 177 IPD-VEGKIPLHWAANHKDPSAV-HTVRCILD---AAPTESLLNWQDYEGRTPLHFA--V 229
Query: 858 TKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTAD 917
V + C I + ++ T H+ A+ G+ ++ ++ +
Sbjct: 230 ADGNVTVVDVLTSYESCNITSYDNL-------FRTPLHWAALLGHAQIVHLLLERNKSGT 282
Query: 918 VSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQV 977
+ +S G TPL A + V L + + D D+EGR++ AA G V
Sbjct: 283 IP-----SDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDV 337
Query: 978 CDALLTNKA--FINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHL 1035
+L+ K+ IN + G TALH AA++G+ VK L+ ++NA +D + K TPL
Sbjct: 338 LRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL-ENNAQVDATDVMKHTPLFR 396
Query: 1036 AAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKD 1095
A G +V + L++ GA +D D+ G +H AA ++V Q+ ++ N + +D
Sbjct: 397 ACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIE---NKINPNVQD 453
Query: 1096 --GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
G T AA G + + LM+ + I + T L + G+ D +++L+
Sbjct: 454 YAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK---EGRTALHWSCNNGYLDAIKLLL 509
Score = 118 bits (285), Expect = 2e-25
Identities = 117/439 (26%), Positives = 199/439 (45%), Gaps = 43/439 (9%)
Query: 666 SIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVET---LLGYGADV 722
++H +A Y + + L++ ++ + + LH A P+ V T +L
Sbjct: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTE 211
Query: 723 HIRGGKQRE--TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLA 778
+ + E TPLH A + DG+ + +L S N + D + TP+H AA G+
Sbjct: 212 SLLNWQDYEGRTPLHFA--VADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQ 269
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LLLE R I G TPL A +S + V+ + K SV
Sbjct: 270 IVHLLLE------RNKSGTIPSDSQGATPLHYAAQSNFAETVKVFL------KHPSVK-- 315
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
D D +G ++ +A ++V R ++ +++ D+++ ++ TA H A
Sbjct: 316 --DDSDLEGRTSFMWAAGKGSDDVL-----RTMLS--LKSDIDINMADKYGG-TALHAAA 365
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVF 958
++G+ + ++ + + D + + TPL AC GH ++ TL+ ARVD+
Sbjct: 366 LSGHVSTVKLLLENNAQVDATDVMKH------TPLFRACEMGHKDVIQTLIKGGARVDLV 419
Query: 959 DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH 1018
D +G S LH AA G VC L+ NK N + GRT L AA GY + + L+ ++
Sbjct: 420 DQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM-EN 478
Query: 1019 NAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDELGQKPIHAAAQNNYSE 1076
NA ++ + +T LH + +G ++ KLLL+ A N +E P+ A E
Sbjct: 479 NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHE 538
Query: 1077 VVQLFLQQHPNLVMATTKD 1095
V+Q F+ +H L +A +D
Sbjct: 539 VIQ-FMLEHGALSIAAIQD 556
Score = 68.1 bits (159), Expect = 3e-10
Identities = 49/164 (29%), Positives = 78/164 (47%), Gaps = 9/164 (5%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H AA GHV + LL+ VD T +T L A E V++TL+ GA V
Sbjct: 357 GGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARV 416
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + + LH AA + D C + L+++ PN G TP+ AA G + + +
Sbjct: 417 DL-VDQDGHSLLHWAALGGNADVCQI-LIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
L+E+ DP + K G T L +C + D ++ L++F
Sbjct: 475 LMENNADPNIQDK-------EGRTALHWSCNNGYLDAIKLLLDF 511
Score = 64.5 bits (150), Expect = 4e-09
Identities = 41/167 (24%), Positives = 79/167 (47%), Gaps = 1/167 (0%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ + A G+ ++R +LS ++ + G TALH AA V ++L++ A
Sbjct: 322 GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNA 381
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VDAT+ TPL A G + +++ A + D + + +H AA G+A + ++
Sbjct: 382 QVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQI 441
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L + K + + G T + A+ G+ +C +L + ++ +K
Sbjct: 442 LIEN-KINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK 487
Score = 62.1 bits (144), Expect = 2e-08
Identities = 41/129 (31%), Positives = 60/129 (46%), Gaps = 7/129 (5%)
Query: 98 GDTALHLAARRRD---VDMARILVDYGAVVDATNGA---GQTPLHIAAAEGDEPLVKYFY 151
G LH AA +D V R ++D N G+TPLH A A+G+ +V
Sbjct: 182 GKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLT 241
Query: 152 GVRA-NAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
+ N DN RTP+H AA GHA I+ LL ++ K+ G+T +H A+ +
Sbjct: 242 SYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNF 301
Query: 211 ADCAMMLFK 219
A+ + K
Sbjct: 302 AETVKVFLK 310
Score = 56.0 bits (129), Expect = 1e-06
Identities = 46/173 (26%), Positives = 75/173 (43%), Gaps = 3/173 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A +G+ S V+ LL + Q+ AT T L A D+ + L+ GA
Sbjct: 357 GGTALHAAALSGHVSTVKLLL--ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGA 414
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VD + G + LH AA G+ + + + N + D RTP+ AA G+ + +
Sbjct: 415 RVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQT 235
L + A + K+G T +H + NG+ D +L + + E+ T
Sbjct: 475 LMEN-NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYT 526
Score = 53.6 bits (123), Expect = 7e-06
Identities = 57/196 (29%), Positives = 86/196 (43%), Gaps = 21/196 (10%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY--TALHIAVESCKPAVVETLLGYG 719
+G S AA G ++ T+L +D+ D Y TALH A S + V+ LL
Sbjct: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
A V + TPL A + D L+K GA + +DG + +H AA GN
Sbjct: 381 AQVDAT-DVMKHTPLFRACEMGHKD-VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV 438
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF 839
+L+E+ +P V Y G TPLQ A + + L+E + A
Sbjct: 439 CQILIENKINP----NVQDY---AGRTPLQCAAYGGYINCMAVLME----------NNAD 481
Query: 840 IDAVDEDGASALHYAC 855
+ D++G +ALH++C
Sbjct: 482 PNIQDKEGRTALHWSC 497
Score = 52.4 bits (120), Expect = 2e-05
Identities = 40/160 (25%), Positives = 74/160 (46%), Gaps = 4/160 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL A G+ +V LL + + + + G T LH AA+ + ++ + + +V
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ-GATPLHYAAQSNFAETVKVFLKHPSV 314
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI--ADNEDRTPMHLAAENGHAAIIE 181
D ++ G+T AA +G + +++ ++++ I AD T +H AA +GH + ++
Sbjct: 315 KDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVK 374
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LL + A + T + A GH D L K G
Sbjct: 375 LLLEN-NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGG 413
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/157 (26%), Positives = 74/157 (47%), Gaps = 4/157 (2%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQT 133
G++ ++ L+ +A + K G T L +D A L+ GA V+ T+ + +T
Sbjct: 25 GDKGALQRLIVGNSALKDKEDQ-FGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRT 83
Query: 134 PLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKA--SI 191
LH+AA +G+ +K RAN D E+ TP+HL + + LL KF A +
Sbjct: 84 ALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL-KFMAPGEV 142
Query: 192 FERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
+ K+ T +H ++ + + +L K + +P+
Sbjct: 143 DTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPD 179
Score = 49.6 bits (113), Expect = 1e-04
Identities = 38/161 (23%), Positives = 67/161 (41%), Gaps = 6/161 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL L + + LL ++ TALH +A + + ++L+ + + +
Sbjct: 117 PLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIG 176
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIA------DNEDRTPMHLAAENGHAAI 179
+ G+ PLH AA D V + A D E RTP+H A +G+ +
Sbjct: 177 IPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTV 236
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+++L +I T +H A+L GHA +L ++
Sbjct: 237 VDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLER 277
>AL445214-4|CAI39744.1| 1065|Homo sapiens inversin protein.
Length = 1065
Score = 165 bits (402), Expect = 1e-39
Identities = 141/512 (27%), Positives = 230/512 (44%), Gaps = 28/512 (5%)
Query: 895 HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
H A+ G+ + +I S ++++ G TPL+ + + LL A
Sbjct: 19 HAAAVNGDKGALQRLIVGNSALK-----DKEDQFGRTPLMYCVLADRLDCADALLKAGAD 73
Query: 955 VDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
V+ D R+ALHLAA+ G + LLT +A K T LHL + + L
Sbjct: 74 VNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALL 133
Query: 1015 IRDHN-AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN- 1072
++ +D KQT LH +A E KLL++ +NI D G+ P+H AA +
Sbjct: 134 LKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHK 193
Query: 1073 --NYSEVVQLFLQQHPNLVMATTKD--GNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
+ V+ L P + +D G T H A G+V V++ L ++ + S N
Sbjct: 194 DPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDN 253
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCT-DENRAGLTAVHLAAEHGHTNVLDVMRST 1187
TPL AA GHA +V +L+ S T + G T +H AA+ + V
Sbjct: 254 LFR--TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+++ S G T AA G + +R +LS +KS+ ++ + G T
Sbjct: 312 PSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLS-----LKSDIDINMA------DKYGGTA 360
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH AA +G+ + V+LLL + Q DA ++ + PL AC GH ++ L+ A +
Sbjct: 361 LHAAALSGHVSTVKLLLEN-NAQVDA-TDVMKHTPLFRACEMGHKDVIQTLIKGGARV-D 417
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
D+ G + LH A+ G+ + ++L+ N D G TPL CAA G++N + +L E
Sbjct: 418 LVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME 477
Query: 1368 SGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+ A P + + ++ + + D ++ LL
Sbjct: 478 NNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 147 bits (355), Expect = 6e-34
Identities = 136/470 (28%), Positives = 209/470 (44%), Gaps = 27/470 (5%)
Query: 944 LVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAA 1003
L ++ N A D D GR+ L L DALL A +N + RTALHLAA
Sbjct: 30 LQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAA 89
Query: 1004 MNGYAHLVKFLI-RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDE 1060
G +K L+ R N M L++ TPLHL + LLL+ A +D D+
Sbjct: 90 QKGNYRFMKLLLTRRANWMQK--DLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDK 147
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQ---GSVKVIEELMK 1117
Q +H +A N E V+L ++ N+ + +G H AA +V + ++
Sbjct: 148 NKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV-EGKIPLHWAANHKDPSAVHTVRCILD 206
Query: 1118 FDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR-AGASCTDENRAGLTAVHLAAEHG 1176
T + TPL A G+ VV VL + T + T +H AA G
Sbjct: 207 AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLG 266
Query: 1177 HTNVLDVMRSTNTL-RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSL 1235
H ++ ++ N I S G TPLH AA AETV+ L H +VK ++
Sbjct: 267 HAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP--SVKDDSDL---- 320
Query: 1236 VPVLGAESGLTPLHLAAYNGNENVVRLLLN-SAGVQADAASNENGYNPLHLACFGGHMSI 1294
G T AA G+++V+R +L+ + + + A G LH A GH+S
Sbjct: 321 -------EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGG-TALHAAALSGHVST 372
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
V LLL +A++ +TD T L A GH +++ L+ GA ++ D++G + LH AA
Sbjct: 373 VKLLLENNAQV-DATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAA 431
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G+ +V ++L E+ +P + P+ AA + + + L+ D
Sbjct: 432 LGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNAD 481
Score = 130 bits (315), Expect = 4e-29
Identities = 141/521 (27%), Positives = 234/521 (44%), Gaps = 38/521 (7%)
Query: 703 AVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATE 762
AV K A+ ++G A + + + TPL + D CA LLK+GA NK
Sbjct: 22 AVNGDKGALQRLIVGNSA-LKDKEDQFGRTPLMYCV-LADRLDCADALLKAGADVNKTDH 79
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
T +H+AA+ GN + LLL + ++K + TPL + R P +
Sbjct: 80 SQRTALHLAAQKGNYRFMKLLLTRRANWMQKD-------LEEMTPLHLTTRHRSPKCLAL 132
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L++F+ GE +D D++ +ALH++ E VK LI++ +++
Sbjct: 133 LLKFMA--PGE------VDTQDKNKQTALHWSAYYNNPE---------HVKLLIKHDSNI 175
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ + H+ A + + + + A LN Q+ G TPL A G++
Sbjct: 176 GIPDVEG-KIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNV 234
Query: 943 QLVNTLLT-NHARVDVFDVEGRSALHLAAEHGYLQVCDALL-TNKAFINSKARNGRTALH 1000
+V+ L + + +D R+ LH AA G+ Q+ LL NK+ G T LH
Sbjct: 235 TVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLH 294
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID--AT 1058
AA + +A VK ++ H ++ D L+ +T AA G +V + +L L ++ID
Sbjct: 295 YAAQSNFAETVKVFLK-HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMA 353
Query: 1059 DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKF 1118
D+ G +HAAA + + V+L L+ + V AT +T A G VI+ L+K
Sbjct: 354 DKYGGTALHAAALSGHVSTVKLLLENNAQ-VDATDVMKHTPLFRACEMGHKDVIQTLIKG 412
Query: 1119 D-RTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGH 1177
R ++ + + L AA GG+ADV ++L+ + ++ AG T + AA G+
Sbjct: 413 GARVDLVDQ----DGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 468
Query: 1178 TNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
N + V+ N K G T LH + G + ++ LL
Sbjct: 469 INCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 127 bits (307), Expect = 4e-28
Identities = 123/451 (27%), Positives = 201/451 (44%), Gaps = 32/451 (7%)
Query: 964 SALHLAAEHGYLQVCDALLT-NKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
S +H AA +G L+ N A + + + GRT L + L++ A +
Sbjct: 16 SQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKA-GADV 74
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
+ ++T LHLAA G KLLL AN D P+H ++ + + L L
Sbjct: 75 NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL 134
Query: 1083 Q-QHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT-GVISARNKLNDSTPLQLAA 1140
+ P V K+ T H +A + + ++ L+K D G+ K+ PL AA
Sbjct: 135 KFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKI----PLHWAA 190
Query: 1141 ---EGGHADVVRVLVRAGAS---CTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISS 1194
+ VR ++ A + ++ G T +H A G+ V+DV+ S + I+S
Sbjct: 191 NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITS 250
Query: 1195 -KKLGLTPLHIAAYYGQAETVRELLS-HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
L TPLH AA G A+ V LL + GT+ S++ G TPLH AA
Sbjct: 251 YDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS-------------QGATPLHYAA 297
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL-LHSTDR 1311
+ V++ L V+ D S+ G A G ++ +LS +++ ++ D+
Sbjct: 298 QSNFAETVKVFLKHPSVKDD--SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADK 355
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGAS 1371
+G T LH A+ GH V++LL A+++ATD TPL A + GH +V++ L + GA
Sbjct: 356 YGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGAR 415
Query: 1372 PKSETNLNCAPIWFAASENHNDVLEYLLHKE 1402
+ + +AA + DV + L+ +
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENK 446
Score = 122 bits (294), Expect = 1e-26
Identities = 124/479 (25%), Positives = 215/479 (44%), Gaps = 40/479 (8%)
Query: 680 NTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAAR 739
+ LL+ G V+ T + TALH+A + ++ LL A+ ++ + TPLH+ R
Sbjct: 65 DALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRAN-WMQKDLEEMTPLHLTTR 123
Query: 740 IPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVC 797
KC +LLK A T+D T +H +A + N + LL++ + +
Sbjct: 124 -HRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIK------HDSNIG 176
Query: 798 IYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKV 857
I D V G+ PL A P V H + + D + + + ++ D +G + LH+A V
Sbjct: 177 IPD-VEGKIPLHWAANHKDPSAV-HTVRCILD---AAPTESLLNWQDYEGRTPLHFA--V 229
Query: 858 TKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTAD 917
V + C I + ++ T H+ A+ G+ ++ ++ +
Sbjct: 230 ADGNVTVVDVLTSYESCNITSYDNL-------FRTPLHWAALLGHAQIVHLLLERNKSGT 282
Query: 918 VSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQV 977
+ +S G TPL A + V L + + D D+EGR++ AA G V
Sbjct: 283 IP-----SDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDV 337
Query: 978 CDALLTNKA--FINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHL 1035
+L+ K+ IN + G TALH AA++G+ VK L+ ++NA +D + K TPL
Sbjct: 338 LRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL-ENNAQVDATDVMKHTPLFR 396
Query: 1036 AAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKD 1095
A G +V + L++ GA +D D+ G +H AA ++V Q+ ++ N + +D
Sbjct: 397 ACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIE---NKINPNVQD 453
Query: 1096 --GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
G T AA G + + LM+ + I + T L + G+ D +++L+
Sbjct: 454 YAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK---EGRTALHWSCNNGYLDAIKLLL 509
Score = 118 bits (285), Expect = 2e-25
Identities = 117/439 (26%), Positives = 199/439 (45%), Gaps = 43/439 (9%)
Query: 666 SIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVET---LLGYGADV 722
++H +A Y + + L++ ++ + + LH A P+ V T +L
Sbjct: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTE 211
Query: 723 HIRGGKQRE--TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLA 778
+ + E TPLH A + DG+ + +L S N + D + TP+H AA G+
Sbjct: 212 SLLNWQDYEGRTPLHFA--VADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQ 269
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LLLE R I G TPL A +S + V+ + K SV
Sbjct: 270 IVHLLLE------RNKSGTIPSDSQGATPLHYAAQSNFAETVKVFL------KHPSVK-- 315
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
D D +G ++ +A ++V R ++ +++ D+++ ++ TA H A
Sbjct: 316 --DDSDLEGRTSFMWAAGKGSDDVL-----RTMLS--LKSDIDINMADKYGG-TALHAAA 365
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVF 958
++G+ + ++ + + D + + TPL AC GH ++ TL+ ARVD+
Sbjct: 366 LSGHVSTVKLLLENNAQVDATDVMKH------TPLFRACEMGHKDVIQTLIKGGARVDLV 419
Query: 959 DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH 1018
D +G S LH AA G VC L+ NK N + GRT L AA GY + + L+ ++
Sbjct: 420 DQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM-EN 478
Query: 1019 NAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDELGQKPIHAAAQNNYSE 1076
NA ++ + +T LH + +G ++ KLLL+ A N +E P+ A E
Sbjct: 479 NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHE 538
Query: 1077 VVQLFLQQHPNLVMATTKD 1095
V+Q F+ +H L +A +D
Sbjct: 539 VIQ-FMLEHGALSIAAIQD 556
Score = 68.1 bits (159), Expect = 3e-10
Identities = 49/164 (29%), Positives = 78/164 (47%), Gaps = 9/164 (5%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H AA GHV + LL+ VD T +T L A E V++TL+ GA V
Sbjct: 357 GGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARV 416
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + + LH AA + D C + L+++ PN G TP+ AA G + + +
Sbjct: 417 DL-VDQDGHSLLHWAALGGNADVCQI-LIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
L+E+ DP + K G T L +C + D ++ L++F
Sbjct: 475 LMENNADPNIQDK-------EGRTALHWSCNNGYLDAIKLLLDF 511
Score = 64.5 bits (150), Expect = 4e-09
Identities = 41/167 (24%), Positives = 79/167 (47%), Gaps = 1/167 (0%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ + A G+ ++R +LS ++ + G TALH AA V ++L++ A
Sbjct: 322 GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNA 381
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VDAT+ TPL A G + +++ A + D + + +H AA G+A + ++
Sbjct: 382 QVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQI 441
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L + K + + G T + A+ G+ +C +L + ++ +K
Sbjct: 442 LIEN-KINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK 487
Score = 62.1 bits (144), Expect = 2e-08
Identities = 41/129 (31%), Positives = 60/129 (46%), Gaps = 7/129 (5%)
Query: 98 GDTALHLAARRRD---VDMARILVDYGAVVDATNGA---GQTPLHIAAAEGDEPLVKYFY 151
G LH AA +D V R ++D N G+TPLH A A+G+ +V
Sbjct: 182 GKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLT 241
Query: 152 GVRA-NAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
+ N DN RTP+H AA GHA I+ LL ++ K+ G+T +H A+ +
Sbjct: 242 SYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNF 301
Query: 211 ADCAMMLFK 219
A+ + K
Sbjct: 302 AETVKVFLK 310
Score = 56.0 bits (129), Expect = 1e-06
Identities = 46/173 (26%), Positives = 75/173 (43%), Gaps = 3/173 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A +G+ S V+ LL + Q+ AT T L A D+ + L+ GA
Sbjct: 357 GGTALHAAALSGHVSTVKLLL--ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGA 414
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VD + G + LH AA G+ + + + N + D RTP+ AA G+ + +
Sbjct: 415 RVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQT 235
L + A + K+G T +H + NG+ D +L + + E+ T
Sbjct: 475 LMEN-NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYT 526
Score = 53.6 bits (123), Expect = 7e-06
Identities = 57/196 (29%), Positives = 86/196 (43%), Gaps = 21/196 (10%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY--TALHIAVESCKPAVVETLLGYG 719
+G S AA G ++ T+L +D+ D Y TALH A S + V+ LL
Sbjct: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
A V + TPL A + D L+K GA + +DG + +H AA GN
Sbjct: 381 AQVDAT-DVMKHTPLFRACEMGHKD-VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV 438
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF 839
+L+E+ +P V Y G TPLQ A + + L+E + A
Sbjct: 439 CQILIENKINP----NVQDY---AGRTPLQCAAYGGYINCMAVLME----------NNAD 481
Query: 840 IDAVDEDGASALHYAC 855
+ D++G +ALH++C
Sbjct: 482 PNIQDKEGRTALHWSC 497
Score = 52.4 bits (120), Expect = 2e-05
Identities = 40/160 (25%), Positives = 74/160 (46%), Gaps = 4/160 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL A G+ +V LL + + + + G T LH AA+ + ++ + + +V
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ-GATPLHYAAQSNFAETVKVFLKHPSV 314
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI--ADNEDRTPMHLAAENGHAAIIE 181
D ++ G+T AA +G + +++ ++++ I AD T +H AA +GH + ++
Sbjct: 315 KDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVK 374
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LL + A + T + A GH D L K G
Sbjct: 375 LLLEN-NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGG 413
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/157 (26%), Positives = 74/157 (47%), Gaps = 4/157 (2%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQT 133
G++ ++ L+ +A + K G T L +D A L+ GA V+ T+ + +T
Sbjct: 25 GDKGALQRLIVGNSALKDKEDQ-FGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRT 83
Query: 134 PLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKA--SI 191
LH+AA +G+ +K RAN D E+ TP+HL + + LL KF A +
Sbjct: 84 ALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL-KFMAPGEV 142
Query: 192 FERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
+ K+ T +H ++ + + +L K + +P+
Sbjct: 143 DTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPD 179
Score = 49.6 bits (113), Expect = 1e-04
Identities = 38/161 (23%), Positives = 67/161 (41%), Gaps = 6/161 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL L + + LL ++ TALH +A + + ++L+ + + +
Sbjct: 117 PLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIG 176
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIA------DNEDRTPMHLAAENGHAAI 179
+ G+ PLH AA D V + A D E RTP+H A +G+ +
Sbjct: 177 IPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTV 236
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+++L +I T +H A+L GHA +L ++
Sbjct: 237 VDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLER 277
>AL445214-3|CAI39745.2| 895|Homo sapiens inversin protein.
Length = 895
Score = 165 bits (402), Expect = 1e-39
Identities = 141/512 (27%), Positives = 230/512 (44%), Gaps = 28/512 (5%)
Query: 895 HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
H A+ G+ + +I S ++++ G TPL+ + + LL A
Sbjct: 19 HAAAVNGDKGALQRLIVGNSALK-----DKEDQFGRTPLMYCVLADRLDCADALLKAGAD 73
Query: 955 VDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
V+ D R+ALHLAA+ G + LLT +A K T LHL + + L
Sbjct: 74 VNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALL 133
Query: 1015 IRDHN-AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN- 1072
++ +D KQT LH +A E KLL++ +NI D G+ P+H AA +
Sbjct: 134 LKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHK 193
Query: 1073 --NYSEVVQLFLQQHPNLVMATTKD--GNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
+ V+ L P + +D G T H A G+V V++ L ++ + S N
Sbjct: 194 DPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDN 253
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCT-DENRAGLTAVHLAAEHGHTNVLDVMRST 1187
TPL AA GHA +V +L+ S T + G T +H AA+ + V
Sbjct: 254 LFR--TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+++ S G T AA G + +R +LS +KS+ ++ + G T
Sbjct: 312 PSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLS-----LKSDIDINMA------DKYGGTA 360
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH AA +G+ + V+LLL + Q DA ++ + PL AC GH ++ L+ A +
Sbjct: 361 LHAAALSGHVSTVKLLLEN-NAQVDA-TDVMKHTPLFRACEMGHKDVIQTLIKGGARV-D 417
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
D+ G + LH A+ G+ + ++L+ N D G TPL CAA G++N + +L E
Sbjct: 418 LVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME 477
Query: 1368 SGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+ A P + + ++ + + D ++ LL
Sbjct: 478 NNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 147 bits (355), Expect = 6e-34
Identities = 136/470 (28%), Positives = 209/470 (44%), Gaps = 27/470 (5%)
Query: 944 LVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAA 1003
L ++ N A D D GR+ L L DALL A +N + RTALHLAA
Sbjct: 30 LQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAA 89
Query: 1004 MNGYAHLVKFLI-RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDE 1060
G +K L+ R N M L++ TPLHL + LLL+ A +D D+
Sbjct: 90 QKGNYRFMKLLLTRRANWMQK--DLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDK 147
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQ---GSVKVIEELMK 1117
Q +H +A N E V+L ++ N+ + +G H AA +V + ++
Sbjct: 148 NKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV-EGKIPLHWAANHKDPSAVHTVRCILD 206
Query: 1118 FDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR-AGASCTDENRAGLTAVHLAAEHG 1176
T + TPL A G+ VV VL + T + T +H AA G
Sbjct: 207 AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLG 266
Query: 1177 HTNVLDVMRSTNTL-RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSL 1235
H ++ ++ N I S G TPLH AA AETV+ L H +VK ++
Sbjct: 267 HAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP--SVKDDSDL---- 320
Query: 1236 VPVLGAESGLTPLHLAAYNGNENVVRLLLN-SAGVQADAASNENGYNPLHLACFGGHMSI 1294
G T AA G+++V+R +L+ + + + A G LH A GH+S
Sbjct: 321 -------EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGG-TALHAAALSGHVST 372
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
V LLL +A++ +TD T L A GH +++ L+ GA ++ D++G + LH AA
Sbjct: 373 VKLLLENNAQV-DATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAA 431
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G+ +V ++L E+ +P + P+ AA + + + L+ D
Sbjct: 432 LGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNAD 481
Score = 130 bits (315), Expect = 4e-29
Identities = 141/521 (27%), Positives = 234/521 (44%), Gaps = 38/521 (7%)
Query: 703 AVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATE 762
AV K A+ ++G A + + + TPL + D CA LLK+GA NK
Sbjct: 22 AVNGDKGALQRLIVGNSA-LKDKEDQFGRTPLMYCV-LADRLDCADALLKAGADVNKTDH 79
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
T +H+AA+ GN + LLL + ++K + TPL + R P +
Sbjct: 80 SQRTALHLAAQKGNYRFMKLLLTRRANWMQKD-------LEEMTPLHLTTRHRSPKCLAL 132
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L++F+ GE +D D++ +ALH++ E VK LI++ +++
Sbjct: 133 LLKFMA--PGE------VDTQDKNKQTALHWSAYYNNPE---------HVKLLIKHDSNI 175
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ + H+ A + + + + A LN Q+ G TPL A G++
Sbjct: 176 GIPDVEG-KIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNV 234
Query: 943 QLVNTLLT-NHARVDVFDVEGRSALHLAAEHGYLQVCDALL-TNKAFINSKARNGRTALH 1000
+V+ L + + +D R+ LH AA G+ Q+ LL NK+ G T LH
Sbjct: 235 TVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLH 294
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID--AT 1058
AA + +A VK ++ H ++ D L+ +T AA G +V + +L L ++ID
Sbjct: 295 YAAQSNFAETVKVFLK-HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMA 353
Query: 1059 DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKF 1118
D+ G +HAAA + + V+L L+ + V AT +T A G VI+ L+K
Sbjct: 354 DKYGGTALHAAALSGHVSTVKLLLENNAQ-VDATDVMKHTPLFRACEMGHKDVIQTLIKG 412
Query: 1119 D-RTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGH 1177
R ++ + + L AA GG+ADV ++L+ + ++ AG T + AA G+
Sbjct: 413 GARVDLVDQ----DGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 468
Query: 1178 TNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
N + V+ N K G T LH + G + ++ LL
Sbjct: 469 INCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 127 bits (307), Expect = 4e-28
Identities = 123/451 (27%), Positives = 201/451 (44%), Gaps = 32/451 (7%)
Query: 964 SALHLAAEHGYLQVCDALLT-NKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
S +H AA +G L+ N A + + + GRT L + L++ A +
Sbjct: 16 SQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKA-GADV 74
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
+ ++T LHLAA G KLLL AN D P+H ++ + + L L
Sbjct: 75 NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL 134
Query: 1083 Q-QHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT-GVISARNKLNDSTPLQLAA 1140
+ P V K+ T H +A + + ++ L+K D G+ K+ PL AA
Sbjct: 135 KFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKI----PLHWAA 190
Query: 1141 ---EGGHADVVRVLVRAGAS---CTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISS 1194
+ VR ++ A + ++ G T +H A G+ V+DV+ S + I+S
Sbjct: 191 NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITS 250
Query: 1195 -KKLGLTPLHIAAYYGQAETVRELLS-HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
L TPLH AA G A+ V LL + GT+ S++ G TPLH AA
Sbjct: 251 YDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS-------------QGATPLHYAA 297
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL-LHSTDR 1311
+ V++ L V+ D S+ G A G ++ +LS +++ ++ D+
Sbjct: 298 QSNFAETVKVFLKHPSVKDD--SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADK 355
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGAS 1371
+G T LH A+ GH V++LL A+++ATD TPL A + GH +V++ L + GA
Sbjct: 356 YGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGAR 415
Query: 1372 PKSETNLNCAPIWFAASENHNDVLEYLLHKE 1402
+ + +AA + DV + L+ +
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENK 446
Score = 122 bits (294), Expect = 1e-26
Identities = 124/479 (25%), Positives = 215/479 (44%), Gaps = 40/479 (8%)
Query: 680 NTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAAR 739
+ LL+ G V+ T + TALH+A + ++ LL A+ ++ + TPLH+ R
Sbjct: 65 DALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRAN-WMQKDLEEMTPLHLTTR 123
Query: 740 IPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVC 797
KC +LLK A T+D T +H +A + N + LL++ + +
Sbjct: 124 -HRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIK------HDSNIG 176
Query: 798 IYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKV 857
I D V G+ PL A P V H + + D + + + ++ D +G + LH+A V
Sbjct: 177 IPD-VEGKIPLHWAANHKDPSAV-HTVRCILD---AAPTESLLNWQDYEGRTPLHFA--V 229
Query: 858 TKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTAD 917
V + C I + ++ T H+ A+ G+ ++ ++ +
Sbjct: 230 ADGNVTVVDVLTSYESCNITSYDNL-------FRTPLHWAALLGHAQIVHLLLERNKSGT 282
Query: 918 VSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQV 977
+ +S G TPL A + V L + + D D+EGR++ AA G V
Sbjct: 283 IP-----SDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDV 337
Query: 978 CDALLTNKA--FINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHL 1035
+L+ K+ IN + G TALH AA++G+ VK L+ ++NA +D + K TPL
Sbjct: 338 LRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL-ENNAQVDATDVMKHTPLFR 396
Query: 1036 AAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKD 1095
A G +V + L++ GA +D D+ G +H AA ++V Q+ ++ N + +D
Sbjct: 397 ACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIE---NKINPNVQD 453
Query: 1096 --GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
G T AA G + + LM+ + I + T L + G+ D +++L+
Sbjct: 454 YAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK---EGRTALHWSCNNGYLDAIKLLL 509
Score = 118 bits (285), Expect = 2e-25
Identities = 117/439 (26%), Positives = 199/439 (45%), Gaps = 43/439 (9%)
Query: 666 SIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVET---LLGYGADV 722
++H +A Y + + L++ ++ + + LH A P+ V T +L
Sbjct: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTE 211
Query: 723 HIRGGKQRE--TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLA 778
+ + E TPLH A + DG+ + +L S N + D + TP+H AA G+
Sbjct: 212 SLLNWQDYEGRTPLHFA--VADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQ 269
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LLLE R I G TPL A +S + V+ + K SV
Sbjct: 270 IVHLLLE------RNKSGTIPSDSQGATPLHYAAQSNFAETVKVFL------KHPSVK-- 315
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
D D +G ++ +A ++V R ++ +++ D+++ ++ TA H A
Sbjct: 316 --DDSDLEGRTSFMWAAGKGSDDVL-----RTMLS--LKSDIDINMADKYGG-TALHAAA 365
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVF 958
++G+ + ++ + + D + + TPL AC GH ++ TL+ ARVD+
Sbjct: 366 LSGHVSTVKLLLENNAQVDATDVMKH------TPLFRACEMGHKDVIQTLIKGGARVDLV 419
Query: 959 DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH 1018
D +G S LH AA G VC L+ NK N + GRT L AA GY + + L+ ++
Sbjct: 420 DQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM-EN 478
Query: 1019 NAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDELGQKPIHAAAQNNYSE 1076
NA ++ + +T LH + +G ++ KLLL+ A N +E P+ A E
Sbjct: 479 NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHE 538
Query: 1077 VVQLFLQQHPNLVMATTKD 1095
V+Q F+ +H L +A +D
Sbjct: 539 VIQ-FMLEHGALSIAAIQD 556
Score = 68.1 bits (159), Expect = 3e-10
Identities = 49/164 (29%), Positives = 78/164 (47%), Gaps = 9/164 (5%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H AA GHV + LL+ VD T +T L A E V++TL+ GA V
Sbjct: 357 GGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARV 416
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + + LH AA + D C + L+++ PN G TP+ AA G + + +
Sbjct: 417 DL-VDQDGHSLLHWAALGGNADVCQI-LIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
L+E+ DP + K G T L +C + D ++ L++F
Sbjct: 475 LMENNADPNIQDK-------EGRTALHWSCNNGYLDAIKLLLDF 511
Score = 64.5 bits (150), Expect = 4e-09
Identities = 41/167 (24%), Positives = 79/167 (47%), Gaps = 1/167 (0%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ + A G+ ++R +LS ++ + G TALH AA V ++L++ A
Sbjct: 322 GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNA 381
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VDAT+ TPL A G + +++ A + D + + +H AA G+A + ++
Sbjct: 382 QVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQI 441
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L + K + + G T + A+ G+ +C +L + ++ +K
Sbjct: 442 LIEN-KINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK 487
Score = 62.1 bits (144), Expect = 2e-08
Identities = 41/129 (31%), Positives = 60/129 (46%), Gaps = 7/129 (5%)
Query: 98 GDTALHLAARRRD---VDMARILVDYGAVVDATNGA---GQTPLHIAAAEGDEPLVKYFY 151
G LH AA +D V R ++D N G+TPLH A A+G+ +V
Sbjct: 182 GKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLT 241
Query: 152 GVRA-NAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
+ N DN RTP+H AA GHA I+ LL ++ K+ G+T +H A+ +
Sbjct: 242 SYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNF 301
Query: 211 ADCAMMLFK 219
A+ + K
Sbjct: 302 AETVKVFLK 310
Score = 56.0 bits (129), Expect = 1e-06
Identities = 46/173 (26%), Positives = 75/173 (43%), Gaps = 3/173 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A +G+ S V+ LL + Q+ AT T L A D+ + L+ GA
Sbjct: 357 GGTALHAAALSGHVSTVKLLL--ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGA 414
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VD + G + LH AA G+ + + + N + D RTP+ AA G+ + +
Sbjct: 415 RVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQT 235
L + A + K+G T +H + NG+ D +L + + E+ T
Sbjct: 475 LMEN-NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYT 526
Score = 53.6 bits (123), Expect = 7e-06
Identities = 57/196 (29%), Positives = 86/196 (43%), Gaps = 21/196 (10%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY--TALHIAVESCKPAVVETLLGYG 719
+G S AA G ++ T+L +D+ D Y TALH A S + V+ LL
Sbjct: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
A V + TPL A + D L+K GA + +DG + +H AA GN
Sbjct: 381 AQVDAT-DVMKHTPLFRACEMGHKD-VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV 438
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF 839
+L+E+ +P V Y G TPLQ A + + L+E + A
Sbjct: 439 CQILIENKINP----NVQDY---AGRTPLQCAAYGGYINCMAVLME----------NNAD 481
Query: 840 IDAVDEDGASALHYAC 855
+ D++G +ALH++C
Sbjct: 482 PNIQDKEGRTALHWSC 497
Score = 52.4 bits (120), Expect = 2e-05
Identities = 40/160 (25%), Positives = 74/160 (46%), Gaps = 4/160 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL A G+ +V LL + + + + G T LH AA+ + ++ + + +V
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ-GATPLHYAAQSNFAETVKVFLKHPSV 314
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI--ADNEDRTPMHLAAENGHAAIIE 181
D ++ G+T AA +G + +++ ++++ I AD T +H AA +GH + ++
Sbjct: 315 KDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVK 374
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LL + A + T + A GH D L K G
Sbjct: 375 LLLEN-NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGG 413
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/157 (26%), Positives = 74/157 (47%), Gaps = 4/157 (2%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQT 133
G++ ++ L+ +A + K G T L +D A L+ GA V+ T+ + +T
Sbjct: 25 GDKGALQRLIVGNSALKDKEDQ-FGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRT 83
Query: 134 PLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKA--SI 191
LH+AA +G+ +K RAN D E+ TP+HL + + LL KF A +
Sbjct: 84 ALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL-KFMAPGEV 142
Query: 192 FERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
+ K+ T +H ++ + + +L K + +P+
Sbjct: 143 DTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPD 179
Score = 49.6 bits (113), Expect = 1e-04
Identities = 38/161 (23%), Positives = 67/161 (41%), Gaps = 6/161 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL L + + LL ++ TALH +A + + ++L+ + + +
Sbjct: 117 PLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIG 176
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIA------DNEDRTPMHLAAENGHAAI 179
+ G+ PLH AA D V + A D E RTP+H A +G+ +
Sbjct: 177 IPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTV 236
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+++L +I T +H A+L GHA +L ++
Sbjct: 237 VDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLER 277
>AL356798-2|CAI40807.1| 1065|Homo sapiens inversin protein.
Length = 1065
Score = 165 bits (402), Expect = 1e-39
Identities = 141/512 (27%), Positives = 230/512 (44%), Gaps = 28/512 (5%)
Query: 895 HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
H A+ G+ + +I S ++++ G TPL+ + + LL A
Sbjct: 19 HAAAVNGDKGALQRLIVGNSALK-----DKEDQFGRTPLMYCVLADRLDCADALLKAGAD 73
Query: 955 VDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
V+ D R+ALHLAA+ G + LLT +A K T LHL + + L
Sbjct: 74 VNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALL 133
Query: 1015 IRDHN-AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN- 1072
++ +D KQT LH +A E KLL++ +NI D G+ P+H AA +
Sbjct: 134 LKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHK 193
Query: 1073 --NYSEVVQLFLQQHPNLVMATTKD--GNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
+ V+ L P + +D G T H A G+V V++ L ++ + S N
Sbjct: 194 DPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDN 253
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCT-DENRAGLTAVHLAAEHGHTNVLDVMRST 1187
TPL AA GHA +V +L+ S T + G T +H AA+ + V
Sbjct: 254 LFR--TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+++ S G T AA G + +R +LS +KS+ ++ + G T
Sbjct: 312 PSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLS-----LKSDIDINMA------DKYGGTA 360
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH AA +G+ + V+LLL + Q DA ++ + PL AC GH ++ L+ A +
Sbjct: 361 LHAAALSGHVSTVKLLLEN-NAQVDA-TDVMKHTPLFRACEMGHKDVIQTLIKGGARV-D 417
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
D+ G + LH A+ G+ + ++L+ N D G TPL CAA G++N + +L E
Sbjct: 418 LVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME 477
Query: 1368 SGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+ A P + + ++ + + D ++ LL
Sbjct: 478 NNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 147 bits (355), Expect = 6e-34
Identities = 136/470 (28%), Positives = 209/470 (44%), Gaps = 27/470 (5%)
Query: 944 LVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAA 1003
L ++ N A D D GR+ L L DALL A +N + RTALHLAA
Sbjct: 30 LQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAA 89
Query: 1004 MNGYAHLVKFLI-RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDE 1060
G +K L+ R N M L++ TPLHL + LLL+ A +D D+
Sbjct: 90 QKGNYRFMKLLLTRRANWMQK--DLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDK 147
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQ---GSVKVIEELMK 1117
Q +H +A N E V+L ++ N+ + +G H AA +V + ++
Sbjct: 148 NKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV-EGKIPLHWAANHKDPSAVHTVRCILD 206
Query: 1118 FDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR-AGASCTDENRAGLTAVHLAAEHG 1176
T + TPL A G+ VV VL + T + T +H AA G
Sbjct: 207 AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLG 266
Query: 1177 HTNVLDVMRSTNTL-RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSL 1235
H ++ ++ N I S G TPLH AA AETV+ L H +VK ++
Sbjct: 267 HAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP--SVKDDSDL---- 320
Query: 1236 VPVLGAESGLTPLHLAAYNGNENVVRLLLN-SAGVQADAASNENGYNPLHLACFGGHMSI 1294
G T AA G+++V+R +L+ + + + A G LH A GH+S
Sbjct: 321 -------EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGG-TALHAAALSGHVST 372
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
V LLL +A++ +TD T L A GH +++ L+ GA ++ D++G + LH AA
Sbjct: 373 VKLLLENNAQV-DATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAA 431
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G+ +V ++L E+ +P + P+ AA + + + L+ D
Sbjct: 432 LGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNAD 481
Score = 130 bits (315), Expect = 4e-29
Identities = 141/521 (27%), Positives = 234/521 (44%), Gaps = 38/521 (7%)
Query: 703 AVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATE 762
AV K A+ ++G A + + + TPL + D CA LLK+GA NK
Sbjct: 22 AVNGDKGALQRLIVGNSA-LKDKEDQFGRTPLMYCV-LADRLDCADALLKAGADVNKTDH 79
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
T +H+AA+ GN + LLL + ++K + TPL + R P +
Sbjct: 80 SQRTALHLAAQKGNYRFMKLLLTRRANWMQKD-------LEEMTPLHLTTRHRSPKCLAL 132
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L++F+ GE +D D++ +ALH++ E VK LI++ +++
Sbjct: 133 LLKFMA--PGE------VDTQDKNKQTALHWSAYYNNPE---------HVKLLIKHDSNI 175
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ + H+ A + + + + A LN Q+ G TPL A G++
Sbjct: 176 GIPDVEG-KIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNV 234
Query: 943 QLVNTLLT-NHARVDVFDVEGRSALHLAAEHGYLQVCDALL-TNKAFINSKARNGRTALH 1000
+V+ L + + +D R+ LH AA G+ Q+ LL NK+ G T LH
Sbjct: 235 TVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLH 294
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID--AT 1058
AA + +A VK ++ H ++ D L+ +T AA G +V + +L L ++ID
Sbjct: 295 YAAQSNFAETVKVFLK-HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMA 353
Query: 1059 DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKF 1118
D+ G +HAAA + + V+L L+ + V AT +T A G VI+ L+K
Sbjct: 354 DKYGGTALHAAALSGHVSTVKLLLENNAQ-VDATDVMKHTPLFRACEMGHKDVIQTLIKG 412
Query: 1119 D-RTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGH 1177
R ++ + + L AA GG+ADV ++L+ + ++ AG T + AA G+
Sbjct: 413 GARVDLVDQ----DGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 468
Query: 1178 TNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
N + V+ N K G T LH + G + ++ LL
Sbjct: 469 INCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 127 bits (307), Expect = 4e-28
Identities = 123/451 (27%), Positives = 201/451 (44%), Gaps = 32/451 (7%)
Query: 964 SALHLAAEHGYLQVCDALLT-NKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
S +H AA +G L+ N A + + + GRT L + L++ A +
Sbjct: 16 SQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKA-GADV 74
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
+ ++T LHLAA G KLLL AN D P+H ++ + + L L
Sbjct: 75 NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL 134
Query: 1083 Q-QHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT-GVISARNKLNDSTPLQLAA 1140
+ P V K+ T H +A + + ++ L+K D G+ K+ PL AA
Sbjct: 135 KFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKI----PLHWAA 190
Query: 1141 ---EGGHADVVRVLVRAGAS---CTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISS 1194
+ VR ++ A + ++ G T +H A G+ V+DV+ S + I+S
Sbjct: 191 NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITS 250
Query: 1195 -KKLGLTPLHIAAYYGQAETVRELLS-HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
L TPLH AA G A+ V LL + GT+ S++ G TPLH AA
Sbjct: 251 YDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS-------------QGATPLHYAA 297
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL-LHSTDR 1311
+ V++ L V+ D S+ G A G ++ +LS +++ ++ D+
Sbjct: 298 QSNFAETVKVFLKHPSVKDD--SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADK 355
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGAS 1371
+G T LH A+ GH V++LL A+++ATD TPL A + GH +V++ L + GA
Sbjct: 356 YGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGAR 415
Query: 1372 PKSETNLNCAPIWFAASENHNDVLEYLLHKE 1402
+ + +AA + DV + L+ +
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENK 446
Score = 122 bits (294), Expect = 1e-26
Identities = 124/479 (25%), Positives = 215/479 (44%), Gaps = 40/479 (8%)
Query: 680 NTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAAR 739
+ LL+ G V+ T + TALH+A + ++ LL A+ ++ + TPLH+ R
Sbjct: 65 DALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRAN-WMQKDLEEMTPLHLTTR 123
Query: 740 IPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVC 797
KC +LLK A T+D T +H +A + N + LL++ + +
Sbjct: 124 -HRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIK------HDSNIG 176
Query: 798 IYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKV 857
I D V G+ PL A P V H + + D + + + ++ D +G + LH+A V
Sbjct: 177 IPD-VEGKIPLHWAANHKDPSAV-HTVRCILD---AAPTESLLNWQDYEGRTPLHFA--V 229
Query: 858 TKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTAD 917
V + C I + ++ T H+ A+ G+ ++ ++ +
Sbjct: 230 ADGNVTVVDVLTSYESCNITSYDNL-------FRTPLHWAALLGHAQIVHLLLERNKSGT 282
Query: 918 VSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQV 977
+ +S G TPL A + V L + + D D+EGR++ AA G V
Sbjct: 283 IP-----SDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDV 337
Query: 978 CDALLTNKA--FINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHL 1035
+L+ K+ IN + G TALH AA++G+ VK L+ ++NA +D + K TPL
Sbjct: 338 LRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL-ENNAQVDATDVMKHTPLFR 396
Query: 1036 AAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKD 1095
A G +V + L++ GA +D D+ G +H AA ++V Q+ ++ N + +D
Sbjct: 397 ACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIE---NKINPNVQD 453
Query: 1096 --GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
G T AA G + + LM+ + I + T L + G+ D +++L+
Sbjct: 454 YAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK---EGRTALHWSCNNGYLDAIKLLL 509
Score = 118 bits (285), Expect = 2e-25
Identities = 117/439 (26%), Positives = 199/439 (45%), Gaps = 43/439 (9%)
Query: 666 SIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVET---LLGYGADV 722
++H +A Y + + L++ ++ + + LH A P+ V T +L
Sbjct: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTE 211
Query: 723 HIRGGKQRE--TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLA 778
+ + E TPLH A + DG+ + +L S N + D + TP+H AA G+
Sbjct: 212 SLLNWQDYEGRTPLHFA--VADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQ 269
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LLLE R I G TPL A +S + V+ + K SV
Sbjct: 270 IVHLLLE------RNKSGTIPSDSQGATPLHYAAQSNFAETVKVFL------KHPSVK-- 315
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
D D +G ++ +A ++V R ++ +++ D+++ ++ TA H A
Sbjct: 316 --DDSDLEGRTSFMWAAGKGSDDVL-----RTMLS--LKSDIDINMADKYGG-TALHAAA 365
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVF 958
++G+ + ++ + + D + + TPL AC GH ++ TL+ ARVD+
Sbjct: 366 LSGHVSTVKLLLENNAQVDATDVMKH------TPLFRACEMGHKDVIQTLIKGGARVDLV 419
Query: 959 DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH 1018
D +G S LH AA G VC L+ NK N + GRT L AA GY + + L+ ++
Sbjct: 420 DQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM-EN 478
Query: 1019 NAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDELGQKPIHAAAQNNYSE 1076
NA ++ + +T LH + +G ++ KLLL+ A N +E P+ A E
Sbjct: 479 NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHE 538
Query: 1077 VVQLFLQQHPNLVMATTKD 1095
V+Q F+ +H L +A +D
Sbjct: 539 VIQ-FMLEHGALSIAAIQD 556
Score = 68.1 bits (159), Expect = 3e-10
Identities = 49/164 (29%), Positives = 78/164 (47%), Gaps = 9/164 (5%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H AA GHV + LL+ VD T +T L A E V++TL+ GA V
Sbjct: 357 GGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARV 416
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + + LH AA + D C + L+++ PN G TP+ AA G + + +
Sbjct: 417 DL-VDQDGHSLLHWAALGGNADVCQI-LIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
L+E+ DP + K G T L +C + D ++ L++F
Sbjct: 475 LMENNADPNIQDK-------EGRTALHWSCNNGYLDAIKLLLDF 511
Score = 64.5 bits (150), Expect = 4e-09
Identities = 41/167 (24%), Positives = 79/167 (47%), Gaps = 1/167 (0%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ + A G+ ++R +LS ++ + G TALH AA V ++L++ A
Sbjct: 322 GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNA 381
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VDAT+ TPL A G + +++ A + D + + +H AA G+A + ++
Sbjct: 382 QVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQI 441
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L + K + + G T + A+ G+ +C +L + ++ +K
Sbjct: 442 LIEN-KINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK 487
Score = 62.1 bits (144), Expect = 2e-08
Identities = 41/129 (31%), Positives = 60/129 (46%), Gaps = 7/129 (5%)
Query: 98 GDTALHLAARRRD---VDMARILVDYGAVVDATNGA---GQTPLHIAAAEGDEPLVKYFY 151
G LH AA +D V R ++D N G+TPLH A A+G+ +V
Sbjct: 182 GKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLT 241
Query: 152 GVRA-NAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
+ N DN RTP+H AA GHA I+ LL ++ K+ G+T +H A+ +
Sbjct: 242 SYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNF 301
Query: 211 ADCAMMLFK 219
A+ + K
Sbjct: 302 AETVKVFLK 310
Score = 56.0 bits (129), Expect = 1e-06
Identities = 46/173 (26%), Positives = 75/173 (43%), Gaps = 3/173 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A +G+ S V+ LL + Q+ AT T L A D+ + L+ GA
Sbjct: 357 GGTALHAAALSGHVSTVKLLL--ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGA 414
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VD + G + LH AA G+ + + + N + D RTP+ AA G+ + +
Sbjct: 415 RVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQT 235
L + A + K+G T +H + NG+ D +L + + E+ T
Sbjct: 475 LMEN-NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYT 526
Score = 53.6 bits (123), Expect = 7e-06
Identities = 57/196 (29%), Positives = 86/196 (43%), Gaps = 21/196 (10%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY--TALHIAVESCKPAVVETLLGYG 719
+G S AA G ++ T+L +D+ D Y TALH A S + V+ LL
Sbjct: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
A V + TPL A + D L+K GA + +DG + +H AA GN
Sbjct: 381 AQVDAT-DVMKHTPLFRACEMGHKD-VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV 438
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF 839
+L+E+ +P V Y G TPLQ A + + L+E + A
Sbjct: 439 CQILIENKINP----NVQDY---AGRTPLQCAAYGGYINCMAVLME----------NNAD 481
Query: 840 IDAVDEDGASALHYAC 855
+ D++G +ALH++C
Sbjct: 482 PNIQDKEGRTALHWSC 497
Score = 52.4 bits (120), Expect = 2e-05
Identities = 40/160 (25%), Positives = 74/160 (46%), Gaps = 4/160 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL A G+ +V LL + + + + G T LH AA+ + ++ + + +V
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ-GATPLHYAAQSNFAETVKVFLKHPSV 314
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI--ADNEDRTPMHLAAENGHAAIIE 181
D ++ G+T AA +G + +++ ++++ I AD T +H AA +GH + ++
Sbjct: 315 KDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVK 374
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LL + A + T + A GH D L K G
Sbjct: 375 LLLEN-NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGG 413
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/157 (26%), Positives = 74/157 (47%), Gaps = 4/157 (2%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQT 133
G++ ++ L+ +A + K G T L +D A L+ GA V+ T+ + +T
Sbjct: 25 GDKGALQRLIVGNSALKDKEDQ-FGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRT 83
Query: 134 PLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKA--SI 191
LH+AA +G+ +K RAN D E+ TP+HL + + LL KF A +
Sbjct: 84 ALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL-KFMAPGEV 142
Query: 192 FERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
+ K+ T +H ++ + + +L K + +P+
Sbjct: 143 DTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPD 179
Score = 49.6 bits (113), Expect = 1e-04
Identities = 38/161 (23%), Positives = 67/161 (41%), Gaps = 6/161 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL L + + LL ++ TALH +A + + ++L+ + + +
Sbjct: 117 PLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIG 176
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIA------DNEDRTPMHLAAENGHAAI 179
+ G+ PLH AA D V + A D E RTP+H A +G+ +
Sbjct: 177 IPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTV 236
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+++L +I T +H A+L GHA +L ++
Sbjct: 237 VDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLER 277
>AL356798-1|CAI40808.2| 895|Homo sapiens inversin protein.
Length = 895
Score = 165 bits (402), Expect = 1e-39
Identities = 141/512 (27%), Positives = 230/512 (44%), Gaps = 28/512 (5%)
Query: 895 HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
H A+ G+ + +I S ++++ G TPL+ + + LL A
Sbjct: 19 HAAAVNGDKGALQRLIVGNSALK-----DKEDQFGRTPLMYCVLADRLDCADALLKAGAD 73
Query: 955 VDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
V+ D R+ALHLAA+ G + LLT +A K T LHL + + L
Sbjct: 74 VNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALL 133
Query: 1015 IRDHN-AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN- 1072
++ +D KQT LH +A E KLL++ +NI D G+ P+H AA +
Sbjct: 134 LKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHK 193
Query: 1073 --NYSEVVQLFLQQHPNLVMATTKD--GNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
+ V+ L P + +D G T H A G+V V++ L ++ + S N
Sbjct: 194 DPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDN 253
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCT-DENRAGLTAVHLAAEHGHTNVLDVMRST 1187
TPL AA GHA +V +L+ S T + G T +H AA+ + V
Sbjct: 254 LFR--TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+++ S G T AA G + +R +LS +KS+ ++ + G T
Sbjct: 312 PSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLS-----LKSDIDINMA------DKYGGTA 360
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH AA +G+ + V+LLL + Q DA ++ + PL AC GH ++ L+ A +
Sbjct: 361 LHAAALSGHVSTVKLLLEN-NAQVDA-TDVMKHTPLFRACEMGHKDVIQTLIKGGARV-D 417
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
D+ G + LH A+ G+ + ++L+ N D G TPL CAA G++N + +L E
Sbjct: 418 LVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME 477
Query: 1368 SGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+ A P + + ++ + + D ++ LL
Sbjct: 478 NNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 147 bits (355), Expect = 6e-34
Identities = 136/470 (28%), Positives = 209/470 (44%), Gaps = 27/470 (5%)
Query: 944 LVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAA 1003
L ++ N A D D GR+ L L DALL A +N + RTALHLAA
Sbjct: 30 LQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAA 89
Query: 1004 MNGYAHLVKFLI-RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDE 1060
G +K L+ R N M L++ TPLHL + LLL+ A +D D+
Sbjct: 90 QKGNYRFMKLLLTRRANWMQK--DLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDK 147
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQ---GSVKVIEELMK 1117
Q +H +A N E V+L ++ N+ + +G H AA +V + ++
Sbjct: 148 NKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV-EGKIPLHWAANHKDPSAVHTVRCILD 206
Query: 1118 FDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR-AGASCTDENRAGLTAVHLAAEHG 1176
T + TPL A G+ VV VL + T + T +H AA G
Sbjct: 207 AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLG 266
Query: 1177 HTNVLDVMRSTNTL-RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSL 1235
H ++ ++ N I S G TPLH AA AETV+ L H +VK ++
Sbjct: 267 HAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP--SVKDDSDL---- 320
Query: 1236 VPVLGAESGLTPLHLAAYNGNENVVRLLLN-SAGVQADAASNENGYNPLHLACFGGHMSI 1294
G T AA G+++V+R +L+ + + + A G LH A GH+S
Sbjct: 321 -------EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGG-TALHAAALSGHVST 372
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
V LLL +A++ +TD T L A GH +++ L+ GA ++ D++G + LH AA
Sbjct: 373 VKLLLENNAQV-DATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAA 431
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G+ +V ++L E+ +P + P+ AA + + + L+ D
Sbjct: 432 LGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNAD 481
Score = 130 bits (315), Expect = 4e-29
Identities = 141/521 (27%), Positives = 234/521 (44%), Gaps = 38/521 (7%)
Query: 703 AVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATE 762
AV K A+ ++G A + + + TPL + D CA LLK+GA NK
Sbjct: 22 AVNGDKGALQRLIVGNSA-LKDKEDQFGRTPLMYCV-LADRLDCADALLKAGADVNKTDH 79
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
T +H+AA+ GN + LLL + ++K + TPL + R P +
Sbjct: 80 SQRTALHLAAQKGNYRFMKLLLTRRANWMQKD-------LEEMTPLHLTTRHRSPKCLAL 132
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L++F+ GE +D D++ +ALH++ E VK LI++ +++
Sbjct: 133 LLKFMA--PGE------VDTQDKNKQTALHWSAYYNNPE---------HVKLLIKHDSNI 175
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ + H+ A + + + + A LN Q+ G TPL A G++
Sbjct: 176 GIPDVEG-KIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNV 234
Query: 943 QLVNTLLT-NHARVDVFDVEGRSALHLAAEHGYLQVCDALL-TNKAFINSKARNGRTALH 1000
+V+ L + + +D R+ LH AA G+ Q+ LL NK+ G T LH
Sbjct: 235 TVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLH 294
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID--AT 1058
AA + +A VK ++ H ++ D L+ +T AA G +V + +L L ++ID
Sbjct: 295 YAAQSNFAETVKVFLK-HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMA 353
Query: 1059 DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKF 1118
D+ G +HAAA + + V+L L+ + V AT +T A G VI+ L+K
Sbjct: 354 DKYGGTALHAAALSGHVSTVKLLLENNAQ-VDATDVMKHTPLFRACEMGHKDVIQTLIKG 412
Query: 1119 D-RTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGH 1177
R ++ + + L AA GG+ADV ++L+ + ++ AG T + AA G+
Sbjct: 413 GARVDLVDQ----DGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 468
Query: 1178 TNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
N + V+ N K G T LH + G + ++ LL
Sbjct: 469 INCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 127 bits (307), Expect = 4e-28
Identities = 123/451 (27%), Positives = 201/451 (44%), Gaps = 32/451 (7%)
Query: 964 SALHLAAEHGYLQVCDALLT-NKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
S +H AA +G L+ N A + + + GRT L + L++ A +
Sbjct: 16 SQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKA-GADV 74
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
+ ++T LHLAA G KLLL AN D P+H ++ + + L L
Sbjct: 75 NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL 134
Query: 1083 Q-QHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT-GVISARNKLNDSTPLQLAA 1140
+ P V K+ T H +A + + ++ L+K D G+ K+ PL AA
Sbjct: 135 KFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKI----PLHWAA 190
Query: 1141 ---EGGHADVVRVLVRAGAS---CTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISS 1194
+ VR ++ A + ++ G T +H A G+ V+DV+ S + I+S
Sbjct: 191 NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITS 250
Query: 1195 -KKLGLTPLHIAAYYGQAETVRELLS-HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
L TPLH AA G A+ V LL + GT+ S++ G TPLH AA
Sbjct: 251 YDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS-------------QGATPLHYAA 297
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL-LHSTDR 1311
+ V++ L V+ D S+ G A G ++ +LS +++ ++ D+
Sbjct: 298 QSNFAETVKVFLKHPSVKDD--SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADK 355
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGAS 1371
+G T LH A+ GH V++LL A+++ATD TPL A + GH +V++ L + GA
Sbjct: 356 YGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGAR 415
Query: 1372 PKSETNLNCAPIWFAASENHNDVLEYLLHKE 1402
+ + +AA + DV + L+ +
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENK 446
Score = 122 bits (294), Expect = 1e-26
Identities = 124/479 (25%), Positives = 215/479 (44%), Gaps = 40/479 (8%)
Query: 680 NTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAAR 739
+ LL+ G V+ T + TALH+A + ++ LL A+ ++ + TPLH+ R
Sbjct: 65 DALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRAN-WMQKDLEEMTPLHLTTR 123
Query: 740 IPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVC 797
KC +LLK A T+D T +H +A + N + LL++ + +
Sbjct: 124 -HRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIK------HDSNIG 176
Query: 798 IYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKV 857
I D V G+ PL A P V H + + D + + + ++ D +G + LH+A V
Sbjct: 177 IPD-VEGKIPLHWAANHKDPSAV-HTVRCILD---AAPTESLLNWQDYEGRTPLHFA--V 229
Query: 858 TKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTAD 917
V + C I + ++ T H+ A+ G+ ++ ++ +
Sbjct: 230 ADGNVTVVDVLTSYESCNITSYDNL-------FRTPLHWAALLGHAQIVHLLLERNKSGT 282
Query: 918 VSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQV 977
+ +S G TPL A + V L + + D D+EGR++ AA G V
Sbjct: 283 IP-----SDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDV 337
Query: 978 CDALLTNKA--FINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHL 1035
+L+ K+ IN + G TALH AA++G+ VK L+ ++NA +D + K TPL
Sbjct: 338 LRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL-ENNAQVDATDVMKHTPLFR 396
Query: 1036 AAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKD 1095
A G +V + L++ GA +D D+ G +H AA ++V Q+ ++ N + +D
Sbjct: 397 ACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIE---NKINPNVQD 453
Query: 1096 --GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
G T AA G + + LM+ + I + T L + G+ D +++L+
Sbjct: 454 YAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK---EGRTALHWSCNNGYLDAIKLLL 509
Score = 118 bits (285), Expect = 2e-25
Identities = 117/439 (26%), Positives = 199/439 (45%), Gaps = 43/439 (9%)
Query: 666 SIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVET---LLGYGADV 722
++H +A Y + + L++ ++ + + LH A P+ V T +L
Sbjct: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTE 211
Query: 723 HIRGGKQRE--TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLA 778
+ + E TPLH A + DG+ + +L S N + D + TP+H AA G+
Sbjct: 212 SLLNWQDYEGRTPLHFA--VADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQ 269
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LLLE R I G TPL A +S + V+ + K SV
Sbjct: 270 IVHLLLE------RNKSGTIPSDSQGATPLHYAAQSNFAETVKVFL------KHPSVK-- 315
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
D D +G ++ +A ++V R ++ +++ D+++ ++ TA H A
Sbjct: 316 --DDSDLEGRTSFMWAAGKGSDDVL-----RTMLS--LKSDIDINMADKYGG-TALHAAA 365
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVF 958
++G+ + ++ + + D + + TPL AC GH ++ TL+ ARVD+
Sbjct: 366 LSGHVSTVKLLLENNAQVDATDVMKH------TPLFRACEMGHKDVIQTLIKGGARVDLV 419
Query: 959 DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH 1018
D +G S LH AA G VC L+ NK N + GRT L AA GY + + L+ ++
Sbjct: 420 DQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM-EN 478
Query: 1019 NAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDELGQKPIHAAAQNNYSE 1076
NA ++ + +T LH + +G ++ KLLL+ A N +E P+ A E
Sbjct: 479 NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHE 538
Query: 1077 VVQLFLQQHPNLVMATTKD 1095
V+Q F+ +H L +A +D
Sbjct: 539 VIQ-FMLEHGALSIAAIQD 556
Score = 68.1 bits (159), Expect = 3e-10
Identities = 49/164 (29%), Positives = 78/164 (47%), Gaps = 9/164 (5%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H AA GHV + LL+ VD T +T L A E V++TL+ GA V
Sbjct: 357 GGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARV 416
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + + LH AA + D C + L+++ PN G TP+ AA G + + +
Sbjct: 417 DL-VDQDGHSLLHWAALGGNADVCQI-LIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
L+E+ DP + K G T L +C + D ++ L++F
Sbjct: 475 LMENNADPNIQDK-------EGRTALHWSCNNGYLDAIKLLLDF 511
Score = 64.5 bits (150), Expect = 4e-09
Identities = 41/167 (24%), Positives = 79/167 (47%), Gaps = 1/167 (0%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ + A G+ ++R +LS ++ + G TALH AA V ++L++ A
Sbjct: 322 GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNA 381
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VDAT+ TPL A G + +++ A + D + + +H AA G+A + ++
Sbjct: 382 QVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQI 441
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L + K + + G T + A+ G+ +C +L + ++ +K
Sbjct: 442 LIEN-KINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK 487
Score = 62.1 bits (144), Expect = 2e-08
Identities = 41/129 (31%), Positives = 60/129 (46%), Gaps = 7/129 (5%)
Query: 98 GDTALHLAARRRD---VDMARILVDYGAVVDATNGA---GQTPLHIAAAEGDEPLVKYFY 151
G LH AA +D V R ++D N G+TPLH A A+G+ +V
Sbjct: 182 GKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLT 241
Query: 152 GVRA-NAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
+ N DN RTP+H AA GHA I+ LL ++ K+ G+T +H A+ +
Sbjct: 242 SYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNF 301
Query: 211 ADCAMMLFK 219
A+ + K
Sbjct: 302 AETVKVFLK 310
Score = 56.0 bits (129), Expect = 1e-06
Identities = 46/173 (26%), Positives = 75/173 (43%), Gaps = 3/173 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A +G+ S V+ LL + Q+ AT T L A D+ + L+ GA
Sbjct: 357 GGTALHAAALSGHVSTVKLLL--ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGA 414
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VD + G + LH AA G+ + + + N + D RTP+ AA G+ + +
Sbjct: 415 RVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQT 235
L + A + K+G T +H + NG+ D +L + + E+ T
Sbjct: 475 LMEN-NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYT 526
Score = 53.6 bits (123), Expect = 7e-06
Identities = 57/196 (29%), Positives = 86/196 (43%), Gaps = 21/196 (10%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY--TALHIAVESCKPAVVETLLGYG 719
+G S AA G ++ T+L +D+ D Y TALH A S + V+ LL
Sbjct: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
A V + TPL A + D L+K GA + +DG + +H AA GN
Sbjct: 381 AQVDAT-DVMKHTPLFRACEMGHKD-VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV 438
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF 839
+L+E+ +P V Y G TPLQ A + + L+E + A
Sbjct: 439 CQILIENKINP----NVQDY---AGRTPLQCAAYGGYINCMAVLME----------NNAD 481
Query: 840 IDAVDEDGASALHYAC 855
+ D++G +ALH++C
Sbjct: 482 PNIQDKEGRTALHWSC 497
Score = 52.4 bits (120), Expect = 2e-05
Identities = 40/160 (25%), Positives = 74/160 (46%), Gaps = 4/160 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL A G+ +V LL + + + + G T LH AA+ + ++ + + +V
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ-GATPLHYAAQSNFAETVKVFLKHPSV 314
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI--ADNEDRTPMHLAAENGHAAIIE 181
D ++ G+T AA +G + +++ ++++ I AD T +H AA +GH + ++
Sbjct: 315 KDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVK 374
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LL + A + T + A GH D L K G
Sbjct: 375 LLLEN-NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGG 413
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/157 (26%), Positives = 74/157 (47%), Gaps = 4/157 (2%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQT 133
G++ ++ L+ +A + K G T L +D A L+ GA V+ T+ + +T
Sbjct: 25 GDKGALQRLIVGNSALKDKEDQ-FGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRT 83
Query: 134 PLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKA--SI 191
LH+AA +G+ +K RAN D E+ TP+HL + + LL KF A +
Sbjct: 84 ALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL-KFMAPGEV 142
Query: 192 FERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
+ K+ T +H ++ + + +L K + +P+
Sbjct: 143 DTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPD 179
Score = 49.6 bits (113), Expect = 1e-04
Identities = 38/161 (23%), Positives = 67/161 (41%), Gaps = 6/161 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL L + + LL ++ TALH +A + + ++L+ + + +
Sbjct: 117 PLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIG 176
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIA------DNEDRTPMHLAAENGHAAI 179
+ G+ PLH AA D V + A D E RTP+H A +G+ +
Sbjct: 177 IPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTV 236
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+++L +I T +H A+L GHA +L ++
Sbjct: 237 VDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLER 277
>AL137072-3|CAH72173.1| 1065|Homo sapiens inversin protein.
Length = 1065
Score = 165 bits (402), Expect = 1e-39
Identities = 141/512 (27%), Positives = 230/512 (44%), Gaps = 28/512 (5%)
Query: 895 HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
H A+ G+ + +I S ++++ G TPL+ + + LL A
Sbjct: 19 HAAAVNGDKGALQRLIVGNSALK-----DKEDQFGRTPLMYCVLADRLDCADALLKAGAD 73
Query: 955 VDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
V+ D R+ALHLAA+ G + LLT +A K T LHL + + L
Sbjct: 74 VNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALL 133
Query: 1015 IRDHN-AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN- 1072
++ +D KQT LH +A E KLL++ +NI D G+ P+H AA +
Sbjct: 134 LKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHK 193
Query: 1073 --NYSEVVQLFLQQHPNLVMATTKD--GNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
+ V+ L P + +D G T H A G+V V++ L ++ + S N
Sbjct: 194 DPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDN 253
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCT-DENRAGLTAVHLAAEHGHTNVLDVMRST 1187
TPL AA GHA +V +L+ S T + G T +H AA+ + V
Sbjct: 254 LFR--TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+++ S G T AA G + +R +LS +KS+ ++ + G T
Sbjct: 312 PSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLS-----LKSDIDINMA------DKYGGTA 360
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH AA +G+ + V+LLL + Q DA ++ + PL AC GH ++ L+ A +
Sbjct: 361 LHAAALSGHVSTVKLLLEN-NAQVDA-TDVMKHTPLFRACEMGHKDVIQTLIKGGARV-D 417
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
D+ G + LH A+ G+ + ++L+ N D G TPL CAA G++N + +L E
Sbjct: 418 LVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME 477
Query: 1368 SGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+ A P + + ++ + + D ++ LL
Sbjct: 478 NNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 147 bits (355), Expect = 6e-34
Identities = 136/470 (28%), Positives = 209/470 (44%), Gaps = 27/470 (5%)
Query: 944 LVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAA 1003
L ++ N A D D GR+ L L DALL A +N + RTALHLAA
Sbjct: 30 LQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAA 89
Query: 1004 MNGYAHLVKFLI-RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDE 1060
G +K L+ R N M L++ TPLHL + LLL+ A +D D+
Sbjct: 90 QKGNYRFMKLLLTRRANWMQK--DLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDK 147
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQ---GSVKVIEELMK 1117
Q +H +A N E V+L ++ N+ + +G H AA +V + ++
Sbjct: 148 NKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV-EGKIPLHWAANHKDPSAVHTVRCILD 206
Query: 1118 FDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR-AGASCTDENRAGLTAVHLAAEHG 1176
T + TPL A G+ VV VL + T + T +H AA G
Sbjct: 207 AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLG 266
Query: 1177 HTNVLDVMRSTNTL-RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSL 1235
H ++ ++ N I S G TPLH AA AETV+ L H +VK ++
Sbjct: 267 HAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP--SVKDDSDL---- 320
Query: 1236 VPVLGAESGLTPLHLAAYNGNENVVRLLLN-SAGVQADAASNENGYNPLHLACFGGHMSI 1294
G T AA G+++V+R +L+ + + + A G LH A GH+S
Sbjct: 321 -------EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGG-TALHAAALSGHVST 372
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
V LLL +A++ +TD T L A GH +++ L+ GA ++ D++G + LH AA
Sbjct: 373 VKLLLENNAQV-DATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAA 431
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G+ +V ++L E+ +P + P+ AA + + + L+ D
Sbjct: 432 LGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNAD 481
Score = 130 bits (315), Expect = 4e-29
Identities = 141/521 (27%), Positives = 234/521 (44%), Gaps = 38/521 (7%)
Query: 703 AVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATE 762
AV K A+ ++G A + + + TPL + D CA LLK+GA NK
Sbjct: 22 AVNGDKGALQRLIVGNSA-LKDKEDQFGRTPLMYCV-LADRLDCADALLKAGADVNKTDH 79
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
T +H+AA+ GN + LLL + ++K + TPL + R P +
Sbjct: 80 SQRTALHLAAQKGNYRFMKLLLTRRANWMQKD-------LEEMTPLHLTTRHRSPKCLAL 132
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L++F+ GE +D D++ +ALH++ E VK LI++ +++
Sbjct: 133 LLKFMA--PGE------VDTQDKNKQTALHWSAYYNNPE---------HVKLLIKHDSNI 175
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ + H+ A + + + + A LN Q+ G TPL A G++
Sbjct: 176 GIPDVEG-KIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNV 234
Query: 943 QLVNTLLT-NHARVDVFDVEGRSALHLAAEHGYLQVCDALL-TNKAFINSKARNGRTALH 1000
+V+ L + + +D R+ LH AA G+ Q+ LL NK+ G T LH
Sbjct: 235 TVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLH 294
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID--AT 1058
AA + +A VK ++ H ++ D L+ +T AA G +V + +L L ++ID
Sbjct: 295 YAAQSNFAETVKVFLK-HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMA 353
Query: 1059 DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKF 1118
D+ G +HAAA + + V+L L+ + V AT +T A G VI+ L+K
Sbjct: 354 DKYGGTALHAAALSGHVSTVKLLLENNAQ-VDATDVMKHTPLFRACEMGHKDVIQTLIKG 412
Query: 1119 D-RTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGH 1177
R ++ + + L AA GG+ADV ++L+ + ++ AG T + AA G+
Sbjct: 413 GARVDLVDQ----DGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 468
Query: 1178 TNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
N + V+ N K G T LH + G + ++ LL
Sbjct: 469 INCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 127 bits (307), Expect = 4e-28
Identities = 123/451 (27%), Positives = 201/451 (44%), Gaps = 32/451 (7%)
Query: 964 SALHLAAEHGYLQVCDALLT-NKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
S +H AA +G L+ N A + + + GRT L + L++ A +
Sbjct: 16 SQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKA-GADV 74
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
+ ++T LHLAA G KLLL AN D P+H ++ + + L L
Sbjct: 75 NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL 134
Query: 1083 Q-QHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT-GVISARNKLNDSTPLQLAA 1140
+ P V K+ T H +A + + ++ L+K D G+ K+ PL AA
Sbjct: 135 KFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKI----PLHWAA 190
Query: 1141 ---EGGHADVVRVLVRAGAS---CTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISS 1194
+ VR ++ A + ++ G T +H A G+ V+DV+ S + I+S
Sbjct: 191 NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITS 250
Query: 1195 -KKLGLTPLHIAAYYGQAETVRELLS-HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
L TPLH AA G A+ V LL + GT+ S++ G TPLH AA
Sbjct: 251 YDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS-------------QGATPLHYAA 297
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL-LHSTDR 1311
+ V++ L V+ D S+ G A G ++ +LS +++ ++ D+
Sbjct: 298 QSNFAETVKVFLKHPSVKDD--SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADK 355
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGAS 1371
+G T LH A+ GH V++LL A+++ATD TPL A + GH +V++ L + GA
Sbjct: 356 YGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGAR 415
Query: 1372 PKSETNLNCAPIWFAASENHNDVLEYLLHKE 1402
+ + +AA + DV + L+ +
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENK 446
Score = 122 bits (294), Expect = 1e-26
Identities = 124/479 (25%), Positives = 215/479 (44%), Gaps = 40/479 (8%)
Query: 680 NTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAAR 739
+ LL+ G V+ T + TALH+A + ++ LL A+ ++ + TPLH+ R
Sbjct: 65 DALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRAN-WMQKDLEEMTPLHLTTR 123
Query: 740 IPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVC 797
KC +LLK A T+D T +H +A + N + LL++ + +
Sbjct: 124 -HRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIK------HDSNIG 176
Query: 798 IYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKV 857
I D V G+ PL A P V H + + D + + + ++ D +G + LH+A V
Sbjct: 177 IPD-VEGKIPLHWAANHKDPSAV-HTVRCILD---AAPTESLLNWQDYEGRTPLHFA--V 229
Query: 858 TKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTAD 917
V + C I + ++ T H+ A+ G+ ++ ++ +
Sbjct: 230 ADGNVTVVDVLTSYESCNITSYDNL-------FRTPLHWAALLGHAQIVHLLLERNKSGT 282
Query: 918 VSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQV 977
+ +S G TPL A + V L + + D D+EGR++ AA G V
Sbjct: 283 IP-----SDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDV 337
Query: 978 CDALLTNKA--FINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHL 1035
+L+ K+ IN + G TALH AA++G+ VK L+ ++NA +D + K TPL
Sbjct: 338 LRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL-ENNAQVDATDVMKHTPLFR 396
Query: 1036 AAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKD 1095
A G +V + L++ GA +D D+ G +H AA ++V Q+ ++ N + +D
Sbjct: 397 ACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIE---NKINPNVQD 453
Query: 1096 --GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
G T AA G + + LM+ + I + T L + G+ D +++L+
Sbjct: 454 YAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK---EGRTALHWSCNNGYLDAIKLLL 509
Score = 118 bits (285), Expect = 2e-25
Identities = 117/439 (26%), Positives = 199/439 (45%), Gaps = 43/439 (9%)
Query: 666 SIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVET---LLGYGADV 722
++H +A Y + + L++ ++ + + LH A P+ V T +L
Sbjct: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTE 211
Query: 723 HIRGGKQRE--TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLA 778
+ + E TPLH A + DG+ + +L S N + D + TP+H AA G+
Sbjct: 212 SLLNWQDYEGRTPLHFA--VADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQ 269
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LLLE R I G TPL A +S + V+ + K SV
Sbjct: 270 IVHLLLE------RNKSGTIPSDSQGATPLHYAAQSNFAETVKVFL------KHPSVK-- 315
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
D D +G ++ +A ++V R ++ +++ D+++ ++ TA H A
Sbjct: 316 --DDSDLEGRTSFMWAAGKGSDDVL-----RTMLS--LKSDIDINMADKYGG-TALHAAA 365
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVF 958
++G+ + ++ + + D + + TPL AC GH ++ TL+ ARVD+
Sbjct: 366 LSGHVSTVKLLLENNAQVDATDVMKH------TPLFRACEMGHKDVIQTLIKGGARVDLV 419
Query: 959 DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH 1018
D +G S LH AA G VC L+ NK N + GRT L AA GY + + L+ ++
Sbjct: 420 DQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM-EN 478
Query: 1019 NAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDELGQKPIHAAAQNNYSE 1076
NA ++ + +T LH + +G ++ KLLL+ A N +E P+ A E
Sbjct: 479 NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHE 538
Query: 1077 VVQLFLQQHPNLVMATTKD 1095
V+Q F+ +H L +A +D
Sbjct: 539 VIQ-FMLEHGALSIAAIQD 556
Score = 68.1 bits (159), Expect = 3e-10
Identities = 49/164 (29%), Positives = 78/164 (47%), Gaps = 9/164 (5%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H AA GHV + LL+ VD T +T L A E V++TL+ GA V
Sbjct: 357 GGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARV 416
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + + LH AA + D C + L+++ PN G TP+ AA G + + +
Sbjct: 417 DL-VDQDGHSLLHWAALGGNADVCQI-LIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
L+E+ DP + K G T L +C + D ++ L++F
Sbjct: 475 LMENNADPNIQDK-------EGRTALHWSCNNGYLDAIKLLLDF 511
Score = 64.5 bits (150), Expect = 4e-09
Identities = 41/167 (24%), Positives = 79/167 (47%), Gaps = 1/167 (0%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ + A G+ ++R +LS ++ + G TALH AA V ++L++ A
Sbjct: 322 GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNA 381
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VDAT+ TPL A G + +++ A + D + + +H AA G+A + ++
Sbjct: 382 QVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQI 441
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L + K + + G T + A+ G+ +C +L + ++ +K
Sbjct: 442 LIEN-KINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK 487
Score = 62.1 bits (144), Expect = 2e-08
Identities = 41/129 (31%), Positives = 60/129 (46%), Gaps = 7/129 (5%)
Query: 98 GDTALHLAARRRD---VDMARILVDYGAVVDATNGA---GQTPLHIAAAEGDEPLVKYFY 151
G LH AA +D V R ++D N G+TPLH A A+G+ +V
Sbjct: 182 GKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLT 241
Query: 152 GVRA-NAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
+ N DN RTP+H AA GHA I+ LL ++ K+ G+T +H A+ +
Sbjct: 242 SYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNF 301
Query: 211 ADCAMMLFK 219
A+ + K
Sbjct: 302 AETVKVFLK 310
Score = 56.0 bits (129), Expect = 1e-06
Identities = 46/173 (26%), Positives = 75/173 (43%), Gaps = 3/173 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A +G+ S V+ LL + Q+ AT T L A D+ + L+ GA
Sbjct: 357 GGTALHAAALSGHVSTVKLLL--ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGA 414
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VD + G + LH AA G+ + + + N + D RTP+ AA G+ + +
Sbjct: 415 RVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQT 235
L + A + K+G T +H + NG+ D +L + + E+ T
Sbjct: 475 LMEN-NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYT 526
Score = 53.6 bits (123), Expect = 7e-06
Identities = 57/196 (29%), Positives = 86/196 (43%), Gaps = 21/196 (10%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY--TALHIAVESCKPAVVETLLGYG 719
+G S AA G ++ T+L +D+ D Y TALH A S + V+ LL
Sbjct: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
A V + TPL A + D L+K GA + +DG + +H AA GN
Sbjct: 381 AQVDAT-DVMKHTPLFRACEMGHKD-VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV 438
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF 839
+L+E+ +P V Y G TPLQ A + + L+E + A
Sbjct: 439 CQILIENKINP----NVQDY---AGRTPLQCAAYGGYINCMAVLME----------NNAD 481
Query: 840 IDAVDEDGASALHYAC 855
+ D++G +ALH++C
Sbjct: 482 PNIQDKEGRTALHWSC 497
Score = 52.4 bits (120), Expect = 2e-05
Identities = 40/160 (25%), Positives = 74/160 (46%), Gaps = 4/160 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL A G+ +V LL + + + + G T LH AA+ + ++ + + +V
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ-GATPLHYAAQSNFAETVKVFLKHPSV 314
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI--ADNEDRTPMHLAAENGHAAIIE 181
D ++ G+T AA +G + +++ ++++ I AD T +H AA +GH + ++
Sbjct: 315 KDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVK 374
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LL + A + T + A GH D L K G
Sbjct: 375 LLLEN-NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGG 413
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/157 (26%), Positives = 74/157 (47%), Gaps = 4/157 (2%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQT 133
G++ ++ L+ +A + K G T L +D A L+ GA V+ T+ + +T
Sbjct: 25 GDKGALQRLIVGNSALKDKEDQ-FGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRT 83
Query: 134 PLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKA--SI 191
LH+AA +G+ +K RAN D E+ TP+HL + + LL KF A +
Sbjct: 84 ALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL-KFMAPGEV 142
Query: 192 FERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
+ K+ T +H ++ + + +L K + +P+
Sbjct: 143 DTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPD 179
Score = 49.6 bits (113), Expect = 1e-04
Identities = 38/161 (23%), Positives = 67/161 (41%), Gaps = 6/161 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL L + + LL ++ TALH +A + + ++L+ + + +
Sbjct: 117 PLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIG 176
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIA------DNEDRTPMHLAAENGHAAI 179
+ G+ PLH AA D V + A D E RTP+H A +G+ +
Sbjct: 177 IPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTV 236
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+++L +I T +H A+L GHA +L ++
Sbjct: 237 VDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLER 277
>AL137072-2|CAM16212.1| 895|Homo sapiens inversin protein.
Length = 895
Score = 165 bits (402), Expect = 1e-39
Identities = 141/512 (27%), Positives = 230/512 (44%), Gaps = 28/512 (5%)
Query: 895 HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
H A+ G+ + +I S ++++ G TPL+ + + LL A
Sbjct: 19 HAAAVNGDKGALQRLIVGNSALK-----DKEDQFGRTPLMYCVLADRLDCADALLKAGAD 73
Query: 955 VDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
V+ D R+ALHLAA+ G + LLT +A K T LHL + + L
Sbjct: 74 VNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALL 133
Query: 1015 IRDHN-AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN- 1072
++ +D KQT LH +A E KLL++ +NI D G+ P+H AA +
Sbjct: 134 LKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHK 193
Query: 1073 --NYSEVVQLFLQQHPNLVMATTKD--GNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
+ V+ L P + +D G T H A G+V V++ L ++ + S N
Sbjct: 194 DPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDN 253
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCT-DENRAGLTAVHLAAEHGHTNVLDVMRST 1187
TPL AA GHA +V +L+ S T + G T +H AA+ + V
Sbjct: 254 LFR--TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+++ S G T AA G + +R +LS +KS+ ++ + G T
Sbjct: 312 PSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLS-----LKSDIDINMA------DKYGGTA 360
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH AA +G+ + V+LLL + Q DA ++ + PL AC GH ++ L+ A +
Sbjct: 361 LHAAALSGHVSTVKLLLEN-NAQVDA-TDVMKHTPLFRACEMGHKDVIQTLIKGGARV-D 417
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
D+ G + LH A+ G+ + ++L+ N D G TPL CAA G++N + +L E
Sbjct: 418 LVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME 477
Query: 1368 SGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+ A P + + ++ + + D ++ LL
Sbjct: 478 NNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 147 bits (355), Expect = 6e-34
Identities = 136/470 (28%), Positives = 209/470 (44%), Gaps = 27/470 (5%)
Query: 944 LVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAA 1003
L ++ N A D D GR+ L L DALL A +N + RTALHLAA
Sbjct: 30 LQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAA 89
Query: 1004 MNGYAHLVKFLI-RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDE 1060
G +K L+ R N M L++ TPLHL + LLL+ A +D D+
Sbjct: 90 QKGNYRFMKLLLTRRANWMQK--DLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDK 147
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQ---GSVKVIEELMK 1117
Q +H +A N E V+L ++ N+ + +G H AA +V + ++
Sbjct: 148 NKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV-EGKIPLHWAANHKDPSAVHTVRCILD 206
Query: 1118 FDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR-AGASCTDENRAGLTAVHLAAEHG 1176
T + TPL A G+ VV VL + T + T +H AA G
Sbjct: 207 AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLG 266
Query: 1177 HTNVLDVMRSTNTL-RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSL 1235
H ++ ++ N I S G TPLH AA AETV+ L H +VK ++
Sbjct: 267 HAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP--SVKDDSDL---- 320
Query: 1236 VPVLGAESGLTPLHLAAYNGNENVVRLLLN-SAGVQADAASNENGYNPLHLACFGGHMSI 1294
G T AA G+++V+R +L+ + + + A G LH A GH+S
Sbjct: 321 -------EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGG-TALHAAALSGHVST 372
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
V LLL +A++ +TD T L A GH +++ L+ GA ++ D++G + LH AA
Sbjct: 373 VKLLLENNAQV-DATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAA 431
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G+ +V ++L E+ +P + P+ AA + + + L+ D
Sbjct: 432 LGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNAD 481
Score = 130 bits (315), Expect = 4e-29
Identities = 141/521 (27%), Positives = 234/521 (44%), Gaps = 38/521 (7%)
Query: 703 AVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATE 762
AV K A+ ++G A + + + TPL + D CA LLK+GA NK
Sbjct: 22 AVNGDKGALQRLIVGNSA-LKDKEDQFGRTPLMYCV-LADRLDCADALLKAGADVNKTDH 79
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
T +H+AA+ GN + LLL + ++K + TPL + R P +
Sbjct: 80 SQRTALHLAAQKGNYRFMKLLLTRRANWMQKD-------LEEMTPLHLTTRHRSPKCLAL 132
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L++F+ GE +D D++ +ALH++ E VK LI++ +++
Sbjct: 133 LLKFMA--PGE------VDTQDKNKQTALHWSAYYNNPE---------HVKLLIKHDSNI 175
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ + H+ A + + + + A LN Q+ G TPL A G++
Sbjct: 176 GIPDVEG-KIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNV 234
Query: 943 QLVNTLLT-NHARVDVFDVEGRSALHLAAEHGYLQVCDALL-TNKAFINSKARNGRTALH 1000
+V+ L + + +D R+ LH AA G+ Q+ LL NK+ G T LH
Sbjct: 235 TVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLH 294
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID--AT 1058
AA + +A VK ++ H ++ D L+ +T AA G +V + +L L ++ID
Sbjct: 295 YAAQSNFAETVKVFLK-HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMA 353
Query: 1059 DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKF 1118
D+ G +HAAA + + V+L L+ + V AT +T A G VI+ L+K
Sbjct: 354 DKYGGTALHAAALSGHVSTVKLLLENNAQ-VDATDVMKHTPLFRACEMGHKDVIQTLIKG 412
Query: 1119 D-RTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGH 1177
R ++ + + L AA GG+ADV ++L+ + ++ AG T + AA G+
Sbjct: 413 GARVDLVDQ----DGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 468
Query: 1178 TNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
N + V+ N K G T LH + G + ++ LL
Sbjct: 469 INCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 127 bits (307), Expect = 4e-28
Identities = 123/451 (27%), Positives = 201/451 (44%), Gaps = 32/451 (7%)
Query: 964 SALHLAAEHGYLQVCDALLT-NKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
S +H AA +G L+ N A + + + GRT L + L++ A +
Sbjct: 16 SQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKA-GADV 74
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
+ ++T LHLAA G KLLL AN D P+H ++ + + L L
Sbjct: 75 NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL 134
Query: 1083 Q-QHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT-GVISARNKLNDSTPLQLAA 1140
+ P V K+ T H +A + + ++ L+K D G+ K+ PL AA
Sbjct: 135 KFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKI----PLHWAA 190
Query: 1141 ---EGGHADVVRVLVRAGAS---CTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISS 1194
+ VR ++ A + ++ G T +H A G+ V+DV+ S + I+S
Sbjct: 191 NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITS 250
Query: 1195 -KKLGLTPLHIAAYYGQAETVRELLS-HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
L TPLH AA G A+ V LL + GT+ S++ G TPLH AA
Sbjct: 251 YDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS-------------QGATPLHYAA 297
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL-LHSTDR 1311
+ V++ L V+ D S+ G A G ++ +LS +++ ++ D+
Sbjct: 298 QSNFAETVKVFLKHPSVKDD--SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADK 355
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGAS 1371
+G T LH A+ GH V++LL A+++ATD TPL A + GH +V++ L + GA
Sbjct: 356 YGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGAR 415
Query: 1372 PKSETNLNCAPIWFAASENHNDVLEYLLHKE 1402
+ + +AA + DV + L+ +
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENK 446
Score = 122 bits (294), Expect = 1e-26
Identities = 124/479 (25%), Positives = 215/479 (44%), Gaps = 40/479 (8%)
Query: 680 NTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAAR 739
+ LL+ G V+ T + TALH+A + ++ LL A+ ++ + TPLH+ R
Sbjct: 65 DALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRAN-WMQKDLEEMTPLHLTTR 123
Query: 740 IPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVC 797
KC +LLK A T+D T +H +A + N + LL++ + +
Sbjct: 124 -HRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIK------HDSNIG 176
Query: 798 IYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKV 857
I D V G+ PL A P V H + + D + + + ++ D +G + LH+A V
Sbjct: 177 IPD-VEGKIPLHWAANHKDPSAV-HTVRCILD---AAPTESLLNWQDYEGRTPLHFA--V 229
Query: 858 TKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTAD 917
V + C I + ++ T H+ A+ G+ ++ ++ +
Sbjct: 230 ADGNVTVVDVLTSYESCNITSYDNL-------FRTPLHWAALLGHAQIVHLLLERNKSGT 282
Query: 918 VSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQV 977
+ +S G TPL A + V L + + D D+EGR++ AA G V
Sbjct: 283 IP-----SDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDV 337
Query: 978 CDALLTNKA--FINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHL 1035
+L+ K+ IN + G TALH AA++G+ VK L+ ++NA +D + K TPL
Sbjct: 338 LRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL-ENNAQVDATDVMKHTPLFR 396
Query: 1036 AAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKD 1095
A G +V + L++ GA +D D+ G +H AA ++V Q+ ++ N + +D
Sbjct: 397 ACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIE---NKINPNVQD 453
Query: 1096 --GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
G T AA G + + LM+ + I + T L + G+ D +++L+
Sbjct: 454 YAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK---EGRTALHWSCNNGYLDAIKLLL 509
Score = 118 bits (285), Expect = 2e-25
Identities = 117/439 (26%), Positives = 199/439 (45%), Gaps = 43/439 (9%)
Query: 666 SIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVET---LLGYGADV 722
++H +A Y + + L++ ++ + + LH A P+ V T +L
Sbjct: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTE 211
Query: 723 HIRGGKQRE--TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLA 778
+ + E TPLH A + DG+ + +L S N + D + TP+H AA G+
Sbjct: 212 SLLNWQDYEGRTPLHFA--VADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQ 269
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LLLE R I G TPL A +S + V+ + K SV
Sbjct: 270 IVHLLLE------RNKSGTIPSDSQGATPLHYAAQSNFAETVKVFL------KHPSVK-- 315
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
D D +G ++ +A ++V R ++ +++ D+++ ++ TA H A
Sbjct: 316 --DDSDLEGRTSFMWAAGKGSDDVL-----RTMLS--LKSDIDINMADKYGG-TALHAAA 365
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVF 958
++G+ + ++ + + D + + TPL AC GH ++ TL+ ARVD+
Sbjct: 366 LSGHVSTVKLLLENNAQVDATDVMKH------TPLFRACEMGHKDVIQTLIKGGARVDLV 419
Query: 959 DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH 1018
D +G S LH AA G VC L+ NK N + GRT L AA GY + + L+ ++
Sbjct: 420 DQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM-EN 478
Query: 1019 NAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDELGQKPIHAAAQNNYSE 1076
NA ++ + +T LH + +G ++ KLLL+ A N +E P+ A E
Sbjct: 479 NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHE 538
Query: 1077 VVQLFLQQHPNLVMATTKD 1095
V+Q F+ +H L +A +D
Sbjct: 539 VIQ-FMLEHGALSIAAIQD 556
Score = 68.1 bits (159), Expect = 3e-10
Identities = 49/164 (29%), Positives = 78/164 (47%), Gaps = 9/164 (5%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H AA GHV + LL+ VD T +T L A E V++TL+ GA V
Sbjct: 357 GGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARV 416
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + + LH AA + D C + L+++ PN G TP+ AA G + + +
Sbjct: 417 DL-VDQDGHSLLHWAALGGNADVCQI-LIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
L+E+ DP + K G T L +C + D ++ L++F
Sbjct: 475 LMENNADPNIQDK-------EGRTALHWSCNNGYLDAIKLLLDF 511
Score = 64.5 bits (150), Expect = 4e-09
Identities = 41/167 (24%), Positives = 79/167 (47%), Gaps = 1/167 (0%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ + A G+ ++R +LS ++ + G TALH AA V ++L++ A
Sbjct: 322 GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNA 381
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VDAT+ TPL A G + +++ A + D + + +H AA G+A + ++
Sbjct: 382 QVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQI 441
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L + K + + G T + A+ G+ +C +L + ++ +K
Sbjct: 442 LIEN-KINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK 487
Score = 62.1 bits (144), Expect = 2e-08
Identities = 41/129 (31%), Positives = 60/129 (46%), Gaps = 7/129 (5%)
Query: 98 GDTALHLAARRRD---VDMARILVDYGAVVDATNGA---GQTPLHIAAAEGDEPLVKYFY 151
G LH AA +D V R ++D N G+TPLH A A+G+ +V
Sbjct: 182 GKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLT 241
Query: 152 GVRA-NAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
+ N DN RTP+H AA GHA I+ LL ++ K+ G+T +H A+ +
Sbjct: 242 SYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNF 301
Query: 211 ADCAMMLFK 219
A+ + K
Sbjct: 302 AETVKVFLK 310
Score = 56.0 bits (129), Expect = 1e-06
Identities = 46/173 (26%), Positives = 75/173 (43%), Gaps = 3/173 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A +G+ S V+ LL + Q+ AT T L A D+ + L+ GA
Sbjct: 357 GGTALHAAALSGHVSTVKLLL--ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGA 414
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VD + G + LH AA G+ + + + N + D RTP+ AA G+ + +
Sbjct: 415 RVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQT 235
L + A + K+G T +H + NG+ D +L + + E+ T
Sbjct: 475 LMEN-NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYT 526
Score = 53.6 bits (123), Expect = 7e-06
Identities = 57/196 (29%), Positives = 86/196 (43%), Gaps = 21/196 (10%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY--TALHIAVESCKPAVVETLLGYG 719
+G S AA G ++ T+L +D+ D Y TALH A S + V+ LL
Sbjct: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
A V + TPL A + D L+K GA + +DG + +H AA GN
Sbjct: 381 AQVDAT-DVMKHTPLFRACEMGHKD-VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV 438
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF 839
+L+E+ +P V Y G TPLQ A + + L+E + A
Sbjct: 439 CQILIENKINP----NVQDY---AGRTPLQCAAYGGYINCMAVLME----------NNAD 481
Query: 840 IDAVDEDGASALHYAC 855
+ D++G +ALH++C
Sbjct: 482 PNIQDKEGRTALHWSC 497
Score = 52.4 bits (120), Expect = 2e-05
Identities = 40/160 (25%), Positives = 74/160 (46%), Gaps = 4/160 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL A G+ +V LL + + + + G T LH AA+ + ++ + + +V
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ-GATPLHYAAQSNFAETVKVFLKHPSV 314
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI--ADNEDRTPMHLAAENGHAAIIE 181
D ++ G+T AA +G + +++ ++++ I AD T +H AA +GH + ++
Sbjct: 315 KDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVK 374
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LL + A + T + A GH D L K G
Sbjct: 375 LLLEN-NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGG 413
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/157 (26%), Positives = 74/157 (47%), Gaps = 4/157 (2%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQT 133
G++ ++ L+ +A + K G T L +D A L+ GA V+ T+ + +T
Sbjct: 25 GDKGALQRLIVGNSALKDKEDQ-FGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRT 83
Query: 134 PLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKA--SI 191
LH+AA +G+ +K RAN D E+ TP+HL + + LL KF A +
Sbjct: 84 ALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL-KFMAPGEV 142
Query: 192 FERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
+ K+ T +H ++ + + +L K + +P+
Sbjct: 143 DTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPD 179
Score = 49.6 bits (113), Expect = 1e-04
Identities = 38/161 (23%), Positives = 67/161 (41%), Gaps = 6/161 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL L + + LL ++ TALH +A + + ++L+ + + +
Sbjct: 117 PLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIG 176
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIA------DNEDRTPMHLAAENGHAAI 179
+ G+ PLH AA D V + A D E RTP+H A +G+ +
Sbjct: 177 IPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTV 236
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+++L +I T +H A+L GHA +L ++
Sbjct: 237 VDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLER 277
>AF084382-2|AAC79457.1| 895|Homo sapiens inversin protein alternative
isoform protein.
Length = 895
Score = 165 bits (402), Expect = 1e-39
Identities = 141/512 (27%), Positives = 230/512 (44%), Gaps = 28/512 (5%)
Query: 895 HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
H A+ G+ + +I S ++++ G TPL+ + + LL A
Sbjct: 19 HAAAVNGDKGALQRLIVGNSALK-----DKEDQFGRTPLMYCVLADRLDCADALLKAGAD 73
Query: 955 VDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
V+ D R+ALHLAA+ G + LLT +A K T LHL + + L
Sbjct: 74 VNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALL 133
Query: 1015 IRDHN-AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN- 1072
++ +D KQT LH +A E KLL++ +NI D G+ P+H AA +
Sbjct: 134 LKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHK 193
Query: 1073 --NYSEVVQLFLQQHPNLVMATTKD--GNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
+ V+ L P + +D G T H A G+V V++ L ++ + S N
Sbjct: 194 DPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDN 253
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCT-DENRAGLTAVHLAAEHGHTNVLDVMRST 1187
TPL AA GHA +V +L+ S T + G T +H AA+ + V
Sbjct: 254 LFR--TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+++ S G T AA G + +R +LS +KS+ ++ + G T
Sbjct: 312 PSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLS-----LKSDIDINMA------DKYGGTA 360
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH AA +G+ + V+LLL + Q DA ++ + PL AC GH ++ L+ A +
Sbjct: 361 LHAAALSGHVSTVKLLLEN-NAQVDA-TDVMKHTPLFRACEMGHKDVIQTLIKGGARV-D 417
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
D+ G + LH A+ G+ + ++L+ N D G TPL CAA G++N + +L E
Sbjct: 418 LVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME 477
Query: 1368 SGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+ A P + + ++ + + D ++ LL
Sbjct: 478 NNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 147 bits (355), Expect = 6e-34
Identities = 136/470 (28%), Positives = 209/470 (44%), Gaps = 27/470 (5%)
Query: 944 LVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAA 1003
L ++ N A D D GR+ L L DALL A +N + RTALHLAA
Sbjct: 30 LQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAA 89
Query: 1004 MNGYAHLVKFLI-RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDE 1060
G +K L+ R N M L++ TPLHL + LLL+ A +D D+
Sbjct: 90 QKGNYRFMKLLLTRRANWMQK--DLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDK 147
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQ---GSVKVIEELMK 1117
Q +H +A N E V+L ++ N+ + +G H AA +V + ++
Sbjct: 148 NKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV-EGKIPLHWAANHKDPSAVHTVRCILD 206
Query: 1118 FDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR-AGASCTDENRAGLTAVHLAAEHG 1176
T + TPL A G+ VV VL + T + T +H AA G
Sbjct: 207 AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLG 266
Query: 1177 HTNVLDVMRSTNTL-RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSL 1235
H ++ ++ N I S G TPLH AA AETV+ L H +VK ++
Sbjct: 267 HAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP--SVKDDSDL---- 320
Query: 1236 VPVLGAESGLTPLHLAAYNGNENVVRLLLN-SAGVQADAASNENGYNPLHLACFGGHMSI 1294
G T AA G+++V+R +L+ + + + A G LH A GH+S
Sbjct: 321 -------EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGG-TALHAAALSGHVST 372
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
V LLL +A++ +TD T L A GH +++ L+ GA ++ D++G + LH AA
Sbjct: 373 VKLLLENNAQV-DATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAA 431
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G+ +V ++L E+ +P + P+ AA + + + L+ D
Sbjct: 432 LGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNAD 481
Score = 130 bits (315), Expect = 4e-29
Identities = 141/521 (27%), Positives = 234/521 (44%), Gaps = 38/521 (7%)
Query: 703 AVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATE 762
AV K A+ ++G A + + + TPL + D CA LLK+GA NK
Sbjct: 22 AVNGDKGALQRLIVGNSA-LKDKEDQFGRTPLMYCV-LADRLDCADALLKAGADVNKTDH 79
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
T +H+AA+ GN + LLL + ++K + TPL + R P +
Sbjct: 80 SQRTALHLAAQKGNYRFMKLLLTRRANWMQKD-------LEEMTPLHLTTRHRSPKCLAL 132
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L++F+ GE +D D++ +ALH++ E VK LI++ +++
Sbjct: 133 LLKFMA--PGE------VDTQDKNKQTALHWSAYYNNPE---------HVKLLIKHDSNI 175
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ + H+ A + + + + A LN Q+ G TPL A G++
Sbjct: 176 GIPDVEG-KIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNV 234
Query: 943 QLVNTLLT-NHARVDVFDVEGRSALHLAAEHGYLQVCDALL-TNKAFINSKARNGRTALH 1000
+V+ L + + +D R+ LH AA G+ Q+ LL NK+ G T LH
Sbjct: 235 TVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLH 294
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID--AT 1058
AA + +A VK ++ H ++ D L+ +T AA G +V + +L L ++ID
Sbjct: 295 YAAQSNFAETVKVFLK-HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMA 353
Query: 1059 DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKF 1118
D+ G +HAAA + + V+L L+ + V AT +T A G VI+ L+K
Sbjct: 354 DKYGGTALHAAALSGHVSTVKLLLENNAQ-VDATDVMKHTPLFRACEMGHKDVIQTLIKG 412
Query: 1119 D-RTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGH 1177
R ++ + + L AA GG+ADV ++L+ + ++ AG T + AA G+
Sbjct: 413 GARVDLVDQ----DGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 468
Query: 1178 TNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
N + V+ N K G T LH + G + ++ LL
Sbjct: 469 INCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 127 bits (307), Expect = 4e-28
Identities = 123/451 (27%), Positives = 201/451 (44%), Gaps = 32/451 (7%)
Query: 964 SALHLAAEHGYLQVCDALLT-NKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
S +H AA +G L+ N A + + + GRT L + L++ A +
Sbjct: 16 SQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKA-GADV 74
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
+ ++T LHLAA G KLLL AN D P+H ++ + + L L
Sbjct: 75 NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL 134
Query: 1083 Q-QHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT-GVISARNKLNDSTPLQLAA 1140
+ P V K+ T H +A + + ++ L+K D G+ K+ PL AA
Sbjct: 135 KFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKI----PLHWAA 190
Query: 1141 ---EGGHADVVRVLVRAGAS---CTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISS 1194
+ VR ++ A + ++ G T +H A G+ V+DV+ S + I+S
Sbjct: 191 NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITS 250
Query: 1195 -KKLGLTPLHIAAYYGQAETVRELLS-HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
L TPLH AA G A+ V LL + GT+ S++ G TPLH AA
Sbjct: 251 YDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS-------------QGATPLHYAA 297
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL-LHSTDR 1311
+ V++ L V+ D S+ G A G ++ +LS +++ ++ D+
Sbjct: 298 QSNFAETVKVFLKHPSVKDD--SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADK 355
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGAS 1371
+G T LH A+ GH V++LL A+++ATD TPL A + GH +V++ L + GA
Sbjct: 356 YGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGAR 415
Query: 1372 PKSETNLNCAPIWFAASENHNDVLEYLLHKE 1402
+ + +AA + DV + L+ +
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENK 446
Score = 122 bits (294), Expect = 1e-26
Identities = 124/479 (25%), Positives = 215/479 (44%), Gaps = 40/479 (8%)
Query: 680 NTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAAR 739
+ LL+ G V+ T + TALH+A + ++ LL A+ ++ + TPLH+ R
Sbjct: 65 DALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRAN-WMQKDLEEMTPLHLTTR 123
Query: 740 IPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVC 797
KC +LLK A T+D T +H +A + N + LL++ + +
Sbjct: 124 -HRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIK------HDSNIG 176
Query: 798 IYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKV 857
I D V G+ PL A P V H + + D + + + ++ D +G + LH+A V
Sbjct: 177 IPD-VEGKIPLHWAANHKDPSAV-HTVRCILD---AAPTESLLNWQDYEGRTPLHFA--V 229
Query: 858 TKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTAD 917
V + C I + ++ T H+ A+ G+ ++ ++ +
Sbjct: 230 ADGNVTVVDVLTSYESCNITSYDNL-------FRTPLHWAALLGHAQIVHLLLERNKSGT 282
Query: 918 VSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQV 977
+ +S G TPL A + V L + + D D+EGR++ AA G V
Sbjct: 283 IP-----SDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDV 337
Query: 978 CDALLTNKA--FINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHL 1035
+L+ K+ IN + G TALH AA++G+ VK L+ ++NA +D + K TPL
Sbjct: 338 LRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL-ENNAQVDATDVMKHTPLFR 396
Query: 1036 AAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKD 1095
A G +V + L++ GA +D D+ G +H AA ++V Q+ ++ N + +D
Sbjct: 397 ACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIE---NKINPNVQD 453
Query: 1096 --GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
G T AA G + + LM+ + I + T L + G+ D +++L+
Sbjct: 454 YAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK---EGRTALHWSCNNGYLDAIKLLL 509
Score = 118 bits (285), Expect = 2e-25
Identities = 117/439 (26%), Positives = 199/439 (45%), Gaps = 43/439 (9%)
Query: 666 SIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVET---LLGYGADV 722
++H +A Y + + L++ ++ + + LH A P+ V T +L
Sbjct: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTE 211
Query: 723 HIRGGKQRE--TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLA 778
+ + E TPLH A + DG+ + +L S N + D + TP+H AA G+
Sbjct: 212 SLLNWQDYEGRTPLHFA--VADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQ 269
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LLLE R I G TPL A +S + V+ + K SV
Sbjct: 270 IVHLLLE------RNKSGTIPSDSQGATPLHYAAQSNFAETVKVFL------KHPSVK-- 315
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
D D +G ++ +A ++V R ++ +++ D+++ ++ TA H A
Sbjct: 316 --DDSDLEGRTSFMWAAGKGSDDVL-----RTMLS--LKSDIDINMADKYGG-TALHAAA 365
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVF 958
++G+ + ++ + + D + + TPL AC GH ++ TL+ ARVD+
Sbjct: 366 LSGHVSTVKLLLENNAQVDATDVMKH------TPLFRACEMGHKDVIQTLIKGGARVDLV 419
Query: 959 DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH 1018
D +G S LH AA G VC L+ NK N + GRT L AA GY + + L+ ++
Sbjct: 420 DQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM-EN 478
Query: 1019 NAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDELGQKPIHAAAQNNYSE 1076
NA ++ + +T LH + +G ++ KLLL+ A N +E P+ A E
Sbjct: 479 NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHE 538
Query: 1077 VVQLFLQQHPNLVMATTKD 1095
V+Q F+ +H L +A +D
Sbjct: 539 VIQ-FMLEHGALSIAAIQD 556
Score = 68.1 bits (159), Expect = 3e-10
Identities = 49/164 (29%), Positives = 78/164 (47%), Gaps = 9/164 (5%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H AA GHV + LL+ VD T +T L A E V++TL+ GA V
Sbjct: 357 GGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARV 416
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + + LH AA + D C + L+++ PN G TP+ AA G + + +
Sbjct: 417 DL-VDQDGHSLLHWAALGGNADVCQI-LIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
L+E+ DP + K G T L +C + D ++ L++F
Sbjct: 475 LMENNADPNIQDK-------EGRTALHWSCNNGYLDAIKLLLDF 511
Score = 64.5 bits (150), Expect = 4e-09
Identities = 41/167 (24%), Positives = 79/167 (47%), Gaps = 1/167 (0%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ + A G+ ++R +LS ++ + G TALH AA V ++L++ A
Sbjct: 322 GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNA 381
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VDAT+ TPL A G + +++ A + D + + +H AA G+A + ++
Sbjct: 382 QVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQI 441
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L + K + + G T + A+ G+ +C +L + ++ +K
Sbjct: 442 LIEN-KINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK 487
Score = 62.1 bits (144), Expect = 2e-08
Identities = 41/129 (31%), Positives = 60/129 (46%), Gaps = 7/129 (5%)
Query: 98 GDTALHLAARRRD---VDMARILVDYGAVVDATNGA---GQTPLHIAAAEGDEPLVKYFY 151
G LH AA +D V R ++D N G+TPLH A A+G+ +V
Sbjct: 182 GKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLT 241
Query: 152 GVRA-NAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
+ N DN RTP+H AA GHA I+ LL ++ K+ G+T +H A+ +
Sbjct: 242 SYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNF 301
Query: 211 ADCAMMLFK 219
A+ + K
Sbjct: 302 AETVKVFLK 310
Score = 56.0 bits (129), Expect = 1e-06
Identities = 46/173 (26%), Positives = 75/173 (43%), Gaps = 3/173 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A +G+ S V+ LL + Q+ AT T L A D+ + L+ GA
Sbjct: 357 GGTALHAAALSGHVSTVKLLL--ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGA 414
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VD + G + LH AA G+ + + + N + D RTP+ AA G+ + +
Sbjct: 415 RVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQT 235
L + A + K+G T +H + NG+ D +L + + E+ T
Sbjct: 475 LMEN-NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYT 526
Score = 53.6 bits (123), Expect = 7e-06
Identities = 57/196 (29%), Positives = 86/196 (43%), Gaps = 21/196 (10%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY--TALHIAVESCKPAVVETLLGYG 719
+G S AA G ++ T+L +D+ D Y TALH A S + V+ LL
Sbjct: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
A V + TPL A + D L+K GA + +DG + +H AA GN
Sbjct: 381 AQVDAT-DVMKHTPLFRACEMGHKD-VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV 438
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF 839
+L+E+ +P V Y G TPLQ A + + L+E + A
Sbjct: 439 CQILIENKINP----NVQDY---AGRTPLQCAAYGGYINCMAVLME----------NNAD 481
Query: 840 IDAVDEDGASALHYAC 855
+ D++G +ALH++C
Sbjct: 482 PNIQDKEGRTALHWSC 497
Score = 52.4 bits (120), Expect = 2e-05
Identities = 40/160 (25%), Positives = 74/160 (46%), Gaps = 4/160 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL A G+ +V LL + + + + G T LH AA+ + ++ + + +V
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ-GATPLHYAAQSNFAETVKVFLKHPSV 314
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI--ADNEDRTPMHLAAENGHAAIIE 181
D ++ G+T AA +G + +++ ++++ I AD T +H AA +GH + ++
Sbjct: 315 KDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVK 374
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LL + A + T + A GH D L K G
Sbjct: 375 LLLEN-NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGG 413
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/157 (26%), Positives = 74/157 (47%), Gaps = 4/157 (2%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQT 133
G++ ++ L+ +A + K G T L +D A L+ GA V+ T+ + +T
Sbjct: 25 GDKGALQRLIVGNSALKDKEDQ-FGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRT 83
Query: 134 PLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKA--SI 191
LH+AA +G+ +K RAN D E+ TP+HL + + LL KF A +
Sbjct: 84 ALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL-KFMAPGEV 142
Query: 192 FERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
+ K+ T +H ++ + + +L K + +P+
Sbjct: 143 DTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPD 179
Score = 49.6 bits (113), Expect = 1e-04
Identities = 38/161 (23%), Positives = 67/161 (41%), Gaps = 6/161 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL L + + LL ++ TALH +A + + ++L+ + + +
Sbjct: 117 PLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIG 176
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIA------DNEDRTPMHLAAENGHAAI 179
+ G+ PLH AA D V + A D E RTP+H A +G+ +
Sbjct: 177 IPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTV 236
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+++L +I T +H A+L GHA +L ++
Sbjct: 237 VDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLER 277
>AF084382-1|AAC79456.1| 1065|Homo sapiens inversin protein protein.
Length = 1065
Score = 165 bits (402), Expect = 1e-39
Identities = 141/512 (27%), Positives = 230/512 (44%), Gaps = 28/512 (5%)
Query: 895 HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
H A+ G+ + +I S ++++ G TPL+ + + LL A
Sbjct: 19 HAAAVNGDKGALQRLIVGNSALK-----DKEDQFGRTPLMYCVLADRLDCADALLKAGAD 73
Query: 955 VDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
V+ D R+ALHLAA+ G + LLT +A K T LHL + + L
Sbjct: 74 VNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALL 133
Query: 1015 IRDHN-AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN- 1072
++ +D KQT LH +A E KLL++ +NI D G+ P+H AA +
Sbjct: 134 LKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHK 193
Query: 1073 --NYSEVVQLFLQQHPNLVMATTKD--GNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
+ V+ L P + +D G T H A G+V V++ L ++ + S N
Sbjct: 194 DPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDN 253
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCT-DENRAGLTAVHLAAEHGHTNVLDVMRST 1187
TPL AA GHA +V +L+ S T + G T +H AA+ + V
Sbjct: 254 LFR--TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+++ S G T AA G + +R +LS +KS+ ++ + G T
Sbjct: 312 PSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLS-----LKSDIDINMA------DKYGGTA 360
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH AA +G+ + V+LLL + Q DA ++ + PL AC GH ++ L+ A +
Sbjct: 361 LHAAALSGHVSTVKLLLEN-NAQVDA-TDVMKHTPLFRACEMGHKDVIQTLIKGGARV-D 417
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
D+ G + LH A+ G+ + ++L+ N D G TPL CAA G++N + +L E
Sbjct: 418 LVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME 477
Query: 1368 SGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+ A P + + ++ + + D ++ LL
Sbjct: 478 NNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 147 bits (355), Expect = 6e-34
Identities = 136/470 (28%), Positives = 209/470 (44%), Gaps = 27/470 (5%)
Query: 944 LVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAA 1003
L ++ N A D D GR+ L L DALL A +N + RTALHLAA
Sbjct: 30 LQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAA 89
Query: 1004 MNGYAHLVKFLI-RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDE 1060
G +K L+ R N M L++ TPLHL + LLL+ A +D D+
Sbjct: 90 QKGNYRFMKLLLTRRANWMQK--DLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDK 147
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQ---GSVKVIEELMK 1117
Q +H +A N E V+L ++ N+ + +G H AA +V + ++
Sbjct: 148 NKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV-EGKIPLHWAANHKDPSAVHTVRCILD 206
Query: 1118 FDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR-AGASCTDENRAGLTAVHLAAEHG 1176
T + TPL A G+ VV VL + T + T +H AA G
Sbjct: 207 AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLG 266
Query: 1177 HTNVLDVMRSTNTL-RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSL 1235
H ++ ++ N I S G TPLH AA AETV+ L H +VK ++
Sbjct: 267 HAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP--SVKDDSDL---- 320
Query: 1236 VPVLGAESGLTPLHLAAYNGNENVVRLLLN-SAGVQADAASNENGYNPLHLACFGGHMSI 1294
G T AA G+++V+R +L+ + + + A G LH A GH+S
Sbjct: 321 -------EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGG-TALHAAALSGHVST 372
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
V LLL +A++ +TD T L A GH +++ L+ GA ++ D++G + LH AA
Sbjct: 373 VKLLLENNAQV-DATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAA 431
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G+ +V ++L E+ +P + P+ AA + + + L+ D
Sbjct: 432 LGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNAD 481
Score = 130 bits (315), Expect = 4e-29
Identities = 141/521 (27%), Positives = 234/521 (44%), Gaps = 38/521 (7%)
Query: 703 AVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATE 762
AV K A+ ++G A + + + TPL + D CA LLK+GA NK
Sbjct: 22 AVNGDKGALQRLIVGNSA-LKDKEDQFGRTPLMYCV-LADRLDCADALLKAGADVNKTDH 79
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
T +H+AA+ GN + LLL + ++K + TPL + R P +
Sbjct: 80 SQRTALHLAAQKGNYRFMKLLLTRRANWMQKD-------LEEMTPLHLTTRHRSPKCLAL 132
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L++F+ GE +D D++ +ALH++ E VK LI++ +++
Sbjct: 133 LLKFMA--PGE------VDTQDKNKQTALHWSAYYNNPE---------HVKLLIKHDSNI 175
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ + H+ A + + + + A LN Q+ G TPL A G++
Sbjct: 176 GIPDVEG-KIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNV 234
Query: 943 QLVNTLLT-NHARVDVFDVEGRSALHLAAEHGYLQVCDALL-TNKAFINSKARNGRTALH 1000
+V+ L + + +D R+ LH AA G+ Q+ LL NK+ G T LH
Sbjct: 235 TVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLH 294
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID--AT 1058
AA + +A VK ++ H ++ D L+ +T AA G +V + +L L ++ID
Sbjct: 295 YAAQSNFAETVKVFLK-HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMA 353
Query: 1059 DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKF 1118
D+ G +HAAA + + V+L L+ + V AT +T A G VI+ L+K
Sbjct: 354 DKYGGTALHAAALSGHVSTVKLLLENNAQ-VDATDVMKHTPLFRACEMGHKDVIQTLIKG 412
Query: 1119 D-RTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGH 1177
R ++ + + L AA GG+ADV ++L+ + ++ AG T + AA G+
Sbjct: 413 GARVDLVDQ----DGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 468
Query: 1178 TNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
N + V+ N K G T LH + G + ++ LL
Sbjct: 469 INCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 127 bits (307), Expect = 4e-28
Identities = 123/451 (27%), Positives = 201/451 (44%), Gaps = 32/451 (7%)
Query: 964 SALHLAAEHGYLQVCDALLT-NKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
S +H AA +G L+ N A + + + GRT L + L++ A +
Sbjct: 16 SQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKA-GADV 74
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
+ ++T LHLAA G KLLL AN D P+H ++ + + L L
Sbjct: 75 NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL 134
Query: 1083 Q-QHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT-GVISARNKLNDSTPLQLAA 1140
+ P V K+ T H +A + + ++ L+K D G+ K+ PL AA
Sbjct: 135 KFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKI----PLHWAA 190
Query: 1141 ---EGGHADVVRVLVRAGAS---CTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISS 1194
+ VR ++ A + ++ G T +H A G+ V+DV+ S + I+S
Sbjct: 191 NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITS 250
Query: 1195 -KKLGLTPLHIAAYYGQAETVRELLS-HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
L TPLH AA G A+ V LL + GT+ S++ G TPLH AA
Sbjct: 251 YDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS-------------QGATPLHYAA 297
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL-LHSTDR 1311
+ V++ L V+ D S+ G A G ++ +LS +++ ++ D+
Sbjct: 298 QSNFAETVKVFLKHPSVKDD--SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADK 355
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGAS 1371
+G T LH A+ GH V++LL A+++ATD TPL A + GH +V++ L + GA
Sbjct: 356 YGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGAR 415
Query: 1372 PKSETNLNCAPIWFAASENHNDVLEYLLHKE 1402
+ + +AA + DV + L+ +
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENK 446
Score = 122 bits (294), Expect = 1e-26
Identities = 124/479 (25%), Positives = 215/479 (44%), Gaps = 40/479 (8%)
Query: 680 NTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAAR 739
+ LL+ G V+ T + TALH+A + ++ LL A+ ++ + TPLH+ R
Sbjct: 65 DALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRAN-WMQKDLEEMTPLHLTTR 123
Query: 740 IPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVC 797
KC +LLK A T+D T +H +A + N + LL++ + +
Sbjct: 124 -HRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIK------HDSNIG 176
Query: 798 IYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKV 857
I D V G+ PL A P V H + + D + + + ++ D +G + LH+A V
Sbjct: 177 IPD-VEGKIPLHWAANHKDPSAV-HTVRCILD---AAPTESLLNWQDYEGRTPLHFA--V 229
Query: 858 TKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTAD 917
V + C I + ++ T H+ A+ G+ ++ ++ +
Sbjct: 230 ADGNVTVVDVLTSYESCNITSYDNL-------FRTPLHWAALLGHAQIVHLLLERNKSGT 282
Query: 918 VSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQV 977
+ +S G TPL A + V L + + D D+EGR++ AA G V
Sbjct: 283 IP-----SDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDV 337
Query: 978 CDALLTNKA--FINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHL 1035
+L+ K+ IN + G TALH AA++G+ VK L+ ++NA +D + K TPL
Sbjct: 338 LRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL-ENNAQVDATDVMKHTPLFR 396
Query: 1036 AAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKD 1095
A G +V + L++ GA +D D+ G +H AA ++V Q+ ++ N + +D
Sbjct: 397 ACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIE---NKINPNVQD 453
Query: 1096 --GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
G T AA G + + LM+ + I + T L + G+ D +++L+
Sbjct: 454 YAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK---EGRTALHWSCNNGYLDAIKLLL 509
Score = 118 bits (285), Expect = 2e-25
Identities = 117/439 (26%), Positives = 199/439 (45%), Gaps = 43/439 (9%)
Query: 666 SIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVET---LLGYGADV 722
++H +A Y + + L++ ++ + + LH A P+ V T +L
Sbjct: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTE 211
Query: 723 HIRGGKQRE--TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLA 778
+ + E TPLH A + DG+ + +L S N + D + TP+H AA G+
Sbjct: 212 SLLNWQDYEGRTPLHFA--VADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQ 269
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LLLE R I G TPL A +S + V+ + K SV
Sbjct: 270 IVHLLLE------RNKSGTIPSDSQGATPLHYAAQSNFAETVKVFL------KHPSVK-- 315
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
D D +G ++ +A ++V R ++ +++ D+++ ++ TA H A
Sbjct: 316 --DDSDLEGRTSFMWAAGKGSDDVL-----RTMLS--LKSDIDINMADKYGG-TALHAAA 365
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVF 958
++G+ + ++ + + D + + TPL AC GH ++ TL+ ARVD+
Sbjct: 366 LSGHVSTVKLLLENNAQVDATDVMKH------TPLFRACEMGHKDVIQTLIKGGARVDLV 419
Query: 959 DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH 1018
D +G S LH AA G VC L+ NK N + GRT L AA GY + + L+ ++
Sbjct: 420 DQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM-EN 478
Query: 1019 NAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDELGQKPIHAAAQNNYSE 1076
NA ++ + +T LH + +G ++ KLLL+ A N +E P+ A E
Sbjct: 479 NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHE 538
Query: 1077 VVQLFLQQHPNLVMATTKD 1095
V+Q F+ +H L +A +D
Sbjct: 539 VIQ-FMLEHGALSIAAIQD 556
Score = 68.1 bits (159), Expect = 3e-10
Identities = 49/164 (29%), Positives = 78/164 (47%), Gaps = 9/164 (5%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H AA GHV + LL+ VD T +T L A E V++TL+ GA V
Sbjct: 357 GGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARV 416
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + + LH AA + D C + L+++ PN G TP+ AA G + + +
Sbjct: 417 DL-VDQDGHSLLHWAALGGNADVCQI-LIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
L+E+ DP + K G T L +C + D ++ L++F
Sbjct: 475 LMENNADPNIQDK-------EGRTALHWSCNNGYLDAIKLLLDF 511
Score = 64.5 bits (150), Expect = 4e-09
Identities = 41/167 (24%), Positives = 79/167 (47%), Gaps = 1/167 (0%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ + A G+ ++R +LS ++ + G TALH AA V ++L++ A
Sbjct: 322 GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNA 381
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VDAT+ TPL A G + +++ A + D + + +H AA G+A + ++
Sbjct: 382 QVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQI 441
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L + K + + G T + A+ G+ +C +L + ++ +K
Sbjct: 442 LIEN-KINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK 487
Score = 62.1 bits (144), Expect = 2e-08
Identities = 41/129 (31%), Positives = 60/129 (46%), Gaps = 7/129 (5%)
Query: 98 GDTALHLAARRRD---VDMARILVDYGAVVDATNGA---GQTPLHIAAAEGDEPLVKYFY 151
G LH AA +D V R ++D N G+TPLH A A+G+ +V
Sbjct: 182 GKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLT 241
Query: 152 GVRA-NAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
+ N DN RTP+H AA GHA I+ LL ++ K+ G+T +H A+ +
Sbjct: 242 SYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNF 301
Query: 211 ADCAMMLFK 219
A+ + K
Sbjct: 302 AETVKVFLK 310
Score = 56.0 bits (129), Expect = 1e-06
Identities = 46/173 (26%), Positives = 75/173 (43%), Gaps = 3/173 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A +G+ S V+ LL + Q+ AT T L A D+ + L+ GA
Sbjct: 357 GGTALHAAALSGHVSTVKLLL--ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGA 414
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VD + G + LH AA G+ + + + N + D RTP+ AA G+ + +
Sbjct: 415 RVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQT 235
L + A + K+G T +H + NG+ D +L + + E+ T
Sbjct: 475 LMEN-NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYT 526
Score = 53.6 bits (123), Expect = 7e-06
Identities = 57/196 (29%), Positives = 86/196 (43%), Gaps = 21/196 (10%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY--TALHIAVESCKPAVVETLLGYG 719
+G S AA G ++ T+L +D+ D Y TALH A S + V+ LL
Sbjct: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
A V + TPL A + D L+K GA + +DG + +H AA GN
Sbjct: 381 AQVDAT-DVMKHTPLFRACEMGHKD-VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV 438
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF 839
+L+E+ +P V Y G TPLQ A + + L+E + A
Sbjct: 439 CQILIENKINP----NVQDY---AGRTPLQCAAYGGYINCMAVLME----------NNAD 481
Query: 840 IDAVDEDGASALHYAC 855
+ D++G +ALH++C
Sbjct: 482 PNIQDKEGRTALHWSC 497
Score = 52.4 bits (120), Expect = 2e-05
Identities = 40/160 (25%), Positives = 74/160 (46%), Gaps = 4/160 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL A G+ +V LL + + + + G T LH AA+ + ++ + + +V
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ-GATPLHYAAQSNFAETVKVFLKHPSV 314
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI--ADNEDRTPMHLAAENGHAAIIE 181
D ++ G+T AA +G + +++ ++++ I AD T +H AA +GH + ++
Sbjct: 315 KDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVK 374
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LL + A + T + A GH D L K G
Sbjct: 375 LLLEN-NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGG 413
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/157 (26%), Positives = 74/157 (47%), Gaps = 4/157 (2%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQT 133
G++ ++ L+ +A + K G T L +D A L+ GA V+ T+ + +T
Sbjct: 25 GDKGALQRLIVGNSALKDKEDQ-FGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRT 83
Query: 134 PLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKA--SI 191
LH+AA +G+ +K RAN D E+ TP+HL + + LL KF A +
Sbjct: 84 ALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL-KFMAPGEV 142
Query: 192 FERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
+ K+ T +H ++ + + +L K + +P+
Sbjct: 143 DTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPD 179
Score = 49.6 bits (113), Expect = 1e-04
Identities = 38/161 (23%), Positives = 67/161 (41%), Gaps = 6/161 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL L + + LL ++ TALH +A + + ++L+ + + +
Sbjct: 117 PLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIG 176
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIA------DNEDRTPMHLAAENGHAAI 179
+ G+ PLH AA D V + A D E RTP+H A +G+ +
Sbjct: 177 IPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTV 236
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+++L +I T +H A+L GHA +L ++
Sbjct: 237 VDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLER 277
>AF084367-1|AAC79436.1| 1065|Homo sapiens inversin protein protein.
Length = 1065
Score = 165 bits (402), Expect = 1e-39
Identities = 141/512 (27%), Positives = 230/512 (44%), Gaps = 28/512 (5%)
Query: 895 HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
H A+ G+ + +I S ++++ G TPL+ + + LL A
Sbjct: 19 HAAAVNGDKGALQRLIVGNSALK-----DKEDQFGRTPLMYCVLADRLDCADALLKAGAD 73
Query: 955 VDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
V+ D R+ALHLAA+ G + LLT +A K T LHL + + L
Sbjct: 74 VNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALL 133
Query: 1015 IRDHN-AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN- 1072
++ +D KQT LH +A E KLL++ +NI D G+ P+H AA +
Sbjct: 134 LKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHK 193
Query: 1073 --NYSEVVQLFLQQHPNLVMATTKD--GNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
+ V+ L P + +D G T H A G+V V++ L ++ + S N
Sbjct: 194 DPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDN 253
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCT-DENRAGLTAVHLAAEHGHTNVLDVMRST 1187
TPL AA GHA +V +L+ S T + G T +H AA+ + V
Sbjct: 254 LFR--TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH 311
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+++ S G T AA G + +R +LS +KS+ ++ + G T
Sbjct: 312 PSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLS-----LKSDIDINMA------DKYGGTA 360
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH AA +G+ + V+LLL + Q DA ++ + PL AC GH ++ L+ A +
Sbjct: 361 LHAAALSGHVSTVKLLLEN-NAQVDA-TDVMKHTPLFRACEMGHKDVIQTLIKGGARV-D 417
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
D+ G + LH A+ G+ + ++L+ N D G TPL CAA G++N + +L E
Sbjct: 418 LVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME 477
Query: 1368 SGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+ A P + + ++ + + D ++ LL
Sbjct: 478 NNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 147 bits (355), Expect = 6e-34
Identities = 136/470 (28%), Positives = 209/470 (44%), Gaps = 27/470 (5%)
Query: 944 LVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAA 1003
L ++ N A D D GR+ L L DALL A +N + RTALHLAA
Sbjct: 30 LQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAA 89
Query: 1004 MNGYAHLVKFLI-RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDE 1060
G +K L+ R N M L++ TPLHL + LLL+ A +D D+
Sbjct: 90 QKGNYRFMKLLLTRRANWMQK--DLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDK 147
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQ---GSVKVIEELMK 1117
Q +H +A N E V+L ++ N+ + +G H AA +V + ++
Sbjct: 148 NKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV-EGKIPLHWAANHKDPSAVHTVRCILD 206
Query: 1118 FDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR-AGASCTDENRAGLTAVHLAAEHG 1176
T + TPL A G+ VV VL + T + T +H AA G
Sbjct: 207 AAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLG 266
Query: 1177 HTNVLDVMRSTNTL-RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSL 1235
H ++ ++ N I S G TPLH AA AETV+ L H +VK ++
Sbjct: 267 HAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP--SVKDDSDL---- 320
Query: 1236 VPVLGAESGLTPLHLAAYNGNENVVRLLLN-SAGVQADAASNENGYNPLHLACFGGHMSI 1294
G T AA G+++V+R +L+ + + + A G LH A GH+S
Sbjct: 321 -------EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGG-TALHAAALSGHVST 372
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
V LLL +A++ +TD T L A GH +++ L+ GA ++ D++G + LH AA
Sbjct: 373 VKLLLENNAQV-DATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAA 431
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G+ +V ++L E+ +P + P+ AA + + + L+ D
Sbjct: 432 LGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNAD 481
Score = 130 bits (315), Expect = 4e-29
Identities = 141/521 (27%), Positives = 234/521 (44%), Gaps = 38/521 (7%)
Query: 703 AVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATE 762
AV K A+ ++G A + + + TPL + D CA LLK+GA NK
Sbjct: 22 AVNGDKGALQRLIVGNSA-LKDKEDQFGRTPLMYCV-LADRLDCADALLKAGADVNKTDH 79
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
T +H+AA+ GN + LLL + ++K + TPL + R P +
Sbjct: 80 SQRTALHLAAQKGNYRFMKLLLTRRANWMQKD-------LEEMTPLHLTTRHRSPKCLAL 132
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L++F+ GE +D D++ +ALH++ E VK LI++ +++
Sbjct: 133 LLKFMA--PGE------VDTQDKNKQTALHWSAYYNNPE---------HVKLLIKHDSNI 175
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ + H+ A + + + + A LN Q+ G TPL A G++
Sbjct: 176 GIPDVEG-KIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNV 234
Query: 943 QLVNTLLT-NHARVDVFDVEGRSALHLAAEHGYLQVCDALL-TNKAFINSKARNGRTALH 1000
+V+ L + + +D R+ LH AA G+ Q+ LL NK+ G T LH
Sbjct: 235 TVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLH 294
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID--AT 1058
AA + +A VK ++ H ++ D L+ +T AA G +V + +L L ++ID
Sbjct: 295 YAAQSNFAETVKVFLK-HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMA 353
Query: 1059 DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKF 1118
D+ G +HAAA + + V+L L+ + V AT +T A G VI+ L+K
Sbjct: 354 DKYGGTALHAAALSGHVSTVKLLLENNAQ-VDATDVMKHTPLFRACEMGHKDVIQTLIKG 412
Query: 1119 D-RTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGH 1177
R ++ + + L AA GG+ADV ++L+ + ++ AG T + AA G+
Sbjct: 413 GARVDLVDQ----DGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 468
Query: 1178 TNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
N + V+ N K G T LH + G + ++ LL
Sbjct: 469 INCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Score = 127 bits (307), Expect = 4e-28
Identities = 123/451 (27%), Positives = 201/451 (44%), Gaps = 32/451 (7%)
Query: 964 SALHLAAEHGYLQVCDALLT-NKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
S +H AA +G L+ N A + + + GRT L + L++ A +
Sbjct: 16 SQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKA-GADV 74
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
+ ++T LHLAA G KLLL AN D P+H ++ + + L L
Sbjct: 75 NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL 134
Query: 1083 Q-QHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT-GVISARNKLNDSTPLQLAA 1140
+ P V K+ T H +A + + ++ L+K D G+ K+ PL AA
Sbjct: 135 KFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKI----PLHWAA 190
Query: 1141 ---EGGHADVVRVLVRAGAS---CTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISS 1194
+ VR ++ A + ++ G T +H A G+ V+DV+ S + I+S
Sbjct: 191 NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITS 250
Query: 1195 -KKLGLTPLHIAAYYGQAETVRELLS-HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
L TPLH AA G A+ V LL + GT+ S++ G TPLH AA
Sbjct: 251 YDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS-------------QGATPLHYAA 297
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL-LHSTDR 1311
+ V++ L V+ D S+ G A G ++ +LS +++ ++ D+
Sbjct: 298 QSNFAETVKVFLKHPSVKDD--SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADK 355
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGAS 1371
+G T LH A+ GH V++LL A+++ATD TPL A + GH +V++ L + GA
Sbjct: 356 YGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGAR 415
Query: 1372 PKSETNLNCAPIWFAASENHNDVLEYLLHKE 1402
+ + +AA + DV + L+ +
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENK 446
Score = 122 bits (294), Expect = 1e-26
Identities = 124/479 (25%), Positives = 215/479 (44%), Gaps = 40/479 (8%)
Query: 680 NTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAAR 739
+ LL+ G V+ T + TALH+A + ++ LL A+ ++ + TPLH+ R
Sbjct: 65 DALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRAN-WMQKDLEEMTPLHLTTR 123
Query: 740 IPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVC 797
KC +LLK A T+D T +H +A + N + LL++ + +
Sbjct: 124 -HRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIK------HDSNIG 176
Query: 798 IYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKV 857
I D V G+ PL A P V H + + D + + + ++ D +G + LH+A V
Sbjct: 177 IPD-VEGKIPLHWAANHKDPSAV-HTVRCILD---AAPTESLLNWQDYEGRTPLHFA--V 229
Query: 858 TKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTAD 917
V + C I + ++ T H+ A+ G+ ++ ++ +
Sbjct: 230 ADGNVTVVDVLTSYESCNITSYDNL-------FRTPLHWAALLGHAQIVHLLLERNKSGT 282
Query: 918 VSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQV 977
+ +S G TPL A + V L + + D D+EGR++ AA G V
Sbjct: 283 IP-----SDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDV 337
Query: 978 CDALLTNKA--FINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHL 1035
+L+ K+ IN + G TALH AA++G+ VK L+ ++NA +D + K TPL
Sbjct: 338 LRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL-ENNAQVDATDVMKHTPLFR 396
Query: 1036 AAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKD 1095
A G +V + L++ GA +D D+ G +H AA ++V Q+ ++ N + +D
Sbjct: 397 ACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIE---NKINPNVQD 453
Query: 1096 --GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
G T AA G + + LM+ + I + T L + G+ D +++L+
Sbjct: 454 YAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK---EGRTALHWSCNNGYLDAIKLLL 509
Score = 118 bits (285), Expect = 2e-25
Identities = 117/439 (26%), Positives = 199/439 (45%), Gaps = 43/439 (9%)
Query: 666 SIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVET---LLGYGADV 722
++H +A Y + + L++ ++ + + LH A P+ V T +L
Sbjct: 152 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTE 211
Query: 723 HIRGGKQRE--TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLA 778
+ + E TPLH A + DG+ + +L S N + D + TP+H AA G+
Sbjct: 212 SLLNWQDYEGRTPLHFA--VADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQ 269
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LLLE R I G TPL A +S + V+ + K SV
Sbjct: 270 IVHLLLE------RNKSGTIPSDSQGATPLHYAAQSNFAETVKVFL------KHPSVK-- 315
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
D D +G ++ +A ++V R ++ +++ D+++ ++ TA H A
Sbjct: 316 --DDSDLEGRTSFMWAAGKGSDDVL-----RTMLS--LKSDIDINMADKYGG-TALHAAA 365
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVF 958
++G+ + ++ + + D + + TPL AC GH ++ TL+ ARVD+
Sbjct: 366 LSGHVSTVKLLLENNAQVDATDVMKH------TPLFRACEMGHKDVIQTLIKGGARVDLV 419
Query: 959 DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH 1018
D +G S LH AA G VC L+ NK N + GRT L AA GY + + L+ ++
Sbjct: 420 DQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM-EN 478
Query: 1019 NAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDELGQKPIHAAAQNNYSE 1076
NA ++ + +T LH + +G ++ KLLL+ A N +E P+ A E
Sbjct: 479 NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHE 538
Query: 1077 VVQLFLQQHPNLVMATTKD 1095
V+Q F+ +H L +A +D
Sbjct: 539 VIQ-FMLEHGALSIAAIQD 556
Score = 68.1 bits (159), Expect = 3e-10
Identities = 49/164 (29%), Positives = 78/164 (47%), Gaps = 9/164 (5%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H AA GHV + LL+ VD T +T L A E V++TL+ GA V
Sbjct: 357 GGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARV 416
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + + LH AA + D C + L+++ PN G TP+ AA G + + +
Sbjct: 417 DL-VDQDGHSLLHWAALGGNADVCQI-LIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
L+E+ DP + K G T L +C + D ++ L++F
Sbjct: 475 LMENNADPNIQDK-------EGRTALHWSCNNGYLDAIKLLLDF 511
Score = 64.5 bits (150), Expect = 4e-09
Identities = 41/167 (24%), Positives = 79/167 (47%), Gaps = 1/167 (0%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ + A G+ ++R +LS ++ + G TALH AA V ++L++ A
Sbjct: 322 GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNA 381
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VDAT+ TPL A G + +++ A + D + + +H AA G+A + ++
Sbjct: 382 QVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQI 441
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L + K + + G T + A+ G+ +C +L + ++ +K
Sbjct: 442 LIEN-KINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK 487
Score = 62.1 bits (144), Expect = 2e-08
Identities = 41/129 (31%), Positives = 60/129 (46%), Gaps = 7/129 (5%)
Query: 98 GDTALHLAARRRD---VDMARILVDYGAVVDATNGA---GQTPLHIAAAEGDEPLVKYFY 151
G LH AA +D V R ++D N G+TPLH A A+G+ +V
Sbjct: 182 GKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLT 241
Query: 152 GVRA-NAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
+ N DN RTP+H AA GHA I+ LL ++ K+ G+T +H A+ +
Sbjct: 242 SYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNF 301
Query: 211 ADCAMMLFK 219
A+ + K
Sbjct: 302 AETVKVFLK 310
Score = 56.0 bits (129), Expect = 1e-06
Identities = 46/173 (26%), Positives = 75/173 (43%), Gaps = 3/173 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A +G+ S V+ LL + Q+ AT T L A D+ + L+ GA
Sbjct: 357 GGTALHAAALSGHVSTVKLLL--ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGA 414
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VD + G + LH AA G+ + + + N + D RTP+ AA G+ + +
Sbjct: 415 RVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQT 235
L + A + K+G T +H + NG+ D +L + + E+ T
Sbjct: 475 LMEN-NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYT 526
Score = 53.6 bits (123), Expect = 7e-06
Identities = 57/196 (29%), Positives = 86/196 (43%), Gaps = 21/196 (10%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY--TALHIAVESCKPAVVETLLGYG 719
+G S AA G ++ T+L +D+ D Y TALH A S + V+ LL
Sbjct: 321 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 380
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
A V + TPL A + D L+K GA + +DG + +H AA GN
Sbjct: 381 AQVDAT-DVMKHTPLFRACEMGHKD-VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV 438
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF 839
+L+E+ +P V Y G TPLQ A + + L+E + A
Sbjct: 439 CQILIENKINP----NVQDY---AGRTPLQCAAYGGYINCMAVLME----------NNAD 481
Query: 840 IDAVDEDGASALHYAC 855
+ D++G +ALH++C
Sbjct: 482 PNIQDKEGRTALHWSC 497
Score = 52.4 bits (120), Expect = 2e-05
Identities = 40/160 (25%), Positives = 74/160 (46%), Gaps = 4/160 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL A G+ +V LL + + + + G T LH AA+ + ++ + + +V
Sbjct: 256 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ-GATPLHYAAQSNFAETVKVFLKHPSV 314
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI--ADNEDRTPMHLAAENGHAAIIE 181
D ++ G+T AA +G + +++ ++++ I AD T +H AA +GH + ++
Sbjct: 315 KDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVK 374
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LL + A + T + A GH D L K G
Sbjct: 375 LLLEN-NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGG 413
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/157 (26%), Positives = 74/157 (47%), Gaps = 4/157 (2%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQT 133
G++ ++ L+ +A + K G T L +D A L+ GA V+ T+ + +T
Sbjct: 25 GDKGALQRLIVGNSALKDKEDQ-FGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRT 83
Query: 134 PLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKA--SI 191
LH+AA +G+ +K RAN D E+ TP+HL + + LL KF A +
Sbjct: 84 ALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL-KFMAPGEV 142
Query: 192 FERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
+ K+ T +H ++ + + +L K + +P+
Sbjct: 143 DTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPD 179
Score = 49.6 bits (113), Expect = 1e-04
Identities = 38/161 (23%), Positives = 67/161 (41%), Gaps = 6/161 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL L + + LL ++ TALH +A + + ++L+ + + +
Sbjct: 117 PLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIG 176
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIA------DNEDRTPMHLAAENGHAAI 179
+ G+ PLH AA D V + A D E RTP+H A +G+ +
Sbjct: 177 IPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTV 236
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+++L +I T +H A+L GHA +L ++
Sbjct: 237 VDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLER 277
>AF308285-1|AAG48253.1| 1188|Homo sapiens serologically defined breast
cancer antigen NY-BR-16 protein.
Length = 1188
Score = 165 bits (401), Expect = 2e-39
Identities = 158/551 (28%), Positives = 251/551 (45%), Gaps = 34/551 (6%)
Query: 920 RALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGR-SALHLAAEHGYLQVC 978
R++N G + L +AC G+ +L LL HA V+ ++G + L AA G++++
Sbjct: 258 RSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIV 317
Query: 979 DALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
LL +KA +N+++ G TAL A GY +VK L+ + A I+ TPL A +
Sbjct: 318 KLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL-ESGASIEDHNENGHTPLMEAGS 376
Query: 1039 SGQIEVCKLLLELGANIDA-TDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGN 1097
+G +EV +LLLE GA I+ ++E + + A + E+V+ L+ + T + +
Sbjct: 377 AGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTD-EMH 435
Query: 1098 TCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGAS 1157
T A + G V+V L+ D ++ +S PL LAA GGH ++ +L+ GAS
Sbjct: 436 TALMEACMDGHVEVARLLL--DSGAQVNMPADSFES-PLTLAACGGHVELAALLIERGAS 492
Query: 1158 CTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT-LRISSKKLGLTPLHIAAYYGQAETVRE 1216
+ N G T + AA GH ++ ++ + +++ T L +A G E
Sbjct: 493 LEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADF 552
Query: 1217 LLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASN 1276
L+ G + LG TPL AA G+ +V+ LL +AG A +
Sbjct: 553 LIK-----------AGADIE--LGCS---TPLMEAAQEGHLELVKYLL-AAGANVHATT- 594
Query: 1277 ENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG 1336
G L AC GH + +LL A+L H ++ G+T L A+ GH V+ L+ +G
Sbjct: 595 ATGDTALTYACENGHTDVADVLLQAGADLEHESEG-GRTPLMKAARAGHVCTVQFLISKG 653
Query: 1337 AEINATDKNGWTPLHCAAKAG-HLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVL 1395
AE + + T L A AG HL VV+LL GA P + A H V
Sbjct: 654 AECESEPQLIMTILSALACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAPKGGHTSVG 713
Query: 1396 EYLLHKEHDTQSLMDDKRFVYNLMVCSKNHN---NIPIEEFVLVSPAPVDTAAKLSNIYI 1452
YLL ++ L V L S + N +P++ +V P P + +N+
Sbjct: 714 CYLL--DYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVP-PQEPDKPPANVAT 770
Query: 1453 NLSTKEKERAK 1463
L + K +K
Sbjct: 771 TLPIRNKAASK 781
Score = 155 bits (375), Expect = 2e-36
Identities = 137/439 (31%), Positives = 211/439 (48%), Gaps = 31/439 (7%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
++VK L+ + ADV+ Q+ + TA Y G DV+ ++ + ++ N G
Sbjct: 315 KIVKLLLAHKADVNAQSSTGN-TALTYACAGGYVDVVKVLL------ESGASIEDHNENG 367
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGR-SALHLAAEHGYLQVCDALLTNKAFI 988
TPL+ A GH+++ LL N A ++ E + SAL LA G+L++ LL A
Sbjct: 368 HTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQ 427
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
K TAL A M+G+ + + L+ D A +++ ++PL LAA G +E+ LL
Sbjct: 428 EHKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVELAALL 486
Query: 1049 LELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGS 1108
+E GA+++ ++ G P+ AA+ + E+V L L Q N+ T + T +A G
Sbjct: 487 IERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGF 546
Query: 1109 VKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTA 1168
++V + L+K A +L STPL AA+ GH ++V+ L+ AGA+ G TA
Sbjct: 547 LEVADFLIK------AGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600
Query: 1169 VHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSE 1228
+ A E+GHT+V DV+ + G TPL AA G TV+ L+S +SE
Sbjct: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK-GAECESE 659
Query: 1229 APTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASN-ENGYNPLHLAC 1287
++++ L G HLA VV LLL AD ++G L A
Sbjct: 660 PQLIMTILSALACAGG----HLA-------VVELLLAHG---ADPTHRLKDGSTMLIEAP 705
Query: 1288 FGGHMSIVGLLLSRSAELL 1306
GGH S+ LL LL
Sbjct: 706 KGGHTSVGCYLLDYPNNLL 724
Score = 154 bits (374), Expect = 3e-36
Identities = 150/517 (29%), Positives = 223/517 (43%), Gaps = 33/517 (6%)
Query: 897 CAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVD 956
CA+ +T M A STA+ ++ NR L AC G + V LL V+
Sbjct: 210 CALDEAAAALTRMRAE-STANAGQSDNRS-------LAEACSEGDVNAVRKLLIEGRSVN 261
Query: 957 VFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGR-TALHLAAMNGYAHLVKFLI 1015
EG S L LA GY ++ LL A + + G T L AA G+ +VK L+
Sbjct: 262 EHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLL 321
Query: 1016 RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYS 1075
H A ++ + T L A A G ++V K+LLE GA+I+ +E G P+ A +
Sbjct: 322 A-HKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHV 380
Query: 1076 EVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTP 1135
EV +L L+ + + + + +A +G ++++ L++ G T
Sbjct: 381 EVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE---AGADQEHKTDEMHTA 437
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK 1195
L A GH +V R+L+ +GA + + + LAA GH + ++
Sbjct: 438 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVN 497
Query: 1196 KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNG 1255
G TPL AA G E V LL G + + E+ T L LA G
Sbjct: 498 DEGYTPLMEAAREGHEEMVALLLGQ-----------GAN-INAQTEETQETALTLACCGG 545
Query: 1256 NENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKT 1315
V L+ AG + + PL A GH+ +V LL+ A +H+T G T
Sbjct: 546 FLEVADFLI-KAGADIELGCS----TPLMEAAQEGHLELVKYLLAAGAN-VHATTATGDT 599
Query: 1316 GLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSE 1375
L A +GH + +VLL GA++ + G TPL AA+AGH+ V+ L GA +SE
Sbjct: 600 ALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGAECESE 659
Query: 1376 TNLNCAPI-WFAASENHNDVLEYLL-HKEHDTQSLMD 1410
L + A + H V+E LL H T L D
Sbjct: 660 PQLIMTILSALACAGGHLAVVELLLAHGADPTHRLKD 696
Score = 149 bits (360), Expect = 1e-34
Identities = 136/516 (26%), Positives = 222/516 (43%), Gaps = 23/516 (4%)
Query: 910 IAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
I +STAD +A + ++C T + + + + RS
Sbjct: 184 IGKLSTAD-GKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 242
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKK 1029
+E G + LL +N G + L LA GY L + L+ H + D
Sbjct: 243 SE-GDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGD 301
Query: 1030 QTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
TPL AA G +++ KLLL A+++A G + A Y +VV++ L+ + +
Sbjct: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGAS-I 360
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVR 1149
++G+T A G V+V L++ + G+ + N+ +S L LA GH ++VR
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLE-NGAGINTHSNEFKESA-LTLACYKGHLEMVR 418
Query: 1150 VLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYG 1209
L+ AGA + TA+ A GH V ++ + +PL +AA G
Sbjct: 419 FLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG 478
Query: 1210 QAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGV 1269
E L+ G SL V + G TPL AA G+E +V LLL G
Sbjct: 479 HVELAALLIER-----------GASLEEV--NDEGYTPLMEAAREGHEEMVALLLGQ-GA 524
Query: 1270 QADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMV 1329
+A + E L LAC GG + + L+ A++ + T L A+ GH ++V
Sbjct: 525 NINAQTEETQETALTLACCGGFLEVADFLIKAGADI----ELGCSTPLMEAAQEGHLELV 580
Query: 1330 EVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASE 1389
+ LL GA ++AT G T L A + GH +V +L ++GA + E+ P+ AA
Sbjct: 581 KYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARA 640
Query: 1390 NHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNH 1425
H +++L+ K + +S + + + C+ H
Sbjct: 641 GHVCTVQFLISKGAECESEPQLIMTILSALACAGGH 676
Score = 100 bits (239), Expect = 6e-20
Identities = 113/433 (26%), Positives = 182/433 (42%), Gaps = 36/433 (8%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A G+V ++ LL+ G S++ + +T L A + V LL GA +
Sbjct: 334 GNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGI 393
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + +E+ L +A + LL++GA T++ T + A G++ L
Sbjct: 394 NTHSNEFKESALTLAC-YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 452
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL+ G + E+PL +A ++ LIE +G S ++
Sbjct: 453 LLDSGAQVNMPAD-------SFESPLTLAACGGHVELAALLIE-----RGAS-----LEE 495
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
V+++G + L A + EE+ V L+ GA+++ QT ETA G
Sbjct: 496 VNDEGYTPLMEAAREGHEEM---------VALLLGQGANINAQTEETQETALTLACCGGF 546
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
+V +I + AD+ + TPL+ A GH++LV LL A V G
Sbjct: 547 LEVADFLIK--AGADIELGCS-------TPLMEAAQEGHLELVKYLLAAGANVHATTATG 597
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+AL A E+G+ V D LL A + ++ GRT L AA G+ V+FLI
Sbjct: 598 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGAECE 657
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
L LA A G + V +LLL GA+ + G + A + ++ V L
Sbjct: 658 SEPQLIMTILSALACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAPKGGHTSVGCYLL 717
Query: 1083 QQHPNLVMATTKD 1095
NL+ A D
Sbjct: 718 DYPNNLLSAPPPD 730
Score = 99 bits (238), Expect = 8e-20
Identities = 128/490 (26%), Positives = 207/490 (42%), Gaps = 47/490 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESV-DVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
+G + A G+ + LL +V D + T L A +V+ LL + A
Sbjct: 266 EGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKA 325
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
DV+ + T L A D +LL+SGA E+G TP+ A G++
Sbjct: 326 DVNAQSSTGN-TALTYACAGGYVD-VVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVA 383
Query: 781 VLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKD--HKGESVSTA 838
LLLE+G + + E+ L +AC ++VR L+E D HK + + TA
Sbjct: 384 RLLLENGAG------INTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTA 437
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
++A DG H +V + L+++GA V++ + E+ A
Sbjct: 438 LMEAC-MDG----HV----------------EVARLLLDSGAQVNMPA-DSFESPLTLAA 475
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVF 958
G+ ++ +I + +L N G+TPL+ A GH ++V LL A ++
Sbjct: 476 CGGHVELAALLI------ERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQ 529
Query: 959 DVEGR-SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRD 1017
E + +AL LA G+L+V D L+ A I T L AA G+ LVK+L+
Sbjct: 530 TEETQETALTLACCGGFLEVADFLIKAGADIELGC---STPLMEAAQEGHLELVKYLLA- 585
Query: 1018 HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEV 1077
A + T T L A +G +V +LL+ GA+++ E G+ P+ AA+ +
Sbjct: 586 AGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCT 645
Query: 1078 VQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
VQ + + + +A G + V+E L+ G + ST L
Sbjct: 646 VQFLISKGAECESEPQLIMTILSALACAGGHLAVVELLLAH---GADPTHRLKDGSTMLI 702
Query: 1138 LAAEGGHADV 1147
A +GGH V
Sbjct: 703 EAPKGGHTSV 712
Score = 69.3 bits (162), Expect = 1e-10
Identities = 51/153 (33%), Positives = 72/153 (47%), Gaps = 4/153 (2%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL+ A + G+ +V+ LL+A + ATT GDTAL A D+A +L+ GA ++
Sbjct: 567 PLMEAAQEGHLELVKYLLAA--GANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMH-LAAENGHAAIIELLA 184
+ G+TPL AA G V++ A T + LA GH A++ELL
Sbjct: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGAECESEPQLIMTILSALACAGGHLAVVELLL 684
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
A R KDGST++ A GH L
Sbjct: 685 -AHGADPTHRLKDGSTMLIEAPKGGHTSVGCYL 716
Score = 66.1 bits (154), Expect = 1e-09
Identities = 48/168 (28%), Positives = 81/168 (48%), Gaps = 4/168 (2%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL+ A G+ +V+ LL A A+ + A + G+TAL A VD+ ++L++ GA ++
Sbjct: 304 PLMAAANGGHVKIVK-LLLAHKAD-VNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 361
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAAENGHAAIIELLA 184
N G TPL A + G + + A NE + + + LA GH ++ L
Sbjct: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 421
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFE 232
+ A +T + T + A ++GH + A +L G ++MP FE
Sbjct: 422 EA-GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 468
Score = 59.7 bits (138), Expect = 1e-07
Identities = 50/161 (31%), Positives = 78/161 (48%), Gaps = 4/161 (2%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G+ MVR LL A ++ K T TAL A V++AR+L+D GA V+
Sbjct: 405 LTLACYKGHLEMVRFLLEAGADQEHK--TDEMHTALMEACMDGHVEVARLLLDSGAQVNM 462
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ ++PL +AA G L A+ ++E TP+ AA GH ++ LL +
Sbjct: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
Query: 187 FKASIFERTKD-GSTLMHIASLNGHADCAMMLFKKGVYLHM 226
A+I +T++ T + +A G + A L K G + +
Sbjct: 523 -GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL 562
Score = 51.6 bits (118), Expect = 3e-05
Identities = 46/160 (28%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G+ + L+ + L+ G T L AAR +M +L+ GA ++
Sbjct: 470 PLTLAACGGHVELAALLI--ERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527
Query: 126 A-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A T +T L +A G + + ++A A I + TP+ AA+ GH +++ L
Sbjct: 528 AQTEETQETALTLACCGGFLEVADFL--IKAGADI-ELGCSTPLMEAAQEGHLELVKYLL 584
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
A++ T G T + A NGH D A +L + G L
Sbjct: 585 AA-GANVHATTATGDTALTYACENGHTDVADVLLQAGADL 623
Score = 51.2 bits (117), Expect = 4e-05
Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 2/165 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL+ A AG+ + R LL + ++AL LA + ++M R L++
Sbjct: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNE-FKESALTLACYKGHLEMVRFLLEA 423
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA + T L A +G + + A + + +P+ LAA GH +
Sbjct: 424 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 483
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
LL ++ AS+ E +G T + A+ GH + +L +G ++
Sbjct: 484 ALLIER-GASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527
Score = 50.8 bits (116), Expect = 5e-05
Identities = 41/165 (24%), Positives = 76/165 (46%), Gaps = 4/165 (2%)
Query: 70 AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNG 129
A G+ + VR+LL + T G++ L LA ++A++L+ A V+
Sbjct: 241 ACSEGDVNAVRKLLIE--GRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGI 298
Query: 130 AGQ-TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFK 188
G TPL AA G +VK +A+ + T + A G+ ++++L +
Sbjct: 299 KGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES-G 357
Query: 189 ASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEK 233
ASI + ++G T + A GH + A +L + G ++ + F++
Sbjct: 358 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKE 402
Score = 46.8 bits (106), Expect = 8e-04
Identities = 42/164 (25%), Positives = 71/164 (43%), Gaps = 7/164 (4%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGD-TALHLAARRRDVDMARILVD 119
+ G+ L LA AG + + LL+ + + GD T L AA V + ++L+
Sbjct: 265 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGIK--GDITPLMAAANGGHVKIVKLLLA 322
Query: 120 YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR--TPMHLAAENGHA 177
+ A V+A + G T L A A G +VK + + A+I D+ + TP+ A GH
Sbjct: 323 HKADVNAQSSTGNTALTYACAGGYVDVVKVL--LESGASIEDHNENGHTPLMEAGSAGHV 380
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ LL + + + + +A GH + L + G
Sbjct: 381 EVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424
Score = 42.3 bits (95), Expect = 0.018
Identities = 32/122 (26%), Positives = 46/122 (37%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T L AA+ +++ + L+ GA V AT G T L A G + A+
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 160 ADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
RTP+ AA GH ++ L K E + L +A GH +L
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGAECESEPQLIMTILSALACAGGHLAVVELLLA 685
Query: 220 KG 221
G
Sbjct: 686 HG 687
Score = 41.1 bits (92), Expect = 0.041
Identities = 20/46 (43%), Positives = 28/46 (60%)
Query: 1309 TDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
T+ + T L +A GH ++V+ LL +GA I DK G+TPL AA
Sbjct: 1079 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAA 1124
Score = 40.7 bits (91), Expect = 0.055
Identities = 20/50 (40%), Positives = 29/50 (58%)
Query: 1124 ISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAA 1173
I A+ + N T L LA GGH ++V+ L+ GAS ++ G T + LAA
Sbjct: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAA 1124
Score = 39.5 bits (88), Expect = 0.13
Identities = 22/54 (40%), Positives = 29/54 (53%), Gaps = 1/54 (1%)
Query: 1269 VQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIAST 1322
+ DA + N L LAC GGH +V LL R A + H D+ G T L +A+T
Sbjct: 1073 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEH-RDKKGFTPLILAAT 1125
Score = 33.5 bits (73), Expect = 8.3
Identities = 18/40 (45%), Positives = 24/40 (60%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAA 970
T L +AC GH +LV TLL A ++ D +G + L LAA
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAA 1124
>AB014597-1|BAA31672.2| 2486|Homo sapiens KIAA0697 protein protein.
Length = 2486
Score = 163 bits (396), Expect = 6e-39
Identities = 165/590 (27%), Positives = 254/590 (43%), Gaps = 41/590 (6%)
Query: 897 CAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVD 956
CA+ +T M A STA+ ++ NR L AC G + V LL V+
Sbjct: 94 CALDEAAAALTRMRAE-STANAGQSDNRS-------LAEACSEGDVNAVRKLLIEGRSVN 145
Query: 957 VFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGR-TALHLAAMNGYAHLVKFLI 1015
EG S L LA GY ++ LL A + + G T+L AA G+ +VK L+
Sbjct: 146 EHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITSLMAAANGGHVKIVKLLL 205
Query: 1016 RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYS 1075
H A ++ + T L A A G ++V K+LLE GA+I+ +E G P+ A +
Sbjct: 206 A-HKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHV 264
Query: 1076 EVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTP 1135
EV +L L+ + + + + +A +G ++++ L++ G T
Sbjct: 265 EVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE---AGADQEHKTDEMHTA 321
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK 1195
L A GH +V R+L+ +GA + + + LAA GH + ++
Sbjct: 322 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVN 381
Query: 1196 KLGLTPLHIAAYYGQAETVRELL---SHVPGTVKSEAPTGVSL------------VPVLG 1240
G TPL AA G E V LL +++ + T ++L + G
Sbjct: 382 DEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAG 441
Query: 1241 AESGL---TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGL 1297
A+ L TPL AA G+ +V+ LL +AG A+ G L AC GH + +
Sbjct: 442 ADIELGCSTPLMEAAQEGHLELVKYLL-AAGANVH-ATTATGDTALTYACENGHTDVADV 499
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN-ATDKNGWTPLHCAAKA 1356
LL A+L H ++ G+T L A+ GH V+ L+ +GA +N T N T L A
Sbjct: 500 LLQAGADLEHESE-GGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAG 558
Query: 1357 GHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVY 1416
GHL VV+LL GA P + AA H V+ YLL ++ L V
Sbjct: 559 GHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL--DYPNNLLSAPPPDVT 616
Query: 1417 NLMVCSKNHN---NIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKERAK 1463
L S + N +P++ +V P P + +N+ L + K +K
Sbjct: 617 QLTPPSHDLNRAPRVPVQALPMVVP-PQEPDKPPANVATTLPIRNKAASK 665
Score = 159 bits (385), Expect = 1e-37
Identities = 137/439 (31%), Positives = 210/439 (47%), Gaps = 31/439 (7%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
++VK L+ + ADV+ Q+ + TA Y G DV+ ++ + ++ N G
Sbjct: 199 KIVKLLLAHKADVNAQSSTGN-TALTYACAGGYVDVVKVLL------ESGASIEDHNENG 251
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGR-SALHLAAEHGYLQVCDALLTNKAFI 988
TPL+ A GH+++ LL N A ++ E + SAL LA G+L++ LL A
Sbjct: 252 HTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQ 311
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
K TAL A M+G+ + + L+ D A +++ ++PL LAA G +E+ LL
Sbjct: 312 EHKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVELAALL 370
Query: 1049 LELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGS 1108
+E GA+++ ++ G P+ AA+ + E+V L L Q N+ T + T +A G
Sbjct: 371 IERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGF 430
Query: 1109 VKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTA 1168
++V + L+K A +L STPL AA+ GH ++V+ L+ AGA+ G TA
Sbjct: 431 LEVADFLIK------AGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 484
Query: 1169 VHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSE 1228
+ A E+GHT+V DV+ + G TPL AA G TV+ L+S ++
Sbjct: 485 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 544
Query: 1229 APTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASN-ENGYNPLHLAC 1287
A + T L LA G+ VV LLL AD ++G L A
Sbjct: 545 ------------ANNDHTVLSLACAGGHLAVVELLLAHG---ADPTHRLKDGSTMLIEAA 589
Query: 1288 FGGHMSIVGLLLSRSAELL 1306
GGH S+V LL LL
Sbjct: 590 KGGHTSVVCYLLDYPNNLL 608
Score = 149 bits (360), Expect = 1e-34
Identities = 115/368 (31%), Positives = 184/368 (50%), Gaps = 25/368 (6%)
Query: 1054 NIDA-TDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVI 1112
+IDA T+ + A + E+VQ L++ + + K G T +AA G V V+
Sbjct: 957 DIDAQTESNHDTALTLACAGGHEELVQTLLERGAS-IEHRDKKGFTPLILAATAGHVGVV 1015
Query: 1113 EELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA 1172
E L+ D I A+++ TPL LA GG +VV +L+ GA+ N + T + LA
Sbjct: 1016 EILL--DNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLA 1073
Query: 1173 AEHGHTNVLDVMRSTNTLRISSK---KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEA 1229
A G+ N++ ++ + I+S+ KLG++PL +AA G V+ LL + + ++
Sbjct: 1074 ASGGYVNIIKILLNAGA-EINSRTGSKLGISPLMLAAMNGHTAAVKLLLD-MGSDINAQI 1131
Query: 1230 PTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLN-SAGVQADAASNENGYNPLHLACF 1288
T + T L LA + G VV LLL+ A V+ A + G PL A
Sbjct: 1132 ETNRN-----------TALTLACFQGRTEVVSLLLDRKANVEHRA---KTGLTPLMEAAS 1177
Query: 1289 GGHMSIVGLLLSRSAEL-LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGW 1347
GG+ + +LL + A++ T L IA+ GHY+ E+L+G+GA I+ +K G
Sbjct: 1178 GGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGN 1237
Query: 1348 TPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
TPL AA GHL+VV+LL ++GA + N P+ A + H V+ YL+ + + S
Sbjct: 1238 TPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPS 1297
Query: 1408 LMDDKRFV 1415
+ R++
Sbjct: 1298 DSECMRYI 1305
Score = 143 bits (346), Expect = 7e-33
Identities = 134/516 (25%), Positives = 218/516 (42%), Gaps = 23/516 (4%)
Query: 910 IAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
I +STAD +A + ++C T + + + + RS
Sbjct: 68 IGKLSTAD-GKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 126
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKK 1029
+E G + LL +N G + L LA GY L + L+ H + D
Sbjct: 127 SE-GDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGD 185
Query: 1030 QTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
T L AA G +++ KLLL A+++A G + A Y +VV++ L+ + +
Sbjct: 186 ITSLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGAS-I 244
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVR 1149
++G+T A G V+V L++ + G+ + N+ +S L LA GH ++VR
Sbjct: 245 EDHNENGHTPLMEAGSAGHVEVARLLLE-NGAGINTHSNEFKESA-LTLACYKGHLEMVR 302
Query: 1150 VLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYG 1209
L+ AGA + TA+ A GH V ++ + +PL +AA G
Sbjct: 303 FLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG 362
Query: 1210 QAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGV 1269
E L+ G SL V + G TPL AA G+E +V LLL G
Sbjct: 363 HVELAALLIER-----------GASLEEV--NDEGYTPLMEAAREGHEEMVALLLGQ-GA 408
Query: 1270 QADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMV 1329
+A + E L LAC GG + + L+ A++ + T L A+ GH ++V
Sbjct: 409 NINAQTEETQETALTLACCGGFLEVADFLIKAGADI----ELGCSTPLMEAAQEGHLELV 464
Query: 1330 EVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASE 1389
+ LL GA ++AT G T L A + GH +V +L ++GA + E+ P+ AA
Sbjct: 465 KYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARA 524
Query: 1390 NHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNH 1425
H +++L+ K + + + C+ H
Sbjct: 525 GHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGH 560
Score = 128 bits (310), Expect = 2e-28
Identities = 97/293 (33%), Positives = 148/293 (50%), Gaps = 9/293 (3%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
T L +AC GH +LV TLL A ++ D +G + L LAA G++ V + LL N A I +
Sbjct: 968 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1027
Query: 991 KA-RNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL 1049
++ R T L LA G +V+ L+ A + + TPL LAA+ G + + K+LL
Sbjct: 1028 QSERTKDTPLSLACSGGRQEVVELLLA-RGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1086
Query: 1050 ELGANIDAT--DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQG 1107
GA I++ +LG P+ AA N ++ V+L L ++ + NT +A QG
Sbjct: 1087 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1146
Query: 1108 SVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGA--SCTDENRAG 1165
+V+ L+ DR + R K TPL AA GG+A+V RVL+ GA + +
Sbjct: 1147 RTEVVSLLL--DRKANVEHRAK-TGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1203
Query: 1166 LTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
TA+ +AA+ GH +++ K G TPL +AA G + V+ L+
Sbjct: 1204 DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1256
Score = 117 bits (282), Expect = 4e-25
Identities = 100/346 (28%), Positives = 163/346 (47%), Gaps = 15/346 (4%)
Query: 881 DVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRG 940
D+ QT NH+TA G+ +++ ++ ++ ++ G+TPL++A G
Sbjct: 957 DIDAQTESNHDTALTLACAGGHEELVQTLLER------GASIEHRDKKGFTPLILAATAG 1010
Query: 941 HMQLVNTLLTNHARVDVFDVEGR-SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTAL 999
H+ +V LL N A ++ + + L LA G +V + LL A + + T L
Sbjct: 1011 HVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL 1070
Query: 1000 HLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQ--TPLHLAAASGQIEVCKLLLELGANIDA 1057
LAA GY +++K L+ + A I+ T K +PL LAA +G KLLL++G++I+A
Sbjct: 1071 SLAASGGYVNIIKILL-NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINA 1129
Query: 1058 TDELGQK-PIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
E + + A +EVV L L + N V K G T AA G +V L+
Sbjct: 1130 QIETNRNTALTLACFQGRTEVVSLLLDRKAN-VEHRAKTGLTPLMEAASGGYAEVGRVLL 1188
Query: 1117 KFDRTGVISARN-KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEH 1175
D+ ++A + T L +AA+ GH +L+ GA N+ G T + LAA
Sbjct: 1189 --DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANG 1246
Query: 1176 GHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
GH +V+ ++ ++ +TPL A G + VR L+ V
Sbjct: 1247 GHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEV 1292
Score = 111 bits (266), Expect = 3e-23
Identities = 116/433 (26%), Positives = 186/433 (42%), Gaps = 36/433 (8%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A G+V ++ LL+ G S++ + +T L A + V LL GA +
Sbjct: 218 GNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGI 277
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + +E+ L +A + LL++GA T++ T + A G++ L
Sbjct: 278 NTHSNEFKESALTLAC-YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 336
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL+ G + E+PL +A ++ LIE +G S ++
Sbjct: 337 LLDSGAQVNMPAD-------SFESPLTLAACGGHVELAALLIE-----RGAS-----LEE 379
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
V+++G + L A + EE+ V L+ GA+++ QT ETA G
Sbjct: 380 VNDEGYTPLMEAAREGHEEM---------VALLLGQGANINAQTEETQETALTLACCGGF 430
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
+V +I + AD+ + TPL+ A GH++LV LL A V G
Sbjct: 431 LEVADFLIK--AGADIELGCS-------TPLMEAAQEGHLELVKYLLAAGANVHATTATG 481
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+AL A E+G+ V D LL A + ++ GRT L AA G+ V+FLI +
Sbjct: 482 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVN 541
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
T L LA A G + V +LLL GA+ + G + AA+ ++ VV L
Sbjct: 542 RTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 601
Query: 1083 QQHPNLVMATTKD 1095
NL+ A D
Sbjct: 602 DYPNNLLSAPPPD 614
Score = 96.3 bits (229), Expect = 1e-18
Identities = 90/315 (28%), Positives = 146/315 (46%), Gaps = 17/315 (5%)
Query: 845 EDGASALHYACKVTKEEVKIPTADRQ-VVKCLIENGADVSLQTRHNHETAFHYCAIAGNN 903
E GAS H K + TA VV+ L++NGAD+ Q+ +T G
Sbjct: 987 ERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQ 1046
Query: 904 DVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVD--VFDVE 961
+V+ ++A + + +N +TPL +A G++ ++ LL A ++
Sbjct: 1047 EVVELLLARGANKE------HRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKL 1100
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGR-TALHLAAMNGYAHLVKFLIRDHNA 1020
G S L LAA +G+ LL + IN++ R TAL LA G +V L+ D A
Sbjct: 1101 GISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLL-DRKA 1159
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQK--PIHAAAQNNYSEVV 1078
++ TPL AA+ G EV ++LL+ GA+++A + + AA + +
Sbjct: 1160 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1219
Query: 1079 QLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQL 1138
+L + + + + K GNT +AA G + V++ L++ V +A N+ TPL
Sbjct: 1220 ELLIGRGAH-IDVRNKKGNTPLWLAANGGHLDVVQLLVQAG-ADVDAADNR--KITPLMA 1275
Query: 1139 AAEGGHADVVRVLVR 1153
A GH VVR LV+
Sbjct: 1276 AFRKGHVKVVRYLVK 1290
Score = 93.9 bits (223), Expect = 6e-18
Identities = 88/337 (26%), Positives = 158/337 (46%), Gaps = 32/337 (9%)
Query: 750 LLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQ 809
LL+ GA + G TP+ +AA G++ + +LL++G D +++ T +TPL
Sbjct: 985 LLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSER------TKDTPLS 1038
Query: 810 MACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADR 869
+AC ++V L+ + + +VS D A++ Y
Sbjct: 1039 LACSGGRQEVVELLLARGANKEHRNVS----DYTPLSLAASGGYV--------------- 1079
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
++K L+ GA+++ +T + A + +++ + + D++ + +
Sbjct: 1080 NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGS-DINAQIETNRN-- 1136
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
T L +AC +G ++V+ LL A V+ G + L AA GY +V LL A +N
Sbjct: 1137 -TALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1195
Query: 990 SKA--RNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKL 1047
+ + TAL +AA G+ + LI A IDV K TPL LAA G ++V +L
Sbjct: 1196 APPVPSSRDTALTIAADKGHYKFCELLI-GRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1254
Query: 1048 LLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
L++ GA++DA D P+ AA + + +VV+ +++
Sbjct: 1255 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1291
Score = 87.4 bits (207), Expect = 5e-16
Identities = 54/164 (32%), Positives = 85/164 (51%), Gaps = 2/164 (1%)
Query: 1269 VQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQM 1328
+ DA + N L LAC GGH +V LL R A + H D+ G T L +A+T GH +
Sbjct: 956 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHR-DKKGFTPLILAATAGHVGV 1014
Query: 1329 VEVLLGQGAEINA-TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAA 1387
VE+LL GA+I A +++ TPL A G VV+LL GA+ + + P+ AA
Sbjct: 1015 VEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAA 1074
Query: 1388 SENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIE 1431
S + ++++ LL+ + S K + LM+ + N + ++
Sbjct: 1075 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVK 1118
Score = 87.4 bits (207), Expect = 5e-16
Identities = 88/346 (25%), Positives = 152/346 (43%), Gaps = 29/346 (8%)
Query: 674 GHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETP 733
GH ++ TLL++G S++ +T L +A + VVE LL GAD+ + + ++TP
Sbjct: 977 GHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTP 1036
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L +A + +LL GA TP+ +AA G + + +LL G + +
Sbjct: 1037 LSLACS-GGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR 1095
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHY 853
T + G +PL +A + V+ L++ D + ++ + +AL
Sbjct: 1096 TGSKL-----GISPLMLAAMNGHTAAVKLLLDMGSDINAQ---------IETNRNTALTL 1141
Query: 854 ACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHI 913
AC + EV DR K +E+ A L E A A G V+ + A +
Sbjct: 1142 ACFQGRTEVVSLLLDR---KANVEHRAKTGLTPLM--EAASGGYAEVGR--VLLDKGADV 1194
Query: 914 STADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHG 973
+ V + + T L IA +GH + L+ A +DV + +G + L LAA G
Sbjct: 1195 NAPPVPSSRD-------TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGG 1247
Query: 974 YLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
+L V L+ A +++ T L A G+ +V++L+++ N
Sbjct: 1248 HLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVN 1293
Score = 81.0 bits (191), Expect = 4e-14
Identities = 54/153 (35%), Positives = 76/153 (49%), Gaps = 4/153 (2%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL+ A + G+ +V+ LL+A + ATT GDTAL A D+A +L+ GA ++
Sbjct: 451 PLMEAAQEGHLELVKYLLAA--GANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 508
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA-AIADNEDRTPMHLAAENGHAAIIELLA 184
+ G+TPL AA G V++ AN N D T + LA GH A++ELL
Sbjct: 509 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLL 568
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
A R KDGST++ A+ GH L
Sbjct: 569 -AHGADPTHRLKDGSTMLIEAAKGGHTSVVCYL 600
Score = 72.9 bits (171), Expect = 1e-11
Identities = 102/383 (26%), Positives = 166/383 (43%), Gaps = 51/383 (13%)
Query: 608 PTPV--PTELLPIIWKPISKDSFYTLNIDTAMELKSGFFEDRMIFWDTFFEK---YKHFD 662
P+P+ P+ +LPI + I D+ N DTA+ L + ++ T E+ +H D
Sbjct: 940 PSPIISPSAMLPI-YPAIDIDAQTESNHDTALTLACAGGHEELV--QTLLERGASIEHRD 996
Query: 663 --GARSIHTAARYGHVGIINTLLQKGESVDV-TTNDNYTALHIAVESCKPAVVETLLGYG 719
G + AA GHVG++ LL G ++ + T L +A + VVE LL G
Sbjct: 997 KKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARG 1056
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNL 777
A+ R TPL +AA +LL +GA N T G++P+ +AA G+
Sbjct: 1057 ANKEHRNVSD-YTPLSLAAS-GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHT 1114
Query: 778 ATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVK--DHKGESV 835
A + LLL+ G D + + T L +AC ++V L++ +H+ ++
Sbjct: 1115 AAVKLLLDMGSDINAQIE------TNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTG 1168
Query: 836 STAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSL-QTRHNHETAF 894
T ++A G A +V + L++ GADV+ + +TA
Sbjct: 1169 LTPLMEAA--SGGYA-------------------EVGRVLLDKGADVNAPPVPSSRDTAL 1207
Query: 895 HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
A G+ +I + DV +N G TPL +A + GH+ +V L+ A
Sbjct: 1208 TIAADKGHYKFCELLIGRGAHIDV------RNKKGNTPLWLAANGGHLDVVQLLVQAGAD 1261
Query: 955 VDVFDVEGRSALHLAAEHGYLQV 977
VD D + L A G+++V
Sbjct: 1262 VDAADNRKITPLMAAFRKGHVKV 1284
Score = 66.5 bits (155), Expect = 1e-09
Identities = 47/172 (27%), Positives = 81/172 (47%), Gaps = 3/172 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G + L+A G + +LL A A+ + A + G+TAL A VD+ ++L++ G
Sbjct: 183 KGDITSLMAAANGGHVKIVKLLLAHKAD-VNAQSSTGNTALTYACAGGYVDVVKVLLESG 241
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAAENGHAAII 180
A ++ N G TPL A + G + + A NE + + + LA GH ++
Sbjct: 242 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMV 301
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFE 232
L + A +T + T + A ++GH + A +L G ++MP FE
Sbjct: 302 RFLLEA-GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 352
Score = 65.7 bits (153), Expect = 2e-09
Identities = 50/158 (31%), Positives = 79/158 (50%), Gaps = 6/158 (3%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G++ +V+ LL + ++ G T L LAA V + IL+D GA ++A
Sbjct: 970 LTLACAGGHEELVQTLL--ERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1027
Query: 127 -TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ TPL +A + G + +V+ AN + D TP+ LAA G+ II++L +
Sbjct: 1028 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1087
Query: 186 KFKASIFERT--KDGSTLMHIASLNGHADCAMMLFKKG 221
A I RT K G + + +A++NGH +L G
Sbjct: 1088 A-GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 1124
Score = 60.1 bits (139), Expect = 8e-08
Identities = 37/121 (30%), Positives = 52/121 (42%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL+ A G + R LL + DTAL +AA + +L+ GA
Sbjct: 1168 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGA 1227
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+D N G TPL +AA G +V+ A+ ADN TP+ A GH ++
Sbjct: 1228 HIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRY 1287
Query: 183 L 183
L
Sbjct: 1288 L 1288
Score = 59.7 bits (138), Expect = 1e-07
Identities = 50/161 (31%), Positives = 78/161 (48%), Gaps = 4/161 (2%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G+ MVR LL A ++ K T TAL A V++AR+L+D GA V+
Sbjct: 289 LTLACYKGHLEMVRFLLEAGADQEHK--TDEMHTALMEACMDGHVEVARLLLDSGAQVNM 346
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ ++PL +AA G L A+ ++E TP+ AA GH ++ LL +
Sbjct: 347 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 406
Query: 187 FKASIFERTKD-GSTLMHIASLNGHADCAMMLFKKGVYLHM 226
A+I +T++ T + +A G + A L K G + +
Sbjct: 407 -GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL 446
Score = 59.3 bits (137), Expect = 1e-07
Identities = 44/162 (27%), Positives = 75/162 (46%), Gaps = 3/162 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL+LA AG+ +V E+L A+ + DT L LA ++ +L+
Sbjct: 997 KKGFTPLILAATAGHVGVV-EILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLAR 1055
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPMHLAAENGHAA 178
GA + N + TPL +AA+ G ++K G N+ +P+ LAA NGH A
Sbjct: 1056 GANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTA 1115
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
++LL D + + +T + +A G + +L +
Sbjct: 1116 AVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDR 1157
Score = 58.4 bits (135), Expect = 3e-07
Identities = 49/161 (30%), Positives = 76/161 (47%), Gaps = 4/161 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL+LA G+ + V+ LL + + T +TAL LA + ++ +L+D A
Sbjct: 1101 GISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNR-NTALTLACFQGRTEVVSLLLDRKA 1159
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPMHLAAENGHAAII 180
V+ G TPL AA+ G + + G NA + T + +AA+ GH
Sbjct: 1160 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1219
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
ELL + A I R K G+T + +A+ GH D +L + G
Sbjct: 1220 ELLIGR-GAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1259
Score = 52.8 bits (121), Expect = 1e-05
Identities = 44/168 (26%), Positives = 76/168 (45%), Gaps = 6/168 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G ++++ LL+A + + G + L LAA ++L+D G+ ++
Sbjct: 1069 PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDIN 1128
Query: 126 ATNGAGQ-TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A + T L +A +G +V +AN TP+ AA G+A + +L
Sbjct: 1129 AQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1188
Query: 185 DK---FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
DK A ++D T + IA+ GH +L +G ++ + NK
Sbjct: 1189 DKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIGRGAHIDVRNK 1234
Score = 51.6 bits (118), Expect = 3e-05
Identities = 46/160 (28%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G+ + L+ + L+ G T L AAR +M +L+ GA ++
Sbjct: 354 PLTLAACGGHVELAALLI--ERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 411
Query: 126 A-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A T +T L +A G + + ++A A I + TP+ AA+ GH +++ L
Sbjct: 412 AQTEETQETALTLACCGGFLEVADFL--IKAGADI-ELGCSTPLMEAAQEGHLELVKYLL 468
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
A++ T G T + A NGH D A +L + G L
Sbjct: 469 AA-GANVHATTATGDTALTYACENGHTDVADVLLQAGADL 507
Score = 51.2 bits (117), Expect = 4e-05
Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 2/165 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL+ A AG+ + R LL + ++AL LA + ++M R L++
Sbjct: 249 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNE-FKESALTLACYKGHLEMVRFLLEA 307
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA + T L A +G + + A + + +P+ LAA GH +
Sbjct: 308 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 367
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
LL ++ AS+ E +G T + A+ GH + +L +G ++
Sbjct: 368 ALLIER-GASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 411
Score = 47.6 bits (108), Expect = 5e-04
Identities = 40/165 (24%), Positives = 75/165 (45%), Gaps = 4/165 (2%)
Query: 70 AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNG 129
A G+ + VR+LL + T G++ L LA ++A++L+ A V+
Sbjct: 125 ACSEGDVNAVRKLLIE--GRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGI 182
Query: 130 AGQ-TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFK 188
G T L AA G +VK +A+ + T + A G+ ++++L +
Sbjct: 183 KGDITSLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES-G 241
Query: 189 ASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEK 233
ASI + ++G T + A GH + A +L + G ++ + F++
Sbjct: 242 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKE 286
Score = 47.6 bits (108), Expect = 5e-04
Identities = 42/164 (25%), Positives = 72/164 (43%), Gaps = 7/164 (4%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGD-TALHLAARRRDVDMARILVD 119
+ G+ L LA AG + + LL+ + + GD T+L AA V + ++L+
Sbjct: 149 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGIK--GDITSLMAAANGGHVKIVKLLLA 206
Query: 120 YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR--TPMHLAAENGHA 177
+ A V+A + G T L A A G +VK + + A+I D+ + TP+ A GH
Sbjct: 207 HKADVNAQSSTGNTALTYACAGGYVDVVKVL--LESGASIEDHNENGHTPLMEAGSAGHV 264
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ LL + + + + +A GH + L + G
Sbjct: 265 EVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 308
Score = 47.2 bits (107), Expect = 6e-04
Identities = 53/201 (26%), Positives = 83/201 (41%), Gaps = 13/201 (6%)
Query: 674 GHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG-GKQRET 732
G +++ LL + +V+ T L A V LL GADV+ R+T
Sbjct: 1146 GRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 1205
Query: 733 PLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLR 792
L IAA C L L+ GA + + G TP+ +AA G+L + LL++ G D
Sbjct: 1206 ALTIAADKGHYKFCEL-LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA 1264
Query: 793 KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALH 852
I TPL A R +VR+L++ V +S +I + + +
Sbjct: 1265 ADNRKI-------TPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITD---KEML 1314
Query: 853 YACKVTKEEVKIPTADRQVVK 873
C + E + + DRQ +
Sbjct: 1315 KKCHLCMESI-VQAKDRQAAE 1334
Score = 46.8 bits (106), Expect = 8e-04
Identities = 38/146 (26%), Positives = 68/146 (46%), Gaps = 3/146 (2%)
Query: 82 LLSAQTAEQLKATTPAG-DTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAA 140
+L A + A T + DTAL LA ++ + L++ GA ++ + G TPL +AA
Sbjct: 949 MLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAAT 1008
Query: 141 EGDEPLVKYFYGVRAN-AAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGS 199
G +V+ A+ A ++ TP+ LA G ++ELL + A+ R
Sbjct: 1009 AGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLAR-GANKEHRNVSDY 1067
Query: 200 TLMHIASLNGHADCAMMLFKKGVYLH 225
T + +A+ G+ + +L G ++
Sbjct: 1068 TPLSLAASGGYVNIIKILLNAGAEIN 1093
Score = 45.6 bits (103), Expect = 0.002
Identities = 33/123 (26%), Positives = 51/123 (41%), Gaps = 2/123 (1%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T L AA+ +++ + L+ GA V AT G T L A G + A+
Sbjct: 450 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 509
Query: 160 ADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGS-TLMHIASLNGHADCAMMLF 218
RTP+ AA GH ++ L K A++ T + T++ +A GH +L
Sbjct: 510 ESEGGRTPLMKAARAGHVCTVQFLISK-GANVNRTTANNDHTVLSLACAGGHLAVVELLL 568
Query: 219 KKG 221
G
Sbjct: 569 AHG 571
Score = 44.0 bits (99), Expect = 0.006
Identities = 36/115 (31%), Positives = 55/115 (47%), Gaps = 6/115 (5%)
Query: 111 VDMARILVDYGAV-VDA-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPM 168
+ + +L Y A+ +DA T T L +A A G E LV+ A+ D + TP+
Sbjct: 944 ISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPL 1003
Query: 169 HLAAENGHAAIIELLADKFK--ASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LAA GH ++E+L D + ERTKD T + +A G + +L +G
Sbjct: 1004 ILAATAGHVGVVEILLDNGADIEAQSERTKD--TPLSLACSGGRQEVVELLLARG 1056
Score = 41.9 bits (94), Expect = 0.024
Identities = 47/165 (28%), Positives = 76/165 (46%), Gaps = 15/165 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY-TALHIAVESCKPAVVETLLGYGA 720
+G + AAR GH ++ LL +G +++ T + TAL +A V + L+ GA
Sbjct: 383 EGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA 442
Query: 721 DVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
D+ + TPL AA+ +G + LL +GA + T G T + A + G+
Sbjct: 443 DIEL----GCSTPLMEAAQ--EGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDV 496
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLI 824
+LL+ G D +++ G TPL A R+ V+ LI
Sbjct: 497 ADVLLQAGADLEHESE-------GGRTPLMKAARAGHVCTVQFLI 534
>BC007747-1|AAH07747.2| 830|Homo sapiens ANKRD17 protein protein.
Length = 830
Score = 162 bits (394), Expect = 1e-38
Identities = 165/590 (27%), Positives = 253/590 (42%), Gaps = 41/590 (6%)
Query: 897 CAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVD 956
CA+ +T M A STA+ ++ NR L AC G + V LL V+
Sbjct: 30 CALDEAAAALTRMRAE-STANAGQSDNRS-------LAEACSEGDVNAVRKLLIEGRSVN 81
Query: 957 VFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGR-TALHLAAMNGYAHLVKFLI 1015
EG S L LA GY ++ LL A + + G T L AA G+ +VK L+
Sbjct: 82 EHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLL 141
Query: 1016 RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYS 1075
H A ++ + T L A A G ++V K+LLE GA+I+ +E G P+ A +
Sbjct: 142 A-HKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHV 200
Query: 1076 EVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTP 1135
EV +L L+ + + + + +A +G ++++ L++ G T
Sbjct: 201 EVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE---AGADQEHKTDEMHTA 257
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK 1195
L A GH +V R+L+ +GA + + + LAA GH + ++
Sbjct: 258 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVN 317
Query: 1196 KLGLTPLHIAAYYGQAETVRELL---SHVPGTVKSEAPTGVSL------------VPVLG 1240
G TPL AA G E V LL +++ + T ++L + G
Sbjct: 318 DEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAG 377
Query: 1241 AESGL---TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGL 1297
A+ L TPL AA G+ +V+ LL +AG A+ G L AC GH + +
Sbjct: 378 ADIELGCSTPLMEAAQEGHLELVKYLL-AAGANVH-ATTATGDTALTYACENGHTDVADV 435
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN-ATDKNGWTPLHCAAKA 1356
LL A+L H ++ G+T L A+ GH V+ L+ +GA +N T N T L A
Sbjct: 436 LLQAGADLEHESE-GGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAG 494
Query: 1357 GHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVY 1416
GHL VV+LL GA P + AA H V+ YLL ++ L V
Sbjct: 495 GHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL--DYPNNLLSAPPPDVT 552
Query: 1417 NLMVCSKNHN---NIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKERAK 1463
L S + N +P++ +V P P + +N+ L + K +K
Sbjct: 553 QLTPPSHDLNRAPRVPVQALPMVVP-PQEPDKPPANVATTLPIRNKAASK 601
Score = 159 bits (385), Expect = 1e-37
Identities = 137/439 (31%), Positives = 210/439 (47%), Gaps = 31/439 (7%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
++VK L+ + ADV+ Q+ + TA Y G DV+ ++ + ++ N G
Sbjct: 135 KIVKLLLAHKADVNAQSSTGN-TALTYACAGGYVDVVKVLL------ESGASIEDHNENG 187
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGR-SALHLAAEHGYLQVCDALLTNKAFI 988
TPL+ A GH+++ LL N A ++ E + SAL LA G+L++ LL A
Sbjct: 188 HTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQ 247
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
K TAL A M+G+ + + L+ D A +++ ++PL LAA G +E+ LL
Sbjct: 248 EHKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVELAALL 306
Query: 1049 LELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGS 1108
+E GA+++ ++ G P+ AA+ + E+V L L Q N+ T + T +A G
Sbjct: 307 IERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGF 366
Query: 1109 VKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTA 1168
++V + L+K A +L STPL AA+ GH ++V+ L+ AGA+ G TA
Sbjct: 367 LEVADFLIK------AGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 420
Query: 1169 VHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSE 1228
+ A E+GHT+V DV+ + G TPL AA G TV+ L+S ++
Sbjct: 421 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 480
Query: 1229 APTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASN-ENGYNPLHLAC 1287
A + T L LA G+ VV LLL AD ++G L A
Sbjct: 481 ------------ANNDHTVLSLACAGGHLAVVELLLAHG---ADPTHRLKDGSTMLIEAA 525
Query: 1288 FGGHMSIVGLLLSRSAELL 1306
GGH S+V LL LL
Sbjct: 526 KGGHTSVVCYLLDYPNNLL 544
Score = 146 bits (354), Expect = 7e-34
Identities = 135/516 (26%), Positives = 219/516 (42%), Gaps = 23/516 (4%)
Query: 910 IAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
I +STAD +A + ++C T + + + + RS
Sbjct: 4 IGKLSTAD-GKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 62
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKK 1029
+E G + LL +N G + L LA GY L + L+ H + D
Sbjct: 63 SE-GDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGD 121
Query: 1030 QTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
TPL AA G +++ KLLL A+++A G + A Y +VV++ L+ + +
Sbjct: 122 ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGAS-I 180
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVR 1149
++G+T A G V+V L++ + G+ + N+ +S L LA GH ++VR
Sbjct: 181 EDHNENGHTPLMEAGSAGHVEVARLLLE-NGAGINTHSNEFKESA-LTLACYKGHLEMVR 238
Query: 1150 VLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYG 1209
L+ AGA + TA+ A GH V ++ + +PL +AA G
Sbjct: 239 FLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG 298
Query: 1210 QAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGV 1269
E L+ G SL V + G TPL AA G+E +V LLL G
Sbjct: 299 HVELAALLIER-----------GASLEEV--NDEGYTPLMEAAREGHEEMVALLLGQ-GA 344
Query: 1270 QADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMV 1329
+A + E L LAC GG + + L+ A++ + T L A+ GH ++V
Sbjct: 345 NINAQTEETQETALTLACCGGFLEVADFLIKAGADI----ELGCSTPLMEAAQEGHLELV 400
Query: 1330 EVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASE 1389
+ LL GA ++AT G T L A + GH +V +L ++GA + E+ P+ AA
Sbjct: 401 KYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARA 460
Query: 1390 NHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNH 1425
H +++L+ K + + + C+ H
Sbjct: 461 GHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGH 496
Score = 111 bits (266), Expect = 3e-23
Identities = 116/433 (26%), Positives = 186/433 (42%), Gaps = 36/433 (8%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A G+V ++ LL+ G S++ + +T L A + V LL GA +
Sbjct: 154 GNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGI 213
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + +E+ L +A + LL++GA T++ T + A G++ L
Sbjct: 214 NTHSNEFKESALTLAC-YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 272
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL+ G + E+PL +A ++ LIE +G S ++
Sbjct: 273 LLDSGAQVNMPAD-------SFESPLTLAACGGHVELAALLIE-----RGAS-----LEE 315
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
V+++G + L A + EE+ V L+ GA+++ QT ETA G
Sbjct: 316 VNDEGYTPLMEAAREGHEEM---------VALLLGQGANINAQTEETQETALTLACCGGF 366
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
+V +I + AD+ + TPL+ A GH++LV LL A V G
Sbjct: 367 LEVADFLIK--AGADIELGCS-------TPLMEAAQEGHLELVKYLLAAGANVHATTATG 417
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+AL A E+G+ V D LL A + ++ GRT L AA G+ V+FLI +
Sbjct: 418 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVN 477
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
T L LA A G + V +LLL GA+ + G + AA+ ++ VV L
Sbjct: 478 RTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 537
Query: 1083 QQHPNLVMATTKD 1095
NL+ A D
Sbjct: 538 DYPNNLLSAPPPD 550
Score = 81.0 bits (191), Expect = 4e-14
Identities = 54/153 (35%), Positives = 76/153 (49%), Gaps = 4/153 (2%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL+ A + G+ +V+ LL+A + ATT GDTAL A D+A +L+ GA ++
Sbjct: 387 PLMEAAQEGHLELVKYLLAA--GANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 444
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA-AIADNEDRTPMHLAAENGHAAIIELLA 184
+ G+TPL AA G V++ AN N D T + LA GH A++ELL
Sbjct: 445 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLL 504
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
A R KDGST++ A+ GH L
Sbjct: 505 -AHGADPTHRLKDGSTMLIEAAKGGHTSVVCYL 536
Score = 66.1 bits (154), Expect = 1e-09
Identities = 48/168 (28%), Positives = 81/168 (48%), Gaps = 4/168 (2%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL+ A G+ +V+ LL A A+ + A + G+TAL A VD+ ++L++ GA ++
Sbjct: 124 PLMAAANGGHVKIVK-LLLAHKAD-VNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 181
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAAENGHAAIIELLA 184
N G TPL A + G + + A NE + + + LA GH ++ L
Sbjct: 182 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 241
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFE 232
+ A +T + T + A ++GH + A +L G ++MP FE
Sbjct: 242 EA-GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 288
Score = 59.7 bits (138), Expect = 1e-07
Identities = 50/161 (31%), Positives = 78/161 (48%), Gaps = 4/161 (2%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G+ MVR LL A ++ K T TAL A V++AR+L+D GA V+
Sbjct: 225 LTLACYKGHLEMVRFLLEAGADQEHK--TDEMHTALMEACMDGHVEVARLLLDSGAQVNM 282
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ ++PL +AA G L A+ ++E TP+ AA GH ++ LL +
Sbjct: 283 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 342
Query: 187 FKASIFERTKD-GSTLMHIASLNGHADCAMMLFKKGVYLHM 226
A+I +T++ T + +A G + A L K G + +
Sbjct: 343 -GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL 382
Score = 51.6 bits (118), Expect = 3e-05
Identities = 46/160 (28%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G+ + L+ + L+ G T L AAR +M +L+ GA ++
Sbjct: 290 PLTLAACGGHVELAALLI--ERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 347
Query: 126 A-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A T +T L +A G + + ++A A I + TP+ AA+ GH +++ L
Sbjct: 348 AQTEETQETALTLACCGGFLEVADFL--IKAGADI-ELGCSTPLMEAAQEGHLELVKYLL 404
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
A++ T G T + A NGH D A +L + G L
Sbjct: 405 AA-GANVHATTATGDTALTYACENGHTDVADVLLQAGADL 443
Score = 51.2 bits (117), Expect = 4e-05
Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 2/165 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL+ A AG+ + R LL + ++AL LA + ++M R L++
Sbjct: 185 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNE-FKESALTLACYKGHLEMVRFLLEA 243
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA + T L A +G + + A + + +P+ LAA GH +
Sbjct: 244 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 303
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
LL ++ AS+ E +G T + A+ GH + +L +G ++
Sbjct: 304 ALLIER-GASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 347
Score = 50.8 bits (116), Expect = 5e-05
Identities = 41/165 (24%), Positives = 76/165 (46%), Gaps = 4/165 (2%)
Query: 70 AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNG 129
A G+ + VR+LL + T G++ L LA ++A++L+ A V+
Sbjct: 61 ACSEGDVNAVRKLLIE--GRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGI 118
Query: 130 AGQ-TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFK 188
G TPL AA G +VK +A+ + T + A G+ ++++L +
Sbjct: 119 KGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES-G 177
Query: 189 ASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEK 233
ASI + ++G T + A GH + A +L + G ++ + F++
Sbjct: 178 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKE 222
Score = 46.8 bits (106), Expect = 8e-04
Identities = 42/164 (25%), Positives = 71/164 (43%), Gaps = 7/164 (4%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGD-TALHLAARRRDVDMARILVD 119
+ G+ L LA AG + + LL+ + + GD T L AA V + ++L+
Sbjct: 85 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGIK--GDITPLMAAANGGHVKIVKLLLA 142
Query: 120 YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR--TPMHLAAENGHA 177
+ A V+A + G T L A A G +VK + + A+I D+ + TP+ A GH
Sbjct: 143 HKADVNAQSSTGNTALTYACAGGYVDVVKVL--LESGASIEDHNENGHTPLMEAGSAGHV 200
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ LL + + + + +A GH + L + G
Sbjct: 201 EVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 244
Score = 45.6 bits (103), Expect = 0.002
Identities = 33/123 (26%), Positives = 51/123 (41%), Gaps = 2/123 (1%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T L AA+ +++ + L+ GA V AT G T L A G + A+
Sbjct: 386 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 445
Query: 160 ADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGS-TLMHIASLNGHADCAMMLF 218
RTP+ AA GH ++ L K A++ T + T++ +A GH +L
Sbjct: 446 ESEGGRTPLMKAARAGHVCTVQFLISK-GANVNRTTANNDHTVLSLACAGGHLAVVELLL 504
Query: 219 KKG 221
G
Sbjct: 505 AHG 507
Score = 41.9 bits (94), Expect = 0.024
Identities = 47/165 (28%), Positives = 76/165 (46%), Gaps = 15/165 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY-TALHIAVESCKPAVVETLLGYGA 720
+G + AAR GH ++ LL +G +++ T + TAL +A V + L+ GA
Sbjct: 319 EGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA 378
Query: 721 DVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
D+ + TPL AA+ +G + LL +GA + T G T + A + G+
Sbjct: 379 DIEL----GCSTPLMEAAQ--EGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDV 432
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLI 824
+LL+ G D +++ G TPL A R+ V+ LI
Sbjct: 433 ADVLLQAGADLEHESE-------GGRTPLMKAARAGHVCTVQFLI 470
>BC004173-1|AAH04173.1| 1500|Homo sapiens ANKRD17 protein protein.
Length = 1500
Score = 162 bits (394), Expect = 1e-38
Identities = 165/590 (27%), Positives = 253/590 (42%), Gaps = 41/590 (6%)
Query: 897 CAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVD 956
CA+ +T M A STA+ ++ NR L AC G + V LL V+
Sbjct: 210 CALDEAAAALTRMRAE-STANAGQSDNRS-------LAEACSEGDVNAVRKLLIEGRSVN 261
Query: 957 VFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGR-TALHLAAMNGYAHLVKFLI 1015
EG S L LA GY ++ LL A + + G T L AA G+ +VK L+
Sbjct: 262 EHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLL 321
Query: 1016 RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYS 1075
H A ++ + T L A A G ++V K+LLE GA+I+ +E G P+ A +
Sbjct: 322 A-HKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHV 380
Query: 1076 EVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTP 1135
EV +L L+ + + + + +A +G ++++ L++ G T
Sbjct: 381 EVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE---AGADQEHKTDEMHTA 437
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK 1195
L A GH +V R+L+ +GA + + + LAA GH + ++
Sbjct: 438 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVN 497
Query: 1196 KLGLTPLHIAAYYGQAETVRELL---SHVPGTVKSEAPTGVSL------------VPVLG 1240
G TPL AA G E V LL +++ + T ++L + G
Sbjct: 498 DEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAG 557
Query: 1241 AESGL---TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGL 1297
A+ L TPL AA G+ +V+ LL +AG A+ G L AC GH + +
Sbjct: 558 ADIELGCSTPLMEAAQEGHLELVKYLL-AAGANVH-ATTATGDTALTYACENGHTDVADV 615
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN-ATDKNGWTPLHCAAKA 1356
LL A+L H ++ G+T L A+ GH V+ L+ +GA +N T N T L A
Sbjct: 616 LLQAGADLEHESE-GGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAG 674
Query: 1357 GHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVY 1416
GHL VV+LL GA P + AA H V+ YLL ++ L V
Sbjct: 675 GHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL--DYPNNLLSAPPPDVT 732
Query: 1417 NLMVCSKNHN---NIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKERAK 1463
L S + N +P++ +V P P + +N+ L + K +K
Sbjct: 733 QLTPPSHDLNRAPRVPVQALPMVVP-PQEPDKPPANVATTLPIRNKAASK 781
Score = 159 bits (385), Expect = 1e-37
Identities = 137/439 (31%), Positives = 210/439 (47%), Gaps = 31/439 (7%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
++VK L+ + ADV+ Q+ + TA Y G DV+ ++ + ++ N G
Sbjct: 315 KIVKLLLAHKADVNAQSSTGN-TALTYACAGGYVDVVKVLL------ESGASIEDHNENG 367
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGR-SALHLAAEHGYLQVCDALLTNKAFI 988
TPL+ A GH+++ LL N A ++ E + SAL LA G+L++ LL A
Sbjct: 368 HTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQ 427
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
K TAL A M+G+ + + L+ D A +++ ++PL LAA G +E+ LL
Sbjct: 428 EHKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVELAALL 486
Query: 1049 LELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGS 1108
+E GA+++ ++ G P+ AA+ + E+V L L Q N+ T + T +A G
Sbjct: 487 IERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGF 546
Query: 1109 VKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTA 1168
++V + L+K A +L STPL AA+ GH ++V+ L+ AGA+ G TA
Sbjct: 547 LEVADFLIK------AGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600
Query: 1169 VHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSE 1228
+ A E+GHT+V DV+ + G TPL AA G TV+ L+S ++
Sbjct: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660
Query: 1229 APTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASN-ENGYNPLHLAC 1287
A + T L LA G+ VV LLL AD ++G L A
Sbjct: 661 ------------ANNDHTVLSLACAGGHLAVVELLLAHG---ADPTHRLKDGSTMLIEAA 705
Query: 1288 FGGHMSIVGLLLSRSAELL 1306
GGH S+V LL LL
Sbjct: 706 KGGHTSVVCYLLDYPNNLL 724
Score = 149 bits (360), Expect = 1e-34
Identities = 115/368 (31%), Positives = 184/368 (50%), Gaps = 25/368 (6%)
Query: 1054 NIDA-TDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVI 1112
+IDA T+ + A + E+VQ L++ + + K G T +AA G V V+
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGAS-IEHRDKKGFTPLILAATAGHVGVV 1132
Query: 1113 EELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA 1172
E L+ D I A+++ TPL LA GG +VV +L+ GA+ N + T + LA
Sbjct: 1133 EILL--DNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLA 1190
Query: 1173 AEHGHTNVLDVMRSTNTLRISSK---KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEA 1229
A G+ N++ ++ + I+S+ KLG++PL +AA G V+ LL + + ++
Sbjct: 1191 ASGGYVNIIKILLNAGA-EINSRTGSKLGISPLMLAAMNGHTAAVKLLLD-MGSDINAQI 1248
Query: 1230 PTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLN-SAGVQADAASNENGYNPLHLACF 1288
T + T L LA + G VV LLL+ A V+ A + G PL A
Sbjct: 1249 ETNRN-----------TALTLACFQGRTEVVSLLLDRKANVEHRA---KTGLTPLMEAAS 1294
Query: 1289 GGHMSIVGLLLSRSAEL-LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGW 1347
GG+ + +LL + A++ T L IA+ GHY+ E+L+G+GA I+ +K G
Sbjct: 1295 GGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGN 1354
Query: 1348 TPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
TPL AA GHL+VV+LL ++GA + N P+ A + H V+ YL+ + + S
Sbjct: 1355 TPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPS 1414
Query: 1408 LMDDKRFV 1415
+ R++
Sbjct: 1415 DSECMRYI 1422
Score = 146 bits (354), Expect = 7e-34
Identities = 135/516 (26%), Positives = 219/516 (42%), Gaps = 23/516 (4%)
Query: 910 IAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
I +STAD +A + ++C T + + + + RS
Sbjct: 184 IGKLSTAD-GKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 242
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKK 1029
+E G + LL +N G + L LA GY L + L+ H + D
Sbjct: 243 SE-GDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGD 301
Query: 1030 QTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
TPL AA G +++ KLLL A+++A G + A Y +VV++ L+ + +
Sbjct: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGAS-I 360
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVR 1149
++G+T A G V+V L++ + G+ + N+ +S L LA GH ++VR
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLE-NGAGINTHSNEFKESA-LTLACYKGHLEMVR 418
Query: 1150 VLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYG 1209
L+ AGA + TA+ A GH V ++ + +PL +AA G
Sbjct: 419 FLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG 478
Query: 1210 QAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGV 1269
E L+ G SL V + G TPL AA G+E +V LLL G
Sbjct: 479 HVELAALLIER-----------GASLEEV--NDEGYTPLMEAAREGHEEMVALLLGQ-GA 524
Query: 1270 QADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMV 1329
+A + E L LAC GG + + L+ A++ + T L A+ GH ++V
Sbjct: 525 NINAQTEETQETALTLACCGGFLEVADFLIKAGADI----ELGCSTPLMEAAQEGHLELV 580
Query: 1330 EVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASE 1389
+ LL GA ++AT G T L A + GH +V +L ++GA + E+ P+ AA
Sbjct: 581 KYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARA 640
Query: 1390 NHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNH 1425
H +++L+ K + + + C+ H
Sbjct: 641 GHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGH 676
Score = 128 bits (310), Expect = 2e-28
Identities = 97/293 (33%), Positives = 148/293 (50%), Gaps = 9/293 (3%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
T L +AC GH +LV TLL A ++ D +G + L LAA G++ V + LL N A I +
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
Query: 991 KA-RNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL 1049
++ R T L LA G +V+ L+ A + + TPL LAA+ G + + K+LL
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLA-RGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1203
Query: 1050 ELGANIDAT--DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQG 1107
GA I++ +LG P+ AA N ++ V+L L ++ + NT +A QG
Sbjct: 1204 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1263
Query: 1108 SVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGA--SCTDENRAG 1165
+V+ L+ DR + R K TPL AA GG+A+V RVL+ GA + +
Sbjct: 1264 RTEVVSLLL--DRKANVEHRAK-TGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1320
Query: 1166 LTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
TA+ +AA+ GH +++ K G TPL +AA G + V+ L+
Sbjct: 1321 DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1373
Score = 117 bits (282), Expect = 4e-25
Identities = 100/346 (28%), Positives = 163/346 (47%), Gaps = 15/346 (4%)
Query: 881 DVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRG 940
D+ QT NH+TA G+ +++ ++ ++ ++ G+TPL++A G
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLER------GASIEHRDKKGFTPLILAATAG 1127
Query: 941 HMQLVNTLLTNHARVDVFDVEGR-SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTAL 999
H+ +V LL N A ++ + + L LA G +V + LL A + + T L
Sbjct: 1128 HVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL 1187
Query: 1000 HLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQ--TPLHLAAASGQIEVCKLLLELGANIDA 1057
LAA GY +++K L+ + A I+ T K +PL LAA +G KLLL++G++I+A
Sbjct: 1188 SLAASGGYVNIIKILL-NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINA 1246
Query: 1058 TDELGQK-PIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
E + + A +EVV L L + N V K G T AA G +V L+
Sbjct: 1247 QIETNRNTALTLACFQGRTEVVSLLLDRKAN-VEHRAKTGLTPLMEAASGGYAEVGRVLL 1305
Query: 1117 KFDRTGVISARN-KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEH 1175
D+ ++A + T L +AA+ GH +L+ GA N+ G T + LAA
Sbjct: 1306 --DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANG 1363
Query: 1176 GHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
GH +V+ ++ ++ +TPL A G + VR L+ V
Sbjct: 1364 GHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEV 1409
Score = 111 bits (266), Expect = 3e-23
Identities = 116/433 (26%), Positives = 186/433 (42%), Gaps = 36/433 (8%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A G+V ++ LL+ G S++ + +T L A + V LL GA +
Sbjct: 334 GNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGI 393
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + +E+ L +A + LL++GA T++ T + A G++ L
Sbjct: 394 NTHSNEFKESALTLAC-YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 452
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL+ G + E+PL +A ++ LIE +G S ++
Sbjct: 453 LLDSGAQVNMPAD-------SFESPLTLAACGGHVELAALLIE-----RGAS-----LEE 495
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
V+++G + L A + EE+ V L+ GA+++ QT ETA G
Sbjct: 496 VNDEGYTPLMEAAREGHEEM---------VALLLGQGANINAQTEETQETALTLACCGGF 546
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
+V +I + AD+ + TPL+ A GH++LV LL A V G
Sbjct: 547 LEVADFLIK--AGADIELGCS-------TPLMEAAQEGHLELVKYLLAAGANVHATTATG 597
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+AL A E+G+ V D LL A + ++ GRT L AA G+ V+FLI +
Sbjct: 598 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVN 657
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
T L LA A G + V +LLL GA+ + G + AA+ ++ VV L
Sbjct: 658 RTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
Query: 1083 QQHPNLVMATTKD 1095
NL+ A D
Sbjct: 718 DYPNNLLSAPPPD 730
Score = 96.3 bits (229), Expect = 1e-18
Identities = 90/315 (28%), Positives = 146/315 (46%), Gaps = 17/315 (5%)
Query: 845 EDGASALHYACKVTKEEVKIPTADRQ-VVKCLIENGADVSLQTRHNHETAFHYCAIAGNN 903
E GAS H K + TA VV+ L++NGAD+ Q+ +T G
Sbjct: 1104 ERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQ 1163
Query: 904 DVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVD--VFDVE 961
+V+ ++A + + +N +TPL +A G++ ++ LL A ++
Sbjct: 1164 EVVELLLARGANKE------HRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKL 1217
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGR-TALHLAAMNGYAHLVKFLIRDHNA 1020
G S L LAA +G+ LL + IN++ R TAL LA G +V L+ D A
Sbjct: 1218 GISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLL-DRKA 1276
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQK--PIHAAAQNNYSEVV 1078
++ TPL AA+ G EV ++LL+ GA+++A + + AA + +
Sbjct: 1277 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1336
Query: 1079 QLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQL 1138
+L + + + + K GNT +AA G + V++ L++ V +A N+ TPL
Sbjct: 1337 ELLIGRGAH-IDVRNKKGNTPLWLAANGGHLDVVQLLVQAG-ADVDAADNR--KITPLMA 1392
Query: 1139 AAEGGHADVVRVLVR 1153
A GH VVR LV+
Sbjct: 1393 AFRKGHVKVVRYLVK 1407
Score = 93.9 bits (223), Expect = 6e-18
Identities = 88/337 (26%), Positives = 158/337 (46%), Gaps = 32/337 (9%)
Query: 750 LLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQ 809
LL+ GA + G TP+ +AA G++ + +LL++G D +++ T +TPL
Sbjct: 1102 LLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSER------TKDTPLS 1155
Query: 810 MACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADR 869
+AC ++V L+ + + +VS D A++ Y
Sbjct: 1156 LACSGGRQEVVELLLARGANKEHRNVS----DYTPLSLAASGGYV--------------- 1196
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
++K L+ GA+++ +T + A + +++ + + D++ + +
Sbjct: 1197 NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGS-DINAQIETNRN-- 1253
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
T L +AC +G ++V+ LL A V+ G + L AA GY +V LL A +N
Sbjct: 1254 -TALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1312
Query: 990 SKA--RNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKL 1047
+ + TAL +AA G+ + LI A IDV K TPL LAA G ++V +L
Sbjct: 1313 APPVPSSRDTALTIAADKGHYKFCELLI-GRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1371
Query: 1048 LLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
L++ GA++DA D P+ AA + + +VV+ +++
Sbjct: 1372 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408
Score = 87.4 bits (207), Expect = 5e-16
Identities = 54/164 (32%), Positives = 85/164 (51%), Gaps = 2/164 (1%)
Query: 1269 VQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQM 1328
+ DA + N L LAC GGH +V LL R A + H D+ G T L +A+T GH +
Sbjct: 1073 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHR-DKKGFTPLILAATAGHVGV 1131
Query: 1329 VEVLLGQGAEINA-TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAA 1387
VE+LL GA+I A +++ TPL A G VV+LL GA+ + + P+ AA
Sbjct: 1132 VEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAA 1191
Query: 1388 SENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIE 1431
S + ++++ LL+ + S K + LM+ + N + ++
Sbjct: 1192 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVK 1235
Score = 87.4 bits (207), Expect = 5e-16
Identities = 88/346 (25%), Positives = 152/346 (43%), Gaps = 29/346 (8%)
Query: 674 GHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETP 733
GH ++ TLL++G S++ +T L +A + VVE LL GAD+ + + ++TP
Sbjct: 1094 GHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTP 1153
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L +A + +LL GA TP+ +AA G + + +LL G + +
Sbjct: 1154 LSLACS-GGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR 1212
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHY 853
T + G +PL +A + V+ L++ D + ++ + +AL
Sbjct: 1213 TGSKL-----GISPLMLAAMNGHTAAVKLLLDMGSDINAQ---------IETNRNTALTL 1258
Query: 854 ACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHI 913
AC + EV DR K +E+ A L E A A G V+ + A +
Sbjct: 1259 ACFQGRTEVVSLLLDR---KANVEHRAKTGLTPLM--EAASGGYAEVGR--VLLDKGADV 1311
Query: 914 STADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHG 973
+ V + + T L IA +GH + L+ A +DV + +G + L LAA G
Sbjct: 1312 NAPPVPSSRD-------TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGG 1364
Query: 974 YLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
+L V L+ A +++ T L A G+ +V++L+++ N
Sbjct: 1365 HLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVN 1410
Score = 81.0 bits (191), Expect = 4e-14
Identities = 54/153 (35%), Positives = 76/153 (49%), Gaps = 4/153 (2%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL+ A + G+ +V+ LL+A + ATT GDTAL A D+A +L+ GA ++
Sbjct: 567 PLMEAAQEGHLELVKYLLAA--GANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA-AIADNEDRTPMHLAAENGHAAIIELLA 184
+ G+TPL AA G V++ AN N D T + LA GH A++ELL
Sbjct: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLL 684
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
A R KDGST++ A+ GH L
Sbjct: 685 -AHGADPTHRLKDGSTMLIEAAKGGHTSVVCYL 716
Score = 72.9 bits (171), Expect = 1e-11
Identities = 102/383 (26%), Positives = 166/383 (43%), Gaps = 51/383 (13%)
Query: 608 PTPV--PTELLPIIWKPISKDSFYTLNIDTAMELKSGFFEDRMIFWDTFFEK---YKHFD 662
P+P+ P+ +LPI + I D+ N DTA+ L + ++ T E+ +H D
Sbjct: 1057 PSPIISPSAMLPI-YPAIDIDAQTESNHDTALTLACAGGHEELV--QTLLERGASIEHRD 1113
Query: 663 --GARSIHTAARYGHVGIINTLLQKGESVDV-TTNDNYTALHIAVESCKPAVVETLLGYG 719
G + AA GHVG++ LL G ++ + T L +A + VVE LL G
Sbjct: 1114 KKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARG 1173
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNL 777
A+ R TPL +AA +LL +GA N T G++P+ +AA G+
Sbjct: 1174 ANKEHRNVSD-YTPLSLAAS-GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHT 1231
Query: 778 ATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVK--DHKGESV 835
A + LLL+ G D + + T L +AC ++V L++ +H+ ++
Sbjct: 1232 AAVKLLLDMGSDINAQIE------TNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTG 1285
Query: 836 STAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSL-QTRHNHETAF 894
T ++A G A +V + L++ GADV+ + +TA
Sbjct: 1286 LTPLMEAA--SGGYA-------------------EVGRVLLDKGADVNAPPVPSSRDTAL 1324
Query: 895 HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
A G+ +I + DV +N G TPL +A + GH+ +V L+ A
Sbjct: 1325 TIAADKGHYKFCELLIGRGAHIDV------RNKKGNTPLWLAANGGHLDVVQLLVQAGAD 1378
Query: 955 VDVFDVEGRSALHLAAEHGYLQV 977
VD D + L A G+++V
Sbjct: 1379 VDAADNRKITPLMAAFRKGHVKV 1401
Score = 66.1 bits (154), Expect = 1e-09
Identities = 48/168 (28%), Positives = 81/168 (48%), Gaps = 4/168 (2%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL+ A G+ +V+ LL A A+ + A + G+TAL A VD+ ++L++ GA ++
Sbjct: 304 PLMAAANGGHVKIVK-LLLAHKAD-VNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 361
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAAENGHAAIIELLA 184
N G TPL A + G + + A NE + + + LA GH ++ L
Sbjct: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 421
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFE 232
+ A +T + T + A ++GH + A +L G ++MP FE
Sbjct: 422 EA-GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 468
Score = 65.7 bits (153), Expect = 2e-09
Identities = 50/158 (31%), Positives = 79/158 (50%), Gaps = 6/158 (3%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G++ +V+ LL + ++ G T L LAA V + IL+D GA ++A
Sbjct: 1087 LTLACAGGHEELVQTLL--ERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
Query: 127 -TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ TPL +A + G + +V+ AN + D TP+ LAA G+ II++L +
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1204
Query: 186 KFKASIFERT--KDGSTLMHIASLNGHADCAMMLFKKG 221
A I RT K G + + +A++NGH +L G
Sbjct: 1205 A-GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 1241
Score = 60.1 bits (139), Expect = 8e-08
Identities = 37/121 (30%), Positives = 52/121 (42%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL+ A G + R LL + DTAL +AA + +L+ GA
Sbjct: 1285 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGA 1344
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+D N G TPL +AA G +V+ A+ ADN TP+ A GH ++
Sbjct: 1345 HIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRY 1404
Query: 183 L 183
L
Sbjct: 1405 L 1405
Score = 59.7 bits (138), Expect = 1e-07
Identities = 50/161 (31%), Positives = 78/161 (48%), Gaps = 4/161 (2%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G+ MVR LL A ++ K T TAL A V++AR+L+D GA V+
Sbjct: 405 LTLACYKGHLEMVRFLLEAGADQEHK--TDEMHTALMEACMDGHVEVARLLLDSGAQVNM 462
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ ++PL +AA G L A+ ++E TP+ AA GH ++ LL +
Sbjct: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
Query: 187 FKASIFERTKD-GSTLMHIASLNGHADCAMMLFKKGVYLHM 226
A+I +T++ T + +A G + A L K G + +
Sbjct: 523 -GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL 562
Score = 59.3 bits (137), Expect = 1e-07
Identities = 44/162 (27%), Positives = 75/162 (46%), Gaps = 3/162 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL+LA AG+ +V E+L A+ + DT L LA ++ +L+
Sbjct: 1114 KKGFTPLILAATAGHVGVV-EILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLAR 1172
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPMHLAAENGHAA 178
GA + N + TPL +AA+ G ++K G N+ +P+ LAA NGH A
Sbjct: 1173 GANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTA 1232
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
++LL D + + +T + +A G + +L +
Sbjct: 1233 AVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDR 1274
Score = 58.4 bits (135), Expect = 3e-07
Identities = 49/161 (30%), Positives = 76/161 (47%), Gaps = 4/161 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL+LA G+ + V+ LL + + T +TAL LA + ++ +L+D A
Sbjct: 1218 GISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNR-NTALTLACFQGRTEVVSLLLDRKA 1276
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPMHLAAENGHAAII 180
V+ G TPL AA+ G + + G NA + T + +AA+ GH
Sbjct: 1277 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1336
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
ELL + A I R K G+T + +A+ GH D +L + G
Sbjct: 1337 ELLIGR-GAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1376
Score = 52.8 bits (121), Expect = 1e-05
Identities = 44/168 (26%), Positives = 76/168 (45%), Gaps = 6/168 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G ++++ LL+A + + G + L LAA ++L+D G+ ++
Sbjct: 1186 PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDIN 1245
Query: 126 ATNGAGQ-TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A + T L +A +G +V +AN TP+ AA G+A + +L
Sbjct: 1246 AQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1305
Query: 185 DK---FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
DK A ++D T + IA+ GH +L +G ++ + NK
Sbjct: 1306 DKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIGRGAHIDVRNK 1351
Score = 51.6 bits (118), Expect = 3e-05
Identities = 46/160 (28%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G+ + L+ + L+ G T L AAR +M +L+ GA ++
Sbjct: 470 PLTLAACGGHVELAALLI--ERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527
Query: 126 A-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A T +T L +A G + + ++A A I + TP+ AA+ GH +++ L
Sbjct: 528 AQTEETQETALTLACCGGFLEVADFL--IKAGADI-ELGCSTPLMEAAQEGHLELVKYLL 584
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
A++ T G T + A NGH D A +L + G L
Sbjct: 585 AA-GANVHATTATGDTALTYACENGHTDVADVLLQAGADL 623
Score = 51.2 bits (117), Expect = 4e-05
Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 2/165 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL+ A AG+ + R LL + ++AL LA + ++M R L++
Sbjct: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNE-FKESALTLACYKGHLEMVRFLLEA 423
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA + T L A +G + + A + + +P+ LAA GH +
Sbjct: 424 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 483
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
LL ++ AS+ E +G T + A+ GH + +L +G ++
Sbjct: 484 ALLIER-GASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527
Score = 50.8 bits (116), Expect = 5e-05
Identities = 41/165 (24%), Positives = 76/165 (46%), Gaps = 4/165 (2%)
Query: 70 AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNG 129
A G+ + VR+LL + T G++ L LA ++A++L+ A V+
Sbjct: 241 ACSEGDVNAVRKLLIE--GRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGI 298
Query: 130 AGQ-TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFK 188
G TPL AA G +VK +A+ + T + A G+ ++++L +
Sbjct: 299 KGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES-G 357
Query: 189 ASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEK 233
ASI + ++G T + A GH + A +L + G ++ + F++
Sbjct: 358 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKE 402
Score = 47.2 bits (107), Expect = 6e-04
Identities = 53/201 (26%), Positives = 83/201 (41%), Gaps = 13/201 (6%)
Query: 674 GHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG-GKQRET 732
G +++ LL + +V+ T L A V LL GADV+ R+T
Sbjct: 1263 GRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 1322
Query: 733 PLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLR 792
L IAA C L L+ GA + + G TP+ +AA G+L + LL++ G D
Sbjct: 1323 ALTIAADKGHYKFCEL-LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA 1381
Query: 793 KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALH 852
I TPL A R +VR+L++ V +S +I + + +
Sbjct: 1382 ADNRKI-------TPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITD---KEML 1431
Query: 853 YACKVTKEEVKIPTADRQVVK 873
C + E + + DRQ +
Sbjct: 1432 KKCHLCMESI-VQAKDRQAAE 1451
Score = 46.8 bits (106), Expect = 8e-04
Identities = 42/164 (25%), Positives = 71/164 (43%), Gaps = 7/164 (4%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGD-TALHLAARRRDVDMARILVD 119
+ G+ L LA AG + + LL+ + + GD T L AA V + ++L+
Sbjct: 265 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGIK--GDITPLMAAANGGHVKIVKLLLA 322
Query: 120 YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR--TPMHLAAENGHA 177
+ A V+A + G T L A A G +VK + + A+I D+ + TP+ A GH
Sbjct: 323 HKADVNAQSSTGNTALTYACAGGYVDVVKVL--LESGASIEDHNENGHTPLMEAGSAGHV 380
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ LL + + + + +A GH + L + G
Sbjct: 381 EVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424
Score = 46.8 bits (106), Expect = 8e-04
Identities = 38/146 (26%), Positives = 68/146 (46%), Gaps = 3/146 (2%)
Query: 82 LLSAQTAEQLKATTPAG-DTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAA 140
+L A + A T + DTAL LA ++ + L++ GA ++ + G TPL +AA
Sbjct: 1066 MLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAAT 1125
Query: 141 EGDEPLVKYFYGVRAN-AAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGS 199
G +V+ A+ A ++ TP+ LA G ++ELL + A+ R
Sbjct: 1126 AGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLAR-GANKEHRNVSDY 1184
Query: 200 TLMHIASLNGHADCAMMLFKKGVYLH 225
T + +A+ G+ + +L G ++
Sbjct: 1185 TPLSLAASGGYVNIIKILLNAGAEIN 1210
Score = 45.6 bits (103), Expect = 0.002
Identities = 33/123 (26%), Positives = 51/123 (41%), Gaps = 2/123 (1%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T L AA+ +++ + L+ GA V AT G T L A G + A+
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 160 ADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGS-TLMHIASLNGHADCAMMLF 218
RTP+ AA GH ++ L K A++ T + T++ +A GH +L
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISK-GANVNRTTANNDHTVLSLACAGGHLAVVELLL 684
Query: 219 KKG 221
G
Sbjct: 685 AHG 687
Score = 44.0 bits (99), Expect = 0.006
Identities = 36/115 (31%), Positives = 55/115 (47%), Gaps = 6/115 (5%)
Query: 111 VDMARILVDYGAV-VDA-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPM 168
+ + +L Y A+ +DA T T L +A A G E LV+ A+ D + TP+
Sbjct: 1061 ISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPL 1120
Query: 169 HLAAENGHAAIIELLADKFK--ASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LAA GH ++E+L D + ERTKD T + +A G + +L +G
Sbjct: 1121 ILAATAGHVGVVEILLDNGADIEAQSERTKD--TPLSLACSGGRQEVVELLLARG 1173
Score = 41.9 bits (94), Expect = 0.024
Identities = 47/165 (28%), Positives = 76/165 (46%), Gaps = 15/165 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY-TALHIAVESCKPAVVETLLGYGA 720
+G + AAR GH ++ LL +G +++ T + TAL +A V + L+ GA
Sbjct: 499 EGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA 558
Query: 721 DVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
D+ + TPL AA+ +G + LL +GA + T G T + A + G+
Sbjct: 559 DIEL----GCSTPLMEAAQ--EGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDV 612
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLI 824
+LL+ G D +++ G TPL A R+ V+ LI
Sbjct: 613 ADVLLQAGADLEHESE-------GGRTPLMKAARAGHVCTVQFLI 650
>BC043394-1|AAH43394.1| 751|Homo sapiens ANKRD17 protein protein.
Length = 751
Score = 161 bits (392), Expect = 2e-38
Identities = 143/469 (30%), Positives = 227/469 (48%), Gaps = 29/469 (6%)
Query: 920 RALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGR-SALHLAAEHGYLQVC 978
R++N G + L +AC G+ +L LL HA V+ ++G + L AA G++++
Sbjct: 258 RSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIV 317
Query: 979 DALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
LL +KA +N+++ G TAL A GY +VK L+ + A I+ TPL A +
Sbjct: 318 KLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLL-ESGASIEDHNENGHTPLMEAGS 376
Query: 1039 SGQIEVCKLLLELGANIDA-TDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGN 1097
+G +EV +LLLE GA I+ ++E + + A + E+V+ L+ + T + +
Sbjct: 377 AGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTD-EMH 435
Query: 1098 TCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGAS 1157
T A + G V+V L+ D ++ +S PL LAA GGH ++ +L+ GAS
Sbjct: 436 TALMEACMDGHVEVARLLL--DSGAQVNMPADSFES-PLTLAACGGHVELAALLIERGAS 492
Query: 1158 CTDENRAGLTAVHLAAEHGHTNVLDVM----RSTNTLRISSKKLGLTP------LHIAAY 1207
+ N G T + AA GH ++ ++ + N +++ LT L +A +
Sbjct: 493 LEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADF 552
Query: 1208 YGQAETVRELLSHVPGTVKSEAPTGVSLVPVL---GAE------SGLTPLHLAAYNGNEN 1258
+A EL P +++ + LV L GA +G T L A NG+ +
Sbjct: 553 LIKAGADIELGCSTP-LMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTD 611
Query: 1259 VVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH 1318
V +LL AG + S E G PL A GH+ V L+S+ A + +T + T L
Sbjct: 612 VADVLLQ-AGADLEHES-EGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLS 669
Query: 1319 IASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
+A GH +VE+LL GA+ K+G T L AAK GH +VV L +
Sbjct: 670 LACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
Score = 160 bits (389), Expect = 4e-38
Identities = 152/523 (29%), Positives = 228/523 (43%), Gaps = 35/523 (6%)
Query: 897 CAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVD 956
CA+ +T M A STA+ ++ NR L AC G + V LL V+
Sbjct: 210 CALDEAAAALTRMRAE-STANAGQSDNRS-------LAEACSEGDVNAVRKLLIEGRSVN 261
Query: 957 VFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGR-TALHLAAMNGYAHLVKFLI 1015
EG S L LA GY ++ LL A + + G T L AA G+ +VK L+
Sbjct: 262 EHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLL 321
Query: 1016 RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYS 1075
H A ++ + T L A A G ++V K+LLE GA+I+ +E G P+ A +
Sbjct: 322 A-HKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHV 380
Query: 1076 EVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTP 1135
EV +L L+ + + + + +A +G ++++ L++ G T
Sbjct: 381 EVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE---AGADQEHKTDEMHTA 437
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK 1195
L A GH +V R+L+ +GA + + + LAA GH + ++
Sbjct: 438 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVN 497
Query: 1196 KLGLTPLHIAAYYGQAETVRELL---SHVPGTVKSEAPTGVSL------------VPVLG 1240
G TPL AA G E V LL +++ + T ++L + G
Sbjct: 498 DEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAG 557
Query: 1241 AESGL---TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGL 1297
A+ L TPL AA G+ +V+ LL +AG A+ G L AC GH + +
Sbjct: 558 ADIELGCSTPLMEAAQEGHLELVKYLL-AAGANVH-ATTATGDTALTYACENGHTDVADV 615
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN-ATDKNGWTPLHCAAKA 1356
LL A+L H ++ G+T L A+ GH V+ L+ +GA +N T N T L A
Sbjct: 616 LLQAGADLEHESE-GGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAG 674
Query: 1357 GHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
GHL VV+LL GA P + AA H V+ YLL
Sbjct: 675 GHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
Score = 159 bits (385), Expect = 1e-37
Identities = 137/439 (31%), Positives = 210/439 (47%), Gaps = 31/439 (7%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
++VK L+ + ADV+ Q+ + TA Y G DV+ ++ + ++ N G
Sbjct: 315 KIVKLLLAHKADVNAQSSTGN-TALTYACAGGYVDVVKVLL------ESGASIEDHNENG 367
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGR-SALHLAAEHGYLQVCDALLTNKAFI 988
TPL+ A GH+++ LL N A ++ E + SAL LA G+L++ LL A
Sbjct: 368 HTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQ 427
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
K TAL A M+G+ + + L+ D A +++ ++PL LAA G +E+ LL
Sbjct: 428 EHKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVELAALL 486
Query: 1049 LELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGS 1108
+E GA+++ ++ G P+ AA+ + E+V L L Q N+ T + T +A G
Sbjct: 487 IERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGF 546
Query: 1109 VKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTA 1168
++V + L+K A +L STPL AA+ GH ++V+ L+ AGA+ G TA
Sbjct: 547 LEVADFLIK------AGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600
Query: 1169 VHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSE 1228
+ A E+GHT+V DV+ + G TPL AA G TV+ L+S ++
Sbjct: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660
Query: 1229 APTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASN-ENGYNPLHLAC 1287
A + T L LA G+ VV LLL AD ++G L A
Sbjct: 661 ------------ANNDHTVLSLACAGGHLAVVELLLAHG---ADPTHRLKDGSTMLIEAA 705
Query: 1288 FGGHMSIVGLLLSRSAELL 1306
GGH S+V LL LL
Sbjct: 706 KGGHTSVVCYLLDYPNNLL 724
Score = 146 bits (354), Expect = 7e-34
Identities = 135/516 (26%), Positives = 219/516 (42%), Gaps = 23/516 (4%)
Query: 910 IAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
I +STAD +A + ++C T + + + + RS
Sbjct: 184 IGKLSTAD-GKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 242
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKK 1029
+E G + LL +N G + L LA GY L + L+ H + D
Sbjct: 243 SE-GDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGD 301
Query: 1030 QTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
TPL AA G +++ KLLL A+++A G + A Y +VV++ L+ + +
Sbjct: 302 ITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGAS-I 360
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVR 1149
++G+T A G V+V L++ + G+ + N+ +S L LA GH ++VR
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLE-NGAGINTHSNEFKESA-LTLACYKGHLEMVR 418
Query: 1150 VLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYG 1209
L+ AGA + TA+ A GH V ++ + +PL +AA G
Sbjct: 419 FLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG 478
Query: 1210 QAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGV 1269
E L+ G SL V + G TPL AA G+E +V LLL G
Sbjct: 479 HVELAALLIER-----------GASLEEV--NDEGYTPLMEAAREGHEEMVALLLGQ-GA 524
Query: 1270 QADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMV 1329
+A + E L LAC GG + + L+ A++ + T L A+ GH ++V
Sbjct: 525 NINAQTEETQETALTLACCGGFLEVADFLIKAGADI----ELGCSTPLMEAAQEGHLELV 580
Query: 1330 EVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASE 1389
+ LL GA ++AT G T L A + GH +V +L ++GA + E+ P+ AA
Sbjct: 581 KYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARA 640
Query: 1390 NHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNH 1425
H +++L+ K + + + C+ H
Sbjct: 641 GHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGH 676
Score = 111 bits (266), Expect = 3e-23
Identities = 116/433 (26%), Positives = 186/433 (42%), Gaps = 36/433 (8%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A G+V ++ LL+ G S++ + +T L A + V LL GA +
Sbjct: 334 GNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGI 393
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + +E+ L +A + LL++GA T++ T + A G++ L
Sbjct: 394 NTHSNEFKESALTLAC-YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 452
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL+ G + E+PL +A ++ LIE +G S ++
Sbjct: 453 LLDSGAQVNMPAD-------SFESPLTLAACGGHVELAALLIE-----RGAS-----LEE 495
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
V+++G + L A + EE+ V L+ GA+++ QT ETA G
Sbjct: 496 VNDEGYTPLMEAAREGHEEM---------VALLLGQGANINAQTEETQETALTLACCGGF 546
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
+V +I + AD+ + TPL+ A GH++LV LL A V G
Sbjct: 547 LEVADFLIK--AGADIELGCS-------TPLMEAAQEGHLELVKYLLAAGANVHATTATG 597
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+AL A E+G+ V D LL A + ++ GRT L AA G+ V+FLI +
Sbjct: 598 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVN 657
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
T L LA A G + V +LLL GA+ + G + AA+ ++ VV L
Sbjct: 658 RTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
Query: 1083 QQHPNLVMATTKD 1095
NL+ A D
Sbjct: 718 DYPNNLLSAPPPD 730
Score = 81.0 bits (191), Expect = 4e-14
Identities = 54/153 (35%), Positives = 76/153 (49%), Gaps = 4/153 (2%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL+ A + G+ +V+ LL+A + ATT GDTAL A D+A +L+ GA ++
Sbjct: 567 PLMEAAQEGHLELVKYLLAA--GANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA-AIADNEDRTPMHLAAENGHAAIIELLA 184
+ G+TPL AA G V++ AN N D T + LA GH A++ELL
Sbjct: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLL 684
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
A R KDGST++ A+ GH L
Sbjct: 685 -AHGADPTHRLKDGSTMLIEAAKGGHTSVVCYL 716
Score = 66.1 bits (154), Expect = 1e-09
Identities = 48/168 (28%), Positives = 81/168 (48%), Gaps = 4/168 (2%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL+ A G+ +V+ LL A A+ + A + G+TAL A VD+ ++L++ GA ++
Sbjct: 304 PLMAAANGGHVKIVK-LLLAHKAD-VNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE 361
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAAENGHAAIIELLA 184
N G TPL A + G + + A NE + + + LA GH ++ L
Sbjct: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 421
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFE 232
+ A +T + T + A ++GH + A +L G ++MP FE
Sbjct: 422 EA-GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 468
Score = 59.7 bits (138), Expect = 1e-07
Identities = 50/161 (31%), Positives = 78/161 (48%), Gaps = 4/161 (2%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G+ MVR LL A ++ K T TAL A V++AR+L+D GA V+
Sbjct: 405 LTLACYKGHLEMVRFLLEAGADQEHK--TDEMHTALMEACMDGHVEVARLLLDSGAQVNM 462
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ ++PL +AA G L A+ ++E TP+ AA GH ++ LL +
Sbjct: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
Query: 187 FKASIFERTKD-GSTLMHIASLNGHADCAMMLFKKGVYLHM 226
A+I +T++ T + +A G + A L K G + +
Sbjct: 523 -GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL 562
Score = 51.6 bits (118), Expect = 3e-05
Identities = 46/160 (28%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G+ + L+ + L+ G T L AAR +M +L+ GA ++
Sbjct: 470 PLTLAACGGHVELAALLI--ERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527
Query: 126 A-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A T +T L +A G + + ++A A I + TP+ AA+ GH +++ L
Sbjct: 528 AQTEETQETALTLACCGGFLEVADFL--IKAGADI-ELGCSTPLMEAAQEGHLELVKYLL 584
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
A++ T G T + A NGH D A +L + G L
Sbjct: 585 AA-GANVHATTATGDTALTYACENGHTDVADVLLQAGADL 623
Score = 51.2 bits (117), Expect = 4e-05
Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 2/165 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL+ A AG+ + R LL + ++AL LA + ++M R L++
Sbjct: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNE-FKESALTLACYKGHLEMVRFLLEA 423
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA + T L A +G + + A + + +P+ LAA GH +
Sbjct: 424 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 483
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
LL ++ AS+ E +G T + A+ GH + +L +G ++
Sbjct: 484 ALLIER-GASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527
Score = 50.8 bits (116), Expect = 5e-05
Identities = 41/165 (24%), Positives = 76/165 (46%), Gaps = 4/165 (2%)
Query: 70 AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNG 129
A G+ + VR+LL + T G++ L LA ++A++L+ A V+
Sbjct: 241 ACSEGDVNAVRKLLIE--GRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGI 298
Query: 130 AGQ-TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFK 188
G TPL AA G +VK +A+ + T + A G+ ++++L +
Sbjct: 299 KGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES-G 357
Query: 189 ASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEK 233
ASI + ++G T + A GH + A +L + G ++ + F++
Sbjct: 358 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKE 402
Score = 46.8 bits (106), Expect = 8e-04
Identities = 42/164 (25%), Positives = 71/164 (43%), Gaps = 7/164 (4%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGD-TALHLAARRRDVDMARILVD 119
+ G+ L LA AG + + LL+ + + GD T L AA V + ++L+
Sbjct: 265 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGIK--GDITPLMAAANGGHVKIVKLLLA 322
Query: 120 YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR--TPMHLAAENGHA 177
+ A V+A + G T L A A G +VK + + A+I D+ + TP+ A GH
Sbjct: 323 HKADVNAQSSTGNTALTYACAGGYVDVVKVL--LESGASIEDHNENGHTPLMEAGSAGHV 380
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ LL + + + + +A GH + L + G
Sbjct: 381 EVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424
Score = 45.6 bits (103), Expect = 0.002
Identities = 33/123 (26%), Positives = 51/123 (41%), Gaps = 2/123 (1%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T L AA+ +++ + L+ GA V AT G T L A G + A+
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 160 ADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGS-TLMHIASLNGHADCAMMLF 218
RTP+ AA GH ++ L K A++ T + T++ +A GH +L
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISK-GANVNRTTANNDHTVLSLACAGGHLAVVELLL 684
Query: 219 KKG 221
G
Sbjct: 685 AHG 687
Score = 41.9 bits (94), Expect = 0.024
Identities = 47/165 (28%), Positives = 76/165 (46%), Gaps = 15/165 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY-TALHIAVESCKPAVVETLLGYGA 720
+G + AAR GH ++ LL +G +++ T + TAL +A V + L+ GA
Sbjct: 499 EGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA 558
Query: 721 DVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
D+ + TPL AA+ +G + LL +GA + T G T + A + G+
Sbjct: 559 DIEL----GCSTPLMEAAQ--EGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDV 612
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLI 824
+LL+ G D +++ G TPL A R+ V+ LI
Sbjct: 613 ADVLLQAGADLEHESE-------GGRTPLMKAARAGHVCTVQFLI 650
>BC098394-1|AAH98394.1| 1327|Homo sapiens tankyrase, TRF1-interacting
ankyrin-related ADP-ribose polymerase protein.
Length = 1327
Score = 161 bits (391), Expect = 2e-38
Identities = 168/613 (27%), Positives = 267/613 (43%), Gaps = 79/613 (12%)
Query: 806 TPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIP 865
+PL A D+V HL++ A + A D+ G LH AC EV
Sbjct: 218 SPLHFAAGFGRKDVVEHLLQM----------GANVHARDDGGLIPLHNACSFGHAEV--- 264
Query: 866 TADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAH------------- 912
V L+ GAD + + N+ T H AI G DV ++ H
Sbjct: 265 ------VSLLLCQGADPNARDNWNY-TPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKS 317
Query: 913 -ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSA--LHLA 969
+ AD S LL A G+ + + LLT V+ +GR + LHLA
Sbjct: 318 ALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTP-LNVNCHASDGRKSTPLHLA 376
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKK 1029
A + +++ LL + A +++K + G LH A G+ + + L++ H A ++ + L +
Sbjct: 377 AGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLK-HGACVNAMDLWQ 435
Query: 1030 QTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
TPLH AA+ ++EVC LLL GA+ + G+ + A E + + H L
Sbjct: 436 FTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQ 495
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA---D 1146
A D +A ++ ++ + E++ F + + T L A H
Sbjct: 496 AAREAD------LAKVKKTLAL--EIINF--------KQPQSHETALHCAVASLHPKRKQ 539
Query: 1147 VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
V +L+R GA+ ++N+ +T +H+AAE H +V++V+ + LG T LH AA
Sbjct: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAA 599
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS 1266
G +T R LLS+ P+ +SL G T AA GNE V ++L S
Sbjct: 600 LAGHLQTCRLLLSY------GSDPSIISL-------QGFT----AAQMGNEAVQQILSES 642
Query: 1267 AGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHY 1326
++ +++ Y L + G ++ L S++ RH T LH A+ +
Sbjct: 643 TPIR----TSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHS-TPLHFAAGYNRV 697
Query: 1327 QMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFA 1386
+VE LL GA+++A DK G PLH A GH V +LL GAS P+ A
Sbjct: 698 SVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEA 757
Query: 1387 ASENHNDVLEYLL 1399
A++ ++ + LL
Sbjct: 758 AAKGKYEICKLLL 770
Score = 152 bits (369), Expect = 1e-35
Identities = 195/754 (25%), Positives = 307/754 (40%), Gaps = 81/754 (10%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H A +GH +++ LL +G + N NYT LH A K V LL +GAD
Sbjct: 249 GLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADP 308
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+IR DG K AL L A E + AA+ GN L+
Sbjct: 309 NIRN--------------TDG-KSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMA 353
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL PL C TPL +A IV+ L++ D + A
Sbjct: 354 LLT----PLNVN--CHASDGRKSTPLHLAAGYNRVRIVQLLLQHGAD----------VHA 397
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
D+ G LH AC EV + L+++GA V+ T H A
Sbjct: 398 KDKGGLVPLHNACSYGHYEV---------TELLLKHGACVNAMDLWQF-TPLHEAASKNR 447
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPL------LIACHRGHMQLVNTLLTNHARV- 955
+V + +++H + + + ++++ P L +GH L + A+V
Sbjct: 448 VEVCSLLLSHGADPTLVNC-HGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVK 506
Query: 956 -----DVFDVEG----RSALHLAAEHGY---LQVCDALLTNKAFINSKARNGRTALHLAA 1003
++ + + +ALH A + QV + LL A +N K ++ T LH+AA
Sbjct: 507 KTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAA 566
Query: 1004 MNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQ 1063
+ +++ L + H A ++ L QT LH AA +G ++ C+LLL G++ G
Sbjct: 567 ERAHNDVMEVLHK-HGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQG- 624
Query: 1064 KPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGV 1123
AAQ V Q+ + P T D + A+ G ++ +++L
Sbjct: 625 ---FTAAQMGNEAVQQILSESTP----IRTSDVDYRLLEASKAGDLETVKQLCSSQNVNC 677
Query: 1124 ISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDV 1183
+ STPL AA VV L+ GA +++ GL +H A +GH V ++
Sbjct: 678 RDLEGR--HSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAEL 735
Query: 1184 MRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKS--EAPTGVSLVP---- 1237
+ + TPLH AA G+ E + LL H K + T + LV
Sbjct: 736 LVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDT 795
Query: 1238 -VLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVG 1296
+ G L AA G V+ L + N PLHLA ++ +
Sbjct: 796 DIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNS-TPLHLAAGYNNLEVAE 854
Query: 1297 LLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKA 1356
LL A++ ++ D+ G LH A+++GH + +L+ +NATDK +TPLH AA+
Sbjct: 855 YLLEHGADV-NAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQK 913
Query: 1357 GHLNVVKLLCESGASPKSETNLNCAPIWFAASEN 1390
G + LL GA P + P+ A +++
Sbjct: 914 GRTQLCALLLAHGADPTMKNQEGQTPLDLATADD 947
Score = 119 bits (287), Expect = 1e-25
Identities = 87/255 (34%), Positives = 120/255 (47%), Gaps = 12/255 (4%)
Query: 1133 STPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
S+PL AA G DVV L++ GA+ + GL +H A GH V+ ++
Sbjct: 217 SSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPN 276
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHV--PGTVKSEAPTGVSLVP-----VLGAESGL 1245
+ TPLH AA G+ + LL H P ++ + + L VL E
Sbjct: 277 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKK 336
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
L AA +GNE + LL V A+ PLHLA + IV LLL A++
Sbjct: 337 DELLEAARSGNEEKLMALLTPLNVNCHASDGRKS-TPLHLAAGYNRVRIVQLLLQHGADV 395
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
H+ D+ G LH A ++GHY++ E+LL GA +NA D +TPLH AA + V LL
Sbjct: 396 -HAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLL 454
Query: 1366 CESGASPKSETNLNC 1380
GA P T +NC
Sbjct: 455 LSHGADP---TLVNC 466
Score = 118 bits (285), Expect = 2e-25
Identities = 162/596 (27%), Positives = 251/596 (42%), Gaps = 73/596 (12%)
Query: 662 DGARS--IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYG 719
DG +S +H AA Y V I+ LLQ G V LH A V E LL +G
Sbjct: 366 DGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHG 425
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAA------- 772
A V+ Q TPLH AA + C+L LL GA P G + V +A
Sbjct: 426 ACVNAMDLWQ-FTPLHEAASKNRVEVCSL-LLSHGADPTLVNCHGKSAVDMAPTPELRER 483
Query: 773 ---KFGNLATLVLLLEDGGDPLRKTK----VCIYDVVTGETPLQMACRSCMPDIVRHLIE 825
+F + L E ++KT + + ET L A S P R +
Sbjct: 484 LTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPK--RKQVT 541
Query: 826 FVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV-SL 884
+ KG +V+ ++D + LH A + A V++ L ++GA + +L
Sbjct: 542 ELLLRKGANVNEK-----NKDFMTPLHVAAE---------RAHNDVMEVLHKHGAKMNAL 587
Query: 885 QTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQL 944
T +TA H A+AG H+ T + + SI A G+ +
Sbjct: 588 DTL--GQTALHRAALAG----------HLQTCRLLLSYGSDPSIISLQGFTAAQMGN-EA 634
Query: 945 VNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGR--TALHLA 1002
V +L+ + DV+ R L A++ G L+ L +++ +N + GR T LH A
Sbjct: 635 VQQILSESTPIRTSDVDYR--LLEASKAGDLETVKQLCSSQN-VNCRDLEGRHSTPLHFA 691
Query: 1003 AMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELG 1062
A +V++L+ H A + PLH A + G EV +LL+ GA+++ D
Sbjct: 692 AGYNRVSVVEYLLH-HGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750
Query: 1063 QKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA-----IQGSVKVIEELMK 1117
P+H AA E+ +L L +H +DGNT + IQ ++ L+
Sbjct: 751 FTPLHEAAAKGKYEICKLLL-KHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLD 809
Query: 1118 FDRTGVISARNKL-------------NDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
+ G ++ KL +STPL LAA + +V L+ GA +++
Sbjct: 810 AAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKG 869
Query: 1165 GLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSH 1220
GL +H AA +GH ++ ++ NT ++ K TPLH AA G+ + LL+H
Sbjct: 870 GLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAH 925
Score = 116 bits (280), Expect = 7e-25
Identities = 155/576 (26%), Positives = 243/576 (42%), Gaps = 60/576 (10%)
Query: 872 VKCLIENGADVSLQTRHNHETA-FHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGW 930
VK L++ A+V+ + +++ H+ A G DV+ ++ + ++ ++ G
Sbjct: 198 VKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLL------QMGANVHARDDGGL 250
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
PL AC GH ++V+ LL A + D + LH AA G + VC LL + A N
Sbjct: 251 IPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNI 310
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
+ +G++AL LA + A L KK L A + + ++ LL
Sbjct: 311 RNTDGKSALDLADPSAKAVLTG-------------EYKKDELLEAARSGNEEKLMALLTP 357
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
L N A+D P+H AA N +VQL LQ H V A K G H A G +
Sbjct: 358 LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQ-HGADVHAKDKGGLVPLHNACSYGHYE 416
Query: 1111 VIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVH 1170
V E L+K ++A + L TPL AA +V +L+ GA T N G +AV
Sbjct: 417 VTELLLKHG--ACVNAMD-LWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVD 473
Query: 1171 LAAE-----------HGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
+A GH+ +L R + ++ K L L ++ + Q ++ L
Sbjct: 474 MAPTPELRERLTYEFKGHS-LLQAAREADLAKVK-KTLALEIIN----FKQPQSHETALH 527
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESG------LTPLHLAAYNGNENVVRLLLNSAGVQADA 1273
++ + L+ GA +TPLH+AA + +V+ +L + G + +A
Sbjct: 528 CAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVL-HKHGAKMNA 586
Query: 1274 ASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLL 1333
G LH A GH+ LLLS ++ G T + + + V+ +L
Sbjct: 587 LDTL-GQTALHRAALAGHLQTCRLLLSYGSDP-SIISLQGFTAAQMGN-----EAVQQIL 639
Query: 1334 GQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCES-GASPKSETNLNCAPIWFAASENHN 1392
+ I +D + L A+KAG L VK LC S + + + P+ FAA N
Sbjct: 640 SESTPIRTSDVD--YRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRV 697
Query: 1393 DVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNI 1428
V+EYLLH D + D V CS H +
Sbjct: 698 SVVEYLLHHGADVHA-KDKGGLVPLHNACSYGHYEV 732
Score = 98.7 bits (235), Expect = 2e-19
Identities = 120/441 (27%), Positives = 184/441 (41%), Gaps = 61/441 (13%)
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A NG VK L+ N + +K +PLH AA G+ +V + LL++GAN+ A D+
Sbjct: 189 ACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDG 248
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQ--HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFD 1119
G P+H A ++EVV L L Q PN A T H AAI+G + V L++
Sbjct: 249 GLIPLHNACSFGHAEVVSLLLCQGADPN---ARDNWNYTPLHEAAIKGKIDVCIVLLQHG 305
Query: 1120 RTGVI---SARNKLNDSTP---------------LQLAAEGGHADVVRVLVRAGASCTDE 1161
I ++ L+ + P L+ A G ++ +L +C
Sbjct: 306 ADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHAS 365
Query: 1162 NRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
+ T +HLAA + ++ ++ + K GL PLH A YG E LL H
Sbjct: 366 DGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKH- 424
Query: 1222 PGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYN 1281
+ L TPLH AA V LLL S G N +G +
Sbjct: 425 -----GACVNAMDLWQ-------FTPLHEAASKNRVEVCSLLL-SHGADPTLV-NCHGKS 470
Query: 1282 PLHLAC-----------FGGH--------MSIVGLLLSRSAELLH-STDRHGKTGLH--I 1319
+ +A F GH + + + + E+++ + +T LH +
Sbjct: 471 AVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAV 530
Query: 1320 ASTH-GHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNL 1378
AS H Q+ E+LL +GA +N +K+ TPLH AA+ H +V+++L + GA + L
Sbjct: 531 ASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTL 590
Query: 1379 NCAPIWFAASENHNDVLEYLL 1399
+ AA H LL
Sbjct: 591 GQTALHRAALAGHLQTCRLLL 611
Score = 65.3 bits (152), Expect = 2e-09
Identities = 45/121 (37%), Positives = 58/121 (47%), Gaps = 4/121 (3%)
Query: 1286 ACFGGHMSIVGLLLSRSAELLHSTDRHGKTG--LHIASTHGHYQMVEVLLGQGAEINATD 1343
AC G +S V L+ A +++ D G+ LH A+ G +VE LL GA ++A D
Sbjct: 189 ACRNGDVSRVKRLVD--AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARD 246
Query: 1344 KNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEH 1403
G PLH A GH VV LL GA P + N N P+ AA + DV LL
Sbjct: 247 DGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGA 306
Query: 1404 D 1404
D
Sbjct: 307 D 307
Score = 59.3 bits (137), Expect = 1e-07
Identities = 46/158 (29%), Positives = 75/158 (47%), Gaps = 4/158 (2%)
Query: 49 KEWKKLIRDLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARR 108
KE I+DL+ RG LL A + G + V++L + + + T T LHLAA
Sbjct: 791 KEGDTDIQDLL--RGDAALLDAAKKGCLARVQKLCTPENIN-CRDTQGRNSTPLHLAAGY 847
Query: 109 RDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPM 168
++++A L+++GA V+A + G PLH AA+ G + D TP+
Sbjct: 848 NNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 907
Query: 169 HLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIAS 206
H AA+ G + LL A + ++G T + +A+
Sbjct: 908 HEAAQKGRTQLCALLL-AHGADPTMKNQEGQTPLDLAT 944
Score = 58.4 bits (135), Expect = 3e-07
Identities = 46/151 (30%), Positives = 70/151 (46%), Gaps = 3/151 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
LL A +AG+ V++L S+Q + T LH AA V + L+ +GA V A
Sbjct: 654 LLEASKAGDLETVKQLCSSQNVN-CRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA 712
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G PLH A + G + + A+ +AD TP+H AA G I +LL K
Sbjct: 713 KDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLL-K 771
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMML 217
A ++ +DG+T + + G D +L
Sbjct: 772 HGADPTKKNRDGNTPLDLVK-EGDTDIQDLL 801
Score = 54.4 bits (125), Expect = 4e-06
Identities = 39/119 (32%), Positives = 60/119 (50%), Gaps = 4/119 (3%)
Query: 105 AARRRDVDMARILVDYGAVVDATNGAGQ--TPLHIAAAEGDEPLVKYFYGVRANAAIADN 162
A R DV + LVD A V+A + AG+ +PLH AA G + +V++ + AN D+
Sbjct: 189 ACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDD 247
Query: 163 EDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
P+H A GHA ++ LL + A R T +H A++ G D ++L + G
Sbjct: 248 GGLIPLHNACSFGHAEVVSLLLCQ-GADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG 305
Score = 54.0 bits (124), Expect = 5e-06
Identities = 40/133 (30%), Positives = 62/133 (46%), Gaps = 3/133 (2%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL LA N + LL + + A G LH AA VD+A +L+ Y
Sbjct: 836 RNSTPLHLAAGYNNLEVAEYLL--EHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYN 893
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLA-AENGHAAII 180
V+AT+ TPLH AA +G L A+ + + E +TP+ LA A++ A +I
Sbjct: 894 TCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLI 953
Query: 181 ELLADKFKASIFE 193
+ + + + F+
Sbjct: 954 DAMPPEALPTCFK 966
Score = 47.2 bits (107), Expect = 6e-04
Identities = 44/146 (30%), Positives = 62/146 (42%), Gaps = 4/146 (2%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
LL A G+ S V+ L+ A K + LH AA D+ L+ GA V A
Sbjct: 186 LLEACRNGDVSRVKRLVDAANVNA-KDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHA 244
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI-IELLAD 185
+ G PLH A + G +V A+ DN + TP+H AA G + I LL
Sbjct: 245 RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 304
Query: 186 KFKASIFERTKDGSTLMHIASLNGHA 211
+I R DG + + +A + A
Sbjct: 305 GADPNI--RNTDGKSALDLADPSAKA 328
Score = 40.3 bits (90), Expect = 0.072
Identities = 26/86 (30%), Positives = 45/86 (52%), Gaps = 4/86 (4%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T LH+AA R D+ +L +GA ++A + GQT LH AA G + ++ +I
Sbjct: 560 TPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619
Query: 160 ADNEDRTPMHLAAENGHAAIIELLAD 185
+ T AA+ G+ A+ ++L++
Sbjct: 620 ISLQGFT----AAQMGNEAVQQILSE 641
Score = 39.1 bits (87), Expect = 0.17
Identities = 31/90 (34%), Positives = 43/90 (47%), Gaps = 7/90 (7%)
Query: 99 DTALHLAARR---RDVDMARILVDYGAVVDATNGAGQTPLHIAA--AEGDEPLVKYFYGV 153
+TALH A + + +L+ GA V+ N TPLH+AA A D V + +G
Sbjct: 523 ETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGA 582
Query: 154 RANAAIADNEDRTPMHLAAENGHAAIIELL 183
+ NA D +T +H AA GH LL
Sbjct: 583 KMNA--LDTLGQTALHRAALAGHLQTCRLL 610
Score = 38.3 bits (85), Expect = 0.29
Identities = 30/123 (24%), Positives = 46/123 (37%), Gaps = 1/123 (0%)
Query: 99 DTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAA 158
D L A + + +L A++G TPLH+AA +V+ A+
Sbjct: 337 DELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVH 396
Query: 159 IADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF 218
D P+H A GH + ELL K A + T +H A+ + +L
Sbjct: 397 AKDKGGLVPLHNACSYGHYEVTELLL-KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 455
Query: 219 KKG 221
G
Sbjct: 456 SHG 458
Score = 38.3 bits (85), Expect = 0.29
Identities = 22/67 (32%), Positives = 33/67 (49%), Gaps = 1/67 (1%)
Query: 155 ANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCA 214
AN + + TP+H+AAE H ++E+L K A + G T +H A+L GH
Sbjct: 549 ANVNEKNKDFMTPLHVAAERAHNDVMEVL-HKHGAKMNALDTLGQTALHRAALAGHLQTC 607
Query: 215 MMLFKKG 221
+L G
Sbjct: 608 RLLLSYG 614
>AF082556-1|AAC79841.1| 1327|Homo sapiens TRF1-interacting
ankyrin-related ADP-ribose polymerase protein.
Length = 1327
Score = 161 bits (391), Expect = 2e-38
Identities = 168/613 (27%), Positives = 267/613 (43%), Gaps = 79/613 (12%)
Query: 806 TPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIP 865
+PL A D+V HL++ A + A D+ G LH AC EV
Sbjct: 218 SPLHFAAGFGRKDVVEHLLQM----------GANVHARDDGGLIPLHNACSFGHAEV--- 264
Query: 866 TADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAH------------- 912
V L+ GAD + + N+ T H AI G DV ++ H
Sbjct: 265 ------VSLLLCQGADPNARDNWNY-TPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKS 317
Query: 913 -ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSA--LHLA 969
+ AD S LL A G+ + + LLT V+ +GR + LHLA
Sbjct: 318 ALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTP-LNVNCHASDGRKSTPLHLA 376
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKK 1029
A + +++ LL + A +++K + G LH A G+ + + L++ H A ++ + L +
Sbjct: 377 AGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLK-HGACVNAMDLWQ 435
Query: 1030 QTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
TPLH AA+ ++EVC LLL GA+ + G+ + A E + + H L
Sbjct: 436 FTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQ 495
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA---D 1146
A D +A ++ ++ + E++ F + + T L A H
Sbjct: 496 AAREAD------LAKVKKTLAL--EIINF--------KQPQSHETALHCAVASLHPKRKQ 539
Query: 1147 VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
V +L+R GA+ ++N+ +T +H+AAE H +V++V+ + LG T LH AA
Sbjct: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAA 599
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS 1266
G +T R LLS+ P+ +SL G T AA GNE V ++L S
Sbjct: 600 LAGHLQTCRLLLSY------GSDPSIISL-------QGFT----AAQMGNEAVQQILSES 642
Query: 1267 AGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHY 1326
++ +++ Y L + G ++ L S++ RH T LH A+ +
Sbjct: 643 TPIR----TSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHS-TPLHFAAGYNRV 697
Query: 1327 QMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFA 1386
+VE LL GA+++A DK G PLH A GH V +LL GAS P+ A
Sbjct: 698 SVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEA 757
Query: 1387 ASENHNDVLEYLL 1399
A++ ++ + LL
Sbjct: 758 AAKGKYEICKLLL 770
Score = 153 bits (370), Expect = 9e-36
Identities = 195/754 (25%), Positives = 307/754 (40%), Gaps = 81/754 (10%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H A +GH +++ LL +G + N NYT LH A K V LL +GAD
Sbjct: 249 GLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADP 308
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+IR DG K AL L A E + AA+ GN L+
Sbjct: 309 NIRN--------------TDG-KSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMA 353
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL PL C TPL +A IV+ L++ D + A
Sbjct: 354 LLT----PLNVN--CHASDGRKSTPLHLAAGYNRVRIVQLLLQHGAD----------VHA 397
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
D+ G LH AC EV + L+++GA V+ T H A
Sbjct: 398 KDKGGLVPLHNACSYGHYEV---------TELLLKHGACVNAMDLWQF-TPLHEAASKNR 447
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPL------LIACHRGHMQLVNTLLTNHARV- 955
+V + +++H + + + ++++ P L +GH L + A+V
Sbjct: 448 VEVCSLLLSHGADPTLVNC-HGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVK 506
Query: 956 -----DVFDVEG----RSALHLAAEHGY---LQVCDALLTNKAFINSKARNGRTALHLAA 1003
++ + + +ALH A + QV + LL A +N K ++ T LH+AA
Sbjct: 507 KTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAA 566
Query: 1004 MNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQ 1063
+ +++ L + H A ++ L QT LH AA +G ++ C+LLL G++ G
Sbjct: 567 ERAHNDVMEVLHK-HGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQG- 624
Query: 1064 KPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGV 1123
AAQ V Q+ + P T D + A+ G ++ +++L
Sbjct: 625 ---FTAAQMGNEAVQQILSESTP----IRTSDVDYRLLEASKAGDLETVKQLCSSQNVNC 677
Query: 1124 ISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDV 1183
+ STPL AA VV L+ GA +++ GL +H A +GH V ++
Sbjct: 678 RDLEGR--HSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAEL 735
Query: 1184 MRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKS--EAPTGVSLVP---- 1237
+ + TPLH AA G+ E + LL H K + T + LV
Sbjct: 736 LVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDT 795
Query: 1238 -VLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVG 1296
+ G L AA G V+ L + N PLHLA ++ +
Sbjct: 796 DIQDLLKGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNS-TPLHLAAGYNNLEVAE 854
Query: 1297 LLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKA 1356
LL A++ ++ D+ G LH A+++GH + +L+ +NATDK +TPLH AA+
Sbjct: 855 YLLEHGADV-NAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQK 913
Query: 1357 GHLNVVKLLCESGASPKSETNLNCAPIWFAASEN 1390
G + LL GA P + P+ A +++
Sbjct: 914 GRTQLCALLLAHGADPTMKNQEGQTPLDLATADD 947
Score = 120 bits (288), Expect = 7e-26
Identities = 163/596 (27%), Positives = 251/596 (42%), Gaps = 73/596 (12%)
Query: 662 DGARS--IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYG 719
DG +S +H AA Y V I+ LLQ G V LH A V E LL +G
Sbjct: 366 DGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHG 425
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAA------- 772
A V+ Q TPLH AA + C+L LL GA P G + V +A
Sbjct: 426 ACVNAMDLWQ-FTPLHEAASKNRVEVCSL-LLSHGADPTLVNCHGKSAVDMAPTPELRER 483
Query: 773 ---KFGNLATLVLLLEDGGDPLRKTK----VCIYDVVTGETPLQMACRSCMPDIVRHLIE 825
+F + L E ++KT + + ET L A S P R +
Sbjct: 484 LTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPK--RKQVT 541
Query: 826 FVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV-SL 884
+ KG +V+ ++D + LH A + A V++ L ++GA + +L
Sbjct: 542 ELLLRKGANVNEK-----NKDFMTPLHVAAE---------RAHNDVMEVLHKHGAKMNAL 587
Query: 885 QTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQL 944
T +TA H A+AG H+ T + + SI A G+ +
Sbjct: 588 DTL--GQTALHRAALAG----------HLQTCRLLLSYGSDPSIISLQGFTAAQMGN-EA 634
Query: 945 VNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGR--TALHLA 1002
V +L+ + DV+ R L A++ G L+ L +++ +N + GR T LH A
Sbjct: 635 VQQILSESTPIRTSDVDYR--LLEASKAGDLETVKQLCSSQN-VNCRDLEGRHSTPLHFA 691
Query: 1003 AMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELG 1062
A +V++L+ H A + PLH A + G EV +LL+ GA+++ D
Sbjct: 692 AGYNRVSVVEYLLH-HGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750
Query: 1063 QKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA-----IQGSVKVIEELMK 1117
P+H AA E+ +L L +H +DGNT + IQ +K L+
Sbjct: 751 FTPLHEAAAKGKYEICKLLL-KHGADPTKKNRDGNTPLDLVKEGDTDIQDLLKGDAALLD 809
Query: 1118 FDRTGVISARNKL-------------NDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
+ G ++ KL +STPL LAA + +V L+ GA +++
Sbjct: 810 AAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKG 869
Query: 1165 GLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSH 1220
GL +H AA +GH ++ ++ NT ++ K TPLH AA G+ + LL+H
Sbjct: 870 GLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAH 925
Score = 119 bits (287), Expect = 1e-25
Identities = 87/255 (34%), Positives = 120/255 (47%), Gaps = 12/255 (4%)
Query: 1133 STPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
S+PL AA G DVV L++ GA+ + GL +H A GH V+ ++
Sbjct: 217 SSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPN 276
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHV--PGTVKSEAPTGVSLVP-----VLGAESGL 1245
+ TPLH AA G+ + LL H P ++ + + L VL E
Sbjct: 277 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKK 336
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
L AA +GNE + LL V A+ PLHLA + IV LLL A++
Sbjct: 337 DELLEAARSGNEEKLMALLTPLNVNCHASDGRKS-TPLHLAAGYNRVRIVQLLLQHGADV 395
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
H+ D+ G LH A ++GHY++ E+LL GA +NA D +TPLH AA + V LL
Sbjct: 396 -HAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLL 454
Query: 1366 CESGASPKSETNLNC 1380
GA P T +NC
Sbjct: 455 LSHGADP---TLVNC 466
Score = 116 bits (280), Expect = 7e-25
Identities = 155/576 (26%), Positives = 243/576 (42%), Gaps = 60/576 (10%)
Query: 872 VKCLIENGADVSLQTRHNHETA-FHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGW 930
VK L++ A+V+ + +++ H+ A G DV+ ++ + ++ ++ G
Sbjct: 198 VKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLL------QMGANVHARDDGGL 250
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
PL AC GH ++V+ LL A + D + LH AA G + VC LL + A N
Sbjct: 251 IPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNI 310
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
+ +G++AL LA + A L KK L A + + ++ LL
Sbjct: 311 RNTDGKSALDLADPSAKAVLTG-------------EYKKDELLEAARSGNEEKLMALLTP 357
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
L N A+D P+H AA N +VQL LQ H V A K G H A G +
Sbjct: 358 LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQ-HGADVHAKDKGGLVPLHNACSYGHYE 416
Query: 1111 VIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVH 1170
V E L+K ++A + L TPL AA +V +L+ GA T N G +AV
Sbjct: 417 VTELLLKHG--ACVNAMD-LWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVD 473
Query: 1171 LAAE-----------HGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
+A GH+ +L R + ++ K L L ++ + Q ++ L
Sbjct: 474 MAPTPELRERLTYEFKGHS-LLQAAREADLAKVK-KTLALEIIN----FKQPQSHETALH 527
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESG------LTPLHLAAYNGNENVVRLLLNSAGVQADA 1273
++ + L+ GA +TPLH+AA + +V+ +L + G + +A
Sbjct: 528 CAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVL-HKHGAKMNA 586
Query: 1274 ASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLL 1333
G LH A GH+ LLLS ++ G T + + + V+ +L
Sbjct: 587 LDTL-GQTALHRAALAGHLQTCRLLLSYGSDP-SIISLQGFTAAQMGN-----EAVQQIL 639
Query: 1334 GQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCES-GASPKSETNLNCAPIWFAASENHN 1392
+ I +D + L A+KAG L VK LC S + + + P+ FAA N
Sbjct: 640 SESTPIRTSDVD--YRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRV 697
Query: 1393 DVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNI 1428
V+EYLLH D + D V CS H +
Sbjct: 698 SVVEYLLHHGADVHA-KDKGGLVPLHNACSYGHYEV 732
Score = 98.7 bits (235), Expect = 2e-19
Identities = 120/441 (27%), Positives = 184/441 (41%), Gaps = 61/441 (13%)
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A NG VK L+ N + +K +PLH AA G+ +V + LL++GAN+ A D+
Sbjct: 189 ACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDG 248
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQ--HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFD 1119
G P+H A ++EVV L L Q PN A T H AAI+G + V L++
Sbjct: 249 GLIPLHNACSFGHAEVVSLLLCQGADPN---ARDNWNYTPLHEAAIKGKIDVCIVLLQHG 305
Query: 1120 RTGVI---SARNKLNDSTP---------------LQLAAEGGHADVVRVLVRAGASCTDE 1161
I ++ L+ + P L+ A G ++ +L +C
Sbjct: 306 ADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHAS 365
Query: 1162 NRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
+ T +HLAA + ++ ++ + K GL PLH A YG E LL H
Sbjct: 366 DGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKH- 424
Query: 1222 PGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYN 1281
+ L TPLH AA V LLL S G N +G +
Sbjct: 425 -----GACVNAMDLWQ-------FTPLHEAASKNRVEVCSLLL-SHGADPTLV-NCHGKS 470
Query: 1282 PLHLAC-----------FGGH--------MSIVGLLLSRSAELLH-STDRHGKTGLH--I 1319
+ +A F GH + + + + E+++ + +T LH +
Sbjct: 471 AVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAV 530
Query: 1320 ASTH-GHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNL 1378
AS H Q+ E+LL +GA +N +K+ TPLH AA+ H +V+++L + GA + L
Sbjct: 531 ASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTL 590
Query: 1379 NCAPIWFAASENHNDVLEYLL 1399
+ AA H LL
Sbjct: 591 GQTALHRAALAGHLQTCRLLL 611
Score = 65.3 bits (152), Expect = 2e-09
Identities = 45/121 (37%), Positives = 58/121 (47%), Gaps = 4/121 (3%)
Query: 1286 ACFGGHMSIVGLLLSRSAELLHSTDRHGKTG--LHIASTHGHYQMVEVLLGQGAEINATD 1343
AC G +S V L+ A +++ D G+ LH A+ G +VE LL GA ++A D
Sbjct: 189 ACRNGDVSRVKRLVD--AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARD 246
Query: 1344 KNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEH 1403
G PLH A GH VV LL GA P + N N P+ AA + DV LL
Sbjct: 247 DGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGA 306
Query: 1404 D 1404
D
Sbjct: 307 D 307
Score = 58.4 bits (135), Expect = 3e-07
Identities = 46/151 (30%), Positives = 70/151 (46%), Gaps = 3/151 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
LL A +AG+ V++L S+Q + T LH AA V + L+ +GA V A
Sbjct: 654 LLEASKAGDLETVKQLCSSQNVN-CRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA 712
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G PLH A + G + + A+ +AD TP+H AA G I +LL K
Sbjct: 713 KDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLL-K 771
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMML 217
A ++ +DG+T + + G D +L
Sbjct: 772 HGADPTKKNRDGNTPLDLVK-EGDTDIQDLL 801
Score = 58.0 bits (134), Expect = 3e-07
Identities = 45/158 (28%), Positives = 75/158 (47%), Gaps = 4/158 (2%)
Query: 49 KEWKKLIRDLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARR 108
KE I+DL+ +G LL A + G + V++L + + + T T LHLAA
Sbjct: 791 KEGDTDIQDLL--KGDAALLDAAKKGCLARVQKLCTPENIN-CRDTQGRNSTPLHLAAGY 847
Query: 109 RDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPM 168
++++A L+++GA V+A + G PLH AA+ G + D TP+
Sbjct: 848 NNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 907
Query: 169 HLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIAS 206
H AA+ G + LL A + ++G T + +A+
Sbjct: 908 HEAAQKGRTQLCALLL-AHGADPTMKNQEGQTPLDLAT 944
Score = 54.4 bits (125), Expect = 4e-06
Identities = 39/119 (32%), Positives = 60/119 (50%), Gaps = 4/119 (3%)
Query: 105 AARRRDVDMARILVDYGAVVDATNGAGQ--TPLHIAAAEGDEPLVKYFYGVRANAAIADN 162
A R DV + LVD A V+A + AG+ +PLH AA G + +V++ + AN D+
Sbjct: 189 ACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDD 247
Query: 163 EDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
P+H A GHA ++ LL + A R T +H A++ G D ++L + G
Sbjct: 248 GGLIPLHNACSFGHAEVVSLLLCQ-GADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG 305
Score = 54.0 bits (124), Expect = 5e-06
Identities = 40/133 (30%), Positives = 62/133 (46%), Gaps = 3/133 (2%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL LA N + LL + + A G LH AA VD+A +L+ Y
Sbjct: 836 RNSTPLHLAAGYNNLEVAEYLL--EHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYN 893
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLA-AENGHAAII 180
V+AT+ TPLH AA +G L A+ + + E +TP+ LA A++ A +I
Sbjct: 894 TCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLI 953
Query: 181 ELLADKFKASIFE 193
+ + + + F+
Sbjct: 954 DAMPPEALPTCFK 966
Score = 47.2 bits (107), Expect = 6e-04
Identities = 44/146 (30%), Positives = 62/146 (42%), Gaps = 4/146 (2%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
LL A G+ S V+ L+ A K + LH AA D+ L+ GA V A
Sbjct: 186 LLEACRNGDVSRVKRLVDAANVNA-KDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHA 244
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI-IELLAD 185
+ G PLH A + G +V A+ DN + TP+H AA G + I LL
Sbjct: 245 RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 304
Query: 186 KFKASIFERTKDGSTLMHIASLNGHA 211
+I R DG + + +A + A
Sbjct: 305 GADPNI--RNTDGKSALDLADPSAKA 328
Score = 40.3 bits (90), Expect = 0.072
Identities = 26/86 (30%), Positives = 45/86 (52%), Gaps = 4/86 (4%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T LH+AA R D+ +L +GA ++A + GQT LH AA G + ++ +I
Sbjct: 560 TPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619
Query: 160 ADNEDRTPMHLAAENGHAAIIELLAD 185
+ T AA+ G+ A+ ++L++
Sbjct: 620 ISLQGFT----AAQMGNEAVQQILSE 641
Score = 39.1 bits (87), Expect = 0.17
Identities = 31/90 (34%), Positives = 43/90 (47%), Gaps = 7/90 (7%)
Query: 99 DTALHLAARR---RDVDMARILVDYGAVVDATNGAGQTPLHIAA--AEGDEPLVKYFYGV 153
+TALH A + + +L+ GA V+ N TPLH+AA A D V + +G
Sbjct: 523 ETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGA 582
Query: 154 RANAAIADNEDRTPMHLAAENGHAAIIELL 183
+ NA D +T +H AA GH LL
Sbjct: 583 KMNA--LDTLGQTALHRAALAGHLQTCRLL 610
Score = 38.3 bits (85), Expect = 0.29
Identities = 30/123 (24%), Positives = 46/123 (37%), Gaps = 1/123 (0%)
Query: 99 DTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAA 158
D L A + + +L A++G TPLH+AA +V+ A+
Sbjct: 337 DELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVH 396
Query: 159 IADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF 218
D P+H A GH + ELL K A + T +H A+ + +L
Sbjct: 397 AKDKGGLVPLHNACSYGHYEVTELLL-KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 455
Query: 219 KKG 221
G
Sbjct: 456 SHG 458
Score = 38.3 bits (85), Expect = 0.29
Identities = 22/67 (32%), Positives = 33/67 (49%), Gaps = 1/67 (1%)
Query: 155 ANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCA 214
AN + + TP+H+AAE H ++E+L K A + G T +H A+L GH
Sbjct: 549 ANVNEKNKDFMTPLHVAAERAHNDVMEVL-HKHGAKMNALDTLGQTALHRAALAGHLQTC 607
Query: 215 MMLFKKG 221
+L G
Sbjct: 608 RLLLSYG 614
>AF082557-1|AAC79842.1| 1094|Homo sapiens TRF1-interacting
ankyrin-related ADP-ribose polymerase protein.
Length = 1094
Score = 159 bits (386), Expect = 1e-37
Identities = 161/581 (27%), Positives = 256/581 (44%), Gaps = 69/581 (11%)
Query: 838 AFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYC 897
A + A D+ G LH AC EV V L+ GAD + + N+ T H
Sbjct: 7 ANVHARDDGGLIPLHNACSFGHAEV---------VSLLLCQGADPNARDNWNY-TPLHEA 56
Query: 898 AIAGNNDVMTEMIAH--------------ISTADVSRALNRQNSIGWTPLLIACHRGHMQ 943
AI G DV ++ H + AD S LL A G+ +
Sbjct: 57 AIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEE 116
Query: 944 LVNTLLTNHARVDVFDVEGRSA--LHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
+ LLT V+ +GR + LHLAA + +++ LL + A +++K + G LH
Sbjct: 117 KLMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHN 175
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A G+ + + L++ H A ++ + L + TPLH AA+ ++EVC LLL GA+ +
Sbjct: 176 ACSYGHYEVTELLLK-HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCH 234
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
G+ + A E + + H L A D +A ++ ++ + E++ F
Sbjct: 235 GKSAVDMAPTPELRERLTYEFKGHSLLQAAREAD------LAKVKKTLAL--EIINF--- 283
Query: 1122 GVISARNKLNDSTPLQLAAEGGHA---DVVRVLVRAGASCTDENRAGLTAVHLAAEHGHT 1178
+ + T L A H V +L+R GA+ ++N+ +T +H+AAE H
Sbjct: 284 -----KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHN 338
Query: 1179 NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPV 1238
+V++V+ + LG T LH AA G +T R LLS+ P+ +SL
Sbjct: 339 DVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSY------GSDPSIISL--- 389
Query: 1239 LGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLL 1298
G T AA GNE V ++L S ++ +++ Y L + G ++ L
Sbjct: 390 ----QGFT----AAQMGNEAVQQILSESTPIR----TSDVDYRLLEASKAGDLETVKQLC 437
Query: 1299 LSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGH 1358
S++ RH T LH A+ + +VE LL GA+++A DK G PLH A GH
Sbjct: 438 SSQNVNCRDLEGRHS-TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGH 496
Query: 1359 LNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
V +LL GAS P+ AA++ ++ + LL
Sbjct: 497 YEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLL 537
Score = 153 bits (370), Expect = 9e-36
Identities = 195/754 (25%), Positives = 307/754 (40%), Gaps = 81/754 (10%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H A +GH +++ LL +G + N NYT LH A K V LL +GAD
Sbjct: 16 GLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADP 75
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+IR DG K AL L A E + AA+ GN L+
Sbjct: 76 NIRN--------------TDG-KSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMA 120
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL PL C TPL +A IV+ L++ D + A
Sbjct: 121 LLT----PLNVN--CHASDGRKSTPLHLAAGYNRVRIVQLLLQHGAD----------VHA 164
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
D+ G LH AC EV + L+++GA V+ T H A
Sbjct: 165 KDKGGLVPLHNACSYGHYEV---------TELLLKHGACVNAMDLWQF-TPLHEAASKNR 214
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPL------LIACHRGHMQLVNTLLTNHARV- 955
+V + +++H + + + ++++ P L +GH L + A+V
Sbjct: 215 VEVCSLLLSHGADPTLVNC-HGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVK 273
Query: 956 -----DVFDVEG----RSALHLAAEHGY---LQVCDALLTNKAFINSKARNGRTALHLAA 1003
++ + + +ALH A + QV + LL A +N K ++ T LH+AA
Sbjct: 274 KTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAA 333
Query: 1004 MNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQ 1063
+ +++ L + H A ++ L QT LH AA +G ++ C+LLL G++ G
Sbjct: 334 ERAHNDVMEVLHK-HGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQG- 391
Query: 1064 KPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGV 1123
AAQ V Q+ + P T D + A+ G ++ +++L
Sbjct: 392 ---FTAAQMGNEAVQQILSESTP----IRTSDVDYRLLEASKAGDLETVKQLCSSQNVNC 444
Query: 1124 ISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDV 1183
+ STPL AA VV L+ GA +++ GL +H A +GH V ++
Sbjct: 445 RDLEGR--HSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAEL 502
Query: 1184 MRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKS--EAPTGVSLVP---- 1237
+ + TPLH AA G+ E + LL H K + T + LV
Sbjct: 503 LVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDT 562
Query: 1238 -VLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVG 1296
+ G L AA G V+ L + N PLHLA ++ +
Sbjct: 563 DIQDLLKGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNS-TPLHLAAGYNNLEVAE 621
Query: 1297 LLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKA 1356
LL A++ ++ D+ G LH A+++GH + +L+ +NATDK +TPLH AA+
Sbjct: 622 YLLEHGADV-NAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQK 680
Query: 1357 GHLNVVKLLCESGASPKSETNLNCAPIWFAASEN 1390
G + LL GA P + P+ A +++
Sbjct: 681 GRTQLCALLLAHGADPTMKNQEGQTPLDLATADD 714
Score = 120 bits (288), Expect = 7e-26
Identities = 163/596 (27%), Positives = 251/596 (42%), Gaps = 73/596 (12%)
Query: 662 DGARS--IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYG 719
DG +S +H AA Y V I+ LLQ G V LH A V E LL +G
Sbjct: 133 DGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHG 192
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAA------- 772
A V+ Q TPLH AA + C+L LL GA P G + V +A
Sbjct: 193 ACVNAMDLWQ-FTPLHEAASKNRVEVCSL-LLSHGADPTLVNCHGKSAVDMAPTPELRER 250
Query: 773 ---KFGNLATLVLLLEDGGDPLRKTK----VCIYDVVTGETPLQMACRSCMPDIVRHLIE 825
+F + L E ++KT + + ET L A S P R +
Sbjct: 251 LTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPK--RKQVT 308
Query: 826 FVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV-SL 884
+ KG +V+ ++D + LH A + A V++ L ++GA + +L
Sbjct: 309 ELLLRKGANVNEK-----NKDFMTPLHVAAE---------RAHNDVMEVLHKHGAKMNAL 354
Query: 885 QTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQL 944
T +TA H A+AG H+ T + + SI A G+ +
Sbjct: 355 DTL--GQTALHRAALAG----------HLQTCRLLLSYGSDPSIISLQGFTAAQMGN-EA 401
Query: 945 VNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGR--TALHLA 1002
V +L+ + DV+ R L A++ G L+ L +++ +N + GR T LH A
Sbjct: 402 VQQILSESTPIRTSDVDYR--LLEASKAGDLETVKQLCSSQN-VNCRDLEGRHSTPLHFA 458
Query: 1003 AMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELG 1062
A +V++L+ H A + PLH A + G EV +LL+ GA+++ D
Sbjct: 459 AGYNRVSVVEYLLH-HGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 517
Query: 1063 QKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA-----IQGSVKVIEELMK 1117
P+H AA E+ +L L +H +DGNT + IQ +K L+
Sbjct: 518 FTPLHEAAAKGKYEICKLLL-KHGADPTKKNRDGNTPLDLVKEGDTDIQDLLKGDAALLD 576
Query: 1118 FDRTGVISARNKL-------------NDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
+ G ++ KL +STPL LAA + +V L+ GA +++
Sbjct: 577 AAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKG 636
Query: 1165 GLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSH 1220
GL +H AA +GH ++ ++ NT ++ K TPLH AA G+ + LL+H
Sbjct: 637 GLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAH 692
Score = 113 bits (273), Expect = 5e-24
Identities = 145/518 (27%), Positives = 216/518 (41%), Gaps = 52/518 (10%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G PL AC GH ++V+ LL A + D + LH AA G + VC LL + A
Sbjct: 16 GLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADP 75
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N + +G++AL LA + A L KK L A + + ++ LL
Sbjct: 76 NIRNTDGKSALDLADPSAKAVLTG-------------EYKKDELLEAARSGNEEKLMALL 122
Query: 1049 LELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGS 1108
L N A+D P+H AA N +VQL LQ H V A K G H A G
Sbjct: 123 TPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQ-HGADVHAKDKGGLVPLHNACSYGH 181
Query: 1109 VKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTA 1168
+V E L+K ++A + L TPL AA +V +L+ GA T N G +A
Sbjct: 182 YEVTELLLKHG--ACVNAMD-LWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSA 238
Query: 1169 VHLAAE-----------HGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVREL 1217
V +A GH+ +L R + ++ K L L ++ + Q ++
Sbjct: 239 VDMAPTPELRERLTYEFKGHS-LLQAAREADLAKVK-KTLALEIIN----FKQPQSHETA 292
Query: 1218 LSHVPGTVKSEAPTGVSLVPVLGAESG------LTPLHLAAYNGNENVVRLLLNSAGVQA 1271
L ++ + L+ GA +TPLH+AA + +V+ +L + G +
Sbjct: 293 LHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVL-HKHGAKM 351
Query: 1272 DAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEV 1331
+A G LH A GH+ LLLS ++ G T + + + V+
Sbjct: 352 NALDTL-GQTALHRAALAGHLQTCRLLLSYGSDP-SIISLQGFTAAQMGN-----EAVQQ 404
Query: 1332 LLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCES-GASPKSETNLNCAPIWFAASEN 1390
+L + I +D + L A+KAG L VK LC S + + + P+ FAA N
Sbjct: 405 ILSESTPIRTSDVD--YRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYN 462
Query: 1391 HNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNI 1428
V+EYLLH D + D V CS H +
Sbjct: 463 RVSVVEYLLHHGADVHA-KDKGGLVPLHNACSYGHYEV 499
Score = 105 bits (252), Expect = 2e-21
Identities = 78/237 (32%), Positives = 110/237 (46%), Gaps = 12/237 (5%)
Query: 1151 LVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQ 1210
L++ GA+ + GL +H A GH V+ ++ + TPLH AA G+
Sbjct: 2 LLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGK 61
Query: 1211 AETVRELLSHV--PGTVKSEAPTGVSLVP-----VLGAESGLTPLHLAAYNGNENVVRLL 1263
+ LL H P ++ + + L VL E L AA +GNE + L
Sbjct: 62 IDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMAL 121
Query: 1264 LNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTH 1323
L V A+ PLHLA + IV LLL A++ H+ D+ G LH A ++
Sbjct: 122 LTPLNVNCHASDGRKS-TPLHLAAGYNRVRIVQLLLQHGADV-HAKDKGGLVPLHNACSY 179
Query: 1324 GHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNC 1380
GHY++ E+LL GA +NA D +TPLH AA + V LL GA P T +NC
Sbjct: 180 GHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADP---TLVNC 233
Score = 77.4 bits (182), Expect = 5e-13
Identities = 105/395 (26%), Positives = 162/395 (41%), Gaps = 61/395 (15%)
Query: 1048 LLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ--HPNLVMATTKDGNTCAHIAAI 1105
LL++GAN+ A D+ G P+H A ++EVV L L Q PN A T H AAI
Sbjct: 2 LLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPN---ARDNWNYTPLHEAAI 58
Query: 1106 QGSVKVIEELMKFDRTGVI---SARNKLNDSTP---------------LQLAAEGGHADV 1147
+G + V L++ I ++ L+ + P L+ A G +
Sbjct: 59 KGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKL 118
Query: 1148 VRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAY 1207
+ +L +C + T +HLAA + ++ ++ + K GL PLH A
Sbjct: 119 MALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACS 178
Query: 1208 YGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSA 1267
YG E LL H + L TPLH AA V LLL S
Sbjct: 179 YGHYEVTELLLKH------GACVNAMDLWQ-------FTPLHEAASKNRVEVCSLLL-SH 224
Query: 1268 GVQADAASNENGYNPLHLAC-----------FGGH--------MSIVGLLLSRSAELLH- 1307
G N +G + + +A F GH + + + + E+++
Sbjct: 225 GADPTLV-NCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINF 283
Query: 1308 STDRHGKTGLH--IASTH-GHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKL 1364
+ +T LH +AS H Q+ E+LL +GA +N +K+ TPLH AA+ H +V+++
Sbjct: 284 KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEV 343
Query: 1365 LCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
L + GA + L + AA H LL
Sbjct: 344 LHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLL 378
Score = 58.4 bits (135), Expect = 3e-07
Identities = 46/151 (30%), Positives = 70/151 (46%), Gaps = 3/151 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
LL A +AG+ V++L S+Q + T LH AA V + L+ +GA V A
Sbjct: 421 LLEASKAGDLETVKQLCSSQNVN-CRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA 479
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G PLH A + G + + A+ +AD TP+H AA G I +LL K
Sbjct: 480 KDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLL-K 538
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMML 217
A ++ +DG+T + + G D +L
Sbjct: 539 HGADPTKKNRDGNTPLDLVK-EGDTDIQDLL 568
Score = 58.0 bits (134), Expect = 3e-07
Identities = 45/158 (28%), Positives = 75/158 (47%), Gaps = 4/158 (2%)
Query: 49 KEWKKLIRDLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARR 108
KE I+DL+ +G LL A + G + V++L + + + T T LHLAA
Sbjct: 558 KEGDTDIQDLL--KGDAALLDAAKKGCLARVQKLCTPENIN-CRDTQGRNSTPLHLAAGY 614
Query: 109 RDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPM 168
++++A L+++GA V+A + G PLH AA+ G + D TP+
Sbjct: 615 NNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 674
Query: 169 HLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIAS 206
H AA+ G + LL A + ++G T + +A+
Sbjct: 675 HEAAQKGRTQLCALLL-AHGADPTMKNQEGQTPLDLAT 711
Score = 54.0 bits (124), Expect = 5e-06
Identities = 40/133 (30%), Positives = 62/133 (46%), Gaps = 3/133 (2%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL LA N + LL + + A G LH AA VD+A +L+ Y
Sbjct: 603 RNSTPLHLAAGYNNLEVAEYLL--EHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYN 660
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLA-AENGHAAII 180
V+AT+ TPLH AA +G L A+ + + E +TP+ LA A++ A +I
Sbjct: 661 TCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLI 720
Query: 181 ELLADKFKASIFE 193
+ + + + F+
Sbjct: 721 DAMPPEALPTCFK 733
Score = 52.0 bits (119), Expect = 2e-05
Identities = 30/73 (41%), Positives = 35/73 (47%)
Query: 1332 LLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENH 1391
LL GA ++A D G PLH A GH VV LL GA P + N N P+ AA +
Sbjct: 2 LLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGK 61
Query: 1392 NDVLEYLLHKEHD 1404
DV LL D
Sbjct: 62 IDVCIVLLQHGAD 74
Score = 40.3 bits (90), Expect = 0.072
Identities = 26/86 (30%), Positives = 45/86 (52%), Gaps = 4/86 (4%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T LH+AA R D+ +L +GA ++A + GQT LH AA G + ++ +I
Sbjct: 327 TPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 386
Query: 160 ADNEDRTPMHLAAENGHAAIIELLAD 185
+ T AA+ G+ A+ ++L++
Sbjct: 387 ISLQGFT----AAQMGNEAVQQILSE 408
Score = 39.1 bits (87), Expect = 0.17
Identities = 31/90 (34%), Positives = 43/90 (47%), Gaps = 7/90 (7%)
Query: 99 DTALHLAARR---RDVDMARILVDYGAVVDATNGAGQTPLHIAA--AEGDEPLVKYFYGV 153
+TALH A + + +L+ GA V+ N TPLH+AA A D V + +G
Sbjct: 290 ETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGA 349
Query: 154 RANAAIADNEDRTPMHLAAENGHAAIIELL 183
+ NA D +T +H AA GH LL
Sbjct: 350 KMNA--LDTLGQTALHRAALAGHLQTCRLL 377
Score = 38.3 bits (85), Expect = 0.29
Identities = 30/123 (24%), Positives = 46/123 (37%), Gaps = 1/123 (0%)
Query: 99 DTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAA 158
D L A + + +L A++G TPLH+AA +V+ A+
Sbjct: 104 DELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVH 163
Query: 159 IADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF 218
D P+H A GH + ELL K A + T +H A+ + +L
Sbjct: 164 AKDKGGLVPLHNACSYGHYEVTELLL-KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 222
Query: 219 KKG 221
G
Sbjct: 223 SHG 225
Score = 38.3 bits (85), Expect = 0.29
Identities = 22/67 (32%), Positives = 33/67 (49%), Gaps = 1/67 (1%)
Query: 155 ANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCA 214
AN + + TP+H+AAE H ++E+L K A + G T +H A+L GH
Sbjct: 316 ANVNEKNKDFMTPLHVAAERAHNDVMEVL-HKHGAKMNALDTLGQTALHRAALAGHLQTC 374
Query: 215 MMLFKKG 221
+L G
Sbjct: 375 RLLLSYG 381
Score = 36.7 bits (81), Expect = 0.89
Identities = 30/96 (31%), Positives = 43/96 (44%), Gaps = 3/96 (3%)
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+ GA V A + G PLH A + G +V A+ DN + TP+H AA G
Sbjct: 2 LLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGK 61
Query: 177 AAI-IELLADKFKASIFERTKDGSTLMHIASLNGHA 211
+ I LL +I R DG + + +A + A
Sbjct: 62 IDVCIVLLQHGADPNI--RNTDGKSALDLADPSAKA 95
>AK000295-1|BAA91063.1| 686|Homo sapiens protein ( Homo sapiens cDNA
FLJ20288 fis, clone HEP04414. ).
Length = 686
Score = 159 bits (385), Expect = 1e-37
Identities = 162/574 (28%), Positives = 255/574 (44%), Gaps = 45/574 (7%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVH------ 723
A++ GH+ ++ LL G +V TT TAL A E+ V + LL GAD+
Sbjct: 3 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 62
Query: 724 -----IRGGKQRE-------TPLHIAARIPDGDKCALM-LLKSGAGPNKATEDG-MTPVH 769
I K +E TPL AAR G C + L+ GA N+AT + T V
Sbjct: 63 TILEGIDPAKHQEHESEGGRTPLMKAARA--GHLCTVQFLISKGANVNRATANNDHTVVS 120
Query: 770 VAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKD 829
+A G+LA + LLL G DP + K G T L A + ++V +L+++ +
Sbjct: 121 LACAGGHLAVVELLLAHGADPTHRLK-------DGSTMLIEAAKGGHTNVVSYLLDYPNN 173
Query: 830 HKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHN 889
SV T + + + ++E ++ V + G++ S QT
Sbjct: 174 VL--SVPTTDVSQLPPPSQDQSQEPDRTSQENSPALLGVQKAVSTRVPTGSNSSSQTTEC 231
Query: 890 HETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLL 949
C+ +N M + DV + T L +AC GH +LV+ L+
Sbjct: 232 LTP--ESCSQTTSNVASQSMPPVYPSVDVDAHTESNHD---TALTLACAGGHEELVSVLI 286
Query: 950 TNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKA-RNGRTALHLAAMNGYA 1008
A+++ D +G + L LAA G++ V + LL I +++ R T L LA G
Sbjct: 287 ARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQ 346
Query: 1009 HLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDAT--DELGQKPI 1066
+V L+ A + + TPL LAA+ G + + K+LL GA I++ +LG P+
Sbjct: 347 EVVDLLLA-RGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPL 405
Query: 1067 HAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISA 1126
AA N + V+L L ++ + NT +A QG +V+ L+ DR +
Sbjct: 406 MLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLL--DRKANVEH 463
Query: 1127 RNKLNDSTPLQLAAEGGHADVVRVLVRAGA--SCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
R K TPL AA GG+A+V RVL+ GA + + TA+ +AA+ GH +++
Sbjct: 464 RAK-TGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 522
Query: 1185 RSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
K G TPL +A+ G + V+ L+
Sbjct: 523 IHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLV 556
Score = 143 bits (347), Expect = 5e-33
Identities = 122/430 (28%), Positives = 207/430 (48%), Gaps = 33/430 (7%)
Query: 1054 NIDA-TDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVI 1112
++DA T+ + A + E+V + + + + K G T +AA G V V+
Sbjct: 257 DVDAHTESNHDTALTLACAGGHEELVSVLIARDAK-IEHRDKKGFTPLILAATAGHVGVV 315
Query: 1113 EELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA 1172
E L+ D+ G I A+++ TPL LA GG +VV +L+ GA+ N + T + LA
Sbjct: 316 EILL--DKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 373
Query: 1173 AEHGHTNVLDVMRSTNTLRISSK---KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEA 1229
A G+ N++ ++ + I+S+ KLG++PL +AA G V+ LL + + ++
Sbjct: 374 ASGGYVNIIKILLNAGA-EINSRTGSKLGISPLMLAAMNGHVPAVKLLLD-MGSDINAQI 431
Query: 1230 PTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLN-SAGVQADAASNENGYNPLHLACF 1288
T + T L LA + G VV LLL+ A V+ A + G PL A
Sbjct: 432 ETNRN-----------TALTLACFQGRAEVVSLLLDRKANVEHRA---KTGLTPLMEAAS 477
Query: 1289 GGHMSIVGLLLSRSAEL-LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGW 1347
GG+ + +LL + A++ T L IA+ GHY+ E+L+ +GA I+ +K G
Sbjct: 478 GGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGN 537
Query: 1348 TPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
TPL A+ GH +VV+LL ++GA + N P+ A + H V++YL+ + + S
Sbjct: 538 TPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPS 597
Query: 1408 LMDDKRFVYNLM---VCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIY---INLSTKEKER 1461
++ R++ + + K H +E V A K ++I ++L +E
Sbjct: 598 DIECMRYIATITDKELLKKCHQ--CVETIVKAKDQQAAEANKNASILLKELDLEKSREES 655
Query: 1462 AKDLIAAGKQ 1471
K +AA ++
Sbjct: 656 RKQALAAKRE 665
Score = 128 bits (308), Expect = 3e-28
Identities = 117/425 (27%), Positives = 190/425 (44%), Gaps = 31/425 (7%)
Query: 1036 AAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV----MA 1091
A+ G +E+ K LL GAN+ AT G + A +N +++V + LQ +L M
Sbjct: 3 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 62
Query: 1092 T--------------TKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
T ++ G T AA G + ++ L+ + ++ ND T +
Sbjct: 63 TILEGIDPAKHQEHESEGGRTPLMKAARAGHLCTVQFLIS--KGANVNRATANNDHTVVS 120
Query: 1138 LAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRS--TNTLRISSK 1195
LA GGH VV +L+ GA T + G T + AA+ GHTNV+ + N L + +
Sbjct: 121 LACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTT 180
Query: 1196 KLGLTPLHIAAYYGQAETVRE----LLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLA 1251
+ P + + + L V V + PTG + LTP +
Sbjct: 181 DVSQLPPPSQDQSQEPDRTSQENSPALLGVQKAVSTRVPTGSNSSSQ--TTECLTPESCS 238
Query: 1252 AYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDR 1311
N + V DA + N L LAC GGH +V +L++R A++ H D+
Sbjct: 239 QTTSNVASQSMPPVYPSVDVDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEH-RDK 297
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQGAEINA-TDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
G T L +A+T GH +VE+LL +G +I A +++ TPL A G VV LL GA
Sbjct: 298 KGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGA 357
Query: 1371 SPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPI 1430
+ + + P+ AAS + ++++ LL+ + S K + LM+ + N ++P
Sbjct: 358 NKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN-GHVPA 416
Query: 1431 EEFVL 1435
+ +L
Sbjct: 417 VKLLL 421
Score = 87.4 bits (207), Expect = 5e-16
Identities = 91/366 (24%), Positives = 165/366 (45%), Gaps = 33/366 (9%)
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
DV +T L +A ++ +L+ A + G TP+ +AA G++ +
Sbjct: 257 DVDAHTESNHDTALTLACA-GGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 315
Query: 781 VLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFI 840
+LL+ GGD +++ T +TPL +AC ++V L+ + + +VS
Sbjct: 316 EILLDKGGDIEAQSER------TKDTPLSLACSGGRQEVVDLLLARGANKEHRNVS---- 365
Query: 841 DAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIA 900
D A++ Y ++K L+ GA+++ +T + A
Sbjct: 366 DYTPLSLAASGGYV---------------NIIKILLNAGAEINSRTGSKLGISPLMLAAM 410
Query: 901 GNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDV 960
+ +++ + + D++ + + T L +AC +G ++V+ LL A V+
Sbjct: 411 NGHVPAVKLLLDMGS-DINAQIETNRN---TALTLACFQGRAEVVSLLLDRKANVEHRAK 466
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKA--RNGRTALHLAAMNGYAHLVKFLIRDH 1018
G + L AA GY +V LL A +N+ + TAL +AA G+ + LI
Sbjct: 467 TGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIH-R 525
Query: 1019 NAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVV 1078
A IDV K TPL LA+ G +V +LL++ GA++DA D P+ +A + + +VV
Sbjct: 526 GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVV 585
Query: 1079 QLFLQQ 1084
Q +++
Sbjct: 586 QYLVKE 591
Score = 73.7 bits (173), Expect = 6e-12
Identities = 81/346 (23%), Positives = 147/346 (42%), Gaps = 29/346 (8%)
Query: 674 GHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETP 733
GH +++ L+ + ++ +T L +A + VVE LL G D+ + + ++TP
Sbjct: 277 GHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTP 336
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L +A + +LL GA TP+ +AA G + + +LL G + +
Sbjct: 337 LSLACS-GGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR 395
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHY 853
T + G +PL +A + V+ L++ D + ++ + +AL
Sbjct: 396 TGSKL-----GISPLMLAAMNGHVPAVKLLLDMGSDINAQ---------IETNRNTALTL 441
Query: 854 ACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHI 913
AC + EV DR K +E+ A L E A A G V+ + A +
Sbjct: 442 ACFQGRAEVVSLLLDR---KANVEHRAKTGLTPLM--EAASGGYAEVGR--VLLDKGADV 494
Query: 914 STADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHG 973
+ V + + T L IA +GH + L+ A +DV + +G + L LA+ G
Sbjct: 495 NAPPVPSSRD-------TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGG 547
Query: 974 YLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
+ V L+ A +++ T L A G+ +V++L+++ N
Sbjct: 548 HFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVN 593
Score = 62.1 bits (144), Expect = 2e-08
Identities = 48/158 (30%), Positives = 77/158 (48%), Gaps = 6/158 (3%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G++ +V L++ +++ G T L LAA V + IL+D G ++A
Sbjct: 270 LTLACAGGHEELVSVLIARDA--KIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 327
Query: 127 -TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ TPL +A + G + +V AN + D TP+ LAA G+ II++L +
Sbjct: 328 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 387
Query: 186 KFKASIFERT--KDGSTLMHIASLNGHADCAMMLFKKG 221
A I RT K G + + +A++NGH +L G
Sbjct: 388 A-GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG 424
Score = 59.3 bits (137), Expect = 1e-07
Identities = 54/169 (31%), Positives = 76/169 (44%), Gaps = 25/169 (14%)
Query: 70 AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNG 129
A + G+ +V+ LL++ + ATT GDTAL A D+A +L+ GA +D
Sbjct: 3 ASQEGHLELVKYLLAS--GANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQED 60
Query: 130 -------------------AGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPM 168
G+TPL AA G V++ G N A A+N D T +
Sbjct: 61 MKTILEGIDPAKHQEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN-DHTVV 119
Query: 169 HLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
LA GH A++ELL A R KDGST++ A+ GH + L
Sbjct: 120 SLACAGGHLAVVELLL-AHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 167
Score = 59.3 bits (137), Expect = 1e-07
Identities = 36/121 (29%), Positives = 53/121 (43%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL+ A G + R LL + DTAL +AA + +L+ GA
Sbjct: 468 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGA 527
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+D N G TPL +A+ G +V+ A+ ADN TP+ A GH +++
Sbjct: 528 HIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQY 587
Query: 183 L 183
L
Sbjct: 588 L 588
Score = 58.0 bits (134), Expect = 3e-07
Identities = 50/161 (31%), Positives = 75/161 (46%), Gaps = 4/161 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL+LA G+ V+ LL + + T +TAL LA + ++ +L+D A
Sbjct: 401 GISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR-NTALTLACFQGRAEVVSLLLDRKA 459
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPMHLAAENGHAAII 180
V+ G TPL AA+ G + + G NA + T + +AA+ GH
Sbjct: 460 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 519
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
ELL + A I R K G+T + +AS GH D +L + G
Sbjct: 520 ELLIHR-GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAG 559
Score = 56.8 bits (131), Expect = 8e-07
Identities = 43/162 (26%), Positives = 75/162 (46%), Gaps = 3/162 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL+LA AG+ +V E+L + + + DT L LA ++ +L+
Sbjct: 297 KKGFTPLILAATAGHVGVV-EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLAR 355
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPMHLAAENGHAA 178
GA + N + TPL +AA+ G ++K G N+ +P+ LAA NGH
Sbjct: 356 GANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVP 415
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
++LL D + + +T + +A G A+ +L +
Sbjct: 416 AVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDR 457
Score = 55.2 bits (127), Expect = 2e-06
Identities = 45/168 (26%), Positives = 77/168 (45%), Gaps = 6/168 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G ++++ LL+A + + G + L LAA V ++L+D G+ ++
Sbjct: 369 PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDIN 428
Query: 126 ATNGAGQ-TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A + T L +A +G +V +AN TP+ AA G+A + +L
Sbjct: 429 AQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 488
Query: 185 DK---FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
DK A ++D T + IA+ GH +L +G ++ + NK
Sbjct: 489 DKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIHRGAHIDVRNK 534
Score = 45.2 bits (102), Expect = 0.003
Identities = 35/101 (34%), Positives = 47/101 (46%), Gaps = 5/101 (4%)
Query: 124 VDA-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VDA T T L +A A G E LV A D + TP+ LAA GH ++E+
Sbjct: 258 VDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 317
Query: 183 LADKFK--ASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L DK + ERTKD T + +A G + +L +G
Sbjct: 318 LLDKGGDIEAQSERTKD--TPLSLACSGGRQEVVDLLLARG 356
Score = 42.7 bits (96), Expect = 0.014
Identities = 23/67 (34%), Positives = 39/67 (58%), Gaps = 1/67 (1%)
Query: 656 EKYKHFDGARSIHTAARYGHVGIINTLLQKGESVD-VTTNDNYTALHIAVESCKPAVVET 714
++++ G + AAR GH+ + L+ KG +V+ T N+++T + +A AVVE
Sbjct: 74 QEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVEL 133
Query: 715 LLGYGAD 721
LL +GAD
Sbjct: 134 LLAHGAD 140
Score = 41.1 bits (92), Expect = 0.041
Identities = 31/128 (24%), Positives = 58/128 (45%), Gaps = 2/128 (1%)
Query: 99 DTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRAN-A 157
DTAL LA ++ +L+ A ++ + G TPL +AA G +V+ +
Sbjct: 267 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 326
Query: 158 AIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
A ++ TP+ LA G +++LL + A+ R T + +A+ G+ + +L
Sbjct: 327 AQSERTKDTPLSLACSGGRQEVVDLLLAR-GANKEHRNVSDYTPLSLAASGGYVNIIKIL 385
Query: 218 FKKGVYLH 225
G ++
Sbjct: 386 LNAGAEIN 393
Score = 39.9 bits (89), Expect = 0.096
Identities = 44/173 (25%), Positives = 71/173 (41%), Gaps = 9/173 (5%)
Query: 674 GHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG-GKQRET 732
G +++ LL + +V+ T L A V LL GADV+ R+T
Sbjct: 446 GRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 505
Query: 733 PLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLR 792
L IAA C L L+ GA + + G TP+ +A+ G+ + LL++ G D
Sbjct: 506 ALTIAADKGHYKFCEL-LIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 564
Query: 793 KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDE 845
I TPL A R +V++L++ V + +I + +
Sbjct: 565 ADNRKI-------TPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITD 610
>AF521883-1|AAO14944.1| 2617|Homo sapiens multiple ankyrin repeats
single KH domain protein isoform 2 protein.
Length = 2617
Score = 159 bits (385), Expect = 1e-37
Identities = 145/496 (29%), Positives = 223/496 (44%), Gaps = 33/496 (6%)
Query: 936 ACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNG 995
AC G + V LL V+ EG S L LA GY ++ LL A + + G
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 996 R-TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
T L A+ GY +VK L+ H+A ++ + T L A A G +++ K+LL GAN
Sbjct: 272 DITPLMAASSGGYLDIVKLLLL-HDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 330
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
I+ +E G P+ AA + EV ++ L + + + + +A +G + ++
Sbjct: 331 IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRF 390
Query: 1115 LMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
L++ G T L A GH +V R+L+ +GA + + + LAA
Sbjct: 391 LLE---AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447
Query: 1175 HGHTNV--LDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL---SHVPGTVKSEA 1229
GH + L + R N ++ + G TPL AA G E V LL +++ +
Sbjct: 448 GGHVELAALLIERGANLEEVNDE--GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ 505
Query: 1230 PTGVSL------------VPVLGAESGL---TPLHLAAYNGNENVVRLLLNS-AGVQADA 1273
T ++L + GA+ L TPL A+ G+ +V+ LL S A V A
Sbjct: 506 ETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATT 565
Query: 1274 ASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLL 1333
A+ G L AC GH + +LL A+L H ++ G+T L A+ GH V+ L+
Sbjct: 566 AT---GDTALTYACENGHTDVADVLLQAGADLEHESE-GGRTPLMKAARAGHLCTVQFLI 621
Query: 1334 GQGAEIN-ATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHN 1392
+GA +N AT N T + A GHL VV+LL GA P + AA H
Sbjct: 622 SKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 681
Query: 1393 DVLEYLLHKEHDTQSL 1408
+V+ YLL ++ S+
Sbjct: 682 NVVSYLLDYPNNVLSV 697
Score = 144 bits (348), Expect = 4e-33
Identities = 123/430 (28%), Positives = 207/430 (48%), Gaps = 33/430 (7%)
Query: 1054 NIDA-TDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVI 1112
+IDA T+ + A + E+V + + + + K G T +AA G V V+
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAK-IEHRDKKGFTPLILAATAGHVGVV 1104
Query: 1113 EELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA 1172
E L+ D+ G I A+++ TPL LA GG +VV +L+ GA+ N + T + LA
Sbjct: 1105 EILL--DKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162
Query: 1173 AEHGHTNVLDVMRSTNTLRISSK---KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEA 1229
A G+ N++ ++ + I+S+ KLG++PL +AA G V+ LL + + ++
Sbjct: 1163 ASGGYVNIIKILLNAGA-EINSRTGSKLGISPLMLAAMNGHVPAVKLLLD-MGSDINAQI 1220
Query: 1230 PTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLN-SAGVQADAASNENGYNPLHLACF 1288
T + T L LA + G VV LLL+ A V+ A + G PL A
Sbjct: 1221 ETNRN-----------TALTLACFQGRAEVVSLLLDRKANVEHRA---KTGLTPLMEAAS 1266
Query: 1289 GGHMSIVGLLLSRSAEL-LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGW 1347
GG+ + +LL + A++ T L IA+ GHY+ E+L+ +GA I+ +K G
Sbjct: 1267 GGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGN 1326
Query: 1348 TPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
TPL A+ GH +VV+LL ++GA + N P+ A + H V++YL+ + + S
Sbjct: 1327 TPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPS 1386
Query: 1408 LMDDKRFVYNLM---VCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIY---INLSTKEKER 1461
++ R++ + + K H +E V A K ++I ++L +E
Sbjct: 1387 DIECMRYIATITDKELLKKCHQ--CVETIVKAKDQQAAEANKNASILLKELDLEKSREES 1444
Query: 1462 AKDLIAAGKQ 1471
K +AA ++
Sbjct: 1445 RKQALAAKRE 1454
Score = 142 bits (344), Expect = 1e-32
Identities = 150/521 (28%), Positives = 236/521 (45%), Gaps = 41/521 (7%)
Query: 665 RSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHI 724
RS+ A G V + LL +G SV+ T + + L +A + + + LL A+V
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 266
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLL 784
RG K TPL A+ D L+LL A N + G T + A G + + +LL
Sbjct: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHD-ADVNSQSATGNTALTYACAGGFVDIVKVLL 325
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD 844
+G + + G TPL A + ++ R L+ DH G ++T +
Sbjct: 326 NEGANIEDHNE-------NGHTPLMEAASAGHVEVARVLL----DH-GAGINTHS----N 369
Query: 845 EDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNND 904
E SAL AC +V+ L+E GAD +T H C + G+ +
Sbjct: 370 EFKESALTLACY---------KGHLDMVRFLLEAGADQEHKTDEMHTALMEAC-MDGHVE 419
Query: 905 VMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRS 964
V ++ S A V+ + S PL +A GH++L L+ A ++ + EG +
Sbjct: 420 VARLLLD--SGAQVNMPADSFES----PLTLAACGGHVELAALLIERGANLEEVNDEGYT 473
Query: 965 ALHLAAEHGYLQVCDALLTNKAFINSKARNGR-TALHLAAMNGYAHLVKFLIRDHNAMID 1023
L AA G+ ++ LL A IN++ + TAL LA G++ + FLI+ A D
Sbjct: 474 PLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIK---AGAD 530
Query: 1024 VLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
+ L TPL A+ G +E+ K LL GAN+ AT G + A +N +++V + LQ
Sbjct: 531 I-ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589
Query: 1084 QHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGG 1143
+L + + G T AA G + ++ L+ + ++ ND T + LA GG
Sbjct: 590 AGADLEHES-EGGRTPLMKAARAGHLCTVQFLIS--KGANVNRATANNDHTVVSLACAGG 646
Query: 1144 HADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
H VV +L+ GA T + G T + AA+ GHTNV+ +
Sbjct: 647 HLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687
Score = 120 bits (289), Expect = 6e-26
Identities = 92/293 (31%), Positives = 145/293 (49%), Gaps = 9/293 (3%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
T L +AC GH +LV+ L+ A+++ D +G + L LAA G++ V + LL I +
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 991 KA-RNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL 1049
++ R T L LA G +V L+ A + + TPL LAA+ G + + K+LL
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLA-RGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
Query: 1050 ELGANIDAT--DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQG 1107
GA I++ +LG P+ AA N + V+L L ++ + NT +A QG
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
Query: 1108 SVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGA--SCTDENRAG 1165
+V+ L+ DR + R K TPL AA GG+A+V RVL+ GA + +
Sbjct: 1236 RAEVVSLLL--DRKANVEHRAK-TGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1292
Query: 1166 LTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
TA+ +AA+ GH +++ K G TPL +A+ G + V+ L+
Sbjct: 1293 DTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLV 1345
Score = 114 bits (274), Expect = 4e-24
Identities = 115/433 (26%), Positives = 188/433 (43%), Gaps = 36/433 (8%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A G V I+ LL +G +++ + +T L A + V LL +GA +
Sbjct: 305 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 364
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + +E+ L +A D LL++GA T++ T + A G++ L
Sbjct: 365 NTHSNEFKESALTLACYKGHLDMVRF-LLEAGADQEHKTDEMHTALMEACMDGHVEVARL 423
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL+ G + E+PL +A ++ LIE +G A ++
Sbjct: 424 LLDSGAQVNMPAD-------SFESPLTLAACGGHVELAALLIE-----RG-----ANLEE 466
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
V+++G + L A + EE+ V L+ GA+++ QT ETA G
Sbjct: 467 VNDEGYTPLMEAAREGHEEM---------VALLLAQGANINAQTEETQETALTLACCGGF 517
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
++V +I + AD+ + TPL+ A GH++LV LL + A V G
Sbjct: 518 SEVADFLIK--AGADIELGCS-------TPLMEASQEGHLELVKYLLASGANVHATTATG 568
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+AL A E+G+ V D LL A + ++ GRT L AA G+ V+FLI +
Sbjct: 569 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVN 628
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
T + LA A G + V +LLL GA+ + G + AA+ ++ VV L
Sbjct: 629 RATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
Query: 1083 QQHPNLVMATTKD 1095
N++ T D
Sbjct: 689 DYPNNVLSVPTTD 701
Score = 114 bits (274), Expect = 4e-24
Identities = 98/346 (28%), Positives = 162/346 (46%), Gaps = 15/346 (4%)
Query: 881 DVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRG 940
D+ T NH+TA G+ ++++ +IA + ++ G+TPL++A G
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIAR------DAKIEHRDKKGFTPLILAATAG 1099
Query: 941 HMQLVNTLLTNHARVDVFDVEGR-SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTAL 999
H+ +V LL ++ + + L LA G +V D LL A + + T L
Sbjct: 1100 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPL 1159
Query: 1000 HLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQ--TPLHLAAASGQIEVCKLLLELGANIDA 1057
LAA GY +++K L+ + A I+ T K +PL LAA +G + KLLL++G++I+A
Sbjct: 1160 SLAASGGYVNIIKILL-NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINA 1218
Query: 1058 TDELGQK-PIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
E + + A +EVV L L + N V K G T AA G +V L+
Sbjct: 1219 QIETNRNTALTLACFQGRAEVVSLLLDRKAN-VEHRAKTGLTPLMEAASGGYAEVGRVLL 1277
Query: 1117 KFDRTGVISARN-KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEH 1175
D+ ++A + T L +AA+ GH +L+ GA N+ G T + LA+
Sbjct: 1278 --DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNG 1335
Query: 1176 GHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
GH +V+ ++ ++ +TPL A G + V+ L+ V
Sbjct: 1336 GHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEV 1381
Score = 90.6 bits (215), Expect = 5e-17
Identities = 66/226 (29%), Positives = 109/226 (48%), Gaps = 5/226 (2%)
Query: 1211 AETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQ 1270
A+T+ + L + V + PTG + LTP + N + V
Sbjct: 989 AQTLTDTLDDLIAAVSTRVPTGSNSSSQ--TTECLTPESCSQTTSNVASQSMPPVYPSVD 1046
Query: 1271 ADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVE 1330
DA + N L LAC GGH +V +L++R A++ H D+ G T L +A+T GH +VE
Sbjct: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEH-RDKKGFTPLILAATAGHVGVVE 1105
Query: 1331 VLLGQGAEINA-TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASE 1389
+LL +G +I A +++ TPL A G VV LL GA+ + + P+ AAS
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165
Query: 1390 NHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVL 1435
+ ++++ LL+ + S K + LM+ + N ++P + +L
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN-GHVPAVKLLL 1210
Score = 87.0 bits (206), Expect = 6e-16
Identities = 84/323 (26%), Positives = 151/323 (46%), Gaps = 32/323 (9%)
Query: 764 GMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHL 823
G TP+ +AA G++ + +LL+ GGD +++ T +TPL +AC ++V L
Sbjct: 1088 GFTPLILAATAGHVGVVEILLDKGGDIEAQSER------TKDTPLSLACSGGRQEVVDLL 1141
Query: 824 IEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVS 883
+ + + +VS D A++ Y ++K L+ GA+++
Sbjct: 1142 LARGANKEHRNVS----DYTPLSLAASGGYV---------------NIIKILLNAGAEIN 1182
Query: 884 LQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQ 943
+T + A + +++ + + D++ + + T L +AC +G +
Sbjct: 1183 SRTGSKLGISPLMLAAMNGHVPAVKLLLDMGS-DINAQIETNRN---TALTLACFQGRAE 1238
Query: 944 LVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKA--RNGRTALHL 1001
+V+ LL A V+ G + L AA GY +V LL A +N+ + TAL +
Sbjct: 1239 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1298
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
AA G+ + LI A IDV K TPL LA+ G +V +LL++ GA++DA D
Sbjct: 1299 AADKGHYKFCELLIH-RGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQ 1084
P+ +A + + +VVQ +++
Sbjct: 1358 KITPLMSAFRKGHVKVVQYLVKE 1380
Score = 80.2 bits (189), Expect = 7e-14
Identities = 55/154 (35%), Positives = 80/154 (51%), Gaps = 6/154 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL+ A + G+ +V+ LL++ + ATT GDTAL A D+A +L+ GA ++
Sbjct: 538 PLMEASQEGHLELVKYLLAS--GANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 595
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
+ G+TPL AA G V++ G N A A+N D T + LA GH A++ELL
Sbjct: 596 HESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN-DHTVVSLACAGGHLAVVELL 654
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
A R KDGST++ A+ GH + L
Sbjct: 655 L-AHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687
Score = 73.7 bits (173), Expect = 6e-12
Identities = 81/346 (23%), Positives = 147/346 (42%), Gaps = 29/346 (8%)
Query: 674 GHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETP 733
GH +++ L+ + ++ +T L +A + VVE LL G D+ + + ++TP
Sbjct: 1066 GHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTP 1125
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L +A + +LL GA TP+ +AA G + + +LL G + +
Sbjct: 1126 LSLACS-GGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR 1184
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHY 853
T + G +PL +A + V+ L++ D + ++ + +AL
Sbjct: 1185 TGSKL-----GISPLMLAAMNGHVPAVKLLLDMGSDINAQ---------IETNRNTALTL 1230
Query: 854 ACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHI 913
AC + EV DR K +E+ A L E A A G V+ + A +
Sbjct: 1231 ACFQGRAEVVSLLLDR---KANVEHRAKTGLTPLM--EAASGGYAEVGR--VLLDKGADV 1283
Query: 914 STADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHG 973
+ V + + T L IA +GH + L+ A +DV + +G + L LA+ G
Sbjct: 1284 NAPPVPSSRD-------TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGG 1336
Query: 974 YLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
+ V L+ A +++ T L A G+ +V++L+++ N
Sbjct: 1337 HFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVN 1382
Score = 70.5 bits (165), Expect = 6e-11
Identities = 98/381 (25%), Positives = 164/381 (43%), Gaps = 44/381 (11%)
Query: 611 VPTELLPIIWKPISKDSFYTLNIDTAMELK-SGFFEDRMIFWDTFFEKYKHFD--GARSI 667
V ++ +P ++ + D+ N DTA+ L +G E+ + K +H D G +
Sbjct: 1033 VASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPL 1092
Query: 668 HTAARYGHVGIINTLLQKGESVDV-TTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
AA GHVG++ LL KG ++ + T L +A + VV+ LL GA+ R
Sbjct: 1093 ILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRN 1152
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNLATLVLLL 784
TPL +AA +LL +GA N T G++P+ +AA G++ + LLL
Sbjct: 1153 VSD-YTPLSLAAS-GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 1210
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVK--DHKGESVSTAFIDA 842
+ G D + + T L +AC ++V L++ +H+ ++ T ++A
Sbjct: 1211 DMGSDINAQIE------TNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEA 1264
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSL-QTRHNHETAFHYCAIAG 901
G A +V + L++ GADV+ + +TA A G
Sbjct: 1265 A--SGGYA-------------------EVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1303
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ +I + DV +N G TPL +A + GH +V L+ A VD D
Sbjct: 1304 HYKFCELLIHRGAHIDV------RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357
Query: 962 GRSALHLAAEHGYLQVCDALL 982
+ L A G+++V L+
Sbjct: 1358 KITPLMSAFRKGHVKVVQYLV 1378
Score = 64.1 bits (149), Expect = 5e-09
Identities = 46/172 (26%), Positives = 82/172 (47%), Gaps = 3/172 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G + L+A +G + +LL A+ + + + G+TAL A VD+ ++L++ G
Sbjct: 270 KGDITPLMAASSGGYLDIVKLLLLHDAD-VNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAAENGHAAII 180
A ++ N G TPL AA+ G + + A NE + + + LA GH ++
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFE 232
L + A +T + T + A ++GH + A +L G ++MP FE
Sbjct: 389 RFLLEA-GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
Score = 62.1 bits (144), Expect = 2e-08
Identities = 51/161 (31%), Positives = 79/161 (49%), Gaps = 4/161 (2%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G+ MVR LL A ++ K T TAL A V++AR+L+D GA V+
Sbjct: 376 LTLACYKGHLDMVRFLLEAGADQEHK--TDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ ++PL +AA G L AN ++E TP+ AA GH ++ LL +
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Query: 187 FKASIFERTKD-GSTLMHIASLNGHADCAMMLFKKGVYLHM 226
A+I +T++ T + +A G ++ A L K G + +
Sbjct: 494 -GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL 533
Score = 62.1 bits (144), Expect = 2e-08
Identities = 48/158 (30%), Positives = 77/158 (48%), Gaps = 6/158 (3%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G++ +V L++ +++ G T L LAA V + IL+D G ++A
Sbjct: 1059 LTLACAGGHEELVSVLIARDA--KIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 127 -TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ TPL +A + G + +V AN + D TP+ LAA G+ II++L +
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Query: 186 KFKASIFERT--KDGSTLMHIASLNGHADCAMMLFKKG 221
A I RT K G + + +A++NGH +L G
Sbjct: 1177 A-GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG 1213
Score = 59.3 bits (137), Expect = 1e-07
Identities = 36/121 (29%), Positives = 53/121 (43%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL+ A G + R LL + DTAL +AA + +L+ GA
Sbjct: 1257 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGA 1316
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+D N G TPL +A+ G +V+ A+ ADN TP+ A GH +++
Sbjct: 1317 HIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQY 1376
Query: 183 L 183
L
Sbjct: 1377 L 1377
Score = 58.0 bits (134), Expect = 3e-07
Identities = 50/161 (31%), Positives = 75/161 (46%), Gaps = 4/161 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL+LA G+ V+ LL + + T +TAL LA + ++ +L+D A
Sbjct: 1190 GISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR-NTALTLACFQGRAEVVSLLLDRKA 1248
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPMHLAAENGHAAII 180
V+ G TPL AA+ G + + G NA + T + +AA+ GH
Sbjct: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1308
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
ELL + A I R K G+T + +AS GH D +L + G
Sbjct: 1309 ELLIHR-GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAG 1348
Score = 56.8 bits (131), Expect = 8e-07
Identities = 43/162 (26%), Positives = 75/162 (46%), Gaps = 3/162 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL+LA AG+ +V E+L + + + DT L LA ++ +L+
Sbjct: 1086 KKGFTPLILAATAGHVGVV-EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLAR 1144
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPMHLAAENGHAA 178
GA + N + TPL +AA+ G ++K G N+ +P+ LAA NGH
Sbjct: 1145 GANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVP 1204
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
++LL D + + +T + +A G A+ +L +
Sbjct: 1205 AVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDR 1246
Score = 55.2 bits (127), Expect = 2e-06
Identities = 45/168 (26%), Positives = 77/168 (45%), Gaps = 6/168 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G ++++ LL+A + + G + L LAA V ++L+D G+ ++
Sbjct: 1158 PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDIN 1217
Query: 126 ATNGAGQ-TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A + T L +A +G +V +AN TP+ AA G+A + +L
Sbjct: 1218 AQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1277
Query: 185 DK---FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
DK A ++D T + IA+ GH +L +G ++ + NK
Sbjct: 1278 DKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIHRGAHIDVRNK 1323
Score = 53.6 bits (123), Expect = 7e-06
Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 2/165 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL+ A AG+ + R LL + ++AL LA + +DM R L++
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNE-FKESALTLACYKGHLDMVRFLLEA 394
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA + T L A +G + + A + + +P+ LAA GH +
Sbjct: 395 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 454
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
LL ++ A++ E +G T + A+ GH + +L +G ++
Sbjct: 455 ALLIER-GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Score = 51.6 bits (118), Expect = 3e-05
Identities = 45/160 (28%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G+ + L+ + L+ G T L AAR +M +L+ GA ++
Sbjct: 441 PLTLAACGGHVELAALLI--ERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Query: 126 A-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A T +T L +A G + + ++A A I + TP+ A++ GH +++ L
Sbjct: 499 AQTEETQETALTLACCGGFSEVADFL--IKAGADI-ELGCSTPLMEASQEGHLELVKYLL 555
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
A++ T G T + A NGH D A +L + G L
Sbjct: 556 AS-GANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/162 (25%), Positives = 68/162 (41%), Gaps = 3/162 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGD-TALHLAARRRDVDMARILVD 119
+ G+ L LA AG + + LL+ + + GD T L A+ +D+ ++L+
Sbjct: 236 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK--GDITPLMAASSGGYLDIVKLLLL 293
Query: 120 YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
+ A V++ + G T L A A G +VK AN + TP+ AA GH +
Sbjct: 294 HDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEV 353
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+L D + + + +A GH D L + G
Sbjct: 354 ARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
Score = 45.6 bits (103), Expect = 0.002
Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 2/121 (1%)
Query: 110 DVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE-DRTPM 168
DV+ R L+D G V+ G++ L +A + G L + + AN N+ D TP+
Sbjct: 217 DVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPL 276
Query: 169 HLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
A+ G+ I++LL A + ++ G+T + A G D +L +G + N
Sbjct: 277 MAASSGGYLDIVKLLL-LHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 229 K 229
+
Sbjct: 336 E 336
Score = 44.8 bits (101), Expect = 0.003
Identities = 34/101 (33%), Positives = 47/101 (46%), Gaps = 5/101 (4%)
Query: 124 VDA-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+DA T T L +A A G E LV A D + TP+ LAA GH ++E+
Sbjct: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
Query: 183 LADKFK--ASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L DK + ERTKD T + +A G + +L +G
Sbjct: 1107 LLDKGGDIEAQSERTKD--TPLSLACSGGRQEVVDLLLARG 1145
Score = 44.4 bits (100), Expect = 0.004
Identities = 40/156 (25%), Positives = 63/156 (40%), Gaps = 7/156 (4%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G + L+ A +L +TP L A++ +++ + L+ GA V A
Sbjct: 509 LTLACCGGFSEVADFLIKAGADIELGCSTP-----LMEASQEGHLELVKYLLASGANVHA 563
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
T G T L A G + A+ RTP+ AA GH ++ L K
Sbjct: 564 TTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISK 623
Query: 187 FKASIFERTKDGS-TLMHIASLNGHADCAMMLFKKG 221
A++ T + T++ +A GH +L G
Sbjct: 624 -GANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
Score = 42.7 bits (96), Expect = 0.014
Identities = 44/155 (28%), Positives = 72/155 (46%), Gaps = 15/155 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY-TALHIAVESCKPAVVETLLGYGA 720
+G + AAR GH ++ LL +G +++ T + TAL +A V + L+ GA
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529
Query: 721 DVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
D+ + TPL A++ +G + LL SGA + T G T + A + G+
Sbjct: 530 DIEL----GCSTPLMEASQ--EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 583
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRS 814
+LL+ G D +++ G TPL A R+
Sbjct: 584 ADVLLQAGADLEHESE-------GGRTPLMKAARA 611
Score = 41.1 bits (92), Expect = 0.041
Identities = 31/128 (24%), Positives = 58/128 (45%), Gaps = 2/128 (1%)
Query: 99 DTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRAN-A 157
DTAL LA ++ +L+ A ++ + G TPL +AA G +V+ +
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 158 AIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
A ++ TP+ LA G +++LL + A+ R T + +A+ G+ + +L
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLAR-GANKEHRNVSDYTPLSLAASGGYVNIIKIL 1174
Query: 218 FKKGVYLH 225
G ++
Sbjct: 1175 LNAGAEIN 1182
Score = 39.9 bits (89), Expect = 0.096
Identities = 44/173 (25%), Positives = 71/173 (41%), Gaps = 9/173 (5%)
Query: 674 GHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG-GKQRET 732
G +++ LL + +V+ T L A V LL GADV+ R+T
Sbjct: 1235 GRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 1294
Query: 733 PLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLR 792
L IAA C L L+ GA + + G TP+ +A+ G+ + LL++ G D
Sbjct: 1295 ALTIAADKGHYKFCEL-LIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353
Query: 793 KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDE 845
I TPL A R +V++L++ V + +I + +
Sbjct: 1354 ADNRKI-------TPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITD 1399
Score = 37.9 bits (84), Expect = 0.39
Identities = 28/111 (25%), Positives = 49/111 (44%), Gaps = 1/111 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
L AE H+ + L A + G V LL +G +N + G + L A AG
Sbjct: 190 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 249
Query: 1358 HLNVVKLLCESGASPKSETNL-NCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
+ + ++L A+ + N + P+ A+S + D+++ LL + D S
Sbjct: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
>AF521882-1|AAO14943.1| 2542|Homo sapiens multiple ankyrin repeats
single KH domain protein isoform 1 protein.
Length = 2542
Score = 159 bits (385), Expect = 1e-37
Identities = 145/496 (29%), Positives = 223/496 (44%), Gaps = 33/496 (6%)
Query: 936 ACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNG 995
AC G + V LL V+ EG S L LA GY ++ LL A + + G
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 996 R-TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
T L A+ GY +VK L+ H+A ++ + T L A A G +++ K+LL GAN
Sbjct: 272 DITPLMAASSGGYLDIVKLLLL-HDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 330
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
I+ +E G P+ AA + EV ++ L + + + + +A +G + ++
Sbjct: 331 IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRF 390
Query: 1115 LMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
L++ G T L A GH +V R+L+ +GA + + + LAA
Sbjct: 391 LLE---AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447
Query: 1175 HGHTNV--LDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL---SHVPGTVKSEA 1229
GH + L + R N ++ + G TPL AA G E V LL +++ +
Sbjct: 448 GGHVELAALLIERGANLEEVNDE--GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ 505
Query: 1230 PTGVSL------------VPVLGAESGL---TPLHLAAYNGNENVVRLLLNS-AGVQADA 1273
T ++L + GA+ L TPL A+ G+ +V+ LL S A V A
Sbjct: 506 ETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATT 565
Query: 1274 ASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLL 1333
A+ G L AC GH + +LL A+L H ++ G+T L A+ GH V+ L+
Sbjct: 566 AT---GDTALTYACENGHTDVADVLLQAGADLEHESE-GGRTPLMKAARAGHLCTVQFLI 621
Query: 1334 GQGAEIN-ATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHN 1392
+GA +N AT N T + A GHL VV+LL GA P + AA H
Sbjct: 622 SKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 681
Query: 1393 DVLEYLLHKEHDTQSL 1408
+V+ YLL ++ S+
Sbjct: 682 NVVSYLLDYPNNVLSV 697
Score = 144 bits (348), Expect = 4e-33
Identities = 123/430 (28%), Positives = 207/430 (48%), Gaps = 33/430 (7%)
Query: 1054 NIDA-TDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVI 1112
+IDA T+ + A + E+V + + + + K G T +AA G V V+
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAK-IEHRDKKGFTPLILAATAGHVGVV 1104
Query: 1113 EELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA 1172
E L+ D+ G I A+++ TPL LA GG +VV +L+ GA+ N + T + LA
Sbjct: 1105 EILL--DKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162
Query: 1173 AEHGHTNVLDVMRSTNTLRISSK---KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEA 1229
A G+ N++ ++ + I+S+ KLG++PL +AA G V+ LL + + ++
Sbjct: 1163 ASGGYVNIIKILLNAGA-EINSRTGSKLGISPLMLAAMNGHVPAVKLLLD-MGSDINAQI 1220
Query: 1230 PTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLN-SAGVQADAASNENGYNPLHLACF 1288
T + T L LA + G VV LLL+ A V+ A + G PL A
Sbjct: 1221 ETNRN-----------TALTLACFQGRAEVVSLLLDRKANVEHRA---KTGLTPLMEAAS 1266
Query: 1289 GGHMSIVGLLLSRSAEL-LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGW 1347
GG+ + +LL + A++ T L IA+ GHY+ E+L+ +GA I+ +K G
Sbjct: 1267 GGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGN 1326
Query: 1348 TPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
TPL A+ GH +VV+LL ++GA + N P+ A + H V++YL+ + + S
Sbjct: 1327 TPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPS 1386
Query: 1408 LMDDKRFVYNLM---VCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIY---INLSTKEKER 1461
++ R++ + + K H +E V A K ++I ++L +E
Sbjct: 1387 DIECMRYIATITDKELLKKCHQ--CVETIVKAKDQQAAEANKNASILLKELDLEKSREES 1444
Query: 1462 AKDLIAAGKQ 1471
K +AA ++
Sbjct: 1445 RKQALAAKRE 1454
Score = 142 bits (344), Expect = 1e-32
Identities = 150/521 (28%), Positives = 236/521 (45%), Gaps = 41/521 (7%)
Query: 665 RSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHI 724
RS+ A G V + LL +G SV+ T + + L +A + + + LL A+V
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 266
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLL 784
RG K TPL A+ D L+LL A N + G T + A G + + +LL
Sbjct: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHD-ADVNSQSATGNTALTYACAGGFVDIVKVLL 325
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD 844
+G + + G TPL A + ++ R L+ DH G ++T +
Sbjct: 326 NEGANIEDHNE-------NGHTPLMEAASAGHVEVARVLL----DH-GAGINTHS----N 369
Query: 845 EDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNND 904
E SAL AC +V+ L+E GAD +T H C + G+ +
Sbjct: 370 EFKESALTLACY---------KGHLDMVRFLLEAGADQEHKTDEMHTALMEAC-MDGHVE 419
Query: 905 VMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRS 964
V ++ S A V+ + S PL +A GH++L L+ A ++ + EG +
Sbjct: 420 VARLLLD--SGAQVNMPADSFES----PLTLAACGGHVELAALLIERGANLEEVNDEGYT 473
Query: 965 ALHLAAEHGYLQVCDALLTNKAFINSKARNGR-TALHLAAMNGYAHLVKFLIRDHNAMID 1023
L AA G+ ++ LL A IN++ + TAL LA G++ + FLI+ A D
Sbjct: 474 PLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIK---AGAD 530
Query: 1024 VLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
+ L TPL A+ G +E+ K LL GAN+ AT G + A +N +++V + LQ
Sbjct: 531 I-ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589
Query: 1084 QHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGG 1143
+L + + G T AA G + ++ L+ + ++ ND T + LA GG
Sbjct: 590 AGADLEHES-EGGRTPLMKAARAGHLCTVQFLIS--KGANVNRATANNDHTVVSLACAGG 646
Query: 1144 HADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
H VV +L+ GA T + G T + AA+ GHTNV+ +
Sbjct: 647 HLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687
Score = 120 bits (289), Expect = 6e-26
Identities = 92/293 (31%), Positives = 145/293 (49%), Gaps = 9/293 (3%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
T L +AC GH +LV+ L+ A+++ D +G + L LAA G++ V + LL I +
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 991 KA-RNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL 1049
++ R T L LA G +V L+ A + + TPL LAA+ G + + K+LL
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLA-RGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
Query: 1050 ELGANIDAT--DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQG 1107
GA I++ +LG P+ AA N + V+L L ++ + NT +A QG
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
Query: 1108 SVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGA--SCTDENRAG 1165
+V+ L+ DR + R K TPL AA GG+A+V RVL+ GA + +
Sbjct: 1236 RAEVVSLLL--DRKANVEHRAK-TGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1292
Query: 1166 LTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
TA+ +AA+ GH +++ K G TPL +A+ G + V+ L+
Sbjct: 1293 DTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLV 1345
Score = 114 bits (274), Expect = 4e-24
Identities = 115/433 (26%), Positives = 188/433 (43%), Gaps = 36/433 (8%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A G V I+ LL +G +++ + +T L A + V LL +GA +
Sbjct: 305 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 364
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + +E+ L +A D LL++GA T++ T + A G++ L
Sbjct: 365 NTHSNEFKESALTLACYKGHLDMVRF-LLEAGADQEHKTDEMHTALMEACMDGHVEVARL 423
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL+ G + E+PL +A ++ LIE +G A ++
Sbjct: 424 LLDSGAQVNMPAD-------SFESPLTLAACGGHVELAALLIE-----RG-----ANLEE 466
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
V+++G + L A + EE+ V L+ GA+++ QT ETA G
Sbjct: 467 VNDEGYTPLMEAAREGHEEM---------VALLLAQGANINAQTEETQETALTLACCGGF 517
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
++V +I + AD+ + TPL+ A GH++LV LL + A V G
Sbjct: 518 SEVADFLIK--AGADIELGCS-------TPLMEASQEGHLELVKYLLASGANVHATTATG 568
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+AL A E+G+ V D LL A + ++ GRT L AA G+ V+FLI +
Sbjct: 569 DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVN 628
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
T + LA A G + V +LLL GA+ + G + AA+ ++ VV L
Sbjct: 629 RATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
Query: 1083 QQHPNLVMATTKD 1095
N++ T D
Sbjct: 689 DYPNNVLSVPTTD 701
Score = 114 bits (274), Expect = 4e-24
Identities = 98/346 (28%), Positives = 162/346 (46%), Gaps = 15/346 (4%)
Query: 881 DVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRG 940
D+ T NH+TA G+ ++++ +IA + ++ G+TPL++A G
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIAR------DAKIEHRDKKGFTPLILAATAG 1099
Query: 941 HMQLVNTLLTNHARVDVFDVEGR-SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTAL 999
H+ +V LL ++ + + L LA G +V D LL A + + T L
Sbjct: 1100 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPL 1159
Query: 1000 HLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQ--TPLHLAAASGQIEVCKLLLELGANIDA 1057
LAA GY +++K L+ + A I+ T K +PL LAA +G + KLLL++G++I+A
Sbjct: 1160 SLAASGGYVNIIKILL-NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINA 1218
Query: 1058 TDELGQK-PIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
E + + A +EVV L L + N V K G T AA G +V L+
Sbjct: 1219 QIETNRNTALTLACFQGRAEVVSLLLDRKAN-VEHRAKTGLTPLMEAASGGYAEVGRVLL 1277
Query: 1117 KFDRTGVISARN-KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEH 1175
D+ ++A + T L +AA+ GH +L+ GA N+ G T + LA+
Sbjct: 1278 --DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNG 1335
Query: 1176 GHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
GH +V+ ++ ++ +TPL A G + V+ L+ V
Sbjct: 1336 GHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEV 1381
Score = 90.6 bits (215), Expect = 5e-17
Identities = 66/226 (29%), Positives = 109/226 (48%), Gaps = 5/226 (2%)
Query: 1211 AETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQ 1270
A+T+ + L + V + PTG + LTP + N + V
Sbjct: 989 AQTLTDTLDDLIAAVSTRVPTGSNSSSQ--TTECLTPESCSQTTSNVASQSMPPVYPSVD 1046
Query: 1271 ADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVE 1330
DA + N L LAC GGH +V +L++R A++ H D+ G T L +A+T GH +VE
Sbjct: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEH-RDKKGFTPLILAATAGHVGVVE 1105
Query: 1331 VLLGQGAEINA-TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASE 1389
+LL +G +I A +++ TPL A G VV LL GA+ + + P+ AAS
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165
Query: 1390 NHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVL 1435
+ ++++ LL+ + S K + LM+ + N ++P + +L
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN-GHVPAVKLLL 1210
Score = 87.0 bits (206), Expect = 6e-16
Identities = 84/323 (26%), Positives = 151/323 (46%), Gaps = 32/323 (9%)
Query: 764 GMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHL 823
G TP+ +AA G++ + +LL+ GGD +++ T +TPL +AC ++V L
Sbjct: 1088 GFTPLILAATAGHVGVVEILLDKGGDIEAQSER------TKDTPLSLACSGGRQEVVDLL 1141
Query: 824 IEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVS 883
+ + + +VS D A++ Y ++K L+ GA+++
Sbjct: 1142 LARGANKEHRNVS----DYTPLSLAASGGYV---------------NIIKILLNAGAEIN 1182
Query: 884 LQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQ 943
+T + A + +++ + + D++ + + T L +AC +G +
Sbjct: 1183 SRTGSKLGISPLMLAAMNGHVPAVKLLLDMGS-DINAQIETNRN---TALTLACFQGRAE 1238
Query: 944 LVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKA--RNGRTALHL 1001
+V+ LL A V+ G + L AA GY +V LL A +N+ + TAL +
Sbjct: 1239 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1298
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
AA G+ + LI A IDV K TPL LA+ G +V +LL++ GA++DA D
Sbjct: 1299 AADKGHYKFCELLIH-RGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQ 1084
P+ +A + + +VVQ +++
Sbjct: 1358 KITPLMSAFRKGHVKVVQYLVKE 1380
Score = 80.2 bits (189), Expect = 7e-14
Identities = 55/154 (35%), Positives = 80/154 (51%), Gaps = 6/154 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL+ A + G+ +V+ LL++ + ATT GDTAL A D+A +L+ GA ++
Sbjct: 538 PLMEASQEGHLELVKYLLAS--GANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 595
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
+ G+TPL AA G V++ G N A A+N D T + LA GH A++ELL
Sbjct: 596 HESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN-DHTVVSLACAGGHLAVVELL 654
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
A R KDGST++ A+ GH + L
Sbjct: 655 L-AHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687
Score = 73.7 bits (173), Expect = 6e-12
Identities = 81/346 (23%), Positives = 147/346 (42%), Gaps = 29/346 (8%)
Query: 674 GHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETP 733
GH +++ L+ + ++ +T L +A + VVE LL G D+ + + ++TP
Sbjct: 1066 GHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTP 1125
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L +A + +LL GA TP+ +AA G + + +LL G + +
Sbjct: 1126 LSLACS-GGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR 1184
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHY 853
T + G +PL +A + V+ L++ D + ++ + +AL
Sbjct: 1185 TGSKL-----GISPLMLAAMNGHVPAVKLLLDMGSDINAQ---------IETNRNTALTL 1230
Query: 854 ACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHI 913
AC + EV DR K +E+ A L E A A G V+ + A +
Sbjct: 1231 ACFQGRAEVVSLLLDR---KANVEHRAKTGLTPLM--EAASGGYAEVGR--VLLDKGADV 1283
Query: 914 STADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHG 973
+ V + + T L IA +GH + L+ A +DV + +G + L LA+ G
Sbjct: 1284 NAPPVPSSRD-------TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGG 1336
Query: 974 YLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
+ V L+ A +++ T L A G+ +V++L+++ N
Sbjct: 1337 HFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVN 1382
Score = 70.5 bits (165), Expect = 6e-11
Identities = 98/381 (25%), Positives = 164/381 (43%), Gaps = 44/381 (11%)
Query: 611 VPTELLPIIWKPISKDSFYTLNIDTAMELK-SGFFEDRMIFWDTFFEKYKHFD--GARSI 667
V ++ +P ++ + D+ N DTA+ L +G E+ + K +H D G +
Sbjct: 1033 VASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPL 1092
Query: 668 HTAARYGHVGIINTLLQKGESVDV-TTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
AA GHVG++ LL KG ++ + T L +A + VV+ LL GA+ R
Sbjct: 1093 ILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRN 1152
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNLATLVLLL 784
TPL +AA +LL +GA N T G++P+ +AA G++ + LLL
Sbjct: 1153 VSD-YTPLSLAAS-GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 1210
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVK--DHKGESVSTAFIDA 842
+ G D + + T L +AC ++V L++ +H+ ++ T ++A
Sbjct: 1211 DMGSDINAQIE------TNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEA 1264
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSL-QTRHNHETAFHYCAIAG 901
G A +V + L++ GADV+ + +TA A G
Sbjct: 1265 A--SGGYA-------------------EVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1303
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ +I + DV +N G TPL +A + GH +V L+ A VD D
Sbjct: 1304 HYKFCELLIHRGAHIDV------RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357
Query: 962 GRSALHLAAEHGYLQVCDALL 982
+ L A G+++V L+
Sbjct: 1358 KITPLMSAFRKGHVKVVQYLV 1378
Score = 64.1 bits (149), Expect = 5e-09
Identities = 46/172 (26%), Positives = 82/172 (47%), Gaps = 3/172 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G + L+A +G + +LL A+ + + + G+TAL A VD+ ++L++ G
Sbjct: 270 KGDITPLMAASSGGYLDIVKLLLLHDAD-VNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAAENGHAAII 180
A ++ N G TPL AA+ G + + A NE + + + LA GH ++
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFE 232
L + A +T + T + A ++GH + A +L G ++MP FE
Sbjct: 389 RFLLEA-GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
Score = 62.1 bits (144), Expect = 2e-08
Identities = 51/161 (31%), Positives = 79/161 (49%), Gaps = 4/161 (2%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G+ MVR LL A ++ K T TAL A V++AR+L+D GA V+
Sbjct: 376 LTLACYKGHLDMVRFLLEAGADQEHK--TDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ ++PL +AA G L AN ++E TP+ AA GH ++ LL +
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Query: 187 FKASIFERTKD-GSTLMHIASLNGHADCAMMLFKKGVYLHM 226
A+I +T++ T + +A G ++ A L K G + +
Sbjct: 494 -GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL 533
Score = 62.1 bits (144), Expect = 2e-08
Identities = 48/158 (30%), Positives = 77/158 (48%), Gaps = 6/158 (3%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G++ +V L++ +++ G T L LAA V + IL+D G ++A
Sbjct: 1059 LTLACAGGHEELVSVLIARDA--KIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 127 -TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ TPL +A + G + +V AN + D TP+ LAA G+ II++L +
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Query: 186 KFKASIFERT--KDGSTLMHIASLNGHADCAMMLFKKG 221
A I RT K G + + +A++NGH +L G
Sbjct: 1177 A-GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG 1213
Score = 59.3 bits (137), Expect = 1e-07
Identities = 36/121 (29%), Positives = 53/121 (43%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL+ A G + R LL + DTAL +AA + +L+ GA
Sbjct: 1257 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGA 1316
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+D N G TPL +A+ G +V+ A+ ADN TP+ A GH +++
Sbjct: 1317 HIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQY 1376
Query: 183 L 183
L
Sbjct: 1377 L 1377
Score = 58.0 bits (134), Expect = 3e-07
Identities = 50/161 (31%), Positives = 75/161 (46%), Gaps = 4/161 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL+LA G+ V+ LL + + T +TAL LA + ++ +L+D A
Sbjct: 1190 GISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR-NTALTLACFQGRAEVVSLLLDRKA 1248
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPMHLAAENGHAAII 180
V+ G TPL AA+ G + + G NA + T + +AA+ GH
Sbjct: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1308
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
ELL + A I R K G+T + +AS GH D +L + G
Sbjct: 1309 ELLIHR-GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAG 1348
Score = 56.8 bits (131), Expect = 8e-07
Identities = 43/162 (26%), Positives = 75/162 (46%), Gaps = 3/162 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL+LA AG+ +V E+L + + + DT L LA ++ +L+
Sbjct: 1086 KKGFTPLILAATAGHVGVV-EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLAR 1144
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPMHLAAENGHAA 178
GA + N + TPL +AA+ G ++K G N+ +P+ LAA NGH
Sbjct: 1145 GANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVP 1204
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
++LL D + + +T + +A G A+ +L +
Sbjct: 1205 AVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDR 1246
Score = 55.2 bits (127), Expect = 2e-06
Identities = 45/168 (26%), Positives = 77/168 (45%), Gaps = 6/168 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G ++++ LL+A + + G + L LAA V ++L+D G+ ++
Sbjct: 1158 PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDIN 1217
Query: 126 ATNGAGQ-TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A + T L +A +G +V +AN TP+ AA G+A + +L
Sbjct: 1218 AQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1277
Query: 185 DK---FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
DK A ++D T + IA+ GH +L +G ++ + NK
Sbjct: 1278 DKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIHRGAHIDVRNK 1323
Score = 53.6 bits (123), Expect = 7e-06
Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 2/165 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL+ A AG+ + R LL + ++AL LA + +DM R L++
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNE-FKESALTLACYKGHLDMVRFLLEA 394
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA + T L A +G + + A + + +P+ LAA GH +
Sbjct: 395 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 454
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
LL ++ A++ E +G T + A+ GH + +L +G ++
Sbjct: 455 ALLIER-GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Score = 51.6 bits (118), Expect = 3e-05
Identities = 45/160 (28%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G+ + L+ + L+ G T L AAR +M +L+ GA ++
Sbjct: 441 PLTLAACGGHVELAALLI--ERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Query: 126 A-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A T +T L +A G + + ++A A I + TP+ A++ GH +++ L
Sbjct: 499 AQTEETQETALTLACCGGFSEVADFL--IKAGADI-ELGCSTPLMEASQEGHLELVKYLL 555
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
A++ T G T + A NGH D A +L + G L
Sbjct: 556 AS-GANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/162 (25%), Positives = 68/162 (41%), Gaps = 3/162 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGD-TALHLAARRRDVDMARILVD 119
+ G+ L LA AG + + LL+ + + GD T L A+ +D+ ++L+
Sbjct: 236 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK--GDITPLMAASSGGYLDIVKLLLL 293
Query: 120 YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
+ A V++ + G T L A A G +VK AN + TP+ AA GH +
Sbjct: 294 HDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEV 353
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+L D + + + +A GH D L + G
Sbjct: 354 ARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
Score = 45.6 bits (103), Expect = 0.002
Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 2/121 (1%)
Query: 110 DVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE-DRTPM 168
DV+ R L+D G V+ G++ L +A + G L + + AN N+ D TP+
Sbjct: 217 DVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPL 276
Query: 169 HLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
A+ G+ I++LL A + ++ G+T + A G D +L +G + N
Sbjct: 277 MAASSGGYLDIVKLLL-LHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 229 K 229
+
Sbjct: 336 E 336
Score = 44.8 bits (101), Expect = 0.003
Identities = 34/101 (33%), Positives = 47/101 (46%), Gaps = 5/101 (4%)
Query: 124 VDA-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+DA T T L +A A G E LV A D + TP+ LAA GH ++E+
Sbjct: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
Query: 183 LADKFK--ASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L DK + ERTKD T + +A G + +L +G
Sbjct: 1107 LLDKGGDIEAQSERTKD--TPLSLACSGGRQEVVDLLLARG 1145
Score = 44.4 bits (100), Expect = 0.004
Identities = 40/156 (25%), Positives = 63/156 (40%), Gaps = 7/156 (4%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G + L+ A +L +TP L A++ +++ + L+ GA V A
Sbjct: 509 LTLACCGGFSEVADFLIKAGADIELGCSTP-----LMEASQEGHLELVKYLLASGANVHA 563
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
T G T L A G + A+ RTP+ AA GH ++ L K
Sbjct: 564 TTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISK 623
Query: 187 FKASIFERTKDGS-TLMHIASLNGHADCAMMLFKKG 221
A++ T + T++ +A GH +L G
Sbjct: 624 -GANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
Score = 42.7 bits (96), Expect = 0.014
Identities = 44/155 (28%), Positives = 72/155 (46%), Gaps = 15/155 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY-TALHIAVESCKPAVVETLLGYGA 720
+G + AAR GH ++ LL +G +++ T + TAL +A V + L+ GA
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529
Query: 721 DVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
D+ + TPL A++ +G + LL SGA + T G T + A + G+
Sbjct: 530 DIEL----GCSTPLMEASQ--EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 583
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRS 814
+LL+ G D +++ G TPL A R+
Sbjct: 584 ADVLLQAGADLEHESE-------GGRTPLMKAARA 611
Score = 41.1 bits (92), Expect = 0.041
Identities = 31/128 (24%), Positives = 58/128 (45%), Gaps = 2/128 (1%)
Query: 99 DTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRAN-A 157
DTAL LA ++ +L+ A ++ + G TPL +AA G +V+ +
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 158 AIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
A ++ TP+ LA G +++LL + A+ R T + +A+ G+ + +L
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLAR-GANKEHRNVSDYTPLSLAASGGYVNIIKIL 1174
Query: 218 FKKGVYLH 225
G ++
Sbjct: 1175 LNAGAEIN 1182
Score = 39.9 bits (89), Expect = 0.096
Identities = 44/173 (25%), Positives = 71/173 (41%), Gaps = 9/173 (5%)
Query: 674 GHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG-GKQRET 732
G +++ LL + +V+ T L A V LL GADV+ R+T
Sbjct: 1235 GRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 1294
Query: 733 PLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLR 792
L IAA C L L+ GA + + G TP+ +A+ G+ + LL++ G D
Sbjct: 1295 ALTIAADKGHYKFCEL-LIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353
Query: 793 KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDE 845
I TPL A R +V++L++ V + +I + +
Sbjct: 1354 ADNRKI-------TPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITD 1399
Score = 37.9 bits (84), Expect = 0.39
Identities = 28/111 (25%), Positives = 49/111 (44%), Gaps = 1/111 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
L AE H+ + L A + G V LL +G +N + G + L A AG
Sbjct: 190 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 249
Query: 1358 HLNVVKLLCESGASPKSETNL-NCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
+ + ++L A+ + N + P+ A+S + D+++ LL + D S
Sbjct: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
>AC017035-2|AAY15060.1| 394|Homo sapiens unknown protein.
Length = 394
Score = 159 bits (385), Expect = 1e-37
Identities = 125/378 (33%), Positives = 181/378 (47%), Gaps = 25/378 (6%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
+PL +A + GH Q + LL + +D+ D +GR+AL LAA G+ + +AL+ A I
Sbjct: 19 SPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINQGASIFV 78
Query: 991 KAR-NGRTALHLAAMNGYAHLVKFL--IRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKL 1047
K RT LH + +NG+ ++ L I D+ +DV K QTPL LA A G I+ L
Sbjct: 79 KDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSL 138
Query: 1048 LLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQG 1107
LLE AN+D D LG +H + E VQ+ L+Q +++ ++ G T H AA +G
Sbjct: 139 LLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSR-GRTPLHYAAARG 197
Query: 1108 SVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAG-L 1166
+ EL++ + TPL A G+ + + VL+ C +
Sbjct: 198 HATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE--QKCFRKFIGNPF 255
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKK--LGLTPLHIAAYYGQAETVRELLSHVPGT 1224
T +H A + H N ++ I S + G TPLH AA+ E ++ LL H
Sbjct: 256 TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLHAAAFADHVECLQLLLRH---- 311
Query: 1225 VKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYN-PL 1283
AP V+ V SG T L +AA NG V +L+NSA QAD + N PL
Sbjct: 312 ---SAP--VNAVD----NSGKTALMMAAENGQAGAVDILVNSA--QADLTVKDKDLNTPL 360
Query: 1284 HLACFGGHMSIVGLLLSR 1301
HLAC GH L+L +
Sbjct: 361 HLACSKGHEKCALLILDK 378
Score = 153 bits (370), Expect = 9e-36
Identities = 112/387 (28%), Positives = 176/387 (45%), Gaps = 20/387 (5%)
Query: 1030 QTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
++PLHLAA +G + ++LL+ ++D DE G+ + AA ++E V+ + Q ++
Sbjct: 18 KSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINQGASIF 77
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKF-DRTGVISARNKLNDSTPLQLAAEGGHADVV 1148
+ T H + I G + L++ D + ++ TPL LA GH D V
Sbjct: 78 VKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDA-KGQTPLMLAVAYGHIDAV 136
Query: 1149 RVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYY 1208
+L+ A+ + G TA+H GH + ++ + G TPLH AA
Sbjct: 137 SLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAAR 196
Query: 1209 GQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAG 1268
G A + ELL SE G TPLH A YNGNEN + +LL
Sbjct: 197 GHATWLSELLQ----MALSEEDC------CFKDNQGYTPLHWACYNGNENCIEVLLEQKC 246
Query: 1269 VQADAASNENGYNPLHLACFGGHMSIVGLLLSR-SAELLHSTDRHGKTGLHIASTHGHYQ 1327
+ N + PLH A H + LLL + ++ D G+T LH A+ H +
Sbjct: 247 FRKFIG---NPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLHAAAFADHVE 303
Query: 1328 MVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKS--ETNLNCAPIWF 1385
+++LL A +NA D +G T L AA+ G V +L S + + + +LN P+
Sbjct: 304 CLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLN-TPLHL 362
Query: 1386 AASENHNDVLEYLLHKEHDTQSLMDDK 1412
A S+ H +L K D +SL+++K
Sbjct: 363 ACSKGHEKCALLILDKIQD-ESLINEK 388
Score = 132 bits (320), Expect = 1e-29
Identities = 109/393 (27%), Positives = 177/393 (45%), Gaps = 28/393 (7%)
Query: 983 TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQI 1042
TN F S + ++ LHLAA NG+ ++ L++ +D+ K +T L LAA G
Sbjct: 5 TNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQS-LVDLDIRDEKGRTALDLAAFKGHT 63
Query: 1043 EVCKLLLELGANIDATDELGQK-PIHAAAQNNYSEVVQLFLQ--QHPNLVMATTKDGNTC 1099
E + L+ GA+I D + ++ P+HA+ N ++ ++L L+ +P V G T
Sbjct: 64 ECVEALINQGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 123
Query: 1100 AHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
+A G + + L+ ++ + + L T L GH + V++L+ S
Sbjct: 124 LMLAVAYGHIDAVSLLL--EKEANVDTVDILG-CTALHRGIMTGHEECVQMLLEQEVSIL 180
Query: 1160 DENRAGLTAVHLAAEHGH----TNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
++ G T +H AA GH + +L + S + G TPLH A Y G +
Sbjct: 181 CKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQ-GYTPLHWACYNGNENCIE 239
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS 1275
LL +G + TPLH A N + N LLL + +
Sbjct: 240 VLLEQ------------KCFRKFIG--NPFTPLHCAIINDHGNCASLLLGAIDSSIVSCR 285
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQ 1335
++ G PLH A F H+ + LLL SA +++ D GKT L +A+ +G V++L+
Sbjct: 286 DDKGRTPLHAAAFADHVECLQLLLRHSAP-VNAVDNSGKTALMMAAENGQAGAVDILVNS 344
Query: 1336 G-AEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
A++ DK+ TPLH A GH L+ +
Sbjct: 345 AQADLTVKDKDLNTPLHLACSKGHEKCALLILD 377
Score = 125 bits (301), Expect = 2e-27
Identities = 107/380 (28%), Positives = 175/380 (46%), Gaps = 30/380 (7%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+S LHLAA +G+ Q + LL + ++ + GRTAL LAA G+ V+ LI ++
Sbjct: 18 KSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINQGASIF 77
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGAN---IDATDELGQKPIHAAAQNNYSEVVQ 1079
+ K+TPLH + +G +LLLE+ N +D D GQ P+ A + + V
Sbjct: 78 VKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVS 137
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLA 1139
L L++ N V G T H + G + ++ L++ ++ ++ TPL A
Sbjct: 138 LLLEKEAN-VDTVDILGCTALHRGIMTGHEECVQMLLE-QEVSILCKDSR--GRTPLHYA 193
Query: 1140 AEGGHADVVRVLVRAGAS---CTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
A GHA + L++ S C ++ G T +H A +G+ N ++V+ R K
Sbjct: 194 AARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFR---KF 250
Query: 1197 LG--LTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYN 1254
+G TPLH A LL + ++ S + G TPLH AA+
Sbjct: 251 IGNPFTPLHCAIINDHGNCASLLLGAIDSSIVS-----------CRDDKGRTPLHAAAFA 299
Query: 1255 GNENVVRLLL-NSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHG 1313
+ ++LLL +SA V A + +G L +A G V +L++ + L D+
Sbjct: 300 DHVECLQLLLRHSAPVN---AVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDL 356
Query: 1314 KTGLHIASTHGHYQMVEVLL 1333
T LH+A + GH + ++L
Sbjct: 357 NTPLHLACSKGHEKCALLIL 376
Score = 109 bits (262), Expect = 1e-22
Identities = 91/312 (29%), Positives = 145/312 (46%), Gaps = 11/312 (3%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
+ V+ LI GA + ++ T H I G+ + ++ I AD A++ +++ G
Sbjct: 64 ECVEALINQGASIFVKDNVTKRTPLHASVINGHT-LCLRLLLEI--ADNPEAVDVKDAKG 120
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
TPL++A GH+ V+ LL A VD D+ G +ALH G+ + LL + I
Sbjct: 121 QTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSIL 180
Query: 990 SKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQ--TPLHLAAASGQIEVCKL 1047
K GRT LH AA G+A + L++ + D Q TPLH A +G ++
Sbjct: 181 CKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEV 240
Query: 1048 LLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKD-GNTCAHIAAIQ 1106
LLE P+H A N++ L L + +++ D G T H AA
Sbjct: 241 LLEQKCFRKFIGN-PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLHAAAFA 299
Query: 1107 GSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR-AGASCTDENRAG 1165
V+ ++ L++ + ++A + + T L +AAE G A V +LV A A T +++
Sbjct: 300 DHVECLQLLLR--HSAPVNAVDN-SGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDL 356
Query: 1166 LTAVHLAAEHGH 1177
T +HLA GH
Sbjct: 357 NTPLHLACSKGH 368
Score = 96.7 bits (230), Expect = 8e-19
Identities = 104/388 (26%), Positives = 167/388 (43%), Gaps = 38/388 (9%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA GH + LLQ +D+ TAL +A VE L+ GA + ++
Sbjct: 21 LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINQGASIFVKD 80
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKA-TED--GMTPVHVAAKFGNLATLVLL 783
+ TPLH A+ I C +LL+ P +D G TP+ +A +G++ + LL
Sbjct: 81 NVTKRTPLH-ASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLL 139
Query: 784 LEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAV 843
LE ++ V D++ G T L + + V+ L+E + VS I
Sbjct: 140 LE------KEANVDTVDIL-GCTALHRGIMTGHEECVQMLLE-------QEVS---ILCK 182
Query: 844 DEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN 903
D G + LHYA T ++++ + D + + T H+ GN
Sbjct: 183 DSRGRTPLHYAAARGH-----ATWLSELLQMALSE-EDCCFKDNQGY-TPLHWACYNGNE 235
Query: 904 DVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLL--TNHARVDVFDVE 961
+ + ++ + + +TPL A H + LL + + V D +
Sbjct: 236 NCIEVLLE-------QKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDK 288
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAM 1021
GR+ LH AA +++ LL + A +N+ +G+TAL +AA NG A V L+ A
Sbjct: 289 GRTPLHAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQAD 348
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLL 1049
+ V TPLHLA + G E C LL+
Sbjct: 349 LTVKDKDLNTPLHLACSKGH-EKCALLI 375
Score = 85.0 bits (201), Expect = 3e-15
Identities = 105/391 (26%), Positives = 168/391 (42%), Gaps = 39/391 (9%)
Query: 700 LHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPN- 758
LH+A + +E LL D+ IR K R T L +AA +C L+ GA
Sbjct: 21 LHLAAYNGHHQALEVLLQSLVDLDIRDEKGR-TALDLAA-FKGHTECVEALINQGASIFV 78
Query: 759 KATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPD 818
K TP+H + G+ L LLLE +P V + D G+TPL +A D
Sbjct: 79 KDNVTKRTPLHASVINGHTLCLRLLLEIADNP---EAVDVKD-AKGQTPLMLAVAYGHID 134
Query: 819 IVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIEN 878
V L+E A +D VD G +ALH I T + V+ L+E
Sbjct: 135 AVSLLLE----------KEANVDTVDILGCTALHRG---------IMTGHEECVQMLLEQ 175
Query: 879 GADVSLQTRHNH-ETAFHYCAIAGNNDVMTEMI-AHISTADVSRALNRQNSIGWTPLLIA 936
+VS+ + + T HY A G+ ++E++ +S D N+ G+TPL A
Sbjct: 176 --EVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQ----GYTPLHWA 229
Query: 937 CHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALL--TNKAFINSKARN 994
C+ G+ + LL F + LH A + + LL + + ++ +
Sbjct: 230 CYNGNENCIEVLLEQKC-FRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDK 288
Query: 995 GRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELG-A 1053
GRT LH AA + ++ L+R H+A ++ + +T L +AA +GQ +L+ A
Sbjct: 289 GRTPLHAAAFADHVECLQLLLR-HSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQA 347
Query: 1054 NIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
++ D+ P+H A + + L L +
Sbjct: 348 DLTVKDKDLNTPLHLACSKGHEKCALLILDK 378
Score = 68.1 bits (159), Expect = 3e-10
Identities = 44/161 (27%), Positives = 75/161 (46%), Gaps = 5/161 (3%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY- 120
+G PL A GN++ + LL + + T LH A + A +L+
Sbjct: 221 QGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNP---FTPLHCAIINDHGNCASLLLGAI 277
Query: 121 -GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
++V + G+TPLH AA ++ A DN +T + +AAENG A
Sbjct: 278 DSSIVSCRDDKGRTPLHAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGA 337
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+++L + +A + + KD +T +H+A GH CA+++ K
Sbjct: 338 VDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDK 378
Score = 62.9 bits (146), Expect = 1e-08
Identities = 48/163 (29%), Positives = 74/163 (45%), Gaps = 7/163 (4%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
K PL LA G+ + LL Q+ L G TAL LAA + + L++ GA
Sbjct: 18 KSPLHLAAYNGHHQALEVLL--QSLVDLDIRDEKGRTALDLAAFKGHTECVEALINQGAS 75
Query: 124 VDAT-NGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED---RTPMHLAAENGHAAI 179
+ N +TPLH + G ++ + N D +D +TP+ LA GH
Sbjct: 76 IFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDA 135
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGV 222
+ LL +K +A++ G T +H + GH +C ML ++ V
Sbjct: 136 VSLLLEK-EANVDTVDILGCTALHRGIMTGHEECVQMLLEQEV 177
Score = 62.5 bits (145), Expect = 2e-08
Identities = 50/169 (29%), Positives = 75/169 (44%), Gaps = 5/169 (2%)
Query: 55 IRDLVFQRGKVPLLLAVEAGNQSMVRELLS-AQTAEQLKATTPAGDTALHLAARRRDVDM 113
++D V +R PL +V G+ +R LL A E + G T L LA +D
Sbjct: 78 VKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDA 135
Query: 114 ARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAE 173
+L++ A VD + G T LH G E V+ + D+ RTP+H AA
Sbjct: 136 VSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAA 195
Query: 174 NGHAA-IIELLADKF-KASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
GHA + ELL + + G T +H A NG+ +C +L ++
Sbjct: 196 RGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ 244
Score = 56.0 bits (129), Expect = 1e-06
Identities = 36/124 (29%), Positives = 58/124 (46%), Gaps = 1/124 (0%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL A+ + + LL A + + G T LH AA V+ ++L+ + A V+
Sbjct: 257 PLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLHAAAFADHVECLQLLLRHSAPVN 316
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYG-VRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A + +G+T L +AA G V +A+ + D + TP+HLA GH L+
Sbjct: 317 AVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 376
Query: 185 DKFK 188
DK +
Sbjct: 377 DKIQ 380
Score = 51.6 bits (118), Expect = 3e-05
Identities = 43/149 (28%), Positives = 71/149 (47%), Gaps = 4/149 (2%)
Query: 1298 LLSRSAELLHSTDRHG-KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKA 1356
LL R+ +D K+ LH+A+ +GH+Q +EVLL +++ D+ G T L AA
Sbjct: 1 LLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFK 60
Query: 1357 GHLNVVKLLCESGASPKSETNL-NCAPIWFAASENHNDVLEYLLHKEHDTQSL-MDDKRF 1414
GH V+ L GAS + N+ P+ + H L LL + +++ + D +
Sbjct: 61 GHTECVEALINQGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKG 120
Query: 1415 VYNLMVCSKNHNNIPIEEFVLVSPAPVDT 1443
LM+ + + +I +L A VDT
Sbjct: 121 QTPLML-AVAYGHIDAVSLLLEKEANVDT 148
Score = 51.6 bits (118), Expect = 3e-05
Identities = 30/96 (31%), Positives = 50/96 (52%), Gaps = 2/96 (2%)
Query: 125 DATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
++ +GA ++PLH+AA G ++ + I D + RT + LAA GH +E L
Sbjct: 11 ESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALI 70
Query: 185 DKFKASIFERTK-DGSTLMHIASLNGHADCAMMLFK 219
++ ASIF + T +H + +NGH C +L +
Sbjct: 71 NQ-GASIFVKDNVTKRTPLHASVINGHTLCLRLLLE 105
Score = 51.2 bits (117), Expect = 4e-05
Identities = 39/128 (30%), Positives = 59/128 (46%), Gaps = 5/128 (3%)
Query: 97 AGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRAN 156
A + LHLAA +L+ +D + G+T L +AA +G V+ A+
Sbjct: 16 ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINQGAS 75
Query: 157 AAIADN-EDRTPMHLAAENGHAAIIELL---ADKFKASIFERTKDGSTLMHIASLNGHAD 212
+ DN RTP+H + NGH + LL AD +A + K G T + +A GH D
Sbjct: 76 IFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAK-GQTPLMLAVAYGHID 134
Query: 213 CAMMLFKK 220
+L +K
Sbjct: 135 AVSLLLEK 142
Score = 46.8 bits (106), Expect = 8e-04
Identities = 37/129 (28%), Positives = 58/129 (44%), Gaps = 3/129 (2%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K G + A YGH+ ++ LL+K +VD TALH + + V+ LL
Sbjct: 116 KDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQ 175
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGN 776
+ + + R TPLH AA + +L + + + +D G TP+H A GN
Sbjct: 176 EVSILCKDSRGR-TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGN 234
Query: 777 LATLVLLLE 785
+ +LLE
Sbjct: 235 ENCIEVLLE 243
Score = 46.8 bits (106), Expect = 8e-04
Identities = 30/90 (33%), Positives = 46/90 (51%), Gaps = 3/90 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYG-AD 721
G +H AA HV + LL+ V+ N TAL +A E+ + V+ L+ AD
Sbjct: 289 GRTPLHAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQAD 348
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLL 751
+ ++ K TPLH+A +KCAL++L
Sbjct: 349 LTVK-DKDLNTPLHLACS-KGHEKCALLIL 376
Score = 46.0 bits (104), Expect = 0.001
Identities = 65/229 (28%), Positives = 93/229 (40%), Gaps = 25/229 (10%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVD---VTTNDNYTALHIAVESCKPAVVETLLGYG 719
G +H AA GH ++ LLQ S + N YT LH A + +E LL
Sbjct: 186 GRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQK 245
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNL 777
G TPLH A I D CA +LL + + D G TP+H AA ++
Sbjct: 246 CFRKFIGNPF--TPLHCAI-INDHGNCASLLLGAIDSSIVSCRDDKGRTPLHAAAFADHV 302
Query: 778 ATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVST 837
L LLL P+ +G+T L MA + V L+ + +
Sbjct: 303 ECLQLLLRHSA-PVNAVD------NSGKTALMMAAENGQAGAVDILV---------NSAQ 346
Query: 838 AFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQT 886
A + D+D + LH AC E+ + D+ + LI N + +LQT
Sbjct: 347 ADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLI-NEKNNALQT 394
Score = 43.2 bits (97), Expect = 0.010
Identities = 21/71 (29%), Positives = 37/71 (52%), Gaps = 4/71 (5%)
Query: 154 RANAAIADNED---RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
R N+ +++ ++P+HLAA NGH +E+L + R + G T + +A+ GH
Sbjct: 4 RTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSL-VDLDIRDEKGRTALDLAAFKGH 62
Query: 211 ADCAMMLFKKG 221
+C L +G
Sbjct: 63 TECVEALINQG 73
>AF039217-1|AAD02131.2| 1013|Homo sapiens inv candidate homolog
protein.
Length = 1013
Score = 157 bits (380), Expect = 5e-37
Identities = 132/465 (28%), Positives = 212/465 (45%), Gaps = 23/465 (4%)
Query: 942 MQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
+ + LL A V+ D R+ALHLAA+ G + LLT +A K T LHL
Sbjct: 9 LDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL 68
Query: 1002 AAMNGYAHLVKFLIRDHN-AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDE 1060
+ + L++ +D KQT LH +A E KLL++ +NI D
Sbjct: 69 TTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV 128
Query: 1061 LGQKPIHAAAQN---NYSEVVQLFLQQHPNLVMATTKD--GNTCAHIAAIQGSVKVIEEL 1115
G+ P+H AA + + V+ L P + +D G T H A G+V V++ L
Sbjct: 129 EGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVL 188
Query: 1116 MKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT-DENRAGLTAVHLAAE 1174
++ + S N TPL AA GHA +V +L+ S T + G T +H AA+
Sbjct: 189 TSYESCNITSYDNLFR--TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQ 246
Query: 1175 HGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVS 1234
+ V +++ S G T AA G + +R +LS +KS+ ++
Sbjct: 247 SNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLS-----LKSDIDINMA 301
Query: 1235 LVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSI 1294
+ G T LH AA +G+ + V+LLL + Q DA ++ + PL AC GH +
Sbjct: 302 ------DKYGGTALHAAALSGHVSTVKLLLEN-NAQVDA-TDVMKHTPLFRACEMGHKDV 353
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
+ L+ A + D+ G + LH A+ G+ + ++L+ N D G TPL CAA
Sbjct: 354 IQTLIKGGARV-DLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAA 412
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
G++N + +L E+ A P + + ++ + + D ++ LL
Sbjct: 413 YGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 457
Score = 148 bits (359), Expect = 2e-34
Identities = 139/525 (26%), Positives = 245/525 (46%), Gaps = 39/525 (7%)
Query: 896 YCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARV 955
YC +A D ++ + ADV++ + Q T L +A +G+ + + LLT A
Sbjct: 2 YCVLADRLDCADALLK--AGADVNKTDHSQR----TALHLAAQKGNYRFMKLLLTRRANW 55
Query: 956 DVFDVEGRSALHLAAEHGYLQVCDALLTNKA--FINSKARNGRTALHLAAMNGYAHLVKF 1013
D+E + LHL H + LL A ++++ +N +TALH +A VK
Sbjct: 56 MQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKL 115
Query: 1014 LIRDHNAMIDVLTLKKQTPLHLAAAS---GQIEVCKLLLELGAN---IDATDELGQKPIH 1067
LI+ H++ I + ++ + PLH AA + + +L+ ++ D G+ P+H
Sbjct: 116 LIK-HDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLH 174
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
A + VV + + + T H AA+ G +++ L++ +++G I +
Sbjct: 175 FAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSD 234
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
++ +TPL AA+ A+ V+V ++ + D + G T+ AA G +VL M S
Sbjct: 235 SQ--GATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSL 292
Query: 1188 NT-LRIS-SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGL 1245
+ + I+ + K G T LH AA G TV+ LL E V V+
Sbjct: 293 KSDIDINMADKYGGTALHAAALSGHVSTVKLLL---------ENNAQVDATDVMKH---- 339
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
TPL A G+++V++ L+ G + D +++G++ LH A GG+ + +L+
Sbjct: 340 TPLFRACEMGHKDVIQTLIKG-GARVDLV-DQDGHSLLHWAALGGNADVCQILIENKINP 397
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
+ D G+T L A+ G+ + VL+ A+ N DK G T LH + G+L+ +KLL
Sbjct: 398 -NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLL 456
Query: 1366 CESGASPKSETN--LNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
+ A P N P+ +A ++V++++L EH S+
Sbjct: 457 LDFAAFPNQMENNEERYTPLDYALLGERHEVIQFML--EHGALSI 499
Score = 129 bits (311), Expect = 1e-28
Identities = 131/478 (27%), Positives = 217/478 (45%), Gaps = 36/478 (7%)
Query: 746 CALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGE 805
CA LLK+GA NK T +H+AA+ GN + LLL + ++K +
Sbjct: 11 CADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKD-------LEEM 63
Query: 806 TPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIP 865
TPL + R P + L++F+ GE +D D++ +ALH++ E
Sbjct: 64 TPLHLTTRHRSPKCLALLLKFMA--PGE------VDTQDKNKQTALHWSAYYNNPE---- 111
Query: 866 TADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQ 925
VK LI++ +++ + + H+ A + + + + A LN Q
Sbjct: 112 -----HVKLLIKHDSNIGIPDVEG-KIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQ 165
Query: 926 NSIGWTPLLIACHRGHMQLVNTLLT-NHARVDVFDVEGRSALHLAAEHGYLQVCDALL-T 983
+ G TPL A G++ +V+ L + + +D R+ LH AA G+ Q+ LL
Sbjct: 166 DYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLER 225
Query: 984 NKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIE 1043
NK+ G T LH AA + +A VK ++ H ++ D L+ +T AA G +
Sbjct: 226 NKSGTIPSDSQGATPLHYAAQSNFAETVKVFLK-HPSVKDDSDLEGRTSFMWAAGKGSDD 284
Query: 1044 VCKLLLELGANID--ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAH 1101
V + +L L ++ID D+ G +HAAA + + V+L L+ + V AT +T
Sbjct: 285 VLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQ-VDATDVMKHTPLF 343
Query: 1102 IAAIQGSVKVIEELMKFD-RTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTD 1160
A G VI+ L+K R ++ + + L AA GG+ADV ++L+ +
Sbjct: 344 RACEMGHKDVIQTLIKGGARVDLVDQ----DGHSLLHWAALGGNADVCQILIENKINPNV 399
Query: 1161 ENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
++ AG T + AA G+ N + V+ N K G T LH + G + ++ LL
Sbjct: 400 QDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 457
Score = 122 bits (294), Expect = 1e-26
Identities = 124/479 (25%), Positives = 215/479 (44%), Gaps = 40/479 (8%)
Query: 680 NTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAAR 739
+ LL+ G V+ T + TALH+A + ++ LL A+ ++ + TPLH+ R
Sbjct: 13 DALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRAN-WMQKDLEEMTPLHLTTR 71
Query: 740 IPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVC 797
KC +LLK A T+D T +H +A + N + LL++ + +
Sbjct: 72 -HRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIK------HDSNIG 124
Query: 798 IYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKV 857
I D V G+ PL A P V H + + D + + + ++ D +G + LH+A V
Sbjct: 125 IPD-VEGKIPLHWAANHKDPSAV-HTVRCILD---AAPTESLLNWQDYEGRTPLHFA--V 177
Query: 858 TKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTAD 917
V + C I + ++ T H+ A+ G+ ++ ++ +
Sbjct: 178 ADGNVTVVDVLTSYESCNITSYDNL-------FRTPLHWAALLGHAQIVHLLLERNKSGT 230
Query: 918 VSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQV 977
+ +S G TPL A + V L + + D D+EGR++ AA G V
Sbjct: 231 IP-----SDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDV 285
Query: 978 CDALLTNKA--FINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHL 1035
+L+ K+ IN + G TALH AA++G+ VK L+ ++NA +D + K TPL
Sbjct: 286 LRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL-ENNAQVDATDVMKHTPLFR 344
Query: 1036 AAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKD 1095
A G +V + L++ GA +D D+ G +H AA ++V Q+ ++ N + +D
Sbjct: 345 ACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIE---NKINPNVQD 401
Query: 1096 --GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
G T AA G + + LM+ + I + T L + G+ D +++L+
Sbjct: 402 YAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK---EGRTALHWSCNNGYLDAIKLLL 457
Score = 118 bits (285), Expect = 2e-25
Identities = 117/439 (26%), Positives = 199/439 (45%), Gaps = 43/439 (9%)
Query: 666 SIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVET---LLGYGADV 722
++H +A Y + + L++ ++ + + LH A P+ V T +L
Sbjct: 100 ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTE 159
Query: 723 HIRGGKQRE--TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLA 778
+ + E TPLH A + DG+ + +L S N + D + TP+H AA G+
Sbjct: 160 SLLNWQDYEGRTPLHFA--VADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQ 217
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LLLE R I G TPL A +S + V+ + K SV
Sbjct: 218 IVHLLLE------RNKSGTIPSDSQGATPLHYAAQSNFAETVKVFL------KHPSVK-- 263
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
D D +G ++ +A ++V R ++ +++ D+++ ++ TA H A
Sbjct: 264 --DDSDLEGRTSFMWAAGKGSDDVL-----RTMLS--LKSDIDINMADKYGG-TALHAAA 313
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVF 958
++G+ + ++ + + D + + TPL AC GH ++ TL+ ARVD+
Sbjct: 314 LSGHVSTVKLLLENNAQVDATDVMKH------TPLFRACEMGHKDVIQTLIKGGARVDLV 367
Query: 959 DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH 1018
D +G S LH AA G VC L+ NK N + GRT L AA GY + + L+ ++
Sbjct: 368 DQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM-EN 426
Query: 1019 NAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA--NIDATDELGQKPIHAAAQNNYSE 1076
NA ++ + +T LH + +G ++ KLLL+ A N +E P+ A E
Sbjct: 427 NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHE 486
Query: 1077 VVQLFLQQHPNLVMATTKD 1095
V+Q F+ +H L +A +D
Sbjct: 487 VIQ-FMLEHGALSIAAIQD 504
Score = 68.1 bits (159), Expect = 3e-10
Identities = 49/164 (29%), Positives = 78/164 (47%), Gaps = 9/164 (5%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H AA GHV + LL+ VD T +T L A E V++TL+ GA V
Sbjct: 305 GGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARV 364
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + + LH AA + D C + L+++ PN G TP+ AA G + + +
Sbjct: 365 DL-VDQDGHSLLHWAALGGNADVCQI-LIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 422
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
L+E+ DP + K G T L +C + D ++ L++F
Sbjct: 423 LMENNADPNIQDK-------EGRTALHWSCNNGYLDAIKLLLDF 459
Score = 64.5 bits (150), Expect = 4e-09
Identities = 41/167 (24%), Positives = 79/167 (47%), Gaps = 1/167 (0%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ + A G+ ++R +LS ++ + G TALH AA V ++L++ A
Sbjct: 270 GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNA 329
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VDAT+ TPL A G + +++ A + D + + +H AA G+A + ++
Sbjct: 330 QVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQI 389
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L + K + + G T + A+ G+ +C +L + ++ +K
Sbjct: 390 LIEN-KINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK 435
Score = 62.1 bits (144), Expect = 2e-08
Identities = 41/129 (31%), Positives = 60/129 (46%), Gaps = 7/129 (5%)
Query: 98 GDTALHLAARRRD---VDMARILVDYGAVVDATNGA---GQTPLHIAAAEGDEPLVKYFY 151
G LH AA +D V R ++D N G+TPLH A A+G+ +V
Sbjct: 130 GKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLT 189
Query: 152 GVRA-NAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
+ N DN RTP+H AA GHA I+ LL ++ K+ G+T +H A+ +
Sbjct: 190 SYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNF 249
Query: 211 ADCAMMLFK 219
A+ + K
Sbjct: 250 AETVKVFLK 258
Score = 56.0 bits (129), Expect = 1e-06
Identities = 46/173 (26%), Positives = 75/173 (43%), Gaps = 3/173 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A +G+ S V+ LL + Q+ AT T L A D+ + L+ GA
Sbjct: 305 GGTALHAAALSGHVSTVKLLL--ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGA 362
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VD + G + LH AA G+ + + + N + D RTP+ AA G+ + +
Sbjct: 363 RVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 422
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQT 235
L + A + K+G T +H + NG+ D +L + + E+ T
Sbjct: 423 LMEN-NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYT 474
Score = 53.6 bits (123), Expect = 7e-06
Identities = 57/196 (29%), Positives = 86/196 (43%), Gaps = 21/196 (10%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY--TALHIAVESCKPAVVETLLGYG 719
+G S AA G ++ T+L +D+ D Y TALH A S + V+ LL
Sbjct: 269 EGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN 328
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
A V + TPL A + D L+K GA + +DG + +H AA GN
Sbjct: 329 AQVDAT-DVMKHTPLFRACEMGHKD-VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADV 386
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF 839
+L+E+ +P V Y G TPLQ A + + L+E + A
Sbjct: 387 CQILIENKINP----NVQDY---AGRTPLQCAAYGGYINCMAVLME----------NNAD 429
Query: 840 IDAVDEDGASALHYAC 855
+ D++G +ALH++C
Sbjct: 430 PNIQDKEGRTALHWSC 445
Score = 52.4 bits (120), Expect = 2e-05
Identities = 40/160 (25%), Positives = 74/160 (46%), Gaps = 4/160 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL A G+ +V LL + + + + G T LH AA+ + ++ + + +V
Sbjct: 204 RTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ-GATPLHYAAQSNFAETVKVFLKHPSV 262
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI--ADNEDRTPMHLAAENGHAAIIE 181
D ++ G+T AA +G + +++ ++++ I AD T +H AA +GH + ++
Sbjct: 263 KDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVK 322
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LL + A + T + A GH D L K G
Sbjct: 323 LLLEN-NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGG 361
Score = 49.6 bits (113), Expect = 1e-04
Identities = 38/161 (23%), Positives = 67/161 (41%), Gaps = 6/161 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL L + + LL ++ TALH +A + + ++L+ + + +
Sbjct: 65 PLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIG 124
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIA------DNEDRTPMHLAAENGHAAI 179
+ G+ PLH AA D V + A D E RTP+H A +G+ +
Sbjct: 125 IPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTV 184
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+++L +I T +H A+L GHA +L ++
Sbjct: 185 VDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLER 225
Score = 49.2 bits (112), Expect = 2e-04
Identities = 34/120 (28%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 111 VDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHL 170
+D A L+ GA V+ T+ + +T LH+AA +G+ +K RAN D E+ TP+HL
Sbjct: 9 LDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL 68
Query: 171 AAENGHAAIIELLADKFKA--SIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
+ + LL KF A + + K+ T +H ++ + + +L K + +P+
Sbjct: 69 TTRHRSPKCLALLL-KFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPD 127
>AK091555-1|BAC03695.1| 505|Homo sapiens protein ( Homo sapiens cDNA
FLJ34236 fis, clone FCBBF3027199, weakly similar to
ANKYRIN. ).
Length = 505
Score = 154 bits (374), Expect = 3e-36
Identities = 129/439 (29%), Positives = 203/439 (46%), Gaps = 27/439 (6%)
Query: 925 QNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTN 984
+++I +PL +A + GH + + TL +DV D +GR+AL LA E G + + L +
Sbjct: 10 ESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAH 69
Query: 985 KAFINSKARNGR-TALHLAAMNGYAHLVKFLI--RDHNAMIDVLTLKKQTPLHLAAASGQ 1041
A K R + T LH AA +G+ + LI + + DV+ + QTPL LA +G
Sbjct: 70 GASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDVYGQTPLMLAIMNGH 129
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAH 1101
++ LLLE G+ DA D G+ +H A + + L H V+ G T H
Sbjct: 130 VDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALL-DHDAFVLCRDFKGRTPIH 188
Query: 1102 IAAIQGSVKVIEELMKFD-RTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTD 1160
+A+ G V+ L++ T + A + +P+ A+ GH D + +L+
Sbjct: 189 LASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYL 248
Query: 1161 ENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI--SSKKLGLTPLHIAAYYGQAETVRELL 1218
E T +H A + + +++ +I S G TPLH AA+ +R LL
Sbjct: 249 EGNP-FTPLHCAVINNQDSTTEMLLGALGAKIVNSRDTKGRTPLHAAAFADNVSGLRMLL 307
Query: 1219 SHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQAD-AASNE 1277
H +A + +G T L AA NG V LL +AD +E
Sbjct: 308 QH-------QAEVNAT------DHTGRTALMTAAENGQTAAVEFLLYRG--KADLTVLDE 352
Query: 1278 NGYNPLHLACFGGHMSIVGLLLSRSAE--LLHSTDRHGKTGLHIASTHGHYQMVEVLLGQ 1335
N LHLAC GH ++L+ + + L+++T+ + LHIA+ +G +V+ LL
Sbjct: 353 NKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSH 412
Query: 1336 GAEINATDKNGWTP-LHCA 1353
GA + A D+ G TP L CA
Sbjct: 413 GATVLAVDEEGHTPALACA 431
Score = 149 bits (360), Expect = 1e-34
Identities = 127/420 (30%), Positives = 190/420 (45%), Gaps = 32/420 (7%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMID 1023
S LHLAA +G+ + L ++ + GRTAL LA G V+ L + +
Sbjct: 16 SPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALI 75
Query: 1024 VLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL---GQKPIHAAAQNNYSEVVQL 1080
+K TPLH AAASG + LL++ G D TD + GQ P+ A N + + V L
Sbjct: 76 KERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDVYGQTPLMLAIMNGHVDCVHL 135
Query: 1081 FLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAA 1140
L++ A + G T H A+ G + L+ D + R+ TP+ LA+
Sbjct: 136 LLEKGSTADAADLR-GRTALHRGAVTGCEDCLAALL--DHDAFVLCRD-FKGRTPIHLAS 191
Query: 1141 EGGHADVVRVLVRAGASCTDENRAGL-----TAVHLAAEHGHTNVLDVMRSTNTLRISSK 1195
GH V+R L++A S TD AG+ + +H A+ GH + L+++ +
Sbjct: 192 ACGHTAVLRTLLQAALS-TDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEG 250
Query: 1196 KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNG 1255
TPLH A Q T LL + + + T G TPLH AA+
Sbjct: 251 N-PFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDT-----------KGRTPLHAAAFAD 298
Query: 1256 NENVVRLLLNSAGVQADA-ASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGK 1314
N + +R+LL QA+ A++ G L A G + V LL R L D +
Sbjct: 299 NVSGLRMLLQH---QAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKN 355
Query: 1315 TGLHIASTHGHYQMVEVLLGQGAE---INATDKNGWTPLHCAAKAGHLNVVKLLCESGAS 1371
T LH+A + GH + ++L + + INAT+ PLH AA+ G +VV+ L GA+
Sbjct: 356 TALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGAT 415
Score = 144 bits (348), Expect = 4e-33
Identities = 112/389 (28%), Positives = 175/389 (44%), Gaps = 16/389 (4%)
Query: 1019 NAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVV 1078
N + DV + +PLHLAA +G E K L E N+D D G+ + A + +E V
Sbjct: 4 NCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECV 63
Query: 1079 QLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQL 1138
++ + ++ K T H AA G + L+ I+ + TPL L
Sbjct: 64 EVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDVYGQTPLML 123
Query: 1139 AAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLG 1198
A GH D V +L+ G++ + G TA+H A G + L + + + G
Sbjct: 124 AIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKG 183
Query: 1199 LTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNEN 1258
TP+H+A+ G +R LL T +A GV SG +P+H A+Y G+E+
Sbjct: 184 RTPIHLASACGHTAVLRTLLQAALSTDPLDA--GVDY-------SGYSPMHWASYTGHED 234
Query: 1259 VVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLL-SRSAELLHSTDRHGKTGL 1317
+ LLL + + N + PLH A S +LL + A++++S D G+T L
Sbjct: 235 CLELLLEHSPF---SYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDTKGRTPL 291
Query: 1318 HIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKS--E 1375
H A+ + + +LL AE+NATD G T L AA+ G V+ L G + + +
Sbjct: 292 HAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLD 351
Query: 1376 TNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
N N A + A S+ H +L + D
Sbjct: 352 ENKNTA-LHLACSKGHEKCALMILAETQD 379
Score = 127 bits (307), Expect = 4e-28
Identities = 105/377 (27%), Positives = 173/377 (45%), Gaps = 25/377 (6%)
Query: 1056 DATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEEL 1115
D + P+H AA N + E ++ + NL + K G T +A +GS + +E L
Sbjct: 8 DVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHK-GRTALFLATERGSTECVEVL 66
Query: 1116 MKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAG--ASCTDENRA-GLTAVHLA 1172
+ +I R + TPL AA GH D + +L+ +G A TD G T + LA
Sbjct: 67 TAHGASALIKERKR--KWTPLHAAAASGHTDSLHLLIDSGERADITDVMDVYGQTPLMLA 124
Query: 1173 AEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
+GH + + ++ + ++ G T LH A G + + LL H + +
Sbjct: 125 IMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDF--- 181
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSA--GVQADAASNENGYNPLHLACFGG 1290
G TP+HLA+ G+ V+R LL +A DA + +GY+P+H A + G
Sbjct: 182 ----------KGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTG 231
Query: 1291 HMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQ-GAEI-NATDKNGWT 1348
H + LLL S + + T LH A + E+LLG GA+I N+ D G T
Sbjct: 232 HEDCLELLLEHSP--FSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDTKGRT 289
Query: 1349 PLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
PLH AA A +++ +++L + A + + + AA +E+LL++ ++
Sbjct: 290 PLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTV 349
Query: 1409 MDDKRFVYNLMVCSKNH 1425
+D+ + + CSK H
Sbjct: 350 LDENKNTALHLACSKGH 366
Score = 124 bits (300), Expect = 3e-27
Identities = 105/361 (29%), Positives = 169/361 (46%), Gaps = 19/361 (5%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
+ V+ L +GA ++ R T H A +G+ D + +I AD++ ++ G
Sbjct: 61 ECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMD---VYG 117
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
TPL++A GH+ V+ LL + D D+ GR+ALH A G ALL + AF+
Sbjct: 118 QTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVL 177
Query: 990 SKARNGRTALHLAAMNGYAHLVKFLIR---DHNAMIDVLTLKKQTPLHLAAASGQIEVCK 1046
+ GRT +HLA+ G+ +++ L++ + + + +P+H A+ +G + +
Sbjct: 178 CRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLE 237
Query: 1047 LLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL-QQHPNLVMATTKDGNTCAHIAAI 1105
LLLE + + P+H A NN ++ L +V + G T H AA
Sbjct: 238 LLLE-HSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDTKGRTPLHAAAF 296
Query: 1106 QGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV---RAGASCTDEN 1162
+V + L++ ++A + T L AAE G V L+ +A + DEN
Sbjct: 297 ADNVSGLRMLLQ--HQAEVNATDH-TGRTALMTAAENGQTAAVEFLLYRGKADLTVLDEN 353
Query: 1163 RAGLTAVHLAAEHGHTN-VLDVMRSTNTL-RISSKKLGL-TPLHIAAYYGQAETVRELLS 1219
+ TA+HLA GH L ++ T L I++ L PLHIAA G A V+ LLS
Sbjct: 354 KN--TALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLS 411
Query: 1220 H 1220
H
Sbjct: 412 H 412
Score = 122 bits (294), Expect = 1e-26
Identities = 128/438 (29%), Positives = 187/438 (42%), Gaps = 54/438 (12%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA GH + TL + ++DV + TAL +A E VE L +GA I+
Sbjct: 18 LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 77
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNLATLVLLL 784
K++ TPLH AA D L++ D G TP+ +A G++ + LLL
Sbjct: 78 RKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDVYGQTPLMLAIMNGHVDCVHLLL 137
Query: 785 EDGGDP----LRKTKVCIYDVVTGETPLQMACRSCMPDIVRH-LIEFVKDHKGES----- 834
E G LR VTG C C+ ++ H +D KG +
Sbjct: 138 EKGSTADAADLRGRTALHRGAVTG-------CEDCLAALLDHDAFVLCRDFKGRTPIHLA 190
Query: 835 ----------------VSTAFIDA-VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIE 877
+ST +DA VD G S +H+A E+ ++ L+E
Sbjct: 191 SACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDC---------LELLLE 241
Query: 878 NGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIAC 937
+ L+ N T H CA+ N D TEM+ A + +N +++ G TPL A
Sbjct: 242 HSPFSYLEG--NPFTPLH-CAVINNQDSTTEMLLGALGAKI---VNSRDTKGRTPLHAAA 295
Query: 938 HRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALL-TNKAFINSKARNGR 996
++ + LL + A V+ D GR+AL AAE+G + LL KA + N
Sbjct: 296 FADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKN 355
Query: 997 TALHLAAMNGYAHLVKFLIRDHN--AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
TALHLA G+ ++ + +I+ Q PLH+AA +G V + LL GA
Sbjct: 356 TALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGAT 415
Query: 1055 IDATDELGQKPIHAAAQN 1072
+ A DE G P A A N
Sbjct: 416 VLAVDEEGHTPALACAPN 433
Score = 78.2 bits (184), Expect = 3e-13
Identities = 77/256 (30%), Positives = 114/256 (44%), Gaps = 31/256 (12%)
Query: 1186 STNTLRISSKKLGLTPLHIAAYYGQAETVRELL---------SHVPGTVKSEAPT--GVS 1234
S N L + ++PLH+AAY G E ++ L H T A
Sbjct: 2 SFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTE 61
Query: 1235 LVPVLGAE--SGL--------TPLHLAAYNGNENVVRLLLNSAGVQADAAS--NENGYNP 1282
V VL A S L TPLH AA +G+ + + LL++S G +AD + G P
Sbjct: 62 CVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDS-GERADITDVMDVYGQTP 120
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINAT 1342
L LA GH+ V LLL + + + D G+T LH + G + LL A +
Sbjct: 121 LMLAIMNGHVDCVHLLLEKGS-TADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCR 179
Query: 1343 DKNGWTPLHCAAKAGHLNVVKLLCESGASPKS-ETNLN---CAPIWFAASENHNDVLEYL 1398
D G TP+H A+ GH V++ L ++ S + ++ +P+ +A+ H D LE L
Sbjct: 180 DFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELL 239
Query: 1399 LHKEHDTQSLMDDKRF 1414
L EH S ++ F
Sbjct: 240 L--EHSPFSYLEGNPF 253
Score = 72.1 bits (169), Expect = 2e-11
Identities = 57/190 (30%), Positives = 81/190 (42%), Gaps = 9/190 (4%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELL-SAQTAEQLKATTPAGDTALHLAARRRDVDMARILVD 119
+R PL A +G+ + L+ S + A+ G T L LA VD +L++
Sbjct: 79 KRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDVYGQTPLMLAIMNGHVDCVHLLLE 138
Query: 120 YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
G+ DA + G+T LH A G E + A D + RTP+HLA+ GH A+
Sbjct: 139 KGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAV 198
Query: 180 IE-LLADKFKASIFERTKD--GSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTF 236
+ LL + D G + MH AS GH DC +L + H P Y E F
Sbjct: 199 LRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE-----HSPFSYLEGNPF 253
Query: 237 DEVLFVKIEN 246
+ I N
Sbjct: 254 TPLHCAVINN 263
Score = 68.9 bits (161), Expect = 2e-10
Identities = 49/159 (30%), Positives = 72/159 (45%), Gaps = 3/159 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL AV S LL A A+ + + G T LH AA +V R+L+ + A V+
Sbjct: 255 PLHCAVINNQDSTTEMLLGALGAKIVNSRDTKGRTPLHAAAFADNVSGLRMLLQHQAEVN 314
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKY-FYGVRANAAIADNEDRTPMHLAAENGH-AAIIELL 183
AT+ G+T L AA G V++ Y +A+ + D T +HLA GH + +L
Sbjct: 315 ATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMIL 374
Query: 184 ADKFKASIFERTKDGSTL-MHIASLNGHADCAMMLFKKG 221
A+ + T + +HIA+ NG A L G
Sbjct: 375 AETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHG 413
Score = 65.7 bits (153), Expect = 2e-09
Identities = 42/142 (29%), Positives = 69/142 (48%), Gaps = 5/142 (3%)
Query: 83 LSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEG 142
+S E +++T P + LHLAA + + L + +D + G+T L +A G
Sbjct: 1 MSFNCLEDVESTIPV--SPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERG 58
Query: 143 DEPLVKYFYGVRANAAIADNEDR-TPMHLAAENGHAAIIELLADKFKASIFERTKD--GS 199
V+ A+A I + + + TP+H AA +GH + LL D + + D G
Sbjct: 59 STECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDVYGQ 118
Query: 200 TLMHIASLNGHADCAMMLFKKG 221
T + +A +NGH DC +L +KG
Sbjct: 119 TPLMLAIMNGHVDCVHLLLEKG 140
Score = 62.5 bits (145), Expect = 2e-08
Identities = 44/151 (29%), Positives = 70/151 (46%), Gaps = 4/151 (2%)
Query: 100 TALHLAA-RRRDVDMARILVDYGA-VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
T LH A +D +L GA +V++ + G+TPLH AA + ++ +A
Sbjct: 254 TPLHCAVINNQDSTTEMLLGALGAKIVNSRDTKGRTPLHAAAFADNVSGLRMLLQHQAEV 313
Query: 158 AIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
D+ RT + AAENG A +E L + KA + ++ +T +H+A GH CA+M+
Sbjct: 314 NATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMI 373
Query: 218 FKKGVYLHMPNKYFEKQTFDEVLFVKIENGL 248
+ L + N L + NGL
Sbjct: 374 LAETQDLGLINA--TNSALQMPLHIAARNGL 402
Score = 61.7 bits (143), Expect = 3e-08
Identities = 50/157 (31%), Positives = 67/157 (42%), Gaps = 5/157 (3%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D+ +G+ L LA E G+ V E+L+A A L T LH AA D +
Sbjct: 41 DVRDHKGRTALFLATERGSTECV-EVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHL 99
Query: 117 LVDYGA---VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAE 173
L+D G + D + GQTPL +A G V + A AD RT +H A
Sbjct: 100 LIDSGERADITDVMDVYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAV 159
Query: 174 NGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
G + L D A + R G T +H+AS GH
Sbjct: 160 TGCEDCLAALLD-HDAFVLCRDFKGRTPIHLASACGH 195
Score = 58.4 bits (135), Expect = 3e-07
Identities = 49/167 (29%), Positives = 74/167 (44%), Gaps = 8/167 (4%)
Query: 55 IRDLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMA 114
I D++ G+ PL+LA+ G+ V LL + A G TALH A D
Sbjct: 109 ITDVMDVYGQTPLMLAIMNGHVDCVHLLL--EKGSTADAADLRGRTALHRGAVTGCEDCL 166
Query: 115 RILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA----AIADNEDRTPMHL 170
L+D+ A V + G+TP+H+A+A G +++ + A D +PMH
Sbjct: 167 AALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHW 226
Query: 171 AAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
A+ GH +ELL + S E + T +H A +N ML
Sbjct: 227 ASYTGHEDCLELLLEHSPFSYLE--GNPFTPLHCAVINNQDSTTEML 271
Score = 54.8 bits (126), Expect = 3e-06
Identities = 62/209 (29%), Positives = 92/209 (44%), Gaps = 25/209 (11%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDV----TTNDNYTALHIAVESCKPAVVET 714
+ F G IH A+ GH ++ TLLQ S D Y+ +H A + +E
Sbjct: 179 RDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLEL 238
Query: 715 LLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKS-GAG-PNKATEDGMTPVHVAA 772
LL + ++ G TPLH A I + D MLL + GA N G TP+H AA
Sbjct: 239 LLEHSPFSYLEGNP--FTPLHCAV-INNQDSTTEMLLGALGAKIVNSRDTKGRTPLHAAA 295
Query: 773 KFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKG 832
N++ L +LL+ + +V D TG T L A + V L+ ++G
Sbjct: 296 FADNVSGLRMLLQ------HQAEVNATD-HTGRTALMTAAENGQTAAVEFLL-----YRG 343
Query: 833 ESVSTAFIDAVDEDGASALHYACKVTKEE 861
+ A + +DE+ +ALH AC E+
Sbjct: 344 K----ADLTVLDENKNTALHLACSKGHEK 368
Score = 49.2 bits (112), Expect = 2e-04
Identities = 40/120 (33%), Positives = 54/120 (45%), Gaps = 6/120 (5%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV---- 118
G+ L+ A E G + V LL A+ L +TALHLA + A +++
Sbjct: 320 GRTALMTAAENGQTAAVEFLLYRGKAD-LTVLDENKNTALHLACSKGHEKCALMILAETQ 378
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
D G +++ATN A Q PLHIAA G +V+ A D E TP A N A
Sbjct: 379 DLG-LINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVA 437
>BC110618-1|AAI10619.1| 784|Homo sapiens receptor-interacting
serine-threonine kinase 4 protein.
Length = 784
Score = 152 bits (369), Expect = 1e-35
Identities = 113/377 (29%), Positives = 182/377 (48%), Gaps = 23/377 (6%)
Query: 907 TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSAL 966
++++ + DV AL+ S+ L +A G + LL N+A ++ + G + L
Sbjct: 420 SKLMKILQPQDVDLALDSGASL----LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL 475
Query: 967 HLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
H+A E V + LL K +N+K + TALH AA NG + L+ + NA ++ +
Sbjct: 476 HMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLL-EKNASVNEVD 534
Query: 1027 LKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP 1086
+ +TP+H+A GQ + ++LL G ++ + P+H AA + +V+L +Q
Sbjct: 535 FEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPG 594
Query: 1087 NLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHAD 1146
V A T DG T H+AA +G +V L+ D ++ + L TPL +AAE GH
Sbjct: 595 VSVNAQTLDGRTPLHLAAQRGHYRVARILI--DLCSDVNVCSLLAQ-TPLHVAAETGHTS 651
Query: 1147 VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
R+L+ GA G TA+HLAA +GH + ++ ++ L T LH+AA
Sbjct: 652 TARLLLHRGAGKEAVTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAA 711
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLL-N 1265
+G +E V EL+S + V L E GL+ LHLAA + V LL +
Sbjct: 712 AHGHSEVVEELVS--------------ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRH 757
Query: 1266 SAGVQADAASNENGYNP 1282
A + + + G+ P
Sbjct: 758 GAHINLQSLKFQGGHGP 774
Score = 149 bits (360), Expect = 1e-34
Identities = 105/346 (30%), Positives = 168/346 (48%), Gaps = 23/346 (6%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+D + GAS LH A + +EE K L+ N A+ +L R T H
Sbjct: 431 VDLALDSGASLLHLAVEAGQEEC---------AKWLLLNNANPNLSNRRG-STPLHMAVE 480
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
V+ ++A ++N ++ WT L A G LL +A V+ D
Sbjct: 481 RRVRGVVELLLAR------KISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
EGR+ +H+A +HG + LL ++ + ++ LH AA G+ +VK L +
Sbjct: 535 FEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPG 594
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
++ TL +TPLHLAA G V ++L++L ++++ L Q P+H AA+ ++ +
Sbjct: 595 VSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTAR 654
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLA 1139
L L + A T DG T H+AA G + ++ L++ ++ V+ AR LN T L LA
Sbjct: 655 LLLHRGAG-KEAVTSDGYTALHLAARNGHLATVKLLVE-EKADVL-ARGPLN-QTALHLA 710
Query: 1140 AEGGHADVVRVLVRAGA-SCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
A GH++VV LV A DE GL+A+HLAA+ H ++ +
Sbjct: 711 AAHGHSEVVEELVSADVIDLFDEQ--GLSALHLAAQGRHAQTVETL 754
Score = 137 bits (331), Expect = 5e-31
Identities = 115/349 (32%), Positives = 164/349 (46%), Gaps = 25/349 (7%)
Query: 994 NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA 1053
+G + LHLA G K+L+ + NA ++ + TPLH+A V +LLL
Sbjct: 437 SGASLLHLAVEAGQEECAKWLLLN-NANPNLSNRRGSTPLHMAVERRVRGVVELLLARKI 495
Query: 1054 NIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIE 1113
+++A DE +H AAQN +L L+++ + V +G T H+A G ++
Sbjct: 496 SVNAKDEDQWTALHFAAQNGDESSTRLLLEKNAS-VNEVDFEGRTPMHVACQHGQENIVR 554
Query: 1114 ELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLA 1172
L+ R GV + + PL AA GH +V++L + G S + G T +HLA
Sbjct: 555 ILL---RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLA 611
Query: 1173 AEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
A+ GH V ++ + L TPLH+AA G T R LL G EA T
Sbjct: 612 AQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAG---KEAVTS 668
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS-AGVQADAASNENGYNPLHLACFGGH 1291
G T LHLAA NG+ V+LL+ A V A N+ LHLA GH
Sbjct: 669 ----------DGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTA---LHLAAAHGH 715
Query: 1292 MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN 1340
+V L+S A+++ D G + LH+A+ H Q VE LL GA IN
Sbjct: 716 SEVVEELVS--ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
Score = 122 bits (295), Expect = 1e-26
Identities = 111/361 (30%), Positives = 172/361 (47%), Gaps = 35/361 (9%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
LH+A ++CA LL + A PN + G TP+H+A + + LLL RK
Sbjct: 442 LHLAVEAGQ-EECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLL------ARK 494
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHY 853
V D T L A ++ R L+E A ++ VD +G + +H
Sbjct: 495 ISVNAKD-EDQWTALHFAAQNGDESSTRLLLE----------KNASVNEVDFEGRTPMHV 543
Query: 854 ACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHI 913
AC+ +E +V+ L+ G DVSLQ + + HY A G+ ++ +++A
Sbjct: 544 ACQHGQE---------NIVRILLRRGVDVSLQGK-DAWLPLHYAAWQGHLPIV-KLLA-- 590
Query: 914 STADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHG 973
VS +N Q G TPL +A RGH ++ L+ + V+V + ++ LH+AAE G
Sbjct: 591 KQPGVS--VNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETG 648
Query: 974 YLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPL 1033
+ LL A + +G TALHLAA NG+ VK L+ + ++ L QT L
Sbjct: 649 HTSTARLLLHRGAGKEAVTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPL-NQTAL 707
Query: 1034 HLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT 1093
HLAAA G EV + L+ ID DE G +H AAQ +++ V+ L+ ++ + +
Sbjct: 708 HLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSL 766
Query: 1094 K 1094
K
Sbjct: 767 K 767
Score = 121 bits (292), Expect = 2e-26
Identities = 87/334 (26%), Positives = 155/334 (46%), Gaps = 17/334 (5%)
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK 1195
L LA E G + + L+ A+ NR G T +H+A E V++++ + +
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
Query: 1196 KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNG 1255
+ T LH AA G + R LL K+ + V G TP+H+A +G
Sbjct: 502 EDQWTALHFAAQNGDESSTRLLLE------KNASVNEVDF-------EGRTPMHVACQHG 548
Query: 1256 NENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKT 1315
EN+VR+LL GV + ++ + PLH A + GH+ IV LL + +++ G+T
Sbjct: 549 QENIVRILLRR-GVDV-SLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRT 606
Query: 1316 GLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSE 1375
LH+A+ GHY++ +L+ +++N TPLH AA+ GH + +LL GA ++
Sbjct: 607 PLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAV 666
Query: 1376 TNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVL 1435
T+ + AA H ++ L+ ++ D + + +L + H+ + +EE V
Sbjct: 667 TSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHL-AAAHGHSEV-VEELVS 724
Query: 1436 VSPAPVDTAAKLSNIYINLSTKEKERAKDLIAAG 1469
+ LS +++ + + + L+ G
Sbjct: 725 ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHG 758
Score = 105 bits (251), Expect = 2e-21
Identities = 107/371 (28%), Positives = 173/371 (46%), Gaps = 38/371 (10%)
Query: 687 ESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKC 746
+ VD+ + + LH+AVE+ + + LL A+ ++ ++ TPLH+A
Sbjct: 429 QDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNL-SNRRGSTPLHMAVERRVRGVV 487
Query: 747 ALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGET 806
L+L + N ED T +H AA+ G+ ++ LLLE + V D G T
Sbjct: 488 ELLLARK-ISVNAKDEDQWTALHFAAQNGDESSTRLLLE------KNASVNEVD-FEGRT 539
Query: 807 PLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPT 866
P+ +AC+ +IVR L+ +G VS +D LHYA + +P
Sbjct: 540 PMHVACQHGQENIVRILL-----RRGVDVSLQ-----GKDAWLPLHYAA----WQGHLP- 584
Query: 867 ADRQVVKCLIEN-GADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQ 925
+VK L + G V+ QT + T H A G+ V +I D+ +N
Sbjct: 585 ----IVKLLAKQPGVSVNAQTL-DGRTPLHLAAQRGHYRVARILI------DLCSDVNVC 633
Query: 926 NSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNK 985
+ + TPL +A GH LL A + +G +ALHLAA +G+L L+ K
Sbjct: 634 SLLAQTPLHVAAETGHTSTARLLLHRGAGKEAVTSDGYTALHLAARNGHLATVKLLVEEK 693
Query: 986 AFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVC 1045
A + ++ +TALHLAA +G++ +V+ L+ +ID+ + + LHLAA +
Sbjct: 694 ADVLARGPLNQTALHLAAAHGHSEVVEELVSAD--VIDLFDEQGLSALHLAAQGRHAQTV 751
Query: 1046 KLLLELGANID 1056
+ LL GA+I+
Sbjct: 752 ETLLRHGAHIN 762
Score = 92.3 bits (219), Expect = 2e-17
Identities = 105/368 (28%), Positives = 161/368 (43%), Gaps = 36/368 (9%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
GA +H A G LL + +++ T LH+AVE VVE LL V
Sbjct: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + + + T LH AA+ D + +LL+ A N+ +G TP+HVA + G + +
Sbjct: 498 NAK-DEDQWTALHFAAQNGD-ESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRI 555
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL G D + K PL A IV+ L K VS ++A
Sbjct: 556 LLRRGVDVSLQGK-------DAWLPLHYAAWQGHLPIVKLLA------KQPGVS---VNA 599
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
DG + LH A + +V + LI+ +DV++ + +T H A G+
Sbjct: 600 QTLDGRTPLHLAAQ---------RGHYRVARILIDLCSDVNVCSL-LAQTPLHVAAETGH 649
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
++ H S G+T L +A GH+ V L+ A V
Sbjct: 650 TST-ARLLLHRGAGK-----EAVTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLN 703
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
++ALHLAA HG+ +V + L++ I+ G +ALHLAA +A V+ L+R H A I
Sbjct: 704 QTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLR-HGAHI 761
Query: 1023 DVLTLKKQ 1030
++ +LK Q
Sbjct: 762 NLQSLKFQ 769
Score = 91.9 bits (218), Expect = 2e-17
Identities = 89/299 (29%), Positives = 137/299 (45%), Gaps = 35/299 (11%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K D ++H AA+ G LL+K SV+ + T +H+A + + +V LL
Sbjct: 500 KDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR 559
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
G DV ++ GK PLH AA L+ + G N T DG TP+H+AA+ G+
Sbjct: 560 GVDVSLQ-GKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYR 618
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+L++ D VC + +TPL +A + R L+ H+G A
Sbjct: 619 VARILIDLCSD----VNVC---SLLAQTPLHVAAETGHTSTARLLL-----HRG-----A 661
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
+AV DG +ALH A + VK L+E ADV + N +TA H A
Sbjct: 662 GKEAVTSDGYTALHLAAR---------NGHLATVKLLVEEKADVLARGPLN-QTALHLAA 711
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
G+++V+ E++ +ADV + Q G + L +A H Q V TLL + A +++
Sbjct: 712 AHGHSEVVEELV----SADVIDLFDEQ---GLSALHLAAQGRHAQTVETLLRHGAHINL 763
Score = 87.8 bits (208), Expect = 4e-16
Identities = 51/157 (32%), Positives = 83/157 (52%), Gaps = 2/157 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+RG PL +AVE + +V LL+ + + K TALH AA+ D R+L++
Sbjct: 469 RRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQW--TALHFAAQNGDESSTRLLLEK 526
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A V+ + G+TP+H+A G E +V+ + ++ + P+H AA GH I+
Sbjct: 527 NASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIV 586
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+LLA + S+ +T DG T +H+A+ GH A +L
Sbjct: 587 KLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARIL 623
Score = 87.4 bits (207), Expect = 5e-16
Identities = 52/148 (35%), Positives = 80/148 (54%), Gaps = 2/148 (1%)
Query: 65 VPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVV 124
+PL A G+ +V+ LL+ Q + A T G T LHLAA+R +ARIL+D + V
Sbjct: 572 LPLHYAAWQGHLPIVK-LLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDV 630
Query: 125 DATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
+ + QTPLH+AA G + A ++ T +HLAA NGH A ++LL
Sbjct: 631 NVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAVTSDGYTALHLAARNGHLATVKLLV 690
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHAD 212
++ KA + R T +H+A+ +GH++
Sbjct: 691 EE-KADVLARGPLNQTALHLAAAHGHSE 717
Score = 81.4 bits (192), Expect = 3e-14
Identities = 52/161 (32%), Positives = 79/161 (49%), Gaps = 5/161 (3%)
Query: 1239 LGAESGLTPLHLAAYNGNENVVR-LLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGL 1297
L +SG + LHLA G E + LLLN+A SN G PLH+A +V L
Sbjct: 433 LALDSGASLLHLAVEAGQEECAKWLLLNNANPN---LSNRRGSTPLHMAVERRVRGVVEL 489
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
LL+R +++ D T LH A+ +G +LL + A +N D G TP+H A + G
Sbjct: 490 LLARKIS-VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHG 548
Query: 1358 HLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYL 1398
N+V++L G + P+ +AA + H +++ L
Sbjct: 549 QENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLL 589
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/170 (27%), Positives = 82/170 (48%), Gaps = 4/170 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ PL LA + G+ + R L+ + + T LH+AA AR+L+ GA
Sbjct: 604 GRTPLHLAAQRGHYRVARILIDL--CSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGA 661
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+A G T LH+AA G VK +A+ ++T +HLAA +GH+ ++E
Sbjct: 662 GKEAVTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEE 721
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFE 232
L +F+ + G + +H+A+ HA L + G ++++ + F+
Sbjct: 722 LVSADVIDLFD--EQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQ 769
Score = 72.9 bits (171), Expect = 1e-11
Identities = 51/164 (31%), Positives = 74/164 (45%), Gaps = 3/164 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
DL G L LAVEAG + + LL L + G T LH+A RR + +
Sbjct: 432 DLALDSGASLLHLAVEAGQEECAKWLLLNNANPNL--SNRRGSTPLHMAVERRVRGVVEL 489
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+ V+A + T LH AA GDE + A+ D E RTPMH+A ++G
Sbjct: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
I+ +L + + + KD +H A+ GH +L K+
Sbjct: 550 ENIVRILLRR-GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQ 592
Score = 69.7 bits (163), Expect = 1e-10
Identities = 46/166 (27%), Positives = 81/166 (48%), Gaps = 4/166 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
K L+ A+ +G+ S + ++L Q + +G + LHLA + A+ L+ A
Sbjct: 407 KKKLVDAIVSGDTSKLMKILQPQDVD---LALDSGASLLHLAVEAGQEECAKWLLLNNAN 463
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
+ +N G TPLH+A +V+ + + D + T +H AA+NG + LL
Sbjct: 464 PNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLL 523
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+K AS+ E +G T MH+A +G + +L ++GV + + K
Sbjct: 524 LEK-NASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGK 568
Score = 59.3 bits (137), Expect = 1e-07
Identities = 39/128 (30%), Positives = 61/128 (47%), Gaps = 1/128 (0%)
Query: 1277 ENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG 1336
++G + LHLA G LL +A + ++R G T LH+A +VE+LL +
Sbjct: 436 DSGASLLHLAVEAGQEECAKWLLLNNANP-NLSNRRGSTPLHMAVERRVRGVVELLLARK 494
Query: 1337 AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLE 1396
+NA D++ WT LH AA+ G + +LL E AS P+ A +++
Sbjct: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554
Query: 1397 YLLHKEHD 1404
LL + D
Sbjct: 555 ILLRRGVD 562
>BC110617-1|AAI10618.1| 784|Homo sapiens receptor-interacting
serine-threonine kinase 4 protein.
Length = 784
Score = 152 bits (369), Expect = 1e-35
Identities = 113/377 (29%), Positives = 182/377 (48%), Gaps = 23/377 (6%)
Query: 907 TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSAL 966
++++ + DV AL+ S+ L +A G + LL N+A ++ + G + L
Sbjct: 420 SKLMKILQPQDVDLALDSGASL----LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL 475
Query: 967 HLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
H+A E V + LL K +N+K + TALH AA NG + L+ + NA ++ +
Sbjct: 476 HMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLL-EKNASVNEVD 534
Query: 1027 LKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP 1086
+ +TP+H+A GQ + ++LL G ++ + P+H AA + +V+L +Q
Sbjct: 535 FEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPG 594
Query: 1087 NLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHAD 1146
V A T DG T H+AA +G +V L+ D ++ + L TPL +AAE GH
Sbjct: 595 VSVNAQTLDGRTPLHLAAQRGHYRVARILI--DLCSDVNVCSLLAQ-TPLHVAAETGHTS 651
Query: 1147 VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
R+L+ GA G TA+HLAA +GH + ++ ++ L T LH+AA
Sbjct: 652 TARLLLHRGAGKEAVTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAA 711
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLL-N 1265
+G +E V EL+S + V L E GL+ LHLAA + V LL +
Sbjct: 712 AHGHSEVVEELVS--------------ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRH 757
Query: 1266 SAGVQADAASNENGYNP 1282
A + + + G+ P
Sbjct: 758 GAHINLQSLKFQGGHGP 774
Score = 149 bits (360), Expect = 1e-34
Identities = 105/346 (30%), Positives = 168/346 (48%), Gaps = 23/346 (6%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+D + GAS LH A + +EE K L+ N A+ +L R T H
Sbjct: 431 VDLALDSGASLLHLAVEAGQEEC---------AKWLLLNNANPNLSNRRG-STPLHMAVE 480
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
V+ ++A ++N ++ WT L A G LL +A V+ D
Sbjct: 481 RRVRGVVELLLAR------KISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
EGR+ +H+A +HG + LL ++ + ++ LH AA G+ +VK L +
Sbjct: 535 FEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPG 594
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
++ TL +TPLHLAA G V ++L++L ++++ L Q P+H AA+ ++ +
Sbjct: 595 VSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTAR 654
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLA 1139
L L + A T DG T H+AA G + ++ L++ ++ V+ AR LN T L LA
Sbjct: 655 LLLHRGAG-KEAVTSDGYTALHLAARNGHLATVKLLVE-EKADVL-ARGPLN-QTALHLA 710
Query: 1140 AEGGHADVVRVLVRAGA-SCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
A GH++VV LV A DE GL+A+HLAA+ H ++ +
Sbjct: 711 AAHGHSEVVEELVSADVIDLFDEQ--GLSALHLAAQGRHAQTVETL 754
Score = 137 bits (331), Expect = 5e-31
Identities = 115/349 (32%), Positives = 164/349 (46%), Gaps = 25/349 (7%)
Query: 994 NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA 1053
+G + LHLA G K+L+ + NA ++ + TPLH+A V +LLL
Sbjct: 437 SGASLLHLAVEAGQEECAKWLLLN-NANPNLSNRRGSTPLHMAVERRVRGVVELLLARKI 495
Query: 1054 NIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIE 1113
+++A DE +H AAQN +L L+++ + V +G T H+A G ++
Sbjct: 496 SVNAKDEDQWTALHFAAQNGDESSTRLLLEKNAS-VNEVDFEGRTPMHVACQHGQENIVR 554
Query: 1114 ELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLA 1172
L+ R GV + + PL AA GH +V++L + G S + G T +HLA
Sbjct: 555 ILL---RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLA 611
Query: 1173 AEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
A+ GH V ++ + L TPLH+AA G T R LL G EA T
Sbjct: 612 AQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAG---KEAVTS 668
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS-AGVQADAASNENGYNPLHLACFGGH 1291
G T LHLAA NG+ V+LL+ A V A N+ LHLA GH
Sbjct: 669 ----------DGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTA---LHLAAAHGH 715
Query: 1292 MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN 1340
+V L+S A+++ D G + LH+A+ H Q VE LL GA IN
Sbjct: 716 SEVVEELVS--ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
Score = 122 bits (295), Expect = 1e-26
Identities = 111/361 (30%), Positives = 172/361 (47%), Gaps = 35/361 (9%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
LH+A ++CA LL + A PN + G TP+H+A + + LLL RK
Sbjct: 442 LHLAVEAGQ-EECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLL------ARK 494
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHY 853
V D T L A ++ R L+E A ++ VD +G + +H
Sbjct: 495 ISVNAKD-EDQWTALHFAAQNGDESSTRLLLE----------KNASVNEVDFEGRTPMHV 543
Query: 854 ACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHI 913
AC+ +E +V+ L+ G DVSLQ + + HY A G+ ++ +++A
Sbjct: 544 ACQHGQE---------NIVRILLRRGVDVSLQGK-DAWLPLHYAAWQGHLPIV-KLLA-- 590
Query: 914 STADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHG 973
VS +N Q G TPL +A RGH ++ L+ + V+V + ++ LH+AAE G
Sbjct: 591 KQPGVS--VNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETG 648
Query: 974 YLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPL 1033
+ LL A + +G TALHLAA NG+ VK L+ + ++ L QT L
Sbjct: 649 HTSTARLLLHRGAGKEAVTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPL-NQTAL 707
Query: 1034 HLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT 1093
HLAAA G EV + L+ ID DE G +H AAQ +++ V+ L+ ++ + +
Sbjct: 708 HLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSL 766
Query: 1094 K 1094
K
Sbjct: 767 K 767
Score = 121 bits (292), Expect = 2e-26
Identities = 87/334 (26%), Positives = 155/334 (46%), Gaps = 17/334 (5%)
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK 1195
L LA E G + + L+ A+ NR G T +H+A E V++++ + +
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
Query: 1196 KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNG 1255
+ T LH AA G + R LL K+ + V G TP+H+A +G
Sbjct: 502 EDQWTALHFAAQNGDESSTRLLLE------KNASVNEVDF-------EGRTPMHVACQHG 548
Query: 1256 NENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKT 1315
EN+VR+LL GV + ++ + PLH A + GH+ IV LL + +++ G+T
Sbjct: 549 QENIVRILLRR-GVDV-SLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRT 606
Query: 1316 GLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSE 1375
LH+A+ GHY++ +L+ +++N TPLH AA+ GH + +LL GA ++
Sbjct: 607 PLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAV 666
Query: 1376 TNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVL 1435
T+ + AA H ++ L+ ++ D + + +L + H+ + +EE V
Sbjct: 667 TSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHL-AAAHGHSEV-VEELVS 724
Query: 1436 VSPAPVDTAAKLSNIYINLSTKEKERAKDLIAAG 1469
+ LS +++ + + + L+ G
Sbjct: 725 ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHG 758
Score = 105 bits (251), Expect = 2e-21
Identities = 107/371 (28%), Positives = 173/371 (46%), Gaps = 38/371 (10%)
Query: 687 ESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKC 746
+ VD+ + + LH+AVE+ + + LL A+ ++ ++ TPLH+A
Sbjct: 429 QDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNL-SNRRGSTPLHMAVERRVRGVV 487
Query: 747 ALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGET 806
L+L + N ED T +H AA+ G+ ++ LLLE + V D G T
Sbjct: 488 ELLLARK-ISVNAKDEDQWTALHFAAQNGDESSTRLLLE------KNASVNEVD-FEGRT 539
Query: 807 PLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPT 866
P+ +AC+ +IVR L+ +G VS +D LHYA + +P
Sbjct: 540 PMHVACQHGQENIVRILL-----RRGVDVSLQ-----GKDAWLPLHYAA----WQGHLP- 584
Query: 867 ADRQVVKCLIEN-GADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQ 925
+VK L + G V+ QT + T H A G+ V +I D+ +N
Sbjct: 585 ----IVKLLAKQPGVSVNAQTL-DGRTPLHLAAQRGHYRVARILI------DLCSDVNVC 633
Query: 926 NSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNK 985
+ + TPL +A GH LL A + +G +ALHLAA +G+L L+ K
Sbjct: 634 SLLAQTPLHVAAETGHTSTARLLLHRGAGKEAVTSDGYTALHLAARNGHLATVKLLVEEK 693
Query: 986 AFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVC 1045
A + ++ +TALHLAA +G++ +V+ L+ +ID+ + + LHLAA +
Sbjct: 694 ADVLARGPLNQTALHLAAAHGHSEVVEELVSAD--VIDLFDEQGLSALHLAAQGRHAQTV 751
Query: 1046 KLLLELGANID 1056
+ LL GA+I+
Sbjct: 752 ETLLRHGAHIN 762
Score = 92.3 bits (219), Expect = 2e-17
Identities = 105/368 (28%), Positives = 161/368 (43%), Gaps = 36/368 (9%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
GA +H A G LL + +++ T LH+AVE VVE LL V
Sbjct: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + + + T LH AA+ D + +LL+ A N+ +G TP+HVA + G + +
Sbjct: 498 NAK-DEDQWTALHFAAQNGD-ESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRI 555
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL G D + K PL A IV+ L K VS ++A
Sbjct: 556 LLRRGVDVSLQGK-------DAWLPLHYAAWQGHLPIVKLLA------KQPGVS---VNA 599
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
DG + LH A + +V + LI+ +DV++ + +T H A G+
Sbjct: 600 QTLDGRTPLHLAAQ---------RGHYRVARILIDLCSDVNVCSL-LAQTPLHVAAETGH 649
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
++ H S G+T L +A GH+ V L+ A V
Sbjct: 650 TST-ARLLLHRGAGK-----EAVTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLN 703
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
++ALHLAA HG+ +V + L++ I+ G +ALHLAA +A V+ L+R H A I
Sbjct: 704 QTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLR-HGAHI 761
Query: 1023 DVLTLKKQ 1030
++ +LK Q
Sbjct: 762 NLQSLKFQ 769
Score = 91.9 bits (218), Expect = 2e-17
Identities = 89/299 (29%), Positives = 137/299 (45%), Gaps = 35/299 (11%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K D ++H AA+ G LL+K SV+ + T +H+A + + +V LL
Sbjct: 500 KDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR 559
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
G DV ++ GK PLH AA L+ + G N T DG TP+H+AA+ G+
Sbjct: 560 GVDVSLQ-GKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYR 618
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+L++ D VC + +TPL +A + R L+ H+G A
Sbjct: 619 VARILIDLCSD----VNVC---SLLAQTPLHVAAETGHTSTARLLL-----HRG-----A 661
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
+AV DG +ALH A + VK L+E ADV + N +TA H A
Sbjct: 662 GKEAVTSDGYTALHLAAR---------NGHLATVKLLVEEKADVLARGPLN-QTALHLAA 711
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
G+++V+ E++ +ADV + Q G + L +A H Q V TLL + A +++
Sbjct: 712 AHGHSEVVEELV----SADVIDLFDEQ---GLSALHLAAQGRHAQTVETLLRHGAHINL 763
Score = 87.8 bits (208), Expect = 4e-16
Identities = 51/157 (32%), Positives = 83/157 (52%), Gaps = 2/157 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+RG PL +AVE + +V LL+ + + K TALH AA+ D R+L++
Sbjct: 469 RRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQW--TALHFAAQNGDESSTRLLLEK 526
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A V+ + G+TP+H+A G E +V+ + ++ + P+H AA GH I+
Sbjct: 527 NASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIV 586
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+LLA + S+ +T DG T +H+A+ GH A +L
Sbjct: 587 KLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARIL 623
Score = 87.4 bits (207), Expect = 5e-16
Identities = 52/148 (35%), Positives = 80/148 (54%), Gaps = 2/148 (1%)
Query: 65 VPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVV 124
+PL A G+ +V+ LL+ Q + A T G T LHLAA+R +ARIL+D + V
Sbjct: 572 LPLHYAAWQGHLPIVK-LLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDV 630
Query: 125 DATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
+ + QTPLH+AA G + A ++ T +HLAA NGH A ++LL
Sbjct: 631 NVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAVTSDGYTALHLAARNGHLATVKLLV 690
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHAD 212
++ KA + R T +H+A+ +GH++
Sbjct: 691 EE-KADVLARGPLNQTALHLAAAHGHSE 717
Score = 81.4 bits (192), Expect = 3e-14
Identities = 52/161 (32%), Positives = 79/161 (49%), Gaps = 5/161 (3%)
Query: 1239 LGAESGLTPLHLAAYNGNENVVR-LLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGL 1297
L +SG + LHLA G E + LLLN+A SN G PLH+A +V L
Sbjct: 433 LALDSGASLLHLAVEAGQEECAKWLLLNNANPN---LSNRRGSTPLHMAVERRVRGVVEL 489
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
LL+R +++ D T LH A+ +G +LL + A +N D G TP+H A + G
Sbjct: 490 LLARKIS-VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHG 548
Query: 1358 HLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYL 1398
N+V++L G + P+ +AA + H +++ L
Sbjct: 549 QENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLL 589
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/170 (27%), Positives = 82/170 (48%), Gaps = 4/170 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ PL LA + G+ + R L+ + + T LH+AA AR+L+ GA
Sbjct: 604 GRTPLHLAAQRGHYRVARILIDL--CSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGA 661
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+A G T LH+AA G VK +A+ ++T +HLAA +GH+ ++E
Sbjct: 662 GKEAVTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEE 721
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFE 232
L +F+ + G + +H+A+ HA L + G ++++ + F+
Sbjct: 722 LVSADVIDLFD--EQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQ 769
Score = 72.9 bits (171), Expect = 1e-11
Identities = 51/164 (31%), Positives = 74/164 (45%), Gaps = 3/164 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
DL G L LAVEAG + + LL L + G T LH+A RR + +
Sbjct: 432 DLALDSGASLLHLAVEAGQEECAKWLLLNNANPNL--SNRRGSTPLHMAVERRVRGVVEL 489
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+ V+A + T LH AA GDE + A+ D E RTPMH+A ++G
Sbjct: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
I+ +L + + + KD +H A+ GH +L K+
Sbjct: 550 ENIVRILLRR-GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQ 592
Score = 69.7 bits (163), Expect = 1e-10
Identities = 46/166 (27%), Positives = 81/166 (48%), Gaps = 4/166 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
K L+ A+ +G+ S + ++L Q + +G + LHLA + A+ L+ A
Sbjct: 407 KKKLVDAIVSGDTSKLMKILQPQDVD---LALDSGASLLHLAVEAGQEECAKWLLLNNAN 463
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
+ +N G TPLH+A +V+ + + D + T +H AA+NG + LL
Sbjct: 464 PNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLL 523
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+K AS+ E +G T MH+A +G + +L ++GV + + K
Sbjct: 524 LEK-NASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGK 568
Score = 59.3 bits (137), Expect = 1e-07
Identities = 39/128 (30%), Positives = 61/128 (47%), Gaps = 1/128 (0%)
Query: 1277 ENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG 1336
++G + LHLA G LL +A + ++R G T LH+A +VE+LL +
Sbjct: 436 DSGASLLHLAVEAGQEECAKWLLLNNANP-NLSNRRGSTPLHMAVERRVRGVVELLLARK 494
Query: 1337 AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLE 1396
+NA D++ WT LH AA+ G + +LL E AS P+ A +++
Sbjct: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554
Query: 1397 YLLHKEHD 1404
LL + D
Sbjct: 555 ILLRRGVD 562
>AP001743-1|BAA95526.1| 832|Homo sapiens ANKRD3 protein.
Length = 832
Score = 152 bits (369), Expect = 1e-35
Identities = 113/377 (29%), Positives = 182/377 (48%), Gaps = 23/377 (6%)
Query: 907 TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSAL 966
++++ + DV AL+ S+ L +A G + LL N+A ++ + G + L
Sbjct: 468 SKLMKILQPQDVDLALDSGASL----LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL 523
Query: 967 HLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
H+A E V + LL K +N+K + TALH AA NG + L+ + NA ++ +
Sbjct: 524 HMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLL-EKNASVNEVD 582
Query: 1027 LKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP 1086
+ +TP+H+A GQ + ++LL G ++ + P+H AA + +V+L +Q
Sbjct: 583 FEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPG 642
Query: 1087 NLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHAD 1146
V A T DG T H+AA +G +V L+ D ++ + L TPL +AAE GH
Sbjct: 643 VSVNAQTLDGRTPLHLAAQRGHYRVARILI--DLCSDVNVCSLLAQ-TPLHVAAETGHTS 699
Query: 1147 VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
R+L+ GA G TA+HLAA +GH + ++ ++ L T LH+AA
Sbjct: 700 TARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAA 759
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLL-N 1265
+G +E V EL+S + V L E GL+ LHLAA + V LL +
Sbjct: 760 AHGHSEVVEELVS--------------ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRH 805
Query: 1266 SAGVQADAASNENGYNP 1282
A + + + G+ P
Sbjct: 806 GAHINLQSLKFQGGHGP 822
Score = 148 bits (359), Expect = 2e-34
Identities = 105/346 (30%), Positives = 168/346 (48%), Gaps = 23/346 (6%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+D + GAS LH A + +EE K L+ N A+ +L R T H
Sbjct: 479 VDLALDSGASLLHLAVEAGQEEC---------AKWLLLNNANPNLSNRRG-STPLHMAVE 528
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
V+ ++A ++N ++ WT L A G LL +A V+ D
Sbjct: 529 RRVRGVVELLLAR------KISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 582
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
EGR+ +H+A +HG + LL ++ + ++ LH AA G+ +VK L +
Sbjct: 583 FEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPG 642
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
++ TL +TPLHLAA G V ++L++L ++++ L Q P+H AA+ ++ +
Sbjct: 643 VSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTAR 702
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLA 1139
L L + A T DG T H+AA G + ++ L++ ++ V+ AR LN T L LA
Sbjct: 703 LLLHRGAG-KEAMTSDGYTALHLAARNGHLATVKLLVE-EKADVL-ARGPLN-QTALHLA 758
Query: 1140 AEGGHADVVRVLVRAGA-SCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
A GH++VV LV A DE GL+A+HLAA+ H ++ +
Sbjct: 759 AAHGHSEVVEELVSADVIDLFDEQ--GLSALHLAAQGRHAQTVETL 802
Score = 137 bits (331), Expect = 5e-31
Identities = 115/349 (32%), Positives = 164/349 (46%), Gaps = 25/349 (7%)
Query: 994 NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA 1053
+G + LHLA G K+L+ + NA ++ + TPLH+A V +LLL
Sbjct: 485 SGASLLHLAVEAGQEECAKWLLLN-NANPNLSNRRGSTPLHMAVERRVRGVVELLLARKI 543
Query: 1054 NIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIE 1113
+++A DE +H AAQN +L L+++ + V +G T H+A G ++
Sbjct: 544 SVNAKDEDQWTALHFAAQNGDESSTRLLLEKNAS-VNEVDFEGRTPMHVACQHGQENIVR 602
Query: 1114 ELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLA 1172
L+ R GV + + PL AA GH +V++L + G S + G T +HLA
Sbjct: 603 ILL---RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLA 659
Query: 1173 AEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
A+ GH V ++ + L TPLH+AA G T R LL G EA T
Sbjct: 660 AQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAG---KEAMTS 716
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS-AGVQADAASNENGYNPLHLACFGGH 1291
G T LHLAA NG+ V+LL+ A V A N+ LHLA GH
Sbjct: 717 ----------DGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTA---LHLAAAHGH 763
Query: 1292 MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN 1340
+V L+S A+++ D G + LH+A+ H Q VE LL GA IN
Sbjct: 764 SEVVEELVS--ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 810
Score = 123 bits (296), Expect = 8e-27
Identities = 111/361 (30%), Positives = 172/361 (47%), Gaps = 35/361 (9%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
LH+A ++CA LL + A PN + G TP+H+A + + LLL RK
Sbjct: 490 LHLAVEAGQ-EECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLL------ARK 542
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHY 853
V D T L A ++ R L+E A ++ VD +G + +H
Sbjct: 543 ISVNAKD-EDQWTALHFAAQNGDESSTRLLLE----------KNASVNEVDFEGRTPMHV 591
Query: 854 ACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHI 913
AC+ +E +V+ L+ G DVSLQ + + HY A G+ ++ +++A
Sbjct: 592 ACQHGQE---------NIVRILLRRGVDVSLQGK-DAWLPLHYAAWQGHLPIV-KLLA-- 638
Query: 914 STADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHG 973
VS +N Q G TPL +A RGH ++ L+ + V+V + ++ LH+AAE G
Sbjct: 639 KQPGVS--VNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETG 696
Query: 974 YLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPL 1033
+ LL A + +G TALHLAA NG+ VK L+ + ++ L QT L
Sbjct: 697 HTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPL-NQTAL 755
Query: 1034 HLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT 1093
HLAAA G EV + L+ ID DE G +H AAQ +++ V+ L+ ++ + +
Sbjct: 756 HLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSL 814
Query: 1094 K 1094
K
Sbjct: 815 K 815
Score = 121 bits (292), Expect = 2e-26
Identities = 87/334 (26%), Positives = 155/334 (46%), Gaps = 17/334 (5%)
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK 1195
L LA E G + + L+ A+ NR G T +H+A E V++++ + +
Sbjct: 490 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 549
Query: 1196 KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNG 1255
+ T LH AA G + R LL K+ + V G TP+H+A +G
Sbjct: 550 EDQWTALHFAAQNGDESSTRLLLE------KNASVNEVDF-------EGRTPMHVACQHG 596
Query: 1256 NENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKT 1315
EN+VR+LL GV + ++ + PLH A + GH+ IV LL + +++ G+T
Sbjct: 597 QENIVRILLRR-GVDV-SLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRT 654
Query: 1316 GLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSE 1375
LH+A+ GHY++ +L+ +++N TPLH AA+ GH + +LL GA ++
Sbjct: 655 PLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAM 714
Query: 1376 TNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVL 1435
T+ + AA H ++ L+ ++ D + + +L + H+ + +EE V
Sbjct: 715 TSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHL-AAAHGHSEV-VEELVS 772
Query: 1436 VSPAPVDTAAKLSNIYINLSTKEKERAKDLIAAG 1469
+ LS +++ + + + L+ G
Sbjct: 773 ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHG 806
Score = 105 bits (252), Expect = 2e-21
Identities = 107/371 (28%), Positives = 173/371 (46%), Gaps = 38/371 (10%)
Query: 687 ESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKC 746
+ VD+ + + LH+AVE+ + + LL A+ ++ ++ TPLH+A
Sbjct: 477 QDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNL-SNRRGSTPLHMAVERRVRGVV 535
Query: 747 ALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGET 806
L+L + N ED T +H AA+ G+ ++ LLLE + V D G T
Sbjct: 536 ELLLARK-ISVNAKDEDQWTALHFAAQNGDESSTRLLLE------KNASVNEVD-FEGRT 587
Query: 807 PLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPT 866
P+ +AC+ +IVR L+ +G VS +D LHYA + +P
Sbjct: 588 PMHVACQHGQENIVRILL-----RRGVDVSLQ-----GKDAWLPLHYAA----WQGHLP- 632
Query: 867 ADRQVVKCLIEN-GADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQ 925
+VK L + G V+ QT + T H A G+ V +I D+ +N
Sbjct: 633 ----IVKLLAKQPGVSVNAQTL-DGRTPLHLAAQRGHYRVARILI------DLCSDVNVC 681
Query: 926 NSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNK 985
+ + TPL +A GH LL A + +G +ALHLAA +G+L L+ K
Sbjct: 682 SLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEK 741
Query: 986 AFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVC 1045
A + ++ +TALHLAA +G++ +V+ L+ +ID+ + + LHLAA +
Sbjct: 742 ADVLARGPLNQTALHLAAAHGHSEVVEELVSAD--VIDLFDEQGLSALHLAAQGRHAQTV 799
Query: 1046 KLLLELGANID 1056
+ LL GA+I+
Sbjct: 800 ETLLRHGAHIN 810
Score = 93.1 bits (221), Expect = 1e-17
Identities = 105/368 (28%), Positives = 161/368 (43%), Gaps = 36/368 (9%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
GA +H A G LL + +++ T LH+AVE VVE LL V
Sbjct: 486 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 545
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + + + T LH AA+ D + +LL+ A N+ +G TP+HVA + G + +
Sbjct: 546 NAK-DEDQWTALHFAAQNGD-ESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRI 603
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL G D + K PL A IV+ L K VS ++A
Sbjct: 604 LLRRGVDVSLQGK-------DAWLPLHYAAWQGHLPIVKLLA------KQPGVS---VNA 647
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
DG + LH A + +V + LI+ +DV++ + +T H A G+
Sbjct: 648 QTLDGRTPLHLAAQ---------RGHYRVARILIDLCSDVNVCSL-LAQTPLHVAAETGH 697
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
++ H S G+T L +A GH+ V L+ A V
Sbjct: 698 TST-ARLLLHRGAGK-----EAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLN 751
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
++ALHLAA HG+ +V + L++ I+ G +ALHLAA +A V+ L+R H A I
Sbjct: 752 QTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLR-HGAHI 809
Query: 1023 DVLTLKKQ 1030
++ +LK Q
Sbjct: 810 NLQSLKFQ 817
Score = 90.6 bits (215), Expect = 5e-17
Identities = 88/299 (29%), Positives = 137/299 (45%), Gaps = 35/299 (11%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K D ++H AA+ G LL+K SV+ + T +H+A + + +V LL
Sbjct: 548 KDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR 607
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
G DV ++ GK PLH AA L+ + G N T DG TP+H+AA+ G+
Sbjct: 608 GVDVSLQ-GKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYR 666
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+L++ D VC + +TPL +A + R L+ H+G A
Sbjct: 667 VARILIDLCSD----VNVC---SLLAQTPLHVAAETGHTSTARLLL-----HRG-----A 709
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
+A+ DG +ALH A + VK L+E ADV + N +TA H A
Sbjct: 710 GKEAMTSDGYTALHLAAR---------NGHLATVKLLVEEKADVLARGPLN-QTALHLAA 759
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
G+++V+ E++ +ADV + Q G + L +A H Q V TLL + A +++
Sbjct: 760 AHGHSEVVEELV----SADVIDLFDEQ---GLSALHLAAQGRHAQTVETLLRHGAHINL 811
Score = 87.8 bits (208), Expect = 4e-16
Identities = 51/157 (32%), Positives = 83/157 (52%), Gaps = 2/157 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+RG PL +AVE + +V LL+ + + K TALH AA+ D R+L++
Sbjct: 517 RRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQW--TALHFAAQNGDESSTRLLLEK 574
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A V+ + G+TP+H+A G E +V+ + ++ + P+H AA GH I+
Sbjct: 575 NASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIV 634
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+LLA + S+ +T DG T +H+A+ GH A +L
Sbjct: 635 KLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARIL 671
Score = 87.0 bits (206), Expect = 6e-16
Identities = 52/148 (35%), Positives = 80/148 (54%), Gaps = 2/148 (1%)
Query: 65 VPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVV 124
+PL A G+ +V+ LL+ Q + A T G T LHLAA+R +ARIL+D + V
Sbjct: 620 LPLHYAAWQGHLPIVK-LLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDV 678
Query: 125 DATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
+ + QTPLH+AA G + A ++ T +HLAA NGH A ++LL
Sbjct: 679 NVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLV 738
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHAD 212
++ KA + R T +H+A+ +GH++
Sbjct: 739 EE-KADVLARGPLNQTALHLAAAHGHSE 765
Score = 81.4 bits (192), Expect = 3e-14
Identities = 52/161 (32%), Positives = 79/161 (49%), Gaps = 5/161 (3%)
Query: 1239 LGAESGLTPLHLAAYNGNENVVR-LLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGL 1297
L +SG + LHLA G E + LLLN+A SN G PLH+A +V L
Sbjct: 481 LALDSGASLLHLAVEAGQEECAKWLLLNNANPN---LSNRRGSTPLHMAVERRVRGVVEL 537
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
LL+R +++ D T LH A+ +G +LL + A +N D G TP+H A + G
Sbjct: 538 LLARKIS-VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHG 596
Query: 1358 HLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYL 1398
N+V++L G + P+ +AA + H +++ L
Sbjct: 597 QENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLL 637
Score = 79.0 bits (186), Expect = 2e-13
Identities = 47/170 (27%), Positives = 82/170 (48%), Gaps = 4/170 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ PL LA + G+ + R L+ + + T LH+AA AR+L+ GA
Sbjct: 652 GRTPLHLAAQRGHYRVARILIDL--CSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGA 709
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+A G T LH+AA G VK +A+ ++T +HLAA +GH+ ++E
Sbjct: 710 GKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEE 769
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFE 232
L +F+ + G + +H+A+ HA L + G ++++ + F+
Sbjct: 770 LVSADVIDLFD--EQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQ 817
Score = 72.9 bits (171), Expect = 1e-11
Identities = 51/164 (31%), Positives = 74/164 (45%), Gaps = 3/164 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
DL G L LAVEAG + + LL L + G T LH+A RR + +
Sbjct: 480 DLALDSGASLLHLAVEAGQEECAKWLLLNNANPNL--SNRRGSTPLHMAVERRVRGVVEL 537
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+ V+A + T LH AA GDE + A+ D E RTPMH+A ++G
Sbjct: 538 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 597
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
I+ +L + + + KD +H A+ GH +L K+
Sbjct: 598 ENIVRILLRR-GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQ 640
Score = 69.7 bits (163), Expect = 1e-10
Identities = 46/166 (27%), Positives = 81/166 (48%), Gaps = 4/166 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
K L+ A+ +G+ S + ++L Q + +G + LHLA + A+ L+ A
Sbjct: 455 KKKLVDAIVSGDTSKLMKILQPQDVD---LALDSGASLLHLAVEAGQEECAKWLLLNNAN 511
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
+ +N G TPLH+A +V+ + + D + T +H AA+NG + LL
Sbjct: 512 PNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLL 571
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+K AS+ E +G T MH+A +G + +L ++GV + + K
Sbjct: 572 LEK-NASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGK 616
Score = 59.3 bits (137), Expect = 1e-07
Identities = 39/128 (30%), Positives = 61/128 (47%), Gaps = 1/128 (0%)
Query: 1277 ENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG 1336
++G + LHLA G LL +A + ++R G T LH+A +VE+LL +
Sbjct: 484 DSGASLLHLAVEAGQEECAKWLLLNNANP-NLSNRRGSTPLHMAVERRVRGVVELLLARK 542
Query: 1337 AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLE 1396
+NA D++ WT LH AA+ G + +LL E AS P+ A +++
Sbjct: 543 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 602
Query: 1397 YLLHKEHD 1404
LL + D
Sbjct: 603 ILLRRGVD 610
>AJ278016-1|CAC04247.1| 784|Homo sapiens protein kinase protein.
Length = 784
Score = 152 bits (369), Expect = 1e-35
Identities = 113/377 (29%), Positives = 182/377 (48%), Gaps = 23/377 (6%)
Query: 907 TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSAL 966
++++ + DV AL+ S+ L +A G + LL N+A ++ + G + L
Sbjct: 420 SKLMKILQPQDVDLALDSGASL----LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL 475
Query: 967 HLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
H+A E V + LL K +N+K + TALH AA NG + L+ + NA ++ +
Sbjct: 476 HMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLL-EKNASVNEVD 534
Query: 1027 LKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP 1086
+ +TP+H+A GQ + ++LL G ++ + P+H AA + +V+L +Q
Sbjct: 535 FEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPG 594
Query: 1087 NLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHAD 1146
V A T DG T H+AA +G +V L+ D ++ + L TPL +AAE GH
Sbjct: 595 VSVNAQTLDGRTPLHLAAQRGHYRVARILI--DLCSDVNVCSLLAQ-TPLHVAAETGHTS 651
Query: 1147 VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
R+L+ GA G TA+HLAA +GH + ++ ++ L T LH+AA
Sbjct: 652 TARLLLHRGAGKKAVTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAA 711
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLL-N 1265
+G +E V EL+S + V L E GL+ LHLAA + V LL +
Sbjct: 712 AHGHSEVVEELVS--------------ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRH 757
Query: 1266 SAGVQADAASNENGYNP 1282
A + + + G+ P
Sbjct: 758 GAHINLQSLKFQGGHGP 774
Score = 149 bits (361), Expect = 1e-34
Identities = 105/346 (30%), Positives = 168/346 (48%), Gaps = 23/346 (6%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+D + GAS LH A + +EE K L+ N A+ +L R T H
Sbjct: 431 VDLALDSGASLLHLAVEAGQEEC---------AKWLLLNNANPNLSNRRG-STPLHMAVE 480
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
V+ ++A ++N ++ WT L A G LL +A V+ D
Sbjct: 481 RRVRGVVELLLAR------KISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
EGR+ +H+A +HG + LL ++ + ++ LH AA G+ +VK L +
Sbjct: 535 FEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPG 594
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
++ TL +TPLHLAA G V ++L++L ++++ L Q P+H AA+ ++ +
Sbjct: 595 VSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTAR 654
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLA 1139
L L + A T DG T H+AA G + ++ L++ ++ V+ AR LN T L LA
Sbjct: 655 LLLHRGAG-KKAVTSDGYTALHLAARNGHLATVKLLVE-EKADVL-ARGPLN-QTALHLA 710
Query: 1140 AEGGHADVVRVLVRAGA-SCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
A GH++VV LV A DE GL+A+HLAA+ H ++ +
Sbjct: 711 AAHGHSEVVEELVSADVIDLFDEQ--GLSALHLAAQGRHAQTVETL 754
Score = 135 bits (327), Expect = 1e-30
Identities = 114/349 (32%), Positives = 164/349 (46%), Gaps = 25/349 (7%)
Query: 994 NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA 1053
+G + LHLA G K+L+ + NA ++ + TPLH+A V +LLL
Sbjct: 437 SGASLLHLAVEAGQEECAKWLLLN-NANPNLSNRRGSTPLHMAVERRVRGVVELLLARKI 495
Query: 1054 NIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIE 1113
+++A DE +H AAQN +L L+++ + V +G T H+A G ++
Sbjct: 496 SVNAKDEDQWTALHFAAQNGDESSTRLLLEKNAS-VNEVDFEGRTPMHVACQHGQENIVR 554
Query: 1114 ELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLA 1172
L+ R GV + + PL AA GH +V++L + G S + G T +HLA
Sbjct: 555 ILL---RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLA 611
Query: 1173 AEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
A+ GH V ++ + L TPLH+AA G T R LL G +A T
Sbjct: 612 AQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAG---KKAVTS 668
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS-AGVQADAASNENGYNPLHLACFGGH 1291
G T LHLAA NG+ V+LL+ A V A N+ LHLA GH
Sbjct: 669 ----------DGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTA---LHLAAAHGH 715
Query: 1292 MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN 1340
+V L+S A+++ D G + LH+A+ H Q VE LL GA IN
Sbjct: 716 SEVVEELVS--ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
Score = 123 bits (296), Expect = 8e-27
Identities = 88/334 (26%), Positives = 155/334 (46%), Gaps = 17/334 (5%)
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK 1195
L LA E G + + L+ A+ NR G T +H+A E V++++ + +
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
Query: 1196 KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNG 1255
+ T LH AA G + R LL K+ + V G TP+H+A +G
Sbjct: 502 EDQWTALHFAAQNGDESSTRLLLE------KNASVNEVDF-------EGRTPMHVACQHG 548
Query: 1256 NENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKT 1315
EN+VR+LL GV + ++ + PLH A + GH+ IV LL + +++ G+T
Sbjct: 549 QENIVRILLRR-GVDV-SLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRT 606
Query: 1316 GLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSE 1375
LH+A+ GHY++ +L+ +++N TPLH AA+ GH + +LL GA K+
Sbjct: 607 PLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKKAV 666
Query: 1376 TNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVL 1435
T+ + AA H ++ L+ ++ D + + +L + H+ + +EE V
Sbjct: 667 TSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHL-AAAHGHSEV-VEELVS 724
Query: 1436 VSPAPVDTAAKLSNIYINLSTKEKERAKDLIAAG 1469
+ LS +++ + + + L+ G
Sbjct: 725 ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHG 758
Score = 122 bits (295), Expect = 1e-26
Identities = 111/361 (30%), Positives = 172/361 (47%), Gaps = 35/361 (9%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
LH+A ++CA LL + A PN + G TP+H+A + + LLL RK
Sbjct: 442 LHLAVEAGQ-EECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLL------ARK 494
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHY 853
V D T L A ++ R L+E A ++ VD +G + +H
Sbjct: 495 ISVNAKD-EDQWTALHFAAQNGDESSTRLLLE----------KNASVNEVDFEGRTPMHV 543
Query: 854 ACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHI 913
AC+ +E +V+ L+ G DVSLQ + + HY A G+ ++ +++A
Sbjct: 544 ACQHGQE---------NIVRILLRRGVDVSLQGK-DAWLPLHYAAWQGHLPIV-KLLA-- 590
Query: 914 STADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHG 973
VS +N Q G TPL +A RGH ++ L+ + V+V + ++ LH+AAE G
Sbjct: 591 KQPGVS--VNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETG 648
Query: 974 YLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPL 1033
+ LL A + +G TALHLAA NG+ VK L+ + ++ L QT L
Sbjct: 649 HTSTARLLLHRGAGKKAVTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPL-NQTAL 707
Query: 1034 HLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT 1093
HLAAA G EV + L+ ID DE G +H AAQ +++ V+ L+ ++ + +
Sbjct: 708 HLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSL 766
Query: 1094 K 1094
K
Sbjct: 767 K 767
Score = 103 bits (248), Expect = 5e-21
Identities = 107/371 (28%), Positives = 172/371 (46%), Gaps = 38/371 (10%)
Query: 687 ESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKC 746
+ VD+ + + LH+AVE+ + + LL A+ ++ ++ TPLH+A
Sbjct: 429 QDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNL-SNRRGSTPLHMAVERRVRGVV 487
Query: 747 ALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGET 806
L+L + N ED T +H AA+ G+ ++ LLLE + V D G T
Sbjct: 488 ELLLARK-ISVNAKDEDQWTALHFAAQNGDESSTRLLLE------KNASVNEVD-FEGRT 539
Query: 807 PLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPT 866
P+ +AC+ +IVR L+ +G VS +D LHYA + +P
Sbjct: 540 PMHVACQHGQENIVRILL-----RRGVDVSLQ-----GKDAWLPLHYAA----WQGHLP- 584
Query: 867 ADRQVVKCLIEN-GADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQ 925
+VK L + G V+ QT + T H A G+ V +I D+ +N
Sbjct: 585 ----IVKLLAKQPGVSVNAQTL-DGRTPLHLAAQRGHYRVARILI------DLCSDVNVC 633
Query: 926 NSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNK 985
+ + TPL +A GH LL A +G +ALHLAA +G+L L+ K
Sbjct: 634 SLLAQTPLHVAAETGHTSTARLLLHRGAGKKAVTSDGYTALHLAARNGHLATVKLLVEEK 693
Query: 986 AFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVC 1045
A + ++ +TALHLAA +G++ +V+ L+ +ID+ + + LHLAA +
Sbjct: 694 ADVLARGPLNQTALHLAAAHGHSEVVEELVSAD--VIDLFDEQGLSALHLAAQGRHAQTV 751
Query: 1046 KLLLELGANID 1056
+ LL GA+I+
Sbjct: 752 ETLLRHGAHIN 762
Score = 93.1 bits (221), Expect = 1e-17
Identities = 106/368 (28%), Positives = 164/368 (44%), Gaps = 36/368 (9%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
GA +H A G LL + +++ T LH+AVE VVE LL V
Sbjct: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + + + T LH AA+ D + +LL+ A N+ +G TP+HVA + G + +
Sbjct: 498 NAK-DEDQWTALHFAAQNGD-ESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRI 555
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL G D + K PL A IV+ L K VS ++A
Sbjct: 556 LLRRGVDVSLQGK-------DAWLPLHYAAWQGHLPIVKLLA------KQPGVS---VNA 599
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
DG + LH A + +V + LI+ +DV++ + +T H A G+
Sbjct: 600 QTLDGRTPLHLAAQ---------RGHYRVARILIDLCSDVNVCSL-LAQTPLHVAAETGH 649
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
++ H +A+ S G+T L +A GH+ V L+ A V
Sbjct: 650 TST-ARLLLHRGAG--KKAV---TSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLN 703
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
++ALHLAA HG+ +V + L++ I+ G +ALHLAA +A V+ L+R H A I
Sbjct: 704 QTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLR-HGAHI 761
Query: 1023 DVLTLKKQ 1030
++ +LK Q
Sbjct: 762 NLQSLKFQ 769
Score = 90.6 bits (215), Expect = 5e-17
Identities = 89/299 (29%), Positives = 136/299 (45%), Gaps = 35/299 (11%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K D ++H AA+ G LL+K SV+ + T +H+A + + +V LL
Sbjct: 500 KDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR 559
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
G DV ++ GK PLH AA L+ + G N T DG TP+H+AA+ G+
Sbjct: 560 GVDVSLQ-GKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYR 618
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+L++ D VC + +TPL +A + R L+ H+G A
Sbjct: 619 VARILIDLCSD----VNVC---SLLAQTPLHVAAETGHTSTARLLL-----HRG-----A 661
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
AV DG +ALH A + VK L+E ADV + N +TA H A
Sbjct: 662 GKKAVTSDGYTALHLAAR---------NGHLATVKLLVEEKADVLARGPLN-QTALHLAA 711
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
G+++V+ E++ +ADV + Q G + L +A H Q V TLL + A +++
Sbjct: 712 AHGHSEVVEELV----SADVIDLFDEQ---GLSALHLAAQGRHAQTVETLLRHGAHINL 763
Score = 87.8 bits (208), Expect = 4e-16
Identities = 51/157 (32%), Positives = 83/157 (52%), Gaps = 2/157 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+RG PL +AVE + +V LL+ + + K TALH AA+ D R+L++
Sbjct: 469 RRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQW--TALHFAAQNGDESSTRLLLEK 526
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A V+ + G+TP+H+A G E +V+ + ++ + P+H AA GH I+
Sbjct: 527 NASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIV 586
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+LLA + S+ +T DG T +H+A+ GH A +L
Sbjct: 587 KLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARIL 623
Score = 87.4 bits (207), Expect = 5e-16
Identities = 52/148 (35%), Positives = 80/148 (54%), Gaps = 2/148 (1%)
Query: 65 VPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVV 124
+PL A G+ +V+ LL+ Q + A T G T LHLAA+R +ARIL+D + V
Sbjct: 572 LPLHYAAWQGHLPIVK-LLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDV 630
Query: 125 DATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
+ + QTPLH+AA G + A ++ T +HLAA NGH A ++LL
Sbjct: 631 NVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKKAVTSDGYTALHLAARNGHLATVKLLV 690
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHAD 212
++ KA + R T +H+A+ +GH++
Sbjct: 691 EE-KADVLARGPLNQTALHLAAAHGHSE 717
Score = 81.4 bits (192), Expect = 3e-14
Identities = 52/161 (32%), Positives = 79/161 (49%), Gaps = 5/161 (3%)
Query: 1239 LGAESGLTPLHLAAYNGNENVVR-LLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGL 1297
L +SG + LHLA G E + LLLN+A SN G PLH+A +V L
Sbjct: 433 LALDSGASLLHLAVEAGQEECAKWLLLNNANPN---LSNRRGSTPLHMAVERRVRGVVEL 489
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
LL+R +++ D T LH A+ +G +LL + A +N D G TP+H A + G
Sbjct: 490 LLARKIS-VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHG 548
Query: 1358 HLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYL 1398
N+V++L G + P+ +AA + H +++ L
Sbjct: 549 QENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLL 589
Score = 78.2 bits (184), Expect = 3e-13
Identities = 47/170 (27%), Positives = 81/170 (47%), Gaps = 4/170 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ PL LA + G+ + R L+ + + T LH+AA AR+L+ GA
Sbjct: 604 GRTPLHLAAQRGHYRVARILIDL--CSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGA 661
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
A G T LH+AA G VK +A+ ++T +HLAA +GH+ ++E
Sbjct: 662 GKKAVTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEE 721
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFE 232
L +F+ + G + +H+A+ HA L + G ++++ + F+
Sbjct: 722 LVSADVIDLFD--EQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQ 769
Score = 72.9 bits (171), Expect = 1e-11
Identities = 51/164 (31%), Positives = 74/164 (45%), Gaps = 3/164 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
DL G L LAVEAG + + LL L + G T LH+A RR + +
Sbjct: 432 DLALDSGASLLHLAVEAGQEECAKWLLLNNANPNL--SNRRGSTPLHMAVERRVRGVVEL 489
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+ V+A + T LH AA GDE + A+ D E RTPMH+A ++G
Sbjct: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
I+ +L + + + KD +H A+ GH +L K+
Sbjct: 550 ENIVRILLRR-GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQ 592
Score = 69.7 bits (163), Expect = 1e-10
Identities = 46/166 (27%), Positives = 81/166 (48%), Gaps = 4/166 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
K L+ A+ +G+ S + ++L Q + +G + LHLA + A+ L+ A
Sbjct: 407 KKKLVDAIVSGDTSKLMKILQPQDVD---LALDSGASLLHLAVEAGQEECAKWLLLNNAN 463
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
+ +N G TPLH+A +V+ + + D + T +H AA+NG + LL
Sbjct: 464 PNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLL 523
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+K AS+ E +G T MH+A +G + +L ++GV + + K
Sbjct: 524 LEK-NASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGK 568
Score = 59.3 bits (137), Expect = 1e-07
Identities = 39/128 (30%), Positives = 61/128 (47%), Gaps = 1/128 (0%)
Query: 1277 ENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG 1336
++G + LHLA G LL +A + ++R G T LH+A +VE+LL +
Sbjct: 436 DSGASLLHLAVEAGQEECAKWLLLNNANP-NLSNRRGSTPLHMAVERRVRGVVELLLARK 494
Query: 1337 AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLE 1396
+NA D++ WT LH AA+ G + +LL E AS P+ A +++
Sbjct: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554
Query: 1397 YLLHKEHD 1404
LL + D
Sbjct: 555 ILLRRGVD 562
>AB047783-1|BAB56136.1| 784|Homo sapiens probable dual-specificity
Ser/Thr/Tyr kinase protein.
Length = 784
Score = 152 bits (369), Expect = 1e-35
Identities = 113/377 (29%), Positives = 182/377 (48%), Gaps = 23/377 (6%)
Query: 907 TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSAL 966
++++ + DV AL+ S+ L +A G + LL N+A ++ + G + L
Sbjct: 420 SKLMKILQPQDVDLALDSGASL----LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL 475
Query: 967 HLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
H+A E V + LL K +N+K + TALH AA NG + L+ + NA ++ +
Sbjct: 476 HMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLL-EKNASVNEVD 534
Query: 1027 LKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP 1086
+ +TP+H+A GQ + ++LL G ++ + P+H AA + +V+L +Q
Sbjct: 535 FEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPG 594
Query: 1087 NLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHAD 1146
V A T DG T H+AA +G +V L+ D ++ + L TPL +AAE GH
Sbjct: 595 VSVNAQTLDGRTPLHLAAQRGHYRVARILI--DLCSDVNVCSLLAQ-TPLHVAAETGHTS 651
Query: 1147 VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
R+L+ GA G TA+HLAA +GH + ++ ++ L T LH+AA
Sbjct: 652 TARLLLHRGAGKEAVTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAA 711
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLL-N 1265
+G +E V EL+S + V L E GL+ LHLAA + V LL +
Sbjct: 712 AHGHSEVVEELVS--------------ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRH 757
Query: 1266 SAGVQADAASNENGYNP 1282
A + + + G+ P
Sbjct: 758 GAHINLQSLKFQGGHGP 774
Score = 149 bits (360), Expect = 1e-34
Identities = 105/346 (30%), Positives = 168/346 (48%), Gaps = 23/346 (6%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+D + GAS LH A + +EE K L+ N A+ +L R T H
Sbjct: 431 VDLALDSGASLLHLAVEAGQEEC---------AKWLLLNNANPNLSNRRG-STPLHMAVE 480
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
V+ ++A ++N ++ WT L A G LL +A V+ D
Sbjct: 481 RRVRGVVELLLAR------KISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
EGR+ +H+A +HG + LL ++ + ++ LH AA G+ +VK L +
Sbjct: 535 FEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPG 594
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
++ TL +TPLHLAA G V ++L++L ++++ L Q P+H AA+ ++ +
Sbjct: 595 VSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTAR 654
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLA 1139
L L + A T DG T H+AA G + ++ L++ ++ V+ AR LN T L LA
Sbjct: 655 LLLHRGAG-KEAVTSDGYTALHLAARNGHLATVKLLVE-EKADVL-ARGPLN-QTALHLA 710
Query: 1140 AEGGHADVVRVLVRAGA-SCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
A GH++VV LV A DE GL+A+HLAA+ H ++ +
Sbjct: 711 AAHGHSEVVEELVSADVIDLFDEQ--GLSALHLAAQGRHAQTVETL 754
Score = 137 bits (331), Expect = 5e-31
Identities = 115/349 (32%), Positives = 164/349 (46%), Gaps = 25/349 (7%)
Query: 994 NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA 1053
+G + LHLA G K+L+ + NA ++ + TPLH+A V +LLL
Sbjct: 437 SGASLLHLAVEAGQEECAKWLLLN-NANPNLSNRRGSTPLHMAVERRVRGVVELLLARKI 495
Query: 1054 NIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIE 1113
+++A DE +H AAQN +L L+++ + V +G T H+A G ++
Sbjct: 496 SVNAKDEDQWTALHFAAQNGDESSTRLLLEKNAS-VNEVDFEGRTPMHVACQHGQENIVR 554
Query: 1114 ELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLA 1172
L+ R GV + + PL AA GH +V++L + G S + G T +HLA
Sbjct: 555 ILL---RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLA 611
Query: 1173 AEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
A+ GH V ++ + L TPLH+AA G T R LL G EA T
Sbjct: 612 AQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAG---KEAVTS 668
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS-AGVQADAASNENGYNPLHLACFGGH 1291
G T LHLAA NG+ V+LL+ A V A N+ LHLA GH
Sbjct: 669 ----------DGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTA---LHLAAAHGH 715
Query: 1292 MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN 1340
+V L+S A+++ D G + LH+A+ H Q VE LL GA IN
Sbjct: 716 SEVVEELVS--ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
Score = 122 bits (295), Expect = 1e-26
Identities = 111/361 (30%), Positives = 172/361 (47%), Gaps = 35/361 (9%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
LH+A ++CA LL + A PN + G TP+H+A + + LLL RK
Sbjct: 442 LHLAVEAGQ-EECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLL------ARK 494
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHY 853
V D T L A ++ R L+E A ++ VD +G + +H
Sbjct: 495 ISVNAKD-EDQWTALHFAAQNGDESSTRLLLE----------KNASVNEVDFEGRTPMHV 543
Query: 854 ACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHI 913
AC+ +E +V+ L+ G DVSLQ + + HY A G+ ++ +++A
Sbjct: 544 ACQHGQE---------NIVRILLRRGVDVSLQGK-DAWLPLHYAAWQGHLPIV-KLLA-- 590
Query: 914 STADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHG 973
VS +N Q G TPL +A RGH ++ L+ + V+V + ++ LH+AAE G
Sbjct: 591 KQPGVS--VNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETG 648
Query: 974 YLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPL 1033
+ LL A + +G TALHLAA NG+ VK L+ + ++ L QT L
Sbjct: 649 HTSTARLLLHRGAGKEAVTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPL-NQTAL 707
Query: 1034 HLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT 1093
HLAAA G EV + L+ ID DE G +H AAQ +++ V+ L+ ++ + +
Sbjct: 708 HLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSL 766
Query: 1094 K 1094
K
Sbjct: 767 K 767
Score = 121 bits (292), Expect = 2e-26
Identities = 87/334 (26%), Positives = 155/334 (46%), Gaps = 17/334 (5%)
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK 1195
L LA E G + + L+ A+ NR G T +H+A E V++++ + +
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 501
Query: 1196 KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNG 1255
+ T LH AA G + R LL K+ + V G TP+H+A +G
Sbjct: 502 EDQWTALHFAAQNGDESSTRLLLE------KNASVNEVDF-------EGRTPMHVACQHG 548
Query: 1256 NENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKT 1315
EN+VR+LL GV + ++ + PLH A + GH+ IV LL + +++ G+T
Sbjct: 549 QENIVRILLRR-GVDV-SLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRT 606
Query: 1316 GLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSE 1375
LH+A+ GHY++ +L+ +++N TPLH AA+ GH + +LL GA ++
Sbjct: 607 PLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAV 666
Query: 1376 TNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVL 1435
T+ + AA H ++ L+ ++ D + + +L + H+ + +EE V
Sbjct: 667 TSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHL-AAAHGHSEV-VEELVS 724
Query: 1436 VSPAPVDTAAKLSNIYINLSTKEKERAKDLIAAG 1469
+ LS +++ + + + L+ G
Sbjct: 725 ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHG 758
Score = 105 bits (251), Expect = 2e-21
Identities = 107/371 (28%), Positives = 173/371 (46%), Gaps = 38/371 (10%)
Query: 687 ESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKC 746
+ VD+ + + LH+AVE+ + + LL A+ ++ ++ TPLH+A
Sbjct: 429 QDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNL-SNRRGSTPLHMAVERRVRGVV 487
Query: 747 ALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGET 806
L+L + N ED T +H AA+ G+ ++ LLLE + V D G T
Sbjct: 488 ELLLARK-ISVNAKDEDQWTALHFAAQNGDESSTRLLLE------KNASVNEVD-FEGRT 539
Query: 807 PLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPT 866
P+ +AC+ +IVR L+ +G VS +D LHYA + +P
Sbjct: 540 PMHVACQHGQENIVRILL-----RRGVDVSLQ-----GKDAWLPLHYAA----WQGHLP- 584
Query: 867 ADRQVVKCLIEN-GADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQ 925
+VK L + G V+ QT + T H A G+ V +I D+ +N
Sbjct: 585 ----IVKLLAKQPGVSVNAQTL-DGRTPLHLAAQRGHYRVARILI------DLCSDVNVC 633
Query: 926 NSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNK 985
+ + TPL +A GH LL A + +G +ALHLAA +G+L L+ K
Sbjct: 634 SLLAQTPLHVAAETGHTSTARLLLHRGAGKEAVTSDGYTALHLAARNGHLATVKLLVEEK 693
Query: 986 AFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVC 1045
A + ++ +TALHLAA +G++ +V+ L+ +ID+ + + LHLAA +
Sbjct: 694 ADVLARGPLNQTALHLAAAHGHSEVVEELVSAD--VIDLFDEQGLSALHLAAQGRHAQTV 751
Query: 1046 KLLLELGANID 1056
+ LL GA+I+
Sbjct: 752 ETLLRHGAHIN 762
Score = 92.3 bits (219), Expect = 2e-17
Identities = 105/368 (28%), Positives = 161/368 (43%), Gaps = 36/368 (9%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
GA +H A G LL + +++ T LH+AVE VVE LL V
Sbjct: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + + + T LH AA+ D + +LL+ A N+ +G TP+HVA + G + +
Sbjct: 498 NAK-DEDQWTALHFAAQNGD-ESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRI 555
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL G D + K PL A IV+ L K VS ++A
Sbjct: 556 LLRRGVDVSLQGK-------DAWLPLHYAAWQGHLPIVKLLA------KQPGVS---VNA 599
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
DG + LH A + +V + LI+ +DV++ + +T H A G+
Sbjct: 600 QTLDGRTPLHLAAQ---------RGHYRVARILIDLCSDVNVCSL-LAQTPLHVAAETGH 649
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
++ H S G+T L +A GH+ V L+ A V
Sbjct: 650 TST-ARLLLHRGAGK-----EAVTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLN 703
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
++ALHLAA HG+ +V + L++ I+ G +ALHLAA +A V+ L+R H A I
Sbjct: 704 QTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLR-HGAHI 761
Query: 1023 DVLTLKKQ 1030
++ +LK Q
Sbjct: 762 NLQSLKFQ 769
Score = 91.9 bits (218), Expect = 2e-17
Identities = 89/299 (29%), Positives = 137/299 (45%), Gaps = 35/299 (11%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K D ++H AA+ G LL+K SV+ + T +H+A + + +V LL
Sbjct: 500 KDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR 559
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
G DV ++ GK PLH AA L+ + G N T DG TP+H+AA+ G+
Sbjct: 560 GVDVSLQ-GKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYR 618
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+L++ D VC + +TPL +A + R L+ H+G A
Sbjct: 619 VARILIDLCSD----VNVC---SLLAQTPLHVAAETGHTSTARLLL-----HRG-----A 661
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
+AV DG +ALH A + VK L+E ADV + N +TA H A
Sbjct: 662 GKEAVTSDGYTALHLAAR---------NGHLATVKLLVEEKADVLARGPLN-QTALHLAA 711
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
G+++V+ E++ +ADV + Q G + L +A H Q V TLL + A +++
Sbjct: 712 AHGHSEVVEELV----SADVIDLFDEQ---GLSALHLAAQGRHAQTVETLLRHGAHINL 763
Score = 87.8 bits (208), Expect = 4e-16
Identities = 51/157 (32%), Positives = 83/157 (52%), Gaps = 2/157 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+RG PL +AVE + +V LL+ + + K TALH AA+ D R+L++
Sbjct: 469 RRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQW--TALHFAAQNGDESSTRLLLEK 526
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A V+ + G+TP+H+A G E +V+ + ++ + P+H AA GH I+
Sbjct: 527 NASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIV 586
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+LLA + S+ +T DG T +H+A+ GH A +L
Sbjct: 587 KLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARIL 623
Score = 87.4 bits (207), Expect = 5e-16
Identities = 52/148 (35%), Positives = 80/148 (54%), Gaps = 2/148 (1%)
Query: 65 VPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVV 124
+PL A G+ +V+ LL+ Q + A T G T LHLAA+R +ARIL+D + V
Sbjct: 572 LPLHYAAWQGHLPIVK-LLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDV 630
Query: 125 DATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
+ + QTPLH+AA G + A ++ T +HLAA NGH A ++LL
Sbjct: 631 NVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAVTSDGYTALHLAARNGHLATVKLLV 690
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHAD 212
++ KA + R T +H+A+ +GH++
Sbjct: 691 EE-KADVLARGPLNQTALHLAAAHGHSE 717
Score = 81.4 bits (192), Expect = 3e-14
Identities = 52/161 (32%), Positives = 79/161 (49%), Gaps = 5/161 (3%)
Query: 1239 LGAESGLTPLHLAAYNGNENVVR-LLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGL 1297
L +SG + LHLA G E + LLLN+A SN G PLH+A +V L
Sbjct: 433 LALDSGASLLHLAVEAGQEECAKWLLLNNANPN---LSNRRGSTPLHMAVERRVRGVVEL 489
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
LL+R +++ D T LH A+ +G +LL + A +N D G TP+H A + G
Sbjct: 490 LLARKIS-VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHG 548
Query: 1358 HLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYL 1398
N+V++L G + P+ +AA + H +++ L
Sbjct: 549 QENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLL 589
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/170 (27%), Positives = 82/170 (48%), Gaps = 4/170 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ PL LA + G+ + R L+ + + T LH+AA AR+L+ GA
Sbjct: 604 GRTPLHLAAQRGHYRVARILIDL--CSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGA 661
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+A G T LH+AA G VK +A+ ++T +HLAA +GH+ ++E
Sbjct: 662 GKEAVTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEE 721
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFE 232
L +F+ + G + +H+A+ HA L + G ++++ + F+
Sbjct: 722 LVSADVIDLFD--EQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQ 769
Score = 72.9 bits (171), Expect = 1e-11
Identities = 51/164 (31%), Positives = 74/164 (45%), Gaps = 3/164 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
DL G L LAVEAG + + LL L + G T LH+A RR + +
Sbjct: 432 DLALDSGASLLHLAVEAGQEECAKWLLLNNANPNL--SNRRGSTPLHMAVERRVRGVVEL 489
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+ V+A + T LH AA GDE + A+ D E RTPMH+A ++G
Sbjct: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQ 549
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
I+ +L + + + KD +H A+ GH +L K+
Sbjct: 550 ENIVRILLRR-GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQ 592
Score = 69.7 bits (163), Expect = 1e-10
Identities = 46/166 (27%), Positives = 81/166 (48%), Gaps = 4/166 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
K L+ A+ +G+ S + ++L Q + +G + LHLA + A+ L+ A
Sbjct: 407 KKKLVDAIVSGDTSKLMKILQPQDVD---LALDSGASLLHLAVEAGQEECAKWLLLNNAN 463
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
+ +N G TPLH+A +V+ + + D + T +H AA+NG + LL
Sbjct: 464 PNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLL 523
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+K AS+ E +G T MH+A +G + +L ++GV + + K
Sbjct: 524 LEK-NASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGK 568
Score = 59.3 bits (137), Expect = 1e-07
Identities = 39/128 (30%), Positives = 61/128 (47%), Gaps = 1/128 (0%)
Query: 1277 ENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG 1336
++G + LHLA G LL +A + ++R G T LH+A +VE+LL +
Sbjct: 436 DSGASLLHLAVEAGQEECAKWLLLNNANP-NLSNRRGSTPLHMAVERRVRGVVELLLARK 494
Query: 1337 AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLE 1396
+NA D++ WT LH AA+ G + +LL E AS P+ A +++
Sbjct: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554
Query: 1397 YLLHKEHD 1404
LL + D
Sbjct: 555 ILLRRGVD 562
>AK027424-1|BAB55102.1| 784|Homo sapiens protein ( Homo sapiens cDNA
FLJ14518 fis, clone NT2RM1000850, weakly similar to
ANKYRIN R. ).
Length = 784
Score = 151 bits (366), Expect = 3e-35
Identities = 113/377 (29%), Positives = 181/377 (48%), Gaps = 23/377 (6%)
Query: 907 TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSAL 966
++++ + DV AL+ S+ L +A G + LL N+A ++ + G + L
Sbjct: 420 SKLMKILQPQDVDLALDSGASL----LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL 475
Query: 967 HLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
H+A E V + LL K +N+K + TALH AA NG + L+ + NA ++ +
Sbjct: 476 HMAVERRVRGVVERLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLL-EKNASVNEVD 534
Query: 1027 LKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP 1086
+ TP+H+A GQ + ++LL G ++ + P+H AA + +V+L +Q
Sbjct: 535 FEGLTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPG 594
Query: 1087 NLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHAD 1146
V A T DG T H+AA +G +V L+ D ++ + L TPL +AAE GH
Sbjct: 595 VSVNAQTLDGRTPLHLAAQRGHYRVARILI--DLCSDVNVCSLLAQ-TPLHVAAETGHTS 651
Query: 1147 VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
R+L+ GA G TA+HLAA +GH + ++ ++ L T LH+AA
Sbjct: 652 TARLLLHRGAGKEAVTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAA 711
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLL-N 1265
+G +E V EL+S + V L E GL+ LHLAA + V LL +
Sbjct: 712 AHGHSEVVEELVS--------------ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRH 757
Query: 1266 SAGVQADAASNENGYNP 1282
A + + + G+ P
Sbjct: 758 GAHINLQSLKFQGGHGP 774
Score = 147 bits (356), Expect = 4e-34
Identities = 104/346 (30%), Positives = 167/346 (48%), Gaps = 23/346 (6%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+D + GAS LH A + +EE K L+ N A+ +L R T H
Sbjct: 431 VDLALDSGASLLHLAVEAGQEEC---------AKWLLLNNANPNLSNRRG-STPLHMAVE 480
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
V+ ++A ++N ++ WT L A G LL +A V+ D
Sbjct: 481 RRVRGVVERLLAR------KISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
EG + +H+A +HG + LL ++ + ++ LH AA G+ +VK L +
Sbjct: 535 FEGLTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPG 594
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
++ TL +TPLHLAA G V ++L++L ++++ L Q P+H AA+ ++ +
Sbjct: 595 VSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTAR 654
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLA 1139
L L + A T DG T H+AA G + ++ L++ ++ V+ AR LN T L LA
Sbjct: 655 LLLHRGAG-KEAVTSDGYTALHLAARNGHLATVKLLVE-EKADVL-ARGPLN-QTALHLA 710
Query: 1140 AEGGHADVVRVLVRAGA-SCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
A GH++VV LV A DE GL+A+HLAA+ H ++ +
Sbjct: 711 AAHGHSEVVEELVSADVIDLFDEQ--GLSALHLAAQGRHAQTVETL 754
Score = 133 bits (322), Expect = 6e-30
Identities = 114/349 (32%), Positives = 163/349 (46%), Gaps = 25/349 (7%)
Query: 994 NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA 1053
+G + LHLA G K+L+ + NA ++ + TPLH+A V + LL
Sbjct: 437 SGASLLHLAVEAGQEECAKWLLLN-NANPNLSNRRGSTPLHMAVERRVRGVVERLLARKI 495
Query: 1054 NIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIE 1113
+++A DE +H AAQN +L L+++ + V +G T H+A G ++
Sbjct: 496 SVNAKDEDQWTALHFAAQNGDESSTRLLLEKNAS-VNEVDFEGLTPMHVACQHGQENIVR 554
Query: 1114 ELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLA 1172
L+ R GV + + PL AA GH +V++L + G S + G T +HLA
Sbjct: 555 ILL---RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLA 611
Query: 1173 AEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
A+ GH V ++ + L TPLH+AA G T R LL G EA T
Sbjct: 612 AQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAG---KEAVTS 668
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS-AGVQADAASNENGYNPLHLACFGGH 1291
G T LHLAA NG+ V+LL+ A V A N+ LHLA GH
Sbjct: 669 ----------DGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTA---LHLAAAHGH 715
Query: 1292 MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN 1340
+V L+S A+++ D G + LH+A+ H Q VE LL GA IN
Sbjct: 716 SEVVEELVS--ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
Score = 122 bits (294), Expect = 1e-26
Identities = 88/334 (26%), Positives = 155/334 (46%), Gaps = 17/334 (5%)
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK 1195
L LA E G + + L+ A+ NR G T +H+A E V++ + + +
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVERLLARKISVNAKD 501
Query: 1196 KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNG 1255
+ T LH AA G + R LL K+ + V GLTP+H+A +G
Sbjct: 502 EDQWTALHFAAQNGDESSTRLLLE------KNASVNEVDF-------EGLTPMHVACQHG 548
Query: 1256 NENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKT 1315
EN+VR+LL GV + ++ + PLH A + GH+ IV LL + +++ G+T
Sbjct: 549 QENIVRILLRR-GVDV-SLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRT 606
Query: 1316 GLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSE 1375
LH+A+ GHY++ +L+ +++N TPLH AA+ GH + +LL GA ++
Sbjct: 607 PLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAV 666
Query: 1376 TNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVL 1435
T+ + AA H ++ L+ ++ D + + +L + H+ + +EE V
Sbjct: 667 TSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHL-AAAHGHSEV-VEELVS 724
Query: 1436 VSPAPVDTAAKLSNIYINLSTKEKERAKDLIAAG 1469
+ LS +++ + + + L+ G
Sbjct: 725 ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHG 758
Score = 110 bits (264), Expect = 6e-23
Identities = 109/378 (28%), Positives = 172/378 (45%), Gaps = 47/378 (12%)
Query: 740 IPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIY 799
I GD LM + + A + G + +H+A + G LL + +P +
Sbjct: 414 IVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNR---- 469
Query: 800 DVVTGETPLQMACRSCMPDIVRHLIE-----FVKD-----------HKGESVST------ 837
G TPL MA + +V L+ KD G+ ST
Sbjct: 470 ---RGSTPLHMAVERRVRGVVERLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEK 526
Query: 838 -AFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHY 896
A ++ VD +G + +H AC+ +E +V+ L+ G DVSLQ + + HY
Sbjct: 527 NASVNEVDFEGLTPMHVACQHGQE---------NIVRILLRRGVDVSLQGK-DAWLPLHY 576
Query: 897 CAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVD 956
A G+ ++ +++A VS +N Q G TPL +A RGH ++ L+ + V+
Sbjct: 577 AAWQGHLPIV-KLLA--KQPGVS--VNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVN 631
Query: 957 VFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIR 1016
V + ++ LH+AAE G+ LL A + +G TALHLAA NG+ VK L+
Sbjct: 632 VCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAVTSDGYTALHLAARNGHLATVKLLVE 691
Query: 1017 DHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSE 1076
+ ++ L QT LHLAAA G EV + L+ ID DE G +H AAQ +++
Sbjct: 692 EKADVLARGPL-NQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQ 749
Query: 1077 VVQLFLQQHPNLVMATTK 1094
V+ L+ ++ + + K
Sbjct: 750 TVETLLRHGAHINLQSLK 767
Score = 101 bits (242), Expect = 3e-20
Identities = 109/372 (29%), Positives = 173/372 (46%), Gaps = 40/372 (10%)
Query: 687 ESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAA-RIPDGDK 745
+ VD+ + + LH+AVE+ + + LL A+ ++ ++ TPLH+A R G
Sbjct: 429 QDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNL-SNRRGSTPLHMAVERRVRG-- 485
Query: 746 CALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGE 805
LL N ED T +H AA+ G+ ++ LLLE + V D G
Sbjct: 486 VVERLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLE------KNASVNEVD-FEGL 538
Query: 806 TPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIP 865
TP+ +AC+ +IVR L+ +G VS +D LHYA + +P
Sbjct: 539 TPMHVACQHGQENIVRILL-----RRGVDVSLQ-----GKDAWLPLHYAA----WQGHLP 584
Query: 866 TADRQVVKCLIEN-GADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNR 924
+VK L + G V+ QT + T H A G+ V +I D+ +N
Sbjct: 585 -----IVKLLAKQPGVSVNAQTL-DGRTPLHLAAQRGHYRVARILI------DLCSDVNV 632
Query: 925 QNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTN 984
+ + TPL +A GH LL A + +G +ALHLAA +G+L L+
Sbjct: 633 CSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAVTSDGYTALHLAARNGHLATVKLLVEE 692
Query: 985 KAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEV 1044
KA + ++ +TALHLAA +G++ +V+ L+ +ID+ + + LHLAA +
Sbjct: 693 KADVLARGPLNQTALHLAAAHGHSEVVEELVSAD--VIDLFDEQGLSALHLAAQGRHAQT 750
Query: 1045 CKLLLELGANID 1056
+ LL GA+I+
Sbjct: 751 VETLLRHGAHIN 762
Score = 93.5 bits (222), Expect = 7e-18
Identities = 105/368 (28%), Positives = 162/368 (44%), Gaps = 36/368 (9%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
GA +H A G LL + +++ T LH+AVE VVE LL V
Sbjct: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVERLLARKISV 497
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + + + T LH AA+ D + +LL+ A N+ +G+TP+HVA + G + +
Sbjct: 498 NAK-DEDQWTALHFAAQNGD-ESSTRLLLEKNASVNEVDFEGLTPMHVACQHGQENIVRI 555
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL G D + K PL A IV+ L K VS ++A
Sbjct: 556 LLRRGVDVSLQGK-------DAWLPLHYAAWQGHLPIVKLLA------KQPGVS---VNA 599
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
DG + LH A + +V + LI+ +DV++ + +T H A G+
Sbjct: 600 QTLDGRTPLHLAAQ---------RGHYRVARILIDLCSDVNVCSL-LAQTPLHVAAETGH 649
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
++ H S G+T L +A GH+ V L+ A V
Sbjct: 650 TST-ARLLLHRGAGK-----EAVTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLN 703
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
++ALHLAA HG+ +V + L++ I+ G +ALHLAA +A V+ L+R H A I
Sbjct: 704 QTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLR-HGAHI 761
Query: 1023 DVLTLKKQ 1030
++ +LK Q
Sbjct: 762 NLQSLKFQ 769
Score = 92.3 bits (219), Expect = 2e-17
Identities = 89/299 (29%), Positives = 137/299 (45%), Gaps = 35/299 (11%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K D ++H AA+ G LL+K SV+ + T +H+A + + +V LL
Sbjct: 500 KDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGLTPMHVACQHGQENIVRILLRR 559
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
G DV ++ GK PLH AA L+ + G N T DG TP+H+AA+ G+
Sbjct: 560 GVDVSLQ-GKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYR 618
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+L++ D VC + +TPL +A + R L+ H+G A
Sbjct: 619 VARILIDLCSD----VNVC---SLLAQTPLHVAAETGHTSTARLLL-----HRG-----A 661
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
+AV DG +ALH A + VK L+E ADV + N +TA H A
Sbjct: 662 GKEAVTSDGYTALHLAAR---------NGHLATVKLLVEEKADVLARGPLN-QTALHLAA 711
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
G+++V+ E++ +ADV + Q G + L +A H Q V TLL + A +++
Sbjct: 712 AHGHSEVVEELV----SADVIDLFDEQ---GLSALHLAAQGRHAQTVETLLRHGAHINL 763
Score = 87.8 bits (208), Expect = 4e-16
Identities = 51/157 (32%), Positives = 82/157 (52%), Gaps = 2/157 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+RG PL +AVE + +V LL+ + + K TALH AA+ D R+L++
Sbjct: 469 RRGSTPLHMAVERRVRGVVERLLARKISVNAKDEDQW--TALHFAAQNGDESSTRLLLEK 526
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
A V+ + G TP+H+A G E +V+ + ++ + P+H AA GH I+
Sbjct: 527 NASVNEVDFEGLTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIV 586
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+LLA + S+ +T DG T +H+A+ GH A +L
Sbjct: 587 KLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARIL 623
Score = 87.4 bits (207), Expect = 5e-16
Identities = 52/148 (35%), Positives = 80/148 (54%), Gaps = 2/148 (1%)
Query: 65 VPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVV 124
+PL A G+ +V+ LL+ Q + A T G T LHLAA+R +ARIL+D + V
Sbjct: 572 LPLHYAAWQGHLPIVK-LLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDV 630
Query: 125 DATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
+ + QTPLH+AA G + A ++ T +HLAA NGH A ++LL
Sbjct: 631 NVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAVTSDGYTALHLAARNGHLATVKLLV 690
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHAD 212
++ KA + R T +H+A+ +GH++
Sbjct: 691 EE-KADVLARGPLNQTALHLAAAHGHSE 717
Score = 79.4 bits (187), Expect = 1e-13
Identities = 51/161 (31%), Positives = 78/161 (48%), Gaps = 5/161 (3%)
Query: 1239 LGAESGLTPLHLAAYNGNENVVR-LLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGL 1297
L +SG + LHLA G E + LLLN+A SN G PLH+A +V
Sbjct: 433 LALDSGASLLHLAVEAGQEECAKWLLLNNANPN---LSNRRGSTPLHMAVERRVRGVVER 489
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
LL+R +++ D T LH A+ +G +LL + A +N D G TP+H A + G
Sbjct: 490 LLARKIS-VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGLTPMHVACQHG 548
Query: 1358 HLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYL 1398
N+V++L G + P+ +AA + H +++ L
Sbjct: 549 QENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLL 589
Score = 79.4 bits (187), Expect = 1e-13
Identities = 47/170 (27%), Positives = 82/170 (48%), Gaps = 4/170 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ PL LA + G+ + R L+ + + T LH+AA AR+L+ GA
Sbjct: 604 GRTPLHLAAQRGHYRVARILIDL--CSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGA 661
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+A G T LH+AA G VK +A+ ++T +HLAA +GH+ ++E
Sbjct: 662 GKEAVTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEE 721
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFE 232
L +F+ + G + +H+A+ HA L + G ++++ + F+
Sbjct: 722 LVSADVIDLFD--EQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQ 769
Score = 68.9 bits (161), Expect = 2e-10
Identities = 46/166 (27%), Positives = 81/166 (48%), Gaps = 4/166 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
K L+ A+ +G+ S + ++L Q + +G + LHLA + A+ L+ A
Sbjct: 407 KKKLVDAIVSGDTSKLMKILQPQDVD---LALDSGASLLHLAVEAGQEECAKWLLLNNAN 463
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
+ +N G TPLH+A +V+ + + D + T +H AA+NG + LL
Sbjct: 464 PNLSNRRGSTPLHMAVERRVRGVVERLLARKISVNAKDEDQWTALHFAAQNGDESSTRLL 523
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+K AS+ E +G T MH+A +G + +L ++GV + + K
Sbjct: 524 LEK-NASVNEVDFEGLTPMHVACQHGQENIVRILLRRGVDVSLQGK 568
Score = 68.1 bits (159), Expect = 3e-10
Identities = 50/164 (30%), Positives = 72/164 (43%), Gaps = 3/164 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
DL G L LAVEAG + + LL L + G T LH+A RR +
Sbjct: 432 DLALDSGASLLHLAVEAGQEECAKWLLLNNANPNL--SNRRGSTPLHMAVERRVRGVVER 489
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+ V+A + T LH AA GDE + A+ D E TPMH+A ++G
Sbjct: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGLTPMHVACQHGQ 549
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
I+ +L + + + KD +H A+ GH +L K+
Sbjct: 550 ENIVRILLRR-GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQ 592
Score = 58.4 bits (135), Expect = 3e-07
Identities = 39/128 (30%), Positives = 60/128 (46%), Gaps = 1/128 (0%)
Query: 1277 ENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG 1336
++G + LHLA G LL +A + ++R G T LH+A +VE LL +
Sbjct: 436 DSGASLLHLAVEAGQEECAKWLLLNNANP-NLSNRRGSTPLHMAVERRVRGVVERLLARK 494
Query: 1337 AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLE 1396
+NA D++ WT LH AA+ G + +LL E AS P+ A +++
Sbjct: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGLTPMHVACQHGQENIVR 554
Query: 1397 YLLHKEHD 1404
LL + D
Sbjct: 555 ILLRRGVD 562
>AB209339-1|BAD92576.1| 1055|Homo sapiens tankyrase, TRF1-interacting
ankyrin-related ADP-ribose polymerase variant protein.
Length = 1055
Score = 150 bits (363), Expect = 6e-35
Identities = 134/472 (28%), Positives = 220/472 (46%), Gaps = 45/472 (9%)
Query: 933 LLIACHRGHMQLVNTLLTNHARVDVFDVEGRSA--LHLAAEHGYLQVCDALLTNKAFINS 990
LL A G+ + + LLT V+ +GR + LHLAA + +++ LL + A +++
Sbjct: 67 LLEAARSGNEEKLMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHA 125
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K + G LH A G+ + + L++ H A ++ + L + TPLH AA+ ++EVC LLL
Sbjct: 126 KDKGGLVPLHNACSYGHYEVTELLLK-HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLS 184
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
GA+ + G+ + A E + + H L A D +A ++ ++
Sbjct: 185 HGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREAD------LAKVKKTLA 238
Query: 1111 VIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA---DVVRVLVRAGASCTDENRAGLT 1167
+ E++ F + + T L A H V +L+R GA+ ++N+ +T
Sbjct: 239 L--EIINF--------KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMT 288
Query: 1168 AVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKS 1227
+H+AAE H +V++V+ + LG T LH AA G +T R LLS+
Sbjct: 289 PLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSY------G 342
Query: 1228 EAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLAC 1287
P+ +SL G T AA GNE V ++L S ++ +++ Y L +
Sbjct: 343 SDPSIISL-------QGFT----AAQMGNEAVQQILSESTPIR----TSDVDYRLLEASK 387
Query: 1288 FGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGW 1347
G ++ L S++ RH T LH A+ + +VE LL GA+++A DK G
Sbjct: 388 AGDLETVKQLCSSQNVNCRDLEGRHS-TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGL 446
Query: 1348 TPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
PLH A GH V +LL GAS P+ AA++ ++ + LL
Sbjct: 447 VPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLL 498
Score = 147 bits (356), Expect = 4e-34
Identities = 192/714 (26%), Positives = 307/714 (42%), Gaps = 83/714 (11%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVV-------------- 712
+H AA G + + LLQ G ++ D +AL +A S K +
Sbjct: 14 LHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARS 73
Query: 713 ---ETLLGY----GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGM 765
E L+ + H G+ + TPLH+AA + + +LL+ GA + + G+
Sbjct: 74 GNEEKLMALLTPLNVNCHASDGR-KSTPLHLAAGY-NRVRIVQLLLQHGADVHAKDKGGL 131
Query: 766 TPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGE-TPLQMACRSCMPDIVRHLI 824
P+H A +G+ LLL+ G C+ + + TPL A ++ L+
Sbjct: 132 VPLHNACSYGHYEVTELLLKHGA--------CVNAMDLWQFTPLHEAASKNRVEVCSLLL 183
Query: 825 EFVKDHKGESV--STAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
D + +A A + L Y K AD VK + +
Sbjct: 184 SHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEI-I 242
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ + +HETA H CA+A + ++ + + +N +N TPL +A R H
Sbjct: 243 NFKQPQSHETALH-CAVASLHPKRKQVTELLLRKGAN--VNEKNKDFMTPLHVAAERAHN 299
Query: 943 QLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLA 1002
++ L + A+++ D G++ALH AA G+LQ C LL+ + + + G TA A
Sbjct: 300 DVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTA---A 356
Query: 1003 AMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELG 1062
M A V+ ++ + + T L A+ +G +E K L N++ D G
Sbjct: 357 QMGNEA--VQQILSEST---PIRTSDVDYRLLEASKAGDLETVKQLCS-SQNVNCRDLEG 410
Query: 1063 Q--KPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDR 1120
+ P+H AA N VV+ +L H V A K G H A G +V E L++
Sbjct: 411 RHSTPLHFAAGYNRVSVVE-YLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGA 469
Query: 1121 TGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNV 1180
+ ++ K TPL AA G ++ ++L++ GA T +NR G T + L E G T++
Sbjct: 470 SVNVADLWKF---TPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKE-GDTDI 525
Query: 1181 LDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLG 1240
D++R L ++KK G V++L + P ++ G
Sbjct: 526 QDLLRGDAALLDAAKK------------GCLARVQKLCT----------PENINCRDTQG 563
Query: 1241 AESGLTPLHLAA-YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLL 1299
S TPLHLAA YN E LL + A V A ++ G PLH A GH+ I LL+
Sbjct: 564 RNS--TPLHLAAGYNNLEVAEYLLEHGADVN---AQDKGGLIPLHNAASYGHVDIAALLI 618
Query: 1300 SRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCA 1353
+ +++TD+ T LH A+ G Q+ +LL GA+ ++ G TPL A
Sbjct: 619 KYNT-CVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 671
Score = 136 bits (328), Expect = 1e-30
Identities = 116/422 (27%), Positives = 184/422 (43%), Gaps = 20/422 (4%)
Query: 976 QVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHL 1035
QV + LL A +N K ++ T LH+AA + +++ L + H A ++ L QT LH
Sbjct: 267 QVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHK-HGAKMNALDTLGQTALHR 325
Query: 1036 AAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKD 1095
AA +G ++ C+LLL G++ G AAQ V Q+ + P T D
Sbjct: 326 AALAGHLQTCRLLLSYGSDPSIISLQG----FTAAQMGNEAVQQILSESTP----IRTSD 377
Query: 1096 GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAG 1155
+ A+ G ++ +++L + STPL AA VV L+ G
Sbjct: 378 VDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGR--HSTPLHFAAGYNRVSVVEYLLHHG 435
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
A +++ GL +H A +GH V +++ + TPLH AA G+ E +
Sbjct: 436 ADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICK 495
Query: 1216 ELLSHVPGTVKS--EAPTGVSLVP-----VLGAESGLTPLHLAAYNGNENVVRLLLNSAG 1268
LL H K + T + LV + G L AA G V+ L
Sbjct: 496 LLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPEN 555
Query: 1269 VQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQM 1328
+ N PLHLA ++ + LL A++ ++ D+ G LH A+++GH +
Sbjct: 556 INCRDTQGRNS-TPLHLAAGYNNLEVAEYLLEHGADV-NAQDKGGLIPLHNAASYGHVDI 613
Query: 1329 VEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAAS 1388
+L+ +NATDK +TPLH AA+ G + LL GA P + P+ A +
Sbjct: 614 AALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 673
Query: 1389 EN 1390
++
Sbjct: 674 DD 675
Score = 118 bits (285), Expect = 2e-25
Identities = 162/596 (27%), Positives = 251/596 (42%), Gaps = 73/596 (12%)
Query: 662 DGARS--IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYG 719
DG +S +H AA Y V I+ LLQ G V LH A V E LL +G
Sbjct: 94 DGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHG 153
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAA------- 772
A V+ Q TPLH AA + C+L LL GA P G + V +A
Sbjct: 154 ACVNAMDLWQ-FTPLHEAASKNRVEVCSL-LLSHGADPTLVNCHGKSAVDMAPTPELRER 211
Query: 773 ---KFGNLATLVLLLEDGGDPLRKTK----VCIYDVVTGETPLQMACRSCMPDIVRHLIE 825
+F + L E ++KT + + ET L A S P R +
Sbjct: 212 LTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPK--RKQVT 269
Query: 826 FVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV-SL 884
+ KG +V+ ++D + LH A + A V++ L ++GA + +L
Sbjct: 270 ELLLRKGANVNEK-----NKDFMTPLHVAAE---------RAHNDVMEVLHKHGAKMNAL 315
Query: 885 QTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQL 944
T +TA H A+AG H+ T + + SI A G+ +
Sbjct: 316 DTL--GQTALHRAALAG----------HLQTCRLLLSYGSDPSIISLQGFTAAQMGN-EA 362
Query: 945 VNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGR--TALHLA 1002
V +L+ + DV+ R L A++ G L+ L +++ +N + GR T LH A
Sbjct: 363 VQQILSESTPIRTSDVDYR--LLEASKAGDLETVKQLCSSQN-VNCRDLEGRHSTPLHFA 419
Query: 1003 AMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELG 1062
A +V++L+ H A + PLH A + G EV +LL+ GA+++ D
Sbjct: 420 AGYNRVSVVEYLLH-HGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 478
Query: 1063 QKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA-----IQGSVKVIEELMK 1117
P+H AA E+ +L L +H +DGNT + IQ ++ L+
Sbjct: 479 FTPLHEAAAKGKYEICKLLL-KHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLD 537
Query: 1118 FDRTGVISARNKL-------------NDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
+ G ++ KL +STPL LAA + +V L+ GA +++
Sbjct: 538 AAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKG 597
Query: 1165 GLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSH 1220
GL +H AA +GH ++ ++ NT ++ K TPLH AA G+ + LL+H
Sbjct: 598 GLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAH 653
Score = 99.1 bits (236), Expect = 1e-19
Identities = 96/351 (27%), Positives = 153/351 (43%), Gaps = 26/351 (7%)
Query: 1031 TPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVM 1090
TPLH AA G+I+VC +LL+ GA+ + + G+ + A + S L + + ++
Sbjct: 12 TPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLA---DPSAKAVLTGEYKKDELL 68
Query: 1091 ATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRV 1150
+ GN K++ L + S K STPL LAA +V++
Sbjct: 69 EAARSGN----------EEKLMALLTPLNVNCHASDGRK---STPLHLAAGYNRVRIVQL 115
Query: 1151 LVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQ 1210
L++ GA +++ GL +H A +GH V +++ + TPLH AA +
Sbjct: 116 LLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNR 175
Query: 1211 AETVRELLSH--VPGTVKSEAPTGVSLVPVLGAESGLT---PLHLAAYNGNENVVRLLLN 1265
E LLSH P V + V + P LT H E + +
Sbjct: 176 VEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKK 235
Query: 1266 SAGVQ-ADAASNENGYNPLHLACFGGH---MSIVGLLLSRSAELLHSTDRHGKTGLHIAS 1321
+ ++ + ++ LH A H + LLL + A ++ ++ T LH+A+
Sbjct: 236 TLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGAN-VNEKNKDFMTPLHVAA 294
Query: 1322 THGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASP 1372
H ++EVL GA++NA D G T LH AA AGHL +LL G+ P
Sbjct: 295 ERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDP 345
Score = 98.7 bits (235), Expect = 2e-19
Identities = 133/481 (27%), Positives = 199/481 (41%), Gaps = 52/481 (10%)
Query: 966 LHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVL 1025
LH AA G + VC LL + A N + +G++AL LA + A L
Sbjct: 14 LHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTG------------- 60
Query: 1026 TLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQH 1085
KK L A + + ++ LL L N A+D P+H AA N +VQL LQ H
Sbjct: 61 EYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQ-H 119
Query: 1086 PNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA 1145
V A K G H A G +V E L+K ++A + L TPL AA
Sbjct: 120 GADVHAKDKGGLVPLHNACSYGHYEVTELLLKHG--ACVNAMD-LWQFTPLHEAASKNRV 176
Query: 1146 DVVRVLVRAGASCTDENRAGLTAVHLAAE-----------HGHTNVLDVMRSTNTLRISS 1194
+V +L+ GA T N G +AV +A GH+ +L R + ++
Sbjct: 177 EVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHS-LLQAAREADLAKVK- 234
Query: 1195 KKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESG------LTPL 1248
K L L ++ + Q ++ L ++ + L+ GA +TPL
Sbjct: 235 KTLALEIIN----FKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPL 290
Query: 1249 HLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHS 1308
H+AA + +V+ +L + G + +A G LH A GH+ LLLS ++
Sbjct: 291 HVAAERAHNDVMEVL-HKHGAKMNALDTL-GQTALHRAALAGHLQTCRLLLSYGSDP-SI 347
Query: 1309 TDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCES 1368
G T + + + V+ +L + I +D + L A+KAG L VK LC S
Sbjct: 348 ISLQGFTAAQMGN-----EAVQQILSESTPIRTSDVD--YRLLEASKAGDLETVKQLCSS 400
Query: 1369 -GASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNN 1427
+ + + P+ FAA N V+EYLLH D + D V CS H
Sbjct: 401 QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA-KDKGGLVPLHNACSYGHYE 459
Query: 1428 I 1428
+
Sbjct: 460 V 460
Score = 92.7 bits (220), Expect = 1e-17
Identities = 68/188 (36%), Positives = 91/188 (48%), Gaps = 12/188 (6%)
Query: 1200 TPLHIAAYYGQAETVRELLSHV--PGTVKSEAPTGVSLVP-----VLGAESGLTPLHLAA 1252
TPLH AA G+ + LL H P ++ + + L VL E L AA
Sbjct: 12 TPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAA 71
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
+GNE + LL V A+ PLHLA + IV LLL A++ H+ D+
Sbjct: 72 RSGNEEKLMALLTPLNVNCHASDGRKS-TPLHLAAGYNRVRIVQLLLQHGADV-HAKDKG 129
Query: 1313 GKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASP 1372
G LH A ++GHY++ E+LL GA +NA D +TPLH AA + V LL GA P
Sbjct: 130 GLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADP 189
Query: 1373 KSETNLNC 1380
T +NC
Sbjct: 190 ---TLVNC 194
Score = 67.3 bits (157), Expect = 6e-10
Identities = 96/386 (24%), Positives = 154/386 (39%), Gaps = 41/386 (10%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H AA GH+ LL G + + +TA + E+ + + E+ +DV
Sbjct: 319 GQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDV 378
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLATL 780
R L A++ GD + L S N +G TP+H AA + ++ +
Sbjct: 379 DYR--------LLEASKA--GDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVV 428
Query: 781 VLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFI 840
LL G D K K G PL AC ++ L+ G SV+ A +
Sbjct: 429 EYLLHHGADVHAKDK-------GGLVPLHNACSYGHYEVAELLVRH-----GASVNVADL 476
Query: 841 ---DAVDEDGASALHYACKVTKEEVKIPTA---DRQVVKCLIENGADVSLQTRHNHETAF 894
+ E A + CK+ + PT D L++ G D +Q + A
Sbjct: 477 WKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEG-DTDIQDLLRGDAAL 535
Query: 895 HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGW--TPLLIACHRGHMQLVNTLLTNH 952
A G +A + +N +++ G TPL +A ++++ LL +
Sbjct: 536 LDAAKKG-------CLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHG 588
Query: 953 ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVK 1012
A V+ D G LH AA +G++ + L+ +N+ + T LH AA G L
Sbjct: 589 ADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCA 648
Query: 1013 FLIRDHNAMIDVLTLKKQTPLHLAAA 1038
L+ H A + + QTPL LA A
Sbjct: 649 LLLA-HGADPTMKNQEGQTPLDLATA 673
Score = 59.3 bits (137), Expect = 1e-07
Identities = 46/158 (29%), Positives = 75/158 (47%), Gaps = 4/158 (2%)
Query: 49 KEWKKLIRDLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARR 108
KE I+DL+ RG LL A + G + V++L + + + T T LHLAA
Sbjct: 519 KEGDTDIQDLL--RGDAALLDAAKKGCLARVQKLCTPENIN-CRDTQGRNSTPLHLAAGY 575
Query: 109 RDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPM 168
++++A L+++GA V+A + G PLH AA+ G + D TP+
Sbjct: 576 NNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 635
Query: 169 HLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIAS 206
H AA+ G + LL A + ++G T + +A+
Sbjct: 636 HEAAQKGRTQLCALLL-AHGADPTMKNQEGQTPLDLAT 672
Score = 58.4 bits (135), Expect = 3e-07
Identities = 46/151 (30%), Positives = 70/151 (46%), Gaps = 3/151 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
LL A +AG+ V++L S+Q + T LH AA V + L+ +GA V A
Sbjct: 382 LLEASKAGDLETVKQLCSSQNVN-CRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA 440
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G PLH A + G + + A+ +AD TP+H AA G I +LL K
Sbjct: 441 KDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLL-K 499
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMML 217
A ++ +DG+T + + G D +L
Sbjct: 500 HGADPTKKNRDGNTPLDLVK-EGDTDIQDLL 529
Score = 54.0 bits (124), Expect = 5e-06
Identities = 40/133 (30%), Positives = 62/133 (46%), Gaps = 3/133 (2%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL LA N + LL + + A G LH AA VD+A +L+ Y
Sbjct: 564 RNSTPLHLAAGYNNLEVAEYLL--EHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYN 621
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLA-AENGHAAII 180
V+AT+ TPLH AA +G L A+ + + E +TP+ LA A++ A +I
Sbjct: 622 TCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLI 681
Query: 181 ELLADKFKASIFE 193
+ + + + F+
Sbjct: 682 DAMPPEALPTCFK 694
Score = 40.3 bits (90), Expect = 0.072
Identities = 26/86 (30%), Positives = 45/86 (52%), Gaps = 4/86 (4%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T LH+AA R D+ +L +GA ++A + GQT LH AA G + ++ +I
Sbjct: 288 TPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 347
Query: 160 ADNEDRTPMHLAAENGHAAIIELLAD 185
+ T AA+ G+ A+ ++L++
Sbjct: 348 ISLQGFT----AAQMGNEAVQQILSE 369
Score = 39.1 bits (87), Expect = 0.17
Identities = 31/90 (34%), Positives = 43/90 (47%), Gaps = 7/90 (7%)
Query: 99 DTALHLAARR---RDVDMARILVDYGAVVDATNGAGQTPLHIAA--AEGDEPLVKYFYGV 153
+TALH A + + +L+ GA V+ N TPLH+AA A D V + +G
Sbjct: 251 ETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGA 310
Query: 154 RANAAIADNEDRTPMHLAAENGHAAIIELL 183
+ NA D +T +H AA GH LL
Sbjct: 311 KMNA--LDTLGQTALHRAALAGHLQTCRLL 338
Score = 38.3 bits (85), Expect = 0.29
Identities = 30/123 (24%), Positives = 46/123 (37%), Gaps = 1/123 (0%)
Query: 99 DTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAA 158
D L A + + +L A++G TPLH+AA +V+ A+
Sbjct: 65 DELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVH 124
Query: 159 IADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF 218
D P+H A GH + ELL K A + T +H A+ + +L
Sbjct: 125 AKDKGGLVPLHNACSYGHYEVTELLL-KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 183
Query: 219 KKG 221
G
Sbjct: 184 SHG 186
Score = 38.3 bits (85), Expect = 0.29
Identities = 22/67 (32%), Positives = 33/67 (49%), Gaps = 1/67 (1%)
Query: 155 ANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCA 214
AN + + TP+H+AAE H ++E+L K A + G T +H A+L GH
Sbjct: 277 ANVNEKNKDFMTPLHVAAERAHNDVMEVL-HKHGAKMNALDTLGQTALHRAALAGHLQTC 335
Query: 215 MMLFKKG 221
+L G
Sbjct: 336 RLLLSYG 342
>BC050586-1|AAH50586.2| 306|Homo sapiens ANKRD44 protein protein.
Length = 306
Score = 148 bits (358), Expect = 2e-34
Identities = 102/319 (31%), Positives = 158/319 (49%), Gaps = 19/319 (5%)
Query: 1052 GANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKV 1111
GA ++A D + P+H A + E VQ+ ++ H V A K+ T H+AA +VK
Sbjct: 3 GARVNAKDNMWLTPLHRAVASRSEEAVQVLIK-HSADVNARDKNWQTPLHVAAANKAVKC 61
Query: 1112 IEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHL 1171
E ++ + +S R T L AA GH ++V +L+ GA+ ++ A+H
Sbjct: 62 AEVIIPLLSSVNVSDRG---GRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHW 118
Query: 1172 AAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT 1231
AA GH +V+ ++ + K G TPLH AA GQ V+ LL+
Sbjct: 119 AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLN-----------L 167
Query: 1232 GVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGH 1291
GV + + G T LH+A YNG + VV L++ G + +N NG+ PLH A H
Sbjct: 168 GVEIDEI--NVYGNTALHIACYNGQDAVVNELIDY-GANVNQPNN-NGFTPLHFAAASTH 223
Query: 1292 MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLH 1351
++ LL + ++ + GK+ LH+ + HG + + L+ G EI+ DK+G TPLH
Sbjct: 224 GALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLH 283
Query: 1352 CAAKAGHLNVVKLLCESGA 1370
AA+ GH ++ L SGA
Sbjct: 284 VAARYGHELLINTLITSGA 302
Score = 134 bits (325), Expect = 2e-30
Identities = 95/307 (30%), Positives = 149/307 (48%), Gaps = 8/307 (2%)
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
+N ++++ TPL A + V L+ + A V+ D ++ LH+AA + ++ + +
Sbjct: 6 VNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVI 65
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
+ + +N R GRTALH AA+NG+ +V L+ A I+ K + LH AA G
Sbjct: 66 IPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLA-KGANINAFDKKDRRALHWAAYMGH 124
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAH 1101
++V LL+ GA + D+ G P+HAAA N VV+ L + GNT H
Sbjct: 125 LDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVY-GNTALH 183
Query: 1102 IAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH-ADVVRVLVRAGASCTD 1160
IA G V+ EL+ + V N N TPL AA H A + +LV GA
Sbjct: 184 IACYNGQDAVVNELIDYG-ANVNQPNN--NGFTPLHFAAASTHGALCLELLVNNGADVNI 240
Query: 1161 ENRAGLTAVHLAAEHGH-TNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
+++ G + +H+ A HG T ++++ + K G TPLH+AA YG + L++
Sbjct: 241 QSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKD-GNTPLHVAARYGHELLINTLIT 299
Query: 1220 HVPGTVK 1226
T K
Sbjct: 300 SGADTAK 306
Score = 128 bits (310), Expect = 2e-28
Identities = 90/293 (30%), Positives = 149/293 (50%), Gaps = 11/293 (3%)
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALN 923
+ + + V+ LI++ ADV+ + + N +T H A +I +S+ +VS
Sbjct: 21 VASRSEEAVQVLIKHSADVNARDK-NWQTPLHVAAANKAVKCAEVIIPLLSSVNVS---- 75
Query: 924 RQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLT 983
+ G T L A GH+++VN LL A ++ FD + R ALH AA G+L V L+
Sbjct: 76 --DRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 133
Query: 984 NKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIE 1043
+ A + K + G T LH AA NG ++VK L+ + ID + + T LH+A +GQ
Sbjct: 134 HGAEVTCKDKKGYTPLHAAASNGQINVVKHLL-NLGVEIDEINVYGNTALHIACYNGQDA 192
Query: 1044 VCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIA 1103
V L++ GAN++ + G P+H AA + + + L + V +KDG + H+
Sbjct: 193 VVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMT 252
Query: 1104 AIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGA 1156
A+ G + L++ G I +K + +TPL +AA GH ++ L+ +GA
Sbjct: 253 AVHGRFTRSQTLIQ--NGGEIDCVDK-DGNTPLHVAARYGHELLINTLITSGA 302
Score = 118 bits (285), Expect = 2e-25
Identities = 94/310 (30%), Positives = 146/310 (47%), Gaps = 22/310 (7%)
Query: 1098 TCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGAS 1157
T H A S + ++ L+K + ++AR+K N TPL +AA V++ +S
Sbjct: 15 TPLHRAVASRSEEAVQVLIK--HSADVNARDK-NWQTPLHVAAANKAVKCAEVIIPLLSS 71
Query: 1158 CTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVREL 1217
+R G TA+H AA +GH +++++ + + K LH AAY G + V L
Sbjct: 72 VNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALL 131
Query: 1218 LSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNE 1277
++H + + G TPLH AA NG NVV+ LLN GV+ D N
Sbjct: 132 INHGAEVTCKD-------------KKGYTPLHAAASNGQINVVKHLLN-LGVEIDEI-NV 176
Query: 1278 NGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIA--STHGHYQMVEVLLGQ 1335
G LH+AC+ G ++V L+ A + + + +G T LH A STHG +E+L+
Sbjct: 177 YGNTALHIACYNGQDAVVNELIDYGANV-NQPNNNGFTPLHFAAASTHGAL-CLELLVNN 234
Query: 1336 GAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVL 1395
GA++N K+G +PLH A G + L ++G P+ AA H ++
Sbjct: 235 GADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLI 294
Query: 1396 EYLLHKEHDT 1405
L+ DT
Sbjct: 295 NTLITSGADT 304
Score = 116 bits (278), Expect = 1e-24
Identities = 89/319 (27%), Positives = 154/319 (48%), Gaps = 19/319 (5%)
Query: 986 AFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVC 1045
A +N+K T LH A + V+ LI+ H+A ++ QTPLH+AAA+ ++
Sbjct: 4 ARVNAKDNMWLTPLHRAVASRSEEAVQVLIK-HSADVNARDKNWQTPLHVAAANKAVKCA 62
Query: 1046 KLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAI 1105
++++ L ++++ +D G+ +H AA N + E+V L L + N+ KD H AA
Sbjct: 63 EVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKD-RRALHWAAY 121
Query: 1106 QGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAG 1165
G + V+ L+ + ++ ++K TPL AA G +VV+ L+ G + N G
Sbjct: 122 MGHLDVVALLI--NHGAEVTCKDK-KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 178
Query: 1166 LTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTV 1225
TA+H+A +G V++ + G TPLH AA ELL V
Sbjct: 179 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELL------V 232
Query: 1226 KSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHL 1285
+ A + ++ G +PLH+ A +G + L+ + G + D +++G PLH+
Sbjct: 233 NNGADVNIQ------SKDGKSPLHMTAVHGRFTRSQTLIQNGG-EIDCV-DKDGNTPLHV 284
Query: 1286 ACFGGHMSIVGLLLSRSAE 1304
A GH ++ L++ A+
Sbjct: 285 AARYGHELLINTLITSGAD 303
Score = 113 bits (271), Expect = 8e-24
Identities = 94/316 (29%), Positives = 151/316 (47%), Gaps = 21/316 (6%)
Query: 953 ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVK 1012
ARV+ D + LH A + L+ + A +N++ +N +T LH+AA N +
Sbjct: 4 ARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAE 63
Query: 1013 FLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN 1072
+I + ++V +T LH AA +G +E+ LLL GANI+A D+ ++ +H AA
Sbjct: 64 VII-PLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYM 122
Query: 1073 NYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLND 1132
+ +VV L + H V K G T H AA G + V++ L+ GV +
Sbjct: 123 GHLDVVALLI-NHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNL---GVEIDEINVYG 178
Query: 1133 STPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAA--EHGHTNVLDVMRSTNTL 1190
+T L +A G VV L+ GA+ N G T +H AA HG + ++ + +
Sbjct: 179 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 238
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHL 1250
I SK G +PLH+ A +G+ + L+ + G + V + G TPLH+
Sbjct: 239 NIQSKD-GKSPLHMTAVHGRFTRSQTLIQN-----------GGEIDCV--DKDGNTPLHV 284
Query: 1251 AAYNGNENVVRLLLNS 1266
AA G+E ++ L+ S
Sbjct: 285 AARYGHELLINTLITS 300
Score = 98.7 bits (235), Expect = 2e-19
Identities = 66/243 (27%), Positives = 120/243 (49%), Gaps = 16/243 (6%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
++ D G +ALH+A ++V L+ GA+++ + + A H+ A
Sbjct: 72 VNVSDRGGRTALHHAAL---------NGHVEMVNLLLAKGANINAFDKKDRR-ALHWAAY 121
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
G+ DV+ +I H A+V+ ++ G+TPL A G + +V LL +D +
Sbjct: 122 MGHLDVVALLINH--GAEVTC----KDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEIN 175
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
V G +ALH+A +G V + L+ A +N NG T LH AA + + L L+ ++
Sbjct: 176 VYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNG 235
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
A +++ + ++PLH+ A G+ + L++ G ID D+ G P+H AA+ + ++
Sbjct: 236 ADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLIN 295
Query: 1080 LFL 1082
+
Sbjct: 296 TLI 298
Score = 94.3 bits (224), Expect = 4e-18
Identities = 58/157 (36%), Positives = 89/157 (56%), Gaps = 5/157 (3%)
Query: 1245 LTPLHLAAYNGNENVVRLLL-NSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSA 1303
LTPLH A + +E V++L+ +SA V A ++N PLH+A + +++ +
Sbjct: 14 LTPLHRAVASRSEEAVQVLIKHSADVNA---RDKNWQTPLHVAAANKAVKCAEVIIPLLS 70
Query: 1304 ELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVK 1363
+ + +DR G+T LH A+ +GH +MV +LL +GA INA DK LH AA GHL+VV
Sbjct: 71 SV-NVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVA 129
Query: 1364 LLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
LL GA + P+ AAS +V+++LL+
Sbjct: 130 LLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLN 166
Score = 93.9 bits (223), Expect = 6e-18
Identities = 97/331 (29%), Positives = 145/331 (43%), Gaps = 36/331 (10%)
Query: 686 GESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDK 745
G V+ N T LH AV S V+ L+ + ADV+ R K +TPLH+AA K
Sbjct: 3 GARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNAR-DKNWQTPLHVAA-ANKAVK 60
Query: 746 CALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGE 805
CA +++ + N + G T +H AA G++ + LLL G + + +D
Sbjct: 61 CAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGAN------INAFD-KKDR 113
Query: 806 TPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIP 865
L A D+V LI +H E + D+ G + LH A
Sbjct: 114 RALHWAAYMGHLDVVALLI----NHGAE------VTCKDKKGYTPLHAAAS--------- 154
Query: 866 TADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQ 925
VVK L+ G ++ + TA H G + V+ E+I D +N+
Sbjct: 155 NGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQDAVVNELI------DYGANVNQP 207
Query: 926 NSIGWTPLLIACHRGHMQLVNTLLTNH-ARVDVFDVEGRSALHLAAEHGYLQVCDALLTN 984
N+ G+TPL A H L LL N+ A V++ +G+S LH+ A HG L+ N
Sbjct: 208 NNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQN 267
Query: 985 KAFINSKARNGRTALHLAAMNGYAHLVKFLI 1015
I+ ++G T LH+AA G+ L+ LI
Sbjct: 268 GGEIDCVDKDGNTPLHVAARYGHELLINTLI 298
Score = 81.0 bits (191), Expect = 4e-14
Identities = 51/151 (33%), Positives = 76/151 (50%), Gaps = 8/151 (5%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA G + ++ LL G +D TALHIA + + AVV L+ YGA+V
Sbjct: 145 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 204
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + TPLH AA G C +L+ +GA N ++DG +P+H+ A G
Sbjct: 205 N-QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQT 263
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACR 813
L+++GG+ + D G TPL +A R
Sbjct: 264 LIQNGGE------IDCVD-KDGNTPLHVAAR 287
Score = 74.5 bits (175), Expect = 4e-12
Identities = 79/287 (27%), Positives = 129/287 (44%), Gaps = 34/287 (11%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA V ++ SV+V+ TALH A + +V LL GA+++
Sbjct: 50 LHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFD 109
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
K R LH AA + D AL L+ GA + G TP+H AA G + + LL
Sbjct: 110 KKDRRA-LHWAAYMGHLDVVAL-LINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNL 167
Query: 787 GGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDED 846
G + ++ +Y G T L +AC + +V LI++ A ++ + +
Sbjct: 168 G---VEIDEINVY----GNTALHIACYNGQDAVVNELIDY----------GANVNQPNNN 210
Query: 847 GASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVM 906
G + LH+A T + ++ L+ NGADV++Q++ + ++ H A+ G
Sbjct: 211 GFTPLHFAAASTHGAL--------CLELLVNNGADVNIQSK-DGKSPLHMTAVHGRFTRS 261
Query: 907 TEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHA 953
+I + D + G TPL +A GH L+NTL+T+ A
Sbjct: 262 QTLIQNGGEIDC------VDKDGNTPLHVAARYGHELLINTLITSGA 302
Score = 70.1 bits (164), Expect = 8e-11
Identities = 41/128 (32%), Positives = 71/128 (55%), Gaps = 3/128 (2%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAV-VETLLGYGAD 721
G ++H A G ++N L+ G +V+ N+ +T LH A S A+ +E L+ GAD
Sbjct: 178 GNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGAD 237
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V+I+ K ++PLH+ A + + L+++G + +DG TP+HVAA++G+ +
Sbjct: 238 VNIQS-KDGKSPLHMTA-VHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLIN 295
Query: 782 LLLEDGGD 789
L+ G D
Sbjct: 296 TLITSGAD 303
Score = 69.7 bits (163), Expect = 1e-10
Identities = 48/165 (29%), Positives = 78/165 (47%), Gaps = 3/165 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL AV + ++ V+ L+ + + + A T LH+AA + V A +++ + V+
Sbjct: 16 PLHRAVASRSEEAVQVLI--KHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVN 73
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
++ G+T LH AA G +V AN D +DR +H AA GH ++ LL +
Sbjct: 74 VSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 133
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
A + + K G T +H A+ NG + L GV + N Y
Sbjct: 134 H-GAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVY 177
Score = 69.7 bits (163), Expect = 1e-10
Identities = 48/168 (28%), Positives = 81/168 (48%), Gaps = 4/168 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L A G+ MV LL+ + A ALH AA +D+ +L+++GA
Sbjct: 79 GRTALHHAALNGHVEMVNLLLAK--GANINAFDKKDRRALHWAAYMGHLDVVALLINHGA 136
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V + G TPLH AA+ G +VK+ + + T +H+A NG A++
Sbjct: 137 EVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNE 196
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGH-ADCAMMLFKKGVYLHMPNK 229
L D + A++ + +G T +H A+ + H A C +L G +++ +K
Sbjct: 197 LID-YGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSK 243
Score = 68.9 bits (161), Expect = 2e-10
Identities = 39/125 (31%), Positives = 65/125 (52%), Gaps = 2/125 (1%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G T LH AA +++ + L++ G +D N G T LHIA G + +V AN
Sbjct: 145 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 204
Query: 158 AIADNEDRTPMHLAAENGHAAI-IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMM 216
+N TP+H AA + H A+ +ELL + A + ++KDG + +H+ +++G +
Sbjct: 205 NQPNNNGFTPLHFAAASTHGALCLELLVNN-GADVNIQSKDGKSPLHMTAVHGRFTRSQT 263
Query: 217 LFKKG 221
L + G
Sbjct: 264 LIQNG 268
Score = 67.7 bits (158), Expect = 4e-10
Identities = 46/151 (30%), Positives = 73/151 (48%), Gaps = 4/151 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL A G ++V+ LL+ ++ G+TALH+A + L+DY
Sbjct: 143 KKGYTPLHAAASNGQINVVKHLLNLGV--EIDEINVYGNTALHIACYNGQDAVVNELIDY 200
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPL-VKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
GA V+ N G TPLH AAA L ++ A+ I + ++P+H+ A +G
Sbjct: 201 GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR 260
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGH 210
+ L I KDG+T +H+A+ GH
Sbjct: 261 SQTLIQN-GGEIDCVDKDGNTPLHVAARYGH 290
Score = 66.5 bits (155), Expect = 1e-09
Identities = 40/130 (30%), Positives = 63/130 (48%), Gaps = 1/130 (0%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T LH A R + ++L+ + A V+A + QTPLH+AAA + + ++ +
Sbjct: 15 TPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV 74
Query: 160 ADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
+D RT +H AA NGH ++ LL K A+I K +H A+ GH D +L
Sbjct: 75 SDRGGRTALHHAALNGHVEMVNLLLAK-GANINAFDKKDRRALHWAAYMGHLDVVALLIN 133
Query: 220 KGVYLHMPNK 229
G + +K
Sbjct: 134 HGAEVTCKDK 143
Score = 64.1 bits (149), Expect = 5e-09
Identities = 46/160 (28%), Positives = 70/160 (43%), Gaps = 1/160 (0%)
Query: 69 LAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATN 128
L V A N+++ + + + G TALH AA V+M +L+ GA ++A +
Sbjct: 50 LHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFD 109
Query: 129 GAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFK 188
+ LH AA G +V A D + TP+H AA NG +++ L +
Sbjct: 110 KKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLN-LG 168
Query: 189 ASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
I E G+T +HIA NG L G ++ PN
Sbjct: 169 VEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 208
Score = 55.6 bits (128), Expect = 2e-06
Identities = 34/109 (31%), Positives = 53/109 (48%), Gaps = 1/109 (0%)
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+A + TPLH A A E V+ A+ D +TP+H+AA N
Sbjct: 3 GARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCA 62
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
E++ +S+ + G T +H A+LNGH + +L KG ++ +K
Sbjct: 63 EVII-PLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDK 110
Score = 54.8 bits (126), Expect = 3e-06
Identities = 63/244 (25%), Positives = 104/244 (42%), Gaps = 26/244 (10%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H AA GHV ++N LL KG +++ + ALH A VV L+ +GA+V
Sbjct: 79 GRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEV 138
Query: 723 HIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ K+ TPLH AA +G LL G ++ G T +H+A G A +
Sbjct: 139 TCK-DKKGYTPLHAAA--SNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVN 195
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
L++ G + + G TPL A S + L+ + G A ++
Sbjct: 196 ELIDYGANVNQPNN-------NGFTPLHFAAASTHGALCLELLV----NNG-----ADVN 239
Query: 842 AVDEDGASALHYAC---KVTKEEVKIPTADRQVVKCLIENG-ADVSLQTRHNHETAFHYC 897
+DG S LH + T+ + I + C+ ++G + + R+ HE +
Sbjct: 240 IQSKDGKSPLHMTAVHGRFTRSQTLIQNGGE--IDCVDKDGNTPLHVAARYGHELLINTL 297
Query: 898 AIAG 901
+G
Sbjct: 298 ITSG 301
Score = 46.8 bits (106), Expect = 8e-04
Identities = 34/122 (27%), Positives = 52/122 (42%), Gaps = 3/122 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMA-RILVDYG 121
G L +A G ++V EL+ + G T LH AA + +LV+ G
Sbjct: 178 GNTALHIACYNGQDAVVNELIDY--GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNG 235
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE 181
A V+ + G++PLH+ A G + D + TP+H+AA GH +I
Sbjct: 236 ADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLIN 295
Query: 182 LL 183
L
Sbjct: 296 TL 297
Score = 41.5 bits (93), Expect = 0.031
Identities = 28/100 (28%), Positives = 45/100 (45%)
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNV 1361
S +++ D T LH A + V+VL+ A++NA DKN TPLH AA +
Sbjct: 2 SGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKC 61
Query: 1362 VKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
+++ +S + AA H +++ LL K
Sbjct: 62 AEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAK 101
Score = 41.1 bits (92), Expect = 0.041
Identities = 20/60 (33%), Positives = 28/60 (46%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DG +H A +G TL+Q G +D D T LH+A ++ TL+ GAD
Sbjct: 244 DGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLITSGAD 303
>AK074173-1|BAB84999.1| 1486|Homo sapiens FLJ00246 protein protein.
Length = 1486
Score = 146 bits (354), Expect = 7e-34
Identities = 140/490 (28%), Positives = 225/490 (45%), Gaps = 46/490 (9%)
Query: 917 DVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGR-SALHLAAEHGYL 975
D R++N G + L +AC G+ +L LL HA V+ +G + L A+ GYL
Sbjct: 240 DEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYL 299
Query: 976 QVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHL 1035
+ LL + A +NS++ G TAL A G+ +VK L+ + A I+ TPL
Sbjct: 300 DIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE-GANIEDHNENGHTPLME 358
Query: 1036 AAASGQIEVCKLLLELGANIDA-TDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTK 1094
AA++G +EV ++LL+ GA I+ ++E + + A + ++V+ L+ + T
Sbjct: 359 AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD- 417
Query: 1095 DGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRA 1154
+ +T A + G V+V L+ D ++ +S PL LAA GGH ++ +L+
Sbjct: 418 EMHTALMEACMDGHVEVARLLL--DSGAQVNMPADSFES-PLTLAACGGHVELAALLIER 474
Query: 1155 GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT-LRISSKKLGLTPLHIAAYYGQAET 1213
GA+ + N G T + AA GH ++ ++ + + +++ T L +A G +E
Sbjct: 475 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSE- 533
Query: 1214 VRELLSHVPGTVKSEAPTGV---------SLVPVL---GAE------SGLTPLHLAAYNG 1255
V + L ++ T + LV L GA +G T L A NG
Sbjct: 534 VADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENG 593
Query: 1256 NENVVRLLLNSAGVQADAASN------------------ENGYNPLHLACFGGHMSIVGL 1297
+ +V +LL AG D + E G PL A GH+ V
Sbjct: 594 HTDVADVLLQ-AGADLDKQEDMKTILEGIDPAKHQEHESEGGRTPLMKAARAGHLCTVQF 652
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
L+S+ A + +T + T + +A GH +VE+LL GA+ K+G T L AAK G
Sbjct: 653 LISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGG 712
Query: 1358 HLNVVKLLCE 1367
H NVV L +
Sbjct: 713 HTNVVSYLLD 722
Score = 143 bits (347), Expect = 5e-33
Identities = 111/368 (30%), Positives = 184/368 (50%), Gaps = 25/368 (6%)
Query: 1054 NIDA-TDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVI 1112
+IDA T+ + A + E+V + + + + K G T +AA G V V+
Sbjct: 1079 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAK-IEHRDKKGFTPLILAATAGHVGVV 1137
Query: 1113 EELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA 1172
E L+ D+ G I A+++ TPL LA GG +VV +L+ GA+ N + T + LA
Sbjct: 1138 EILL--DKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1195
Query: 1173 AEHGHTNVLDVMRSTNTLRISSK---KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEA 1229
A G+ N++ ++ + I+S+ KLG++PL +AA G V+ LL + + ++
Sbjct: 1196 ASGGYVNIIKILLNAGA-EINSRTGSKLGISPLMLAAMNGHVPAVKLLLD-MGSDINAQI 1253
Query: 1230 PTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLN-SAGVQADAASNENGYNPLHLACF 1288
T + T L LA + G VV LLL+ A V+ A + G PL A
Sbjct: 1254 ETNRN-----------TALTLACFQGRAEVVSLLLDRKANVEHRA---KTGLTPLMEAAS 1299
Query: 1289 GGHMSIVGLLLSRSAEL-LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGW 1347
GG+ + +LL + A++ T L IA+ GHY+ E+L+ +GA I+ +K G
Sbjct: 1300 GGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGN 1359
Query: 1348 TPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
TPL A+ GH +VV+LL ++GA + N P+ A + H V++YL+ + + S
Sbjct: 1360 TPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPS 1419
Query: 1408 LMDDKRFV 1415
++ R++
Sbjct: 1420 DIECMRYI 1427
Score = 143 bits (346), Expect = 7e-33
Identities = 146/514 (28%), Positives = 223/514 (43%), Gaps = 50/514 (9%)
Query: 936 ACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNG 995
AC G + V LL V+ EG S L LA GY ++ LL A + + G
Sbjct: 226 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 285
Query: 996 R-TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
T L A+ GY +VK L+ H+A ++ + T L A A G +++ K+LL GAN
Sbjct: 286 DITPLMAASSGGYLDIVKLLLL-HDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 344
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
I+ +E G P+ AA + EV ++ L + + + + +A +G + ++
Sbjct: 345 IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRF 404
Query: 1115 LMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
L++ G T L A GH +V R+L+ +GA + + + LAA
Sbjct: 405 LLE---AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 461
Query: 1175 HGHTNV--LDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL---SHVPGTVKSEA 1229
GH + L + R N ++ + G TPL AA G E V LL +++ +
Sbjct: 462 GGHVELAALLIERGANLEEVNDE--GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ 519
Query: 1230 PTGVSL------------VPVLGAESGL---TPLHLAAYNGNENVVRLLLNS-AGVQADA 1273
T ++L + GA+ L TPL A+ G+ +V+ LL S A V A
Sbjct: 520 ETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATT 579
Query: 1274 ASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD-----------RH-------GKT 1315
A+ G L AC GH + +LL A+L D +H G+T
Sbjct: 580 AT---GDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDPAKHQEHESEGGRT 636
Query: 1316 GLHIASTHGHYQMVEVLLGQGAEIN-ATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKS 1374
L A+ GH V+ L+ +GA +N AT N T + A GHL VV+LL GA P
Sbjct: 637 PLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTH 696
Query: 1375 ETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
+ AA H +V+ YLL ++ S+
Sbjct: 697 RLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSV 730
Score = 134 bits (324), Expect = 3e-30
Identities = 119/411 (28%), Positives = 184/411 (44%), Gaps = 22/411 (5%)
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
V+ RS L A G + LL +N G + L LA GY L + L+ H
Sbjct: 218 VDTRS-LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 276
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
+ D TPL A++ G +++ KLLL A++++ G + A + ++V+
Sbjct: 277 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 336
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLA 1139
+ L + N + ++G+T AA G V+V L+ G+ + N+ +S L LA
Sbjct: 337 VLLNEGAN-IEDHNENGHTPLMEAASAGHVEVARVLLDHG-AGINTHSNEFKESA-LTLA 393
Query: 1140 AEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGL 1199
GH D+VR L+ AGA + TA+ A GH V ++ +
Sbjct: 394 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 453
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
+PL +AA G E L+ G +L V + G TPL AA G+E +
Sbjct: 454 SPLTLAACGGHVELAALLIER-----------GANLEEV--NDEGYTPLMEAAREGHEEM 500
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
V LLL + G +A + E L LAC GG + L+ A++ + T L
Sbjct: 501 VALLL-AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI----ELGCSTPLME 555
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
AS GH ++V+ LL GA ++AT G T L A + GH +V +L ++GA
Sbjct: 556 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 606
Score = 131 bits (317), Expect = 2e-29
Identities = 120/413 (29%), Positives = 189/413 (45%), Gaps = 25/413 (6%)
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A +G + V+ L+ D ++ T + ++ L LA ++G E+ ++LL + AN++
Sbjct: 226 ACSDGDVNAVRKLL-DEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 284
Query: 1062 GQ-KPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDR 1120
G P+ AA+ Y ++V+L L H V + + GNT A G V +++ L+ +
Sbjct: 285 GDITPLMAASSGGYLDIVKLLLL-HDADVNSQSATGNTALTYACAGGFVDIVKVLL--NE 341
Query: 1121 TGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASC-TDENRAGLTAVHLAAEHGHTN 1179
I N+ N TPL AA GH +V RVL+ GA T N +A+ LA GH +
Sbjct: 342 GANIEDHNE-NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 400
Query: 1180 VLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVL 1239
++ + + T L A G E R LL +G + +
Sbjct: 401 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD-----------SGAQVN--M 447
Query: 1240 GAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLL 1299
A+S +PL LAA G+ + LL+ G + N+ GY PL A GH +V LLL
Sbjct: 448 PADSFESPLTLAACGGHVELAALLIER-GANLEEV-NDEGYTPLMEAAREGHEEMVALLL 505
Query: 1300 SRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
++ A + T+ +T L +A G ++ + L+ GA+I TPL A++ GHL
Sbjct: 506 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHL 562
Query: 1360 NVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDK 1412
+VK L SGA+ + T + +A H DV + LL D D K
Sbjct: 563 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 615
Score = 129 bits (312), Expect = 9e-29
Identities = 151/539 (28%), Positives = 237/539 (43%), Gaps = 58/539 (10%)
Query: 665 RSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHI 724
RS+ A G V + LL +G SV+ T + + L +A + + + LL A+V
Sbjct: 221 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 280
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLL 784
RG K TPL A+ D L+LL A N + G T + A G + + +LL
Sbjct: 281 RGNKGDITPLMAASSGGYLDIVKLLLLHD-ADVNSQSATGNTALTYACAGGFVDIVKVLL 339
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD 844
+G + + G TPL A + ++ R L+ DH G ++T +
Sbjct: 340 NEGANIEDHNE-------NGHTPLMEAASAGHVEVARVLL----DH-GAGINT----HSN 383
Query: 845 EDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNND 904
E SAL AC +V+ L+E GAD +T H TA + G+ +
Sbjct: 384 EFKESALTLACY---------KGHLDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVE 433
Query: 905 VMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRS 964
V ++ D +N +PL +A GH++L L+ A ++ + EG +
Sbjct: 434 VARLLL------DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYT 487
Query: 965 ALHLAAEHGYLQVCDALLTNKAFINSKARNGR-TALHLAAMNGYAHLVKFLIRDHNAMID 1023
L AA G+ ++ LL A IN++ + TAL LA G++ + FLI+ A D
Sbjct: 488 PLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIK---AGAD 544
Query: 1024 VLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
+ L TPL A+ G +E+ K LL GAN+ AT G + A +N +++V + LQ
Sbjct: 545 I-ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 603
Query: 1084 QHPNL----VMAT--------------TKDGNTCAHIAAIQGSVKVIEELMKFDRTGVIS 1125
+L M T ++ G T AA G + ++ L+ + ++
Sbjct: 604 AGADLDKQEDMKTILEGIDPAKHQEHESEGGRTPLMKAARAGHLCTVQFLI--SKGANVN 661
Query: 1126 ARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
ND T + LA GGH VV +L+ GA T + G T + AA+ GHTNV+ +
Sbjct: 662 RATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 720
Score = 120 bits (289), Expect = 6e-26
Identities = 92/293 (31%), Positives = 145/293 (49%), Gaps = 9/293 (3%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
T L +AC GH +LV+ L+ A+++ D +G + L LAA G++ V + LL I +
Sbjct: 1090 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1149
Query: 991 KA-RNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL 1049
++ R T L LA G +V L+ A + + TPL LAA+ G + + K+LL
Sbjct: 1150 QSERTKDTPLSLACSGGRQEVVDLLLA-RGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1208
Query: 1050 ELGANIDAT--DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQG 1107
GA I++ +LG P+ AA N + V+L L ++ + NT +A QG
Sbjct: 1209 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1268
Query: 1108 SVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGA--SCTDENRAG 1165
+V+ L+ DR + R K TPL AA GG+A+V RVL+ GA + +
Sbjct: 1269 RAEVVSLLL--DRKANVEHRAK-TGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1325
Query: 1166 LTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
TA+ +AA+ GH +++ K G TPL +A+ G + V+ L+
Sbjct: 1326 DTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLV 1378
Score = 114 bits (274), Expect = 4e-24
Identities = 98/346 (28%), Positives = 162/346 (46%), Gaps = 15/346 (4%)
Query: 881 DVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRG 940
D+ T NH+TA G+ ++++ +IA + ++ G+TPL++A G
Sbjct: 1079 DIDAHTESNHDTALTLACAGGHEELVSVLIAR------DAKIEHRDKKGFTPLILAATAG 1132
Query: 941 HMQLVNTLLTNHARVDVFDVEGR-SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTAL 999
H+ +V LL ++ + + L LA G +V D LL A + + T L
Sbjct: 1133 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPL 1192
Query: 1000 HLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQ--TPLHLAAASGQIEVCKLLLELGANIDA 1057
LAA GY +++K L+ + A I+ T K +PL LAA +G + KLLL++G++I+A
Sbjct: 1193 SLAASGGYVNIIKILL-NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINA 1251
Query: 1058 TDELGQK-PIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
E + + A +EVV L L + N V K G T AA G +V L+
Sbjct: 1252 QIETNRNTALTLACFQGRAEVVSLLLDRKAN-VEHRAKTGLTPLMEAASGGYAEVGRVLL 1310
Query: 1117 KFDRTGVISARN-KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEH 1175
D+ ++A + T L +AA+ GH +L+ GA N+ G T + LA+
Sbjct: 1311 --DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNG 1368
Query: 1176 GHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
GH +V+ ++ ++ +TPL A G + V+ L+ V
Sbjct: 1369 GHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEV 1414
Score = 107 bits (258), Expect = 3e-22
Identities = 101/382 (26%), Positives = 165/382 (43%), Gaps = 28/382 (7%)
Query: 1132 DSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT-L 1190
D+ L A G + VR L+ G S + G + + LA G+ + V+ + + +
Sbjct: 219 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 278
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG------------VSLVPV 1238
K +TPL A+ G + V+ LL H V S++ TG V +V V
Sbjct: 279 EDRGNKGDITPLMAASSGGYLDIVKLLLLH-DADVNSQSATGNTALTYACAGGFVDIVKV 337
Query: 1239 L---GA------ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFG 1289
L GA E+G TPL AA G+ V R+LL+ G + SNE + L LAC+
Sbjct: 338 LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH-GAGINTHSNEFKESALTLACYK 396
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP 1349
GH+ +V LL A+ H TD T L A GH ++ +LL GA++N + +P
Sbjct: 397 GHLDMVRFLLEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 455
Query: 1350 LHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLM 1409
L AA GH+ + LL E GA+ + + P+ AA E H +++ LL + + +
Sbjct: 456 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 515
Query: 1410 DDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKERAKDLIAAG 1469
++ + + C + + +F++ + A ++ + + E K L+A+G
Sbjct: 516 EETQETALTLACCGGFSE--VADFLIKAGADIELGCSTPLMEAS-QEGHLELVKYLLASG 572
Query: 1470 KQCEXXXXXXXXXXXXXDSAGH 1491
GH
Sbjct: 573 ANVHATTATGDTALTYACENGH 594
Score = 96.3 bits (229), Expect = 1e-18
Identities = 115/452 (25%), Positives = 189/452 (41%), Gaps = 55/452 (12%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A G V I+ LL +G +++ + +T L A + V LL +GA +
Sbjct: 319 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 378
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + +E+ L +A D LL++GA T++ T + A G++ L
Sbjct: 379 NTHSNEFKESALTLACYKGHLDMVRF-LLEAGADQEHKTDEMHTALMEACMDGHVEVARL 437
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
LL+ G + E+PL +A ++ LIE +G A ++
Sbjct: 438 LLDSGAQVNMPAD-------SFESPLTLAACGGHVELAALLIE-----RG-----ANLEE 480
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGN 902
V+++G + L A + EE+ V L+ GA+++ QT ETA G
Sbjct: 481 VNDEGYTPLMEAAREGHEEM---------VALLLAQGANINAQTEETQETALTLACCGGF 531
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
++V +I + AD+ + TPL+ A GH++LV LL + A V G
Sbjct: 532 SEVADFLIK--AGADIELGCS-------TPLMEASQEGHLELVKYLLASGANVHATTATG 582
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSK-------------------ARNGRTALHLAA 1003
+AL A E+G+ V D LL A ++ + + GRT L AA
Sbjct: 583 DTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDPAKHQEHESEGGRTPLMKAA 642
Query: 1004 MNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQ 1063
G+ V+FLI + T + LA A G + V +LLL GA+ + G
Sbjct: 643 RAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGS 702
Query: 1064 KPIHAAAQNNYSEVVQLFLQQHPNLVMATTKD 1095
+ AA+ ++ VV L N++ T D
Sbjct: 703 TMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTD 734
Score = 90.6 bits (215), Expect = 5e-17
Identities = 66/226 (29%), Positives = 109/226 (48%), Gaps = 5/226 (2%)
Query: 1211 AETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQ 1270
A+T+ + L + V + PTG + LTP + N + V
Sbjct: 1022 AQTLTDTLDDLIAAVSTRVPTGSNSSSQ--TTECLTPESCSQTTSNVASQSMPPVYPSVD 1079
Query: 1271 ADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVE 1330
DA + N L LAC GGH +V +L++R A++ H D+ G T L +A+T GH +VE
Sbjct: 1080 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHR-DKKGFTPLILAATAGHVGVVE 1138
Query: 1331 VLLGQGAEINA-TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASE 1389
+LL +G +I A +++ TPL A G VV LL GA+ + + P+ AAS
Sbjct: 1139 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1198
Query: 1390 NHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVL 1435
+ ++++ LL+ + S K + LM+ + N ++P + +L
Sbjct: 1199 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN-GHVPAVKLLL 1243
Score = 87.8 bits (208), Expect = 4e-16
Identities = 52/179 (29%), Positives = 93/179 (51%), Gaps = 6/179 (3%)
Query: 1246 TPLHLAAYNGNENVVRLLL-NSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAE 1304
T L LA G+E +V +L+ A ++ ++ G+ PL LA GH+ +V +LL + +
Sbjct: 1090 TALTLACAGGHEELVSVLIARDAKIEH---RDKKGFTPLILAATAGHVGVVEILLDKGGD 1146
Query: 1305 LLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKL 1364
+ ++R T L +A + G ++V++LL +GA + + +TPL AA G++N++K+
Sbjct: 1147 IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1206
Query: 1365 LCESGASPKSET--NLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVC 1421
L +GA S T L +P+ AA H ++ LL D + ++ R + C
Sbjct: 1207 LLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLAC 1265
Score = 87.0 bits (206), Expect = 6e-16
Identities = 84/323 (26%), Positives = 151/323 (46%), Gaps = 32/323 (9%)
Query: 764 GMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHL 823
G TP+ +AA G++ + +LL+ GGD +++ T +TPL +AC ++V L
Sbjct: 1121 GFTPLILAATAGHVGVVEILLDKGGDIEAQSER------TKDTPLSLACSGGRQEVVDLL 1174
Query: 824 IEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVS 883
+ + + +VS D A++ Y ++K L+ GA+++
Sbjct: 1175 LARGANKEHRNVS----DYTPLSLAASGGYV---------------NIIKILLNAGAEIN 1215
Query: 884 LQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQ 943
+T + A + +++ + + D++ + + T L +AC +G +
Sbjct: 1216 SRTGSKLGISPLMLAAMNGHVPAVKLLLDMGS-DINAQIETNRN---TALTLACFQGRAE 1271
Query: 944 LVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKA--RNGRTALHL 1001
+V+ LL A V+ G + L AA GY +V LL A +N+ + TAL +
Sbjct: 1272 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1331
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
AA G+ + LI A IDV K TPL LA+ G +V +LL++ GA++DA D
Sbjct: 1332 AADKGHYKFCELLIH-RGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1390
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQ 1084
P+ +A + + +VVQ +++
Sbjct: 1391 KITPLMSAFRKGHVKVVQYLVKE 1413
Score = 73.7 bits (173), Expect = 6e-12
Identities = 81/346 (23%), Positives = 147/346 (42%), Gaps = 29/346 (8%)
Query: 674 GHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETP 733
GH +++ L+ + ++ +T L +A + VVE LL G D+ + + ++TP
Sbjct: 1099 GHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTP 1158
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L +A + +LL GA TP+ +AA G + + +LL G + +
Sbjct: 1159 LSLACS-GGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR 1217
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHY 853
T + G +PL +A + V+ L++ D + ++ + +AL
Sbjct: 1218 TGSKL-----GISPLMLAAMNGHVPAVKLLLDMGSDINAQ---------IETNRNTALTL 1263
Query: 854 ACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHI 913
AC + EV DR K +E+ A L E A A G V+ + A +
Sbjct: 1264 ACFQGRAEVVSLLLDR---KANVEHRAKTGLTPLM--EAASGGYAEVGR--VLLDKGADV 1316
Query: 914 STADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHG 973
+ V + + T L IA +GH + L+ A +DV + +G + L LA+ G
Sbjct: 1317 NAPPVPSSRD-------TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGG 1369
Query: 974 YLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
+ V L+ A +++ T L A G+ +V++L+++ N
Sbjct: 1370 HFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVN 1415
Score = 70.5 bits (165), Expect = 6e-11
Identities = 98/381 (25%), Positives = 164/381 (43%), Gaps = 44/381 (11%)
Query: 611 VPTELLPIIWKPISKDSFYTLNIDTAMELK-SGFFEDRMIFWDTFFEKYKHFD--GARSI 667
V ++ +P ++ + D+ N DTA+ L +G E+ + K +H D G +
Sbjct: 1066 VASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPL 1125
Query: 668 HTAARYGHVGIINTLLQKGESVDV-TTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
AA GHVG++ LL KG ++ + T L +A + VV+ LL GA+ R
Sbjct: 1126 ILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRN 1185
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNLATLVLLL 784
TPL +AA +LL +GA N T G++P+ +AA G++ + LLL
Sbjct: 1186 VSD-YTPLSLAAS-GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 1243
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVK--DHKGESVSTAFIDA 842
+ G D + + T L +AC ++V L++ +H+ ++ T ++A
Sbjct: 1244 DMGSDINAQIE------TNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEA 1297
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSL-QTRHNHETAFHYCAIAG 901
G A +V + L++ GADV+ + +TA A G
Sbjct: 1298 A--SGGYA-------------------EVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1336
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ +I + DV +N G TPL +A + GH +V L+ A VD D
Sbjct: 1337 HYKFCELLIHRGAHIDV------RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1390
Query: 962 GRSALHLAAEHGYLQVCDALL 982
+ L A G+++V L+
Sbjct: 1391 KITPLMSAFRKGHVKVVQYLV 1411
Score = 64.1 bits (149), Expect = 5e-09
Identities = 46/172 (26%), Positives = 82/172 (47%), Gaps = 3/172 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G + L+A +G + +LL A+ + + + G+TAL A VD+ ++L++ G
Sbjct: 284 KGDITPLMAASSGGYLDIVKLLLLHDAD-VNSQSATGNTALTYACAGGFVDIVKVLLNEG 342
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAAENGHAAII 180
A ++ N G TPL AA+ G + + A NE + + + LA GH ++
Sbjct: 343 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 402
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFE 232
L + A +T + T + A ++GH + A +L G ++MP FE
Sbjct: 403 RFLLEA-GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 453
Score = 63.3 bits (147), Expect = 9e-09
Identities = 56/173 (32%), Positives = 79/173 (45%), Gaps = 25/173 (14%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL+ A + G+ +V+ LL++ + ATT GDTAL A D+A +L+ GA +D
Sbjct: 552 PLMEASQEGHLELVKYLLAS--GANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 609
Query: 126 ATNG-------------------AGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNED 164
G+TPL AA G V++ G N A A+N D
Sbjct: 610 KQEDMKTILEGIDPAKHQEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN-D 668
Query: 165 RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
T + LA GH A++ELL A R KDGST++ A+ GH + L
Sbjct: 669 HTVVSLACAGGHLAVVELLL-AHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 720
Score = 62.1 bits (144), Expect = 2e-08
Identities = 51/161 (31%), Positives = 79/161 (49%), Gaps = 4/161 (2%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G+ MVR LL A ++ K T TAL A V++AR+L+D GA V+
Sbjct: 390 LTLACYKGHLDMVRFLLEAGADQEHK--TDEMHTALMEACMDGHVEVARLLLDSGAQVNM 447
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ ++PL +AA G L AN ++E TP+ AA GH ++ LL +
Sbjct: 448 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 507
Query: 187 FKASIFERTKD-GSTLMHIASLNGHADCAMMLFKKGVYLHM 226
A+I +T++ T + +A G ++ A L K G + +
Sbjct: 508 -GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL 547
Score = 62.1 bits (144), Expect = 2e-08
Identities = 48/158 (30%), Positives = 77/158 (48%), Gaps = 6/158 (3%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G++ +V L++ +++ G T L LAA V + IL+D G ++A
Sbjct: 1092 LTLACAGGHEELVSVLIARDA--KIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1149
Query: 127 -TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ TPL +A + G + +V AN + D TP+ LAA G+ II++L +
Sbjct: 1150 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1209
Query: 186 KFKASIFERT--KDGSTLMHIASLNGHADCAMMLFKKG 221
A I RT K G + + +A++NGH +L G
Sbjct: 1210 A-GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG 1246
Score = 59.3 bits (137), Expect = 1e-07
Identities = 36/121 (29%), Positives = 53/121 (43%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL+ A G + R LL + DTAL +AA + +L+ GA
Sbjct: 1290 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGA 1349
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+D N G TPL +A+ G +V+ A+ ADN TP+ A GH +++
Sbjct: 1350 HIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQY 1409
Query: 183 L 183
L
Sbjct: 1410 L 1410
Score = 58.0 bits (134), Expect = 3e-07
Identities = 50/161 (31%), Positives = 75/161 (46%), Gaps = 4/161 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL+LA G+ V+ LL + + T +TAL LA + ++ +L+D A
Sbjct: 1223 GISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR-NTALTLACFQGRAEVVSLLLDRKA 1281
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPMHLAAENGHAAII 180
V+ G TPL AA+ G + + G NA + T + +AA+ GH
Sbjct: 1282 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1341
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
ELL + A I R K G+T + +AS GH D +L + G
Sbjct: 1342 ELLIHR-GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAG 1381
Score = 56.8 bits (131), Expect = 8e-07
Identities = 43/162 (26%), Positives = 75/162 (46%), Gaps = 3/162 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL+LA AG+ +V E+L + + + DT L LA ++ +L+
Sbjct: 1119 KKGFTPLILAATAGHVGVV-EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLAR 1177
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPMHLAAENGHAA 178
GA + N + TPL +AA+ G ++K G N+ +P+ LAA NGH
Sbjct: 1178 GANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVP 1237
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
++LL D + + +T + +A G A+ +L +
Sbjct: 1238 AVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDR 1279
Score = 55.2 bits (127), Expect = 2e-06
Identities = 45/168 (26%), Positives = 77/168 (45%), Gaps = 6/168 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G ++++ LL+A + + G + L LAA V ++L+D G+ ++
Sbjct: 1191 PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDIN 1250
Query: 126 ATNGAGQ-TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A + T L +A +G +V +AN TP+ AA G+A + +L
Sbjct: 1251 AQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1310
Query: 185 DK---FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
DK A ++D T + IA+ GH +L +G ++ + NK
Sbjct: 1311 DKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIHRGAHIDVRNK 1356
Score = 53.6 bits (123), Expect = 7e-06
Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 2/165 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL+ A AG+ + R LL + ++AL LA + +DM R L++
Sbjct: 350 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNE-FKESALTLACYKGHLDMVRFLLEA 408
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA + T L A +G + + A + + +P+ LAA GH +
Sbjct: 409 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 468
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
LL ++ A++ E +G T + A+ GH + +L +G ++
Sbjct: 469 ALLIER-GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 512
Score = 52.4 bits (120), Expect = 2e-05
Identities = 42/125 (33%), Positives = 56/125 (44%), Gaps = 4/125 (3%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V G PL+ A G++ MV LL AQ A T +TAL LA ++A L+
Sbjct: 481 VNDEGYTPLMEAAREGHEEMVA-LLLAQGANINAQTEETQETALTLACCGGFSEVADFLI 539
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
GA ++ TPL A+ EG LVKY AN T + A ENGH
Sbjct: 540 KAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTD 596
Query: 179 IIELL 183
+ ++L
Sbjct: 597 VADVL 601
Score = 51.6 bits (118), Expect = 3e-05
Identities = 45/160 (28%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G+ + L+ + L+ G T L AAR +M +L+ GA ++
Sbjct: 455 PLTLAACGGHVELAALLI--ERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 512
Query: 126 A-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A T +T L +A G + + ++A A I + TP+ A++ GH +++ L
Sbjct: 513 AQTEETQETALTLACCGGFSEVADFL--IKAGADI-ELGCSTPLMEASQEGHLELVKYLL 569
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
A++ T G T + A NGH D A +L + G L
Sbjct: 570 AS-GANVHATTATGDTALTYACENGHTDVADVLLQAGADL 608
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/162 (25%), Positives = 68/162 (41%), Gaps = 3/162 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGD-TALHLAARRRDVDMARILVD 119
+ G+ L LA AG + + LL+ + + GD T L A+ +D+ ++L+
Sbjct: 250 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK--GDITPLMAASSGGYLDIVKLLLL 307
Query: 120 YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
+ A V++ + G T L A A G +VK AN + TP+ AA GH +
Sbjct: 308 HDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEV 367
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+L D + + + +A GH D L + G
Sbjct: 368 ARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 409
Score = 45.6 bits (103), Expect = 0.002
Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 2/121 (1%)
Query: 110 DVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE-DRTPM 168
DV+ R L+D G V+ G++ L +A + G L + + AN N+ D TP+
Sbjct: 231 DVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPL 290
Query: 169 HLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
A+ G+ I++LL A + ++ G+T + A G D +L +G + N
Sbjct: 291 MAASSGGYLDIVKLLL-LHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 349
Query: 229 K 229
+
Sbjct: 350 E 350
Score = 44.8 bits (101), Expect = 0.003
Identities = 34/101 (33%), Positives = 47/101 (46%), Gaps = 5/101 (4%)
Query: 124 VDA-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+DA T T L +A A G E LV A D + TP+ LAA GH ++E+
Sbjct: 1080 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1139
Query: 183 LADKFK--ASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L DK + ERTKD T + +A G + +L +G
Sbjct: 1140 LLDKGGDIEAQSERTKD--TPLSLACSGGRQEVVDLLLARG 1178
Score = 42.7 bits (96), Expect = 0.014
Identities = 23/67 (34%), Positives = 39/67 (58%), Gaps = 1/67 (1%)
Query: 656 EKYKHFDGARSIHTAARYGHVGIINTLLQKGESVD-VTTNDNYTALHIAVESCKPAVVET 714
++++ G + AAR GH+ + L+ KG +V+ T N+++T + +A AVVE
Sbjct: 627 QEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVEL 686
Query: 715 LLGYGAD 721
LL +GAD
Sbjct: 687 LLAHGAD 693
Score = 41.5 bits (93), Expect = 0.031
Identities = 38/130 (29%), Positives = 62/130 (47%), Gaps = 8/130 (6%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY-TALHIAVESCKPAVVETLLGYGA 720
+G + AAR GH ++ LL +G +++ T + TAL +A V + L+ GA
Sbjct: 484 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 543
Query: 721 DVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
D+ + TPL A++ +G + LL SGA + T G T + A + G+
Sbjct: 544 DIEL----GCSTPLMEASQ--EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 597
Query: 780 LVLLLEDGGD 789
+LL+ G D
Sbjct: 598 ADVLLQAGAD 607
Score = 41.1 bits (92), Expect = 0.041
Identities = 31/128 (24%), Positives = 58/128 (45%), Gaps = 2/128 (1%)
Query: 99 DTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRAN-A 157
DTAL LA ++ +L+ A ++ + G TPL +AA G +V+ +
Sbjct: 1089 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1148
Query: 158 AIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
A ++ TP+ LA G +++LL + A+ R T + +A+ G+ + +L
Sbjct: 1149 AQSERTKDTPLSLACSGGRQEVVDLLLAR-GANKEHRNVSDYTPLSLAASGGYVNIIKIL 1207
Query: 218 FKKGVYLH 225
G ++
Sbjct: 1208 LNAGAEIN 1215
Score = 39.9 bits (89), Expect = 0.096
Identities = 44/173 (25%), Positives = 71/173 (41%), Gaps = 9/173 (5%)
Query: 674 GHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG-GKQRET 732
G +++ LL + +V+ T L A V LL GADV+ R+T
Sbjct: 1268 GRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 1327
Query: 733 PLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLR 792
L IAA C L L+ GA + + G TP+ +A+ G+ + LL++ G D
Sbjct: 1328 ALTIAADKGHYKFCEL-LIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1386
Query: 793 KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDE 845
I TPL A R +V++L++ V + +I + +
Sbjct: 1387 ADNRKI-------TPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITD 1432
Score = 37.9 bits (84), Expect = 0.39
Identities = 28/111 (25%), Positives = 49/111 (44%), Gaps = 1/111 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
L AE H+ + L A + G V LL +G +N + G + L A AG
Sbjct: 204 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 263
Query: 1358 HLNVVKLLCESGASPKSETNL-NCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
+ + ++L A+ + N + P+ A+S + D+++ LL + D S
Sbjct: 264 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 314
>AK025859-1|BAB15260.1| 460|Homo sapiens protein ( Homo sapiens cDNA:
FLJ22206 fis, clone HRC01431. ).
Length = 460
Score = 146 bits (353), Expect = 1e-33
Identities = 114/368 (30%), Positives = 183/368 (49%), Gaps = 25/368 (6%)
Query: 1054 NIDA-TDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVI 1112
+IDA T+ + A + E+VQ L++ + + K G T +AA G V V+
Sbjct: 38 DIDAQTESNHDTALTLACAGGHEELVQTLLERGAS-IEHRDKKGFTPLILAATAGHVGVV 96
Query: 1113 EELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA 1172
E L+ I A+++ TPL LA GG +VV +L+ GA+ N + T + LA
Sbjct: 97 EILL--GNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLA 154
Query: 1173 AEHGHTNVLDVMRSTNTLRISSK---KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEA 1229
A G+ N++ ++ + I+S+ KLG++PL +AA G V+ LL + + ++
Sbjct: 155 ASGGYVNIIKILLNAGA-EINSRTGSKLGISPLMLAAMNGHTAAVKLLLD-MGSDINAQI 212
Query: 1230 PTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLN-SAGVQADAASNENGYNPLHLACF 1288
T + T L LA + G VV LLL+ A V+ A + G PL A
Sbjct: 213 ETNRN-----------TALTLACFQGRTEVVSLLLDRKANVEHRA---KTGLTPLMEAAS 258
Query: 1289 GGHMSIVGLLLSRSAEL-LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGW 1347
GG+ + +LL + A++ T L IA+ GHY+ E+L+G+GA I+ +K G
Sbjct: 259 GGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGN 318
Query: 1348 TPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
TPL AA GHL+VV+LL ++GA + N P+ A + H V+ YL+ + + S
Sbjct: 319 TPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPS 378
Query: 1408 LMDDKRFV 1415
+ R++
Sbjct: 379 DSECMRYI 386
Score = 128 bits (309), Expect = 2e-28
Identities = 97/293 (33%), Positives = 148/293 (50%), Gaps = 9/293 (3%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
T L +AC GH +LV TLL A ++ D +G + L LAA G++ V + LL N A I +
Sbjct: 49 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLGNGADIEA 108
Query: 991 KA-RNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL 1049
++ R T L LA G +V+ L+ A + + TPL LAA+ G + + K+LL
Sbjct: 109 QSERTKDTPLSLACSGGRQEVVELLLA-RGANKEHRNVSDYTPLSLAASGGYVNIIKILL 167
Query: 1050 ELGANIDAT--DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQG 1107
GA I++ +LG P+ AA N ++ V+L L ++ + NT +A QG
Sbjct: 168 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 227
Query: 1108 SVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGA--SCTDENRAG 1165
+V+ L+ DR + R K TPL AA GG+A+V RVL+ GA + +
Sbjct: 228 RTEVVSLLL--DRKANVEHRAK-TGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 284
Query: 1166 LTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
TA+ +AA+ GH +++ K G TPL +AA G + V+ L+
Sbjct: 285 DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 337
Score = 117 bits (281), Expect = 5e-25
Identities = 100/346 (28%), Positives = 163/346 (47%), Gaps = 15/346 (4%)
Query: 881 DVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRG 940
D+ QT NH+TA G+ +++ ++ ++ ++ G+TPL++A G
Sbjct: 38 DIDAQTESNHDTALTLACAGGHEELVQTLLER------GASIEHRDKKGFTPLILAATAG 91
Query: 941 HMQLVNTLLTNHARVDVFDVEGR-SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTAL 999
H+ +V LL N A ++ + + L LA G +V + LL A + + T L
Sbjct: 92 HVGVVEILLGNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL 151
Query: 1000 HLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQ--TPLHLAAASGQIEVCKLLLELGANIDA 1057
LAA GY +++K L+ + A I+ T K +PL LAA +G KLLL++G++I+A
Sbjct: 152 SLAASGGYVNIIKILL-NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINA 210
Query: 1058 TDELGQK-PIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
E + + A +EVV L L + N V K G T AA G +V L+
Sbjct: 211 QIETNRNTALTLACFQGRTEVVSLLLDRKAN-VEHRAKTGLTPLMEAASGGYAEVGRVLL 269
Query: 1117 KFDRTGVISARN-KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEH 1175
D+ ++A + T L +AA+ GH +L+ GA N+ G T + LAA
Sbjct: 270 --DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANG 327
Query: 1176 GHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
GH +V+ ++ ++ +TPL A G + VR L+ V
Sbjct: 328 GHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEV 373
Score = 92.3 bits (219), Expect = 2e-17
Identities = 88/337 (26%), Positives = 157/337 (46%), Gaps = 32/337 (9%)
Query: 750 LLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQ 809
LL+ GA + G TP+ +AA G++ + +LL +G D +++ T +TPL
Sbjct: 66 LLERGASIEHRDKKGFTPLILAATAGHVGVVEILLGNGADIEAQSER------TKDTPLS 119
Query: 810 MACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADR 869
+AC ++V L+ + + +VS D A++ Y
Sbjct: 120 LACSGGRQEVVELLLARGANKEHRNVS----DYTPLSLAASGGYV--------------- 160
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
++K L+ GA+++ +T + A + +++ + + D++ + +
Sbjct: 161 NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGS-DINAQIETNRN-- 217
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
T L +AC +G ++V+ LL A V+ G + L AA GY +V LL A +N
Sbjct: 218 -TALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 276
Query: 990 SKA--RNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKL 1047
+ + TAL +AA G+ + LI A IDV K TPL LAA G ++V +L
Sbjct: 277 APPVPSSRDTALTIAADKGHYKFCELLI-GRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 335
Query: 1048 LLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
L++ GA++DA D P+ AA + + +VV+ +++
Sbjct: 336 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 372
Score = 90.2 bits (214), Expect = 7e-17
Identities = 55/164 (33%), Positives = 86/164 (52%), Gaps = 2/164 (1%)
Query: 1269 VQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQM 1328
+ DA + N L LAC GGH +V LL R A + H D+ G T L +A+T GH +
Sbjct: 37 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHR-DKKGFTPLILAATAGHVGV 95
Query: 1329 VEVLLGQGAEINA-TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAA 1387
VE+LLG GA+I A +++ TPL A G VV+LL GA+ + + P+ AA
Sbjct: 96 VEILLGNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAA 155
Query: 1388 SENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIE 1431
S + ++++ LL+ + S K + LM+ + N + ++
Sbjct: 156 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVK 199
Score = 90.2 bits (214), Expect = 7e-17
Identities = 89/346 (25%), Positives = 153/346 (44%), Gaps = 29/346 (8%)
Query: 674 GHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETP 733
GH ++ TLL++G S++ +T L +A + VVE LLG GAD+ + + ++TP
Sbjct: 58 GHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLGNGADIEAQSERTKDTP 117
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L +A + +LL GA TP+ +AA G + + +LL G + +
Sbjct: 118 LSLACS-GGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR 176
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHY 853
T + G +PL +A + V+ L++ D + ++ + +AL
Sbjct: 177 TGSKL-----GISPLMLAAMNGHTAAVKLLLDMGSDINAQ---------IETNRNTALTL 222
Query: 854 ACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHI 913
AC + EV DR K +E+ A L E A A G V+ + A +
Sbjct: 223 ACFQGRTEVVSLLLDR---KANVEHRAKTGLTPLM--EAASGGYAEVGR--VLLDKGADV 275
Query: 914 STADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHG 973
+ V + + T L IA +GH + L+ A +DV + +G + L LAA G
Sbjct: 276 NAPPVPSSRD-------TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGG 328
Query: 974 YLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
+L V L+ A +++ T L A G+ +V++L+++ N
Sbjct: 329 HLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVN 374
Score = 72.1 bits (169), Expect = 2e-11
Identities = 102/383 (26%), Positives = 166/383 (43%), Gaps = 51/383 (13%)
Query: 608 PTPV--PTELLPIIWKPISKDSFYTLNIDTAMELKSGFFEDRMIFWDTFFEK---YKHFD 662
P+P+ P+ +LPI + I D+ N DTA+ L + ++ T E+ +H D
Sbjct: 21 PSPIISPSAMLPI-YPAIDIDAQTESNHDTALTLACAGGHEELV--QTLLERGASIEHRD 77
Query: 663 --GARSIHTAARYGHVGIINTLLQKGESVDV-TTNDNYTALHIAVESCKPAVVETLLGYG 719
G + AA GHVG++ LL G ++ + T L +A + VVE LL G
Sbjct: 78 KKGFTPLILAATAGHVGVVEILLGNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARG 137
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNL 777
A+ R TPL +AA +LL +GA N T G++P+ +AA G+
Sbjct: 138 ANKEHRNVSD-YTPLSLAAS-GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHT 195
Query: 778 ATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVK--DHKGESV 835
A + LLL+ G D + + T L +AC ++V L++ +H+ ++
Sbjct: 196 AAVKLLLDMGSDINAQIE------TNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTG 249
Query: 836 STAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSL-QTRHNHETAF 894
T ++A G A +V + L++ GADV+ + +TA
Sbjct: 250 LTPLMEAA--SGGYA-------------------EVGRVLLDKGADVNAPPVPSSRDTAL 288
Query: 895 HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
A G+ +I + DV +N G TPL +A + GH+ +V L+ A
Sbjct: 289 TIAADKGHYKFCELLIGRGAHIDV------RNKKGNTPLWLAANGGHLDVVQLLVQAGAD 342
Query: 955 VDVFDVEGRSALHLAAEHGYLQV 977
VD D + L A G+++V
Sbjct: 343 VDAADNRKITPLMAAFRKGHVKV 365
Score = 62.9 bits (146), Expect = 1e-08
Identities = 49/158 (31%), Positives = 78/158 (49%), Gaps = 6/158 (3%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G++ +V+ LL + ++ G T L LAA V + IL+ GA ++A
Sbjct: 51 LTLACAGGHEELVQTLL--ERGASIEHRDKKGFTPLILAATAGHVGVVEILLGNGADIEA 108
Query: 127 -TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ TPL +A + G + +V+ AN + D TP+ LAA G+ II++L +
Sbjct: 109 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 168
Query: 186 KFKASIFERT--KDGSTLMHIASLNGHADCAMMLFKKG 221
A I RT K G + + +A++NGH +L G
Sbjct: 169 A-GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 205
Score = 60.1 bits (139), Expect = 8e-08
Identities = 44/162 (27%), Positives = 75/162 (46%), Gaps = 3/162 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL+LA AG+ +V E+L A+ + DT L LA ++ +L+
Sbjct: 78 KKGFTPLILAATAGHVGVV-EILLGNGADIEAQSERTKDTPLSLACSGGRQEVVELLLAR 136
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPMHLAAENGHAA 178
GA + N + TPL +AA+ G ++K G N+ +P+ LAA NGH A
Sbjct: 137 GANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTA 196
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
++LL D + + +T + +A G + +L +
Sbjct: 197 AVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDR 238
Score = 60.1 bits (139), Expect = 8e-08
Identities = 37/121 (30%), Positives = 52/121 (42%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL+ A G + R LL + DTAL +AA + +L+ GA
Sbjct: 249 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGA 308
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+D N G TPL +AA G +V+ A+ ADN TP+ A GH ++
Sbjct: 309 HIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRY 368
Query: 183 L 183
L
Sbjct: 369 L 369
Score = 58.4 bits (135), Expect = 3e-07
Identities = 49/161 (30%), Positives = 76/161 (47%), Gaps = 4/161 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL+LA G+ + V+ LL + + T +TAL LA + ++ +L+D A
Sbjct: 182 GISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNR-NTALTLACFQGRTEVVSLLLDRKA 240
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPMHLAAENGHAAII 180
V+ G TPL AA+ G + + G NA + T + +AA+ GH
Sbjct: 241 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 300
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
ELL + A I R K G+T + +A+ GH D +L + G
Sbjct: 301 ELLIGR-GAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 340
Score = 52.8 bits (121), Expect = 1e-05
Identities = 44/168 (26%), Positives = 76/168 (45%), Gaps = 6/168 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G ++++ LL+A + + G + L LAA ++L+D G+ ++
Sbjct: 150 PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDIN 209
Query: 126 ATNGAGQ-TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A + T L +A +G +V +AN TP+ AA G+A + +L
Sbjct: 210 AQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 269
Query: 185 DK---FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
DK A ++D T + IA+ GH +L +G ++ + NK
Sbjct: 270 DKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIGRGAHIDVRNK 315
Score = 49.6 bits (113), Expect = 1e-04
Identities = 39/146 (26%), Positives = 69/146 (47%), Gaps = 3/146 (2%)
Query: 82 LLSAQTAEQLKATTPAG-DTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAA 140
+L A + A T + DTAL LA ++ + L++ GA ++ + G TPL +AA
Sbjct: 30 MLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAAT 89
Query: 141 EGDEPLVKYFYGVRAN-AAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGS 199
G +V+ G A+ A ++ TP+ LA G ++ELL + A+ R
Sbjct: 90 AGHVGVVEILLGNGADIEAQSERTKDTPLSLACSGGRQEVVELLLAR-GANKEHRNVSDY 148
Query: 200 TLMHIASLNGHADCAMMLFKKGVYLH 225
T + +A+ G+ + +L G ++
Sbjct: 149 TPLSLAASGGYVNIIKILLNAGAEIN 174
Score = 47.2 bits (107), Expect = 6e-04
Identities = 53/201 (26%), Positives = 83/201 (41%), Gaps = 13/201 (6%)
Query: 674 GHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG-GKQRET 732
G +++ LL + +V+ T L A V LL GADV+ R+T
Sbjct: 227 GRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 286
Query: 733 PLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLR 792
L IAA C L L+ GA + + G TP+ +AA G+L + LL++ G D
Sbjct: 287 ALTIAADKGHYKFCEL-LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA 345
Query: 793 KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALH 852
I TPL A R +VR+L++ V +S +I + + +
Sbjct: 346 ADNRKI-------TPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITD---KEML 395
Query: 853 YACKVTKEEVKIPTADRQVVK 873
C + E + + DRQ +
Sbjct: 396 KKCHLCMESI-VQAKDRQAAE 415
Score = 41.1 bits (92), Expect = 0.041
Identities = 35/115 (30%), Positives = 54/115 (46%), Gaps = 6/115 (5%)
Query: 111 VDMARILVDYGAV-VDA-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPM 168
+ + +L Y A+ +DA T T L +A A G E LV+ A+ D + TP+
Sbjct: 25 ISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPL 84
Query: 169 HLAAENGHAAIIELLADKFK--ASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LAA GH ++E+L + ERTKD T + +A G + +L +G
Sbjct: 85 ILAATAGHVGVVEILLGNGADIEAQSERTKD--TPLSLACSGGRQEVVELLLARG 137
>AY070436-1|AAL65263.1| 968|Homo sapiens hypothetical protein
protein.
Length = 968
Score = 144 bits (348), Expect = 4e-33
Identities = 123/430 (28%), Positives = 207/430 (48%), Gaps = 33/430 (7%)
Query: 1054 NIDA-TDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVI 1112
+IDA T+ + A + E+V + + + + K G T +AA G V V+
Sbjct: 540 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAK-IEHRDKKGFTPLILAATAGHVGVV 598
Query: 1113 EELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA 1172
E L+ D+ G I A+++ TPL LA GG +VV +L+ GA+ N + T + LA
Sbjct: 599 EILL--DKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 656
Query: 1173 AEHGHTNVLDVMRSTNTLRISSK---KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEA 1229
A G+ N++ ++ + I+S+ KLG++PL +AA G V+ LL + + ++
Sbjct: 657 ASGGYVNIIKILLNAGA-EINSRTGSKLGISPLMLAAMNGHVPAVKLLLD-MGSDINAQI 714
Query: 1230 PTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLN-SAGVQADAASNENGYNPLHLACF 1288
T + T L LA + G VV LLL+ A V+ A + G PL A
Sbjct: 715 ETNRN-----------TALTLACFQGRAEVVSLLLDRKANVEHRA---KTGLTPLMEAAS 760
Query: 1289 GGHMSIVGLLLSRSAEL-LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGW 1347
GG+ + +LL + A++ T L IA+ GHY+ E+L+ +GA I+ +K G
Sbjct: 761 GGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGN 820
Query: 1348 TPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
TPL A+ GH +VV+LL ++GA + N P+ A + H V++YL+ + + S
Sbjct: 821 TPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPS 880
Query: 1408 LMDDKRFVYNLM---VCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIY---INLSTKEKER 1461
++ R++ + + K H +E V A K ++I ++L +E
Sbjct: 881 DIECMRYIATITDKELLKKCHQ--CVETIVKAKDQQAAEANKNASILLKELDLEKSREES 938
Query: 1462 AKDLIAAGKQ 1471
K +AA ++
Sbjct: 939 RKQALAAKRE 948
Score = 120 bits (289), Expect = 6e-26
Identities = 92/293 (31%), Positives = 145/293 (49%), Gaps = 9/293 (3%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
T L +AC GH +LV+ L+ A+++ D +G + L LAA G++ V + LL I +
Sbjct: 551 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 610
Query: 991 KA-RNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL 1049
++ R T L LA G +V L+ A + + TPL LAA+ G + + K+LL
Sbjct: 611 QSERTKDTPLSLACSGGRQEVVDLLLA-RGANKEHRNVSDYTPLSLAASGGYVNIIKILL 669
Query: 1050 ELGANIDAT--DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQG 1107
GA I++ +LG P+ AA N + V+L L ++ + NT +A QG
Sbjct: 670 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 729
Query: 1108 SVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGA--SCTDENRAG 1165
+V+ L+ DR + R K TPL AA GG+A+V RVL+ GA + +
Sbjct: 730 RAEVVSLLL--DRKANVEHRAK-TGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 786
Query: 1166 LTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
TA+ +AA+ GH +++ K G TPL +A+ G + V+ L+
Sbjct: 787 DTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLV 839
Score = 114 bits (274), Expect = 4e-24
Identities = 98/346 (28%), Positives = 162/346 (46%), Gaps = 15/346 (4%)
Query: 881 DVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRG 940
D+ T NH+TA G+ ++++ +IA + ++ G+TPL++A G
Sbjct: 540 DIDAHTESNHDTALTLACAGGHEELVSVLIAR------DAKIEHRDKKGFTPLILAATAG 593
Query: 941 HMQLVNTLLTNHARVDVFDVEGR-SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTAL 999
H+ +V LL ++ + + L LA G +V D LL A + + T L
Sbjct: 594 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPL 653
Query: 1000 HLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQ--TPLHLAAASGQIEVCKLLLELGANIDA 1057
LAA GY +++K L+ + A I+ T K +PL LAA +G + KLLL++G++I+A
Sbjct: 654 SLAASGGYVNIIKILL-NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINA 712
Query: 1058 TDELGQK-PIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
E + + A +EVV L L + N V K G T AA G +V L+
Sbjct: 713 QIETNRNTALTLACFQGRAEVVSLLLDRKAN-VEHRAKTGLTPLMEAASGGYAEVGRVLL 771
Query: 1117 KFDRTGVISARN-KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEH 1175
D+ ++A + T L +AA+ GH +L+ GA N+ G T + LA+
Sbjct: 772 --DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNG 829
Query: 1176 GHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
GH +V+ ++ ++ +TPL A G + V+ L+ V
Sbjct: 830 GHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEV 875
Score = 90.6 bits (215), Expect = 5e-17
Identities = 66/226 (29%), Positives = 109/226 (48%), Gaps = 5/226 (2%)
Query: 1211 AETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQ 1270
A+T+ + L + V + PTG + LTP + N + V
Sbjct: 483 AQTLTDTLDDLIAAVSTRVPTGSNSSSQ--TTECLTPESCSQTTSNVASQSMPPVYPSVD 540
Query: 1271 ADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVE 1330
DA + N L LAC GGH +V +L++R A++ H D+ G T L +A+T GH +VE
Sbjct: 541 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEH-RDKKGFTPLILAATAGHVGVVE 599
Query: 1331 VLLGQGAEINA-TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASE 1389
+LL +G +I A +++ TPL A G VV LL GA+ + + P+ AAS
Sbjct: 600 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 659
Query: 1390 NHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVL 1435
+ ++++ LL+ + S K + LM+ + N ++P + +L
Sbjct: 660 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN-GHVPAVKLLL 704
Score = 87.0 bits (206), Expect = 6e-16
Identities = 84/323 (26%), Positives = 151/323 (46%), Gaps = 32/323 (9%)
Query: 764 GMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHL 823
G TP+ +AA G++ + +LL+ GGD +++ T +TPL +AC ++V L
Sbjct: 582 GFTPLILAATAGHVGVVEILLDKGGDIEAQSER------TKDTPLSLACSGGRQEVVDLL 635
Query: 824 IEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVS 883
+ + + +VS D A++ Y ++K L+ GA+++
Sbjct: 636 LARGANKEHRNVS----DYTPLSLAASGGYV---------------NIIKILLNAGAEIN 676
Query: 884 LQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQ 943
+T + A + +++ + + D++ + + T L +AC +G +
Sbjct: 677 SRTGSKLGISPLMLAAMNGHVPAVKLLLDMGS-DINAQIETNRN---TALTLACFQGRAE 732
Query: 944 LVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKA--RNGRTALHL 1001
+V+ LL A V+ G + L AA GY +V LL A +N+ + TAL +
Sbjct: 733 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 792
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
AA G+ + LI A IDV K TPL LA+ G +V +LL++ GA++DA D
Sbjct: 793 AADKGHYKFCELLIH-RGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 851
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQ 1084
P+ +A + + +VVQ +++
Sbjct: 852 KITPLMSAFRKGHVKVVQYLVKE 874
Score = 75.4 bits (177), Expect = 2e-12
Identities = 63/205 (30%), Positives = 97/205 (47%), Gaps = 29/205 (14%)
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTN 1188
+L STPL A++ GH ++V+ L+ +GA+ G TA+ A E+GHT+V DV+
Sbjct: 7 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL---- 62
Query: 1189 TLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPL 1248
L A + E ++ +L + E +E G TPL
Sbjct: 63 -------------LQAGADLDKQEDMKTILEGIDPAKHQEHE----------SEGGRTPL 99
Query: 1249 HLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHS 1308
AA G+ V+ L+ S G + A+ N + + LAC GGH+++V LLL+ A+ H
Sbjct: 100 MKAARAGHLCTVQFLI-SKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHR 158
Query: 1309 TDRHGKTGLHIASTHGHYQMVEVLL 1333
+ G T L A+ GH +V LL
Sbjct: 159 L-KDGSTMLIEAAKGGHTNVVSYLL 182
Score = 73.7 bits (173), Expect = 6e-12
Identities = 81/346 (23%), Positives = 147/346 (42%), Gaps = 29/346 (8%)
Query: 674 GHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETP 733
GH +++ L+ + ++ +T L +A + VVE LL G D+ + + ++TP
Sbjct: 560 GHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTP 619
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L +A + +LL GA TP+ +AA G + + +LL G + +
Sbjct: 620 LSLACS-GGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR 678
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHY 853
T + G +PL +A + V+ L++ D + ++ + +AL
Sbjct: 679 TGSKL-----GISPLMLAAMNGHVPAVKLLLDMGSDINAQ---------IETNRNTALTL 724
Query: 854 ACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHI 913
AC + EV DR K +E+ A L E A A G V+ + A +
Sbjct: 725 ACFQGRAEVVSLLLDR---KANVEHRAKTGLTPLM--EAASGGYAEVGR--VLLDKGADV 777
Query: 914 STADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHG 973
+ V + + T L IA +GH + L+ A +DV + +G + L LA+ G
Sbjct: 778 NAPPVPSSRD-------TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGG 830
Query: 974 YLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
+ V L+ A +++ T L A G+ +V++L+++ N
Sbjct: 831 HFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVN 876
Score = 70.5 bits (165), Expect = 6e-11
Identities = 98/381 (25%), Positives = 164/381 (43%), Gaps = 44/381 (11%)
Query: 611 VPTELLPIIWKPISKDSFYTLNIDTAMELK-SGFFEDRMIFWDTFFEKYKHFD--GARSI 667
V ++ +P ++ + D+ N DTA+ L +G E+ + K +H D G +
Sbjct: 527 VASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPL 586
Query: 668 HTAARYGHVGIINTLLQKGESVDV-TTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
AA GHVG++ LL KG ++ + T L +A + VV+ LL GA+ R
Sbjct: 587 ILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRN 646
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNLATLVLLL 784
TPL +AA +LL +GA N T G++P+ +AA G++ + LLL
Sbjct: 647 VSD-YTPLSLAAS-GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 704
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVK--DHKGESVSTAFIDA 842
+ G D + + T L +AC ++V L++ +H+ ++ T ++A
Sbjct: 705 DMGSDINAQIE------TNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEA 758
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSL-QTRHNHETAFHYCAIAG 901
G A +V + L++ GADV+ + +TA A G
Sbjct: 759 A--SGGYA-------------------EVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 797
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ +I + DV +N G TPL +A + GH +V L+ A VD D
Sbjct: 798 HYKFCELLIHRGAHIDV------RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 851
Query: 962 GRSALHLAAEHGYLQVCDALL 982
+ L A G+++V L+
Sbjct: 852 KITPLMSAFRKGHVKVVQYLV 872
Score = 65.3 bits (152), Expect = 2e-09
Identities = 58/183 (31%), Positives = 82/183 (44%), Gaps = 23/183 (12%)
Query: 1246 TPLHLAAYNGNENVVRLLLNS-AGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAE 1304
TPL A+ G+ +V+ LL S A V A A+ + L AC GH + +LL A+
Sbjct: 12 TPLMEASQEGHLELVKYLLASGANVHATTATGDTA---LTYACENGHTDVADVLLQAGAD 68
Query: 1305 LLHSTD-----------RH-------GKTGLHIASTHGHYQMVEVLLGQGAEIN-ATDKN 1345
L D +H G+T L A+ GH V+ L+ +GA +N AT N
Sbjct: 69 LDKQEDMKTILEGIDPAKHQEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN 128
Query: 1346 GWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
T + A GHL VV+LL GA P + AA H +V+ YLL ++
Sbjct: 129 DHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 188
Query: 1406 QSL 1408
S+
Sbjct: 189 LSV 191
Score = 63.3 bits (147), Expect = 9e-09
Identities = 54/174 (31%), Positives = 80/174 (45%), Gaps = 8/174 (4%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP-----LHLAA-Y 1253
TPL A+ G E V+ LL+ V + TG + + E+G T L A
Sbjct: 12 TPLMEASQEGHLELVKYLLAS-GANVHATTATGDTAL-TYACENGHTDVADVLLQAGADL 69
Query: 1254 NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHG 1313
+ E++ +L + +E G PL A GH+ V L+S+ A + +T +
Sbjct: 70 DKQEDMKTILEGIDPAKHQEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANND 129
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
T + +A GH +VE+LL GA+ K+G T L AAK GH NVV L +
Sbjct: 130 HTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 183
Score = 63.3 bits (147), Expect = 9e-09
Identities = 56/173 (32%), Positives = 79/173 (45%), Gaps = 25/173 (14%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL+ A + G+ +V+ LL++ + ATT GDTAL A D+A +L+ GA +D
Sbjct: 13 PLMEASQEGHLELVKYLLAS--GANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 70
Query: 126 ATNG-------------------AGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNED 164
G+TPL AA G V++ G N A A+N D
Sbjct: 71 KQEDMKTILEGIDPAKHQEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN-D 129
Query: 165 RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
T + LA GH A++ELL A R KDGST++ A+ GH + L
Sbjct: 130 HTVVSLACAGGHLAVVELLL-AHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 181
Score = 62.1 bits (144), Expect = 2e-08
Identities = 48/158 (30%), Positives = 77/158 (48%), Gaps = 6/158 (3%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G++ +V L++ +++ G T L LAA V + IL+D G ++A
Sbjct: 553 LTLACAGGHEELVSVLIARDA--KIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 610
Query: 127 -TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ TPL +A + G + +V AN + D TP+ LAA G+ II++L +
Sbjct: 611 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 670
Query: 186 KFKASIFERT--KDGSTLMHIASLNGHADCAMMLFKKG 221
A I RT K G + + +A++NGH +L G
Sbjct: 671 A-GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG 707
Score = 61.3 bits (142), Expect = 4e-08
Identities = 54/184 (29%), Positives = 79/184 (42%), Gaps = 19/184 (10%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL+ A GH++LV LL + A V G +AL A E+G+ V D LL A ++
Sbjct: 12 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDK 71
Query: 991 -------------------KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQT 1031
++ GRT L AA G+ V+FLI + T
Sbjct: 72 QEDMKTILEGIDPAKHQEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 131
Query: 1032 PLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
+ LA A G + V +LLL GA+ + G + AA+ ++ VV L N++
Sbjct: 132 VVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSV 191
Query: 1092 TTKD 1095
T D
Sbjct: 192 PTTD 195
Score = 59.7 bits (138), Expect = 1e-07
Identities = 64/222 (28%), Positives = 93/222 (41%), Gaps = 28/222 (12%)
Query: 1031 TPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVM 1090
TPL A+ G +E+ K LL GAN+ AT G + A +N +++V + LQ +L
Sbjct: 12 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDK 71
Query: 1091 ATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDS----TPLQLAAEGGHAD 1146
Q +K I E G+ A+++ ++S TPL AA GH
Sbjct: 72 ---------------QEDMKTILE-------GIDPAKHQEHESEGGRTPLMKAARAGHLC 109
Query: 1147 VVRVLVRAGASCTDEN-RAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIA 1205
V+ L+ GA+ T V LA GH V++++ + K G T L A
Sbjct: 110 TVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 169
Query: 1206 AYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
A G V LL + P V S T VS +P + P
Sbjct: 170 AKGGHTNVVSYLLDY-PNNVLSVPTTDVSQLPPPSQDQSQVP 210
Score = 59.3 bits (137), Expect = 1e-07
Identities = 36/121 (29%), Positives = 53/121 (43%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL+ A G + R LL + DTAL +AA + +L+ GA
Sbjct: 751 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGA 810
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+D N G TPL +A+ G +V+ A+ ADN TP+ A GH +++
Sbjct: 811 HIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQY 870
Query: 183 L 183
L
Sbjct: 871 L 871
Score = 58.0 bits (134), Expect = 3e-07
Identities = 50/161 (31%), Positives = 75/161 (46%), Gaps = 4/161 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL+LA G+ V+ LL + + T +TAL LA + ++ +L+D A
Sbjct: 684 GISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR-NTALTLACFQGRAEVVSLLLDRKA 742
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPMHLAAENGHAAII 180
V+ G TPL AA+ G + + G NA + T + +AA+ GH
Sbjct: 743 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 802
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
ELL + A I R K G+T + +AS GH D +L + G
Sbjct: 803 ELLIHR-GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAG 842
Score = 56.8 bits (131), Expect = 8e-07
Identities = 43/162 (26%), Positives = 75/162 (46%), Gaps = 3/162 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL+LA AG+ +V E+L + + + DT L LA ++ +L+
Sbjct: 580 KKGFTPLILAATAGHVGVV-EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLAR 638
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPMHLAAENGHAA 178
GA + N + TPL +AA+ G ++K G N+ +P+ LAA NGH
Sbjct: 639 GANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVP 698
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
++LL D + + +T + +A G A+ +L +
Sbjct: 699 AVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDR 740
Score = 55.2 bits (127), Expect = 2e-06
Identities = 45/168 (26%), Positives = 77/168 (45%), Gaps = 6/168 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G ++++ LL+A + + G + L LAA V ++L+D G+ ++
Sbjct: 652 PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDIN 711
Query: 126 ATNGAGQ-TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A + T L +A +G +V +AN TP+ AA G+A + +L
Sbjct: 712 AQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 771
Query: 185 DK---FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
DK A ++D T + IA+ GH +L +G ++ + NK
Sbjct: 772 DKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIHRGAHIDVRNK 817
Score = 54.0 bits (124), Expect = 5e-06
Identities = 56/177 (31%), Positives = 81/177 (45%), Gaps = 29/177 (16%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVH------ 723
A++ GH+ ++ LL G +V TT TAL A E+ V + LL GAD+
Sbjct: 17 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 76
Query: 724 -----IRGGKQRE-------TPLHIAARIPDGDKCAL-MLLKSGAGPNKAT-EDGMTPVH 769
I K +E TPL AAR G C + L+ GA N+AT + T V
Sbjct: 77 TILEGIDPAKHQEHESEGGRTPLMKAARA--GHLCTVQFLISKGANVNRATANNDHTVVS 134
Query: 770 VAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
+A G+LA + LLL G DP + K G T L A + ++V +L+++
Sbjct: 135 LACAGGHLAVVELLLAHGADPTHRLK-------DGSTMLIEAAKGGHTNVVSYLLDY 184
Score = 53.2 bits (122), Expect = 1e-05
Identities = 50/168 (29%), Positives = 73/168 (43%), Gaps = 24/168 (14%)
Query: 1282 PLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINA 1341
PL A GH+ +V LL+ A + H+T G T L A +GH + +VLL GA+++
Sbjct: 13 PLMEASQEGHLELVKYLLASGANV-HATTATGDTALTYACENGHTDVADVLLQAGADLDK 71
Query: 1342 TD-------------------KNGWTPLHCAAKAGHLNVVKLLCESGASPKSET-NLNCA 1381
+ + G TPL AA+AGHL V+ L GA+ T N +
Sbjct: 72 QEDMKTILEGIDPAKHQEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 131
Query: 1382 PIWFAASENHNDVLEYLL-HKEHDTQSLMDDKRFVYNLMVCSKNHNNI 1428
+ A + H V+E LL H T L D + + H N+
Sbjct: 132 VVSLACAGGHLAVVELLLAHGADPTHRLKDGSTML--IEAAKGGHTNV 177
Score = 51.2 bits (117), Expect = 4e-05
Identities = 45/171 (26%), Positives = 78/171 (45%), Gaps = 15/171 (8%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDV-------------MTEMIAHISTA 916
++VK L+ +GA+V T +TA Y G+ DV +M +
Sbjct: 24 ELVKYLLASGANVHATTATG-DTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGI 82
Query: 917 DVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG-RSALHLAAEHGYL 975
D ++ ++ G TPL+ A GH+ V L++ A V+ + + LA G+L
Sbjct: 83 DPAKHQEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHL 142
Query: 976 QVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
V + LL + A + ++G T L AA G+ ++V +L+ N ++ V T
Sbjct: 143 AVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPT 193
Score = 44.8 bits (101), Expect = 0.003
Identities = 34/101 (33%), Positives = 47/101 (46%), Gaps = 5/101 (4%)
Query: 124 VDA-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+DA T T L +A A G E LV A D + TP+ LAA GH ++E+
Sbjct: 541 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 600
Query: 183 LADKFK--ASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L DK + ERTKD T + +A G + +L +G
Sbjct: 601 LLDKGGDIEAQSERTKD--TPLSLACSGGRQEVVDLLLARG 639
Score = 42.7 bits (96), Expect = 0.014
Identities = 23/67 (34%), Positives = 39/67 (58%), Gaps = 1/67 (1%)
Query: 656 EKYKHFDGARSIHTAARYGHVGIINTLLQKGESVD-VTTNDNYTALHIAVESCKPAVVET 714
++++ G + AAR GH+ + L+ KG +V+ T N+++T + +A AVVE
Sbjct: 88 QEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVEL 147
Query: 715 LLGYGAD 721
LL +GAD
Sbjct: 148 LLAHGAD 154
Score = 41.1 bits (92), Expect = 0.041
Identities = 31/128 (24%), Positives = 58/128 (45%), Gaps = 2/128 (1%)
Query: 99 DTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRAN-A 157
DTAL LA ++ +L+ A ++ + G TPL +AA G +V+ +
Sbjct: 550 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 609
Query: 158 AIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
A ++ TP+ LA G +++LL + A+ R T + +A+ G+ + +L
Sbjct: 610 AQSERTKDTPLSLACSGGRQEVVDLLLAR-GANKEHRNVSDYTPLSLAASGGYVNIIKIL 668
Query: 218 FKKGVYLH 225
G ++
Sbjct: 669 LNAGAEIN 676
Score = 40.7 bits (91), Expect = 0.055
Identities = 23/65 (35%), Positives = 31/65 (47%)
Query: 1348 TPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
TPL A++ GHL +VK L SGA+ + T + +A H DV + LL D
Sbjct: 12 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDK 71
Query: 1408 LMDDK 1412
D K
Sbjct: 72 QEDMK 76
Score = 39.9 bits (89), Expect = 0.096
Identities = 44/173 (25%), Positives = 71/173 (41%), Gaps = 9/173 (5%)
Query: 674 GHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG-GKQRET 732
G +++ LL + +V+ T L A V LL GADV+ R+T
Sbjct: 729 GRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 788
Query: 733 PLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLR 792
L IAA C L L+ GA + + G TP+ +A+ G+ + LL++ G D
Sbjct: 789 ALTIAADKGHYKFCEL-LIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 847
Query: 793 KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDE 845
I TPL A R +V++L++ V + +I + +
Sbjct: 848 ADNRKI-------TPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITD 893
Score = 38.7 bits (86), Expect = 0.22
Identities = 48/188 (25%), Positives = 77/188 (40%), Gaps = 21/188 (11%)
Query: 766 TPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIE 825
TP+ A++ G+L + LL G + T TG+T L AC + D+ L++
Sbjct: 12 TPLMEASQEGHLELVKYLLASGANVHATT-------ATGDTALTYACENGHTDVADVLLQ 64
Query: 826 FVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQ----VVKCLIENGAD 881
D + ++ +D A H + + A R V+ LI GA+
Sbjct: 65 AGADLDKQEDMKTILEGID----PAKHQEHESEGGRTPLMKAARAGHLCTVQFLISKGAN 120
Query: 882 VSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGH 941
V+ T +N T G+ V+ ++AH AD + L G T L+ A GH
Sbjct: 121 VNRATANNDHTVVSLACAGGHLAVVELLLAH--GADPTHRLKD----GSTMLIEAAKGGH 174
Query: 942 MQLVNTLL 949
+V+ LL
Sbjct: 175 TNVVSYLL 182
Score = 34.7 bits (76), Expect = 3.6
Identities = 19/59 (32%), Positives = 30/59 (50%), Gaps = 1/59 (1%)
Query: 166 TPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
TP+ A++ GH +++ L A++ T G T + A NGH D A +L + G L
Sbjct: 12 TPLMEASQEGHLELVKYLLAS-GANVHATTATGDTALTYACENGHTDVADVLLQAGADL 69
Score = 34.3 bits (75), Expect = 4.8
Identities = 19/51 (37%), Positives = 24/51 (47%)
Query: 133 TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
TPL A+ EG LVKY AN T + A ENGH + ++L
Sbjct: 12 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 62
>AF217646-1|AAG41779.1| 532|Homo sapiens hypothetical protein
protein.
Length = 532
Score = 144 bits (348), Expect = 4e-33
Identities = 123/430 (28%), Positives = 207/430 (48%), Gaps = 33/430 (7%)
Query: 1054 NIDA-TDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVI 1112
+IDA T+ + A + E+V + + + + K G T +AA G V V+
Sbjct: 123 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAK-IEHRDKKGFTPLILAATAGHVGVV 181
Query: 1113 EELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA 1172
E L+ D+ G I A+++ TPL LA GG +VV +L+ GA+ N + T + LA
Sbjct: 182 EILL--DKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 239
Query: 1173 AEHGHTNVLDVMRSTNTLRISSK---KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEA 1229
A G+ N++ ++ + I+S+ KLG++PL +AA G V+ LL + + ++
Sbjct: 240 ASGGYVNIIKILLNAGA-EINSRTGSKLGISPLMLAAMNGHVPAVKLLLD-MGSDINAQI 297
Query: 1230 PTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLN-SAGVQADAASNENGYNPLHLACF 1288
T + T L LA + G VV LLL+ A V+ A + G PL A
Sbjct: 298 ETNRN-----------TALTLACFQGRAEVVSLLLDRKANVEHRA---KTGLTPLMEAAS 343
Query: 1289 GGHMSIVGLLLSRSAEL-LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGW 1347
GG+ + +LL + A++ T L IA+ GHY+ E+L+ +GA I+ +K G
Sbjct: 344 GGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGN 403
Query: 1348 TPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
TPL A+ GH +VV+LL ++GA + N P+ A + H V++YL+ + + S
Sbjct: 404 TPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPS 463
Query: 1408 LMDDKRFVYNLM---VCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIY---INLSTKEKER 1461
++ R++ + + K H +E V A K ++I ++L +E
Sbjct: 464 DIECMRYIATITDKELLKKCHQ--CVETIVKAKDQQAAEANKNASILLKELDLEKSREES 521
Query: 1462 AKDLIAAGKQ 1471
K +AA ++
Sbjct: 522 RKQALAAKRE 531
Score = 120 bits (289), Expect = 6e-26
Identities = 92/293 (31%), Positives = 145/293 (49%), Gaps = 9/293 (3%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
T L +AC GH +LV+ L+ A+++ D +G + L LAA G++ V + LL I +
Sbjct: 134 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 193
Query: 991 KA-RNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL 1049
++ R T L LA G +V L+ A + + TPL LAA+ G + + K+LL
Sbjct: 194 QSERTKDTPLSLACSGGRQEVVDLLLA-RGANKEHRNVSDYTPLSLAASGGYVNIIKILL 252
Query: 1050 ELGANIDAT--DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQG 1107
GA I++ +LG P+ AA N + V+L L ++ + NT +A QG
Sbjct: 253 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 312
Query: 1108 SVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGA--SCTDENRAG 1165
+V+ L+ DR + R K TPL AA GG+A+V RVL+ GA + +
Sbjct: 313 RAEVVSLLL--DRKANVEHRAK-TGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 369
Query: 1166 LTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
TA+ +AA+ GH +++ K G TPL +A+ G + V+ L+
Sbjct: 370 DTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLV 422
Score = 114 bits (274), Expect = 4e-24
Identities = 98/346 (28%), Positives = 162/346 (46%), Gaps = 15/346 (4%)
Query: 881 DVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRG 940
D+ T NH+TA G+ ++++ +IA + ++ G+TPL++A G
Sbjct: 123 DIDAHTESNHDTALTLACAGGHEELVSVLIAR------DAKIEHRDKKGFTPLILAATAG 176
Query: 941 HMQLVNTLLTNHARVDVFDVEGR-SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTAL 999
H+ +V LL ++ + + L LA G +V D LL A + + T L
Sbjct: 177 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPL 236
Query: 1000 HLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQ--TPLHLAAASGQIEVCKLLLELGANIDA 1057
LAA GY +++K L+ + A I+ T K +PL LAA +G + KLLL++G++I+A
Sbjct: 237 SLAASGGYVNIIKILL-NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINA 295
Query: 1058 TDELGQK-PIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
E + + A +EVV L L + N V K G T AA G +V L+
Sbjct: 296 QIETNRNTALTLACFQGRAEVVSLLLDRKAN-VEHRAKTGLTPLMEAASGGYAEVGRVLL 354
Query: 1117 KFDRTGVISARN-KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEH 1175
D+ ++A + T L +AA+ GH +L+ GA N+ G T + LA+
Sbjct: 355 --DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNG 412
Query: 1176 GHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
GH +V+ ++ ++ +TPL A G + V+ L+ V
Sbjct: 413 GHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEV 458
Score = 90.6 bits (215), Expect = 5e-17
Identities = 66/226 (29%), Positives = 109/226 (48%), Gaps = 5/226 (2%)
Query: 1211 AETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQ 1270
A+T+ + L + V + PTG + LTP + N + V
Sbjct: 66 AQTLTDTLDDLIAAVSTRVPTGSNSSSQ--TTECLTPESCSQTTSNVASQSMPPVYPSVD 123
Query: 1271 ADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVE 1330
DA + N L LAC GGH +V +L++R A++ H D+ G T L +A+T GH +VE
Sbjct: 124 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEH-RDKKGFTPLILAATAGHVGVVE 182
Query: 1331 VLLGQGAEINA-TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASE 1389
+LL +G +I A +++ TPL A G VV LL GA+ + + P+ AAS
Sbjct: 183 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 242
Query: 1390 NHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVL 1435
+ ++++ LL+ + S K + LM+ + N ++P + +L
Sbjct: 243 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN-GHVPAVKLLL 287
Score = 87.0 bits (206), Expect = 6e-16
Identities = 84/323 (26%), Positives = 151/323 (46%), Gaps = 32/323 (9%)
Query: 764 GMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHL 823
G TP+ +AA G++ + +LL+ GGD +++ T +TPL +AC ++V L
Sbjct: 165 GFTPLILAATAGHVGVVEILLDKGGDIEAQSER------TKDTPLSLACSGGRQEVVDLL 218
Query: 824 IEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVS 883
+ + + +VS D A++ Y ++K L+ GA+++
Sbjct: 219 LARGANKEHRNVS----DYTPLSLAASGGYV---------------NIIKILLNAGAEIN 259
Query: 884 LQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQ 943
+T + A + +++ + + D++ + + T L +AC +G +
Sbjct: 260 SRTGSKLGISPLMLAAMNGHVPAVKLLLDMGS-DINAQIETNRN---TALTLACFQGRAE 315
Query: 944 LVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKA--RNGRTALHL 1001
+V+ LL A V+ G + L AA GY +V LL A +N+ + TAL +
Sbjct: 316 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 375
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
AA G+ + LI A IDV K TPL LA+ G +V +LL++ GA++DA D
Sbjct: 376 AADKGHYKFCELLIH-RGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 434
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQ 1084
P+ +A + + +VVQ +++
Sbjct: 435 KITPLMSAFRKGHVKVVQYLVKE 457
Score = 73.7 bits (173), Expect = 6e-12
Identities = 81/346 (23%), Positives = 147/346 (42%), Gaps = 29/346 (8%)
Query: 674 GHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETP 733
GH +++ L+ + ++ +T L +A + VVE LL G D+ + + ++TP
Sbjct: 143 GHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTP 202
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L +A + +LL GA TP+ +AA G + + +LL G + +
Sbjct: 203 LSLACS-GGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR 261
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHY 853
T + G +PL +A + V+ L++ D + ++ + +AL
Sbjct: 262 TGSKL-----GISPLMLAAMNGHVPAVKLLLDMGSDINAQ---------IETNRNTALTL 307
Query: 854 ACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHI 913
AC + EV DR K +E+ A L E A A G V+ + A +
Sbjct: 308 ACFQGRAEVVSLLLDR---KANVEHRAKTGLTPLM--EAASGGYAEVGR--VLLDKGADV 360
Query: 914 STADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHG 973
+ V + + T L IA +GH + L+ A +DV + +G + L LA+ G
Sbjct: 361 NAPPVPSSRD-------TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGG 413
Query: 974 YLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
+ V L+ A +++ T L A G+ +V++L+++ N
Sbjct: 414 HFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVN 459
Score = 70.5 bits (165), Expect = 6e-11
Identities = 98/381 (25%), Positives = 164/381 (43%), Gaps = 44/381 (11%)
Query: 611 VPTELLPIIWKPISKDSFYTLNIDTAMELK-SGFFEDRMIFWDTFFEKYKHFD--GARSI 667
V ++ +P ++ + D+ N DTA+ L +G E+ + K +H D G +
Sbjct: 110 VASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPL 169
Query: 668 HTAARYGHVGIINTLLQKGESVDV-TTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
AA GHVG++ LL KG ++ + T L +A + VV+ LL GA+ R
Sbjct: 170 ILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRN 229
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNLATLVLLL 784
TPL +AA +LL +GA N T G++P+ +AA G++ + LLL
Sbjct: 230 VSD-YTPLSLAAS-GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 287
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVK--DHKGESVSTAFIDA 842
+ G D + + T L +AC ++V L++ +H+ ++ T ++A
Sbjct: 288 DMGSDINAQIE------TNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEA 341
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSL-QTRHNHETAFHYCAIAG 901
G A +V + L++ GADV+ + +TA A G
Sbjct: 342 A--SGGYA-------------------EVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 380
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ +I + DV +N G TPL +A + GH +V L+ A VD D
Sbjct: 381 HYKFCELLIHRGAHIDV------RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 434
Query: 962 GRSALHLAAEHGYLQVCDALL 982
+ L A G+++V L+
Sbjct: 435 KITPLMSAFRKGHVKVVQYLV 455
Score = 62.1 bits (144), Expect = 2e-08
Identities = 48/158 (30%), Positives = 77/158 (48%), Gaps = 6/158 (3%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G++ +V L++ +++ G T L LAA V + IL+D G ++A
Sbjct: 136 LTLACAGGHEELVSVLIARDA--KIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 193
Query: 127 -TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ TPL +A + G + +V AN + D TP+ LAA G+ II++L +
Sbjct: 194 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 253
Query: 186 KFKASIFERT--KDGSTLMHIASLNGHADCAMMLFKKG 221
A I RT K G + + +A++NGH +L G
Sbjct: 254 A-GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG 290
Score = 59.3 bits (137), Expect = 1e-07
Identities = 36/121 (29%), Positives = 53/121 (43%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL+ A G + R LL + DTAL +AA + +L+ GA
Sbjct: 334 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGA 393
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+D N G TPL +A+ G +V+ A+ ADN TP+ A GH +++
Sbjct: 394 HIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQY 453
Query: 183 L 183
L
Sbjct: 454 L 454
Score = 58.0 bits (134), Expect = 3e-07
Identities = 50/161 (31%), Positives = 75/161 (46%), Gaps = 4/161 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL+LA G+ V+ LL + + T +TAL LA + ++ +L+D A
Sbjct: 267 GISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR-NTALTLACFQGRAEVVSLLLDRKA 325
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPMHLAAENGHAAII 180
V+ G TPL AA+ G + + G NA + T + +AA+ GH
Sbjct: 326 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 385
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
ELL + A I R K G+T + +AS GH D +L + G
Sbjct: 386 ELLIHR-GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAG 425
Score = 56.8 bits (131), Expect = 8e-07
Identities = 43/162 (26%), Positives = 75/162 (46%), Gaps = 3/162 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G PL+LA AG+ +V E+L + + + DT L LA ++ +L+
Sbjct: 163 KKGFTPLILAATAGHVGVV-EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLAR 221
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIADNEDRTPMHLAAENGHAA 178
GA + N + TPL +AA+ G ++K G N+ +P+ LAA NGH
Sbjct: 222 GANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVP 281
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
++LL D + + +T + +A G A+ +L +
Sbjct: 282 AVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDR 323
Score = 55.2 bits (127), Expect = 2e-06
Identities = 45/168 (26%), Positives = 77/168 (45%), Gaps = 6/168 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G ++++ LL+A + + G + L LAA V ++L+D G+ ++
Sbjct: 235 PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDIN 294
Query: 126 ATNGAGQ-TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A + T L +A +G +V +AN TP+ AA G+A + +L
Sbjct: 295 AQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 354
Query: 185 DK---FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
DK A ++D T + IA+ GH +L +G ++ + NK
Sbjct: 355 DKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIHRGAHIDVRNK 400
Score = 44.8 bits (101), Expect = 0.003
Identities = 34/101 (33%), Positives = 47/101 (46%), Gaps = 5/101 (4%)
Query: 124 VDA-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+DA T T L +A A G E LV A D + TP+ LAA GH ++E+
Sbjct: 124 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 183
Query: 183 LADKFK--ASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L DK + ERTKD T + +A G + +L +G
Sbjct: 184 LLDKGGDIEAQSERTKD--TPLSLACSGGRQEVVDLLLARG 222
Score = 41.1 bits (92), Expect = 0.041
Identities = 31/128 (24%), Positives = 58/128 (45%), Gaps = 2/128 (1%)
Query: 99 DTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRAN-A 157
DTAL LA ++ +L+ A ++ + G TPL +AA G +V+ +
Sbjct: 133 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 192
Query: 158 AIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
A ++ TP+ LA G +++LL + A+ R T + +A+ G+ + +L
Sbjct: 193 AQSERTKDTPLSLACSGGRQEVVDLLLAR-GANKEHRNVSDYTPLSLAASGGYVNIIKIL 251
Query: 218 FKKGVYLH 225
G ++
Sbjct: 252 LNAGAEIN 259
Score = 39.9 bits (89), Expect = 0.096
Identities = 44/173 (25%), Positives = 71/173 (41%), Gaps = 9/173 (5%)
Query: 674 GHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG-GKQRET 732
G +++ LL + +V+ T L A V LL GADV+ R+T
Sbjct: 312 GRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 371
Query: 733 PLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLR 792
L IAA C L L+ GA + + G TP+ +A+ G+ + LL++ G D
Sbjct: 372 ALTIAADKGHYKFCEL-LIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 430
Query: 793 KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDE 845
I TPL A R +V++L++ V + +I + +
Sbjct: 431 ADNRKI-------TPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITD 476
>DQ436495-1|ABD96827.1| 1430|Homo sapiens death-associated protein
kinase 1 protein.
Length = 1430
Score = 139 bits (337), Expect = 9e-32
Identities = 87/283 (30%), Positives = 150/283 (53%), Gaps = 8/283 (2%)
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
ND + H+ + + +N+ N G PLLIA G++Q++ L+ +R+DV D G
Sbjct: 353 NDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGG 412
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+A++ AA HG++ L NK ++ K ++G ALH+AA G+A + + L+ +
Sbjct: 413 SNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQ-LLCSFGSNP 471
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
++ +++TPLH AA G V K L E G N++ + G+ P+ A+ Y ++V+ L
Sbjct: 472 NIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVEC-L 530
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
+H + A KDG+ H+A + ++VI+ L+ G + +TPL +A +
Sbjct: 531 AEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLS---QGCFVDYQDRHGNTPLHVACKD 587
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMR 1185
G+ +V L A + N+ G T +HLAA +G +LDV+R
Sbjct: 588 GNMPIVVALCEANCNLDISNKYGRTPLHLAANNG---ILDVVR 627
Score = 121 bits (291), Expect = 3e-26
Identities = 89/306 (29%), Positives = 148/306 (48%), Gaps = 20/306 (6%)
Query: 1124 ISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDV 1183
++ NK + + PL +AA G+ ++++L++ G+ +++ G AV+ AA HGH + L
Sbjct: 372 VNQPNK-HGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKF 430
Query: 1184 MRSTNTLRISSK-KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAE 1242
+ S N + K K G LH+AA YG A+ + L S P + +
Sbjct: 431 L-SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSN-------------PNIQDK 476
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRS 1302
TPLH AA++G +V + L AG + N G PL A G+ IV L
Sbjct: 477 EEETPLHCAAWHGYYSVAKALCE-AGCNVNI-KNREGETPLLTASARGYHDIVECLAEHG 534
Query: 1303 AELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVV 1362
A+L ++ D+ G LH+A ++++ LL QG ++ D++G TPLH A K G++ +V
Sbjct: 535 ADL-NACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIV 593
Query: 1363 KLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCS 1422
LCE+ + P+ AA+ DV+ YL ++L D + +L S
Sbjct: 594 VALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDL-ARS 652
Query: 1423 KNHNNI 1428
+ H ++
Sbjct: 653 EQHEHV 658
Score = 117 bits (282), Expect = 4e-25
Identities = 104/352 (29%), Positives = 158/352 (44%), Gaps = 20/352 (5%)
Query: 1055 IDATDELGQKPI-HAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIE 1113
+D D K I HA +N + L V K G IAA G++++++
Sbjct: 337 LDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQ 396
Query: 1114 ELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAA 1173
L+K R I ++K S + AA GH D ++ L ++++G A+H+AA
Sbjct: 397 LLIK--RGSRIDVQDK-GGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAA 453
Query: 1174 EHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGV 1233
+GH +V ++ S + K TPLH AA++G + L EA V
Sbjct: 454 RYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALC---------EAGCNV 504
Query: 1234 SLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMS 1293
++ G TPL A+ G ++V L G +A +++G+ LHLA M
Sbjct: 505 NIKN----REGETPLLTASARGYHDIVECLAEH-GADLNAC-DKDGHIALHLAVRRCQME 558
Query: 1294 IVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCA 1353
++ LLS+ + DRHG T LH+A G+ +V L ++ ++K G TPLH A
Sbjct: 559 VIKTLLSQGC-FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLA 617
Query: 1354 AKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
A G L+VV+ LC GAS ++ T A SE H V L DT
Sbjct: 618 ANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDT 669
Score = 96.7 bits (230), Expect = 8e-19
Identities = 87/323 (26%), Positives = 146/323 (45%), Gaps = 34/323 (10%)
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMP 817
N+ + G P+ +AA GN+ L LL++ G +++ + D G + A R
Sbjct: 373 NQPNKHGTPPLLIAAGCGNIQILQLLIKRG------SRIDVQDK-GGSNAVYWAARHGHV 425
Query: 818 DIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIE 877
D ++ L E + +D D+ G ALH A + +V + L
Sbjct: 426 DTLKFLSE----------NKCPLDVKDKSGEMALHVAARYGHADV---------AQLLCS 466
Query: 878 NGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIAC 937
G++ ++Q + ET H A G V + + +N +N G TPLL A
Sbjct: 467 FGSNPNIQDKEE-ETPLHCAAWHGYYSVAKAL------CEAGCNVNIKNREGETPLLTAS 519
Query: 938 HRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRT 997
RG+ +V L + A ++ D +G ALHLA ++V LL+ F++ + R+G T
Sbjct: 520 ARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNT 579
Query: 998 ALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDA 1057
LH+A +G +V L + N +D+ +TPLHLAA +G ++V + L +GA+++A
Sbjct: 580 PLHVACKDGNMPIVVALC-EANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEA 638
Query: 1058 TDELGQKPIHAAAQNNYSEVVQL 1080
G+ A + V L
Sbjct: 639 LTTDGKTAEDLARSEQHEHVAGL 661
Score = 89.8 bits (213), Expect = 9e-17
Identities = 70/264 (26%), Positives = 120/264 (45%), Gaps = 18/264 (6%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
ID D+ G++A+++A + + +K L EN + ++ + E A H A
Sbjct: 405 IDVQDKGGSNAVYWAARHGHVDT---------LKFLSENKCPLDVKDKSG-EMALHVAAR 454
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
G+ DV + + S ++ Q+ TPL A G+ + L V++ +
Sbjct: 455 YGHADVAQLLCSFGSNPNI------QDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKN 508
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
EG + L A+ GY + + L + A +N+ ++G ALHLA ++K L+
Sbjct: 509 REGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLL-SQG 567
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
+D TPLH+A G + + L E N+D +++ G+ P+H AA N +VV+
Sbjct: 568 CFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVR 627
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIA 1103
+L V A T DG T +A
Sbjct: 628 -YLCLMGASVEALTTDGKTAEDLA 650
Score = 86.2 bits (204), Expect = 1e-15
Identities = 54/157 (34%), Positives = 76/157 (48%), Gaps = 3/157 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G+ PLL A G +V L A+ L A G ALHLA RR +++ + L+
Sbjct: 509 REGETPLLTASARGYHDIVECL--AEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ 566
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G VD + G TPLH+A +G+ P+V N I++ RTP+HLAA NG ++
Sbjct: 567 GCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVV 626
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
L AS+ T DG T +A H A +L
Sbjct: 627 RYLC-LMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662
Score = 72.1 bits (169), Expect = 2e-11
Identities = 44/169 (26%), Positives = 83/169 (49%), Gaps = 3/169 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PLL+A GN +++ L+ + ++ G A++ AAR VD + L +
Sbjct: 377 KHGTPPLLIAAGCGNIQILQLLI--KRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSEN 434
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
+D + +G+ LH+AA G + + +N I D E+ TP+H AA +G+ ++
Sbjct: 435 KCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVA 494
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+ L + ++ + ++G T + AS G+ D L + G L+ +K
Sbjct: 495 KALCEA-GCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDK 542
Score = 70.9 bits (166), Expect = 4e-11
Identities = 56/194 (28%), Positives = 86/194 (44%), Gaps = 19/194 (9%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G+ +++ AAR+GHV + L + +DV ALH+A V + L +G++
Sbjct: 412 GSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNP 471
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+I+ K+ ETPLH AA A L ++G N +G TP+ A+ G +
Sbjct: 472 NIQ-DKEEETPLHCAA-WHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVEC 529
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
L E G D C D G L +A R C ++++ L+ F+D
Sbjct: 530 LAEHGAD----LNACDKD---GHIALHLAVRRCQMEVIKTLLS----------QGCFVDY 572
Query: 843 VDEDGASALHYACK 856
D G + LH ACK
Sbjct: 573 QDRHGNTPLHVACK 586
Score = 64.1 bits (149), Expect = 5e-09
Identities = 38/134 (28%), Positives = 66/134 (49%), Gaps = 1/134 (0%)
Query: 97 AGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRAN 156
+G+ ALH+AAR D+A++L +G+ + + +TPLH AA G + K N
Sbjct: 444 SGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCN 503
Query: 157 AAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMM 216
I + E TP+ A+ G+ I+E LA+ A + KDG +H+A +
Sbjct: 504 VNIKNREGETPLLTASARGYHDIVECLAE-HGADLNACDKDGHIALHLAVRRCQMEVIKT 562
Query: 217 LFKKGVYLHMPNKY 230
L +G ++ +++
Sbjct: 563 LLSQGCFVDYQDRH 576
Score = 62.1 bits (144), Expect = 2e-08
Identities = 37/120 (30%), Positives = 64/120 (53%), Gaps = 4/120 (3%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ +G + TA+ G+ I+ L + G ++ D + ALH+AV C+ V++TLL
Sbjct: 507 KNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ 566
Query: 719 GADVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
G V + + TPLH+A + DG+ + L ++ + + + G TP+H+AA G L
Sbjct: 567 GCFVDYQ-DRHGNTPLHVACK--DGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGIL 623
Score = 58.8 bits (136), Expect = 2e-07
Identities = 48/169 (28%), Positives = 72/169 (42%), Gaps = 13/169 (7%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K G ++H AARYGH + L G + ++ + T LH A +V + L
Sbjct: 441 KDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEA 500
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
G +V+I+ ++ ETPL + A L + GA N +DG +H+A + +
Sbjct: 501 GCNVNIK-NREGETPL-LTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQME 558
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVT--GETPLQMACRSCMPDIVRHLIE 825
+ LL G C D G TPL +AC+ IV L E
Sbjct: 559 VIKTLLSQG---------CFVDYQDRHGNTPLHVACKDGNMPIVVALCE 598
Score = 55.2 bits (127), Expect = 2e-06
Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 3/174 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D+ + G++ L +A G+ + + L S + ++ +T LH AA +A+
Sbjct: 439 DVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEE--ETPLHCAAWHGYYSVAKA 496
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L + G V+ N G+TPL A+A G +V+ A+ D + +HLA
Sbjct: 497 LCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQ 556
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
+I+ L + + + + G+T +H+A +G+ + L + L + NKY
Sbjct: 557 MEVIKTLLSQ-GCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKY 609
Score = 54.8 bits (126), Expect = 3e-06
Identities = 35/163 (21%), Positives = 76/163 (46%), Gaps = 1/163 (0%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
++ A+ N ++ LL + + + G L +AA ++ + ++L+ G+ +D
Sbjct: 348 IIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDV 407
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G ++ AA G +K+ + + D +H+AA GHA + +LL
Sbjct: 408 QDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLC-S 466
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
F ++ + K+ T +H A+ +G+ A L + G +++ N+
Sbjct: 467 FGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNR 509
Score = 49.2 bits (112), Expect = 2e-04
Identities = 34/122 (27%), Positives = 57/122 (46%), Gaps = 2/122 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G + L LAV +++ LLS + G+T LH+A + ++ + L +
Sbjct: 544 GHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRH--GNTPLHVACKDGNMPIVVALCEANC 601
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+D +N G+TPLH+AA G +V+Y + A+ + +T LA H + L
Sbjct: 602 NLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGL 661
Query: 183 LA 184
LA
Sbjct: 662 LA 663
>BC113660-1|AAI13661.1| 1430|Homo sapiens death-associated protein
kinase 1 protein.
Length = 1430
Score = 139 bits (337), Expect = 9e-32
Identities = 87/283 (30%), Positives = 150/283 (53%), Gaps = 8/283 (2%)
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
ND + H+ + + +N+ N G PLLIA G++Q++ L+ +R+DV D G
Sbjct: 353 NDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGG 412
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+A++ AA HG++ L NK ++ K ++G ALH+AA G+A + + L+ +
Sbjct: 413 SNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQ-LLCSFGSNP 471
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
++ +++TPLH AA G V K L E G N++ + G+ P+ A+ Y ++V+ L
Sbjct: 472 NIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVEC-L 530
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
+H + A KDG+ H+A + ++VI+ L+ G + +TPL +A +
Sbjct: 531 AEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLS---QGCFVDYQDRHGNTPLHVACKD 587
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMR 1185
G+ +V L A + N+ G T +HLAA +G +LDV+R
Sbjct: 588 GNMPIVVALCEANCNLDISNKYGRTPLHLAANNG---ILDVVR 627
Score = 121 bits (291), Expect = 3e-26
Identities = 89/306 (29%), Positives = 148/306 (48%), Gaps = 20/306 (6%)
Query: 1124 ISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDV 1183
++ NK + + PL +AA G+ ++++L++ G+ +++ G AV+ AA HGH + L
Sbjct: 372 VNQPNK-HGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKF 430
Query: 1184 MRSTNTLRISSK-KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAE 1242
+ S N + K K G LH+AA YG A+ + L S P + +
Sbjct: 431 L-SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSN-------------PNIQDK 476
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRS 1302
TPLH AA++G +V + L AG + N G PL A G+ IV L
Sbjct: 477 EEETPLHCAAWHGYYSVAKALCE-AGCNVNI-KNREGETPLLTASARGYHDIVECLAEHG 534
Query: 1303 AELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVV 1362
A+L ++ D+ G LH+A ++++ LL QG ++ D++G TPLH A K G++ +V
Sbjct: 535 ADL-NACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIV 593
Query: 1363 KLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCS 1422
LCE+ + P+ AA+ DV+ YL ++L D + +L S
Sbjct: 594 VALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDL-ARS 652
Query: 1423 KNHNNI 1428
+ H ++
Sbjct: 653 EQHEHV 658
Score = 117 bits (282), Expect = 4e-25
Identities = 104/352 (29%), Positives = 158/352 (44%), Gaps = 20/352 (5%)
Query: 1055 IDATDELGQKPI-HAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIE 1113
+D D K I HA +N + L V K G IAA G++++++
Sbjct: 337 LDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQ 396
Query: 1114 ELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAA 1173
L+K R I ++K S + AA GH D ++ L ++++G A+H+AA
Sbjct: 397 LLIK--RGSRIDVQDK-GGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAA 453
Query: 1174 EHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGV 1233
+GH +V ++ S + K TPLH AA++G + L EA V
Sbjct: 454 RYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALC---------EAGCNV 504
Query: 1234 SLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMS 1293
++ G TPL A+ G ++V L G +A +++G+ LHLA M
Sbjct: 505 NIKN----REGETPLLTASARGYHDIVECLAEH-GADLNAC-DKDGHIALHLAVRRCQME 558
Query: 1294 IVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCA 1353
++ LLS+ + DRHG T LH+A G+ +V L ++ ++K G TPLH A
Sbjct: 559 VIKTLLSQGC-FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLA 617
Query: 1354 AKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
A G L+VV+ LC GAS ++ T A SE H V L DT
Sbjct: 618 ANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDT 669
Score = 96.7 bits (230), Expect = 8e-19
Identities = 87/323 (26%), Positives = 146/323 (45%), Gaps = 34/323 (10%)
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMP 817
N+ + G P+ +AA GN+ L LL++ G +++ + D G + A R
Sbjct: 373 NQPNKHGTPPLLIAAGCGNIQILQLLIKRG------SRIDVQDK-GGSNAVYWAARHGHV 425
Query: 818 DIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIE 877
D ++ L E + +D D+ G ALH A + +V + L
Sbjct: 426 DTLKFLSE----------NKCPLDVKDKSGEMALHVAARYGHADV---------AQLLCS 466
Query: 878 NGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIAC 937
G++ ++Q + ET H A G V + + +N +N G TPLL A
Sbjct: 467 FGSNPNIQDKEE-ETPLHCAAWHGYYSVAKAL------CEAGCNVNIKNREGETPLLTAS 519
Query: 938 HRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRT 997
RG+ +V L + A ++ D +G ALHLA ++V LL+ F++ + R+G T
Sbjct: 520 ARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNT 579
Query: 998 ALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDA 1057
LH+A +G +V L + N +D+ +TPLHLAA +G ++V + L +GA+++A
Sbjct: 580 PLHVACKDGNMPIVVALC-EANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEA 638
Query: 1058 TDELGQKPIHAAAQNNYSEVVQL 1080
G+ A + V L
Sbjct: 639 LTTDGKTAEDLARSEQHEHVAGL 661
Score = 89.8 bits (213), Expect = 9e-17
Identities = 70/264 (26%), Positives = 120/264 (45%), Gaps = 18/264 (6%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
ID D+ G++A+++A + + +K L EN + ++ + E A H A
Sbjct: 405 IDVQDKGGSNAVYWAARHGHVDT---------LKFLSENKCPLDVKDKSG-EMALHVAAR 454
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
G+ DV + + S ++ Q+ TPL A G+ + L V++ +
Sbjct: 455 YGHADVAQLLCSFGSNPNI------QDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKN 508
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
EG + L A+ GY + + L + A +N+ ++G ALHLA ++K L+
Sbjct: 509 REGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLL-SQG 567
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
+D TPLH+A G + + L E N+D +++ G+ P+H AA N +VV+
Sbjct: 568 CFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVR 627
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIA 1103
+L V A T DG T +A
Sbjct: 628 -YLCLMGASVEALTTDGKTAEDLA 650
Score = 86.2 bits (204), Expect = 1e-15
Identities = 54/157 (34%), Positives = 76/157 (48%), Gaps = 3/157 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G+ PLL A G +V L A+ L A G ALHLA RR +++ + L+
Sbjct: 509 REGETPLLTASARGYHDIVECL--AEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ 566
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G VD + G TPLH+A +G+ P+V N I++ RTP+HLAA NG ++
Sbjct: 567 GCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVV 626
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
L AS+ T DG T +A H A +L
Sbjct: 627 RYLC-LMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662
Score = 72.1 bits (169), Expect = 2e-11
Identities = 44/169 (26%), Positives = 83/169 (49%), Gaps = 3/169 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PLL+A GN +++ L+ + ++ G A++ AAR VD + L +
Sbjct: 377 KHGTPPLLIAAGCGNIQILQLLI--KRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSEN 434
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
+D + +G+ LH+AA G + + +N I D E+ TP+H AA +G+ ++
Sbjct: 435 KCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVA 494
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+ L + ++ + ++G T + AS G+ D L + G L+ +K
Sbjct: 495 KALCEA-GCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDK 542
Score = 70.9 bits (166), Expect = 4e-11
Identities = 56/194 (28%), Positives = 86/194 (44%), Gaps = 19/194 (9%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G+ +++ AAR+GHV + L + +DV ALH+A V + L +G++
Sbjct: 412 GSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNP 471
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+I+ K+ ETPLH AA A L ++G N +G TP+ A+ G +
Sbjct: 472 NIQ-DKEEETPLHCAA-WHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVEC 529
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
L E G D C D G L +A R C ++++ L+ F+D
Sbjct: 530 LAEHGAD----LNACDKD---GHIALHLAVRRCQMEVIKTLLS----------QGCFVDY 572
Query: 843 VDEDGASALHYACK 856
D G + LH ACK
Sbjct: 573 QDRHGNTPLHVACK 586
Score = 64.1 bits (149), Expect = 5e-09
Identities = 38/134 (28%), Positives = 66/134 (49%), Gaps = 1/134 (0%)
Query: 97 AGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRAN 156
+G+ ALH+AAR D+A++L +G+ + + +TPLH AA G + K N
Sbjct: 444 SGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCN 503
Query: 157 AAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMM 216
I + E TP+ A+ G+ I+E LA+ A + KDG +H+A +
Sbjct: 504 VNIKNREGETPLLTASARGYHDIVECLAE-HGADLNACDKDGHIALHLAVRRCQMEVIKT 562
Query: 217 LFKKGVYLHMPNKY 230
L +G ++ +++
Sbjct: 563 LLSQGCFVDYQDRH 576
Score = 62.1 bits (144), Expect = 2e-08
Identities = 37/120 (30%), Positives = 64/120 (53%), Gaps = 4/120 (3%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ +G + TA+ G+ I+ L + G ++ D + ALH+AV C+ V++TLL
Sbjct: 507 KNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ 566
Query: 719 GADVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
G V + + TPLH+A + DG+ + L ++ + + + G TP+H+AA G L
Sbjct: 567 GCFVDYQ-DRHGNTPLHVACK--DGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGIL 623
Score = 58.8 bits (136), Expect = 2e-07
Identities = 48/169 (28%), Positives = 72/169 (42%), Gaps = 13/169 (7%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K G ++H AARYGH + L G + ++ + T LH A +V + L
Sbjct: 441 KDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEA 500
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
G +V+I+ ++ ETPL + A L + GA N +DG +H+A + +
Sbjct: 501 GCNVNIK-NREGETPL-LTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQME 558
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVT--GETPLQMACRSCMPDIVRHLIE 825
+ LL G C D G TPL +AC+ IV L E
Sbjct: 559 VIKTLLSQG---------CFVDYQDRHGNTPLHVACKDGNMPIVVALCE 598
Score = 55.2 bits (127), Expect = 2e-06
Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 3/174 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D+ + G++ L +A G+ + + L S + ++ +T LH AA +A+
Sbjct: 439 DVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEE--ETPLHCAAWHGYYSVAKA 496
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L + G V+ N G+TPL A+A G +V+ A+ D + +HLA
Sbjct: 497 LCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQ 556
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
+I+ L + + + + G+T +H+A +G+ + L + L + NKY
Sbjct: 557 MEVIKTLLSQ-GCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKY 609
Score = 54.8 bits (126), Expect = 3e-06
Identities = 35/163 (21%), Positives = 76/163 (46%), Gaps = 1/163 (0%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
++ A+ N ++ LL + + + G L +AA ++ + ++L+ G+ +D
Sbjct: 348 IIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDV 407
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G ++ AA G +K+ + + D +H+AA GHA + +LL
Sbjct: 408 QDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLC-S 466
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
F ++ + K+ T +H A+ +G+ A L + G +++ N+
Sbjct: 467 FGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNR 509
Score = 49.2 bits (112), Expect = 2e-04
Identities = 34/122 (27%), Positives = 57/122 (46%), Gaps = 2/122 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G + L LAV +++ LLS + G+T LH+A + ++ + L +
Sbjct: 544 GHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRH--GNTPLHVACKDGNMPIVVALCEANC 601
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+D +N G+TPLH+AA G +V+Y + A+ + +T LA H + L
Sbjct: 602 NLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGL 661
Query: 183 LA 184
LA
Sbjct: 662 LA 663
>AL591852-1|CAH71696.1| 1455|Homo sapiens death-associated protein
kinase 1 protein.
Length = 1455
Score = 139 bits (337), Expect = 9e-32
Identities = 87/283 (30%), Positives = 150/283 (53%), Gaps = 8/283 (2%)
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
ND + H+ + + +N+ N G PLLIA G++Q++ L+ +R+DV D G
Sbjct: 353 NDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGG 412
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+A++ AA HG++ L NK ++ K ++G ALH+AA G+A + + L+ +
Sbjct: 413 SNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQ-LLCSFGSNP 471
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
++ +++TPLH AA G V K L E G N++ + G+ P+ A+ Y ++V+ L
Sbjct: 472 NIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVEC-L 530
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
+H + A KDG+ H+A + ++VI+ L+ G + +TPL +A +
Sbjct: 531 AEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLS---QGCFVDYQDRHGNTPLHVACKD 587
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMR 1185
G+ +V L A + N+ G T +HLAA +G +LDV+R
Sbjct: 588 GNMPIVVALCEANCNLDISNKYGRTPLHLAANNG---ILDVVR 627
Score = 121 bits (291), Expect = 3e-26
Identities = 89/306 (29%), Positives = 148/306 (48%), Gaps = 20/306 (6%)
Query: 1124 ISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDV 1183
++ NK + + PL +AA G+ ++++L++ G+ +++ G AV+ AA HGH + L
Sbjct: 372 VNQPNK-HGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKF 430
Query: 1184 MRSTNTLRISSK-KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAE 1242
+ S N + K K G LH+AA YG A+ + L S P + +
Sbjct: 431 L-SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSN-------------PNIQDK 476
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRS 1302
TPLH AA++G +V + L AG + N G PL A G+ IV L
Sbjct: 477 EEETPLHCAAWHGYYSVAKALCE-AGCNVNI-KNREGETPLLTASARGYHDIVECLAEHG 534
Query: 1303 AELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVV 1362
A+L ++ D+ G LH+A ++++ LL QG ++ D++G TPLH A K G++ +V
Sbjct: 535 ADL-NACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIV 593
Query: 1363 KLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCS 1422
LCE+ + P+ AA+ DV+ YL ++L D + +L S
Sbjct: 594 VALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDL-ARS 652
Query: 1423 KNHNNI 1428
+ H ++
Sbjct: 653 EQHEHV 658
Score = 117 bits (282), Expect = 4e-25
Identities = 104/352 (29%), Positives = 158/352 (44%), Gaps = 20/352 (5%)
Query: 1055 IDATDELGQKPI-HAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIE 1113
+D D K I HA +N + L V K G IAA G++++++
Sbjct: 337 LDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQ 396
Query: 1114 ELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAA 1173
L+K R I ++K S + AA GH D ++ L ++++G A+H+AA
Sbjct: 397 LLIK--RGSRIDVQDK-GGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAA 453
Query: 1174 EHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGV 1233
+GH +V ++ S + K TPLH AA++G + L EA V
Sbjct: 454 RYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALC---------EAGCNV 504
Query: 1234 SLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMS 1293
++ G TPL A+ G ++V L G +A +++G+ LHLA M
Sbjct: 505 NIKN----REGETPLLTASARGYHDIVECLAEH-GADLNAC-DKDGHIALHLAVRRCQME 558
Query: 1294 IVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCA 1353
++ LLS+ + DRHG T LH+A G+ +V L ++ ++K G TPLH A
Sbjct: 559 VIKTLLSQGC-FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLA 617
Query: 1354 AKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
A G L+VV+ LC GAS ++ T A SE H V L DT
Sbjct: 618 ANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDT 669
Score = 96.7 bits (230), Expect = 8e-19
Identities = 87/323 (26%), Positives = 146/323 (45%), Gaps = 34/323 (10%)
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMP 817
N+ + G P+ +AA GN+ L LL++ G +++ + D G + A R
Sbjct: 373 NQPNKHGTPPLLIAAGCGNIQILQLLIKRG------SRIDVQDK-GGSNAVYWAARHGHV 425
Query: 818 DIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIE 877
D ++ L E + +D D+ G ALH A + +V + L
Sbjct: 426 DTLKFLSE----------NKCPLDVKDKSGEMALHVAARYGHADV---------AQLLCS 466
Query: 878 NGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIAC 937
G++ ++Q + ET H A G V + + +N +N G TPLL A
Sbjct: 467 FGSNPNIQDKEE-ETPLHCAAWHGYYSVAKAL------CEAGCNVNIKNREGETPLLTAS 519
Query: 938 HRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRT 997
RG+ +V L + A ++ D +G ALHLA ++V LL+ F++ + R+G T
Sbjct: 520 ARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNT 579
Query: 998 ALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDA 1057
LH+A +G +V L + N +D+ +TPLHLAA +G ++V + L +GA+++A
Sbjct: 580 PLHVACKDGNMPIVVALC-EANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEA 638
Query: 1058 TDELGQKPIHAAAQNNYSEVVQL 1080
G+ A + V L
Sbjct: 639 LTTDGKTAEDLARSEQHEHVAGL 661
Score = 89.8 bits (213), Expect = 9e-17
Identities = 70/264 (26%), Positives = 120/264 (45%), Gaps = 18/264 (6%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
ID D+ G++A+++A + + +K L EN + ++ + E A H A
Sbjct: 405 IDVQDKGGSNAVYWAARHGHVDT---------LKFLSENKCPLDVKDKSG-EMALHVAAR 454
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
G+ DV + + S ++ Q+ TPL A G+ + L V++ +
Sbjct: 455 YGHADVAQLLCSFGSNPNI------QDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKN 508
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
EG + L A+ GY + + L + A +N+ ++G ALHLA ++K L+
Sbjct: 509 REGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLL-SQG 567
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
+D TPLH+A G + + L E N+D +++ G+ P+H AA N +VV+
Sbjct: 568 CFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVR 627
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIA 1103
+L V A T DG T +A
Sbjct: 628 -YLCLMGASVEALTTDGKTAEDLA 650
Score = 86.2 bits (204), Expect = 1e-15
Identities = 54/157 (34%), Positives = 76/157 (48%), Gaps = 3/157 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G+ PLL A G +V L A+ L A G ALHLA RR +++ + L+
Sbjct: 509 REGETPLLTASARGYHDIVECL--AEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ 566
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G VD + G TPLH+A +G+ P+V N I++ RTP+HLAA NG ++
Sbjct: 567 GCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVV 626
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
L AS+ T DG T +A H A +L
Sbjct: 627 RYLC-LMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662
Score = 72.1 bits (169), Expect = 2e-11
Identities = 44/169 (26%), Positives = 83/169 (49%), Gaps = 3/169 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PLL+A GN +++ L+ + ++ G A++ AAR VD + L +
Sbjct: 377 KHGTPPLLIAAGCGNIQILQLLI--KRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSEN 434
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
+D + +G+ LH+AA G + + +N I D E+ TP+H AA +G+ ++
Sbjct: 435 KCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVA 494
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+ L + ++ + ++G T + AS G+ D L + G L+ +K
Sbjct: 495 KALCEA-GCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDK 542
Score = 70.9 bits (166), Expect = 4e-11
Identities = 56/194 (28%), Positives = 86/194 (44%), Gaps = 19/194 (9%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G+ +++ AAR+GHV + L + +DV ALH+A V + L +G++
Sbjct: 412 GSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNP 471
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+I+ K+ ETPLH AA A L ++G N +G TP+ A+ G +
Sbjct: 472 NIQ-DKEEETPLHCAA-WHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVEC 529
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
L E G D C D G L +A R C ++++ L+ F+D
Sbjct: 530 LAEHGAD----LNACDKD---GHIALHLAVRRCQMEVIKTLLS----------QGCFVDY 572
Query: 843 VDEDGASALHYACK 856
D G + LH ACK
Sbjct: 573 QDRHGNTPLHVACK 586
Score = 64.1 bits (149), Expect = 5e-09
Identities = 38/134 (28%), Positives = 66/134 (49%), Gaps = 1/134 (0%)
Query: 97 AGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRAN 156
+G+ ALH+AAR D+A++L +G+ + + +TPLH AA G + K N
Sbjct: 444 SGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCN 503
Query: 157 AAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMM 216
I + E TP+ A+ G+ I+E LA+ A + KDG +H+A +
Sbjct: 504 VNIKNREGETPLLTASARGYHDIVECLAE-HGADLNACDKDGHIALHLAVRRCQMEVIKT 562
Query: 217 LFKKGVYLHMPNKY 230
L +G ++ +++
Sbjct: 563 LLSQGCFVDYQDRH 576
Score = 62.1 bits (144), Expect = 2e-08
Identities = 37/120 (30%), Positives = 64/120 (53%), Gaps = 4/120 (3%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ +G + TA+ G+ I+ L + G ++ D + ALH+AV C+ V++TLL
Sbjct: 507 KNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ 566
Query: 719 GADVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
G V + + TPLH+A + DG+ + L ++ + + + G TP+H+AA G L
Sbjct: 567 GCFVDYQ-DRHGNTPLHVACK--DGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGIL 623
Score = 58.8 bits (136), Expect = 2e-07
Identities = 48/169 (28%), Positives = 72/169 (42%), Gaps = 13/169 (7%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K G ++H AARYGH + L G + ++ + T LH A +V + L
Sbjct: 441 KDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEA 500
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
G +V+I+ ++ ETPL + A L + GA N +DG +H+A + +
Sbjct: 501 GCNVNIK-NREGETPL-LTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQME 558
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVT--GETPLQMACRSCMPDIVRHLIE 825
+ LL G C D G TPL +AC+ IV L E
Sbjct: 559 VIKTLLSQG---------CFVDYQDRHGNTPLHVACKDGNMPIVVALCE 598
Score = 55.2 bits (127), Expect = 2e-06
Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 3/174 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D+ + G++ L +A G+ + + L S + ++ +T LH AA +A+
Sbjct: 439 DVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEE--ETPLHCAAWHGYYSVAKA 496
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L + G V+ N G+TPL A+A G +V+ A+ D + +HLA
Sbjct: 497 LCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQ 556
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
+I+ L + + + + G+T +H+A +G+ + L + L + NKY
Sbjct: 557 MEVIKTLLSQ-GCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKY 609
Score = 54.8 bits (126), Expect = 3e-06
Identities = 35/163 (21%), Positives = 76/163 (46%), Gaps = 1/163 (0%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
++ A+ N ++ LL + + + G L +AA ++ + ++L+ G+ +D
Sbjct: 348 IIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDV 407
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G ++ AA G +K+ + + D +H+AA GHA + +LL
Sbjct: 408 QDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLC-S 466
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
F ++ + K+ T +H A+ +G+ A L + G +++ N+
Sbjct: 467 FGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNR 509
Score = 49.2 bits (112), Expect = 2e-04
Identities = 34/122 (27%), Positives = 57/122 (46%), Gaps = 2/122 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G + L LAV +++ LLS + G+T LH+A + ++ + L +
Sbjct: 544 GHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRH--GNTPLHVACKDGNMPIVVALCEANC 601
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+D +N G+TPLH+AA G +V+Y + A+ + +T LA H + L
Sbjct: 602 NLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGL 661
Query: 183 LA 184
LA
Sbjct: 662 LA 663
>AL161787-1|CAH73544.1| 1455|Homo sapiens death-associated protein
kinase 1 protein.
Length = 1455
Score = 139 bits (337), Expect = 9e-32
Identities = 87/283 (30%), Positives = 150/283 (53%), Gaps = 8/283 (2%)
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
ND + H+ + + +N+ N G PLLIA G++Q++ L+ +R+DV D G
Sbjct: 353 NDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGG 412
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+A++ AA HG++ L NK ++ K ++G ALH+AA G+A + + L+ +
Sbjct: 413 SNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQ-LLCSFGSNP 471
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
++ +++TPLH AA G V K L E G N++ + G+ P+ A+ Y ++V+ L
Sbjct: 472 NIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVEC-L 530
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
+H + A KDG+ H+A + ++VI+ L+ G + +TPL +A +
Sbjct: 531 AEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLS---QGCFVDYQDRHGNTPLHVACKD 587
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMR 1185
G+ +V L A + N+ G T +HLAA +G +LDV+R
Sbjct: 588 GNMPIVVALCEANCNLDISNKYGRTPLHLAANNG---ILDVVR 627
Score = 121 bits (291), Expect = 3e-26
Identities = 89/306 (29%), Positives = 148/306 (48%), Gaps = 20/306 (6%)
Query: 1124 ISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDV 1183
++ NK + + PL +AA G+ ++++L++ G+ +++ G AV+ AA HGH + L
Sbjct: 372 VNQPNK-HGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKF 430
Query: 1184 MRSTNTLRISSK-KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAE 1242
+ S N + K K G LH+AA YG A+ + L S P + +
Sbjct: 431 L-SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSN-------------PNIQDK 476
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRS 1302
TPLH AA++G +V + L AG + N G PL A G+ IV L
Sbjct: 477 EEETPLHCAAWHGYYSVAKALCE-AGCNVNI-KNREGETPLLTASARGYHDIVECLAEHG 534
Query: 1303 AELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVV 1362
A+L ++ D+ G LH+A ++++ LL QG ++ D++G TPLH A K G++ +V
Sbjct: 535 ADL-NACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIV 593
Query: 1363 KLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCS 1422
LCE+ + P+ AA+ DV+ YL ++L D + +L S
Sbjct: 594 VALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDL-ARS 652
Query: 1423 KNHNNI 1428
+ H ++
Sbjct: 653 EQHEHV 658
Score = 117 bits (282), Expect = 4e-25
Identities = 104/352 (29%), Positives = 158/352 (44%), Gaps = 20/352 (5%)
Query: 1055 IDATDELGQKPI-HAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIE 1113
+D D K I HA +N + L V K G IAA G++++++
Sbjct: 337 LDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQ 396
Query: 1114 ELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAA 1173
L+K R I ++K S + AA GH D ++ L ++++G A+H+AA
Sbjct: 397 LLIK--RGSRIDVQDK-GGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAA 453
Query: 1174 EHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGV 1233
+GH +V ++ S + K TPLH AA++G + L EA V
Sbjct: 454 RYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALC---------EAGCNV 504
Query: 1234 SLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMS 1293
++ G TPL A+ G ++V L G +A +++G+ LHLA M
Sbjct: 505 NIKN----REGETPLLTASARGYHDIVECLAEH-GADLNAC-DKDGHIALHLAVRRCQME 558
Query: 1294 IVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCA 1353
++ LLS+ + DRHG T LH+A G+ +V L ++ ++K G TPLH A
Sbjct: 559 VIKTLLSQGC-FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLA 617
Query: 1354 AKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
A G L+VV+ LC GAS ++ T A SE H V L DT
Sbjct: 618 ANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDT 669
Score = 96.7 bits (230), Expect = 8e-19
Identities = 87/323 (26%), Positives = 146/323 (45%), Gaps = 34/323 (10%)
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMP 817
N+ + G P+ +AA GN+ L LL++ G +++ + D G + A R
Sbjct: 373 NQPNKHGTPPLLIAAGCGNIQILQLLIKRG------SRIDVQDK-GGSNAVYWAARHGHV 425
Query: 818 DIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIE 877
D ++ L E + +D D+ G ALH A + +V + L
Sbjct: 426 DTLKFLSE----------NKCPLDVKDKSGEMALHVAARYGHADV---------AQLLCS 466
Query: 878 NGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIAC 937
G++ ++Q + ET H A G V + + +N +N G TPLL A
Sbjct: 467 FGSNPNIQDKEE-ETPLHCAAWHGYYSVAKAL------CEAGCNVNIKNREGETPLLTAS 519
Query: 938 HRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRT 997
RG+ +V L + A ++ D +G ALHLA ++V LL+ F++ + R+G T
Sbjct: 520 ARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNT 579
Query: 998 ALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDA 1057
LH+A +G +V L + N +D+ +TPLHLAA +G ++V + L +GA+++A
Sbjct: 580 PLHVACKDGNMPIVVALC-EANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEA 638
Query: 1058 TDELGQKPIHAAAQNNYSEVVQL 1080
G+ A + V L
Sbjct: 639 LTTDGKTAEDLARSEQHEHVAGL 661
Score = 89.8 bits (213), Expect = 9e-17
Identities = 70/264 (26%), Positives = 120/264 (45%), Gaps = 18/264 (6%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
ID D+ G++A+++A + + +K L EN + ++ + E A H A
Sbjct: 405 IDVQDKGGSNAVYWAARHGHVDT---------LKFLSENKCPLDVKDKSG-EMALHVAAR 454
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
G+ DV + + S ++ Q+ TPL A G+ + L V++ +
Sbjct: 455 YGHADVAQLLCSFGSNPNI------QDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKN 508
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
EG + L A+ GY + + L + A +N+ ++G ALHLA ++K L+
Sbjct: 509 REGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLL-SQG 567
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
+D TPLH+A G + + L E N+D +++ G+ P+H AA N +VV+
Sbjct: 568 CFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVR 627
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIA 1103
+L V A T DG T +A
Sbjct: 628 -YLCLMGASVEALTTDGKTAEDLA 650
Score = 86.2 bits (204), Expect = 1e-15
Identities = 54/157 (34%), Positives = 76/157 (48%), Gaps = 3/157 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G+ PLL A G +V L A+ L A G ALHLA RR +++ + L+
Sbjct: 509 REGETPLLTASARGYHDIVECL--AEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ 566
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G VD + G TPLH+A +G+ P+V N I++ RTP+HLAA NG ++
Sbjct: 567 GCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVV 626
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
L AS+ T DG T +A H A +L
Sbjct: 627 RYLC-LMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662
Score = 72.1 bits (169), Expect = 2e-11
Identities = 44/169 (26%), Positives = 83/169 (49%), Gaps = 3/169 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PLL+A GN +++ L+ + ++ G A++ AAR VD + L +
Sbjct: 377 KHGTPPLLIAAGCGNIQILQLLI--KRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSEN 434
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
+D + +G+ LH+AA G + + +N I D E+ TP+H AA +G+ ++
Sbjct: 435 KCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVA 494
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+ L + ++ + ++G T + AS G+ D L + G L+ +K
Sbjct: 495 KALCEA-GCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDK 542
Score = 70.9 bits (166), Expect = 4e-11
Identities = 56/194 (28%), Positives = 86/194 (44%), Gaps = 19/194 (9%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G+ +++ AAR+GHV + L + +DV ALH+A V + L +G++
Sbjct: 412 GSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNP 471
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+I+ K+ ETPLH AA A L ++G N +G TP+ A+ G +
Sbjct: 472 NIQ-DKEEETPLHCAA-WHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVEC 529
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
L E G D C D G L +A R C ++++ L+ F+D
Sbjct: 530 LAEHGAD----LNACDKD---GHIALHLAVRRCQMEVIKTLLS----------QGCFVDY 572
Query: 843 VDEDGASALHYACK 856
D G + LH ACK
Sbjct: 573 QDRHGNTPLHVACK 586
Score = 64.1 bits (149), Expect = 5e-09
Identities = 38/134 (28%), Positives = 66/134 (49%), Gaps = 1/134 (0%)
Query: 97 AGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRAN 156
+G+ ALH+AAR D+A++L +G+ + + +TPLH AA G + K N
Sbjct: 444 SGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCN 503
Query: 157 AAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMM 216
I + E TP+ A+ G+ I+E LA+ A + KDG +H+A +
Sbjct: 504 VNIKNREGETPLLTASARGYHDIVECLAE-HGADLNACDKDGHIALHLAVRRCQMEVIKT 562
Query: 217 LFKKGVYLHMPNKY 230
L +G ++ +++
Sbjct: 563 LLSQGCFVDYQDRH 576
Score = 62.1 bits (144), Expect = 2e-08
Identities = 37/120 (30%), Positives = 64/120 (53%), Gaps = 4/120 (3%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ +G + TA+ G+ I+ L + G ++ D + ALH+AV C+ V++TLL
Sbjct: 507 KNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ 566
Query: 719 GADVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
G V + + TPLH+A + DG+ + L ++ + + + G TP+H+AA G L
Sbjct: 567 GCFVDYQ-DRHGNTPLHVACK--DGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGIL 623
Score = 58.8 bits (136), Expect = 2e-07
Identities = 48/169 (28%), Positives = 72/169 (42%), Gaps = 13/169 (7%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K G ++H AARYGH + L G + ++ + T LH A +V + L
Sbjct: 441 KDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEA 500
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
G +V+I+ ++ ETPL + A L + GA N +DG +H+A + +
Sbjct: 501 GCNVNIK-NREGETPL-LTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQME 558
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVT--GETPLQMACRSCMPDIVRHLIE 825
+ LL G C D G TPL +AC+ IV L E
Sbjct: 559 VIKTLLSQG---------CFVDYQDRHGNTPLHVACKDGNMPIVVALCE 598
Score = 55.2 bits (127), Expect = 2e-06
Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 3/174 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D+ + G++ L +A G+ + + L S + ++ +T LH AA +A+
Sbjct: 439 DVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEE--ETPLHCAAWHGYYSVAKA 496
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L + G V+ N G+TPL A+A G +V+ A+ D + +HLA
Sbjct: 497 LCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQ 556
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
+I+ L + + + + G+T +H+A +G+ + L + L + NKY
Sbjct: 557 MEVIKTLLSQ-GCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKY 609
Score = 54.8 bits (126), Expect = 3e-06
Identities = 35/163 (21%), Positives = 76/163 (46%), Gaps = 1/163 (0%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
++ A+ N ++ LL + + + G L +AA ++ + ++L+ G+ +D
Sbjct: 348 IIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDV 407
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G ++ AA G +K+ + + D +H+AA GHA + +LL
Sbjct: 408 QDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLC-S 466
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
F ++ + K+ T +H A+ +G+ A L + G +++ N+
Sbjct: 467 FGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNR 509
Score = 49.2 bits (112), Expect = 2e-04
Identities = 34/122 (27%), Positives = 57/122 (46%), Gaps = 2/122 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G + L LAV +++ LLS + G+T LH+A + ++ + L +
Sbjct: 544 GHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRH--GNTPLHVACKDGNMPIVVALCEANC 601
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+D +N G+TPLH+AA G +V+Y + A+ + +T LA H + L
Sbjct: 602 NLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGL 661
Query: 183 LA 184
LA
Sbjct: 662 LA 663
>AL160279-1|CAI16306.1| 1455|Homo sapiens death-associated protein
kinase 1 protein.
Length = 1455
Score = 139 bits (337), Expect = 9e-32
Identities = 87/283 (30%), Positives = 150/283 (53%), Gaps = 8/283 (2%)
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
ND + H+ + + +N+ N G PLLIA G++Q++ L+ +R+DV D G
Sbjct: 353 NDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGG 412
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+A++ AA HG++ L NK ++ K ++G ALH+AA G+A + + L+ +
Sbjct: 413 SNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQ-LLCSFGSNP 471
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
++ +++TPLH AA G V K L E G N++ + G+ P+ A+ Y ++V+ L
Sbjct: 472 NIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVEC-L 530
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
+H + A KDG+ H+A + ++VI+ L+ G + +TPL +A +
Sbjct: 531 AEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLS---QGCFVDYQDRHGNTPLHVACKD 587
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMR 1185
G+ +V L A + N+ G T +HLAA +G +LDV+R
Sbjct: 588 GNMPIVVALCEANCNLDISNKYGRTPLHLAANNG---ILDVVR 627
Score = 121 bits (291), Expect = 3e-26
Identities = 89/306 (29%), Positives = 148/306 (48%), Gaps = 20/306 (6%)
Query: 1124 ISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDV 1183
++ NK + + PL +AA G+ ++++L++ G+ +++ G AV+ AA HGH + L
Sbjct: 372 VNQPNK-HGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKF 430
Query: 1184 MRSTNTLRISSK-KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAE 1242
+ S N + K K G LH+AA YG A+ + L S P + +
Sbjct: 431 L-SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSN-------------PNIQDK 476
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRS 1302
TPLH AA++G +V + L AG + N G PL A G+ IV L
Sbjct: 477 EEETPLHCAAWHGYYSVAKALCE-AGCNVNI-KNREGETPLLTASARGYHDIVECLAEHG 534
Query: 1303 AELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVV 1362
A+L ++ D+ G LH+A ++++ LL QG ++ D++G TPLH A K G++ +V
Sbjct: 535 ADL-NACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIV 593
Query: 1363 KLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCS 1422
LCE+ + P+ AA+ DV+ YL ++L D + +L S
Sbjct: 594 VALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDL-ARS 652
Query: 1423 KNHNNI 1428
+ H ++
Sbjct: 653 EQHEHV 658
Score = 117 bits (282), Expect = 4e-25
Identities = 104/352 (29%), Positives = 158/352 (44%), Gaps = 20/352 (5%)
Query: 1055 IDATDELGQKPI-HAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIE 1113
+D D K I HA +N + L V K G IAA G++++++
Sbjct: 337 LDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQ 396
Query: 1114 ELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAA 1173
L+K R I ++K S + AA GH D ++ L ++++G A+H+AA
Sbjct: 397 LLIK--RGSRIDVQDK-GGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAA 453
Query: 1174 EHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGV 1233
+GH +V ++ S + K TPLH AA++G + L EA V
Sbjct: 454 RYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALC---------EAGCNV 504
Query: 1234 SLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMS 1293
++ G TPL A+ G ++V L G +A +++G+ LHLA M
Sbjct: 505 NIKN----REGETPLLTASARGYHDIVECLAEH-GADLNAC-DKDGHIALHLAVRRCQME 558
Query: 1294 IVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCA 1353
++ LLS+ + DRHG T LH+A G+ +V L ++ ++K G TPLH A
Sbjct: 559 VIKTLLSQGC-FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLA 617
Query: 1354 AKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
A G L+VV+ LC GAS ++ T A SE H V L DT
Sbjct: 618 ANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDT 669
Score = 96.7 bits (230), Expect = 8e-19
Identities = 87/323 (26%), Positives = 146/323 (45%), Gaps = 34/323 (10%)
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMP 817
N+ + G P+ +AA GN+ L LL++ G +++ + D G + A R
Sbjct: 373 NQPNKHGTPPLLIAAGCGNIQILQLLIKRG------SRIDVQDK-GGSNAVYWAARHGHV 425
Query: 818 DIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIE 877
D ++ L E + +D D+ G ALH A + +V + L
Sbjct: 426 DTLKFLSE----------NKCPLDVKDKSGEMALHVAARYGHADV---------AQLLCS 466
Query: 878 NGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIAC 937
G++ ++Q + ET H A G V + + +N +N G TPLL A
Sbjct: 467 FGSNPNIQDKEE-ETPLHCAAWHGYYSVAKAL------CEAGCNVNIKNREGETPLLTAS 519
Query: 938 HRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRT 997
RG+ +V L + A ++ D +G ALHLA ++V LL+ F++ + R+G T
Sbjct: 520 ARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNT 579
Query: 998 ALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDA 1057
LH+A +G +V L + N +D+ +TPLHLAA +G ++V + L +GA+++A
Sbjct: 580 PLHVACKDGNMPIVVALC-EANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEA 638
Query: 1058 TDELGQKPIHAAAQNNYSEVVQL 1080
G+ A + V L
Sbjct: 639 LTTDGKTAEDLARSEQHEHVAGL 661
Score = 89.8 bits (213), Expect = 9e-17
Identities = 70/264 (26%), Positives = 120/264 (45%), Gaps = 18/264 (6%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
ID D+ G++A+++A + + +K L EN + ++ + E A H A
Sbjct: 405 IDVQDKGGSNAVYWAARHGHVDT---------LKFLSENKCPLDVKDKSG-EMALHVAAR 454
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
G+ DV + + S ++ Q+ TPL A G+ + L V++ +
Sbjct: 455 YGHADVAQLLCSFGSNPNI------QDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKN 508
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
EG + L A+ GY + + L + A +N+ ++G ALHLA ++K L+
Sbjct: 509 REGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLL-SQG 567
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
+D TPLH+A G + + L E N+D +++ G+ P+H AA N +VV+
Sbjct: 568 CFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVR 627
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIA 1103
+L V A T DG T +A
Sbjct: 628 -YLCLMGASVEALTTDGKTAEDLA 650
Score = 86.2 bits (204), Expect = 1e-15
Identities = 54/157 (34%), Positives = 76/157 (48%), Gaps = 3/157 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G+ PLL A G +V L A+ L A G ALHLA RR +++ + L+
Sbjct: 509 REGETPLLTASARGYHDIVECL--AEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ 566
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G VD + G TPLH+A +G+ P+V N I++ RTP+HLAA NG ++
Sbjct: 567 GCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVV 626
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
L AS+ T DG T +A H A +L
Sbjct: 627 RYLC-LMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662
Score = 72.1 bits (169), Expect = 2e-11
Identities = 44/169 (26%), Positives = 83/169 (49%), Gaps = 3/169 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PLL+A GN +++ L+ + ++ G A++ AAR VD + L +
Sbjct: 377 KHGTPPLLIAAGCGNIQILQLLI--KRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSEN 434
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
+D + +G+ LH+AA G + + +N I D E+ TP+H AA +G+ ++
Sbjct: 435 KCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVA 494
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+ L + ++ + ++G T + AS G+ D L + G L+ +K
Sbjct: 495 KALCEA-GCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDK 542
Score = 70.9 bits (166), Expect = 4e-11
Identities = 56/194 (28%), Positives = 86/194 (44%), Gaps = 19/194 (9%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G+ +++ AAR+GHV + L + +DV ALH+A V + L +G++
Sbjct: 412 GSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNP 471
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+I+ K+ ETPLH AA A L ++G N +G TP+ A+ G +
Sbjct: 472 NIQ-DKEEETPLHCAA-WHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVEC 529
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
L E G D C D G L +A R C ++++ L+ F+D
Sbjct: 530 LAEHGAD----LNACDKD---GHIALHLAVRRCQMEVIKTLLS----------QGCFVDY 572
Query: 843 VDEDGASALHYACK 856
D G + LH ACK
Sbjct: 573 QDRHGNTPLHVACK 586
Score = 64.1 bits (149), Expect = 5e-09
Identities = 38/134 (28%), Positives = 66/134 (49%), Gaps = 1/134 (0%)
Query: 97 AGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRAN 156
+G+ ALH+AAR D+A++L +G+ + + +TPLH AA G + K N
Sbjct: 444 SGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCN 503
Query: 157 AAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMM 216
I + E TP+ A+ G+ I+E LA+ A + KDG +H+A +
Sbjct: 504 VNIKNREGETPLLTASARGYHDIVECLAE-HGADLNACDKDGHIALHLAVRRCQMEVIKT 562
Query: 217 LFKKGVYLHMPNKY 230
L +G ++ +++
Sbjct: 563 LLSQGCFVDYQDRH 576
Score = 62.1 bits (144), Expect = 2e-08
Identities = 37/120 (30%), Positives = 64/120 (53%), Gaps = 4/120 (3%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ +G + TA+ G+ I+ L + G ++ D + ALH+AV C+ V++TLL
Sbjct: 507 KNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ 566
Query: 719 GADVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
G V + + TPLH+A + DG+ + L ++ + + + G TP+H+AA G L
Sbjct: 567 GCFVDYQ-DRHGNTPLHVACK--DGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGIL 623
Score = 58.8 bits (136), Expect = 2e-07
Identities = 48/169 (28%), Positives = 72/169 (42%), Gaps = 13/169 (7%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K G ++H AARYGH + L G + ++ + T LH A +V + L
Sbjct: 441 KDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEA 500
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
G +V+I+ ++ ETPL + A L + GA N +DG +H+A + +
Sbjct: 501 GCNVNIK-NREGETPL-LTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQME 558
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVT--GETPLQMACRSCMPDIVRHLIE 825
+ LL G C D G TPL +AC+ IV L E
Sbjct: 559 VIKTLLSQG---------CFVDYQDRHGNTPLHVACKDGNMPIVVALCE 598
Score = 55.2 bits (127), Expect = 2e-06
Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 3/174 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D+ + G++ L +A G+ + + L S + ++ +T LH AA +A+
Sbjct: 439 DVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEE--ETPLHCAAWHGYYSVAKA 496
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L + G V+ N G+TPL A+A G +V+ A+ D + +HLA
Sbjct: 497 LCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQ 556
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
+I+ L + + + + G+T +H+A +G+ + L + L + NKY
Sbjct: 557 MEVIKTLLSQ-GCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKY 609
Score = 54.8 bits (126), Expect = 3e-06
Identities = 35/163 (21%), Positives = 76/163 (46%), Gaps = 1/163 (0%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
++ A+ N ++ LL + + + G L +AA ++ + ++L+ G+ +D
Sbjct: 348 IIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDV 407
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G ++ AA G +K+ + + D +H+AA GHA + +LL
Sbjct: 408 QDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLC-S 466
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
F ++ + K+ T +H A+ +G+ A L + G +++ N+
Sbjct: 467 FGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNR 509
Score = 49.2 bits (112), Expect = 2e-04
Identities = 34/122 (27%), Positives = 57/122 (46%), Gaps = 2/122 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G + L LAV +++ LLS + G+T LH+A + ++ + L +
Sbjct: 544 GHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRH--GNTPLHVACKDGNMPIVVALCEANC 601
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+D +N G+TPLH+AA G +V+Y + A+ + +T LA H + L
Sbjct: 602 NLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGL 661
Query: 183 LA 184
LA
Sbjct: 662 LA 663
>AB208871-1|BAD92108.1| 1433|Homo sapiens Hypothetical protein
DKFZp781I035 variant protein.
Length = 1433
Score = 139 bits (337), Expect = 9e-32
Identities = 87/283 (30%), Positives = 150/283 (53%), Gaps = 8/283 (2%)
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
ND + H+ + + +N+ N G PLLIA G++Q++ L+ +R+DV D G
Sbjct: 356 NDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGG 415
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+A++ AA HG++ L NK ++ K ++G ALH+AA G+A + + L+ +
Sbjct: 416 SNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQ-LLCSFGSNP 474
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
++ +++TPLH AA G V K L E G N++ + G+ P+ A+ Y ++V+ L
Sbjct: 475 NIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVEC-L 533
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
+H + A KDG+ H+A + ++VI+ L+ G + +TPL +A +
Sbjct: 534 AEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLS---QGCFVDYQDRHGNTPLHVACKD 590
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMR 1185
G+ +V L A + N+ G T +HLAA +G +LDV+R
Sbjct: 591 GNMPIVVALCEANCNLDISNKYGRTPLHLAANNG---ILDVVR 630
Score = 121 bits (291), Expect = 3e-26
Identities = 89/306 (29%), Positives = 148/306 (48%), Gaps = 20/306 (6%)
Query: 1124 ISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDV 1183
++ NK + + PL +AA G+ ++++L++ G+ +++ G AV+ AA HGH + L
Sbjct: 375 VNQPNK-HGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKF 433
Query: 1184 MRSTNTLRISSK-KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAE 1242
+ S N + K K G LH+AA YG A+ + L S P + +
Sbjct: 434 L-SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSN-------------PNIQDK 479
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRS 1302
TPLH AA++G +V + L AG + N G PL A G+ IV L
Sbjct: 480 EEETPLHCAAWHGYYSVAKALCE-AGCNVNI-KNREGETPLLTASARGYHDIVECLAEHG 537
Query: 1303 AELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVV 1362
A+L ++ D+ G LH+A ++++ LL QG ++ D++G TPLH A K G++ +V
Sbjct: 538 ADL-NACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIV 596
Query: 1363 KLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCS 1422
LCE+ + P+ AA+ DV+ YL ++L D + +L S
Sbjct: 597 VALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDL-ARS 655
Query: 1423 KNHNNI 1428
+ H ++
Sbjct: 656 EQHEHV 661
Score = 117 bits (282), Expect = 4e-25
Identities = 104/352 (29%), Positives = 158/352 (44%), Gaps = 20/352 (5%)
Query: 1055 IDATDELGQKPI-HAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIE 1113
+D D K I HA +N + L V K G IAA G++++++
Sbjct: 340 LDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQ 399
Query: 1114 ELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAA 1173
L+K R I ++K S + AA GH D ++ L ++++G A+H+AA
Sbjct: 400 LLIK--RGSRIDVQDK-GGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAA 456
Query: 1174 EHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGV 1233
+GH +V ++ S + K TPLH AA++G + L EA V
Sbjct: 457 RYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALC---------EAGCNV 507
Query: 1234 SLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMS 1293
++ G TPL A+ G ++V L G +A +++G+ LHLA M
Sbjct: 508 NIKN----REGETPLLTASARGYHDIVECLAEH-GADLNAC-DKDGHIALHLAVRRCQME 561
Query: 1294 IVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCA 1353
++ LLS+ + DRHG T LH+A G+ +V L ++ ++K G TPLH A
Sbjct: 562 VIKTLLSQGC-FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLA 620
Query: 1354 AKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
A G L+VV+ LC GAS ++ T A SE H V L DT
Sbjct: 621 ANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDT 672
Score = 96.7 bits (230), Expect = 8e-19
Identities = 87/323 (26%), Positives = 146/323 (45%), Gaps = 34/323 (10%)
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMP 817
N+ + G P+ +AA GN+ L LL++ G +++ + D G + A R
Sbjct: 376 NQPNKHGTPPLLIAAGCGNIQILQLLIKRG------SRIDVQDK-GGSNAVYWAARHGHV 428
Query: 818 DIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIE 877
D ++ L E + +D D+ G ALH A + +V + L
Sbjct: 429 DTLKFLSE----------NKCPLDVKDKSGEMALHVAARYGHADV---------AQLLCS 469
Query: 878 NGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIAC 937
G++ ++Q + ET H A G V + + +N +N G TPLL A
Sbjct: 470 FGSNPNIQDKEE-ETPLHCAAWHGYYSVAKAL------CEAGCNVNIKNREGETPLLTAS 522
Query: 938 HRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRT 997
RG+ +V L + A ++ D +G ALHLA ++V LL+ F++ + R+G T
Sbjct: 523 ARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNT 582
Query: 998 ALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDA 1057
LH+A +G +V L + N +D+ +TPLHLAA +G ++V + L +GA+++A
Sbjct: 583 PLHVACKDGNMPIVVALC-EANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEA 641
Query: 1058 TDELGQKPIHAAAQNNYSEVVQL 1080
G+ A + V L
Sbjct: 642 LTTDGKTAEDLARSEQHEHVAGL 664
Score = 89.8 bits (213), Expect = 9e-17
Identities = 70/264 (26%), Positives = 120/264 (45%), Gaps = 18/264 (6%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
ID D+ G++A+++A + + +K L EN + ++ + E A H A
Sbjct: 408 IDVQDKGGSNAVYWAARHGHVDT---------LKFLSENKCPLDVKDKSG-EMALHVAAR 457
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
G+ DV + + S ++ Q+ TPL A G+ + L V++ +
Sbjct: 458 YGHADVAQLLCSFGSNPNI------QDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKN 511
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
EG + L A+ GY + + L + A +N+ ++G ALHLA ++K L+
Sbjct: 512 REGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLL-SQG 570
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
+D TPLH+A G + + L E N+D +++ G+ P+H AA N +VV+
Sbjct: 571 CFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVR 630
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIA 1103
+L V A T DG T +A
Sbjct: 631 -YLCLMGASVEALTTDGKTAEDLA 653
Score = 86.2 bits (204), Expect = 1e-15
Identities = 54/157 (34%), Positives = 76/157 (48%), Gaps = 3/157 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G+ PLL A G +V L A+ L A G ALHLA RR +++ + L+
Sbjct: 512 REGETPLLTASARGYHDIVECL--AEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ 569
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G VD + G TPLH+A +G+ P+V N I++ RTP+HLAA NG ++
Sbjct: 570 GCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVV 629
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
L AS+ T DG T +A H A +L
Sbjct: 630 RYLC-LMGASVEALTTDGKTAEDLARSEQHEHVAGLL 665
Score = 72.1 bits (169), Expect = 2e-11
Identities = 44/169 (26%), Positives = 83/169 (49%), Gaps = 3/169 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PLL+A GN +++ L+ + ++ G A++ AAR VD + L +
Sbjct: 380 KHGTPPLLIAAGCGNIQILQLLI--KRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSEN 437
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
+D + +G+ LH+AA G + + +N I D E+ TP+H AA +G+ ++
Sbjct: 438 KCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVA 497
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+ L + ++ + ++G T + AS G+ D L + G L+ +K
Sbjct: 498 KALCEA-GCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDK 545
Score = 70.9 bits (166), Expect = 4e-11
Identities = 56/194 (28%), Positives = 86/194 (44%), Gaps = 19/194 (9%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G+ +++ AAR+GHV + L + +DV ALH+A V + L +G++
Sbjct: 415 GSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNP 474
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+I+ K+ ETPLH AA A L ++G N +G TP+ A+ G +
Sbjct: 475 NIQ-DKEEETPLHCAA-WHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVEC 532
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
L E G D C D G L +A R C ++++ L+ F+D
Sbjct: 533 LAEHGAD----LNACDKD---GHIALHLAVRRCQMEVIKTLLS----------QGCFVDY 575
Query: 843 VDEDGASALHYACK 856
D G + LH ACK
Sbjct: 576 QDRHGNTPLHVACK 589
Score = 64.1 bits (149), Expect = 5e-09
Identities = 38/134 (28%), Positives = 66/134 (49%), Gaps = 1/134 (0%)
Query: 97 AGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRAN 156
+G+ ALH+AAR D+A++L +G+ + + +TPLH AA G + K N
Sbjct: 447 SGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCN 506
Query: 157 AAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMM 216
I + E TP+ A+ G+ I+E LA+ A + KDG +H+A +
Sbjct: 507 VNIKNREGETPLLTASARGYHDIVECLAE-HGADLNACDKDGHIALHLAVRRCQMEVIKT 565
Query: 217 LFKKGVYLHMPNKY 230
L +G ++ +++
Sbjct: 566 LLSQGCFVDYQDRH 579
Score = 62.1 bits (144), Expect = 2e-08
Identities = 37/120 (30%), Positives = 64/120 (53%), Gaps = 4/120 (3%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ +G + TA+ G+ I+ L + G ++ D + ALH+AV C+ V++TLL
Sbjct: 510 KNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ 569
Query: 719 GADVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
G V + + TPLH+A + DG+ + L ++ + + + G TP+H+AA G L
Sbjct: 570 GCFVDYQ-DRHGNTPLHVACK--DGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGIL 626
Score = 58.8 bits (136), Expect = 2e-07
Identities = 48/169 (28%), Positives = 72/169 (42%), Gaps = 13/169 (7%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K G ++H AARYGH + L G + ++ + T LH A +V + L
Sbjct: 444 KDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEA 503
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
G +V+I+ ++ ETPL + A L + GA N +DG +H+A + +
Sbjct: 504 GCNVNIK-NREGETPL-LTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQME 561
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVT--GETPLQMACRSCMPDIVRHLIE 825
+ LL G C D G TPL +AC+ IV L E
Sbjct: 562 VIKTLLSQG---------CFVDYQDRHGNTPLHVACKDGNMPIVVALCE 601
Score = 55.2 bits (127), Expect = 2e-06
Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 3/174 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D+ + G++ L +A G+ + + L S + ++ +T LH AA +A+
Sbjct: 442 DVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEE--ETPLHCAAWHGYYSVAKA 499
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L + G V+ N G+TPL A+A G +V+ A+ D + +HLA
Sbjct: 500 LCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQ 559
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
+I+ L + + + + G+T +H+A +G+ + L + L + NKY
Sbjct: 560 MEVIKTLLSQ-GCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKY 612
Score = 54.8 bits (126), Expect = 3e-06
Identities = 35/163 (21%), Positives = 76/163 (46%), Gaps = 1/163 (0%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
++ A+ N ++ LL + + + G L +AA ++ + ++L+ G+ +D
Sbjct: 351 IIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDV 410
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G ++ AA G +K+ + + D +H+AA GHA + +LL
Sbjct: 411 QDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLC-S 469
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
F ++ + K+ T +H A+ +G+ A L + G +++ N+
Sbjct: 470 FGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNR 512
Score = 49.2 bits (112), Expect = 2e-04
Identities = 34/122 (27%), Positives = 57/122 (46%), Gaps = 2/122 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G + L LAV +++ LLS + G+T LH+A + ++ + L +
Sbjct: 547 GHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRH--GNTPLHVACKDGNMPIVVALCEANC 604
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+D +N G+TPLH+AA G +V+Y + A+ + +T LA H + L
Sbjct: 605 NLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGL 664
Query: 183 LA 184
LA
Sbjct: 665 LA 666
>X76104-1|CAA53712.1| 1431|Homo sapiens DAP-kinase protein.
Length = 1431
Score = 138 bits (335), Expect = 1e-31
Identities = 87/283 (30%), Positives = 147/283 (51%), Gaps = 7/283 (2%)
Query: 903 NDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEG 962
ND + H+ + + +N+ N G PLLIA G++Q++ L+ +R+DV D G
Sbjct: 353 NDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGG 412
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
+A++ AA HG++ L NK ++ K ++G ALH+AA G+A + + +
Sbjct: 413 SNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQVTCAASAQIP 472
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
T +++TPLH AA G V K L E G N++ + G+ P+ A+ Y ++V+ L
Sbjct: 473 ISRTKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVEC-L 531
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
+H + A KDG+ H+A + ++VI+ L+ G + +TPL +A +
Sbjct: 532 AEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLS---QGCFVDYQDRHGNTPLHVACKD 588
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMR 1185
G+ +V L A + N+ G T +HLAA +G +LDV+R
Sbjct: 589 GNMPIVVALCEANCNLDISNKYGRTPLHLAANNG---ILDVVR 628
Score = 123 bits (297), Expect = 6e-27
Identities = 89/306 (29%), Positives = 150/306 (49%), Gaps = 19/306 (6%)
Query: 1124 ISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDV 1183
++ NK + + PL +AA G+ ++++L++ G+ +++ G AV+ AA HGH + L
Sbjct: 372 VNQPNK-HGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKF 430
Query: 1184 MRSTNTLRISSK-KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAE 1242
+ S N + K K G LH+AA YG A+ + T + A +P+ +
Sbjct: 431 L-SENKCPLDVKDKSGEMALHVAARYGHADVAQV-------TCAASAQ-----IPISRTK 477
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRS 1302
TPLH AA++G +V + L AG + N G PL A G+ IV L
Sbjct: 478 EEETPLHCAAWHGYYSVAKALCE-AGCNVNI-KNREGETPLLTASARGYHDIVECLAEHG 535
Query: 1303 AELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVV 1362
A+L ++ D+ G LH+A ++++ LL QG ++ D++G TPLH A K G++ +V
Sbjct: 536 ADL-NACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIV 594
Query: 1363 KLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCS 1422
LCE+ + P+ AA+ DV+ YL ++L D + +L S
Sbjct: 595 VALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDL-ARS 653
Query: 1423 KNHNNI 1428
+ H ++
Sbjct: 654 EQHEHV 659
Score = 119 bits (287), Expect = 1e-25
Identities = 106/353 (30%), Positives = 160/353 (45%), Gaps = 21/353 (5%)
Query: 1055 IDATDELGQKPI-HAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIE 1113
+D D K I HA +N + L V K G IAA G++++++
Sbjct: 337 LDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQ 396
Query: 1114 ELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAA 1173
L+K R I ++K S + AA GH D ++ L ++++G A+H+AA
Sbjct: 397 LLIK--RGSRIDVQDK-GGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAA 453
Query: 1174 EHGHTNVLDVMRSTNT-LRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
+GH +V V + + + IS K TPLH AA++G + L EA
Sbjct: 454 RYGHADVAQVTCAASAQIPISRTKEEETPLHCAAWHGYYSVAKALC---------EAGCN 504
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHM 1292
V++ G TPL A+ G ++V L G +A +++G+ LHLA M
Sbjct: 505 VNIKN----REGETPLLTASARGYHDIVECLAEH-GADLNAC-DKDGHIALHLAVRRCQM 558
Query: 1293 SIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHC 1352
++ LLS+ + DRHG T LH+A G+ +V L ++ ++K G TPLH
Sbjct: 559 EVIKTLLSQGC-FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHL 617
Query: 1353 AAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
AA G L+VV+ LC GAS ++ T A SE H V L DT
Sbjct: 618 AANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDT 670
Score = 97.1 bits (231), Expect = 6e-19
Identities = 88/323 (27%), Positives = 142/323 (43%), Gaps = 33/323 (10%)
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMP 817
N+ + G P+ +AA GN+ L LL++ G +++ + D G + A R
Sbjct: 373 NQPNKHGTPPLLIAAGCGNIQILQLLIKRG------SRIDVQDK-GGSNAVYWAARHGHV 425
Query: 818 DIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIE 877
D ++ L E + +D D+ G ALH A + AD V C
Sbjct: 426 DTLKFLSE----------NKCPLDVKDKSGEMALHVAARYGH-------ADVAQVTCAAS 468
Query: 878 NGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIAC 937
A + + ET H A G V + + +N +N G TPLL A
Sbjct: 469 --AQIPISRTKEEETPLHCAAWHGYYSVAKAL------CEAGCNVNIKNREGETPLLTAS 520
Query: 938 HRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRT 997
RG+ +V L + A ++ D +G ALHLA ++V LL+ F++ + R+G T
Sbjct: 521 ARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNT 580
Query: 998 ALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDA 1057
LH+A +G +V L + N +D+ +TPLHLAA +G ++V + L +GA+++A
Sbjct: 581 PLHVACKDGNMPIVVALC-EANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEA 639
Query: 1058 TDELGQKPIHAAAQNNYSEVVQL 1080
G+ A + V L
Sbjct: 640 LTTDGKTAEDLARSEQHEHVAGL 662
Score = 93.5 bits (222), Expect = 7e-18
Identities = 71/264 (26%), Positives = 119/264 (45%), Gaps = 17/264 (6%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
ID D+ G++A+++A + + +K L EN + ++ + E A H A
Sbjct: 405 IDVQDKGGSNAVYWAARHGHVDT---------LKFLSENKCPLDVKDKSG-EMALHVAAR 454
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
G+ DV A + +SR + TPL A G+ + L V++ +
Sbjct: 455 YGHADVAQVTCAASAQIPISRTKEEE-----TPLHCAAWHGYYSVAKALCEAGCNVNIKN 509
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
EG + L A+ GY + + L + A +N+ ++G ALHLA ++K L+
Sbjct: 510 REGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLL-SQG 568
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
+D TPLH+A G + + L E N+D +++ G+ P+H AA N +VV+
Sbjct: 569 CFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVR 628
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIA 1103
+L V A T DG T +A
Sbjct: 629 -YLCLMGASVEALTTDGKTAEDLA 651
Score = 86.2 bits (204), Expect = 1e-15
Identities = 54/157 (34%), Positives = 76/157 (48%), Gaps = 3/157 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G+ PLL A G +V L A+ L A G ALHLA RR +++ + L+
Sbjct: 510 REGETPLLTASARGYHDIVECL--AEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ 567
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G VD + G TPLH+A +G+ P+V N I++ RTP+HLAA NG ++
Sbjct: 568 GCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVV 627
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
L AS+ T DG T +A H A +L
Sbjct: 628 RYLC-LMGASVEALTTDGKTAEDLARSEQHEHVAGLL 663
Score = 68.9 bits (161), Expect = 2e-10
Identities = 55/194 (28%), Positives = 81/194 (41%), Gaps = 18/194 (9%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G+ +++ AAR+GHV + L + +DV ALH+A V + A +
Sbjct: 412 GSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQVTCAASAQI 471
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
I K+ ETPLH AA A L ++G N +G TP+ A+ G +
Sbjct: 472 PISRTKEEETPLHCAA-WHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVEC 530
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
L E G D C D G L +A R C ++++ L+ F+D
Sbjct: 531 LAEHGAD----LNACDKD---GHIALHLAVRRCQMEVIKTLLS----------QGCFVDY 573
Query: 843 VDEDGASALHYACK 856
D G + LH ACK
Sbjct: 574 QDRHGNTPLHVACK 587
Score = 62.1 bits (144), Expect = 2e-08
Identities = 37/120 (30%), Positives = 64/120 (53%), Gaps = 4/120 (3%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ +G + TA+ G+ I+ L + G ++ D + ALH+AV C+ V++TLL
Sbjct: 508 KNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ 567
Query: 719 GADVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
G V + + TPLH+A + DG+ + L ++ + + + G TP+H+AA G L
Sbjct: 568 GCFVDYQ-DRHGNTPLHVACK--DGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGIL 624
Score = 59.3 bits (137), Expect = 1e-07
Identities = 44/174 (25%), Positives = 81/174 (46%), Gaps = 2/174 (1%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D+ + G++ L +A G+ V ++ A +A+ + T +T LH AA +A+
Sbjct: 439 DVKDKSGEMALHVAARYGHAD-VAQVTCAASAQIPISRTKEEETPLHCAAWHGYYSVAKA 497
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L + G V+ N G+TPL A+A G +V+ A+ D + +HLA
Sbjct: 498 LCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQ 557
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
+I+ L + + + + G+T +H+A +G+ + L + L + NKY
Sbjct: 558 MEVIKTLLSQ-GCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKY 610
Score = 57.6 bits (133), Expect = 4e-07
Identities = 47/159 (29%), Positives = 72/159 (45%), Gaps = 13/159 (8%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA +G+ + L + G +V++ + T L A +VE L +GAD++
Sbjct: 483 LHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACD 542
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
K LH+A R + LL G + G TP+HVA K GN+ +V L E
Sbjct: 543 -KDGHIALHLAVRRCQMEVIKT-LLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEA 600
Query: 787 GGDPLRKTKVCIYDVVT--GETPLQMACRSCMPDIVRHL 823
C D+ G TPL +A + + D+VR+L
Sbjct: 601 N---------CNLDISNKYGRTPLHLAANNGILDVVRYL 630
Score = 56.4 bits (130), Expect = 1e-06
Identities = 34/163 (20%), Positives = 73/163 (44%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
++ A+ N ++ LL + + + G L +AA ++ + ++L+ G+ +D
Sbjct: 348 IIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDV 407
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G ++ AA G +K+ + + D +H+AA GHA + ++
Sbjct: 408 QDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQVTCAA 467
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
RTK+ T +H A+ +G+ A L + G +++ N+
Sbjct: 468 SAQIPISRTKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNR 510
Score = 54.4 bits (125), Expect = 4e-06
Identities = 47/170 (27%), Positives = 71/170 (41%), Gaps = 14/170 (8%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVT-TNDNYTALHIAVESCKPAVVETLLG 717
K G ++H AARYGH + + ++ T + T LH A +V + L
Sbjct: 441 KDKSGEMALHVAARYGHADVAQVTCAASAQIPISRTKEEETPLHCAAWHGYYSVAKALCE 500
Query: 718 YGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
G +V+I+ ++ ETPL + A L + GA N +DG +H+A + +
Sbjct: 501 AGCNVNIK-NREGETPL-LTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQM 558
Query: 778 ATLVLLLEDGGDPLRKTKVCIYDVVT--GETPLQMACRSCMPDIVRHLIE 825
+ LL G C D G TPL +AC+ IV L E
Sbjct: 559 EVIKTLLSQG---------CFVDYQDRHGNTPLHVACKDGNMPIVVALCE 599
Score = 49.2 bits (112), Expect = 2e-04
Identities = 34/122 (27%), Positives = 57/122 (46%), Gaps = 2/122 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G + L LAV +++ LLS + G+T LH+A + ++ + L +
Sbjct: 545 GHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRH--GNTPLHVACKDGNMPIVVALCEANC 602
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+D +N G+TPLH+AA G +V+Y + A+ + +T LA H + L
Sbjct: 603 NLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGL 662
Query: 183 LA 184
LA
Sbjct: 663 LA 664
>Y10601-1|CAA71610.1| 1119|Homo sapiens ankyrin-like protein protein.
Length = 1119
Score = 138 bits (333), Expect = 3e-31
Identities = 135/535 (25%), Positives = 252/535 (47%), Gaps = 41/535 (7%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA-D 721
G +H A + + LL +G + ++ + LHIAV+ V++ LL + D
Sbjct: 98 GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTID 157
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V++ G + T + IA + + ++L K GA P K+ + G P+H AA G+ +
Sbjct: 158 VNLEG-ENGNTAVIIACTTNNSEALQILLNK-GAKPCKSNKWGCFPIHQAAFSGSKECME 215
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGE-TPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFI 840
++L G + ++ I + G+ TPL +A ++ ++++ ++ + A I
Sbjct: 216 IILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLD----------NGAQI 265
Query: 841 DAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIA 900
D V++ +A+H+A E+ +++ D+ T HET H ++
Sbjct: 266 DPVEKGRCTAIHFAATQGATEIV------KLMISSYSGSVDIVNTTDGCHETMLHRASLF 319
Query: 901 GNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDV 960
++++ +I+ V +N+ +S G +PL++A +VN LL+ A+VD+ D
Sbjct: 320 DHHELADYLIS------VGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDN 373
Query: 961 EGRSALHLAAE--HGYLQVCDALLTN---KAFINSKARNGRTALHLAAMNGYAHLVKFLI 1015
GR+ LHL + +G + + K + + +G T LH A G V L+
Sbjct: 374 FGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLL 433
Query: 1016 RDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN---IDATDELGQKPIHAAAQN 1072
N I + K++PLH AA+ G+I C+ LL+ ++ ++ D G P+H AA+N
Sbjct: 434 -GFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKN 492
Query: 1073 NYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLND 1132
+ +VVQL L++ + + +G T H A++ G + ++ ++ D + R +
Sbjct: 493 GHDKVVQLLLKK--GALFLSDHNGWTALHHASMGGYTQTMKVIL--DTNLKCTDRLDEDG 548
Query: 1133 STPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTN-VLDVMRS 1186
+T L AA GHA V +L+ A N+ + +HLA + VL ++RS
Sbjct: 549 NTALHFAAREGHAKAVALLLSHNADIV-LNKQQASFLHLALHNKRKEVVLTIIRS 602
Score = 135 bits (326), Expect = 2e-30
Identities = 138/537 (25%), Positives = 240/537 (44%), Gaps = 35/537 (6%)
Query: 884 LQTRHNHETAF-HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
L+T + +T F HY A G ++M E I S+ +V L+ + G TPL A + +
Sbjct: 56 LKTCDDMDTFFLHYAAAEGQIELM-EKITRDSSLEV---LHEMDDYGNTPLHCAVEKNQI 111
Query: 943 QLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHL 1001
+ V LL+ A ++ + + LH+A + +V LL ++ +N + NG TA+ +
Sbjct: 112 ESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVII 171
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELG--------A 1053
A + ++ L+ + A P+H AA SG E +++L G
Sbjct: 172 ACTTNNSEALQILL-NKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQL 230
Query: 1054 NIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIE 1113
+I+ + P+H A QN E++++ L + K T H AA QG+ +++
Sbjct: 231 HINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQ-IDPVEKGRCTAIHFAATQGATEIV- 288
Query: 1114 ELMKFDRTGVISARNKLN--DSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHL 1171
+LM +G + N + T L A+ H ++ L+ GA + G + + L
Sbjct: 289 KLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLIL 348
Query: 1172 AAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT 1231
A N+++++ S G LH+ Q ++ L P ++ +
Sbjct: 349 ATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQ--QPYGLKNLR---PEFMQMQQ-- 401
Query: 1232 GVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGH 1291
+ + + G TPLH A G V LL V + S + +PLH A G
Sbjct: 402 -IKELVMDEDNDGCTPLHYACRQGGPGSVNNLL-GFNVSIHSKSKDK-KSPLHFAASYGR 458
Query: 1292 MSIVGLLLS--RSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP 1349
++ LL LL+ D HG T LH+A+ +GH ++V++LL +GA + +D NGWT
Sbjct: 459 INTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTA 517
Query: 1350 LHCAAKAGHLNVVKLLCESG--ASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
LH A+ G+ +K++ ++ + + + + N A + FAA E H + LL D
Sbjct: 518 LHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTA-LHFAAREGHAKAVALLLSHNAD 573
Score = 130 bits (315), Expect = 4e-29
Identities = 167/628 (26%), Positives = 267/628 (42%), Gaps = 62/628 (9%)
Query: 923 NRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV-FDVE-GRSALHLAAEHGYLQVCDA 980
N +N PL IA + +++ LL H +DV + E G +A+ +A +
Sbjct: 125 NLRNFNMMAPLHIAVQGMNNEVMKVLL-EHRTIDVNLEGENGNTAVIIACTTNNSEALQI 183
Query: 981 LLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIR---DHNAM----IDVLTLKKQTPL 1033
LL A + G +H AA +G ++ ++R +H I+ + K TPL
Sbjct: 184 LLNKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPL 243
Query: 1034 HLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV-MAT 1092
HLA +G +E+ K+ L+ GA ID ++ IH AA +E+V+L + + V +
Sbjct: 244 HLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVN 303
Query: 1093 TKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDS--TPLQLAAEGGHADVVRV 1150
T DG C + S+ EL + V + NK++ +PL LA ++V +
Sbjct: 304 TTDG--CHETMLHRASLFDHHELADY-LISVGADINKIDSEGRSPLILATASASWNIVNL 360
Query: 1151 LVRAGASCTDENRAGLTAVHLAAE--HGHTNVLDV---MRSTNTLRISSKKLGLTPLHIA 1205
L+ GA ++ G +HL + +G N+ M+ L + G TPLH A
Sbjct: 361 LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA 420
Query: 1206 AYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVV-RLLL 1264
G PG+V + VS+ ++ +PLH AA G N RLL
Sbjct: 421 CRQGG-----------PGSVNNLLGFNVSIHSK--SKDKKSPLHFAASYGRINTCQRLLQ 467
Query: 1265 NSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHG 1324
+ + + + +G PLHLA GH +V LLL + A L +D +G T LH AS G
Sbjct: 468 DISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFL--SDHNGWTALHHASMGG 525
Query: 1325 HYQMVEVLLGQGAEI-NATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPI 1383
+ Q ++V+L + + D++G T LH AA+ GH V LL S ++ LN
Sbjct: 526 YTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALL----LSHNADIVLNKQQA 581
Query: 1384 WFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNH--NNIPIEEFVLVSPAPV 1441
F HN E +L +++ KR+ L + S N N PI E + P +
Sbjct: 582 SFLHLALHNKRKEVVL-------TIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECM 634
Query: 1442 DTAAKLSNIYINLSTKEKERAKDLIAAGKQCEXXXXXXXXXXXXXDSAGHILTATDNRNI 1501
++ ST++K I + D LTA
Sbjct: 635 KVLLDFCMLH---STEDKSCRDYYIEYNFKYLQCPLEFTKKTPTQDVIYEPLTA------ 685
Query: 1502 EFLDVLIENEQKEVIAHTVVQRYLQELW 1529
L+ +++N + E++ H V + YL W
Sbjct: 686 --LNAMVQNNRIELLNHPVCKEYLLMKW 711
Score = 53.6 bits (123), Expect = 7e-06
Identities = 41/160 (25%), Positives = 75/160 (46%), Gaps = 10/160 (6%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL +AV+ N +++ LL +T + + G+TA+ +A + + +IL++ GA
Sbjct: 134 PLHIAVQGMNNEVMKVLLEHRTID-VNLEGENGNTAVIIACTTNNSEALQILLNKGAKPC 192
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYF--------YGVRANAAIADNEDRTPMHLAAENGHA 177
+N G P+H AA G + ++ Y + + +N TP+HLA +NG
Sbjct: 193 KSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDL 252
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+I++ D A I K T +H A+ G + ++
Sbjct: 253 EMIKMCLDN-GAQIDPVEKGRCTAIHFAATQGATEIVKLM 291
Score = 53.6 bits (123), Expect = 7e-06
Identities = 47/180 (26%), Positives = 77/180 (42%), Gaps = 7/180 (3%)
Query: 41 LNKERAKQKEWKKLIRDLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDT 100
L E + ++ K+L+ D G PL A G V LL + K+ +
Sbjct: 392 LRPEFMQMQQIKELVMD-EDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKK--S 448
Query: 101 ALHLAARRRDVDMA-RILVDYGAVVDATNGA--GQTPLHIAAAEGDEPLVKYFYGVRANA 157
LH AA ++ R+L D G G TPLH+AA G + +V+ A
Sbjct: 449 PLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-L 507
Query: 158 AIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
++D+ T +H A+ G+ ++++ D +DG+T +H A+ GHA +L
Sbjct: 508 FLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALL 567
Score = 52.4 bits (120), Expect = 2e-05
Identities = 46/167 (27%), Positives = 74/167 (44%), Gaps = 11/167 (6%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARR----RDV--DMARI 116
G+ PL+LA + + ++V LLS +K G LHL ++ +++ + ++
Sbjct: 342 GRSPLILATASASWNIVNLLLSKGAQVDIKDNF--GRNFLHLTVQQPYGLKNLRPEFMQM 399
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
V+D N G TPLH A +G V G + + ++P+H AA G
Sbjct: 400 QQIKELVMDEDND-GCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGR 458
Query: 177 AAIIE-LLADKFKASIF-ERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ LL D + E G T +H+A+ NGH +L KKG
Sbjct: 459 INTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKG 505
Score = 52.0 bits (119), Expect = 2e-05
Identities = 39/126 (30%), Positives = 59/126 (46%), Gaps = 4/126 (3%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DG +H A R G G +N LL S+ + D + LH A + + LL +D
Sbjct: 412 DGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISD 471
Query: 722 VHI--RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
+ G TPLH+AA+ DK +LLK GA + +G T +H A+ G T
Sbjct: 472 TRLLNEGDLHGMTPLHLAAK-NGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQT 529
Query: 780 LVLLLE 785
+ ++L+
Sbjct: 530 MKVILD 535
Score = 45.6 bits (103), Expect = 0.002
Identities = 33/144 (22%), Positives = 63/144 (43%), Gaps = 2/144 (1%)
Query: 89 EQLKATTPAGDTALHLAARRRDVD-MARILVDYGA-VVDATNGAGQTPLHIAAAEGDEPL 146
++LK LH AA ++ M +I D V+ + G TPLH A +
Sbjct: 54 KKLKTCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIES 113
Query: 147 VKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIAS 206
VK+ AN + + P+H+A + + ++++L + + ++G+T + IA
Sbjct: 114 VKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIAC 173
Query: 207 LNGHADCAMMLFKKGVYLHMPNKY 230
+++ +L KG NK+
Sbjct: 174 TTNNSEALQILLNKGAKPCKSNKW 197
Score = 45.2 bits (102), Expect = 0.003
Identities = 39/168 (23%), Positives = 70/168 (41%), Gaps = 10/168 (5%)
Query: 70 AVEAGNQSMVRELLSAQTA--EQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDAT 127
A G +V+ ++S+ + + + T +T LH A+ ++A L+ GA ++
Sbjct: 279 AATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKI 338
Query: 128 NGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKF 187
+ G++PL +A A +V A I DN R +HL + + ++ L +F
Sbjct: 339 DSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYG--LKNLRPEF 396
Query: 188 ------KASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
K + + DG T +H A G L V +H +K
Sbjct: 397 MQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSK 444
Score = 44.8 bits (101), Expect = 0.003
Identities = 33/153 (21%), Positives = 66/153 (43%), Gaps = 2/153 (1%)
Query: 70 AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNG 129
A G ++ ++ + E L G+T LH A + ++ + L+ GA + N
Sbjct: 70 AAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNF 129
Query: 130 AGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED-RTPMHLAAENGHAAIIELLADKFK 188
PLHIA + ++K R + E+ T + +A ++ +++L +K
Sbjct: 130 NMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLNK-G 188
Query: 189 ASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
A + K G +H A+ +G +C ++ + G
Sbjct: 189 AKPCKSNKWGCFPIHQAAFSGSKECMEIILRFG 221
Score = 44.8 bits (101), Expect = 0.003
Identities = 32/135 (23%), Positives = 62/135 (45%), Gaps = 5/135 (3%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAA- 158
T LHLA + D++M ++ +D GA +D T +H AA +G +VK + +
Sbjct: 241 TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD 300
Query: 159 IADNED---RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAM 215
I + D T +H A+ H + + L A I + +G + + +A+ + +
Sbjct: 301 IVNTTDGCHETMLHRASLFDHHELADYLI-SVGADINKIDSEGRSPLILATASASWNIVN 359
Query: 216 MLFKKGVYLHMPNKY 230
+L KG + + + +
Sbjct: 360 LLLSKGAQVDIKDNF 374
Score = 40.3 bits (90), Expect = 0.072
Identities = 37/134 (27%), Positives = 55/134 (41%), Gaps = 5/134 (3%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDN---YTALHIAVESCKPAVVETL 715
K D +H AA YG + LLQ + + T LH+A ++ VV+ L
Sbjct: 442 KSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLL 501
Query: 716 LGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
L GA T LH A+ ++L + ++ EDG T +H AA+ G
Sbjct: 502 LKKGA--LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREG 559
Query: 776 NLATLVLLLEDGGD 789
+ + LLL D
Sbjct: 560 HAKAVALLLSHNAD 573
>BC127127-1|AAI27128.1| 627|Homo sapiens ankyrin repeat and KH domain
containing 1 protein.
Length = 627
Score = 134 bits (324), Expect = 3e-30
Identities = 119/411 (28%), Positives = 184/411 (44%), Gaps = 22/411 (5%)
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
V+ RS L A G + LL +N G + L LA GY L + L+ H
Sbjct: 204 VDTRS-LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 262
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
+ D TPL A++ G +++ KLLL A++++ G + A + ++V+
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLA 1139
+ L + N + ++G+T AA G V+V L+ G+ + N+ +S L LA
Sbjct: 323 VLLNEGAN-IEDHNENGHTPLMEAASAGHVEVARVLLDHG-AGINTHSNEFKESA-LTLA 379
Query: 1140 AEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGL 1199
GH D+VR L+ AGA + TA+ A GH V ++ +
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
+PL +AA G E L+ G +L V + G TPL AA G+E +
Sbjct: 440 SPLTLAACGGHVELAALLIER-----------GANLEEV--NDEGYTPLMEAAREGHEEM 486
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
V LLL + G +A + E L LAC GG + L+ A++ + T L
Sbjct: 487 VALLL-AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI----ELGCSTPLME 541
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
AS GH ++V+ LL GA ++AT G T L A + GH +V +L ++GA
Sbjct: 542 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 592
Score = 131 bits (317), Expect = 2e-29
Identities = 120/413 (29%), Positives = 189/413 (45%), Gaps = 25/413 (6%)
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A +G + V+ L+ D ++ T + ++ L LA ++G E+ ++LL + AN++
Sbjct: 212 ACSDGDVNAVRKLL-DEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 270
Query: 1062 GQ-KPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDR 1120
G P+ AA+ Y ++V+L L H V + + GNT A G V +++ L+ +
Sbjct: 271 GDITPLMAASSGGYLDIVKLLLL-HDADVNSQSATGNTALTYACAGGFVDIVKVLL--NE 327
Query: 1121 TGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASC-TDENRAGLTAVHLAAEHGHTN 1179
I N+ N TPL AA GH +V RVL+ GA T N +A+ LA GH +
Sbjct: 328 GANIEDHNE-NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386
Query: 1180 VLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVL 1239
++ + + T L A G E R LL +G + +
Sbjct: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD-----------SGAQVN--M 433
Query: 1240 GAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLL 1299
A+S +PL LAA G+ + LL+ G + N+ GY PL A GH +V LLL
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIER-GANLEEV-NDEGYTPLMEAAREGHEEMVALLL 491
Query: 1300 SRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
++ A + T+ +T L +A G ++ + L+ GA+I TPL A++ GHL
Sbjct: 492 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHL 548
Query: 1360 NVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDK 1412
+VK L SGA+ + T + +A H DV + LL D D K
Sbjct: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 601
Score = 122 bits (295), Expect = 1e-26
Identities = 115/408 (28%), Positives = 179/408 (43%), Gaps = 27/408 (6%)
Query: 936 ACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNG 995
AC G + V LL V+ EG S L LA GY ++ LL A + + G
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 996 R-TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
T L A+ GY +VK L+ H+A ++ + T L A A G +++ K+LL GAN
Sbjct: 272 DITPLMAASSGGYLDIVKLLLL-HDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 330
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
I+ +E G P+ AA + EV ++ L + + + + +A +G + ++
Sbjct: 331 IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRF 390
Query: 1115 LMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
L++ G T L A GH +V R+L+ +GA + + + LAA
Sbjct: 391 LLE---AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447
Query: 1175 HGHTNV--LDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
GH + L + R N ++ + G TPL AA G E V LL+ G
Sbjct: 448 GGHVELAALLIERGANLEEVNDE--GYTPLMEAAREGHEEMVALLLAQ-----------G 494
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHM 1292
+ + E+ T L LA G V L+ AG + + PL A GH+
Sbjct: 495 AN-INAQTEETQETALTLACCGGFSEVADFLI-KAGADIELGCS----TPLMEASQEGHL 548
Query: 1293 SIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN 1340
+V LL+ A +H+T G T L A +GH + +VLL GA+++
Sbjct: 549 ELVKYLLASGAN-VHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
Score = 109 bits (262), Expect = 1e-22
Identities = 120/425 (28%), Positives = 189/425 (44%), Gaps = 38/425 (8%)
Query: 665 RSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHI 724
RS+ A G V + LL +G SV+ T + + L +A + + + LL A+V
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 266
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLL 784
RG K TPL A+ D L+LL A N + G T + A G + + +LL
Sbjct: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHD-ADVNSQSATGNTALTYACAGGFVDIVKVLL 325
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD 844
+G + + G TPL A + ++ R L+ DH G ++T +
Sbjct: 326 NEGANIEDHNE-------NGHTPLMEAASAGHVEVARVLL----DH-GAGINT----HSN 369
Query: 845 EDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNND 904
E SAL AC +V+ L+E GAD +T H TA + G+ +
Sbjct: 370 EFKESALTLACY---------KGHLDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVE 419
Query: 905 VMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRS 964
V ++ D +N +PL +A GH++L L+ A ++ + EG +
Sbjct: 420 VARLLL------DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYT 473
Query: 965 ALHLAAEHGYLQVCDALLTNKAFINSKARNGR-TALHLAAMNGYAHLVKFLIRDHNAMID 1023
L AA G+ ++ LL A IN++ + TAL LA G++ + FLI+ A D
Sbjct: 474 PLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIK---AGAD 530
Query: 1024 VLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
+ L TPL A+ G +E+ K LL GAN+ AT G + A +N +++V + LQ
Sbjct: 531 I-ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589
Query: 1084 QHPNL 1088
+L
Sbjct: 590 AGADL 594
Score = 107 bits (258), Expect = 3e-22
Identities = 101/382 (26%), Positives = 165/382 (43%), Gaps = 28/382 (7%)
Query: 1132 DSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT-L 1190
D+ L A G + VR L+ G S + G + + LA G+ + V+ + + +
Sbjct: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG------------VSLVPV 1238
K +TPL A+ G + V+ LL H V S++ TG V +V V
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLH-DADVNSQSATGNTALTYACAGGFVDIVKV 323
Query: 1239 L---GA------ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFG 1289
L GA E+G TPL AA G+ V R+LL+ G + SNE + L LAC+
Sbjct: 324 LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH-GAGINTHSNEFKESALTLACYK 382
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP 1349
GH+ +V LL A+ H TD T L A GH ++ +LL GA++N + +P
Sbjct: 383 GHLDMVRFLLEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 441
Query: 1350 LHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLM 1409
L AA GH+ + LL E GA+ + + P+ AA E H +++ LL + + +
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
Query: 1410 DDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKERAKDLIAAG 1469
++ + + C + + +F++ + A ++ + + E K L+A+G
Sbjct: 502 EETQETALTLACCGGFSE--VADFLIKAGADIELGCSTPLMEAS-QEGHLELVKYLLASG 558
Query: 1470 KQCEXXXXXXXXXXXXXDSAGH 1491
GH
Sbjct: 559 ANVHATTATGDTALTYACENGH 580
Score = 101 bits (242), Expect = 3e-20
Identities = 118/425 (27%), Positives = 190/425 (44%), Gaps = 45/425 (10%)
Query: 736 IAARIPDGDKCALM-LLKSGAGPNKATEDGMTPVHVAAKFG--NLATLVLLLEDGGDPLR 792
+A DGD A+ LL G N+ TE+G + + +A G LA ++L + + R
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED-R 267
Query: 793 KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALH 852
K I TPL A DIV+ L+ D +S + G +AL
Sbjct: 268 GNKGDI-------TPLMAASSGGYLDIVKLLLLHDADVNSQSAT----------GNTALT 310
Query: 853 YACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAH 912
YAC ++ VK L+ GA++ + H T A AG+ +V ++ H
Sbjct: 311 YACAGGFVDI---------VKVLLNEGANIEDHNENGH-TPLMEAASAGHVEVARVLLDH 360
Query: 913 ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEH 972
A ++ N + L +AC++GH+ +V LL A + E +AL A
Sbjct: 361 --GAGIN---THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 415
Query: 973 GYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTP 1032
G+++V LL + A +N A + + L LAA G+ L LI + A ++ + + TP
Sbjct: 416 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI-ERGANLEEVNDEGYTP 474
Query: 1033 LHLAAASGQIEVCKLLLELGANIDA-TDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
L AA G E+ LLL GANI+A T+E + + A +SEV ++ ++ +
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG 534
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
+T A+ +G +++++ L+ +G T L A E GH DV VL
Sbjct: 535 C----STPLMEASQEGHLELVKYLL---ASGANVHATTATGDTALTYACENGHTDVADVL 587
Query: 1152 VRAGA 1156
++AGA
Sbjct: 588 LQAGA 592
Score = 64.1 bits (149), Expect = 5e-09
Identities = 46/172 (26%), Positives = 82/172 (47%), Gaps = 3/172 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G + L+A +G + +LL A+ + + + G+TAL A VD+ ++L++ G
Sbjct: 270 KGDITPLMAASSGGYLDIVKLLLLHDAD-VNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAAENGHAAII 180
A ++ N G TPL AA+ G + + A NE + + + LA GH ++
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFE 232
L + A +T + T + A ++GH + A +L G ++MP FE
Sbjct: 389 RFLLEA-GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
Score = 62.1 bits (144), Expect = 2e-08
Identities = 51/161 (31%), Positives = 79/161 (49%), Gaps = 4/161 (2%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G+ MVR LL A ++ K T TAL A V++AR+L+D GA V+
Sbjct: 376 LTLACYKGHLDMVRFLLEAGADQEHK--TDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ ++PL +AA G L AN ++E TP+ AA GH ++ LL +
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Query: 187 FKASIFERTKD-GSTLMHIASLNGHADCAMMLFKKGVYLHM 226
A+I +T++ T + +A G ++ A L K G + +
Sbjct: 494 -GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL 533
Score = 53.6 bits (123), Expect = 7e-06
Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 2/165 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL+ A AG+ + R LL + ++AL LA + +DM R L++
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNE-FKESALTLACYKGHLDMVRFLLEA 394
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA + T L A +G + + A + + +P+ LAA GH +
Sbjct: 395 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 454
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
LL ++ A++ E +G T + A+ GH + +L +G ++
Sbjct: 455 ALLIER-GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Score = 52.8 bits (121), Expect = 1e-05
Identities = 48/194 (24%), Positives = 87/194 (44%), Gaps = 13/194 (6%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA GHV + L+++G +++ ++ YT L A +V LL GA+++ + +
Sbjct: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
+ET L +A + A L+K+GA TP+ A++ G+L + LL G +
Sbjct: 505 QETALTLAC-CGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGAN 560
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD--EDG 847
T TG+T L AC + D+ L++ D + ++ +D +
Sbjct: 561 VHATT-------ATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDPAKHQ 613
Query: 848 ASALHYACKVTKEE 861
ACK+ ++E
Sbjct: 614 VRVAFDACKLLRKE 627
Score = 52.4 bits (120), Expect = 2e-05
Identities = 42/125 (33%), Positives = 56/125 (44%), Gaps = 4/125 (3%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V G PL+ A G++ MV LL AQ A T +TAL LA ++A L+
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVA-LLLAQGANINAQTEETQETALTLACCGGFSEVADFLI 525
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
GA ++ TPL A+ EG LVKY AN T + A ENGH
Sbjct: 526 KAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTD 582
Query: 179 IIELL 183
+ ++L
Sbjct: 583 VADVL 587
Score = 51.6 bits (118), Expect = 3e-05
Identities = 45/160 (28%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G+ + L+ + L+ G T L AAR +M +L+ GA ++
Sbjct: 441 PLTLAACGGHVELAALLI--ERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Query: 126 A-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A T +T L +A G + + ++A A I + TP+ A++ GH +++ L
Sbjct: 499 AQTEETQETALTLACCGGFSEVADFL--IKAGADI-ELGCSTPLMEASQEGHLELVKYLL 555
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
A++ T G T + A NGH D A +L + G L
Sbjct: 556 AS-GANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/162 (25%), Positives = 68/162 (41%), Gaps = 3/162 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGD-TALHLAARRRDVDMARILVD 119
+ G+ L LA AG + + LL+ + + GD T L A+ +D+ ++L+
Sbjct: 236 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK--GDITPLMAASSGGYLDIVKLLLL 293
Query: 120 YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
+ A V++ + G T L A A G +VK AN + TP+ AA GH +
Sbjct: 294 HDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEV 353
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+L D + + + +A GH D L + G
Sbjct: 354 ARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
Score = 45.6 bits (103), Expect = 0.002
Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 2/121 (1%)
Query: 110 DVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE-DRTPM 168
DV+ R L+D G V+ G++ L +A + G L + + AN N+ D TP+
Sbjct: 217 DVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPL 276
Query: 169 HLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
A+ G+ I++LL A + ++ G+T + A G D +L +G + N
Sbjct: 277 MAASSGGYLDIVKLLL-LHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 229 K 229
+
Sbjct: 336 E 336
Score = 41.5 bits (93), Expect = 0.031
Identities = 38/130 (29%), Positives = 62/130 (47%), Gaps = 8/130 (6%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY-TALHIAVESCKPAVVETLLGYGA 720
+G + AAR GH ++ LL +G +++ T + TAL +A V + L+ GA
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529
Query: 721 DVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
D+ + TPL A++ +G + LL SGA + T G T + A + G+
Sbjct: 530 DIEL----GCSTPLMEASQ--EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 583
Query: 780 LVLLLEDGGD 789
+LL+ G D
Sbjct: 584 ADVLLQAGAD 593
Score = 38.3 bits (85), Expect = 0.29
Identities = 22/60 (36%), Positives = 34/60 (56%), Gaps = 2/60 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL+ A + G+ +V+ LL++ + ATT GDTAL A D+A +L+ GA +D
Sbjct: 538 PLMEASQEGHLELVKYLLAS--GANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
Score = 37.9 bits (84), Expect = 0.39
Identities = 28/111 (25%), Positives = 49/111 (44%), Gaps = 1/111 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
L AE H+ + L A + G V LL +G +N + G + L A AG
Sbjct: 190 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 249
Query: 1358 HLNVVKLLCESGASPKSETNL-NCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
+ + ++L A+ + N + P+ A+S + D+++ LL + D S
Sbjct: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
>BC117677-1|AAI17678.1| 627|Homo sapiens ankyrin repeat and KH domain
containing 1 protein.
Length = 627
Score = 134 bits (324), Expect = 3e-30
Identities = 119/411 (28%), Positives = 184/411 (44%), Gaps = 22/411 (5%)
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
V+ RS L A G + LL +N G + L LA GY L + L+ H
Sbjct: 204 VDTRS-LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 262
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
+ D TPL A++ G +++ KLLL A++++ G + A + ++V+
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLA 1139
+ L + N + ++G+T AA G V+V L+ G+ + N+ +S L LA
Sbjct: 323 VLLNEGAN-IEDHNENGHTPLMEAASAGHVEVARVLLDHG-AGINTHSNEFKESA-LTLA 379
Query: 1140 AEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGL 1199
GH D+VR L+ AGA + TA+ A GH V ++ +
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
+PL +AA G E L+ G +L V + G TPL AA G+E +
Sbjct: 440 SPLTLAACGGHVELAALLIER-----------GANLEEV--NDEGYTPLMEAAREGHEEM 486
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
V LLL + G +A + E L LAC GG + L+ A++ + T L
Sbjct: 487 VALLL-AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI----ELGCSTPLME 541
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
AS GH ++V+ LL GA ++AT G T L A + GH +V +L ++GA
Sbjct: 542 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 592
Score = 131 bits (317), Expect = 2e-29
Identities = 120/413 (29%), Positives = 189/413 (45%), Gaps = 25/413 (6%)
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A +G + V+ L+ D ++ T + ++ L LA ++G E+ ++LL + AN++
Sbjct: 212 ACSDGDVNAVRKLL-DEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 270
Query: 1062 GQ-KPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDR 1120
G P+ AA+ Y ++V+L L H V + + GNT A G V +++ L+ +
Sbjct: 271 GDITPLMAASSGGYLDIVKLLLL-HDADVNSQSATGNTALTYACAGGFVDIVKVLL--NE 327
Query: 1121 TGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASC-TDENRAGLTAVHLAAEHGHTN 1179
I N+ N TPL AA GH +V RVL+ GA T N +A+ LA GH +
Sbjct: 328 GANIEDHNE-NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386
Query: 1180 VLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVL 1239
++ + + T L A G E R LL +G + +
Sbjct: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD-----------SGAQVN--M 433
Query: 1240 GAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLL 1299
A+S +PL LAA G+ + LL+ G + N+ GY PL A GH +V LLL
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIER-GANLEEV-NDEGYTPLMEAAREGHEEMVALLL 491
Query: 1300 SRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
++ A + T+ +T L +A G ++ + L+ GA+I TPL A++ GHL
Sbjct: 492 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHL 548
Query: 1360 NVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDK 1412
+VK L SGA+ + T + +A H DV + LL D D K
Sbjct: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 601
Score = 122 bits (295), Expect = 1e-26
Identities = 115/408 (28%), Positives = 179/408 (43%), Gaps = 27/408 (6%)
Query: 936 ACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNG 995
AC G + V LL V+ EG S L LA GY ++ LL A + + G
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 996 R-TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
T L A+ GY +VK L+ H+A ++ + T L A A G +++ K+LL GAN
Sbjct: 272 DITPLMAASSGGYLDIVKLLLL-HDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 330
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
I+ +E G P+ AA + EV ++ L + + + + +A +G + ++
Sbjct: 331 IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRF 390
Query: 1115 LMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
L++ G T L A GH +V R+L+ +GA + + + LAA
Sbjct: 391 LLE---AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447
Query: 1175 HGHTNV--LDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
GH + L + R N ++ + G TPL AA G E V LL+ G
Sbjct: 448 GGHVELAALLIERGANLEEVNDE--GYTPLMEAAREGHEEMVALLLAQ-----------G 494
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHM 1292
+ + E+ T L LA G V L+ AG + + PL A GH+
Sbjct: 495 AN-INAQTEETQETALTLACCGGFSEVADFLI-KAGADIELGCS----TPLMEASQEGHL 548
Query: 1293 SIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN 1340
+V LL+ A +H+T G T L A +GH + +VLL GA+++
Sbjct: 549 ELVKYLLASGAN-VHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
Score = 109 bits (262), Expect = 1e-22
Identities = 120/425 (28%), Positives = 189/425 (44%), Gaps = 38/425 (8%)
Query: 665 RSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHI 724
RS+ A G V + LL +G SV+ T + + L +A + + + LL A+V
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 266
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLL 784
RG K TPL A+ D L+LL A N + G T + A G + + +LL
Sbjct: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHD-ADVNSQSATGNTALTYACAGGFVDIVKVLL 325
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD 844
+G + + G TPL A + ++ R L+ DH G ++T +
Sbjct: 326 NEGANIEDHNE-------NGHTPLMEAASAGHVEVARVLL----DH-GAGINT----HSN 369
Query: 845 EDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNND 904
E SAL AC +V+ L+E GAD +T H TA + G+ +
Sbjct: 370 EFKESALTLACY---------KGHLDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVE 419
Query: 905 VMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRS 964
V ++ D +N +PL +A GH++L L+ A ++ + EG +
Sbjct: 420 VARLLL------DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYT 473
Query: 965 ALHLAAEHGYLQVCDALLTNKAFINSKARNGR-TALHLAAMNGYAHLVKFLIRDHNAMID 1023
L AA G+ ++ LL A IN++ + TAL LA G++ + FLI+ A D
Sbjct: 474 PLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIK---AGAD 530
Query: 1024 VLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
+ L TPL A+ G +E+ K LL GAN+ AT G + A +N +++V + LQ
Sbjct: 531 I-ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589
Query: 1084 QHPNL 1088
+L
Sbjct: 590 AGADL 594
Score = 107 bits (258), Expect = 3e-22
Identities = 101/382 (26%), Positives = 165/382 (43%), Gaps = 28/382 (7%)
Query: 1132 DSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT-L 1190
D+ L A G + VR L+ G S + G + + LA G+ + V+ + + +
Sbjct: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG------------VSLVPV 1238
K +TPL A+ G + V+ LL H V S++ TG V +V V
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLH-DADVNSQSATGNTALTYACAGGFVDIVKV 323
Query: 1239 L---GA------ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFG 1289
L GA E+G TPL AA G+ V R+LL+ G + SNE + L LAC+
Sbjct: 324 LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH-GAGINTHSNEFKESALTLACYK 382
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP 1349
GH+ +V LL A+ H TD T L A GH ++ +LL GA++N + +P
Sbjct: 383 GHLDMVRFLLEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 441
Query: 1350 LHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLM 1409
L AA GH+ + LL E GA+ + + P+ AA E H +++ LL + + +
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
Query: 1410 DDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKERAKDLIAAG 1469
++ + + C + + +F++ + A ++ + + E K L+A+G
Sbjct: 502 EETQETALTLACCGGFSE--VADFLIKAGADIELGCSTPLMEAS-QEGHLELVKYLLASG 558
Query: 1470 KQCEXXXXXXXXXXXXXDSAGH 1491
GH
Sbjct: 559 ANVHATTATGDTALTYACENGH 580
Score = 101 bits (242), Expect = 3e-20
Identities = 118/425 (27%), Positives = 190/425 (44%), Gaps = 45/425 (10%)
Query: 736 IAARIPDGDKCALM-LLKSGAGPNKATEDGMTPVHVAAKFG--NLATLVLLLEDGGDPLR 792
+A DGD A+ LL G N+ TE+G + + +A G LA ++L + + R
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED-R 267
Query: 793 KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALH 852
K I TPL A DIV+ L+ D +S + G +AL
Sbjct: 268 GNKGDI-------TPLMAASSGGYLDIVKLLLLHDADVNSQSAT----------GNTALT 310
Query: 853 YACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAH 912
YAC ++ VK L+ GA++ + H T A AG+ +V ++ H
Sbjct: 311 YACAGGFVDI---------VKVLLNEGANIEDHNENGH-TPLMEAASAGHVEVARVLLDH 360
Query: 913 ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEH 972
A ++ N + L +AC++GH+ +V LL A + E +AL A
Sbjct: 361 --GAGIN---THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 415
Query: 973 GYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTP 1032
G+++V LL + A +N A + + L LAA G+ L LI + A ++ + + TP
Sbjct: 416 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI-ERGANLEEVNDEGYTP 474
Query: 1033 LHLAAASGQIEVCKLLLELGANIDA-TDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
L AA G E+ LLL GANI+A T+E + + A +SEV ++ ++ +
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG 534
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
+T A+ +G +++++ L+ +G T L A E GH DV VL
Sbjct: 535 C----STPLMEASQEGHLELVKYLL---ASGANVHATTATGDTALTYACENGHTDVADVL 587
Query: 1152 VRAGA 1156
++AGA
Sbjct: 588 LQAGA 592
Score = 64.1 bits (149), Expect = 5e-09
Identities = 46/172 (26%), Positives = 82/172 (47%), Gaps = 3/172 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G + L+A +G + +LL A+ + + + G+TAL A VD+ ++L++ G
Sbjct: 270 KGDITPLMAASSGGYLDIVKLLLLHDAD-VNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAAENGHAAII 180
A ++ N G TPL AA+ G + + A NE + + + LA GH ++
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFE 232
L + A +T + T + A ++GH + A +L G ++MP FE
Sbjct: 389 RFLLEA-GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
Score = 62.1 bits (144), Expect = 2e-08
Identities = 51/161 (31%), Positives = 79/161 (49%), Gaps = 4/161 (2%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G+ MVR LL A ++ K T TAL A V++AR+L+D GA V+
Sbjct: 376 LTLACYKGHLDMVRFLLEAGADQEHK--TDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ ++PL +AA G L AN ++E TP+ AA GH ++ LL +
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Query: 187 FKASIFERTKD-GSTLMHIASLNGHADCAMMLFKKGVYLHM 226
A+I +T++ T + +A G ++ A L K G + +
Sbjct: 494 -GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL 533
Score = 53.6 bits (123), Expect = 7e-06
Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 2/165 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL+ A AG+ + R LL + ++AL LA + +DM R L++
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNE-FKESALTLACYKGHLDMVRFLLEA 394
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA + T L A +G + + A + + +P+ LAA GH +
Sbjct: 395 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 454
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
LL ++ A++ E +G T + A+ GH + +L +G ++
Sbjct: 455 ALLIER-GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Score = 52.8 bits (121), Expect = 1e-05
Identities = 48/194 (24%), Positives = 87/194 (44%), Gaps = 13/194 (6%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA GHV + L+++G +++ ++ YT L A +V LL GA+++ + +
Sbjct: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
+ET L +A + A L+K+GA TP+ A++ G+L + LL G +
Sbjct: 505 QETALTLAC-CGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGAN 560
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD--EDG 847
T TG+T L AC + D+ L++ D + ++ +D +
Sbjct: 561 VHATT-------ATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDPAKHQ 613
Query: 848 ASALHYACKVTKEE 861
ACK+ ++E
Sbjct: 614 VRVAFDACKLLRKE 627
Score = 52.4 bits (120), Expect = 2e-05
Identities = 42/125 (33%), Positives = 56/125 (44%), Gaps = 4/125 (3%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V G PL+ A G++ MV LL AQ A T +TAL LA ++A L+
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVA-LLLAQGANINAQTEETQETALTLACCGGFSEVADFLI 525
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
GA ++ TPL A+ EG LVKY AN T + A ENGH
Sbjct: 526 KAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTD 582
Query: 179 IIELL 183
+ ++L
Sbjct: 583 VADVL 587
Score = 51.6 bits (118), Expect = 3e-05
Identities = 45/160 (28%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G+ + L+ + L+ G T L AAR +M +L+ GA ++
Sbjct: 441 PLTLAACGGHVELAALLI--ERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Query: 126 A-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A T +T L +A G + + ++A A I + TP+ A++ GH +++ L
Sbjct: 499 AQTEETQETALTLACCGGFSEVADFL--IKAGADI-ELGCSTPLMEASQEGHLELVKYLL 555
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
A++ T G T + A NGH D A +L + G L
Sbjct: 556 AS-GANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/162 (25%), Positives = 68/162 (41%), Gaps = 3/162 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGD-TALHLAARRRDVDMARILVD 119
+ G+ L LA AG + + LL+ + + GD T L A+ +D+ ++L+
Sbjct: 236 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK--GDITPLMAASSGGYLDIVKLLLL 293
Query: 120 YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
+ A V++ + G T L A A G +VK AN + TP+ AA GH +
Sbjct: 294 HDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEV 353
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+L D + + + +A GH D L + G
Sbjct: 354 ARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
Score = 45.6 bits (103), Expect = 0.002
Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 2/121 (1%)
Query: 110 DVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE-DRTPM 168
DV+ R L+D G V+ G++ L +A + G L + + AN N+ D TP+
Sbjct: 217 DVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPL 276
Query: 169 HLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
A+ G+ I++LL A + ++ G+T + A G D +L +G + N
Sbjct: 277 MAASSGGYLDIVKLLL-LHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 229 K 229
+
Sbjct: 336 E 336
Score = 41.5 bits (93), Expect = 0.031
Identities = 38/130 (29%), Positives = 62/130 (47%), Gaps = 8/130 (6%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY-TALHIAVESCKPAVVETLLGYGA 720
+G + AAR GH ++ LL +G +++ T + TAL +A V + L+ GA
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529
Query: 721 DVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
D+ + TPL A++ +G + LL SGA + T G T + A + G+
Sbjct: 530 DIEL----GCSTPLMEASQ--EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 583
Query: 780 LVLLLEDGGD 789
+LL+ G D
Sbjct: 584 ADVLLQAGAD 593
Score = 38.3 bits (85), Expect = 0.29
Identities = 22/60 (36%), Positives = 34/60 (56%), Gaps = 2/60 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL+ A + G+ +V+ LL++ + ATT GDTAL A D+A +L+ GA +D
Sbjct: 538 PLMEASQEGHLELVKYLLAS--GANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
Score = 37.9 bits (84), Expect = 0.39
Identities = 28/111 (25%), Positives = 49/111 (44%), Gaps = 1/111 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
L AE H+ + L A + G V LL +G +N + G + L A AG
Sbjct: 190 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 249
Query: 1358 HLNVVKLLCESGASPKSETNL-NCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
+ + ++L A+ + N + P+ A+S + D+++ LL + D S
Sbjct: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
>BC009420-1|AAH09420.1| 616|Homo sapiens ankyrin repeat and KH domain
containing 1 protein.
Length = 616
Score = 134 bits (324), Expect = 3e-30
Identities = 119/411 (28%), Positives = 184/411 (44%), Gaps = 22/411 (5%)
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
V+ RS L A G + LL +N G + L LA GY L + L+ H
Sbjct: 193 VDTRS-LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 251
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
+ D TPL A++ G +++ KLLL A++++ G + A + ++V+
Sbjct: 252 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 311
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLA 1139
+ L + N + ++G+T AA G V+V L+ G+ + N+ +S L LA
Sbjct: 312 VLLNEGAN-IEDHNENGHTPLMEAASAGHVEVARVLLDHG-AGINTHSNEFKESA-LTLA 368
Query: 1140 AEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGL 1199
GH D+VR L+ AGA + TA+ A GH V ++ +
Sbjct: 369 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 428
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
+PL +AA G E L+ G +L V + G TPL AA G+E +
Sbjct: 429 SPLTLAACGGHVELAALLIER-----------GANLEEV--NDEGYTPLMEAAREGHEEM 475
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
V LLL + G +A + E L LAC GG + L+ A++ + T L
Sbjct: 476 VALLL-AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI----ELGCSTPLME 530
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
AS GH ++V+ LL GA ++AT G T L A + GH +V +L ++GA
Sbjct: 531 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 581
Score = 131 bits (317), Expect = 2e-29
Identities = 120/413 (29%), Positives = 189/413 (45%), Gaps = 25/413 (6%)
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A +G + V+ L+ D ++ T + ++ L LA ++G E+ ++LL + AN++
Sbjct: 201 ACSDGDVNAVRKLL-DEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 259
Query: 1062 GQ-KPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDR 1120
G P+ AA+ Y ++V+L L H V + + GNT A G V +++ L+ +
Sbjct: 260 GDITPLMAASSGGYLDIVKLLLL-HDADVNSQSATGNTALTYACAGGFVDIVKVLL--NE 316
Query: 1121 TGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASC-TDENRAGLTAVHLAAEHGHTN 1179
I N+ N TPL AA GH +V RVL+ GA T N +A+ LA GH +
Sbjct: 317 GANIEDHNE-NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 375
Query: 1180 VLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVL 1239
++ + + T L A G E R LL +G + +
Sbjct: 376 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD-----------SGAQVN--M 422
Query: 1240 GAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLL 1299
A+S +PL LAA G+ + LL+ G + N+ GY PL A GH +V LLL
Sbjct: 423 PADSFESPLTLAACGGHVELAALLIER-GANLEEV-NDEGYTPLMEAAREGHEEMVALLL 480
Query: 1300 SRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
++ A + T+ +T L +A G ++ + L+ GA+I TPL A++ GHL
Sbjct: 481 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHL 537
Query: 1360 NVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDK 1412
+VK L SGA+ + T + +A H DV + LL D D K
Sbjct: 538 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 590
Score = 122 bits (295), Expect = 1e-26
Identities = 115/408 (28%), Positives = 179/408 (43%), Gaps = 27/408 (6%)
Query: 936 ACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNG 995
AC G + V LL V+ EG S L LA GY ++ LL A + + G
Sbjct: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
Query: 996 R-TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
T L A+ GY +VK L+ H+A ++ + T L A A G +++ K+LL GAN
Sbjct: 261 DITPLMAASSGGYLDIVKLLLL-HDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 319
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
I+ +E G P+ AA + EV ++ L + + + + +A +G + ++
Sbjct: 320 IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRF 379
Query: 1115 LMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
L++ G T L A GH +V R+L+ +GA + + + LAA
Sbjct: 380 LLE---AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 436
Query: 1175 HGHTNV--LDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
GH + L + R N ++ + G TPL AA G E V LL+ G
Sbjct: 437 GGHVELAALLIERGANLEEVNDE--GYTPLMEAAREGHEEMVALLLAQ-----------G 483
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHM 1292
+ + E+ T L LA G V L+ AG + + PL A GH+
Sbjct: 484 AN-INAQTEETQETALTLACCGGFSEVADFLI-KAGADIELGCS----TPLMEASQEGHL 537
Query: 1293 SIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN 1340
+V LL+ A +H+T G T L A +GH + +VLL GA+++
Sbjct: 538 ELVKYLLASGAN-VHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
Score = 109 bits (262), Expect = 1e-22
Identities = 120/425 (28%), Positives = 189/425 (44%), Gaps = 38/425 (8%)
Query: 665 RSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHI 724
RS+ A G V + LL +G SV+ T + + L +A + + + LL A+V
Sbjct: 196 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 255
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLL 784
RG K TPL A+ D L+LL A N + G T + A G + + +LL
Sbjct: 256 RGNKGDITPLMAASSGGYLDIVKLLLLHD-ADVNSQSATGNTALTYACAGGFVDIVKVLL 314
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD 844
+G + + G TPL A + ++ R L+ DH G ++T +
Sbjct: 315 NEGANIEDHNE-------NGHTPLMEAASAGHVEVARVLL----DH-GAGINT----HSN 358
Query: 845 EDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNND 904
E SAL AC +V+ L+E GAD +T H TA + G+ +
Sbjct: 359 EFKESALTLACY---------KGHLDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVE 408
Query: 905 VMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRS 964
V ++ D +N +PL +A GH++L L+ A ++ + EG +
Sbjct: 409 VARLLL------DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYT 462
Query: 965 ALHLAAEHGYLQVCDALLTNKAFINSKARNGR-TALHLAAMNGYAHLVKFLIRDHNAMID 1023
L AA G+ ++ LL A IN++ + TAL LA G++ + FLI+ A D
Sbjct: 463 PLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIK---AGAD 519
Query: 1024 VLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
+ L TPL A+ G +E+ K LL GAN+ AT G + A +N +++V + LQ
Sbjct: 520 I-ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 578
Query: 1084 QHPNL 1088
+L
Sbjct: 579 AGADL 583
Score = 107 bits (258), Expect = 3e-22
Identities = 101/382 (26%), Positives = 165/382 (43%), Gaps = 28/382 (7%)
Query: 1132 DSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT-L 1190
D+ L A G + VR L+ G S + G + + LA G+ + V+ + + +
Sbjct: 194 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 253
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG------------VSLVPV 1238
K +TPL A+ G + V+ LL H V S++ TG V +V V
Sbjct: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLH-DADVNSQSATGNTALTYACAGGFVDIVKV 312
Query: 1239 L---GA------ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFG 1289
L GA E+G TPL AA G+ V R+LL+ G + SNE + L LAC+
Sbjct: 313 LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH-GAGINTHSNEFKESALTLACYK 371
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP 1349
GH+ +V LL A+ H TD T L A GH ++ +LL GA++N + +P
Sbjct: 372 GHLDMVRFLLEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 430
Query: 1350 LHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLM 1409
L AA GH+ + LL E GA+ + + P+ AA E H +++ LL + + +
Sbjct: 431 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 490
Query: 1410 DDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKERAKDLIAAG 1469
++ + + C + + +F++ + A ++ + + E K L+A+G
Sbjct: 491 EETQETALTLACCGGFSE--VADFLIKAGADIELGCSTPLMEAS-QEGHLELVKYLLASG 547
Query: 1470 KQCEXXXXXXXXXXXXXDSAGH 1491
GH
Sbjct: 548 ANVHATTATGDTALTYACENGH 569
Score = 101 bits (242), Expect = 3e-20
Identities = 118/425 (27%), Positives = 190/425 (44%), Gaps = 45/425 (10%)
Query: 736 IAARIPDGDKCALM-LLKSGAGPNKATEDGMTPVHVAAKFG--NLATLVLLLEDGGDPLR 792
+A DGD A+ LL G N+ TE+G + + +A G LA ++L + + R
Sbjct: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED-R 256
Query: 793 KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALH 852
K I TPL A DIV+ L+ D +S + G +AL
Sbjct: 257 GNKGDI-------TPLMAASSGGYLDIVKLLLLHDADVNSQSAT----------GNTALT 299
Query: 853 YACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAH 912
YAC ++ VK L+ GA++ + H T A AG+ +V ++ H
Sbjct: 300 YACAGGFVDI---------VKVLLNEGANIEDHNENGH-TPLMEAASAGHVEVARVLLDH 349
Query: 913 ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEH 972
A ++ N + L +AC++GH+ +V LL A + E +AL A
Sbjct: 350 --GAGIN---THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 404
Query: 973 GYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTP 1032
G+++V LL + A +N A + + L LAA G+ L LI + A ++ + + TP
Sbjct: 405 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI-ERGANLEEVNDEGYTP 463
Query: 1033 LHLAAASGQIEVCKLLLELGANIDA-TDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
L AA G E+ LLL GANI+A T+E + + A +SEV ++ ++ +
Sbjct: 464 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG 523
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
+T A+ +G +++++ L+ +G T L A E GH DV VL
Sbjct: 524 C----STPLMEASQEGHLELVKYLL---ASGANVHATTATGDTALTYACENGHTDVADVL 576
Query: 1152 VRAGA 1156
++AGA
Sbjct: 577 LQAGA 581
Score = 64.1 bits (149), Expect = 5e-09
Identities = 46/172 (26%), Positives = 82/172 (47%), Gaps = 3/172 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G + L+A +G + +LL A+ + + + G+TAL A VD+ ++L++ G
Sbjct: 259 KGDITPLMAASSGGYLDIVKLLLLHDAD-VNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAAENGHAAII 180
A ++ N G TPL AA+ G + + A NE + + + LA GH ++
Sbjct: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFE 232
L + A +T + T + A ++GH + A +L G ++MP FE
Sbjct: 378 RFLLEA-GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 428
Score = 62.1 bits (144), Expect = 2e-08
Identities = 51/161 (31%), Positives = 79/161 (49%), Gaps = 4/161 (2%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G+ MVR LL A ++ K T TAL A V++AR+L+D GA V+
Sbjct: 365 LTLACYKGHLDMVRFLLEAGADQEHK--TDEMHTALMEACMDGHVEVARLLLDSGAQVNM 422
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ ++PL +AA G L AN ++E TP+ AA GH ++ LL +
Sbjct: 423 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
Query: 187 FKASIFERTKD-GSTLMHIASLNGHADCAMMLFKKGVYLHM 226
A+I +T++ T + +A G ++ A L K G + +
Sbjct: 483 -GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL 522
Score = 53.6 bits (123), Expect = 7e-06
Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 2/165 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL+ A AG+ + R LL + ++AL LA + +DM R L++
Sbjct: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNE-FKESALTLACYKGHLDMVRFLLEA 383
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA + T L A +G + + A + + +P+ LAA GH +
Sbjct: 384 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 443
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
LL ++ A++ E +G T + A+ GH + +L +G ++
Sbjct: 444 ALLIER-GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 487
Score = 52.8 bits (121), Expect = 1e-05
Identities = 48/194 (24%), Positives = 87/194 (44%), Gaps = 13/194 (6%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA GHV + L+++G +++ ++ YT L A +V LL GA+++ + +
Sbjct: 434 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 493
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
+ET L +A + A L+K+GA TP+ A++ G+L + LL G +
Sbjct: 494 QETALTLAC-CGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGAN 549
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD--EDG 847
T TG+T L AC + D+ L++ D + ++ +D +
Sbjct: 550 VHATT-------ATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDPAKHQ 602
Query: 848 ASALHYACKVTKEE 861
ACK+ ++E
Sbjct: 603 VRVAFDACKLLRKE 616
Score = 52.4 bits (120), Expect = 2e-05
Identities = 42/125 (33%), Positives = 56/125 (44%), Gaps = 4/125 (3%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V G PL+ A G++ MV LL AQ A T +TAL LA ++A L+
Sbjct: 456 VNDEGYTPLMEAAREGHEEMVA-LLLAQGANINAQTEETQETALTLACCGGFSEVADFLI 514
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
GA ++ TPL A+ EG LVKY AN T + A ENGH
Sbjct: 515 KAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTD 571
Query: 179 IIELL 183
+ ++L
Sbjct: 572 VADVL 576
Score = 51.6 bits (118), Expect = 3e-05
Identities = 45/160 (28%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G+ + L+ + L+ G T L AAR +M +L+ GA ++
Sbjct: 430 PLTLAACGGHVELAALLI--ERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 487
Query: 126 A-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A T +T L +A G + + ++A A I + TP+ A++ GH +++ L
Sbjct: 488 AQTEETQETALTLACCGGFSEVADFL--IKAGADI-ELGCSTPLMEASQEGHLELVKYLL 544
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
A++ T G T + A NGH D A +L + G L
Sbjct: 545 AS-GANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/162 (25%), Positives = 68/162 (41%), Gaps = 3/162 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGD-TALHLAARRRDVDMARILVD 119
+ G+ L LA AG + + LL+ + + GD T L A+ +D+ ++L+
Sbjct: 225 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK--GDITPLMAASSGGYLDIVKLLLL 282
Query: 120 YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
+ A V++ + G T L A A G +VK AN + TP+ AA GH +
Sbjct: 283 HDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEV 342
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+L D + + + +A GH D L + G
Sbjct: 343 ARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 384
Score = 45.6 bits (103), Expect = 0.002
Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 2/121 (1%)
Query: 110 DVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE-DRTPM 168
DV+ R L+D G V+ G++ L +A + G L + + AN N+ D TP+
Sbjct: 206 DVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPL 265
Query: 169 HLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
A+ G+ I++LL A + ++ G+T + A G D +L +G + N
Sbjct: 266 MAASSGGYLDIVKLLL-LHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
Query: 229 K 229
+
Sbjct: 325 E 325
Score = 41.5 bits (93), Expect = 0.031
Identities = 38/130 (29%), Positives = 62/130 (47%), Gaps = 8/130 (6%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY-TALHIAVESCKPAVVETLLGYGA 720
+G + AAR GH ++ LL +G +++ T + TAL +A V + L+ GA
Sbjct: 459 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 518
Query: 721 DVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
D+ + TPL A++ +G + LL SGA + T G T + A + G+
Sbjct: 519 DIEL----GCSTPLMEASQ--EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 572
Query: 780 LVLLLEDGGD 789
+LL+ G D
Sbjct: 573 ADVLLQAGAD 582
Score = 38.3 bits (85), Expect = 0.29
Identities = 22/60 (36%), Positives = 34/60 (56%), Gaps = 2/60 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL+ A + G+ +V+ LL++ + ATT GDTAL A D+A +L+ GA +D
Sbjct: 527 PLMEASQEGHLELVKYLLAS--GANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
Score = 37.9 bits (84), Expect = 0.39
Identities = 28/111 (25%), Positives = 49/111 (44%), Gaps = 1/111 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
L AE H+ + L A + G V LL +G +N + G + L A AG
Sbjct: 179 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 238
Query: 1358 HLNVVKLLCESGASPKSETNL-NCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
+ + ++L A+ + N + P+ A+S + D+++ LL + D S
Sbjct: 239 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 289
>BC004457-1|AAH04457.2| 627|Homo sapiens ankyrin repeat and KH domain
containing 1 protein.
Length = 627
Score = 134 bits (324), Expect = 3e-30
Identities = 119/411 (28%), Positives = 184/411 (44%), Gaps = 22/411 (5%)
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
V+ RS L A G + LL +N G + L LA GY L + L+ H
Sbjct: 204 VDTRS-LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 262
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
+ D TPL A++ G +++ KLLL A++++ G + A + ++V+
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLA 1139
+ L + N + ++G+T AA G V+V L+ G+ + N+ +S L LA
Sbjct: 323 VLLNEGAN-IEDHNENGHTPLMEAASAGHVEVARVLLDHG-AGINTHSNEFKESA-LTLA 379
Query: 1140 AEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGL 1199
GH D+VR L+ AGA + TA+ A GH V ++ +
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
+PL +AA G E L+ G +L V + G TPL AA G+E +
Sbjct: 440 SPLTLAACGGHVELAALLIER-----------GANLEEV--NDEGYTPLMEAAREGHEEM 486
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
V LLL + G +A + E L LAC GG + L+ A++ + T L
Sbjct: 487 VALLL-AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI----ELGCSTPLME 541
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
AS GH ++V+ LL GA ++AT G T L A + GH +V +L ++GA
Sbjct: 542 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 592
Score = 131 bits (317), Expect = 2e-29
Identities = 120/413 (29%), Positives = 189/413 (45%), Gaps = 25/413 (6%)
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A +G + V+ L+ D ++ T + ++ L LA ++G E+ ++LL + AN++
Sbjct: 212 ACSDGDVNAVRKLL-DEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 270
Query: 1062 GQ-KPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDR 1120
G P+ AA+ Y ++V+L L H V + + GNT A G V +++ L+ +
Sbjct: 271 GDITPLMAASSGGYLDIVKLLLL-HDADVNSQSATGNTALTYACAGGFVDIVKVLL--NE 327
Query: 1121 TGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASC-TDENRAGLTAVHLAAEHGHTN 1179
I N+ N TPL AA GH +V RVL+ GA T N +A+ LA GH +
Sbjct: 328 GANIEDHNE-NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386
Query: 1180 VLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVL 1239
++ + + T L A G E R LL +G + +
Sbjct: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD-----------SGAQVN--M 433
Query: 1240 GAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLL 1299
A+S +PL LAA G+ + LL+ G + N+ GY PL A GH +V LLL
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIER-GANLEEV-NDEGYTPLMEAAREGHEEMVALLL 491
Query: 1300 SRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
++ A + T+ +T L +A G ++ + L+ GA+I TPL A++ GHL
Sbjct: 492 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHL 548
Query: 1360 NVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDK 1412
+VK L SGA+ + T + +A H DV + LL D D K
Sbjct: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 601
Score = 122 bits (295), Expect = 1e-26
Identities = 115/408 (28%), Positives = 179/408 (43%), Gaps = 27/408 (6%)
Query: 936 ACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNG 995
AC G + V LL V+ EG S L LA GY ++ LL A + + G
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 996 R-TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
T L A+ GY +VK L+ H+A ++ + T L A A G +++ K+LL GAN
Sbjct: 272 DITPLMAASSGGYLDIVKLLLL-HDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 330
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
I+ +E G P+ AA + EV ++ L + + + + +A +G + ++
Sbjct: 331 IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRF 390
Query: 1115 LMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
L++ G T L A GH +V R+L+ +GA + + + LAA
Sbjct: 391 LLE---AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447
Query: 1175 HGHTNV--LDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
GH + L + R N ++ + G TPL AA G E V LL+ G
Sbjct: 448 GGHVELAALLIERGANLEEVNDE--GYTPLMEAAREGHEEMVALLLAQ-----------G 494
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHM 1292
+ + E+ T L LA G V L+ AG + + PL A GH+
Sbjct: 495 AN-INAQTEETQETALTLACCGGFSEVADFLI-KAGADIELGCS----TPLMEASQEGHL 548
Query: 1293 SIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN 1340
+V LL+ A +H+T G T L A +GH + +VLL GA+++
Sbjct: 549 ELVKYLLASGAN-VHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
Score = 109 bits (262), Expect = 1e-22
Identities = 120/425 (28%), Positives = 189/425 (44%), Gaps = 38/425 (8%)
Query: 665 RSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHI 724
RS+ A G V + LL +G SV+ T + + L +A + + + LL A+V
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 266
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLL 784
RG K TPL A+ D L+LL A N + G T + A G + + +LL
Sbjct: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHD-ADVNSQSATGNTALTYACAGGFVDIVKVLL 325
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD 844
+G + + G TPL A + ++ R L+ DH G ++T +
Sbjct: 326 NEGANIEDHNE-------NGHTPLMEAASAGHVEVARVLL----DH-GAGINT----HSN 369
Query: 845 EDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNND 904
E SAL AC +V+ L+E GAD +T H TA + G+ +
Sbjct: 370 EFKESALTLACY---------KGHLDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVE 419
Query: 905 VMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRS 964
V ++ D +N +PL +A GH++L L+ A ++ + EG +
Sbjct: 420 VARLLL------DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYT 473
Query: 965 ALHLAAEHGYLQVCDALLTNKAFINSKARNGR-TALHLAAMNGYAHLVKFLIRDHNAMID 1023
L AA G+ ++ LL A IN++ + TAL LA G++ + FLI+ A D
Sbjct: 474 PLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIK---AGAD 530
Query: 1024 VLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
+ L TPL A+ G +E+ K LL GAN+ AT G + A +N +++V + LQ
Sbjct: 531 I-ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589
Query: 1084 QHPNL 1088
+L
Sbjct: 590 AGADL 594
Score = 107 bits (258), Expect = 3e-22
Identities = 101/382 (26%), Positives = 165/382 (43%), Gaps = 28/382 (7%)
Query: 1132 DSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT-L 1190
D+ L A G + VR L+ G S + G + + LA G+ + V+ + + +
Sbjct: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG------------VSLVPV 1238
K +TPL A+ G + V+ LL H V S++ TG V +V V
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLH-DADVNSQSATGNTALTYACAGGFVDIVKV 323
Query: 1239 L---GA------ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFG 1289
L GA E+G TPL AA G+ V R+LL+ G + SNE + L LAC+
Sbjct: 324 LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH-GAGINTHSNEFKESALTLACYK 382
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP 1349
GH+ +V LL A+ H TD T L A GH ++ +LL GA++N + +P
Sbjct: 383 GHLDMVRFLLEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 441
Query: 1350 LHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLM 1409
L AA GH+ + LL E GA+ + + P+ AA E H +++ LL + + +
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
Query: 1410 DDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKERAKDLIAAG 1469
++ + + C + + +F++ + A ++ + + E K L+A+G
Sbjct: 502 EETQETALTLACCGGFSE--VADFLIKAGADIELGCSTPLMEAS-QEGHLELVKYLLASG 558
Query: 1470 KQCEXXXXXXXXXXXXXDSAGH 1491
GH
Sbjct: 559 ANVHATTATGDTALTYACENGH 580
Score = 101 bits (242), Expect = 3e-20
Identities = 118/425 (27%), Positives = 190/425 (44%), Gaps = 45/425 (10%)
Query: 736 IAARIPDGDKCALM-LLKSGAGPNKATEDGMTPVHVAAKFG--NLATLVLLLEDGGDPLR 792
+A DGD A+ LL G N+ TE+G + + +A G LA ++L + + R
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED-R 267
Query: 793 KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALH 852
K I TPL A DIV+ L+ D +S + G +AL
Sbjct: 268 GNKGDI-------TPLMAASSGGYLDIVKLLLLHDADVNSQSAT----------GNTALT 310
Query: 853 YACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAH 912
YAC ++ VK L+ GA++ + H T A AG+ +V ++ H
Sbjct: 311 YACAGGFVDI---------VKVLLNEGANIEDHNENGH-TPLMEAASAGHVEVARVLLDH 360
Query: 913 ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEH 972
A ++ N + L +AC++GH+ +V LL A + E +AL A
Sbjct: 361 --GAGIN---THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 415
Query: 973 GYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTP 1032
G+++V LL + A +N A + + L LAA G+ L LI + A ++ + + TP
Sbjct: 416 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI-ERGANLEEVNDEGYTP 474
Query: 1033 LHLAAASGQIEVCKLLLELGANIDA-TDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
L AA G E+ LLL GANI+A T+E + + A +SEV ++ ++ +
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG 534
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
+T A+ +G +++++ L+ +G T L A E GH DV VL
Sbjct: 535 C----STPLMEASQEGHLELVKYLL---ASGANVHATTATGDTALTYACENGHTDVADVL 587
Query: 1152 VRAGA 1156
++AGA
Sbjct: 588 LQAGA 592
Score = 64.1 bits (149), Expect = 5e-09
Identities = 46/172 (26%), Positives = 82/172 (47%), Gaps = 3/172 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G + L+A +G + +LL A+ + + + G+TAL A VD+ ++L++ G
Sbjct: 270 KGDITPLMAASSGGYLDIVKLLLLHDAD-VNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAAENGHAAII 180
A ++ N G TPL AA+ G + + A NE + + + LA GH ++
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFE 232
L + A +T + T + A ++GH + A +L G ++MP FE
Sbjct: 389 RFLLEA-GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
Score = 62.1 bits (144), Expect = 2e-08
Identities = 51/161 (31%), Positives = 79/161 (49%), Gaps = 4/161 (2%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G+ MVR LL A ++ K T TAL A V++AR+L+D GA V+
Sbjct: 376 LTLACYKGHLDMVRFLLEAGADQEHK--TDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ ++PL +AA G L AN ++E TP+ AA GH ++ LL +
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Query: 187 FKASIFERTKD-GSTLMHIASLNGHADCAMMLFKKGVYLHM 226
A+I +T++ T + +A G ++ A L K G + +
Sbjct: 494 -GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL 533
Score = 53.6 bits (123), Expect = 7e-06
Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 2/165 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL+ A AG+ + R LL + ++AL LA + +DM R L++
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNE-FKESALTLACYKGHLDMVRFLLEA 394
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA + T L A +G + + A + + +P+ LAA GH +
Sbjct: 395 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 454
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
LL ++ A++ E +G T + A+ GH + +L +G ++
Sbjct: 455 ALLIER-GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Score = 52.8 bits (121), Expect = 1e-05
Identities = 48/194 (24%), Positives = 87/194 (44%), Gaps = 13/194 (6%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA GHV + L+++G +++ ++ YT L A +V LL GA+++ + +
Sbjct: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
+ET L +A + A L+K+GA TP+ A++ G+L + LL G +
Sbjct: 505 QETALTLAC-CGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGAN 560
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD--EDG 847
T TG+T L AC + D+ L++ D + ++ +D +
Sbjct: 561 VHATT-------ATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDPAKHQ 613
Query: 848 ASALHYACKVTKEE 861
ACK+ ++E
Sbjct: 614 VRVAFDACKLLRKE 627
Score = 52.4 bits (120), Expect = 2e-05
Identities = 42/125 (33%), Positives = 56/125 (44%), Gaps = 4/125 (3%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V G PL+ A G++ MV LL AQ A T +TAL LA ++A L+
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVA-LLLAQGANINAQTEETQETALTLACCGGFSEVADFLI 525
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
GA ++ TPL A+ EG LVKY AN T + A ENGH
Sbjct: 526 KAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTD 582
Query: 179 IIELL 183
+ ++L
Sbjct: 583 VADVL 587
Score = 51.6 bits (118), Expect = 3e-05
Identities = 45/160 (28%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G+ + L+ + L+ G T L AAR +M +L+ GA ++
Sbjct: 441 PLTLAACGGHVELAALLI--ERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Query: 126 A-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A T +T L +A G + + ++A A I + TP+ A++ GH +++ L
Sbjct: 499 AQTEETQETALTLACCGGFSEVADFL--IKAGADI-ELGCSTPLMEASQEGHLELVKYLL 555
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
A++ T G T + A NGH D A +L + G L
Sbjct: 556 AS-GANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/162 (25%), Positives = 68/162 (41%), Gaps = 3/162 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGD-TALHLAARRRDVDMARILVD 119
+ G+ L LA AG + + LL+ + + GD T L A+ +D+ ++L+
Sbjct: 236 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK--GDITPLMAASSGGYLDIVKLLLL 293
Query: 120 YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
+ A V++ + G T L A A G +VK AN + TP+ AA GH +
Sbjct: 294 HDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEV 353
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+L D + + + +A GH D L + G
Sbjct: 354 ARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
Score = 45.6 bits (103), Expect = 0.002
Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 2/121 (1%)
Query: 110 DVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE-DRTPM 168
DV+ R L+D G V+ G++ L +A + G L + + AN N+ D TP+
Sbjct: 217 DVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPL 276
Query: 169 HLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
A+ G+ I++LL A + ++ G+T + A G D +L +G + N
Sbjct: 277 MAASSGGYLDIVKLLL-LHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 229 K 229
+
Sbjct: 336 E 336
Score = 41.5 bits (93), Expect = 0.031
Identities = 38/130 (29%), Positives = 62/130 (47%), Gaps = 8/130 (6%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY-TALHIAVESCKPAVVETLLGYGA 720
+G + AAR GH ++ LL +G +++ T + TAL +A V + L+ GA
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529
Query: 721 DVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
D+ + TPL A++ +G + LL SGA + T G T + A + G+
Sbjct: 530 DIEL----GCSTPLMEASQ--EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 583
Query: 780 LVLLLEDGGD 789
+LL+ G D
Sbjct: 584 ADVLLQAGAD 593
Score = 38.3 bits (85), Expect = 0.29
Identities = 22/60 (36%), Positives = 34/60 (56%), Gaps = 2/60 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL+ A + G+ +V+ LL++ + ATT GDTAL A D+A +L+ GA +D
Sbjct: 538 PLMEASQEGHLELVKYLLAS--GANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
Score = 37.9 bits (84), Expect = 0.39
Identities = 28/111 (25%), Positives = 49/111 (44%), Gaps = 1/111 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
L AE H+ + L A + G V LL +G +N + G + L A AG
Sbjct: 190 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 249
Query: 1358 HLNVVKLLCESGASPKSETNL-NCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
+ + ++L A+ + N + P+ A+S + D+++ LL + D S
Sbjct: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
>AK022041-1|BAB13958.1| 435|Homo sapiens protein ( Homo sapiens cDNA
FLJ11979 fis, clone HEMBB1001282, weakly similar to
ANKYRIN R. ).
Length = 435
Score = 134 bits (324), Expect = 3e-30
Identities = 119/411 (28%), Positives = 184/411 (44%), Gaps = 22/411 (5%)
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
V+ RS L A G + LL +N G + L LA GY L + L+ H
Sbjct: 12 VDTRS-LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 70
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
+ D TPL A++ G +++ KLLL A++++ G + A + ++V+
Sbjct: 71 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 130
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLA 1139
+ L + N + ++G+T AA G V+V L+ G+ + N+ +S L LA
Sbjct: 131 VLLNEGAN-IEDHNENGHTPLMEAASAGHVEVARVLLDHG-AGINTHSNEFKESA-LTLA 187
Query: 1140 AEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGL 1199
GH D+VR L+ AGA + TA+ A GH V ++ +
Sbjct: 188 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 247
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
+PL +AA G E L+ G +L V + G TPL AA G+E +
Sbjct: 248 SPLTLAACGGHVELAALLIER-----------GANLEEV--NDEGYTPLMEAAREGHEEM 294
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
V LLL + G +A + E L LAC GG + L+ A++ + T L
Sbjct: 295 VALLL-AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI----ELGCSTPLME 349
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
AS GH ++V+ LL GA ++AT G T L A + GH +V +L ++GA
Sbjct: 350 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 400
Score = 131 bits (317), Expect = 2e-29
Identities = 120/413 (29%), Positives = 189/413 (45%), Gaps = 25/413 (6%)
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A +G + V+ L+ D ++ T + ++ L LA ++G E+ ++LL + AN++
Sbjct: 20 ACSDGDVNAVRKLL-DEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 78
Query: 1062 GQ-KPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDR 1120
G P+ AA+ Y ++V+L L H V + + GNT A G V +++ L+ +
Sbjct: 79 GDITPLMAASSGGYLDIVKLLLL-HDADVNSQSATGNTALTYACAGGFVDIVKVLL--NE 135
Query: 1121 TGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASC-TDENRAGLTAVHLAAEHGHTN 1179
I N+ N TPL AA GH +V RVL+ GA T N +A+ LA GH +
Sbjct: 136 GANIEDHNE-NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 194
Query: 1180 VLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVL 1239
++ + + T L A G E R LL +G + +
Sbjct: 195 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD-----------SGAQVN--M 241
Query: 1240 GAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLL 1299
A+S +PL LAA G+ + LL+ G + N+ GY PL A GH +V LLL
Sbjct: 242 PADSFESPLTLAACGGHVELAALLIER-GANLEEV-NDEGYTPLMEAAREGHEEMVALLL 299
Query: 1300 SRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
++ A + T+ +T L +A G ++ + L+ GA+I TPL A++ GHL
Sbjct: 300 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHL 356
Query: 1360 NVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDK 1412
+VK L SGA+ + T + +A H DV + LL D D K
Sbjct: 357 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 409
Score = 122 bits (295), Expect = 1e-26
Identities = 115/408 (28%), Positives = 179/408 (43%), Gaps = 27/408 (6%)
Query: 936 ACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNG 995
AC G + V LL V+ EG S L LA GY ++ LL A + + G
Sbjct: 20 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 79
Query: 996 R-TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
T L A+ GY +VK L+ H+A ++ + T L A A G +++ K+LL GAN
Sbjct: 80 DITPLMAASSGGYLDIVKLLLL-HDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 138
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
I+ +E G P+ AA + EV ++ L + + + + +A +G + ++
Sbjct: 139 IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRF 198
Query: 1115 LMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
L++ G T L A GH +V R+L+ +GA + + + LAA
Sbjct: 199 LLE---AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 255
Query: 1175 HGHTNV--LDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
GH + L + R N ++ + G TPL AA G E V LL+ G
Sbjct: 256 GGHVELAALLIERGANLEEVNDE--GYTPLMEAAREGHEEMVALLLAQ-----------G 302
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHM 1292
+ + E+ T L LA G V L+ AG + + PL A GH+
Sbjct: 303 AN-INAQTEETQETALTLACCGGFSEVADFLI-KAGADIELGCS----TPLMEASQEGHL 356
Query: 1293 SIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN 1340
+V LL+ A +H+T G T L A +GH + +VLL GA+++
Sbjct: 357 ELVKYLLASGAN-VHATTATGDTALTYACENGHTDVADVLLQAGADLD 403
Score = 109 bits (262), Expect = 1e-22
Identities = 120/425 (28%), Positives = 189/425 (44%), Gaps = 38/425 (8%)
Query: 665 RSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHI 724
RS+ A G V + LL +G SV+ T + + L +A + + + LL A+V
Sbjct: 15 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 74
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLL 784
RG K TPL A+ D L+LL A N + G T + A G + + +LL
Sbjct: 75 RGNKGDITPLMAASSGGYLDIVKLLLLHD-ADVNSQSATGNTALTYACAGGFVDIVKVLL 133
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD 844
+G + + G TPL A + ++ R L+ DH G ++T +
Sbjct: 134 NEGANIEDHNE-------NGHTPLMEAASAGHVEVARVLL----DH-GAGINT----HSN 177
Query: 845 EDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNND 904
E SAL AC +V+ L+E GAD +T H TA + G+ +
Sbjct: 178 EFKESALTLACY---------KGHLDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVE 227
Query: 905 VMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRS 964
V ++ D +N +PL +A GH++L L+ A ++ + EG +
Sbjct: 228 VARLLL------DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYT 281
Query: 965 ALHLAAEHGYLQVCDALLTNKAFINSKARNGR-TALHLAAMNGYAHLVKFLIRDHNAMID 1023
L AA G+ ++ LL A IN++ + TAL LA G++ + FLI+ A D
Sbjct: 282 PLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIK---AGAD 338
Query: 1024 VLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
+ L TPL A+ G +E+ K LL GAN+ AT G + A +N +++V + LQ
Sbjct: 339 I-ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 397
Query: 1084 QHPNL 1088
+L
Sbjct: 398 AGADL 402
Score = 107 bits (258), Expect = 3e-22
Identities = 101/382 (26%), Positives = 165/382 (43%), Gaps = 28/382 (7%)
Query: 1132 DSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT-L 1190
D+ L A G + VR L+ G S + G + + LA G+ + V+ + + +
Sbjct: 13 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 72
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG------------VSLVPV 1238
K +TPL A+ G + V+ LL H V S++ TG V +V V
Sbjct: 73 EDRGNKGDITPLMAASSGGYLDIVKLLLLH-DADVNSQSATGNTALTYACAGGFVDIVKV 131
Query: 1239 L---GA------ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFG 1289
L GA E+G TPL AA G+ V R+LL+ G + SNE + L LAC+
Sbjct: 132 LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH-GAGINTHSNEFKESALTLACYK 190
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP 1349
GH+ +V LL A+ H TD T L A GH ++ +LL GA++N + +P
Sbjct: 191 GHLDMVRFLLEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 249
Query: 1350 LHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLM 1409
L AA GH+ + LL E GA+ + + P+ AA E H +++ LL + + +
Sbjct: 250 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 309
Query: 1410 DDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKERAKDLIAAG 1469
++ + + C + + +F++ + A ++ + + E K L+A+G
Sbjct: 310 EETQETALTLACCGGFSE--VADFLIKAGADIELGCSTPLMEAS-QEGHLELVKYLLASG 366
Query: 1470 KQCEXXXXXXXXXXXXXDSAGH 1491
GH
Sbjct: 367 ANVHATTATGDTALTYACENGH 388
Score = 101 bits (242), Expect = 3e-20
Identities = 118/425 (27%), Positives = 190/425 (44%), Gaps = 45/425 (10%)
Query: 736 IAARIPDGDKCALM-LLKSGAGPNKATEDGMTPVHVAAKFG--NLATLVLLLEDGGDPLR 792
+A DGD A+ LL G N+ TE+G + + +A G LA ++L + + R
Sbjct: 17 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED-R 75
Query: 793 KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALH 852
K I TPL A DIV+ L+ D +S + G +AL
Sbjct: 76 GNKGDI-------TPLMAASSGGYLDIVKLLLLHDADVNSQSAT----------GNTALT 118
Query: 853 YACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAH 912
YAC ++ VK L+ GA++ + H T A AG+ +V ++ H
Sbjct: 119 YACAGGFVDI---------VKVLLNEGANIEDHNENGH-TPLMEAASAGHVEVARVLLDH 168
Query: 913 ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEH 972
A ++ N + L +AC++GH+ +V LL A + E +AL A
Sbjct: 169 --GAGIN---THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 223
Query: 973 GYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTP 1032
G+++V LL + A +N A + + L LAA G+ L LI + A ++ + + TP
Sbjct: 224 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI-ERGANLEEVNDEGYTP 282
Query: 1033 LHLAAASGQIEVCKLLLELGANIDA-TDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
L AA G E+ LLL GANI+A T+E + + A +SEV ++ ++ +
Sbjct: 283 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG 342
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
+T A+ +G +++++ L+ +G T L A E GH DV VL
Sbjct: 343 C----STPLMEASQEGHLELVKYLL---ASGANVHATTATGDTALTYACENGHTDVADVL 395
Query: 1152 VRAGA 1156
++AGA
Sbjct: 396 LQAGA 400
Score = 64.1 bits (149), Expect = 5e-09
Identities = 46/172 (26%), Positives = 82/172 (47%), Gaps = 3/172 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G + L+A +G + +LL A+ + + + G+TAL A VD+ ++L++ G
Sbjct: 78 KGDITPLMAASSGGYLDIVKLLLLHDAD-VNSQSATGNTALTYACAGGFVDIVKVLLNEG 136
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAAENGHAAII 180
A ++ N G TPL AA+ G + + A NE + + + LA GH ++
Sbjct: 137 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 196
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFE 232
L + A +T + T + A ++GH + A +L G ++MP FE
Sbjct: 197 RFLLEA-GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 247
Score = 62.1 bits (144), Expect = 2e-08
Identities = 51/161 (31%), Positives = 79/161 (49%), Gaps = 4/161 (2%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G+ MVR LL A ++ K T TAL A V++AR+L+D GA V+
Sbjct: 184 LTLACYKGHLDMVRFLLEAGADQEHK--TDEMHTALMEACMDGHVEVARLLLDSGAQVNM 241
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ ++PL +AA G L AN ++E TP+ AA GH ++ LL +
Sbjct: 242 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 301
Query: 187 FKASIFERTKD-GSTLMHIASLNGHADCAMMLFKKGVYLHM 226
A+I +T++ T + +A G ++ A L K G + +
Sbjct: 302 -GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL 341
Score = 53.6 bits (123), Expect = 7e-06
Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 2/165 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL+ A AG+ + R LL + ++AL LA + +DM R L++
Sbjct: 144 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNE-FKESALTLACYKGHLDMVRFLLEA 202
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA + T L A +G + + A + + +P+ LAA GH +
Sbjct: 203 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 262
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
LL ++ A++ E +G T + A+ GH + +L +G ++
Sbjct: 263 ALLIER-GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 306
Score = 52.8 bits (121), Expect = 1e-05
Identities = 48/194 (24%), Positives = 87/194 (44%), Gaps = 13/194 (6%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA GHV + L+++G +++ ++ YT L A +V LL GA+++ + +
Sbjct: 253 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 312
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
+ET L +A + A L+K+GA TP+ A++ G+L + LL G +
Sbjct: 313 QETALTLAC-CGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGAN 368
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD--EDG 847
T TG+T L AC + D+ L++ D + ++ +D +
Sbjct: 369 VHATT-------ATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDPAKHQ 421
Query: 848 ASALHYACKVTKEE 861
ACK+ ++E
Sbjct: 422 VRVAFDACKLLRKE 435
Score = 52.4 bits (120), Expect = 2e-05
Identities = 42/125 (33%), Positives = 56/125 (44%), Gaps = 4/125 (3%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V G PL+ A G++ MV LL AQ A T +TAL LA ++A L+
Sbjct: 275 VNDEGYTPLMEAAREGHEEMVA-LLLAQGANINAQTEETQETALTLACCGGFSEVADFLI 333
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
GA ++ TPL A+ EG LVKY AN T + A ENGH
Sbjct: 334 KAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTD 390
Query: 179 IIELL 183
+ ++L
Sbjct: 391 VADVL 395
Score = 51.6 bits (118), Expect = 3e-05
Identities = 45/160 (28%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G+ + L+ + L+ G T L AAR +M +L+ GA ++
Sbjct: 249 PLTLAACGGHVELAALLI--ERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 306
Query: 126 A-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A T +T L +A G + + ++A A I + TP+ A++ GH +++ L
Sbjct: 307 AQTEETQETALTLACCGGFSEVADFL--IKAGADI-ELGCSTPLMEASQEGHLELVKYLL 363
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
A++ T G T + A NGH D A +L + G L
Sbjct: 364 AS-GANVHATTATGDTALTYACENGHTDVADVLLQAGADL 402
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/162 (25%), Positives = 68/162 (41%), Gaps = 3/162 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGD-TALHLAARRRDVDMARILVD 119
+ G+ L LA AG + + LL+ + + GD T L A+ +D+ ++L+
Sbjct: 44 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK--GDITPLMAASSGGYLDIVKLLLL 101
Query: 120 YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
+ A V++ + G T L A A G +VK AN + TP+ AA GH +
Sbjct: 102 HDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEV 161
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+L D + + + +A GH D L + G
Sbjct: 162 ARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 203
Score = 45.6 bits (103), Expect = 0.002
Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 2/121 (1%)
Query: 110 DVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE-DRTPM 168
DV+ R L+D G V+ G++ L +A + G L + + AN N+ D TP+
Sbjct: 25 DVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPL 84
Query: 169 HLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
A+ G+ I++LL A + ++ G+T + A G D +L +G + N
Sbjct: 85 MAASSGGYLDIVKLLL-LHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 143
Query: 229 K 229
+
Sbjct: 144 E 144
Score = 41.5 bits (93), Expect = 0.031
Identities = 38/130 (29%), Positives = 62/130 (47%), Gaps = 8/130 (6%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY-TALHIAVESCKPAVVETLLGYGA 720
+G + AAR GH ++ LL +G +++ T + TAL +A V + L+ GA
Sbjct: 278 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 337
Query: 721 DVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
D+ + TPL A++ +G + LL SGA + T G T + A + G+
Sbjct: 338 DIEL----GCSTPLMEASQ--EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 391
Query: 780 LVLLLEDGGD 789
+LL+ G D
Sbjct: 392 ADVLLQAGAD 401
Score = 38.3 bits (85), Expect = 0.29
Identities = 22/60 (36%), Positives = 34/60 (56%), Gaps = 2/60 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL+ A + G+ +V+ LL++ + ATT GDTAL A D+A +L+ GA +D
Sbjct: 346 PLMEASQEGHLELVKYLLAS--GANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 403
Score = 37.5 bits (83), Expect = 0.51
Identities = 27/106 (25%), Positives = 48/106 (45%), Gaps = 1/106 (0%)
Query: 1303 AELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVV 1362
AE H+ + L A + G V LL +G +N + G + L A AG+ +
Sbjct: 3 AENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELA 62
Query: 1363 KLLCESGASPKSETNL-NCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
++L A+ + N + P+ A+S + D+++ LL + D S
Sbjct: 63 QVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 108
>AF258557-1|AAG23760.1| 627|Homo sapiens PP2500 protein.
Length = 627
Score = 134 bits (324), Expect = 3e-30
Identities = 119/411 (28%), Positives = 184/411 (44%), Gaps = 22/411 (5%)
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
V+ RS L A G + LL +N G + L LA GY L + L+ H
Sbjct: 204 VDTRS-LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 262
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
+ D TPL A++ G +++ KLLL A++++ G + A + ++V+
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLA 1139
+ L + N + ++G+T AA G V+V L+ G+ + N+ +S L LA
Sbjct: 323 VLLNEGAN-IEDHNENGHTPLMEAASAGHVEVARVLLDHG-AGINTHSNEFKESA-LTLA 379
Query: 1140 AEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGL 1199
GH D+VR L+ AGA + TA+ A GH V ++ +
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
+PL +AA G E L+ G +L V + G TPL AA G+E +
Sbjct: 440 SPLTLAACGGHVELAALLIER-----------GANLEEV--NDEGYTPLMEAAREGHEEM 486
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
V LLL + G +A + E L LAC GG + L+ A++ + T L
Sbjct: 487 VALLL-AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI----ELGCSTPLME 541
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
AS GH ++V+ LL GA ++AT G T L A + GH +V +L ++GA
Sbjct: 542 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 592
Score = 131 bits (317), Expect = 2e-29
Identities = 120/413 (29%), Positives = 189/413 (45%), Gaps = 25/413 (6%)
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A +G + V+ L+ D ++ T + ++ L LA ++G E+ ++LL + AN++
Sbjct: 212 ACSDGDVNAVRKLL-DEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 270
Query: 1062 GQ-KPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDR 1120
G P+ AA+ Y ++V+L L H V + + GNT A G V +++ L+ +
Sbjct: 271 GDITPLMAASSGGYLDIVKLLLL-HDADVNSQSATGNTALTYACAGGFVDIVKVLL--NE 327
Query: 1121 TGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASC-TDENRAGLTAVHLAAEHGHTN 1179
I N+ N TPL AA GH +V RVL+ GA T N +A+ LA GH +
Sbjct: 328 GANIEDHNE-NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386
Query: 1180 VLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVL 1239
++ + + T L A G E R LL +G + +
Sbjct: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD-----------SGAQVN--M 433
Query: 1240 GAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLL 1299
A+S +PL LAA G+ + LL+ G + N+ GY PL A GH +V LLL
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIER-GANLEEV-NDEGYTPLMEAAREGHEEMVALLL 491
Query: 1300 SRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
++ A + T+ +T L +A G ++ + L+ GA+I TPL A++ GHL
Sbjct: 492 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHL 548
Query: 1360 NVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDK 1412
+VK L SGA+ + T + +A H DV + LL D D K
Sbjct: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 601
Score = 122 bits (295), Expect = 1e-26
Identities = 115/408 (28%), Positives = 179/408 (43%), Gaps = 27/408 (6%)
Query: 936 ACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNG 995
AC G + V LL V+ EG S L LA GY ++ LL A + + G
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 996 R-TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
T L A+ GY +VK L+ H+A ++ + T L A A G +++ K+LL GAN
Sbjct: 272 DITPLMAASSGGYLDIVKLLLL-HDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 330
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
I+ +E G P+ AA + EV ++ L + + + + +A +G + ++
Sbjct: 331 IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRF 390
Query: 1115 LMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
L++ G T L A GH +V R+L+ +GA + + + LAA
Sbjct: 391 LLE---AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447
Query: 1175 HGHTNV--LDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
GH + L + R N ++ + G TPL AA G E V LL+ G
Sbjct: 448 GGHVELAALLIERGANLEEVNDE--GYTPLMEAAREGHEEMVALLLAQ-----------G 494
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHM 1292
+ + E+ T L LA G V L+ AG + + PL A GH+
Sbjct: 495 AN-INAQTEETQETALTLACCGGFSEVADFLI-KAGADIELGCS----TPLMEASQEGHL 548
Query: 1293 SIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN 1340
+V LL+ A +H+T G T L A +GH + +VLL GA+++
Sbjct: 549 ELVKYLLASGAN-VHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
Score = 109 bits (262), Expect = 1e-22
Identities = 120/425 (28%), Positives = 189/425 (44%), Gaps = 38/425 (8%)
Query: 665 RSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHI 724
RS+ A G V + LL +G SV+ T + + L +A + + + LL A+V
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 266
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLL 784
RG K TPL A+ D L+LL A N + G T + A G + + +LL
Sbjct: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHD-ADVNSQSATGNTALTYACAGGFVDIVKVLL 325
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD 844
+G + + G TPL A + ++ R L+ DH G ++T +
Sbjct: 326 NEGANIEDHNE-------NGHTPLMEAASAGHVEVARVLL----DH-GAGINT----HSN 369
Query: 845 EDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNND 904
E SAL AC +V+ L+E GAD +T H TA + G+ +
Sbjct: 370 EFKESALTLACY---------KGHLDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVE 419
Query: 905 VMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRS 964
V ++ D +N +PL +A GH++L L+ A ++ + EG +
Sbjct: 420 VARLLL------DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYT 473
Query: 965 ALHLAAEHGYLQVCDALLTNKAFINSKARNGR-TALHLAAMNGYAHLVKFLIRDHNAMID 1023
L AA G+ ++ LL A IN++ + TAL LA G++ + FLI+ A D
Sbjct: 474 PLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIK---AGAD 530
Query: 1024 VLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
+ L TPL A+ G +E+ K LL GAN+ AT G + A +N +++V + LQ
Sbjct: 531 I-ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589
Query: 1084 QHPNL 1088
+L
Sbjct: 590 AGADL 594
Score = 107 bits (258), Expect = 3e-22
Identities = 101/382 (26%), Positives = 165/382 (43%), Gaps = 28/382 (7%)
Query: 1132 DSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT-L 1190
D+ L A G + VR L+ G S + G + + LA G+ + V+ + + +
Sbjct: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG------------VSLVPV 1238
K +TPL A+ G + V+ LL H V S++ TG V +V V
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLH-DADVNSQSATGNTALTYACAGGFVDIVKV 323
Query: 1239 L---GA------ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFG 1289
L GA E+G TPL AA G+ V R+LL+ G + SNE + L LAC+
Sbjct: 324 LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH-GAGINTHSNEFKESALTLACYK 382
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP 1349
GH+ +V LL A+ H TD T L A GH ++ +LL GA++N + +P
Sbjct: 383 GHLDMVRFLLEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 441
Query: 1350 LHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLM 1409
L AA GH+ + LL E GA+ + + P+ AA E H +++ LL + + +
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
Query: 1410 DDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKERAKDLIAAG 1469
++ + + C + + +F++ + A ++ + + E K L+A+G
Sbjct: 502 EETQETALTLACCGGFSE--VADFLIKAGADIELGCSTPLMEAS-QEGHLELVKYLLASG 558
Query: 1470 KQCEXXXXXXXXXXXXXDSAGH 1491
GH
Sbjct: 559 ANVHATTATGDTALTYACENGH 580
Score = 101 bits (242), Expect = 3e-20
Identities = 118/425 (27%), Positives = 190/425 (44%), Gaps = 45/425 (10%)
Query: 736 IAARIPDGDKCALM-LLKSGAGPNKATEDGMTPVHVAAKFG--NLATLVLLLEDGGDPLR 792
+A DGD A+ LL G N+ TE+G + + +A G LA ++L + + R
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED-R 267
Query: 793 KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALH 852
K I TPL A DIV+ L+ D +S + G +AL
Sbjct: 268 GNKGDI-------TPLMAASSGGYLDIVKLLLLHDADVNSQSAT----------GNTALT 310
Query: 853 YACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAH 912
YAC ++ VK L+ GA++ + H T A AG+ +V ++ H
Sbjct: 311 YACAGGFVDI---------VKVLLNEGANIEDHNENGH-TPLMEAASAGHVEVARVLLDH 360
Query: 913 ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEH 972
A ++ N + L +AC++GH+ +V LL A + E +AL A
Sbjct: 361 --GAGIN---THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 415
Query: 973 GYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTP 1032
G+++V LL + A +N A + + L LAA G+ L LI + A ++ + + TP
Sbjct: 416 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI-ERGANLEEVNDEGYTP 474
Query: 1033 LHLAAASGQIEVCKLLLELGANIDA-TDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
L AA G E+ LLL GANI+A T+E + + A +SEV ++ ++ +
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG 534
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
+T A+ +G +++++ L+ +G T L A E GH DV VL
Sbjct: 535 C----STPLMEASQEGHLELVKYLL---ASGANVHATTATGDTALTYACENGHTDVADVL 587
Query: 1152 VRAGA 1156
++AGA
Sbjct: 588 LQAGA 592
Score = 64.1 bits (149), Expect = 5e-09
Identities = 46/172 (26%), Positives = 82/172 (47%), Gaps = 3/172 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G + L+A +G + +LL A+ + + + G+TAL A VD+ ++L++ G
Sbjct: 270 KGDITPLMAASSGGYLDIVKLLLLHDAD-VNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAAENGHAAII 180
A ++ N G TPL AA+ G + + A NE + + + LA GH ++
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFE 232
L + A +T + T + A ++GH + A +L G ++MP FE
Sbjct: 389 RFLLEA-GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
Score = 62.1 bits (144), Expect = 2e-08
Identities = 51/161 (31%), Positives = 79/161 (49%), Gaps = 4/161 (2%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G+ MVR LL A ++ K T TAL A V++AR+L+D GA V+
Sbjct: 376 LTLACYKGHLDMVRFLLEAGADQEHK--TDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ ++PL +AA G L AN ++E TP+ AA GH ++ LL +
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Query: 187 FKASIFERTKD-GSTLMHIASLNGHADCAMMLFKKGVYLHM 226
A+I +T++ T + +A G ++ A L K G + +
Sbjct: 494 -GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL 533
Score = 53.6 bits (123), Expect = 7e-06
Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 2/165 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL+ A AG+ + R LL + ++AL LA + +DM R L++
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNE-FKESALTLACYKGHLDMVRFLLEA 394
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA + T L A +G + + A + + +P+ LAA GH +
Sbjct: 395 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 454
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
LL ++ A++ E +G T + A+ GH + +L +G ++
Sbjct: 455 ALLIER-GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Score = 52.8 bits (121), Expect = 1e-05
Identities = 48/194 (24%), Positives = 87/194 (44%), Gaps = 13/194 (6%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA GHV + L+++G +++ ++ YT L A +V LL GA+++ + +
Sbjct: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
+ET L +A + A L+K+GA TP+ A++ G+L + LL G +
Sbjct: 505 QETALTLAC-CGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGAN 560
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD--EDG 847
T TG+T L AC + D+ L++ D + ++ +D +
Sbjct: 561 VHATT-------ATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDPAKHQ 613
Query: 848 ASALHYACKVTKEE 861
ACK+ ++E
Sbjct: 614 VRVAFDACKLLRKE 627
Score = 52.4 bits (120), Expect = 2e-05
Identities = 42/125 (33%), Positives = 56/125 (44%), Gaps = 4/125 (3%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V G PL+ A G++ MV LL AQ A T +TAL LA ++A L+
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVA-LLLAQGANINAQTEETQETALTLACCGGFSEVADFLI 525
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
GA ++ TPL A+ EG LVKY AN T + A ENGH
Sbjct: 526 KAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTD 582
Query: 179 IIELL 183
+ ++L
Sbjct: 583 VADVL 587
Score = 51.6 bits (118), Expect = 3e-05
Identities = 45/160 (28%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G+ + L+ + L+ G T L AAR +M +L+ GA ++
Sbjct: 441 PLTLAACGGHVELAALLI--ERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Query: 126 A-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A T +T L +A G + + ++A A I + TP+ A++ GH +++ L
Sbjct: 499 AQTEETQETALTLACCGGFSEVADFL--IKAGADI-ELGCSTPLMEASQEGHLELVKYLL 555
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
A++ T G T + A NGH D A +L + G L
Sbjct: 556 AS-GANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/162 (25%), Positives = 68/162 (41%), Gaps = 3/162 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGD-TALHLAARRRDVDMARILVD 119
+ G+ L LA AG + + LL+ + + GD T L A+ +D+ ++L+
Sbjct: 236 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK--GDITPLMAASSGGYLDIVKLLLL 293
Query: 120 YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
+ A V++ + G T L A A G +VK AN + TP+ AA GH +
Sbjct: 294 HDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEV 353
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+L D + + + +A GH D L + G
Sbjct: 354 ARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
Score = 45.6 bits (103), Expect = 0.002
Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 2/121 (1%)
Query: 110 DVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE-DRTPM 168
DV+ R L+D G V+ G++ L +A + G L + + AN N+ D TP+
Sbjct: 217 DVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPL 276
Query: 169 HLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
A+ G+ I++LL A + ++ G+T + A G D +L +G + N
Sbjct: 277 MAASSGGYLDIVKLLL-LHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 229 K 229
+
Sbjct: 336 E 336
Score = 41.5 bits (93), Expect = 0.031
Identities = 38/130 (29%), Positives = 62/130 (47%), Gaps = 8/130 (6%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY-TALHIAVESCKPAVVETLLGYGA 720
+G + AAR GH ++ LL +G +++ T + TAL +A V + L+ GA
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529
Query: 721 DVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
D+ + TPL A++ +G + LL SGA + T G T + A + G+
Sbjct: 530 DIEL----GCSTPLMEASQ--EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 583
Query: 780 LVLLLEDGGD 789
+LL+ G D
Sbjct: 584 ADVLLQAGAD 593
Score = 38.3 bits (85), Expect = 0.29
Identities = 22/60 (36%), Positives = 34/60 (56%), Gaps = 2/60 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL+ A + G+ +V+ LL++ + ATT GDTAL A D+A +L+ GA +D
Sbjct: 538 PLMEASQEGHLELVKYLLAS--GANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
Score = 37.9 bits (84), Expect = 0.39
Identities = 28/111 (25%), Positives = 49/111 (44%), Gaps = 1/111 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
L AE H+ + L A + G V LL +G +N + G + L A AG
Sbjct: 190 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 249
Query: 1358 HLNVVKLLCESGASPKSETNL-NCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
+ + ++L A+ + N + P+ A+S + D+++ LL + D S
Sbjct: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
>BC009909-1|AAH09909.1| 627|Homo sapiens ankyrin repeat and KH domain
containing 1 protein.
Length = 627
Score = 134 bits (323), Expect = 4e-30
Identities = 119/411 (28%), Positives = 184/411 (44%), Gaps = 22/411 (5%)
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
V+ RS L A G + LL +N G + L LA GY L + L+ H
Sbjct: 204 VDTRS-LAEACSDGDVNAVRKLLDECRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 262
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
+ D TPL A++ G +++ KLLL A++++ G + A + ++V+
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLA 1139
+ L + N + ++G+T AA G V+V L+ G+ + N+ +S L LA
Sbjct: 323 VLLNEGAN-IEDHNENGHTPLMEAASAGHVEVARVLLDHG-AGINTHSNEFKESA-LTLA 379
Query: 1140 AEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGL 1199
GH D+VR L+ AGA + TA+ A GH V ++ +
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
+PL +AA G E L+ G +L V + G TPL AA G+E +
Sbjct: 440 SPLTLAACGGHVELAALLIER-----------GANLEEV--NDEGYTPLMEAAREGHEEM 486
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
V LLL + G +A + E L LAC GG + L+ A++ + T L
Sbjct: 487 VALLL-AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI----ELGCSTPLME 541
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
AS GH ++V+ LL GA ++AT G T L A + GH +V +L ++GA
Sbjct: 542 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 592
Score = 130 bits (314), Expect = 5e-29
Identities = 120/413 (29%), Positives = 189/413 (45%), Gaps = 25/413 (6%)
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A +G + V+ L+ D ++ T + ++ L LA ++G E+ ++LL + AN++
Sbjct: 212 ACSDGDVNAVRKLL-DECRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 270
Query: 1062 GQ-KPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDR 1120
G P+ AA+ Y ++V+L L H V + + GNT A G V +++ L+ +
Sbjct: 271 GDITPLMAASSGGYLDIVKLLLL-HDADVNSQSATGNTALTYACAGGFVDIVKVLL--NE 327
Query: 1121 TGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASC-TDENRAGLTAVHLAAEHGHTN 1179
I N+ N TPL AA GH +V RVL+ GA T N +A+ LA GH +
Sbjct: 328 GANIEDHNE-NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386
Query: 1180 VLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVL 1239
++ + + T L A G E R LL +G + +
Sbjct: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD-----------SGAQVN--M 433
Query: 1240 GAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLL 1299
A+S +PL LAA G+ + LL+ G + N+ GY PL A GH +V LLL
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIER-GANLEEV-NDEGYTPLMEAAREGHEEMVALLL 491
Query: 1300 SRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
++ A + T+ +T L +A G ++ + L+ GA+I TPL A++ GHL
Sbjct: 492 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHL 548
Query: 1360 NVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDK 1412
+VK L SGA+ + T + +A H DV + LL D D K
Sbjct: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 601
Score = 122 bits (294), Expect = 1e-26
Identities = 115/408 (28%), Positives = 179/408 (43%), Gaps = 27/408 (6%)
Query: 936 ACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNG 995
AC G + V LL V+ EG S L LA GY ++ LL A + + G
Sbjct: 212 ACSDGDVNAVRKLLDECRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 996 R-TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
T L A+ GY +VK L+ H+A ++ + T L A A G +++ K+LL GAN
Sbjct: 272 DITPLMAASSGGYLDIVKLLLL-HDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 330
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
I+ +E G P+ AA + EV ++ L + + + + +A +G + ++
Sbjct: 331 IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRF 390
Query: 1115 LMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
L++ G T L A GH +V R+L+ +GA + + + LAA
Sbjct: 391 LLE---AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447
Query: 1175 HGHTNV--LDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
GH + L + R N ++ + G TPL AA G E V LL+ G
Sbjct: 448 GGHVELAALLIERGANLEEVNDE--GYTPLMEAAREGHEEMVALLLAQ-----------G 494
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHM 1292
+ + E+ T L LA G V L+ AG + + PL A GH+
Sbjct: 495 AN-INAQTEETQETALTLACCGGFSEVADFLI-KAGADIELGCS----TPLMEASQEGHL 548
Query: 1293 SIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN 1340
+V LL+ A +H+T G T L A +GH + +VLL GA+++
Sbjct: 549 ELVKYLLASGAN-VHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
Score = 105 bits (253), Expect = 1e-21
Identities = 119/425 (28%), Positives = 188/425 (44%), Gaps = 38/425 (8%)
Query: 665 RSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHI 724
RS+ A G V + LL + SV+ T + + L +A + + + LL A+V
Sbjct: 207 RSLAEACSDGDVNAVRKLLDECRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 266
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLL 784
RG K TPL A+ D L+LL A N + G T + A G + + +LL
Sbjct: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHD-ADVNSQSATGNTALTYACAGGFVDIVKVLL 325
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD 844
+G + + G TPL A + ++ R L+ DH G ++T +
Sbjct: 326 NEGANIEDHNE-------NGHTPLMEAASAGHVEVARVLL----DH-GAGINT----HSN 369
Query: 845 EDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNND 904
E SAL AC +V+ L+E GAD +T H TA + G+ +
Sbjct: 370 EFKESALTLACY---------KGHLDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVE 419
Query: 905 VMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRS 964
V ++ D +N +PL +A GH++L L+ A ++ + EG +
Sbjct: 420 VARLLL------DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYT 473
Query: 965 ALHLAAEHGYLQVCDALLTNKAFINSKARNGR-TALHLAAMNGYAHLVKFLIRDHNAMID 1023
L AA G+ ++ LL A IN++ + TAL LA G++ + FLI+ A D
Sbjct: 474 PLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIK---AGAD 530
Query: 1024 VLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
+ L TPL A+ G +E+ K LL GAN+ AT G + A +N +++V + LQ
Sbjct: 531 I-ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589
Query: 1084 QHPNL 1088
+L
Sbjct: 590 AGADL 594
Score = 104 bits (249), Expect = 4e-21
Identities = 100/382 (26%), Positives = 164/382 (42%), Gaps = 28/382 (7%)
Query: 1132 DSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT-L 1190
D+ L A G + VR L+ S + G + + LA G+ + V+ + + +
Sbjct: 205 DTRSLAEACSDGDVNAVRKLLDECRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG------------VSLVPV 1238
K +TPL A+ G + V+ LL H V S++ TG V +V V
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLH-DADVNSQSATGNTALTYACAGGFVDIVKV 323
Query: 1239 L---GA------ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFG 1289
L GA E+G TPL AA G+ V R+LL+ G + SNE + L LAC+
Sbjct: 324 LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH-GAGINTHSNEFKESALTLACYK 382
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP 1349
GH+ +V LL A+ H TD T L A GH ++ +LL GA++N + +P
Sbjct: 383 GHLDMVRFLLEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 441
Query: 1350 LHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLM 1409
L AA GH+ + LL E GA+ + + P+ AA E H +++ LL + + +
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
Query: 1410 DDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKERAKDLIAAG 1469
++ + + C + + +F++ + A ++ + + E K L+A+G
Sbjct: 502 EETQETALTLACCGGFSE--VADFLIKAGADIELGCSTPLMEAS-QEGHLELVKYLLASG 558
Query: 1470 KQCEXXXXXXXXXXXXXDSAGH 1491
GH
Sbjct: 559 ANVHATTATGDTALTYACENGH 580
Score = 97.9 bits (233), Expect = 3e-19
Identities = 117/425 (27%), Positives = 189/425 (44%), Gaps = 45/425 (10%)
Query: 736 IAARIPDGDKCALM-LLKSGAGPNKATEDGMTPVHVAAKFG--NLATLVLLLEDGGDPLR 792
+A DGD A+ LL N+ TE+G + + +A G LA ++L + + R
Sbjct: 209 LAEACSDGDVNAVRKLLDECRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED-R 267
Query: 793 KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALH 852
K I TPL A DIV+ L+ D +S + G +AL
Sbjct: 268 GNKGDI-------TPLMAASSGGYLDIVKLLLLHDADVNSQSAT----------GNTALT 310
Query: 853 YACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAH 912
YAC ++ VK L+ GA++ + H T A AG+ +V ++ H
Sbjct: 311 YACAGGFVDI---------VKVLLNEGANIEDHNENGH-TPLMEAASAGHVEVARVLLDH 360
Query: 913 ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEH 972
A ++ N + L +AC++GH+ +V LL A + E +AL A
Sbjct: 361 --GAGIN---THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 415
Query: 973 GYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTP 1032
G+++V LL + A +N A + + L LAA G+ L LI + A ++ + + TP
Sbjct: 416 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI-ERGANLEEVNDEGYTP 474
Query: 1033 LHLAAASGQIEVCKLLLELGANIDA-TDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
L AA G E+ LLL GANI+A T+E + + A +SEV ++ ++ +
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG 534
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
+T A+ +G +++++ L+ +G T L A E GH DV VL
Sbjct: 535 C----STPLMEASQEGHLELVKYLL---ASGANVHATTATGDTALTYACENGHTDVADVL 587
Query: 1152 VRAGA 1156
++AGA
Sbjct: 588 LQAGA 592
Score = 64.1 bits (149), Expect = 5e-09
Identities = 46/172 (26%), Positives = 82/172 (47%), Gaps = 3/172 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G + L+A +G + +LL A+ + + + G+TAL A VD+ ++L++ G
Sbjct: 270 KGDITPLMAASSGGYLDIVKLLLLHDAD-VNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAAENGHAAII 180
A ++ N G TPL AA+ G + + A NE + + + LA GH ++
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFE 232
L + A +T + T + A ++GH + A +L G ++MP FE
Sbjct: 389 RFLLEA-GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
Score = 62.1 bits (144), Expect = 2e-08
Identities = 51/161 (31%), Positives = 79/161 (49%), Gaps = 4/161 (2%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G+ MVR LL A ++ K T TAL A V++AR+L+D GA V+
Sbjct: 376 LTLACYKGHLDMVRFLLEAGADQEHK--TDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ ++PL +AA G L AN ++E TP+ AA GH ++ LL +
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Query: 187 FKASIFERTKD-GSTLMHIASLNGHADCAMMLFKKGVYLHM 226
A+I +T++ T + +A G ++ A L K G + +
Sbjct: 494 -GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL 533
Score = 53.6 bits (123), Expect = 7e-06
Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 2/165 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL+ A AG+ + R LL + ++AL LA + +DM R L++
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNE-FKESALTLACYKGHLDMVRFLLEA 394
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA + T L A +G + + A + + +P+ LAA GH +
Sbjct: 395 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 454
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
LL ++ A++ E +G T + A+ GH + +L +G ++
Sbjct: 455 ALLIER-GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Score = 52.8 bits (121), Expect = 1e-05
Identities = 48/194 (24%), Positives = 87/194 (44%), Gaps = 13/194 (6%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA GHV + L+++G +++ ++ YT L A +V LL GA+++ + +
Sbjct: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
+ET L +A + A L+K+GA TP+ A++ G+L + LL G +
Sbjct: 505 QETALTLAC-CGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGAN 560
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD--EDG 847
T TG+T L AC + D+ L++ D + ++ +D +
Sbjct: 561 VHATT-------ATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDPAKHQ 613
Query: 848 ASALHYACKVTKEE 861
ACK+ ++E
Sbjct: 614 VRVAFDACKLLRKE 627
Score = 52.4 bits (120), Expect = 2e-05
Identities = 42/125 (33%), Positives = 56/125 (44%), Gaps = 4/125 (3%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V G PL+ A G++ MV LL AQ A T +TAL LA ++A L+
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVA-LLLAQGANINAQTEETQETALTLACCGGFSEVADFLI 525
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
GA ++ TPL A+ EG LVKY AN T + A ENGH
Sbjct: 526 KAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTD 582
Query: 179 IIELL 183
+ ++L
Sbjct: 583 VADVL 587
Score = 51.6 bits (118), Expect = 3e-05
Identities = 45/160 (28%), Positives = 73/160 (45%), Gaps = 7/160 (4%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA G+ + L+ + L+ G T L AAR +M +L+ GA ++
Sbjct: 441 PLTLAACGGHVELAALLI--ERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Query: 126 A-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
A T +T L +A G + + ++A A I + TP+ A++ GH +++ L
Sbjct: 499 AQTEETQETALTLACCGGFSEVADFL--IKAGADI-ELGCSTPLMEASQEGHLELVKYLL 555
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
A++ T G T + A NGH D A +L + G L
Sbjct: 556 AS-GANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/162 (25%), Positives = 68/162 (41%), Gaps = 3/162 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGD-TALHLAARRRDVDMARILVD 119
+ G+ L LA AG + + LL+ + + GD T L A+ +D+ ++L+
Sbjct: 236 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK--GDITPLMAASSGGYLDIVKLLLL 293
Query: 120 YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
+ A V++ + G T L A A G +VK AN + TP+ AA GH +
Sbjct: 294 HDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEV 353
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+L D + + + +A GH D L + G
Sbjct: 354 ARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
Score = 41.9 bits (94), Expect = 0.024
Identities = 31/121 (25%), Positives = 55/121 (45%), Gaps = 2/121 (1%)
Query: 110 DVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE-DRTPM 168
DV+ R L+D V+ G++ L +A + G L + + AN N+ D TP+
Sbjct: 217 DVNAVRKLLDECRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPL 276
Query: 169 HLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
A+ G+ I++LL A + ++ G+T + A G D +L +G + N
Sbjct: 277 MAASSGGYLDIVKLLL-LHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 229 K 229
+
Sbjct: 336 E 336
Score = 41.5 bits (93), Expect = 0.031
Identities = 38/130 (29%), Positives = 62/130 (47%), Gaps = 8/130 (6%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY-TALHIAVESCKPAVVETLLGYGA 720
+G + AAR GH ++ LL +G +++ T + TAL +A V + L+ GA
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529
Query: 721 DVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
D+ + TPL A++ +G + LL SGA + T G T + A + G+
Sbjct: 530 DIEL----GCSTPLMEASQ--EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 583
Query: 780 LVLLLEDGGD 789
+LL+ G D
Sbjct: 584 ADVLLQAGAD 593
Score = 38.3 bits (85), Expect = 0.29
Identities = 22/60 (36%), Positives = 34/60 (56%), Gaps = 2/60 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL+ A + G+ +V+ LL++ + ATT GDTAL A D+A +L+ GA +D
Sbjct: 538 PLMEASQEGHLELVKYLLAS--GANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
Score = 34.3 bits (75), Expect = 4.8
Identities = 27/111 (24%), Positives = 48/111 (43%), Gaps = 1/111 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
L AE H+ + L A + G V LL + +N + G + L A AG
Sbjct: 190 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDECRSVNEHTEEGESLLCLACSAG 249
Query: 1358 HLNVVKLLCESGASPKSETNL-NCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
+ + ++L A+ + N + P+ A+S + D+++ LL + D S
Sbjct: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
>BC050529-1|AAH50529.1| 1050|Homo sapiens ankyrin repeat domain 27
(VPS9 domain) protein.
Length = 1050
Score = 133 bits (321), Expect = 7e-30
Identities = 120/440 (27%), Positives = 187/440 (42%), Gaps = 34/440 (7%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G TPL +A G L++ L++ A V+ D G + LHLA + GY V LL KA
Sbjct: 463 GHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASA 522
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLI--RDHNAMIDVLTLKKQTPLHLAAASGQIEVCK 1046
+ NG T LHLA G+ VK L+ + +D+ K TPLH+AA G V +
Sbjct: 523 EVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIE 582
Query: 1047 LLLELGANIDATDELGQKPIHAAAQNNYSEVVQ---LFLQQHPNLVMATTKDGNTCAHIA 1103
LL+ GA+ + + L + P+ A + V++ L ++ A +
Sbjct: 583 TLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSI 642
Query: 1104 AIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENR 1163
+ + S + R + + L A G ++VR L+ ++
Sbjct: 643 SQESSTSSFSSMSASSRQE--ETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAE 700
Query: 1164 AGLTAVHLAAEH----------GHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAET 1213
++A H + V S + ++S+ G +PLH+AA +G+A+
Sbjct: 701 DTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQD-GSSPLHVAALHGRADL 759
Query: 1214 VRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADA 1273
+ LL H A V PLHLA G+ VV+ LL+S
Sbjct: 760 IPLLLKHGANAGARNADQAV-------------PLHLACQQGHFQVVKCLLDSNA--KPN 804
Query: 1274 ASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLL 1333
+ +G PL AC GGH +V LLL A +++++ G T LH A H +VE+LL
Sbjct: 805 KKDLSGNTPLIYACSGGHHELVALLLQHGAS-INASNNKGNTALHEAVIEKHVFVVELLL 863
Query: 1334 GQGAEINATDKNGWTPLHCA 1353
GA + +K T + CA
Sbjct: 864 LHGASVQVLNKRQRTAVDCA 883
Score = 119 bits (286), Expect = 1e-25
Identities = 130/486 (26%), Positives = 206/486 (42%), Gaps = 29/486 (5%)
Query: 990 SKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL 1049
S+ G T LH+AA+ G A L+ L+ AM++ TPLHLA G V LLL
Sbjct: 458 SRDDRGHTPLHVAAVCGQASLIDLLV-SKGAMVNATDYHGATPLHLACQKGYQSVTLLLL 516
Query: 1050 ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ---QHPNLVMATTKDGNTCAHIAAIQ 1106
A+ + D G P+H A + + V+ + + L + K G+T HIAA
Sbjct: 517 HYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEK-GDTPLHIAARW 575
Query: 1107 GSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRV----LVRAGASCTDEN 1162
G VIE L++ + I +N+L + TPL+ A V+ R S
Sbjct: 576 GYQGVIETLLQNGASTEI--QNRLKE-TPLKCALNSKILSVMEAYHLSFERRQKSSEAPV 632
Query: 1163 RAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLG-LTPLHIAAYYGQAETVRELLSHV 1221
++ +V ++ T+ M +++ + K + L A G E VR LL
Sbjct: 633 QSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWT 692
Query: 1222 PGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYN 1281
++ T + P P A + + ++ + GV ++++G +
Sbjct: 693 EEDLEDAEDTVSAADPEFCHPLCQCPKCAPA---QKRLAKVPASGLGVNV---TSQDGSS 746
Query: 1282 PLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINA 1341
PLH+A G ++ LLL A + + LH+A GH+Q+V+ LL A+ N
Sbjct: 747 PLHVAALHGRADLIPLLLKHGANA-GARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNK 805
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
D +G TPL A GH +V LL + GAS + N + A E H V+E LL
Sbjct: 806 KDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLH 865
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPV----DTAAKLSNIYINLSTK 1457
Q L +R + C++ N I E + V P+ V D A Y+ + +
Sbjct: 866 GASVQVLNKRQRTAVD---CAE--QNSKIMELLQVVPSCVASLDDVAETDRKEYVTVKIR 920
Query: 1458 EKERAK 1463
+K +K
Sbjct: 921 KKWNSK 926
Score = 105 bits (252), Expect = 2e-21
Identities = 111/451 (24%), Positives = 193/451 (42%), Gaps = 37/451 (8%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA G +I+ L+ KG V+ T T LH+A + +V LL Y A
Sbjct: 463 GHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASA 522
Query: 723 HIRGGKQRETPLHIAARIPDGD--KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
++ TPLH+A D K + + E G TP+H+AA++G +
Sbjct: 523 EVQDNNGN-TPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVI 581
Query: 781 VLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVR-HLIEFVKDHKGESVSTAF 839
LL++G + ++ ETPL+ A S + ++ + + F + K
Sbjct: 582 ETLLQNGASTEIQNRL-------KETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQS 634
Query: 840 ----IDAVDEDGASALHYACKVT--KEEVK------------IPTADRQVVKCLIENGAD 881
+D++ ++ +++ + + +EE K + D ++V+ L+E +
Sbjct: 635 PQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLE-WTE 693
Query: 882 VSLQTRHNHETAF--HYCAIAGNNDVMTEMIAHISTADVSR-ALNRQNSIGWTPLLIACH 938
L+ + +A +C ++ S +N + G +PL +A
Sbjct: 694 EDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAAL 753
Query: 939 RGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTA 998
G L+ LL + A + + LHLA + G+ QV LL + A N K +G T
Sbjct: 754 HGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTP 813
Query: 999 LHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDAT 1058
L A G+ LV L++ H A I+ K T LH A + V +LLL GA++
Sbjct: 814 LIYACSGGHHELVALLLQ-HGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVL 872
Query: 1059 DELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
++ + + A QN S++++L LQ P+ V
Sbjct: 873 NKRQRTAVDCAEQN--SKIMEL-LQVVPSCV 900
Score = 91.1 bits (216), Expect = 4e-17
Identities = 101/413 (24%), Positives = 191/413 (46%), Gaps = 38/413 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKG-ES--VDVTTNDNYTALHIAVESCKPAVVETLLGY 718
+G +H A YGH + L+ ES +D+ T LHIA V+ETLL
Sbjct: 528 NGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQN 587
Query: 719 GADVHIRGGKQRETPLHIA--ARIPDGDKCALMLL----KSGAGPNKATEDGMTPVHVAA 772
GA I+ + +ETPL A ++I + + KS P ++ + + + +
Sbjct: 588 GASTEIQN-RLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQES 646
Query: 773 KFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKG 832
+ +++ +TK +V E L+ + ++VR+L+E+ ++
Sbjct: 647 STSSFSSM-----SASSRQEETKKDYREV---EKLLRAVADGDL-EMVRYLLEWTEEDLE 697
Query: 833 ESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHET 892
++ T + A D + H C+ K A +++ K + +G V++ T + +
Sbjct: 698 DAEDT--VSAADPEFC---HPLCQCPK----CAPAQKRLAK-VPASGLGVNV-TSQDGSS 746
Query: 893 AFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
H A+ G D++ ++ H + A A N ++ PL +AC +GH Q+V LL ++
Sbjct: 747 PLHVAALHGRADLIPLLLKHGANAG---ARNADQAV---PLHLACQQGHFQVVKCLLDSN 800
Query: 953 ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVK 1012
A+ + D+ G + L A G+ ++ LL + A IN+ G TALH A + + +V+
Sbjct: 801 AKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVE 860
Query: 1013 FLIRDHNAMIDVLTLKKQTPLHLAAASGQI-EVCKLLLELGANIDATDELGQK 1064
L+ H A + VL +++T + A + +I E+ +++ A++D E +K
Sbjct: 861 LLLL-HGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAETDRK 912
Score = 90.2 bits (214), Expect = 7e-17
Identities = 57/165 (34%), Positives = 90/165 (54%), Gaps = 6/165 (3%)
Query: 1235 LVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSI 1294
+ P + G TPLH+AA G +++ LL+ S G +A ++ +G PLHLAC G+ S+
Sbjct: 454 VTPFSRDDRGHTPLHVAAVCGQASLIDLLV-SKGAMVNA-TDYHGATPLHLACQKGYQSV 511
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAE---INATDKNGWTPLH 1351
LLL A D +G T LH+A T+GH V+ L+ E ++ ++ G TPLH
Sbjct: 512 TLLLLHYKASA-EVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLH 570
Query: 1352 CAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLE 1396
AA+ G+ V++ L ++GAS + + L P+ A + V+E
Sbjct: 571 IAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVME 615
Score = 73.7 bits (173), Expect = 6e-12
Identities = 111/484 (22%), Positives = 188/484 (38%), Gaps = 50/484 (10%)
Query: 757 PNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCM 816
P + G TP+HVAA G A+L+ LL G + T G TPL +AC+
Sbjct: 456 PFSRDDRGHTPLHVAAVCGQ-ASLIDLLVSKGAMVNATD------YHGATPLHLACQKGY 508
Query: 817 PDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLI 876
+ L+ + A + D +G + LH AC E+ V C +
Sbjct: 509 QSVTLLLLHY----------KASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRL 558
Query: 877 ENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIA 936
+ G +T H A G V+ ++ + ++ ++ QN + TPL A
Sbjct: 559 DIG-------NEKGDTPLHIAARWGYQGVIETLLQNGASTEI------QNRLKETPLKCA 605
Query: 937 CHR---GHMQLVNTLLTNHARVDVFDVEG--RSALHLAAEHGYLQVCDALLTNKAFINSK 991
+ M+ + + V+ RS ++ E +++ K
Sbjct: 606 LNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKK 665
Query: 992 ARNGRTALHLAAMNGYAHLVKFLI----RDHNAMIDVLTLKKQTPLH-LAAASGQIEVCK 1046
L A +G +V++L+ D D ++ H L K
Sbjct: 666 DYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQK 725
Query: 1047 LLLELGAN---IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIA 1103
L ++ A+ ++ T + G P+H AA + ++++ L L+ N A D H+A
Sbjct: 726 RLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGAN-AGARNADQAVPLHLA 784
Query: 1104 AIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENR 1163
QG +V++ L+ + + L+ +TPL A GGH ++V +L++ GAS N
Sbjct: 785 CQQGHFQVVKCLLD---SNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNN 841
Query: 1164 AGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPG 1223
G TA+H A H V++++ K T + A Q + ELL VP
Sbjct: 842 KGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAE---QNSKIMELLQVVPS 898
Query: 1224 TVKS 1227
V S
Sbjct: 899 CVAS 902
Score = 72.5 bits (170), Expect = 1e-11
Identities = 43/137 (31%), Positives = 67/137 (48%), Gaps = 2/137 (1%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G T LH+AA + +LV GA+V+AT+ G TPLH+A +G + + +A+A
Sbjct: 463 GHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASA 522
Query: 158 AIADNEDRTPMHLAAENGHAAIIELLA--DKFKASIFERTKDGSTLMHIASLNGHADCAM 215
+ DN TP+HLA GH ++ L D + + G T +HIA+ G+
Sbjct: 523 EVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIE 582
Query: 216 MLFKKGVYLHMPNKYFE 232
L + G + N+ E
Sbjct: 583 TLLQNGASTEIQNRLKE 599
Score = 71.7 bits (168), Expect = 3e-11
Identities = 49/159 (30%), Positives = 79/159 (49%), Gaps = 7/159 (4%)
Query: 1249 HLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHS 1308
H+A+ GN+ V LL+ D + +PL C + G L S S
Sbjct: 404 HIAS--GNQKEVERLLSQEDHDKDTV--QKMCHPLCF-CDDCEKLVSGRLNDPSVVTPFS 458
Query: 1309 TDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCES 1368
D G T LH+A+ G ++++L+ +GA +NATD +G TPLH A + G+ +V LL
Sbjct: 459 RDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHY 518
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
AS + + N P+ A + H D ++ L++ +D +S
Sbjct: 519 KASAEVQDNNGNTPLHLACTYGHEDCVKALVY--YDVES 555
Score = 71.3 bits (167), Expect = 3e-11
Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 6/146 (4%)
Query: 943 QLVNTLLTNHARVDVF--DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALH 1000
+LV+ L + + V F D G + LH+AA G + D L++ A +N+ +G T LH
Sbjct: 442 KLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLH 501
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLEL---GANIDA 1057
LA GY V L+ + A +V TPLHLA G + K L+ +D
Sbjct: 502 LACQKGY-QSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDI 560
Query: 1058 TDELGQKPIHAAAQNNYSEVVQLFLQ 1083
+E G P+H AA+ Y V++ LQ
Sbjct: 561 GNEKGDTPLHIAARWGYQGVIETLLQ 586
Score = 67.3 bits (157), Expect = 6e-10
Identities = 47/140 (33%), Positives = 72/140 (51%), Gaps = 6/140 (4%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
RG PL +A G S++ +LL ++ A + AT G T LHLA ++ + +L+ Y
Sbjct: 462 RGHTPLHVAAVCGQASLI-DLLVSKGA-MVNATDYHGATPLHLACQKGYQSVTLLLLHYK 519
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVK--YFYGVRA-NAAIADNEDRTPMHLAAENGHAA 178
A + + G TPLH+A G E VK +Y V + I + + TP+H+AA G+
Sbjct: 520 ASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQG 579
Query: 179 IIE-LLADKFKASIFERTKD 197
+IE LL + I R K+
Sbjct: 580 VIETLLQNGASTEIQNRLKE 599
Score = 62.9 bits (146), Expect = 1e-08
Identities = 58/219 (26%), Positives = 99/219 (45%), Gaps = 13/219 (5%)
Query: 1012 KFLIRDHNAMIDVLTLKKQTPLHLAAASG-QIEVCKLLLELGANIDATDELGQKPIHAAA 1070
+ ++ +++ +T L ASG Q EV +LL + + D QK H
Sbjct: 380 RLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVERLLSQEDHDKDTV----QKMCHPLC 435
Query: 1071 QNNYSEVVQLFLQQHPNLVMATTKD--GNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
+ E + P++V ++D G+T H+AA+ G +I+ L+ G +
Sbjct: 436 FCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVS---KGAMVNAT 492
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLD--VMRS 1186
+ +TPL LA + G+ V +L+ AS ++ G T +HLA +GH + + V
Sbjct: 493 DYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYD 552
Query: 1187 TNTLRIS-SKKLGLTPLHIAAYYGQAETVRELLSHVPGT 1224
+ R+ + G TPLHIAA +G + LL + T
Sbjct: 553 VESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGAST 591
Score = 62.9 bits (146), Expect = 1e-08
Identities = 40/139 (28%), Positives = 61/139 (43%), Gaps = 1/139 (0%)
Query: 91 LKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYF 150
+ T+ G + LH+AA D+ +L+ +GA A N PLH+A +G +VK
Sbjct: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
Query: 151 YGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
A D TP+ A GH ++ LL + ASI G+T +H A + H
Sbjct: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLL-QHGASINASNNKGNTALHEAVIEKH 855
Query: 211 ADCAMMLFKKGVYLHMPNK 229
+L G + + NK
Sbjct: 856 VFVVELLLLHGASVQVLNK 874
Score = 62.1 bits (144), Expect = 2e-08
Identities = 58/216 (26%), Positives = 92/216 (42%), Gaps = 14/216 (6%)
Query: 20 VRSPPANQQKDLQRLELSFIELNKERAKQKEWKKLIRDLVFQRGKVPLLLAVEAGNQSMV 79
V+SP + Q S ++Q+E KK R++ LL AV G+ MV
Sbjct: 632 VQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVE------KLLRAVADGDLEMV 685
Query: 80 RELL--SAQTAEQLKATTPAGDTAL-H-LAARRRDVDMARILVDY---GAVVDATNGAGQ 132
R LL + + E + T A D H L + + L G V+ T+ G
Sbjct: 686 RYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGS 745
Query: 133 TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIF 192
+PLH+AA G L+ ANA + + P+HLA + GH +++ L D A
Sbjct: 746 SPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDS-NAKPN 804
Query: 193 ERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
++ G+T + A GH + +L + G ++ N
Sbjct: 805 KKDLSGNTPLIYACSGGHHELVALLLQHGASINASN 840
Score = 50.4 bits (115), Expect = 7e-05
Identities = 37/122 (30%), Positives = 58/122 (47%), Gaps = 5/122 (4%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL LA + G QS+ LL + + +++ G+T LHLA D + LV Y
Sbjct: 496 GATPLHLACQKGYQSVTLLLLHYKASAEVQDNN--GNTPLHLACTYGHEDCVKALVYYDV 553
Query: 123 V---VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
+D N G TPLHIAA G + +++ A+ I + TP+ A + ++
Sbjct: 554 ESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSV 613
Query: 180 IE 181
+E
Sbjct: 614 ME 615
Score = 46.8 bits (106), Expect = 8e-04
Identities = 35/119 (29%), Positives = 59/119 (49%), Gaps = 4/119 (3%)
Query: 65 VPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVV 124
VPL LA + G+ +V+ LL + K + G+T L A ++ +L+ +GA +
Sbjct: 779 VPLHLACQQGHFQVVKCLLDSNAKPNKKDLS--GNTPLIYACSGGHHELVALLLQHGASI 836
Query: 125 DATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
+A+N G T LH A E +V+ A+ + + RT + A +N + I+ELL
Sbjct: 837 NASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQN--SKIMELL 893
Score = 44.8 bits (101), Expect = 0.003
Identities = 27/72 (37%), Positives = 36/72 (50%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K G + A GH ++ LLQ G S++ + N TALH AV VVE LL +
Sbjct: 806 KDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLH 865
Query: 719 GADVHIRGGKQR 730
GA V + +QR
Sbjct: 866 GASVQVLNKRQR 877
Score = 41.9 bits (94), Expect = 0.024
Identities = 27/82 (32%), Positives = 42/82 (51%), Gaps = 4/82 (4%)
Query: 661 FDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
+ GA +H A + G+ + LL S +V N+ T LH+A V+ L+ Y
Sbjct: 494 YHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDV 553
Query: 721 D---VHIRGGKQRETPLHIAAR 739
+ + I G ++ +TPLHIAAR
Sbjct: 554 ESCRLDI-GNEKGDTPLHIAAR 574
Score = 37.9 bits (84), Expect = 0.39
Identities = 19/57 (33%), Positives = 32/57 (56%), Gaps = 1/57 (1%)
Query: 161 DNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
D+ TP+H+AA G A++I+LL K A + G+T +H+A G+ ++L
Sbjct: 460 DDRGHTPLHVAAVCGQASLIDLLVSK-GAMVNATDYHGATPLHLACQKGYQSVTLLL 515
>AK054561-1|BAB70755.1| 1060|Homo sapiens FLJ00040 protein protein.
Length = 1060
Score = 133 bits (321), Expect = 7e-30
Identities = 120/440 (27%), Positives = 187/440 (42%), Gaps = 34/440 (7%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G TPL +A G L++ L++ A V+ D G + LHLA + GY V LL KA
Sbjct: 473 GHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASA 532
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLI--RDHNAMIDVLTLKKQTPLHLAAASGQIEVCK 1046
+ NG T LHLA G+ VK L+ + +D+ K TPLH+AA G V +
Sbjct: 533 EVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIE 592
Query: 1047 LLLELGANIDATDELGQKPIHAAAQNNYSEVVQ---LFLQQHPNLVMATTKDGNTCAHIA 1103
LL+ GA+ + + L + P+ A + V++ L ++ A +
Sbjct: 593 TLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSI 652
Query: 1104 AIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENR 1163
+ + S + R + + L A G ++VR L+ ++
Sbjct: 653 SQESSTSSFSSMSASSRQE--ETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAE 710
Query: 1164 AGLTAVHLAAEH----------GHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAET 1213
++A H + V S + ++S+ G +PLH+AA +G+A+
Sbjct: 711 DTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQD-GSSPLHVAALHGRADL 769
Query: 1214 VRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADA 1273
+ LL H A V PLHLA G+ VV+ LL+S
Sbjct: 770 IPLLLKHGANAGARNADQAV-------------PLHLACQQGHFQVVKCLLDSNA--KPN 814
Query: 1274 ASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLL 1333
+ +G PL AC GGH +V LLL A +++++ G T LH A H +VE+LL
Sbjct: 815 KKDLSGNTPLIYACSGGHHELVALLLQHGAS-INASNNKGNTALHEAVIEKHVFVVELLL 873
Query: 1334 GQGAEINATDKNGWTPLHCA 1353
GA + +K T + CA
Sbjct: 874 LHGASVQVLNKRQRTAVDCA 893
Score = 119 bits (286), Expect = 1e-25
Identities = 130/486 (26%), Positives = 206/486 (42%), Gaps = 29/486 (5%)
Query: 990 SKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL 1049
S+ G T LH+AA+ G A L+ L+ AM++ TPLHLA G V LLL
Sbjct: 468 SRDDRGHTPLHVAAVCGQASLIDLLV-SKGAMVNATDYHGATPLHLACQKGYQSVTLLLL 526
Query: 1050 ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ---QHPNLVMATTKDGNTCAHIAAIQ 1106
A+ + D G P+H A + + V+ + + L + K G+T HIAA
Sbjct: 527 HYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEK-GDTPLHIAARW 585
Query: 1107 GSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRV----LVRAGASCTDEN 1162
G VIE L++ + I +N+L + TPL+ A V+ R S
Sbjct: 586 GYQGVIETLLQNGASTEI--QNRLKE-TPLKCALNSKILSVMEAYHLSFERRQKSSEAPV 642
Query: 1163 RAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLG-LTPLHIAAYYGQAETVRELLSHV 1221
++ +V ++ T+ M +++ + K + L A G E VR LL
Sbjct: 643 QSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWT 702
Query: 1222 PGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYN 1281
++ T + P P A + + ++ + GV ++++G +
Sbjct: 703 EEDLEDAEDTVSAADPEFCHPLCQCPKCAPA---QKRLAKVPASGLGVNV---TSQDGSS 756
Query: 1282 PLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINA 1341
PLH+A G ++ LLL A + + LH+A GH+Q+V+ LL A+ N
Sbjct: 757 PLHVAALHGRADLIPLLLKHGANA-GARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNK 815
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
D +G TPL A GH +V LL + GAS + N + A E H V+E LL
Sbjct: 816 KDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLH 875
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPV----DTAAKLSNIYINLSTK 1457
Q L +R + C++ N I E + V P+ V D A Y+ + +
Sbjct: 876 GASVQVLNKRQRTAVD---CAE--QNSKIMELLQVVPSCVASLDDVAETDRKEYVTVKIR 930
Query: 1458 EKERAK 1463
+K +K
Sbjct: 931 KKWNSK 936
Score = 105 bits (252), Expect = 2e-21
Identities = 111/451 (24%), Positives = 193/451 (42%), Gaps = 37/451 (8%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA G +I+ L+ KG V+ T T LH+A + +V LL Y A
Sbjct: 473 GHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASA 532
Query: 723 HIRGGKQRETPLHIAARIPDGD--KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
++ TPLH+A D K + + E G TP+H+AA++G +
Sbjct: 533 EVQDNNGN-TPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVI 591
Query: 781 VLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVR-HLIEFVKDHKGESVSTAF 839
LL++G + ++ ETPL+ A S + ++ + + F + K
Sbjct: 592 ETLLQNGASTEIQNRL-------KETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQS 644
Query: 840 ----IDAVDEDGASALHYACKVT--KEEVK------------IPTADRQVVKCLIENGAD 881
+D++ ++ +++ + + +EE K + D ++V+ L+E +
Sbjct: 645 PQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLE-WTE 703
Query: 882 VSLQTRHNHETAF--HYCAIAGNNDVMTEMIAHISTADVSR-ALNRQNSIGWTPLLIACH 938
L+ + +A +C ++ S +N + G +PL +A
Sbjct: 704 EDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAAL 763
Query: 939 RGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTA 998
G L+ LL + A + + LHLA + G+ QV LL + A N K +G T
Sbjct: 764 HGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTP 823
Query: 999 LHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDAT 1058
L A G+ LV L++ H A I+ K T LH A + V +LLL GA++
Sbjct: 824 LIYACSGGHHELVALLLQ-HGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVL 882
Query: 1059 DELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
++ + + A QN S++++L LQ P+ V
Sbjct: 883 NKRQRTAVDCAEQN--SKIMEL-LQVVPSCV 910
Score = 91.1 bits (216), Expect = 4e-17
Identities = 101/413 (24%), Positives = 191/413 (46%), Gaps = 38/413 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKG-ES--VDVTTNDNYTALHIAVESCKPAVVETLLGY 718
+G +H A YGH + L+ ES +D+ T LHIA V+ETLL
Sbjct: 538 NGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQN 597
Query: 719 GADVHIRGGKQRETPLHIA--ARIPDGDKCALMLL----KSGAGPNKATEDGMTPVHVAA 772
GA I+ + +ETPL A ++I + + KS P ++ + + + +
Sbjct: 598 GASTEIQN-RLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQES 656
Query: 773 KFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKG 832
+ +++ +TK +V E L+ + ++VR+L+E+ ++
Sbjct: 657 STSSFSSM-----SASSRQEETKKDYREV---EKLLRAVADGDL-EMVRYLLEWTEEDLE 707
Query: 833 ESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHET 892
++ T + A D + H C+ K A +++ K + +G V++ T + +
Sbjct: 708 DAEDT--VSAADPEFC---HPLCQCPK----CAPAQKRLAK-VPASGLGVNV-TSQDGSS 756
Query: 893 AFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
H A+ G D++ ++ H + A A N ++ PL +AC +GH Q+V LL ++
Sbjct: 757 PLHVAALHGRADLIPLLLKHGANAG---ARNADQAV---PLHLACQQGHFQVVKCLLDSN 810
Query: 953 ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVK 1012
A+ + D+ G + L A G+ ++ LL + A IN+ G TALH A + + +V+
Sbjct: 811 AKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVE 870
Query: 1013 FLIRDHNAMIDVLTLKKQTPLHLAAASGQI-EVCKLLLELGANIDATDELGQK 1064
L+ H A + VL +++T + A + +I E+ +++ A++D E +K
Sbjct: 871 LLLL-HGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAETDRK 922
Score = 90.2 bits (214), Expect = 7e-17
Identities = 57/165 (34%), Positives = 90/165 (54%), Gaps = 6/165 (3%)
Query: 1235 LVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSI 1294
+ P + G TPLH+AA G +++ LL+ S G +A ++ +G PLHLAC G+ S+
Sbjct: 464 VTPFSRDDRGHTPLHVAAVCGQASLIDLLV-SKGAMVNA-TDYHGATPLHLACQKGYQSV 521
Query: 1295 VGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAE---INATDKNGWTPLH 1351
LLL A D +G T LH+A T+GH V+ L+ E ++ ++ G TPLH
Sbjct: 522 TLLLLHYKASA-EVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLH 580
Query: 1352 CAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLE 1396
AA+ G+ V++ L ++GAS + + L P+ A + V+E
Sbjct: 581 IAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVME 625
Score = 73.7 bits (173), Expect = 6e-12
Identities = 111/484 (22%), Positives = 188/484 (38%), Gaps = 50/484 (10%)
Query: 757 PNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCM 816
P + G TP+HVAA G A+L+ LL G + T G TPL +AC+
Sbjct: 466 PFSRDDRGHTPLHVAAVCGQ-ASLIDLLVSKGAMVNATD------YHGATPLHLACQKGY 518
Query: 817 PDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLI 876
+ L+ + A + D +G + LH AC E+ V C +
Sbjct: 519 QSVTLLLLHY----------KASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRL 568
Query: 877 ENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIA 936
+ G +T H A G V+ ++ + ++ ++ QN + TPL A
Sbjct: 569 DIG-------NEKGDTPLHIAARWGYQGVIETLLQNGASTEI------QNRLKETPLKCA 615
Query: 937 CHR---GHMQLVNTLLTNHARVDVFDVEG--RSALHLAAEHGYLQVCDALLTNKAFINSK 991
+ M+ + + V+ RS ++ E +++ K
Sbjct: 616 LNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKK 675
Query: 992 ARNGRTALHLAAMNGYAHLVKFLI----RDHNAMIDVLTLKKQTPLH-LAAASGQIEVCK 1046
L A +G +V++L+ D D ++ H L K
Sbjct: 676 DYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQK 735
Query: 1047 LLLELGAN---IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIA 1103
L ++ A+ ++ T + G P+H AA + ++++ L L+ N A D H+A
Sbjct: 736 RLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGAN-AGARNADQAVPLHLA 794
Query: 1104 AIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENR 1163
QG +V++ L+ + + L+ +TPL A GGH ++V +L++ GAS N
Sbjct: 795 CQQGHFQVVKCLLD---SNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNN 851
Query: 1164 AGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPG 1223
G TA+H A H V++++ K T + A Q + ELL VP
Sbjct: 852 KGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAE---QNSKIMELLQVVPS 908
Query: 1224 TVKS 1227
V S
Sbjct: 909 CVAS 912
Score = 72.5 bits (170), Expect = 1e-11
Identities = 43/137 (31%), Positives = 67/137 (48%), Gaps = 2/137 (1%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G T LH+AA + +LV GA+V+AT+ G TPLH+A +G + + +A+A
Sbjct: 473 GHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASA 532
Query: 158 AIADNEDRTPMHLAAENGHAAIIELLA--DKFKASIFERTKDGSTLMHIASLNGHADCAM 215
+ DN TP+HLA GH ++ L D + + G T +HIA+ G+
Sbjct: 533 EVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIE 592
Query: 216 MLFKKGVYLHMPNKYFE 232
L + G + N+ E
Sbjct: 593 TLLQNGASTEIQNRLKE 609
Score = 71.7 bits (168), Expect = 3e-11
Identities = 49/159 (30%), Positives = 79/159 (49%), Gaps = 7/159 (4%)
Query: 1249 HLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHS 1308
H+A+ GN+ V LL+ D + +PL C + G L S S
Sbjct: 414 HIAS--GNQKEVERLLSQEDHDKDTV--QKMCHPLCF-CDDCEKLVSGRLNDPSVVTPFS 468
Query: 1309 TDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCES 1368
D G T LH+A+ G ++++L+ +GA +NATD +G TPLH A + G+ +V LL
Sbjct: 469 RDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHY 528
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
AS + + N P+ A + H D ++ L++ +D +S
Sbjct: 529 KASAEVQDNNGNTPLHLACTYGHEDCVKALVY--YDVES 565
Score = 71.3 bits (167), Expect = 3e-11
Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 6/146 (4%)
Query: 943 QLVNTLLTNHARVDVF--DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALH 1000
+LV+ L + + V F D G + LH+AA G + D L++ A +N+ +G T LH
Sbjct: 452 KLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLH 511
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLEL---GANIDA 1057
LA GY V L+ + A +V TPLHLA G + K L+ +D
Sbjct: 512 LACQKGY-QSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDI 570
Query: 1058 TDELGQKPIHAAAQNNYSEVVQLFLQ 1083
+E G P+H AA+ Y V++ LQ
Sbjct: 571 GNEKGDTPLHIAARWGYQGVIETLLQ 596
Score = 67.3 bits (157), Expect = 6e-10
Identities = 47/140 (33%), Positives = 72/140 (51%), Gaps = 6/140 (4%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
RG PL +A G S++ +LL ++ A + AT G T LHLA ++ + +L+ Y
Sbjct: 472 RGHTPLHVAAVCGQASLI-DLLVSKGA-MVNATDYHGATPLHLACQKGYQSVTLLLLHYK 529
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVK--YFYGVRA-NAAIADNEDRTPMHLAAENGHAA 178
A + + G TPLH+A G E VK +Y V + I + + TP+H+AA G+
Sbjct: 530 ASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQG 589
Query: 179 IIE-LLADKFKASIFERTKD 197
+IE LL + I R K+
Sbjct: 590 VIETLLQNGASTEIQNRLKE 609
Score = 62.9 bits (146), Expect = 1e-08
Identities = 58/219 (26%), Positives = 99/219 (45%), Gaps = 13/219 (5%)
Query: 1012 KFLIRDHNAMIDVLTLKKQTPLHLAAASG-QIEVCKLLLELGANIDATDELGQKPIHAAA 1070
+ ++ +++ +T L ASG Q EV +LL + + D QK H
Sbjct: 390 RLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVERLLSQEDHDKDTV----QKMCHPLC 445
Query: 1071 QNNYSEVVQLFLQQHPNLVMATTKD--GNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
+ E + P++V ++D G+T H+AA+ G +I+ L+ G +
Sbjct: 446 FCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVS---KGAMVNAT 502
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLD--VMRS 1186
+ +TPL LA + G+ V +L+ AS ++ G T +HLA +GH + + V
Sbjct: 503 DYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYD 562
Query: 1187 TNTLRIS-SKKLGLTPLHIAAYYGQAETVRELLSHVPGT 1224
+ R+ + G TPLHIAA +G + LL + T
Sbjct: 563 VESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGAST 601
Score = 62.9 bits (146), Expect = 1e-08
Identities = 40/139 (28%), Positives = 61/139 (43%), Gaps = 1/139 (0%)
Query: 91 LKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYF 150
+ T+ G + LH+AA D+ +L+ +GA A N PLH+A +G +VK
Sbjct: 747 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 806
Query: 151 YGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGH 210
A D TP+ A GH ++ LL + ASI G+T +H A + H
Sbjct: 807 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLL-QHGASINASNNKGNTALHEAVIEKH 865
Query: 211 ADCAMMLFKKGVYLHMPNK 229
+L G + + NK
Sbjct: 866 VFVVELLLLHGASVQVLNK 884
Score = 62.1 bits (144), Expect = 2e-08
Identities = 58/216 (26%), Positives = 92/216 (42%), Gaps = 14/216 (6%)
Query: 20 VRSPPANQQKDLQRLELSFIELNKERAKQKEWKKLIRDLVFQRGKVPLLLAVEAGNQSMV 79
V+SP + Q S ++Q+E KK R++ LL AV G+ MV
Sbjct: 642 VQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVE------KLLRAVADGDLEMV 695
Query: 80 RELL--SAQTAEQLKATTPAGDTAL-H-LAARRRDVDMARILVDY---GAVVDATNGAGQ 132
R LL + + E + T A D H L + + L G V+ T+ G
Sbjct: 696 RYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGS 755
Query: 133 TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIF 192
+PLH+AA G L+ ANA + + P+HLA + GH +++ L D A
Sbjct: 756 SPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDS-NAKPN 814
Query: 193 ERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
++ G+T + A GH + +L + G ++ N
Sbjct: 815 KKDLSGNTPLIYACSGGHHELVALLLQHGASINASN 850
Score = 50.4 bits (115), Expect = 7e-05
Identities = 37/122 (30%), Positives = 58/122 (47%), Gaps = 5/122 (4%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL LA + G QS+ LL + + +++ G+T LHLA D + LV Y
Sbjct: 506 GATPLHLACQKGYQSVTLLLLHYKASAEVQDNN--GNTPLHLACTYGHEDCVKALVYYDV 563
Query: 123 V---VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
+D N G TPLHIAA G + +++ A+ I + TP+ A + ++
Sbjct: 564 ESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSV 623
Query: 180 IE 181
+E
Sbjct: 624 ME 625
Score = 46.8 bits (106), Expect = 8e-04
Identities = 35/119 (29%), Positives = 59/119 (49%), Gaps = 4/119 (3%)
Query: 65 VPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVV 124
VPL LA + G+ +V+ LL + K + G+T L A ++ +L+ +GA +
Sbjct: 789 VPLHLACQQGHFQVVKCLLDSNAKPNKKDLS--GNTPLIYACSGGHHELVALLLQHGASI 846
Query: 125 DATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
+A+N G T LH A E +V+ A+ + + RT + A +N + I+ELL
Sbjct: 847 NASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQN--SKIMELL 903
Score = 44.8 bits (101), Expect = 0.003
Identities = 27/72 (37%), Positives = 36/72 (50%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K G + A GH ++ LLQ G S++ + N TALH AV VVE LL +
Sbjct: 816 KDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLH 875
Query: 719 GADVHIRGGKQR 730
GA V + +QR
Sbjct: 876 GASVQVLNKRQR 887
Score = 41.9 bits (94), Expect = 0.024
Identities = 27/82 (32%), Positives = 42/82 (51%), Gaps = 4/82 (4%)
Query: 661 FDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
+ GA +H A + G+ + LL S +V N+ T LH+A V+ L+ Y
Sbjct: 504 YHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDV 563
Query: 721 D---VHIRGGKQRETPLHIAAR 739
+ + I G ++ +TPLHIAAR
Sbjct: 564 ESCRLDI-GNEKGDTPLHIAAR 584
Score = 37.9 bits (84), Expect = 0.39
Identities = 19/57 (33%), Positives = 32/57 (56%), Gaps = 1/57 (1%)
Query: 161 DNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
D+ TP+H+AA G A++I+LL K A + G+T +H+A G+ ++L
Sbjct: 470 DDRGHTPLHVAAVCGQASLIDLLVSK-GAMVNATDYHGATPLHLACQKGYQSVTLLL 525
>AL133620-1|CAB63746.1| 1031|Homo sapiens hypothetical protein
protein.
Length = 1031
Score = 119 bits (287), Expect = 1e-25
Identities = 117/421 (27%), Positives = 195/421 (46%), Gaps = 33/421 (7%)
Query: 872 VKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWT 931
+K L+E DV + +T A GN +++ E+I + + N ++ WT
Sbjct: 21 LKALLEKCKDVD-ERNECGQTPLMIAAEQGNLEIVKELIKNGANC------NLEDLDNWT 73
Query: 932 PLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSK 991
L+ A GH+ +V LL ++ D+ G +AL A G V + LL++ A N
Sbjct: 74 ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGA--NPS 131
Query: 992 ARNGRTALH---LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
+ +++ AA G+A +V L++ + A ++ TPL AA G +E K L
Sbjct: 132 VTGLQYSVYPIIWAAGRGHADIVHLLLQ-NGAKVNCSDKYGTTPLVWAARKGHLECVKHL 190
Query: 1049 LELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGS 1108
L +GA++D + A + Y++ V+ L+++PN V T KDGNT IA+ +G
Sbjct: 191 LAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPN-VNLTDKDGNTALMIASKEGH 249
Query: 1109 VKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTA 1168
+++++L+ D ++ ++ D T L A GGH ++VR L++ A + TA
Sbjct: 250 TEIVQDLL--DAGTYVNIPDRSGD-TVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTA 306
Query: 1169 VHLAAEHGH-TNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKS 1227
++ A E G+ T V D+++ I +K G TPL A E V LL
Sbjct: 307 LYWAVEKGNATMVRDILQCNPDTEICTKD-GETPLIKATKMRNIEVVELLL--------- 356
Query: 1228 EAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLL-NSAGVQADAASNENGYNPLHLA 1286
+ VS V + G TPLH+A + + LLL N + N+ G P ++
Sbjct: 357 DKGAKVSAVD----KKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNID 412
Query: 1287 C 1287
C
Sbjct: 413 C 413
Score = 107 bits (258), Expect = 3e-22
Identities = 108/387 (27%), Positives = 186/387 (48%), Gaps = 22/387 (5%)
Query: 980 ALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAAS 1039
ALL ++ + G+T L +AA G +VK LI++ A ++ L T L A+
Sbjct: 23 ALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKN-GANCNLEDLDNWTALISASKE 81
Query: 1040 GQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTC 1099
G + + + LL+ G N++ D G + A ++VV+L L N + +
Sbjct: 82 GHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLQYSVYP 141
Query: 1100 AHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
AA +G ++ L++ ++ +K +TPL AA GH + V+ L+ GA
Sbjct: 142 IIWAAGRGHADIVHLLLQ--NGAKVNCSDKYG-TTPLVWAARKGHLECVKHLLAMGADVD 198
Query: 1160 DENRAGLTAVHLAAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
E +TA+ +A + G+T +V ++++ + ++ K G T L IA+ G E V++LL
Sbjct: 199 QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKD-GNTALMIASKEGHTEIVQDLL 257
Query: 1219 SHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNEN 1278
+A T V+ +P SG T L A G+ +VR LL D +N
Sbjct: 258 ---------DAGTYVN-IP---DRSGDTVLIGAVRGGHVEIVRALLQKY-ADIDIRGQDN 303
Query: 1279 GYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAE 1338
L+ A G+ ++V +L + + T + G+T L A+ + ++VE+LL +GA+
Sbjct: 304 -KTALYWAVEKGNATMVRDILQCNPDTEICT-KDGETPLIKATKMRNIEVVELLLDKGAK 361
Query: 1339 INATDKNGWTPLHCAAKAGHLNVVKLL 1365
++A DK G TPLH A + + +LL
Sbjct: 362 VSAVDKKGDTPLHIAIRGRSRKLAELL 388
Score = 107 bits (258), Expect = 3e-22
Identities = 98/359 (27%), Positives = 164/359 (45%), Gaps = 28/359 (7%)
Query: 1124 ISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDV 1183
+ RN+ TPL +AAE G+ ++V+ L++ GA+C E+ TA+ A++ GH ++++
Sbjct: 31 VDERNECGQ-TPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEE 89
Query: 1184 MRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-----VPGTVKSEAPT------- 1231
+ G T L A Y G+ + V LLSH V G S P
Sbjct: 90 LLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLQYSVYPIIWAAGRG 149
Query: 1232 GVSLVPVL---GAES------GLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNP 1282
+V +L GA+ G TPL AA G+ V+ LL + G D N
Sbjct: 150 HADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLL-AMGADVDQ-EGANSMTA 207
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINAT 1342
L +A GG+ V +L R+ + + TD+ G T L IAS GH ++V+ LL G +N
Sbjct: 208 LIVAVKGGYTQSVKEILKRNPNV-NLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIP 266
Query: 1343 DKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKE 1402
D++G T L A + GH+ +V+ L + A N +++A + + ++ +L
Sbjct: 267 DRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCN 326
Query: 1403 HDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKER 1461
DT+ D ++ + NI + E +L A V K + ++++ + + R
Sbjct: 327 PDTEICTKDGE---TPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSR 382
Score = 106 bits (254), Expect = 1e-21
Identities = 109/429 (25%), Positives = 198/429 (46%), Gaps = 40/429 (9%)
Query: 750 LLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQ 809
LL+ ++ E G TP+ +AA+ GNL + L+++G + C + + T L
Sbjct: 24 LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGAN-------CNLEDLDNWTALI 76
Query: 810 MACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADR 869
A + IV L++ + ++ D G +AL +AC + +V
Sbjct: 77 SASKEGHVHIVEELLKCGVN----------LEHRDMGGWTALMWACYKGRTDV------- 119
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
V+ L+ +GA+ S+ + A G+ D++ H+ + ++ +N + G
Sbjct: 120 --VELLLSHGANPSVTGLQYSVYPIIWAAGRGHADIV-----HLLLQNGAK-VNCSDKYG 171
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
TPL+ A +GH++ V LL A VD +AL +A + GY Q +L +N
Sbjct: 172 TTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVN 231
Query: 990 SKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL 1049
++G TAL +A+ G+ +V+ L+ D +++ T L A G +E+ + LL
Sbjct: 232 LTDKDGNTALMIASKEGHTEIVQDLL-DAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALL 290
Query: 1050 ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSV 1109
+ A+ID + + ++ A + + +V+ LQ +P+ + TKDG T A ++
Sbjct: 291 QKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEIC-TKDGETPLIKATKMRNI 349
Query: 1110 KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR---AGASCTDENRAGL 1166
+V+E L+ D+ +SA +K D TPL +A G + +L+R G N+AG
Sbjct: 350 EVVELLL--DKGAKVSAVDKKGD-TPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGE 406
Query: 1167 TAVHLAAEH 1175
T ++ H
Sbjct: 407 TPYNIDCSH 415
Score = 105 bits (253), Expect = 1e-21
Identities = 102/379 (26%), Positives = 167/379 (44%), Gaps = 19/379 (5%)
Query: 1030 QTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
QTPL +AA G +E+ K L++ GAN + D + +A++ + +V+ L+ NL
Sbjct: 39 QTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLE 98
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVR 1149
G T A +G V+E L+ ++ P+ AA GHAD+V
Sbjct: 99 HRDM-GGWTALMWACYKGRTDVVELLLSHGANPSVTGLQY--SVYPIIWAAGRGHADIVH 155
Query: 1150 VLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYG 1209
+L++ GA ++ G T + AA GH + + + +T L +A G
Sbjct: 156 LLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGG 215
Query: 1210 QAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGV 1269
++V+E+L P V+L + G T L +A+ G+ +V+ LL+ AG
Sbjct: 216 YTQSVKEILKRNPN---------VNLTD----KDGNTALMIASKEGHTEIVQDLLD-AGT 261
Query: 1270 QADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMV 1329
+ + +G L A GGH+ IV LL + A++ + KT L+ A G+ MV
Sbjct: 262 YVNIP-DRSGDTVLIGAVRGGHVEIVRALLQKYADI-DIRGQDNKTALYWAVEKGNATMV 319
Query: 1330 EVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASE 1389
+L + K+G TPL A K ++ VV+LL + GA + P+ A
Sbjct: 320 RDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRG 379
Query: 1390 NHNDVLEYLLHKEHDTQSL 1408
+ E LL D + L
Sbjct: 380 RSRKLAELLLRNPKDGRLL 398
Score = 104 bits (249), Expect = 4e-21
Identities = 97/369 (26%), Positives = 171/369 (46%), Gaps = 14/369 (3%)
Query: 855 CKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHIS 914
C T + + ++VK LI+NGA+ +L+ N TA + G+ ++ E++
Sbjct: 37 CGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNW-TALISASKEGHVHIVEELL---- 91
Query: 915 TADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE-GRSALHLAAEHG 973
V+ L ++ GWT L+ AC++G +V LL++ A V ++ + AA G
Sbjct: 92 KCGVN--LEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLQYSVYPIIWAAGRG 149
Query: 974 YLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPL 1033
+ + LL N A +N + G T L AA G+ VK L+ A +D T L
Sbjct: 150 HADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLA-MGADVDQEGANSMTAL 208
Query: 1034 HLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT 1093
+A G + K +L+ N++ TD+ G + A++ ++E+VQ L V
Sbjct: 209 IVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDA-GTYVNIPD 267
Query: 1094 KDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR 1153
+ G+T A G V+++ L++ + I R + ++ T L A E G+A +VR +++
Sbjct: 268 RSGDTVLIGAVRGGHVEIVRALLQ--KYADIDIRGQ-DNKTALYWAVEKGNATMVRDILQ 324
Query: 1154 AGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAET 1213
+ G T + A + + V++++ + K G TPLHI A G++
Sbjct: 325 CNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHI-AIRGRSRK 383
Query: 1214 VRELLSHVP 1222
+ ELL P
Sbjct: 384 LAELLLRNP 392
Score = 89.4 bits (212), Expect = 1e-16
Identities = 110/429 (25%), Positives = 191/429 (44%), Gaps = 44/429 (10%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G + AA G++ I+ L++ G + ++ DN+TAL A + +VE LL G ++
Sbjct: 38 GQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNL 97
Query: 723 HIR--GGKQRETPLHIAARIPDGDKCALMLLKSGAGPN-KATEDGMTPVHVAAKFGNLAT 779
R GG T L A D L LL GA P+ + + P+ AA G+
Sbjct: 98 EHRDMGG---WTALMWACYKGRTDVVEL-LLSHGANPSVTGLQYSVYPIIWAAGRGHADI 153
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF 839
+ LLL++G KV D G TPL A R + V+HL+ D
Sbjct: 154 VHLLLQNG------AKVNCSDKY-GTTPLVWAARKGHLECVKHLLAMGAD---------- 196
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
VD++GA+++ T V + Q VK +++ +V+L T + TA +
Sbjct: 197 ---VDQEGANSM------TALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASK 246
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
G+ +++ +++ D +N + G T L+ A GH+++V LL +A +D+
Sbjct: 247 EGHTEIVQDLL------DAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRG 300
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
+ ++AL+ A E G + +L ++G T L A +V+ L+ D
Sbjct: 301 QDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLL-DKG 359
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLLL---ELGANIDATDELGQKPIHAAAQNNYSE 1076
A + + K TPLH+A ++ +LLL + G + ++ G+ P + + S
Sbjct: 360 AKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSI 419
Query: 1077 VVQLFLQQH 1085
+ Q+F +H
Sbjct: 420 LTQIFGARH 428
Score = 71.3 bits (167), Expect = 3e-11
Identities = 81/356 (22%), Positives = 160/356 (44%), Gaps = 34/356 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
D ++ +A++ GHV I+ LL+ G +++ +TAL A + VVE LL +GA+
Sbjct: 70 DNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGAN 129
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ G + P+ AA D +LL++GA N + + G TP+ AA+ G+L +
Sbjct: 130 PSVTGLQYSVYPIIWAAGRGHAD-IVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVK 188
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LL G D + T L +A + V+ +++ ++
Sbjct: 189 HLLAMGAD-------VDQEGANSMTALIVAVKGGYTQSVKEILK----------RNPNVN 231
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
D+DG +AL A K ++V+ L++ G V++ R + +T G
Sbjct: 232 LTDKDGNTALMIASK---------EGHTEIVQDLLDAGTYVNIPDR-SGDTVLIGAVRGG 281
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ +++ ++ + D+ R + + ++ W A +G+ +V +L + ++ +
Sbjct: 282 HVEIVRALLQKYADIDI-RGQDNKTALYW-----AVEKGNATMVRDILQCNPDTEICTKD 335
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRD 1017
G + L A + ++V + LL A +++ + G T LH+A L + L+R+
Sbjct: 336 GETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRN 391
Score = 64.1 bits (149), Expect = 5e-09
Identities = 50/176 (28%), Positives = 82/176 (46%), Gaps = 6/176 (3%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
+L + G L++A + G+ +V++LL A T + +GDT L A R V++ R
Sbjct: 231 NLTDKDGNTALMIASKEGHTEIVQDLLDAGT--YVNIPDRSGDTVLIGAVRGGHVEIVRA 288
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+ A +D +T L+ A +G+ +V+ + I + TP+ A + +
Sbjct: 289 LLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRN 348
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF---KKGVYLHMPNK 229
++ELL DK A + K G T +HIA A +L K G L+ PNK
Sbjct: 349 IEVVELLLDK-GAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNK 403
Score = 58.8 bits (136), Expect = 2e-07
Identities = 51/169 (30%), Positives = 77/169 (45%), Gaps = 11/169 (6%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DG ++ A++ GH I+ LL G V++ T L AV +V LL AD
Sbjct: 236 DGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYAD 295
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALM-LLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
+ IR G+ +T L+ A + G+ + +L+ T+DG TP+ A K N+ +
Sbjct: 296 IDIR-GQDNKTALYWA--VEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVV 352
Query: 781 VLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKD 829
LLL+ G KV D G+TPL +A R + L+ KD
Sbjct: 353 ELLLDKG------AKVSAVD-KKGDTPLHIAIRGRSRKLAELLLRNPKD 394
Score = 57.2 bits (132), Expect = 6e-07
Identities = 37/126 (29%), Positives = 64/126 (50%), Gaps = 3/126 (2%)
Query: 105 AARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED 164
AA R D+ +L+ GA V+ ++ G TPL AA +G VK+ + A+
Sbjct: 145 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 204
Query: 165 RTPMHLAAENGHA-AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
T + +A + G+ ++ E+L K ++ KDG+T + IAS GH + L G Y
Sbjct: 205 MTALIVAVKGGYTQSVKEIL--KRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY 262
Query: 224 LHMPNK 229
+++P++
Sbjct: 263 VNIPDR 268
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/159 (24%), Positives = 75/159 (47%), Gaps = 4/159 (2%)
Query: 1313 GKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASP 1372
G+T L IA+ G+ ++V+ L+ GA N D + WT L A+K GH+++V+ L + G +
Sbjct: 38 GQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNL 97
Query: 1373 KSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEE 1432
+ + +A + DV+E LL H + ++ ++ + + I
Sbjct: 98 EHRDMGGWTALMWACYKGRTDVVELLL--SHGANPSVTGLQYSVYPIIWAAGRGHADIVH 155
Query: 1433 FVLVSPAPVDTAAKLSNIYINLSTKE--KERAKDLIAAG 1469
+L + A V+ + K + + ++ E K L+A G
Sbjct: 156 LLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 194
Score = 51.6 bits (118), Expect = 3e-05
Identities = 44/160 (27%), Positives = 71/160 (44%), Gaps = 4/160 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ PL++A E GN +V+EL+ + TAL A++ V + L+ G
Sbjct: 38 GQTPLMIAAEQGNLEIVKELI--KNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGV 95
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRT-PMHLAAENGHAAIIE 181
++ + G T L A +G +V+ AN ++ + P+ AA GHA I+
Sbjct: 96 NLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLQYSVYPIIWAAGRGHADIVH 155
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
LL A + K G+T + A+ GH +C L G
Sbjct: 156 LLLQN-GAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 194
Score = 50.4 bits (115), Expect = 7e-05
Identities = 33/98 (33%), Positives = 47/98 (47%), Gaps = 1/98 (1%)
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
VD N GQTPL IAA +G+ +VK AN + D ++ T + A++ GH I+E L
Sbjct: 31 VDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEEL 90
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
K ++ R G T + A G D +L G
Sbjct: 91 L-KCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHG 127
Score = 45.2 bits (102), Expect = 0.003
Identities = 39/149 (26%), Positives = 61/149 (40%), Gaps = 3/149 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL+ A G+ V+ LL+ + TAL +A + + ++
Sbjct: 171 GTTPLVWAARKGHLECVKHLLAMGADVDQEGANSM--TALIVAVKGGYTQSVKEILKRNP 228
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+ T+ G T L IA+ EG +V+ I D T + A GH I+
Sbjct: 229 NVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRA 288
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHA 211
L K+ A I R +D T ++ A G+A
Sbjct: 289 LLQKY-ADIDIRGQDNKTALYWAVEKGNA 316
Score = 40.3 bits (90), Expect = 0.072
Identities = 23/71 (32%), Positives = 41/71 (57%)
Query: 1329 VEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAAS 1388
++ LL + +++ ++ G TPL AA+ G+L +VK L ++GA+ E N + A+
Sbjct: 21 LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
Query: 1389 ENHNDVLEYLL 1399
E H ++E LL
Sbjct: 81 EGHVHIVEELL 91
Score = 37.5 bits (83), Expect = 0.51
Identities = 36/160 (22%), Positives = 65/160 (40%), Gaps = 2/160 (1%)
Query: 71 VEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGA 130
VE N ++ LL + + + G T L +AA + ++++ + L+ GA + +
Sbjct: 13 VEEENIPALKALL--EKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLD 70
Query: 131 GQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKAS 190
T L A+ EG +V+ N D T + A G ++ELL
Sbjct: 71 NWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANP 130
Query: 191 IFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
+ + A+ GHAD +L + G ++ +KY
Sbjct: 131 SVTGLQYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKY 170
>AL158217-11|CAI22163.1| 854|Homo sapiens espin protein.
Length = 854
Score = 119 bits (286), Expect = 1e-25
Identities = 96/310 (30%), Positives = 144/310 (46%), Gaps = 12/310 (3%)
Query: 895 HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHA- 953
H+ A AG + ++ + +RA N G TP A GH+ + LL+
Sbjct: 41 HHAARAGKLHCLRFLVEEAALPAAARARN-----GATPAHDASATGHLACLQWLLSQGGC 95
Query: 954 RVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN-GRTALHLAAMNGYAHLVK 1012
RV D G + LHLAA G+ +V + LL + + A + G +H AA G ++
Sbjct: 96 RVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLR 155
Query: 1013 FLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL-ELGANIDATDELGQKPIHAAAQ 1071
L+ + ++ T TPL+LA G +EV + L+ E GA+ A G P+HAAAQ
Sbjct: 156 LLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQ 215
Query: 1072 NNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLN 1131
+S V+ + + KDG T H AA +G KV+ L+ G ISA L
Sbjct: 216 MGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHG--GEISA--DLW 271
Query: 1132 DSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLR 1191
TPL AAE G + ++LV GA +R G TA L+ +GH++ +R+ L
Sbjct: 272 GGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLRTVENLS 331
Query: 1192 ISSKKLGLTP 1201
+ + L P
Sbjct: 332 VEHRVLSRDP 341
Score = 118 bits (284), Expect = 2e-25
Identities = 82/272 (30%), Positives = 136/272 (50%), Gaps = 18/272 (6%)
Query: 1101 HIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVR-VLVRAGASCT 1159
H AA G + + L+ + + +A N +TP A+ GH ++ +L + G
Sbjct: 41 HHAARAGKLHCLRFLV--EEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
Query: 1160 DENRAGLTAVHLAAEHGHTNVLD-VMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
D++ +G T +HLAA GH V++ ++ ++ +G P+H AA G ++R L+
Sbjct: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
Query: 1219 SHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNEN 1278
H P V ++ ++G TPL+LA G+ V + L+ G A +++
Sbjct: 159 EHYPEGVNAQT------------KNGATPLYLACQEGHLEVTQYLVQECGADPHARAHD- 205
Query: 1279 GYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAE 1338
G PLH A GH ++ L+S + L D+ G T +H A++ GH +++ LL G E
Sbjct: 206 GMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGE 265
Query: 1339 INATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
I+A D G TPLH AA+ G L ++L +GA
Sbjct: 266 ISA-DLWGGTPLHDAAENGELECCQILVVNGA 296
Score = 105 bits (251), Expect = 2e-21
Identities = 89/334 (26%), Positives = 150/334 (44%), Gaps = 22/334 (6%)
Query: 1036 AAASGQIEVCKLLLELGA-NIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTK 1094
AA G+++V + L G D L P+H AA+ ++ +++ A +
Sbjct: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
Query: 1095 DGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLND-STPLQLAAEGGHADVVRVLVR 1153
+G T AH A+ G + ++ L+ G ++K N +T L LAA GH +VV L+
Sbjct: 69 NGATPAHDASATGHLACLQWLLS---QGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLH 125
Query: 1154 -AGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK-KLGLTPLHIAAYYGQA 1211
G T G +H AA G L ++ ++++ K G TPL++A G
Sbjct: 126 HGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHL 185
Query: 1212 ETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQA 1271
E + L+ P A G+TPLH AA G+ V+ L++ V
Sbjct: 186 EVTQYLVQECGAD------------PHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSL 233
Query: 1272 DAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEV 1331
+ +++G +H A GH ++ LL E+ S D G T LH A+ +G + ++
Sbjct: 234 -SEQDKDGATAMHFAASRGHTKVLSWLLLHGGEI--SADLWGGTPLHDAAENGELECCQI 290
Query: 1332 LLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
L+ GAE++ D++G+T + GH + + L
Sbjct: 291 LVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYL 324
Score = 94.3 bits (224), Expect = 4e-18
Identities = 105/373 (28%), Positives = 167/373 (44%), Gaps = 39/373 (10%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTAL--HIAVESCKPAVVETLLGYGADVHIRGG 727
AAR G + ++ +L G + + D AL H A + K + L+ A
Sbjct: 9 AARQGELDVLRSLHAAG-LLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARA 67
Query: 728 KQRETPLHIAARIPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNLATLVLLLE 785
+ TP H A+ G L L S G +D G T +H+AA+FG+ + LL
Sbjct: 68 RNGATPAHDASAT--GHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLH 125
Query: 786 DGG-DPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD 844
GG DP T + G P+ A +R L+E H E V+ A
Sbjct: 126 HGGGDPTAATDM-------GALPIHYAAAKGDFPSLRLLVE----HYPEGVN-----AQT 169
Query: 845 EDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNND 904
++GA+ L+ AC +E + V +C GAD + H+ T H A G++
Sbjct: 170 KNGATPLYLAC----QEGHLEVTQYLVQEC----GADPHARA-HDGMTPLHAAAQMGHSP 220
Query: 905 VMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRS 964
V+ ++ S DVS L+ Q+ G T + A RGH ++++ LL + + D+ G +
Sbjct: 221 VIVWLV---SCTDVS--LSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISA-DLWGGT 274
Query: 965 ALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
LH AAE+G L+ C L+ N A ++ + R+G TA L+ NG++H ++L N ++
Sbjct: 275 PLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLRTVENLSVEH 334
Query: 1025 LTLKKQTPLHLAA 1037
L + L A
Sbjct: 335 RVLSRDPSAELEA 347
Score = 80.6 bits (190), Expect = 6e-14
Identities = 54/158 (34%), Positives = 79/158 (50%), Gaps = 5/158 (3%)
Query: 1247 PLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELL 1306
P+H AA G + +R L+ A + A AA NG P H A GH++ + LLS+ +
Sbjct: 39 PVHHAARAGKLHCLRFLVEEAALPA-AARARNGATPAHDASATGHLACLQWLLSQGGCRV 97
Query: 1307 HSTDRHGKTGLHIASTHGHYQMVEVLL--GQGAEINATDKNGWTPLHCAAKAGHLNVVKL 1364
D G T LH+A+ GH ++V LL G G ATD G P+H AA G ++L
Sbjct: 98 QDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDM-GALPIHYAAAKGDFPSLRL 156
Query: 1365 LCES-GASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
L E ++T P++ A E H +V +YL+ +
Sbjct: 157 LVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQE 194
Score = 75.8 bits (178), Expect = 2e-12
Identities = 52/161 (32%), Positives = 75/161 (46%), Gaps = 3/161 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVD-YG 121
G L LA G+ +V LL + A T G +H AA + D R+LV+ Y
Sbjct: 104 GATVLHLAARFGHPEVVNWLLHHGGGDPT-AATDMGALPIHYAAAKGDFPSLRLLVEHYP 162
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYG-VRANAAIADNEDRTPMHLAAENGHAAII 180
V+A G TPL++A EG + +Y A+ ++ TP+H AA+ GH+ +I
Sbjct: 163 EGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVI 222
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L S+ E+ KDG+T MH A+ GH L G
Sbjct: 223 VWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHG 263
Score = 68.1 bits (159), Expect = 3e-10
Identities = 58/195 (29%), Positives = 87/195 (44%), Gaps = 18/195 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
+GA H A+ GH+ + LL Q G V N T LH+A P VV LL +G
Sbjct: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL-AT 779
P+H AA D L++ G N T++G TP+++A + G+L T
Sbjct: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF 839
L+ E G DP + +D G TPL A + ++ L+ S +
Sbjct: 189 QYLVQECGADPHARA----HD---GMTPLHAAAQMGHSPVIVWLV---------SCTDVS 232
Query: 840 IDAVDEDGASALHYA 854
+ D+DGA+A+H+A
Sbjct: 233 LSEQDKDGATAMHFA 247
Score = 64.9 bits (151), Expect = 3e-09
Identities = 48/169 (28%), Positives = 75/169 (44%), Gaps = 5/169 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV-DYG 121
G +P+ A G+ +R LL E + A T G T L+LA + +++ + LV + G
Sbjct: 138 GALPIHYAAAKGDFPSLR-LLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECG 196
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVR-ANAAIADNEDRTPMHLAAENGHAAII 180
A A G TPLH AA G P++ + + + D + T MH AA GH ++
Sbjct: 197 ADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVL 256
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L G T +H A+ NG +C +L G L + ++
Sbjct: 257 SWLL--LHGGEISADLWGGTPLHDAAENGELECCQILVVNGAELDVRDR 303
Score = 59.3 bits (137), Expect = 1e-07
Identities = 41/129 (31%), Positives = 65/129 (50%), Gaps = 5/129 (3%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCK---PAVVETL 715
K GA +H AAR+GH ++N LL G D T + AL I + K P++ +
Sbjct: 100 KDNSGATVLHLAARFGHPEVVNWLLHHGGG-DPTAATDMGALPIHYAAAKGDFPSLRLLV 158
Query: 716 LGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y V+ + K TPL++A + + ++ + GA P+ DGMTP+H AA+ G
Sbjct: 159 EHYPEGVNAQ-TKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMG 217
Query: 776 NLATLVLLL 784
+ +V L+
Sbjct: 218 HSPVIVWLV 226
Score = 56.4 bits (130), Expect = 1e-06
Identities = 45/158 (28%), Positives = 70/158 (44%), Gaps = 4/158 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL LA + G+ + + L+ A+ A G T LH AA+ + LV
Sbjct: 170 KNGATPLYLACQEGHLEVTQYLVQECGADP-HARAHDGMTPLHAAAQMGHSPVIVWLVSC 228
Query: 121 GAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
V + + G T +H AA+ G ++ + + AD TP+H AAENG
Sbjct: 229 TDVSLSEQDKDGATAMHFAASRGHTKVLSWLL-LHGGEISADLWGGTPLHDAAENGELEC 287
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
++L A + R +DG T ++ NGH+ C L
Sbjct: 288 CQILVVN-GAELDVRDRDGYTAADLSDFNGHSHCTRYL 324
Score = 44.4 bits (100), Expect = 0.004
Identities = 31/119 (26%), Positives = 54/119 (45%), Gaps = 2/119 (1%)
Query: 105 AARRRDVDMARILVDYGAVVDATNGA-GQTPLHIAAAEGDEPLVKYFYGVRA-NAAIADN 162
AAR+ ++D+ R L G + + P+H AA G +++ A AA
Sbjct: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
Query: 163 EDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
TP H A+ GH A ++ L + + ++ G+T++H+A+ GH + L G
Sbjct: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127
Score = 42.3 bits (95), Expect = 0.018
Identities = 39/144 (27%), Positives = 57/144 (39%), Gaps = 4/144 (2%)
Query: 70 AVEAGNQSMVRELLSAQTAEQLKATT--PAGDTALHLAARRRDVDMARILVDYGAVVDAT 127
A++A Q + L S A L + P +H AAR + R LV+ A+ A
Sbjct: 6 ALQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAA 65
Query: 128 NGA-GQTPLHIAAAEGDEPLVKYFYGVRA-NAAIADNEDRTPMHLAAENGHAAIIELLAD 185
G TP H A+A G +++ DN T +HLAA GH ++ L
Sbjct: 66 RARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLH 125
Query: 186 KFKASIFERTKDGSTLMHIASLNG 209
T G+ +H A+ G
Sbjct: 126 HGGGDPTAATDMGALPIHYAAAKG 149
Score = 33.9 bits (74), Expect = 6.3
Identities = 20/64 (31%), Positives = 33/64 (51%), Gaps = 1/64 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DGA ++H AA GH +++ LL G + T LH A E+ + + L+ GA+
Sbjct: 239 DGATAMHFAASRGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAE 297
Query: 722 VHIR 725
+ +R
Sbjct: 298 LDVR 301
>AL031848-3|CAI19773.1| 854|Homo sapiens espin protein.
Length = 854
Score = 119 bits (286), Expect = 1e-25
Identities = 96/310 (30%), Positives = 144/310 (46%), Gaps = 12/310 (3%)
Query: 895 HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHA- 953
H+ A AG + ++ + +RA N G TP A GH+ + LL+
Sbjct: 41 HHAARAGKLHCLRFLVEEAALPAAARARN-----GATPAHDASATGHLACLQWLLSQGGC 95
Query: 954 RVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN-GRTALHLAAMNGYAHLVK 1012
RV D G + LHLAA G+ +V + LL + + A + G +H AA G ++
Sbjct: 96 RVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLR 155
Query: 1013 FLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL-ELGANIDATDELGQKPIHAAAQ 1071
L+ + ++ T TPL+LA G +EV + L+ E GA+ A G P+HAAAQ
Sbjct: 156 LLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQ 215
Query: 1072 NNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLN 1131
+S V+ + + KDG T H AA +G KV+ L+ G ISA L
Sbjct: 216 MGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHG--GEISA--DLW 271
Query: 1132 DSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLR 1191
TPL AAE G + ++LV GA +R G TA L+ +GH++ +R+ L
Sbjct: 272 GGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLRTVENLS 331
Query: 1192 ISSKKLGLTP 1201
+ + L P
Sbjct: 332 VEHRVLSRDP 341
Score = 118 bits (284), Expect = 2e-25
Identities = 82/272 (30%), Positives = 136/272 (50%), Gaps = 18/272 (6%)
Query: 1101 HIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVR-VLVRAGASCT 1159
H AA G + + L+ + + +A N +TP A+ GH ++ +L + G
Sbjct: 41 HHAARAGKLHCLRFLV--EEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
Query: 1160 DENRAGLTAVHLAAEHGHTNVLD-VMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
D++ +G T +HLAA GH V++ ++ ++ +G P+H AA G ++R L+
Sbjct: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
Query: 1219 SHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNEN 1278
H P V ++ ++G TPL+LA G+ V + L+ G A +++
Sbjct: 159 EHYPEGVNAQT------------KNGATPLYLACQEGHLEVTQYLVQECGADPHARAHD- 205
Query: 1279 GYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAE 1338
G PLH A GH ++ L+S + L D+ G T +H A++ GH +++ LL G E
Sbjct: 206 GMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGE 265
Query: 1339 INATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
I+A D G TPLH AA+ G L ++L +GA
Sbjct: 266 ISA-DLWGGTPLHDAAENGELECCQILVVNGA 296
Score = 105 bits (251), Expect = 2e-21
Identities = 89/334 (26%), Positives = 150/334 (44%), Gaps = 22/334 (6%)
Query: 1036 AAASGQIEVCKLLLELGA-NIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTK 1094
AA G+++V + L G D L P+H AA+ ++ +++ A +
Sbjct: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
Query: 1095 DGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLND-STPLQLAAEGGHADVVRVLVR 1153
+G T AH A+ G + ++ L+ G ++K N +T L LAA GH +VV L+
Sbjct: 69 NGATPAHDASATGHLACLQWLLS---QGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLH 125
Query: 1154 -AGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK-KLGLTPLHIAAYYGQA 1211
G T G +H AA G L ++ ++++ K G TPL++A G
Sbjct: 126 HGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHL 185
Query: 1212 ETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQA 1271
E + L+ P A G+TPLH AA G+ V+ L++ V
Sbjct: 186 EVTQYLVQECGAD------------PHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSL 233
Query: 1272 DAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEV 1331
+ +++G +H A GH ++ LL E+ S D G T LH A+ +G + ++
Sbjct: 234 -SEQDKDGATAMHFAASRGHTKVLSWLLLHGGEI--SADLWGGTPLHDAAENGELECCQI 290
Query: 1332 LLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
L+ GAE++ D++G+T + GH + + L
Sbjct: 291 LVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYL 324
Score = 94.3 bits (224), Expect = 4e-18
Identities = 105/373 (28%), Positives = 167/373 (44%), Gaps = 39/373 (10%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTAL--HIAVESCKPAVVETLLGYGADVHIRGG 727
AAR G + ++ +L G + + D AL H A + K + L+ A
Sbjct: 9 AARQGELDVLRSLHAAG-LLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARA 67
Query: 728 KQRETPLHIAARIPDGDKCALMLLKSGAGPNKATED--GMTPVHVAAKFGNLATLVLLLE 785
+ TP H A+ G L L S G +D G T +H+AA+FG+ + LL
Sbjct: 68 RNGATPAHDASAT--GHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLH 125
Query: 786 DGG-DPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD 844
GG DP T + G P+ A +R L+E H E V+ A
Sbjct: 126 HGGGDPTAATDM-------GALPIHYAAAKGDFPSLRLLVE----HYPEGVN-----AQT 169
Query: 845 EDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNND 904
++GA+ L+ AC +E + V +C GAD + H+ T H A G++
Sbjct: 170 KNGATPLYLAC----QEGHLEVTQYLVQEC----GADPHARA-HDGMTPLHAAAQMGHSP 220
Query: 905 VMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRS 964
V+ ++ S DVS L+ Q+ G T + A RGH ++++ LL + + D+ G +
Sbjct: 221 VIVWLV---SCTDVS--LSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISA-DLWGGT 274
Query: 965 ALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
LH AAE+G L+ C L+ N A ++ + R+G TA L+ NG++H ++L N ++
Sbjct: 275 PLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLRTVENLSVEH 334
Query: 1025 LTLKKQTPLHLAA 1037
L + L A
Sbjct: 335 RVLSRDPSAELEA 347
Score = 80.6 bits (190), Expect = 6e-14
Identities = 54/158 (34%), Positives = 79/158 (50%), Gaps = 5/158 (3%)
Query: 1247 PLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELL 1306
P+H AA G + +R L+ A + A AA NG P H A GH++ + LLS+ +
Sbjct: 39 PVHHAARAGKLHCLRFLVEEAALPA-AARARNGATPAHDASATGHLACLQWLLSQGGCRV 97
Query: 1307 HSTDRHGKTGLHIASTHGHYQMVEVLL--GQGAEINATDKNGWTPLHCAAKAGHLNVVKL 1364
D G T LH+A+ GH ++V LL G G ATD G P+H AA G ++L
Sbjct: 98 QDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDM-GALPIHYAAAKGDFPSLRL 156
Query: 1365 LCES-GASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
L E ++T P++ A E H +V +YL+ +
Sbjct: 157 LVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQE 194
Score = 75.8 bits (178), Expect = 2e-12
Identities = 52/161 (32%), Positives = 75/161 (46%), Gaps = 3/161 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVD-YG 121
G L LA G+ +V LL + A T G +H AA + D R+LV+ Y
Sbjct: 104 GATVLHLAARFGHPEVVNWLLHHGGGDPT-AATDMGALPIHYAAAKGDFPSLRLLVEHYP 162
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYG-VRANAAIADNEDRTPMHLAAENGHAAII 180
V+A G TPL++A EG + +Y A+ ++ TP+H AA+ GH+ +I
Sbjct: 163 EGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVI 222
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L S+ E+ KDG+T MH A+ GH L G
Sbjct: 223 VWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHG 263
Score = 68.1 bits (159), Expect = 3e-10
Identities = 58/195 (29%), Positives = 87/195 (44%), Gaps = 18/195 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
+GA H A+ GH+ + LL Q G V N T LH+A P VV LL +G
Sbjct: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGG 128
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL-AT 779
P+H AA D L++ G N T++G TP+++A + G+L T
Sbjct: 129 GDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVT 188
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF 839
L+ E G DP + +D G TPL A + ++ L+ S +
Sbjct: 189 QYLVQECGADPHARA----HD---GMTPLHAAAQMGHSPVIVWLV---------SCTDVS 232
Query: 840 IDAVDEDGASALHYA 854
+ D+DGA+A+H+A
Sbjct: 233 LSEQDKDGATAMHFA 247
Score = 64.9 bits (151), Expect = 3e-09
Identities = 48/169 (28%), Positives = 75/169 (44%), Gaps = 5/169 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV-DYG 121
G +P+ A G+ +R LL E + A T G T L+LA + +++ + LV + G
Sbjct: 138 GALPIHYAAAKGDFPSLR-LLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECG 196
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVR-ANAAIADNEDRTPMHLAAENGHAAII 180
A A G TPLH AA G P++ + + + D + T MH AA GH ++
Sbjct: 197 ADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVL 256
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L G T +H A+ NG +C +L G L + ++
Sbjct: 257 SWLL--LHGGEISADLWGGTPLHDAAENGELECCQILVVNGAELDVRDR 303
Score = 59.3 bits (137), Expect = 1e-07
Identities = 41/129 (31%), Positives = 65/129 (50%), Gaps = 5/129 (3%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCK---PAVVETL 715
K GA +H AAR+GH ++N LL G D T + AL I + K P++ +
Sbjct: 100 KDNSGATVLHLAARFGHPEVVNWLLHHGGG-DPTAATDMGALPIHYAAAKGDFPSLRLLV 158
Query: 716 LGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y V+ + K TPL++A + + ++ + GA P+ DGMTP+H AA+ G
Sbjct: 159 EHYPEGVNAQ-TKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMG 217
Query: 776 NLATLVLLL 784
+ +V L+
Sbjct: 218 HSPVIVWLV 226
Score = 56.4 bits (130), Expect = 1e-06
Identities = 45/158 (28%), Positives = 70/158 (44%), Gaps = 4/158 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL LA + G+ + + L+ A+ A G T LH AA+ + LV
Sbjct: 170 KNGATPLYLACQEGHLEVTQYLVQECGADP-HARAHDGMTPLHAAAQMGHSPVIVWLVSC 228
Query: 121 GAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
V + + G T +H AA+ G ++ + + AD TP+H AAENG
Sbjct: 229 TDVSLSEQDKDGATAMHFAASRGHTKVLSWLL-LHGGEISADLWGGTPLHDAAENGELEC 287
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
++L A + R +DG T ++ NGH+ C L
Sbjct: 288 CQILVVN-GAELDVRDRDGYTAADLSDFNGHSHCTRYL 324
Score = 44.4 bits (100), Expect = 0.004
Identities = 31/119 (26%), Positives = 54/119 (45%), Gaps = 2/119 (1%)
Query: 105 AARRRDVDMARILVDYGAVVDATNGA-GQTPLHIAAAEGDEPLVKYFYGVRA-NAAIADN 162
AAR+ ++D+ R L G + + P+H AA G +++ A AA
Sbjct: 9 AARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAARAR 68
Query: 163 EDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
TP H A+ GH A ++ L + + ++ G+T++H+A+ GH + L G
Sbjct: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHG 127
Score = 42.3 bits (95), Expect = 0.018
Identities = 39/144 (27%), Positives = 57/144 (39%), Gaps = 4/144 (2%)
Query: 70 AVEAGNQSMVRELLSAQTAEQLKATT--PAGDTALHLAARRRDVDMARILVDYGAVVDAT 127
A++A Q + L S A L + P +H AAR + R LV+ A+ A
Sbjct: 6 ALQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAA 65
Query: 128 NGA-GQTPLHIAAAEGDEPLVKYFYGVRA-NAAIADNEDRTPMHLAAENGHAAIIELLAD 185
G TP H A+A G +++ DN T +HLAA GH ++ L
Sbjct: 66 RARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLH 125
Query: 186 KFKASIFERTKDGSTLMHIASLNG 209
T G+ +H A+ G
Sbjct: 126 HGGGDPTAATDMGALPIHYAAAKG 149
Score = 33.9 bits (74), Expect = 6.3
Identities = 20/64 (31%), Positives = 33/64 (51%), Gaps = 1/64 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DGA ++H AA GH +++ LL G + T LH A E+ + + L+ GA+
Sbjct: 239 DGATAMHFAASRGHTKVLSWLLLHGGEISADLWGG-TPLHDAAENGELECCQILVVNGAE 297
Query: 722 VHIR 725
+ +R
Sbjct: 298 LDVR 301
>BC117678-1|AAI17679.1| 581|Homo sapiens ANKHD1 protein protein.
Length = 581
Score = 117 bits (282), Expect = 4e-25
Identities = 88/296 (29%), Positives = 147/296 (49%), Gaps = 15/296 (5%)
Query: 871 VVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGW 930
+VK L+ + ADV+ Q+ + TA Y G D++ ++ + + N G
Sbjct: 287 IVKLLLLHDADVNSQSATGN-TALTYACAGGFVDIVKVLL------NEGANIEDHNENGH 339
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGR-SALHLAAEHGYLQVCDALLTNKAFIN 989
TPL+ A GH+++ LL + A ++ E + SAL LA G+L + LL A
Sbjct: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
Query: 990 SKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL 1049
K TAL A M+G+ + + L+ D A +++ ++PL LAA G +E+ LL+
Sbjct: 400 HKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVELAALLI 458
Query: 1050 ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSV 1109
E GAN++ ++ G P+ AA+ + E+V L L Q N+ T + T +A G
Sbjct: 459 ERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFS 518
Query: 1110 KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAG 1165
+V + L+K A +L STPL A++ GH ++V+ L+ +G + E+ G
Sbjct: 519 EVADFLIK------AGADIELGCSTPLMEASQEGHLELVKYLLASGQAGGHEDYFG 568
Score = 116 bits (280), Expect = 7e-25
Identities = 109/370 (29%), Positives = 173/370 (46%), Gaps = 25/370 (6%)
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A +G + V+ L+ D ++ T + ++ L LA ++G E+ ++LL + AN++
Sbjct: 212 ACSDGDVNAVRKLL-DEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 270
Query: 1062 GQ-KPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDR 1120
G P+ AA+ Y ++V+L L H V + + GNT A G V +++ L+ +
Sbjct: 271 GDITPLMAASSGGYLDIVKLLLL-HDADVNSQSATGNTALTYACAGGFVDIVKVLL--NE 327
Query: 1121 TGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASC-TDENRAGLTAVHLAAEHGHTN 1179
I N+ N TPL AA GH +V RVL+ GA T N +A+ LA GH +
Sbjct: 328 GANIEDHNE-NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386
Query: 1180 VLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVL 1239
++ + + T L A G E R LL +G + +
Sbjct: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD-----------SGAQVN--M 433
Query: 1240 GAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLL 1299
A+S +PL LAA G+ + LL+ G + N+ GY PL A GH +V LLL
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIER-GANLEEV-NDEGYTPLMEAAREGHEEMVALLL 491
Query: 1300 SRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
++ A + T+ +T L +A G ++ + L+ GA+I TPL A++ GHL
Sbjct: 492 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHL 548
Query: 1360 NVVKLLCESG 1369
+VK L SG
Sbjct: 549 ELVKYLLASG 558
Score = 112 bits (269), Expect = 1e-23
Identities = 101/330 (30%), Positives = 156/330 (47%), Gaps = 32/330 (9%)
Query: 1093 TKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
T++G + +A G ++ + L+ + R D TPL A+ GG+ D+V++L+
Sbjct: 235 TEEGESLLCLACSAGYYELAQVLLAMHAN--VEDRGNKGDITPLMAASSGGYLDIVKLLL 292
Query: 1153 RAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAE 1212
A ++ G TA+ A G +++ V+ + + G TPL AA G E
Sbjct: 293 LHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVE 352
Query: 1213 TVRELLSHVPG--TVKSE-APTGVSLVPVLG--------AESGL----------TPLHLA 1251
R LL H G T +E + ++L G E+G T L A
Sbjct: 353 VARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEA 412
Query: 1252 AYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDR 1311
+G+ V RLLL+S G Q + + ++ +PL LA GGH+ + LL+ R A L D
Sbjct: 413 CMDGHVEVARLLLDS-GAQVNMPA-DSFESPLTLAACGGHVELAALLIERGANLEEVND- 469
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQGAEINA-TDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
G T L A+ GH +MV +LL QGA INA T++ T L A G V L ++GA
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529
Query: 1371 SPKSETNLNCA-PIWFAASENHNDVLEYLL 1399
+ L C+ P+ A+ E H ++++YLL
Sbjct: 530 ----DIELGCSTPLMEASQEGHLELVKYLL 555
Score = 100 bits (240), Expect = 5e-20
Identities = 82/287 (28%), Positives = 129/287 (44%), Gaps = 9/287 (3%)
Query: 936 ACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNG 995
AC G + V LL V+ EG S L LA GY ++ LL A + + G
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 996 R-TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
T L A+ GY +VK L+ H+A ++ + T L A A G +++ K+LL GAN
Sbjct: 272 DITPLMAASSGGYLDIVKLLLL-HDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 330
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
I+ +E G P+ AA + EV ++ L + + + + +A +G + ++
Sbjct: 331 IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRF 390
Query: 1115 LMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
L++ G T L A GH +V R+L+ +GA + + + LAA
Sbjct: 391 LLE---AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447
Query: 1175 HGHTNV--LDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
GH + L + R N ++ + G TPL AA G E V LL+
Sbjct: 448 GGHVELAALLIERGANLEEVNDE--GYTPLMEAAREGHEEMVALLLA 492
Score = 90.6 bits (215), Expect = 5e-17
Identities = 76/281 (27%), Positives = 123/281 (43%), Gaps = 16/281 (5%)
Query: 1132 DSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT-L 1190
D+ L A G + VR L+ G S + G + + LA G+ + V+ + + +
Sbjct: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHL 1250
K +TPL A+ G + V+ LL H V S++ TG T L
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLH-DADVNSQSATGN------------TALTY 311
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
A G ++V++LLN D NENG+ PL A GH+ + +LL A + ++
Sbjct: 312 ACAGGFVDIVKVLLNEGANIED--HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 369
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
++ L +A GH MV LL GA+ T L A GH+ V +LL +SGA
Sbjct: 370 EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 429
Query: 1371 SPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDD 1411
+ +P+ AA H ++ L+ + + + + D+
Sbjct: 430 QVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE 470
Score = 88.6 bits (210), Expect = 2e-16
Identities = 109/389 (28%), Positives = 170/389 (43%), Gaps = 38/389 (9%)
Query: 665 RSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHI 724
RS+ A G V + LL +G SV+ T + + L +A + + + LL A+V
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 266
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLL 784
RG K TPL A+ D L+LL A N + G T + A G + + +LL
Sbjct: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHD-ADVNSQSATGNTALTYACAGGFVDIVKVLL 325
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD 844
+G + + G TPL A + ++ R L+ DH G ++T +
Sbjct: 326 NEGANIEDHNE-------NGHTPLMEAASAGHVEVARVLL----DH-GAGINT----HSN 369
Query: 845 EDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNND 904
E SAL AC +V+ L+E GAD +T H TA + G+ +
Sbjct: 370 EFKESALTLACY---------KGHLDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVE 419
Query: 905 VMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRS 964
V ++ D +N +PL +A GH++L L+ A ++ + EG +
Sbjct: 420 VARLLL------DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYT 473
Query: 965 ALHLAAEHGYLQVCDALLTNKAFINSKARNGR-TALHLAAMNGYAHLVKFLIRDHNAMID 1023
L AA G+ ++ LL A IN++ + TAL LA G++ + FLI+ A D
Sbjct: 474 PLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIK---AGAD 530
Query: 1024 VLTLKKQTPLHLAAASGQIEVCKLLLELG 1052
+ L TPL A+ G +E+ K LL G
Sbjct: 531 I-ELGCSTPLMEASQEGHLELVKYLLASG 558
Score = 64.1 bits (149), Expect = 5e-09
Identities = 46/172 (26%), Positives = 82/172 (47%), Gaps = 3/172 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G + L+A +G + +LL A+ + + + G+TAL A VD+ ++L++ G
Sbjct: 270 KGDITPLMAASSGGYLDIVKLLLLHDAD-VNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAAENGHAAII 180
A ++ N G TPL AA+ G + + A NE + + + LA GH ++
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFE 232
L + A +T + T + A ++GH + A +L G ++MP FE
Sbjct: 389 RFLLEA-GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
Score = 62.1 bits (144), Expect = 2e-08
Identities = 51/161 (31%), Positives = 79/161 (49%), Gaps = 4/161 (2%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L LA G+ MVR LL A ++ K T TAL A V++AR+L+D GA V+
Sbjct: 376 LTLACYKGHLDMVRFLLEAGADQEHK--TDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ ++PL +AA G L AN ++E TP+ AA GH ++ LL +
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Query: 187 FKASIFERTKD-GSTLMHIASLNGHADCAMMLFKKGVYLHM 226
A+I +T++ T + +A G ++ A L K G + +
Sbjct: 494 -GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL 533
Score = 53.6 bits (123), Expect = 7e-06
Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 2/165 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL+ A AG+ + R LL + ++AL LA + +DM R L++
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNE-FKESALTLACYKGHLDMVRFLLEA 394
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA + T L A +G + + A + + +P+ LAA GH +
Sbjct: 395 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 454
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
LL ++ A++ E +G T + A+ GH + +L +G ++
Sbjct: 455 ALLIER-GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Score = 50.4 bits (115), Expect = 7e-05
Identities = 41/162 (25%), Positives = 68/162 (41%), Gaps = 3/162 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGD-TALHLAARRRDVDMARILVD 119
+ G+ L LA AG + + LL+ + + GD T L A+ +D+ ++L+
Sbjct: 236 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK--GDITPLMAASSGGYLDIVKLLLL 293
Query: 120 YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
+ A V++ + G T L A A G +VK AN + TP+ AA GH +
Sbjct: 294 HDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEV 353
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+L D + + + +A GH D L + G
Sbjct: 354 ARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
Score = 45.6 bits (103), Expect = 0.002
Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 2/121 (1%)
Query: 110 DVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE-DRTPM 168
DV+ R L+D G V+ G++ L +A + G L + + AN N+ D TP+
Sbjct: 217 DVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPL 276
Query: 169 HLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
A+ G+ I++LL A + ++ G+T + A G D +L +G + N
Sbjct: 277 MAASSGGYLDIVKLLL-LHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 229 K 229
+
Sbjct: 336 E 336
Score = 38.7 bits (86), Expect = 0.22
Identities = 33/91 (36%), Positives = 43/91 (47%), Gaps = 4/91 (4%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V G PL+ A G++ MV LL AQ A T +TAL LA ++A L+
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVA-LLLAQGANINAQTEETQETALTLACCGGFSEVADFLI 525
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKY 149
GA ++ TPL A+ EG LVKY
Sbjct: 526 KAGADIEL---GCSTPLMEASQEGHLELVKY 553
Score = 37.9 bits (84), Expect = 0.39
Identities = 28/111 (25%), Positives = 49/111 (44%), Gaps = 1/111 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
L AE H+ + L A + G V LL +G +N + G + L A AG
Sbjct: 190 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 249
Query: 1358 HLNVVKLLCESGASPKSETNL-NCAPIWFAASENHNDVLEYLLHKEHDTQS 1407
+ + ++L A+ + N + P+ A+S + D+++ LL + D S
Sbjct: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
>AL159174-1|CAI39609.1| 692|Homo sapiens ankyrin repeat domain 6
protein.
Length = 692
Score = 114 bits (274), Expect = 4e-24
Identities = 88/290 (30%), Positives = 138/290 (47%), Gaps = 9/290 (3%)
Query: 933 LLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKA 992
LL+A ++G + V L+ ARV V GR+ LHLAA G+L V LL ++ +
Sbjct: 14 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
Query: 993 RNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELG 1052
+TALH A + G ++ LI + +D T LH A+ G + KLL++ G
Sbjct: 73 DGDQTALHRATVVGNTEIIAALIHE-GCALDRQDKDGNTALHEASWHGFSQSAKLLIKAG 131
Query: 1053 ANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVI 1112
AN+ A ++ G +H A QN++S+ ++ L + G+TC H+AA + +I
Sbjct: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNA-GDTCLHVAARYNHLSII 190
Query: 1113 EELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA 1172
L+ + + +N+ D T L +AA H V ++L+ AGA T N AG T + A
Sbjct: 191 RLLLTAFCS--VHEKNQAGD-TALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETA 247
Query: 1173 AEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVP 1222
H + V ++ +S+ G TP A + E E LS P
Sbjct: 248 RYHNNPEVALLLTKAPQGSVSA---GDTPSSEQAVARKEEAREEFLSASP 294
Score = 107 bits (256), Expect = 6e-22
Identities = 73/246 (29%), Positives = 115/246 (46%), Gaps = 5/246 (2%)
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
L NK + ++GRT LHLAA G+ +V+ L++ +DV QT LH A G
Sbjct: 29 LINKGARVAVTKHGRTPLHLAANKGHLPVVQILLKA-GCDLDVQDDGDQTALHRATVVGN 87
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAH 1101
E+ L+ G +D D+ G +H A+ + +S+ +L ++ N V+A K GNT H
Sbjct: 88 TEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLIKAGAN-VLAKNKAGNTALH 146
Query: 1102 IAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDE 1161
+A + L+ + +N D T L +AA H ++R+L+ A S ++
Sbjct: 147 LACQNSHSQSTRVLLLAGSRADL--KNNAGD-TCLHVAARYNHLSIIRLLLTAFCSVHEK 203
Query: 1162 NRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
N+AG TA+H+AA H V ++ G TPL A Y+ E L
Sbjct: 204 NQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAP 263
Query: 1222 PGTVKS 1227
G+V +
Sbjct: 264 QGSVSA 269
Score = 93.9 bits (223), Expect = 6e-18
Identities = 67/228 (29%), Positives = 114/228 (50%), Gaps = 9/228 (3%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G TPL +A ++GH+ +V LL +DV D ++ALH A G ++ AL+ +
Sbjct: 42 GRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCAL 101
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKK--QTPLHLAAASGQIEVCK 1046
+ + ++G TALH A+ +G++ K LI+ A +VL K T LHLA + + +
Sbjct: 102 DRQDKDGNTALHEASWHGFSQSAKLLIK---AGANVLAKNKAGNTALHLACQNSHSQSTR 158
Query: 1047 LLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQ 1106
+LL G+ D + G +H AA+ N+ +++L L + V + G+T H+AA
Sbjct: 159 VLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCS-VHEKNQAGDTALHVAAAL 217
Query: 1107 GSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRA 1154
KV + L++ G + TPL+ A + +V +L +A
Sbjct: 218 NHKKVAKILLE---AGADTTIVNNAGQTPLETARYHNNPEVALLLTKA 262
Score = 83.0 bits (196), Expect = 1e-14
Identities = 80/299 (26%), Positives = 134/299 (44%), Gaps = 22/299 (7%)
Query: 1171 LAAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEA 1229
+AA G T NV+ ++ R++ K G TPLH+AA G V+ LL
Sbjct: 16 VAAYKGQTENVVQLINKG--ARVAVTKHGRTPLHLAANKGHLPVVQILLK---------- 63
Query: 1230 PTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFG 1289
G L + + T LH A GN ++ L++ G D +++G LH A +
Sbjct: 64 -AGCDLD--VQDDGDQTALHRATVVGNTEIIAALIHE-GCALDR-QDKDGNTALHEASWH 118
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP 1349
G LL+ A +L + ++ G T LH+A + H Q VLL G+ + + G T
Sbjct: 119 GFSQSAKLLIKAGANVL-AKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTC 177
Query: 1350 LHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLM 1409
LH AA+ HL++++LL + S + + AA+ NH V + LL DT +
Sbjct: 178 LHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVN 237
Query: 1410 DDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKERAKDLIAA 1468
+ + + ++ HNN + + +P +A + ++ KE+ R + L A+
Sbjct: 238 NAGQ---TPLETARYHNNPEVALLLTKAPQGSVSAGDTPSSEQAVARKEEAREEFLSAS 293
Score = 71.3 bits (167), Expect = 3e-11
Identities = 47/152 (30%), Positives = 71/152 (46%), Gaps = 3/152 (1%)
Query: 70 AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNG 129
A GN ++ L+ A L G+TALH A+ A++L+ GA V A N
Sbjct: 82 ATVVGNTEIIAALIHEGCA--LDRQDKDGNTALHEASWHGFSQSAKLLIKAGANVLAKNK 139
Query: 130 AGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKA 189
AG T LH+A + + A + +N T +H+AA H +II LL F
Sbjct: 140 AGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAF-C 198
Query: 190 SIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
S+ E+ + G T +H+A+ H A +L + G
Sbjct: 199 SVHEKNQAGDTALHVAAALNHKKVAKILLEAG 230
Score = 67.7 bits (158), Expect = 4e-10
Identities = 60/209 (28%), Positives = 93/209 (44%), Gaps = 17/209 (8%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+D D+ +ALH A V E+ + LI G + Q + + TA H +
Sbjct: 68 LDVQDDGDQTALHRATVVGNTEI---------IAALIHEGCALDRQDKDGN-TALHEASW 117
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
G + +I + A+V +N G T L +AC H Q LL +R D+ +
Sbjct: 118 HGFSQSAKLLIK--AGANVLA----KNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKN 171
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
G + LH+AA + +L + LLT ++ K + G TALH+AA + + K L+ +
Sbjct: 172 NAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILL-EAG 230
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
A ++ QTPL A EV LL
Sbjct: 231 ADTTIVNNAGQTPLETARYHNNPEVALLL 259
Score = 62.9 bits (146), Expect = 1e-08
Identities = 41/129 (31%), Positives = 61/129 (47%), Gaps = 2/129 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L LA + + R LL A + LK AGDT LH+AAR + + R+L+
Sbjct: 141 GNTALHLACQNSHSQSTRVLLLAGSRADLKNN--AGDTCLHVAARYNHLSIIRLLLTAFC 198
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V N AG T LH+AAA + + K A+ I +N +TP+ A + + + L
Sbjct: 199 SVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALL 258
Query: 183 LADKFKASI 191
L + S+
Sbjct: 259 LTKAPQGSV 267
Score = 61.3 bits (142), Expect = 4e-08
Identities = 47/175 (26%), Positives = 72/175 (41%), Gaps = 5/175 (2%)
Query: 56 RDLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMAR 115
R V + G+ PL LA G+ +V+ LL A L TALH A + ++
Sbjct: 35 RVAVTKHGRTPLHLAANKGHLPVVQILLKAGC--DLDVQDDGDQTALHRATVVGNTEIIA 92
Query: 116 ILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENG 175
L+ G +D + G T LH A+ G K AN + T +HLA +N
Sbjct: 93 ALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLIKAGANVLAKNKAGNTALHLACQNS 152
Query: 176 HAAIIE-LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
H+ LL +A + + G T +H+A+ H +L +H N+
Sbjct: 153 HSQSTRVLLLAGSRADL--KNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQ 205
Score = 56.0 bits (129), Expect = 1e-06
Identities = 60/231 (25%), Positives = 98/231 (42%), Gaps = 25/231 (10%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA GH+ ++ LL+ G +DV + + TALH A ++ L+ G +
Sbjct: 42 GRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCAL 101
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFG-NLATLV 781
R K T LH A + A +L+K+GA + G T +H+A + + +T V
Sbjct: 102 D-RQDKDGNTALH-EASWHGFSQSAKLLIKAGANVLAKNKAGNTALHLACQNSHSQSTRV 159
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF-- 839
LLL L+ G+T L +A R I+R L+ TAF
Sbjct: 160 LLLAGSRADLKNN--------AGDTCLHVAARYNHLSIIRLLL------------TAFCS 199
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNH 890
+ ++ G +ALH A + ++V + ++ N L+T H
Sbjct: 200 VHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYH 250
Score = 52.8 bits (121), Expect = 1e-05
Identities = 36/125 (28%), Positives = 56/125 (44%), Gaps = 2/125 (1%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ G ++H A + H LL G D+ N T LH+A +++ LL
Sbjct: 137 KNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTA 196
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
VH + + +T LH+AA + + K A +LL++GA G TP+ A N
Sbjct: 197 FCSVHEK-NQAGDTALHVAAAL-NHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPE 254
Query: 779 TLVLL 783
+LL
Sbjct: 255 VALLL 259
Score = 52.0 bits (119), Expect = 2e-05
Identities = 45/155 (29%), Positives = 71/155 (45%), Gaps = 10/155 (6%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA G + L+ KG V VT + T LH+A VV+ LL G D+ ++
Sbjct: 17 AAYKGQTENVVQLINKGARVAVTKHGR-TPLHLAANKGHLPVVQILLKAGCDLDVQDDGD 75
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
+T LH A + + + A L+ G ++ +DG T +H A+ G + LL++ G +
Sbjct: 76 -QTALHRATVVGNTEIIA-ALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLIKAGAN 133
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLI 824
L K K G T L +AC++ R L+
Sbjct: 134 VLAKNK-------AGNTALHLACQNSHSQSTRVLL 161
Score = 50.0 bits (114), Expect = 9e-05
Identities = 40/115 (34%), Positives = 52/115 (45%), Gaps = 2/115 (1%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ G +H AARY H+ II LL SV TALH+A V + LL
Sbjct: 170 KNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEA 229
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK 773
GAD I +TPL AR + + AL+L K+ G A + + VA K
Sbjct: 230 GADTTI-VNNAGQTPLE-TARYHNNPEVALLLTKAPQGSVSAGDTPSSEQAVARK 282
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/128 (27%), Positives = 59/128 (46%), Gaps = 2/128 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DG ++H A+ +G L++ G +V TALH+A ++ LL G+
Sbjct: 107 DGNTALHEASWHGFSQSAKLLIKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSR 166
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
++ +T LH+AAR + +LL + ++ + G T +HVAA +
Sbjct: 167 ADLK-NNAGDTCLHVAARY-NHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAK 224
Query: 782 LLLEDGGD 789
+LLE G D
Sbjct: 225 ILLEAGAD 232
>AL096678-2|CAI42280.1| 692|Homo sapiens ankyrin repeat domain 6
protein.
Length = 692
Score = 114 bits (274), Expect = 4e-24
Identities = 88/290 (30%), Positives = 138/290 (47%), Gaps = 9/290 (3%)
Query: 933 LLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKA 992
LL+A ++G + V L+ ARV V GR+ LHLAA G+L V LL ++ +
Sbjct: 14 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
Query: 993 RNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELG 1052
+TALH A + G ++ LI + +D T LH A+ G + KLL++ G
Sbjct: 73 DGDQTALHRATVVGNTEIIAALIHE-GCALDRQDKDGNTALHEASWHGFSQSAKLLIKAG 131
Query: 1053 ANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVI 1112
AN+ A ++ G +H A QN++S+ ++ L + G+TC H+AA + +I
Sbjct: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNA-GDTCLHVAARYNHLSII 190
Query: 1113 EELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA 1172
L+ + + +N+ D T L +AA H V ++L+ AGA T N AG T + A
Sbjct: 191 RLLLTAFCS--VHEKNQAGD-TALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETA 247
Query: 1173 AEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVP 1222
H + V ++ +S+ G TP A + E E LS P
Sbjct: 248 RYHNNPEVALLLTKAPQGSVSA---GDTPSSEQAVARKEEAREEFLSASP 294
Score = 107 bits (256), Expect = 6e-22
Identities = 73/246 (29%), Positives = 115/246 (46%), Gaps = 5/246 (2%)
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
L NK + ++GRT LHLAA G+ +V+ L++ +DV QT LH A G
Sbjct: 29 LINKGARVAVTKHGRTPLHLAANKGHLPVVQILLKA-GCDLDVQDDGDQTALHRATVVGN 87
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAH 1101
E+ L+ G +D D+ G +H A+ + +S+ +L ++ N V+A K GNT H
Sbjct: 88 TEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLIKAGAN-VLAKNKAGNTALH 146
Query: 1102 IAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDE 1161
+A + L+ + +N D T L +AA H ++R+L+ A S ++
Sbjct: 147 LACQNSHSQSTRVLLLAGSRADL--KNNAGD-TCLHVAARYNHLSIIRLLLTAFCSVHEK 203
Query: 1162 NRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
N+AG TA+H+AA H V ++ G TPL A Y+ E L
Sbjct: 204 NQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAP 263
Query: 1222 PGTVKS 1227
G+V +
Sbjct: 264 QGSVSA 269
Score = 93.9 bits (223), Expect = 6e-18
Identities = 67/228 (29%), Positives = 114/228 (50%), Gaps = 9/228 (3%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G TPL +A ++GH+ +V LL +DV D ++ALH A G ++ AL+ +
Sbjct: 42 GRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCAL 101
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKK--QTPLHLAAASGQIEVCK 1046
+ + ++G TALH A+ +G++ K LI+ A +VL K T LHLA + + +
Sbjct: 102 DRQDKDGNTALHEASWHGFSQSAKLLIK---AGANVLAKNKAGNTALHLACQNSHSQSTR 158
Query: 1047 LLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQ 1106
+LL G+ D + G +H AA+ N+ +++L L + V + G+T H+AA
Sbjct: 159 VLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCS-VHEKNQAGDTALHVAAAL 217
Query: 1107 GSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRA 1154
KV + L++ G + TPL+ A + +V +L +A
Sbjct: 218 NHKKVAKILLE---AGADTTIVNNAGQTPLETARYHNNPEVALLLTKA 262
Score = 83.0 bits (196), Expect = 1e-14
Identities = 80/299 (26%), Positives = 134/299 (44%), Gaps = 22/299 (7%)
Query: 1171 LAAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEA 1229
+AA G T NV+ ++ R++ K G TPLH+AA G V+ LL
Sbjct: 16 VAAYKGQTENVVQLINKG--ARVAVTKHGRTPLHLAANKGHLPVVQILLK---------- 63
Query: 1230 PTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFG 1289
G L + + T LH A GN ++ L++ G D +++G LH A +
Sbjct: 64 -AGCDLD--VQDDGDQTALHRATVVGNTEIIAALIHE-GCALDR-QDKDGNTALHEASWH 118
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP 1349
G LL+ A +L + ++ G T LH+A + H Q VLL G+ + + G T
Sbjct: 119 GFSQSAKLLIKAGANVL-AKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTC 177
Query: 1350 LHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLM 1409
LH AA+ HL++++LL + S + + AA+ NH V + LL DT +
Sbjct: 178 LHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVN 237
Query: 1410 DDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKERAKDLIAA 1468
+ + + ++ HNN + + +P +A + ++ KE+ R + L A+
Sbjct: 238 NAGQ---TPLETARYHNNPEVALLLTKAPQGSVSAGDTPSSEQAVARKEEAREEFLSAS 293
Score = 71.3 bits (167), Expect = 3e-11
Identities = 47/152 (30%), Positives = 71/152 (46%), Gaps = 3/152 (1%)
Query: 70 AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNG 129
A GN ++ L+ A L G+TALH A+ A++L+ GA V A N
Sbjct: 82 ATVVGNTEIIAALIHEGCA--LDRQDKDGNTALHEASWHGFSQSAKLLIKAGANVLAKNK 139
Query: 130 AGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKA 189
AG T LH+A + + A + +N T +H+AA H +II LL F
Sbjct: 140 AGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAF-C 198
Query: 190 SIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
S+ E+ + G T +H+A+ H A +L + G
Sbjct: 199 SVHEKNQAGDTALHVAAALNHKKVAKILLEAG 230
Score = 67.7 bits (158), Expect = 4e-10
Identities = 60/209 (28%), Positives = 93/209 (44%), Gaps = 17/209 (8%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+D D+ +ALH A V E+ + LI G + Q + + TA H +
Sbjct: 68 LDVQDDGDQTALHRATVVGNTEI---------IAALIHEGCALDRQDKDGN-TALHEASW 117
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
G + +I + A+V +N G T L +AC H Q LL +R D+ +
Sbjct: 118 HGFSQSAKLLIK--AGANVLA----KNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKN 171
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
G + LH+AA + +L + LLT ++ K + G TALH+AA + + K L+ +
Sbjct: 172 NAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILL-EAG 230
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
A ++ QTPL A EV LL
Sbjct: 231 ADTTIVNNAGQTPLETARYHNNPEVALLL 259
Score = 62.9 bits (146), Expect = 1e-08
Identities = 41/129 (31%), Positives = 61/129 (47%), Gaps = 2/129 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L LA + + R LL A + LK AGDT LH+AAR + + R+L+
Sbjct: 141 GNTALHLACQNSHSQSTRVLLLAGSRADLKNN--AGDTCLHVAARYNHLSIIRLLLTAFC 198
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V N AG T LH+AAA + + K A+ I +N +TP+ A + + + L
Sbjct: 199 SVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALL 258
Query: 183 LADKFKASI 191
L + S+
Sbjct: 259 LTKAPQGSV 267
Score = 61.3 bits (142), Expect = 4e-08
Identities = 47/175 (26%), Positives = 72/175 (41%), Gaps = 5/175 (2%)
Query: 56 RDLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMAR 115
R V + G+ PL LA G+ +V+ LL A L TALH A + ++
Sbjct: 35 RVAVTKHGRTPLHLAANKGHLPVVQILLKAGC--DLDVQDDGDQTALHRATVVGNTEIIA 92
Query: 116 ILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENG 175
L+ G +D + G T LH A+ G K AN + T +HLA +N
Sbjct: 93 ALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLIKAGANVLAKNKAGNTALHLACQNS 152
Query: 176 HAAIIE-LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
H+ LL +A + + G T +H+A+ H +L +H N+
Sbjct: 153 HSQSTRVLLLAGSRADL--KNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQ 205
Score = 56.0 bits (129), Expect = 1e-06
Identities = 60/231 (25%), Positives = 98/231 (42%), Gaps = 25/231 (10%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA GH+ ++ LL+ G +DV + + TALH A ++ L+ G +
Sbjct: 42 GRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCAL 101
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFG-NLATLV 781
R K T LH A + A +L+K+GA + G T +H+A + + +T V
Sbjct: 102 D-RQDKDGNTALH-EASWHGFSQSAKLLIKAGANVLAKNKAGNTALHLACQNSHSQSTRV 159
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF-- 839
LLL L+ G+T L +A R I+R L+ TAF
Sbjct: 160 LLLAGSRADLKNN--------AGDTCLHVAARYNHLSIIRLLL------------TAFCS 199
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNH 890
+ ++ G +ALH A + ++V + ++ N L+T H
Sbjct: 200 VHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYH 250
Score = 52.8 bits (121), Expect = 1e-05
Identities = 36/125 (28%), Positives = 56/125 (44%), Gaps = 2/125 (1%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ G ++H A + H LL G D+ N T LH+A +++ LL
Sbjct: 137 KNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTA 196
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
VH + + +T LH+AA + + K A +LL++GA G TP+ A N
Sbjct: 197 FCSVHEK-NQAGDTALHVAAAL-NHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPE 254
Query: 779 TLVLL 783
+LL
Sbjct: 255 VALLL 259
Score = 52.0 bits (119), Expect = 2e-05
Identities = 45/155 (29%), Positives = 71/155 (45%), Gaps = 10/155 (6%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA G + L+ KG V VT + T LH+A VV+ LL G D+ ++
Sbjct: 17 AAYKGQTENVVQLINKGARVAVTKHGR-TPLHLAANKGHLPVVQILLKAGCDLDVQDDGD 75
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
+T LH A + + + A L+ G ++ +DG T +H A+ G + LL++ G +
Sbjct: 76 -QTALHRATVVGNTEIIA-ALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLIKAGAN 133
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLI 824
L K K G T L +AC++ R L+
Sbjct: 134 VLAKNK-------AGNTALHLACQNSHSQSTRVLL 161
Score = 50.0 bits (114), Expect = 9e-05
Identities = 40/115 (34%), Positives = 52/115 (45%), Gaps = 2/115 (1%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ G +H AARY H+ II LL SV TALH+A V + LL
Sbjct: 170 KNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEA 229
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK 773
GAD I +TPL AR + + AL+L K+ G A + + VA K
Sbjct: 230 GADTTI-VNNAGQTPLE-TARYHNNPEVALLLTKAPQGSVSAGDTPSSEQAVARK 282
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/128 (27%), Positives = 59/128 (46%), Gaps = 2/128 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DG ++H A+ +G L++ G +V TALH+A ++ LL G+
Sbjct: 107 DGNTALHEASWHGFSQSAKLLIKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSR 166
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
++ +T LH+AAR + +LL + ++ + G T +HVAA +
Sbjct: 167 ADLK-NNAGDTCLHVAARY-NHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAK 224
Query: 782 LLLEDGGD 789
+LLE G D
Sbjct: 225 ILLEAGAD 232
>AB023174-1|BAA76801.2| 693|Homo sapiens KIAA0957 protein protein.
Length = 693
Score = 113 bits (273), Expect = 5e-24
Identities = 88/290 (30%), Positives = 138/290 (47%), Gaps = 9/290 (3%)
Query: 933 LLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKA 992
LL+A ++G + V L+ ARV V GR+ LHLAA G+L V LL ++ +
Sbjct: 15 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 73
Query: 993 RNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELG 1052
+TALH A + G ++ LI + +D T LH A+ G + KLL++ G
Sbjct: 74 DGDQTALHRATVVGNTEIIAALIHE-GCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 132
Query: 1053 ANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVI 1112
AN+ A ++ G +H A QN++S+ ++ L + G+TC H+AA + +I
Sbjct: 133 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNA-GDTCLHVAARYNHLSII 191
Query: 1113 EELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA 1172
L+ + + +N+ D T L +AA H V ++L+ AGA T N AG T + A
Sbjct: 192 RLLLTAFCS--VHEKNQAGD-TALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETA 248
Query: 1173 AEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVP 1222
H + V ++ +S+ G TP A + E E LS P
Sbjct: 249 RYHNNPEVALLLTKAPQGSVSA---GDTPSSEQAVARKEEAREEFLSASP 295
Score = 106 bits (255), Expect = 7e-22
Identities = 73/246 (29%), Positives = 115/246 (46%), Gaps = 5/246 (2%)
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
L NK + ++GRT LHLAA G+ +V+ L++ +DV QT LH A G
Sbjct: 30 LINKGARVAVTKHGRTPLHLAANKGHLPVVQILLKA-GCDLDVQDDGDQTALHRATVVGN 88
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAH 1101
E+ L+ G +D D+ G +H A+ + +S+ +L ++ N V+A K GNT H
Sbjct: 89 TEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGAN-VLAKNKAGNTALH 147
Query: 1102 IAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDE 1161
+A + L+ + +N D T L +AA H ++R+L+ A S ++
Sbjct: 148 LACQNSHSQSTRVLLLAGSRADL--KNNAGD-TCLHVAARYNHLSIIRLLLTAFCSVHEK 204
Query: 1162 NRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
N+AG TA+H+AA H V ++ G TPL A Y+ E L
Sbjct: 205 NQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAP 264
Query: 1222 PGTVKS 1227
G+V +
Sbjct: 265 QGSVSA 270
Score = 93.5 bits (222), Expect = 7e-18
Identities = 66/228 (28%), Positives = 114/228 (50%), Gaps = 9/228 (3%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G TPL +A ++GH+ +V LL +DV D ++ALH A G ++ AL+ +
Sbjct: 43 GRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCAL 102
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKK--QTPLHLAAASGQIEVCK 1046
+ + ++G TALH A+ +G++ K L++ A +VL K T LHLA + + +
Sbjct: 103 DRQDKDGNTALHEASWHGFSQSAKLLVK---AGANVLAKNKAGNTALHLACQNSHSQSTR 159
Query: 1047 LLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQ 1106
+LL G+ D + G +H AA+ N+ +++L L + V + G+T H+AA
Sbjct: 160 VLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCS-VHEKNQAGDTALHVAAAL 218
Query: 1107 GSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRA 1154
KV + L++ G + TPL+ A + +V +L +A
Sbjct: 219 NHKKVAKILLE---AGADTTIVNNAGQTPLETARYHNNPEVALLLTKA 263
Score = 82.6 bits (195), Expect = 1e-14
Identities = 80/299 (26%), Positives = 134/299 (44%), Gaps = 22/299 (7%)
Query: 1171 LAAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEA 1229
+AA G T NV+ ++ R++ K G TPLH+AA G V+ LL
Sbjct: 17 VAAYKGQTENVVQLINKG--ARVAVTKHGRTPLHLAANKGHLPVVQILLK---------- 64
Query: 1230 PTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFG 1289
G L + + T LH A GN ++ L++ G D +++G LH A +
Sbjct: 65 -AGCDLD--VQDDGDQTALHRATVVGNTEIIAALIHE-GCALDR-QDKDGNTALHEASWH 119
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP 1349
G LL+ A +L + ++ G T LH+A + H Q VLL G+ + + G T
Sbjct: 120 GFSQSAKLLVKAGANVL-AKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTC 178
Query: 1350 LHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLM 1409
LH AA+ HL++++LL + S + + AA+ NH V + LL DT +
Sbjct: 179 LHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVN 238
Query: 1410 DDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKERAKDLIAA 1468
+ + + ++ HNN + + +P +A + ++ KE+ R + L A+
Sbjct: 239 NAGQ---TPLETARYHNNPEVALLLTKAPQGSVSAGDTPSSEQAVARKEEAREEFLSAS 294
Score = 71.7 bits (168), Expect = 3e-11
Identities = 48/152 (31%), Positives = 71/152 (46%), Gaps = 3/152 (1%)
Query: 70 AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNG 129
A GN ++ L+ A L G+TALH A+ A++LV GA V A N
Sbjct: 83 ATVVGNTEIIAALIHEGCA--LDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNK 140
Query: 130 AGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKA 189
AG T LH+A + + A + +N T +H+AA H +II LL F
Sbjct: 141 AGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAF-C 199
Query: 190 SIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
S+ E+ + G T +H+A+ H A +L + G
Sbjct: 200 SVHEKNQAGDTALHVAAALNHKKVAKILLEAG 231
Score = 67.3 bits (157), Expect = 6e-10
Identities = 59/209 (28%), Positives = 93/209 (44%), Gaps = 17/209 (8%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+D D+ +ALH A V E+ + LI G + Q + + TA H +
Sbjct: 69 LDVQDDGDQTALHRATVVGNTEI---------IAALIHEGCALDRQDKDGN-TALHEASW 118
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
G + ++ + A+V +N G T L +AC H Q LL +R D+ +
Sbjct: 119 HGFSQSAKLLVK--AGANVLA----KNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKN 172
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
G + LH+AA + +L + LLT ++ K + G TALH+AA + + K L+ +
Sbjct: 173 NAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILL-EAG 231
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
A ++ QTPL A EV LL
Sbjct: 232 ADTTIVNNAGQTPLETARYHNNPEVALLL 260
Score = 62.9 bits (146), Expect = 1e-08
Identities = 41/129 (31%), Positives = 61/129 (47%), Gaps = 2/129 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L LA + + R LL A + LK AGDT LH+AAR + + R+L+
Sbjct: 142 GNTALHLACQNSHSQSTRVLLLAGSRADLKNN--AGDTCLHVAARYNHLSIIRLLLTAFC 199
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V N AG T LH+AAA + + K A+ I +N +TP+ A + + + L
Sbjct: 200 SVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALL 259
Query: 183 LADKFKASI 191
L + S+
Sbjct: 260 LTKAPQGSV 268
Score = 61.3 bits (142), Expect = 4e-08
Identities = 47/175 (26%), Positives = 72/175 (41%), Gaps = 5/175 (2%)
Query: 56 RDLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMAR 115
R V + G+ PL LA G+ +V+ LL A L TALH A + ++
Sbjct: 36 RVAVTKHGRTPLHLAANKGHLPVVQILLKAGC--DLDVQDDGDQTALHRATVVGNTEIIA 93
Query: 116 ILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENG 175
L+ G +D + G T LH A+ G K AN + T +HLA +N
Sbjct: 94 ALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNS 153
Query: 176 HAAIIE-LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
H+ LL +A + + G T +H+A+ H +L +H N+
Sbjct: 154 HSQSTRVLLLAGSRADL--KNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQ 206
Score = 55.6 bits (128), Expect = 2e-06
Identities = 60/231 (25%), Positives = 98/231 (42%), Gaps = 25/231 (10%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA GH+ ++ LL+ G +DV + + TALH A ++ L+ G +
Sbjct: 43 GRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCAL 102
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFG-NLATLV 781
R K T LH A + A +L+K+GA + G T +H+A + + +T V
Sbjct: 103 D-RQDKDGNTALH-EASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRV 160
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF-- 839
LLL L+ G+T L +A R I+R L+ TAF
Sbjct: 161 LLLAGSRADLKNN--------AGDTCLHVAARYNHLSIIRLLL------------TAFCS 200
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNH 890
+ ++ G +ALH A + ++V + ++ N L+T H
Sbjct: 201 VHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYH 251
Score = 52.8 bits (121), Expect = 1e-05
Identities = 36/125 (28%), Positives = 56/125 (44%), Gaps = 2/125 (1%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ G ++H A + H LL G D+ N T LH+A +++ LL
Sbjct: 138 KNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTA 197
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
VH + + +T LH+AA + + K A +LL++GA G TP+ A N
Sbjct: 198 FCSVHEK-NQAGDTALHVAAAL-NHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPE 255
Query: 779 TLVLL 783
+LL
Sbjct: 256 VALLL 260
Score = 51.6 bits (118), Expect = 3e-05
Identities = 45/155 (29%), Positives = 71/155 (45%), Gaps = 10/155 (6%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA G + L+ KG V VT + T LH+A VV+ LL G D+ ++
Sbjct: 18 AAYKGQTENVVQLINKGARVAVTKHGR-TPLHLAANKGHLPVVQILLKAGCDLDVQDDGD 76
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
+T LH A + + + A L+ G ++ +DG T +H A+ G + LL++ G +
Sbjct: 77 -QTALHRATVVGNTEIIA-ALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGAN 134
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLI 824
L K K G T L +AC++ R L+
Sbjct: 135 VLAKNK-------AGNTALHLACQNSHSQSTRVLL 162
Score = 50.0 bits (114), Expect = 9e-05
Identities = 40/115 (34%), Positives = 52/115 (45%), Gaps = 2/115 (1%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ G +H AARY H+ II LL SV TALH+A V + LL
Sbjct: 171 KNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEA 230
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK 773
GAD I +TPL AR + + AL+L K+ G A + + VA K
Sbjct: 231 GADTTI-VNNAGQTPLE-TARYHNNPEVALLLTKAPQGSVSAGDTPSSEQAVARK 283
Score = 48.0 bits (109), Expect = 4e-04
Identities = 35/128 (27%), Positives = 59/128 (46%), Gaps = 2/128 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DG ++H A+ +G L++ G +V TALH+A ++ LL G+
Sbjct: 108 DGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSR 167
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
++ +T LH+AAR + +LL + ++ + G T +HVAA +
Sbjct: 168 ADLK-NNAGDTCLHVAARY-NHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAK 225
Query: 782 LLLEDGGD 789
+LLE G D
Sbjct: 226 ILLEAGAD 233
>BC042173-1|AAH42173.1| 722|Homo sapiens ankyrin repeat domain 6
protein.
Length = 722
Score = 113 bits (271), Expect = 8e-24
Identities = 82/262 (31%), Positives = 130/262 (49%), Gaps = 7/262 (2%)
Query: 933 LLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKA 992
LL+A ++G + V L+ ARV V GR+ LHLAA G+L V LL ++ +
Sbjct: 14 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
Query: 993 RNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELG 1052
+TALH A + G ++ LI + +D T LH A+ G + KLL++ G
Sbjct: 73 DGDQTALHRATVVGNTEIIAALIHE-GCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
Query: 1053 ANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVI 1112
AN+ A ++ G +H A QN++S+ ++ L + G+TC H+AA + +I
Sbjct: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNA-GDTCLHVAARYNHLSII 190
Query: 1113 EELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA 1172
L+ + + +N+ D T L +AA H V ++L+ AGA T N AG T + A
Sbjct: 191 RLLLTAFCS--VHEKNQAGD-TALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETA 247
Query: 1173 AEHGHTNV-LDVMRSTNTLRIS 1193
H + V L + ++ LR S
Sbjct: 248 RYHNNPEVALLLTKAPQVLRFS 269
Score = 106 bits (255), Expect = 7e-22
Identities = 74/245 (30%), Positives = 116/245 (47%), Gaps = 6/245 (2%)
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
L NK + ++GRT LHLAA G+ +V+ L++ +DV QT LH A G
Sbjct: 29 LINKGARVAVTKHGRTPLHLAANKGHLPVVQILLK-AGCDLDVQDDGDQTALHRATVVGN 87
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAH 1101
E+ L+ G +D D+ G +H A+ + +S+ +L ++ N V+A K GNT H
Sbjct: 88 TEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGAN-VLAKNKAGNTALH 146
Query: 1102 IAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDE 1161
+A + L+ +N D T L +AA H ++R+L+ A S ++
Sbjct: 147 LACQNSHSQSTRVLLLAGSRA--DLKNNAGD-TCLHVAARYNHLSIIRLLLTAFCSVHEK 203
Query: 1162 NRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
N+AG TA+H+AA H V ++ G TPL A Y+ E V LL+
Sbjct: 204 NQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPE-VALLLTKA 262
Query: 1222 PGTVK 1226
P ++
Sbjct: 263 PQVLR 267
Score = 101 bits (241), Expect = 4e-20
Identities = 78/267 (29%), Positives = 131/267 (49%), Gaps = 20/267 (7%)
Query: 1102 IAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDE 1161
+AA +G + + +L+ ++ + TPL LAA GH VV++L++AG +
Sbjct: 16 VAAYKGQTENVVQLINKGARVAVTKHGR----TPLHLAANKGHLPVVQILLKAGCDLDVQ 71
Query: 1162 NRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
+ TA+H A G+T ++ + K G T LH A+++G +++ + L
Sbjct: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLL---- 127
Query: 1222 PGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYN 1281
VK+ A + ++G T LHLA N + R+LL AG +AD +N G
Sbjct: 128 ---VKAGANV------LAKNKAGNTALHLACQNSHSQSTRVLL-LAGSRADLKNNA-GDT 176
Query: 1282 PLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINA 1341
LH+A H+SI+ LLL+ + H ++ G T LH+A+ H ++ ++LL GA+
Sbjct: 177 CLHVAARYNHLSIIRLLLTAFCSV-HEKNQAGDTALHVAAALNHKKVAKILLEAGADTTI 235
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCES 1368
+ G TPL A + V LL ++
Sbjct: 236 VNNAGQTPLETARYHNNPEVALLLTKA 262
Score = 100 bits (240), Expect = 5e-20
Identities = 82/271 (30%), Positives = 129/271 (47%), Gaps = 19/271 (7%)
Query: 999 LHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDAT 1058
L +AA G V LI + A + V T +TPLHLAA G + V ++LL+ G ++D
Sbjct: 14 LLVAAYKGQTENVVQLI-NKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQ 71
Query: 1059 DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKF 1118
D+ Q +H A +E++ + + L KDGNT H A+ G + + L+K
Sbjct: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQD-KDGNTALHEASWHGFSQSAKLLVKA 130
Query: 1119 DRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHT 1178
+ A+NK + T L LA + H+ RVL+ AG+ +N AG T +H+AA + H
Sbjct: 131 GAN--VLAKNKAGN-TALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHL 187
Query: 1179 NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPV 1238
+++ ++ + + G T LH+AA + + LL EA ++V
Sbjct: 188 SIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILL---------EAGADTTIV-- 236
Query: 1239 LGAESGLTPLHLAAYNGNENVVRLLLNSAGV 1269
+G TPL A Y+ N V LL + V
Sbjct: 237 --NNAGQTPLETARYHNNPEVALLLTKAPQV 265
Score = 93.5 bits (222), Expect = 7e-18
Identities = 66/228 (28%), Positives = 114/228 (50%), Gaps = 9/228 (3%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G TPL +A ++GH+ +V LL +DV D ++ALH A G ++ AL+ +
Sbjct: 42 GRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCAL 101
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKK--QTPLHLAAASGQIEVCK 1046
+ + ++G TALH A+ +G++ K L++ A +VL K T LHLA + + +
Sbjct: 102 DRQDKDGNTALHEASWHGFSQSAKLLVK---AGANVLAKNKAGNTALHLACQNSHSQSTR 158
Query: 1047 LLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQ 1106
+LL G+ D + G +H AA+ N+ +++L L + V + G+T H+AA
Sbjct: 159 VLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCS-VHEKNQAGDTALHVAAAL 217
Query: 1107 GSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRA 1154
KV + L++ G + TPL+ A + +V +L +A
Sbjct: 218 NHKKVAKILLE---AGADTTIVNNAGQTPLETARYHNNPEVALLLTKA 262
Score = 84.2 bits (199), Expect = 4e-15
Identities = 72/262 (27%), Positives = 109/262 (41%), Gaps = 17/262 (6%)
Query: 1133 STPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
S L +AA G + V L+ GA + G T +HLAA GH V+ ++
Sbjct: 11 SERLLVAAYKGQTENVVQLINKGARVA-VTKHGRTPLHLAANKGHLPVVQILLKAGCDLD 69
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
T LH A G E + L+ + + + G T LH A+
Sbjct: 70 VQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQD-------------KDGNTALHEAS 116
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
++G +LL+ AG A N+ G LHLAC H +LL + +
Sbjct: 117 WHGFSQSAKLLVK-AGANV-LAKNKAGNTALHLACQNSHSQSTRVLLLAGSRA-DLKNNA 173
Query: 1313 GKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASP 1372
G T LH+A+ + H ++ +LL ++ ++ G T LH AA H V K+L E+GA
Sbjct: 174 GDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADT 233
Query: 1373 KSETNLNCAPIWFAASENHNDV 1394
N P+ A N+ +V
Sbjct: 234 TIVNNAGQTPLETARYHNNPEV 255
Score = 81.4 bits (192), Expect = 3e-14
Identities = 70/236 (29%), Positives = 108/236 (45%), Gaps = 19/236 (8%)
Query: 1171 LAAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEA 1229
+AA G T NV+ ++ R++ K G TPLH+AA G V+ LL
Sbjct: 16 VAAYKGQTENVVQLINKG--ARVAVTKHGRTPLHLAANKGHLPVVQILLK---------- 63
Query: 1230 PTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFG 1289
G L + + T LH A GN ++ L++ G D +++G LH A +
Sbjct: 64 -AGCDLD--VQDDGDQTALHRATVVGNTEIIAALIHE-GCALDR-QDKDGNTALHEASWH 118
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP 1349
G LL+ A +L + ++ G T LH+A + H Q VLL G+ + + G T
Sbjct: 119 GFSQSAKLLVKAGANVL-AKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTC 177
Query: 1350 LHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
LH AA+ HL++++LL + S + + AA+ NH V + LL DT
Sbjct: 178 LHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADT 233
Score = 71.7 bits (168), Expect = 3e-11
Identities = 48/152 (31%), Positives = 71/152 (46%), Gaps = 3/152 (1%)
Query: 70 AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNG 129
A GN ++ L+ A L G+TALH A+ A++LV GA V A N
Sbjct: 82 ATVVGNTEIIAALIHEGCA--LDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNK 139
Query: 130 AGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKA 189
AG T LH+A + + A + +N T +H+AA H +II LL F
Sbjct: 140 AGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAF-C 198
Query: 190 SIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
S+ E+ + G T +H+A+ H A +L + G
Sbjct: 199 SVHEKNQAGDTALHVAAALNHKKVAKILLEAG 230
Score = 67.3 bits (157), Expect = 6e-10
Identities = 59/209 (28%), Positives = 93/209 (44%), Gaps = 17/209 (8%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+D D+ +ALH A V E+ + LI G + Q + + TA H +
Sbjct: 68 LDVQDDGDQTALHRATVVGNTEI---------IAALIHEGCALDRQDKDGN-TALHEASW 117
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
G + ++ + A+V +N G T L +AC H Q LL +R D+ +
Sbjct: 118 HGFSQSAKLLVK--AGANVLA----KNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKN 171
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
G + LH+AA + +L + LLT ++ K + G TALH+AA + + K L+ +
Sbjct: 172 NAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILL-EAG 230
Query: 1020 AMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
A ++ QTPL A EV LL
Sbjct: 231 ADTTIVNNAGQTPLETARYHNNPEVALLL 259
Score = 62.5 bits (145), Expect = 2e-08
Identities = 42/132 (31%), Positives = 61/132 (46%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L LA + + R LL A + LK AGDT LH+AAR + + R+L+
Sbjct: 141 GNTALHLACQNSHSQSTRVLLLAGSRADLKNN--AGDTCLHVAARYNHLSIIRLLLTAFC 198
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V N AG T LH+AAA + + K A+ I +N +TP+ A + + + L
Sbjct: 199 SVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALL 258
Query: 183 LADKFKASIFER 194
L + F R
Sbjct: 259 LTKAPQVLRFSR 270
Score = 61.3 bits (142), Expect = 4e-08
Identities = 47/175 (26%), Positives = 72/175 (41%), Gaps = 5/175 (2%)
Query: 56 RDLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMAR 115
R V + G+ PL LA G+ +V+ LL A L TALH A + ++
Sbjct: 35 RVAVTKHGRTPLHLAANKGHLPVVQILLKAGC--DLDVQDDGDQTALHRATVVGNTEIIA 92
Query: 116 ILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENG 175
L+ G +D + G T LH A+ G K AN + T +HLA +N
Sbjct: 93 ALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNS 152
Query: 176 HAAIIE-LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
H+ LL +A + + G T +H+A+ H +L +H N+
Sbjct: 153 HSQSTRVLLLAGSRADL--KNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQ 205
Score = 55.6 bits (128), Expect = 2e-06
Identities = 60/231 (25%), Positives = 98/231 (42%), Gaps = 25/231 (10%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA GH+ ++ LL+ G +DV + + TALH A ++ L+ G +
Sbjct: 42 GRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCAL 101
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFG-NLATLV 781
R K T LH A + A +L+K+GA + G T +H+A + + +T V
Sbjct: 102 D-RQDKDGNTALH-EASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRV 159
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF-- 839
LLL L+ G+T L +A R I+R L+ TAF
Sbjct: 160 LLLAGSRADLKNN--------AGDTCLHVAARYNHLSIIRLLL------------TAFCS 199
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNH 890
+ ++ G +ALH A + ++V + ++ N L+T H
Sbjct: 200 VHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYH 250
Score = 54.0 bits (124), Expect = 5e-06
Identities = 39/134 (29%), Positives = 61/134 (45%), Gaps = 3/134 (2%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ G ++H A + H LL G D+ N T LH+A +++ LL
Sbjct: 137 KNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTA 196
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
VH + + +T LH+AA + + K A +LL++GA G TP+ A++ N
Sbjct: 197 FCSVHEK-NQAGDTALHVAAAL-NHKKVAKILLEAGADTTIVNNAGQTPLE-TARYHNNP 253
Query: 779 TLVLLLEDGGDPLR 792
+ LLL LR
Sbjct: 254 EVALLLTKAPQVLR 267
Score = 51.6 bits (118), Expect = 3e-05
Identities = 45/155 (29%), Positives = 71/155 (45%), Gaps = 10/155 (6%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA G + L+ KG V VT + T LH+A VV+ LL G D+ ++
Sbjct: 17 AAYKGQTENVVQLINKGARVAVTKHGR-TPLHLAANKGHLPVVQILLKAGCDLDVQDDGD 75
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
+T LH A + + + A L+ G ++ +DG T +H A+ G + LL++ G +
Sbjct: 76 -QTALHRATVVGNTEIIA-ALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGAN 133
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLI 824
L K K G T L +AC++ R L+
Sbjct: 134 VLAKNK-------AGNTALHLACQNSHSQSTRVLL 161
Score = 48.0 bits (109), Expect = 4e-04
Identities = 35/128 (27%), Positives = 59/128 (46%), Gaps = 2/128 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DG ++H A+ +G L++ G +V TALH+A ++ LL G+
Sbjct: 107 DGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSR 166
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
++ +T LH+AAR + +LL + ++ + G T +HVAA +
Sbjct: 167 ADLK-NNAGDTCLHVAARY-NHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAK 224
Query: 782 LLLEDGGD 789
+LLE G D
Sbjct: 225 ILLEAGAD 232
>BC101275-1|AAI01276.1| 423|Homo sapiens ANKDD1A protein protein.
Length = 423
Score = 111 bits (268), Expect = 2e-23
Identities = 84/276 (30%), Positives = 140/276 (50%), Gaps = 17/276 (6%)
Query: 1093 TKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+KDG T H AA +G V V+ +M+ + +KL T AAE G D + LV
Sbjct: 30 SKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLG-RTAFHRAAEHGQLDALDFLV 88
Query: 1153 RAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAE 1212
+G +++ G TA+HLAA GH VL + GLT LH AA +
Sbjct: 89 GSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPD 148
Query: 1213 TVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
V +LL TV + + L+ LH AA +G+E+V R+L+++ G A+
Sbjct: 149 CV-QLLLRAGSTVNALT------------QKNLSCLHYAALSGSEDVSRVLIHAGGC-AN 194
Query: 1273 AASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVL 1332
++ G +PLHLA ++V LL++ +++ ++ D +T LH+A+ H + ++L
Sbjct: 195 VVDHQ-GASPLHLAVRHNFPALVRLLINSDSDV-NAVDNRQQTPLHLAAEHAWQDIADML 252
Query: 1333 LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCES 1368
L G ++N DK G T L A ++ H+++V ++ ++
Sbjct: 253 LIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKA 288
Score = 105 bits (251), Expect = 2e-21
Identities = 77/278 (27%), Positives = 137/278 (49%), Gaps = 13/278 (4%)
Query: 933 LLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTN--KAFINS 990
LL++ GH++++ L+ + A++ +G + LH AA+ G++ V ++ + ++
Sbjct: 4 LLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDH 63
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIR---DHNAMIDVLTLKKQTPLHLAAASGQIEVCKL 1047
+ GRTA H AA +G + FL+ DHN V + T LHLAA G + V +
Sbjct: 64 VDKLGRTAFHRAAEHGQLDALDFLVGSGCDHN----VKDKEGNTALHLAAGRGHMAVLQR 119
Query: 1048 LLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQG 1107
L+++G +++ + G +H+AA ++ + VQL L+ + V A T+ +C H AA+ G
Sbjct: 120 LVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRA-GSTVNALTQKNLSCLHYAALSG 178
Query: 1108 SVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLT 1167
S V L+ G + ++PL LA +VR+L+ + + + T
Sbjct: 179 SEDVSRVLI---HAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQT 235
Query: 1168 AVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIA 1205
+HLAAEH ++ D++ K G T L +A
Sbjct: 236 PLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVA 273
Score = 103 bits (247), Expect = 7e-21
Identities = 88/303 (29%), Positives = 142/303 (46%), Gaps = 22/303 (7%)
Query: 1033 LHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA- 1091
L L+A G + + ++L+ GA I + G +H AAQ + V+ ++ ++ +
Sbjct: 4 LLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDH 63
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
K G T H AA G + ++ L+ +G +T L LAA GH V++ L
Sbjct: 64 VDKLGRTAFHRAAEHGQLDALDFLVG---SGCDHNVKDKEGNTALHLAAGRGHMAVLQRL 120
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLD-VMRSTNTLRISSKKLGLTPLHIAAYYGQ 1210
V G ++N GLTA+H AA H + + ++R+ +T+ ++K L+ LH AA G
Sbjct: 121 VDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQK-NLSCLHYAALSG- 178
Query: 1211 AETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQ 1270
+E V +L H G + G +PLHLA + +VRLL+NS
Sbjct: 179 SEDVSRVLIHAGGCAN------------VVDHQGASPLHLAVRHNFPALVRLLINSDS-D 225
Query: 1271 ADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVE 1330
+A N PLHLA I +LL + L+ D+ GKT L +A H +V+
Sbjct: 226 VNAVDNRQ-QTPLHLAAEHAWQDIADMLLIAGVD-LNLRDKQGKTALAVAVRSNHVSLVD 283
Query: 1331 VLL 1333
+++
Sbjct: 284 MII 286
Score = 101 bits (241), Expect = 4e-20
Identities = 77/286 (26%), Positives = 140/286 (48%), Gaps = 12/286 (4%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
++++ L+ +GA + +++ T H A G+ V+ ++ + DV AL+ + +G
Sbjct: 14 RILQILVNSGAKIHCESKDGL-TLLHCAAQKGHVPVLAFIMEDLE--DV--ALDHVDKLG 68
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
T A G + ++ L+ + +V D EG +ALHLAA G++ V L+ +
Sbjct: 69 RTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLE 128
Query: 990 SKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL 1049
+ G TALH AA + V+ L+R + ++ LT K + LH AA SG +V ++L+
Sbjct: 129 EQNAEGLTALHSAAGGSHPDCVQLLLRA-GSTVNALTQKNLSCLHYAALSGSEDVSRVLI 187
Query: 1050 ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSV 1109
G + D G P+H A ++N+ +V+L + + V A T H+AA
Sbjct: 188 HAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSD-VNAVDNRQQTPLHLAAEHAWQ 246
Query: 1110 KVIEELMKFDRTGV-ISARNKLNDSTPLQLAAEGGHADVVRVLVRA 1154
+ + L+ GV ++ R+K T L +A H +V ++++A
Sbjct: 247 DIADMLL---IAGVDLNLRDK-QGKTALAVAVRSNHVSLVDMIIKA 288
Score = 99 bits (238), Expect = 8e-20
Identities = 82/267 (30%), Positives = 125/267 (46%), Gaps = 20/267 (7%)
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLD-VMRSTNTLRISS 1194
L L+A GH ++++LV +GA E++ GLT +H AA+ GH VL +M + +
Sbjct: 4 LLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDH 63
Query: 1195 -KKLGLTPLHIAAYYGQAETVRELL-SHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
KLG T H AA +GQ + + L+ S VK + G T LHLAA
Sbjct: 64 VDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDK--------------EGNTALHLAA 109
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
G+ V++ L++ G+ + N G LH A G H V LLL R+ +++ +
Sbjct: 110 GRGHMAVLQRLVD-IGLDLEE-QNAEGLTALHSAAGGSHPDCVQLLL-RAGSTVNALTQK 166
Query: 1313 GKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASP 1372
+ LH A+ G + VL+ G N D G +PLH A + +V+LL S +
Sbjct: 167 NLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDV 226
Query: 1373 KSETNLNCAPIWFAASENHNDVLEYLL 1399
+ N P+ AA D+ + LL
Sbjct: 227 NAVDNRQQTPLHLAAEHAWQDIADMLL 253
Score = 93.1 bits (221), Expect = 1e-17
Identities = 69/256 (26%), Positives = 125/256 (48%), Gaps = 5/256 (1%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRD-HNAMI 1022
+AL L+A G+L++ L+ + A I+ ++++G T LH AA G+ ++ F++ D + +
Sbjct: 2 NALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVAL 61
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
D + +T H AA GQ++ L+ G + + D+ G +H AA + V+Q +
Sbjct: 62 DHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLV 121
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
+L +G T H AA ++ L++ T ++A + N S L AA
Sbjct: 122 DIGLDL-EEQNAEGLTALHSAAGGSHPDCVQLLLRAGST--VNALTQKNLSC-LHYAALS 177
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
G DV RVL+ AG + G + +HLA H ++ ++ ++++ + TPL
Sbjct: 178 GSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPL 237
Query: 1203 HIAAYYGQAETVRELL 1218
H+AA + + LL
Sbjct: 238 HLAAEHAWQDIADMLL 253
Score = 79.4 bits (187), Expect = 1e-13
Identities = 46/156 (29%), Positives = 81/156 (51%), Gaps = 3/156 (1%)
Query: 1245 LTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAE 1304
+ L L+A+ G+ ++++L+NS G + S + G LH A GH+ ++ ++ +
Sbjct: 1 MNALLLSAWFGHLRILQILVNS-GAKIHCESKD-GLTLLHCAAQKGHVPVLAFIMEDLED 58
Query: 1305 L-LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVK 1363
+ L D+ G+T H A+ HG ++ L+G G + N DK G T LH AA GH+ V++
Sbjct: 59 VALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQ 118
Query: 1364 LLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
L + G + + + AA +H D ++ LL
Sbjct: 119 RLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLL 154
Score = 76.6 bits (180), Expect = 9e-13
Identities = 60/243 (24%), Positives = 106/243 (43%), Gaps = 14/243 (5%)
Query: 1166 LTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTV 1225
+ A+ L+A GH +L ++ ++ K GLT LH AA G + ++ +
Sbjct: 1 MNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVA 60
Query: 1226 KSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHL 1285
+ G T H AA +G + + L+ S G + E G LHL
Sbjct: 61 LDHVD-----------KLGRTAFHRAAEHGQLDALDFLVGS-GCDHNVKDKE-GNTALHL 107
Query: 1286 ACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKN 1345
A GHM+++ L+ +L + G T LH A+ H V++LL G+ +NA +
Sbjct: 108 AAGRGHMAVLQRLVDIGLDL-EEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQK 166
Query: 1346 GWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
+ LH AA +G +V ++L +G + +P+ A N ++ L++ + D
Sbjct: 167 NLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDV 226
Query: 1406 QSL 1408
++
Sbjct: 227 NAV 229
Score = 73.7 bits (173), Expect = 6e-12
Identities = 79/307 (25%), Positives = 136/307 (44%), Gaps = 35/307 (11%)
Query: 711 VVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLK-SGAGPNKATEDGMTPVH 769
+++ L+ GA +H K T LH AA+ A ++ + + G T H
Sbjct: 15 ILQILVNSGAKIHCES-KDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFH 73
Query: 770 VAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKD 829
AA+ G L L L+ G D K K G T L +A +++ L++ D
Sbjct: 74 RAAEHGQLDALDFLVGSGCDHNVKDK-------EGNTALHLAAGRGHMAVLQRLVDIGLD 126
Query: 830 HKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHN 889
++ + +G +ALH A + + V+ L+ G+ V+ T+ N
Sbjct: 127 ----------LEEQNAEGLTALHSAAGGSHPDC---------VQLLLRAGSTVNALTQKN 167
Query: 890 HETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLL 949
+ HY A++G+ DV +I A+V ++ Q G +PL +A LV L+
Sbjct: 168 L-SCLHYAALSGSEDVSRVLIHAGGCANV---VDHQ---GASPLHLAVRHNFPALVRLLI 220
Query: 950 TNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAH 1009
+ + V+ D ++ LHLAAEH + + D LL +N + + G+TAL +A + +
Sbjct: 221 NSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVS 280
Query: 1010 LVKFLIR 1016
LV +I+
Sbjct: 281 LVDMIIK 287
Score = 69.3 bits (162), Expect = 1e-10
Identities = 46/157 (29%), Positives = 79/157 (50%), Gaps = 5/157 (3%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVD-MARILVDYGAV-V 124
LLL+ G+ +++ L+++ ++ + G T LH AA++ V +A I+ D V +
Sbjct: 4 LLLSAWFGHLRILQILVNS--GAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVAL 61
Query: 125 DATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
D + G+T H AA G + + G + + D E T +HLAA GH A+++ L
Sbjct: 62 DHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLV 121
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
D + E+ +G T +H A+ H DC +L + G
Sbjct: 122 D-IGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAG 157
Score = 67.3 bits (157), Expect = 6e-10
Identities = 79/320 (24%), Positives = 136/320 (42%), Gaps = 37/320 (11%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHI-RGGK 728
+A +GH+ I+ L+ G + + D T LH A + V+ ++ DV + K
Sbjct: 7 SAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDK 66
Query: 729 QRETPLHIAARIPDGDKCAL-MLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
T H AA G AL L+ SG N ++G T +H+AA G++A L L++ G
Sbjct: 67 LGRTAFHRAAE--HGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIG 124
Query: 788 GDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDG 847
D + G T L A PD V+ L+ + + ++A+ +
Sbjct: 125 LDLEEQN-------AEGLTALHSAAGGSHPDCVQLLLR----------AGSTVNALTQKN 167
Query: 848 ASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMT 907
S LHYA E+V + LI G ++ H + H A+ N +
Sbjct: 168 LSCLHYAALSGSEDVS---------RVLIHAGGCANV-VDHQGASPLH-LAVRHNFPALV 216
Query: 908 EMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALH 967
++ + S +DV+ NRQ TPL +A + + LL +++ D +G++AL
Sbjct: 217 RLLIN-SDSDVNAVDNRQQ----TPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALA 271
Query: 968 LAAEHGYLQVCDALLTNKAF 987
+A ++ + D ++ F
Sbjct: 272 VAVRSNHVSLVDMIIKADRF 291
Score = 63.3 bits (147), Expect = 9e-09
Identities = 45/169 (26%), Positives = 79/169 (46%), Gaps = 3/169 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G L LA G+ ++++ L+ L+ G TALH AA D ++L+
Sbjct: 99 KEGNTALHLAAGRGHMAVLQRLVDIGL--DLEEQNAEGLTALHSAAGGSHPDCVQLLLRA 156
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G+ V+A + LH AA G E + + A + D++ +P+HLA + A++
Sbjct: 157 GSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALV 216
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
LL + + + T +H+A+ + D A ML GV L++ +K
Sbjct: 217 RLLINS-DSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDK 264
Score = 62.9 bits (146), Expect = 1e-08
Identities = 43/157 (27%), Positives = 69/157 (43%), Gaps = 3/157 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + V+ LL A + + A T + LH AA D++R+L+ G
Sbjct: 134 GLTALHSAAGGSHPDCVQLLLRAGST--VNALTQKNLSCLHYAALSGSEDVSRVLIHAGG 191
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ + G +PLH+A LV+ ++ DN +TP+HLAAE+ I ++
Sbjct: 192 CANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADM 251
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
L + R K G T + +A + H M+ K
Sbjct: 252 LLIA-GVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 287
Score = 60.1 bits (139), Expect = 8e-08
Identities = 56/201 (27%), Positives = 93/201 (46%), Gaps = 21/201 (10%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G + H AA +G + ++ L+ G +V + TALH+A AV++ L+ G D+
Sbjct: 68 GRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDL 127
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + T LH AA D C +LL++G+ N T+ ++ +H AA G+ +
Sbjct: 128 EEQNA-EGLTALHSAAGGSHPD-CVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRV 185
Query: 783 LLEDGGDPLRKTKVCIYDV-VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
L+ GG C V G +PL +A R P +VR LI S + ++
Sbjct: 186 LIHAGG--------CANVVDHQGASPLHLAVRHNFPALVRLLIN----------SDSDVN 227
Query: 842 AVDEDGASALHYACKVTKEEV 862
AVD + LH A + +++
Sbjct: 228 AVDNRQQTPLHLAAEHAWQDI 248
Score = 57.6 bits (133), Expect = 4e-07
Identities = 78/291 (26%), Positives = 126/291 (43%), Gaps = 39/291 (13%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY--TALHIAVESCKPAVVETLLGYG 719
DG +H AA+ GHV ++ +++ E V + D TA H A E + ++ L+G G
Sbjct: 32 DGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSG 91
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALM-LLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
D +++ K+ T LH+AA G L L+ G + +G+T +H AA +
Sbjct: 92 CDHNVK-DKEGNTALHLAA--GRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPD 148
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LLL G T+ + + L A S D+ R LI H G
Sbjct: 149 CVQLLLRAGSTVNALTQKNL-------SCLHYAALSGSEDVSRVLI-----HAG-----G 191
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
+ VD GAS LH A + P +V+ LI + +DV+ + +T H A
Sbjct: 192 CANVVDHQGASPLHLAVR-----HNFPA----LVRLLINSDSDVN-AVDNRQQTPLHLAA 241
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLL 949
D+ ++ I+ D LN ++ G T L +A H+ LV+ ++
Sbjct: 242 EHAWQDIADMLL--IAGVD----LNLRDKQGKTALAVAVRSNHVSLVDMII 286
Score = 55.2 bits (127), Expect = 2e-06
Identities = 36/131 (27%), Positives = 61/131 (46%), Gaps = 2/131 (1%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K +G ++H AA GH+ ++ L+ G ++ + TALH A P V+ LL
Sbjct: 97 KDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRA 156
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
G+ V+ K LH AA + + + +L+ +G N G +P+H+A + A
Sbjct: 157 GSTVNALTQKNLSC-LHYAA-LSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPA 214
Query: 779 TLVLLLEDGGD 789
+ LL+ D
Sbjct: 215 LVRLLINSDSD 225
Score = 50.4 bits (115), Expect = 7e-05
Identities = 38/130 (29%), Positives = 61/130 (46%), Gaps = 3/130 (2%)
Query: 101 ALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI- 159
AL L+A + + +ILV+ GA + + G T LH AA +G P++ + + A+
Sbjct: 3 ALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALD 62
Query: 160 -ADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF 218
D RT H AAE+G ++ L + K+G+T +H+A+ GH L
Sbjct: 63 HVDKLGRTAFHRAAEHGQLDALDFLVGS-GCDHNVKDKEGNTALHLAAGRGHMAVLQRLV 121
Query: 219 KKGVYLHMPN 228
G+ L N
Sbjct: 122 DIGLDLEEQN 131
>AF451977-1|AAL49758.1| 1431|Homo sapiens cask-interacting protein 1
protein.
Length = 1431
Score = 110 bits (264), Expect = 6e-23
Identities = 72/240 (30%), Positives = 121/240 (50%), Gaps = 8/240 (3%)
Query: 983 TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQI 1042
T K +N + +G +ALH AA+NG L+ L+ + A +D+ K PLH AA G+
Sbjct: 37 TKKINVNFQDPDGFSALHHAALNGNTELISLLL-EAQAAVDIKDNKGMRPLHYAAWQGRK 95
Query: 1043 EVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHI 1102
E KL+L+ G+ ++ + G P+H AAQ+ + +V ++ LQ N M G T +
Sbjct: 96 EPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCM-VDNSGKTPLDL 154
Query: 1103 AAIQGSVKVIEELMKFDRTGVI-----SARNKLNDSTPLQLAAEGGHADVVRVLVRAGAS 1157
A G V V++ L+ + + N ++PL LAA+ GH D++R+L++AG
Sbjct: 155 ACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGID 214
Query: 1158 CTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVREL 1217
+ ++G TA+H AA G T V+ ++ + T L I + ++ RE+
Sbjct: 215 INRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREI 273
Score = 98.3 bits (234), Expect = 3e-19
Identities = 74/213 (34%), Positives = 117/213 (54%), Gaps = 25/213 (11%)
Query: 1165 GLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGT 1224
G +A+H AA +G+T ++ ++ G+ PLH AA+ G+ E ++ +L
Sbjct: 49 GFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVL------ 102
Query: 1225 VKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNEN-GYNPL 1283
+A + V+ +P ++ G PLHLAA +G+ +V +LL Q++ +N G PL
Sbjct: 103 ---KAGSAVN-IP---SDEGHIPLHLAAQHGHYDVSEMLLQH---QSNPCMVDNSGKTPL 152
Query: 1284 HLACFGGHMSIVGLLLSRS--AELLH-----STDRHGKTGLHIASTHGHYQMVEVLLGQG 1336
LAC G + +V LLLS + A LL +TD +G + LH+A+ +GH ++ +LL G
Sbjct: 153 DLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAG 212
Query: 1337 AEINATDKNGWTPLHCAAKAGHLNVVKLLCESG 1369
+IN K+G T LH AA G VV+LL +SG
Sbjct: 213 IDINRQTKSG-TALHEAALCGKTEVVRLLLDSG 244
Score = 87.8 bits (208), Expect = 4e-16
Identities = 64/203 (31%), Positives = 107/203 (52%), Gaps = 11/203 (5%)
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
+N Q+ G++ L A G+ +L++ LL A VD+ D +G LH AA G + +
Sbjct: 42 VNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLV 101
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
L + +N + G LHLAA +G+ + + L++ H + ++ +TPL LA G+
Sbjct: 102 LKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQ-HQSNPCMVDNSGKTPLDLACEFGR 160
Query: 1042 IEVCKLLL--ELGANI------DATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT 1093
+ V +LLL + A + DATD G P+H AA+N + ++++L LQ + + T
Sbjct: 161 VGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGID-INRQT 219
Query: 1094 KDGNTCAHIAAIQGSVKVIEELM 1116
K G T H AA+ G +V+ L+
Sbjct: 220 KSG-TALHEAALCGKTEVVRLLL 241
Score = 86.2 bits (204), Expect = 1e-15
Identities = 67/229 (29%), Positives = 109/229 (47%), Gaps = 12/229 (5%)
Query: 950 TNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAH 1009
T V+ D +G SALH AA +G ++ LL +A ++ K G LH AA G
Sbjct: 37 TKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKE 96
Query: 1010 LVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA 1069
+K +++ +A +++ + + PLHLAA G +V ++LL+ +N D G+ P+ A
Sbjct: 97 PMKLVLKAGSA-VNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLA 155
Query: 1070 AQNNYSEVVQLFLQQH-------PNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTG 1122
+ VVQL L + P AT +G + H+AA G + +I L++
Sbjct: 156 CEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQ----A 211
Query: 1123 VISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHL 1171
I + T L AA G +VVR+L+ +G + N TA+ +
Sbjct: 212 GIDINRQTKSGTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDI 260
Score = 85.8 bits (203), Expect = 1e-15
Identities = 68/225 (30%), Positives = 111/225 (49%), Gaps = 12/225 (5%)
Query: 1095 DGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRA 1154
DG + H AA+ G+ ++I L++ + V NK PL AA G + ++++++A
Sbjct: 48 DGFSALHHAALNGNTELISLLLEA-QAAVDIKDNK--GMRPLHYAAWQGRKEPMKLVLKA 104
Query: 1155 GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETV 1214
G++ + G +HLAA+HGH +V +++ + G TPL +A +G+ V
Sbjct: 105 GSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVV 164
Query: 1215 RELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAA 1274
+ LLS E G + P +G +PLHLAA NG+ +++RLLL AG+ +
Sbjct: 165 QLLLSSNMCAALLEPRPGDATDP-----NGTSPLHLAAKNGHIDIIRLLL-QAGIDINRQ 218
Query: 1275 SNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
+ LH A G +V LLL S H + + +T L I
Sbjct: 219 TKSG--TALHEAALCGKTEVVRLLLD-SGINAHVRNTYSQTALDI 260
Score = 82.6 bits (195), Expect = 1e-14
Identities = 59/188 (31%), Positives = 86/188 (45%), Gaps = 11/188 (5%)
Query: 1244 GLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSA 1303
G + LH AA NGN ++ LLL A D N+ G PLH A + G + L+L +
Sbjct: 49 GFSALHHAALNGNTELISLLLE-AQAAVDIKDNK-GMRPLHYAAWQGRKEPMKLVLKAGS 106
Query: 1304 ELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVK 1363
+ +D G LH+A+ HGHY + E+LL + D +G TPL A + G + VV+
Sbjct: 107 AVNIPSDE-GHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQ 165
Query: 1364 LLCESG-------ASPKSETNLN-CAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFV 1415
LL S P T+ N +P+ AA H D++ LL D +
Sbjct: 166 LLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTAL 225
Query: 1416 YNLMVCSK 1423
+ +C K
Sbjct: 226 HEAALCGK 233
Score = 80.6 bits (190), Expect = 6e-14
Identities = 63/209 (30%), Positives = 108/209 (51%), Gaps = 14/209 (6%)
Query: 892 TAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTN 951
+A H+ A+ GN TE+I+ + A A++ +++ G PL A +G + + +L
Sbjct: 51 SALHHAALNGN----TELISLLLEAQA--AVDIKDNKGMRPLHYAAWQGRKEPMKLVLKA 104
Query: 952 HARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLV 1011
+ V++ EG LHLAA+HG+ V + LL +++ +G+T L LA G +V
Sbjct: 105 GSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVV 164
Query: 1012 KFLIRDH--NAMI-----DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQK 1064
+ L+ + A++ D +PLHLAA +G I++ +LLL+ G +I+ + G
Sbjct: 165 QLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-T 223
Query: 1065 PIHAAAQNNYSEVVQLFLQQHPNLVMATT 1093
+H AA +EVV+L L N + T
Sbjct: 224 ALHEAALCGKTEVVRLLLDSGINAHVRNT 252
Score = 78.2 bits (184), Expect = 3e-13
Identities = 75/265 (28%), Positives = 116/265 (43%), Gaps = 32/265 (12%)
Query: 844 DEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN 903
D DG SALH+A + +++ L+E A V ++ HY A G
Sbjct: 46 DPDGFSALHHAAL---------NGNTELISLLLEAQAAVDIKDNKGMR-PLHYAAWQGRK 95
Query: 904 DVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGR 963
+ M ++ A+N + G PL +A GH + LL + + + D G+
Sbjct: 96 EPMKLVL------KAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGK 149
Query: 964 SALHLAAEHGYLQVCDALLTNK---AFINSKA-----RNGRTALHLAAMNGYAHLVKFLI 1015
+ L LA E G + V LL++ A + + NG + LHLAA NG+ +++ L+
Sbjct: 150 TPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLL 209
Query: 1016 RDHNAMIDV-LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNY 1074
+ A ID+ K T LH AA G+ EV +LLL+ G N + Q + Q
Sbjct: 210 Q---AGIDINRQTKSGTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTT 266
Query: 1075 S----EVVQLFLQQHPNLVMATTKD 1095
S E+ QL + L + TKD
Sbjct: 267 SQASREIKQLLREASAALQVRATKD 291
Score = 74.9 bits (176), Expect = 3e-12
Identities = 47/163 (28%), Positives = 83/163 (50%), Gaps = 9/163 (5%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQT 133
GN ++ LL AQ A +K G LH AA + + ++++ G+ V+ + G
Sbjct: 60 GNTELISLLLEAQAAVDIKDNK--GMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHI 117
Query: 134 PLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE-LLADKFKASIF 192
PLH+AA G + + ++N + DN +TP+ LA E G +++ LL+ A++
Sbjct: 118 PLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALL 177
Query: 193 E-RTKD-----GSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
E R D G++ +H+A+ NGH D +L + G+ ++ K
Sbjct: 178 EPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTK 220
Score = 63.3 bits (147), Expect = 9e-09
Identities = 47/165 (28%), Positives = 81/165 (49%), Gaps = 3/165 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DG ++H AA G+ +I+ LL+ +VD+ N LH A + ++ +L G+
Sbjct: 48 DGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSA 107
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V+I + PLH+AA+ D + MLL+ + P G TP+ +A +FG + +
Sbjct: 108 VNI-PSDEGHIPLHLAAQHGHYD-VSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQ 165
Query: 782 LLLEDG-GDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIE 825
LLL L + + G +PL +A ++ DI+R L++
Sbjct: 166 LLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQ 210
Score = 62.1 bits (144), Expect = 2e-08
Identities = 35/122 (28%), Positives = 60/122 (49%), Gaps = 1/122 (0%)
Query: 1278 NGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGA 1337
+G++ LH A G+ ++ LLL A + D G LH A+ G + ++++L G+
Sbjct: 48 DGFSALHHAALNGNTELISLLLEAQAAV-DIKDNKGMRPLHYAAWQGRKEPMKLVLKAGS 106
Query: 1338 EINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEY 1397
+N G PLH AA+ GH +V ++L + ++P N P+ A V++
Sbjct: 107 AVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQL 166
Query: 1398 LL 1399
LL
Sbjct: 167 LL 168
Score = 58.4 bits (135), Expect = 3e-07
Identities = 32/103 (31%), Positives = 53/103 (51%)
Query: 81 ELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAA 140
+LL + + P G +ALH AA + ++ +L++ A VD + G PLH AA
Sbjct: 32 KLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAW 91
Query: 141 EGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
+G + +K + I +E P+HLAA++GH + E+L
Sbjct: 92 QGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEML 134
Score = 56.4 bits (130), Expect = 1e-06
Identities = 32/102 (31%), Positives = 53/102 (51%), Gaps = 2/102 (1%)
Query: 1310 DRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESG 1369
D G + LH A+ +G+ +++ +LL A ++ D G PLH AA G +KL+ ++G
Sbjct: 46 DPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAG 105
Query: 1370 ASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDD 1411
++ ++ P+ AA H DV E LL +H + M D
Sbjct: 106 SAVNIPSDEGHIPLHLAAQHGHYDVSEMLL--QHQSNPCMVD 145
Score = 56.4 bits (130), Expect = 1e-06
Identities = 48/161 (29%), Positives = 71/161 (44%), Gaps = 11/161 (6%)
Query: 58 LVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQL------KATTPAGDTALHLAARRRDV 111
+V GK PL LA E G +V+ LLS+ L AT P G + LHLAA+ +
Sbjct: 143 MVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHI 202
Query: 112 DMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHL- 170
D+ R+L+ G ++ +G T LH AA G +V+ NA + + +T + +
Sbjct: 203 DIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIV 261
Query: 171 ---AAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLN 208
I +LL + A TKD + SLN
Sbjct: 262 HQFTTSQASREIKQLLREASAALQVRATKDYCNNYDLTSLN 302
Score = 51.2 bits (117), Expect = 4e-05
Identities = 40/140 (28%), Positives = 71/140 (50%), Gaps = 8/140 (5%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G R +H AA G + +L+ G +V++ +++ + LH+A + V E LL + ++
Sbjct: 82 GMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNP 141
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAG------PNKATE-DGMTPVHVAAKFG 775
+ + TPL +A L+L + P AT+ +G +P+H+AAK G
Sbjct: 142 CMVDNSGK-TPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNG 200
Query: 776 NLATLVLLLEDGGDPLRKTK 795
++ + LLL+ G D R+TK
Sbjct: 201 HIDIIRLLLQAGIDINRQTK 220
Score = 49.6 bits (113), Expect = 1e-04
Identities = 44/147 (29%), Positives = 64/147 (43%), Gaps = 8/147 (5%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G +H AA+ GH+ II LLQ G ++ T TALH A K VV LL G +
Sbjct: 188 NGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGIN 246
Query: 722 VHIRGGKQRETPLHIAARIPDGDKC----ALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
H+R +T L I + L+ S A +AT+D + +
Sbjct: 247 AHVR-NTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKDYCNNYDLTSLNVKA 305
Query: 778 ATLVLLLEDGGDPLRKTKVCIYDVVTG 804
++ +LE P + K CI+D TG
Sbjct: 306 GDIITVLEQ--HPDGRWKGCIHDNRTG 330
Score = 39.1 bits (87), Expect = 0.17
Identities = 30/120 (25%), Positives = 55/120 (45%), Gaps = 8/120 (6%)
Query: 1332 LLGQGAEINAT--DKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASE 1389
LLG +IN D +G++ LH AA G+ ++ LL E+ A+ + N P+ +AA +
Sbjct: 33 LLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQ 92
Query: 1390 NHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVL---VSPAPVDTAAK 1446
+ ++ +L D+ +L + H + + E +L +P VD + K
Sbjct: 93 GRKEPMKLVLKAGSAVNIPSDEGHIPLHL---AAQHGHYDVSEMLLQHQSNPCMVDNSGK 149
>BC062346-1|AAH62346.1| 361|Homo sapiens ankyrin repeat domain 16
protein.
Length = 361
Score = 109 bits (263), Expect = 8e-23
Identities = 91/307 (29%), Positives = 146/307 (47%), Gaps = 18/307 (5%)
Query: 995 GRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
G T LH AA +G+ ++ +L I+ + PLH AA+ G + + LL GA
Sbjct: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
+D + P+ A V+Q ++ N ++ KDG HIA+ +G +++
Sbjct: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLL-KNKDGWNSFHIASREGDPLILQY 155
Query: 1115 LMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTD-ENRAGLTAVHLAA 1173
L+ G +K+ TPL AA GH + V+VL++ D + G+TA+ A
Sbjct: 156 LLTV-CPGAWKTESKIR-RTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAI 213
Query: 1174 EHGHTNVLDVMRSTNTLRISSK-KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
+ GH +V ++ + +S++ LG LH AA GQ E +R L+S + G
Sbjct: 214 QCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSEL----------G 263
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHM 1292
V V V + LT LH AA G+ + ++ LL S G + + +E + LHLAC G H+
Sbjct: 264 VD-VDVRATSTHLTALHYAAKEGHTSTIQTLL-SLGADIN-SKDEKNRSALHLACAGQHL 320
Query: 1293 SIVGLLL 1299
+ LL
Sbjct: 321 ACAKFLL 327
Score = 99 bits (238), Expect = 8e-20
Identities = 87/311 (27%), Positives = 137/311 (44%), Gaps = 20/311 (6%)
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
G +H AA++ + +V+ + + AT +D H AA G + L+ R
Sbjct: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLL--GRG 94
Query: 1122 GVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVL 1181
+ K D TPL +A + V++ LV GA+ +N+ G + H+A+ G +L
Sbjct: 95 AAVDCLKKA-DWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLIL 153
Query: 1182 DVMRSTNTLRISSK-KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLG 1240
+ + ++ K+ TPLH AA +G E V+ LL P
Sbjct: 154 QYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRC------------QYEPDYR 201
Query: 1241 AESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLS 1300
G+T L A G+ +V RLLL+ G +A + G LH A G + L+S
Sbjct: 202 DNCGVTALMDAIQCGHIDVARLLLDEHGACL-SAEDSLGAQALHRAAVTGQDEAIRFLVS 260
Query: 1301 R-SAEL-LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGH 1358
++ + +T H T LH A+ GH ++ LL GA+IN+ D+ + LH A H
Sbjct: 261 ELGVDVDVRATSTH-LTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQH 319
Query: 1359 LNVVKLLCESG 1369
L K L +SG
Sbjct: 320 LACAKFLLQSG 330
Score = 96.7 bits (230), Expect = 8e-19
Identities = 89/308 (28%), Positives = 134/308 (43%), Gaps = 21/308 (6%)
Query: 1096 GNTCAHIAAIQGSVKVIEELMKFDRTGV-ISARNKLNDSTPLQLAAEGGHADVVRVLVRA 1154
G+T H AA G V+ L + G+ I A N+ + PL AA GH D VR L+
Sbjct: 37 GDTLLHCAARHGHRDVLAYLA--EAWGMDIEATNR-DYKRPLHEAASMGHRDCVRYLLGR 93
Query: 1155 GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETV 1214
GA+ +A T + +A + V+ + + K G HIA+ G +
Sbjct: 94 GAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLIL 153
Query: 1215 RELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAA 1274
+ LL+ PG K+E+ + TPLH AA +G+ V++LL + D
Sbjct: 154 QYLLTVCPGAWKTES------------KIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYR 201
Query: 1275 SNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVL-- 1332
N G L A GH+ + LLL L + D G LH A+ G + + L
Sbjct: 202 DN-CGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVS 260
Query: 1333 -LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENH 1391
LG ++ AT + T LH AAK GH + ++ L GA S+ N + + A + H
Sbjct: 261 ELGVDVDVRATSTH-LTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQH 319
Query: 1392 NDVLEYLL 1399
++LL
Sbjct: 320 LACAKFLL 327
Score = 94.3 bits (224), Expect = 4e-18
Identities = 78/297 (26%), Positives = 141/297 (47%), Gaps = 14/297 (4%)
Query: 869 RQVVKCLIEN-GADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNS 927
R V+ L E G D+ T +++ H A G+ D + ++ + D + +
Sbjct: 50 RDVLAYLAEAWGMDIEA-TNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKAD---- 104
Query: 928 IGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLT-NKA 986
WTPL++AC R ++ ++ L+ + A + + +G ++ H+A+ G + LLT
Sbjct: 105 --WTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPG 162
Query: 987 FINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCK 1046
++++ RT LH AAM+G+ VK L++ D T L A G I+V +
Sbjct: 163 AWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVAR 222
Query: 1047 LLL-ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ-HPNLVMATTKDGNTCAHIAA 1104
LLL E GA + A D LG + +H AA E ++ + + ++ + T T H AA
Sbjct: 223 LLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAA 282
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDE 1161
+G I+ L+ I+++++ N S L LA G H + L+++G +++
Sbjct: 283 KEGHTSTIQTLLSLGAD--INSKDEKNRSA-LHLACAGQHLACAKFLLQSGLKDSED 336
Score = 86.6 bits (205), Expect = 8e-16
Identities = 76/262 (29%), Positives = 116/262 (44%), Gaps = 7/262 (2%)
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
G + LH AA HG+ V L I + R+ + LH AA G+ V++L+ A
Sbjct: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLL-GRGA 95
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQL 1080
+D L TPL +A + V + L+E GAN ++ G H A++ ++Q
Sbjct: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
Query: 1081 FLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAA 1140
L P +K T H AA+ G ++ ++ L+K R T L A
Sbjct: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLK--RCQYEPDYRDNCGVTALMDAI 213
Query: 1141 EGGHADVVRVLV-RAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLG- 1198
+ GH DV R+L+ GA + E+ G A+H AA G + + S + + +
Sbjct: 214 QCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATST 273
Query: 1199 -LTPLHIAAYYGQAETVRELLS 1219
LT LH AA G T++ LLS
Sbjct: 274 HLTALHYAAKEGHTSTIQTLLS 295
Score = 81.8 bits (193), Expect = 2e-14
Identities = 82/296 (27%), Positives = 121/296 (40%), Gaps = 19/296 (6%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T L AA GH DV+ L A G NR +H AA GH + + +
Sbjct: 39 TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
KK TPL +A ++EL+ H G + P+L + G H+A+
Sbjct: 99 CLKKADWTPLMMACTRKNLGVIQELVEH-----------GAN--PLLKNKDGWNSFHIAS 145
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
G+ +++ LL A ++ PLH A GH+ V +LL R D
Sbjct: 146 REGDPLILQYLLTVCP-GAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNC 204
Query: 1313 GKTGLHIASTHGHYQMVEVLLGQ-GAEINATDKNGWTPLHCAAKAGHLNVVK-LLCESGA 1370
G T L A GH + +LL + GA ++A D G LH AA G ++ L+ E G
Sbjct: 205 GVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGV 264
Query: 1371 SPKSE-TNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNH 1425
T+ + + +AA E H ++ LL D S + R +L C+ H
Sbjct: 265 DVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHL-ACAGQH 319
Score = 77.4 bits (182), Expect = 5e-13
Identities = 70/239 (29%), Positives = 110/239 (46%), Gaps = 18/239 (7%)
Query: 1164 AGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGL-TPLHIAAYYGQAETVRELLSHVP 1222
AG T +H AA HGH +VL + + I + PLH AA G + VR LL
Sbjct: 36 AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGR-- 93
Query: 1223 GTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNP 1282
G ++ + A+ TPL +A N V++ L+ N++G+N
Sbjct: 94 ---------GAAVDCLKKAD--WTPLMMACTRKNLGVIQELVEHGA--NPLLKNKDGWNS 140
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQ-GAEINA 1341
H+A G I+ LL+ + + +T LH A+ HGH + V+VLL + E +
Sbjct: 141 FHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDY 200
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLC-ESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
D G T L A + GH++V +LL E GA +E +L + AA ++ + +L+
Sbjct: 201 RDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLV 259
Score = 72.5 bits (170), Expect = 1e-11
Identities = 88/317 (27%), Positives = 135/317 (42%), Gaps = 35/317 (11%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
D R +H AA GH + LL +G +VD ++T L +A V++ L+ +GA+
Sbjct: 70 DYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGAN 129
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLAT 779
++ K HIA+R +GD L L + TE + TP+H AA G+L
Sbjct: 130 PLLK-NKDGWNSFHIASR--EGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEA 186
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF 839
+ +LL+ R Y G T L A + D+ R L+ D G A
Sbjct: 187 VKVLLK------RCQYEPDYRDNCGVTALMDAIQCGHIDVARLLL----DEHG-----AC 231
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+ A D GA ALH A ++E A R +V E G DV ++ H TA HY A
Sbjct: 232 LSAEDSLGAQALHRAAVTGQDE-----AIRFLVS---ELGVDVDVRATSTHLTALHYAAK 283
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
G+ + +++ + +N ++ + L +AC H+ LL + + D D
Sbjct: 284 EGHTSTIQTLLS------LGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLK-DSED 336
Query: 960 VEGRSALHLAAEHGYLQ 976
+ G A L LQ
Sbjct: 337 ITGTLAQQLPRRADVLQ 353
Score = 64.1 bits (149), Expect = 5e-09
Identities = 41/115 (35%), Positives = 57/115 (49%), Gaps = 2/115 (1%)
Query: 96 PAGDTALHLAARRRDVDMARILVD-YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVR 154
PAGDT LH AAR D+ L + +G ++ATN + PLH AA+ G V+Y G
Sbjct: 35 PAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRG 94
Query: 155 ANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNG 209
A D TP+ +A + +I+ L + A+ + KDG HIAS G
Sbjct: 95 AAVDCLKKADWTPLMMACTRKNLGVIQELVE-HGANPLLKNKDGWNSFHIASREG 148
Score = 63.3 bits (147), Expect = 9e-09
Identities = 48/155 (30%), Positives = 75/155 (48%), Gaps = 3/155 (1%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
K PL A G++ VR LL A + A T L +A R+++ + + LV++GA
Sbjct: 72 KRPLHEAASMGHRDCVRYLLGRGAA--VDCLKKADWTPLMMACTRKNLGVIQELVEHGAN 129
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE-DRTPMHLAAENGHAAIIEL 182
N G HIA+ EGD +++Y V A +++ RTP+H AA +GH +++
Sbjct: 130 PLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKV 189
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
L + + R G T + A GH D A +L
Sbjct: 190 LLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLL 224
Score = 60.1 bits (139), Expect = 8e-08
Identities = 47/163 (28%), Positives = 75/163 (46%), Gaps = 7/163 (4%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVD-YGA 122
+ PL A G+ V+ LL E G TAL A + +D+AR+L+D +GA
Sbjct: 172 RTPLHTAAMHGHLEAVKVLLKRCQYEP-DYRDNCGVTALMDAIQCGHIDVARLLLDEHGA 230
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFY---GVRANAAIADNEDRTPMHLAAENGHAAI 179
+ A + G LH AA G + +++ GV + A + T +H AA+ GH +
Sbjct: 231 CLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVR-ATSTHLTALHYAAKEGHTST 289
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGV 222
I+ L A I + + + +H+A H CA L + G+
Sbjct: 290 IQTLLS-LGADINSKDEKNRSALHLACAGQHLACAKFLLQSGL 331
Score = 53.2 bits (122), Expect = 1e-05
Identities = 40/161 (24%), Positives = 69/161 (42%), Gaps = 1/161 (0%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A G++ ++ L A + ++AT LH AA D R L+ GA
Sbjct: 37 GDTLLHCAARHGHRDVLAYLAEAWGMD-IEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VD A TPL +A + +++ AN + + + H+A+ G I++
Sbjct: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
L + +K T +H A+++GH + +L K+ Y
Sbjct: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQY 196
Score = 47.2 bits (107), Expect = 6e-04
Identities = 38/123 (30%), Positives = 54/123 (43%), Gaps = 3/123 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV-DYG 121
G L+ A++ G+ + R LL A L A G ALH AA + R LV + G
Sbjct: 205 GVTALMDAIQCGHIDVARLLLDEHGA-CLSAEDSLGAQALHRAAVTGQDEAIRFLVSELG 263
Query: 122 AVVDA-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
VD T LH AA EG ++ + A+ D ++R+ +HLA H A
Sbjct: 264 VDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACA 323
Query: 181 ELL 183
+ L
Sbjct: 324 KFL 326
Score = 40.7 bits (91), Expect = 0.055
Identities = 39/154 (25%), Positives = 63/154 (40%), Gaps = 4/154 (2%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL++A N +++EL+ LK G + H+A+R D + + L+
Sbjct: 107 PLMMACTRKNLGVIQELVEHGANPLLK--NKDGWNSFHIASREGDPLILQYLLTVCPGAW 164
Query: 126 ATNGA-GQTPLHIAAAEGDEPLVKYFYG-VRANAAIADNEDRTPMHLAAENGHAAIIELL 183
T +TPLH AA G VK + DN T + A + GH + LL
Sbjct: 165 KTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLL 224
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
D+ A + G+ +H A++ G + L
Sbjct: 225 LDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFL 258
>AL137186-4|CAI41072.1| 361|Homo sapiens ankyrin repeat domain 16
protein.
Length = 361
Score = 109 bits (263), Expect = 8e-23
Identities = 91/307 (29%), Positives = 146/307 (47%), Gaps = 18/307 (5%)
Query: 995 GRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
G T LH AA +G+ ++ +L I+ + PLH AA+ G + + LL GA
Sbjct: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
+D + P+ A V+Q ++ N ++ KDG HIA+ +G +++
Sbjct: 97 VDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLL-KNKDGWNSFHIASREGDPLILQY 155
Query: 1115 LMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTD-ENRAGLTAVHLAA 1173
L+ G +K+ TPL AA GH + V+VL++ D + G+TA+ A
Sbjct: 156 LLTV-CPGAWKTESKIR-RTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAI 213
Query: 1174 EHGHTNVLDVMRSTNTLRISSK-KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
+ GH +V ++ + +S++ LG LH AA GQ E +R L+S + G
Sbjct: 214 QCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSEL----------G 263
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHM 1292
V V V + LT LH AA G+ + ++ LL S G + + +E + LHLAC G H+
Sbjct: 264 VD-VDVRATSTHLTALHYAAKEGHTSTIQTLL-SLGADIN-SKDEKNRSALHLACAGQHL 320
Query: 1293 SIVGLLL 1299
+ LL
Sbjct: 321 ACAKFLL 327
Score = 99 bits (238), Expect = 8e-20
Identities = 87/311 (27%), Positives = 137/311 (44%), Gaps = 20/311 (6%)
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
G +H AA++ + +V+ + + AT +D H AA G + L+ R
Sbjct: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLL--GRG 94
Query: 1122 GVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVL 1181
+ K D TPL +A + V++ LV GA+ +N+ G + H+A+ G +L
Sbjct: 95 AAVDCLKKA-DWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLIL 153
Query: 1182 DVMRSTNTLRISSK-KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLG 1240
+ + ++ K+ TPLH AA +G E V+ LL P
Sbjct: 154 QYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRC------------QYEPDYR 201
Query: 1241 AESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLS 1300
G+T L A G+ +V RLLL+ G +A + G LH A G + L+S
Sbjct: 202 DNCGVTALMDAIQCGHIDVARLLLDEHGACL-SAEDSLGAQALHRAAVTGQDEAIRFLVS 260
Query: 1301 R-SAEL-LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGH 1358
++ + +T H T LH A+ GH ++ LL GA+IN+ D+ + LH A H
Sbjct: 261 ELGVDVDVRATSTH-LTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQH 319
Query: 1359 LNVVKLLCESG 1369
L K L +SG
Sbjct: 320 LACAKFLLQSG 330
Score = 96.7 bits (230), Expect = 8e-19
Identities = 89/308 (28%), Positives = 134/308 (43%), Gaps = 21/308 (6%)
Query: 1096 GNTCAHIAAIQGSVKVIEELMKFDRTGV-ISARNKLNDSTPLQLAAEGGHADVVRVLVRA 1154
G+T H AA G V+ L + G+ I A N+ + PL AA GH D VR L+
Sbjct: 37 GDTLLHCAARHGHRDVLAYLA--EAWGMDIEATNR-DYKRPLHEAASMGHRDCVRYLLGR 93
Query: 1155 GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETV 1214
GA+ +A T + +A + V+ + + K G HIA+ G +
Sbjct: 94 GAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLIL 153
Query: 1215 RELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAA 1274
+ LL+ PG K+E+ + TPLH AA +G+ V++LL + D
Sbjct: 154 QYLLTVCPGAWKTES------------KIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYR 201
Query: 1275 SNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVL-- 1332
N G L A GH+ + LLL L + D G LH A+ G + + L
Sbjct: 202 DN-CGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVS 260
Query: 1333 -LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENH 1391
LG ++ AT + T LH AAK GH + ++ L GA S+ N + + A + H
Sbjct: 261 ELGVDVDVRATSTH-LTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQH 319
Query: 1392 NDVLEYLL 1399
++LL
Sbjct: 320 LACAKFLL 327
Score = 94.3 bits (224), Expect = 4e-18
Identities = 78/297 (26%), Positives = 141/297 (47%), Gaps = 14/297 (4%)
Query: 869 RQVVKCLIEN-GADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNS 927
R V+ L E G D+ T +++ H A G+ D + ++ + D + +
Sbjct: 50 RDVLAYLAEAWGMDIEA-TNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKAD---- 104
Query: 928 IGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLT-NKA 986
WTPL++AC R ++ ++ L+ + A + + +G ++ H+A+ G + LLT
Sbjct: 105 --WTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPG 162
Query: 987 FINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCK 1046
++++ RT LH AAM+G+ VK L++ D T L A G I+V +
Sbjct: 163 AWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVAR 222
Query: 1047 LLL-ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ-HPNLVMATTKDGNTCAHIAA 1104
LLL E GA + A D LG + +H AA E ++ + + ++ + T T H AA
Sbjct: 223 LLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAA 282
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDE 1161
+G I+ L+ I+++++ N S L LA G H + L+++G +++
Sbjct: 283 KEGHTSTIQTLLSLGAD--INSKDEKNRSA-LHLACAGQHLACAKFLLQSGLKDSED 336
Score = 86.6 bits (205), Expect = 8e-16
Identities = 76/262 (29%), Positives = 116/262 (44%), Gaps = 7/262 (2%)
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
G + LH AA HG+ V L I + R+ + LH AA G+ V++L+ A
Sbjct: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLL-GRGA 95
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQL 1080
+D L TPL +A + V + L+E GAN ++ G H A++ ++Q
Sbjct: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
Query: 1081 FLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAA 1140
L P +K T H AA+ G ++ ++ L+K R T L A
Sbjct: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLK--RCQYEPDYRDNCGVTALMDAI 213
Query: 1141 EGGHADVVRVLV-RAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLG- 1198
+ GH DV R+L+ GA + E+ G A+H AA G + + S + + +
Sbjct: 214 QCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATST 273
Query: 1199 -LTPLHIAAYYGQAETVRELLS 1219
LT LH AA G T++ LLS
Sbjct: 274 HLTALHYAAKEGHTSTIQTLLS 295
Score = 81.8 bits (193), Expect = 2e-14
Identities = 82/296 (27%), Positives = 121/296 (40%), Gaps = 19/296 (6%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T L AA GH DV+ L A G NR +H AA GH + + +
Sbjct: 39 TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVD 98
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
KK TPL +A ++EL+ H G + P+L + G H+A+
Sbjct: 99 CLKKADWTPLMMACTRKNLGVIQELVEH-----------GAN--PLLKNKDGWNSFHIAS 145
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
G+ +++ LL A ++ PLH A GH+ V +LL R D
Sbjct: 146 REGDPLILQYLLTVCP-GAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNC 204
Query: 1313 GKTGLHIASTHGHYQMVEVLLGQ-GAEINATDKNGWTPLHCAAKAGHLNVVK-LLCESGA 1370
G T L A GH + +LL + GA ++A D G LH AA G ++ L+ E G
Sbjct: 205 GVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGV 264
Query: 1371 SPKSE-TNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNH 1425
T+ + + +AA E H ++ LL D S + R +L C+ H
Sbjct: 265 DVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHL-ACAGQH 319
Score = 77.4 bits (182), Expect = 5e-13
Identities = 70/239 (29%), Positives = 110/239 (46%), Gaps = 18/239 (7%)
Query: 1164 AGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGL-TPLHIAAYYGQAETVRELLSHVP 1222
AG T +H AA HGH +VL + + I + PLH AA G + VR LL
Sbjct: 36 AGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGR-- 93
Query: 1223 GTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNP 1282
G ++ + A+ TPL +A N V++ L+ N++G+N
Sbjct: 94 ---------GAAVDCLKKAD--WTPLMMACTRKNLGVIQELVEHGA--NPLLKNKDGWNS 140
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQ-GAEINA 1341
H+A G I+ LL+ + + +T LH A+ HGH + V+VLL + E +
Sbjct: 141 FHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDY 200
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLC-ESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
D G T L A + GH++V +LL E GA +E +L + AA ++ + +L+
Sbjct: 201 RDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLV 259
Score = 72.5 bits (170), Expect = 1e-11
Identities = 88/317 (27%), Positives = 135/317 (42%), Gaps = 35/317 (11%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
D R +H AA GH + LL +G +VD ++T L +A V++ L+ +GA+
Sbjct: 70 DYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGAN 129
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLAT 779
++ K HIA+R +GD L L + TE + TP+H AA G+L
Sbjct: 130 PLLK-NKDGWNSFHIASR--EGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEA 186
Query: 780 LVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAF 839
+ +LL+ R Y G T L A + D+ R L+ D G A
Sbjct: 187 VKVLLK------RCQYEPDYRDNCGVTALMDAIQCGHIDVARLLL----DEHG-----AC 231
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+ A D GA ALH A ++E A R +V E G DV ++ H TA HY A
Sbjct: 232 LSAEDSLGAQALHRAAVTGQDE-----AIRFLVS---ELGVDVDVRATSTHLTALHYAAK 283
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
G+ + +++ + +N ++ + L +AC H+ LL + + D D
Sbjct: 284 EGHTSTIQTLLS------LGADINSKDEKNRSALHLACAGQHLACAKFLLQSGLK-DSED 336
Query: 960 VEGRSALHLAAEHGYLQ 976
+ G A L LQ
Sbjct: 337 ITGTLAQQLPRRADVLQ 353
Score = 64.1 bits (149), Expect = 5e-09
Identities = 41/115 (35%), Positives = 57/115 (49%), Gaps = 2/115 (1%)
Query: 96 PAGDTALHLAARRRDVDMARILVD-YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVR 154
PAGDT LH AAR D+ L + +G ++ATN + PLH AA+ G V+Y G
Sbjct: 35 PAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRG 94
Query: 155 ANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNG 209
A D TP+ +A + +I+ L + A+ + KDG HIAS G
Sbjct: 95 AAVDCLKKADWTPLMMACTRKNLGVIQELVE-HGANPLLKNKDGWNSFHIASREG 148
Score = 63.3 bits (147), Expect = 9e-09
Identities = 48/155 (30%), Positives = 75/155 (48%), Gaps = 3/155 (1%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
K PL A G++ VR LL A + A T L +A R+++ + + LV++GA
Sbjct: 72 KRPLHEAASMGHRDCVRYLLGRGAA--VDCLKKADWTPLMMACTRKNLGVIQELVEHGAN 129
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE-DRTPMHLAAENGHAAIIEL 182
N G HIA+ EGD +++Y V A +++ RTP+H AA +GH +++
Sbjct: 130 PLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKV 189
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
L + + R G T + A GH D A +L
Sbjct: 190 LLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLL 224
Score = 60.1 bits (139), Expect = 8e-08
Identities = 47/163 (28%), Positives = 75/163 (46%), Gaps = 7/163 (4%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVD-YGA 122
+ PL A G+ V+ LL E G TAL A + +D+AR+L+D +GA
Sbjct: 172 RTPLHTAAMHGHLEAVKVLLKRCQYEP-DYRDNCGVTALMDAIQCGHIDVARLLLDEHGA 230
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFY---GVRANAAIADNEDRTPMHLAAENGHAAI 179
+ A + G LH AA G + +++ GV + A + T +H AA+ GH +
Sbjct: 231 CLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDVDVR-ATSTHLTALHYAAKEGHTST 289
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGV 222
I+ L A I + + + +H+A H CA L + G+
Sbjct: 290 IQTLLS-LGADINSKDEKNRSALHLACAGQHLACAKFLLQSGL 331
Score = 53.2 bits (122), Expect = 1e-05
Identities = 40/161 (24%), Positives = 69/161 (42%), Gaps = 1/161 (0%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A G++ ++ L A + ++AT LH AA D R L+ GA
Sbjct: 37 GDTLLHCAARHGHRDVLAYLAEAWGMD-IEATNRDYKRPLHEAASMGHRDCVRYLLGRGA 95
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
VD A TPL +A + +++ AN + + + H+A+ G I++
Sbjct: 96 AVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREGDPLILQY 155
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
L + +K T +H A+++GH + +L K+ Y
Sbjct: 156 LLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQY 196
Score = 47.2 bits (107), Expect = 6e-04
Identities = 38/123 (30%), Positives = 54/123 (43%), Gaps = 3/123 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV-DYG 121
G L+ A++ G+ + R LL A L A G ALH AA + R LV + G
Sbjct: 205 GVTALMDAIQCGHIDVARLLLDEHGA-CLSAEDSLGAQALHRAAVTGQDEAIRFLVSELG 263
Query: 122 AVVDA-TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
VD T LH AA EG ++ + A+ D ++R+ +HLA H A
Sbjct: 264 VDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACA 323
Query: 181 ELL 183
+ L
Sbjct: 324 KFL 326
Score = 40.7 bits (91), Expect = 0.055
Identities = 39/154 (25%), Positives = 63/154 (40%), Gaps = 4/154 (2%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL++A N +++EL+ LK G + H+A+R D + + L+
Sbjct: 107 PLMMACTRKNLGVIQELVEHGANPLLK--NKDGWNSFHIASREGDPLILQYLLTVCPGAW 164
Query: 126 ATNGA-GQTPLHIAAAEGDEPLVKYFYG-VRANAAIADNEDRTPMHLAAENGHAAIIELL 183
T +TPLH AA G VK + DN T + A + GH + LL
Sbjct: 165 KTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLL 224
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
D+ A + G+ +H A++ G + L
Sbjct: 225 LDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFL 258
>AB046856-1|BAB13462.2| 1864|Homo sapiens KIAA1636 protein protein.
Length = 1864
Score = 109 bits (262), Expect = 1e-22
Identities = 95/304 (31%), Positives = 141/304 (46%), Gaps = 20/304 (6%)
Query: 933 LLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKA 992
L + H G+ ++V LL A VD G + L AA GYL + L +A ++
Sbjct: 763 LCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLD 822
Query: 993 RNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVL--TLKK----QTPLHLAAASGQIEVCK 1046
+NG+ AL AA+ G+ +VKFLI+ M KK Q L AA+ G E+
Sbjct: 823 KNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVS 882
Query: 1047 LLLELG---------ANIDATDEL-GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDG 1096
LL+L A I++ D L G+ + AAA EV +L L+Q V + G
Sbjct: 883 YLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGA-AVAQPNRRG 941
Query: 1097 NTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGA 1156
QG ++++ L+ ++ +K TPL +AA GH V L+ GA
Sbjct: 942 AVPLFSTVRQGHWQIVDLLLTHGAD--VNMADK-QGRTPLMMAASEGHLGTVDFLLAQGA 998
Query: 1157 SCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRE 1216
S ++ GLTA+ A GH +V+ + + K G TPL +AA+YG AE V+
Sbjct: 999 SIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQF 1058
Query: 1217 LLSH 1220
L+ H
Sbjct: 1059 LVDH 1062
Score = 107 bits (256), Expect = 6e-22
Identities = 124/454 (27%), Positives = 204/454 (44%), Gaps = 27/454 (5%)
Query: 676 VGIINTLLQKGESVDVTTNDNYTALHIAVESCKP--AVVETLLGYGADVHIRGGKQRETP 733
VG+ +++LQ G + +T AL P V L+ GA+++ R P
Sbjct: 703 VGVSSSILQ-GLWISYSTEGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAP 761
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
+ + +LL+ GA + ++E G+TP+ AA G L+ +VLL + ++
Sbjct: 762 ILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCK------KR 815
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVST-AFIDAVDED--GASA 850
KV D G+ L A ++V+ LI+ G+ A+ + A++
Sbjct: 816 AKVDHLDK-NGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAAS 874
Query: 851 LHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMI 910
+ Y ++ + +P D + V+ N D SL ETA A G +V ++
Sbjct: 875 MGYT-EIVSYLLDLPEKDEEEVERAQINSFD-SLWG----ETALTAAAGRGKLEVCRLLL 928
Query: 911 AHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAA 970
+ A+ + N G PL +GH Q+V+ LLT+ A V++ D +GR+ L +AA
Sbjct: 929 ------EQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAA 982
Query: 971 EHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQ 1030
G+L D LL A I + G TAL A + G+ +V+ L+ D+ A D +
Sbjct: 983 SEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLV-DNGAATDHADKNGR 1041
Query: 1031 TPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVM 1090
TPL LAA G EV + L++ GA I+ D G +P+ A + VV L++ +
Sbjct: 1042 TPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGP 1101
Query: 1091 ATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVI 1124
AT + I I S K++EE F + G +
Sbjct: 1102 ATWAMATSKPDIMIILLS-KLMEEGDMFYKKGKV 1134
Score = 98.3 bits (234), Expect = 3e-19
Identities = 90/300 (30%), Positives = 134/300 (44%), Gaps = 16/300 (5%)
Query: 1107 GSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGL 1166
G +++ L++F S+ + L TPL AA G+ +V +L + A ++ G
Sbjct: 770 GYTEMVALLLEFGANVDASSESGL---TPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQ 826
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHI-------AAYYGQAETVRELLS 1219
A+ AA GH V+ + + ++ H AA G E V LL
Sbjct: 827 CALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLD 886
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
+P K E + + + G T L AA G V RLLL A A N G
Sbjct: 887 -LPE--KDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGA--AVAQPNRRG 941
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
PL GH IV LLL+ A++ + D+ G+T L +A++ GH V+ LL QGA I
Sbjct: 942 AVPLFSTVRQGHWQIVDLLLTHGADV-NMADKQGRTPLMMAASEGHLGTVDFLLAQGASI 1000
Query: 1340 NATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
DK G T L A GHL+VV+ L ++GA+ P+ AA +V+++L+
Sbjct: 1001 ALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLV 1060
Score = 89.4 bits (212), Expect = 1e-16
Identities = 106/379 (27%), Positives = 158/379 (41%), Gaps = 39/379 (10%)
Query: 1042 IEVCKLLLELGANID-ATDELGQKPIHAAAQN-NYSEVVQLFLQQHPNLVMATTKDGNTC 1099
I+V +LL+ GANI+ T+ L PI + Y+E+V L L+ N V A+++ G T
Sbjct: 737 IKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGAN-VDASSESGLTP 795
Query: 1100 AHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
AA G + ++ L K + + +K N L AA GH +VV+ L++ +
Sbjct: 796 LGYAAAAGYLSIVVLLCK--KRAKVDHLDK-NGQCALVHAALRGHLEVVKFLIQCDWTMA 852
Query: 1160 DENRAGLTAVHL-------AAEHGHTNVLDVM--------RSTNTLRISS--KKLGLTPL 1202
+ + H AA G+T ++ + +I+S G T L
Sbjct: 853 GQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETAL 912
Query: 1203 HIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRL 1262
AA G+ E R LL + G PL G+ +V L
Sbjct: 913 TAAAGRGKLEVCRLLLEQGAAVAQPN-------------RRGAVPLFSTVRQGHWQIVDL 959
Query: 1263 LLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIAST 1322
LL G + A + G PL +A GH+ V LL++ A + D+ G T L A
Sbjct: 960 LLTH-GADVNMADKQ-GRTPLMMAASEGHLGTVDFLLAQGASIA-LMDKEGLTALSWACL 1016
Query: 1323 HGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAP 1382
GH +V L+ GA + DKNG TPL AA G VV+ L + GA + P
Sbjct: 1017 KGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRP 1076
Query: 1383 IWFAASENHNDVLEYLLHK 1401
+ A + V+ LL K
Sbjct: 1077 LDRAVGCRNTSVVVTLLKK 1095
Score = 85.0 bits (201), Expect = 3e-15
Identities = 91/349 (26%), Positives = 147/349 (42%), Gaps = 35/349 (10%)
Query: 973 GYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTP 1032
GY ++ LL A +++ + +G T L AA GY +V L + A +D L Q
Sbjct: 770 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKR-AKVDHLDKNGQCA 828
Query: 1033 LHLAAASGQIEVCKLLLELGANIDATDELGQKPIHA-------AAQNNYSEVVQLFL--- 1082
L AA G +EV K L++ + + K HA AA Y+E+V L
Sbjct: 829 LVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLP 888
Query: 1083 ---QQHPNLVMATTKD---GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPL 1136
++ + D G T AA +G ++V L++ G A+ + PL
Sbjct: 889 EKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLE---QGAAVAQPNRRGAVPL 945
Query: 1137 QLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
GH +V +L+ GA ++ G T + +AA GH +D + + K
Sbjct: 946 FSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDK 1005
Query: 1197 LGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGN 1256
GLT L A G VR L+ + T ++ ++G TPL LAA+ G+
Sbjct: 1006 EGLTALSWACLKGHLSVVRSLVDNGAATDHAD-------------KNGRTPLDLAAFYGD 1052
Query: 1257 ENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
VV+ L++ + + +G PL A + S+V LL + A++
Sbjct: 1053 AEVVQFLVDHGAMIEHV--DYSGMRPLDRAVGCRNTSVVVTLLKKGAKI 1099
Score = 75.8 bits (178), Expect = 2e-12
Identities = 86/329 (26%), Positives = 141/329 (42%), Gaps = 29/329 (8%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
++V L+E GA+V + T Y A AG ++ + + D + G
Sbjct: 773 EMVALLLEFGANVDASSESGL-TPLGYAAAAGYLSIVVLLCKKRAKVD------HLDKNG 825
Query: 930 WTPLLIACHRGHMQLVNTLLTNH-----ARVDVFDVEG--RSALHLAAEHGYLQVCDALL 982
L+ A RGH+++V L+ + VF + AL AA GY ++ LL
Sbjct: 826 QCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLL 885
Query: 983 ---------TNKAFINS-KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTP 1032
+A INS + G TAL AA G + + L+ + A + + P
Sbjct: 886 DLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLL-EQGAAVAQPNRRGAVP 944
Query: 1033 LHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMAT 1092
L G ++ LLL GA+++ D+ G+ P+ AA + V L Q ++ +
Sbjct: 945 LFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMD 1004
Query: 1093 TKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
K+G T A ++G + V+ L+ G + N TPL LAA G A+VV+ LV
Sbjct: 1005 -KEGLTALSWACLKGHLSVVRSLVD---NGAATDHADKNGRTPLDLAAFYGDAEVVQFLV 1060
Query: 1153 RAGASCTDENRAGLTAVHLAAEHGHTNVL 1181
GA + +G+ + A +T+V+
Sbjct: 1061 DHGAMIEHVDYSGMRPLDRAVGCRNTSVV 1089
Score = 67.7 bits (158), Expect = 4e-10
Identities = 41/124 (33%), Positives = 60/124 (48%), Gaps = 1/124 (0%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G+TAL AA R +++ R+L++ GA V N G PL +G +V A+
Sbjct: 908 GETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADV 967
Query: 158 AIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+AD + RTP+ +AA GH ++ L + ASI K+G T + A L GH L
Sbjct: 968 NMADKQGRTPLMMAASEGHLGTVDFLLAQ-GASIALMDKEGLTALSWACLKGHLSVVRSL 1026
Query: 218 FKKG 221
G
Sbjct: 1027 VDNG 1030
Score = 58.0 bits (134), Expect = 3e-07
Identities = 43/162 (26%), Positives = 70/162 (43%), Gaps = 3/162 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L A G + R LL A + G L R+ + +L+ +GA
Sbjct: 908 GETALTAAAGRGKLEVCRLLLEQGAA--VAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGA 965
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+ + G+TPL +AA+EG V + A+ A+ D E T + A GH +++
Sbjct: 966 DVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRS 1025
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
L D A+ K+G T + +A+ G A+ L G +
Sbjct: 1026 LVDN-GAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMI 1066
Score = 56.0 bits (129), Expect = 1e-06
Identities = 35/111 (31%), Positives = 63/111 (56%), Gaps = 3/111 (2%)
Query: 1291 HMSIVGLLLSRSAELLHSTDRHGKTGLHIASTH-GHYQMVEVLLGQGAEINATDKNGWTP 1349
++ + LL+ A + + T+ + +H G+ +MV +LL GA ++A+ ++G TP
Sbjct: 736 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 795
Query: 1350 LHCAAKAGHLNVVKLLCESGAS-PKSETNLNCAPIWFAASENHNDVLEYLL 1399
L AA AG+L++V LLC+ A + N CA + AA H +V+++L+
Sbjct: 796 LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALV-HAALRGHLEVVKFLI 845
Score = 52.0 bits (119), Expect = 2e-05
Identities = 37/126 (29%), Positives = 59/126 (46%), Gaps = 2/126 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G+ PL++A G+ V + L AQ A + G TAL A + + + R LVD
Sbjct: 972 KQGRTPLMMAASEGHLGTV-DFLLAQGAS-IALMDKEGLTALSWACLKGHLSVVRSLVDN 1029
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA D + G+TPL +AA GD +V++ A D P+ A + +++
Sbjct: 1030 GAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVV 1089
Query: 181 ELLADK 186
L K
Sbjct: 1090 VTLLKK 1095
Score = 49.2 bits (112), Expect = 2e-04
Identities = 38/125 (30%), Positives = 56/125 (44%), Gaps = 2/125 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+RG VPL V G+ +V +LL A+ + G T L +AA + L+
Sbjct: 939 RRGAVPLFSTVRQGHWQIV-DLLLTHGAD-VNMADKQGRTPLMMAASEGHLGTVDFLLAQ 996
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA + + G T L A +G +V+ A AD RTP+ LAA G A ++
Sbjct: 997 GASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVV 1056
Query: 181 ELLAD 185
+ L D
Sbjct: 1057 QFLVD 1061
Score = 48.8 bits (111), Expect = 2e-04
Identities = 38/125 (30%), Positives = 56/125 (44%), Gaps = 2/125 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G + AA GH+G ++ LL +G S+ + + TAL A +VV +L+ GA
Sbjct: 974 GRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAAT 1033
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
K TPL +AA D + L+ GA GM P+ A N + +V
Sbjct: 1034 D-HADKNGRTPLDLAAFYGDAE-VVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVT 1091
Query: 783 LLEDG 787
LL+ G
Sbjct: 1092 LLKKG 1096
Score = 46.0 bits (104), Expect = 0.001
Identities = 44/164 (26%), Positives = 75/164 (45%), Gaps = 11/164 (6%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA G + + LL++G +V L V +V+ LL +GADV
Sbjct: 908 GETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADV 967
Query: 723 HIRGGKQRETPLHIAARIPDGDKCAL-MLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
++ KQ TPL +AA +G + LL GA ++G+T + A G+L+ +
Sbjct: 968 NM-ADKQGRTPLMMAA--SEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVR 1024
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIE 825
L+++G K G TPL +A ++V+ L++
Sbjct: 1025 SLVDNGAATDHADK-------NGRTPLDLAAFYGDAEVVQFLVD 1061
Score = 42.3 bits (95), Expect = 0.018
Identities = 24/72 (33%), Positives = 38/72 (52%)
Query: 112 DMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLA 171
+M +L+++GA VDA++ +G TPL AAA G +V RA D + + A
Sbjct: 773 EMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHA 832
Query: 172 AENGHAAIIELL 183
A GH +++ L
Sbjct: 833 ALRGHLEVVKFL 844
Score = 35.1 bits (77), Expect = 2.7
Identities = 28/112 (25%), Positives = 51/112 (45%), Gaps = 3/112 (2%)
Query: 110 DVDMARILVDYGAVVD-ATNGAGQTP-LHIAAAEGDEPLVKYFYGVRANAAIADNEDRTP 167
++ ++R+L+ GA ++ T P L + + G +V AN + TP
Sbjct: 736 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 795
Query: 168 MHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
+ AA G+ +I+ LL K +A + K+G + A+L GH + L +
Sbjct: 796 LGYAAAAGYLSIVVLLCKK-RAKVDHLDKNGQCALVHAALRGHLEVVKFLIQ 846
>BC110582-1|AAI10583.1| 1006|Homo sapiens mindbomb homolog 1
(Drosophila) protein.
Length = 1006
Score = 109 bits (261), Expect = 1e-22
Identities = 82/271 (30%), Positives = 131/271 (48%), Gaps = 21/271 (7%)
Query: 1103 AAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDEN 1162
AA G V +E+L+K R V + T +Q A++ GH D++++L++ E+
Sbjct: 438 AAANGDVAKVEDLLK--RPDV-DVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAED 494
Query: 1163 RAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVP 1222
+ G AVH AA V++V+ + + K TPLHIA G + V+ LL
Sbjct: 495 KDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDF-- 552
Query: 1223 GTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNP 1282
P L G TPLH A ++++ +LL AG +N NG+N
Sbjct: 553 -----------GCHPSLQDSEGDTPLHDAISKKRDDILAVLLE-AGADV-TITNNNGFNA 599
Query: 1283 LHLACFGGHMSIVGLLLSRSAE--LLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEI 1339
LH A G+ S + +LLS+ ++ G T LH+A+ + H ++ E+L+ QG A +
Sbjct: 600 LHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANL 659
Query: 1340 NATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
+ + N T LH A + H +V+LL +GA
Sbjct: 660 DIQNVNQQTALHLAVERQHTQIVRLLVRAGA 690
Score = 93.9 bits (223), Expect = 6e-18
Identities = 88/327 (26%), Positives = 150/327 (45%), Gaps = 31/327 (9%)
Query: 789 DPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGA 848
D L++ V + G T +Q A ++ DI++ L++ D ++A D+DG
Sbjct: 449 DLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVD----------VEAEDKDGD 498
Query: 849 SALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTE 908
A+H+A + V++ L AD++ + + +T H G+ V+
Sbjct: 499 RAVHHAAFGD---------EGAVIEVLHRGSADLNARNKRR-QTPLHIAVNKGHLQVVKT 548
Query: 909 MIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHL 968
++ D + Q+S G TPL A + ++ LL A V + + G +ALH
Sbjct: 549 LL------DFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHH 602
Query: 969 AAEHGYLQVCDALLTNKA---FINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVL 1025
AA G LL+ ++ K +G TALHLAA+N + + + L+ NA +D+
Sbjct: 603 AALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQ 662
Query: 1026 TLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNN-YSEVVQLFLQQ 1084
+ +QT LHLA ++ +LL+ GA +D D+ G P+H A +++ S++ QL Q
Sbjct: 663 NVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQ 722
Query: 1085 HPNLVMATTKDG-NTCAHIAAIQGSVK 1110
V A + NT QG+ K
Sbjct: 723 DVGKVDAAWEPSKNTLIMGLGTQGAEK 749
Score = 77.0 bits (181), Expect = 7e-13
Identities = 55/200 (27%), Positives = 99/200 (49%), Gaps = 3/200 (1%)
Query: 1236 VPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIV 1295
V V G +G T + A+ NG+ ++++LLL V +A +++G +H A FG +++
Sbjct: 456 VDVNGQCAGHTAMQAASQNGHVDILKLLLKQ-NVDVEA-EDKDGDRAVHHAAFGDEGAVI 513
Query: 1296 GLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAK 1355
+L SA+L ++ ++ +T LHIA GH Q+V+ LL G + D G TPLH A
Sbjct: 514 EVLHRGSADL-NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAIS 572
Query: 1356 AGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFV 1415
+++ +L E+GA N + AA + + LL K + + K
Sbjct: 573 KKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDG 632
Query: 1416 YNLMVCSKNHNNIPIEEFVL 1435
Y + + +N++ + E ++
Sbjct: 633 YTALHLAALNNHVEVAELLV 652
Score = 76.2 bits (179), Expect = 1e-12
Identities = 50/154 (32%), Positives = 75/154 (48%), Gaps = 3/154 (1%)
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AA NG+ V LL V D G+ + A GH+ I+ LLL ++ ++ + D
Sbjct: 438 AAANGDVAKVEDLLKRPDV--DVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDV-EAED 494
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
+ G +H A+ ++EVL A++NA +K TPLH A GHL VVK L + G
Sbjct: 495 KDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGC 554
Query: 1371 SPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
P + + P+ A S+ +D+L LL D
Sbjct: 555 HPSLQDSEGDTPLHDAISKKRDDILAVLLEAGAD 588
Score = 73.7 bits (173), Expect = 6e-12
Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 5/172 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+R + PL +AV G+ +V+ LL L+ + GDT LH A ++ D+ +L++
Sbjct: 528 KRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSE--GDTPLHDAISKKRDDILAVLLEA 585
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIAD---NEDRTPMHLAAENGHA 177
GA V TN G LH AA G+ ++ I D ++ T +HLAA N H
Sbjct: 586 GADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHV 645
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+ ELL + A++ + + T +H+A H +L + G L + +K
Sbjct: 646 EVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDK 697
Score = 71.3 bits (167), Expect = 3e-11
Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 3/150 (2%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQT 133
G++ V E+L +A+ L A T LH+A + + + + L+D+G + G T
Sbjct: 507 GDEGAVIEVLHRGSAD-LNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDT 565
Query: 134 PLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKAS--I 191
PLH A ++ + ++ A+ I +N +H AA G+ + + +L K +
Sbjct: 566 PLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIV 625
Query: 192 FERTKDGSTLMHIASLNGHADCAMMLFKKG 221
E+ DG T +H+A+LN H + A +L +G
Sbjct: 626 DEKKDDGYTALHLAALNNHVEVAELLVHQG 655
Score = 69.7 bits (163), Expect = 1e-10
Identities = 73/268 (27%), Positives = 118/268 (44%), Gaps = 21/268 (7%)
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK 1195
++ AA G A V +L R + AG TA+ A+++GH ++L ++ N +
Sbjct: 436 VKAAANGDVAKVEDLLKRPDVDVNGQC-AGHTAMQAASQNGHVDILKLLLKQNVDVEAED 494
Query: 1196 KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNG 1255
K G +H AA+ G V E+L G+ A + TPLH+A G
Sbjct: 495 KDGDRAVHHAAF-GDEGAVIEVLHR--GSADLNARN----------KRRQTPLHIAVNKG 541
Query: 1256 NENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKT 1315
+ VV+ LL+ G +E G PLH A I+ +LL A++ T+ +G
Sbjct: 542 HLQVVKTLLDF-GCHPSLQDSE-GDTPLHDAISKKRDDILAVLLEAGADVT-ITNNNGFN 598
Query: 1316 GLHIASTHGHYQMVEVLLGQGAE---INATDKNGWTPLHCAAKAGHLNVVKLLCESGASP 1372
LH A+ G+ + VLL + ++ +G+T LH AA H+ V +LL G +
Sbjct: 599 ALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNAN 658
Query: 1373 KSETNLN-CAPIWFAASENHNDVLEYLL 1399
N+N + A H ++ L+
Sbjct: 659 LDIQNVNQQTALHLAVERQHTQIVRLLV 686
Score = 63.3 bits (147), Expect = 9e-09
Identities = 43/127 (33%), Positives = 63/127 (49%), Gaps = 2/127 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A++ GHV I+ LL++ V+ D A+H A + AV+E L AD+
Sbjct: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ R K+R+TPLHIA + LL G P+ +G TP+H A L +
Sbjct: 524 NAR-NKRRQTPLHIAVN-KGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAV 581
Query: 783 LLEDGGD 789
LLE G D
Sbjct: 582 LLEAGAD 588
Score = 57.6 bits (133), Expect = 4e-07
Identities = 63/235 (26%), Positives = 107/235 (45%), Gaps = 27/235 (11%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGES-VDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
DG R++H AA +G G + +L +G + ++ T LHIAV VV+TLL +G
Sbjct: 496 DGDRAVHHAA-FGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGC 554
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
++ + +TPLH A D A +LL++GA +G +H AA GN + +
Sbjct: 555 HPSLQ-DSEGDTPLHDAISKKRDDILA-VLLEAGADVTITNNNGFNALHHAALRGNPSAM 612
Query: 781 VLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFI 840
+LL L + + G T L +A + ++ L+ H+G A +
Sbjct: 613 RVLL----SKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLV-----HQG----NANL 659
Query: 841 DAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFH 895
D + + +ALH A + Q+V+ L+ GA + +Q + + +T H
Sbjct: 660 DIQNVNQQTALHLA---------VERQHTQIVRLLVRAGAKLDIQDK-DGDTPLH 704
Score = 56.0 bits (129), Expect = 1e-06
Identities = 42/158 (26%), Positives = 72/158 (45%), Gaps = 3/158 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G + A + G+ +++ LL ++A GD A+H AA + + +L A
Sbjct: 464 GHTAMQAASQNGHVDILKLLLKQNV--DVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSA 521
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
++A N QTPLHIA +G +VK + ++ D+E TP+H A I+ +
Sbjct: 522 DLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAV 581
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L + A + +G +H A+L G+ +L K
Sbjct: 582 LLEA-GADVTITNNNGFNALHHAALRGNPSAMRVLLSK 618
Score = 53.2 bits (122), Expect = 1e-05
Identities = 32/132 (24%), Positives = 62/132 (46%), Gaps = 1/132 (0%)
Query: 97 AGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRAN 156
AG TA+ A++ VD+ ++L+ V+A + G +H AA + +++ + A+
Sbjct: 463 AGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSAD 522
Query: 157 AAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMM 216
+ +TP+H+A GH +++ L D F + +G T +H A D +
Sbjct: 523 LNARNKRRQTPLHIAVNKGHLQVVKTLLD-FGCHPSLQDSEGDTPLHDAISKKRDDILAV 581
Query: 217 LFKKGVYLHMPN 228
L + G + + N
Sbjct: 582 LLEAGADVTITN 593
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/191 (26%), Positives = 79/191 (41%), Gaps = 17/191 (8%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H A GH+ ++ TLL G + ++ T LH A+ + ++ LL GADV I
Sbjct: 534 LHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITN 593
Query: 727 GKQRETPLHIAAR-IPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
H A R P + L L ++ +DG T +H+AA ++ LL+
Sbjct: 594 NNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVH 653
Query: 786 DGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDE 845
G L V +T L +A IVR L+ + A +D D+
Sbjct: 654 QGNANLD------IQNVNQQTALHLAVERQHTQIVRLLVR----------AGAKLDIQDK 697
Query: 846 DGASALHYACK 856
DG + LH A +
Sbjct: 698 DGDTPLHEALR 708
Score = 50.4 bits (115), Expect = 7e-05
Identities = 39/123 (31%), Positives = 63/123 (51%), Gaps = 6/123 (4%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGES---VDVTTNDNYTALHIAVESCKPAVVETLLGY 718
+G ++H AA G+ + LL K VD +D YTALH+A + V E L+
Sbjct: 595 NGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQ 654
Query: 719 G-ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
G A++ I+ Q +T LH+A + +L+++GA + +DG TP+H A + L
Sbjct: 655 GNANLDIQNVNQ-QTALHLAVE-RQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTL 712
Query: 778 ATL 780
+ L
Sbjct: 713 SQL 715
Score = 50.4 bits (115), Expect = 7e-05
Identities = 38/114 (33%), Positives = 52/114 (45%), Gaps = 2/114 (1%)
Query: 74 GNQSMVRELLSAQTAEQL-KATTPAGDTALHLAARRRDVDMARILVDYG-AVVDATNGAG 131
GN S +R LLS + G TALHLAA V++A +LV G A +D N
Sbjct: 607 GNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQ 666
Query: 132 QTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
QT LH+A +V+ A I D + TP+H A + + + L D
Sbjct: 667 QTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQD 720
Score = 50.4 bits (115), Expect = 7e-05
Identities = 30/82 (36%), Positives = 45/82 (54%), Gaps = 2/82 (2%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGE-SVDVTTNDNYTALHIAVESCKPAVVETLLG 717
K DG ++H AA HV + L+ +G ++D+ + TALH+AVE +V L+
Sbjct: 628 KKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVR 687
Query: 718 YGADVHIRGGKQRETPLHIAAR 739
GA + I+ K +TPLH A R
Sbjct: 688 AGAKLDIQ-DKDGDTPLHEALR 708
>BC110581-1|AAI10582.1| 1006|Homo sapiens mindbomb homolog 1
(Drosophila) protein.
Length = 1006
Score = 109 bits (261), Expect = 1e-22
Identities = 82/271 (30%), Positives = 131/271 (48%), Gaps = 21/271 (7%)
Query: 1103 AAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDEN 1162
AA G V +E+L+K R V + T +Q A++ GH D++++L++ E+
Sbjct: 438 AAANGDVAKVEDLLK--RPDV-DVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAED 494
Query: 1163 RAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVP 1222
+ G AVH AA V++V+ + + K TPLHIA G + V+ LL
Sbjct: 495 KDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDF-- 552
Query: 1223 GTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNP 1282
P L G TPLH A ++++ +LL AG +N NG+N
Sbjct: 553 -----------GCHPSLQDSEGDTPLHDAISKKRDDILAVLLE-AGADV-TITNNNGFNA 599
Query: 1283 LHLACFGGHMSIVGLLLSRSAE--LLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEI 1339
LH A G+ S + +LLS+ ++ G T LH+A+ + H ++ E+L+ QG A +
Sbjct: 600 LHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANL 659
Query: 1340 NATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
+ + N T LH A + H +V+LL +GA
Sbjct: 660 DIQNVNQQTALHLAVERQHTQIVRLLVRAGA 690
Score = 93.9 bits (223), Expect = 6e-18
Identities = 88/327 (26%), Positives = 150/327 (45%), Gaps = 31/327 (9%)
Query: 789 DPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGA 848
D L++ V + G T +Q A ++ DI++ L++ D ++A D+DG
Sbjct: 449 DLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVD----------VEAEDKDGD 498
Query: 849 SALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTE 908
A+H+A + V++ L AD++ + + +T H G+ V+
Sbjct: 499 RAVHHAAFGD---------EGAVIEVLHRGSADLNARNKRR-QTPLHIAVNKGHLQVVKT 548
Query: 909 MIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHL 968
++ D + Q+S G TPL A + ++ LL A V + + G +ALH
Sbjct: 549 LL------DFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHH 602
Query: 969 AAEHGYLQVCDALLTNKA---FINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVL 1025
AA G LL+ ++ K +G TALHLAA+N + + + L+ NA +D+
Sbjct: 603 AALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQ 662
Query: 1026 TLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNN-YSEVVQLFLQQ 1084
+ +QT LHLA ++ +LL+ GA +D D+ G P+H A +++ S++ QL Q
Sbjct: 663 NVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQ 722
Query: 1085 HPNLVMATTKDG-NTCAHIAAIQGSVK 1110
V A + NT QG+ K
Sbjct: 723 DVGKVDAAWEPSKNTLIMGLGTQGAEK 749
Score = 77.0 bits (181), Expect = 7e-13
Identities = 55/200 (27%), Positives = 99/200 (49%), Gaps = 3/200 (1%)
Query: 1236 VPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIV 1295
V V G +G T + A+ NG+ ++++LLL V +A +++G +H A FG +++
Sbjct: 456 VDVNGQCAGHTAMQAASQNGHVDILKLLLKQ-NVDVEA-EDKDGDRAVHHAAFGDEGAVI 513
Query: 1296 GLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAK 1355
+L SA+L ++ ++ +T LHIA GH Q+V+ LL G + D G TPLH A
Sbjct: 514 EVLHRGSADL-NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAIS 572
Query: 1356 AGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFV 1415
+++ +L E+GA N + AA + + LL K + + K
Sbjct: 573 KKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDG 632
Query: 1416 YNLMVCSKNHNNIPIEEFVL 1435
Y + + +N++ + E ++
Sbjct: 633 YTALHLAALNNHVEVAELLV 652
Score = 76.2 bits (179), Expect = 1e-12
Identities = 50/154 (32%), Positives = 75/154 (48%), Gaps = 3/154 (1%)
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AA NG+ V LL V D G+ + A GH+ I+ LLL ++ ++ + D
Sbjct: 438 AAANGDVAKVEDLLKRPDV--DVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDV-EAED 494
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
+ G +H A+ ++EVL A++NA +K TPLH A GHL VVK L + G
Sbjct: 495 KDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGC 554
Query: 1371 SPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
P + + P+ A S+ +D+L LL D
Sbjct: 555 HPSLQDSEGDTPLHDAISKKRDDILAVLLEAGAD 588
Score = 73.7 bits (173), Expect = 6e-12
Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 5/172 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+R + PL +AV G+ +V+ LL L+ + GDT LH A ++ D+ +L++
Sbjct: 528 KRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSE--GDTPLHDAISKKRDDILAVLLEA 585
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIAD---NEDRTPMHLAAENGHA 177
GA V TN G LH AA G+ ++ I D ++ T +HLAA N H
Sbjct: 586 GADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHV 645
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+ ELL + A++ + + T +H+A H +L + G L + +K
Sbjct: 646 EVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDK 697
Score = 71.3 bits (167), Expect = 3e-11
Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 3/150 (2%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQT 133
G++ V E+L +A+ L A T LH+A + + + + L+D+G + G T
Sbjct: 507 GDEGAVIEVLHRGSAD-LNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDT 565
Query: 134 PLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKAS--I 191
PLH A ++ + ++ A+ I +N +H AA G+ + + +L K +
Sbjct: 566 PLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIV 625
Query: 192 FERTKDGSTLMHIASLNGHADCAMMLFKKG 221
E+ DG T +H+A+LN H + A +L +G
Sbjct: 626 DEKKDDGYTALHLAALNNHVEVAELLVHQG 655
Score = 69.7 bits (163), Expect = 1e-10
Identities = 73/268 (27%), Positives = 118/268 (44%), Gaps = 21/268 (7%)
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK 1195
++ AA G A V +L R + AG TA+ A+++GH ++L ++ N +
Sbjct: 436 VKAAANGDVAKVEDLLKRPDVDVNGQC-AGHTAMQAASQNGHVDILKLLLKQNVDVEAED 494
Query: 1196 KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNG 1255
K G +H AA+ G V E+L G+ A + TPLH+A G
Sbjct: 495 KDGDRAVHHAAF-GDEGAVIEVLHR--GSADLNARN----------KRRQTPLHIAVNKG 541
Query: 1256 NENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKT 1315
+ VV+ LL+ G +E G PLH A I+ +LL A++ T+ +G
Sbjct: 542 HLQVVKTLLDF-GCHPSLQDSE-GDTPLHDAISKKRDDILAVLLEAGADVT-ITNNNGFN 598
Query: 1316 GLHIASTHGHYQMVEVLLGQGAE---INATDKNGWTPLHCAAKAGHLNVVKLLCESGASP 1372
LH A+ G+ + VLL + ++ +G+T LH AA H+ V +LL G +
Sbjct: 599 ALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNAN 658
Query: 1373 KSETNLN-CAPIWFAASENHNDVLEYLL 1399
N+N + A H ++ L+
Sbjct: 659 LDIQNVNQQTALHLAVERQHTQIVRLLV 686
Score = 63.3 bits (147), Expect = 9e-09
Identities = 43/127 (33%), Positives = 63/127 (49%), Gaps = 2/127 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A++ GHV I+ LL++ V+ D A+H A + AV+E L AD+
Sbjct: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ R K+R+TPLHIA + LL G P+ +G TP+H A L +
Sbjct: 524 NAR-NKRRQTPLHIAVN-KGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAV 581
Query: 783 LLEDGGD 789
LLE G D
Sbjct: 582 LLEAGAD 588
Score = 57.6 bits (133), Expect = 4e-07
Identities = 63/235 (26%), Positives = 107/235 (45%), Gaps = 27/235 (11%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGES-VDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
DG R++H AA +G G + +L +G + ++ T LHIAV VV+TLL +G
Sbjct: 496 DGDRAVHHAA-FGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGC 554
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
++ + +TPLH A D A +LL++GA +G +H AA GN + +
Sbjct: 555 HPSLQ-DSEGDTPLHDAISKKRDDILA-VLLEAGADVTITNNNGFNALHHAALRGNPSAM 612
Query: 781 VLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFI 840
+LL L + + G T L +A + ++ L+ H+G A +
Sbjct: 613 RVLL----SKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLV-----HQG----NANL 659
Query: 841 DAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFH 895
D + + +ALH A + Q+V+ L+ GA + +Q + + +T H
Sbjct: 660 DIQNVNQQTALHLA---------VERQHTQIVRLLVRAGAKLDIQDK-DGDTPLH 704
Score = 56.0 bits (129), Expect = 1e-06
Identities = 42/158 (26%), Positives = 72/158 (45%), Gaps = 3/158 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G + A + G+ +++ LL ++A GD A+H AA + + +L A
Sbjct: 464 GHTAMQAASQNGHVDILKLLLKQNV--DVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSA 521
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
++A N QTPLHIA +G +VK + ++ D+E TP+H A I+ +
Sbjct: 522 DLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAV 581
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L + A + +G +H A+L G+ +L K
Sbjct: 582 LLEA-GADVTITNNNGFNALHHAALRGNPSAMRVLLSK 618
Score = 53.2 bits (122), Expect = 1e-05
Identities = 32/132 (24%), Positives = 62/132 (46%), Gaps = 1/132 (0%)
Query: 97 AGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRAN 156
AG TA+ A++ VD+ ++L+ V+A + G +H AA + +++ + A+
Sbjct: 463 AGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSAD 522
Query: 157 AAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMM 216
+ +TP+H+A GH +++ L D F + +G T +H A D +
Sbjct: 523 LNARNKRRQTPLHIAVNKGHLQVVKTLLD-FGCHPSLQDSEGDTPLHDAISKKRDDILAV 581
Query: 217 LFKKGVYLHMPN 228
L + G + + N
Sbjct: 582 LLEAGADVTITN 593
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/191 (26%), Positives = 79/191 (41%), Gaps = 17/191 (8%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H A GH+ ++ TLL G + ++ T LH A+ + ++ LL GADV I
Sbjct: 534 LHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITN 593
Query: 727 GKQRETPLHIAAR-IPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
H A R P + L L ++ +DG T +H+AA ++ LL+
Sbjct: 594 NNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVH 653
Query: 786 DGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDE 845
G L V +T L +A IVR L+ + A +D D+
Sbjct: 654 QGNANLD------IQNVNQQTALHLAVERQHTQIVRLLVR----------AGAKLDIQDK 697
Query: 846 DGASALHYACK 856
DG + LH A +
Sbjct: 698 DGDTPLHEALR 708
Score = 50.4 bits (115), Expect = 7e-05
Identities = 39/123 (31%), Positives = 63/123 (51%), Gaps = 6/123 (4%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGES---VDVTTNDNYTALHIAVESCKPAVVETLLGY 718
+G ++H AA G+ + LL K VD +D YTALH+A + V E L+
Sbjct: 595 NGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQ 654
Query: 719 G-ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
G A++ I+ Q +T LH+A + +L+++GA + +DG TP+H A + L
Sbjct: 655 GNANLDIQNVNQ-QTALHLAVE-RQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTL 712
Query: 778 ATL 780
+ L
Sbjct: 713 SQL 715
Score = 50.4 bits (115), Expect = 7e-05
Identities = 38/114 (33%), Positives = 52/114 (45%), Gaps = 2/114 (1%)
Query: 74 GNQSMVRELLSAQTAEQL-KATTPAGDTALHLAARRRDVDMARILVDYG-AVVDATNGAG 131
GN S +R LLS + G TALHLAA V++A +LV G A +D N
Sbjct: 607 GNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQ 666
Query: 132 QTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
QT LH+A +V+ A I D + TP+H A + + + L D
Sbjct: 667 QTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQD 720
Score = 50.4 bits (115), Expect = 7e-05
Identities = 30/82 (36%), Positives = 45/82 (54%), Gaps = 2/82 (2%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGE-SVDVTTNDNYTALHIAVESCKPAVVETLLG 717
K DG ++H AA HV + L+ +G ++D+ + TALH+AVE +V L+
Sbjct: 628 KKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVR 687
Query: 718 YGADVHIRGGKQRETPLHIAAR 739
GA + I+ K +TPLH A R
Sbjct: 688 AGAKLDIQ-DKDGDTPLHEALR 708
>AY149908-1|AAN75493.1| 1006|Homo sapiens mind bomb protein.
Length = 1006
Score = 109 bits (261), Expect = 1e-22
Identities = 82/271 (30%), Positives = 131/271 (48%), Gaps = 21/271 (7%)
Query: 1103 AAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDEN 1162
AA G V +E+L+K R V + T +Q A++ GH D++++L++ E+
Sbjct: 438 AAANGDVAKVEDLLK--RPDV-DVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAED 494
Query: 1163 RAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVP 1222
+ G AVH AA V++V+ + + K TPLHIA G + V+ LL
Sbjct: 495 KDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDF-- 552
Query: 1223 GTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNP 1282
P L G TPLH A ++++ +LL AG +N NG+N
Sbjct: 553 -----------GCHPSLQDSEGDTPLHDAISKKRDDILAVLLE-AGADV-TITNNNGFNA 599
Query: 1283 LHLACFGGHMSIVGLLLSRSAE--LLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEI 1339
LH A G+ S + +LLS+ ++ G T LH+A+ + H ++ E+L+ QG A +
Sbjct: 600 LHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANL 659
Query: 1340 NATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
+ + N T LH A + H +V+LL +GA
Sbjct: 660 DIQNVNQQTALHLAVERQHTQIVRLLVRAGA 690
Score = 93.9 bits (223), Expect = 6e-18
Identities = 88/327 (26%), Positives = 150/327 (45%), Gaps = 31/327 (9%)
Query: 789 DPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGA 848
D L++ V + G T +Q A ++ DI++ L++ D ++A D+DG
Sbjct: 449 DLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVD----------VEAEDKDGD 498
Query: 849 SALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTE 908
A+H+A + V++ L AD++ + + +T H G+ V+
Sbjct: 499 RAVHHAAFGD---------EGAVIEVLHRGSADLNARNKRR-QTPLHIAVNKGHLQVVKT 548
Query: 909 MIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHL 968
++ D + Q+S G TPL A + ++ LL A V + + G +ALH
Sbjct: 549 LL------DFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHH 602
Query: 969 AAEHGYLQVCDALLTNKA---FINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVL 1025
AA G LL+ ++ K +G TALHLAA+N + + + L+ NA +D+
Sbjct: 603 AALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQ 662
Query: 1026 TLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNN-YSEVVQLFLQQ 1084
+ +QT LHLA ++ +LL+ GA +D D+ G P+H A +++ S++ QL Q
Sbjct: 663 NVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQ 722
Query: 1085 HPNLVMATTKDG-NTCAHIAAIQGSVK 1110
V A + NT QG+ K
Sbjct: 723 DVGKVDAAWEPSKNTLIMGLGTQGAEK 749
Score = 77.0 bits (181), Expect = 7e-13
Identities = 55/200 (27%), Positives = 99/200 (49%), Gaps = 3/200 (1%)
Query: 1236 VPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIV 1295
V V G +G T + A+ NG+ ++++LLL V +A +++G +H A FG +++
Sbjct: 456 VDVNGQCAGHTAMQAASQNGHVDILKLLLKQ-NVDVEA-EDKDGDRAVHHAAFGDEGAVI 513
Query: 1296 GLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAK 1355
+L SA+L ++ ++ +T LHIA GH Q+V+ LL G + D G TPLH A
Sbjct: 514 EVLHRGSADL-NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAIS 572
Query: 1356 AGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFV 1415
+++ +L E+GA N + AA + + LL K + + K
Sbjct: 573 KKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDG 632
Query: 1416 YNLMVCSKNHNNIPIEEFVL 1435
Y + + +N++ + E ++
Sbjct: 633 YTALHLAALNNHVEVAELLV 652
Score = 76.2 bits (179), Expect = 1e-12
Identities = 50/154 (32%), Positives = 75/154 (48%), Gaps = 3/154 (1%)
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AA NG+ V LL V D G+ + A GH+ I+ LLL ++ ++ + D
Sbjct: 438 AAANGDVAKVEDLLKRPDV--DVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDV-EAED 494
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
+ G +H A+ ++EVL A++NA +K TPLH A GHL VVK L + G
Sbjct: 495 KDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGC 554
Query: 1371 SPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
P + + P+ A S+ +D+L LL D
Sbjct: 555 HPSLQDSEGDTPLHDAISKKRDDILAVLLEAGAD 588
Score = 73.7 bits (173), Expect = 6e-12
Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 5/172 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+R + PL +AV G+ +V+ LL L+ + GDT LH A ++ D+ +L++
Sbjct: 528 KRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSE--GDTPLHDAISKKRDDILAVLLEA 585
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIAD---NEDRTPMHLAAENGHA 177
GA V TN G LH AA G+ ++ I D ++ T +HLAA N H
Sbjct: 586 GADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHV 645
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+ ELL + A++ + + T +H+A H +L + G L + +K
Sbjct: 646 EVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDK 697
Score = 71.3 bits (167), Expect = 3e-11
Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 3/150 (2%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQT 133
G++ V E+L +A+ L A T LH+A + + + + L+D+G + G T
Sbjct: 507 GDEGAVIEVLHRGSAD-LNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDT 565
Query: 134 PLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKAS--I 191
PLH A ++ + ++ A+ I +N +H AA G+ + + +L K +
Sbjct: 566 PLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIV 625
Query: 192 FERTKDGSTLMHIASLNGHADCAMMLFKKG 221
E+ DG T +H+A+LN H + A +L +G
Sbjct: 626 DEKKDDGYTALHLAALNNHVEVAELLVHQG 655
Score = 69.7 bits (163), Expect = 1e-10
Identities = 73/268 (27%), Positives = 118/268 (44%), Gaps = 21/268 (7%)
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK 1195
++ AA G A V +L R + AG TA+ A+++GH ++L ++ N +
Sbjct: 436 VKAAANGDVAKVEDLLKRPDVDVNGQC-AGHTAMQAASQNGHVDILKLLLKQNVDVEAED 494
Query: 1196 KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNG 1255
K G +H AA+ G V E+L G+ A + TPLH+A G
Sbjct: 495 KDGDRAVHHAAF-GDEGAVIEVLHR--GSADLNARN----------KRRQTPLHIAVNKG 541
Query: 1256 NENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKT 1315
+ VV+ LL+ G +E G PLH A I+ +LL A++ T+ +G
Sbjct: 542 HLQVVKTLLDF-GCHPSLQDSE-GDTPLHDAISKKRDDILAVLLEAGADVT-ITNNNGFN 598
Query: 1316 GLHIASTHGHYQMVEVLLGQGAE---INATDKNGWTPLHCAAKAGHLNVVKLLCESGASP 1372
LH A+ G+ + VLL + ++ +G+T LH AA H+ V +LL G +
Sbjct: 599 ALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNAN 658
Query: 1373 KSETNLN-CAPIWFAASENHNDVLEYLL 1399
N+N + A H ++ L+
Sbjct: 659 LDIQNVNQQTALHLAVERQHTQIVRLLV 686
Score = 63.3 bits (147), Expect = 9e-09
Identities = 43/127 (33%), Positives = 63/127 (49%), Gaps = 2/127 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A++ GHV I+ LL++ V+ D A+H A + AV+E L AD+
Sbjct: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 523
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ R K+R+TPLHIA + LL G P+ +G TP+H A L +
Sbjct: 524 NAR-NKRRQTPLHIAVN-KGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAV 581
Query: 783 LLEDGGD 789
LLE G D
Sbjct: 582 LLEAGAD 588
Score = 57.6 bits (133), Expect = 4e-07
Identities = 63/235 (26%), Positives = 107/235 (45%), Gaps = 27/235 (11%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGES-VDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
DG R++H AA +G G + +L +G + ++ T LHIAV VV+TLL +G
Sbjct: 496 DGDRAVHHAA-FGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGC 554
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
++ + +TPLH A D A +LL++GA +G +H AA GN + +
Sbjct: 555 HPSLQ-DSEGDTPLHDAISKKRDDILA-VLLEAGADVTITNNNGFNALHHAALRGNPSAM 612
Query: 781 VLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFI 840
+LL L + + G T L +A + ++ L+ H+G A +
Sbjct: 613 RVLL----SKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLV-----HQG----NANL 659
Query: 841 DAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFH 895
D + + +ALH A + Q+V+ L+ GA + +Q + + +T H
Sbjct: 660 DIQNVNQQTALHLA---------VERQHTQIVRLLVRAGAKLDIQDK-DGDTPLH 704
Score = 56.0 bits (129), Expect = 1e-06
Identities = 42/158 (26%), Positives = 72/158 (45%), Gaps = 3/158 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G + A + G+ +++ LL ++A GD A+H AA + + +L A
Sbjct: 464 GHTAMQAASQNGHVDILKLLLKQNV--DVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSA 521
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
++A N QTPLHIA +G +VK + ++ D+E TP+H A I+ +
Sbjct: 522 DLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAV 581
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L + A + +G +H A+L G+ +L K
Sbjct: 582 LLEA-GADVTITNNNGFNALHHAALRGNPSAMRVLLSK 618
Score = 53.2 bits (122), Expect = 1e-05
Identities = 32/132 (24%), Positives = 62/132 (46%), Gaps = 1/132 (0%)
Query: 97 AGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRAN 156
AG TA+ A++ VD+ ++L+ V+A + G +H AA + +++ + A+
Sbjct: 463 AGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSAD 522
Query: 157 AAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMM 216
+ +TP+H+A GH +++ L D F + +G T +H A D +
Sbjct: 523 LNARNKRRQTPLHIAVNKGHLQVVKTLLD-FGCHPSLQDSEGDTPLHDAISKKRDDILAV 581
Query: 217 LFKKGVYLHMPN 228
L + G + + N
Sbjct: 582 LLEAGADVTITN 593
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/191 (26%), Positives = 79/191 (41%), Gaps = 17/191 (8%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H A GH+ ++ TLL G + ++ T LH A+ + ++ LL GADV I
Sbjct: 534 LHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITN 593
Query: 727 GKQRETPLHIAAR-IPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
H A R P + L L ++ +DG T +H+AA ++ LL+
Sbjct: 594 NNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVH 653
Query: 786 DGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDE 845
G L V +T L +A IVR L+ + A +D D+
Sbjct: 654 QGNANLD------IQNVNQQTALHLAVERQHTQIVRLLVR----------AGAKLDIQDK 697
Query: 846 DGASALHYACK 856
DG + LH A +
Sbjct: 698 DGDTPLHEALR 708
Score = 50.4 bits (115), Expect = 7e-05
Identities = 39/123 (31%), Positives = 63/123 (51%), Gaps = 6/123 (4%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGES---VDVTTNDNYTALHIAVESCKPAVVETLLGY 718
+G ++H AA G+ + LL K VD +D YTALH+A + V E L+
Sbjct: 595 NGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQ 654
Query: 719 G-ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
G A++ I+ Q +T LH+A + +L+++GA + +DG TP+H A + L
Sbjct: 655 GNANLDIQNVNQ-QTALHLAVE-RQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTL 712
Query: 778 ATL 780
+ L
Sbjct: 713 SQL 715
Score = 50.4 bits (115), Expect = 7e-05
Identities = 38/114 (33%), Positives = 52/114 (45%), Gaps = 2/114 (1%)
Query: 74 GNQSMVRELLSAQTAEQL-KATTPAGDTALHLAARRRDVDMARILVDYG-AVVDATNGAG 131
GN S +R LLS + G TALHLAA V++A +LV G A +D N
Sbjct: 607 GNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQ 666
Query: 132 QTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
QT LH+A +V+ A I D + TP+H A + + + L D
Sbjct: 667 QTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQD 720
Score = 50.4 bits (115), Expect = 7e-05
Identities = 30/82 (36%), Positives = 45/82 (54%), Gaps = 2/82 (2%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGE-SVDVTTNDNYTALHIAVESCKPAVVETLLG 717
K DG ++H AA HV + L+ +G ++D+ + TALH+AVE +V L+
Sbjct: 628 KKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVR 687
Query: 718 YGADVHIRGGKQRETPLHIAAR 739
GA + I+ K +TPLH A R
Sbjct: 688 AGAKLDIQ-DKDGDTPLHEALR 708
>AY147849-1|AAN18023.1| 997|Homo sapiens MINDBOMB protein.
Length = 997
Score = 109 bits (261), Expect = 1e-22
Identities = 82/271 (30%), Positives = 131/271 (48%), Gaps = 21/271 (7%)
Query: 1103 AAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDEN 1162
AA G V +E+L+K R V + T +Q A++ GH D++++L++ E+
Sbjct: 429 AAANGDVAKVEDLLK--RPDV-DVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAED 485
Query: 1163 RAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVP 1222
+ G AVH AA V++V+ + + K TPLHIA G + V+ LL
Sbjct: 486 KDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDF-- 543
Query: 1223 GTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNP 1282
P L G TPLH A ++++ +LL AG +N NG+N
Sbjct: 544 -----------GCHPSLQDSEGDTPLHDAISKKRDDILAVLLE-AGADV-TITNNNGFNA 590
Query: 1283 LHLACFGGHMSIVGLLLSRSAE--LLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEI 1339
LH A G+ S + +LLS+ ++ G T LH+A+ + H ++ E+L+ QG A +
Sbjct: 591 LHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANL 650
Query: 1340 NATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
+ + N T LH A + H +V+LL +GA
Sbjct: 651 DIQNVNQQTALHLAVERQHTQIVRLLVRAGA 681
Score = 93.9 bits (223), Expect = 6e-18
Identities = 88/327 (26%), Positives = 150/327 (45%), Gaps = 31/327 (9%)
Query: 789 DPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGA 848
D L++ V + G T +Q A ++ DI++ L++ D ++A D+DG
Sbjct: 440 DLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVD----------VEAEDKDGD 489
Query: 849 SALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTE 908
A+H+A + V++ L AD++ + + +T H G+ V+
Sbjct: 490 RAVHHAAFGD---------EGAVIEVLHRGSADLNARNKRR-QTPLHIAVNKGHLQVVKT 539
Query: 909 MIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHL 968
++ D + Q+S G TPL A + ++ LL A V + + G +ALH
Sbjct: 540 LL------DFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHH 593
Query: 969 AAEHGYLQVCDALLTNKA---FINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVL 1025
AA G LL+ ++ K +G TALHLAA+N + + + L+ NA +D+
Sbjct: 594 AALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQ 653
Query: 1026 TLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNN-YSEVVQLFLQQ 1084
+ +QT LHLA ++ +LL+ GA +D D+ G P+H A +++ S++ QL Q
Sbjct: 654 NVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQ 713
Query: 1085 HPNLVMATTKDG-NTCAHIAAIQGSVK 1110
V A + NT QG+ K
Sbjct: 714 DVGKVDAAWEPSKNTLIMGLGTQGAEK 740
Score = 77.0 bits (181), Expect = 7e-13
Identities = 55/200 (27%), Positives = 99/200 (49%), Gaps = 3/200 (1%)
Query: 1236 VPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIV 1295
V V G +G T + A+ NG+ ++++LLL V +A +++G +H A FG +++
Sbjct: 447 VDVNGQCAGHTAMQAASQNGHVDILKLLLKQ-NVDVEA-EDKDGDRAVHHAAFGDEGAVI 504
Query: 1296 GLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAK 1355
+L SA+L ++ ++ +T LHIA GH Q+V+ LL G + D G TPLH A
Sbjct: 505 EVLHRGSADL-NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAIS 563
Query: 1356 AGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFV 1415
+++ +L E+GA N + AA + + LL K + + K
Sbjct: 564 KKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDG 623
Query: 1416 YNLMVCSKNHNNIPIEEFVL 1435
Y + + +N++ + E ++
Sbjct: 624 YTALHLAALNNHVEVAELLV 643
Score = 76.2 bits (179), Expect = 1e-12
Identities = 50/154 (32%), Positives = 75/154 (48%), Gaps = 3/154 (1%)
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AA NG+ V LL V D G+ + A GH+ I+ LLL ++ ++ + D
Sbjct: 429 AAANGDVAKVEDLLKRPDV--DVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDV-EAED 485
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
+ G +H A+ ++EVL A++NA +K TPLH A GHL VVK L + G
Sbjct: 486 KDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGC 545
Query: 1371 SPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
P + + P+ A S+ +D+L LL D
Sbjct: 546 HPSLQDSEGDTPLHDAISKKRDDILAVLLEAGAD 579
Score = 73.7 bits (173), Expect = 6e-12
Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 5/172 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+R + PL +AV G+ +V+ LL L+ + GDT LH A ++ D+ +L++
Sbjct: 519 KRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSE--GDTPLHDAISKKRDDILAVLLEA 576
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIAD---NEDRTPMHLAAENGHA 177
GA V TN G LH AA G+ ++ I D ++ T +HLAA N H
Sbjct: 577 GADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHV 636
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+ ELL + A++ + + T +H+A H +L + G L + +K
Sbjct: 637 EVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDK 688
Score = 71.3 bits (167), Expect = 3e-11
Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 3/150 (2%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQT 133
G++ V E+L +A+ L A T LH+A + + + + L+D+G + G T
Sbjct: 498 GDEGAVIEVLHRGSAD-LNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDT 556
Query: 134 PLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKAS--I 191
PLH A ++ + ++ A+ I +N +H AA G+ + + +L K +
Sbjct: 557 PLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIV 616
Query: 192 FERTKDGSTLMHIASLNGHADCAMMLFKKG 221
E+ DG T +H+A+LN H + A +L +G
Sbjct: 617 DEKKDDGYTALHLAALNNHVEVAELLVHQG 646
Score = 69.7 bits (163), Expect = 1e-10
Identities = 73/268 (27%), Positives = 118/268 (44%), Gaps = 21/268 (7%)
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK 1195
++ AA G A V +L R + AG TA+ A+++GH ++L ++ N +
Sbjct: 427 VKAAANGDVAKVEDLLKRPDVDVNGQC-AGHTAMQAASQNGHVDILKLLLKQNVDVEAED 485
Query: 1196 KLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNG 1255
K G +H AA+ G V E+L G+ A + TPLH+A G
Sbjct: 486 KDGDRAVHHAAF-GDEGAVIEVLHR--GSADLNARN----------KRRQTPLHIAVNKG 532
Query: 1256 NENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKT 1315
+ VV+ LL+ G +E G PLH A I+ +LL A++ T+ +G
Sbjct: 533 HLQVVKTLLDF-GCHPSLQDSE-GDTPLHDAISKKRDDILAVLLEAGADVT-ITNNNGFN 589
Query: 1316 GLHIASTHGHYQMVEVLLGQGAE---INATDKNGWTPLHCAAKAGHLNVVKLLCESGASP 1372
LH A+ G+ + VLL + ++ +G+T LH AA H+ V +LL G +
Sbjct: 590 ALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNAN 649
Query: 1373 KSETNLN-CAPIWFAASENHNDVLEYLL 1399
N+N + A H ++ L+
Sbjct: 650 LDIQNVNQQTALHLAVERQHTQIVRLLV 677
Score = 63.3 bits (147), Expect = 9e-09
Identities = 43/127 (33%), Positives = 63/127 (49%), Gaps = 2/127 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A++ GHV I+ LL++ V+ D A+H A + AV+E L AD+
Sbjct: 455 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL 514
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ R K+R+TPLHIA + LL G P+ +G TP+H A L +
Sbjct: 515 NAR-NKRRQTPLHIAVN-KGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAV 572
Query: 783 LLEDGGD 789
LLE G D
Sbjct: 573 LLEAGAD 579
Score = 57.6 bits (133), Expect = 4e-07
Identities = 63/235 (26%), Positives = 107/235 (45%), Gaps = 27/235 (11%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGES-VDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
DG R++H AA +G G + +L +G + ++ T LHIAV VV+TLL +G
Sbjct: 487 DGDRAVHHAA-FGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGC 545
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
++ + +TPLH A D A +LL++GA +G +H AA GN + +
Sbjct: 546 HPSLQ-DSEGDTPLHDAISKKRDDILA-VLLEAGADVTITNNNGFNALHHAALRGNPSAM 603
Query: 781 VLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFI 840
+LL L + + G T L +A + ++ L+ H+G A +
Sbjct: 604 RVLL----SKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLV-----HQG----NANL 650
Query: 841 DAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFH 895
D + + +ALH A + Q+V+ L+ GA + +Q + + +T H
Sbjct: 651 DIQNVNQQTALHLA---------VERQHTQIVRLLVRAGAKLDIQDK-DGDTPLH 695
Score = 56.0 bits (129), Expect = 1e-06
Identities = 42/158 (26%), Positives = 72/158 (45%), Gaps = 3/158 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G + A + G+ +++ LL ++A GD A+H AA + + +L A
Sbjct: 455 GHTAMQAASQNGHVDILKLLLKQNV--DVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSA 512
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
++A N QTPLHIA +G +VK + ++ D+E TP+H A I+ +
Sbjct: 513 DLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAV 572
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L + A + +G +H A+L G+ +L K
Sbjct: 573 LLEA-GADVTITNNNGFNALHHAALRGNPSAMRVLLSK 609
Score = 53.2 bits (122), Expect = 1e-05
Identities = 32/132 (24%), Positives = 62/132 (46%), Gaps = 1/132 (0%)
Query: 97 AGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRAN 156
AG TA+ A++ VD+ ++L+ V+A + G +H AA + +++ + A+
Sbjct: 454 AGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSAD 513
Query: 157 AAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMM 216
+ +TP+H+A GH +++ L D F + +G T +H A D +
Sbjct: 514 LNARNKRRQTPLHIAVNKGHLQVVKTLLD-FGCHPSLQDSEGDTPLHDAISKKRDDILAV 572
Query: 217 LFKKGVYLHMPN 228
L + G + + N
Sbjct: 573 LLEAGADVTITN 584
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/191 (26%), Positives = 79/191 (41%), Gaps = 17/191 (8%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H A GH+ ++ TLL G + ++ T LH A+ + ++ LL GADV I
Sbjct: 525 LHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITN 584
Query: 727 GKQRETPLHIAAR-IPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
H A R P + L L ++ +DG T +H+AA ++ LL+
Sbjct: 585 NNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVH 644
Query: 786 DGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDE 845
G L V +T L +A IVR L+ + A +D D+
Sbjct: 645 QGNANLD------IQNVNQQTALHLAVERQHTQIVRLLVR----------AGAKLDIQDK 688
Query: 846 DGASALHYACK 856
DG + LH A +
Sbjct: 689 DGDTPLHEALR 699
Score = 50.4 bits (115), Expect = 7e-05
Identities = 39/123 (31%), Positives = 63/123 (51%), Gaps = 6/123 (4%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGES---VDVTTNDNYTALHIAVESCKPAVVETLLGY 718
+G ++H AA G+ + LL K VD +D YTALH+A + V E L+
Sbjct: 586 NGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQ 645
Query: 719 G-ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
G A++ I+ Q +T LH+A + +L+++GA + +DG TP+H A + L
Sbjct: 646 GNANLDIQNVNQ-QTALHLAVE-RQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTL 703
Query: 778 ATL 780
+ L
Sbjct: 704 SQL 706
Score = 50.4 bits (115), Expect = 7e-05
Identities = 38/114 (33%), Positives = 52/114 (45%), Gaps = 2/114 (1%)
Query: 74 GNQSMVRELLSAQTAEQL-KATTPAGDTALHLAARRRDVDMARILVDYG-AVVDATNGAG 131
GN S +R LLS + G TALHLAA V++A +LV G A +D N
Sbjct: 598 GNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQ 657
Query: 132 QTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
QT LH+A +V+ A I D + TP+H A + + + L D
Sbjct: 658 QTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQD 711
Score = 50.4 bits (115), Expect = 7e-05
Identities = 30/82 (36%), Positives = 45/82 (54%), Gaps = 2/82 (2%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGE-SVDVTTNDNYTALHIAVESCKPAVVETLLG 717
K DG ++H AA HV + L+ +G ++D+ + TALH+AVE +V L+
Sbjct: 619 KKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVR 678
Query: 718 YGADVHIRGGKQRETPLHIAAR 739
GA + I+ K +TPLH A R
Sbjct: 679 AGAKLDIQ-DKDGDTPLHEALR 699
>BC016490-1|AAH16490.1| 1030|Homo sapiens MIB2 protein protein.
Length = 1030
Score = 108 bits (260), Expect = 2e-22
Identities = 79/250 (31%), Positives = 127/250 (50%), Gaps = 8/250 (3%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G T L +A + G ++L+ LL A VD+ D EG +ALH AA + LL+
Sbjct: 540 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 599
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH--LAAASGQIEVCK 1046
++ TALH+A G+ +V+ L + +++ TPLH ++A +G + +
Sbjct: 600 DAINSTQSTALHVAVQRGFLEVVRALC-ERGCDVNLPDAHSDTPLHSAISAGTGASGIVE 658
Query: 1047 LLLELGANID--ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
+L E+ NID AT+ G +H A+ ++ V+ L + LV A +DG T H+AA
Sbjct: 659 VLTEV-PNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 717
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
+ +V + L++ R V KL +PL LA + H +V +LV AG S E+
Sbjct: 718 LNNHREVAQILIREGRCDVNVRNRKL--QSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEE 775
Query: 1165 GLTAVHLAAE 1174
G TA+H+A +
Sbjct: 776 GDTALHVALQ 785
Score = 101 bits (242), Expect = 3e-20
Identities = 71/249 (28%), Positives = 123/249 (49%), Gaps = 8/249 (3%)
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
+GR+AL +AA G +++ LL +A ++ G TALH AA+ + L+
Sbjct: 539 QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLL-SAGC 597
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA--AQNNYSEVV 1078
D + + T LH+A G +EV + L E G +++ D P+H+A A S +V
Sbjct: 598 RADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIV 657
Query: 1079 QLFLQQHPNL-VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
++ L + PN+ V AT G T H A+++G + +++ R ++ A+ K + T L
Sbjct: 658 EV-LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQ-LVDAK-KEDGFTALH 714
Query: 1138 LAAEGGHADVVRVLVRAG-ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
LAA H +V ++L+R G NR + +HLA + H ++ ++ + +
Sbjct: 715 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 774
Query: 1197 LGLTPLHIA 1205
G T LH+A
Sbjct: 775 EGDTALHVA 783
Score = 96.7 bits (230), Expect = 8e-19
Identities = 72/245 (29%), Positives = 118/245 (48%), Gaps = 17/245 (6%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
T LQ+AA G +++R+L++A A + G TA+H AA V+ S +
Sbjct: 542 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 601
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLH--LA 1251
T LH+A G E VR L E V+L A S TPLH ++
Sbjct: 602 INSTQSTALHVAVQRGFLEVVRALC---------ERGCDVNLPD---AHSD-TPLHSAIS 648
Query: 1252 AYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDR 1311
A G +V +L + A+N G+ LH A GH V +L+R+ +L+ +
Sbjct: 649 AGTGASGIVEVLTEVPNIDV-TATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE 707
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
G T LH+A+ + H ++ ++L+ +G ++N ++ +PLH A + H+ +V LL ++G
Sbjct: 708 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 767
Query: 1371 SPKSE 1375
S +E
Sbjct: 768 SVNAE 772
Score = 94.3 bits (224), Expect = 4e-18
Identities = 86/292 (29%), Positives = 128/292 (43%), Gaps = 20/292 (6%)
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNK 1129
A N + + L L++ P V T G T +AA G V++I L++ R GV ++
Sbjct: 516 ALGNAARALDL-LRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQA-RAGVDLPDDE 572
Query: 1130 LNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT 1189
N T L AA G + RVL+ AG N TA+H+A + G V+ +
Sbjct: 573 GN--TALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC 630
Query: 1190 LRISSKKLGLTPLHIAAYYGQ-AETVRELLSHVPGTVKSEAPTGVSLVPVLGAES-GLTP 1247
TPLH A G A + E+L+ VP + V S G T
Sbjct: 631 DVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN------------IDVTATNSQGFTL 678
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH A+ G+ VR +L A DA E+G+ LHLA H + +L+ ++
Sbjct: 679 LHHASLKGHALAVRKILARARQLVDA-KKEDGFTALHLAALNNHREVAQILIREGRCDVN 737
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
+R ++ LH+A H +V +L+ G +NA D+ G T LH A + L
Sbjct: 738 VRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL 789
Score = 84.2 bits (199), Expect = 4e-15
Identities = 78/250 (31%), Positives = 115/250 (46%), Gaps = 22/250 (8%)
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
A +D G V +A + LD++R ++ +K G T L +AAY GQ E +R
Sbjct: 500 AQKSDPEHPGRLVVEVALGNA-ARALDLLRRRPE-QVDTKNQGRTALQVAAYLGQVELIR 557
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS 1275
LL +A GV L + G T LH AA R+LL SAG +ADA
Sbjct: 558 LLL---------QARAGVDLPD----DEGNTALHYAALGNQPEATRVLL-SAGCRADAI- 602
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH--IASTHGHYQMVEVLL 1333
N LH+A G + +V L R ++ + D H T LH I++ G +VEVL
Sbjct: 603 NSTQSTALHVAVQRGFLEVVRALCERGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLT 661
Query: 1334 G-QGAEINATDKNGWTPLHCAAKAGH-LNVVKLLCESGASPKSETNLNCAPIWFAASENH 1391
++ AT+ G+T LH A+ GH L V K+L + ++ + AA NH
Sbjct: 662 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 721
Query: 1392 NDVLEYLLHK 1401
+V + L+ +
Sbjct: 722 REVAQILIRE 731
Score = 82.6 bits (195), Expect = 1e-14
Identities = 79/275 (28%), Positives = 130/275 (47%), Gaps = 32/275 (11%)
Query: 804 GETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVK 863
G T LQ+A +++R L++ + A +D D++G +ALHYA +
Sbjct: 540 GRTALQVAAYLGQVELIRLLLQ----------ARAGVDLPDDEGNTALHYAALGNQ---- 585
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALN 923
P A R ++ A S Q+ TA H G +V+ + DV N
Sbjct: 586 -PEATRVLLSAGCRADAINSTQS-----TALHVAVQRGFLEVVRALCER--GCDV----N 633
Query: 924 RQNSIGWTPL--LIACHRGHMQLVNTLLTNHARVDVF--DVEGRSALHLAAEHGY-LQVC 978
++ TPL I+ G +V +LT +DV + +G + LH A+ G+ L V
Sbjct: 634 LPDAHSDTPLHSAISAGTGASGIVE-VLTEVPNIDVTATNSQGFTLLHHASLKGHALAVR 692
Query: 979 DALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
L + +++K +G TALHLAA+N + + + LIR+ ++V K Q+PLHLA
Sbjct: 693 KILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQ 752
Query: 1039 SGQIEVCKLLLELGANIDATDELGQKPIHAAAQNN 1073
+ + LL++ G +++A DE G +H A Q +
Sbjct: 753 QAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRH 787
Score = 77.0 bits (181), Expect = 7e-13
Identities = 99/375 (26%), Positives = 162/375 (43%), Gaps = 27/375 (7%)
Query: 995 GRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
GR + +A N L L+R +D + +T L +AA GQ+E+ +LLL+ A
Sbjct: 509 GRLVVEVALGNAARALD--LLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAG 565
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
+D D+ G +H AA N E ++ L A +T H+A +G ++V+
Sbjct: 566 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCR-ADAINSTQSTALHVAVQRGFLEVVRA 624
Query: 1115 LMKFDRTGVISARNKLNDSTPLQ--LAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHL 1171
L +R ++ + +D TPL ++A G + +V VL T N G T +H
Sbjct: 625 LC--ERGCDVNLPDAHSD-TPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHH 681
Query: 1172 AAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAP 1230
A+ GH V ++ L + K+ G T LH+AA E + L+
Sbjct: 682 ASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIRE---------- 731
Query: 1231 TGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGG 1290
G V V + +PLHLA + +V LL++ AG + A +E G LH+A
Sbjct: 732 -GRCDVNVRNRKL-QSPLHLAVQQAHVGLVPLLVD-AGCSVN-AEDEEGDTALHVALQRH 787
Query: 1291 H-MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG-QGAEINATDKNGWT 1348
+ +V L R +GL ++ V L +GA+++ T+ G +
Sbjct: 788 QLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRS 847
Query: 1349 PLHCAAKAGHLNVVK 1363
PL AA+ L ++
Sbjct: 848 PLDLAAEGRVLKALQ 862
Score = 75.4 bits (177), Expect = 2e-12
Identities = 47/152 (30%), Positives = 71/152 (46%), Gaps = 4/152 (2%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G+ L +A G ++R LL A+ L G+TALH AA + R+L+ G
Sbjct: 539 QGRTALQVAAYLGQVELIRLLLQARAGVDLP--DDEGNTALHYAALGNQPEATRVLLSAG 596
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMH--LAAENGHAAI 179
DA N T LH+A G +V+ + + D TP+H ++A G + I
Sbjct: 597 CRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGI 656
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHA 211
+E+L + + G TL+H ASL GHA
Sbjct: 657 VEVLTEVPNIDVTATNSQGFTLLHHASLKGHA 688
Score = 69.7 bits (163), Expect = 1e-10
Identities = 47/168 (27%), Positives = 79/168 (47%), Gaps = 5/168 (2%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
DL G L A R LLSA + A TALH+A +R +++ R
Sbjct: 567 DLPDDEGNTALHYAALGNQPEATRVLLSAGC--RADAINSTQSTALHVAVQRGFLEVVRA 624
Query: 117 LVDYGAVVDATNGAGQTPLH--IAAAEGDEPLVKYFYGV-RANAAIADNEDRTPMHLAAE 173
L + G V+ + TPLH I+A G +V+ V + +++ T +H A+
Sbjct: 625 LCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASL 684
Query: 174 NGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
GHA + + + + + + +DG T +H+A+LN H + A +L ++G
Sbjct: 685 KGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREG 732
Score = 68.5 bits (160), Expect = 2e-10
Identities = 83/316 (26%), Positives = 133/316 (42%), Gaps = 36/316 (11%)
Query: 731 ETPLHIAARIPDGDKC-ALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
E P + + G+ AL LL+ G T + VAA G + + LLL+
Sbjct: 506 EHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQ---- 561
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGAS 849
+ V + D G T L A P+ R L+ + DA++ ++
Sbjct: 562 --ARAGVDLPD-DEGNTALHYAALGNQPEATRVLLS----------AGCRADAINSTQST 608
Query: 850 ALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN-DVMTE 908
ALH V + +VV+ L E G DV+L H+ +T H AG + E
Sbjct: 609 ALH---------VAVQRGFLEVVRALCERGCDVNLPDAHS-DTPLHSAISAGTGASGIVE 658
Query: 909 MIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR-VDVFDVEGRSALH 967
++ + DV+ NS G+T L A +GH V +L + VD +G +ALH
Sbjct: 659 VLTEVPNIDVTAT----NSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 714
Query: 968 LAAEHGYLQVCDALL-TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
LAA + + +V L+ + +N + R ++ LHLA + LV L+ D ++
Sbjct: 715 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLV-DAGCSVNAED 773
Query: 1027 LKKQTPLHLAAASGQI 1042
+ T LH+A Q+
Sbjct: 774 EEGDTALHVALQRHQL 789
Score = 54.4 bits (125), Expect = 4e-06
Identities = 41/130 (31%), Positives = 64/130 (49%), Gaps = 5/130 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGES-VDVTTNDNYTALHIAVESCKPAVVETLLGYG-A 720
G +H A+ GH + +L + VD D +TALH+A + V + L+ G
Sbjct: 675 GFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRC 734
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
DV++R ++ ++PLH+A + L L+ +G N E+G T +HVA + L L
Sbjct: 735 DVNVR-NRKLQSPLHLAVQQAHVGLVPL-LVDAGCSVNAEDEEGDTALHVALQRHQLLPL 792
Query: 781 VLLLEDGGDP 790
V GGDP
Sbjct: 793 V-ADGAGGDP 801
Score = 50.0 bits (114), Expect = 9e-05
Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 2/120 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L++ V GN + +LL + EQ+ T G TAL +AA V++ R+L+ A VD
Sbjct: 511 LVVEVALGNAARALDLLRRRP-EQVD-TKNQGRTALQVAAYLGQVELIRLLLQARAGVDL 568
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G T LH AA + A ++ T +H+A + G ++ L ++
Sbjct: 569 PDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCER 628
Score = 48.0 bits (109), Expect = 4e-04
Identities = 36/113 (31%), Positives = 57/113 (50%), Gaps = 4/113 (3%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV-VDATNGAGQ 132
G+ VR++L A+ + + A G TALHLAA ++A+IL+ G V+ N Q
Sbjct: 686 GHALAVRKIL-ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQ 744
Query: 133 TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+PLH+A + LV + D E T +H+A + H ++ L+AD
Sbjct: 745 SPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQR-H-QLLPLVAD 795
Score = 46.0 bits (104), Expect = 0.001
Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 6/169 (3%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH--LAARRRDVDMA 114
D + L +AV+ G +VR L + + DT LH ++A +
Sbjct: 600 DAINSTQSTALHVAVQRGFLEVVRAL--CERGCDVNLPDAHSDTPLHSAISAGTGASGIV 657
Query: 115 RILVDYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAA 172
+L + + V ATN G T LH A+ +G V+ A ED T +HLAA
Sbjct: 658 EVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 717
Query: 173 ENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
N H + ++L + + + R + + +H+A H +L G
Sbjct: 718 LNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 766
Score = 43.2 bits (97), Expect = 0.010
Identities = 34/117 (29%), Positives = 47/117 (40%), Gaps = 2/117 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA G V +I LLQ VD+ ++ TALH A +P LL G
Sbjct: 540 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 599
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
Q T LH+A + + L + G N TP+H A G A+
Sbjct: 600 DAINSTQ-STALHVAVQ-RGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 654
Score = 39.5 bits (88), Expect = 0.13
Identities = 28/109 (25%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVE--SCKPAVVETLLGYGADVHI 724
+H A + HVG++ L+ G SV+ + TALH+A++ P V + G + +
Sbjct: 747 LHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQL 806
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK 773
+ + + L +A + G A L GA + G +P+ +AA+
Sbjct: 807 L-SRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE 854
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/107 (24%), Positives = 45/107 (42%), Gaps = 1/107 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
LL R E + T G+T L +A+ G +++ +LL A ++ D G T LH AA
Sbjct: 526 LLRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 584
Query: 1358 HLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
++L +G + + + A +V+ L + D
Sbjct: 585 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 631
Score = 37.9 bits (84), Expect = 0.39
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 1/76 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H AA LL G D + TALH+AV+ VV L G D
Sbjct: 572 EGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 631
Query: 722 VHIRGGKQRETPLHIA 737
V++ +TPLH A
Sbjct: 632 VNLPDA-HSDTPLHSA 646
>AL691432-4|CAM12833.1| 919|Homo sapiens mindbomb homolog 2
(Drosophila) protein.
Length = 919
Score = 108 bits (260), Expect = 2e-22
Identities = 79/250 (31%), Positives = 127/250 (50%), Gaps = 8/250 (3%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G T L +A + G ++L+ LL A VD+ D EG +ALH AA + LL+
Sbjct: 429 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 488
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH--LAAASGQIEVCK 1046
++ TALH+A G+ +V+ L + +++ TPLH ++A +G + +
Sbjct: 489 DAINSTQSTALHVAVQRGFLEVVRALC-ERGCDVNLPDAHSDTPLHSAISAGTGASGIVE 547
Query: 1047 LLLELGANID--ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
+L E+ NID AT+ G +H A+ ++ V+ L + LV A +DG T H+AA
Sbjct: 548 VLTEV-PNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 606
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
+ +V + L++ R V KL +PL LA + H +V +LV AG S E+
Sbjct: 607 LNNHREVAQILIREGRCDVNVRNRKL--QSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEE 664
Query: 1165 GLTAVHLAAE 1174
G TA+H+A +
Sbjct: 665 GDTALHVALQ 674
Score = 101 bits (242), Expect = 3e-20
Identities = 71/249 (28%), Positives = 123/249 (49%), Gaps = 8/249 (3%)
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
+GR+AL +AA G +++ LL +A ++ G TALH AA+ + L+
Sbjct: 428 QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLL-SAGC 486
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA--AQNNYSEVV 1078
D + + T LH+A G +EV + L E G +++ D P+H+A A S +V
Sbjct: 487 RADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIV 546
Query: 1079 QLFLQQHPNL-VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
++ L + PN+ V AT G T H A+++G + +++ R ++ A+ K + T L
Sbjct: 547 EV-LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQ-LVDAK-KEDGFTALH 603
Query: 1138 LAAEGGHADVVRVLVRAG-ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
LAA H +V ++L+R G NR + +HLA + H ++ ++ + +
Sbjct: 604 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 663
Query: 1197 LGLTPLHIA 1205
G T LH+A
Sbjct: 664 EGDTALHVA 672
Score = 96.7 bits (230), Expect = 8e-19
Identities = 72/245 (29%), Positives = 118/245 (48%), Gaps = 17/245 (6%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
T LQ+AA G +++R+L++A A + G TA+H AA V+ S +
Sbjct: 431 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 490
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLH--LA 1251
T LH+A G E VR L E V+L A S TPLH ++
Sbjct: 491 INSTQSTALHVAVQRGFLEVVRALC---------ERGCDVNLPD---AHSD-TPLHSAIS 537
Query: 1252 AYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDR 1311
A G +V +L + A+N G+ LH A GH V +L+R+ +L+ +
Sbjct: 538 AGTGASGIVEVLTEVPNIDV-TATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE 596
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
G T LH+A+ + H ++ ++L+ +G ++N ++ +PLH A + H+ +V LL ++G
Sbjct: 597 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 656
Query: 1371 SPKSE 1375
S +E
Sbjct: 657 SVNAE 661
Score = 94.3 bits (224), Expect = 4e-18
Identities = 86/292 (29%), Positives = 128/292 (43%), Gaps = 20/292 (6%)
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNK 1129
A N + + L L++ P V T G T +AA G V++I L++ R GV ++
Sbjct: 405 ALGNAARALDL-LRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQA-RAGVDLPDDE 461
Query: 1130 LNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT 1189
N T L AA G + RVL+ AG N TA+H+A + G V+ +
Sbjct: 462 GN--TALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC 519
Query: 1190 LRISSKKLGLTPLHIAAYYGQ-AETVRELLSHVPGTVKSEAPTGVSLVPVLGAES-GLTP 1247
TPLH A G A + E+L+ VP + V S G T
Sbjct: 520 DVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN------------IDVTATNSQGFTL 567
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH A+ G+ VR +L A DA E+G+ LHLA H + +L+ ++
Sbjct: 568 LHHASLKGHALAVRKILARARQLVDA-KKEDGFTALHLAALNNHREVAQILIREGRCDVN 626
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
+R ++ LH+A H +V +L+ G +NA D+ G T LH A + L
Sbjct: 627 VRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL 678
Score = 84.2 bits (199), Expect = 4e-15
Identities = 78/250 (31%), Positives = 115/250 (46%), Gaps = 22/250 (8%)
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
A +D G V +A + LD++R ++ +K G T L +AAY GQ E +R
Sbjct: 389 AQKSDPEHPGRLVVEVALGNA-ARALDLLRRRPE-QVDTKNQGRTALQVAAYLGQVELIR 446
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS 1275
LL +A GV L + G T LH AA R+LL SAG +ADA
Sbjct: 447 LLL---------QARAGVDLPD----DEGNTALHYAALGNQPEATRVLL-SAGCRADAI- 491
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH--IASTHGHYQMVEVLL 1333
N LH+A G + +V L R ++ + D H T LH I++ G +VEVL
Sbjct: 492 NSTQSTALHVAVQRGFLEVVRALCERGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLT 550
Query: 1334 G-QGAEINATDKNGWTPLHCAAKAGH-LNVVKLLCESGASPKSETNLNCAPIWFAASENH 1391
++ AT+ G+T LH A+ GH L V K+L + ++ + AA NH
Sbjct: 551 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 610
Query: 1392 NDVLEYLLHK 1401
+V + L+ +
Sbjct: 611 REVAQILIRE 620
Score = 82.6 bits (195), Expect = 1e-14
Identities = 79/275 (28%), Positives = 130/275 (47%), Gaps = 32/275 (11%)
Query: 804 GETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVK 863
G T LQ+A +++R L++ + A +D D++G +ALHYA +
Sbjct: 429 GRTALQVAAYLGQVELIRLLLQ----------ARAGVDLPDDEGNTALHYAALGNQ---- 474
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALN 923
P A R ++ A S Q+ TA H G +V+ + DV N
Sbjct: 475 -PEATRVLLSAGCRADAINSTQS-----TALHVAVQRGFLEVVRALCER--GCDV----N 522
Query: 924 RQNSIGWTPL--LIACHRGHMQLVNTLLTNHARVDVF--DVEGRSALHLAAEHGY-LQVC 978
++ TPL I+ G +V +LT +DV + +G + LH A+ G+ L V
Sbjct: 523 LPDAHSDTPLHSAISAGTGASGIVE-VLTEVPNIDVTATNSQGFTLLHHASLKGHALAVR 581
Query: 979 DALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
L + +++K +G TALHLAA+N + + + LIR+ ++V K Q+PLHLA
Sbjct: 582 KILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQ 641
Query: 1039 SGQIEVCKLLLELGANIDATDELGQKPIHAAAQNN 1073
+ + LL++ G +++A DE G +H A Q +
Sbjct: 642 QAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRH 676
Score = 77.0 bits (181), Expect = 7e-13
Identities = 99/375 (26%), Positives = 162/375 (43%), Gaps = 27/375 (7%)
Query: 995 GRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
GR + +A N L L+R +D + +T L +AA GQ+E+ +LLL+ A
Sbjct: 398 GRLVVEVALGNAARALD--LLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAG 454
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
+D D+ G +H AA N E ++ L A +T H+A +G ++V+
Sbjct: 455 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCR-ADAINSTQSTALHVAVQRGFLEVVRA 513
Query: 1115 LMKFDRTGVISARNKLNDSTPLQ--LAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHL 1171
L +R ++ + +D TPL ++A G + +V VL T N G T +H
Sbjct: 514 LC--ERGCDVNLPDAHSD-TPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHH 570
Query: 1172 AAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAP 1230
A+ GH V ++ L + K+ G T LH+AA E + L+
Sbjct: 571 ASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIRE---------- 620
Query: 1231 TGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGG 1290
G V V + +PLHLA + +V LL++ AG + A +E G LH+A
Sbjct: 621 -GRCDVNVRNRKL-QSPLHLAVQQAHVGLVPLLVD-AGCSVN-AEDEEGDTALHVALQRH 676
Query: 1291 H-MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG-QGAEINATDKNGWT 1348
+ +V L R +GL ++ V L +GA+++ T+ G +
Sbjct: 677 QLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRS 736
Query: 1349 PLHCAAKAGHLNVVK 1363
PL AA+ L ++
Sbjct: 737 PLDLAAEGRVLKALQ 751
Score = 75.4 bits (177), Expect = 2e-12
Identities = 47/152 (30%), Positives = 71/152 (46%), Gaps = 4/152 (2%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G+ L +A G ++R LL A+ L G+TALH AA + R+L+ G
Sbjct: 428 QGRTALQVAAYLGQVELIRLLLQARAGVDLP--DDEGNTALHYAALGNQPEATRVLLSAG 485
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMH--LAAENGHAAI 179
DA N T LH+A G +V+ + + D TP+H ++A G + I
Sbjct: 486 CRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGI 545
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHA 211
+E+L + + G TL+H ASL GHA
Sbjct: 546 VEVLTEVPNIDVTATNSQGFTLLHHASLKGHA 577
Score = 69.7 bits (163), Expect = 1e-10
Identities = 47/168 (27%), Positives = 79/168 (47%), Gaps = 5/168 (2%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
DL G L A R LLSA + A TALH+A +R +++ R
Sbjct: 456 DLPDDEGNTALHYAALGNQPEATRVLLSAGC--RADAINSTQSTALHVAVQRGFLEVVRA 513
Query: 117 LVDYGAVVDATNGAGQTPLH--IAAAEGDEPLVKYFYGV-RANAAIADNEDRTPMHLAAE 173
L + G V+ + TPLH I+A G +V+ V + +++ T +H A+
Sbjct: 514 LCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASL 573
Query: 174 NGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
GHA + + + + + + +DG T +H+A+LN H + A +L ++G
Sbjct: 574 KGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREG 621
Score = 68.5 bits (160), Expect = 2e-10
Identities = 83/316 (26%), Positives = 133/316 (42%), Gaps = 36/316 (11%)
Query: 731 ETPLHIAARIPDGDKC-ALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
E P + + G+ AL LL+ G T + VAA G + + LLL+
Sbjct: 395 EHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQ---- 450
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGAS 849
+ V + D G T L A P+ R L+ + DA++ ++
Sbjct: 451 --ARAGVDLPD-DEGNTALHYAALGNQPEATRVLLS----------AGCRADAINSTQST 497
Query: 850 ALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN-DVMTE 908
ALH V + +VV+ L E G DV+L H+ +T H AG + E
Sbjct: 498 ALH---------VAVQRGFLEVVRALCERGCDVNLPDAHS-DTPLHSAISAGTGASGIVE 547
Query: 909 MIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR-VDVFDVEGRSALH 967
++ + DV+ NS G+T L A +GH V +L + VD +G +ALH
Sbjct: 548 VLTEVPNIDVTAT----NSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 603
Query: 968 LAAEHGYLQVCDALL-TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
LAA + + +V L+ + +N + R ++ LHLA + LV L+ D ++
Sbjct: 604 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLV-DAGCSVNAED 662
Query: 1027 LKKQTPLHLAAASGQI 1042
+ T LH+A Q+
Sbjct: 663 EEGDTALHVALQRHQL 678
Score = 54.4 bits (125), Expect = 4e-06
Identities = 41/130 (31%), Positives = 64/130 (49%), Gaps = 5/130 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGES-VDVTTNDNYTALHIAVESCKPAVVETLLGYG-A 720
G +H A+ GH + +L + VD D +TALH+A + V + L+ G
Sbjct: 564 GFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRC 623
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
DV++R ++ ++PLH+A + L L+ +G N E+G T +HVA + L L
Sbjct: 624 DVNVR-NRKLQSPLHLAVQQAHVGLVPL-LVDAGCSVNAEDEEGDTALHVALQRHQLLPL 681
Query: 781 VLLLEDGGDP 790
V GGDP
Sbjct: 682 V-ADGAGGDP 690
Score = 50.0 bits (114), Expect = 9e-05
Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 2/120 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L++ V GN + +LL + EQ+ T G TAL +AA V++ R+L+ A VD
Sbjct: 400 LVVEVALGNAARALDLLRRRP-EQVD-TKNQGRTALQVAAYLGQVELIRLLLQARAGVDL 457
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G T LH AA + A ++ T +H+A + G ++ L ++
Sbjct: 458 PDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCER 517
Score = 48.0 bits (109), Expect = 4e-04
Identities = 36/113 (31%), Positives = 57/113 (50%), Gaps = 4/113 (3%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV-VDATNGAGQ 132
G+ VR++L A+ + + A G TALHLAA ++A+IL+ G V+ N Q
Sbjct: 575 GHALAVRKIL-ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQ 633
Query: 133 TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+PLH+A + LV + D E T +H+A + H ++ L+AD
Sbjct: 634 SPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQR-H-QLLPLVAD 684
Score = 46.0 bits (104), Expect = 0.001
Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 6/169 (3%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH--LAARRRDVDMA 114
D + L +AV+ G +VR L + + DT LH ++A +
Sbjct: 489 DAINSTQSTALHVAVQRGFLEVVRAL--CERGCDVNLPDAHSDTPLHSAISAGTGASGIV 546
Query: 115 RILVDYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAA 172
+L + + V ATN G T LH A+ +G V+ A ED T +HLAA
Sbjct: 547 EVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 606
Query: 173 ENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
N H + ++L + + + R + + +H+A H +L G
Sbjct: 607 LNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 655
Score = 43.2 bits (97), Expect = 0.010
Identities = 34/117 (29%), Positives = 47/117 (40%), Gaps = 2/117 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA G V +I LLQ VD+ ++ TALH A +P LL G
Sbjct: 429 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 488
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
Q T LH+A + + L + G N TP+H A G A+
Sbjct: 489 DAINSTQ-STALHVAVQ-RGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 543
Score = 39.5 bits (88), Expect = 0.13
Identities = 28/109 (25%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVE--SCKPAVVETLLGYGADVHI 724
+H A + HVG++ L+ G SV+ + TALH+A++ P V + G + +
Sbjct: 636 LHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQL 695
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK 773
+ + + L +A + G A L GA + G +P+ +AA+
Sbjct: 696 L-SRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE 743
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/107 (24%), Positives = 45/107 (42%), Gaps = 1/107 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
LL R E + T G+T L +A+ G +++ +LL A ++ D G T LH AA
Sbjct: 415 LLRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 473
Query: 1358 HLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
++L +G + + + A +V+ L + D
Sbjct: 474 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 520
Score = 37.9 bits (84), Expect = 0.39
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 1/76 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H AA LL G D + TALH+AV+ VV L G D
Sbjct: 461 EGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 520
Query: 722 VHIRGGKQRETPLHIA 737
V++ +TPLH A
Sbjct: 521 VNLPDA-HSDTPLHSA 535
>AL691432-3|CAM12832.1| 753|Homo sapiens mindbomb homolog 2
(Drosophila) protein.
Length = 753
Score = 108 bits (260), Expect = 2e-22
Identities = 79/250 (31%), Positives = 127/250 (50%), Gaps = 8/250 (3%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G T L +A + G ++L+ LL A VD+ D EG +ALH AA + LL+
Sbjct: 400 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 459
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH--LAAASGQIEVCK 1046
++ TALH+A G+ +V+ L + +++ TPLH ++A +G + +
Sbjct: 460 DAINSTQSTALHVAVQRGFLEVVRALC-ERGCDVNLPDAHSDTPLHSAISAGTGASGIVE 518
Query: 1047 LLLELGANID--ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
+L E+ NID AT+ G +H A+ ++ V+ L + LV A +DG T H+AA
Sbjct: 519 VLTEV-PNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 577
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
+ +V + L++ R V KL +PL LA + H +V +LV AG S E+
Sbjct: 578 LNNHREVAQILIREGRCDVNVRNRKL--QSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEE 635
Query: 1165 GLTAVHLAAE 1174
G TA+H+A +
Sbjct: 636 GDTALHVALQ 645
Score = 101 bits (242), Expect = 3e-20
Identities = 71/249 (28%), Positives = 123/249 (49%), Gaps = 8/249 (3%)
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
+GR+AL +AA G +++ LL +A ++ G TALH AA+ + L+
Sbjct: 399 QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLL-SAGC 457
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA--AQNNYSEVV 1078
D + + T LH+A G +EV + L E G +++ D P+H+A A S +V
Sbjct: 458 RADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIV 517
Query: 1079 QLFLQQHPNL-VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
++ L + PN+ V AT G T H A+++G + +++ R ++ A+ K + T L
Sbjct: 518 EV-LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQ-LVDAK-KEDGFTALH 574
Query: 1138 LAAEGGHADVVRVLVRAG-ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
LAA H +V ++L+R G NR + +HLA + H ++ ++ + +
Sbjct: 575 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 634
Query: 1197 LGLTPLHIA 1205
G T LH+A
Sbjct: 635 EGDTALHVA 643
Score = 96.7 bits (230), Expect = 8e-19
Identities = 72/245 (29%), Positives = 118/245 (48%), Gaps = 17/245 (6%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
T LQ+AA G +++R+L++A A + G TA+H AA V+ S +
Sbjct: 402 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 461
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLH--LA 1251
T LH+A G E VR L E V+L A S TPLH ++
Sbjct: 462 INSTQSTALHVAVQRGFLEVVRALC---------ERGCDVNLPD---AHSD-TPLHSAIS 508
Query: 1252 AYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDR 1311
A G +V +L + A+N G+ LH A GH V +L+R+ +L+ +
Sbjct: 509 AGTGASGIVEVLTEVPNIDV-TATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE 567
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
G T LH+A+ + H ++ ++L+ +G ++N ++ +PLH A + H+ +V LL ++G
Sbjct: 568 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 627
Query: 1371 SPKSE 1375
S +E
Sbjct: 628 SVNAE 632
Score = 94.3 bits (224), Expect = 4e-18
Identities = 86/292 (29%), Positives = 128/292 (43%), Gaps = 20/292 (6%)
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNK 1129
A N + + L L++ P V T G T +AA G V++I L++ R GV ++
Sbjct: 376 ALGNAARALDL-LRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQA-RAGVDLPDDE 432
Query: 1130 LNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT 1189
N T L AA G + RVL+ AG N TA+H+A + G V+ +
Sbjct: 433 GN--TALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC 490
Query: 1190 LRISSKKLGLTPLHIAAYYGQ-AETVRELLSHVPGTVKSEAPTGVSLVPVLGAES-GLTP 1247
TPLH A G A + E+L+ VP + V S G T
Sbjct: 491 DVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN------------IDVTATNSQGFTL 538
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH A+ G+ VR +L A DA E+G+ LHLA H + +L+ ++
Sbjct: 539 LHHASLKGHALAVRKILARARQLVDA-KKEDGFTALHLAALNNHREVAQILIREGRCDVN 597
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
+R ++ LH+A H +V +L+ G +NA D+ G T LH A + L
Sbjct: 598 VRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL 649
Score = 84.2 bits (199), Expect = 4e-15
Identities = 78/250 (31%), Positives = 115/250 (46%), Gaps = 22/250 (8%)
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
A +D G V +A + LD++R ++ +K G T L +AAY GQ E +R
Sbjct: 360 AQKSDPEHPGRLVVEVALGNA-ARALDLLRRRPE-QVDTKNQGRTALQVAAYLGQVELIR 417
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS 1275
LL +A GV L + G T LH AA R+LL SAG +ADA
Sbjct: 418 LLL---------QARAGVDLPD----DEGNTALHYAALGNQPEATRVLL-SAGCRADAI- 462
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH--IASTHGHYQMVEVLL 1333
N LH+A G + +V L R ++ + D H T LH I++ G +VEVL
Sbjct: 463 NSTQSTALHVAVQRGFLEVVRALCERGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLT 521
Query: 1334 G-QGAEINATDKNGWTPLHCAAKAGH-LNVVKLLCESGASPKSETNLNCAPIWFAASENH 1391
++ AT+ G+T LH A+ GH L V K+L + ++ + AA NH
Sbjct: 522 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 581
Query: 1392 NDVLEYLLHK 1401
+V + L+ +
Sbjct: 582 REVAQILIRE 591
Score = 82.6 bits (195), Expect = 1e-14
Identities = 79/275 (28%), Positives = 130/275 (47%), Gaps = 32/275 (11%)
Query: 804 GETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVK 863
G T LQ+A +++R L++ + A +D D++G +ALHYA +
Sbjct: 400 GRTALQVAAYLGQVELIRLLLQ----------ARAGVDLPDDEGNTALHYAALGNQ---- 445
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALN 923
P A R ++ A S Q+ TA H G +V+ + DV N
Sbjct: 446 -PEATRVLLSAGCRADAINSTQS-----TALHVAVQRGFLEVVRALCER--GCDV----N 493
Query: 924 RQNSIGWTPL--LIACHRGHMQLVNTLLTNHARVDVF--DVEGRSALHLAAEHGY-LQVC 978
++ TPL I+ G +V +LT +DV + +G + LH A+ G+ L V
Sbjct: 494 LPDAHSDTPLHSAISAGTGASGIVE-VLTEVPNIDVTATNSQGFTLLHHASLKGHALAVR 552
Query: 979 DALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
L + +++K +G TALHLAA+N + + + LIR+ ++V K Q+PLHLA
Sbjct: 553 KILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQ 612
Query: 1039 SGQIEVCKLLLELGANIDATDELGQKPIHAAAQNN 1073
+ + LL++ G +++A DE G +H A Q +
Sbjct: 613 QAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRH 647
Score = 77.0 bits (181), Expect = 7e-13
Identities = 99/375 (26%), Positives = 162/375 (43%), Gaps = 27/375 (7%)
Query: 995 GRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
GR + +A N L L+R +D + +T L +AA GQ+E+ +LLL+ A
Sbjct: 369 GRLVVEVALGNAARALD--LLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAG 425
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
+D D+ G +H AA N E ++ L A +T H+A +G ++V+
Sbjct: 426 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCR-ADAINSTQSTALHVAVQRGFLEVVRA 484
Query: 1115 LMKFDRTGVISARNKLNDSTPLQ--LAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHL 1171
L +R ++ + +D TPL ++A G + +V VL T N G T +H
Sbjct: 485 LC--ERGCDVNLPDAHSD-TPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHH 541
Query: 1172 AAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAP 1230
A+ GH V ++ L + K+ G T LH+AA E + L+
Sbjct: 542 ASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIRE---------- 591
Query: 1231 TGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGG 1290
G V V + +PLHLA + +V LL++ AG + A +E G LH+A
Sbjct: 592 -GRCDVNVRNRKL-QSPLHLAVQQAHVGLVPLLVD-AGCSVN-AEDEEGDTALHVALQRH 647
Query: 1291 H-MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG-QGAEINATDKNGWT 1348
+ +V L R +GL ++ V L +GA+++ T+ G +
Sbjct: 648 QLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRS 707
Query: 1349 PLHCAAKAGHLNVVK 1363
PL AA+ L ++
Sbjct: 708 PLDLAAEGRVLKALQ 722
Score = 75.4 bits (177), Expect = 2e-12
Identities = 47/152 (30%), Positives = 71/152 (46%), Gaps = 4/152 (2%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G+ L +A G ++R LL A+ L G+TALH AA + R+L+ G
Sbjct: 399 QGRTALQVAAYLGQVELIRLLLQARAGVDLP--DDEGNTALHYAALGNQPEATRVLLSAG 456
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMH--LAAENGHAAI 179
DA N T LH+A G +V+ + + D TP+H ++A G + I
Sbjct: 457 CRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGI 516
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHA 211
+E+L + + G TL+H ASL GHA
Sbjct: 517 VEVLTEVPNIDVTATNSQGFTLLHHASLKGHA 548
Score = 69.7 bits (163), Expect = 1e-10
Identities = 47/168 (27%), Positives = 79/168 (47%), Gaps = 5/168 (2%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
DL G L A R LLSA + A TALH+A +R +++ R
Sbjct: 427 DLPDDEGNTALHYAALGNQPEATRVLLSAGC--RADAINSTQSTALHVAVQRGFLEVVRA 484
Query: 117 LVDYGAVVDATNGAGQTPLH--IAAAEGDEPLVKYFYGV-RANAAIADNEDRTPMHLAAE 173
L + G V+ + TPLH I+A G +V+ V + +++ T +H A+
Sbjct: 485 LCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASL 544
Query: 174 NGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
GHA + + + + + + +DG T +H+A+LN H + A +L ++G
Sbjct: 545 KGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREG 592
Score = 68.5 bits (160), Expect = 2e-10
Identities = 83/316 (26%), Positives = 133/316 (42%), Gaps = 36/316 (11%)
Query: 731 ETPLHIAARIPDGDKC-ALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
E P + + G+ AL LL+ G T + VAA G + + LLL+
Sbjct: 366 EHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQ---- 421
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGAS 849
+ V + D G T L A P+ R L+ + DA++ ++
Sbjct: 422 --ARAGVDLPD-DEGNTALHYAALGNQPEATRVLLS----------AGCRADAINSTQST 468
Query: 850 ALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN-DVMTE 908
ALH V + +VV+ L E G DV+L H+ +T H AG + E
Sbjct: 469 ALH---------VAVQRGFLEVVRALCERGCDVNLPDAHS-DTPLHSAISAGTGASGIVE 518
Query: 909 MIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR-VDVFDVEGRSALH 967
++ + DV+ NS G+T L A +GH V +L + VD +G +ALH
Sbjct: 519 VLTEVPNIDVTAT----NSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 574
Query: 968 LAAEHGYLQVCDALL-TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
LAA + + +V L+ + +N + R ++ LHLA + LV L+ D ++
Sbjct: 575 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLV-DAGCSVNAED 633
Query: 1027 LKKQTPLHLAAASGQI 1042
+ T LH+A Q+
Sbjct: 634 EEGDTALHVALQRHQL 649
Score = 54.4 bits (125), Expect = 4e-06
Identities = 41/130 (31%), Positives = 64/130 (49%), Gaps = 5/130 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGES-VDVTTNDNYTALHIAVESCKPAVVETLLGYG-A 720
G +H A+ GH + +L + VD D +TALH+A + V + L+ G
Sbjct: 535 GFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRC 594
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
DV++R ++ ++PLH+A + L L+ +G N E+G T +HVA + L L
Sbjct: 595 DVNVR-NRKLQSPLHLAVQQAHVGLVPL-LVDAGCSVNAEDEEGDTALHVALQRHQLLPL 652
Query: 781 VLLLEDGGDP 790
V GGDP
Sbjct: 653 V-ADGAGGDP 661
Score = 50.0 bits (114), Expect = 9e-05
Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 2/120 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L++ V GN + +LL + EQ+ T G TAL +AA V++ R+L+ A VD
Sbjct: 371 LVVEVALGNAARALDLLRRRP-EQVD-TKNQGRTALQVAAYLGQVELIRLLLQARAGVDL 428
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G T LH AA + A ++ T +H+A + G ++ L ++
Sbjct: 429 PDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCER 488
Score = 48.0 bits (109), Expect = 4e-04
Identities = 36/113 (31%), Positives = 57/113 (50%), Gaps = 4/113 (3%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV-VDATNGAGQ 132
G+ VR++L A+ + + A G TALHLAA ++A+IL+ G V+ N Q
Sbjct: 546 GHALAVRKIL-ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQ 604
Query: 133 TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+PLH+A + LV + D E T +H+A + H ++ L+AD
Sbjct: 605 SPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQR-H-QLLPLVAD 655
Score = 46.0 bits (104), Expect = 0.001
Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 6/169 (3%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH--LAARRRDVDMA 114
D + L +AV+ G +VR L + + DT LH ++A +
Sbjct: 460 DAINSTQSTALHVAVQRGFLEVVRAL--CERGCDVNLPDAHSDTPLHSAISAGTGASGIV 517
Query: 115 RILVDYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAA 172
+L + + V ATN G T LH A+ +G V+ A ED T +HLAA
Sbjct: 518 EVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 577
Query: 173 ENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
N H + ++L + + + R + + +H+A H +L G
Sbjct: 578 LNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 626
Score = 43.2 bits (97), Expect = 0.010
Identities = 34/117 (29%), Positives = 47/117 (40%), Gaps = 2/117 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA G V +I LLQ VD+ ++ TALH A +P LL G
Sbjct: 400 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 459
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
Q T LH+A + + L + G N TP+H A G A+
Sbjct: 460 DAINSTQ-STALHVAVQ-RGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 514
Score = 39.5 bits (88), Expect = 0.13
Identities = 28/109 (25%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVE--SCKPAVVETLLGYGADVHI 724
+H A + HVG++ L+ G SV+ + TALH+A++ P V + G + +
Sbjct: 607 LHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQL 666
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK 773
+ + + L +A + G A L GA + G +P+ +AA+
Sbjct: 667 L-SRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE 714
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/107 (24%), Positives = 45/107 (42%), Gaps = 1/107 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
LL R E + T G+T L +A+ G +++ +LL A ++ D G T LH AA
Sbjct: 386 LLRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 444
Query: 1358 HLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
++L +G + + + A +V+ L + D
Sbjct: 445 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 491
Score = 37.9 bits (84), Expect = 0.39
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 1/76 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H AA LL G D + TALH+AV+ VV L G D
Sbjct: 432 EGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 491
Query: 722 VHIRGGKQRETPLHIA 737
V++ +TPLH A
Sbjct: 492 VNLPDA-HSDTPLHSA 506
>AL691432-2|CAM12831.1| 999|Homo sapiens mindbomb homolog 2
(Drosophila) protein.
Length = 999
Score = 108 bits (260), Expect = 2e-22
Identities = 79/250 (31%), Positives = 127/250 (50%), Gaps = 8/250 (3%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G T L +A + G ++L+ LL A VD+ D EG +ALH AA + LL+
Sbjct: 509 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 568
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH--LAAASGQIEVCK 1046
++ TALH+A G+ +V+ L + +++ TPLH ++A +G + +
Sbjct: 569 DAINSTQSTALHVAVQRGFLEVVRALC-ERGCDVNLPDAHSDTPLHSAISAGTGASGIVE 627
Query: 1047 LLLELGANID--ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
+L E+ NID AT+ G +H A+ ++ V+ L + LV A +DG T H+AA
Sbjct: 628 VLTEV-PNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 686
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
+ +V + L++ R V KL +PL LA + H +V +LV AG S E+
Sbjct: 687 LNNHREVAQILIREGRCDVNVRNRKL--QSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEE 744
Query: 1165 GLTAVHLAAE 1174
G TA+H+A +
Sbjct: 745 GDTALHVALQ 754
Score = 101 bits (242), Expect = 3e-20
Identities = 71/249 (28%), Positives = 123/249 (49%), Gaps = 8/249 (3%)
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
+GR+AL +AA G +++ LL +A ++ G TALH AA+ + L+
Sbjct: 508 QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLL-SAGC 566
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA--AQNNYSEVV 1078
D + + T LH+A G +EV + L E G +++ D P+H+A A S +V
Sbjct: 567 RADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIV 626
Query: 1079 QLFLQQHPNL-VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
++ L + PN+ V AT G T H A+++G + +++ R ++ A+ K + T L
Sbjct: 627 EV-LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQ-LVDAK-KEDGFTALH 683
Query: 1138 LAAEGGHADVVRVLVRAG-ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
LAA H +V ++L+R G NR + +HLA + H ++ ++ + +
Sbjct: 684 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 743
Query: 1197 LGLTPLHIA 1205
G T LH+A
Sbjct: 744 EGDTALHVA 752
Score = 96.7 bits (230), Expect = 8e-19
Identities = 72/245 (29%), Positives = 118/245 (48%), Gaps = 17/245 (6%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
T LQ+AA G +++R+L++A A + G TA+H AA V+ S +
Sbjct: 511 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 570
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLH--LA 1251
T LH+A G E VR L E V+L A S TPLH ++
Sbjct: 571 INSTQSTALHVAVQRGFLEVVRALC---------ERGCDVNLPD---AHSD-TPLHSAIS 617
Query: 1252 AYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDR 1311
A G +V +L + A+N G+ LH A GH V +L+R+ +L+ +
Sbjct: 618 AGTGASGIVEVLTEVPNIDV-TATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE 676
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
G T LH+A+ + H ++ ++L+ +G ++N ++ +PLH A + H+ +V LL ++G
Sbjct: 677 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 736
Query: 1371 SPKSE 1375
S +E
Sbjct: 737 SVNAE 741
Score = 94.3 bits (224), Expect = 4e-18
Identities = 86/292 (29%), Positives = 128/292 (43%), Gaps = 20/292 (6%)
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNK 1129
A N + + L L++ P V T G T +AA G V++I L++ R GV ++
Sbjct: 485 ALGNAARALDL-LRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQA-RAGVDLPDDE 541
Query: 1130 LNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT 1189
N T L AA G + RVL+ AG N TA+H+A + G V+ +
Sbjct: 542 GN--TALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC 599
Query: 1190 LRISSKKLGLTPLHIAAYYGQ-AETVRELLSHVPGTVKSEAPTGVSLVPVLGAES-GLTP 1247
TPLH A G A + E+L+ VP + V S G T
Sbjct: 600 DVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN------------IDVTATNSQGFTL 647
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH A+ G+ VR +L A DA E+G+ LHLA H + +L+ ++
Sbjct: 648 LHHASLKGHALAVRKILARARQLVDA-KKEDGFTALHLAALNNHREVAQILIREGRCDVN 706
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
+R ++ LH+A H +V +L+ G +NA D+ G T LH A + L
Sbjct: 707 VRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL 758
Score = 84.2 bits (199), Expect = 4e-15
Identities = 78/250 (31%), Positives = 115/250 (46%), Gaps = 22/250 (8%)
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
A +D G V +A + LD++R ++ +K G T L +AAY GQ E +R
Sbjct: 469 AQKSDPEHPGRLVVEVALGNA-ARALDLLRRRPE-QVDTKNQGRTALQVAAYLGQVELIR 526
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS 1275
LL +A GV L + G T LH AA R+LL SAG +ADA
Sbjct: 527 LLL---------QARAGVDLPD----DEGNTALHYAALGNQPEATRVLL-SAGCRADAI- 571
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH--IASTHGHYQMVEVLL 1333
N LH+A G + +V L R ++ + D H T LH I++ G +VEVL
Sbjct: 572 NSTQSTALHVAVQRGFLEVVRALCERGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLT 630
Query: 1334 G-QGAEINATDKNGWTPLHCAAKAGH-LNVVKLLCESGASPKSETNLNCAPIWFAASENH 1391
++ AT+ G+T LH A+ GH L V K+L + ++ + AA NH
Sbjct: 631 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 690
Query: 1392 NDVLEYLLHK 1401
+V + L+ +
Sbjct: 691 REVAQILIRE 700
Score = 82.6 bits (195), Expect = 1e-14
Identities = 79/275 (28%), Positives = 130/275 (47%), Gaps = 32/275 (11%)
Query: 804 GETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVK 863
G T LQ+A +++R L++ + A +D D++G +ALHYA +
Sbjct: 509 GRTALQVAAYLGQVELIRLLLQ----------ARAGVDLPDDEGNTALHYAALGNQ---- 554
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALN 923
P A R ++ A S Q+ TA H G +V+ + DV N
Sbjct: 555 -PEATRVLLSAGCRADAINSTQS-----TALHVAVQRGFLEVVRALCER--GCDV----N 602
Query: 924 RQNSIGWTPL--LIACHRGHMQLVNTLLTNHARVDVF--DVEGRSALHLAAEHGY-LQVC 978
++ TPL I+ G +V +LT +DV + +G + LH A+ G+ L V
Sbjct: 603 LPDAHSDTPLHSAISAGTGASGIVE-VLTEVPNIDVTATNSQGFTLLHHASLKGHALAVR 661
Query: 979 DALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
L + +++K +G TALHLAA+N + + + LIR+ ++V K Q+PLHLA
Sbjct: 662 KILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQ 721
Query: 1039 SGQIEVCKLLLELGANIDATDELGQKPIHAAAQNN 1073
+ + LL++ G +++A DE G +H A Q +
Sbjct: 722 QAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRH 756
Score = 77.0 bits (181), Expect = 7e-13
Identities = 99/375 (26%), Positives = 162/375 (43%), Gaps = 27/375 (7%)
Query: 995 GRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
GR + +A N L L+R +D + +T L +AA GQ+E+ +LLL+ A
Sbjct: 478 GRLVVEVALGNAARALD--LLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAG 534
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
+D D+ G +H AA N E ++ L A +T H+A +G ++V+
Sbjct: 535 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCR-ADAINSTQSTALHVAVQRGFLEVVRA 593
Query: 1115 LMKFDRTGVISARNKLNDSTPLQ--LAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHL 1171
L +R ++ + +D TPL ++A G + +V VL T N G T +H
Sbjct: 594 LC--ERGCDVNLPDAHSD-TPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHH 650
Query: 1172 AAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAP 1230
A+ GH V ++ L + K+ G T LH+AA E + L+
Sbjct: 651 ASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIRE---------- 700
Query: 1231 TGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGG 1290
G V V + +PLHLA + +V LL++ AG + A +E G LH+A
Sbjct: 701 -GRCDVNVRNRKL-QSPLHLAVQQAHVGLVPLLVD-AGCSVN-AEDEEGDTALHVALQRH 756
Query: 1291 H-MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG-QGAEINATDKNGWT 1348
+ +V L R +GL ++ V L +GA+++ T+ G +
Sbjct: 757 QLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRS 816
Query: 1349 PLHCAAKAGHLNVVK 1363
PL AA+ L ++
Sbjct: 817 PLDLAAEGRVLKALQ 831
Score = 75.4 bits (177), Expect = 2e-12
Identities = 47/152 (30%), Positives = 71/152 (46%), Gaps = 4/152 (2%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G+ L +A G ++R LL A+ L G+TALH AA + R+L+ G
Sbjct: 508 QGRTALQVAAYLGQVELIRLLLQARAGVDLP--DDEGNTALHYAALGNQPEATRVLLSAG 565
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMH--LAAENGHAAI 179
DA N T LH+A G +V+ + + D TP+H ++A G + I
Sbjct: 566 CRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGI 625
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHA 211
+E+L + + G TL+H ASL GHA
Sbjct: 626 VEVLTEVPNIDVTATNSQGFTLLHHASLKGHA 657
Score = 69.7 bits (163), Expect = 1e-10
Identities = 47/168 (27%), Positives = 79/168 (47%), Gaps = 5/168 (2%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
DL G L A R LLSA + A TALH+A +R +++ R
Sbjct: 536 DLPDDEGNTALHYAALGNQPEATRVLLSAGC--RADAINSTQSTALHVAVQRGFLEVVRA 593
Query: 117 LVDYGAVVDATNGAGQTPLH--IAAAEGDEPLVKYFYGV-RANAAIADNEDRTPMHLAAE 173
L + G V+ + TPLH I+A G +V+ V + +++ T +H A+
Sbjct: 594 LCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASL 653
Query: 174 NGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
GHA + + + + + + +DG T +H+A+LN H + A +L ++G
Sbjct: 654 KGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREG 701
Score = 68.5 bits (160), Expect = 2e-10
Identities = 83/316 (26%), Positives = 133/316 (42%), Gaps = 36/316 (11%)
Query: 731 ETPLHIAARIPDGDKC-ALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
E P + + G+ AL LL+ G T + VAA G + + LLL+
Sbjct: 475 EHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQ---- 530
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGAS 849
+ V + D G T L A P+ R L+ + DA++ ++
Sbjct: 531 --ARAGVDLPD-DEGNTALHYAALGNQPEATRVLLS----------AGCRADAINSTQST 577
Query: 850 ALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN-DVMTE 908
ALH V + +VV+ L E G DV+L H+ +T H AG + E
Sbjct: 578 ALH---------VAVQRGFLEVVRALCERGCDVNLPDAHS-DTPLHSAISAGTGASGIVE 627
Query: 909 MIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR-VDVFDVEGRSALH 967
++ + DV+ NS G+T L A +GH V +L + VD +G +ALH
Sbjct: 628 VLTEVPNIDVTAT----NSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 683
Query: 968 LAAEHGYLQVCDALL-TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
LAA + + +V L+ + +N + R ++ LHLA + LV L+ D ++
Sbjct: 684 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLV-DAGCSVNAED 742
Query: 1027 LKKQTPLHLAAASGQI 1042
+ T LH+A Q+
Sbjct: 743 EEGDTALHVALQRHQL 758
Score = 54.4 bits (125), Expect = 4e-06
Identities = 41/130 (31%), Positives = 64/130 (49%), Gaps = 5/130 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGES-VDVTTNDNYTALHIAVESCKPAVVETLLGYG-A 720
G +H A+ GH + +L + VD D +TALH+A + V + L+ G
Sbjct: 644 GFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRC 703
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
DV++R ++ ++PLH+A + L L+ +G N E+G T +HVA + L L
Sbjct: 704 DVNVR-NRKLQSPLHLAVQQAHVGLVPL-LVDAGCSVNAEDEEGDTALHVALQRHQLLPL 761
Query: 781 VLLLEDGGDP 790
V GGDP
Sbjct: 762 V-ADGAGGDP 770
Score = 50.0 bits (114), Expect = 9e-05
Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 2/120 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L++ V GN + +LL + EQ+ T G TAL +AA V++ R+L+ A VD
Sbjct: 480 LVVEVALGNAARALDLLRRRP-EQVD-TKNQGRTALQVAAYLGQVELIRLLLQARAGVDL 537
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G T LH AA + A ++ T +H+A + G ++ L ++
Sbjct: 538 PDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCER 597
Score = 48.0 bits (109), Expect = 4e-04
Identities = 36/113 (31%), Positives = 57/113 (50%), Gaps = 4/113 (3%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV-VDATNGAGQ 132
G+ VR++L A+ + + A G TALHLAA ++A+IL+ G V+ N Q
Sbjct: 655 GHALAVRKIL-ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQ 713
Query: 133 TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+PLH+A + LV + D E T +H+A + H ++ L+AD
Sbjct: 714 SPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQR-H-QLLPLVAD 764
Score = 46.0 bits (104), Expect = 0.001
Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 6/169 (3%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH--LAARRRDVDMA 114
D + L +AV+ G +VR L + + DT LH ++A +
Sbjct: 569 DAINSTQSTALHVAVQRGFLEVVRAL--CERGCDVNLPDAHSDTPLHSAISAGTGASGIV 626
Query: 115 RILVDYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAA 172
+L + + V ATN G T LH A+ +G V+ A ED T +HLAA
Sbjct: 627 EVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 686
Query: 173 ENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
N H + ++L + + + R + + +H+A H +L G
Sbjct: 687 LNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 735
Score = 43.2 bits (97), Expect = 0.010
Identities = 34/117 (29%), Positives = 47/117 (40%), Gaps = 2/117 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA G V +I LLQ VD+ ++ TALH A +P LL G
Sbjct: 509 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 568
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
Q T LH+A + + L + G N TP+H A G A+
Sbjct: 569 DAINSTQ-STALHVAVQ-RGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 623
Score = 39.5 bits (88), Expect = 0.13
Identities = 28/109 (25%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVE--SCKPAVVETLLGYGADVHI 724
+H A + HVG++ L+ G SV+ + TALH+A++ P V + G + +
Sbjct: 716 LHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQL 775
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK 773
+ + + L +A + G A L GA + G +P+ +AA+
Sbjct: 776 L-SRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE 823
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/107 (24%), Positives = 45/107 (42%), Gaps = 1/107 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
LL R E + T G+T L +A+ G +++ +LL A ++ D G T LH AA
Sbjct: 495 LLRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 553
Query: 1358 HLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
++L +G + + + A +V+ L + D
Sbjct: 554 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 600
Score = 37.9 bits (84), Expect = 0.39
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 1/76 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H AA LL G D + TALH+AV+ VV L G D
Sbjct: 541 EGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 600
Query: 722 VHIRGGKQRETPLHIA 737
V++ +TPLH A
Sbjct: 601 VNLPDA-HSDTPLHSA 615
>AL691432-1|CAM12830.1| 948|Homo sapiens mindbomb homolog 2
(Drosophila) protein.
Length = 948
Score = 108 bits (260), Expect = 2e-22
Identities = 79/250 (31%), Positives = 127/250 (50%), Gaps = 8/250 (3%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G T L +A + G ++L+ LL A VD+ D EG +ALH AA + LL+
Sbjct: 458 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 517
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH--LAAASGQIEVCK 1046
++ TALH+A G+ +V+ L + +++ TPLH ++A +G + +
Sbjct: 518 DAINSTQSTALHVAVQRGFLEVVRALC-ERGCDVNLPDAHSDTPLHSAISAGTGASGIVE 576
Query: 1047 LLLELGANID--ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
+L E+ NID AT+ G +H A+ ++ V+ L + LV A +DG T H+AA
Sbjct: 577 VLTEV-PNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 635
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
+ +V + L++ R V KL +PL LA + H +V +LV AG S E+
Sbjct: 636 LNNHREVAQILIREGRCDVNVRNRKL--QSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEE 693
Query: 1165 GLTAVHLAAE 1174
G TA+H+A +
Sbjct: 694 GDTALHVALQ 703
Score = 101 bits (242), Expect = 3e-20
Identities = 71/249 (28%), Positives = 123/249 (49%), Gaps = 8/249 (3%)
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
+GR+AL +AA G +++ LL +A ++ G TALH AA+ + L+
Sbjct: 457 QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLL-SAGC 515
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA--AQNNYSEVV 1078
D + + T LH+A G +EV + L E G +++ D P+H+A A S +V
Sbjct: 516 RADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIV 575
Query: 1079 QLFLQQHPNL-VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
++ L + PN+ V AT G T H A+++G + +++ R ++ A+ K + T L
Sbjct: 576 EV-LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQ-LVDAK-KEDGFTALH 632
Query: 1138 LAAEGGHADVVRVLVRAG-ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
LAA H +V ++L+R G NR + +HLA + H ++ ++ + +
Sbjct: 633 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 692
Query: 1197 LGLTPLHIA 1205
G T LH+A
Sbjct: 693 EGDTALHVA 701
Score = 96.7 bits (230), Expect = 8e-19
Identities = 72/245 (29%), Positives = 118/245 (48%), Gaps = 17/245 (6%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
T LQ+AA G +++R+L++A A + G TA+H AA V+ S +
Sbjct: 460 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 519
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLH--LA 1251
T LH+A G E VR L E V+L A S TPLH ++
Sbjct: 520 INSTQSTALHVAVQRGFLEVVRALC---------ERGCDVNLPD---AHSD-TPLHSAIS 566
Query: 1252 AYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDR 1311
A G +V +L + A+N G+ LH A GH V +L+R+ +L+ +
Sbjct: 567 AGTGASGIVEVLTEVPNIDV-TATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE 625
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
G T LH+A+ + H ++ ++L+ +G ++N ++ +PLH A + H+ +V LL ++G
Sbjct: 626 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 685
Query: 1371 SPKSE 1375
S +E
Sbjct: 686 SVNAE 690
Score = 94.3 bits (224), Expect = 4e-18
Identities = 86/292 (29%), Positives = 128/292 (43%), Gaps = 20/292 (6%)
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNK 1129
A N + + L L++ P V T G T +AA G V++I L++ R GV ++
Sbjct: 434 ALGNAARALDL-LRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQA-RAGVDLPDDE 490
Query: 1130 LNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT 1189
N T L AA G + RVL+ AG N TA+H+A + G V+ +
Sbjct: 491 GN--TALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC 548
Query: 1190 LRISSKKLGLTPLHIAAYYGQ-AETVRELLSHVPGTVKSEAPTGVSLVPVLGAES-GLTP 1247
TPLH A G A + E+L+ VP + V S G T
Sbjct: 549 DVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN------------IDVTATNSQGFTL 596
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH A+ G+ VR +L A DA E+G+ LHLA H + +L+ ++
Sbjct: 597 LHHASLKGHALAVRKILARARQLVDA-KKEDGFTALHLAALNNHREVAQILIREGRCDVN 655
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
+R ++ LH+A H +V +L+ G +NA D+ G T LH A + L
Sbjct: 656 VRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL 707
Score = 84.2 bits (199), Expect = 4e-15
Identities = 78/250 (31%), Positives = 115/250 (46%), Gaps = 22/250 (8%)
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
A +D G V +A + LD++R ++ +K G T L +AAY GQ E +R
Sbjct: 418 AQKSDPEHPGRLVVEVALGNA-ARALDLLRRRPE-QVDTKNQGRTALQVAAYLGQVELIR 475
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS 1275
LL +A GV L + G T LH AA R+LL SAG +ADA
Sbjct: 476 LLL---------QARAGVDLPD----DEGNTALHYAALGNQPEATRVLL-SAGCRADAI- 520
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH--IASTHGHYQMVEVLL 1333
N LH+A G + +V L R ++ + D H T LH I++ G +VEVL
Sbjct: 521 NSTQSTALHVAVQRGFLEVVRALCERGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLT 579
Query: 1334 G-QGAEINATDKNGWTPLHCAAKAGH-LNVVKLLCESGASPKSETNLNCAPIWFAASENH 1391
++ AT+ G+T LH A+ GH L V K+L + ++ + AA NH
Sbjct: 580 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 639
Query: 1392 NDVLEYLLHK 1401
+V + L+ +
Sbjct: 640 REVAQILIRE 649
Score = 82.6 bits (195), Expect = 1e-14
Identities = 79/275 (28%), Positives = 130/275 (47%), Gaps = 32/275 (11%)
Query: 804 GETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVK 863
G T LQ+A +++R L++ + A +D D++G +ALHYA +
Sbjct: 458 GRTALQVAAYLGQVELIRLLLQ----------ARAGVDLPDDEGNTALHYAALGNQ---- 503
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALN 923
P A R ++ A S Q+ TA H G +V+ + DV N
Sbjct: 504 -PEATRVLLSAGCRADAINSTQS-----TALHVAVQRGFLEVVRALCER--GCDV----N 551
Query: 924 RQNSIGWTPL--LIACHRGHMQLVNTLLTNHARVDVF--DVEGRSALHLAAEHGY-LQVC 978
++ TPL I+ G +V +LT +DV + +G + LH A+ G+ L V
Sbjct: 552 LPDAHSDTPLHSAISAGTGASGIVE-VLTEVPNIDVTATNSQGFTLLHHASLKGHALAVR 610
Query: 979 DALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
L + +++K +G TALHLAA+N + + + LIR+ ++V K Q+PLHLA
Sbjct: 611 KILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQ 670
Query: 1039 SGQIEVCKLLLELGANIDATDELGQKPIHAAAQNN 1073
+ + LL++ G +++A DE G +H A Q +
Sbjct: 671 QAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRH 705
Score = 77.0 bits (181), Expect = 7e-13
Identities = 99/375 (26%), Positives = 162/375 (43%), Gaps = 27/375 (7%)
Query: 995 GRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
GR + +A N L L+R +D + +T L +AA GQ+E+ +LLL+ A
Sbjct: 427 GRLVVEVALGNAARALD--LLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAG 483
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
+D D+ G +H AA N E ++ L A +T H+A +G ++V+
Sbjct: 484 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCR-ADAINSTQSTALHVAVQRGFLEVVRA 542
Query: 1115 LMKFDRTGVISARNKLNDSTPLQ--LAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHL 1171
L +R ++ + +D TPL ++A G + +V VL T N G T +H
Sbjct: 543 LC--ERGCDVNLPDAHSD-TPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHH 599
Query: 1172 AAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAP 1230
A+ GH V ++ L + K+ G T LH+AA E + L+
Sbjct: 600 ASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIRE---------- 649
Query: 1231 TGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGG 1290
G V V + +PLHLA + +V LL++ AG + A +E G LH+A
Sbjct: 650 -GRCDVNVRNRKL-QSPLHLAVQQAHVGLVPLLVD-AGCSVN-AEDEEGDTALHVALQRH 705
Query: 1291 H-MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG-QGAEINATDKNGWT 1348
+ +V L R +GL ++ V L +GA+++ T+ G +
Sbjct: 706 QLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRS 765
Query: 1349 PLHCAAKAGHLNVVK 1363
PL AA+ L ++
Sbjct: 766 PLDLAAEGRVLKALQ 780
Score = 75.4 bits (177), Expect = 2e-12
Identities = 47/152 (30%), Positives = 71/152 (46%), Gaps = 4/152 (2%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G+ L +A G ++R LL A+ L G+TALH AA + R+L+ G
Sbjct: 457 QGRTALQVAAYLGQVELIRLLLQARAGVDLP--DDEGNTALHYAALGNQPEATRVLLSAG 514
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMH--LAAENGHAAI 179
DA N T LH+A G +V+ + + D TP+H ++A G + I
Sbjct: 515 CRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGI 574
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHA 211
+E+L + + G TL+H ASL GHA
Sbjct: 575 VEVLTEVPNIDVTATNSQGFTLLHHASLKGHA 606
Score = 69.7 bits (163), Expect = 1e-10
Identities = 47/168 (27%), Positives = 79/168 (47%), Gaps = 5/168 (2%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
DL G L A R LLSA + A TALH+A +R +++ R
Sbjct: 485 DLPDDEGNTALHYAALGNQPEATRVLLSAGC--RADAINSTQSTALHVAVQRGFLEVVRA 542
Query: 117 LVDYGAVVDATNGAGQTPLH--IAAAEGDEPLVKYFYGV-RANAAIADNEDRTPMHLAAE 173
L + G V+ + TPLH I+A G +V+ V + +++ T +H A+
Sbjct: 543 LCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASL 602
Query: 174 NGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
GHA + + + + + + +DG T +H+A+LN H + A +L ++G
Sbjct: 603 KGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREG 650
Score = 68.5 bits (160), Expect = 2e-10
Identities = 83/316 (26%), Positives = 133/316 (42%), Gaps = 36/316 (11%)
Query: 731 ETPLHIAARIPDGDKC-ALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
E P + + G+ AL LL+ G T + VAA G + + LLL+
Sbjct: 424 EHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQ---- 479
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGAS 849
+ V + D G T L A P+ R L+ + DA++ ++
Sbjct: 480 --ARAGVDLPD-DEGNTALHYAALGNQPEATRVLLS----------AGCRADAINSTQST 526
Query: 850 ALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN-DVMTE 908
ALH V + +VV+ L E G DV+L H+ +T H AG + E
Sbjct: 527 ALH---------VAVQRGFLEVVRALCERGCDVNLPDAHS-DTPLHSAISAGTGASGIVE 576
Query: 909 MIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR-VDVFDVEGRSALH 967
++ + DV+ NS G+T L A +GH V +L + VD +G +ALH
Sbjct: 577 VLTEVPNIDVTAT----NSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 632
Query: 968 LAAEHGYLQVCDALL-TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
LAA + + +V L+ + +N + R ++ LHLA + LV L+ D ++
Sbjct: 633 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLV-DAGCSVNAED 691
Query: 1027 LKKQTPLHLAAASGQI 1042
+ T LH+A Q+
Sbjct: 692 EEGDTALHVALQRHQL 707
Score = 54.4 bits (125), Expect = 4e-06
Identities = 41/130 (31%), Positives = 64/130 (49%), Gaps = 5/130 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGES-VDVTTNDNYTALHIAVESCKPAVVETLLGYG-A 720
G +H A+ GH + +L + VD D +TALH+A + V + L+ G
Sbjct: 593 GFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRC 652
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
DV++R ++ ++PLH+A + L L+ +G N E+G T +HVA + L L
Sbjct: 653 DVNVR-NRKLQSPLHLAVQQAHVGLVPL-LVDAGCSVNAEDEEGDTALHVALQRHQLLPL 710
Query: 781 VLLLEDGGDP 790
V GGDP
Sbjct: 711 V-ADGAGGDP 719
Score = 50.0 bits (114), Expect = 9e-05
Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 2/120 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L++ V GN + +LL + EQ+ T G TAL +AA V++ R+L+ A VD
Sbjct: 429 LVVEVALGNAARALDLLRRRP-EQVD-TKNQGRTALQVAAYLGQVELIRLLLQARAGVDL 486
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G T LH AA + A ++ T +H+A + G ++ L ++
Sbjct: 487 PDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCER 546
Score = 48.0 bits (109), Expect = 4e-04
Identities = 36/113 (31%), Positives = 57/113 (50%), Gaps = 4/113 (3%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV-VDATNGAGQ 132
G+ VR++L A+ + + A G TALHLAA ++A+IL+ G V+ N Q
Sbjct: 604 GHALAVRKIL-ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQ 662
Query: 133 TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+PLH+A + LV + D E T +H+A + H ++ L+AD
Sbjct: 663 SPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQR-H-QLLPLVAD 713
Score = 46.0 bits (104), Expect = 0.001
Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 6/169 (3%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH--LAARRRDVDMA 114
D + L +AV+ G +VR L + + DT LH ++A +
Sbjct: 518 DAINSTQSTALHVAVQRGFLEVVRAL--CERGCDVNLPDAHSDTPLHSAISAGTGASGIV 575
Query: 115 RILVDYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAA 172
+L + + V ATN G T LH A+ +G V+ A ED T +HLAA
Sbjct: 576 EVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 635
Query: 173 ENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
N H + ++L + + + R + + +H+A H +L G
Sbjct: 636 LNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 684
Score = 43.2 bits (97), Expect = 0.010
Identities = 34/117 (29%), Positives = 47/117 (40%), Gaps = 2/117 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA G V +I LLQ VD+ ++ TALH A +P LL G
Sbjct: 458 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 517
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
Q T LH+A + + L + G N TP+H A G A+
Sbjct: 518 DAINSTQ-STALHVAVQ-RGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 572
Score = 39.5 bits (88), Expect = 0.13
Identities = 28/109 (25%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVE--SCKPAVVETLLGYGADVHI 724
+H A + HVG++ L+ G SV+ + TALH+A++ P V + G + +
Sbjct: 665 LHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQL 724
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK 773
+ + + L +A + G A L GA + G +P+ +AA+
Sbjct: 725 L-SRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE 772
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/107 (24%), Positives = 45/107 (42%), Gaps = 1/107 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
LL R E + T G+T L +A+ G +++ +LL A ++ D G T LH AA
Sbjct: 444 LLRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 502
Query: 1358 HLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
++L +G + + + A +V+ L + D
Sbjct: 503 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 549
Score = 37.9 bits (84), Expect = 0.39
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 1/76 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H AA LL G D + TALH+AV+ VV L G D
Sbjct: 490 EGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 549
Query: 722 VHIRGGKQRETPLHIA 737
V++ +TPLH A
Sbjct: 550 VNLPDA-HSDTPLHSA 564
>AK098785-1|BAC05413.1| 802|Homo sapiens protein ( Homo sapiens cDNA
FLJ25919 fis, clone CBR04994. ).
Length = 802
Score = 108 bits (260), Expect = 2e-22
Identities = 79/250 (31%), Positives = 127/250 (50%), Gaps = 8/250 (3%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G T L +A + G ++L+ LL A VD+ D EG +ALH AA + LL+
Sbjct: 465 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 524
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH--LAAASGQIEVCK 1046
++ TALH+A G+ +V+ L + +++ TPLH ++A +G + +
Sbjct: 525 DAINSTQSTALHVAVQRGFLEVVRALC-ERGCDVNLPDAHSDTPLHSAISAGTGASGIVE 583
Query: 1047 LLLELGANID--ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
+L E+ NID AT+ G +H A+ ++ V+ L + LV A +DG T H+AA
Sbjct: 584 VLTEV-PNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 642
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
+ +V + L++ R V KL +PL LA + H +V +LV AG S E+
Sbjct: 643 LNNHREVAQILIREGRCDVNVRNRKL--QSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEE 700
Query: 1165 GLTAVHLAAE 1174
G TA+H+A +
Sbjct: 701 GDTALHVALQ 710
Score = 101 bits (242), Expect = 3e-20
Identities = 71/249 (28%), Positives = 123/249 (49%), Gaps = 8/249 (3%)
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
+GR+AL +AA G +++ LL +A ++ G TALH AA+ + L+
Sbjct: 464 QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLL-SAGC 522
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA--AQNNYSEVV 1078
D + + T LH+A G +EV + L E G +++ D P+H+A A S +V
Sbjct: 523 RADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIV 582
Query: 1079 QLFLQQHPNL-VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
++ L + PN+ V AT G T H A+++G + +++ R ++ A+ K + T L
Sbjct: 583 EV-LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQ-LVDAK-KEDGFTALH 639
Query: 1138 LAAEGGHADVVRVLVRAG-ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
LAA H +V ++L+R G NR + +HLA + H ++ ++ + +
Sbjct: 640 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 699
Query: 1197 LGLTPLHIA 1205
G T LH+A
Sbjct: 700 EGDTALHVA 708
Score = 96.7 bits (230), Expect = 8e-19
Identities = 72/245 (29%), Positives = 118/245 (48%), Gaps = 17/245 (6%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
T LQ+AA G +++R+L++A A + G TA+H AA V+ S +
Sbjct: 467 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 526
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLH--LA 1251
T LH+A G E VR L E V+L A S TPLH ++
Sbjct: 527 INSTQSTALHVAVQRGFLEVVRALC---------ERGCDVNLPD---AHSD-TPLHSAIS 573
Query: 1252 AYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDR 1311
A G +V +L + A+N G+ LH A GH V +L+R+ +L+ +
Sbjct: 574 AGTGASGIVEVLTEVPNIDV-TATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE 632
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
G T LH+A+ + H ++ ++L+ +G ++N ++ +PLH A + H+ +V LL ++G
Sbjct: 633 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 692
Query: 1371 SPKSE 1375
S +E
Sbjct: 693 SVNAE 697
Score = 94.3 bits (224), Expect = 4e-18
Identities = 86/292 (29%), Positives = 128/292 (43%), Gaps = 20/292 (6%)
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNK 1129
A N + + L L++ P V T G T +AA G V++I L++ R GV ++
Sbjct: 441 ALGNAARALDL-LRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQA-RAGVDLPDDE 497
Query: 1130 LNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT 1189
N T L AA G + RVL+ AG N TA+H+A + G V+ +
Sbjct: 498 GN--TALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC 555
Query: 1190 LRISSKKLGLTPLHIAAYYGQ-AETVRELLSHVPGTVKSEAPTGVSLVPVLGAES-GLTP 1247
TPLH A G A + E+L+ VP + V S G T
Sbjct: 556 DVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN------------IDVTATNSQGFTL 603
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH A+ G+ VR +L A DA E+G+ LHLA H + +L+ ++
Sbjct: 604 LHHASLKGHALAVRKILARARQLVDA-KKEDGFTALHLAALNNHREVAQILIREGRCDVN 662
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
+R ++ LH+A H +V +L+ G +NA D+ G T LH A + L
Sbjct: 663 VRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL 714
Score = 84.2 bits (199), Expect = 4e-15
Identities = 78/250 (31%), Positives = 115/250 (46%), Gaps = 22/250 (8%)
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
A +D G V +A + LD++R ++ +K G T L +AAY GQ E +R
Sbjct: 425 AQKSDPEHPGRLVVEVALGNA-ARALDLLRRRPE-QVDTKNQGRTALQVAAYLGQVELIR 482
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS 1275
LL +A GV L + G T LH AA R+LL SAG +ADA
Sbjct: 483 LLL---------QARAGVDLPD----DEGNTALHYAALGNQPEATRVLL-SAGCRADAI- 527
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH--IASTHGHYQMVEVLL 1333
N LH+A G + +V L R ++ + D H T LH I++ G +VEVL
Sbjct: 528 NSTQSTALHVAVQRGFLEVVRALCERGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLT 586
Query: 1334 G-QGAEINATDKNGWTPLHCAAKAGH-LNVVKLLCESGASPKSETNLNCAPIWFAASENH 1391
++ AT+ G+T LH A+ GH L V K+L + ++ + AA NH
Sbjct: 587 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 646
Query: 1392 NDVLEYLLHK 1401
+V + L+ +
Sbjct: 647 REVAQILIRE 656
Score = 82.6 bits (195), Expect = 1e-14
Identities = 79/275 (28%), Positives = 130/275 (47%), Gaps = 32/275 (11%)
Query: 804 GETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVK 863
G T LQ+A +++R L++ + A +D D++G +ALHYA +
Sbjct: 465 GRTALQVAAYLGQVELIRLLLQ----------ARAGVDLPDDEGNTALHYAALGNQ---- 510
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALN 923
P A R ++ A S Q+ TA H G +V+ + DV N
Sbjct: 511 -PEATRVLLSAGCRADAINSTQS-----TALHVAVQRGFLEVVRALCER--GCDV----N 558
Query: 924 RQNSIGWTPL--LIACHRGHMQLVNTLLTNHARVDVF--DVEGRSALHLAAEHGY-LQVC 978
++ TPL I+ G +V +LT +DV + +G + LH A+ G+ L V
Sbjct: 559 LPDAHSDTPLHSAISAGTGASGIVE-VLTEVPNIDVTATNSQGFTLLHHASLKGHALAVR 617
Query: 979 DALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
L + +++K +G TALHLAA+N + + + LIR+ ++V K Q+PLHLA
Sbjct: 618 KILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQ 677
Query: 1039 SGQIEVCKLLLELGANIDATDELGQKPIHAAAQNN 1073
+ + LL++ G +++A DE G +H A Q +
Sbjct: 678 QAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRH 712
Score = 77.0 bits (181), Expect = 7e-13
Identities = 99/375 (26%), Positives = 162/375 (43%), Gaps = 27/375 (7%)
Query: 995 GRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
GR + +A N L L+R +D + +T L +AA GQ+E+ +LLL+ A
Sbjct: 434 GRLVVEVALGNAARALD--LLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAG 490
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
+D D+ G +H AA N E ++ L A +T H+A +G ++V+
Sbjct: 491 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCR-ADAINSTQSTALHVAVQRGFLEVVRA 549
Query: 1115 LMKFDRTGVISARNKLNDSTPLQ--LAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHL 1171
L +R ++ + +D TPL ++A G + +V VL T N G T +H
Sbjct: 550 LC--ERGCDVNLPDAHSD-TPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHH 606
Query: 1172 AAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAP 1230
A+ GH V ++ L + K+ G T LH+AA E + L+
Sbjct: 607 ASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIRE---------- 656
Query: 1231 TGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGG 1290
G V V + +PLHLA + +V LL++ AG + A +E G LH+A
Sbjct: 657 -GRCDVNVRNRKL-QSPLHLAVQQAHVGLVPLLVD-AGCSVN-AEDEEGDTALHVALQRH 712
Query: 1291 H-MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG-QGAEINATDKNGWT 1348
+ +V L R +GL ++ V L +GA+++ T+ G +
Sbjct: 713 QLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRS 772
Query: 1349 PLHCAAKAGHLNVVK 1363
PL AA+ L ++
Sbjct: 773 PLDLAAEGRVLKALQ 787
Score = 75.4 bits (177), Expect = 2e-12
Identities = 47/152 (30%), Positives = 71/152 (46%), Gaps = 4/152 (2%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G+ L +A G ++R LL A+ L G+TALH AA + R+L+ G
Sbjct: 464 QGRTALQVAAYLGQVELIRLLLQARAGVDLP--DDEGNTALHYAALGNQPEATRVLLSAG 521
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMH--LAAENGHAAI 179
DA N T LH+A G +V+ + + D TP+H ++A G + I
Sbjct: 522 CRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGI 581
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHA 211
+E+L + + G TL+H ASL GHA
Sbjct: 582 VEVLTEVPNIDVTATNSQGFTLLHHASLKGHA 613
Score = 69.7 bits (163), Expect = 1e-10
Identities = 47/168 (27%), Positives = 79/168 (47%), Gaps = 5/168 (2%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
DL G L A R LLSA + A TALH+A +R +++ R
Sbjct: 492 DLPDDEGNTALHYAALGNQPEATRVLLSAGC--RADAINSTQSTALHVAVQRGFLEVVRA 549
Query: 117 LVDYGAVVDATNGAGQTPLH--IAAAEGDEPLVKYFYGV-RANAAIADNEDRTPMHLAAE 173
L + G V+ + TPLH I+A G +V+ V + +++ T +H A+
Sbjct: 550 LCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASL 609
Query: 174 NGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
GHA + + + + + + +DG T +H+A+LN H + A +L ++G
Sbjct: 610 KGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREG 657
Score = 68.5 bits (160), Expect = 2e-10
Identities = 83/316 (26%), Positives = 133/316 (42%), Gaps = 36/316 (11%)
Query: 731 ETPLHIAARIPDGDKC-ALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
E P + + G+ AL LL+ G T + VAA G + + LLL+
Sbjct: 431 EHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQ---- 486
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGAS 849
+ V + D G T L A P+ R L+ + DA++ ++
Sbjct: 487 --ARAGVDLPD-DEGNTALHYAALGNQPEATRVLLS----------AGCRADAINSTQST 533
Query: 850 ALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN-DVMTE 908
ALH V + +VV+ L E G DV+L H+ +T H AG + E
Sbjct: 534 ALH---------VAVQRGFLEVVRALCERGCDVNLPDAHS-DTPLHSAISAGTGASGIVE 583
Query: 909 MIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR-VDVFDVEGRSALH 967
++ + DV+ NS G+T L A +GH V +L + VD +G +ALH
Sbjct: 584 VLTEVPNIDVTAT----NSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 639
Query: 968 LAAEHGYLQVCDALL-TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
LAA + + +V L+ + +N + R ++ LHLA + LV L+ D ++
Sbjct: 640 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLV-DAGCSVNAED 698
Query: 1027 LKKQTPLHLAAASGQI 1042
+ T LH+A Q+
Sbjct: 699 EEGDTALHVALQRHQL 714
Score = 54.4 bits (125), Expect = 4e-06
Identities = 41/130 (31%), Positives = 64/130 (49%), Gaps = 5/130 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGES-VDVTTNDNYTALHIAVESCKPAVVETLLGYG-A 720
G +H A+ GH + +L + VD D +TALH+A + V + L+ G
Sbjct: 600 GFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRC 659
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
DV++R ++ ++PLH+A + L L+ +G N E+G T +HVA + L L
Sbjct: 660 DVNVR-NRKLQSPLHLAVQQAHVGLVPL-LVDAGCSVNAEDEEGDTALHVALQRHQLLPL 717
Query: 781 VLLLEDGGDP 790
V GGDP
Sbjct: 718 V-ADGAGGDP 726
Score = 50.0 bits (114), Expect = 9e-05
Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 2/120 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L++ V GN + +LL + EQ+ T G TAL +AA V++ R+L+ A VD
Sbjct: 436 LVVEVALGNAARALDLLRRRP-EQVD-TKNQGRTALQVAAYLGQVELIRLLLQARAGVDL 493
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G T LH AA + A ++ T +H+A + G ++ L ++
Sbjct: 494 PDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCER 553
Score = 48.0 bits (109), Expect = 4e-04
Identities = 36/113 (31%), Positives = 57/113 (50%), Gaps = 4/113 (3%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV-VDATNGAGQ 132
G+ VR++L A+ + + A G TALHLAA ++A+IL+ G V+ N Q
Sbjct: 611 GHALAVRKIL-ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQ 669
Query: 133 TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+PLH+A + LV + D E T +H+A + H ++ L+AD
Sbjct: 670 SPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQR-H-QLLPLVAD 720
Score = 46.0 bits (104), Expect = 0.001
Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 6/169 (3%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH--LAARRRDVDMA 114
D + L +AV+ G +VR L + + DT LH ++A +
Sbjct: 525 DAINSTQSTALHVAVQRGFLEVVRAL--CERGCDVNLPDAHSDTPLHSAISAGTGASGIV 582
Query: 115 RILVDYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAA 172
+L + + V ATN G T LH A+ +G V+ A ED T +HLAA
Sbjct: 583 EVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 642
Query: 173 ENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
N H + ++L + + + R + + +H+A H +L G
Sbjct: 643 LNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 691
Score = 43.2 bits (97), Expect = 0.010
Identities = 34/117 (29%), Positives = 47/117 (40%), Gaps = 2/117 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA G V +I LLQ VD+ ++ TALH A +P LL G
Sbjct: 465 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 524
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
Q T LH+A + + L + G N TP+H A G A+
Sbjct: 525 DAINSTQ-STALHVAVQ-RGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 579
Score = 39.5 bits (88), Expect = 0.13
Identities = 28/109 (25%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVE--SCKPAVVETLLGYGADVHI 724
+H A + HVG++ L+ G SV+ + TALH+A++ P V + G + +
Sbjct: 672 LHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQL 731
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK 773
+ + + L +A + G A L GA + G +P+ +AA+
Sbjct: 732 L-SRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE 779
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/107 (24%), Positives = 45/107 (42%), Gaps = 1/107 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
LL R E + T G+T L +A+ G +++ +LL A ++ D G T LH AA
Sbjct: 451 LLRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 509
Query: 1358 HLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
++L +G + + + A +V+ L + D
Sbjct: 510 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 556
Score = 37.9 bits (84), Expect = 0.39
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 1/76 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H AA LL G D + TALH+AV+ VV L G D
Sbjct: 497 EGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 556
Query: 722 VHIRGGKQRETPLHIA 737
V++ +TPLH A
Sbjct: 557 VNLPDA-HSDTPLHSA 571
>AK097106-1|BAC04952.1| 819|Homo sapiens protein ( Homo sapiens cDNA
FLJ39787 fis, clone SPLEN2002744, weakly similar to
ANKYRIN 2. ).
Length = 819
Score = 108 bits (260), Expect = 2e-22
Identities = 79/250 (31%), Positives = 127/250 (50%), Gaps = 8/250 (3%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G T L +A + G ++L+ LL A VD+ D EG +ALH AA + LL+
Sbjct: 329 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 388
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH--LAAASGQIEVCK 1046
++ TALH+A G+ +V+ L + +++ TPLH ++A +G + +
Sbjct: 389 DAINSTQSTALHVAVQRGFLEVVRALC-ERGCDVNLPDAHSDTPLHSAISAGTGASGIVE 447
Query: 1047 LLLELGANID--ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
+L E+ NID AT+ G +H A+ ++ V+ L + LV A +DG T H+AA
Sbjct: 448 VLTEV-PNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 506
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
+ +V + L++ R V KL +PL LA + H +V +LV AG S E+
Sbjct: 507 LNNHREVAQILIREGRCDVNVRNRKL--QSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEE 564
Query: 1165 GLTAVHLAAE 1174
G TA+H+A +
Sbjct: 565 GDTALHVALQ 574
Score = 101 bits (242), Expect = 3e-20
Identities = 71/249 (28%), Positives = 123/249 (49%), Gaps = 8/249 (3%)
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
+GR+AL +AA G +++ LL +A ++ G TALH AA+ + L+
Sbjct: 328 QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLL-SAGC 386
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA--AQNNYSEVV 1078
D + + T LH+A G +EV + L E G +++ D P+H+A A S +V
Sbjct: 387 RADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIV 446
Query: 1079 QLFLQQHPNL-VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
++ L + PN+ V AT G T H A+++G + +++ R ++ A+ K + T L
Sbjct: 447 EV-LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQ-LVDAK-KEDGFTALH 503
Query: 1138 LAAEGGHADVVRVLVRAG-ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
LAA H +V ++L+R G NR + +HLA + H ++ ++ + +
Sbjct: 504 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 563
Query: 1197 LGLTPLHIA 1205
G T LH+A
Sbjct: 564 EGDTALHVA 572
Score = 96.7 bits (230), Expect = 8e-19
Identities = 72/245 (29%), Positives = 118/245 (48%), Gaps = 17/245 (6%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
T LQ+AA G +++R+L++A A + G TA+H AA V+ S +
Sbjct: 331 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 390
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLH--LA 1251
T LH+A G E VR L E V+L A S TPLH ++
Sbjct: 391 INSTQSTALHVAVQRGFLEVVRALC---------ERGCDVNLPD---AHSD-TPLHSAIS 437
Query: 1252 AYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDR 1311
A G +V +L + A+N G+ LH A GH V +L+R+ +L+ +
Sbjct: 438 AGTGASGIVEVLTEVPNIDV-TATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE 496
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
G T LH+A+ + H ++ ++L+ +G ++N ++ +PLH A + H+ +V LL ++G
Sbjct: 497 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 556
Query: 1371 SPKSE 1375
S +E
Sbjct: 557 SVNAE 561
Score = 94.3 bits (224), Expect = 4e-18
Identities = 86/292 (29%), Positives = 128/292 (43%), Gaps = 20/292 (6%)
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNK 1129
A N + + L L++ P V T G T +AA G V++I L++ R GV ++
Sbjct: 305 ALGNAARALDL-LRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQA-RAGVDLPDDE 361
Query: 1130 LNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT 1189
N T L AA G + RVL+ AG N TA+H+A + G V+ +
Sbjct: 362 GN--TALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC 419
Query: 1190 LRISSKKLGLTPLHIAAYYGQ-AETVRELLSHVPGTVKSEAPTGVSLVPVLGAES-GLTP 1247
TPLH A G A + E+L+ VP + V S G T
Sbjct: 420 DVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN------------IDVTATNSQGFTL 467
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH A+ G+ VR +L A DA E+G+ LHLA H + +L+ ++
Sbjct: 468 LHHASLKGHALAVRKILARARQLVDA-KKEDGFTALHLAALNNHREVAQILIREGRCDVN 526
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
+R ++ LH+A H +V +L+ G +NA D+ G T LH A + L
Sbjct: 527 VRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL 578
Score = 84.2 bits (199), Expect = 4e-15
Identities = 78/250 (31%), Positives = 115/250 (46%), Gaps = 22/250 (8%)
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
A +D G V +A + LD++R ++ +K G T L +AAY GQ E +R
Sbjct: 289 AQKSDPEHPGRLVVEVALGNA-ARALDLLRRRPE-QVDTKNQGRTALQVAAYLGQVELIR 346
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS 1275
LL +A GV L + G T LH AA R+LL SAG +ADA
Sbjct: 347 LLL---------QARAGVDLPD----DEGNTALHYAALGNQPEATRVLL-SAGCRADAI- 391
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH--IASTHGHYQMVEVLL 1333
N LH+A G + +V L R ++ + D H T LH I++ G +VEVL
Sbjct: 392 NSTQSTALHVAVQRGFLEVVRALCERGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLT 450
Query: 1334 G-QGAEINATDKNGWTPLHCAAKAGH-LNVVKLLCESGASPKSETNLNCAPIWFAASENH 1391
++ AT+ G+T LH A+ GH L V K+L + ++ + AA NH
Sbjct: 451 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 510
Query: 1392 NDVLEYLLHK 1401
+V + L+ +
Sbjct: 511 REVAQILIRE 520
Score = 82.6 bits (195), Expect = 1e-14
Identities = 79/275 (28%), Positives = 130/275 (47%), Gaps = 32/275 (11%)
Query: 804 GETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVK 863
G T LQ+A +++R L++ + A +D D++G +ALHYA +
Sbjct: 329 GRTALQVAAYLGQVELIRLLLQ----------ARAGVDLPDDEGNTALHYAALGNQ---- 374
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALN 923
P A R ++ A S Q+ TA H G +V+ + DV N
Sbjct: 375 -PEATRVLLSAGCRADAINSTQS-----TALHVAVQRGFLEVVRALCER--GCDV----N 422
Query: 924 RQNSIGWTPL--LIACHRGHMQLVNTLLTNHARVDVF--DVEGRSALHLAAEHGY-LQVC 978
++ TPL I+ G +V +LT +DV + +G + LH A+ G+ L V
Sbjct: 423 LPDAHSDTPLHSAISAGTGASGIVE-VLTEVPNIDVTATNSQGFTLLHHASLKGHALAVR 481
Query: 979 DALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
L + +++K +G TALHLAA+N + + + LIR+ ++V K Q+PLHLA
Sbjct: 482 KILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQ 541
Query: 1039 SGQIEVCKLLLELGANIDATDELGQKPIHAAAQNN 1073
+ + LL++ G +++A DE G +H A Q +
Sbjct: 542 QAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRH 576
Score = 77.0 bits (181), Expect = 7e-13
Identities = 99/375 (26%), Positives = 162/375 (43%), Gaps = 27/375 (7%)
Query: 995 GRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
GR + +A N L L+R +D + +T L +AA GQ+E+ +LLL+ A
Sbjct: 298 GRLVVEVALGNAARALD--LLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAG 354
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
+D D+ G +H AA N E ++ L A +T H+A +G ++V+
Sbjct: 355 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCR-ADAINSTQSTALHVAVQRGFLEVVRA 413
Query: 1115 LMKFDRTGVISARNKLNDSTPLQ--LAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHL 1171
L +R ++ + +D TPL ++A G + +V VL T N G T +H
Sbjct: 414 LC--ERGCDVNLPDAHSD-TPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHH 470
Query: 1172 AAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAP 1230
A+ GH V ++ L + K+ G T LH+AA E + L+
Sbjct: 471 ASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIRE---------- 520
Query: 1231 TGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGG 1290
G V V + +PLHLA + +V LL++ AG + A +E G LH+A
Sbjct: 521 -GRCDVNVRNRKL-QSPLHLAVQQAHVGLVPLLVD-AGCSVN-AEDEEGDTALHVALQRH 576
Query: 1291 H-MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG-QGAEINATDKNGWT 1348
+ +V L R +GL ++ V L +GA+++ T+ G +
Sbjct: 577 QLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRS 636
Query: 1349 PLHCAAKAGHLNVVK 1363
PL AA+ L ++
Sbjct: 637 PLDLAAEGRVLKALQ 651
Score = 75.4 bits (177), Expect = 2e-12
Identities = 47/152 (30%), Positives = 71/152 (46%), Gaps = 4/152 (2%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G+ L +A G ++R LL A+ L G+TALH AA + R+L+ G
Sbjct: 328 QGRTALQVAAYLGQVELIRLLLQARAGVDLP--DDEGNTALHYAALGNQPEATRVLLSAG 385
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMH--LAAENGHAAI 179
DA N T LH+A G +V+ + + D TP+H ++A G + I
Sbjct: 386 CRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGI 445
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHA 211
+E+L + + G TL+H ASL GHA
Sbjct: 446 VEVLTEVPNIDVTATNSQGFTLLHHASLKGHA 477
Score = 69.7 bits (163), Expect = 1e-10
Identities = 47/168 (27%), Positives = 79/168 (47%), Gaps = 5/168 (2%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
DL G L A R LLSA + A TALH+A +R +++ R
Sbjct: 356 DLPDDEGNTALHYAALGNQPEATRVLLSAGC--RADAINSTQSTALHVAVQRGFLEVVRA 413
Query: 117 LVDYGAVVDATNGAGQTPLH--IAAAEGDEPLVKYFYGV-RANAAIADNEDRTPMHLAAE 173
L + G V+ + TPLH I+A G +V+ V + +++ T +H A+
Sbjct: 414 LCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASL 473
Query: 174 NGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
GHA + + + + + + +DG T +H+A+LN H + A +L ++G
Sbjct: 474 KGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREG 521
Score = 68.5 bits (160), Expect = 2e-10
Identities = 83/316 (26%), Positives = 133/316 (42%), Gaps = 36/316 (11%)
Query: 731 ETPLHIAARIPDGDKC-ALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
E P + + G+ AL LL+ G T + VAA G + + LLL+
Sbjct: 295 EHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQ---- 350
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGAS 849
+ V + D G T L A P+ R L+ + DA++ ++
Sbjct: 351 --ARAGVDLPD-DEGNTALHYAALGNQPEATRVLLS----------AGCRADAINSTQST 397
Query: 850 ALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN-DVMTE 908
ALH V + +VV+ L E G DV+L H+ +T H AG + E
Sbjct: 398 ALH---------VAVQRGFLEVVRALCERGCDVNLPDAHS-DTPLHSAISAGTGASGIVE 447
Query: 909 MIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR-VDVFDVEGRSALH 967
++ + DV+ NS G+T L A +GH V +L + VD +G +ALH
Sbjct: 448 VLTEVPNIDVTAT----NSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 503
Query: 968 LAAEHGYLQVCDALL-TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
LAA + + +V L+ + +N + R ++ LHLA + LV L+ D ++
Sbjct: 504 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLV-DAGCSVNAED 562
Query: 1027 LKKQTPLHLAAASGQI 1042
+ T LH+A Q+
Sbjct: 563 EEGDTALHVALQRHQL 578
Score = 54.4 bits (125), Expect = 4e-06
Identities = 41/130 (31%), Positives = 64/130 (49%), Gaps = 5/130 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGES-VDVTTNDNYTALHIAVESCKPAVVETLLGYG-A 720
G +H A+ GH + +L + VD D +TALH+A + V + L+ G
Sbjct: 464 GFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRC 523
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
DV++R ++ ++PLH+A + L L+ +G N E+G T +HVA + L L
Sbjct: 524 DVNVR-NRKLQSPLHLAVQQAHVGLVPL-LVDAGCSVNAEDEEGDTALHVALQRHQLLPL 581
Query: 781 VLLLEDGGDP 790
V GGDP
Sbjct: 582 V-ADGAGGDP 590
Score = 50.0 bits (114), Expect = 9e-05
Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 2/120 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L++ V GN + +LL + EQ+ T G TAL +AA V++ R+L+ A VD
Sbjct: 300 LVVEVALGNAARALDLLRRRP-EQVD-TKNQGRTALQVAAYLGQVELIRLLLQARAGVDL 357
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G T LH AA + A ++ T +H+A + G ++ L ++
Sbjct: 358 PDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCER 417
Score = 48.0 bits (109), Expect = 4e-04
Identities = 36/113 (31%), Positives = 57/113 (50%), Gaps = 4/113 (3%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV-VDATNGAGQ 132
G+ VR++L A+ + + A G TALHLAA ++A+IL+ G V+ N Q
Sbjct: 475 GHALAVRKIL-ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQ 533
Query: 133 TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+PLH+A + LV + D E T +H+A + H ++ L+AD
Sbjct: 534 SPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQR-H-QLLPLVAD 584
Score = 46.0 bits (104), Expect = 0.001
Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 6/169 (3%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH--LAARRRDVDMA 114
D + L +AV+ G +VR L + + DT LH ++A +
Sbjct: 389 DAINSTQSTALHVAVQRGFLEVVRAL--CERGCDVNLPDAHSDTPLHSAISAGTGASGIV 446
Query: 115 RILVDYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAA 172
+L + + V ATN G T LH A+ +G V+ A ED T +HLAA
Sbjct: 447 EVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 506
Query: 173 ENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
N H + ++L + + + R + + +H+A H +L G
Sbjct: 507 LNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 555
Score = 43.2 bits (97), Expect = 0.010
Identities = 34/117 (29%), Positives = 47/117 (40%), Gaps = 2/117 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA G V +I LLQ VD+ ++ TALH A +P LL G
Sbjct: 329 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 388
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
Q T LH+A + + L + G N TP+H A G A+
Sbjct: 389 DAINSTQ-STALHVAVQ-RGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 443
Score = 39.5 bits (88), Expect = 0.13
Identities = 28/109 (25%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVE--SCKPAVVETLLGYGADVHI 724
+H A + HVG++ L+ G SV+ + TALH+A++ P V + G + +
Sbjct: 536 LHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQL 595
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK 773
+ + + L +A + G A L GA + G +P+ +AA+
Sbjct: 596 L-SRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE 643
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/107 (24%), Positives = 45/107 (42%), Gaps = 1/107 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
LL R E + T G+T L +A+ G +++ +LL A ++ D G T LH AA
Sbjct: 315 LLRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 373
Query: 1358 HLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
++L +G + + + A +V+ L + D
Sbjct: 374 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 420
Score = 37.9 bits (84), Expect = 0.39
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 1/76 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H AA LL G D + TALH+AV+ VV L G D
Sbjct: 361 EGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 420
Query: 722 VHIRGGKQRETPLHIA 737
V++ +TPLH A
Sbjct: 421 VNLPDA-HSDTPLHSA 435
>AK096295-1|BAC04752.1| 681|Homo sapiens protein ( Homo sapiens cDNA
FLJ38976 fis, clone NT2RI2004099, weakly similar to
ANKYRIN 2. ).
Length = 681
Score = 108 bits (260), Expect = 2e-22
Identities = 79/250 (31%), Positives = 127/250 (50%), Gaps = 8/250 (3%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G T L +A + G ++L+ LL A VD+ D EG +ALH AA + LL+
Sbjct: 191 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 250
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH--LAAASGQIEVCK 1046
++ TALH+A G+ +V+ L + +++ TPLH ++A +G + +
Sbjct: 251 DAINSTQSTALHVAVQRGFLEVVRALC-ERGCDVNLPDAHSDTPLHSAISAGTGASGIVE 309
Query: 1047 LLLELGANID--ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
+L E+ NID AT+ G +H A+ ++ V+ L + LV A +DG T H+AA
Sbjct: 310 VLTEV-PNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKEEDGFTALHLAA 368
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
+ +V + L++ R V KL +PL LA + H +V +LV AG S E+
Sbjct: 369 LNNHREVAQILIREGRCDVNVRNRKL--QSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEE 426
Query: 1165 GLTAVHLAAE 1174
G TA+H+A +
Sbjct: 427 GDTALHVALQ 436
Score = 101 bits (241), Expect = 4e-20
Identities = 70/249 (28%), Positives = 123/249 (49%), Gaps = 8/249 (3%)
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
+GR+AL +AA G +++ LL +A ++ G TALH AA+ + L+
Sbjct: 190 QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLL-SAGC 248
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA--AQNNYSEVV 1078
D + + T LH+A G +EV + L E G +++ D P+H+A A S +V
Sbjct: 249 RADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIV 308
Query: 1079 QLFLQQHPNL-VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
++ L + PN+ V AT G T H A+++G + +++ R ++ A+ + + T L
Sbjct: 309 EV-LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQ-LVDAKEE-DGFTALH 365
Query: 1138 LAAEGGHADVVRVLVRAG-ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
LAA H +V ++L+R G NR + +HLA + H ++ ++ + +
Sbjct: 366 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 425
Query: 1197 LGLTPLHIA 1205
G T LH+A
Sbjct: 426 EGDTALHVA 434
Score = 97.9 bits (233), Expect = 3e-19
Identities = 72/245 (29%), Positives = 119/245 (48%), Gaps = 17/245 (6%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
T LQ+AA G +++R+L++A A + G TA+H AA V+ S +
Sbjct: 193 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 252
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLH--LA 1251
T LH+A G E VR L E V+L A S TPLH ++
Sbjct: 253 INSTQSTALHVAVQRGFLEVVRALC---------ERGCDVNLPD---AHSD-TPLHSAIS 299
Query: 1252 AYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDR 1311
A G +V +L + A+N G+ LH A GH V +L+R+ +L+ + +
Sbjct: 300 AGTGASGIVEVLTEVPNIDV-TATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKEE 358
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
G T LH+A+ + H ++ ++L+ +G ++N ++ +PLH A + H+ +V LL ++G
Sbjct: 359 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 418
Query: 1371 SPKSE 1375
S +E
Sbjct: 419 SVNAE 423
Score = 94.3 bits (224), Expect = 4e-18
Identities = 86/292 (29%), Positives = 128/292 (43%), Gaps = 20/292 (6%)
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNK 1129
A N + + L L++ P V T G T +AA G V++I L++ R GV ++
Sbjct: 167 ALGNAARALDL-LRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQA-RAGVDLPDDE 223
Query: 1130 LNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT 1189
N T L AA G + RVL+ AG N TA+H+A + G V+ +
Sbjct: 224 GN--TALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC 281
Query: 1190 LRISSKKLGLTPLHIAAYYGQ-AETVRELLSHVPGTVKSEAPTGVSLVPVLGAES-GLTP 1247
TPLH A G A + E+L+ VP + V S G T
Sbjct: 282 DVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN------------IDVTATNSQGFTL 329
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH A+ G+ VR +L A DA E+G+ LHLA H + +L+ ++
Sbjct: 330 LHHASLKGHALAVRKILARARQLVDA-KEEDGFTALHLAALNNHREVAQILIREGRCDVN 388
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
+R ++ LH+A H +V +L+ G +NA D+ G T LH A + L
Sbjct: 389 VRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL 440
Score = 84.2 bits (199), Expect = 4e-15
Identities = 78/250 (31%), Positives = 115/250 (46%), Gaps = 22/250 (8%)
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
A +D G V +A + LD++R ++ +K G T L +AAY GQ E +R
Sbjct: 151 AQKSDPEHPGRLVVEVALGNA-ARALDLLRRRPE-QVDTKNQGRTALQVAAYLGQVELIR 208
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS 1275
LL +A GV L + G T LH AA R+LL SAG +ADA
Sbjct: 209 LLL---------QARAGVDLPD----DEGNTALHYAALGNQPEATRVLL-SAGCRADAI- 253
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH--IASTHGHYQMVEVLL 1333
N LH+A G + +V L R ++ + D H T LH I++ G +VEVL
Sbjct: 254 NSTQSTALHVAVQRGFLEVVRALCERGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLT 312
Query: 1334 G-QGAEINATDKNGWTPLHCAAKAGH-LNVVKLLCESGASPKSETNLNCAPIWFAASENH 1391
++ AT+ G+T LH A+ GH L V K+L + ++ + AA NH
Sbjct: 313 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKEEDGFTALHLAALNNH 372
Query: 1392 NDVLEYLLHK 1401
+V + L+ +
Sbjct: 373 REVAQILIRE 382
Score = 82.6 bits (195), Expect = 1e-14
Identities = 79/275 (28%), Positives = 130/275 (47%), Gaps = 32/275 (11%)
Query: 804 GETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVK 863
G T LQ+A +++R L++ + A +D D++G +ALHYA +
Sbjct: 191 GRTALQVAAYLGQVELIRLLLQ----------ARAGVDLPDDEGNTALHYAALGNQ---- 236
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALN 923
P A R ++ A S Q+ TA H G +V+ + DV N
Sbjct: 237 -PEATRVLLSAGCRADAINSTQS-----TALHVAVQRGFLEVVRALCER--GCDV----N 284
Query: 924 RQNSIGWTPL--LIACHRGHMQLVNTLLTNHARVDVF--DVEGRSALHLAAEHGY-LQVC 978
++ TPL I+ G +V +LT +DV + +G + LH A+ G+ L V
Sbjct: 285 LPDAHSDTPLHSAISAGTGASGIVE-VLTEVPNIDVTATNSQGFTLLHHASLKGHALAVR 343
Query: 979 DALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
L + +++K +G TALHLAA+N + + + LIR+ ++V K Q+PLHLA
Sbjct: 344 KILARARQLVDAKEEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQ 403
Query: 1039 SGQIEVCKLLLELGANIDATDELGQKPIHAAAQNN 1073
+ + LL++ G +++A DE G +H A Q +
Sbjct: 404 QAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRH 438
Score = 75.4 bits (177), Expect = 2e-12
Identities = 98/375 (26%), Positives = 162/375 (43%), Gaps = 27/375 (7%)
Query: 995 GRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
GR + +A N L L+R +D + +T L +AA GQ+E+ +LLL+ A
Sbjct: 160 GRLVVEVALGNAARALD--LLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAG 216
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
+D D+ G +H AA N E ++ L A +T H+A +G ++V+
Sbjct: 217 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCR-ADAINSTQSTALHVAVQRGFLEVVRA 275
Query: 1115 LMKFDRTGVISARNKLNDSTPLQ--LAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHL 1171
L +R ++ + +D TPL ++A G + +V VL T N G T +H
Sbjct: 276 LC--ERGCDVNLPDAHSD-TPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHH 332
Query: 1172 AAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAP 1230
A+ GH V ++ L + ++ G T LH+AA E + L+
Sbjct: 333 ASLKGHALAVRKILARARQLVDAKEEDGFTALHLAALNNHREVAQILIRE---------- 382
Query: 1231 TGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGG 1290
G V V + +PLHLA + +V LL++ AG + A +E G LH+A
Sbjct: 383 -GRCDVNVRNRKL-QSPLHLAVQQAHVGLVPLLVD-AGCSVN-AEDEEGDTALHVALQRH 438
Query: 1291 H-MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG-QGAEINATDKNGWT 1348
+ +V L R +GL ++ V L +GA+++ T+ G +
Sbjct: 439 QLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRS 498
Query: 1349 PLHCAAKAGHLNVVK 1363
PL AA+ L ++
Sbjct: 499 PLDLAAEGRVLKALQ 513
Score = 75.4 bits (177), Expect = 2e-12
Identities = 47/152 (30%), Positives = 71/152 (46%), Gaps = 4/152 (2%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G+ L +A G ++R LL A+ L G+TALH AA + R+L+ G
Sbjct: 190 QGRTALQVAAYLGQVELIRLLLQARAGVDLP--DDEGNTALHYAALGNQPEATRVLLSAG 247
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMH--LAAENGHAAI 179
DA N T LH+A G +V+ + + D TP+H ++A G + I
Sbjct: 248 CRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGI 307
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHA 211
+E+L + + G TL+H ASL GHA
Sbjct: 308 VEVLTEVPNIDVTATNSQGFTLLHHASLKGHA 339
Score = 69.7 bits (163), Expect = 1e-10
Identities = 83/316 (26%), Positives = 134/316 (42%), Gaps = 36/316 (11%)
Query: 731 ETPLHIAARIPDGDKC-ALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
E P + + G+ AL LL+ G T + VAA G + + LLL+
Sbjct: 157 EHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQ---- 212
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGAS 849
+ V + D G T L A P+ R L+ + DA++ ++
Sbjct: 213 --ARAGVDLPD-DEGNTALHYAALGNQPEATRVLLS----------AGCRADAINSTQST 259
Query: 850 ALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN-DVMTE 908
ALH V + +VV+ L E G DV+L H+ +T H AG + E
Sbjct: 260 ALH---------VAVQRGFLEVVRALCERGCDVNLPDAHS-DTPLHSAISAGTGASGIVE 309
Query: 909 MIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR-VDVFDVEGRSALH 967
++ + DV+ NS G+T L A +GH V +L + VD + +G +ALH
Sbjct: 310 VLTEVPNIDVTAT----NSQGFTLLHHASLKGHALAVRKILARARQLVDAKEEDGFTALH 365
Query: 968 LAAEHGYLQVCDALL-TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
LAA + + +V L+ + +N + R ++ LHLA + LV L+ D ++
Sbjct: 366 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLV-DAGCSVNAED 424
Query: 1027 LKKQTPLHLAAASGQI 1042
+ T LH+A Q+
Sbjct: 425 EEGDTALHVALQRHQL 440
Score = 69.7 bits (163), Expect = 1e-10
Identities = 47/168 (27%), Positives = 79/168 (47%), Gaps = 5/168 (2%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
DL G L A R LLSA + A TALH+A +R +++ R
Sbjct: 218 DLPDDEGNTALHYAALGNQPEATRVLLSAGC--RADAINSTQSTALHVAVQRGFLEVVRA 275
Query: 117 LVDYGAVVDATNGAGQTPLH--IAAAEGDEPLVKYFYGV-RANAAIADNEDRTPMHLAAE 173
L + G V+ + TPLH I+A G +V+ V + +++ T +H A+
Sbjct: 276 LCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASL 335
Query: 174 NGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
GHA + + + + + + +DG T +H+A+LN H + A +L ++G
Sbjct: 336 KGHALAVRKILARARQLVDAKEEDGFTALHLAALNNHREVAQILIREG 383
Score = 54.4 bits (125), Expect = 4e-06
Identities = 41/130 (31%), Positives = 64/130 (49%), Gaps = 5/130 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGES-VDVTTNDNYTALHIAVESCKPAVVETLLGYG-A 720
G +H A+ GH + +L + VD D +TALH+A + V + L+ G
Sbjct: 326 GFTLLHHASLKGHALAVRKILARARQLVDAKEEDGFTALHLAALNNHREVAQILIREGRC 385
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
DV++R ++ ++PLH+A + L L+ +G N E+G T +HVA + L L
Sbjct: 386 DVNVR-NRKLQSPLHLAVQQAHVGLVPL-LVDAGCSVNAEDEEGDTALHVALQRHQLLPL 443
Query: 781 VLLLEDGGDP 790
V GGDP
Sbjct: 444 V-ADGAGGDP 452
Score = 50.0 bits (114), Expect = 9e-05
Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 2/120 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L++ V GN + +LL + EQ+ T G TAL +AA V++ R+L+ A VD
Sbjct: 162 LVVEVALGNAARALDLLRRRP-EQVD-TKNQGRTALQVAAYLGQVELIRLLLQARAGVDL 219
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G T LH AA + A ++ T +H+A + G ++ L ++
Sbjct: 220 PDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCER 279
Score = 48.0 bits (109), Expect = 4e-04
Identities = 36/113 (31%), Positives = 57/113 (50%), Gaps = 4/113 (3%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV-VDATNGAGQ 132
G+ VR++L A+ + + A G TALHLAA ++A+IL+ G V+ N Q
Sbjct: 337 GHALAVRKIL-ARARQLVDAKEEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQ 395
Query: 133 TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+PLH+A + LV + D E T +H+A + H ++ L+AD
Sbjct: 396 SPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQR-H-QLLPLVAD 446
Score = 46.0 bits (104), Expect = 0.001
Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 6/169 (3%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH--LAARRRDVDMA 114
D + L +AV+ G +VR L + + DT LH ++A +
Sbjct: 251 DAINSTQSTALHVAVQRGFLEVVRAL--CERGCDVNLPDAHSDTPLHSAISAGTGASGIV 308
Query: 115 RILVDYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAA 172
+L + + V ATN G T LH A+ +G V+ A ED T +HLAA
Sbjct: 309 EVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKEEDGFTALHLAA 368
Query: 173 ENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
N H + ++L + + + R + + +H+A H +L G
Sbjct: 369 LNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 417
Score = 43.2 bits (97), Expect = 0.010
Identities = 34/117 (29%), Positives = 47/117 (40%), Gaps = 2/117 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA G V +I LLQ VD+ ++ TALH A +P LL G
Sbjct: 191 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 250
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
Q T LH+A + + L + G N TP+H A G A+
Sbjct: 251 DAINSTQ-STALHVAVQ-RGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 305
Score = 39.5 bits (88), Expect = 0.13
Identities = 28/109 (25%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVE--SCKPAVVETLLGYGADVHI 724
+H A + HVG++ L+ G SV+ + TALH+A++ P V + G + +
Sbjct: 398 LHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQL 457
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK 773
+ + + L +A + G A L GA + G +P+ +AA+
Sbjct: 458 L-SRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE 505
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/107 (24%), Positives = 45/107 (42%), Gaps = 1/107 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
LL R E + T G+T L +A+ G +++ +LL A ++ D G T LH AA
Sbjct: 177 LLRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 235
Query: 1358 HLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
++L +G + + + A +V+ L + D
Sbjct: 236 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 282
Score = 37.9 bits (84), Expect = 0.39
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 1/76 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H AA LL G D + TALH+AV+ VV L G D
Sbjct: 223 EGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 282
Query: 722 VHIRGGKQRETPLHIA 737
V++ +TPLH A
Sbjct: 283 VNLPDA-HSDTPLHSA 297
>AK095914-1|BAC04646.1| 681|Homo sapiens protein ( Homo sapiens cDNA
FLJ38595 fis, clone HEART2001773, weakly similar to
ANKYRIN 2. ).
Length = 681
Score = 108 bits (260), Expect = 2e-22
Identities = 79/250 (31%), Positives = 127/250 (50%), Gaps = 8/250 (3%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G T L +A + G ++L+ LL A VD+ D EG +ALH AA + LL+
Sbjct: 191 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 250
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH--LAAASGQIEVCK 1046
++ TALH+A G+ +V+ L + +++ TPLH ++A +G + +
Sbjct: 251 DAINSTQSTALHVAVQRGFLEVVRALC-ERGCDVNLPDAHSDTPLHSAISAGTGASGIVE 309
Query: 1047 LLLELGANID--ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
+L E+ NID AT+ G +H A+ ++ V+ L + LV A +DG T H+AA
Sbjct: 310 VLTEV-PNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 368
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
+ +V + L++ R V KL +PL LA + H +V +LV AG S E+
Sbjct: 369 LNNHREVAQILIREGRCDVNVRNRKL--QSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEE 426
Query: 1165 GLTAVHLAAE 1174
G TA+H+A +
Sbjct: 427 GDTALHVALQ 436
Score = 101 bits (242), Expect = 3e-20
Identities = 71/249 (28%), Positives = 123/249 (49%), Gaps = 8/249 (3%)
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
+GR+AL +AA G +++ LL +A ++ G TALH AA+ + L+
Sbjct: 190 QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLL-SAGC 248
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA--AQNNYSEVV 1078
D + + T LH+A G +EV + L E G +++ D P+H+A A S +V
Sbjct: 249 RADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIV 308
Query: 1079 QLFLQQHPNL-VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
++ L + PN+ V AT G T H A+++G + +++ R ++ A+ K + T L
Sbjct: 309 EV-LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQ-LVDAK-KEDGFTALH 365
Query: 1138 LAAEGGHADVVRVLVRAG-ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
LAA H +V ++L+R G NR + +HLA + H ++ ++ + +
Sbjct: 366 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 425
Query: 1197 LGLTPLHIA 1205
G T LH+A
Sbjct: 426 EGDTALHVA 434
Score = 96.7 bits (230), Expect = 8e-19
Identities = 72/245 (29%), Positives = 118/245 (48%), Gaps = 17/245 (6%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
T LQ+AA G +++R+L++A A + G TA+H AA V+ S +
Sbjct: 193 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 252
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLH--LA 1251
T LH+A G E VR L E V+L A S TPLH ++
Sbjct: 253 INSTQSTALHVAVQRGFLEVVRALC---------ERGCDVNLPD---AHSD-TPLHSAIS 299
Query: 1252 AYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDR 1311
A G +V +L + A+N G+ LH A GH V +L+R+ +L+ +
Sbjct: 300 AGTGASGIVEVLTEVPNIDV-TATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE 358
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
G T LH+A+ + H ++ ++L+ +G ++N ++ +PLH A + H+ +V LL ++G
Sbjct: 359 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 418
Query: 1371 SPKSE 1375
S +E
Sbjct: 419 SVNAE 423
Score = 94.3 bits (224), Expect = 4e-18
Identities = 86/292 (29%), Positives = 128/292 (43%), Gaps = 20/292 (6%)
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNK 1129
A N + + L L++ P V T G T +AA G V++I L++ R GV ++
Sbjct: 167 ALGNAARALDL-LRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQA-RAGVDLPDDE 223
Query: 1130 LNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT 1189
N T L AA G + RVL+ AG N TA+H+A + G V+ +
Sbjct: 224 GN--TALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC 281
Query: 1190 LRISSKKLGLTPLHIAAYYGQ-AETVRELLSHVPGTVKSEAPTGVSLVPVLGAES-GLTP 1247
TPLH A G A + E+L+ VP + V S G T
Sbjct: 282 DVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN------------IDVTATNSQGFTL 329
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH A+ G+ VR +L A DA E+G+ LHLA H + +L+ ++
Sbjct: 330 LHHASLKGHALAVRKILARARQLVDA-KKEDGFTALHLAALNNHREVAQILIREGRCDVN 388
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
+R ++ LH+A H +V +L+ G +NA D+ G T LH A + L
Sbjct: 389 VRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL 440
Score = 84.2 bits (199), Expect = 4e-15
Identities = 78/250 (31%), Positives = 115/250 (46%), Gaps = 22/250 (8%)
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
A +D G V +A + LD++R ++ +K G T L +AAY GQ E +R
Sbjct: 151 AQKSDPEHPGRLVVEVALGNA-ARALDLLRRRPE-QVDTKNQGRTALQVAAYLGQVELIR 208
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS 1275
LL +A GV L + G T LH AA R+LL SAG +ADA
Sbjct: 209 LLL---------QARAGVDLPD----DEGNTALHYAALGNQPEATRVLL-SAGCRADAI- 253
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH--IASTHGHYQMVEVLL 1333
N LH+A G + +V L R ++ + D H T LH I++ G +VEVL
Sbjct: 254 NSTQSTALHVAVQRGFLEVVRALCERGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLT 312
Query: 1334 G-QGAEINATDKNGWTPLHCAAKAGH-LNVVKLLCESGASPKSETNLNCAPIWFAASENH 1391
++ AT+ G+T LH A+ GH L V K+L + ++ + AA NH
Sbjct: 313 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 372
Query: 1392 NDVLEYLLHK 1401
+V + L+ +
Sbjct: 373 REVAQILIRE 382
Score = 82.6 bits (195), Expect = 1e-14
Identities = 79/275 (28%), Positives = 130/275 (47%), Gaps = 32/275 (11%)
Query: 804 GETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVK 863
G T LQ+A +++R L++ + A +D D++G +ALHYA +
Sbjct: 191 GRTALQVAAYLGQVELIRLLLQ----------ARAGVDLPDDEGNTALHYAALGNQ---- 236
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALN 923
P A R ++ A S Q+ TA H G +V+ + DV N
Sbjct: 237 -PEATRVLLSAGCRADAINSTQS-----TALHVAVQRGFLEVVRALCER--GCDV----N 284
Query: 924 RQNSIGWTPL--LIACHRGHMQLVNTLLTNHARVDVF--DVEGRSALHLAAEHGY-LQVC 978
++ TPL I+ G +V +LT +DV + +G + LH A+ G+ L V
Sbjct: 285 LPDAHSDTPLHSAISAGTGASGIVE-VLTEVPNIDVTATNSQGFTLLHHASLKGHALAVR 343
Query: 979 DALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
L + +++K +G TALHLAA+N + + + LIR+ ++V K Q+PLHLA
Sbjct: 344 KILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQ 403
Query: 1039 SGQIEVCKLLLELGANIDATDELGQKPIHAAAQNN 1073
+ + LL++ G +++A DE G +H A Q +
Sbjct: 404 QAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRH 438
Score = 77.0 bits (181), Expect = 7e-13
Identities = 99/375 (26%), Positives = 162/375 (43%), Gaps = 27/375 (7%)
Query: 995 GRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
GR + +A N L L+R +D + +T L +AA GQ+E+ +LLL+ A
Sbjct: 160 GRLVVEVALGNAARALD--LLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAG 216
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
+D D+ G +H AA N E ++ L A +T H+A +G ++V+
Sbjct: 217 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCR-ADAINSTQSTALHVAVQRGFLEVVRA 275
Query: 1115 LMKFDRTGVISARNKLNDSTPLQ--LAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHL 1171
L +R ++ + +D TPL ++A G + +V VL T N G T +H
Sbjct: 276 LC--ERGCDVNLPDAHSD-TPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHH 332
Query: 1172 AAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAP 1230
A+ GH V ++ L + K+ G T LH+AA E + L+
Sbjct: 333 ASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIRE---------- 382
Query: 1231 TGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGG 1290
G V V + +PLHLA + +V LL++ AG + A +E G LH+A
Sbjct: 383 -GRCDVNVRNRKL-QSPLHLAVQQAHVGLVPLLVD-AGCSVN-AEDEEGDTALHVALQRH 438
Query: 1291 H-MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG-QGAEINATDKNGWT 1348
+ +V L R +GL ++ V L +GA+++ T+ G +
Sbjct: 439 QLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRS 498
Query: 1349 PLHCAAKAGHLNVVK 1363
PL AA+ L ++
Sbjct: 499 PLDLAAEGRVLKALQ 513
Score = 75.4 bits (177), Expect = 2e-12
Identities = 47/152 (30%), Positives = 71/152 (46%), Gaps = 4/152 (2%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G+ L +A G ++R LL A+ L G+TALH AA + R+L+ G
Sbjct: 190 QGRTALQVAAYLGQVELIRLLLQARAGVDLP--DDEGNTALHYAALGNQPEATRVLLSAG 247
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMH--LAAENGHAAI 179
DA N T LH+A G +V+ + + D TP+H ++A G + I
Sbjct: 248 CRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGI 307
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHA 211
+E+L + + G TL+H ASL GHA
Sbjct: 308 VEVLTEVPNIDVTATNSQGFTLLHHASLKGHA 339
Score = 69.7 bits (163), Expect = 1e-10
Identities = 47/168 (27%), Positives = 79/168 (47%), Gaps = 5/168 (2%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
DL G L A R LLSA + A TALH+A +R +++ R
Sbjct: 218 DLPDDEGNTALHYAALGNQPEATRVLLSAGC--RADAINSTQSTALHVAVQRGFLEVVRA 275
Query: 117 LVDYGAVVDATNGAGQTPLH--IAAAEGDEPLVKYFYGV-RANAAIADNEDRTPMHLAAE 173
L + G V+ + TPLH I+A G +V+ V + +++ T +H A+
Sbjct: 276 LCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASL 335
Query: 174 NGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
GHA + + + + + + +DG T +H+A+LN H + A +L ++G
Sbjct: 336 KGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREG 383
Score = 68.5 bits (160), Expect = 2e-10
Identities = 83/316 (26%), Positives = 133/316 (42%), Gaps = 36/316 (11%)
Query: 731 ETPLHIAARIPDGDKC-ALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
E P + + G+ AL LL+ G T + VAA G + + LLL+
Sbjct: 157 EHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQ---- 212
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGAS 849
+ V + D G T L A P+ R L+ + DA++ ++
Sbjct: 213 --ARAGVDLPD-DEGNTALHYAALGNQPEATRVLLS----------AGCRADAINSTQST 259
Query: 850 ALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN-DVMTE 908
ALH V + +VV+ L E G DV+L H+ +T H AG + E
Sbjct: 260 ALH---------VAVQRGFLEVVRALCERGCDVNLPDAHS-DTPLHSAISAGTGASGIVE 309
Query: 909 MIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR-VDVFDVEGRSALH 967
++ + DV+ NS G+T L A +GH V +L + VD +G +ALH
Sbjct: 310 VLTEVPNIDVTAT----NSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 365
Query: 968 LAAEHGYLQVCDALL-TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
LAA + + +V L+ + +N + R ++ LHLA + LV L+ D ++
Sbjct: 366 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLV-DAGCSVNAED 424
Query: 1027 LKKQTPLHLAAASGQI 1042
+ T LH+A Q+
Sbjct: 425 EEGDTALHVALQRHQL 440
Score = 54.4 bits (125), Expect = 4e-06
Identities = 41/130 (31%), Positives = 64/130 (49%), Gaps = 5/130 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGES-VDVTTNDNYTALHIAVESCKPAVVETLLGYG-A 720
G +H A+ GH + +L + VD D +TALH+A + V + L+ G
Sbjct: 326 GFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRC 385
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
DV++R ++ ++PLH+A + L L+ +G N E+G T +HVA + L L
Sbjct: 386 DVNVR-NRKLQSPLHLAVQQAHVGLVPL-LVDAGCSVNAEDEEGDTALHVALQRHQLLPL 443
Query: 781 VLLLEDGGDP 790
V GGDP
Sbjct: 444 V-ADGAGGDP 452
Score = 50.0 bits (114), Expect = 9e-05
Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 2/120 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L++ V GN + +LL + EQ+ T G TAL +AA V++ R+L+ A VD
Sbjct: 162 LVVEVALGNAARALDLLRRRP-EQVD-TKNQGRTALQVAAYLGQVELIRLLLQARAGVDL 219
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G T LH AA + A ++ T +H+A + G ++ L ++
Sbjct: 220 PDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCER 279
Score = 48.0 bits (109), Expect = 4e-04
Identities = 36/113 (31%), Positives = 57/113 (50%), Gaps = 4/113 (3%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV-VDATNGAGQ 132
G+ VR++L A+ + + A G TALHLAA ++A+IL+ G V+ N Q
Sbjct: 337 GHALAVRKIL-ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQ 395
Query: 133 TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+PLH+A + LV + D E T +H+A + H ++ L+AD
Sbjct: 396 SPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQR-H-QLLPLVAD 446
Score = 46.0 bits (104), Expect = 0.001
Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 6/169 (3%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH--LAARRRDVDMA 114
D + L +AV+ G +VR L + + DT LH ++A +
Sbjct: 251 DAINSTQSTALHVAVQRGFLEVVRAL--CERGCDVNLPDAHSDTPLHSAISAGTGASGIV 308
Query: 115 RILVDYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAA 172
+L + + V ATN G T LH A+ +G V+ A ED T +HLAA
Sbjct: 309 EVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 368
Query: 173 ENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
N H + ++L + + + R + + +H+A H +L G
Sbjct: 369 LNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 417
Score = 43.2 bits (97), Expect = 0.010
Identities = 34/117 (29%), Positives = 47/117 (40%), Gaps = 2/117 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA G V +I LLQ VD+ ++ TALH A +P LL G
Sbjct: 191 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 250
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
Q T LH+A + + L + G N TP+H A G A+
Sbjct: 251 DAINSTQ-STALHVAVQ-RGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 305
Score = 39.5 bits (88), Expect = 0.13
Identities = 28/109 (25%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVE--SCKPAVVETLLGYGADVHI 724
+H A + HVG++ L+ G SV+ + TALH+A++ P V + G + +
Sbjct: 398 LHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQL 457
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK 773
+ + + L +A + G A L GA + G +P+ +AA+
Sbjct: 458 L-SRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE 505
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/107 (24%), Positives = 45/107 (42%), Gaps = 1/107 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
LL R E + T G+T L +A+ G +++ +LL A ++ D G T LH AA
Sbjct: 177 LLRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 235
Query: 1358 HLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
++L +G + + + A +V+ L + D
Sbjct: 236 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 282
Score = 37.9 bits (84), Expect = 0.39
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 1/76 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H AA LL G D + TALH+AV+ VV L G D
Sbjct: 223 EGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 282
Query: 722 VHIRGGKQRETPLHIA 737
V++ +TPLH A
Sbjct: 283 VNLPDA-HSDTPLHSA 297
>AK091610-1|BAC03707.1| 645|Homo sapiens protein ( Homo sapiens cDNA
FLJ34291 fis, clone FEBRA2004620, weakly similar to
ANKYRIN 2. ).
Length = 645
Score = 108 bits (260), Expect = 2e-22
Identities = 79/250 (31%), Positives = 127/250 (50%), Gaps = 8/250 (3%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G T L +A + G ++L+ LL A VD+ D EG +ALH AA + LL+
Sbjct: 155 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 214
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH--LAAASGQIEVCK 1046
++ TALH+A G+ +V+ L + +++ TPLH ++A +G + +
Sbjct: 215 DAINSTQSTALHVAVQRGFLEVVRALC-ERGCDVNLPDAHSDTPLHSAISAGTGASGIVE 273
Query: 1047 LLLELGANID--ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
+L E+ NID AT+ G +H A+ ++ V+ L + LV A +DG T H+AA
Sbjct: 274 VLTEV-PNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 332
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
+ +V + L++ R V KL +PL LA + H +V +LV AG S E+
Sbjct: 333 LNNHREVAQILIREGRCDVNVRNRKL--QSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEE 390
Query: 1165 GLTAVHLAAE 1174
G TA+H+A +
Sbjct: 391 GDTALHVALQ 400
Score = 101 bits (242), Expect = 3e-20
Identities = 71/249 (28%), Positives = 123/249 (49%), Gaps = 8/249 (3%)
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
+GR+AL +AA G +++ LL +A ++ G TALH AA+ + L+
Sbjct: 154 QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLL-SAGC 212
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA--AQNNYSEVV 1078
D + + T LH+A G +EV + L E G +++ D P+H+A A S +V
Sbjct: 213 RADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIV 272
Query: 1079 QLFLQQHPNL-VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
++ L + PN+ V AT G T H A+++G + +++ R ++ A+ K + T L
Sbjct: 273 EV-LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQ-LVDAK-KEDGFTALH 329
Query: 1138 LAAEGGHADVVRVLVRAG-ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
LAA H +V ++L+R G NR + +HLA + H ++ ++ + +
Sbjct: 330 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 389
Query: 1197 LGLTPLHIA 1205
G T LH+A
Sbjct: 390 EGDTALHVA 398
Score = 96.7 bits (230), Expect = 8e-19
Identities = 72/245 (29%), Positives = 118/245 (48%), Gaps = 17/245 (6%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
T LQ+AA G +++R+L++A A + G TA+H AA V+ S +
Sbjct: 157 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 216
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLH--LA 1251
T LH+A G E VR L E V+L A S TPLH ++
Sbjct: 217 INSTQSTALHVAVQRGFLEVVRALC---------ERGCDVNLPD---AHSD-TPLHSAIS 263
Query: 1252 AYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDR 1311
A G +V +L + A+N G+ LH A GH V +L+R+ +L+ +
Sbjct: 264 AGTGASGIVEVLTEVPNIDV-TATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE 322
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
G T LH+A+ + H ++ ++L+ +G ++N ++ +PLH A + H+ +V LL ++G
Sbjct: 323 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 382
Query: 1371 SPKSE 1375
S +E
Sbjct: 383 SVNAE 387
Score = 94.3 bits (224), Expect = 4e-18
Identities = 86/292 (29%), Positives = 128/292 (43%), Gaps = 20/292 (6%)
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNK 1129
A N + + L L++ P V T G T +AA G V++I L++ R GV ++
Sbjct: 131 ALGNAARALDL-LRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQA-RAGVDLPDDE 187
Query: 1130 LNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT 1189
N T L AA G + RVL+ AG N TA+H+A + G V+ +
Sbjct: 188 GN--TALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC 245
Query: 1190 LRISSKKLGLTPLHIAAYYGQ-AETVRELLSHVPGTVKSEAPTGVSLVPVLGAES-GLTP 1247
TPLH A G A + E+L+ VP + V S G T
Sbjct: 246 DVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN------------IDVTATNSQGFTL 293
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH A+ G+ VR +L A DA E+G+ LHLA H + +L+ ++
Sbjct: 294 LHHASLKGHALAVRKILARARQLVDA-KKEDGFTALHLAALNNHREVAQILIREGRCDVN 352
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
+R ++ LH+A H +V +L+ G +NA D+ G T LH A + L
Sbjct: 353 VRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL 404
Score = 84.2 bits (199), Expect = 4e-15
Identities = 78/250 (31%), Positives = 115/250 (46%), Gaps = 22/250 (8%)
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
A +D G V +A + LD++R ++ +K G T L +AAY GQ E +R
Sbjct: 115 AQKSDPEHPGRLVVEVALGNA-ARALDLLRRRPE-QVDTKNQGRTALQVAAYLGQVELIR 172
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS 1275
LL +A GV L + G T LH AA R+LL SAG +ADA
Sbjct: 173 LLL---------QARAGVDLPD----DEGNTALHYAALGNQPEATRVLL-SAGCRADAI- 217
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH--IASTHGHYQMVEVLL 1333
N LH+A G + +V L R ++ + D H T LH I++ G +VEVL
Sbjct: 218 NSTQSTALHVAVQRGFLEVVRALCERGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLT 276
Query: 1334 G-QGAEINATDKNGWTPLHCAAKAGH-LNVVKLLCESGASPKSETNLNCAPIWFAASENH 1391
++ AT+ G+T LH A+ GH L V K+L + ++ + AA NH
Sbjct: 277 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 336
Query: 1392 NDVLEYLLHK 1401
+V + L+ +
Sbjct: 337 REVAQILIRE 346
Score = 82.6 bits (195), Expect = 1e-14
Identities = 79/275 (28%), Positives = 130/275 (47%), Gaps = 32/275 (11%)
Query: 804 GETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVK 863
G T LQ+A +++R L++ + A +D D++G +ALHYA +
Sbjct: 155 GRTALQVAAYLGQVELIRLLLQ----------ARAGVDLPDDEGNTALHYAALGNQ---- 200
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALN 923
P A R ++ A S Q+ TA H G +V+ + DV N
Sbjct: 201 -PEATRVLLSAGCRADAINSTQS-----TALHVAVQRGFLEVVRALCER--GCDV----N 248
Query: 924 RQNSIGWTPL--LIACHRGHMQLVNTLLTNHARVDVF--DVEGRSALHLAAEHGY-LQVC 978
++ TPL I+ G +V +LT +DV + +G + LH A+ G+ L V
Sbjct: 249 LPDAHSDTPLHSAISAGTGASGIVE-VLTEVPNIDVTATNSQGFTLLHHASLKGHALAVR 307
Query: 979 DALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
L + +++K +G TALHLAA+N + + + LIR+ ++V K Q+PLHLA
Sbjct: 308 KILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQ 367
Query: 1039 SGQIEVCKLLLELGANIDATDELGQKPIHAAAQNN 1073
+ + LL++ G +++A DE G +H A Q +
Sbjct: 368 QAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRH 402
Score = 77.0 bits (181), Expect = 7e-13
Identities = 99/375 (26%), Positives = 162/375 (43%), Gaps = 27/375 (7%)
Query: 995 GRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
GR + +A N L L+R +D + +T L +AA GQ+E+ +LLL+ A
Sbjct: 124 GRLVVEVALGNAARALD--LLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAG 180
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
+D D+ G +H AA N E ++ L A +T H+A +G ++V+
Sbjct: 181 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCR-ADAINSTQSTALHVAVQRGFLEVVRA 239
Query: 1115 LMKFDRTGVISARNKLNDSTPLQ--LAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHL 1171
L +R ++ + +D TPL ++A G + +V VL T N G T +H
Sbjct: 240 LC--ERGCDVNLPDAHSD-TPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHH 296
Query: 1172 AAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAP 1230
A+ GH V ++ L + K+ G T LH+AA E + L+
Sbjct: 297 ASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIRE---------- 346
Query: 1231 TGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGG 1290
G V V + +PLHLA + +V LL++ AG + A +E G LH+A
Sbjct: 347 -GRCDVNVRNRKL-QSPLHLAVQQAHVGLVPLLVD-AGCSVN-AEDEEGDTALHVALQRH 402
Query: 1291 H-MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG-QGAEINATDKNGWT 1348
+ +V L R +GL ++ V L +GA+++ T+ G +
Sbjct: 403 QLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRS 462
Query: 1349 PLHCAAKAGHLNVVK 1363
PL AA+ L ++
Sbjct: 463 PLDLAAEGRVLKALQ 477
Score = 75.4 bits (177), Expect = 2e-12
Identities = 47/152 (30%), Positives = 71/152 (46%), Gaps = 4/152 (2%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G+ L +A G ++R LL A+ L G+TALH AA + R+L+ G
Sbjct: 154 QGRTALQVAAYLGQVELIRLLLQARAGVDLP--DDEGNTALHYAALGNQPEATRVLLSAG 211
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMH--LAAENGHAAI 179
DA N T LH+A G +V+ + + D TP+H ++A G + I
Sbjct: 212 CRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGI 271
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHA 211
+E+L + + G TL+H ASL GHA
Sbjct: 272 VEVLTEVPNIDVTATNSQGFTLLHHASLKGHA 303
Score = 69.7 bits (163), Expect = 1e-10
Identities = 47/168 (27%), Positives = 79/168 (47%), Gaps = 5/168 (2%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
DL G L A R LLSA + A TALH+A +R +++ R
Sbjct: 182 DLPDDEGNTALHYAALGNQPEATRVLLSAGC--RADAINSTQSTALHVAVQRGFLEVVRA 239
Query: 117 LVDYGAVVDATNGAGQTPLH--IAAAEGDEPLVKYFYGV-RANAAIADNEDRTPMHLAAE 173
L + G V+ + TPLH I+A G +V+ V + +++ T +H A+
Sbjct: 240 LCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASL 299
Query: 174 NGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
GHA + + + + + + +DG T +H+A+LN H + A +L ++G
Sbjct: 300 KGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREG 347
Score = 68.5 bits (160), Expect = 2e-10
Identities = 83/316 (26%), Positives = 133/316 (42%), Gaps = 36/316 (11%)
Query: 731 ETPLHIAARIPDGDKC-ALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
E P + + G+ AL LL+ G T + VAA G + + LLL+
Sbjct: 121 EHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQ---- 176
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGAS 849
+ V + D G T L A P+ R L+ + DA++ ++
Sbjct: 177 --ARAGVDLPD-DEGNTALHYAALGNQPEATRVLLS----------AGCRADAINSTQST 223
Query: 850 ALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN-DVMTE 908
ALH V + +VV+ L E G DV+L H+ +T H AG + E
Sbjct: 224 ALH---------VAVQRGFLEVVRALCERGCDVNLPDAHS-DTPLHSAISAGTGASGIVE 273
Query: 909 MIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR-VDVFDVEGRSALH 967
++ + DV+ NS G+T L A +GH V +L + VD +G +ALH
Sbjct: 274 VLTEVPNIDVTAT----NSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 329
Query: 968 LAAEHGYLQVCDALL-TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
LAA + + +V L+ + +N + R ++ LHLA + LV L+ D ++
Sbjct: 330 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLV-DAGCSVNAED 388
Query: 1027 LKKQTPLHLAAASGQI 1042
+ T LH+A Q+
Sbjct: 389 EEGDTALHVALQRHQL 404
Score = 54.4 bits (125), Expect = 4e-06
Identities = 41/130 (31%), Positives = 64/130 (49%), Gaps = 5/130 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGES-VDVTTNDNYTALHIAVESCKPAVVETLLGYG-A 720
G +H A+ GH + +L + VD D +TALH+A + V + L+ G
Sbjct: 290 GFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRC 349
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
DV++R ++ ++PLH+A + L L+ +G N E+G T +HVA + L L
Sbjct: 350 DVNVR-NRKLQSPLHLAVQQAHVGLVPL-LVDAGCSVNAEDEEGDTALHVALQRHQLLPL 407
Query: 781 VLLLEDGGDP 790
V GGDP
Sbjct: 408 V-ADGAGGDP 416
Score = 50.0 bits (114), Expect = 9e-05
Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 2/120 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L++ V GN + +LL + EQ+ T G TAL +AA V++ R+L+ A VD
Sbjct: 126 LVVEVALGNAARALDLLRRRP-EQVD-TKNQGRTALQVAAYLGQVELIRLLLQARAGVDL 183
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G T LH AA + A ++ T +H+A + G ++ L ++
Sbjct: 184 PDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCER 243
Score = 48.0 bits (109), Expect = 4e-04
Identities = 36/113 (31%), Positives = 57/113 (50%), Gaps = 4/113 (3%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV-VDATNGAGQ 132
G+ VR++L A+ + + A G TALHLAA ++A+IL+ G V+ N Q
Sbjct: 301 GHALAVRKIL-ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQ 359
Query: 133 TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+PLH+A + LV + D E T +H+A + H ++ L+AD
Sbjct: 360 SPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQR-H-QLLPLVAD 410
Score = 46.0 bits (104), Expect = 0.001
Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 6/169 (3%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH--LAARRRDVDMA 114
D + L +AV+ G +VR L + + DT LH ++A +
Sbjct: 215 DAINSTQSTALHVAVQRGFLEVVRAL--CERGCDVNLPDAHSDTPLHSAISAGTGASGIV 272
Query: 115 RILVDYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAA 172
+L + + V ATN G T LH A+ +G V+ A ED T +HLAA
Sbjct: 273 EVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 332
Query: 173 ENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
N H + ++L + + + R + + +H+A H +L G
Sbjct: 333 LNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 381
Score = 43.2 bits (97), Expect = 0.010
Identities = 34/117 (29%), Positives = 47/117 (40%), Gaps = 2/117 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA G V +I LLQ VD+ ++ TALH A +P LL G
Sbjct: 155 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 214
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
Q T LH+A + + L + G N TP+H A G A+
Sbjct: 215 DAINSTQ-STALHVAVQ-RGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 269
Score = 39.5 bits (88), Expect = 0.13
Identities = 28/109 (25%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVE--SCKPAVVETLLGYGADVHI 724
+H A + HVG++ L+ G SV+ + TALH+A++ P V + G + +
Sbjct: 362 LHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQL 421
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK 773
+ + + L +A + G A L GA + G +P+ +AA+
Sbjct: 422 L-SRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE 469
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/107 (24%), Positives = 45/107 (42%), Gaps = 1/107 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
LL R E + T G+T L +A+ G +++ +LL A ++ D G T LH AA
Sbjct: 141 LLRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 199
Query: 1358 HLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
++L +G + + + A +V+ L + D
Sbjct: 200 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 246
Score = 37.9 bits (84), Expect = 0.39
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 1/76 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H AA LL G D + TALH+AV+ VV L G D
Sbjct: 187 EGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 246
Query: 722 VHIRGGKQRETPLHIA 737
V++ +TPLH A
Sbjct: 247 VNLPDA-HSDTPLHSA 261
>AB097000-1|BAC77353.1| 999|Homo sapiens putative NFkB activating
protein protein.
Length = 999
Score = 108 bits (260), Expect = 2e-22
Identities = 79/250 (31%), Positives = 127/250 (50%), Gaps = 8/250 (3%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G T L +A + G ++L+ LL A VD+ D EG +ALH AA + LL+
Sbjct: 509 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 568
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH--LAAASGQIEVCK 1046
++ TALH+A G+ +V+ L + +++ TPLH ++A +G + +
Sbjct: 569 DAINSTQSTALHVAVQRGFLEVVRALC-ERGCDVNLPDAHSDTPLHSAISAGTGASGIVE 627
Query: 1047 LLLELGANID--ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
+L E+ NID AT+ G +H A+ ++ V+ L + LV A +DG T H+AA
Sbjct: 628 VLTEV-PNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 686
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
+ +V + L++ R V KL +PL LA + H +V +LV AG S E+
Sbjct: 687 LNNHREVAQILIREGRCDVNVRNRKL--QSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEE 744
Query: 1165 GLTAVHLAAE 1174
G TA+H+A +
Sbjct: 745 GDTALHVALQ 754
Score = 101 bits (242), Expect = 3e-20
Identities = 71/249 (28%), Positives = 123/249 (49%), Gaps = 8/249 (3%)
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
+GR+AL +AA G +++ LL +A ++ G TALH AA+ + L+
Sbjct: 508 QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLL-SAGC 566
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA--AQNNYSEVV 1078
D + + T LH+A G +EV + L E G +++ D P+H+A A S +V
Sbjct: 567 RADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIV 626
Query: 1079 QLFLQQHPNL-VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
++ L + PN+ V AT G T H A+++G + +++ R ++ A+ K + T L
Sbjct: 627 EV-LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQ-LVDAK-KEDGFTALH 683
Query: 1138 LAAEGGHADVVRVLVRAG-ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
LAA H +V ++L+R G NR + +HLA + H ++ ++ + +
Sbjct: 684 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 743
Query: 1197 LGLTPLHIA 1205
G T LH+A
Sbjct: 744 EGDTALHVA 752
Score = 96.7 bits (230), Expect = 8e-19
Identities = 72/245 (29%), Positives = 118/245 (48%), Gaps = 17/245 (6%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
T LQ+AA G +++R+L++A A + G TA+H AA V+ S +
Sbjct: 511 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 570
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLH--LA 1251
T LH+A G E VR L E V+L A S TPLH ++
Sbjct: 571 INSTQSTALHVAVQRGFLEVVRALC---------ERGCDVNLPD---AHSD-TPLHSAIS 617
Query: 1252 AYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDR 1311
A G +V +L + A+N G+ LH A GH V +L+R+ +L+ +
Sbjct: 618 AGTGASGIVEVLTEVPNIDV-TATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE 676
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
G T LH+A+ + H ++ ++L+ +G ++N ++ +PLH A + H+ +V LL ++G
Sbjct: 677 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 736
Query: 1371 SPKSE 1375
S +E
Sbjct: 737 SVNAE 741
Score = 94.3 bits (224), Expect = 4e-18
Identities = 86/292 (29%), Positives = 128/292 (43%), Gaps = 20/292 (6%)
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNK 1129
A N + + L L++ P V T G T +AA G V++I L++ R GV ++
Sbjct: 485 ALGNAARALDL-LRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQA-RAGVDLPDDE 541
Query: 1130 LNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT 1189
N T L AA G + RVL+ AG N TA+H+A + G V+ +
Sbjct: 542 GN--TALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC 599
Query: 1190 LRISSKKLGLTPLHIAAYYGQ-AETVRELLSHVPGTVKSEAPTGVSLVPVLGAES-GLTP 1247
TPLH A G A + E+L+ VP + V S G T
Sbjct: 600 DVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN------------IDVTATNSQGFTL 647
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH A+ G+ VR +L A DA E+G+ LHLA H + +L+ ++
Sbjct: 648 LHHASLKGHALAVRKILARARQLVDA-KKEDGFTALHLAALNNHREVAQILIREGRCDVN 706
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
+R ++ LH+A H +V +L+ G +NA D+ G T LH A + L
Sbjct: 707 VRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL 758
Score = 84.2 bits (199), Expect = 4e-15
Identities = 78/250 (31%), Positives = 115/250 (46%), Gaps = 22/250 (8%)
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
A +D G V +A + LD++R ++ +K G T L +AAY GQ E +R
Sbjct: 469 AQKSDPEHPGRLVVEVALGNA-ARALDLLRRRPE-QVDTKNQGRTALQVAAYLGQVELIR 526
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS 1275
LL +A GV L + G T LH AA R+LL SAG +ADA
Sbjct: 527 LLL---------QARAGVDLPD----DEGNTALHYAALGNQPEATRVLL-SAGCRADAI- 571
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH--IASTHGHYQMVEVLL 1333
N LH+A G + +V L R ++ + D H T LH I++ G +VEVL
Sbjct: 572 NSTQSTALHVAVQRGFLEVVRALCERGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLT 630
Query: 1334 G-QGAEINATDKNGWTPLHCAAKAGH-LNVVKLLCESGASPKSETNLNCAPIWFAASENH 1391
++ AT+ G+T LH A+ GH L V K+L + ++ + AA NH
Sbjct: 631 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 690
Query: 1392 NDVLEYLLHK 1401
+V + L+ +
Sbjct: 691 REVAQILIRE 700
Score = 82.6 bits (195), Expect = 1e-14
Identities = 79/275 (28%), Positives = 130/275 (47%), Gaps = 32/275 (11%)
Query: 804 GETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVK 863
G T LQ+A +++R L++ + A +D D++G +ALHYA +
Sbjct: 509 GRTALQVAAYLGQVELIRLLLQ----------ARAGVDLPDDEGNTALHYAALGNQ---- 554
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALN 923
P A R ++ A S Q+ TA H G +V+ + DV N
Sbjct: 555 -PEATRVLLSAGCRADAINSTQS-----TALHVAVQRGFLEVVRALCER--GCDV----N 602
Query: 924 RQNSIGWTPL--LIACHRGHMQLVNTLLTNHARVDVF--DVEGRSALHLAAEHGY-LQVC 978
++ TPL I+ G +V +LT +DV + +G + LH A+ G+ L V
Sbjct: 603 LPDAHSDTPLHSAISAGTGASGIVE-VLTEVPNIDVTATNSQGFTLLHHASLKGHALAVR 661
Query: 979 DALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
L + +++K +G TALHLAA+N + + + LIR+ ++V K Q+PLHLA
Sbjct: 662 KILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQ 721
Query: 1039 SGQIEVCKLLLELGANIDATDELGQKPIHAAAQNN 1073
+ + LL++ G +++A DE G +H A Q +
Sbjct: 722 QAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRH 756
Score = 77.0 bits (181), Expect = 7e-13
Identities = 99/375 (26%), Positives = 162/375 (43%), Gaps = 27/375 (7%)
Query: 995 GRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
GR + +A N L L+R +D + +T L +AA GQ+E+ +LLL+ A
Sbjct: 478 GRLVVEVALGNAARALD--LLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAG 534
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
+D D+ G +H AA N E ++ L A +T H+A +G ++V+
Sbjct: 535 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCR-ADAINSTQSTALHVAVQRGFLEVVRA 593
Query: 1115 LMKFDRTGVISARNKLNDSTPLQ--LAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHL 1171
L +R ++ + +D TPL ++A G + +V VL T N G T +H
Sbjct: 594 LC--ERGCDVNLPDAHSD-TPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHH 650
Query: 1172 AAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAP 1230
A+ GH V ++ L + K+ G T LH+AA E + L+
Sbjct: 651 ASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIRE---------- 700
Query: 1231 TGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGG 1290
G V V + +PLHLA + +V LL++ AG + A +E G LH+A
Sbjct: 701 -GRCDVNVRNRKL-QSPLHLAVQQAHVGLVPLLVD-AGCSVN-AEDEEGDTALHVALQRH 756
Query: 1291 H-MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG-QGAEINATDKNGWT 1348
+ +V L R +GL ++ V L +GA+++ T+ G +
Sbjct: 757 QLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRS 816
Query: 1349 PLHCAAKAGHLNVVK 1363
PL AA+ L ++
Sbjct: 817 PLDLAAEGRVLKALQ 831
Score = 75.4 bits (177), Expect = 2e-12
Identities = 47/152 (30%), Positives = 71/152 (46%), Gaps = 4/152 (2%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G+ L +A G ++R LL A+ L G+TALH AA + R+L+ G
Sbjct: 508 QGRTALQVAAYLGQVELIRLLLQARAGVDLP--DDEGNTALHYAALGNQPEATRVLLSAG 565
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMH--LAAENGHAAI 179
DA N T LH+A G +V+ + + D TP+H ++A G + I
Sbjct: 566 CRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGI 625
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHA 211
+E+L + + G TL+H ASL GHA
Sbjct: 626 VEVLTEVPNIDVTATNSQGFTLLHHASLKGHA 657
Score = 69.7 bits (163), Expect = 1e-10
Identities = 47/168 (27%), Positives = 79/168 (47%), Gaps = 5/168 (2%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
DL G L A R LLSA + A TALH+A +R +++ R
Sbjct: 536 DLPDDEGNTALHYAALGNQPEATRVLLSAGC--RADAINSTQSTALHVAVQRGFLEVVRA 593
Query: 117 LVDYGAVVDATNGAGQTPLH--IAAAEGDEPLVKYFYGV-RANAAIADNEDRTPMHLAAE 173
L + G V+ + TPLH I+A G +V+ V + +++ T +H A+
Sbjct: 594 LCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASL 653
Query: 174 NGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
GHA + + + + + + +DG T +H+A+LN H + A +L ++G
Sbjct: 654 KGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREG 701
Score = 68.5 bits (160), Expect = 2e-10
Identities = 83/316 (26%), Positives = 133/316 (42%), Gaps = 36/316 (11%)
Query: 731 ETPLHIAARIPDGDKC-ALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
E P + + G+ AL LL+ G T + VAA G + + LLL+
Sbjct: 475 EHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQ---- 530
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGAS 849
+ V + D G T L A P+ R L+ + DA++ ++
Sbjct: 531 --ARAGVDLPD-DEGNTALHYAALGNQPEATRVLLS----------AGCRADAINSTQST 577
Query: 850 ALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN-DVMTE 908
ALH V + +VV+ L E G DV+L H+ +T H AG + E
Sbjct: 578 ALH---------VAVQRGFLEVVRALCERGCDVNLPDAHS-DTPLHSAISAGTGASGIVE 627
Query: 909 MIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR-VDVFDVEGRSALH 967
++ + DV+ NS G+T L A +GH V +L + VD +G +ALH
Sbjct: 628 VLTEVPNIDVTAT----NSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 683
Query: 968 LAAEHGYLQVCDALL-TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
LAA + + +V L+ + +N + R ++ LHLA + LV L+ D ++
Sbjct: 684 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLV-DAGCSVNAED 742
Query: 1027 LKKQTPLHLAAASGQI 1042
+ T LH+A Q+
Sbjct: 743 EEGDTALHVALQRHQL 758
Score = 54.4 bits (125), Expect = 4e-06
Identities = 41/130 (31%), Positives = 64/130 (49%), Gaps = 5/130 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGES-VDVTTNDNYTALHIAVESCKPAVVETLLGYG-A 720
G +H A+ GH + +L + VD D +TALH+A + V + L+ G
Sbjct: 644 GFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRC 703
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
DV++R ++ ++PLH+A + L L+ +G N E+G T +HVA + L L
Sbjct: 704 DVNVR-NRKLQSPLHLAVQQAHVGLVPL-LVDAGCSVNAEDEEGDTALHVALQRHQLLPL 761
Query: 781 VLLLEDGGDP 790
V GGDP
Sbjct: 762 V-ADGAGGDP 770
Score = 50.0 bits (114), Expect = 9e-05
Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 2/120 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L++ V GN + +LL + EQ+ T G TAL +AA V++ R+L+ A VD
Sbjct: 480 LVVEVALGNAARALDLLRRRP-EQVD-TKNQGRTALQVAAYLGQVELIRLLLQARAGVDL 537
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G T LH AA + A ++ T +H+A + G ++ L ++
Sbjct: 538 PDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCER 597
Score = 48.0 bits (109), Expect = 4e-04
Identities = 36/113 (31%), Positives = 57/113 (50%), Gaps = 4/113 (3%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV-VDATNGAGQ 132
G+ VR++L A+ + + A G TALHLAA ++A+IL+ G V+ N Q
Sbjct: 655 GHALAVRKIL-ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQ 713
Query: 133 TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+PLH+A + LV + D E T +H+A + H ++ L+AD
Sbjct: 714 SPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQR-H-QLLPLVAD 764
Score = 46.0 bits (104), Expect = 0.001
Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 6/169 (3%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH--LAARRRDVDMA 114
D + L +AV+ G +VR L + + DT LH ++A +
Sbjct: 569 DAINSTQSTALHVAVQRGFLEVVRAL--CERGCDVNLPDAHSDTPLHSAISAGTGASGIV 626
Query: 115 RILVDYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAA 172
+L + + V ATN G T LH A+ +G V+ A ED T +HLAA
Sbjct: 627 EVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 686
Query: 173 ENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
N H + ++L + + + R + + +H+A H +L G
Sbjct: 687 LNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 735
Score = 43.2 bits (97), Expect = 0.010
Identities = 34/117 (29%), Positives = 47/117 (40%), Gaps = 2/117 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA G V +I LLQ VD+ ++ TALH A +P LL G
Sbjct: 509 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 568
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
Q T LH+A + + L + G N TP+H A G A+
Sbjct: 569 DAINSTQ-STALHVAVQ-RGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 623
Score = 39.5 bits (88), Expect = 0.13
Identities = 28/109 (25%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVE--SCKPAVVETLLGYGADVHI 724
+H A + HVG++ L+ G SV+ + TALH+A++ P V + G + +
Sbjct: 716 LHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQL 775
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK 773
+ + + L +A + G A L GA + G +P+ +AA+
Sbjct: 776 L-SRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE 823
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/107 (24%), Positives = 45/107 (42%), Gaps = 1/107 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
LL R E + T G+T L +A+ G +++ +LL A ++ D G T LH AA
Sbjct: 495 LLRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 553
Query: 1358 HLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
++L +G + + + A +V+ L + D
Sbjct: 554 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 600
Score = 37.9 bits (84), Expect = 0.39
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 1/76 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H AA LL G D + TALH+AV+ VV L G D
Sbjct: 541 EGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 600
Query: 722 VHIRGGKQRETPLHIA 737
V++ +TPLH A
Sbjct: 601 VNLPDA-HSDTPLHSA 615
>AB076693-1|BAC00994.1| 1009|Homo sapiens skeletrophin gamma protein.
Length = 1009
Score = 108 bits (260), Expect = 2e-22
Identities = 79/250 (31%), Positives = 127/250 (50%), Gaps = 8/250 (3%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G T L +A + G ++L+ LL A VD+ D EG +ALH AA + LL+
Sbjct: 519 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 578
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH--LAAASGQIEVCK 1046
++ TALH+A G+ +V+ L + +++ TPLH ++A +G + +
Sbjct: 579 DAINSTQSTALHVAVQRGFLEVVRALC-ERGCDVNLPDAHSDTPLHSAISAGTGASGIVE 637
Query: 1047 LLLELGANID--ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
+L E+ NID AT+ G +H A+ ++ V+ L + LV A +DG T H+AA
Sbjct: 638 VLTEV-PNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 696
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
+ +V + L++ R V KL +PL LA + H +V +LV AG S E+
Sbjct: 697 LNNHREVAQILIREGRCDVNVRNRKL--QSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEE 754
Query: 1165 GLTAVHLAAE 1174
G TA+H+A +
Sbjct: 755 GDTALHVALQ 764
Score = 101 bits (242), Expect = 3e-20
Identities = 71/249 (28%), Positives = 123/249 (49%), Gaps = 8/249 (3%)
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
+GR+AL +AA G +++ LL +A ++ G TALH AA+ + L+
Sbjct: 518 QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLL-SAGC 576
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA--AQNNYSEVV 1078
D + + T LH+A G +EV + L E G +++ D P+H+A A S +V
Sbjct: 577 RADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIV 636
Query: 1079 QLFLQQHPNL-VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
++ L + PN+ V AT G T H A+++G + +++ R ++ A+ K + T L
Sbjct: 637 EV-LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQ-LVDAK-KEDGFTALH 693
Query: 1138 LAAEGGHADVVRVLVRAG-ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
LAA H +V ++L+R G NR + +HLA + H ++ ++ + +
Sbjct: 694 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 753
Query: 1197 LGLTPLHIA 1205
G T LH+A
Sbjct: 754 EGDTALHVA 762
Score = 96.7 bits (230), Expect = 8e-19
Identities = 72/245 (29%), Positives = 118/245 (48%), Gaps = 17/245 (6%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
T LQ+AA G +++R+L++A A + G TA+H AA V+ S +
Sbjct: 521 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 580
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLH--LA 1251
T LH+A G E VR L E V+L A S TPLH ++
Sbjct: 581 INSTQSTALHVAVQRGFLEVVRALC---------ERGCDVNLPD---AHSD-TPLHSAIS 627
Query: 1252 AYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDR 1311
A G +V +L + A+N G+ LH A GH V +L+R+ +L+ +
Sbjct: 628 AGTGASGIVEVLTEVPNIDV-TATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE 686
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
G T LH+A+ + H ++ ++L+ +G ++N ++ +PLH A + H+ +V LL ++G
Sbjct: 687 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 746
Query: 1371 SPKSE 1375
S +E
Sbjct: 747 SVNAE 751
Score = 94.3 bits (224), Expect = 4e-18
Identities = 86/292 (29%), Positives = 128/292 (43%), Gaps = 20/292 (6%)
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNK 1129
A N + + L L++ P V T G T +AA G V++I L++ R GV ++
Sbjct: 495 ALGNAARALDL-LRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQA-RAGVDLPDDE 551
Query: 1130 LNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT 1189
N T L AA G + RVL+ AG N TA+H+A + G V+ +
Sbjct: 552 GN--TALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC 609
Query: 1190 LRISSKKLGLTPLHIAAYYGQ-AETVRELLSHVPGTVKSEAPTGVSLVPVLGAES-GLTP 1247
TPLH A G A + E+L+ VP + V S G T
Sbjct: 610 DVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN------------IDVTATNSQGFTL 657
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH A+ G+ VR +L A DA E+G+ LHLA H + +L+ ++
Sbjct: 658 LHHASLKGHALAVRKILARARQLVDA-KKEDGFTALHLAALNNHREVAQILIREGRCDVN 716
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
+R ++ LH+A H +V +L+ G +NA D+ G T LH A + L
Sbjct: 717 VRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL 768
Score = 84.2 bits (199), Expect = 4e-15
Identities = 78/250 (31%), Positives = 115/250 (46%), Gaps = 22/250 (8%)
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
A +D G V +A + LD++R ++ +K G T L +AAY GQ E +R
Sbjct: 479 AQKSDPEHPGRLVVEVALGNA-ARALDLLRRRPE-QVDTKNQGRTALQVAAYLGQVELIR 536
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS 1275
LL +A GV L + G T LH AA R+LL SAG +ADA
Sbjct: 537 LLL---------QARAGVDLPD----DEGNTALHYAALGNQPEATRVLL-SAGCRADAI- 581
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH--IASTHGHYQMVEVLL 1333
N LH+A G + +V L R ++ + D H T LH I++ G +VEVL
Sbjct: 582 NSTQSTALHVAVQRGFLEVVRALCERGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLT 640
Query: 1334 G-QGAEINATDKNGWTPLHCAAKAGH-LNVVKLLCESGASPKSETNLNCAPIWFAASENH 1391
++ AT+ G+T LH A+ GH L V K+L + ++ + AA NH
Sbjct: 641 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 700
Query: 1392 NDVLEYLLHK 1401
+V + L+ +
Sbjct: 701 REVAQILIRE 710
Score = 82.6 bits (195), Expect = 1e-14
Identities = 79/275 (28%), Positives = 130/275 (47%), Gaps = 32/275 (11%)
Query: 804 GETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVK 863
G T LQ+A +++R L++ + A +D D++G +ALHYA +
Sbjct: 519 GRTALQVAAYLGQVELIRLLLQ----------ARAGVDLPDDEGNTALHYAALGNQ---- 564
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALN 923
P A R ++ A S Q+ TA H G +V+ + DV N
Sbjct: 565 -PEATRVLLSAGCRADAINSTQS-----TALHVAVQRGFLEVVRALCER--GCDV----N 612
Query: 924 RQNSIGWTPL--LIACHRGHMQLVNTLLTNHARVDVF--DVEGRSALHLAAEHGY-LQVC 978
++ TPL I+ G +V +LT +DV + +G + LH A+ G+ L V
Sbjct: 613 LPDAHSDTPLHSAISAGTGASGIVE-VLTEVPNIDVTATNSQGFTLLHHASLKGHALAVR 671
Query: 979 DALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
L + +++K +G TALHLAA+N + + + LIR+ ++V K Q+PLHLA
Sbjct: 672 KILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQ 731
Query: 1039 SGQIEVCKLLLELGANIDATDELGQKPIHAAAQNN 1073
+ + LL++ G +++A DE G +H A Q +
Sbjct: 732 QAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRH 766
Score = 77.0 bits (181), Expect = 7e-13
Identities = 99/375 (26%), Positives = 162/375 (43%), Gaps = 27/375 (7%)
Query: 995 GRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
GR + +A N L L+R +D + +T L +AA GQ+E+ +LLL+ A
Sbjct: 488 GRLVVEVALGNAARALD--LLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAG 544
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
+D D+ G +H AA N E ++ L A +T H+A +G ++V+
Sbjct: 545 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCR-ADAINSTQSTALHVAVQRGFLEVVRA 603
Query: 1115 LMKFDRTGVISARNKLNDSTPLQ--LAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHL 1171
L +R ++ + +D TPL ++A G + +V VL T N G T +H
Sbjct: 604 LC--ERGCDVNLPDAHSD-TPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHH 660
Query: 1172 AAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAP 1230
A+ GH V ++ L + K+ G T LH+AA E + L+
Sbjct: 661 ASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIRE---------- 710
Query: 1231 TGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGG 1290
G V V + +PLHLA + +V LL++ AG + A +E G LH+A
Sbjct: 711 -GRCDVNVRNRKL-QSPLHLAVQQAHVGLVPLLVD-AGCSVN-AEDEEGDTALHVALQRH 766
Query: 1291 H-MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG-QGAEINATDKNGWT 1348
+ +V L R +GL ++ V L +GA+++ T+ G +
Sbjct: 767 QLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRS 826
Query: 1349 PLHCAAKAGHLNVVK 1363
PL AA+ L ++
Sbjct: 827 PLDLAAEGRVLKALQ 841
Score = 75.4 bits (177), Expect = 2e-12
Identities = 47/152 (30%), Positives = 71/152 (46%), Gaps = 4/152 (2%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G+ L +A G ++R LL A+ L G+TALH AA + R+L+ G
Sbjct: 518 QGRTALQVAAYLGQVELIRLLLQARAGVDLP--DDEGNTALHYAALGNQPEATRVLLSAG 575
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMH--LAAENGHAAI 179
DA N T LH+A G +V+ + + D TP+H ++A G + I
Sbjct: 576 CRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGI 635
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHA 211
+E+L + + G TL+H ASL GHA
Sbjct: 636 VEVLTEVPNIDVTATNSQGFTLLHHASLKGHA 667
Score = 69.7 bits (163), Expect = 1e-10
Identities = 47/168 (27%), Positives = 79/168 (47%), Gaps = 5/168 (2%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
DL G L A R LLSA + A TALH+A +R +++ R
Sbjct: 546 DLPDDEGNTALHYAALGNQPEATRVLLSAGC--RADAINSTQSTALHVAVQRGFLEVVRA 603
Query: 117 LVDYGAVVDATNGAGQTPLH--IAAAEGDEPLVKYFYGV-RANAAIADNEDRTPMHLAAE 173
L + G V+ + TPLH I+A G +V+ V + +++ T +H A+
Sbjct: 604 LCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASL 663
Query: 174 NGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
GHA + + + + + + +DG T +H+A+LN H + A +L ++G
Sbjct: 664 KGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREG 711
Score = 68.5 bits (160), Expect = 2e-10
Identities = 83/316 (26%), Positives = 133/316 (42%), Gaps = 36/316 (11%)
Query: 731 ETPLHIAARIPDGDKC-ALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
E P + + G+ AL LL+ G T + VAA G + + LLL+
Sbjct: 485 EHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQ---- 540
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGAS 849
+ V + D G T L A P+ R L+ + DA++ ++
Sbjct: 541 --ARAGVDLPD-DEGNTALHYAALGNQPEATRVLLS----------AGCRADAINSTQST 587
Query: 850 ALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN-DVMTE 908
ALH V + +VV+ L E G DV+L H+ +T H AG + E
Sbjct: 588 ALH---------VAVQRGFLEVVRALCERGCDVNLPDAHS-DTPLHSAISAGTGASGIVE 637
Query: 909 MIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR-VDVFDVEGRSALH 967
++ + DV+ NS G+T L A +GH V +L + VD +G +ALH
Sbjct: 638 VLTEVPNIDVTAT----NSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 693
Query: 968 LAAEHGYLQVCDALL-TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
LAA + + +V L+ + +N + R ++ LHLA + LV L+ D ++
Sbjct: 694 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLV-DAGCSVNAED 752
Query: 1027 LKKQTPLHLAAASGQI 1042
+ T LH+A Q+
Sbjct: 753 EEGDTALHVALQRHQL 768
Score = 54.4 bits (125), Expect = 4e-06
Identities = 41/130 (31%), Positives = 64/130 (49%), Gaps = 5/130 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGES-VDVTTNDNYTALHIAVESCKPAVVETLLGYG-A 720
G +H A+ GH + +L + VD D +TALH+A + V + L+ G
Sbjct: 654 GFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRC 713
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
DV++R ++ ++PLH+A + L L+ +G N E+G T +HVA + L L
Sbjct: 714 DVNVR-NRKLQSPLHLAVQQAHVGLVPL-LVDAGCSVNAEDEEGDTALHVALQRHQLLPL 771
Query: 781 VLLLEDGGDP 790
V GGDP
Sbjct: 772 V-ADGAGGDP 780
Score = 50.0 bits (114), Expect = 9e-05
Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 2/120 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L++ V GN + +LL + EQ+ T G TAL +AA V++ R+L+ A VD
Sbjct: 490 LVVEVALGNAARALDLLRRRP-EQVD-TKNQGRTALQVAAYLGQVELIRLLLQARAGVDL 547
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G T LH AA + A ++ T +H+A + G ++ L ++
Sbjct: 548 PDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCER 607
Score = 48.0 bits (109), Expect = 4e-04
Identities = 36/113 (31%), Positives = 57/113 (50%), Gaps = 4/113 (3%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV-VDATNGAGQ 132
G+ VR++L A+ + + A G TALHLAA ++A+IL+ G V+ N Q
Sbjct: 665 GHALAVRKIL-ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQ 723
Query: 133 TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+PLH+A + LV + D E T +H+A + H ++ L+AD
Sbjct: 724 SPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQR-H-QLLPLVAD 774
Score = 46.0 bits (104), Expect = 0.001
Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 6/169 (3%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH--LAARRRDVDMA 114
D + L +AV+ G +VR L + + DT LH ++A +
Sbjct: 579 DAINSTQSTALHVAVQRGFLEVVRAL--CERGCDVNLPDAHSDTPLHSAISAGTGASGIV 636
Query: 115 RILVDYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAA 172
+L + + V ATN G T LH A+ +G V+ A ED T +HLAA
Sbjct: 637 EVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 696
Query: 173 ENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
N H + ++L + + + R + + +H+A H +L G
Sbjct: 697 LNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 745
Score = 43.2 bits (97), Expect = 0.010
Identities = 34/117 (29%), Positives = 47/117 (40%), Gaps = 2/117 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA G V +I LLQ VD+ ++ TALH A +P LL G
Sbjct: 519 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 578
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
Q T LH+A + + L + G N TP+H A G A+
Sbjct: 579 DAINSTQ-STALHVAVQ-RGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 633
Score = 39.5 bits (88), Expect = 0.13
Identities = 28/109 (25%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVE--SCKPAVVETLLGYGADVHI 724
+H A + HVG++ L+ G SV+ + TALH+A++ P V + G + +
Sbjct: 726 LHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQL 785
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK 773
+ + + L +A + G A L GA + G +P+ +AA+
Sbjct: 786 L-SRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE 833
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/107 (24%), Positives = 45/107 (42%), Gaps = 1/107 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
LL R E + T G+T L +A+ G +++ +LL A ++ D G T LH AA
Sbjct: 505 LLRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 563
Query: 1358 HLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
++L +G + + + A +V+ L + D
Sbjct: 564 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 610
Score = 37.9 bits (84), Expect = 0.39
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 1/76 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H AA LL G D + TALH+AV+ VV L G D
Sbjct: 551 EGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 610
Query: 722 VHIRGGKQRETPLHIA 737
V++ +TPLH A
Sbjct: 611 VNLPDA-HSDTPLHSA 625
>AB076692-1|BAC00993.1| 948|Homo sapiens skeletrophin beta protein.
Length = 948
Score = 108 bits (260), Expect = 2e-22
Identities = 79/250 (31%), Positives = 127/250 (50%), Gaps = 8/250 (3%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G T L +A + G ++L+ LL A VD+ D EG +ALH AA + LL+
Sbjct: 458 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 517
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH--LAAASGQIEVCK 1046
++ TALH+A G+ +V+ L + +++ TPLH ++A +G + +
Sbjct: 518 DAINSTQSTALHVAVQRGFLEVVRALC-ERGCDVNLPDAHSDTPLHSAISAGTGASGIVE 576
Query: 1047 LLLELGANID--ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
+L E+ NID AT+ G +H A+ ++ V+ L + LV A +DG T H+AA
Sbjct: 577 VLTEV-PNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 635
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
+ +V + L++ R V KL +PL LA + H +V +LV AG S E+
Sbjct: 636 LNNHREVAQILIREGRCDVNVRNRKL--QSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEE 693
Query: 1165 GLTAVHLAAE 1174
G TA+H+A +
Sbjct: 694 GDTALHVALQ 703
Score = 101 bits (242), Expect = 3e-20
Identities = 71/249 (28%), Positives = 123/249 (49%), Gaps = 8/249 (3%)
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
+GR+AL +AA G +++ LL +A ++ G TALH AA+ + L+
Sbjct: 457 QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLL-SAGC 515
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA--AQNNYSEVV 1078
D + + T LH+A G +EV + L E G +++ D P+H+A A S +V
Sbjct: 516 RADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIV 575
Query: 1079 QLFLQQHPNL-VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
++ L + PN+ V AT G T H A+++G + +++ R ++ A+ K + T L
Sbjct: 576 EV-LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQ-LVDAK-KEDGFTALH 632
Query: 1138 LAAEGGHADVVRVLVRAG-ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
LAA H +V ++L+R G NR + +HLA + H ++ ++ + +
Sbjct: 633 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 692
Query: 1197 LGLTPLHIA 1205
G T LH+A
Sbjct: 693 EGDTALHVA 701
Score = 96.7 bits (230), Expect = 8e-19
Identities = 72/245 (29%), Positives = 118/245 (48%), Gaps = 17/245 (6%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
T LQ+AA G +++R+L++A A + G TA+H AA V+ S +
Sbjct: 460 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 519
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLH--LA 1251
T LH+A G E VR L E V+L A S TPLH ++
Sbjct: 520 INSTQSTALHVAVQRGFLEVVRALC---------ERGCDVNLPD---AHSD-TPLHSAIS 566
Query: 1252 AYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDR 1311
A G +V +L + A+N G+ LH A GH V +L+R+ +L+ +
Sbjct: 567 AGTGASGIVEVLTEVPNIDV-TATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE 625
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
G T LH+A+ + H ++ ++L+ +G ++N ++ +PLH A + H+ +V LL ++G
Sbjct: 626 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 685
Query: 1371 SPKSE 1375
S +E
Sbjct: 686 SVNAE 690
Score = 94.3 bits (224), Expect = 4e-18
Identities = 86/292 (29%), Positives = 128/292 (43%), Gaps = 20/292 (6%)
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNK 1129
A N + + L L++ P V T G T +AA G V++I L++ R GV ++
Sbjct: 434 ALGNAARALDL-LRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQA-RAGVDLPDDE 490
Query: 1130 LNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT 1189
N T L AA G + RVL+ AG N TA+H+A + G V+ +
Sbjct: 491 GN--TALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC 548
Query: 1190 LRISSKKLGLTPLHIAAYYGQ-AETVRELLSHVPGTVKSEAPTGVSLVPVLGAES-GLTP 1247
TPLH A G A + E+L+ VP + V S G T
Sbjct: 549 DVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN------------IDVTATNSQGFTL 596
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH A+ G+ VR +L A DA E+G+ LHLA H + +L+ ++
Sbjct: 597 LHHASLKGHALAVRKILARARQLVDA-KKEDGFTALHLAALNNHREVAQILIREGRCDVN 655
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
+R ++ LH+A H +V +L+ G +NA D+ G T LH A + L
Sbjct: 656 VRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL 707
Score = 84.2 bits (199), Expect = 4e-15
Identities = 78/250 (31%), Positives = 115/250 (46%), Gaps = 22/250 (8%)
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
A +D G V +A + LD++R ++ +K G T L +AAY GQ E +R
Sbjct: 418 AQKSDPEHPGRLVVEVALGNA-ARALDLLRRRPE-QVDTKNQGRTALQVAAYLGQVELIR 475
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS 1275
LL +A GV L + G T LH AA R+LL SAG +ADA
Sbjct: 476 LLL---------QARAGVDLPD----DEGNTALHYAALGNQPEATRVLL-SAGCRADAI- 520
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH--IASTHGHYQMVEVLL 1333
N LH+A G + +V L R ++ + D H T LH I++ G +VEVL
Sbjct: 521 NSTQSTALHVAVQRGFLEVVRALCERGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLT 579
Query: 1334 G-QGAEINATDKNGWTPLHCAAKAGH-LNVVKLLCESGASPKSETNLNCAPIWFAASENH 1391
++ AT+ G+T LH A+ GH L V K+L + ++ + AA NH
Sbjct: 580 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 639
Query: 1392 NDVLEYLLHK 1401
+V + L+ +
Sbjct: 640 REVAQILIRE 649
Score = 82.6 bits (195), Expect = 1e-14
Identities = 79/275 (28%), Positives = 130/275 (47%), Gaps = 32/275 (11%)
Query: 804 GETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVK 863
G T LQ+A +++R L++ + A +D D++G +ALHYA +
Sbjct: 458 GRTALQVAAYLGQVELIRLLLQ----------ARAGVDLPDDEGNTALHYAALGNQ---- 503
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALN 923
P A R ++ A S Q+ TA H G +V+ + DV N
Sbjct: 504 -PEATRVLLSAGCRADAINSTQS-----TALHVAVQRGFLEVVRALCER--GCDV----N 551
Query: 924 RQNSIGWTPL--LIACHRGHMQLVNTLLTNHARVDVF--DVEGRSALHLAAEHGY-LQVC 978
++ TPL I+ G +V +LT +DV + +G + LH A+ G+ L V
Sbjct: 552 LPDAHSDTPLHSAISAGTGASGIVE-VLTEVPNIDVTATNSQGFTLLHHASLKGHALAVR 610
Query: 979 DALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
L + +++K +G TALHLAA+N + + + LIR+ ++V K Q+PLHLA
Sbjct: 611 KILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQ 670
Query: 1039 SGQIEVCKLLLELGANIDATDELGQKPIHAAAQNN 1073
+ + LL++ G +++A DE G +H A Q +
Sbjct: 671 QAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRH 705
Score = 77.0 bits (181), Expect = 7e-13
Identities = 99/375 (26%), Positives = 162/375 (43%), Gaps = 27/375 (7%)
Query: 995 GRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
GR + +A N L L+R +D + +T L +AA GQ+E+ +LLL+ A
Sbjct: 427 GRLVVEVALGNAARALD--LLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAG 483
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
+D D+ G +H AA N E ++ L A +T H+A +G ++V+
Sbjct: 484 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCR-ADAINSTQSTALHVAVQRGFLEVVRA 542
Query: 1115 LMKFDRTGVISARNKLNDSTPLQ--LAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHL 1171
L +R ++ + +D TPL ++A G + +V VL T N G T +H
Sbjct: 543 LC--ERGCDVNLPDAHSD-TPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHH 599
Query: 1172 AAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAP 1230
A+ GH V ++ L + K+ G T LH+AA E + L+
Sbjct: 600 ASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIRE---------- 649
Query: 1231 TGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGG 1290
G V V + +PLHLA + +V LL++ AG + A +E G LH+A
Sbjct: 650 -GRCDVNVRNRKL-QSPLHLAVQQAHVGLVPLLVD-AGCSVN-AEDEEGDTALHVALQRH 705
Query: 1291 H-MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG-QGAEINATDKNGWT 1348
+ +V L R +GL ++ V L +GA+++ T+ G +
Sbjct: 706 QLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRS 765
Query: 1349 PLHCAAKAGHLNVVK 1363
PL AA+ L ++
Sbjct: 766 PLDLAAEGRVLKALQ 780
Score = 75.4 bits (177), Expect = 2e-12
Identities = 47/152 (30%), Positives = 71/152 (46%), Gaps = 4/152 (2%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G+ L +A G ++R LL A+ L G+TALH AA + R+L+ G
Sbjct: 457 QGRTALQVAAYLGQVELIRLLLQARAGVDLP--DDEGNTALHYAALGNQPEATRVLLSAG 514
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMH--LAAENGHAAI 179
DA N T LH+A G +V+ + + D TP+H ++A G + I
Sbjct: 515 CRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGI 574
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHA 211
+E+L + + G TL+H ASL GHA
Sbjct: 575 VEVLTEVPNIDVTATNSQGFTLLHHASLKGHA 606
Score = 69.7 bits (163), Expect = 1e-10
Identities = 47/168 (27%), Positives = 79/168 (47%), Gaps = 5/168 (2%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
DL G L A R LLSA + A TALH+A +R +++ R
Sbjct: 485 DLPDDEGNTALHYAALGNQPEATRVLLSAGC--RADAINSTQSTALHVAVQRGFLEVVRA 542
Query: 117 LVDYGAVVDATNGAGQTPLH--IAAAEGDEPLVKYFYGV-RANAAIADNEDRTPMHLAAE 173
L + G V+ + TPLH I+A G +V+ V + +++ T +H A+
Sbjct: 543 LCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASL 602
Query: 174 NGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
GHA + + + + + + +DG T +H+A+LN H + A +L ++G
Sbjct: 603 KGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREG 650
Score = 68.5 bits (160), Expect = 2e-10
Identities = 83/316 (26%), Positives = 133/316 (42%), Gaps = 36/316 (11%)
Query: 731 ETPLHIAARIPDGDKC-ALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
E P + + G+ AL LL+ G T + VAA G + + LLL+
Sbjct: 424 EHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQ---- 479
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGAS 849
+ V + D G T L A P+ R L+ + DA++ ++
Sbjct: 480 --ARAGVDLPD-DEGNTALHYAALGNQPEATRVLLS----------AGCRADAINSTQST 526
Query: 850 ALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN-DVMTE 908
ALH V + +VV+ L E G DV+L H+ +T H AG + E
Sbjct: 527 ALH---------VAVQRGFLEVVRALCERGCDVNLPDAHS-DTPLHSAISAGTGASGIVE 576
Query: 909 MIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR-VDVFDVEGRSALH 967
++ + DV+ NS G+T L A +GH V +L + VD +G +ALH
Sbjct: 577 VLTEVPNIDVTAT----NSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 632
Query: 968 LAAEHGYLQVCDALL-TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
LAA + + +V L+ + +N + R ++ LHLA + LV L+ D ++
Sbjct: 633 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLV-DAGCSVNAED 691
Query: 1027 LKKQTPLHLAAASGQI 1042
+ T LH+A Q+
Sbjct: 692 EEGDTALHVALQRHQL 707
Score = 54.4 bits (125), Expect = 4e-06
Identities = 41/130 (31%), Positives = 64/130 (49%), Gaps = 5/130 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGES-VDVTTNDNYTALHIAVESCKPAVVETLLGYG-A 720
G +H A+ GH + +L + VD D +TALH+A + V + L+ G
Sbjct: 593 GFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRC 652
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
DV++R ++ ++PLH+A + L L+ +G N E+G T +HVA + L L
Sbjct: 653 DVNVR-NRKLQSPLHLAVQQAHVGLVPL-LVDAGCSVNAEDEEGDTALHVALQRHQLLPL 710
Query: 781 VLLLEDGGDP 790
V GGDP
Sbjct: 711 V-ADGAGGDP 719
Score = 50.0 bits (114), Expect = 9e-05
Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 2/120 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L++ V GN + +LL + EQ+ T G TAL +AA V++ R+L+ A VD
Sbjct: 429 LVVEVALGNAARALDLLRRRP-EQVD-TKNQGRTALQVAAYLGQVELIRLLLQARAGVDL 486
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G T LH AA + A ++ T +H+A + G ++ L ++
Sbjct: 487 PDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCER 546
Score = 48.0 bits (109), Expect = 4e-04
Identities = 36/113 (31%), Positives = 57/113 (50%), Gaps = 4/113 (3%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV-VDATNGAGQ 132
G+ VR++L A+ + + A G TALHLAA ++A+IL+ G V+ N Q
Sbjct: 604 GHALAVRKIL-ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQ 662
Query: 133 TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+PLH+A + LV + D E T +H+A + H ++ L+AD
Sbjct: 663 SPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQR-H-QLLPLVAD 713
Score = 46.0 bits (104), Expect = 0.001
Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 6/169 (3%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH--LAARRRDVDMA 114
D + L +AV+ G +VR L + + DT LH ++A +
Sbjct: 518 DAINSTQSTALHVAVQRGFLEVVRAL--CERGCDVNLPDAHSDTPLHSAISAGTGASGIV 575
Query: 115 RILVDYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAA 172
+L + + V ATN G T LH A+ +G V+ A ED T +HLAA
Sbjct: 576 EVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 635
Query: 173 ENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
N H + ++L + + + R + + +H+A H +L G
Sbjct: 636 LNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 684
Score = 43.2 bits (97), Expect = 0.010
Identities = 34/117 (29%), Positives = 47/117 (40%), Gaps = 2/117 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA G V +I LLQ VD+ ++ TALH A +P LL G
Sbjct: 458 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 517
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
Q T LH+A + + L + G N TP+H A G A+
Sbjct: 518 DAINSTQ-STALHVAVQ-RGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 572
Score = 39.5 bits (88), Expect = 0.13
Identities = 28/109 (25%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVE--SCKPAVVETLLGYGADVHI 724
+H A + HVG++ L+ G SV+ + TALH+A++ P V + G + +
Sbjct: 665 LHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQL 724
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK 773
+ + + L +A + G A L GA + G +P+ +AA+
Sbjct: 725 L-SRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE 772
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/107 (24%), Positives = 45/107 (42%), Gaps = 1/107 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
LL R E + T G+T L +A+ G +++ +LL A ++ D G T LH AA
Sbjct: 444 LLRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 502
Query: 1358 HLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
++L +G + + + A +V+ L + D
Sbjct: 503 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 549
Score = 37.9 bits (84), Expect = 0.39
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 1/76 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H AA LL G D + TALH+AV+ VV L G D
Sbjct: 490 EGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 549
Query: 722 VHIRGGKQRETPLHIA 737
V++ +TPLH A
Sbjct: 550 VNLPDA-HSDTPLHSA 564
>AB076691-1|BAC00992.1| 999|Homo sapiens skeletrophin alpha protein.
Length = 999
Score = 108 bits (260), Expect = 2e-22
Identities = 79/250 (31%), Positives = 127/250 (50%), Gaps = 8/250 (3%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G T L +A + G ++L+ LL A VD+ D EG +ALH AA + LL+
Sbjct: 509 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 568
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH--LAAASGQIEVCK 1046
++ TALH+A G+ +V+ L + +++ TPLH ++A +G + +
Sbjct: 569 DAINSTQSTALHVAVQRGFLEVVRALC-ERGCDVNLPDAHSDTPLHSAISAGTGASGIVE 627
Query: 1047 LLLELGANID--ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
+L E+ NID AT+ G +H A+ ++ V+ L + LV A +DG T H+AA
Sbjct: 628 VLTEV-PNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 686
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
+ +V + L++ R V KL +PL LA + H +V +LV AG S E+
Sbjct: 687 LNNHREVAQILIREGRCDVNVRNRKL--QSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEE 744
Query: 1165 GLTAVHLAAE 1174
G TA+H+A +
Sbjct: 745 GDTALHVALQ 754
Score = 101 bits (242), Expect = 3e-20
Identities = 71/249 (28%), Positives = 123/249 (49%), Gaps = 8/249 (3%)
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
+GR+AL +AA G +++ LL +A ++ G TALH AA+ + L+
Sbjct: 508 QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLL-SAGC 566
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA--AQNNYSEVV 1078
D + + T LH+A G +EV + L E G +++ D P+H+A A S +V
Sbjct: 567 RADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIV 626
Query: 1079 QLFLQQHPNL-VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
++ L + PN+ V AT G T H A+++G + +++ R ++ A+ K + T L
Sbjct: 627 EV-LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQ-LVDAK-KEDGFTALH 683
Query: 1138 LAAEGGHADVVRVLVRAG-ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
LAA H +V ++L+R G NR + +HLA + H ++ ++ + +
Sbjct: 684 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 743
Query: 1197 LGLTPLHIA 1205
G T LH+A
Sbjct: 744 EGDTALHVA 752
Score = 96.7 bits (230), Expect = 8e-19
Identities = 72/245 (29%), Positives = 118/245 (48%), Gaps = 17/245 (6%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
T LQ+AA G +++R+L++A A + G TA+H AA V+ S +
Sbjct: 511 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 570
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLH--LA 1251
T LH+A G E VR L E V+L A S TPLH ++
Sbjct: 571 INSTQSTALHVAVQRGFLEVVRALC---------ERGCDVNLPD---AHSD-TPLHSAIS 617
Query: 1252 AYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDR 1311
A G +V +L + A+N G+ LH A GH V +L+R+ +L+ +
Sbjct: 618 AGTGASGIVEVLTEVPNIDV-TATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE 676
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
G T LH+A+ + H ++ ++L+ +G ++N ++ +PLH A + H+ +V LL ++G
Sbjct: 677 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 736
Query: 1371 SPKSE 1375
S +E
Sbjct: 737 SVNAE 741
Score = 94.3 bits (224), Expect = 4e-18
Identities = 86/292 (29%), Positives = 128/292 (43%), Gaps = 20/292 (6%)
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNK 1129
A N + + L L++ P V T G T +AA G V++I L++ R GV ++
Sbjct: 485 ALGNAARALDL-LRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQA-RAGVDLPDDE 541
Query: 1130 LNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT 1189
N T L AA G + RVL+ AG N TA+H+A + G V+ +
Sbjct: 542 GN--TALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC 599
Query: 1190 LRISSKKLGLTPLHIAAYYGQ-AETVRELLSHVPGTVKSEAPTGVSLVPVLGAES-GLTP 1247
TPLH A G A + E+L+ VP + V S G T
Sbjct: 600 DVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN------------IDVTATNSQGFTL 647
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH A+ G+ VR +L A DA E+G+ LHLA H + +L+ ++
Sbjct: 648 LHHASLKGHALAVRKILARARQLVDA-KKEDGFTALHLAALNNHREVAQILIREGRCDVN 706
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
+R ++ LH+A H +V +L+ G +NA D+ G T LH A + L
Sbjct: 707 VRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL 758
Score = 84.2 bits (199), Expect = 4e-15
Identities = 78/250 (31%), Positives = 115/250 (46%), Gaps = 22/250 (8%)
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
A +D G V +A + LD++R ++ +K G T L +AAY GQ E +R
Sbjct: 469 AQKSDPEHPGRLVVEVALGNA-ARALDLLRRRPE-QVDTKNQGRTALQVAAYLGQVELIR 526
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS 1275
LL +A GV L + G T LH AA R+LL SAG +ADA
Sbjct: 527 LLL---------QARAGVDLPD----DEGNTALHYAALGNQPEATRVLL-SAGCRADAI- 571
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH--IASTHGHYQMVEVLL 1333
N LH+A G + +V L R ++ + D H T LH I++ G +VEVL
Sbjct: 572 NSTQSTALHVAVQRGFLEVVRALCERGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLT 630
Query: 1334 G-QGAEINATDKNGWTPLHCAAKAGH-LNVVKLLCESGASPKSETNLNCAPIWFAASENH 1391
++ AT+ G+T LH A+ GH L V K+L + ++ + AA NH
Sbjct: 631 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 690
Query: 1392 NDVLEYLLHK 1401
+V + L+ +
Sbjct: 691 REVAQILIRE 700
Score = 82.6 bits (195), Expect = 1e-14
Identities = 79/275 (28%), Positives = 130/275 (47%), Gaps = 32/275 (11%)
Query: 804 GETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVK 863
G T LQ+A +++R L++ + A +D D++G +ALHYA +
Sbjct: 509 GRTALQVAAYLGQVELIRLLLQ----------ARAGVDLPDDEGNTALHYAALGNQ---- 554
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALN 923
P A R ++ A S Q+ TA H G +V+ + DV N
Sbjct: 555 -PEATRVLLSAGCRADAINSTQS-----TALHVAVQRGFLEVVRALCER--GCDV----N 602
Query: 924 RQNSIGWTPL--LIACHRGHMQLVNTLLTNHARVDVF--DVEGRSALHLAAEHGY-LQVC 978
++ TPL I+ G +V +LT +DV + +G + LH A+ G+ L V
Sbjct: 603 LPDAHSDTPLHSAISAGTGASGIVE-VLTEVPNIDVTATNSQGFTLLHHASLKGHALAVR 661
Query: 979 DALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
L + +++K +G TALHLAA+N + + + LIR+ ++V K Q+PLHLA
Sbjct: 662 KILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQ 721
Query: 1039 SGQIEVCKLLLELGANIDATDELGQKPIHAAAQNN 1073
+ + LL++ G +++A DE G +H A Q +
Sbjct: 722 QAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRH 756
Score = 77.0 bits (181), Expect = 7e-13
Identities = 99/375 (26%), Positives = 162/375 (43%), Gaps = 27/375 (7%)
Query: 995 GRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
GR + +A N L L+R +D + +T L +AA GQ+E+ +LLL+ A
Sbjct: 478 GRLVVEVALGNAARALD--LLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAG 534
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
+D D+ G +H AA N E ++ L A +T H+A +G ++V+
Sbjct: 535 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCR-ADAINSTQSTALHVAVQRGFLEVVRA 593
Query: 1115 LMKFDRTGVISARNKLNDSTPLQ--LAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHL 1171
L +R ++ + +D TPL ++A G + +V VL T N G T +H
Sbjct: 594 LC--ERGCDVNLPDAHSD-TPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHH 650
Query: 1172 AAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAP 1230
A+ GH V ++ L + K+ G T LH+AA E + L+
Sbjct: 651 ASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIRE---------- 700
Query: 1231 TGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGG 1290
G V V + +PLHLA + +V LL++ AG + A +E G LH+A
Sbjct: 701 -GRCDVNVRNRKL-QSPLHLAVQQAHVGLVPLLVD-AGCSVN-AEDEEGDTALHVALQRH 756
Query: 1291 H-MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG-QGAEINATDKNGWT 1348
+ +V L R +GL ++ V L +GA+++ T+ G +
Sbjct: 757 QLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRS 816
Query: 1349 PLHCAAKAGHLNVVK 1363
PL AA+ L ++
Sbjct: 817 PLDLAAEGRVLKALQ 831
Score = 75.4 bits (177), Expect = 2e-12
Identities = 47/152 (30%), Positives = 71/152 (46%), Gaps = 4/152 (2%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G+ L +A G ++R LL A+ L G+TALH AA + R+L+ G
Sbjct: 508 QGRTALQVAAYLGQVELIRLLLQARAGVDLP--DDEGNTALHYAALGNQPEATRVLLSAG 565
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMH--LAAENGHAAI 179
DA N T LH+A G +V+ + + D TP+H ++A G + I
Sbjct: 566 CRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGI 625
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHA 211
+E+L + + G TL+H ASL GHA
Sbjct: 626 VEVLTEVPNIDVTATNSQGFTLLHHASLKGHA 657
Score = 69.7 bits (163), Expect = 1e-10
Identities = 47/168 (27%), Positives = 79/168 (47%), Gaps = 5/168 (2%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
DL G L A R LLSA + A TALH+A +R +++ R
Sbjct: 536 DLPDDEGNTALHYAALGNQPEATRVLLSAGC--RADAINSTQSTALHVAVQRGFLEVVRA 593
Query: 117 LVDYGAVVDATNGAGQTPLH--IAAAEGDEPLVKYFYGV-RANAAIADNEDRTPMHLAAE 173
L + G V+ + TPLH I+A G +V+ V + +++ T +H A+
Sbjct: 594 LCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASL 653
Query: 174 NGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
GHA + + + + + + +DG T +H+A+LN H + A +L ++G
Sbjct: 654 KGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREG 701
Score = 68.5 bits (160), Expect = 2e-10
Identities = 83/316 (26%), Positives = 133/316 (42%), Gaps = 36/316 (11%)
Query: 731 ETPLHIAARIPDGDKC-ALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
E P + + G+ AL LL+ G T + VAA G + + LLL+
Sbjct: 475 EHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQ---- 530
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGAS 849
+ V + D G T L A P+ R L+ + DA++ ++
Sbjct: 531 --ARAGVDLPD-DEGNTALHYAALGNQPEATRVLLS----------AGCRADAINSTQST 577
Query: 850 ALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN-DVMTE 908
ALH V + +VV+ L E G DV+L H+ +T H AG + E
Sbjct: 578 ALH---------VAVQRGFLEVVRALCERGCDVNLPDAHS-DTPLHSAISAGTGASGIVE 627
Query: 909 MIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR-VDVFDVEGRSALH 967
++ + DV+ NS G+T L A +GH V +L + VD +G +ALH
Sbjct: 628 VLTEVPNIDVTAT----NSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 683
Query: 968 LAAEHGYLQVCDALL-TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
LAA + + +V L+ + +N + R ++ LHLA + LV L+ D ++
Sbjct: 684 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLV-DAGCSVNAED 742
Query: 1027 LKKQTPLHLAAASGQI 1042
+ T LH+A Q+
Sbjct: 743 EEGDTALHVALQRHQL 758
Score = 54.4 bits (125), Expect = 4e-06
Identities = 41/130 (31%), Positives = 64/130 (49%), Gaps = 5/130 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGES-VDVTTNDNYTALHIAVESCKPAVVETLLGYG-A 720
G +H A+ GH + +L + VD D +TALH+A + V + L+ G
Sbjct: 644 GFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRC 703
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
DV++R ++ ++PLH+A + L L+ +G N E+G T +HVA + L L
Sbjct: 704 DVNVR-NRKLQSPLHLAVQQAHVGLVPL-LVDAGCSVNAEDEEGDTALHVALQRHQLLPL 761
Query: 781 VLLLEDGGDP 790
V GGDP
Sbjct: 762 V-ADGAGGDP 770
Score = 50.0 bits (114), Expect = 9e-05
Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 2/120 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L++ V GN + +LL + EQ+ T G TAL +AA V++ R+L+ A VD
Sbjct: 480 LVVEVALGNAARALDLLRRRP-EQVD-TKNQGRTALQVAAYLGQVELIRLLLQARAGVDL 537
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G T LH AA + A ++ T +H+A + G ++ L ++
Sbjct: 538 PDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCER 597
Score = 48.0 bits (109), Expect = 4e-04
Identities = 36/113 (31%), Positives = 57/113 (50%), Gaps = 4/113 (3%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV-VDATNGAGQ 132
G+ VR++L A+ + + A G TALHLAA ++A+IL+ G V+ N Q
Sbjct: 655 GHALAVRKIL-ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQ 713
Query: 133 TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+PLH+A + LV + D E T +H+A + H ++ L+AD
Sbjct: 714 SPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQR-H-QLLPLVAD 764
Score = 46.0 bits (104), Expect = 0.001
Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 6/169 (3%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH--LAARRRDVDMA 114
D + L +AV+ G +VR L + + DT LH ++A +
Sbjct: 569 DAINSTQSTALHVAVQRGFLEVVRAL--CERGCDVNLPDAHSDTPLHSAISAGTGASGIV 626
Query: 115 RILVDYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAA 172
+L + + V ATN G T LH A+ +G V+ A ED T +HLAA
Sbjct: 627 EVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 686
Query: 173 ENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
N H + ++L + + + R + + +H+A H +L G
Sbjct: 687 LNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 735
Score = 43.2 bits (97), Expect = 0.010
Identities = 34/117 (29%), Positives = 47/117 (40%), Gaps = 2/117 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA G V +I LLQ VD+ ++ TALH A +P LL G
Sbjct: 509 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 568
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
Q T LH+A + + L + G N TP+H A G A+
Sbjct: 569 DAINSTQ-STALHVAVQ-RGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 623
Score = 39.5 bits (88), Expect = 0.13
Identities = 28/109 (25%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVE--SCKPAVVETLLGYGADVHI 724
+H A + HVG++ L+ G SV+ + TALH+A++ P V + G + +
Sbjct: 716 LHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQL 775
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK 773
+ + + L +A + G A L GA + G +P+ +AA+
Sbjct: 776 L-SRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE 823
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/107 (24%), Positives = 45/107 (42%), Gaps = 1/107 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
LL R E + T G+T L +A+ G +++ +LL A ++ D G T LH AA
Sbjct: 495 LLRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 553
Query: 1358 HLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
++L +G + + + A +V+ L + D
Sbjct: 554 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 600
Score = 37.9 bits (84), Expect = 0.39
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 1/76 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H AA LL G D + TALH+AV+ VV L G D
Sbjct: 541 EGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 600
Query: 722 VHIRGGKQRETPLHIA 737
V++ +TPLH A
Sbjct: 601 VNLPDA-HSDTPLHSA 615
>AB074480-1|BAB92950.1| 1013|Homo sapiens skeletrophin protein.
Length = 1013
Score = 108 bits (260), Expect = 2e-22
Identities = 79/250 (31%), Positives = 127/250 (50%), Gaps = 8/250 (3%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G T L +A + G ++L+ LL A VD+ D EG +ALH AA + LL+
Sbjct: 523 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 582
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH--LAAASGQIEVCK 1046
++ TALH+A G+ +V+ L + +++ TPLH ++A +G + +
Sbjct: 583 DAINSTQSTALHVAVQRGFLEVVRALC-ERGCDVNLPDAHSDTPLHSAISAGTGASGIVE 641
Query: 1047 LLLELGANID--ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
+L E+ NID AT+ G +H A+ ++ V+ L + LV A +DG T H+AA
Sbjct: 642 VLTEV-PNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 700
Query: 1105 IQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRA 1164
+ +V + L++ R V KL +PL LA + H +V +LV AG S E+
Sbjct: 701 LNNHREVAQILIREGRCDVNVRNRKL--QSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEE 758
Query: 1165 GLTAVHLAAE 1174
G TA+H+A +
Sbjct: 759 GDTALHVALQ 768
Score = 101 bits (242), Expect = 3e-20
Identities = 71/249 (28%), Positives = 123/249 (49%), Gaps = 8/249 (3%)
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
+GR+AL +AA G +++ LL +A ++ G TALH AA+ + L+
Sbjct: 522 QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLL-SAGC 580
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA--AQNNYSEVV 1078
D + + T LH+A G +EV + L E G +++ D P+H+A A S +V
Sbjct: 581 RADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIV 640
Query: 1079 QLFLQQHPNL-VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
++ L + PN+ V AT G T H A+++G + +++ R ++ A+ K + T L
Sbjct: 641 EV-LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQ-LVDAK-KEDGFTALH 697
Query: 1138 LAAEGGHADVVRVLVRAG-ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
LAA H +V ++L+R G NR + +HLA + H ++ ++ + +
Sbjct: 698 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 757
Query: 1197 LGLTPLHIA 1205
G T LH+A
Sbjct: 758 EGDTALHVA 766
Score = 96.7 bits (230), Expect = 8e-19
Identities = 72/245 (29%), Positives = 118/245 (48%), Gaps = 17/245 (6%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
T LQ+AA G +++R+L++A A + G TA+H AA V+ S +
Sbjct: 525 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 584
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLH--LA 1251
T LH+A G E VR L E V+L A S TPLH ++
Sbjct: 585 INSTQSTALHVAVQRGFLEVVRALC---------ERGCDVNLPD---AHSD-TPLHSAIS 631
Query: 1252 AYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDR 1311
A G +V +L + A+N G+ LH A GH V +L+R+ +L+ +
Sbjct: 632 AGTGASGIVEVLTEVPNIDV-TATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE 690
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
G T LH+A+ + H ++ ++L+ +G ++N ++ +PLH A + H+ +V LL ++G
Sbjct: 691 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 750
Query: 1371 SPKSE 1375
S +E
Sbjct: 751 SVNAE 755
Score = 94.3 bits (224), Expect = 4e-18
Identities = 86/292 (29%), Positives = 128/292 (43%), Gaps = 20/292 (6%)
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNK 1129
A N + + L L++ P V T G T +AA G V++I L++ R GV ++
Sbjct: 499 ALGNAARALDL-LRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQA-RAGVDLPDDE 555
Query: 1130 LNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT 1189
N T L AA G + RVL+ AG N TA+H+A + G V+ +
Sbjct: 556 GN--TALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC 613
Query: 1190 LRISSKKLGLTPLHIAAYYGQ-AETVRELLSHVPGTVKSEAPTGVSLVPVLGAES-GLTP 1247
TPLH A G A + E+L+ VP + V S G T
Sbjct: 614 DVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN------------IDVTATNSQGFTL 661
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH A+ G+ VR +L A DA E+G+ LHLA H + +L+ ++
Sbjct: 662 LHHASLKGHALAVRKILARARQLVDA-KKEDGFTALHLAALNNHREVAQILIREGRCDVN 720
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
+R ++ LH+A H +V +L+ G +NA D+ G T LH A + L
Sbjct: 721 VRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL 772
Score = 84.2 bits (199), Expect = 4e-15
Identities = 78/250 (31%), Positives = 115/250 (46%), Gaps = 22/250 (8%)
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
A +D G V +A + LD++R ++ +K G T L +AAY GQ E +R
Sbjct: 483 AQKSDPEHPGRLVVEVALGNA-ARALDLLRRRPE-QVDTKNQGRTALQVAAYLGQVELIR 540
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS 1275
LL +A GV L + G T LH AA R+LL SAG +ADA
Sbjct: 541 LLL---------QARAGVDLPD----DEGNTALHYAALGNQPEATRVLL-SAGCRADAI- 585
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH--IASTHGHYQMVEVLL 1333
N LH+A G + +V L R ++ + D H T LH I++ G +VEVL
Sbjct: 586 NSTQSTALHVAVQRGFLEVVRALCERGCDV-NLPDAHSDTPLHSAISAGTGASGIVEVLT 644
Query: 1334 G-QGAEINATDKNGWTPLHCAAKAGH-LNVVKLLCESGASPKSETNLNCAPIWFAASENH 1391
++ AT+ G+T LH A+ GH L V K+L + ++ + AA NH
Sbjct: 645 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 704
Query: 1392 NDVLEYLLHK 1401
+V + L+ +
Sbjct: 705 REVAQILIRE 714
Score = 82.6 bits (195), Expect = 1e-14
Identities = 79/275 (28%), Positives = 130/275 (47%), Gaps = 32/275 (11%)
Query: 804 GETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVK 863
G T LQ+A +++R L++ + A +D D++G +ALHYA +
Sbjct: 523 GRTALQVAAYLGQVELIRLLLQ----------ARAGVDLPDDEGNTALHYAALGNQ---- 568
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALN 923
P A R ++ A S Q+ TA H G +V+ + DV N
Sbjct: 569 -PEATRVLLSAGCRADAINSTQS-----TALHVAVQRGFLEVVRALCER--GCDV----N 616
Query: 924 RQNSIGWTPL--LIACHRGHMQLVNTLLTNHARVDVF--DVEGRSALHLAAEHGY-LQVC 978
++ TPL I+ G +V +LT +DV + +G + LH A+ G+ L V
Sbjct: 617 LPDAHSDTPLHSAISAGTGASGIVE-VLTEVPNIDVTATNSQGFTLLHHASLKGHALAVR 675
Query: 979 DALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
L + +++K +G TALHLAA+N + + + LIR+ ++V K Q+PLHLA
Sbjct: 676 KILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQ 735
Query: 1039 SGQIEVCKLLLELGANIDATDELGQKPIHAAAQNN 1073
+ + LL++ G +++A DE G +H A Q +
Sbjct: 736 QAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRH 770
Score = 77.0 bits (181), Expect = 7e-13
Identities = 99/375 (26%), Positives = 162/375 (43%), Gaps = 27/375 (7%)
Query: 995 GRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
GR + +A N L L+R +D + +T L +AA GQ+E+ +LLL+ A
Sbjct: 492 GRLVVEVALGNAARALD--LLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAG 548
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
+D D+ G +H AA N E ++ L A +T H+A +G ++V+
Sbjct: 549 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCR-ADAINSTQSTALHVAVQRGFLEVVRA 607
Query: 1115 LMKFDRTGVISARNKLNDSTPLQ--LAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHL 1171
L +R ++ + +D TPL ++A G + +V VL T N G T +H
Sbjct: 608 LC--ERGCDVNLPDAHSD-TPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHH 664
Query: 1172 AAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAP 1230
A+ GH V ++ L + K+ G T LH+AA E + L+
Sbjct: 665 ASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIRE---------- 714
Query: 1231 TGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGG 1290
G V V + +PLHLA + +V LL++ AG + A +E G LH+A
Sbjct: 715 -GRCDVNVRNRKL-QSPLHLAVQQAHVGLVPLLVD-AGCSVN-AEDEEGDTALHVALQRH 770
Query: 1291 H-MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG-QGAEINATDKNGWT 1348
+ +V L R +GL ++ V L +GA+++ T+ G +
Sbjct: 771 QLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRS 830
Query: 1349 PLHCAAKAGHLNVVK 1363
PL AA+ L ++
Sbjct: 831 PLDLAAEGRVLKALQ 845
Score = 75.4 bits (177), Expect = 2e-12
Identities = 47/152 (30%), Positives = 71/152 (46%), Gaps = 4/152 (2%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G+ L +A G ++R LL A+ L G+TALH AA + R+L+ G
Sbjct: 522 QGRTALQVAAYLGQVELIRLLLQARAGVDLP--DDEGNTALHYAALGNQPEATRVLLSAG 579
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMH--LAAENGHAAI 179
DA N T LH+A G +V+ + + D TP+H ++A G + I
Sbjct: 580 CRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGI 639
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHA 211
+E+L + + G TL+H ASL GHA
Sbjct: 640 VEVLTEVPNIDVTATNSQGFTLLHHASLKGHA 671
Score = 69.7 bits (163), Expect = 1e-10
Identities = 47/168 (27%), Positives = 79/168 (47%), Gaps = 5/168 (2%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
DL G L A R LLSA + A TALH+A +R +++ R
Sbjct: 550 DLPDDEGNTALHYAALGNQPEATRVLLSAGC--RADAINSTQSTALHVAVQRGFLEVVRA 607
Query: 117 LVDYGAVVDATNGAGQTPLH--IAAAEGDEPLVKYFYGV-RANAAIADNEDRTPMHLAAE 173
L + G V+ + TPLH I+A G +V+ V + +++ T +H A+
Sbjct: 608 LCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASL 667
Query: 174 NGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
GHA + + + + + + +DG T +H+A+LN H + A +L ++G
Sbjct: 668 KGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREG 715
Score = 68.5 bits (160), Expect = 2e-10
Identities = 83/316 (26%), Positives = 133/316 (42%), Gaps = 36/316 (11%)
Query: 731 ETPLHIAARIPDGDKC-ALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
E P + + G+ AL LL+ G T + VAA G + + LLL+
Sbjct: 489 EHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQ---- 544
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGAS 849
+ V + D G T L A P+ R L+ + DA++ ++
Sbjct: 545 --ARAGVDLPD-DEGNTALHYAALGNQPEATRVLLS----------AGCRADAINSTQST 591
Query: 850 ALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN-DVMTE 908
ALH V + +VV+ L E G DV+L H+ +T H AG + E
Sbjct: 592 ALH---------VAVQRGFLEVVRALCERGCDVNLPDAHS-DTPLHSAISAGTGASGIVE 641
Query: 909 MIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR-VDVFDVEGRSALH 967
++ + DV+ NS G+T L A +GH V +L + VD +G +ALH
Sbjct: 642 VLTEVPNIDVTAT----NSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 697
Query: 968 LAAEHGYLQVCDALL-TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
LAA + + +V L+ + +N + R ++ LHLA + LV L+ D ++
Sbjct: 698 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLV-DAGCSVNAED 756
Query: 1027 LKKQTPLHLAAASGQI 1042
+ T LH+A Q+
Sbjct: 757 EEGDTALHVALQRHQL 772
Score = 54.4 bits (125), Expect = 4e-06
Identities = 41/130 (31%), Positives = 64/130 (49%), Gaps = 5/130 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGES-VDVTTNDNYTALHIAVESCKPAVVETLLGYG-A 720
G +H A+ GH + +L + VD D +TALH+A + V + L+ G
Sbjct: 658 GFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRC 717
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
DV++R ++ ++PLH+A + L L+ +G N E+G T +HVA + L L
Sbjct: 718 DVNVR-NRKLQSPLHLAVQQAHVGLVPL-LVDAGCSVNAEDEEGDTALHVALQRHQLLPL 775
Query: 781 VLLLEDGGDP 790
V GGDP
Sbjct: 776 V-ADGAGGDP 784
Score = 50.0 bits (114), Expect = 9e-05
Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 2/120 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L++ V GN + +LL + EQ+ T G TAL +AA V++ R+L+ A VD
Sbjct: 494 LVVEVALGNAARALDLLRRRP-EQVD-TKNQGRTALQVAAYLGQVELIRLLLQARAGVDL 551
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G T LH AA + A ++ T +H+A + G ++ L ++
Sbjct: 552 PDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCER 611
Score = 48.0 bits (109), Expect = 4e-04
Identities = 36/113 (31%), Positives = 57/113 (50%), Gaps = 4/113 (3%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV-VDATNGAGQ 132
G+ VR++L A+ + + A G TALHLAA ++A+IL+ G V+ N Q
Sbjct: 669 GHALAVRKIL-ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQ 727
Query: 133 TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+PLH+A + LV + D E T +H+A + H ++ L+AD
Sbjct: 728 SPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQR-H-QLLPLVAD 778
Score = 46.0 bits (104), Expect = 0.001
Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 6/169 (3%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH--LAARRRDVDMA 114
D + L +AV+ G +VR L + + DT LH ++A +
Sbjct: 583 DAINSTQSTALHVAVQRGFLEVVRAL--CERGCDVNLPDAHSDTPLHSAISAGTGASGIV 640
Query: 115 RILVDYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAA 172
+L + + V ATN G T LH A+ +G V+ A ED T +HLAA
Sbjct: 641 EVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 700
Query: 173 ENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
N H + ++L + + + R + + +H+A H +L G
Sbjct: 701 LNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 749
Score = 43.2 bits (97), Expect = 0.010
Identities = 34/117 (29%), Positives = 47/117 (40%), Gaps = 2/117 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA G V +I LLQ VD+ ++ TALH A +P LL G
Sbjct: 523 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 582
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
Q T LH+A + + L + G N TP+H A G A+
Sbjct: 583 DAINSTQ-STALHVAVQ-RGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 637
Score = 39.5 bits (88), Expect = 0.13
Identities = 28/109 (25%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVE--SCKPAVVETLLGYGADVHI 724
+H A + HVG++ L+ G SV+ + TALH+A++ P V + G + +
Sbjct: 730 LHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQL 789
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK 773
+ + + L +A + G A L GA + G +P+ +AA+
Sbjct: 790 L-SRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE 837
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/107 (24%), Positives = 45/107 (42%), Gaps = 1/107 (0%)
Query: 1298 LLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAG 1357
LL R E + T G+T L +A+ G +++ +LL A ++ D G T LH AA
Sbjct: 509 LLRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 567
Query: 1358 HLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
++L +G + + + A +V+ L + D
Sbjct: 568 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 614
Score = 37.9 bits (84), Expect = 0.39
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 1/76 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H AA LL G D + TALH+AV+ VV L G D
Sbjct: 555 EGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 614
Query: 722 VHIRGGKQRETPLHIA 737
V++ +TPLH A
Sbjct: 615 VNLPDA-HSDTPLHSA 629
>AB033081-1|BAA86569.2| 1232|Homo sapiens KIAA1255 protein protein.
Length = 1232
Score = 108 bits (260), Expect = 2e-22
Identities = 161/637 (25%), Positives = 254/637 (39%), Gaps = 64/637 (10%)
Query: 744 DKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTK-------- 795
+ AL L +GA N + G TP+H A + G LL+ G +P +T+
Sbjct: 534 EAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKE 593
Query: 796 ----VCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
+ D V +TPL MA PD+V ++E K ++ + D +L
Sbjct: 594 AASLTSLADSVHLQTPLHMAIAYNHPDVVSVILE----QKANALHATNNLQIIPD--FSL 647
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIA 911
+ T + + T + L+ +GA ++ T + +T H ++ ++
Sbjct: 648 KDSRDQTVLGLALWTGMHTIAAQLLGSGAAIN-DTMSDGQTLLHMAIQRQDSKSALFLLE 706
Query: 912 HISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAE 971
H AD+ N + G T L +A +V+ + T A + V D +G L LA
Sbjct: 707 H--QADI----NVRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALA 760
Query: 972 HGYLQVCDALLTN--KAFINSKARNG--RTALHLAAMNGYAHLVKFLIRDH--------- 1018
+ + L+ + A G +T LH A FLIR
Sbjct: 761 NNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQP 820
Query: 1019 --NAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSE 1076
N + QTPLHLAA+ G E + LLE GAN++A D G+ PIH A + +
Sbjct: 821 GANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGV 880
Query: 1077 VVQLFLQQHPNL-VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTP 1135
++QL L HP++ + + G T A + K E ++K + NK +
Sbjct: 881 IIQL-LVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNF-- 937
Query: 1136 LQLAAEGGHADVVRVL--VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
L +A + + V L V A + ++ + LT +HLA + G ++ +
Sbjct: 938 LHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNE 997
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAY 1253
K T LH+AA LL + GV V E+G LHLA
Sbjct: 998 LTKHRQTALHLAAQQDLPTICSVLLEN-----------GVDFAAV--DENGNNALHLAVM 1044
Query: 1254 NGNENVVRLLLNSAGVQADAASNENGYNPLH-LACFG--GHMSIVGLLLS-RSAELLHST 1309
+G N +R+LL V A+ A N G +PLH L +G +I L L L
Sbjct: 1045 HGRLNNIRVLLTECTVDAE-AFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKP 1103
Query: 1310 DRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
D G T L +A G+ + ++ GA + + G
Sbjct: 1104 DADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQG 1140
Score = 104 bits (249), Expect = 4e-21
Identities = 201/799 (25%), Positives = 324/799 (40%), Gaps = 108/799 (13%)
Query: 699 ALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDK-CALMLLKSGAGP 757
AL +A+ ++ TL+ + ADV + K + LH I GD A L+K+GA
Sbjct: 322 ALDLALSRRLESIATTLVSHKADVDMVD-KSGWSLLHKG--IQRGDLFAATFLIKNGAFV 378
Query: 758 NKATEDGM-TPVHVAAKFGN----------LATLV-LLLEDGGDPLRKTKVCIYDVVTGE 805
N AT TP+H+ A + + +A + LL+ G +P + G
Sbjct: 379 NAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDS-------KGR 431
Query: 806 TPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACK---VTKEEV 862
TPL ++ + + L++ ++ D +G++AL A + V+ ++
Sbjct: 432 TPLHVSIMAGNEYVFSQLLQ---------CKQLDLELKDHEGSTALWLAVQHITVSSDQS 482
Query: 863 KIPTADRQVVK--CLIENGADVSLQTRHNH----ETAFHYCAIAGNNDVMTEMIAHISTA 916
P D VV EN L R +H +TA C + E A + A
Sbjct: 483 VNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAA-LFLA 541
Query: 917 DVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQ 976
+N +N G TPL AC G L LL A ++ + AL L E
Sbjct: 542 TNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNL---QTEEALPLPKEA---- 594
Query: 977 VCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH-NAM--------IDVLTL 1027
A LT+ A + + +T LH+A + +V ++ NA+ I +L
Sbjct: 595 ---ASLTSLA----DSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSL 647
Query: 1028 KK---QTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
K QT L LA +G + LL GA I+ T GQ +H A Q S+ LFL +
Sbjct: 648 KDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSA-LFLLE 706
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
H + T+DG T +A I+ + ++ + + R +S ++ + PL LA
Sbjct: 707 HQADINVRTQDGETALQLA-IRNQLPLVVDAI-CTRGADMSVPDE-KGNPPLWLALANNL 763
Query: 1145 ADVVRVLVRAG--ASCTDENRAGL--TAVHLAA-EHGHTNVLDVMRS---TNTLRI---- 1192
D+ LVR G A+C G T +H A E+ ++RS N+ R
Sbjct: 764 EDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGAN 823
Query: 1193 ----SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPL 1248
+ G TPLH+AA +G ETV+ LL +A G TP+
Sbjct: 824 GEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDA-------------EGRTPI 870
Query: 1249 HLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHS 1308
H+A + + +++LL++ + + + G P A + +L R +
Sbjct: 871 HVAISSQHGVIIQLLVSHPDIHLNVRDRQ-GLTPFACAMTFKNNKSAEAILKRESGAAEQ 929
Query: 1309 TDRHGKTGLHIASTHGHYQMVEVLLGQGAEINAT--DKNGWTPLHCAAKAGHLNVVKLLC 1366
D G+ LH+A + + V L+ A +N+ D + TPLH A +AG +V+ L
Sbjct: 930 VDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLL 989
Query: 1367 ESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHN 1426
+GA T + AA ++ + LL D ++ ++ +L V N
Sbjct: 990 LAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLN 1049
Query: 1427 NIPIEEFVLVSPAPVDTAA 1445
NI VL++ VD A
Sbjct: 1050 NIR----VLLTECTVDAEA 1064
Score = 102 bits (245), Expect = 1e-20
Identities = 131/495 (26%), Positives = 212/495 (42%), Gaps = 34/495 (6%)
Query: 682 LLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIP 741
LL G +++ T +D T LH+A++ LL + AD+++R + ET L +A R
Sbjct: 671 LLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVRT-QDGETALQLAIR-N 728
Query: 742 DGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV-LLLEDGGDPLRKTKVCIYD 800
+ GA + E G P+ +A NL + L+ G D C
Sbjct: 729 QLPLVVDAICTRGADMSVPDEKGNPPLWLALA-NNLEDIASTLVRHGCDA-----TCWGP 782
Query: 801 VVTG--ETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDE--DGASALHYACK 856
G +T L A LI D A + +E DG + LH A
Sbjct: 783 GPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAAS 842
Query: 857 VTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTA 916
EE V+CL+E GA+V+ Q T H AI+ + V+ +++ +S
Sbjct: 843 WGLEET---------VQCLLEFGANVNAQDAEGR-TPIHV-AISSQHGVIIQLL--VSHP 889
Query: 917 DVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHA-RVDVFDVEGRSALHLAAEHGYL 975
D+ LN ++ G TP A + + +L + + D +GR+ LH+A ++ +
Sbjct: 890 DIH--LNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDI 947
Query: 976 QVCDALLTNKAFINSKARNGR--TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPL 1033
+ L++ A +NS+ ++ T LHLA G +V+ L+ A ++ LT +QT L
Sbjct: 948 ESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLA-GAKVNELTKHRQTAL 1006
Query: 1034 HLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT 1093
HLAA +C +LLE G + A DE G +H A + +++ L + A
Sbjct: 1007 HLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFN 1066
Query: 1094 KDGNTCAHIAAIQG--SVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
G + HI G + I +L G + + ST L LA G+A++ R +
Sbjct: 1067 LRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAI 1126
Query: 1152 VRAGASCTDENRAGL 1166
VR+GA N G+
Sbjct: 1127 VRSGARLGVNNNQGV 1141
Score = 100 bits (240), Expect = 5e-20
Identities = 120/471 (25%), Positives = 187/471 (39%), Gaps = 45/471 (9%)
Query: 959 DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH 1018
D G AL LA + L+++KA ++ ++G + LH G FLI++
Sbjct: 316 DHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKN- 374
Query: 1019 NAMIDVLTLKKQ-TPLHLAAA-----------SGQIEVCKLLLELGANIDATDELGQKPI 1066
A ++ TL Q TPLHL A S ++ + LL+ GAN + D G+ P+
Sbjct: 375 GAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPL 434
Query: 1067 HAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISA 1126
H + V LQ + +G+T +A +V + + F+ V++
Sbjct: 435 HVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNG 494
Query: 1127 RNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRS 1186
+ +S +L G H D A +C + AG A + AA + +
Sbjct: 495 TSFDENSFAARLIQRGSHTDAPDT---ATGNCLLQRAAG--AGNEAAA--------LFLA 541
Query: 1187 TNTLRISSK-KLGLTPLHIAAYYGQAETVRELLSHV--PGTVKSEA----PTGVSLVPVL 1239
TN ++ + K G TPLH A +G A ELL P EA SL +
Sbjct: 542 TNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLA 601
Query: 1240 GAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASN-----------ENGYNPLHLACF 1288
+ TPLH+A + +VV ++L A +N L LA +
Sbjct: 602 DSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALW 661
Query: 1289 GGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWT 1348
G +I LL A + + T G+T LH+A + LL A+IN ++G T
Sbjct: 662 TGMHTIAAQLLGSGAAI-NDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVRTQDGET 720
Query: 1349 PLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
L A + VV +C GA P+W A + N D+ L+
Sbjct: 721 ALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLV 771
Score = 89.8 bits (213), Expect = 9e-17
Identities = 133/558 (23%), Positives = 232/558 (41%), Gaps = 56/558 (10%)
Query: 667 IHTAARYGHVGIINTLL-QKGESVDVTTN------------DNYTALHIAVESCKPAVVE 713
+H A Y H +++ +L QK ++ T N + T L +A+ + +
Sbjct: 610 LHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAA 669
Query: 714 TLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK 773
LLG GA ++ +T LH+A + D K AL LL+ A N T+DG T + +A +
Sbjct: 670 QLLGSGAAIN-DTMSDGQTLLHMAIQRQD-SKSALFLLEHQADINVRTQDGETALQLAIR 727
Query: 774 FGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKD---- 829
N LV+ R + + D G PL +A + + DI L+ D
Sbjct: 728 --NQLPLVV----DAICTRGADMSVPD-EKGNPPLWLALANNLEDIASTLVRHGCDATCW 780
Query: 830 --HKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
G + T A+DE+ AC + + + + RQ NG +
Sbjct: 781 GPGPGGCLQTLLHRAIDENNEPT---ACFLIRSGCDV-NSPRQPG----ANGE--GEEEA 830
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
+ +T H A G + + ++ + +N Q++ G TP+ +A H ++
Sbjct: 831 RDGQTPLHLAASWGLEETVQCLL------EFGANVNAQDAEGRTPIHVAISSQHGVIIQL 884
Query: 948 LLTN-HARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN-GRTALHLAAMN 1005
L+++ ++V D +G + A + +A+L ++ + N GR LH+A N
Sbjct: 885 LVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQN 944
Query: 1006 GYAHLVKFLIRDH-NAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQK 1064
V FLI H N V K TPLHLA +G + + LL GA ++ + Q
Sbjct: 945 SDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQT 1004
Query: 1065 PIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVI 1124
+H AAQ + + + L+ + A ++GN H+A + G + I L+ + T
Sbjct: 1005 ALHLAAQQDLPTICSVLLENGVDFA-AVDENGNNALHLAVMHGRLNNIRVLLT-ECTVDA 1062
Query: 1125 SARNKLNDSTPLQLAAEGGHADVVRVL-----VRAGASCTDENRAGLTAVHLAAEHGHTN 1179
A N L +PL + + G + + G + G T + LA G+ N
Sbjct: 1063 EAFN-LRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNAN 1121
Query: 1180 VL-DVMRSTNTLRISSKK 1196
+ ++RS L +++ +
Sbjct: 1122 LCRAIVRSGARLGVNNNQ 1139
Score = 89.0 bits (211), Expect = 2e-16
Identities = 100/395 (25%), Positives = 173/395 (43%), Gaps = 45/395 (11%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DG ++ A R +++ + +G + V L +A+ + + TL+ +G D
Sbjct: 717 DGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCD 776
Query: 722 VHIRG---GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATE------------DGMT 766
G G +T LH A + + A L++SG N + DG T
Sbjct: 777 ATCWGPGPGGCLQTLLHRAID-ENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQT 835
Query: 767 PVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
P+H+AA +G T+ LLE G + V D G TP+ +A S I++ L+
Sbjct: 836 PLHLAASWGLEETVQCLLEFGAN------VNAQDA-EGRTPIHVAISSQHGVIIQLLVSH 888
Query: 827 VKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQT 886
H ++ D G + +AC +T + K A ++K E+GA +
Sbjct: 889 PDIH---------LNVRDRQGLTP--FACAMTFKNNKSAEA---ILKR--ESGAAEQVDN 932
Query: 887 RHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVN 946
+ + F + A+ N+D+ + + A+V+ + Q++ TPL +A G +V
Sbjct: 933 KGRN---FLHVAVQ-NSDIESVLFLISVHANVNSRV--QDASKLTPLHLAVQAGSEIIVR 986
Query: 947 TLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNG 1006
LL A+V+ ++ALHLAA+ +C LL N + NG ALHLA M+G
Sbjct: 987 NLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHG 1046
Query: 1007 YAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
+ ++ L+ + + L+ Q+PLH+ G+
Sbjct: 1047 RLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGK 1081
Score = 87.4 bits (207), Expect = 5e-16
Identities = 112/474 (23%), Positives = 194/474 (40%), Gaps = 47/474 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DG +H A + LL+ ++V T D TAL +A+ + P VV+ + GAD
Sbjct: 684 DGQTLLHMAIQRQDSKSALFLLEHQADINVRTQDGETALQLAIRNQLPLVVDAICTRGAD 743
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKS------GAGPNKATEDGMTPVHVAAKFG 775
+ + K PL +A D + ++ G GP + T +H A
Sbjct: 744 MSVPDEK-GNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQ---TLLHRAIDEN 799
Query: 776 NLATLVLLLEDGGDPLRKTKVCI-----YDVVTGETPLQMACRSCMPDIVRHLIEFVKDH 830
N T L+ G D + + G+TPL +A + + V+ L+EF
Sbjct: 800 NEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEF---- 855
Query: 831 KGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNH 890
A ++A D +G + +H A ++ V+ L+ + D+ L R
Sbjct: 856 ------GANVNAQDAEGRTPIHVAI----------SSQHGVIIQLLVSHPDIHLNVRDRQ 899
Query: 891 ETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLT 950
CA+ N+ E I + + N+ G L +A ++ V L++
Sbjct: 900 GLTPFACAMTFKNNKSAEAILKRESGAAEQVDNK----GRNFLHVAVQNSDIESVLFLIS 955
Query: 951 NHARVD--VFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYA 1008
HA V+ V D + LHLA + G + LL A +N ++ +TALHLAA
Sbjct: 956 VHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLP 1015
Query: 1009 HLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL-ELGANIDATDELGQKPIH 1067
+ L+ ++ + LHLA G++ ++LL E + +A + GQ P+H
Sbjct: 1016 TICSVLL-ENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLH 1074
Query: 1068 AAAQ---NNYSEVVQLFLQQHPNLVM-ATTKDGNTCAHIAAIQGSVKVIEELMK 1117
Q N + + LFL+ P + DG+T +A ++G+ + +++
Sbjct: 1075 ILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVR 1128
Score = 83.8 bits (198), Expect = 6e-15
Identities = 167/693 (24%), Positives = 282/693 (40%), Gaps = 104/693 (15%)
Query: 838 AFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYC 897
A +D VD+ G S LH I D LI+NGA V+ T ET H
Sbjct: 343 ADVDMVDKSGWSLLHKG---------IQRGDLFAATFLIKNGAFVNAATLGAQETPLHLV 393
Query: 898 AIAGNN----DVMTEMIAHISTADVSRALN--RQNSIGWTPLLIACHRGHMQLVNTLLT- 950
A+ + DVM+EM A I+ A + N Q+S G TPL ++ G+ + + LL
Sbjct: 394 ALYSSKKHSADVMSEM-AQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQC 452
Query: 951 NHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHL 1010
+++ D EG +AL LA +H + V N F + NG + N +A
Sbjct: 453 KQLDLELKDHEGSTALWLAVQH--ITVSSDQSVNP-FEDVPVVNGTSFDE----NSFA-- 503
Query: 1011 VKFLIR-DHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA 1069
+ + R H D T L AA +G L GA+++ ++ G+ P+H A
Sbjct: 504 ARLIQRGSHTDAPDTAT--GNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTA 561
Query: 1070 AQNNYSEVVQLFLQQ--HPNLV----------------MATTKDGNTCAHIAAIQGSVKV 1111
++ + + LQQ +PNL +A + T H+A V
Sbjct: 562 CRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDV 621
Query: 1112 IEELMKFDRTGVISARNKLN-----------DSTPLQLAAEGGHADVVRVLVRAGASCTD 1160
+ +++ + + A N L D T L LA G + L+ +GA+ D
Sbjct: 622 VSVILE-QKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAIND 680
Query: 1161 ENRAGLTAVHLAAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
G T +H+A + + + L ++ + + ++ G T L +A + +
Sbjct: 681 TMSDGQTLLHMAIQRQDSKSALFLLEHQADINVRTQD-GETALQLA-----------IRN 728
Query: 1220 HVPGTVKSEAPTGVSL-VPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNEN 1278
+P V + G + VP E G PL LA N E++ L+ G A
Sbjct: 729 QLPLVVDAICTRGADMSVP---DEKGNPPLWLALANNLEDIASTLVRH-GCDATCWGPGP 784
Query: 1279 G---YNPLHLACFGGHMSIVGLLLSRSAELLHSTD-----------RHGKTGLHIASTHG 1324
G LH A + L+ ++ R G+T LH+A++ G
Sbjct: 785 GGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWG 844
Query: 1325 HYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNL----NC 1380
+ V+ LL GA +NA D G TP+H A + H +++LL + P N+
Sbjct: 845 LEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLV---SHPDIHLNVRDRQGL 901
Query: 1381 APIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAP 1440
P A + +N E +L +E +D+K N + + +++I F++ A
Sbjct: 902 TPFACAMTFKNNKSAEAILKRESGAAEQVDNKG--RNFLHVAVQNSDIESVLFLISVHAN 959
Query: 1441 VDT----AAKLSNIYINLSTKEKERAKDLIAAG 1469
V++ A+KL+ +++ + + ++L+ AG
Sbjct: 960 VNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAG 992
Score = 63.3 bits (147), Expect = 9e-09
Identities = 57/203 (28%), Positives = 95/203 (46%), Gaps = 11/203 (5%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LAV+AG++ +VR LL A ++ T TALHLAA++ + +L++ G
Sbjct: 972 PLHLAVQAGSEIIVRNLLLA--GAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFA 1029
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADN-EDRTPMHLAAENGH---AAIIE 181
A + G LH+A G ++ A A N ++P+H+ + G AAI +
Sbjct: 1030 AVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFD 1089
Query: 182 LLADKFKASIFERTK-DGSTLMHIASLNGHADCAMMLFKKGVYLHMPN----KYFEKQTF 236
L + ++ DGST++ +A + G+A+ + + G L + N F Q
Sbjct: 1090 LFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVNIFNYQVA 1149
Query: 237 DEVLFVKIENGLIKGLKSDDGSY 259
+ L ++ + L K DGSY
Sbjct: 1150 TKQLLFRLLDMLSKEPPWCDGSY 1172
Score = 52.8 bits (121), Expect = 1e-05
Identities = 46/154 (29%), Positives = 65/154 (42%), Gaps = 14/154 (9%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAG--DTALHLAARRRDVDMARILV 118
++G PL LA+ + + L+ P G T LH A + A L+
Sbjct: 749 EKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLI 808
Query: 119 DYGAVVDA-----TNGAG-------QTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRT 166
G V++ NG G QTPLH+AA+ G E V+ AN D E RT
Sbjct: 809 RSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRT 868
Query: 167 PMHLAAENGHAAIIELLADKFKASIFERTKDGST 200
P+H+A + H II+LL + R + G T
Sbjct: 869 PIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLT 902
Score = 45.2 bits (102), Expect = 0.003
Identities = 45/172 (26%), Positives = 76/172 (44%), Gaps = 7/172 (4%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R + L LA+ G ++ +LL + A + T G T LH+A +R+D A L+++
Sbjct: 651 RDQTVLGLALWTGMHTIAAQLLGSGAA--INDTMSDGQTLLHMAIQRQDSKSALFLLEHQ 708
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVR-ANAAIADNEDRTPMHLAAENGHAAII 180
A ++ G+T L + A PLV R A+ ++ D + P+ LA N I
Sbjct: 709 ADINVRTQDGETALQL-AIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIA 767
Query: 181 E-LLADKFKASIFERTKDG--STLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L+ A+ + G TL+H A + A L + G ++ P +
Sbjct: 768 STLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQ 819
Score = 44.4 bits (100), Expect = 0.004
Identities = 39/155 (25%), Positives = 71/155 (45%), Gaps = 14/155 (9%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G + L LA+ +S+ L+S + + +G + LH +R D+ A L+ GA
Sbjct: 319 GDLALDLALSRRLESIATTLVSHKA--DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGA 376
Query: 123 VVDA-TNGAGQTPLHIAAAEGDE-----------PLVKYFYGVRANAAIADNEDRTPMHL 170
V+A T GA +TPLH+ A + + + AN + D++ RTP+H+
Sbjct: 377 FVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHV 436
Query: 171 AAENGHAAIIELLADKFKASIFERTKDGSTLMHIA 205
+ G+ + L + + + +GST + +A
Sbjct: 437 SIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLA 471
Score = 42.7 bits (96), Expect = 0.014
Identities = 33/118 (27%), Positives = 51/118 (43%), Gaps = 10/118 (8%)
Query: 678 IINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIA 737
I TL+ VD+ ++ LH ++ L+ GA V+ +ETPLH+
Sbjct: 334 IATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLV 393
Query: 738 AR----------IPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
A + + + A LL++GA PN G TP+HV+ GN LL+
Sbjct: 394 ALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ 451
Score = 39.9 bits (89), Expect = 0.096
Identities = 27/99 (27%), Positives = 46/99 (46%), Gaps = 4/99 (4%)
Query: 1282 PLHLACFGGHMSIVGL-LLSRSAEL---LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGA 1337
PLH A +V L L+ ++L L+ D +G L +A + + L+ A
Sbjct: 284 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 343
Query: 1338 EINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSET 1376
+++ DK+GW+ LH + G L L ++GA + T
Sbjct: 344 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAAT 382
Score = 39.1 bits (87), Expect = 0.17
Identities = 37/156 (23%), Positives = 60/156 (38%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V +G+ L +AV+ + V L+S + + T LHLA + + R L+
Sbjct: 930 VDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLL 989
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
GA V+ QT LH+AA + + + A D +HLA +G
Sbjct: 990 LAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLN 1049
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCA 214
I +L + G + +HI G + A
Sbjct: 1050 NIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAA 1085
Score = 34.3 bits (75), Expect = 4.8
Identities = 30/102 (29%), Positives = 46/102 (45%), Gaps = 16/102 (15%)
Query: 132 QTPLHIAAAEGDEPLVKYFYGVRANA-------------AIADNEDRTPMHLAAENG-HA 177
QTPLH+A A +V +ANA ++ D+ D+T + LA G H
Sbjct: 607 QTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHT 666
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
+LL A+I + DG TL+H+A + A+ L +
Sbjct: 667 IAAQLLGS--GAAINDTMSDGQTLLHMAIQRQDSKSALFLLE 706
>AK124559-1|BAC85884.1| 1005|Homo sapiens protein ( Homo sapiens cDNA
FLJ42568 fis, clone BRACE3007625, moderately similar to
Rattus norvegicus espin (Espn). ).
Length = 1005
Score = 108 bits (259), Expect = 2e-22
Identities = 98/344 (28%), Positives = 154/344 (44%), Gaps = 22/344 (6%)
Query: 1027 LKKQTPLHLAAASGQIEVCKLLLELGA-NIDATDELGQKPIHAAAQNNYSEVVQLFLQQH 1085
++KQ L +AA G + + LLE GA TD LG +H A + + + V+ +Q+
Sbjct: 1 MEKQRAL-VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRA 59
Query: 1086 PNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNK-LNDSTPLQLAAEGGH 1144
+G T AH AA GS + EL R G +++ + +PL LAA GH
Sbjct: 60 QLPGNQRAHNGATPAHDAAATGS---LAELCWLVREGGCGLQDQDASGVSPLHLAARFGH 116
Query: 1145 ADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK-KLGLTPLH 1203
+V L+ G S T E R G +H AA G L ++ + + ++ + + G +PL+
Sbjct: 117 PVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLY 176
Query: 1204 IAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLL 1263
+A G + L+ V L A G++ LH AA G+ ++V L
Sbjct: 177 LACQEGHLHLAQFLVKDCGADVH------------LRALDGMSALHAAAARGHYSLVVWL 224
Query: 1264 LNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTH 1323
+ + A NE G LH A GGH I+ LL +L D G T LH A+ +
Sbjct: 225 VTFTDIGLTARDNE-GATALHFAARGGHTPILDRLLLMGTPILR--DSWGGTPLHDAAEN 281
Query: 1324 GHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
G + + L+ + + D++G+T A GH + + L E
Sbjct: 282 GQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLRE 325
Score = 104 bits (249), Expect = 4e-21
Identities = 98/334 (29%), Positives = 146/334 (43%), Gaps = 21/334 (6%)
Query: 934 LIACHRGHMQLVNTLLTNHAR-VDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI--NS 990
L+A G + + LL A + D G +H A G+L C L +A + N
Sbjct: 7 LVAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLD-CVKFLVQRAQLPGNQ 65
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
+A NG T H AA G + +L+R+ + +PLHLAA G + + LL
Sbjct: 66 RAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLH 125
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
G + G +P+H AA + ++L H + V T+ G + ++A +G +
Sbjct: 126 EGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLH 185
Query: 1111 VIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR-AGASCTDENRAGLTAV 1169
+ + L+K D + R L+ + L AA GH +V LV T + G TA+
Sbjct: 186 LAQFLVK-DCGADVHLR-ALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATAL 243
Query: 1170 HLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEA 1229
H AA GHT +LD + T I G TPLH AA GQ E + L+SH
Sbjct: 244 HFAARGGHTPILDRLLLMGT-PILRDSWGGTPLHDAAENGQMECCQTLVSH--------- 293
Query: 1230 PTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLL 1263
+ P L E G T LA Y+G+ + + L
Sbjct: 294 ----HVDPSLRDEDGYTAADLAEYHGHRDCAQYL 323
Score = 92.7 bits (220), Expect = 1e-17
Identities = 74/269 (27%), Positives = 117/269 (43%), Gaps = 15/269 (5%)
Query: 1131 NDSTPLQ-LAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT 1189
N +TP AA G A++ ++ G D++ +G++ +HLAA GH +++ +
Sbjct: 69 NGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGH 128
Query: 1190 LRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLH 1249
+ G PLH AA G T +LL+ G+ + SG +PL+
Sbjct: 129 SATLETREGARPLHHAAVSGDL-TCLKLLTAAHGSSVNRR-----------TRSGASPLY 176
Query: 1250 LAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHST 1309
LA G+ ++ + L+ G + + G + LH A GH S+V L++ + L +
Sbjct: 177 LACQEGHLHLAQFLVKDCGADVHLRALD-GMSALHAAAARGHYSLVVWLVTFTDIGLTAR 235
Query: 1310 DRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESG 1369
D G T LH A+ GH +++ LL G I D G TPLH AA+ G + + L
Sbjct: 236 DNEGATALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTPLHDAAENGQMECCQTLVSHH 294
Query: 1370 ASPKSETNLNCAPIWFAASENHNDVLEYL 1398
P A H D +YL
Sbjct: 295 VDPSLRDEDGYTAADLAEYHGHRDCAQYL 323
Score = 88.2 bits (209), Expect = 3e-16
Identities = 89/315 (28%), Positives = 131/315 (41%), Gaps = 21/315 (6%)
Query: 1100 AHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV-RAGASC 1158
A +AA G V +E L++ G + L + A GH D V+ LV RA
Sbjct: 6 ALVAAKDGDVATLERLLEAGALGP-GITDALGAGL-VHHATRAGHLDCVKFLVQRAQLPG 63
Query: 1159 TDENRAGLTAVHLAAEHGHTNVLD-VMRSTNTLRISSKKLGLTPLHIAAYYGQAETVREL 1217
G T H AA G L ++R G++PLH+AA +G V L
Sbjct: 64 NQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWL 123
Query: 1218 LSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNE 1277
L G S L G PLH AA +G+ ++LL + G + +
Sbjct: 124 LHE-----------GHSAT--LETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTR- 169
Query: 1278 NGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG-QG 1336
+G +PL+LAC GH+ + L+ +H G + LH A+ GHY +V L+
Sbjct: 170 SGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTD 229
Query: 1337 AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLE 1396
+ A D G T LH AA+ GH ++ L G +P + P+ AA + +
Sbjct: 230 IGLTARDNEGATALHFAARGGHTPILDRLLLMG-TPILRDSWGGTPLHDAAENGQMECCQ 288
Query: 1397 YLLHKEHDTQSLMDD 1411
L+ H SL D+
Sbjct: 289 TLV-SHHVDPSLRDE 302
Score = 88.2 bits (209), Expect = 3e-16
Identities = 82/294 (27%), Positives = 125/294 (42%), Gaps = 13/294 (4%)
Query: 895 HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM-QLVNTLLTNHA 953
H+ AG+ D + ++ RA N G TP A G + +L +
Sbjct: 41 HHATRAGHLDCVKFLVQRAQLPGNQRAHN-----GATPAHDAAATGSLAELCWLVREGGC 95
Query: 954 RVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKF 1013
+ D G S LHLAA G+ + + LL + R G LH AA++G +K
Sbjct: 96 GLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKL 155
Query: 1014 LIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL-ELGANIDATDELGQKPIHAAA-Q 1071
L H + ++ T +PL+LA G + + + L+ + GA++ G +HAAA +
Sbjct: 156 LTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAAR 215
Query: 1072 NNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLN 1131
+YS VV L L A +G T H AA G +++ L+ G R+
Sbjct: 216 GHYSLVVWLVTFTDIGLT-ARDNEGATALHFAARGGHTPILDRLLLM---GTPILRDSWG 271
Query: 1132 DSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMR 1185
TPL AAE G + + LV + + G TA LA HGH + +R
Sbjct: 272 -GTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLR 324
Score = 68.1 bits (159), Expect = 3e-10
Identities = 83/288 (28%), Positives = 123/288 (42%), Gaps = 36/288 (12%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
+H A R D ++ ++ N+ +G TP H AA G+LA L L+ +GG L+
Sbjct: 40 VHHATRAGHLDCVKFLVQRAQLPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQD 99
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHY 853
+G +PL +A R P +V L+ H+G S + +GA LH+
Sbjct: 100 QD------ASGVSPLHLAARFGHPVLVEWLL-----HEGHSATLE-----TREGARPLHH 143
Query: 854 ACKVTKEEVKIPTADRQVVKCL-IENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAH 912
A + D +K L +G+ V+ +TR Y A + + + +
Sbjct: 144 AA---------VSGDLTCLKLLTAAHGSSVNRRTRSGASPL--YLACQEGHLHLAQFLVK 192
Query: 913 ISTADVS-RALNRQNSIGWTPLLIACHRGHMQLVNTLLT-NHARVDVFDVEGRSALHLAA 970
ADV RAL+ G + L A RGH LV L+T + D EG +ALH AA
Sbjct: 193 DCGADVHLRALD-----GMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAA 247
Query: 971 EHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH 1018
G+ + D LL I + G T LH AA NG + L+ H
Sbjct: 248 RGGHTPILDRLLLMGTPILRDSWGG-TPLHDAAENGQMECCQTLVSHH 294
Score = 66.1 bits (154), Expect = 1e-09
Identities = 73/283 (25%), Positives = 127/283 (44%), Gaps = 31/283 (10%)
Query: 732 TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPL 791
TP H AA + ++ + G G G++P+H+AA+FG+ + LL +G
Sbjct: 72 TPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSAT 131
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
+T+ G PL A S D+ ++ + G SV+ GAS L
Sbjct: 132 LETR-------EGARPLHHAAVS--GDLT--CLKLLTAAHGSSVNRR-----TRSGASPL 175
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIA 911
+ AC +E + A V C GADV L+ + +A H A G+ ++ +
Sbjct: 176 YLAC----QEGHLHLAQFLVKDC----GADVHLRAL-DGMSALHAAAARGHYSLVVWL-- 224
Query: 912 HISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAE 971
++ D+ L +++ G T L A GH +++ LL + + D G + LH AAE
Sbjct: 225 -VTFTDI--GLTARDNEGATALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTPLHDAAE 280
Query: 972 HGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
+G ++ C L+++ + + +G TA LA +G+ ++L
Sbjct: 281 NGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYL 323
Score = 63.3 bits (147), Expect = 9e-09
Identities = 50/159 (31%), Positives = 74/159 (46%), Gaps = 5/159 (3%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV-D 119
+ G PL A +G+ + ++ LL+A + T +G + L+LA + + +A+ LV D
Sbjct: 135 REGARPLHHAAVSGDLTCLK-LLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKD 193
Query: 120 YGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIA-DNEDRTPMHLAAENGHAA 178
GA V G + LH AAA G LV + A DNE T +H AA GH
Sbjct: 194 CGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTP 253
Query: 179 IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
I++ L + R G T +H A+ NG +C L
Sbjct: 254 ILDRLL--LMGTPILRDSWGGTPLHDAAENGQMECCQTL 290
Score = 62.1 bits (144), Expect = 2e-08
Identities = 49/157 (31%), Positives = 72/157 (45%), Gaps = 6/157 (3%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAE-QLKATTPAGDTALHLAARRRDVDMARILVDYG 121
G PL LA + G+ + + L+ A+ L+A G +ALH AA R + LV +
Sbjct: 171 GASPLYLACQEGHLHLAQFLVKDCGADVHLRALD--GMSALHAAAARGHYSLVVWLVTFT 228
Query: 122 AV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
+ + A + G T LH AA G P++ + + D+ TP+H AAENG
Sbjct: 229 DIGLTARDNEGATALHFAARGGHTPILDRLL-LMGTPILRDSWGGTPLHDAAENGQMECC 287
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+ L R +DG T +A +GH DCA L
Sbjct: 288 QTLVSHHVDPSL-RDEDGYTAADLAEYHGHRDCAQYL 323
Score = 58.4 bits (135), Expect = 3e-07
Identities = 44/160 (27%), Positives = 77/160 (48%), Gaps = 5/160 (3%)
Query: 70 AVEAGNQSMVRELLS-AQTAEQLKATTPAGDTALHLAARRRDV-DMARILVDYGAVVDAT 127
A AG+ V+ L+ AQ +A G T H AA + ++ ++ + G +
Sbjct: 43 ATRAGHLDCVKFLVQRAQLPGNQRAHN--GATPAHDAAATGSLAELCWLVREGGCGLQDQ 100
Query: 128 NGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKF 187
+ +G +PLH+AA G LV++ +A + E P+H AA +G ++LL
Sbjct: 101 DASGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAH 160
Query: 188 KASIFERTKDGSTLMHIASLNGHADCAMMLFKK-GVYLHM 226
+S+ RT+ G++ +++A GH A L K G +H+
Sbjct: 161 GSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHL 200
Score = 55.6 bits (128), Expect = 2e-06
Identities = 41/150 (27%), Positives = 70/150 (46%), Gaps = 4/150 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVD-YG 121
G PL LA G+ +V LL + L+ T G LH AA D+ ++L +G
Sbjct: 104 GVSPLHLAARFGHPVLVEWLLHEGHSATLE--TREGARPLHHAAVSGDLTCLKLLTAAHG 161
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFY-GVRANAAIADNEDRTPMHLAAENGHAAII 180
+ V+ +G +PL++A EG L ++ A+ + + + +H AA GH +++
Sbjct: 162 SSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLV 221
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGH 210
L + R +G+T +H A+ GH
Sbjct: 222 VWLVTFTDIGLTARDNEGATALHFAARGGH 251
Score = 52.4 bits (120), Expect = 2e-05
Identities = 33/122 (27%), Positives = 51/122 (41%), Gaps = 1/122 (0%)
Query: 97 AGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRAN 156
+G + LHLAAR + L+ G G PLH AA GD +K +
Sbjct: 103 SGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGS 162
Query: 157 AAIADNED-RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAM 215
+ +P++LA + GH + + L A + R DG + +H A+ GH +
Sbjct: 163 SVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVV 222
Query: 216 ML 217
L
Sbjct: 223 WL 224
Score = 51.2 bits (117), Expect = 4e-05
Identities = 34/123 (27%), Positives = 60/123 (48%), Gaps = 2/123 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETL-LGYGAD 721
G +H AAR+GH ++ LL +G S + T + LH A S ++ L +G+
Sbjct: 104 GVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSS 163
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V+ R + +PL++A + ++ GA + DGM+ +H AA G+ + +V
Sbjct: 164 VN-RRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVV 222
Query: 782 LLL 784
L+
Sbjct: 223 WLV 225
Score = 43.6 bits (98), Expect = 0.008
Identities = 36/118 (30%), Positives = 55/118 (46%), Gaps = 8/118 (6%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDN--YTALHIAVESCKPAVVETLLGYG 719
DG ++H AA GH ++ L+ + + +T DN TALH A +++ LL G
Sbjct: 204 DGMSALHAAAARGHYSLVVWLVTFTD-IGLTARDNEGATALHFAARGGHTPILDRLLLMG 262
Query: 720 ADVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
+ +R TPLH AA +G +C L+ P+ EDG T +A G+
Sbjct: 263 TPI-LR-DSWGGTPLHDAAE--NGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGH 316
>DQ508815-1|ABF60230.1| 593|Homo sapiens SARP protein.
Length = 593
Score = 107 bits (258), Expect = 3e-22
Identities = 90/338 (26%), Positives = 152/338 (44%), Gaps = 18/338 (5%)
Query: 1033 LHLAAASGQIEVCKLLLELGANIDATDELGQ-KPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
+H A +G ++ ++ GA+I+ D L + P+H AA + E + L ++
Sbjct: 121 IHDAVRAGDVKQLSEIVVRGASINELDVLHKFTPLHWAAHSGSLECLHWLLWHGADITHV 180
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
TT+ G T +HIAAI+G ++ L+ G TPL LAA GH+ ++++
Sbjct: 181 TTR-GWTASHIAAIRGQDACVQALIM---NGANLTAQDDRGCTPLHLAATHGHSFTLQIM 236
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQA 1211
+R+G + ++ VH AA HG L ++ G P+H+AA G
Sbjct: 237 LRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHL 296
Query: 1212 ETVRELLSHVPGTVKSEAPTGVSLVPVLGA--ESGLTPLHLAAYNGNENVVRLLLNSAGV 1269
+ L+S + S VL A ++G L LA +N+++ + +
Sbjct: 297 HCFKFLVSRMS-----------SATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYE 345
Query: 1270 QADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMV 1329
D E P H+A F G + ++ L+ ++ +G T +H A+ GH + +
Sbjct: 346 GKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECL 405
Query: 1330 EVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
+ L+ GA+ N T+K G P A + HL VKLL E
Sbjct: 406 QWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEE 443
Score = 85.8 bits (203), Expect = 1e-15
Identities = 76/332 (22%), Positives = 146/332 (43%), Gaps = 11/332 (3%)
Query: 890 HETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLL 949
H + H AG+ ++E++ ++ + L++ +TPL A H G ++ ++ LL
Sbjct: 117 HFGSIHDAVRAGDVKQLSEIVVRGASINELDVLHK-----FTPLHWAAHSGSLECLHWLL 171
Query: 950 TNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAH 1009
+ A + G +A H+AA G AL+ N A + ++ G T LHLAA +G++
Sbjct: 172 WHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSF 231
Query: 1010 LVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA 1069
++ ++R V ++ P+H AA G++ +LL++ G +I+ D G P+H A
Sbjct: 232 TLQIMLRS-GVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLA 290
Query: 1070 AQNNYSEVVQLFLQQHPN---LVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISA 1126
A + + + + + ++ A +G +A +++ + + G
Sbjct: 291 AMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGK-DL 349
Query: 1127 RNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENR-AGLTAVHLAAEHGHTNVLDVMR 1185
++ + P +AA G +++ LV G +E G T +H AA GH L +
Sbjct: 350 EDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLI 409
Query: 1186 STNTLRISSKKLGLTPLHIAAYYGQAETVREL 1217
+ K G P +A + V+ L
Sbjct: 410 KMGADSNITNKAGERPSDVAKRFAHLAAVKLL 441
Score = 83.4 bits (197), Expect = 8e-15
Identities = 50/156 (32%), Positives = 77/156 (49%), Gaps = 3/156 (1%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
TPLH AA++G+ + LL + G+ H+A G + V L+ A L
Sbjct: 153 TPLHWAAHSGSLECLHWLLWHGADITHVTTR--GWTASHIAAIRGQDACVQALIMNGANL 210
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
DR G T LH+A+THGH ++++L G + + TDK W P+H AA G L ++LL
Sbjct: 211 TAQDDR-GCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLL 269
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
+ G S + P+ AA E H ++L+ +
Sbjct: 270 VKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSR 305
Score = 82.6 bits (195), Expect = 1e-14
Identities = 71/241 (29%), Positives = 113/241 (46%), Gaps = 17/241 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
T +AA G V+ L+ GA+ T ++ G T +HLAA HGH+ L +M +
Sbjct: 186 TASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSV 245
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAY 1253
+ K P+H AA++G+ ++ L+ G S+ V +G P+HLAA
Sbjct: 246 TDKREWRPVHYAAFHGRLGCLQLLVKW-----------GCSIEDV--DYNGNLPVHLAAM 292
Query: 1254 NGNENVVRLLLN--SAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDR 1311
G+ + + L++ S+ Q A N+NG N L LA +I+ + E D+
Sbjct: 293 EGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQ 352
Query: 1312 HGKTGL-HIASTHGHYQMVEVLLGQGA-EINATDKNGWTPLHCAAKAGHLNVVKLLCESG 1369
H+A+ G M++ L+ G IN NG TP+H AA GH+ ++ L + G
Sbjct: 353 ETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMG 412
Query: 1370 A 1370
A
Sbjct: 413 A 413
Score = 70.5 bits (165), Expect = 6e-11
Identities = 80/310 (25%), Positives = 126/310 (40%), Gaps = 20/310 (6%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L+ +GAD++ T TA H AI G + + +I + + L Q+ G TPL
Sbjct: 170 LLWHGADITHVTTRGW-TASHIAAIRGQDACVQALIMNGAN------LTAQDDRGCTPLH 222
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
+A GH + +L + V D +H AA HG L L+ I N
Sbjct: 223 LAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYN 282
Query: 995 GRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTL---KKQTPLHLAAASGQIEVCKLLLEL 1051
G +HLAAM G+ H KFL+ ++ VL + L LA + + + +
Sbjct: 283 GNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFI--Q 340
Query: 1052 GANIDATDELGQK----PIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQG 1107
GA + D Q+ P H AA +++ ++ + +G+T H AA QG
Sbjct: 341 GAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQG 400
Query: 1108 SVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGA-SCTDENRAGL 1166
++ ++ L+K I+ NK + P +A H V++L DEN
Sbjct: 401 HIECLQWLIKMGADSNIT--NKAGE-RPSDVAKRFAHLAAVKLLEELQKYDIDDENEIDE 457
Query: 1167 TAVHLAAEHG 1176
V HG
Sbjct: 458 NDVKYFIRHG 467
Score = 65.3 bits (152), Expect = 2e-09
Identities = 44/155 (28%), Positives = 73/155 (47%), Gaps = 3/155 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL A +G+ + LL + T G TA H+AA R + L+ GA +
Sbjct: 154 PLHWAAHSGSLECLHWLL--WHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLT 211
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
A + G TPLH+AA G ++ + ++ D + P+H AA +G ++LL
Sbjct: 212 AQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLV- 270
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
K+ SI + +G+ +H+A++ GH C L +
Sbjct: 271 KWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSR 305
Score = 64.9 bits (151), Expect = 3e-09
Identities = 44/127 (34%), Positives = 66/127 (51%), Gaps = 5/127 (3%)
Query: 666 SIHTAARYGHVGIINTLLQKGESV-DVTTNDNYTALHIAVESCKPAVVETLLGYGADV-H 723
SIH A R G V ++ ++ +G S+ ++ +T LH A S + LL +GAD+ H
Sbjct: 120 SIHDAVRAGDVKQLSEIVVRGASINELDVLHKFTPLHWAAHSGSLECLHWLLWHGADITH 179
Query: 724 IRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLL 783
+ + T HIAA I D C L+ +GA + G TP+H+AA G+ TL ++
Sbjct: 180 VT--TRGWTASHIAA-IRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIM 236
Query: 784 LEDGGDP 790
L G DP
Sbjct: 237 LRSGVDP 243
Score = 60.1 bits (139), Expect = 8e-08
Identities = 76/311 (24%), Positives = 134/311 (43%), Gaps = 32/311 (10%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA G + ++ LL G + T +TA HIA + A V+ L+ GA++ +
Sbjct: 155 LHWAAHSGSLECLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQD 214
Query: 727 GKQRETPLHIAARIPDGDKCAL-MLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
+ TPLH+AA G L ++L+SG P+ + PVH AA G L L LL++
Sbjct: 215 DRGC-TPLHLAAT--HGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVK 271
Query: 786 DGGDPLRKTKVCIYDV-VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVD 844
G I DV G P+ +A + H +F+ S +T + A +
Sbjct: 272 WG--------CSIEDVDYNGNLPVHLAAM----EGHLHCFKFLVSRM--SSATQVLKAFN 317
Query: 845 EDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNND 904
++G + L A + K+ + Q ++ G D L+ + H A G+
Sbjct: 318 DNGENVLDLAQRFFKQNI------LQFIQGAEYEGKD--LEDQETLAFPGHVAAFKGDLG 369
Query: 905 VMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRS 964
++ +++ D +N + G TP+ A +GH++ + L+ A ++ + G
Sbjct: 370 MLKKLV-----EDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGER 424
Query: 965 ALHLAAEHGYL 975
+A +L
Sbjct: 425 PSDVAKRFAHL 435
Score = 58.8 bits (136), Expect = 2e-07
Identities = 38/134 (28%), Positives = 61/134 (45%), Gaps = 2/134 (1%)
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
+ +H A G + + ++ R A + H T LH A+ G + + LL GA+I
Sbjct: 118 FGSIHDAVRAGDVKQLSEIVVRGASINELDVLHKFTPLHWAAHSGSLECLHWLLWHGADI 177
Query: 1340 NATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
GWT H AA G V+ L +GA+ ++ + C P+ AA+ H+ L+ +L
Sbjct: 178 THVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIML 237
Query: 1400 HKEHDTQSLMDDKR 1413
D + DKR
Sbjct: 238 RSGVDPS--VTDKR 249
Score = 54.8 bits (126), Expect = 3e-06
Identities = 36/123 (29%), Positives = 58/123 (47%), Gaps = 3/123 (2%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T LH AA ++ L+ +GA + G T HIAA G + V+ AN
Sbjct: 153 TPLHWAAHSGSLECLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTA 212
Query: 160 ADNEDRTPMHLAAENGHAAIIE-LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF 218
D+ TP+HLAA +GH+ ++ +L S+ ++ + +H A+ +G C +L
Sbjct: 213 QDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKRE--WRPVHYAAFHGRLGCLQLLV 270
Query: 219 KKG 221
K G
Sbjct: 271 KWG 273
Score = 53.6 bits (123), Expect = 7e-06
Identities = 38/142 (26%), Positives = 67/142 (47%), Gaps = 6/142 (4%)
Query: 98 GDTALHLAARRRDVDMARILVDYGA----VVDATNGAGQTPLHIAAAEGDEPLVKYFYGV 153
G+ +HLAA + + LV + V+ A N G+ L +A + ++++ G
Sbjct: 283 GNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGA 342
Query: 154 RANAAIADNEDRT--PMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHA 211
++++ P H+AA G +++ L + +I ER +GST MH A+ GH
Sbjct: 343 EYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHI 402
Query: 212 DCAMMLFKKGVYLHMPNKYFEK 233
+C L K G ++ NK E+
Sbjct: 403 ECLQWLIKMGADSNITNKAGER 424
Score = 43.2 bits (97), Expect = 0.010
Identities = 32/123 (26%), Positives = 56/123 (45%), Gaps = 2/123 (1%)
Query: 101 ALHLAARRRDVDMARILVDYGAVVDATNGAGQ-TPLHIAAAEGDEPLVKYFYGVRANAAI 159
++H A R DV +V GA ++ + + TPLH AA G + + A+
Sbjct: 120 SIHDAVRAGDVKQLSEIVVRGASINELDVLHKFTPLHWAAHSGSLECLHWLLWHGADITH 179
Query: 160 ADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
T H+AA G A ++ L A++ + G T +H+A+ +GH+ ++ +
Sbjct: 180 VTTRGWTASHIAAIRGQDACVQALIMN-GANLTAQDDRGCTPLHLAATHGHSFTLQIMLR 238
Query: 220 KGV 222
GV
Sbjct: 239 SGV 241
Score = 43.2 bits (97), Expect = 0.010
Identities = 25/90 (27%), Positives = 46/90 (51%), Gaps = 1/90 (1%)
Query: 103 HLAARRRDVDMARILVDYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIAD 161
H+AA + D+ M + LV+ G + ++ G TP+H AA +G +++ + A++ I +
Sbjct: 360 HVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITN 419
Query: 162 NEDRTPMHLAAENGHAAIIELLADKFKASI 191
P +A H A ++LL + K I
Sbjct: 420 KAGERPSDVAKRFAHLAAVKLLEELQKYDI 449
Score = 42.3 bits (95), Expect = 0.018
Identities = 31/115 (26%), Positives = 49/115 (42%), Gaps = 2/115 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G + H AA G + L+ G ++ + T LH+A ++ +L G D
Sbjct: 184 GWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDP 243
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
+ K+ P+H AA C +L+K G +G PVH+AA G+L
Sbjct: 244 SVT-DKREWRPVHYAA-FHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHL 296
Score = 39.5 bits (88), Expect = 0.13
Identities = 33/132 (25%), Positives = 50/132 (37%), Gaps = 2/132 (1%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V RG +A G + V+ L+ L A G T LHLAA +I++
Sbjct: 180 VTTRGWTASHIAAIRGQDACVQALI--MNGANLTAQDDRGCTPLHLAATHGHSFTLQIML 237
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
G T+ P+H AA G ++ + D P+HLAA GH
Sbjct: 238 RSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLH 297
Query: 179 IIELLADKFKAS 190
+ L + ++
Sbjct: 298 CFKFLVSRMSSA 309
>BC037542-1|AAH37542.1| 999|Homo sapiens MIB2 protein protein.
Length = 999
Score = 107 bits (258), Expect = 3e-22
Identities = 76/249 (30%), Positives = 126/249 (50%), Gaps = 6/249 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G T L +A + G ++L+ LL A VD+ D EG +ALH AA + LL+
Sbjct: 509 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 568
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH--LAAASGQIEVCK 1046
++ TALH+A G+ +V+ L + +++ TPLH ++A +G + +
Sbjct: 569 DAINSTQSTALHVAVQRGFLEVVRALC-ERGCDVNLPDAHSDTPLHSAISAGTGAGGIVE 627
Query: 1047 LLLEL-GANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAI 1105
+L E+ ++ AT+ G +H A+ ++ V+ L + LV A +DG T H+AA+
Sbjct: 628 VLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAAL 687
Query: 1106 QGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAG 1165
+V + L++ R V KL +PL LA + H +V +LV AG S E+ G
Sbjct: 688 NNHREVAQILIREGRCDVNVRNRKL--QSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEG 745
Query: 1166 LTAVHLAAE 1174
TA+H+A +
Sbjct: 746 DTALHVALQ 754
Score = 99 bits (238), Expect = 8e-20
Identities = 70/249 (28%), Positives = 122/249 (48%), Gaps = 8/249 (3%)
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
+GR+AL +AA G +++ LL +A ++ G TALH AA+ + L+
Sbjct: 508 QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLL-SAGC 566
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA--AQNNYSEVV 1078
D + + T LH+A G +EV + L E G +++ D P+H+A A +V
Sbjct: 567 RADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAGGIV 626
Query: 1079 QLFLQQHPNL-VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ 1137
++ L + PN+ V AT G T H A+++G + +++ R ++ A+ K + T L
Sbjct: 627 EV-LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQ-LVDAK-KEDGFTALH 683
Query: 1138 LAAEGGHADVVRVLVRAG-ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
LAA H +V ++L+R G NR + +HLA + H ++ ++ + +
Sbjct: 684 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 743
Query: 1197 LGLTPLHIA 1205
G T LH+A
Sbjct: 744 EGDTALHVA 752
Score = 95.9 bits (228), Expect = 1e-18
Identities = 72/245 (29%), Positives = 118/245 (48%), Gaps = 17/245 (6%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
T LQ+AA G +++R+L++A A + G TA+H AA V+ S +
Sbjct: 511 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 570
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLH--LA 1251
T LH+A G E VR L E V+L A S TPLH ++
Sbjct: 571 INSTQSTALHVAVQRGFLEVVRALC---------ERGCDVNLPD---AHSD-TPLHSAIS 617
Query: 1252 AYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDR 1311
A G +V +L + A+N G+ LH A GH V +L+R+ +L+ +
Sbjct: 618 AGTGAGGIVEVLTEVPNIDV-TATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE 676
Query: 1312 HGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
G T LH+A+ + H ++ ++L+ +G ++N ++ +PLH A + H+ +V LL ++G
Sbjct: 677 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 736
Query: 1371 SPKSE 1375
S +E
Sbjct: 737 SVNAE 741
Score = 93.1 bits (221), Expect = 1e-17
Identities = 83/280 (29%), Positives = 123/280 (43%), Gaps = 19/280 (6%)
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L++ P V T G T +AA G V++I L++ R GV ++ N T L AA
Sbjct: 496 LRRRPEQV-DTKNQGRTALQVAAYLGQVELIRLLLQA-RAGVDLPDDEGN--TALHYAAL 551
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTP 1201
G + RVL+ AG N TA+H+A + G V+ + TP
Sbjct: 552 GNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTP 611
Query: 1202 LHIAAYYGQ-AETVRELLSHVPGTVKSEAPTGVSLVPVLGAES-GLTPLHLAAYNGNENV 1259
LH A G A + E+L+ VP + V S G T LH A+ G+
Sbjct: 612 LHSAISAGTGAGGIVEVLTEVPN------------IDVTATNSQGFTLLHHASLKGHALA 659
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
VR +L A DA E+G+ LHLA H + +L+ ++ +R ++ LH+
Sbjct: 660 VRKILARARQLVDA-KKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHL 718
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
A H +V +L+ G +NA D+ G T LH A + L
Sbjct: 719 AVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL 758
Score = 81.0 bits (191), Expect = 4e-14
Identities = 70/215 (32%), Positives = 102/215 (47%), Gaps = 20/215 (9%)
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHL 1250
++ +K G T L +AAY GQ E +R LL +A GV L + G T LH
Sbjct: 502 QVDTKNQGRTALQVAAYLGQVELIRLLL---------QARAGVDLPD----DEGNTALHY 548
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AA R+LL SAG +ADA N LH+A G + +V L R ++ + D
Sbjct: 549 AALGNQPEATRVLL-SAGCRADAI-NSTQSTALHVAVQRGFLEVVRALCERGCDV-NLPD 605
Query: 1311 RHGKTGLH--IASTHGHYQMVEVLLG-QGAEINATDKNGWTPLHCAAKAGH-LNVVKLLC 1366
H T LH I++ G +VEVL ++ AT+ G+T LH A+ GH L V K+L
Sbjct: 606 AHSDTPLHSAISAGTGAGGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILA 665
Query: 1367 ESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
+ ++ + AA NH +V + L+ +
Sbjct: 666 RARQLVDAKKEDGFTALHLAALNNHREVAQILIRE 700
Score = 76.6 bits (180), Expect = 9e-13
Identities = 99/375 (26%), Positives = 161/375 (42%), Gaps = 27/375 (7%)
Query: 995 GRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
GR + +A N L L+R +D + +T L +AA GQ+E+ +LLL+ A
Sbjct: 478 GRLVVEVALGNAARALG--LLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAG 534
Query: 1055 IDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEE 1114
+D D+ G +H AA N E ++ L A +T H+A +G ++V+
Sbjct: 535 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCR-ADAINSTQSTALHVAVQRGFLEVVRA 593
Query: 1115 LMKFDRTGVISARNKLNDSTPLQ--LAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHL 1171
L +R ++ + +D TPL ++A G +V VL T N G T +H
Sbjct: 594 LC--ERGCDVNLPDAHSD-TPLHSAISAGTGAGGIVEVLTEVPNIDVTATNSQGFTLLHH 650
Query: 1172 AAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAP 1230
A+ GH V ++ L + K+ G T LH+AA E + L+
Sbjct: 651 ASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIRE---------- 700
Query: 1231 TGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGG 1290
G V V + +PLHLA + +V LL++ AG + A +E G LH+A
Sbjct: 701 -GRCDVNVRNRKL-QSPLHLAVQQAHVGLVPLLVD-AGCSVN-AEDEEGDTALHVALQRH 756
Query: 1291 H-MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG-QGAEINATDKNGWT 1348
+ +V L R +GL ++ V L +GA+++ T+ G +
Sbjct: 757 QLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRS 816
Query: 1349 PLHCAAKAGHLNVVK 1363
PL AA+ L ++
Sbjct: 817 PLDLAAEGRVLKALQ 831
Score = 75.8 bits (178), Expect = 2e-12
Identities = 81/309 (26%), Positives = 137/309 (44%), Gaps = 12/309 (3%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
++++ L++ A V L + TA HY A+ GN T ++ +S + A+N S
Sbjct: 523 ELIRLLLQARAGVDLPDDEGN-TALHYAAL-GNQPEATRVL--LSAGCRADAINSTQS-- 576
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGY-LQVCDALLTNKAFI 988
T L +A RG +++V L V++ D + LH A G +LT I
Sbjct: 577 -TALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAGGIVEVLTEVPNI 635
Query: 989 NSKARN--GRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCK 1046
+ A N G T LH A++ G+A V+ ++ ++D T LHLAA + EV +
Sbjct: 636 DVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQ 695
Query: 1047 LLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAI 1105
+L+ G +++ + Q P+H A Q + +V L + + V A ++G+T H+A
Sbjct: 696 ILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCS-VNAEDEEGDTALHVALQ 754
Query: 1106 QGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAG 1165
+ + + G + ++L S A A V L GA + N G
Sbjct: 755 RHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRG 814
Query: 1166 LTAVHLAAE 1174
+ + LAAE
Sbjct: 815 RSPLDLAAE 823
Score = 74.9 bits (176), Expect = 3e-12
Identities = 47/152 (30%), Positives = 70/152 (46%), Gaps = 4/152 (2%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
+G+ L +A G ++R LL A+ L G+TALH AA + R+L+ G
Sbjct: 508 QGRTALQVAAYLGQVELIRLLLQARAGVDLP--DDEGNTALHYAALGNQPEATRVLLSAG 565
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMH--LAAENGHAAI 179
DA N T LH+A G +V+ + + D TP+H ++A G I
Sbjct: 566 CRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAGGI 625
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHA 211
+E+L + + G TL+H ASL GHA
Sbjct: 626 VEVLTEVPNIDVTATNSQGFTLLHHASLKGHA 657
Score = 68.9 bits (161), Expect = 2e-10
Identities = 47/168 (27%), Positives = 79/168 (47%), Gaps = 5/168 (2%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
DL G L A R LLSA + A TALH+A +R +++ R
Sbjct: 536 DLPDDEGNTALHYAALGNQPEATRVLLSAGC--RADAINSTQSTALHVAVQRGFLEVVRA 593
Query: 117 LVDYGAVVDATNGAGQTPLH--IAAAEGDEPLVKYFYGV-RANAAIADNEDRTPMHLAAE 173
L + G V+ + TPLH I+A G +V+ V + +++ T +H A+
Sbjct: 594 LCERGCDVNLPDAHSDTPLHSAISAGTGAGGIVEVLTEVPNIDVTATNSQGFTLLHHASL 653
Query: 174 NGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
GHA + + + + + + +DG T +H+A+LN H + A +L ++G
Sbjct: 654 KGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREG 701
Score = 68.1 bits (159), Expect = 3e-10
Identities = 83/316 (26%), Positives = 133/316 (42%), Gaps = 36/316 (11%)
Query: 731 ETPLHIAARIPDGDKC-ALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGD 789
E P + + G+ AL LL+ G T + VAA G + + LLL+
Sbjct: 475 EHPGRLVVEVALGNAARALGLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQ---- 530
Query: 790 PLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGAS 849
+ V + D G T L A P+ R L+ + DA++ ++
Sbjct: 531 --ARAGVDLPD-DEGNTALHYAALGNQPEATRVLLS----------AGCRADAINSTQST 577
Query: 850 ALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN-DVMTE 908
ALH V + +VV+ L E G DV+L H+ +T H AG + E
Sbjct: 578 ALH---------VAVQRGFLEVVRALCERGCDVNLPDAHS-DTPLHSAISAGTGAGGIVE 627
Query: 909 MIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR-VDVFDVEGRSALH 967
++ + DV+ NS G+T L A +GH V +L + VD +G +ALH
Sbjct: 628 VLTEVPNIDVTAT----NSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 683
Query: 968 LAAEHGYLQVCDALL-TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
LAA + + +V L+ + +N + R ++ LHLA + LV L+ D ++
Sbjct: 684 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLV-DAGCSVNAED 742
Query: 1027 LKKQTPLHLAAASGQI 1042
+ T LH+A Q+
Sbjct: 743 EEGDTALHVALQRHQL 758
Score = 54.4 bits (125), Expect = 4e-06
Identities = 41/130 (31%), Positives = 64/130 (49%), Gaps = 5/130 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGES-VDVTTNDNYTALHIAVESCKPAVVETLLGYG-A 720
G +H A+ GH + +L + VD D +TALH+A + V + L+ G
Sbjct: 644 GFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRC 703
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
DV++R ++ ++PLH+A + L L+ +G N E+G T +HVA + L L
Sbjct: 704 DVNVR-NRKLQSPLHLAVQQAHVGLVPL-LVDAGCSVNAEDEEGDTALHVALQRHQLLPL 761
Query: 781 VLLLEDGGDP 790
V GGDP
Sbjct: 762 V-ADGAGGDP 770
Score = 48.4 bits (110), Expect = 3e-04
Identities = 33/120 (27%), Positives = 54/120 (45%), Gaps = 2/120 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L++ V GN + LL + EQ+ T G TAL +AA V++ R+L+ A VD
Sbjct: 480 LVVEVALGNAARALGLLRRRP-EQVD-TKNQGRTALQVAAYLGQVELIRLLLQARAGVDL 537
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G T LH AA + A ++ T +H+A + G ++ L ++
Sbjct: 538 PDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCER 597
Score = 48.0 bits (109), Expect = 4e-04
Identities = 36/113 (31%), Positives = 57/113 (50%), Gaps = 4/113 (3%)
Query: 74 GNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV-VDATNGAGQ 132
G+ VR++L A+ + + A G TALHLAA ++A+IL+ G V+ N Q
Sbjct: 655 GHALAVRKIL-ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQ 713
Query: 133 TPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+PLH+A + LV + D E T +H+A + H ++ L+AD
Sbjct: 714 SPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQR-H-QLLPLVAD 764
Score = 45.6 bits (103), Expect = 0.002
Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 6/169 (3%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH--LAARRRDVDMA 114
D + L +AV+ G +VR L + + DT LH ++A +
Sbjct: 569 DAINSTQSTALHVAVQRGFLEVVRAL--CERGCDVNLPDAHSDTPLHSAISAGTGAGGIV 626
Query: 115 RILVDYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TPMHLAA 172
+L + + V ATN G T LH A+ +G V+ A ED T +HLAA
Sbjct: 627 EVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 686
Query: 173 ENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
N H + ++L + + + R + + +H+A H +L G
Sbjct: 687 LNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 735
Score = 42.7 bits (96), Expect = 0.014
Identities = 33/113 (29%), Positives = 45/113 (39%), Gaps = 2/113 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA G V +I LLQ VD+ ++ TALH A +P LL G
Sbjct: 509 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 568
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Q T LH+A + + L + G N TP+H A G
Sbjct: 569 DAINSTQ-STALHVAVQ-RGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAG 619
Score = 40.3 bits (90), Expect = 0.072
Identities = 27/116 (23%), Positives = 48/116 (41%), Gaps = 2/116 (1%)
Query: 1289 GGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWT 1348
G +GLL R ++ T G+T L +A+ G +++ +LL A ++ D G T
Sbjct: 487 GNAARALGLLRRRPEQV--DTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNT 544
Query: 1349 PLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
LH AA ++L +G + + + A +V+ L + D
Sbjct: 545 ALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 600
Score = 39.5 bits (88), Expect = 0.13
Identities = 28/109 (25%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVE--SCKPAVVETLLGYGADVHI 724
+H A + HVG++ L+ G SV+ + TALH+A++ P V + G + +
Sbjct: 716 LHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQL 775
Query: 725 RGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK 773
+ + + L +A + G A L GA + G +P+ +AA+
Sbjct: 776 L-SRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE 823
Score = 37.9 bits (84), Expect = 0.39
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 1/76 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H AA LL G D + TALH+AV+ VV L G D
Sbjct: 541 EGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD 600
Query: 722 VHIRGGKQRETPLHIA 737
V++ +TPLH A
Sbjct: 601 VNLPDA-HSDTPLHSA 615
>AB033076-1|BAA86564.2| 1777|Homo sapiens KIAA1250 protein protein.
Length = 1777
Score = 107 bits (258), Expect = 3e-22
Identities = 110/408 (26%), Positives = 185/408 (45%), Gaps = 24/408 (5%)
Query: 945 VNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAM 1004
+ LL VD + G++ L +AAE G L++ L+ N A N + + TAL A+
Sbjct: 27 LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 86
Query: 1005 NGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQK 1064
G+ H+V+ L++ ++ + T L A G+ +V +LLL GAN T
Sbjct: 87 EGHVHIVEELLK-CGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVY 145
Query: 1065 PIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVI 1124
PI AA ++++V L LQ V + K G T AA +G ++ ++ L+ G
Sbjct: 146 PIIWAAGRGHADIVHLLLQNGAK-VNCSDKYGTTPLVWAARKGHLECVKHLLAM---GAD 201
Query: 1125 SARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ N T L +A +GG+ V+ +++ + ++ G TA+ +A++ GHT ++ +
Sbjct: 202 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 261
Query: 1185 RSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESG 1244
T + G T L A G E VR LL + + G +
Sbjct: 262 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYAD------------IDIRG-QDN 308
Query: 1245 LTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAE 1304
T L+ A GN +VR +L + + ++G PL A ++ +V LLL + A+
Sbjct: 309 KTALYWAVEKGNATMVRDIL-QCNPDTEICT-KDGETPLIKATKMRNIEVVELLLDKGAK 366
Query: 1305 LLHSTDRHGKTGLHIASTHGHYQMVEVLL---GQGAEINATDKNGWTP 1349
+ + D+ G T LHIA ++ E+LL G + +K G TP
Sbjct: 367 -VSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETP 413
Score = 107 bits (257), Expect = 4e-22
Identities = 96/366 (26%), Positives = 167/366 (45%), Gaps = 22/366 (6%)
Query: 1096 GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAG 1155
G T IAA QG++++++EL+K G L++ T L A++ GH +V L++ G
Sbjct: 44 GQTPLMIAAEQGNLEIVKELIK---NGANCNLEDLDNWTALISASKEGHVHIVEELLKCG 100
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVR 1215
+ + G TA+ A G T+V++++ S + + P+ AA G A+ V
Sbjct: 101 VNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVH 160
Query: 1216 ELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS 1275
LL + S+ + G TPL AA G+ V+ LL + G D
Sbjct: 161 LLLQNGAKVNCSD-------------KYGTTPLVWAARKGHLECVKHLL-AMGADVDQ-E 205
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQ 1335
N L +A GG+ V +L R+ + + TD+ G T L IAS GH ++V+ LL
Sbjct: 206 GANSMTALIVAVKGGYTQSVKEILKRNPNV-NLTDKDGNTALMIASKEGHTEIVQDLLDA 264
Query: 1336 GAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVL 1395
G +N D++G T L A + GH+ +V+ L + A N +++A + + ++
Sbjct: 265 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 324
Query: 1396 EYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLS 1455
+L DT+ D ++ + NI + E +L A V K + ++++
Sbjct: 325 RDILQCNPDTEICTKDGE---TPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 381
Query: 1456 TKEKER 1461
+ + R
Sbjct: 382 IRGRSR 387
Score = 107 bits (257), Expect = 4e-22
Identities = 103/379 (27%), Positives = 168/379 (44%), Gaps = 20/379 (5%)
Query: 1030 QTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
QTPL +AA G +E+ K L++ GAN + D + +A++ + +V+ L+ NL
Sbjct: 45 QTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLE 104
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVR 1149
G T A +G V+E L+ ++ L P+ AA GHAD+V
Sbjct: 105 HRDM-GGWTALMWACYKGRTDVVELLLSHGANPSVTG---LYSVYPIIWAAGRGHADIVH 160
Query: 1150 VLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYG 1209
+L++ GA ++ G T + AA GH + + + +T L +A G
Sbjct: 161 LLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGG 220
Query: 1210 QAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGV 1269
++V+E+L P V+L + G T L +A+ G+ +V+ LL+ AG
Sbjct: 221 YTQSVKEILKRNPN---------VNLTD----KDGNTALMIASKEGHTEIVQDLLD-AGT 266
Query: 1270 QADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMV 1329
+ + +G L A GGH+ IV LL + A++ + KT L+ A G+ MV
Sbjct: 267 YVNIP-DRSGDTVLIGAVRGGHVEIVRALLQKYADI-DIRGQDNKTALYWAVEKGNATMV 324
Query: 1330 EVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASE 1389
+L + K+G TPL A K ++ VV+LL + GA + P+ A
Sbjct: 325 RDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRG 384
Query: 1390 NHNDVLEYLLHKEHDTQSL 1408
+ E LL D + L
Sbjct: 385 RSRKLAELLLRNPKDGRLL 403
Score = 107 bits (256), Expect = 6e-22
Identities = 97/368 (26%), Positives = 170/368 (46%), Gaps = 13/368 (3%)
Query: 855 CKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHIS 914
C T + + ++VK LI+NGA+ +L+ N TA + G+ ++ E++
Sbjct: 43 CGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNW-TALISASKEGHVHIVEELLK--- 98
Query: 915 TADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGY 974
V+ L ++ GWT L+ AC++G +V LL++ A V + + AA G+
Sbjct: 99 -CGVN--LEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGH 155
Query: 975 LQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLH 1034
+ LL N A +N + G T L AA G+ VK L+ A +D T L
Sbjct: 156 ADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLA-MGADVDQEGANSMTALI 214
Query: 1035 LAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTK 1094
+A G + K +L+ N++ TD+ G + A++ ++E+VQ L V +
Sbjct: 215 VAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDA-GTYVNIPDR 273
Query: 1095 DGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRA 1154
G+T A G V+++ L++ + I R + ++ T L A E G+A +VR +++
Sbjct: 274 SGDTVLIGAVRGGHVEIVRALLQ--KYADIDIRGQ-DNKTALYWAVEKGNATMVRDILQC 330
Query: 1155 GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETV 1214
+ G T + A + + V++++ + K G TPLHI A G++ +
Sbjct: 331 NPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHI-AIRGRSRKL 389
Query: 1215 RELLSHVP 1222
ELL P
Sbjct: 390 AELLLRNP 397
Score = 105 bits (252), Expect = 2e-21
Identities = 107/387 (27%), Positives = 184/387 (47%), Gaps = 23/387 (5%)
Query: 980 ALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAAS 1039
ALL ++ + G+T L +AA G +VK LI++ A ++ L T L A+
Sbjct: 29 ALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKN-GANCNLEDLDNWTALISASKE 87
Query: 1040 GQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTC 1099
G + + + LL+ G N++ D G + A ++VV+L L N +
Sbjct: 88 GHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPI 147
Query: 1100 AHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
AA +G ++ L++ ++ +K +TPL AA GH + V+ L+ GA
Sbjct: 148 IW-AAGRGHADIVHLLLQ--NGAKVNCSDKYG-TTPLVWAARKGHLECVKHLLAMGADVD 203
Query: 1160 DENRAGLTAVHLAAEHGHT-NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
E +TA+ +A + G+T +V ++++ + ++ K G T L IA+ G E V++LL
Sbjct: 204 QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKD-GNTALMIASKEGHTEIVQDLL 262
Query: 1219 SHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNEN 1278
+A T V++ SG T L A G+ +VR LL D +N
Sbjct: 263 ---------DAGTYVNIPD----RSGDTVLIGAVRGGHVEIVRALLQKYA-DIDIRGQDN 308
Query: 1279 GYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAE 1338
L+ A G+ ++V +L + + T + G+T L A+ + ++VE+LL +GA+
Sbjct: 309 K-TALYWAVEKGNATMVRDILQCNPDTEICT-KDGETPLIKATKMRNIEVVELLLDKGAK 366
Query: 1339 INATDKNGWTPLHCAAKAGHLNVVKLL 1365
++A DK G TPLH A + + +LL
Sbjct: 367 VSAVDKKGDTPLHIAIRGRSRKLAELL 393
Score = 104 bits (250), Expect = 3e-21
Identities = 109/429 (25%), Positives = 200/429 (46%), Gaps = 41/429 (9%)
Query: 750 LLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQ 809
LL+ ++ E G TP+ +AA+ GNL + L+++G + C + + T L
Sbjct: 30 LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGAN-------CNLEDLDNWTALI 82
Query: 810 MACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADR 869
A + IV L++ + ++ D G +AL +AC + +V
Sbjct: 83 SASKEGHVHIVEELLKCGVN----------LEHRDMGGWTALMWACYKGRTDV------- 125
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
V+ L+ +GA+ S+ ++ + A G+ D++ H+ + ++ +N + G
Sbjct: 126 --VELLLSHGANPSVTGLYSVYPII-WAAGRGHADIV-----HLLLQNGAK-VNCSDKYG 176
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
TPL+ A +GH++ V LL A VD +AL +A + GY Q +L +N
Sbjct: 177 TTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVN 236
Query: 990 SKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL 1049
++G TAL +A+ G+ +V+ L+ D +++ T L A G +E+ + LL
Sbjct: 237 LTDKDGNTALMIASKEGHTEIVQDLL-DAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALL 295
Query: 1050 ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSV 1109
+ A+ID + + ++ A + + +V+ LQ +P+ + TKDG T A ++
Sbjct: 296 QKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEIC-TKDGETPLIKATKMRNI 354
Query: 1110 KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR---AGASCTDENRAGL 1166
+V+E L+ D+ +SA +K D TPL +A G + +L+R G N+AG
Sbjct: 355 EVVELLL--DKGAKVSAVDKKGD-TPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGE 411
Query: 1167 TAVHLAAEH 1175
T ++ H
Sbjct: 412 TPYNIDCSH 420
Score = 91.1 bits (216), Expect = 4e-17
Identities = 110/428 (25%), Positives = 190/428 (44%), Gaps = 43/428 (10%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G + AA G++ I+ L++ G + ++ DN+TAL A + +VE LL G ++
Sbjct: 44 GQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNL 103
Query: 723 HIR--GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
R GG T L A D L LL GA P+ + P+ AA G+ +
Sbjct: 104 EHRDMGG---WTALMWACYKGRTDVVEL-LLSHGANPSVTGLYSVYPIIWAAGRGHADIV 159
Query: 781 VLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFI 840
LLL++G KV D G TPL A R + V+HL+ D
Sbjct: 160 HLLLQNG------AKVNCSDKY-GTTPLVWAARKGHLECVKHLLAMGAD----------- 201
Query: 841 DAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIA 900
VD++GA+++ T V + Q VK +++ +V+L T + TA +
Sbjct: 202 --VDQEGANSM------TALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASKE 252
Query: 901 GNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDV 960
G+ +++ +++ D +N + G T L+ A GH+++V LL +A +D+
Sbjct: 253 GHTEIVQDLL------DAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQ 306
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
+ ++AL+ A E G + +L ++G T L A +V+ L+ D A
Sbjct: 307 DNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLL-DKGA 365
Query: 1021 MIDVLTLKKQTPLHLAAASGQIEVCKLLL---ELGANIDATDELGQKPIHAAAQNNYSEV 1077
+ + K TPLH+A ++ +LLL + G + ++ G+ P + + S +
Sbjct: 366 KVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSIL 425
Query: 1078 VQLFLQQH 1085
Q+F +H
Sbjct: 426 TQIFGARH 433
Score = 70.9 bits (166), Expect = 4e-11
Identities = 45/124 (36%), Positives = 59/124 (47%), Gaps = 1/124 (0%)
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQ 1335
NE G PL +A G++ IV L+ A + D T L AS GH +VE LL
Sbjct: 41 NECGQTPLMIAAEQGNLEIVKELIKNGANC-NLEDLDNWTALISASKEGHVHIVEELLKC 99
Query: 1336 GAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVL 1395
G + D GWT L A G +VV+LL GA+P + PI +AA H D++
Sbjct: 100 GVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIV 159
Query: 1396 EYLL 1399
LL
Sbjct: 160 HLLL 163
Score = 67.3 bits (157), Expect = 6e-10
Identities = 81/356 (22%), Positives = 159/356 (44%), Gaps = 35/356 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
D ++ +A++ GHV I+ LL+ G +++ +TAL A + VVE LL +GA+
Sbjct: 76 DNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGAN 135
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ G P+ AA D +LL++GA N + + G TP+ AA+ G+L +
Sbjct: 136 PSVT-GLYSVYPIIWAAGRGHAD-IVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVK 193
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LL G D + T L +A + V+ +++ ++
Sbjct: 194 HLLAMGAD-------VDQEGANSMTALIVAVKGGYTQSVKEILK----------RNPNVN 236
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
D+DG +AL A K ++V+ L++ G V++ R + +T G
Sbjct: 237 LTDKDGNTALMIASK---------EGHTEIVQDLLDAGTYVNIPDR-SGDTVLIGAVRGG 286
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ +++ ++ + D+ R + + ++ W A +G+ +V +L + ++ +
Sbjct: 287 HVEIVRALLQKYADIDI-RGQDNKTALYW-----AVEKGNATMVRDILQCNPDTEICTKD 340
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRD 1017
G + L A + ++V + LL A +++ + G T LH+A L + L+R+
Sbjct: 341 GETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRN 396
Score = 64.1 bits (149), Expect = 5e-09
Identities = 50/176 (28%), Positives = 82/176 (46%), Gaps = 6/176 (3%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
+L + G L++A + G+ +V++LL A T + +GDT L A R V++ R
Sbjct: 236 NLTDKDGNTALMIASKEGHTEIVQDLLDAGT--YVNIPDRSGDTVLIGAVRGGHVEIVRA 293
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+ A +D +T L+ A +G+ +V+ + I + TP+ A + +
Sbjct: 294 LLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRN 353
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF---KKGVYLHMPNK 229
++ELL DK A + K G T +HIA A +L K G L+ PNK
Sbjct: 354 IEVVELLLDK-GAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNK 408
Score = 58.8 bits (136), Expect = 2e-07
Identities = 51/169 (30%), Positives = 77/169 (45%), Gaps = 11/169 (6%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DG ++ A++ GH I+ LL G V++ T L AV +V LL AD
Sbjct: 241 DGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYAD 300
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALM-LLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
+ IR G+ +T L+ A + G+ + +L+ T+DG TP+ A K N+ +
Sbjct: 301 IDIR-GQDNKTALYWA--VEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVV 357
Query: 781 VLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKD 829
LLL+ G KV D G+TPL +A R + L+ KD
Sbjct: 358 ELLLDKG------AKVSAVD-KKGDTPLHIAIRGRSRKLAELLLRNPKD 399
Score = 57.2 bits (132), Expect = 6e-07
Identities = 37/126 (29%), Positives = 64/126 (50%), Gaps = 3/126 (2%)
Query: 105 AARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED 164
AA R D+ +L+ GA V+ ++ G TPL AA +G VK+ + A+
Sbjct: 150 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 209
Query: 165 RTPMHLAAENGHA-AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
T + +A + G+ ++ E+L K ++ KDG+T + IAS GH + L G Y
Sbjct: 210 MTALIVAVKGGYTQSVKEIL--KRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY 267
Query: 224 LHMPNK 229
+++P++
Sbjct: 268 VNIPDR 273
Score = 54.0 bits (124), Expect = 5e-06
Identities = 44/159 (27%), Positives = 70/159 (44%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ PL++A E GN +V+EL+ + TAL A++ V + L+ G
Sbjct: 44 GQTPLMIAAEQGNLEIVKELI--KNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGV 101
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
++ + G T L A +G +V+ AN ++ P+ AA GHA I+ L
Sbjct: 102 NLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHL 161
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L A + K G+T + A+ GH +C L G
Sbjct: 162 LLQN-GAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 199
Score = 50.4 bits (115), Expect = 7e-05
Identities = 33/98 (33%), Positives = 47/98 (47%), Gaps = 1/98 (1%)
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
VD N GQTPL IAA +G+ +VK AN + D ++ T + A++ GH I+E L
Sbjct: 37 VDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEEL 96
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
K ++ R G T + A G D +L G
Sbjct: 97 L-KCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHG 133
Score = 45.2 bits (102), Expect = 0.003
Identities = 39/149 (26%), Positives = 61/149 (40%), Gaps = 3/149 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL+ A G+ V+ LL+ + TAL +A + + ++
Sbjct: 176 GTTPLVWAARKGHLECVKHLLAMGADVDQEGANSM--TALIVAVKGGYTQSVKEILKRNP 233
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+ T+ G T L IA+ EG +V+ I D T + A GH I+
Sbjct: 234 NVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRA 293
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHA 211
L K+ A I R +D T ++ A G+A
Sbjct: 294 LLQKY-ADIDIRGQDNKTALYWAVEKGNA 321
Score = 43.6 bits (98), Expect = 0.008
Identities = 38/163 (23%), Positives = 66/163 (40%), Gaps = 3/163 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L+ A + G+ +V ELL L+ G TAL A + D+ +L+ +GA
Sbjct: 81 LISASKEGHVHIVEELLKCGV--NLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSV 138
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
T P+ AA G +V A +D TP+ AA GH ++ L
Sbjct: 139 TGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLL-A 197
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
A + + + T + +A G+ + K+ +++ +K
Sbjct: 198 MGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDK 240
Score = 40.3 bits (90), Expect = 0.072
Identities = 23/71 (32%), Positives = 41/71 (57%)
Query: 1329 VEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAAS 1388
++ LL + +++ ++ G TPL AA+ G+L +VK L ++GA+ E N + A+
Sbjct: 27 LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 86
Query: 1389 ENHNDVLEYLL 1399
E H ++E LL
Sbjct: 87 EGHVHIVEELL 97
Score = 36.7 bits (81), Expect = 0.89
Identities = 36/160 (22%), Positives = 64/160 (40%), Gaps = 3/160 (1%)
Query: 71 VEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGA 130
VE N ++ LL + + + G T L +AA + ++++ + L+ GA + +
Sbjct: 19 VEEENIPALKALL--EKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLD 76
Query: 131 GQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKAS 190
T L A+ EG +V+ N D T + A G ++ELL
Sbjct: 77 NWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANP 136
Query: 191 IFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
++ A GHAD +L + G ++ +KY
Sbjct: 137 SVTGLYSVYPIIWAAG-RGHADIVHLLLQNGAKVNCSDKY 175
>DQ822519-1|ABG46944.1| 835|Homo sapiens TNNI3 interacting kinase
protein.
Length = 835
Score = 107 bits (256), Expect = 6e-22
Identities = 100/339 (29%), Positives = 146/339 (43%), Gaps = 34/339 (10%)
Query: 1093 TKDGNTCAHIAAIQGSVKV-IEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
T++G + H+ I G K I LM G+ +R N T L LA +A+++ L
Sbjct: 64 TENGLSLLHLCCICGGKKSHIRTLML---KGLRPSRLTRNGFTALHLAVYKDNAELITSL 120
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQA 1211
+ +GA GLTA+H+A GH DV+ + TPLHIAAYYG
Sbjct: 121 LHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE 180
Query: 1212 ETVRELLS-----HVPGTVKSE-----APTGVSLVPVLGAESGL------------TPLH 1249
+ R LL +V G V + G + L E G PLH
Sbjct: 181 QVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLH 240
Query: 1250 LAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSA-ELLHS 1308
+ G+ ++V+ LL S N G PLHLAC+ G + ++ S E L
Sbjct: 241 FCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTK 300
Query: 1309 TDRHGKTGLHIASTHGH-YQMVEVLLGQGA-EINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
+ +T H A T+G +V+ LL Q IN ++G T LH A GH+ +V+ L
Sbjct: 301 ENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLL 360
Query: 1367 ESGASPKSETNL-NCAPIWFAASENHNDVLEYLLHKEHD 1404
++GA + NL C P + ++ L + K HD
Sbjct: 361 DNGA----DMNLVACDPSRSSGEKDEQTCLMWAYEKGHD 395
Score = 106 bits (255), Expect = 7e-22
Identities = 92/346 (26%), Positives = 156/346 (45%), Gaps = 28/346 (8%)
Query: 1033 LHLAA-ASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
LHL G+ + L+ G G +H A + +E++ L + +
Sbjct: 71 LHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGAD-IQQ 129
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
G T HIA I G ++ + L++ ++ ++ + TPL +AA GH V R+L
Sbjct: 130 VGYGGLTALHIATIAGHLEAADVLLQHGAN--VNIQDAVF-FTPLHIAAYYGHEQVTRLL 186
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDV-MRSTNTLRISSK-KLGLTPLHIAAYYG 1209
++ GA G +HLA+ G N+ + M + ++++ PLH + +G
Sbjct: 187 LKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFG 246
Query: 1210 QAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGV 1269
+ V+ LL +S+ +V + G TPLHLA YNG V + ++ +G
Sbjct: 247 HHDIVKYLL-------QSDLEVQPHVVNIYGD----TPLHLACYNGKFEVAKEIIQISGT 295
Query: 1270 QADAASNENGYNPLHLAC-FGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQM 1328
++ N H AC +G + +V LL ++ ++ R G TGLH A HGH ++
Sbjct: 296 ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL 355
Query: 1329 VEVLLGQGAEIN---------ATDKNGWTPLHCAAKAGHLNVVKLL 1365
V+ LL GA++N + +K+ T L A + GH +V LL
Sbjct: 356 VQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
Score = 100 bits (239), Expect = 6e-20
Identities = 59/167 (35%), Positives = 89/167 (53%), Gaps = 7/167 (4%)
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS-NENGYNPLHLACFGGHMSIVGLLLSR 1301
+G T LHLA Y N ++ LL+S AD G LH+A GH+ +LL
Sbjct: 100 NGFTALHLAVYKDNAELITSLLHSG---ADIQQVGYGGLTALHIATIAGHLEAADVLLQH 156
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNV 1361
A + + D T LHIA+ +GH Q+ +LL GA++N + + G PLH A+ G LN+
Sbjct: 157 GANV-NIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNI 215
Query: 1362 VKLLCESG--ASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQ 1406
KLL E G A ++ N + P+ F + H+D+++YLL + + Q
Sbjct: 216 AKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQ 262
Score = 90.2 bits (214), Expect = 7e-17
Identities = 96/368 (26%), Positives = 160/368 (43%), Gaps = 33/368 (8%)
Query: 833 ESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHET 892
E+ S ++ E+G S LH C I + ++ L+ G S TR N T
Sbjct: 53 EAFSKVNLNYRTENGLSLLHLCC--------ICGGKKSHIRTLMLKGLRPSRLTR-NGFT 103
Query: 893 AFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
A H N +++T ++ H S AD+ + G T L IA GH++ + LL +
Sbjct: 104 ALHLAVYKDNAELITSLL-H-SGADIQQV----GYGGLTALHIATIAGHLEAADVLLQHG 157
Query: 953 ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVK 1012
A V++ D + LH+AA +G+ QV LL A +N G LHLA+ G+ ++ K
Sbjct: 158 ANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAK 217
Query: 1013 FLIRD-HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID--ATDELGQKPIHAA 1069
L+ + A ++ + PLH + G ++ K LL+ + + G P+H A
Sbjct: 218 LLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLA 277
Query: 1070 AQNNYSEVVQLFLQ-QHPNLVMATTKDGNTCAHIAAIQG-SVKVIEELMKFDRTGVISAR 1127
N EV + +Q + T H A G S+ +++ L+ VI+
Sbjct: 278 CYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLD---QNVININ 334
Query: 1128 NKLNDS-TPLQLAAEGGHADVVRVLVRAGA-----SCTDENRAG----LTAVHLAAEHGH 1177
++ D T L A GH +V+ L+ GA +C +G T + A E GH
Sbjct: 335 HQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH 394
Query: 1178 TNVLDVMR 1185
++ +++
Sbjct: 395 DAIVTLLK 402
Score = 84.6 bits (200), Expect = 3e-15
Identities = 86/296 (29%), Positives = 137/296 (46%), Gaps = 27/296 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H A + +I +LL G + TALHIA + + LL +GA+
Sbjct: 100 NGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGAN 159
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V+I+ TPLHIAA ++ +LLK GA N + E G P+H+A+ G L
Sbjct: 160 VNIQDA-VFFTPLHIAAYY-GHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAK 217
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LL+E+G K V D PL R DIV++L++ D + +
Sbjct: 218 LLMEEGS----KADVNAQD-NEDHVPLHFCSRFGHHDIVKYLLQ--SDLEVQP------H 264
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
V+ G + LH AC K EV +++++ +G + + ETAFH G
Sbjct: 265 VVNIYGDTPLHLACYNGKFEVA-----KEIIQI---SGTESLTKENIFSETAFHSACTYG 316
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
+ +++ + +V +N Q G T L AC+ GH++LV LL N A +++
Sbjct: 317 KS---IDLVKFLLDQNVIN-INHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368
Score = 83.8 bits (198), Expect = 6e-15
Identities = 109/396 (27%), Positives = 173/396 (43%), Gaps = 42/396 (10%)
Query: 606 GNPTPVPTELLPIIWKP-ISKDSFYTLN-IDTAMELKSG-FFEDRMIFW-DTFFEK---- 657
GN PT+ WK +S+ T+ ++ +++K E R IF D F K
Sbjct: 2 GNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLN 61
Query: 658 YKHFDGARSIHTAARYG-HVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLL 716
Y+ +G +H G I TL+ KG T + +TALH+AV ++ +LL
Sbjct: 62 YRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL 121
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
GAD+ + G T LHIA I + A +LL+ GA N TP+H+AA +G+
Sbjct: 122 HSGADIQ-QVGYGGLTALHIAT-IAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 179
Query: 777 LATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVS 836
LLL+ G D +V G+ PL +A +I + L+E +G S
Sbjct: 180 EQVTRLLLKFGADVNVSGEV-------GDRPLHLASAKGFLNIAKLLME-----EG---S 224
Query: 837 TAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNH-ETAFH 895
A ++A D + LH+ + +VK L+++ +V + + +T H
Sbjct: 225 KADVNAQDNEDHVPLHFCSRF---------GHHDIVKYLLQSDLEVQPHVVNIYGDTPLH 275
Query: 896 YCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRG-HMQLVNTLL-TNHA 953
G +V E+I T +L ++N T AC G + LV LL N
Sbjct: 276 LACYNGKFEVAKEIIQISGT----ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVI 331
Query: 954 RVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
++ +G + LH A HG++++ LL N A +N
Sbjct: 332 NINHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN 367
Score = 83.0 bits (196), Expect = 1e-14
Identities = 56/189 (29%), Positives = 92/189 (48%), Gaps = 5/189 (2%)
Query: 1242 ESGLTPLHLAAY-NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLS 1300
E+GL+ LHL G ++ +R L+ G++ + NG+ LHLA + + ++ LL
Sbjct: 65 ENGLSLLHLCCICGGKKSHIRTLMLK-GLRPSRLTR-NGFTALHLAVYKDNAELITSLLH 122
Query: 1301 RSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
A++ G T LHIA+ GH + +VLL GA +N D +TPLH AA GH
Sbjct: 123 SGADI-QQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQ 181
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMV 1420
V +LL + GA + P+ A+++ ++ + L+ + D L
Sbjct: 182 VTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHF 241
Query: 1421 CSK-NHNNI 1428
CS+ H++I
Sbjct: 242 CSRFGHHDI 250
Score = 68.1 bits (159), Expect = 3e-10
Identities = 79/302 (26%), Positives = 141/302 (46%), Gaps = 35/302 (11%)
Query: 661 FDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
+ G ++H A GH+ + LLQ G +V++ +T LHIA V LL +GA
Sbjct: 132 YGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA 191
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSG--AGPNKATEDGMTPVHVAAKFGNLA 778
DV++ G+ + PLH+A+ A +L++ G A N + P+H ++FG+
Sbjct: 192 DVNV-SGEVGDRPLHLAS-AKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHD 249
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LL+ + ++ V IY G+TPL +AC + ++ + +I+ ES++
Sbjct: 250 IVKYLLQSDLE-VQPHVVNIY----GDTPLHLACYNGKFEVAKEIIQI---SGTESLTKE 301
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLI-ENGADVSLQTRHNHETAFHYC 897
I + +A H AC K +VK L+ +N +++ Q R H T H
Sbjct: 302 NIFS-----ETAFHSACTYGK--------SIDLVKFLLDQNVININHQGRDGH-TGLHSA 347
Query: 898 AIAGNNDVMTEMI-----AHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
G+ ++ ++ ++ D SR+ ++ T L+ A +GH +V TLL ++
Sbjct: 348 CYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDE--QTCLMWAYEKGHDAIV-TLLKHY 404
Query: 953 AR 954
R
Sbjct: 405 KR 406
Score = 67.3 bits (157), Expect = 6e-10
Identities = 56/195 (28%), Positives = 83/195 (42%), Gaps = 4/195 (2%)
Query: 28 QKDLQRLELSFIELNKERAKQKEWKKLIRDLVFQRGKVPL-LLAVEAGNQSMVRELLSAQ 86
+ DLQ E EL + + K+ + + G L L + G +S +R L+
Sbjct: 32 EDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKG 91
Query: 87 TAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPL 146
T G TALHLA + + ++ L+ GA + G T LHIA G
Sbjct: 92 LRPS--RLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEA 149
Query: 147 VKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIAS 206
AN I D TP+H+AA GH + LL KF A + + G +H+AS
Sbjct: 150 ADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLL-KFGADVNVSGEVGDRPLHLAS 208
Query: 207 LNGHADCAMMLFKKG 221
G + A +L ++G
Sbjct: 209 AKGFLNIAKLLMEEG 223
Score = 66.9 bits (156), Expect = 7e-10
Identities = 49/173 (28%), Positives = 79/173 (45%), Gaps = 5/173 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G L LAV N ++ LL + ++ G TALH+A ++ A +L+ +
Sbjct: 99 RNGFTALHLAVYKDNAELITSLL--HSGADIQQVGYGGLTALHIATIAGHLEAADVLLQH 156
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+ + TPLHIAA G E + + A+ ++ P+HLA+ G I
Sbjct: 157 GANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIA 216
Query: 181 ELLADK-FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG--VYLHMPNKY 230
+LL ++ KA + + + +H S GH D L + V H+ N Y
Sbjct: 217 KLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY 269
Score = 48.4 bits (110), Expect = 3e-04
Identities = 39/169 (23%), Positives = 67/169 (39%), Gaps = 5/169 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL LA G ++ + L+ + + A LH +R D+ + L+
Sbjct: 200 GDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDL 259
Query: 123 VVD--ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE--DRTPMHLAAENGHAA 178
V N G TPLH+A G + K + ++ T H A G +
Sbjct: 260 EVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSI 319
Query: 179 -IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHM 226
+++ L D+ +I + +DG T +H A +GH L G +++
Sbjct: 320 DLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368
Score = 44.8 bits (101), Expect = 0.003
Identities = 36/132 (27%), Positives = 56/132 (42%), Gaps = 11/132 (8%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARR-RDVDMARILVDYG 121
G PL LA G + +E++ E L +TA H A + +D+ + L+D
Sbjct: 270 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQN 329
Query: 122 AV-VDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIAD-------NEDRTPMHLA 171
+ ++ G T LH A G LV++ G N D +++T + A
Sbjct: 330 VININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWA 389
Query: 172 AENGHAAIIELL 183
E GH AI+ LL
Sbjct: 390 YEKGHDAIVTLL 401
Score = 33.5 bits (73), Expect = 8.3
Identities = 20/66 (30%), Positives = 34/66 (51%), Gaps = 1/66 (1%)
Query: 166 TPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
T +HLA +A +I L A I + G T +HIA++ GH + A +L + G ++
Sbjct: 103 TALHLAVYKDNAELITSLLHS-GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVN 161
Query: 226 MPNKYF 231
+ + F
Sbjct: 162 IQDAVF 167
>BX470253-1|CAI16293.1| 835|Homo sapiens TNNI3 interacting kinase
protein.
Length = 835
Score = 107 bits (256), Expect = 6e-22
Identities = 100/339 (29%), Positives = 146/339 (43%), Gaps = 34/339 (10%)
Query: 1093 TKDGNTCAHIAAIQGSVKV-IEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
T++G + H+ I G K I LM G+ +R N T L LA +A+++ L
Sbjct: 64 TENGLSLLHLCCICGGKKSHIRTLML---KGLRPSRLTRNGFTALHLAVYKDNAELITSL 120
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQA 1211
+ +GA GLTA+H+A GH DV+ + TPLHIAAYYG
Sbjct: 121 LHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE 180
Query: 1212 ETVRELLS-----HVPGTVKSE-----APTGVSLVPVLGAESGL------------TPLH 1249
+ R LL +V G V + G + L E G PLH
Sbjct: 181 QVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLH 240
Query: 1250 LAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSA-ELLHS 1308
+ G+ ++V+ LL S N G PLHLAC+ G + ++ S E L
Sbjct: 241 FCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTK 300
Query: 1309 TDRHGKTGLHIASTHGH-YQMVEVLLGQGA-EINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
+ +T H A T+G +V+ LL Q IN ++G T LH A GH+ +V+ L
Sbjct: 301 ENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLL 360
Query: 1367 ESGASPKSETNL-NCAPIWFAASENHNDVLEYLLHKEHD 1404
++GA + NL C P + ++ L + K HD
Sbjct: 361 DNGA----DMNLVACDPSRSSGEKDEQTCLMWAYEKGHD 395
Score = 106 bits (255), Expect = 7e-22
Identities = 92/346 (26%), Positives = 156/346 (45%), Gaps = 28/346 (8%)
Query: 1033 LHLAA-ASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
LHL G+ + L+ G G +H A + +E++ L + +
Sbjct: 71 LHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGAD-IQQ 129
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
G T HIA I G ++ + L++ ++ ++ + TPL +AA GH V R+L
Sbjct: 130 VGYGGLTALHIATIAGHLEAADVLLQHGAN--VNIQDAVF-FTPLHIAAYYGHEQVTRLL 186
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDV-MRSTNTLRISSK-KLGLTPLHIAAYYG 1209
++ GA G +HLA+ G N+ + M + ++++ PLH + +G
Sbjct: 187 LKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFG 246
Query: 1210 QAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGV 1269
+ V+ LL +S+ +V + G TPLHLA YNG V + ++ +G
Sbjct: 247 HHDIVKYLL-------QSDLEVQPHVVNIYGD----TPLHLACYNGKFEVAKEIIQISGT 295
Query: 1270 QADAASNENGYNPLHLAC-FGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQM 1328
++ N H AC +G + +V LL ++ ++ R G TGLH A HGH ++
Sbjct: 296 ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL 355
Query: 1329 VEVLLGQGAEIN---------ATDKNGWTPLHCAAKAGHLNVVKLL 1365
V+ LL GA++N + +K+ T L A + GH +V LL
Sbjct: 356 VQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
Score = 100 bits (239), Expect = 6e-20
Identities = 59/167 (35%), Positives = 89/167 (53%), Gaps = 7/167 (4%)
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS-NENGYNPLHLACFGGHMSIVGLLLSR 1301
+G T LHLA Y N ++ LL+S AD G LH+A GH+ +LL
Sbjct: 100 NGFTALHLAVYKDNAELITSLLHSG---ADIQQVGYGGLTALHIATIAGHLEAADVLLQH 156
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNV 1361
A + + D T LHIA+ +GH Q+ +LL GA++N + + G PLH A+ G LN+
Sbjct: 157 GANV-NIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNI 215
Query: 1362 VKLLCESG--ASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQ 1406
KLL E G A ++ N + P+ F + H+D+++YLL + + Q
Sbjct: 216 AKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQ 262
Score = 90.2 bits (214), Expect = 7e-17
Identities = 96/368 (26%), Positives = 160/368 (43%), Gaps = 33/368 (8%)
Query: 833 ESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHET 892
E+ S ++ E+G S LH C I + ++ L+ G S TR N T
Sbjct: 53 EAFSKVNLNYRTENGLSLLHLCC--------ICGGKKSHIRTLMLKGLRPSRLTR-NGFT 103
Query: 893 AFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
A H N +++T ++ H S AD+ + G T L IA GH++ + LL +
Sbjct: 104 ALHLAVYKDNAELITSLL-H-SGADIQQV----GYGGLTALHIATIAGHLEAADVLLQHG 157
Query: 953 ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVK 1012
A V++ D + LH+AA +G+ QV LL A +N G LHLA+ G+ ++ K
Sbjct: 158 ANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAK 217
Query: 1013 FLIRD-HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID--ATDELGQKPIHAA 1069
L+ + A ++ + PLH + G ++ K LL+ + + G P+H A
Sbjct: 218 LLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLA 277
Query: 1070 AQNNYSEVVQLFLQ-QHPNLVMATTKDGNTCAHIAAIQG-SVKVIEELMKFDRTGVISAR 1127
N EV + +Q + T H A G S+ +++ L+ VI+
Sbjct: 278 CYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLD---QNVININ 334
Query: 1128 NKLNDS-TPLQLAAEGGHADVVRVLVRAGA-----SCTDENRAG----LTAVHLAAEHGH 1177
++ D T L A GH +V+ L+ GA +C +G T + A E GH
Sbjct: 335 HQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH 394
Query: 1178 TNVLDVMR 1185
++ +++
Sbjct: 395 DAIVTLLK 402
Score = 84.6 bits (200), Expect = 3e-15
Identities = 86/296 (29%), Positives = 137/296 (46%), Gaps = 27/296 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H A + +I +LL G + TALHIA + + LL +GA+
Sbjct: 100 NGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGAN 159
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V+I+ TPLHIAA ++ +LLK GA N + E G P+H+A+ G L
Sbjct: 160 VNIQDA-VFFTPLHIAAYY-GHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAK 217
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LL+E+G K V D PL R DIV++L++ D + +
Sbjct: 218 LLMEEGS----KADVNAQD-NEDHVPLHFCSRFGHHDIVKYLLQ--SDLEVQP------H 264
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
V+ G + LH AC K EV +++++ +G + + ETAFH G
Sbjct: 265 VVNIYGDTPLHLACYNGKFEVA-----KEIIQI---SGTESLTKENIFSETAFHSACTYG 316
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
+ +++ + +V +N Q G T L AC+ GH++LV LL N A +++
Sbjct: 317 KS---IDLVKFLLDQNVIN-INHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368
Score = 83.8 bits (198), Expect = 6e-15
Identities = 109/396 (27%), Positives = 173/396 (43%), Gaps = 42/396 (10%)
Query: 606 GNPTPVPTELLPIIWKP-ISKDSFYTLN-IDTAMELKSG-FFEDRMIFW-DTFFEK---- 657
GN PT+ WK +S+ T+ ++ +++K E R IF D F K
Sbjct: 2 GNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLN 61
Query: 658 YKHFDGARSIHTAARYG-HVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLL 716
Y+ +G +H G I TL+ KG T + +TALH+AV ++ +LL
Sbjct: 62 YRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL 121
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
GAD+ + G T LHIA I + A +LL+ GA N TP+H+AA +G+
Sbjct: 122 HSGADIQ-QVGYGGLTALHIAT-IAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 179
Query: 777 LATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVS 836
LLL+ G D +V G+ PL +A +I + L+E +G S
Sbjct: 180 EQVTRLLLKFGADVNVSGEV-------GDRPLHLASAKGFLNIAKLLME-----EG---S 224
Query: 837 TAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNH-ETAFH 895
A ++A D + LH+ + +VK L+++ +V + + +T H
Sbjct: 225 KADVNAQDNEDHVPLHFCSRF---------GHHDIVKYLLQSDLEVQPHVVNIYGDTPLH 275
Query: 896 YCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRG-HMQLVNTLL-TNHA 953
G +V E+I T +L ++N T AC G + LV LL N
Sbjct: 276 LACYNGKFEVAKEIIQISGT----ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVI 331
Query: 954 RVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
++ +G + LH A HG++++ LL N A +N
Sbjct: 332 NINHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN 367
Score = 83.0 bits (196), Expect = 1e-14
Identities = 56/189 (29%), Positives = 92/189 (48%), Gaps = 5/189 (2%)
Query: 1242 ESGLTPLHLAAY-NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLS 1300
E+GL+ LHL G ++ +R L+ G++ + NG+ LHLA + + ++ LL
Sbjct: 65 ENGLSLLHLCCICGGKKSHIRTLMLK-GLRPSRLTR-NGFTALHLAVYKDNAELITSLLH 122
Query: 1301 RSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
A++ G T LHIA+ GH + +VLL GA +N D +TPLH AA GH
Sbjct: 123 SGADI-QQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQ 181
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMV 1420
V +LL + GA + P+ A+++ ++ + L+ + D L
Sbjct: 182 VTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHF 241
Query: 1421 CSK-NHNNI 1428
CS+ H++I
Sbjct: 242 CSRFGHHDI 250
Score = 68.1 bits (159), Expect = 3e-10
Identities = 79/302 (26%), Positives = 141/302 (46%), Gaps = 35/302 (11%)
Query: 661 FDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
+ G ++H A GH+ + LLQ G +V++ +T LHIA V LL +GA
Sbjct: 132 YGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA 191
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSG--AGPNKATEDGMTPVHVAAKFGNLA 778
DV++ G+ + PLH+A+ A +L++ G A N + P+H ++FG+
Sbjct: 192 DVNV-SGEVGDRPLHLAS-AKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHD 249
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LL+ + ++ V IY G+TPL +AC + ++ + +I+ ES++
Sbjct: 250 IVKYLLQSDLE-VQPHVVNIY----GDTPLHLACYNGKFEVAKEIIQI---SGTESLTKE 301
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLI-ENGADVSLQTRHNHETAFHYC 897
I + +A H AC K +VK L+ +N +++ Q R H T H
Sbjct: 302 NIFS-----ETAFHSACTYGK--------SIDLVKFLLDQNVININHQGRDGH-TGLHSA 347
Query: 898 AIAGNNDVMTEMI-----AHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
G+ ++ ++ ++ D SR+ ++ T L+ A +GH +V TLL ++
Sbjct: 348 CYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDE--QTCLMWAYEKGHDAIV-TLLKHY 404
Query: 953 AR 954
R
Sbjct: 405 KR 406
Score = 67.3 bits (157), Expect = 6e-10
Identities = 56/195 (28%), Positives = 83/195 (42%), Gaps = 4/195 (2%)
Query: 28 QKDLQRLELSFIELNKERAKQKEWKKLIRDLVFQRGKVPL-LLAVEAGNQSMVRELLSAQ 86
+ DLQ E EL + + K+ + + G L L + G +S +R L+
Sbjct: 32 EDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKG 91
Query: 87 TAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPL 146
T G TALHLA + + ++ L+ GA + G T LHIA G
Sbjct: 92 LRPS--RLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEA 149
Query: 147 VKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIAS 206
AN I D TP+H+AA GH + LL KF A + + G +H+AS
Sbjct: 150 ADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLL-KFGADVNVSGEVGDRPLHLAS 208
Query: 207 LNGHADCAMMLFKKG 221
G + A +L ++G
Sbjct: 209 AKGFLNIAKLLMEEG 223
Score = 66.9 bits (156), Expect = 7e-10
Identities = 49/173 (28%), Positives = 79/173 (45%), Gaps = 5/173 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G L LAV N ++ LL + ++ G TALH+A ++ A +L+ +
Sbjct: 99 RNGFTALHLAVYKDNAELITSLL--HSGADIQQVGYGGLTALHIATIAGHLEAADVLLQH 156
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+ + TPLHIAA G E + + A+ ++ P+HLA+ G I
Sbjct: 157 GANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIA 216
Query: 181 ELLADK-FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG--VYLHMPNKY 230
+LL ++ KA + + + +H S GH D L + V H+ N Y
Sbjct: 217 KLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY 269
Score = 48.4 bits (110), Expect = 3e-04
Identities = 39/169 (23%), Positives = 67/169 (39%), Gaps = 5/169 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL LA G ++ + L+ + + A LH +R D+ + L+
Sbjct: 200 GDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDL 259
Query: 123 VVD--ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE--DRTPMHLAAENGHAA 178
V N G TPLH+A G + K + ++ T H A G +
Sbjct: 260 EVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSI 319
Query: 179 -IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHM 226
+++ L D+ +I + +DG T +H A +GH L G +++
Sbjct: 320 DLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368
Score = 44.8 bits (101), Expect = 0.003
Identities = 36/132 (27%), Positives = 56/132 (42%), Gaps = 11/132 (8%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARR-RDVDMARILVDYG 121
G PL LA G + +E++ E L +TA H A + +D+ + L+D
Sbjct: 270 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQN 329
Query: 122 AV-VDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIAD-------NEDRTPMHLA 171
+ ++ G T LH A G LV++ G N D +++T + A
Sbjct: 330 VININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWA 389
Query: 172 AENGHAAIIELL 183
E GH AI+ LL
Sbjct: 390 YEKGHDAIVTLL 401
Score = 33.5 bits (73), Expect = 8.3
Identities = 20/66 (30%), Positives = 34/66 (51%), Gaps = 1/66 (1%)
Query: 166 TPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
T +HLA +A +I L A I + G T +HIA++ GH + A +L + G ++
Sbjct: 103 TALHLAVYKDNAELITSLLHS-GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVN 161
Query: 226 MPNKYF 231
+ + F
Sbjct: 162 IQDAVF 167
>BC117262-1|AAI17263.1| 835|Homo sapiens TNNI3 interacting kinase
protein.
Length = 835
Score = 107 bits (256), Expect = 6e-22
Identities = 100/339 (29%), Positives = 146/339 (43%), Gaps = 34/339 (10%)
Query: 1093 TKDGNTCAHIAAIQGSVKV-IEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
T++G + H+ I G K I LM G+ +R N T L LA +A+++ L
Sbjct: 64 TENGLSLLHLCCICGGKKSHIRTLML---KGLRPSRLTRNGFTALHLAVYKDNAELITSL 120
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQA 1211
+ +GA GLTA+H+A GH DV+ + TPLHIAAYYG
Sbjct: 121 LHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE 180
Query: 1212 ETVRELLS-----HVPGTVKSE-----APTGVSLVPVLGAESGL------------TPLH 1249
+ R LL +V G V + G + L E G PLH
Sbjct: 181 QVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLH 240
Query: 1250 LAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSA-ELLHS 1308
+ G+ ++V+ LL S N G PLHLAC+ G + ++ S E L
Sbjct: 241 FCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTK 300
Query: 1309 TDRHGKTGLHIASTHGH-YQMVEVLLGQGA-EINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
+ +T H A T+G +V+ LL Q IN ++G T LH A GH+ +V+ L
Sbjct: 301 ENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLL 360
Query: 1367 ESGASPKSETNL-NCAPIWFAASENHNDVLEYLLHKEHD 1404
++GA + NL C P + ++ L + K HD
Sbjct: 361 DNGA----DMNLVACDPSRSSGEKDEQTCLMWAYEKGHD 395
Score = 106 bits (255), Expect = 7e-22
Identities = 92/346 (26%), Positives = 156/346 (45%), Gaps = 28/346 (8%)
Query: 1033 LHLAA-ASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
LHL G+ + L+ G G +H A + +E++ L + +
Sbjct: 71 LHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGAD-IQQ 129
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
G T HIA I G ++ + L++ ++ ++ + TPL +AA GH V R+L
Sbjct: 130 VGYGGLTALHIATIAGHLEAADVLLQHGAN--VNIQDAVF-FTPLHIAAYYGHEQVTRLL 186
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDV-MRSTNTLRISSK-KLGLTPLHIAAYYG 1209
++ GA G +HLA+ G N+ + M + ++++ PLH + +G
Sbjct: 187 LKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFG 246
Query: 1210 QAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGV 1269
+ V+ LL +S+ +V + G TPLHLA YNG V + ++ +G
Sbjct: 247 HHDIVKYLL-------QSDLEVQPHVVNIYGD----TPLHLACYNGKFEVAKEIIQISGT 295
Query: 1270 QADAASNENGYNPLHLAC-FGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQM 1328
++ N H AC +G + +V LL ++ ++ R G TGLH A HGH ++
Sbjct: 296 ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL 355
Query: 1329 VEVLLGQGAEIN---------ATDKNGWTPLHCAAKAGHLNVVKLL 1365
V+ LL GA++N + +K+ T L A + GH +V LL
Sbjct: 356 VQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
Score = 100 bits (239), Expect = 6e-20
Identities = 59/167 (35%), Positives = 89/167 (53%), Gaps = 7/167 (4%)
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS-NENGYNPLHLACFGGHMSIVGLLLSR 1301
+G T LHLA Y N ++ LL+S AD G LH+A GH+ +LL
Sbjct: 100 NGFTALHLAVYKDNAELITSLLHSG---ADIQQVGYGGLTALHIATIAGHLEAADVLLQH 156
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNV 1361
A + + D T LHIA+ +GH Q+ +LL GA++N + + G PLH A+ G LN+
Sbjct: 157 GANV-NIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNI 215
Query: 1362 VKLLCESG--ASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQ 1406
KLL E G A ++ N + P+ F + H+D+++YLL + + Q
Sbjct: 216 AKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQ 262
Score = 90.2 bits (214), Expect = 7e-17
Identities = 96/368 (26%), Positives = 160/368 (43%), Gaps = 33/368 (8%)
Query: 833 ESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHET 892
E+ S ++ E+G S LH C I + ++ L+ G S TR N T
Sbjct: 53 EAFSKVNLNYRTENGLSLLHLCC--------ICGGKKSHIRTLMLKGLRPSRLTR-NGFT 103
Query: 893 AFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
A H N +++T ++ H S AD+ + G T L IA GH++ + LL +
Sbjct: 104 ALHLAVYKDNAELITSLL-H-SGADIQQV----GYGGLTALHIATIAGHLEAADVLLQHG 157
Query: 953 ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVK 1012
A V++ D + LH+AA +G+ QV LL A +N G LHLA+ G+ ++ K
Sbjct: 158 ANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAK 217
Query: 1013 FLIRD-HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID--ATDELGQKPIHAA 1069
L+ + A ++ + PLH + G ++ K LL+ + + G P+H A
Sbjct: 218 LLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLA 277
Query: 1070 AQNNYSEVVQLFLQ-QHPNLVMATTKDGNTCAHIAAIQG-SVKVIEELMKFDRTGVISAR 1127
N EV + +Q + T H A G S+ +++ L+ VI+
Sbjct: 278 CYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLD---QNVININ 334
Query: 1128 NKLNDS-TPLQLAAEGGHADVVRVLVRAGA-----SCTDENRAG----LTAVHLAAEHGH 1177
++ D T L A GH +V+ L+ GA +C +G T + A E GH
Sbjct: 335 HQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH 394
Query: 1178 TNVLDVMR 1185
++ +++
Sbjct: 395 DAIVTLLK 402
Score = 84.6 bits (200), Expect = 3e-15
Identities = 86/296 (29%), Positives = 137/296 (46%), Gaps = 27/296 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H A + +I +LL G + TALHIA + + LL +GA+
Sbjct: 100 NGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGAN 159
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V+I+ TPLHIAA ++ +LLK GA N + E G P+H+A+ G L
Sbjct: 160 VNIQDA-VFFTPLHIAAYY-GHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAK 217
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LL+E+G K V D PL R DIV++L++ D + +
Sbjct: 218 LLMEEGS----KADVNAQD-NEDHVPLHFCSRFGHHDIVKYLLQ--SDLEVQP------H 264
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
V+ G + LH AC K EV +++++ +G + + ETAFH G
Sbjct: 265 VVNIYGDTPLHLACYNGKFEVA-----KEIIQI---SGTESLTKENIFSETAFHSACTYG 316
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
+ +++ + +V +N Q G T L AC+ GH++LV LL N A +++
Sbjct: 317 KS---IDLVKFLLDQNVIN-INHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368
Score = 83.8 bits (198), Expect = 6e-15
Identities = 109/396 (27%), Positives = 173/396 (43%), Gaps = 42/396 (10%)
Query: 606 GNPTPVPTELLPIIWKP-ISKDSFYTLN-IDTAMELKSG-FFEDRMIFW-DTFFEK---- 657
GN PT+ WK +S+ T+ ++ +++K E R IF D F K
Sbjct: 2 GNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLN 61
Query: 658 YKHFDGARSIHTAARYG-HVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLL 716
Y+ +G +H G I TL+ KG T + +TALH+AV ++ +LL
Sbjct: 62 YRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL 121
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
GAD+ + G T LHIA I + A +LL+ GA N TP+H+AA +G+
Sbjct: 122 HSGADIQ-QVGYGGLTALHIAT-IAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 179
Query: 777 LATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVS 836
LLL+ G D +V G+ PL +A +I + L+E +G S
Sbjct: 180 EQVTRLLLKFGADVNVSGEV-------GDRPLHLASAKGFLNIAKLLME-----EG---S 224
Query: 837 TAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNH-ETAFH 895
A ++A D + LH+ + +VK L+++ +V + + +T H
Sbjct: 225 KADVNAQDNEDHVPLHFCSRF---------GHHDIVKYLLQSDLEVQPHVVNIYGDTPLH 275
Query: 896 YCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRG-HMQLVNTLL-TNHA 953
G +V E+I T +L ++N T AC G + LV LL N
Sbjct: 276 LACYNGKFEVAKEIIQISGT----ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVI 331
Query: 954 RVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
++ +G + LH A HG++++ LL N A +N
Sbjct: 332 NINHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN 367
Score = 83.0 bits (196), Expect = 1e-14
Identities = 56/189 (29%), Positives = 92/189 (48%), Gaps = 5/189 (2%)
Query: 1242 ESGLTPLHLAAY-NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLS 1300
E+GL+ LHL G ++ +R L+ G++ + NG+ LHLA + + ++ LL
Sbjct: 65 ENGLSLLHLCCICGGKKSHIRTLMLK-GLRPSRLTR-NGFTALHLAVYKDNAELITSLLH 122
Query: 1301 RSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
A++ G T LHIA+ GH + +VLL GA +N D +TPLH AA GH
Sbjct: 123 SGADI-QQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQ 181
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMV 1420
V +LL + GA + P+ A+++ ++ + L+ + D L
Sbjct: 182 VTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHF 241
Query: 1421 CSK-NHNNI 1428
CS+ H++I
Sbjct: 242 CSRFGHHDI 250
Score = 68.1 bits (159), Expect = 3e-10
Identities = 79/302 (26%), Positives = 141/302 (46%), Gaps = 35/302 (11%)
Query: 661 FDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
+ G ++H A GH+ + LLQ G +V++ +T LHIA V LL +GA
Sbjct: 132 YGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA 191
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSG--AGPNKATEDGMTPVHVAAKFGNLA 778
DV++ G+ + PLH+A+ A +L++ G A N + P+H ++FG+
Sbjct: 192 DVNV-SGEVGDRPLHLAS-AKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHD 249
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LL+ + ++ V IY G+TPL +AC + ++ + +I+ ES++
Sbjct: 250 IVKYLLQSDLE-VQPHVVNIY----GDTPLHLACYNGKFEVAKEIIQI---SGTESLTKE 301
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLI-ENGADVSLQTRHNHETAFHYC 897
I + +A H AC K +VK L+ +N +++ Q R H T H
Sbjct: 302 NIFS-----ETAFHSACTYGK--------SIDLVKFLLDQNVININHQGRDGH-TGLHSA 347
Query: 898 AIAGNNDVMTEMI-----AHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
G+ ++ ++ ++ D SR+ ++ T L+ A +GH +V TLL ++
Sbjct: 348 CYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDE--QTCLMWAYEKGHDAIV-TLLKHY 404
Query: 953 AR 954
R
Sbjct: 405 KR 406
Score = 67.3 bits (157), Expect = 6e-10
Identities = 56/195 (28%), Positives = 83/195 (42%), Gaps = 4/195 (2%)
Query: 28 QKDLQRLELSFIELNKERAKQKEWKKLIRDLVFQRGKVPL-LLAVEAGNQSMVRELLSAQ 86
+ DLQ E EL + + K+ + + G L L + G +S +R L+
Sbjct: 32 EDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKG 91
Query: 87 TAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPL 146
T G TALHLA + + ++ L+ GA + G T LHIA G
Sbjct: 92 LRPS--RLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEA 149
Query: 147 VKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIAS 206
AN I D TP+H+AA GH + LL KF A + + G +H+AS
Sbjct: 150 ADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLL-KFGADVNVSGEVGDRPLHLAS 208
Query: 207 LNGHADCAMMLFKKG 221
G + A +L ++G
Sbjct: 209 AKGFLNIAKLLMEEG 223
Score = 66.9 bits (156), Expect = 7e-10
Identities = 49/173 (28%), Positives = 79/173 (45%), Gaps = 5/173 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G L LAV N ++ LL + ++ G TALH+A ++ A +L+ +
Sbjct: 99 RNGFTALHLAVYKDNAELITSLL--HSGADIQQVGYGGLTALHIATIAGHLEAADVLLQH 156
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+ + TPLHIAA G E + + A+ ++ P+HLA+ G I
Sbjct: 157 GANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIA 216
Query: 181 ELLADK-FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG--VYLHMPNKY 230
+LL ++ KA + + + +H S GH D L + V H+ N Y
Sbjct: 217 KLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY 269
Score = 48.4 bits (110), Expect = 3e-04
Identities = 39/169 (23%), Positives = 67/169 (39%), Gaps = 5/169 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL LA G ++ + L+ + + A LH +R D+ + L+
Sbjct: 200 GDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDL 259
Query: 123 VVD--ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE--DRTPMHLAAENGHAA 178
V N G TPLH+A G + K + ++ T H A G +
Sbjct: 260 EVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSI 319
Query: 179 -IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHM 226
+++ L D+ +I + +DG T +H A +GH L G +++
Sbjct: 320 DLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368
Score = 44.8 bits (101), Expect = 0.003
Identities = 36/132 (27%), Positives = 56/132 (42%), Gaps = 11/132 (8%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARR-RDVDMARILVDYG 121
G PL LA G + +E++ E L +TA H A + +D+ + L+D
Sbjct: 270 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQN 329
Query: 122 AV-VDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIAD-------NEDRTPMHLA 171
+ ++ G T LH A G LV++ G N D +++T + A
Sbjct: 330 VININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWA 389
Query: 172 AENGHAAIIELL 183
E GH AI+ LL
Sbjct: 390 YEKGHDAIVTLL 401
Score = 33.5 bits (73), Expect = 8.3
Identities = 20/66 (30%), Positives = 34/66 (51%), Gaps = 1/66 (1%)
Query: 166 TPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
T +HLA +A +I L A I + G T +HIA++ GH + A +L + G ++
Sbjct: 103 TALHLAVYKDNAELITSLLHS-GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVN 161
Query: 226 MPNKYF 231
+ + F
Sbjct: 162 IQDAVF 167
>BC113539-1|AAI13540.1| 835|Homo sapiens TNNI3 interacting kinase
protein.
Length = 835
Score = 107 bits (256), Expect = 6e-22
Identities = 100/339 (29%), Positives = 146/339 (43%), Gaps = 34/339 (10%)
Query: 1093 TKDGNTCAHIAAIQGSVKV-IEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
T++G + H+ I G K I LM G+ +R N T L LA +A+++ L
Sbjct: 64 TENGLSLLHLCCICGGKKSHIRTLML---KGLRPSRLTRNGFTALHLAVYKDNAELITSL 120
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQA 1211
+ +GA GLTA+H+A GH DV+ + TPLHIAAYYG
Sbjct: 121 LHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE 180
Query: 1212 ETVRELLS-----HVPGTVKSE-----APTGVSLVPVLGAESGL------------TPLH 1249
+ R LL +V G V + G + L E G PLH
Sbjct: 181 QVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLH 240
Query: 1250 LAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSA-ELLHS 1308
+ G+ ++V+ LL S N G PLHLAC+ G + ++ S E L
Sbjct: 241 FCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTK 300
Query: 1309 TDRHGKTGLHIASTHGH-YQMVEVLLGQGA-EINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
+ +T H A T+G +V+ LL Q IN ++G T LH A GH+ +V+ L
Sbjct: 301 ENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLL 360
Query: 1367 ESGASPKSETNL-NCAPIWFAASENHNDVLEYLLHKEHD 1404
++GA + NL C P + ++ L + K HD
Sbjct: 361 DNGA----DMNLVACDPSRSSGEKDEQTCLMWAYEKGHD 395
Score = 106 bits (255), Expect = 7e-22
Identities = 92/346 (26%), Positives = 156/346 (45%), Gaps = 28/346 (8%)
Query: 1033 LHLAA-ASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
LHL G+ + L+ G G +H A + +E++ L + +
Sbjct: 71 LHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGAD-IQQ 129
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
G T HIA I G ++ + L++ ++ ++ + TPL +AA GH V R+L
Sbjct: 130 VGYGGLTALHIATIAGHLEAADVLLQHGAN--VNIQDAVF-FTPLHIAAYYGHEQVTRLL 186
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDV-MRSTNTLRISSK-KLGLTPLHIAAYYG 1209
++ GA G +HLA+ G N+ + M + ++++ PLH + +G
Sbjct: 187 LKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFG 246
Query: 1210 QAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGV 1269
+ V+ LL +S+ +V + G TPLHLA YNG V + ++ +G
Sbjct: 247 HHDIVKYLL-------QSDLEVQPHVVNIYGD----TPLHLACYNGKFEVAKEIIQISGT 295
Query: 1270 QADAASNENGYNPLHLAC-FGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQM 1328
++ N H AC +G + +V LL ++ ++ R G TGLH A HGH ++
Sbjct: 296 ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL 355
Query: 1329 VEVLLGQGAEIN---------ATDKNGWTPLHCAAKAGHLNVVKLL 1365
V+ LL GA++N + +K+ T L A + GH +V LL
Sbjct: 356 VQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
Score = 100 bits (239), Expect = 6e-20
Identities = 59/167 (35%), Positives = 89/167 (53%), Gaps = 7/167 (4%)
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS-NENGYNPLHLACFGGHMSIVGLLLSR 1301
+G T LHLA Y N ++ LL+S AD G LH+A GH+ +LL
Sbjct: 100 NGFTALHLAVYKDNAELITSLLHSG---ADIQQVGYGGLTALHIATIAGHLEAADVLLQH 156
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNV 1361
A + + D T LHIA+ +GH Q+ +LL GA++N + + G PLH A+ G LN+
Sbjct: 157 GANV-NIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNI 215
Query: 1362 VKLLCESG--ASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQ 1406
KLL E G A ++ N + P+ F + H+D+++YLL + + Q
Sbjct: 216 AKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQ 262
Score = 90.2 bits (214), Expect = 7e-17
Identities = 96/368 (26%), Positives = 160/368 (43%), Gaps = 33/368 (8%)
Query: 833 ESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHET 892
E+ S ++ E+G S LH C I + ++ L+ G S TR N T
Sbjct: 53 EAFSKVNLNYRTENGLSLLHLCC--------ICGGKKSHIRTLMLKGLRPSRLTR-NGFT 103
Query: 893 AFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
A H N +++T ++ H S AD+ + G T L IA GH++ + LL +
Sbjct: 104 ALHLAVYKDNAELITSLL-H-SGADIQQV----GYGGLTALHIATIAGHLEAADVLLQHG 157
Query: 953 ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVK 1012
A V++ D + LH+AA +G+ QV LL A +N G LHLA+ G+ ++ K
Sbjct: 158 ANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAK 217
Query: 1013 FLIRD-HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID--ATDELGQKPIHAA 1069
L+ + A ++ + PLH + G ++ K LL+ + + G P+H A
Sbjct: 218 LLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLA 277
Query: 1070 AQNNYSEVVQLFLQ-QHPNLVMATTKDGNTCAHIAAIQG-SVKVIEELMKFDRTGVISAR 1127
N EV + +Q + T H A G S+ +++ L+ VI+
Sbjct: 278 CYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLD---QNVININ 334
Query: 1128 NKLNDS-TPLQLAAEGGHADVVRVLVRAGA-----SCTDENRAG----LTAVHLAAEHGH 1177
++ D T L A GH +V+ L+ GA +C +G T + A E GH
Sbjct: 335 HQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH 394
Query: 1178 TNVLDVMR 1185
++ +++
Sbjct: 395 DAIVTLLK 402
Score = 84.6 bits (200), Expect = 3e-15
Identities = 86/296 (29%), Positives = 137/296 (46%), Gaps = 27/296 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H A + +I +LL G + TALHIA + + LL +GA+
Sbjct: 100 NGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGAN 159
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V+I+ TPLHIAA ++ +LLK GA N + E G P+H+A+ G L
Sbjct: 160 VNIQDA-VFFTPLHIAAYY-GHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAK 217
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LL+E+G K V D PL R DIV++L++ D + +
Sbjct: 218 LLMEEGS----KADVNAQD-NEDHVPLHFCSRFGHHDIVKYLLQ--SDLEVQP------H 264
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
V+ G + LH AC K EV +++++ +G + + ETAFH G
Sbjct: 265 VVNIYGDTPLHLACYNGKFEVA-----KEIIQI---SGTESLTKENIFSETAFHSACTYG 316
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
+ +++ + +V +N Q G T L AC+ GH++LV LL N A +++
Sbjct: 317 KS---IDLVKFLLDQNVIN-INHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368
Score = 83.8 bits (198), Expect = 6e-15
Identities = 109/396 (27%), Positives = 173/396 (43%), Gaps = 42/396 (10%)
Query: 606 GNPTPVPTELLPIIWKP-ISKDSFYTLN-IDTAMELKSG-FFEDRMIFW-DTFFEK---- 657
GN PT+ WK +S+ T+ ++ +++K E R IF D F K
Sbjct: 2 GNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLN 61
Query: 658 YKHFDGARSIHTAARYG-HVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLL 716
Y+ +G +H G I TL+ KG T + +TALH+AV ++ +LL
Sbjct: 62 YRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL 121
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
GAD+ + G T LHIA I + A +LL+ GA N TP+H+AA +G+
Sbjct: 122 HSGADIQ-QVGYGGLTALHIAT-IAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 179
Query: 777 LATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVS 836
LLL+ G D +V G+ PL +A +I + L+E +G S
Sbjct: 180 EQVTRLLLKFGADVNVSGEV-------GDRPLHLASAKGFLNIAKLLME-----EG---S 224
Query: 837 TAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNH-ETAFH 895
A ++A D + LH+ + +VK L+++ +V + + +T H
Sbjct: 225 KADVNAQDNEDHVPLHFCSRF---------GHHDIVKYLLQSDLEVQPHVVNIYGDTPLH 275
Query: 896 YCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRG-HMQLVNTLL-TNHA 953
G +V E+I T +L ++N T AC G + LV LL N
Sbjct: 276 LACYNGKFEVAKEIIQISGT----ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVI 331
Query: 954 RVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
++ +G + LH A HG++++ LL N A +N
Sbjct: 332 NINHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN 367
Score = 83.0 bits (196), Expect = 1e-14
Identities = 56/189 (29%), Positives = 92/189 (48%), Gaps = 5/189 (2%)
Query: 1242 ESGLTPLHLAAY-NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLS 1300
E+GL+ LHL G ++ +R L+ G++ + NG+ LHLA + + ++ LL
Sbjct: 65 ENGLSLLHLCCICGGKKSHIRTLMLK-GLRPSRLTR-NGFTALHLAVYKDNAELITSLLH 122
Query: 1301 RSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
A++ G T LHIA+ GH + +VLL GA +N D +TPLH AA GH
Sbjct: 123 SGADI-QQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQ 181
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMV 1420
V +LL + GA + P+ A+++ ++ + L+ + D L
Sbjct: 182 VTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHF 241
Query: 1421 CSK-NHNNI 1428
CS+ H++I
Sbjct: 242 CSRFGHHDI 250
Score = 68.1 bits (159), Expect = 3e-10
Identities = 79/302 (26%), Positives = 141/302 (46%), Gaps = 35/302 (11%)
Query: 661 FDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
+ G ++H A GH+ + LLQ G +V++ +T LHIA V LL +GA
Sbjct: 132 YGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA 191
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSG--AGPNKATEDGMTPVHVAAKFGNLA 778
DV++ G+ + PLH+A+ A +L++ G A N + P+H ++FG+
Sbjct: 192 DVNV-SGEVGDRPLHLAS-AKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHD 249
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LL+ + ++ V IY G+TPL +AC + ++ + +I+ ES++
Sbjct: 250 IVKYLLQSDLE-VQPHVVNIY----GDTPLHLACYNGKFEVAKEIIQI---SGTESLTKE 301
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLI-ENGADVSLQTRHNHETAFHYC 897
I + +A H AC K +VK L+ +N +++ Q R H T H
Sbjct: 302 NIFS-----ETAFHSACTYGK--------SIDLVKFLLDQNVININHQGRDGH-TGLHSA 347
Query: 898 AIAGNNDVMTEMI-----AHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
G+ ++ ++ ++ D SR+ ++ T L+ A +GH +V TLL ++
Sbjct: 348 CYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDE--QTCLMWAYEKGHDAIV-TLLKHY 404
Query: 953 AR 954
R
Sbjct: 405 KR 406
Score = 67.3 bits (157), Expect = 6e-10
Identities = 56/195 (28%), Positives = 83/195 (42%), Gaps = 4/195 (2%)
Query: 28 QKDLQRLELSFIELNKERAKQKEWKKLIRDLVFQRGKVPL-LLAVEAGNQSMVRELLSAQ 86
+ DLQ E EL + + K+ + + G L L + G +S +R L+
Sbjct: 32 EDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKG 91
Query: 87 TAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPL 146
T G TALHLA + + ++ L+ GA + G T LHIA G
Sbjct: 92 LRPS--RLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEA 149
Query: 147 VKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIAS 206
AN I D TP+H+AA GH + LL KF A + + G +H+AS
Sbjct: 150 ADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLL-KFGADVNVSGEVGDRPLHLAS 208
Query: 207 LNGHADCAMMLFKKG 221
G + A +L ++G
Sbjct: 209 AKGFLNIAKLLMEEG 223
Score = 66.9 bits (156), Expect = 7e-10
Identities = 49/173 (28%), Positives = 79/173 (45%), Gaps = 5/173 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G L LAV N ++ LL + ++ G TALH+A ++ A +L+ +
Sbjct: 99 RNGFTALHLAVYKDNAELITSLL--HSGADIQQVGYGGLTALHIATIAGHLEAADVLLQH 156
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+ + TPLHIAA G E + + A+ ++ P+HLA+ G I
Sbjct: 157 GANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIA 216
Query: 181 ELLADK-FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG--VYLHMPNKY 230
+LL ++ KA + + + +H S GH D L + V H+ N Y
Sbjct: 217 KLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY 269
Score = 48.4 bits (110), Expect = 3e-04
Identities = 39/169 (23%), Positives = 67/169 (39%), Gaps = 5/169 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL LA G ++ + L+ + + A LH +R D+ + L+
Sbjct: 200 GDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDL 259
Query: 123 VVD--ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE--DRTPMHLAAENGHAA 178
V N G TPLH+A G + K + ++ T H A G +
Sbjct: 260 EVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSI 319
Query: 179 -IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHM 226
+++ L D+ +I + +DG T +H A +GH L G +++
Sbjct: 320 DLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368
Score = 44.8 bits (101), Expect = 0.003
Identities = 36/132 (27%), Positives = 56/132 (42%), Gaps = 11/132 (8%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARR-RDVDMARILVDYG 121
G PL LA G + +E++ E L +TA H A + +D+ + L+D
Sbjct: 270 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQN 329
Query: 122 AV-VDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIAD-------NEDRTPMHLA 171
+ ++ G T LH A G LV++ G N D +++T + A
Sbjct: 330 VININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWA 389
Query: 172 AENGHAAIIELL 183
E GH AI+ LL
Sbjct: 390 YEKGHDAIVTLL 401
Score = 33.5 bits (73), Expect = 8.3
Identities = 20/66 (30%), Positives = 34/66 (51%), Gaps = 1/66 (1%)
Query: 166 TPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
T +HLA +A +I L A I + G T +HIA++ GH + A +L + G ++
Sbjct: 103 TALHLAVYKDNAELITSLLHS-GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVN 161
Query: 226 MPNKYF 231
+ + F
Sbjct: 162 IQDAVF 167
>BC032865-1|AAH32865.1| 843|Homo sapiens TNNI3K protein protein.
Length = 843
Score = 107 bits (256), Expect = 6e-22
Identities = 100/339 (29%), Positives = 146/339 (43%), Gaps = 34/339 (10%)
Query: 1093 TKDGNTCAHIAAIQGSVKV-IEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
T++G + H+ I G K I LM G+ +R N T L LA +A+++ L
Sbjct: 165 TENGLSLLHLCCICGGKKSHIRTLML---KGLRPSRLTRNGFTALHLAVYKDNAELITSL 221
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQA 1211
+ +GA GLTA+H+A GH DV+ + TPLHIAAYYG
Sbjct: 222 LHSGADVQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE 281
Query: 1212 ETVRELLS-----HVPGTVKSE-----APTGVSLVPVLGAESGL------------TPLH 1249
+ R LL +V G V + G + L E G PLH
Sbjct: 282 QVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLH 341
Query: 1250 LAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSA-ELLHS 1308
+ G+ ++V+ LL S N G PLHLAC+ G + ++ S E L
Sbjct: 342 FCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTK 401
Query: 1309 TDRHGKTGLHIASTHGH-YQMVEVLLGQGA-EINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
+ +T H A T+G +V+ LL Q IN ++G T LH A GH+ +V+ L
Sbjct: 402 ENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLL 461
Query: 1367 ESGASPKSETNL-NCAPIWFAASENHNDVLEYLLHKEHD 1404
++GA + NL C P + ++ L + K HD
Sbjct: 462 DNGA----DMNLVACDPSRSSGEKDEQTCLMWAYEKGHD 496
Score = 107 bits (256), Expect = 6e-22
Identities = 93/346 (26%), Positives = 156/346 (45%), Gaps = 28/346 (8%)
Query: 1033 LHLAA-ASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
LHL G+ + L+ G G +H A + +E++ L + V
Sbjct: 172 LHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGAD-VQQ 230
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
G T HIA I G ++ + L++ ++ ++ + TPL +AA GH V R+L
Sbjct: 231 VGYGGLTALHIATIAGHLEAADVLLQHGAN--VNIQDAVF-FTPLHIAAYYGHEQVTRLL 287
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDV-MRSTNTLRISSK-KLGLTPLHIAAYYG 1209
++ GA G +HLA+ G N+ + M + ++++ PLH + +G
Sbjct: 288 LKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFG 347
Query: 1210 QAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGV 1269
+ V+ LL +S+ +V + G TPLHLA YNG V + ++ +G
Sbjct: 348 HHDIVKYLL-------QSDLEVQPHVVNIYGD----TPLHLACYNGKFEVAKEIIQISGT 396
Query: 1270 QADAASNENGYNPLHLAC-FGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQM 1328
++ N H AC +G + +V LL ++ ++ R G TGLH A HGH ++
Sbjct: 397 ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL 456
Query: 1329 VEVLLGQGAEIN---------ATDKNGWTPLHCAAKAGHLNVVKLL 1365
V+ LL GA++N + +K+ T L A + GH +V LL
Sbjct: 457 VQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502
Score = 100 bits (240), Expect = 5e-20
Identities = 59/167 (35%), Positives = 89/167 (53%), Gaps = 7/167 (4%)
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS-NENGYNPLHLACFGGHMSIVGLLLSR 1301
+G T LHLA Y N ++ LL+S AD G LH+A GH+ +LL
Sbjct: 201 NGFTALHLAVYKDNAELITSLLHSG---ADVQQVGYGGLTALHIATIAGHLEAADVLLQH 257
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNV 1361
A + + D T LHIA+ +GH Q+ +LL GA++N + + G PLH A+ G LN+
Sbjct: 258 GANV-NIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNI 316
Query: 1362 VKLLCESG--ASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQ 1406
KLL E G A ++ N + P+ F + H+D+++YLL + + Q
Sbjct: 317 AKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQ 363
Score = 90.6 bits (215), Expect = 5e-17
Identities = 97/368 (26%), Positives = 160/368 (43%), Gaps = 33/368 (8%)
Query: 833 ESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHET 892
E+ S ++ E+G S LH C I + ++ L+ G S TR N T
Sbjct: 154 EAFSKVNLNYRTENGLSLLHLCC--------ICGGKKSHIRTLMLKGLRPSRLTR-NGFT 204
Query: 893 AFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
A H N +++T ++ H S ADV + G T L IA GH++ + LL +
Sbjct: 205 ALHLAVYKDNAELITSLL-H-SGADVQQV----GYGGLTALHIATIAGHLEAADVLLQHG 258
Query: 953 ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVK 1012
A V++ D + LH+AA +G+ QV LL A +N G LHLA+ G+ ++ K
Sbjct: 259 ANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAK 318
Query: 1013 FLIRD-HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID--ATDELGQKPIHAA 1069
L+ + A ++ + PLH + G ++ K LL+ + + G P+H A
Sbjct: 319 LLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLA 378
Query: 1070 AQNNYSEVVQLFLQ-QHPNLVMATTKDGNTCAHIAAIQG-SVKVIEELMKFDRTGVISAR 1127
N EV + +Q + T H A G S+ +++ L+ VI+
Sbjct: 379 CYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLD---QNVININ 435
Query: 1128 NKLNDS-TPLQLAAEGGHADVVRVLVRAGA-----SCTDENRAG----LTAVHLAAEHGH 1177
++ D T L A GH +V+ L+ GA +C +G T + A E GH
Sbjct: 436 HQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH 495
Query: 1178 TNVLDVMR 1185
++ +++
Sbjct: 496 DAIVTLLK 503
Score = 85.0 bits (201), Expect = 3e-15
Identities = 87/296 (29%), Positives = 137/296 (46%), Gaps = 27/296 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H A + +I +LL G V TALHIA + + LL +GA+
Sbjct: 201 NGFTALHLAVYKDNAELITSLLHSGADVQQVGYGGLTALHIATIAGHLEAADVLLQHGAN 260
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V+I+ TPLHIAA ++ +LLK GA N + E G P+H+A+ G L
Sbjct: 261 VNIQDA-VFFTPLHIAAYY-GHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAK 318
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LL+E+G K V D PL R DIV++L++ D + +
Sbjct: 319 LLMEEGS----KADVNAQD-NEDHVPLHFCSRFGHHDIVKYLLQ--SDLEVQP------H 365
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
V+ G + LH AC K EV +++++ +G + + ETAFH G
Sbjct: 366 VVNIYGDTPLHLACYNGKFEVA-----KEIIQI---SGTESLTKENIFSETAFHSACTYG 417
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
+ +++ + +V +N Q G T L AC+ GH++LV LL N A +++
Sbjct: 418 KS---IDLVKFLLDQNVIN-INHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 469
Score = 82.6 bits (195), Expect = 1e-14
Identities = 56/189 (29%), Positives = 92/189 (48%), Gaps = 5/189 (2%)
Query: 1242 ESGLTPLHLAAY-NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLS 1300
E+GL+ LHL G ++ +R L+ G++ + NG+ LHLA + + ++ LL
Sbjct: 166 ENGLSLLHLCCICGGKKSHIRTLMLK-GLRPSRLTR-NGFTALHLAVYKDNAELITSLLH 223
Query: 1301 RSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
A++ G T LHIA+ GH + +VLL GA +N D +TPLH AA GH
Sbjct: 224 SGADV-QQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQ 282
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMV 1420
V +LL + GA + P+ A+++ ++ + L+ + D L
Sbjct: 283 VTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHF 342
Query: 1421 CSK-NHNNI 1428
CS+ H++I
Sbjct: 343 CSRFGHHDI 351
Score = 81.0 bits (191), Expect = 4e-14
Identities = 90/314 (28%), Positives = 141/314 (44%), Gaps = 33/314 (10%)
Query: 679 INTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAA 738
I TL+ KG T + +TALH+AV ++ +LL GADV + G T LHIA
Sbjct: 185 IRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADVQ-QVGYGGLTALHIAT 243
Query: 739 RIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCI 798
I + A +LL+ GA N TP+H+AA +G+ LLL+ G D +V
Sbjct: 244 -IAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEV-- 300
Query: 799 YDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVT 858
G+ PL +A +I + L+E +G S A ++A D + LH+ +
Sbjct: 301 -----GDRPLHLASAKGFLNIAKLLME-----EG---SKADVNAQDNEDHVPLHFCSRF- 346
Query: 859 KEEVKIPTADRQVVKCLIENGADVSLQTRHNH-ETAFHYCAIAGNNDVMTEMIAHISTAD 917
+VK L+++ +V + + +T H G +V E+I T
Sbjct: 347 --------GHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGT-- 396
Query: 918 VSRALNRQNSIGWTPLLIACHRG-HMQLVNTLL-TNHARVDVFDVEGRSALHLAAEHGYL 975
+L ++N T AC G + LV LL N ++ +G + LH A HG++
Sbjct: 397 --ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHI 454
Query: 976 QVCDALLTNKAFIN 989
++ LL N A +N
Sbjct: 455 RLVQFLLDNGADMN 468
Score = 68.1 bits (159), Expect = 3e-10
Identities = 79/302 (26%), Positives = 141/302 (46%), Gaps = 35/302 (11%)
Query: 661 FDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
+ G ++H A GH+ + LLQ G +V++ +T LHIA V LL +GA
Sbjct: 233 YGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA 292
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSG--AGPNKATEDGMTPVHVAAKFGNLA 778
DV++ G+ + PLH+A+ A +L++ G A N + P+H ++FG+
Sbjct: 293 DVNV-SGEVGDRPLHLAS-AKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHD 350
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LL+ + ++ V IY G+TPL +AC + ++ + +I+ ES++
Sbjct: 351 IVKYLLQSDLE-VQPHVVNIY----GDTPLHLACYNGKFEVAKEIIQI---SGTESLTKE 402
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLI-ENGADVSLQTRHNHETAFHYC 897
I + +A H AC K +VK L+ +N +++ Q R H T H
Sbjct: 403 NIFS-----ETAFHSACTYGK--------SIDLVKFLLDQNVININHQGRDGH-TGLHSA 448
Query: 898 AIAGNNDVMTEMI-----AHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
G+ ++ ++ ++ D SR+ ++ T L+ A +GH +V TLL ++
Sbjct: 449 CYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDE--QTCLMWAYEKGHDAIV-TLLKHY 505
Query: 953 AR 954
R
Sbjct: 506 KR 507
Score = 67.7 bits (158), Expect = 4e-10
Identities = 57/195 (29%), Positives = 83/195 (42%), Gaps = 4/195 (2%)
Query: 28 QKDLQRLELSFIELNKERAKQKEWKKLIRDLVFQRGKVPL-LLAVEAGNQSMVRELLSAQ 86
+ DLQ E EL + + K+ + + G L L + G +S +R L+
Sbjct: 133 EDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKG 192
Query: 87 TAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPL 146
T G TALHLA + + ++ L+ GA V G T LHIA G
Sbjct: 193 LRPS--RLTRNGFTALHLAVYKDNAELITSLLHSGADVQQVGYGGLTALHIATIAGHLEA 250
Query: 147 VKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIAS 206
AN I D TP+H+AA GH + LL KF A + + G +H+AS
Sbjct: 251 ADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLL-KFGADVNVSGEVGDRPLHLAS 309
Query: 207 LNGHADCAMMLFKKG 221
G + A +L ++G
Sbjct: 310 AKGFLNIAKLLMEEG 324
Score = 66.5 bits (155), Expect = 1e-09
Identities = 49/173 (28%), Positives = 79/173 (45%), Gaps = 5/173 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G L LAV N ++ LL + ++ G TALH+A ++ A +L+ +
Sbjct: 200 RNGFTALHLAVYKDNAELITSLL--HSGADVQQVGYGGLTALHIATIAGHLEAADVLLQH 257
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+ + TPLHIAA G E + + A+ ++ P+HLA+ G I
Sbjct: 258 GANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIA 317
Query: 181 ELLADK-FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG--VYLHMPNKY 230
+LL ++ KA + + + +H S GH D L + V H+ N Y
Sbjct: 318 KLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY 370
Score = 48.4 bits (110), Expect = 3e-04
Identities = 39/169 (23%), Positives = 67/169 (39%), Gaps = 5/169 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL LA G ++ + L+ + + A LH +R D+ + L+
Sbjct: 301 GDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDL 360
Query: 123 VVD--ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE--DRTPMHLAAENGHAA 178
V N G TPLH+A G + K + ++ T H A G +
Sbjct: 361 EVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSI 420
Query: 179 -IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHM 226
+++ L D+ +I + +DG T +H A +GH L G +++
Sbjct: 421 DLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 469
Score = 44.8 bits (101), Expect = 0.003
Identities = 36/132 (27%), Positives = 56/132 (42%), Gaps = 11/132 (8%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARR-RDVDMARILVDYG 121
G PL LA G + +E++ E L +TA H A + +D+ + L+D
Sbjct: 371 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQN 430
Query: 122 AV-VDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIAD-------NEDRTPMHLA 171
+ ++ G T LH A G LV++ G N D +++T + A
Sbjct: 431 VININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWA 490
Query: 172 AENGHAAIIELL 183
E GH AI+ LL
Sbjct: 491 YEKGHDAIVTLL 502
>AY303691-1|AAP72030.1| 835|Homo sapiens cardiac ankyrin repeat
kinase protein.
Length = 835
Score = 107 bits (256), Expect = 6e-22
Identities = 100/339 (29%), Positives = 146/339 (43%), Gaps = 34/339 (10%)
Query: 1093 TKDGNTCAHIAAIQGSVKV-IEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
T++G + H+ I G K I LM G+ +R N T L LA +A+++ L
Sbjct: 64 TENGLSLLHLCCICGGKKSHIRTLML---KGLRPSRLTRNGFTALHLAVYKDNAELITSL 120
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQA 1211
+ +GA GLTA+H+A GH DV+ + TPLHIAAYYG
Sbjct: 121 LHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE 180
Query: 1212 ETVRELLS-----HVPGTVKSE-----APTGVSLVPVLGAESGL------------TPLH 1249
+ R LL +V G V + G + L E G PLH
Sbjct: 181 QVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLH 240
Query: 1250 LAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSA-ELLHS 1308
+ G+ ++V+ LL S N G PLHLAC+ G + ++ S E L
Sbjct: 241 FCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTK 300
Query: 1309 TDRHGKTGLHIASTHGH-YQMVEVLLGQGA-EINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
+ +T H A T+G +V+ LL Q IN ++G T LH A GH+ +V+ L
Sbjct: 301 ENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLL 360
Query: 1367 ESGASPKSETNL-NCAPIWFAASENHNDVLEYLLHKEHD 1404
++GA + NL C P + ++ L + K HD
Sbjct: 361 DNGA----DMNLVACDPSRSSGEKDEQTCLMWAYEKGHD 395
Score = 106 bits (255), Expect = 7e-22
Identities = 92/346 (26%), Positives = 156/346 (45%), Gaps = 28/346 (8%)
Query: 1033 LHLAA-ASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
LHL G+ + L+ G G +H A + +E++ L + +
Sbjct: 71 LHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGAD-IQQ 129
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
G T HIA I G ++ + L++ ++ ++ + TPL +AA GH V R+L
Sbjct: 130 VGYGGLTALHIATIAGHLEAADVLLQHGAN--VNIQDAVF-FTPLHIAAYYGHEQVTRLL 186
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDV-MRSTNTLRISSK-KLGLTPLHIAAYYG 1209
++ GA G +HLA+ G N+ + M + ++++ PLH + +G
Sbjct: 187 LKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFG 246
Query: 1210 QAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGV 1269
+ V+ LL +S+ +V + G TPLHLA YNG V + ++ +G
Sbjct: 247 HHDIVKYLL-------QSDLEVQPHVVNIYGD----TPLHLACYNGKFEVAKEIIQISGT 295
Query: 1270 QADAASNENGYNPLHLAC-FGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQM 1328
++ N H AC +G + +V LL ++ ++ R G TGLH A HGH ++
Sbjct: 296 ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL 355
Query: 1329 VEVLLGQGAEIN---------ATDKNGWTPLHCAAKAGHLNVVKLL 1365
V+ LL GA++N + +K+ T L A + GH +V LL
Sbjct: 356 VQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
Score = 100 bits (239), Expect = 6e-20
Identities = 59/167 (35%), Positives = 89/167 (53%), Gaps = 7/167 (4%)
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS-NENGYNPLHLACFGGHMSIVGLLLSR 1301
+G T LHLA Y N ++ LL+S AD G LH+A GH+ +LL
Sbjct: 100 NGFTALHLAVYKDNAELITSLLHSG---ADIQQVGYGGLTALHIATIAGHLEAADVLLQH 156
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNV 1361
A + + D T LHIA+ +GH Q+ +LL GA++N + + G PLH A+ G LN+
Sbjct: 157 GANV-NIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNI 215
Query: 1362 VKLLCESG--ASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQ 1406
KLL E G A ++ N + P+ F + H+D+++YLL + + Q
Sbjct: 216 AKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQ 262
Score = 90.2 bits (214), Expect = 7e-17
Identities = 96/368 (26%), Positives = 160/368 (43%), Gaps = 33/368 (8%)
Query: 833 ESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHET 892
E+ S ++ E+G S LH C I + ++ L+ G S TR N T
Sbjct: 53 EAFSKVNLNYRTENGLSLLHLCC--------ICGGKKSHIRTLMLKGLRPSRLTR-NGFT 103
Query: 893 AFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
A H N +++T ++ H S AD+ + G T L IA GH++ + LL +
Sbjct: 104 ALHLAVYKDNAELITSLL-H-SGADIQQV----GYGGLTALHIATIAGHLEAADVLLQHG 157
Query: 953 ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVK 1012
A V++ D + LH+AA +G+ QV LL A +N G LHLA+ G+ ++ K
Sbjct: 158 ANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAK 217
Query: 1013 FLIRD-HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID--ATDELGQKPIHAA 1069
L+ + A ++ + PLH + G ++ K LL+ + + G P+H A
Sbjct: 218 LLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLA 277
Query: 1070 AQNNYSEVVQLFLQ-QHPNLVMATTKDGNTCAHIAAIQG-SVKVIEELMKFDRTGVISAR 1127
N EV + +Q + T H A G S+ +++ L+ VI+
Sbjct: 278 CYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLD---QNVININ 334
Query: 1128 NKLNDS-TPLQLAAEGGHADVVRVLVRAGA-----SCTDENRAG----LTAVHLAAEHGH 1177
++ D T L A GH +V+ L+ GA +C +G T + A E GH
Sbjct: 335 HQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH 394
Query: 1178 TNVLDVMR 1185
++ +++
Sbjct: 395 DAIVTLLK 402
Score = 84.6 bits (200), Expect = 3e-15
Identities = 86/296 (29%), Positives = 137/296 (46%), Gaps = 27/296 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H A + +I +LL G + TALHIA + + LL +GA+
Sbjct: 100 NGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGAN 159
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V+I+ TPLHIAA ++ +LLK GA N + E G P+H+A+ G L
Sbjct: 160 VNIQDA-VFFTPLHIAAYY-GHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAK 217
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LL+E+G K V D PL R DIV++L++ D + +
Sbjct: 218 LLMEEGS----KADVNAQD-NEDHVPLHFCSRFGHHDIVKYLLQ--SDLEVQP------H 264
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
V+ G + LH AC K EV +++++ +G + + ETAFH G
Sbjct: 265 VVNIYGDTPLHLACYNGKFEVA-----KEIIQI---SGTESLTKENIFSETAFHSACTYG 316
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
+ +++ + +V +N Q G T L AC+ GH++LV LL N A +++
Sbjct: 317 KS---IDLVKFLLDQNVIN-INHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368
Score = 83.8 bits (198), Expect = 6e-15
Identities = 109/396 (27%), Positives = 173/396 (43%), Gaps = 42/396 (10%)
Query: 606 GNPTPVPTELLPIIWKP-ISKDSFYTLN-IDTAMELKSG-FFEDRMIFW-DTFFEK---- 657
GN PT+ WK +S+ T+ ++ +++K E R IF D F K
Sbjct: 2 GNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLN 61
Query: 658 YKHFDGARSIHTAARYG-HVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLL 716
Y+ +G +H G I TL+ KG T + +TALH+AV ++ +LL
Sbjct: 62 YRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL 121
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
GAD+ + G T LHIA I + A +LL+ GA N TP+H+AA +G+
Sbjct: 122 HSGADIQ-QVGYGGLTALHIAT-IAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 179
Query: 777 LATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVS 836
LLL+ G D +V G+ PL +A +I + L+E +G S
Sbjct: 180 EQVTRLLLKFGADVNVSGEV-------GDRPLHLASAKGFLNIAKLLME-----EG---S 224
Query: 837 TAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNH-ETAFH 895
A ++A D + LH+ + +VK L+++ +V + + +T H
Sbjct: 225 KADVNAQDNEDHVPLHFCSRF---------GHHDIVKYLLQSDLEVQPHVVNIYGDTPLH 275
Query: 896 YCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRG-HMQLVNTLL-TNHA 953
G +V E+I T +L ++N T AC G + LV LL N
Sbjct: 276 LACYNGKFEVAKEIIQISGT----ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVI 331
Query: 954 RVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
++ +G + LH A HG++++ LL N A +N
Sbjct: 332 NINHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN 367
Score = 83.0 bits (196), Expect = 1e-14
Identities = 56/189 (29%), Positives = 92/189 (48%), Gaps = 5/189 (2%)
Query: 1242 ESGLTPLHLAAY-NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLS 1300
E+GL+ LHL G ++ +R L+ G++ + NG+ LHLA + + ++ LL
Sbjct: 65 ENGLSLLHLCCICGGKKSHIRTLMLK-GLRPSRLTR-NGFTALHLAVYKDNAELITSLLH 122
Query: 1301 RSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
A++ G T LHIA+ GH + +VLL GA +N D +TPLH AA GH
Sbjct: 123 SGADI-QQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQ 181
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMV 1420
V +LL + GA + P+ A+++ ++ + L+ + D L
Sbjct: 182 VTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHF 241
Query: 1421 CSK-NHNNI 1428
CS+ H++I
Sbjct: 242 CSRFGHHDI 250
Score = 68.1 bits (159), Expect = 3e-10
Identities = 79/302 (26%), Positives = 141/302 (46%), Gaps = 35/302 (11%)
Query: 661 FDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
+ G ++H A GH+ + LLQ G +V++ +T LHIA V LL +GA
Sbjct: 132 YGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA 191
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSG--AGPNKATEDGMTPVHVAAKFGNLA 778
DV++ G+ + PLH+A+ A +L++ G A N + P+H ++FG+
Sbjct: 192 DVNV-SGEVGDRPLHLAS-AKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHD 249
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LL+ + ++ V IY G+TPL +AC + ++ + +I+ ES++
Sbjct: 250 IVKYLLQSDLE-VQPHVVNIY----GDTPLHLACYNGKFEVAKEIIQI---SGTESLTKE 301
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLI-ENGADVSLQTRHNHETAFHYC 897
I + +A H AC K +VK L+ +N +++ Q R H T H
Sbjct: 302 NIFS-----ETAFHSACTYGK--------SIDLVKFLLDQNVININHQGRDGH-TGLHSA 347
Query: 898 AIAGNNDVMTEMI-----AHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
G+ ++ ++ ++ D SR+ ++ T L+ A +GH +V TLL ++
Sbjct: 348 CYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDE--QTCLMWAYEKGHDAIV-TLLKHY 404
Query: 953 AR 954
R
Sbjct: 405 KR 406
Score = 67.3 bits (157), Expect = 6e-10
Identities = 56/195 (28%), Positives = 83/195 (42%), Gaps = 4/195 (2%)
Query: 28 QKDLQRLELSFIELNKERAKQKEWKKLIRDLVFQRGKVPL-LLAVEAGNQSMVRELLSAQ 86
+ DLQ E EL + + K+ + + G L L + G +S +R L+
Sbjct: 32 EDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKG 91
Query: 87 TAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPL 146
T G TALHLA + + ++ L+ GA + G T LHIA G
Sbjct: 92 LRPS--RLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEA 149
Query: 147 VKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIAS 206
AN I D TP+H+AA GH + LL KF A + + G +H+AS
Sbjct: 150 ADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLL-KFGADVNVSGEVGDRPLHLAS 208
Query: 207 LNGHADCAMMLFKKG 221
G + A +L ++G
Sbjct: 209 AKGFLNIAKLLMEEG 223
Score = 66.9 bits (156), Expect = 7e-10
Identities = 49/173 (28%), Positives = 79/173 (45%), Gaps = 5/173 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G L LAV N ++ LL + ++ G TALH+A ++ A +L+ +
Sbjct: 99 RNGFTALHLAVYKDNAELITSLL--HSGADIQQVGYGGLTALHIATIAGHLEAADVLLQH 156
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+ + TPLHIAA G E + + A+ ++ P+HLA+ G I
Sbjct: 157 GANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIA 216
Query: 181 ELLADK-FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG--VYLHMPNKY 230
+LL ++ KA + + + +H S GH D L + V H+ N Y
Sbjct: 217 KLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY 269
Score = 48.4 bits (110), Expect = 3e-04
Identities = 39/169 (23%), Positives = 67/169 (39%), Gaps = 5/169 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL LA G ++ + L+ + + A LH +R D+ + L+
Sbjct: 200 GDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDL 259
Query: 123 VVD--ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE--DRTPMHLAAENGHAA 178
V N G TPLH+A G + K + ++ T H A G +
Sbjct: 260 EVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSI 319
Query: 179 -IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHM 226
+++ L D+ +I + +DG T +H A +GH L G +++
Sbjct: 320 DLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368
Score = 44.8 bits (101), Expect = 0.003
Identities = 36/132 (27%), Positives = 56/132 (42%), Gaps = 11/132 (8%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARR-RDVDMARILVDYG 121
G PL LA G + +E++ E L +TA H A + +D+ + L+D
Sbjct: 270 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQN 329
Query: 122 AV-VDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIAD-------NEDRTPMHLA 171
+ ++ G T LH A G LV++ G N D +++T + A
Sbjct: 330 VININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWA 389
Query: 172 AENGHAAIIELL 183
E GH AI+ LL
Sbjct: 390 YEKGHDAIVTLL 401
Score = 33.5 bits (73), Expect = 8.3
Identities = 20/66 (30%), Positives = 34/66 (51%), Gaps = 1/66 (1%)
Query: 166 TPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
T +HLA +A +I L A I + G T +HIA++ GH + A +L + G ++
Sbjct: 103 TALHLAVYKDNAELITSLLHS-GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVN 161
Query: 226 MPNKYF 231
+ + F
Sbjct: 162 IQDAVF 167
>AF116826-1|AAD29632.1| 835|Homo sapiens putative protein-tyrosine
kinase protein.
Length = 835
Score = 107 bits (256), Expect = 6e-22
Identities = 100/339 (29%), Positives = 146/339 (43%), Gaps = 34/339 (10%)
Query: 1093 TKDGNTCAHIAAIQGSVKV-IEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
T++G + H+ I G K I LM G+ +R N T L LA +A+++ L
Sbjct: 64 TENGLSLLHLCCICGGKKSHIRTLML---KGLRPSRLTRNGFTALHLAVYKDNAELITSL 120
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQA 1211
+ +GA GLTA+H+A GH DV+ + TPLHIAAYYG
Sbjct: 121 LHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE 180
Query: 1212 ETVRELLS-----HVPGTVKSE-----APTGVSLVPVLGAESGL------------TPLH 1249
+ R LL +V G V + G + L E G PLH
Sbjct: 181 QVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLH 240
Query: 1250 LAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSA-ELLHS 1308
+ G+ ++V+ LL S N G PLHLAC+ G + ++ S E L
Sbjct: 241 FCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTK 300
Query: 1309 TDRHGKTGLHIASTHGH-YQMVEVLLGQGA-EINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
+ +T H A T+G +V+ LL Q IN ++G T LH A GH+ +V+ L
Sbjct: 301 ENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLL 360
Query: 1367 ESGASPKSETNL-NCAPIWFAASENHNDVLEYLLHKEHD 1404
++GA + NL C P + ++ L + K HD
Sbjct: 361 DNGA----DMNLVACDPSRSSGEKDEQTCLMWAYEKGHD 395
Score = 106 bits (255), Expect = 7e-22
Identities = 92/346 (26%), Positives = 156/346 (45%), Gaps = 28/346 (8%)
Query: 1033 LHLAA-ASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
LHL G+ + L+ G G +H A + +E++ L + +
Sbjct: 71 LHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGAD-IQQ 129
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
G T HIA I G ++ + L++ ++ ++ + TPL +AA GH V R+L
Sbjct: 130 VGYGGLTALHIATIAGHLEAADVLLQHGAN--VNIQDAVF-FTPLHIAAYYGHEQVTRLL 186
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDV-MRSTNTLRISSK-KLGLTPLHIAAYYG 1209
++ GA G +HLA+ G N+ + M + ++++ PLH + +G
Sbjct: 187 LKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFG 246
Query: 1210 QAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGV 1269
+ V+ LL +S+ +V + G TPLHLA YNG V + ++ +G
Sbjct: 247 HHDIVKYLL-------QSDLEVQPHVVNIYGD----TPLHLACYNGKFEVAKEIIQISGT 295
Query: 1270 QADAASNENGYNPLHLAC-FGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQM 1328
++ N H AC +G + +V LL ++ ++ R G TGLH A HGH ++
Sbjct: 296 ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL 355
Query: 1329 VEVLLGQGAEIN---------ATDKNGWTPLHCAAKAGHLNVVKLL 1365
V+ LL GA++N + +K+ T L A + GH +V LL
Sbjct: 356 VQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
Score = 100 bits (239), Expect = 6e-20
Identities = 59/167 (35%), Positives = 89/167 (53%), Gaps = 7/167 (4%)
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS-NENGYNPLHLACFGGHMSIVGLLLSR 1301
+G T LHLA Y N ++ LL+S AD G LH+A GH+ +LL
Sbjct: 100 NGFTALHLAVYKDNAELITSLLHSG---ADIQQVGYGGLTALHIATIAGHLEAADVLLQH 156
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNV 1361
A + + D T LHIA+ +GH Q+ +LL GA++N + + G PLH A+ G LN+
Sbjct: 157 GANV-NIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNI 215
Query: 1362 VKLLCESG--ASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQ 1406
KLL E G A ++ N + P+ F + H+D+++YLL + + Q
Sbjct: 216 AKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQ 262
Score = 90.2 bits (214), Expect = 7e-17
Identities = 96/368 (26%), Positives = 160/368 (43%), Gaps = 33/368 (8%)
Query: 833 ESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHET 892
E+ S ++ E+G S LH C I + ++ L+ G S TR N T
Sbjct: 53 EAFSKVNLNYRTENGLSLLHLCC--------ICGGKKSHIRTLMLKGLRPSRLTR-NGFT 103
Query: 893 AFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
A H N +++T ++ H S AD+ + G T L IA GH++ + LL +
Sbjct: 104 ALHLAVYKDNAELITSLL-H-SGADIQQV----GYGGLTALHIATIAGHLEAADVLLQHG 157
Query: 953 ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVK 1012
A V++ D + LH+AA +G+ QV LL A +N G LHLA+ G+ ++ K
Sbjct: 158 ANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAK 217
Query: 1013 FLIRD-HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID--ATDELGQKPIHAA 1069
L+ + A ++ + PLH + G ++ K LL+ + + G P+H A
Sbjct: 218 LLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLA 277
Query: 1070 AQNNYSEVVQLFLQ-QHPNLVMATTKDGNTCAHIAAIQG-SVKVIEELMKFDRTGVISAR 1127
N EV + +Q + T H A G S+ +++ L+ VI+
Sbjct: 278 CYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLD---QNVININ 334
Query: 1128 NKLNDS-TPLQLAAEGGHADVVRVLVRAGA-----SCTDENRAG----LTAVHLAAEHGH 1177
++ D T L A GH +V+ L+ GA +C +G T + A E GH
Sbjct: 335 HQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH 394
Query: 1178 TNVLDVMR 1185
++ +++
Sbjct: 395 DAIVTLLK 402
Score = 84.6 bits (200), Expect = 3e-15
Identities = 86/296 (29%), Positives = 137/296 (46%), Gaps = 27/296 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H A + +I +LL G + TALHIA + + LL +GA+
Sbjct: 100 NGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGAN 159
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V+I+ TPLHIAA ++ +LLK GA N + E G P+H+A+ G L
Sbjct: 160 VNIQDA-VFFTPLHIAAYY-GHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAK 217
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LL+E+G K V D PL R DIV++L++ D + +
Sbjct: 218 LLMEEGS----KADVNAQD-NEDHVPLHFCSRFGHHDIVKYLLQ--SDLEVQP------H 264
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
V+ G + LH AC K EV +++++ +G + + ETAFH G
Sbjct: 265 VVNIYGDTPLHLACYNGKFEVA-----KEIIQI---SGTESLTKENIFSETAFHSACTYG 316
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
+ +++ + +V +N Q G T L AC+ GH++LV LL N A +++
Sbjct: 317 KS---IDLVKFLLDQNVIN-INHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368
Score = 83.8 bits (198), Expect = 6e-15
Identities = 109/396 (27%), Positives = 173/396 (43%), Gaps = 42/396 (10%)
Query: 606 GNPTPVPTELLPIIWKP-ISKDSFYTLN-IDTAMELKSG-FFEDRMIFW-DTFFEK---- 657
GN PT+ WK +S+ T+ ++ +++K E R IF D F K
Sbjct: 2 GNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLN 61
Query: 658 YKHFDGARSIHTAARYG-HVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLL 716
Y+ +G +H G I TL+ KG T + +TALH+AV ++ +LL
Sbjct: 62 YRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL 121
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
GAD+ + G T LHIA I + A +LL+ GA N TP+H+AA +G+
Sbjct: 122 HSGADIQ-QVGYGGLTALHIAT-IAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 179
Query: 777 LATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVS 836
LLL+ G D +V G+ PL +A +I + L+E +G S
Sbjct: 180 EQVTRLLLKFGADVNVSGEV-------GDRPLHLASAKGFLNIAKLLME-----EG---S 224
Query: 837 TAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNH-ETAFH 895
A ++A D + LH+ + +VK L+++ +V + + +T H
Sbjct: 225 KADVNAQDNEDHVPLHFCSRF---------GHHDIVKYLLQSDLEVQPHVVNIYGDTPLH 275
Query: 896 YCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRG-HMQLVNTLL-TNHA 953
G +V E+I T +L ++N T AC G + LV LL N
Sbjct: 276 LACYNGKFEVAKEIIQISGT----ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVI 331
Query: 954 RVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
++ +G + LH A HG++++ LL N A +N
Sbjct: 332 NINHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN 367
Score = 83.0 bits (196), Expect = 1e-14
Identities = 56/189 (29%), Positives = 92/189 (48%), Gaps = 5/189 (2%)
Query: 1242 ESGLTPLHLAAY-NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLS 1300
E+GL+ LHL G ++ +R L+ G++ + NG+ LHLA + + ++ LL
Sbjct: 65 ENGLSLLHLCCICGGKKSHIRTLMLK-GLRPSRLTR-NGFTALHLAVYKDNAELITSLLH 122
Query: 1301 RSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
A++ G T LHIA+ GH + +VLL GA +N D +TPLH AA GH
Sbjct: 123 SGADI-QQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQ 181
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMV 1420
V +LL + GA + P+ A+++ ++ + L+ + D L
Sbjct: 182 VTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHF 241
Query: 1421 CSK-NHNNI 1428
CS+ H++I
Sbjct: 242 CSRFGHHDI 250
Score = 68.1 bits (159), Expect = 3e-10
Identities = 79/302 (26%), Positives = 141/302 (46%), Gaps = 35/302 (11%)
Query: 661 FDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
+ G ++H A GH+ + LLQ G +V++ +T LHIA V LL +GA
Sbjct: 132 YGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA 191
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSG--AGPNKATEDGMTPVHVAAKFGNLA 778
DV++ G+ + PLH+A+ A +L++ G A N + P+H ++FG+
Sbjct: 192 DVNV-SGEVGDRPLHLAS-AKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHD 249
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LL+ + ++ V IY G+TPL +AC + ++ + +I+ ES++
Sbjct: 250 IVKYLLQSDLE-VQPHVVNIY----GDTPLHLACYNGKFEVAKEIIQI---SGTESLTKE 301
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLI-ENGADVSLQTRHNHETAFHYC 897
I + +A H AC K +VK L+ +N +++ Q R H T H
Sbjct: 302 NIFS-----ETAFHSACTYGK--------SIDLVKFLLDQNVININHQGRDGH-TGLHSA 347
Query: 898 AIAGNNDVMTEMI-----AHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
G+ ++ ++ ++ D SR+ ++ T L+ A +GH +V TLL ++
Sbjct: 348 CYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDE--QTCLMWAYEKGHDAIV-TLLKHY 404
Query: 953 AR 954
R
Sbjct: 405 KR 406
Score = 67.3 bits (157), Expect = 6e-10
Identities = 56/195 (28%), Positives = 83/195 (42%), Gaps = 4/195 (2%)
Query: 28 QKDLQRLELSFIELNKERAKQKEWKKLIRDLVFQRGKVPL-LLAVEAGNQSMVRELLSAQ 86
+ DLQ E EL + + K+ + + G L L + G +S +R L+
Sbjct: 32 EDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKG 91
Query: 87 TAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPL 146
T G TALHLA + + ++ L+ GA + G T LHIA G
Sbjct: 92 LRPS--RLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEA 149
Query: 147 VKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIAS 206
AN I D TP+H+AA GH + LL KF A + + G +H+AS
Sbjct: 150 ADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLL-KFGADVNVSGEVGDRPLHLAS 208
Query: 207 LNGHADCAMMLFKKG 221
G + A +L ++G
Sbjct: 209 AKGFLNIAKLLMEEG 223
Score = 66.9 bits (156), Expect = 7e-10
Identities = 49/173 (28%), Positives = 79/173 (45%), Gaps = 5/173 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G L LAV N ++ LL + ++ G TALH+A ++ A +L+ +
Sbjct: 99 RNGFTALHLAVYKDNAELITSLL--HSGADIQQVGYGGLTALHIATIAGHLEAADVLLQH 156
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+ + TPLHIAA G E + + A+ ++ P+HLA+ G I
Sbjct: 157 GANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIA 216
Query: 181 ELLADK-FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG--VYLHMPNKY 230
+LL ++ KA + + + +H S GH D L + V H+ N Y
Sbjct: 217 KLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY 269
Score = 48.4 bits (110), Expect = 3e-04
Identities = 39/169 (23%), Positives = 67/169 (39%), Gaps = 5/169 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL LA G ++ + L+ + + A LH +R D+ + L+
Sbjct: 200 GDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDL 259
Query: 123 VVD--ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE--DRTPMHLAAENGHAA 178
V N G TPLH+A G + K + ++ T H A G +
Sbjct: 260 EVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSI 319
Query: 179 -IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHM 226
+++ L D+ +I + +DG T +H A +GH L G +++
Sbjct: 320 DLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368
Score = 44.8 bits (101), Expect = 0.003
Identities = 36/132 (27%), Positives = 56/132 (42%), Gaps = 11/132 (8%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARR-RDVDMARILVDYG 121
G PL LA G + +E++ E L +TA H A + +D+ + L+D
Sbjct: 270 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQN 329
Query: 122 AV-VDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIAD-------NEDRTPMHLA 171
+ ++ G T LH A G LV++ G N D +++T + A
Sbjct: 330 VININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWA 389
Query: 172 AENGHAAIIELL 183
E GH AI+ LL
Sbjct: 390 YEKGHDAIVTLL 401
Score = 33.5 bits (73), Expect = 8.3
Identities = 20/66 (30%), Positives = 34/66 (51%), Gaps = 1/66 (1%)
Query: 166 TPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
T +HLA +A +I L A I + G T +HIA++ GH + A +L + G ++
Sbjct: 103 TALHLAVYKDNAELITSLLHS-GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVN 161
Query: 226 MPNKYF 231
+ + F
Sbjct: 162 IQDAVF 167
>AB208941-1|BAD92178.1| 941|Homo sapiens TNNI3 interacting kinase
variant protein.
Length = 941
Score = 107 bits (256), Expect = 6e-22
Identities = 100/339 (29%), Positives = 146/339 (43%), Gaps = 34/339 (10%)
Query: 1093 TKDGNTCAHIAAIQGSVKV-IEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
T++G + H+ I G K I LM G+ +R N T L LA +A+++ L
Sbjct: 170 TENGLSLLHLCCICGGKKSHIRTLML---KGLRPSRLTRNGFTALHLAVYKDNAELITSL 226
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQA 1211
+ +GA GLTA+H+A GH DV+ + TPLHIAAYYG
Sbjct: 227 LHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE 286
Query: 1212 ETVRELLS-----HVPGTVKSE-----APTGVSLVPVLGAESGL------------TPLH 1249
+ R LL +V G V + G + L E G PLH
Sbjct: 287 QVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLH 346
Query: 1250 LAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSA-ELLHS 1308
+ G+ ++V+ LL S N G PLHLAC+ G + ++ S E L
Sbjct: 347 FCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTK 406
Query: 1309 TDRHGKTGLHIASTHGH-YQMVEVLLGQGA-EINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
+ +T H A T+G +V+ LL Q IN ++G T LH A GH+ +V+ L
Sbjct: 407 ENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLL 466
Query: 1367 ESGASPKSETNL-NCAPIWFAASENHNDVLEYLLHKEHD 1404
++GA + NL C P + ++ L + K HD
Sbjct: 467 DNGA----DMNLVACDPSRSSGEKDEQTCLMWAYEKGHD 501
Score = 106 bits (255), Expect = 7e-22
Identities = 92/346 (26%), Positives = 156/346 (45%), Gaps = 28/346 (8%)
Query: 1033 LHLAA-ASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
LHL G+ + L+ G G +H A + +E++ L + +
Sbjct: 177 LHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGAD-IQQ 235
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
G T HIA I G ++ + L++ ++ ++ + TPL +AA GH V R+L
Sbjct: 236 VGYGGLTALHIATIAGHLEAADVLLQHGAN--VNIQDAVF-FTPLHIAAYYGHEQVTRLL 292
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDV-MRSTNTLRISSK-KLGLTPLHIAAYYG 1209
++ GA G +HLA+ G N+ + M + ++++ PLH + +G
Sbjct: 293 LKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFG 352
Query: 1210 QAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGV 1269
+ V+ LL +S+ +V + G TPLHLA YNG V + ++ +G
Sbjct: 353 HHDIVKYLL-------QSDLEVQPHVVNIYGD----TPLHLACYNGKFEVAKEIIQISGT 401
Query: 1270 QADAASNENGYNPLHLAC-FGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQM 1328
++ N H AC +G + +V LL ++ ++ R G TGLH A HGH ++
Sbjct: 402 ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL 461
Query: 1329 VEVLLGQGAEIN---------ATDKNGWTPLHCAAKAGHLNVVKLL 1365
V+ LL GA++N + +K+ T L A + GH +V LL
Sbjct: 462 VQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 507
Score = 100 bits (239), Expect = 6e-20
Identities = 59/167 (35%), Positives = 89/167 (53%), Gaps = 7/167 (4%)
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS-NENGYNPLHLACFGGHMSIVGLLLSR 1301
+G T LHLA Y N ++ LL+S AD G LH+A GH+ +LL
Sbjct: 206 NGFTALHLAVYKDNAELITSLLHSG---ADIQQVGYGGLTALHIATIAGHLEAADVLLQH 262
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNV 1361
A + + D T LHIA+ +GH Q+ +LL GA++N + + G PLH A+ G LN+
Sbjct: 263 GANV-NIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNI 321
Query: 1362 VKLLCESG--ASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQ 1406
KLL E G A ++ N + P+ F + H+D+++YLL + + Q
Sbjct: 322 AKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQ 368
Score = 90.2 bits (214), Expect = 7e-17
Identities = 96/368 (26%), Positives = 160/368 (43%), Gaps = 33/368 (8%)
Query: 833 ESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHET 892
E+ S ++ E+G S LH C I + ++ L+ G S TR N T
Sbjct: 159 EAFSKVNLNYRTENGLSLLHLCC--------ICGGKKSHIRTLMLKGLRPSRLTR-NGFT 209
Query: 893 AFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
A H N +++T ++ H S AD+ + G T L IA GH++ + LL +
Sbjct: 210 ALHLAVYKDNAELITSLL-H-SGADIQQV----GYGGLTALHIATIAGHLEAADVLLQHG 263
Query: 953 ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVK 1012
A V++ D + LH+AA +G+ QV LL A +N G LHLA+ G+ ++ K
Sbjct: 264 ANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAK 323
Query: 1013 FLIRD-HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID--ATDELGQKPIHAA 1069
L+ + A ++ + PLH + G ++ K LL+ + + G P+H A
Sbjct: 324 LLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLA 383
Query: 1070 AQNNYSEVVQLFLQ-QHPNLVMATTKDGNTCAHIAAIQG-SVKVIEELMKFDRTGVISAR 1127
N EV + +Q + T H A G S+ +++ L+ VI+
Sbjct: 384 CYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLD---QNVININ 440
Query: 1128 NKLNDS-TPLQLAAEGGHADVVRVLVRAGA-----SCTDENRAG----LTAVHLAAEHGH 1177
++ D T L A GH +V+ L+ GA +C +G T + A E GH
Sbjct: 441 HQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH 500
Query: 1178 TNVLDVMR 1185
++ +++
Sbjct: 501 DAIVTLLK 508
Score = 84.6 bits (200), Expect = 3e-15
Identities = 86/296 (29%), Positives = 137/296 (46%), Gaps = 27/296 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H A + +I +LL G + TALHIA + + LL +GA+
Sbjct: 206 NGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGAN 265
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V+I+ TPLHIAA ++ +LLK GA N + E G P+H+A+ G L
Sbjct: 266 VNIQDA-VFFTPLHIAAYY-GHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAK 323
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LL+E+G K V D PL R DIV++L++ D + +
Sbjct: 324 LLMEEGS----KADVNAQD-NEDHVPLHFCSRFGHHDIVKYLLQ--SDLEVQP------H 370
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
V+ G + LH AC K EV +++++ +G + + ETAFH G
Sbjct: 371 VVNIYGDTPLHLACYNGKFEVA-----KEIIQI---SGTESLTKENIFSETAFHSACTYG 422
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
+ +++ + +V +N Q G T L AC+ GH++LV LL N A +++
Sbjct: 423 KS---IDLVKFLLDQNVIN-INHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 474
Score = 83.0 bits (196), Expect = 1e-14
Identities = 56/189 (29%), Positives = 92/189 (48%), Gaps = 5/189 (2%)
Query: 1242 ESGLTPLHLAAY-NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLS 1300
E+GL+ LHL G ++ +R L+ G++ + NG+ LHLA + + ++ LL
Sbjct: 171 ENGLSLLHLCCICGGKKSHIRTLMLK-GLRPSRLTR-NGFTALHLAVYKDNAELITSLLH 228
Query: 1301 RSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
A++ G T LHIA+ GH + +VLL GA +N D +TPLH AA GH
Sbjct: 229 SGADI-QQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQ 287
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMV 1420
V +LL + GA + P+ A+++ ++ + L+ + D L
Sbjct: 288 VTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHF 347
Query: 1421 CSK-NHNNI 1428
CS+ H++I
Sbjct: 348 CSRFGHHDI 356
Score = 80.6 bits (190), Expect = 6e-14
Identities = 89/314 (28%), Positives = 141/314 (44%), Gaps = 33/314 (10%)
Query: 679 INTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAA 738
I TL+ KG T + +TALH+AV ++ +LL GAD+ + G T LHIA
Sbjct: 190 IRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQ-QVGYGGLTALHIAT 248
Query: 739 RIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCI 798
I + A +LL+ GA N TP+H+AA +G+ LLL+ G D +V
Sbjct: 249 -IAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEV-- 305
Query: 799 YDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVT 858
G+ PL +A +I + L+E +G S A ++A D + LH+ +
Sbjct: 306 -----GDRPLHLASAKGFLNIAKLLME-----EG---SKADVNAQDNEDHVPLHFCSRF- 351
Query: 859 KEEVKIPTADRQVVKCLIENGADVSLQTRHNH-ETAFHYCAIAGNNDVMTEMIAHISTAD 917
+VK L+++ +V + + +T H G +V E+I T
Sbjct: 352 --------GHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGT-- 401
Query: 918 VSRALNRQNSIGWTPLLIACHRG-HMQLVNTLL-TNHARVDVFDVEGRSALHLAAEHGYL 975
+L ++N T AC G + LV LL N ++ +G + LH A HG++
Sbjct: 402 --ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHI 459
Query: 976 QVCDALLTNKAFIN 989
++ LL N A +N
Sbjct: 460 RLVQFLLDNGADMN 473
Score = 68.1 bits (159), Expect = 3e-10
Identities = 79/302 (26%), Positives = 141/302 (46%), Gaps = 35/302 (11%)
Query: 661 FDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
+ G ++H A GH+ + LLQ G +V++ +T LHIA V LL +GA
Sbjct: 238 YGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA 297
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSG--AGPNKATEDGMTPVHVAAKFGNLA 778
DV++ G+ + PLH+A+ A +L++ G A N + P+H ++FG+
Sbjct: 298 DVNV-SGEVGDRPLHLAS-AKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHD 355
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LL+ + ++ V IY G+TPL +AC + ++ + +I+ ES++
Sbjct: 356 IVKYLLQSDLE-VQPHVVNIY----GDTPLHLACYNGKFEVAKEIIQI---SGTESLTKE 407
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLI-ENGADVSLQTRHNHETAFHYC 897
I + +A H AC K +VK L+ +N +++ Q R H T H
Sbjct: 408 NIFS-----ETAFHSACTYGK--------SIDLVKFLLDQNVININHQGRDGH-TGLHSA 453
Query: 898 AIAGNNDVMTEMI-----AHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
G+ ++ ++ ++ D SR+ ++ T L+ A +GH +V TLL ++
Sbjct: 454 CYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDE--QTCLMWAYEKGHDAIV-TLLKHY 510
Query: 953 AR 954
R
Sbjct: 511 KR 512
Score = 67.3 bits (157), Expect = 6e-10
Identities = 56/195 (28%), Positives = 83/195 (42%), Gaps = 4/195 (2%)
Query: 28 QKDLQRLELSFIELNKERAKQKEWKKLIRDLVFQRGKVPL-LLAVEAGNQSMVRELLSAQ 86
+ DLQ E EL + + K+ + + G L L + G +S +R L+
Sbjct: 138 EDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKG 197
Query: 87 TAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPL 146
T G TALHLA + + ++ L+ GA + G T LHIA G
Sbjct: 198 LRPS--RLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEA 255
Query: 147 VKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIAS 206
AN I D TP+H+AA GH + LL KF A + + G +H+AS
Sbjct: 256 ADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLL-KFGADVNVSGEVGDRPLHLAS 314
Query: 207 LNGHADCAMMLFKKG 221
G + A +L ++G
Sbjct: 315 AKGFLNIAKLLMEEG 329
Score = 66.9 bits (156), Expect = 7e-10
Identities = 49/173 (28%), Positives = 79/173 (45%), Gaps = 5/173 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G L LAV N ++ LL + ++ G TALH+A ++ A +L+ +
Sbjct: 205 RNGFTALHLAVYKDNAELITSLL--HSGADIQQVGYGGLTALHIATIAGHLEAADVLLQH 262
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+ + TPLHIAA G E + + A+ ++ P+HLA+ G I
Sbjct: 263 GANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIA 322
Query: 181 ELLADK-FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG--VYLHMPNKY 230
+LL ++ KA + + + +H S GH D L + V H+ N Y
Sbjct: 323 KLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY 375
Score = 48.4 bits (110), Expect = 3e-04
Identities = 39/169 (23%), Positives = 67/169 (39%), Gaps = 5/169 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL LA G ++ + L+ + + A LH +R D+ + L+
Sbjct: 306 GDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDL 365
Query: 123 VVD--ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE--DRTPMHLAAENGHAA 178
V N G TPLH+A G + K + ++ T H A G +
Sbjct: 366 EVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSI 425
Query: 179 -IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHM 226
+++ L D+ +I + +DG T +H A +GH L G +++
Sbjct: 426 DLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 474
Score = 44.8 bits (101), Expect = 0.003
Identities = 36/132 (27%), Positives = 56/132 (42%), Gaps = 11/132 (8%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARR-RDVDMARILVDYG 121
G PL LA G + +E++ E L +TA H A + +D+ + L+D
Sbjct: 376 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQN 435
Query: 122 AV-VDATNGAGQTPLHIAAAEGDEPLVKYFY--GVRANAAIAD-------NEDRTPMHLA 171
+ ++ G T LH A G LV++ G N D +++T + A
Sbjct: 436 VININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWA 495
Query: 172 AENGHAAIIELL 183
E GH AI+ LL
Sbjct: 496 YEKGHDAIVTLL 507
Score = 33.5 bits (73), Expect = 8.3
Identities = 20/66 (30%), Positives = 34/66 (51%), Gaps = 1/66 (1%)
Query: 166 TPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
T +HLA +A +I L A I + G T +HIA++ GH + A +L + G ++
Sbjct: 209 TALHLAVYKDNAELITSLLHS-GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVN 267
Query: 226 MPNKYF 231
+ + F
Sbjct: 268 IQDAVF 273
>AF159164-1|AAD45345.1| 544|Homo sapiens ankyrin repeat-containing
protein ASB-2 protein.
Length = 544
Score = 106 bits (255), Expect = 7e-22
Identities = 93/356 (26%), Positives = 167/356 (46%), Gaps = 30/356 (8%)
Query: 993 RNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELG 1052
+ G LH AA G +K L R + ID TL+++T ++LA G ++ LL+ G
Sbjct: 47 KEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAG 106
Query: 1053 ANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVI 1112
A D +++ + P++ A + +E V++ +Q + + + G T H + + ++V+
Sbjct: 107 AEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNR-GWTALHESVSRNDLEVM 165
Query: 1113 EELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA 1172
+ L+ +G +K TPL +AA+ G + +R L + GA + +A++ A
Sbjct: 166 QILV----SGGAKVESKNAYGTPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEA 221
Query: 1173 AEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
++ H V++ + S + K GL PLHIA+ G V+ LL P T ++
Sbjct: 222 CKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLL---PVTSRTRI--- 275
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSA-GVQADAAS------NENGYNPLHL 1285
SG++PLHLAA ++ V+ LL++ V A + + L+
Sbjct: 276 --------RRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYF 327
Query: 1286 ACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINA 1341
A ++ LLL A+ +R + L +A HG + +++LL GA I+A
Sbjct: 328 AVVNNNVYATELLLQHGAD----PNRDVISPLLVAIRHGCLRTMQLLLDHGANIDA 379
Score = 101 bits (242), Expect = 3e-20
Identities = 83/309 (26%), Positives = 143/309 (46%), Gaps = 21/309 (6%)
Query: 1032 PLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
PL A G E K +++ G N+ ++ G P+H AA +++ + +P +
Sbjct: 19 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 78
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
T T ++A +G + + L++ IS +++ TPL A E +A+ V++L
Sbjct: 79 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSR---ETPLYKACERKNAEAVKIL 135
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQA 1211
V+ A G TA+H + V+ ++ S ++ SK TPL +AA GQ
Sbjct: 136 VQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGA-KVESKNAYGTPLFVAAQSGQL 194
Query: 1212 ETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQA 1271
E +R L+ + ++A S L+ A N +E VV LL S G A
Sbjct: 195 EALR-FLAKYGADINTQASDNAS------------ALYEACKNEHEEVVEFLL-SQGADA 240
Query: 1272 DAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEV 1331
+ +N++G PLH+A G+ IV +LL ++ R G + LH+A+ H +++E
Sbjct: 241 N-KTNKDGLLPLHIASKKGNYRIVQMLLPVTSRT--RIRRSGVSPLHLAAERNHDEVLEA 297
Query: 1332 LLGQGAEIN 1340
LL ++N
Sbjct: 298 LLSARFDVN 306
Score = 91.9 bits (218), Expect = 2e-17
Identities = 80/281 (28%), Positives = 129/281 (45%), Gaps = 21/281 (7%)
Query: 1135 PLQLAAEGGHADVVRVLVRAGASCTDENRAGL-TAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
PL AA G ++VL RA D+ TAV+LA GH + L +
Sbjct: 52 PLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDI 111
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAY 1253
S K TPL+ A AE V+ L+ H T G T LH +
Sbjct: 112 SNKSRETPLYKACERKNAEAVKILVQHNADTNHR-------------CNRGWTALHESVS 158
Query: 1254 NGNENVVRLLLNSAGVQADAASNENGYN-PLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
+ V+++L+ S G + ++ +N Y PL +A G + + L A++ ++
Sbjct: 159 RNDLEVMQILV-SGGAKVES---KNAYGTPLFVAAQSGQLEALRFLAKYGADI-NTQASD 213
Query: 1313 GKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASP 1372
+ L+ A + H ++VE LL QGA+ N T+K+G PLH A+K G+ +V++L +
Sbjct: 214 NASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRT 273
Query: 1373 KSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKR 1413
+ + +P+ AA NH++VLE LL D + + +R
Sbjct: 274 RIRRS-GVSPLHLAAERNHDEVLEALLSARFDVNTPLAPER 313
Score = 81.0 bits (191), Expect = 4e-14
Identities = 77/300 (25%), Positives = 139/300 (46%), Gaps = 19/300 (6%)
Query: 891 ETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLT 950
ETA + G+ D + ++ + D+S N TPL AC R + + V L+
Sbjct: 84 ETAVYLATCRGHLDCLLSLLQAGAEPDIS------NKSRETPLYKACERKNAEAVKILVQ 137
Query: 951 NHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHL 1010
++A + G +ALH + L+V L++ A + SK G T L +AA +G
Sbjct: 138 HNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYG-TPLFVAAQSGQLEA 196
Query: 1011 VKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAA 1070
++FL + + A I+ + L+ A + EV + LL GA+ + T++ G P+H A+
Sbjct: 197 LRFLAK-YGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIAS 255
Query: 1071 QNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM--KFD-RTGVISAR 1127
+ +VQ+ L + G + H+AA + +V+E L+ +FD T + R
Sbjct: 256 KKGNYRIVQMLLPVTSR--TRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPER 313
Query: 1128 NKLND---STPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+L + S+ L A + +L++ GA D NR ++ + +A HG + ++
Sbjct: 314 ARLYEDRRSSALYFAVVNNNVYATELLLQHGA---DPNRDVISPLLVAIRHGCLRTMQLL 370
Score = 74.9 bits (176), Expect = 3e-12
Identities = 101/405 (24%), Positives = 173/405 (42%), Gaps = 53/405 (13%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGE-SVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
+G +H AA YG VG + L + ++D T TA+++A + +LL GA
Sbjct: 48 EGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGA 107
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
+ I K RETPL+ A + + + L++ A N G T +H + +L +
Sbjct: 108 EPDI-SNKSRETPLYKACERKNAEAVKI-LVQHNADTNHRCNRGWTALHESVSRNDLEVM 165
Query: 781 VLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFI 840
+L+ G K TPL +A +S + +R L ++ D I
Sbjct: 166 QILVSGGAKVESKNAY--------GTPLFVAAQSGQLEALRFLAKYGAD----------I 207
Query: 841 DAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIA 900
+ D ASAL+ ACK EE VV+ L+ GAD + +T + H +
Sbjct: 208 NTQASDNASALYEACKNEHEE---------VVEFLLSQGADAN-KTNKDGLLPLHIASKK 257
Query: 901 GNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH-------- 952
GN ++ ++ S + R+ G +PL +A R H +++ LL+
Sbjct: 258 GNYRIVQMLLPVTSRTRIRRS-------GVSPLHLAAERNHDEVLEALLSARFDVNTPLA 310
Query: 953 -ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLV 1011
R +++ SAL+ A + + + LL + A N R+ + L +A +G +
Sbjct: 311 PERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTM 367
Query: 1012 KFLIRDHNAMID--VLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
+ L+ DH A ID + T P + A + + K L++LG +
Sbjct: 368 QLLL-DHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCD 411
Score = 66.9 bits (156), Expect = 7e-10
Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 8/163 (4%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D+ + + PL A E N V+ L+ + G TALH + R D+++ +I
Sbjct: 110 DISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNR--GWTALHESVSRNDLEVMQI 167
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYF--YGVRANAAIADNEDRTPMHLAAEN 174
LV GA V++ N G TPL +AA G +++ YG N +DN + ++ A +N
Sbjct: 168 LVSGGAKVESKNAYG-TPLFVAAQSGQLEALRFLAKYGADINTQASDN--ASALYEACKN 224
Query: 175 GHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
H ++E L + A + KDG +HIAS G+ ML
Sbjct: 225 EHEEVVEFLLSQ-GADANKTNKDGLLPLHIASKKGNYRIVQML 266
Score = 57.6 bits (133), Expect = 4e-07
Identities = 37/153 (24%), Positives = 72/153 (47%), Gaps = 2/153 (1%)
Query: 1247 PLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELL 1306
PL A +G+E ++ ++ A+ N+ G+ PLH A + G + + +L +
Sbjct: 19 PLIKAIKDGDEEALKTMIKEGKNLAEP--NKEGWLPLHEAAYYGQVGCLKVLQRAYPGTI 76
Query: 1307 HSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
+T +++A+ GH + LL GAE + ++K+ TPL+ A + + VK+L
Sbjct: 77 DQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILV 136
Query: 1367 ESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+ A N + + S N +V++ L+
Sbjct: 137 QHNADTNHRCNRGWTALHESVSRNDLEVMQILV 169
Score = 55.6 bits (128), Expect = 2e-06
Identities = 36/123 (29%), Positives = 61/123 (49%), Gaps = 4/123 (3%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL +A ++G +R L A+ + +AL+ A + ++ L+ GA +
Sbjct: 184 PLFVAAQSGQLEALRFL--AKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADAN 241
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE-LLA 184
TN G PLHIA+ +G+ +V+ V + I +P+HLAAE H ++E LL+
Sbjct: 242 KTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR-RSGVSPLHLAAERNHDEVLEALLS 300
Query: 185 DKF 187
+F
Sbjct: 301 ARF 303
Score = 52.8 bits (121), Expect = 1e-05
Identities = 29/96 (30%), Positives = 46/96 (47%)
Query: 134 PLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFE 193
PL A +GDE +K N A + E P+H AA G +++L + +I +
Sbjct: 19 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 78
Query: 194 RTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
RT T +++A+ GH DC + L + G + NK
Sbjct: 79 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNK 114
Score = 39.9 bits (89), Expect = 0.096
Identities = 38/161 (23%), Positives = 67/161 (41%), Gaps = 3/161 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G +PL A G ++ L A + T +TA++LA R +D L+
Sbjct: 47 KEGWLPLHEAAYYGQVGCLKVLQRAYPGT-IDQRTLQEETAVYLATCRGHLDCLLSLLQA 105
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA D +N + +TPL+ A + VK A+ N T +H + ++
Sbjct: 106 GAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVM 165
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
++L A + + G+ L +A+ +G + L K G
Sbjct: 166 QILVSG-GAKVESKNAYGTPLF-VAAQSGQLEALRFLAKYG 204
>EF041819-1|ABL09300.1| 782|Homo sapiens several ankyrin repeat
protein transcript variant 2 protein.
Length = 782
Score = 106 bits (254), Expect = 1e-21
Identities = 91/338 (26%), Positives = 151/338 (44%), Gaps = 19/338 (5%)
Query: 1033 LHLAAASGQIEVCKLLLELGANIDATDELGQ-KPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
+H A +G ++ ++ GA+I+ D L + P+H AA + E + L ++
Sbjct: 295 IHDAVRAGDVKQLSEIVVRGASINELDVLHKFTPLHWAAHSGSLECLHWLLWHGADITHV 354
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
TT+ G T +HIAAI+G ++ L+ G TPL LAA GH+ ++++
Sbjct: 355 TTR-GWTASHIAAIRGQDACVQALIM---NGANLTAQDDRGCTPLHLAATHGHSFTLQIM 410
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQA 1211
+R+G + R VH AA HG L ++ G P+H+AA G
Sbjct: 411 LRSGDPSVTDKREW-RPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHL 469
Query: 1212 ETVRELLSHVPGTVKSEAPTGVSLVPVLGA--ESGLTPLHLAAYNGNENVVRLLLNSAGV 1269
+ L+S + S VL A ++G L LA +N+++ + +
Sbjct: 470 HCFKFLVSRMS-----------SATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYE 518
Query: 1270 QADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMV 1329
D E P H+A F G + ++ L+ ++ +G T +H A+ GH + +
Sbjct: 519 GKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECL 578
Query: 1330 EVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
+ L+ GA+ N T+K G P A + HL VKLL E
Sbjct: 579 QWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEE 616
Score = 86.6 bits (205), Expect = 8e-16
Identities = 76/332 (22%), Positives = 147/332 (44%), Gaps = 12/332 (3%)
Query: 890 HETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLL 949
H + H AG+ ++E++ ++ + L++ +TPL A H G ++ ++ LL
Sbjct: 291 HFGSIHDAVRAGDVKQLSEIVVRGASINELDVLHK-----FTPLHWAAHSGSLECLHWLL 345
Query: 950 TNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAH 1009
+ A + G +A H+AA G AL+ N A + ++ G T LHLAA +G++
Sbjct: 346 WHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSF 405
Query: 1010 LVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA 1069
++ ++R + V ++ P+H AA G++ +LL++ G +I+ D G P+H A
Sbjct: 406 TLQIMLRSGDP--SVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLA 463
Query: 1070 AQNNYSEVVQLFLQQHPN---LVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISA 1126
A + + + + + ++ A +G +A +++ + + G
Sbjct: 464 AMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGK-DL 522
Query: 1127 RNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENR-AGLTAVHLAAEHGHTNVLDVMR 1185
++ + P +AA G +++ LV G +E G T +H AA GH L +
Sbjct: 523 EDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLI 582
Query: 1186 STNTLRISSKKLGLTPLHIAAYYGQAETVREL 1217
+ K G P +A + V+ L
Sbjct: 583 KMGADSNITNKAGERPSDVAKRFAHLAAVKLL 614
Score = 83.4 bits (197), Expect = 8e-15
Identities = 71/241 (29%), Positives = 115/241 (47%), Gaps = 18/241 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
T +AA G V+ L+ GA+ T ++ G T +HLAA HGH+ L +M + ++
Sbjct: 360 TASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGDPSVT 419
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAY 1253
K+ P+H AA++G+ ++ L+ G S+ V +G P+HLAA
Sbjct: 420 DKR-EWRPVHYAAFHGRLGCLQLLVKW-----------GCSIEDV--DYNGNLPVHLAAM 465
Query: 1254 NGNENVVRLLLN--SAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDR 1311
G+ + + L++ S+ Q A N+NG N L LA +I+ + E D+
Sbjct: 466 EGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQ 525
Query: 1312 HGKTGL-HIASTHGHYQMVEVLLGQGA-EINATDKNGWTPLHCAAKAGHLNVVKLLCESG 1369
H+A+ G M++ L+ G IN NG TP+H AA GH+ ++ L + G
Sbjct: 526 ETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMG 585
Query: 1370 A 1370
A
Sbjct: 586 A 586
Score = 79.0 bits (186), Expect = 2e-13
Identities = 50/156 (32%), Positives = 77/156 (49%), Gaps = 4/156 (2%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
TPLH AA++G+ + LL + G+ H+A G + V L+ A L
Sbjct: 327 TPLHWAAHSGSLECLHWLLWHGADITHVTTR--GWTASHIAAIRGQDACVQALIMNGANL 384
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
DR G T LH+A+THGH ++++L G + + TDK W P+H AA G L ++LL
Sbjct: 385 TAQDDR-GCTPLHLAATHGHSFTLQIMLRSG-DPSVTDKREWRPVHYAAFHGRLGCLQLL 442
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
+ G S + P+ AA E H ++L+ +
Sbjct: 443 VKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSR 478
Score = 68.1 bits (159), Expect = 3e-10
Identities = 40/120 (33%), Positives = 57/120 (47%), Gaps = 2/120 (1%)
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
+ PLH A G + + LL A++ H T R G T HIA+ G V+ L+ GA +
Sbjct: 326 FTPLHWAAHSGSLECLHWLLWHGADITHVTTR-GWTASHIAAIRGQDACVQALIMNGANL 384
Query: 1340 NATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
A D G TPLH AA GH ++++ SG P P+ +AA L+ L+
Sbjct: 385 TAQDDRGCTPLHLAATHGHSFTLQIMLRSG-DPSVTDKREWRPVHYAAFHGRLGCLQLLV 443
Score = 63.3 bits (147), Expect = 9e-09
Identities = 68/260 (26%), Positives = 116/260 (44%), Gaps = 24/260 (9%)
Query: 872 VKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWT 931
V+ LI NGA+++ Q T H A G++ + M+ + D S R+ W
Sbjct: 374 VQALIMNGANLTAQDDRGC-TPLHLAATHGHSFTLQIMLR---SGDPSVTDKRE----WR 425
Query: 932 PLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSK 991
P+ A G + + L+ ++ D G +HLAA G+L L++ +
Sbjct: 426 PVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQV 485
Query: 992 AR----NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPL----HLAAASGQIE 1043
+ NG L LA ++++F+ A + L+ Q L H+AA G +
Sbjct: 486 LKAFNDNGENVLDLAQRFFKQNILQFI---QGAEYEGKDLEDQETLAFPGHVAAFKGDLG 542
Query: 1044 VCKLLLELGA-NIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHI 1102
+ K L+E G NI+ + G P+H AA + E +Q ++ + + T K G + +
Sbjct: 543 MLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNI-TNKAGERPSDV 601
Query: 1103 A---AIQGSVKVIEELMKFD 1119
A A +VK++EEL K+D
Sbjct: 602 AKRFAHLAAVKLLEELQKYD 621
Score = 62.1 bits (144), Expect = 2e-08
Identities = 44/155 (28%), Positives = 73/155 (47%), Gaps = 4/155 (2%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL A +G+ + LL + T G TA H+AA R + L+ GA +
Sbjct: 328 PLHWAAHSGSLECLHWLL--WHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLT 385
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
A + G TPLH+AA G ++ + ++ D + P+H AA +G ++LL
Sbjct: 386 AQDDRGCTPLHLAATHGHSFTLQIMLR-SGDPSVTDKREWRPVHYAAFHGRLGCLQLLV- 443
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
K+ SI + +G+ +H+A++ GH C L +
Sbjct: 444 KWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSR 478
Score = 61.7 bits (143), Expect = 3e-08
Identities = 44/127 (34%), Positives = 66/127 (51%), Gaps = 6/127 (4%)
Query: 666 SIHTAARYGHVGIINTLLQKGESV-DVTTNDNYTALHIAVESCKPAVVETLLGYGADV-H 723
SIH A R G V ++ ++ +G S+ ++ +T LH A S + LL +GAD+ H
Sbjct: 294 SIHDAVRAGDVKQLSEIVVRGASINELDVLHKFTPLHWAAHSGSLECLHWLLWHGADITH 353
Query: 724 IRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLL 783
+ + T HIAA I D C L+ +GA + G TP+H+AA G+ TL ++
Sbjct: 354 VT--TRGWTASHIAA-IRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIM 410
Query: 784 LEDGGDP 790
L GDP
Sbjct: 411 LR-SGDP 416
Score = 57.6 bits (133), Expect = 4e-07
Identities = 34/120 (28%), Positives = 56/120 (46%)
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
+ +H A G + + ++ R A + H T LH A+ G + + LL GA+I
Sbjct: 292 FGSIHDAVRAGDVKQLSEIVVRGASINELDVLHKFTPLHWAAHSGSLECLHWLLWHGADI 351
Query: 1340 NATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
GWT H AA G V+ L +GA+ ++ + C P+ AA+ H+ L+ +L
Sbjct: 352 THVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIML 411
Score = 57.6 bits (133), Expect = 4e-07
Identities = 35/122 (28%), Positives = 58/122 (47%), Gaps = 2/122 (1%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T LH AA ++ L+ +GA + G T HIAA G + V+ AN
Sbjct: 327 TPLHWAAHSGSLECLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTA 386
Query: 160 ADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
D+ TP+HLAA +GH+ ++++ S+ ++ + +H A+ +G C +L K
Sbjct: 387 QDDRGCTPLHLAATHGHSFTLQIMLRSGDPSVTDKRE--WRPVHYAAFHGRLGCLQLLVK 444
Query: 220 KG 221
G
Sbjct: 445 WG 446
Score = 53.6 bits (123), Expect = 7e-06
Identities = 38/142 (26%), Positives = 67/142 (47%), Gaps = 6/142 (4%)
Query: 98 GDTALHLAARRRDVDMARILVDYGA----VVDATNGAGQTPLHIAAAEGDEPLVKYFYGV 153
G+ +HLAA + + LV + V+ A N G+ L +A + ++++ G
Sbjct: 456 GNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGA 515
Query: 154 RANAAIADNEDRT--PMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHA 211
++++ P H+AA G +++ L + +I ER +GST MH A+ GH
Sbjct: 516 EYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHI 575
Query: 212 DCAMMLFKKGVYLHMPNKYFEK 233
+C L K G ++ NK E+
Sbjct: 576 ECLQWLIKMGADSNITNKAGER 597
Score = 43.2 bits (97), Expect = 0.010
Identities = 25/90 (27%), Positives = 46/90 (51%), Gaps = 1/90 (1%)
Query: 103 HLAARRRDVDMARILVDYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIAD 161
H+AA + D+ M + LV+ G + ++ G TP+H AA +G +++ + A++ I +
Sbjct: 533 HVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITN 592
Query: 162 NEDRTPMHLAAENGHAAIIELLADKFKASI 191
P +A H A ++LL + K I
Sbjct: 593 KAGERPSDVAKRFAHLAAVKLLEELQKYDI 622
Score = 37.9 bits (84), Expect = 0.39
Identities = 31/115 (26%), Positives = 49/115 (42%), Gaps = 3/115 (2%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G + H AA G + L+ G ++ + T LH+A ++ +L G D
Sbjct: 358 GWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSG-DP 416
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
+ K+ P+H AA C +L+K G +G PVH+AA G+L
Sbjct: 417 SVTD-KREWRPVHYAA-FHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHL 469
Score = 37.5 bits (83), Expect = 0.51
Identities = 35/136 (25%), Positives = 61/136 (44%), Gaps = 9/136 (6%)
Query: 661 FDGARSIHTAARYGHVGIINTLLQKGESVDVTT---NDN-YTALHIAVESCKPAVVETLL 716
++G +H AA GH+ L+ + S NDN L +A K +++ +
Sbjct: 454 YNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFI- 512
Query: 717 GYGADVHIRGGKQRET---PLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAK 773
GA+ + + +ET P H+AA D ++ N+ ++G TP+H AA
Sbjct: 513 -QGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAG 571
Query: 774 FGNLATLVLLLEDGGD 789
G++ L L++ G D
Sbjct: 572 QGHIECLQWLIKMGAD 587
Score = 35.5 bits (78), Expect = 2.1
Identities = 33/132 (25%), Positives = 50/132 (37%), Gaps = 3/132 (2%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V RG +A G + V+ L+ L A G T LHLAA +I++
Sbjct: 354 VTTRGWTASHIAAIRGQDACVQALI--MNGANLTAQDDRGCTPLHLAATHGHSFTLQIML 411
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
G T+ P+H AA G ++ + D P+HLAA GH
Sbjct: 412 RSGDP-SVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLH 470
Query: 179 IIELLADKFKAS 190
+ L + ++
Sbjct: 471 CFKFLVSRMSSA 482
>BC130610-1|AAI30611.1| 1672|Homo sapiens KIDINS220 protein protein.
Length = 1672
Score = 106 bits (254), Expect = 1e-21
Identities = 95/353 (26%), Positives = 166/353 (47%), Gaps = 13/353 (3%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
++VK LI+NGA+ +L+ N TA + G+ ++ E++ V+ L ++ G
Sbjct: 10 EIVKELIKNGANCNLEDLDNW-TALISASKEGHVHIVEELLK----CGVN--LEHRDMGG 62
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
WT L+ AC++G +V LL++ A V + + AA G+ + LL N A +N
Sbjct: 63 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN 122
Query: 990 SKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL 1049
+ G T L AA G+ VK L+ A +D T L +A G + K +L
Sbjct: 123 CSDKYGTTPLVWAARKGHLECVKHLLA-MGADVDQEGANSMTALIVAVKGGYTQSVKEIL 181
Query: 1050 ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSV 1109
+ N++ TD+ G + A++ ++E+VQ L V + G+T A G V
Sbjct: 182 KRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDA-GTYVNIPDRSGDTVLIGAVRGGHV 240
Query: 1110 KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAV 1169
+++ L++ + I R + ++ T L A E G+A +VR +++ + G T +
Sbjct: 241 EIVRALLQ--KYADIDIRGQ-DNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPL 297
Query: 1170 HLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVP 1222
A + + V++++ + K G TPLHI A G++ + ELL P
Sbjct: 298 IKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHI-AIRGRSRKLAELLLRNP 349
Score = 105 bits (252), Expect = 2e-21
Identities = 94/360 (26%), Positives = 165/360 (45%), Gaps = 22/360 (6%)
Query: 1102 IAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDE 1161
IAA QG++++++EL+K G L++ T L A++ GH +V L++ G +
Sbjct: 2 IAAEQGNLEIVKELIK---NGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHR 58
Query: 1162 NRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
+ G TA+ A G T+V++++ S + + P+ AA G A+ V LL +
Sbjct: 59 DMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNG 118
Query: 1222 PGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYN 1281
S+ + G TPL AA G+ V+ LL + G D N
Sbjct: 119 AKVNCSD-------------KYGTTPLVWAARKGHLECVKHLL-AMGADVDQ-EGANSMT 163
Query: 1282 PLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINA 1341
L +A GG+ V +L R+ + + TD+ G T L IAS GH ++V+ LL G +N
Sbjct: 164 ALIVAVKGGYTQSVKEILKRNPNV-NLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI 222
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
D++G T L A + GH+ +V+ L + A N +++A + + ++ +L
Sbjct: 223 PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQC 282
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKER 1461
DT+ D ++ + NI + E +L A V K + ++++ + + R
Sbjct: 283 NPDTEICTKDGE---TPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSR 339
Score = 103 bits (247), Expect = 7e-21
Identities = 104/385 (27%), Positives = 175/385 (45%), Gaps = 24/385 (6%)
Query: 968 LAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTL 1027
+AAE G L++ L+ N A N + + TAL A+ G+ H+V+ L++ ++ +
Sbjct: 2 IAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLK-CGVNLEHRDM 60
Query: 1028 KKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPN 1087
T L A G+ +V +LLL GAN T PI AA ++++V L LQ
Sbjct: 61 GGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAK 120
Query: 1088 LVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADV 1147
V + K G T AA +G ++ ++ L+ G + N T L +A +GG+
Sbjct: 121 -VNCSDKYGTTPLVWAARKGHLECVKHLLAM---GADVDQEGANSMTALIVAVKGGYTQS 176
Query: 1148 VRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAY 1207
V+ +++ + ++ G TA+ +A++ GHT ++ + T + G T L A
Sbjct: 177 VKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVR 236
Query: 1208 YGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSA 1267
G E VR LL + + G + T L+ A GN +VR +L
Sbjct: 237 GGHVEIVRALLQKYAD------------IDIRG-QDNKTALYWAVEKGNATMVRDIL-QC 282
Query: 1268 GVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQ 1327
+ + ++G PL A ++ +V LLL + A+ + + D+ G T LHIA +
Sbjct: 283 NPDTEICT-KDGETPLIKATKMRNIEVVELLLDKGAK-VSAVDKKGDTPLHIAIRGRSRK 340
Query: 1328 MVEVLL---GQGAEINATDKNGWTP 1349
+ E+LL G + +K G TP
Sbjct: 341 LAELLLRNPKDGRLLYRPNKAGETP 365
Score = 99 bits (238), Expect = 8e-20
Identities = 99/374 (26%), Positives = 164/374 (43%), Gaps = 20/374 (5%)
Query: 1035 LAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTK 1094
+AA G +E+ K L++ GAN + D + +A++ + +V+ L+ NL
Sbjct: 2 IAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDM- 60
Query: 1095 DGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRA 1154
G T A +G V+E L+ ++ L P+ AA GHAD+V +L++
Sbjct: 61 GGWTALMWACYKGRTDVVELLLSHGANPSVTG---LYSVYPIIWAAGRGHADIVHLLLQN 117
Query: 1155 GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETV 1214
GA ++ G T + AA GH + + + +T L +A G ++V
Sbjct: 118 GAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSV 177
Query: 1215 RELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAA 1274
+E+L P V+L + G T L +A+ G+ +V+ LL+ AG +
Sbjct: 178 KEILKRNPN---------VNLTD----KDGNTALMIASKEGHTEIVQDLLD-AGTYVNIP 223
Query: 1275 SNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG 1334
+ +G L A GGH+ IV LL + A++ + KT L+ A G+ MV +L
Sbjct: 224 -DRSGDTVLIGAVRGGHVEIVRALLQKYADI-DIRGQDNKTALYWAVEKGNATMVRDILQ 281
Query: 1335 QGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDV 1394
+ K+G TPL A K ++ VV+LL + GA + P+ A +
Sbjct: 282 CNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKL 341
Query: 1395 LEYLLHKEHDTQSL 1408
E LL D + L
Sbjct: 342 AELLLRNPKDGRLL 355
Score = 99 bits (238), Expect = 8e-20
Identities = 83/308 (26%), Positives = 151/308 (49%), Gaps = 15/308 (4%)
Query: 871 VVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGW 930
VV+ L+ +GA+ S+ ++ + A G+ D++ H+ + ++ +N + G
Sbjct: 77 VVELLLSHGANPSVTGLYSVYPII-WAAGRGHADIV-----HLLLQNGAK-VNCSDKYGT 129
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL+ A +GH++ V LL A VD +AL +A + GY Q +L +N
Sbjct: 130 TPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNL 189
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
++G TAL +A+ G+ +V+ L+ D +++ T L A G +E+ + LL+
Sbjct: 190 TDKDGNTALMIASKEGHTEIVQDLL-DAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQ 248
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
A+ID + + ++ A + + +V+ LQ +P+ + TKDG T A +++
Sbjct: 249 KYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEIC-TKDGETPLIKATKMRNIE 307
Query: 1111 VIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR---AGASCTDENRAGLT 1167
V+E L+ D+ +SA +K D TPL +A G + +L+R G N+AG T
Sbjct: 308 VVELLL--DKGAKVSAVDKKGD-TPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGET 364
Query: 1168 AVHLAAEH 1175
++ H
Sbjct: 365 PYNIDCSH 372
Score = 98.3 bits (234), Expect = 3e-19
Identities = 101/366 (27%), Positives = 174/366 (47%), Gaps = 23/366 (6%)
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDE 1060
+AA G +VK LI++ A ++ L T L A+ G + + + LL+ G N++ D
Sbjct: 2 IAAEQGNLEIVKELIKN-GANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDM 60
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDR 1120
G + A ++VV+L L N + AA +G ++ L++
Sbjct: 61 GGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIW-AAGRGHADIVHLLLQ--N 117
Query: 1121 TGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHT-N 1179
++ +K +TPL AA GH + V+ L+ GA E +TA+ +A + G+T +
Sbjct: 118 GAKVNCSDKYG-TTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQS 176
Query: 1180 VLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVL 1239
V ++++ + ++ K G T L IA+ G E V++LL +A T V++
Sbjct: 177 VKEILKRNPNVNLTDKD-GNTALMIASKEGHTEIVQDLL---------DAGTYVNIPD-- 224
Query: 1240 GAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLL 1299
SG T L A G+ +VR LL D +N L+ A G+ ++V +L
Sbjct: 225 --RSGDTVLIGAVRGGHVEIVRALLQKYA-DIDIRGQDNK-TALYWAVEKGNATMVRDIL 280
Query: 1300 SRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
+ + T + G+T L A+ + ++VE+LL +GA+++A DK G TPLH A +
Sbjct: 281 QCNPDTEICT-KDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSR 339
Query: 1360 NVVKLL 1365
+ +LL
Sbjct: 340 KLAELL 345
Score = 90.2 bits (214), Expect = 7e-17
Identities = 109/421 (25%), Positives = 188/421 (44%), Gaps = 43/421 (10%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR--GG 727
AA G++ I+ L++ G + ++ DN+TAL A + +VE LL G ++ R GG
Sbjct: 3 AAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 62
Query: 728 KQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
T L A D L LL GA P+ + P+ AA G+ + LLL++G
Sbjct: 63 ---WTALMWACYKGRTDVVEL-LLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNG 118
Query: 788 GDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDG 847
KV D G TPL A R + V+HL+ D VD++G
Sbjct: 119 ------AKVNCSDKY-GTTPLVWAARKGHLECVKHLLAMGAD-------------VDQEG 158
Query: 848 ASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMT 907
A+++ T V + Q VK +++ +V+L T + TA + G+ +++
Sbjct: 159 ANSM------TALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASKEGHTEIVQ 211
Query: 908 EMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALH 967
+++ D +N + G T L+ A GH+++V LL +A +D+ + ++AL+
Sbjct: 212 DLL------DAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALY 265
Query: 968 LAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTL 1027
A E G + +L ++G T L A +V+ L+ D A + +
Sbjct: 266 WAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLL-DKGAKVSAVDK 324
Query: 1028 KKQTPLHLAAASGQIEVCKLLL---ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
K TPLH+A ++ +LLL + G + ++ G+ P + + S + Q+F +
Sbjct: 325 KGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGAR 384
Query: 1085 H 1085
H
Sbjct: 385 H 385
Score = 67.3 bits (157), Expect = 6e-10
Identities = 81/356 (22%), Positives = 159/356 (44%), Gaps = 35/356 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
D ++ +A++ GHV I+ LL+ G +++ +TAL A + VVE LL +GA+
Sbjct: 28 DNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGAN 87
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ G P+ AA D +LL++GA N + + G TP+ AA+ G+L +
Sbjct: 88 PSVT-GLYSVYPIIWAAGRGHAD-IVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVK 145
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LL G D + T L +A + V+ +++ ++
Sbjct: 146 HLLAMGAD-------VDQEGANSMTALIVAVKGGYTQSVKEILK----------RNPNVN 188
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
D+DG +AL A K ++V+ L++ G V++ R + +T G
Sbjct: 189 LTDKDGNTALMIASK---------EGHTEIVQDLLDAGTYVNIPDR-SGDTVLIGAVRGG 238
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVE 961
+ +++ ++ + D+ R + + ++ W A +G+ +V +L + ++ +
Sbjct: 239 HVEIVRALLQKYADIDI-RGQDNKTALYW-----AVEKGNATMVRDILQCNPDTEICTKD 292
Query: 962 GRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRD 1017
G + L A + ++V + LL A +++ + G T LH+A L + L+R+
Sbjct: 293 GETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRN 348
Score = 64.1 bits (149), Expect = 5e-09
Identities = 50/176 (28%), Positives = 82/176 (46%), Gaps = 6/176 (3%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
+L + G L++A + G+ +V++LL A T + +GDT L A R V++ R
Sbjct: 188 NLTDKDGNTALMIASKEGHTEIVQDLLDAGT--YVNIPDRSGDTVLIGAVRGGHVEIVRA 245
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGH 176
L+ A +D +T L+ A +G+ +V+ + I + TP+ A + +
Sbjct: 246 LLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRN 305
Query: 177 AAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF---KKGVYLHMPNK 229
++ELL DK A + K G T +HIA A +L K G L+ PNK
Sbjct: 306 IEVVELLLDK-GAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNK 360
Score = 58.8 bits (136), Expect = 2e-07
Identities = 51/169 (30%), Positives = 77/169 (45%), Gaps = 11/169 (6%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DG ++ A++ GH I+ LL G V++ T L AV +V LL AD
Sbjct: 193 DGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYAD 252
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALM-LLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
+ IR G+ +T L+ A + G+ + +L+ T+DG TP+ A K N+ +
Sbjct: 253 IDIR-GQDNKTALYWA--VEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVV 309
Query: 781 VLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKD 829
LLL+ G KV D G+TPL +A R + L+ KD
Sbjct: 310 ELLLDKG------AKVSAVD-KKGDTPLHIAIRGRSRKLAELLLRNPKD 351
Score = 57.2 bits (132), Expect = 6e-07
Identities = 37/126 (29%), Positives = 64/126 (50%), Gaps = 3/126 (2%)
Query: 105 AARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED 164
AA R D+ +L+ GA V+ ++ G TPL AA +G VK+ + A+
Sbjct: 102 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 161
Query: 165 RTPMHLAAENGHA-AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
T + +A + G+ ++ E+L K ++ KDG+T + IAS GH + L G Y
Sbjct: 162 MTALIVAVKGGYTQSVKEIL--KRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY 219
Query: 224 LHMPNK 229
+++P++
Sbjct: 220 VNIPDR 225
Score = 45.2 bits (102), Expect = 0.003
Identities = 39/149 (26%), Positives = 61/149 (40%), Gaps = 3/149 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL+ A G+ V+ LL+ + TAL +A + + ++
Sbjct: 128 GTTPLVWAARKGHLECVKHLLAMGADVDQEGANSM--TALIVAVKGGYTQSVKEILKRNP 185
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+ T+ G T L IA+ EG +V+ I D T + A GH I+
Sbjct: 186 NVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRA 245
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHA 211
L K+ A I R +D T ++ A G+A
Sbjct: 246 LLQKY-ADIDIRGQDNKTALYWAVEKGNA 273
Score = 43.6 bits (98), Expect = 0.008
Identities = 38/163 (23%), Positives = 66/163 (40%), Gaps = 3/163 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L+ A + G+ +V ELL L+ G TAL A + D+ +L+ +GA
Sbjct: 33 LISASKEGHVHIVEELLKCGV--NLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSV 90
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
T P+ AA G +V A +D TP+ AA GH ++ L
Sbjct: 91 TGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLL-A 149
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
A + + + T + +A G+ + K+ +++ +K
Sbjct: 150 MGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDK 192
Score = 35.5 bits (78), Expect = 2.1
Identities = 25/85 (29%), Positives = 39/85 (45%), Gaps = 1/85 (1%)
Query: 137 IAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTK 196
IAA +G+ +VK AN + D ++ T + A++ GH I+E L K ++ R
Sbjct: 2 IAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELL-KCGVNLEHRDM 60
Query: 197 DGSTLMHIASLNGHADCAMMLFKKG 221
G T + A G D +L G
Sbjct: 61 GGWTALMWACYKGRTDVVELLLSHG 85
>BX640903-1|CAE45949.1| 714|Homo sapiens hypothetical protein
protein.
Length = 714
Score = 105 bits (253), Expect = 1e-21
Identities = 98/338 (28%), Positives = 145/338 (42%), Gaps = 32/338 (9%)
Query: 1093 TKDGNTCAHIAAIQGSVKV-IEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
T++G + H+ I G K I LM G+ +R N T L LA +A+++ L
Sbjct: 182 TENGLSLLHLCCICGGKKSHIRTLML---KGLRPSRLTRNGFTALHLAVYKDNAELITSL 238
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQA 1211
+ +GA GLTA+H+A GH DV+ + TPLHIAAYYG
Sbjct: 239 LHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE 298
Query: 1212 ETVRELLS-----HVPGTVKSE-----APTGVSLVPVLGAESGL------------TPLH 1249
+ R LL +V G V + G + L E G PLH
Sbjct: 299 QVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLH 358
Query: 1250 LAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSA-ELLHS 1308
+ G+ ++V+ LL S N G PLHLAC+ G + ++ S E L
Sbjct: 359 FCSRFGHHDMVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTK 418
Query: 1309 TDRHGKTGLHIASTHGH-YQMVEVLLGQGA-EINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
+ +T H A T+G +V+ LL Q IN ++G T LH A GH+ +V+ L
Sbjct: 419 ENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLL 478
Query: 1367 ESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
++GA + + C P + ++ L + K HD
Sbjct: 479 DNGA---DMSLVACDPSRSSGEKDEQTCLMWAYEKGHD 513
Score = 104 bits (250), Expect = 3e-21
Identities = 91/346 (26%), Positives = 156/346 (45%), Gaps = 28/346 (8%)
Query: 1033 LHLAA-ASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
LHL G+ + L+ G G +H A + +E++ L + +
Sbjct: 189 LHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGAD-IQQ 247
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
G T HIA I G ++ + L++ ++ ++ + TPL +AA GH V R+L
Sbjct: 248 VGYGGLTALHIATIAGHLEAADVLLQHGAN--VNIQDAVF-FTPLHIAAYYGHEQVTRLL 304
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDV-MRSTNTLRISSK-KLGLTPLHIAAYYG 1209
++ GA G +HLA+ G N+ + M + ++++ PLH + +G
Sbjct: 305 LKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFG 364
Query: 1210 QAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGV 1269
+ V+ LL +S+ +V + G TPLHLA YNG V + ++ +G
Sbjct: 365 HHDMVKYLL-------QSDLEVQPHVVNIYGD----TPLHLACYNGKFEVAKEIIQISGT 413
Query: 1270 QADAASNENGYNPLHLAC-FGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQM 1328
++ N H AC +G + +V LL ++ ++ R G TGLH A HGH ++
Sbjct: 414 ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL 473
Query: 1329 VEVLLGQGAEI---------NATDKNGWTPLHCAAKAGHLNVVKLL 1365
V+ LL GA++ ++ +K+ T L A + GH +V LL
Sbjct: 474 VQFLLDNGADMSLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 519
Score = 99.5 bits (237), Expect = 1e-19
Identities = 59/167 (35%), Positives = 89/167 (53%), Gaps = 7/167 (4%)
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS-NENGYNPLHLACFGGHMSIVGLLLSR 1301
+G T LHLA Y N ++ LL+S AD G LH+A GH+ +LL
Sbjct: 218 NGFTALHLAVYKDNAELITSLLHSG---ADIQQVGYGGLTALHIATIAGHLEAADVLLQH 274
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNV 1361
A + + D T LHIA+ +GH Q+ +LL GA++N + + G PLH A+ G LN+
Sbjct: 275 GANV-NIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNI 333
Query: 1362 VKLLCESG--ASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQ 1406
KLL E G A ++ N + P+ F + H+D+++YLL + + Q
Sbjct: 334 AKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDMVKYLLQSDLEVQ 380
Score = 89.4 bits (212), Expect = 1e-16
Identities = 96/368 (26%), Positives = 160/368 (43%), Gaps = 33/368 (8%)
Query: 833 ESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHET 892
E+ S ++ E+G S LH C I + ++ L+ G S TR N T
Sbjct: 171 EAFSKVNLNYRTENGLSLLHLCC--------ICGGKKSHIRTLMLKGLRPSRLTR-NGFT 221
Query: 893 AFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
A H N +++T ++ H S AD+ + G T L IA GH++ + LL +
Sbjct: 222 ALHLAVYKDNAELITSLL-H-SGADIQQV----GYGGLTALHIATIAGHLEAADVLLQHG 275
Query: 953 ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVK 1012
A V++ D + LH+AA +G+ QV LL A +N G LHLA+ G+ ++ K
Sbjct: 276 ANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAK 335
Query: 1013 FLIRD-HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID--ATDELGQKPIHAA 1069
L+ + A ++ + PLH + G ++ K LL+ + + G P+H A
Sbjct: 336 LLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDMVKYLLQSDLEVQPHVVNIYGDTPLHLA 395
Query: 1070 AQNNYSEVVQLFLQ-QHPNLVMATTKDGNTCAHIAAIQG-SVKVIEELMKFDRTGVISAR 1127
N EV + +Q + T H A G S+ +++ L+ VI+
Sbjct: 396 CYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLD---QNVININ 452
Query: 1128 NKLNDS-TPLQLAAEGGHADVVRVLVRAGA-----SCTDENRAG----LTAVHLAAEHGH 1177
++ D T L A GH +V+ L+ GA +C +G T + A E GH
Sbjct: 453 HQGRDGHTGLHSACYHGHIRLVQFLLDNGADMSLVACDPSRSSGEKDEQTCLMWAYEKGH 512
Query: 1178 TNVLDVMR 1185
++ +++
Sbjct: 513 DAIVTLLK 520
Score = 83.0 bits (196), Expect = 1e-14
Identities = 85/292 (29%), Positives = 134/292 (45%), Gaps = 27/292 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G ++H A + +I +LL G + TALHIA + + LL +GA+
Sbjct: 218 NGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGAN 277
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
V+I+ TPLHIAA ++ +LLK GA N + E G P+H+A+ G L
Sbjct: 278 VNIQDA-VFFTPLHIAAYY-GHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAK 335
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LL+E+G K V D PL R D+V++L++ D + +
Sbjct: 336 LLMEEGS----KADVNAQD-NEDHVPLHFCSRFGHHDMVKYLLQ--SDLEVQP------H 382
Query: 842 AVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAG 901
V+ G + LH AC K EV +++++ +G + + ETAFH G
Sbjct: 383 VVNIYGDTPLHLACYNGKFEVA-----KEIIQI---SGTESLTKENIFSETAFHSACTYG 434
Query: 902 NNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHA 953
+ +++ + +V +N Q G T L AC+ GH++LV LL N A
Sbjct: 435 KS---IDLVKFLLDQNVIN-INHQGRDGHTGLHSACYHGHIRLVQFLLDNGA 482
Score = 81.8 bits (193), Expect = 2e-14
Identities = 54/183 (29%), Positives = 88/183 (48%), Gaps = 4/183 (2%)
Query: 1242 ESGLTPLHLAAY-NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLS 1300
E+GL+ LHL G ++ +R L+ G++ + NG+ LHLA + + ++ LL
Sbjct: 183 ENGLSLLHLCCICGGKKSHIRTLMLK-GLRPSRLTR-NGFTALHLAVYKDNAELITSLLH 240
Query: 1301 RSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
A++ G T LHIA+ GH + +VLL GA +N D +TPLH AA GH
Sbjct: 241 SGADI-QQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQ 299
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMV 1420
V +LL + GA + P+ A+++ ++ + L+ + D L
Sbjct: 300 VTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHF 359
Query: 1421 CSK 1423
CS+
Sbjct: 360 CSR 362
Score = 78.2 bits (184), Expect = 3e-13
Identities = 88/311 (28%), Positives = 139/311 (44%), Gaps = 33/311 (10%)
Query: 679 INTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAA 738
I TL+ KG T + +TALH+AV ++ +LL GAD+ + G T LHIA
Sbjct: 202 IRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQ-QVGYGGLTALHIAT 260
Query: 739 RIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCI 798
I + A +LL+ GA N TP+H+AA +G+ LLL+ G D +V
Sbjct: 261 -IAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEV-- 317
Query: 799 YDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVT 858
G+ PL +A +I + L+E +G S A ++A D + LH+ +
Sbjct: 318 -----GDRPLHLASAKGFLNIAKLLME-----EG---SKADVNAQDNEDHVPLHFCSRF- 363
Query: 859 KEEVKIPTADRQVVKCLIENGADVSLQTRHNH-ETAFHYCAIAGNNDVMTEMIAHISTAD 917
+VK L+++ +V + + +T H G +V E+I T
Sbjct: 364 --------GHHDMVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGT-- 413
Query: 918 VSRALNRQNSIGWTPLLIACHRG-HMQLVNTLL-TNHARVDVFDVEGRSALHLAAEHGYL 975
+L ++N T AC G + LV LL N ++ +G + LH A HG++
Sbjct: 414 --ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHI 471
Query: 976 QVCDALLTNKA 986
++ LL N A
Sbjct: 472 RLVQFLLDNGA 482
Score = 67.7 bits (158), Expect = 4e-10
Identities = 79/302 (26%), Positives = 141/302 (46%), Gaps = 35/302 (11%)
Query: 661 FDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
+ G ++H A GH+ + LLQ G +V++ +T LHIA V LL +GA
Sbjct: 250 YGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA 309
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSG--AGPNKATEDGMTPVHVAAKFGNLA 778
DV++ G+ + PLH+A+ A +L++ G A N + P+H ++FG+
Sbjct: 310 DVNV-SGEVGDRPLHLAS-AKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHD 367
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LL+ + ++ V IY G+TPL +AC + ++ + +I+ ES++
Sbjct: 368 MVKYLLQSDLE-VQPHVVNIY----GDTPLHLACYNGKFEVAKEIIQI---SGTESLTKE 419
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLI-ENGADVSLQTRHNHETAFHYC 897
I + +A H AC K +VK L+ +N +++ Q R H T H
Sbjct: 420 NIFS-----ETAFHSACTYGK--------SIDLVKFLLDQNVININHQGRDGH-TGLHSA 465
Query: 898 AIAGNNDVMTEMIAH-----ISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
G+ ++ ++ + + D SR+ ++ T L+ A +GH +V TLL ++
Sbjct: 466 CYHGHIRLVQFLLDNGADMSLVACDPSRSSGEKDE--QTCLMWAYEKGHDAIV-TLLKHY 522
Query: 953 AR 954
R
Sbjct: 523 KR 524
Score = 67.3 bits (157), Expect = 6e-10
Identities = 56/195 (28%), Positives = 83/195 (42%), Gaps = 4/195 (2%)
Query: 28 QKDLQRLELSFIELNKERAKQKEWKKLIRDLVFQRGKVPL-LLAVEAGNQSMVRELLSAQ 86
+ DLQ E EL + + K+ + + G L L + G +S +R L+
Sbjct: 150 EDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKG 209
Query: 87 TAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPL 146
T G TALHLA + + ++ L+ GA + G T LHIA G
Sbjct: 210 LRPS--RLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEA 267
Query: 147 VKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIAS 206
AN I D TP+H+AA GH + LL KF A + + G +H+AS
Sbjct: 268 ADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLL-KFGADVNVSGEVGDRPLHLAS 326
Query: 207 LNGHADCAMMLFKKG 221
G + A +L ++G
Sbjct: 327 AKGFLNIAKLLMEEG 341
Score = 66.9 bits (156), Expect = 7e-10
Identities = 49/173 (28%), Positives = 79/173 (45%), Gaps = 5/173 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G L LAV N ++ LL + ++ G TALH+A ++ A +L+ +
Sbjct: 217 RNGFTALHLAVYKDNAELITSLL--HSGADIQQVGYGGLTALHIATIAGHLEAADVLLQH 274
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+ + TPLHIAA G E + + A+ ++ P+HLA+ G I
Sbjct: 275 GANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIA 334
Query: 181 ELLADK-FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG--VYLHMPNKY 230
+LL ++ KA + + + +H S GH D L + V H+ N Y
Sbjct: 335 KLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDMVKYLLQSDLEVQPHVVNIY 387
Score = 49.2 bits (112), Expect = 2e-04
Identities = 40/164 (24%), Positives = 64/164 (39%), Gaps = 5/164 (3%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL LA G ++ + L+ + + A LH +R DM + L+
Sbjct: 318 GDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDMVKYLLQSDL 377
Query: 123 VVD--ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE--DRTPMHLAAENGHAA 178
V N G TPLH+A G + K + ++ T H A G +
Sbjct: 378 EVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSI 437
Query: 179 -IIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+++ L D+ +I + +DG T +H A +GH L G
Sbjct: 438 DLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNG 481
Score = 44.4 bits (100), Expect = 0.004
Identities = 34/132 (25%), Positives = 58/132 (43%), Gaps = 11/132 (8%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARR-RDVDMARILVDYG 121
G PL LA G + +E++ E L +TA H A + +D+ + L+D
Sbjct: 388 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQN 447
Query: 122 AV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIA---------DNEDRTPMHLA 171
+ ++ G T LH A G LV++ A+ ++ + +++T + A
Sbjct: 448 VININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMSLVACDPSRSSGEKDEQTCLMWA 507
Query: 172 AENGHAAIIELL 183
E GH AI+ LL
Sbjct: 508 YEKGHDAIVTLL 519
Score = 33.5 bits (73), Expect = 8.3
Identities = 20/66 (30%), Positives = 34/66 (51%), Gaps = 1/66 (1%)
Query: 166 TPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
T +HLA +A +I L A I + G T +HIA++ GH + A +L + G ++
Sbjct: 221 TALHLAVYKDNAELITSLLHS-GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVN 279
Query: 226 MPNKYF 231
+ + F
Sbjct: 280 IQDAVF 285
>X69838-1|CAA49491.1| 1001|Homo sapiens G9a protein.
Length = 1001
Score = 105 bits (251), Expect = 2e-21
Identities = 82/277 (29%), Positives = 133/277 (48%), Gaps = 6/277 (2%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH-NAMI 1022
SA+ L G + AL+ ++ K R L+L+ G V ++ D+ +
Sbjct: 410 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 469
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++
Sbjct: 470 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YM 528
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
Q V + +DG+TC H AA G+++++ L+ + V +A++ TP+ AAE
Sbjct: 529 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQDS-GGWTPIIWAAEH 586
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
H +V+R+L+ GA T + +H A+ G + +V+ + + G TPL
Sbjct: 587 KHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPL 646
Query: 1203 HIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
HIAA + V LS P E T L P
Sbjct: 647 HIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 683
Score = 91.1 bits (216), Expect = 4e-17
Identities = 65/213 (30%), Positives = 108/213 (50%), Gaps = 6/213 (2%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 477 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 535
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
T LH AA G +E+ LLL G +++A D G PI AA++ + EV+++
Sbjct: 536 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 595
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L + ++ + T + N C H A+ GS + E L+ + + A N D TPL +AA
Sbjct: 596 LTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGD-TPLHIAAR 651
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ D V + + GA+ N+ G TA L E
Sbjct: 652 ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 684
Score = 81.4 bits (192), Expect = 3e-14
Identities = 76/249 (30%), Positives = 113/249 (45%), Gaps = 18/249 (7%)
Query: 1101 HIAAIQGSV-KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
+++ QG + KVI LM D ++ + TPL AA+ G ++ VL++AGA+
Sbjct: 446 YLSVKQGELQKVI--LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 503
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
++ T + A + H V M S ++ G T LH AA G E V LLS
Sbjct: 504 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 563
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G V A G TP+ AA + + V+R+LL + G NE
Sbjct: 564 --TGQVDVNAQDS----------GGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEEN 610
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
LH A F G +I +LL+ +L H+ + HG T LHIA+ ++ V + L +GA
Sbjct: 611 IC-LHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 668
Query: 1340 NATDKNGWT 1348
+K G T
Sbjct: 669 ELRNKEGDT 677
Score = 79.4 bits (187), Expect = 1e-13
Identities = 50/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+S TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 474 QSKRTPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQR 531
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLN 1360
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+ AA+ H+
Sbjct: 532 GG-CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIE 590
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
V+++L GA N + +A+ + E LL+ D ++
Sbjct: 591 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 638
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/207 (30%), Positives = 96/207 (46%), Gaps = 15/207 (7%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 478 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 536
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
S+ E G T LH AA GN +V LLL++ V +A + G+ P+ A
Sbjct: 537 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA-QDSGGWTPIIWA 583
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
H+ ++ +LL+R A++ TD LH AS G + EVLL +++A + +G
Sbjct: 584 AEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 642
Query: 1347 WTPLHCAAKAGHLNVVKLLCESGASPK 1373
TPLH AA+ + + V L GA+P+
Sbjct: 643 DTPLHIAARESYHDCVLLFLSRGANPE 669
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL A +G +++ + LL A ++ D + R+ L A + +L+V ++ + S
Sbjct: 478 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 537
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K +G T LH AA G +V L+ ++ TP+ AA IEV ++LL
Sbjct: 538 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 597
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
GA++ TD +H A+ + + ++ L +L A G+T HIAA +
Sbjct: 598 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHD 656
Query: 1111 VIEELMKFDRTGVISARNKLNDS 1133
+ L+ R RNK D+
Sbjct: 657 CV--LLFLSRGANPELRNKEGDT 677
Score = 69.3 bits (162), Expect = 1e-10
Identities = 67/253 (26%), Positives = 117/253 (46%), Gaps = 31/253 (12%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++++ K G L ++L+L D DP ++ D + TPL A + +I L++
Sbjct: 445 LYLSVKQGELQKVILMLLDNLDPNFQS-----DQQSKRTPLHAAAQKGSVEICHVLLQ-- 497
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A I+AVD+ + L A + +V + +++ G V
Sbjct: 498 --------AGANINAVDKQQRTPLMEA---------VVNNHLEVARYMVQRGGCV-YSKE 539
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
+ T H+ A GN ++++ ++ ST V +N Q+S GWTP++ A H++++
Sbjct: 540 EDGSTCLHHAAKIGNLEMVSLLL---STGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRM 594
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY 1007
LLT A V + D E LH A+ G + + LL + +++ +G T LH+AA Y
Sbjct: 595 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 654
Query: 1008 AHLV-KFLIRDHN 1019
V FL R N
Sbjct: 655 HDCVLLFLSRGAN 667
Score = 67.7 bits (158), Expect = 4e-10
Identities = 46/172 (26%), Positives = 84/172 (48%), Gaps = 4/172 (2%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 505 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 562
Query: 119 DYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
G V V+A + G TP+ AA +++ A+ + DNE+ +H A+ G A
Sbjct: 563 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 622
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
AI E+L + + + G T +HIA+ + DC ++ +G + NK
Sbjct: 623 AIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 673
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 583 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 641
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 642 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 700
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 701 GVGNRAIRTEKIICRDVARGYENVPIPC 728
Score = 64.1 bits (149), Expect = 5e-09
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 16/200 (8%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 478 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 524
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
R ++ G + E+G LH A G++ +V LLLS +++ D G T +
Sbjct: 525 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 582
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLN 1379
A+ H H +++ +LL +GA++ TD LH A+ G + ++L + +
Sbjct: 583 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 642
Query: 1380 CAPIWFAASENHND-VLEYL 1398
P+ AA E+++D VL +L
Sbjct: 643 DTPLHIAARESYHDCVLLFL 662
Score = 52.4 bits (120), Expect = 2e-05
Identities = 46/192 (23%), Positives = 81/192 (42%), Gaps = 3/192 (1%)
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGK-TGLHIASTHGHYQMVEVLLGQGAEINA 1341
L+L+ G + V L+L + + +D+ K T LH A+ G ++ VLL GA INA
Sbjct: 445 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 504
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
DK TPL A HL V + + + G S+ + AA + +++ LL
Sbjct: 505 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 564
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKER 1461
+ D + ++ + H +I + +L A V NI ++ ++
Sbjct: 565 GQVDVNAQDSGG--WTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 622
Query: 1462 AKDLIAAGKQCE 1473
A + +C+
Sbjct: 623 AIAEVLLNARCD 634
Score = 50.0 bits (114), Expect = 9e-05
Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 2/156 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L L+V+ G V +L ++ + T LH AA++ V++ +L+ GA ++A
Sbjct: 445 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 504
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED-RTPMHLAAENGHAAIIELLAD 185
+ +TPL A + +Y R + ED T +H AA+ G+ ++ LL
Sbjct: 505 VDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 563
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + + G T + A+ + H + ML +G
Sbjct: 564 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 599
Score = 49.6 bits (113), Expect = 1e-04
Identities = 41/159 (25%), Positives = 68/159 (42%), Gaps = 4/159 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + GN MV LLS + + A G T + AA + +++ R+L+ GA
Sbjct: 542 GSTCLHHAAKIGNLEMVSLLLSTGQVD-VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGA 600
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
V T+ LH A+ G + + R + + TP+H+AA E+ H ++
Sbjct: 601 DVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 660
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L+ + R K+G T + A+ L +K
Sbjct: 661 FLSRGANPEL--RNKEGDTAWDLTPERSDVWFALQLNRK 697
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 480 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 539
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
+ T LH AA+I + + +L+L N G TP+ AA+ ++ + +LL
Sbjct: 540 -EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 598
Query: 787 GGD 789
G D
Sbjct: 599 GAD 601
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 478 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 535
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 536 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 565
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 576 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 633
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 634 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 693
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 694 LNRKLRLGVGNR 705
Score = 36.7 bits (81), Expect = 0.89
Identities = 63/272 (23%), Positives = 114/272 (41%), Gaps = 39/272 (14%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLATLVLLLEDGGDPL 791
L+++ + + K LMLL + PN ++ TP+H AA+ G++ +LL+ G +
Sbjct: 445 LYLSVKQGELQKVILMLLDN-LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 503
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
K TPL A + ++ R++++ +G V + +EDG++ L
Sbjct: 504 AVDK-------QQRTPLMEAVVNNHLEVARYMVQ-----RGGCVYSK-----EEDGSTCL 546
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENG-ADVSLQTRHNHETAFHYCAIAGNNDVMTEMI 910
H+A K+ + ++V L+ G DV+ Q T + A + +V+ ++
Sbjct: 547 HHAAKI---------GNLEMVSLLLSTGQVDVNAQDSGGW-TPIIWAAEHKHIEVIRMLL 596
Query: 911 AHISTADVSRALNRQN-SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
ADV+ N +N + W A G + LL + + G + LH+A
Sbjct: 597 TR--GADVTLTDNEENICLHW-----ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 649
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A Y L+ A + + G TA L
Sbjct: 650 ARESYHDCVLLFLSRGANPELRNKEGDTAWDL 681
>BX005460-6|CAM26152.1| 922|Homo sapiens euchromatic histone-lysine
N-methyltransferase 2 protein.
Length = 922
Score = 105 bits (251), Expect = 2e-21
Identities = 82/277 (29%), Positives = 133/277 (48%), Gaps = 6/277 (2%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH-NAMI 1022
SA+ L G + AL+ ++ K R L+L+ G V ++ D+ +
Sbjct: 331 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 390
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++
Sbjct: 391 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YM 449
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
Q V + +DG+TC H AA G+++++ L+ + V +A++ TP+ AAE
Sbjct: 450 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQDS-GGWTPIIWAAEH 507
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
H +V+R+L+ GA T + +H A+ G + +V+ + + G TPL
Sbjct: 508 KHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPL 567
Query: 1203 HIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
HIAA + V LS P E T L P
Sbjct: 568 HIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 604
Score = 91.1 bits (216), Expect = 4e-17
Identities = 65/213 (30%), Positives = 108/213 (50%), Gaps = 6/213 (2%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 398 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 456
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
T LH AA G +E+ LLL G +++A D G PI AA++ + EV+++
Sbjct: 457 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 516
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L + ++ + T + N C H A+ GS + E L+ + + A N D TPL +AA
Sbjct: 517 LTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGD-TPLHIAAR 572
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ D V + + GA+ N+ G TA L E
Sbjct: 573 ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 605
Score = 81.4 bits (192), Expect = 3e-14
Identities = 76/249 (30%), Positives = 113/249 (45%), Gaps = 18/249 (7%)
Query: 1101 HIAAIQGSV-KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
+++ QG + KVI LM D ++ + TPL AA+ G ++ VL++AGA+
Sbjct: 367 YLSVKQGELQKVI--LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 424
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
++ T + A + H V M S ++ G T LH AA G E V LLS
Sbjct: 425 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 484
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G V A G TP+ AA + + V+R+LL + G NE
Sbjct: 485 --TGQVDVNAQDS----------GGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEEN 531
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
LH A F G +I +LL+ +L H+ + HG T LHIA+ ++ V + L +GA
Sbjct: 532 IC-LHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 589
Query: 1340 NATDKNGWT 1348
+K G T
Sbjct: 590 ELRNKEGDT 598
Score = 79.4 bits (187), Expect = 1e-13
Identities = 50/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+S TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 395 QSKRTPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQR 452
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLN 1360
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+ AA+ H+
Sbjct: 453 GG-CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIE 511
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
V+++L GA N + +A+ + E LL+ D ++
Sbjct: 512 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 559
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/207 (30%), Positives = 96/207 (46%), Gaps = 15/207 (7%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 399 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 457
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
S+ E G T LH AA GN +V LLL++ V +A + G+ P+ A
Sbjct: 458 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA-QDSGGWTPIIWA 504
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
H+ ++ +LL+R A++ TD LH AS G + EVLL +++A + +G
Sbjct: 505 AEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 563
Query: 1347 WTPLHCAAKAGHLNVVKLLCESGASPK 1373
TPLH AA+ + + V L GA+P+
Sbjct: 564 DTPLHIAARESYHDCVLLFLSRGANPE 590
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL A +G +++ + LL A ++ D + R+ L A + +L+V ++ + S
Sbjct: 399 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 458
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K +G T LH AA G +V L+ ++ TP+ AA IEV ++LL
Sbjct: 459 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 518
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
GA++ TD +H A+ + + ++ L +L A G+T HIAA +
Sbjct: 519 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHD 577
Query: 1111 VIEELMKFDRTGVISARNKLNDS 1133
+ L+ R RNK D+
Sbjct: 578 CV--LLFLSRGANPELRNKEGDT 598
Score = 69.3 bits (162), Expect = 1e-10
Identities = 67/253 (26%), Positives = 117/253 (46%), Gaps = 31/253 (12%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++++ K G L ++L+L D DP ++ D + TPL A + +I L++
Sbjct: 366 LYLSVKQGELQKVILMLLDNLDPNFQS-----DQQSKRTPLHAAAQKGSVEICHVLLQ-- 418
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A I+AVD+ + L A + +V + +++ G V
Sbjct: 419 --------AGANINAVDKQQRTPLMEA---------VVNNHLEVARYMVQRGGCV-YSKE 460
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
+ T H+ A GN ++++ ++ ST V +N Q+S GWTP++ A H++++
Sbjct: 461 EDGSTCLHHAAKIGNLEMVSLLL---STGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRM 515
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY 1007
LLT A V + D E LH A+ G + + LL + +++ +G T LH+AA Y
Sbjct: 516 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 575
Query: 1008 AHLV-KFLIRDHN 1019
V FL R N
Sbjct: 576 HDCVLLFLSRGAN 588
Score = 67.7 bits (158), Expect = 4e-10
Identities = 46/172 (26%), Positives = 84/172 (48%), Gaps = 4/172 (2%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 426 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 483
Query: 119 DYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
G V V+A + G TP+ AA +++ A+ + DNE+ +H A+ G A
Sbjct: 484 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 543
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
AI E+L + + + G T +HIA+ + DC ++ +G + NK
Sbjct: 544 AIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 594
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 504 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 562
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 563 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 621
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 622 GVGNRAIRTEKIICRDVARGYENVPIPC 649
Score = 64.1 bits (149), Expect = 5e-09
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 16/200 (8%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 399 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 445
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
R ++ G + E+G LH A G++ +V LLLS +++ D G T +
Sbjct: 446 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 503
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLN 1379
A+ H H +++ +LL +GA++ TD LH A+ G + ++L + +
Sbjct: 504 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 563
Query: 1380 CAPIWFAASENHND-VLEYL 1398
P+ AA E+++D VL +L
Sbjct: 564 DTPLHIAARESYHDCVLLFL 583
Score = 52.4 bits (120), Expect = 2e-05
Identities = 46/192 (23%), Positives = 81/192 (42%), Gaps = 3/192 (1%)
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGK-TGLHIASTHGHYQMVEVLLGQGAEINA 1341
L+L+ G + V L+L + + +D+ K T LH A+ G ++ VLL GA INA
Sbjct: 366 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 425
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
DK TPL A HL V + + + G S+ + AA + +++ LL
Sbjct: 426 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 485
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKER 1461
+ D + ++ + H +I + +L A V NI ++ ++
Sbjct: 486 GQVDVNAQDSGG--WTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 543
Query: 1462 AKDLIAAGKQCE 1473
A + +C+
Sbjct: 544 AIAEVLLNARCD 555
Score = 50.0 bits (114), Expect = 9e-05
Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 2/156 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L L+V+ G V +L ++ + T LH AA++ V++ +L+ GA ++A
Sbjct: 366 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 425
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED-RTPMHLAAENGHAAIIELLAD 185
+ +TPL A + +Y R + ED T +H AA+ G+ ++ LL
Sbjct: 426 VDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 484
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + + G T + A+ + H + ML +G
Sbjct: 485 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 520
Score = 49.6 bits (113), Expect = 1e-04
Identities = 41/159 (25%), Positives = 68/159 (42%), Gaps = 4/159 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + GN MV LLS + + A G T + AA + +++ R+L+ GA
Sbjct: 463 GSTCLHHAAKIGNLEMVSLLLSTGQVD-VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGA 521
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
V T+ LH A+ G + + R + + TP+H+AA E+ H ++
Sbjct: 522 DVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 581
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L+ + R K+G T + A+ L +K
Sbjct: 582 FLSRGANPEL--RNKEGDTAWDLTPERSDVWFALQLNRK 618
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 401 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 460
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
+ T LH AA+I + + +L+L N G TP+ AA+ ++ + +LL
Sbjct: 461 -EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 519
Query: 787 GGD 789
G D
Sbjct: 520 GAD 522
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 399 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 456
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 457 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 486
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 497 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 554
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 555 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 614
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 615 LNRKLRLGVGNR 626
Score = 36.7 bits (81), Expect = 0.89
Identities = 63/272 (23%), Positives = 114/272 (41%), Gaps = 39/272 (14%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLATLVLLLEDGGDPL 791
L+++ + + K LMLL + PN ++ TP+H AA+ G++ +LL+ G +
Sbjct: 366 LYLSVKQGELQKVILMLLDN-LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 424
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
K TPL A + ++ R++++ +G V + +EDG++ L
Sbjct: 425 AVDK-------QQRTPLMEAVVNNHLEVARYMVQ-----RGGCVYSK-----EEDGSTCL 467
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENG-ADVSLQTRHNHETAFHYCAIAGNNDVMTEMI 910
H+A K+ + ++V L+ G DV+ Q T + A + +V+ ++
Sbjct: 468 HHAAKI---------GNLEMVSLLLSTGQVDVNAQDSGGW-TPIIWAAEHKHIEVIRMLL 517
Query: 911 AHISTADVSRALNRQN-SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
ADV+ N +N + W A G + LL + + G + LH+A
Sbjct: 518 TR--GADVTLTDNEENICLHW-----ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 570
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A Y L+ A + + G TA L
Sbjct: 571 ARESYHDCVLLFLSRGANPELRNKEGDTAWDL 602
>BX005460-5|CAM26151.1| 888|Homo sapiens euchromatic histone-lysine
N-methyltransferase 2 protein.
Length = 888
Score = 105 bits (251), Expect = 2e-21
Identities = 82/277 (29%), Positives = 133/277 (48%), Gaps = 6/277 (2%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH-NAMI 1022
SA+ L G + AL+ ++ K R L+L+ G V ++ D+ +
Sbjct: 297 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 356
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++
Sbjct: 357 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YM 415
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
Q V + +DG+TC H AA G+++++ L+ + V +A++ TP+ AAE
Sbjct: 416 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQDS-GGWTPIIWAAEH 473
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
H +V+R+L+ GA T + +H A+ G + +V+ + + G TPL
Sbjct: 474 KHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPL 533
Query: 1203 HIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
HIAA + V LS P E T L P
Sbjct: 534 HIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 570
Score = 91.1 bits (216), Expect = 4e-17
Identities = 65/213 (30%), Positives = 108/213 (50%), Gaps = 6/213 (2%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 364 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 422
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
T LH AA G +E+ LLL G +++A D G PI AA++ + EV+++
Sbjct: 423 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 482
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L + ++ + T + N C H A+ GS + E L+ + + A N D TPL +AA
Sbjct: 483 LTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGD-TPLHIAAR 538
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ D V + + GA+ N+ G TA L E
Sbjct: 539 ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 571
Score = 81.4 bits (192), Expect = 3e-14
Identities = 76/249 (30%), Positives = 113/249 (45%), Gaps = 18/249 (7%)
Query: 1101 HIAAIQGSV-KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
+++ QG + KVI LM D ++ + TPL AA+ G ++ VL++AGA+
Sbjct: 333 YLSVKQGELQKVI--LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 390
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
++ T + A + H V M S ++ G T LH AA G E V LLS
Sbjct: 391 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 450
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G V A G TP+ AA + + V+R+LL + G NE
Sbjct: 451 --TGQVDVNAQDS----------GGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEEN 497
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
LH A F G +I +LL+ +L H+ + HG T LHIA+ ++ V + L +GA
Sbjct: 498 IC-LHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 555
Query: 1340 NATDKNGWT 1348
+K G T
Sbjct: 556 ELRNKEGDT 564
Score = 79.4 bits (187), Expect = 1e-13
Identities = 50/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+S TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 361 QSKRTPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQR 418
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLN 1360
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+ AA+ H+
Sbjct: 419 GG-CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIE 477
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
V+++L GA N + +A+ + E LL+ D ++
Sbjct: 478 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 525
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/207 (30%), Positives = 96/207 (46%), Gaps = 15/207 (7%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 365 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 423
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
S+ E G T LH AA GN +V LLL++ V +A + G+ P+ A
Sbjct: 424 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA-QDSGGWTPIIWA 470
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
H+ ++ +LL+R A++ TD LH AS G + EVLL +++A + +G
Sbjct: 471 AEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 529
Query: 1347 WTPLHCAAKAGHLNVVKLLCESGASPK 1373
TPLH AA+ + + V L GA+P+
Sbjct: 530 DTPLHIAARESYHDCVLLFLSRGANPE 556
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL A +G +++ + LL A ++ D + R+ L A + +L+V ++ + S
Sbjct: 365 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 424
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K +G T LH AA G +V L+ ++ TP+ AA IEV ++LL
Sbjct: 425 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 484
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
GA++ TD +H A+ + + ++ L +L A G+T HIAA +
Sbjct: 485 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHD 543
Query: 1111 VIEELMKFDRTGVISARNKLNDS 1133
+ L+ R RNK D+
Sbjct: 544 CV--LLFLSRGANPELRNKEGDT 564
Score = 69.3 bits (162), Expect = 1e-10
Identities = 67/253 (26%), Positives = 117/253 (46%), Gaps = 31/253 (12%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++++ K G L ++L+L D DP ++ D + TPL A + +I L++
Sbjct: 332 LYLSVKQGELQKVILMLLDNLDPNFQS-----DQQSKRTPLHAAAQKGSVEICHVLLQ-- 384
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A I+AVD+ + L A + +V + +++ G V
Sbjct: 385 --------AGANINAVDKQQRTPLMEA---------VVNNHLEVARYMVQRGGCV-YSKE 426
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
+ T H+ A GN ++++ ++ ST V +N Q+S GWTP++ A H++++
Sbjct: 427 EDGSTCLHHAAKIGNLEMVSLLL---STGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRM 481
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY 1007
LLT A V + D E LH A+ G + + LL + +++ +G T LH+AA Y
Sbjct: 482 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 541
Query: 1008 AHLV-KFLIRDHN 1019
V FL R N
Sbjct: 542 HDCVLLFLSRGAN 554
Score = 67.7 bits (158), Expect = 4e-10
Identities = 46/172 (26%), Positives = 84/172 (48%), Gaps = 4/172 (2%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 392 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 449
Query: 119 DYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
G V V+A + G TP+ AA +++ A+ + DNE+ +H A+ G A
Sbjct: 450 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 509
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
AI E+L + + + G T +HIA+ + DC ++ +G + NK
Sbjct: 510 AIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 560
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 470 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 528
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 529 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 587
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 588 GVGNRAIRTEKIICRDVARGYENVPIPC 615
Score = 64.1 bits (149), Expect = 5e-09
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 16/200 (8%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 365 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 411
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
R ++ G + E+G LH A G++ +V LLLS +++ D G T +
Sbjct: 412 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 469
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLN 1379
A+ H H +++ +LL +GA++ TD LH A+ G + ++L + +
Sbjct: 470 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 529
Query: 1380 CAPIWFAASENHND-VLEYL 1398
P+ AA E+++D VL +L
Sbjct: 530 DTPLHIAARESYHDCVLLFL 549
Score = 52.4 bits (120), Expect = 2e-05
Identities = 46/192 (23%), Positives = 81/192 (42%), Gaps = 3/192 (1%)
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGK-TGLHIASTHGHYQMVEVLLGQGAEINA 1341
L+L+ G + V L+L + + +D+ K T LH A+ G ++ VLL GA INA
Sbjct: 332 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 391
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
DK TPL A HL V + + + G S+ + AA + +++ LL
Sbjct: 392 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 451
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKER 1461
+ D + ++ + H +I + +L A V NI ++ ++
Sbjct: 452 GQVDVNAQDSGG--WTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 509
Query: 1462 AKDLIAAGKQCE 1473
A + +C+
Sbjct: 510 AIAEVLLNARCD 521
Score = 50.0 bits (114), Expect = 9e-05
Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 2/156 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L L+V+ G V +L ++ + T LH AA++ V++ +L+ GA ++A
Sbjct: 332 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 391
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED-RTPMHLAAENGHAAIIELLAD 185
+ +TPL A + +Y R + ED T +H AA+ G+ ++ LL
Sbjct: 392 VDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 450
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + + G T + A+ + H + ML +G
Sbjct: 451 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 486
Score = 49.6 bits (113), Expect = 1e-04
Identities = 41/159 (25%), Positives = 68/159 (42%), Gaps = 4/159 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + GN MV LLS + + A G T + AA + +++ R+L+ GA
Sbjct: 429 GSTCLHHAAKIGNLEMVSLLLSTGQVD-VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGA 487
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
V T+ LH A+ G + + R + + TP+H+AA E+ H ++
Sbjct: 488 DVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 547
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L+ + R K+G T + A+ L +K
Sbjct: 548 FLSRGANPEL--RNKEGDTAWDLTPERSDVWFALQLNRK 584
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 367 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 426
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
+ T LH AA+I + + +L+L N G TP+ AA+ ++ + +LL
Sbjct: 427 -EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 485
Query: 787 GGD 789
G D
Sbjct: 486 GAD 488
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 365 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 422
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 423 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 452
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 463 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 520
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 521 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 580
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 581 LNRKLRLGVGNR 592
Score = 36.7 bits (81), Expect = 0.89
Identities = 63/272 (23%), Positives = 114/272 (41%), Gaps = 39/272 (14%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLATLVLLLEDGGDPL 791
L+++ + + K LMLL + PN ++ TP+H AA+ G++ +LL+ G +
Sbjct: 332 LYLSVKQGELQKVILMLLDN-LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 390
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
K TPL A + ++ R++++ +G V + +EDG++ L
Sbjct: 391 AVDK-------QQRTPLMEAVVNNHLEVARYMVQ-----RGGCVYSK-----EEDGSTCL 433
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENG-ADVSLQTRHNHETAFHYCAIAGNNDVMTEMI 910
H+A K+ + ++V L+ G DV+ Q T + A + +V+ ++
Sbjct: 434 HHAAKI---------GNLEMVSLLLSTGQVDVNAQDSGGW-TPIIWAAEHKHIEVIRMLL 483
Query: 911 AHISTADVSRALNRQN-SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
ADV+ N +N + W A G + LL + + G + LH+A
Sbjct: 484 TR--GADVTLTDNEENICLHW-----ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 536
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A Y L+ A + + G TA L
Sbjct: 537 ARESYHDCVLLFLSRGANPELRNKEGDTAWDL 568
>BC020970-1|AAH20970.2| 1198|Homo sapiens EHMT2 protein protein.
Length = 1198
Score = 105 bits (251), Expect = 2e-21
Identities = 82/277 (29%), Positives = 133/277 (48%), Gaps = 6/277 (2%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH-NAMI 1022
SA+ L G + AL+ ++ K R L+L+ G V ++ D+ +
Sbjct: 607 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 666
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++
Sbjct: 667 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YM 725
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
Q V + +DG+TC H AA G+++++ L+ + V +A++ TP+ AAE
Sbjct: 726 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQDS-GGWTPIIWAAEH 783
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
H +V+R+L+ GA T + +H A+ G + +V+ + + G TPL
Sbjct: 784 KHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPL 843
Query: 1203 HIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
HIAA + V LS P E T L P
Sbjct: 844 HIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 880
Score = 91.1 bits (216), Expect = 4e-17
Identities = 65/213 (30%), Positives = 108/213 (50%), Gaps = 6/213 (2%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 674 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 732
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
T LH AA G +E+ LLL G +++A D G PI AA++ + EV+++
Sbjct: 733 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 792
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L + ++ + T + N C H A+ GS + E L+ + + A N D TPL +AA
Sbjct: 793 LTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGD-TPLHIAAR 848
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ D V + + GA+ N+ G TA L E
Sbjct: 849 ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 881
Score = 81.4 bits (192), Expect = 3e-14
Identities = 76/249 (30%), Positives = 113/249 (45%), Gaps = 18/249 (7%)
Query: 1101 HIAAIQGSV-KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
+++ QG + KVI LM D ++ + TPL AA+ G ++ VL++AGA+
Sbjct: 643 YLSVKQGELQKVI--LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 700
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
++ T + A + H V M S ++ G T LH AA G E V LLS
Sbjct: 701 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 760
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G V A G TP+ AA + + V+R+LL + G NE
Sbjct: 761 --TGQVDVNAQDS----------GGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEEN 807
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
LH A F G +I +LL+ +L H+ + HG T LHIA+ ++ V + L +GA
Sbjct: 808 IC-LHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 865
Query: 1340 NATDKNGWT 1348
+K G T
Sbjct: 866 ELRNKEGDT 874
Score = 79.4 bits (187), Expect = 1e-13
Identities = 50/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+S TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 671 QSKRTPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQR 728
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLN 1360
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+ AA+ H+
Sbjct: 729 GG-CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIE 787
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
V+++L GA N + +A+ + E LL+ D ++
Sbjct: 788 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 835
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/207 (30%), Positives = 96/207 (46%), Gaps = 15/207 (7%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 675 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 733
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
S+ E G T LH AA GN +V LLL++ V +A + G+ P+ A
Sbjct: 734 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA-QDSGGWTPIIWA 780
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
H+ ++ +LL+R A++ TD LH AS G + EVLL +++A + +G
Sbjct: 781 AEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 839
Query: 1347 WTPLHCAAKAGHLNVVKLLCESGASPK 1373
TPLH AA+ + + V L GA+P+
Sbjct: 840 DTPLHIAARESYHDCVLLFLSRGANPE 866
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL A +G +++ + LL A ++ D + R+ L A + +L+V ++ + S
Sbjct: 675 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 734
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K +G T LH AA G +V L+ ++ TP+ AA IEV ++LL
Sbjct: 735 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 794
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
GA++ TD +H A+ + + ++ L +L A G+T HIAA +
Sbjct: 795 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHD 853
Query: 1111 VIEELMKFDRTGVISARNKLNDS 1133
+ L+ R RNK D+
Sbjct: 854 CV--LLFLSRGANPELRNKEGDT 874
Score = 69.3 bits (162), Expect = 1e-10
Identities = 67/253 (26%), Positives = 117/253 (46%), Gaps = 31/253 (12%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++++ K G L ++L+L D DP ++ D + TPL A + +I L++
Sbjct: 642 LYLSVKQGELQKVILMLLDNLDPNFQS-----DQQSKRTPLHAAAQKGSVEICHVLLQ-- 694
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A I+AVD+ + L A + +V + +++ G V
Sbjct: 695 --------AGANINAVDKQQRTPLMEA---------VVNNHLEVARYMVQRGGCV-YSKE 736
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
+ T H+ A GN ++++ ++ ST V +N Q+S GWTP++ A H++++
Sbjct: 737 EDGSTCLHHAAKIGNLEMVSLLL---STGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRM 791
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY 1007
LLT A V + D E LH A+ G + + LL + +++ +G T LH+AA Y
Sbjct: 792 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 851
Query: 1008 AHLV-KFLIRDHN 1019
V FL R N
Sbjct: 852 HDCVLLFLSRGAN 864
Score = 67.7 bits (158), Expect = 4e-10
Identities = 46/172 (26%), Positives = 84/172 (48%), Gaps = 4/172 (2%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 702 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 759
Query: 119 DYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
G V V+A + G TP+ AA +++ A+ + DNE+ +H A+ G A
Sbjct: 760 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 819
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
AI E+L + + + G T +HIA+ + DC ++ +G + NK
Sbjct: 820 AIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 870
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 780 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 838
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 839 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 897
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 898 GVGNRAIRTEKIICRDVARGYENVPIPC 925
Score = 64.1 bits (149), Expect = 5e-09
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 16/200 (8%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 675 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 721
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
R ++ G + E+G LH A G++ +V LLLS +++ D G T +
Sbjct: 722 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 779
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLN 1379
A+ H H +++ +LL +GA++ TD LH A+ G + ++L + +
Sbjct: 780 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 839
Query: 1380 CAPIWFAASENHND-VLEYL 1398
P+ AA E+++D VL +L
Sbjct: 840 DTPLHIAARESYHDCVLLFL 859
Score = 52.4 bits (120), Expect = 2e-05
Identities = 46/192 (23%), Positives = 81/192 (42%), Gaps = 3/192 (1%)
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGK-TGLHIASTHGHYQMVEVLLGQGAEINA 1341
L+L+ G + V L+L + + +D+ K T LH A+ G ++ VLL GA INA
Sbjct: 642 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 701
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
DK TPL A HL V + + + G S+ + AA + +++ LL
Sbjct: 702 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 761
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKER 1461
+ D + ++ + H +I + +L A V NI ++ ++
Sbjct: 762 GQVDVNAQDSGG--WTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 819
Query: 1462 AKDLIAAGKQCE 1473
A + +C+
Sbjct: 820 AIAEVLLNARCD 831
Score = 50.0 bits (114), Expect = 9e-05
Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 2/156 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L L+V+ G V +L ++ + T LH AA++ V++ +L+ GA ++A
Sbjct: 642 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 701
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED-RTPMHLAAENGHAAIIELLAD 185
+ +TPL A + +Y R + ED T +H AA+ G+ ++ LL
Sbjct: 702 VDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 760
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + + G T + A+ + H + ML +G
Sbjct: 761 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 796
Score = 49.6 bits (113), Expect = 1e-04
Identities = 41/159 (25%), Positives = 68/159 (42%), Gaps = 4/159 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + GN MV LLS + + A G T + AA + +++ R+L+ GA
Sbjct: 739 GSTCLHHAAKIGNLEMVSLLLSTGQVD-VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGA 797
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
V T+ LH A+ G + + R + + TP+H+AA E+ H ++
Sbjct: 798 DVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 857
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L+ + R K+G T + A+ L +K
Sbjct: 858 FLSRGANPEL--RNKEGDTAWDLTPERSDVWFALQLNRK 894
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 677 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 736
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
+ T LH AA+I + + +L+L N G TP+ AA+ ++ + +LL
Sbjct: 737 -EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 795
Query: 787 GGD 789
G D
Sbjct: 796 GAD 798
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 675 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 732
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 733 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 762
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 773 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 830
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 831 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 890
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 891 LNRKLRLGVGNR 902
Score = 36.7 bits (81), Expect = 0.89
Identities = 63/272 (23%), Positives = 114/272 (41%), Gaps = 39/272 (14%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLATLVLLLEDGGDPL 791
L+++ + + K LMLL + PN ++ TP+H AA+ G++ +LL+ G +
Sbjct: 642 LYLSVKQGELQKVILMLLDN-LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 700
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
K TPL A + ++ R++++ +G V + +EDG++ L
Sbjct: 701 AVDK-------QQRTPLMEAVVNNHLEVARYMVQ-----RGGCVYSK-----EEDGSTCL 743
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENG-ADVSLQTRHNHETAFHYCAIAGNNDVMTEMI 910
H+A K+ + ++V L+ G DV+ Q T + A + +V+ ++
Sbjct: 744 HHAAKI---------GNLEMVSLLLSTGQVDVNAQDSGGW-TPIIWAAEHKHIEVIRMLL 793
Query: 911 AHISTADVSRALNRQN-SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
ADV+ N +N + W A G + LL + + G + LH+A
Sbjct: 794 TR--GADVTLTDNEENICLHW-----ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 846
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A Y L+ A + + G TA L
Sbjct: 847 ARESYHDCVLLFLSRGANPELRNKEGDTAWDL 878
>BC018718-1|AAH18718.1| 1001|Homo sapiens EHMT2 protein protein.
Length = 1001
Score = 105 bits (251), Expect = 2e-21
Identities = 82/277 (29%), Positives = 133/277 (48%), Gaps = 6/277 (2%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH-NAMI 1022
SA+ L G + AL+ ++ K R L+L+ G V ++ D+ +
Sbjct: 410 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 469
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++
Sbjct: 470 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YM 528
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
Q V + +DG+TC H AA G+++++ L+ + V +A++ TP+ AAE
Sbjct: 529 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQDS-GGWTPIIWAAEH 586
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
H +V+R+L+ GA T + +H A+ G + +V+ + + G TPL
Sbjct: 587 KHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPL 646
Query: 1203 HIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
HIAA + V LS P E T L P
Sbjct: 647 HIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 683
Score = 91.1 bits (216), Expect = 4e-17
Identities = 65/213 (30%), Positives = 108/213 (50%), Gaps = 6/213 (2%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 477 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 535
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
T LH AA G +E+ LLL G +++A D G PI AA++ + EV+++
Sbjct: 536 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 595
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L + ++ + T + N C H A+ GS + E L+ + + A N D TPL +AA
Sbjct: 596 LTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGD-TPLHIAAR 651
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ D V + + GA+ N+ G TA L E
Sbjct: 652 ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 684
Score = 81.4 bits (192), Expect = 3e-14
Identities = 76/249 (30%), Positives = 113/249 (45%), Gaps = 18/249 (7%)
Query: 1101 HIAAIQGSV-KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
+++ QG + KVI LM D ++ + TPL AA+ G ++ VL++AGA+
Sbjct: 446 YLSVKQGELQKVI--LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 503
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
++ T + A + H V M S ++ G T LH AA G E V LLS
Sbjct: 504 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 563
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G V A G TP+ AA + + V+R+LL + G NE
Sbjct: 564 --TGQVDVNAQDS----------GGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEEN 610
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
LH A F G +I +LL+ +L H+ + HG T LHIA+ ++ V + L +GA
Sbjct: 611 IC-LHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 668
Query: 1340 NATDKNGWT 1348
+K G T
Sbjct: 669 ELRNKEGDT 677
Score = 79.4 bits (187), Expect = 1e-13
Identities = 50/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+S TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 474 QSKRTPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQR 531
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLN 1360
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+ AA+ H+
Sbjct: 532 GG-CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIE 590
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
V+++L GA N + +A+ + E LL+ D ++
Sbjct: 591 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 638
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/207 (30%), Positives = 96/207 (46%), Gaps = 15/207 (7%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 478 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 536
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
S+ E G T LH AA GN +V LLL++ V +A + G+ P+ A
Sbjct: 537 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA-QDSGGWTPIIWA 583
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
H+ ++ +LL+R A++ TD LH AS G + EVLL +++A + +G
Sbjct: 584 AEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 642
Query: 1347 WTPLHCAAKAGHLNVVKLLCESGASPK 1373
TPLH AA+ + + V L GA+P+
Sbjct: 643 DTPLHIAARESYHDCVLLFLSRGANPE 669
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL A +G +++ + LL A ++ D + R+ L A + +L+V ++ + S
Sbjct: 478 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 537
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K +G T LH AA G +V L+ ++ TP+ AA IEV ++LL
Sbjct: 538 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 597
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
GA++ TD +H A+ + + ++ L +L A G+T HIAA +
Sbjct: 598 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHD 656
Query: 1111 VIEELMKFDRTGVISARNKLNDS 1133
+ L+ R RNK D+
Sbjct: 657 CV--LLFLSRGANPELRNKEGDT 677
Score = 69.3 bits (162), Expect = 1e-10
Identities = 67/253 (26%), Positives = 117/253 (46%), Gaps = 31/253 (12%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++++ K G L ++L+L D DP ++ D + TPL A + +I L++
Sbjct: 445 LYLSVKQGELQKVILMLLDNLDPNFQS-----DQQSKRTPLHAAAQKGSVEICHVLLQ-- 497
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A I+AVD+ + L A + +V + +++ G V
Sbjct: 498 --------AGANINAVDKQQRTPLMEA---------VVNNHLEVARYMVQRGGCV-YSKE 539
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
+ T H+ A GN ++++ ++ ST V +N Q+S GWTP++ A H++++
Sbjct: 540 EDGSTCLHHAAKIGNLEMVSLLL---STGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRM 594
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY 1007
LLT A V + D E LH A+ G + + LL + +++ +G T LH+AA Y
Sbjct: 595 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 654
Query: 1008 AHLV-KFLIRDHN 1019
V FL R N
Sbjct: 655 HDCVLLFLSRGAN 667
Score = 67.7 bits (158), Expect = 4e-10
Identities = 46/172 (26%), Positives = 84/172 (48%), Gaps = 4/172 (2%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 505 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 562
Query: 119 DYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
G V V+A + G TP+ AA +++ A+ + DNE+ +H A+ G A
Sbjct: 563 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 622
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
AI E+L + + + G T +HIA+ + DC ++ +G + NK
Sbjct: 623 AIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 673
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 583 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 641
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 642 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 700
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 701 GVGNRAIRTEKIICRDVARGYENVPIPC 728
Score = 64.1 bits (149), Expect = 5e-09
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 16/200 (8%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 478 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 524
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
R ++ G + E+G LH A G++ +V LLLS +++ D G T +
Sbjct: 525 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 582
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLN 1379
A+ H H +++ +LL +GA++ TD LH A+ G + ++L + +
Sbjct: 583 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 642
Query: 1380 CAPIWFAASENHND-VLEYL 1398
P+ AA E+++D VL +L
Sbjct: 643 DTPLHIAARESYHDCVLLFL 662
Score = 52.4 bits (120), Expect = 2e-05
Identities = 46/192 (23%), Positives = 81/192 (42%), Gaps = 3/192 (1%)
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGK-TGLHIASTHGHYQMVEVLLGQGAEINA 1341
L+L+ G + V L+L + + +D+ K T LH A+ G ++ VLL GA INA
Sbjct: 445 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 504
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
DK TPL A HL V + + + G S+ + AA + +++ LL
Sbjct: 505 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 564
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKER 1461
+ D + ++ + H +I + +L A V NI ++ ++
Sbjct: 565 GQVDVNAQDSGG--WTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 622
Query: 1462 AKDLIAAGKQCE 1473
A + +C+
Sbjct: 623 AIAEVLLNARCD 634
Score = 50.0 bits (114), Expect = 9e-05
Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 2/156 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L L+V+ G V +L ++ + T LH AA++ V++ +L+ GA ++A
Sbjct: 445 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 504
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED-RTPMHLAAENGHAAIIELLAD 185
+ +TPL A + +Y R + ED T +H AA+ G+ ++ LL
Sbjct: 505 VDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 563
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + + G T + A+ + H + ML +G
Sbjct: 564 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 599
Score = 49.6 bits (113), Expect = 1e-04
Identities = 41/159 (25%), Positives = 68/159 (42%), Gaps = 4/159 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + GN MV LLS + + A G T + AA + +++ R+L+ GA
Sbjct: 542 GSTCLHHAAKIGNLEMVSLLLSTGQVD-VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGA 600
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
V T+ LH A+ G + + R + + TP+H+AA E+ H ++
Sbjct: 601 DVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 660
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L+ + R K+G T + A+ L +K
Sbjct: 661 FLSRGANPEL--RNKEGDTAWDLTPERSDVWFALQLNRK 697
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 480 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 539
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
+ T LH AA+I + + +L+L N G TP+ AA+ ++ + +LL
Sbjct: 540 -EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 598
Query: 787 GGD 789
G D
Sbjct: 599 GAD 601
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 478 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 535
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 536 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 565
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 576 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 633
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 634 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 693
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 694 LNRKLRLGVGNR 705
Score = 36.7 bits (81), Expect = 0.89
Identities = 63/272 (23%), Positives = 114/272 (41%), Gaps = 39/272 (14%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLATLVLLLEDGGDPL 791
L+++ + + K LMLL + PN ++ TP+H AA+ G++ +LL+ G +
Sbjct: 445 LYLSVKQGELQKVILMLLDN-LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 503
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
K TPL A + ++ R++++ +G V + +EDG++ L
Sbjct: 504 AVDK-------QQRTPLMEAVVNNHLEVARYMVQ-----RGGCVYSK-----EEDGSTCL 546
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENG-ADVSLQTRHNHETAFHYCAIAGNNDVMTEMI 910
H+A K+ + ++V L+ G DV+ Q T + A + +V+ ++
Sbjct: 547 HHAAKI---------GNLEMVSLLLSTGQVDVNAQDSGGW-TPIIWAAEHKHIEVIRMLL 596
Query: 911 AHISTADVSRALNRQN-SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
ADV+ N +N + W A G + LL + + G + LH+A
Sbjct: 597 TR--GADVTLTDNEENICLHW-----ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 649
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A Y L+ A + + G TA L
Sbjct: 650 ARESYHDCVLLFLSRGANPELRNKEGDTAWDL 681
>BC009351-1|AAH09351.1| 1209|Homo sapiens EHMT2 protein protein.
Length = 1209
Score = 105 bits (251), Expect = 2e-21
Identities = 82/277 (29%), Positives = 133/277 (48%), Gaps = 6/277 (2%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH-NAMI 1022
SA+ L G + AL+ ++ K R L+L+ G V ++ D+ +
Sbjct: 618 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 677
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++
Sbjct: 678 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YM 736
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
Q V + +DG+TC H AA G+++++ L+ + V +A++ TP+ AAE
Sbjct: 737 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQDS-GGWTPIIWAAEH 794
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
H +V+R+L+ GA T + +H A+ G + +V+ + + G TPL
Sbjct: 795 KHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPL 854
Query: 1203 HIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
HIAA + V LS P E T L P
Sbjct: 855 HIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 891
Score = 91.1 bits (216), Expect = 4e-17
Identities = 65/213 (30%), Positives = 108/213 (50%), Gaps = 6/213 (2%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 685 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 743
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
T LH AA G +E+ LLL G +++A D G PI AA++ + EV+++
Sbjct: 744 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 803
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L + ++ + T + N C H A+ GS + E L+ + + A N D TPL +AA
Sbjct: 804 LTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGD-TPLHIAAR 859
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ D V + + GA+ N+ G TA L E
Sbjct: 860 ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 892
Score = 81.4 bits (192), Expect = 3e-14
Identities = 76/249 (30%), Positives = 113/249 (45%), Gaps = 18/249 (7%)
Query: 1101 HIAAIQGSV-KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
+++ QG + KVI LM D ++ + TPL AA+ G ++ VL++AGA+
Sbjct: 654 YLSVKQGELQKVI--LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 711
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
++ T + A + H V M S ++ G T LH AA G E V LLS
Sbjct: 712 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 771
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G V A G TP+ AA + + V+R+LL + G NE
Sbjct: 772 --TGQVDVNAQDS----------GGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEEN 818
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
LH A F G +I +LL+ +L H+ + HG T LHIA+ ++ V + L +GA
Sbjct: 819 IC-LHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 876
Query: 1340 NATDKNGWT 1348
+K G T
Sbjct: 877 ELRNKEGDT 885
Score = 79.4 bits (187), Expect = 1e-13
Identities = 50/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+S TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 682 QSKRTPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQR 739
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLN 1360
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+ AA+ H+
Sbjct: 740 GG-CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIE 798
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
V+++L GA N + +A+ + E LL+ D ++
Sbjct: 799 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 846
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/207 (30%), Positives = 96/207 (46%), Gaps = 15/207 (7%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 686 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 744
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
S+ E G T LH AA GN +V LLL++ V +A + G+ P+ A
Sbjct: 745 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA-QDSGGWTPIIWA 791
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
H+ ++ +LL+R A++ TD LH AS G + EVLL +++A + +G
Sbjct: 792 AEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 850
Query: 1347 WTPLHCAAKAGHLNVVKLLCESGASPK 1373
TPLH AA+ + + V L GA+P+
Sbjct: 851 DTPLHIAARESYHDCVLLFLSRGANPE 877
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL A +G +++ + LL A ++ D + R+ L A + +L+V ++ + S
Sbjct: 686 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 745
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K +G T LH AA G +V L+ ++ TP+ AA IEV ++LL
Sbjct: 746 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 805
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
GA++ TD +H A+ + + ++ L +L A G+T HIAA +
Sbjct: 806 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHD 864
Query: 1111 VIEELMKFDRTGVISARNKLNDS 1133
+ L+ R RNK D+
Sbjct: 865 CV--LLFLSRGANPELRNKEGDT 885
Score = 69.3 bits (162), Expect = 1e-10
Identities = 67/253 (26%), Positives = 117/253 (46%), Gaps = 31/253 (12%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++++ K G L ++L+L D DP ++ D + TPL A + +I L++
Sbjct: 653 LYLSVKQGELQKVILMLLDNLDPNFQS-----DQQSKRTPLHAAAQKGSVEICHVLLQ-- 705
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A I+AVD+ + L A + +V + +++ G V
Sbjct: 706 --------AGANINAVDKQQRTPLMEA---------VVNNHLEVARYMVQRGGCV-YSKE 747
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
+ T H+ A GN ++++ ++ ST V +N Q+S GWTP++ A H++++
Sbjct: 748 EDGSTCLHHAAKIGNLEMVSLLL---STGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRM 802
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY 1007
LLT A V + D E LH A+ G + + LL + +++ +G T LH+AA Y
Sbjct: 803 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 862
Query: 1008 AHLV-KFLIRDHN 1019
V FL R N
Sbjct: 863 HDCVLLFLSRGAN 875
Score = 67.7 bits (158), Expect = 4e-10
Identities = 46/172 (26%), Positives = 84/172 (48%), Gaps = 4/172 (2%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 713 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 770
Query: 119 DYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
G V V+A + G TP+ AA +++ A+ + DNE+ +H A+ G A
Sbjct: 771 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 830
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
AI E+L + + + G T +HIA+ + DC ++ +G + NK
Sbjct: 831 AIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 881
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 791 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 849
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 850 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 908
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 909 GVGNRAIRTEKIICRDVARGYENVPIPC 936
Score = 64.1 bits (149), Expect = 5e-09
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 16/200 (8%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 686 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 732
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
R ++ G + E+G LH A G++ +V LLLS +++ D G T +
Sbjct: 733 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 790
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLN 1379
A+ H H +++ +LL +GA++ TD LH A+ G + ++L + +
Sbjct: 791 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 850
Query: 1380 CAPIWFAASENHND-VLEYL 1398
P+ AA E+++D VL +L
Sbjct: 851 DTPLHIAARESYHDCVLLFL 870
Score = 52.4 bits (120), Expect = 2e-05
Identities = 46/192 (23%), Positives = 81/192 (42%), Gaps = 3/192 (1%)
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGK-TGLHIASTHGHYQMVEVLLGQGAEINA 1341
L+L+ G + V L+L + + +D+ K T LH A+ G ++ VLL GA INA
Sbjct: 653 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 712
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
DK TPL A HL V + + + G S+ + AA + +++ LL
Sbjct: 713 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 772
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKER 1461
+ D + ++ + H +I + +L A V NI ++ ++
Sbjct: 773 GQVDVNAQDSGG--WTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 830
Query: 1462 AKDLIAAGKQCE 1473
A + +C+
Sbjct: 831 AIAEVLLNARCD 842
Score = 50.0 bits (114), Expect = 9e-05
Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 2/156 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L L+V+ G V +L ++ + T LH AA++ V++ +L+ GA ++A
Sbjct: 653 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 712
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED-RTPMHLAAENGHAAIIELLAD 185
+ +TPL A + +Y R + ED T +H AA+ G+ ++ LL
Sbjct: 713 VDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 771
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + + G T + A+ + H + ML +G
Sbjct: 772 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 807
Score = 49.6 bits (113), Expect = 1e-04
Identities = 41/159 (25%), Positives = 68/159 (42%), Gaps = 4/159 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + GN MV LLS + + A G T + AA + +++ R+L+ GA
Sbjct: 750 GSTCLHHAAKIGNLEMVSLLLSTGQVD-VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGA 808
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
V T+ LH A+ G + + R + + TP+H+AA E+ H ++
Sbjct: 809 DVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 868
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L+ + R K+G T + A+ L +K
Sbjct: 869 FLSRGANPEL--RNKEGDTAWDLTPERSDVWFALQLNRK 905
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 688 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 747
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
+ T LH AA+I + + +L+L N G TP+ AA+ ++ + +LL
Sbjct: 748 -EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 806
Query: 787 GGD 789
G D
Sbjct: 807 GAD 809
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 686 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 743
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 744 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 773
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 784 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 841
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 842 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 901
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 902 LNRKLRLGVGNR 913
Score = 36.7 bits (81), Expect = 0.89
Identities = 63/272 (23%), Positives = 114/272 (41%), Gaps = 39/272 (14%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLATLVLLLEDGGDPL 791
L+++ + + K LMLL + PN ++ TP+H AA+ G++ +LL+ G +
Sbjct: 653 LYLSVKQGELQKVILMLLDN-LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 711
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
K TPL A + ++ R++++ +G V + +EDG++ L
Sbjct: 712 AVDK-------QQRTPLMEAVVNNHLEVARYMVQ-----RGGCVYSK-----EEDGSTCL 754
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENG-ADVSLQTRHNHETAFHYCAIAGNNDVMTEMI 910
H+A K+ + ++V L+ G DV+ Q T + A + +V+ ++
Sbjct: 755 HHAAKI---------GNLEMVSLLLSTGQVDVNAQDSGGW-TPIIWAAEHKHIEVIRMLL 804
Query: 911 AHISTADVSRALNRQN-SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
ADV+ N +N + W A G + LL + + G + LH+A
Sbjct: 805 TR--GADVTLTDNEENICLHW-----ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 857
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A Y L+ A + + G TA L
Sbjct: 858 ARESYHDCVLLFLSRGANPELRNKEGDTAWDL 889
>BC002686-1|AAH02686.2| 1043|Homo sapiens EHMT2 protein protein.
Length = 1043
Score = 105 bits (251), Expect = 2e-21
Identities = 82/277 (29%), Positives = 133/277 (48%), Gaps = 6/277 (2%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH-NAMI 1022
SA+ L G + AL+ ++ K R L+L+ G V ++ D+ +
Sbjct: 452 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 511
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++
Sbjct: 512 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YM 570
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
Q V + +DG+TC H AA G+++++ L+ + V +A++ TP+ AAE
Sbjct: 571 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQDS-GGWTPIIWAAEH 628
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
H +V+R+L+ GA T + +H A+ G + +V+ + + G TPL
Sbjct: 629 KHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPL 688
Query: 1203 HIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
HIAA + V LS P E T L P
Sbjct: 689 HIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 725
Score = 91.1 bits (216), Expect = 4e-17
Identities = 65/213 (30%), Positives = 108/213 (50%), Gaps = 6/213 (2%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 519 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 577
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
T LH AA G +E+ LLL G +++A D G PI AA++ + EV+++
Sbjct: 578 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 637
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L + ++ + T + N C H A+ GS + E L+ + + A N D TPL +AA
Sbjct: 638 LTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGD-TPLHIAAR 693
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ D V + + GA+ N+ G TA L E
Sbjct: 694 ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 726
Score = 81.4 bits (192), Expect = 3e-14
Identities = 76/249 (30%), Positives = 113/249 (45%), Gaps = 18/249 (7%)
Query: 1101 HIAAIQGSV-KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
+++ QG + KVI LM D ++ + TPL AA+ G ++ VL++AGA+
Sbjct: 488 YLSVKQGELQKVI--LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 545
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
++ T + A + H V M S ++ G T LH AA G E V LLS
Sbjct: 546 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 605
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G V A G TP+ AA + + V+R+LL + G NE
Sbjct: 606 --TGQVDVNAQDS----------GGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEEN 652
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
LH A F G +I +LL+ +L H+ + HG T LHIA+ ++ V + L +GA
Sbjct: 653 IC-LHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 710
Query: 1340 NATDKNGWT 1348
+K G T
Sbjct: 711 ELRNKEGDT 719
Score = 79.4 bits (187), Expect = 1e-13
Identities = 50/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+S TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 516 QSKRTPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQR 573
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLN 1360
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+ AA+ H+
Sbjct: 574 GG-CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIE 632
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
V+++L GA N + +A+ + E LL+ D ++
Sbjct: 633 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 680
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/207 (30%), Positives = 96/207 (46%), Gaps = 15/207 (7%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 520 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 578
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
S+ E G T LH AA GN +V LLL++ V +A + G+ P+ A
Sbjct: 579 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA-QDSGGWTPIIWA 625
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
H+ ++ +LL+R A++ TD LH AS G + EVLL +++A + +G
Sbjct: 626 AEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 684
Query: 1347 WTPLHCAAKAGHLNVVKLLCESGASPK 1373
TPLH AA+ + + V L GA+P+
Sbjct: 685 DTPLHIAARESYHDCVLLFLSRGANPE 711
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL A +G +++ + LL A ++ D + R+ L A + +L+V ++ + S
Sbjct: 520 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 579
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K +G T LH AA G +V L+ ++ TP+ AA IEV ++LL
Sbjct: 580 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 639
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
GA++ TD +H A+ + + ++ L +L A G+T HIAA +
Sbjct: 640 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHD 698
Query: 1111 VIEELMKFDRTGVISARNKLNDS 1133
+ L+ R RNK D+
Sbjct: 699 CV--LLFLSRGANPELRNKEGDT 719
Score = 69.3 bits (162), Expect = 1e-10
Identities = 67/253 (26%), Positives = 117/253 (46%), Gaps = 31/253 (12%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++++ K G L ++L+L D DP ++ D + TPL A + +I L++
Sbjct: 487 LYLSVKQGELQKVILMLLDNLDPNFQS-----DQQSKRTPLHAAAQKGSVEICHVLLQ-- 539
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A I+AVD+ + L A + +V + +++ G V
Sbjct: 540 --------AGANINAVDKQQRTPLMEA---------VVNNHLEVARYMVQRGGCV-YSKE 581
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
+ T H+ A GN ++++ ++ ST V +N Q+S GWTP++ A H++++
Sbjct: 582 EDGSTCLHHAAKIGNLEMVSLLL---STGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRM 636
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY 1007
LLT A V + D E LH A+ G + + LL + +++ +G T LH+AA Y
Sbjct: 637 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 696
Query: 1008 AHLV-KFLIRDHN 1019
V FL R N
Sbjct: 697 HDCVLLFLSRGAN 709
Score = 67.7 bits (158), Expect = 4e-10
Identities = 46/172 (26%), Positives = 84/172 (48%), Gaps = 4/172 (2%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 547 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 604
Query: 119 DYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
G V V+A + G TP+ AA +++ A+ + DNE+ +H A+ G A
Sbjct: 605 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 664
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
AI E+L + + + G T +HIA+ + DC ++ +G + NK
Sbjct: 665 AIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 715
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 625 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 683
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 684 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 742
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 743 GVGNRAIRTEKIICRDVARGYENVPIPC 770
Score = 64.1 bits (149), Expect = 5e-09
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 16/200 (8%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 520 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 566
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
R ++ G + E+G LH A G++ +V LLLS +++ D G T +
Sbjct: 567 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 624
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLN 1379
A+ H H +++ +LL +GA++ TD LH A+ G + ++L + +
Sbjct: 625 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 684
Query: 1380 CAPIWFAASENHND-VLEYL 1398
P+ AA E+++D VL +L
Sbjct: 685 DTPLHIAARESYHDCVLLFL 704
Score = 52.4 bits (120), Expect = 2e-05
Identities = 46/192 (23%), Positives = 81/192 (42%), Gaps = 3/192 (1%)
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGK-TGLHIASTHGHYQMVEVLLGQGAEINA 1341
L+L+ G + V L+L + + +D+ K T LH A+ G ++ VLL GA INA
Sbjct: 487 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 546
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
DK TPL A HL V + + + G S+ + AA + +++ LL
Sbjct: 547 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 606
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKER 1461
+ D + ++ + H +I + +L A V NI ++ ++
Sbjct: 607 GQVDVNAQDSGG--WTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 664
Query: 1462 AKDLIAAGKQCE 1473
A + +C+
Sbjct: 665 AIAEVLLNARCD 676
Score = 50.0 bits (114), Expect = 9e-05
Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 2/156 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L L+V+ G V +L ++ + T LH AA++ V++ +L+ GA ++A
Sbjct: 487 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 546
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED-RTPMHLAAENGHAAIIELLAD 185
+ +TPL A + +Y R + ED T +H AA+ G+ ++ LL
Sbjct: 547 VDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 605
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + + G T + A+ + H + ML +G
Sbjct: 606 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 641
Score = 49.6 bits (113), Expect = 1e-04
Identities = 41/159 (25%), Positives = 68/159 (42%), Gaps = 4/159 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + GN MV LLS + + A G T + AA + +++ R+L+ GA
Sbjct: 584 GSTCLHHAAKIGNLEMVSLLLSTGQVD-VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGA 642
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
V T+ LH A+ G + + R + + TP+H+AA E+ H ++
Sbjct: 643 DVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 702
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L+ + R K+G T + A+ L +K
Sbjct: 703 FLSRGANPEL--RNKEGDTAWDLTPERSDVWFALQLNRK 739
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 522 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 581
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
+ T LH AA+I + + +L+L N G TP+ AA+ ++ + +LL
Sbjct: 582 -EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 640
Query: 787 GGD 789
G D
Sbjct: 641 GAD 643
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 520 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 577
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 578 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 607
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 618 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 675
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 676 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 735
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 736 LNRKLRLGVGNR 747
Score = 36.7 bits (81), Expect = 0.89
Identities = 63/272 (23%), Positives = 114/272 (41%), Gaps = 39/272 (14%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLATLVLLLEDGGDPL 791
L+++ + + K LMLL + PN ++ TP+H AA+ G++ +LL+ G +
Sbjct: 487 LYLSVKQGELQKVILMLLDN-LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 545
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
K TPL A + ++ R++++ +G V + +EDG++ L
Sbjct: 546 AVDK-------QQRTPLMEAVVNNHLEVARYMVQ-----RGGCVYSK-----EEDGSTCL 588
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENG-ADVSLQTRHNHETAFHYCAIAGNNDVMTEMI 910
H+A K+ + ++V L+ G DV+ Q T + A + +V+ ++
Sbjct: 589 HHAAKI---------GNLEMVSLLLSTGQVDVNAQDSGGW-TPIIWAAEHKHIEVIRMLL 638
Query: 911 AHISTADVSRALNRQN-SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
ADV+ N +N + W A G + LL + + G + LH+A
Sbjct: 639 TR--GADVTLTDNEENICLHW-----ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 691
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A Y L+ A + + G TA L
Sbjct: 692 ARESYHDCVLLFLSRGANPELRNKEGDTAWDL 723
>BA000025-4|BAB63295.1| 1001|Homo sapiens G9A protein.
Length = 1001
Score = 105 bits (251), Expect = 2e-21
Identities = 82/277 (29%), Positives = 133/277 (48%), Gaps = 6/277 (2%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH-NAMI 1022
SA+ L G + AL+ ++ K R L+L+ G V ++ D+ +
Sbjct: 410 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 469
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++
Sbjct: 470 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YM 528
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
Q V + +DG+TC H AA G+++++ L+ + V +A++ TP+ AAE
Sbjct: 529 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQDS-GGWTPIIWAAEH 586
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
H +V+R+L+ GA T + +H A+ G + +V+ + + G TPL
Sbjct: 587 KHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPL 646
Query: 1203 HIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
HIAA + V LS P E T L P
Sbjct: 647 HIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 683
Score = 91.1 bits (216), Expect = 4e-17
Identities = 65/213 (30%), Positives = 108/213 (50%), Gaps = 6/213 (2%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 477 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 535
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
T LH AA G +E+ LLL G +++A D G PI AA++ + EV+++
Sbjct: 536 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 595
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L + ++ + T + N C H A+ GS + E L+ + + A N D TPL +AA
Sbjct: 596 LTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGD-TPLHIAAR 651
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ D V + + GA+ N+ G TA L E
Sbjct: 652 ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 684
Score = 81.4 bits (192), Expect = 3e-14
Identities = 76/249 (30%), Positives = 113/249 (45%), Gaps = 18/249 (7%)
Query: 1101 HIAAIQGSV-KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
+++ QG + KVI LM D ++ + TPL AA+ G ++ VL++AGA+
Sbjct: 446 YLSVKQGELQKVI--LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 503
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
++ T + A + H V M S ++ G T LH AA G E V LLS
Sbjct: 504 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 563
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G V A G TP+ AA + + V+R+LL + G NE
Sbjct: 564 --TGQVDVNAQDS----------GGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEEN 610
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
LH A F G +I +LL+ +L H+ + HG T LHIA+ ++ V + L +GA
Sbjct: 611 IC-LHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 668
Query: 1340 NATDKNGWT 1348
+K G T
Sbjct: 669 ELRNKEGDT 677
Score = 79.4 bits (187), Expect = 1e-13
Identities = 50/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+S TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 474 QSKRTPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQR 531
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLN 1360
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+ AA+ H+
Sbjct: 532 GG-CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIE 590
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
V+++L GA N + +A+ + E LL+ D ++
Sbjct: 591 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 638
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/207 (30%), Positives = 96/207 (46%), Gaps = 15/207 (7%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 478 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 536
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
S+ E G T LH AA GN +V LLL++ V +A + G+ P+ A
Sbjct: 537 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA-QDSGGWTPIIWA 583
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
H+ ++ +LL+R A++ TD LH AS G + EVLL +++A + +G
Sbjct: 584 AEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 642
Query: 1347 WTPLHCAAKAGHLNVVKLLCESGASPK 1373
TPLH AA+ + + V L GA+P+
Sbjct: 643 DTPLHIAARESYHDCVLLFLSRGANPE 669
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL A +G +++ + LL A ++ D + R+ L A + +L+V ++ + S
Sbjct: 478 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 537
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K +G T LH AA G +V L+ ++ TP+ AA IEV ++LL
Sbjct: 538 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 597
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
GA++ TD +H A+ + + ++ L +L A G+T HIAA +
Sbjct: 598 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHD 656
Query: 1111 VIEELMKFDRTGVISARNKLNDS 1133
+ L+ R RNK D+
Sbjct: 657 CV--LLFLSRGANPELRNKEGDT 677
Score = 69.3 bits (162), Expect = 1e-10
Identities = 67/253 (26%), Positives = 117/253 (46%), Gaps = 31/253 (12%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++++ K G L ++L+L D DP ++ D + TPL A + +I L++
Sbjct: 445 LYLSVKQGELQKVILMLLDNLDPNFQS-----DQQSKRTPLHAAAQKGSVEICHVLLQ-- 497
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A I+AVD+ + L A + +V + +++ G V
Sbjct: 498 --------AGANINAVDKQQRTPLMEA---------VVNNHLEVARYMVQRGGCV-YSKE 539
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
+ T H+ A GN ++++ ++ ST V +N Q+S GWTP++ A H++++
Sbjct: 540 EDGSTCLHHAAKIGNLEMVSLLL---STGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRM 594
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY 1007
LLT A V + D E LH A+ G + + LL + +++ +G T LH+AA Y
Sbjct: 595 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 654
Query: 1008 AHLV-KFLIRDHN 1019
V FL R N
Sbjct: 655 HDCVLLFLSRGAN 667
Score = 67.7 bits (158), Expect = 4e-10
Identities = 46/172 (26%), Positives = 84/172 (48%), Gaps = 4/172 (2%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 505 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 562
Query: 119 DYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
G V V+A + G TP+ AA +++ A+ + DNE+ +H A+ G A
Sbjct: 563 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 622
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
AI E+L + + + G T +HIA+ + DC ++ +G + NK
Sbjct: 623 AIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 673
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 583 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 641
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 642 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 700
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 701 GVGNRAIRTEKIICRDVARGYENVPIPC 728
Score = 64.1 bits (149), Expect = 5e-09
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 16/200 (8%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 478 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 524
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
R ++ G + E+G LH A G++ +V LLLS +++ D G T +
Sbjct: 525 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 582
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLN 1379
A+ H H +++ +LL +GA++ TD LH A+ G + ++L + +
Sbjct: 583 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 642
Query: 1380 CAPIWFAASENHND-VLEYL 1398
P+ AA E+++D VL +L
Sbjct: 643 DTPLHIAARESYHDCVLLFL 662
Score = 52.4 bits (120), Expect = 2e-05
Identities = 46/192 (23%), Positives = 81/192 (42%), Gaps = 3/192 (1%)
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGK-TGLHIASTHGHYQMVEVLLGQGAEINA 1341
L+L+ G + V L+L + + +D+ K T LH A+ G ++ VLL GA INA
Sbjct: 445 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 504
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
DK TPL A HL V + + + G S+ + AA + +++ LL
Sbjct: 505 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 564
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKER 1461
+ D + ++ + H +I + +L A V NI ++ ++
Sbjct: 565 GQVDVNAQDSGG--WTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 622
Query: 1462 AKDLIAAGKQCE 1473
A + +C+
Sbjct: 623 AIAEVLLNARCD 634
Score = 50.0 bits (114), Expect = 9e-05
Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 2/156 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L L+V+ G V +L ++ + T LH AA++ V++ +L+ GA ++A
Sbjct: 445 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 504
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED-RTPMHLAAENGHAAIIELLAD 185
+ +TPL A + +Y R + ED T +H AA+ G+ ++ LL
Sbjct: 505 VDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 563
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + + G T + A+ + H + ML +G
Sbjct: 564 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 599
Score = 49.6 bits (113), Expect = 1e-04
Identities = 41/159 (25%), Positives = 68/159 (42%), Gaps = 4/159 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + GN MV LLS + + A G T + AA + +++ R+L+ GA
Sbjct: 542 GSTCLHHAAKIGNLEMVSLLLSTGQVD-VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGA 600
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
V T+ LH A+ G + + R + + TP+H+AA E+ H ++
Sbjct: 601 DVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 660
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L+ + R K+G T + A+ L +K
Sbjct: 661 FLSRGANPEL--RNKEGDTAWDLTPERSDVWFALQLNRK 697
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 480 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 539
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
+ T LH AA+I + + +L+L N G TP+ AA+ ++ + +LL
Sbjct: 540 -EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 598
Query: 787 GGD 789
G D
Sbjct: 599 GAD 601
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 478 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 535
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 536 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 565
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 576 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 633
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 634 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 693
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 694 LNRKLRLGVGNR 705
Score = 36.7 bits (81), Expect = 0.89
Identities = 63/272 (23%), Positives = 114/272 (41%), Gaps = 39/272 (14%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLATLVLLLEDGGDPL 791
L+++ + + K LMLL + PN ++ TP+H AA+ G++ +LL+ G +
Sbjct: 445 LYLSVKQGELQKVILMLLDN-LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 503
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
K TPL A + ++ R++++ +G V + +EDG++ L
Sbjct: 504 AVDK-------QQRTPLMEAVVNNHLEVARYMVQ-----RGGCVYSK-----EEDGSTCL 546
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENG-ADVSLQTRHNHETAFHYCAIAGNNDVMTEMI 910
H+A K+ + ++V L+ G DV+ Q T + A + +V+ ++
Sbjct: 547 HHAAKI---------GNLEMVSLLLSTGQVDVNAQDSGGW-TPIIWAAEHKHIEVIRMLL 596
Query: 911 AHISTADVSRALNRQN-SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
ADV+ N +N + W A G + LL + + G + LH+A
Sbjct: 597 TR--GADVTLTDNEENICLHW-----ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 649
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A Y L+ A + + G TA L
Sbjct: 650 ARESYHDCVLLFLSRGANPELRNKEGDTAWDL 681
>AL844853-4|CAI41853.1| 1210|Homo sapiens HLA-B associated transcript
8 protein.
Length = 1210
Score = 105 bits (251), Expect = 2e-21
Identities = 82/277 (29%), Positives = 133/277 (48%), Gaps = 6/277 (2%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH-NAMI 1022
SA+ L G + AL+ ++ K R L+L+ G V ++ D+ +
Sbjct: 619 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 678
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++
Sbjct: 679 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YM 737
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
Q V + +DG+TC H AA G+++++ L+ + V +A++ TP+ AAE
Sbjct: 738 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQDS-GGWTPIIWAAEH 795
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
H +V+R+L+ GA T + +H A+ G + +V+ + + G TPL
Sbjct: 796 KHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPL 855
Query: 1203 HIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
HIAA + V LS P E T L P
Sbjct: 856 HIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 892
Score = 91.1 bits (216), Expect = 4e-17
Identities = 65/213 (30%), Positives = 108/213 (50%), Gaps = 6/213 (2%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 686 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 744
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
T LH AA G +E+ LLL G +++A D G PI AA++ + EV+++
Sbjct: 745 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 804
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L + ++ + T + N C H A+ GS + E L+ + + A N D TPL +AA
Sbjct: 805 LTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGD-TPLHIAAR 860
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ D V + + GA+ N+ G TA L E
Sbjct: 861 ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
Score = 81.4 bits (192), Expect = 3e-14
Identities = 76/249 (30%), Positives = 113/249 (45%), Gaps = 18/249 (7%)
Query: 1101 HIAAIQGSV-KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
+++ QG + KVI LM D ++ + TPL AA+ G ++ VL++AGA+
Sbjct: 655 YLSVKQGELQKVI--LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 712
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
++ T + A + H V M S ++ G T LH AA G E V LLS
Sbjct: 713 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 772
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G V A G TP+ AA + + V+R+LL + G NE
Sbjct: 773 --TGQVDVNAQDS----------GGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEEN 819
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
LH A F G +I +LL+ +L H+ + HG T LHIA+ ++ V + L +GA
Sbjct: 820 IC-LHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 877
Query: 1340 NATDKNGWT 1348
+K G T
Sbjct: 878 ELRNKEGDT 886
Score = 79.4 bits (187), Expect = 1e-13
Identities = 50/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+S TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 683 QSKRTPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQR 740
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLN 1360
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+ AA+ H+
Sbjct: 741 GG-CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIE 799
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
V+++L GA N + +A+ + E LL+ D ++
Sbjct: 800 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 847
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/207 (30%), Positives = 96/207 (46%), Gaps = 15/207 (7%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 687 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 745
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
S+ E G T LH AA GN +V LLL++ V +A + G+ P+ A
Sbjct: 746 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA-QDSGGWTPIIWA 792
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
H+ ++ +LL+R A++ TD LH AS G + EVLL +++A + +G
Sbjct: 793 AEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 851
Query: 1347 WTPLHCAAKAGHLNVVKLLCESGASPK 1373
TPLH AA+ + + V L GA+P+
Sbjct: 852 DTPLHIAARESYHDCVLLFLSRGANPE 878
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL A +G +++ + LL A ++ D + R+ L A + +L+V ++ + S
Sbjct: 687 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 746
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K +G T LH AA G +V L+ ++ TP+ AA IEV ++LL
Sbjct: 747 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 806
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
GA++ TD +H A+ + + ++ L +L A G+T HIAA +
Sbjct: 807 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHD 865
Query: 1111 VIEELMKFDRTGVISARNKLNDS 1133
+ L+ R RNK D+
Sbjct: 866 CV--LLFLSRGANPELRNKEGDT 886
Score = 69.3 bits (162), Expect = 1e-10
Identities = 67/253 (26%), Positives = 117/253 (46%), Gaps = 31/253 (12%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++++ K G L ++L+L D DP ++ D + TPL A + +I L++
Sbjct: 654 LYLSVKQGELQKVILMLLDNLDPNFQS-----DQQSKRTPLHAAAQKGSVEICHVLLQ-- 706
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A I+AVD+ + L A + +V + +++ G V
Sbjct: 707 --------AGANINAVDKQQRTPLMEA---------VVNNHLEVARYMVQRGGCV-YSKE 748
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
+ T H+ A GN ++++ ++ ST V +N Q+S GWTP++ A H++++
Sbjct: 749 EDGSTCLHHAAKIGNLEMVSLLL---STGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRM 803
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY 1007
LLT A V + D E LH A+ G + + LL + +++ +G T LH+AA Y
Sbjct: 804 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 863
Query: 1008 AHLV-KFLIRDHN 1019
V FL R N
Sbjct: 864 HDCVLLFLSRGAN 876
Score = 67.7 bits (158), Expect = 4e-10
Identities = 46/172 (26%), Positives = 84/172 (48%), Gaps = 4/172 (2%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 714 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 771
Query: 119 DYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
G V V+A + G TP+ AA +++ A+ + DNE+ +H A+ G A
Sbjct: 772 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 831
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
AI E+L + + + G T +HIA+ + DC ++ +G + NK
Sbjct: 832 AIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 882
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 792 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 850
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 851 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 909
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 910 GVGNRAIRTEKIICRDVARGYENVPIPC 937
Score = 64.1 bits (149), Expect = 5e-09
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 16/200 (8%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 687 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 733
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
R ++ G + E+G LH A G++ +V LLLS +++ D G T +
Sbjct: 734 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 791
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLN 1379
A+ H H +++ +LL +GA++ TD LH A+ G + ++L + +
Sbjct: 792 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 851
Query: 1380 CAPIWFAASENHND-VLEYL 1398
P+ AA E+++D VL +L
Sbjct: 852 DTPLHIAARESYHDCVLLFL 871
Score = 52.4 bits (120), Expect = 2e-05
Identities = 46/192 (23%), Positives = 81/192 (42%), Gaps = 3/192 (1%)
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGK-TGLHIASTHGHYQMVEVLLGQGAEINA 1341
L+L+ G + V L+L + + +D+ K T LH A+ G ++ VLL GA INA
Sbjct: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
DK TPL A HL V + + + G S+ + AA + +++ LL
Sbjct: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKER 1461
+ D + ++ + H +I + +L A V NI ++ ++
Sbjct: 774 GQVDVNAQDSGG--WTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 831
Query: 1462 AKDLIAAGKQCE 1473
A + +C+
Sbjct: 832 AIAEVLLNARCD 843
Score = 50.0 bits (114), Expect = 9e-05
Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 2/156 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L L+V+ G V +L ++ + T LH AA++ V++ +L+ GA ++A
Sbjct: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED-RTPMHLAAENGHAAIIELLAD 185
+ +TPL A + +Y R + ED T +H AA+ G+ ++ LL
Sbjct: 714 VDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 772
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + + G T + A+ + H + ML +G
Sbjct: 773 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 808
Score = 49.6 bits (113), Expect = 1e-04
Identities = 41/159 (25%), Positives = 68/159 (42%), Gaps = 4/159 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + GN MV LLS + + A G T + AA + +++ R+L+ GA
Sbjct: 751 GSTCLHHAAKIGNLEMVSLLLSTGQVD-VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGA 809
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
V T+ LH A+ G + + R + + TP+H+AA E+ H ++
Sbjct: 810 DVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 869
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L+ + R K+G T + A+ L +K
Sbjct: 870 FLSRGANPEL--RNKEGDTAWDLTPERSDVWFALQLNRK 906
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 689 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 748
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
+ T LH AA+I + + +L+L N G TP+ AA+ ++ + +LL
Sbjct: 749 -EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807
Query: 787 GGD 789
G D
Sbjct: 808 GAD 810
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 687 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 744
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 745 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 774
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 785 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 842
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 843 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 902
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 903 LNRKLRLGVGNR 914
Score = 36.7 bits (81), Expect = 0.89
Identities = 63/272 (23%), Positives = 114/272 (41%), Gaps = 39/272 (14%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLATLVLLLEDGGDPL 791
L+++ + + K LMLL + PN ++ TP+H AA+ G++ +LL+ G +
Sbjct: 654 LYLSVKQGELQKVILMLLDN-LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 712
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
K TPL A + ++ R++++ +G V + +EDG++ L
Sbjct: 713 AVDK-------QQRTPLMEAVVNNHLEVARYMVQ-----RGGCVYSK-----EEDGSTCL 755
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENG-ADVSLQTRHNHETAFHYCAIAGNNDVMTEMI 910
H+A K+ + ++V L+ G DV+ Q T + A + +V+ ++
Sbjct: 756 HHAAKI---------GNLEMVSLLLSTGQVDVNAQDSGGW-TPIIWAAEHKHIEVIRMLL 805
Query: 911 AHISTADVSRALNRQN-SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
ADV+ N +N + W A G + LL + + G + LH+A
Sbjct: 806 TR--GADVTLTDNEENICLHW-----ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 858
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A Y L+ A + + G TA L
Sbjct: 859 ARESYHDCVLLFLSRGANPELRNKEGDTAWDL 890
>AL844853-3|CAI41852.1| 1176|Homo sapiens HLA-B associated transcript
8 protein.
Length = 1176
Score = 105 bits (251), Expect = 2e-21
Identities = 82/277 (29%), Positives = 133/277 (48%), Gaps = 6/277 (2%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH-NAMI 1022
SA+ L G + AL+ ++ K R L+L+ G V ++ D+ +
Sbjct: 585 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 644
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++
Sbjct: 645 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YM 703
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
Q V + +DG+TC H AA G+++++ L+ + V +A++ TP+ AAE
Sbjct: 704 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQDS-GGWTPIIWAAEH 761
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
H +V+R+L+ GA T + +H A+ G + +V+ + + G TPL
Sbjct: 762 KHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPL 821
Query: 1203 HIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
HIAA + V LS P E T L P
Sbjct: 822 HIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 858
Score = 91.1 bits (216), Expect = 4e-17
Identities = 65/213 (30%), Positives = 108/213 (50%), Gaps = 6/213 (2%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 652 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 710
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
T LH AA G +E+ LLL G +++A D G PI AA++ + EV+++
Sbjct: 711 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 770
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L + ++ + T + N C H A+ GS + E L+ + + A N D TPL +AA
Sbjct: 771 LTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGD-TPLHIAAR 826
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ D V + + GA+ N+ G TA L E
Sbjct: 827 ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 859
Score = 81.4 bits (192), Expect = 3e-14
Identities = 76/249 (30%), Positives = 113/249 (45%), Gaps = 18/249 (7%)
Query: 1101 HIAAIQGSV-KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
+++ QG + KVI LM D ++ + TPL AA+ G ++ VL++AGA+
Sbjct: 621 YLSVKQGELQKVI--LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 678
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
++ T + A + H V M S ++ G T LH AA G E V LLS
Sbjct: 679 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 738
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G V A G TP+ AA + + V+R+LL + G NE
Sbjct: 739 --TGQVDVNAQDS----------GGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEEN 785
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
LH A F G +I +LL+ +L H+ + HG T LHIA+ ++ V + L +GA
Sbjct: 786 IC-LHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 843
Query: 1340 NATDKNGWT 1348
+K G T
Sbjct: 844 ELRNKEGDT 852
Score = 79.4 bits (187), Expect = 1e-13
Identities = 50/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+S TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 649 QSKRTPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQR 706
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLN 1360
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+ AA+ H+
Sbjct: 707 GG-CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIE 765
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
V+++L GA N + +A+ + E LL+ D ++
Sbjct: 766 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 813
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/207 (30%), Positives = 96/207 (46%), Gaps = 15/207 (7%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 653 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 711
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
S+ E G T LH AA GN +V LLL++ V +A + G+ P+ A
Sbjct: 712 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA-QDSGGWTPIIWA 758
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
H+ ++ +LL+R A++ TD LH AS G + EVLL +++A + +G
Sbjct: 759 AEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 817
Query: 1347 WTPLHCAAKAGHLNVVKLLCESGASPK 1373
TPLH AA+ + + V L GA+P+
Sbjct: 818 DTPLHIAARESYHDCVLLFLSRGANPE 844
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL A +G +++ + LL A ++ D + R+ L A + +L+V ++ + S
Sbjct: 653 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 712
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K +G T LH AA G +V L+ ++ TP+ AA IEV ++LL
Sbjct: 713 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 772
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
GA++ TD +H A+ + + ++ L +L A G+T HIAA +
Sbjct: 773 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHD 831
Query: 1111 VIEELMKFDRTGVISARNKLNDS 1133
+ L+ R RNK D+
Sbjct: 832 CV--LLFLSRGANPELRNKEGDT 852
Score = 69.3 bits (162), Expect = 1e-10
Identities = 67/253 (26%), Positives = 117/253 (46%), Gaps = 31/253 (12%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++++ K G L ++L+L D DP ++ D + TPL A + +I L++
Sbjct: 620 LYLSVKQGELQKVILMLLDNLDPNFQS-----DQQSKRTPLHAAAQKGSVEICHVLLQ-- 672
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A I+AVD+ + L A + +V + +++ G V
Sbjct: 673 --------AGANINAVDKQQRTPLMEA---------VVNNHLEVARYMVQRGGCV-YSKE 714
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
+ T H+ A GN ++++ ++ ST V +N Q+S GWTP++ A H++++
Sbjct: 715 EDGSTCLHHAAKIGNLEMVSLLL---STGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRM 769
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY 1007
LLT A V + D E LH A+ G + + LL + +++ +G T LH+AA Y
Sbjct: 770 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 829
Query: 1008 AHLV-KFLIRDHN 1019
V FL R N
Sbjct: 830 HDCVLLFLSRGAN 842
Score = 67.7 bits (158), Expect = 4e-10
Identities = 46/172 (26%), Positives = 84/172 (48%), Gaps = 4/172 (2%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 680 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 737
Query: 119 DYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
G V V+A + G TP+ AA +++ A+ + DNE+ +H A+ G A
Sbjct: 738 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 797
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
AI E+L + + + G T +HIA+ + DC ++ +G + NK
Sbjct: 798 AIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 848
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 758 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 816
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 817 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 875
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 876 GVGNRAIRTEKIICRDVARGYENVPIPC 903
Score = 64.1 bits (149), Expect = 5e-09
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 16/200 (8%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 653 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 699
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
R ++ G + E+G LH A G++ +V LLLS +++ D G T +
Sbjct: 700 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 757
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLN 1379
A+ H H +++ +LL +GA++ TD LH A+ G + ++L + +
Sbjct: 758 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 817
Query: 1380 CAPIWFAASENHND-VLEYL 1398
P+ AA E+++D VL +L
Sbjct: 818 DTPLHIAARESYHDCVLLFL 837
Score = 52.4 bits (120), Expect = 2e-05
Identities = 46/192 (23%), Positives = 81/192 (42%), Gaps = 3/192 (1%)
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGK-TGLHIASTHGHYQMVEVLLGQGAEINA 1341
L+L+ G + V L+L + + +D+ K T LH A+ G ++ VLL GA INA
Sbjct: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
DK TPL A HL V + + + G S+ + AA + +++ LL
Sbjct: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKER 1461
+ D + ++ + H +I + +L A V NI ++ ++
Sbjct: 740 GQVDVNAQDSGG--WTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 797
Query: 1462 AKDLIAAGKQCE 1473
A + +C+
Sbjct: 798 AIAEVLLNARCD 809
Score = 50.0 bits (114), Expect = 9e-05
Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 2/156 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L L+V+ G V +L ++ + T LH AA++ V++ +L+ GA ++A
Sbjct: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED-RTPMHLAAENGHAAIIELLAD 185
+ +TPL A + +Y R + ED T +H AA+ G+ ++ LL
Sbjct: 680 VDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 738
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + + G T + A+ + H + ML +G
Sbjct: 739 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 774
Score = 49.6 bits (113), Expect = 1e-04
Identities = 41/159 (25%), Positives = 68/159 (42%), Gaps = 4/159 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + GN MV LLS + + A G T + AA + +++ R+L+ GA
Sbjct: 717 GSTCLHHAAKIGNLEMVSLLLSTGQVD-VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGA 775
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
V T+ LH A+ G + + R + + TP+H+AA E+ H ++
Sbjct: 776 DVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 835
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L+ + R K+G T + A+ L +K
Sbjct: 836 FLSRGANPEL--RNKEGDTAWDLTPERSDVWFALQLNRK 872
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 655 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 714
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
+ T LH AA+I + + +L+L N G TP+ AA+ ++ + +LL
Sbjct: 715 -EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 773
Query: 787 GGD 789
G D
Sbjct: 774 GAD 776
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 653 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 710
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 711 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 740
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 751 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 808
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 809 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 868
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 869 LNRKLRLGVGNR 880
Score = 36.7 bits (81), Expect = 0.89
Identities = 63/272 (23%), Positives = 114/272 (41%), Gaps = 39/272 (14%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLATLVLLLEDGGDPL 791
L+++ + + K LMLL + PN ++ TP+H AA+ G++ +LL+ G +
Sbjct: 620 LYLSVKQGELQKVILMLLDN-LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 678
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
K TPL A + ++ R++++ +G V + +EDG++ L
Sbjct: 679 AVDK-------QQRTPLMEAVVNNHLEVARYMVQ-----RGGCVYSK-----EEDGSTCL 721
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENG-ADVSLQTRHNHETAFHYCAIAGNNDVMTEMI 910
H+A K+ + ++V L+ G DV+ Q T + A + +V+ ++
Sbjct: 722 HHAAKI---------GNLEMVSLLLSTGQVDVNAQDSGGW-TPIIWAAEHKHIEVIRMLL 771
Query: 911 AHISTADVSRALNRQN-SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
ADV+ N +N + W A G + LL + + G + LH+A
Sbjct: 772 TR--GADVTLTDNEENICLHW-----ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 824
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A Y L+ A + + G TA L
Sbjct: 825 ARESYHDCVLLFLSRGANPELRNKEGDTAWDL 856
>AL671762-16|CAI18224.2| 1210|Homo sapiens euchromatic histone-lysine
N-methyltransferase 2 protein.
Length = 1210
Score = 105 bits (251), Expect = 2e-21
Identities = 82/277 (29%), Positives = 133/277 (48%), Gaps = 6/277 (2%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH-NAMI 1022
SA+ L G + AL+ ++ K R L+L+ G V ++ D+ +
Sbjct: 619 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 678
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++
Sbjct: 679 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YM 737
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
Q V + +DG+TC H AA G+++++ L+ + V +A++ TP+ AAE
Sbjct: 738 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQDS-GGWTPIIWAAEH 795
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
H +V+R+L+ GA T + +H A+ G + +V+ + + G TPL
Sbjct: 796 KHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPL 855
Query: 1203 HIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
HIAA + V LS P E T L P
Sbjct: 856 HIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 892
Score = 91.1 bits (216), Expect = 4e-17
Identities = 65/213 (30%), Positives = 108/213 (50%), Gaps = 6/213 (2%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 686 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 744
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
T LH AA G +E+ LLL G +++A D G PI AA++ + EV+++
Sbjct: 745 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 804
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L + ++ + T + N C H A+ GS + E L+ + + A N D TPL +AA
Sbjct: 805 LTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGD-TPLHIAAR 860
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ D V + + GA+ N+ G TA L E
Sbjct: 861 ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
Score = 81.4 bits (192), Expect = 3e-14
Identities = 76/249 (30%), Positives = 113/249 (45%), Gaps = 18/249 (7%)
Query: 1101 HIAAIQGSV-KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
+++ QG + KVI LM D ++ + TPL AA+ G ++ VL++AGA+
Sbjct: 655 YLSVKQGELQKVI--LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 712
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
++ T + A + H V M S ++ G T LH AA G E V LLS
Sbjct: 713 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 772
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G V A G TP+ AA + + V+R+LL + G NE
Sbjct: 773 --TGQVDVNAQDS----------GGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEEN 819
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
LH A F G +I +LL+ +L H+ + HG T LHIA+ ++ V + L +GA
Sbjct: 820 IC-LHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 877
Query: 1340 NATDKNGWT 1348
+K G T
Sbjct: 878 ELRNKEGDT 886
Score = 79.4 bits (187), Expect = 1e-13
Identities = 50/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+S TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 683 QSKRTPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQR 740
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLN 1360
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+ AA+ H+
Sbjct: 741 GG-CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIE 799
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
V+++L GA N + +A+ + E LL+ D ++
Sbjct: 800 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 847
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/207 (30%), Positives = 96/207 (46%), Gaps = 15/207 (7%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 687 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 745
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
S+ E G T LH AA GN +V LLL++ V +A + G+ P+ A
Sbjct: 746 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA-QDSGGWTPIIWA 792
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
H+ ++ +LL+R A++ TD LH AS G + EVLL +++A + +G
Sbjct: 793 AEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 851
Query: 1347 WTPLHCAAKAGHLNVVKLLCESGASPK 1373
TPLH AA+ + + V L GA+P+
Sbjct: 852 DTPLHIAARESYHDCVLLFLSRGANPE 878
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL A +G +++ + LL A ++ D + R+ L A + +L+V ++ + S
Sbjct: 687 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 746
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K +G T LH AA G +V L+ ++ TP+ AA IEV ++LL
Sbjct: 747 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 806
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
GA++ TD +H A+ + + ++ L +L A G+T HIAA +
Sbjct: 807 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHD 865
Query: 1111 VIEELMKFDRTGVISARNKLNDS 1133
+ L+ R RNK D+
Sbjct: 866 CV--LLFLSRGANPELRNKEGDT 886
Score = 69.3 bits (162), Expect = 1e-10
Identities = 67/253 (26%), Positives = 117/253 (46%), Gaps = 31/253 (12%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++++ K G L ++L+L D DP ++ D + TPL A + +I L++
Sbjct: 654 LYLSVKQGELQKVILMLLDNLDPNFQS-----DQQSKRTPLHAAAQKGSVEICHVLLQ-- 706
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A I+AVD+ + L A + +V + +++ G V
Sbjct: 707 --------AGANINAVDKQQRTPLMEA---------VVNNHLEVARYMVQRGGCV-YSKE 748
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
+ T H+ A GN ++++ ++ ST V +N Q+S GWTP++ A H++++
Sbjct: 749 EDGSTCLHHAAKIGNLEMVSLLL---STGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRM 803
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY 1007
LLT A V + D E LH A+ G + + LL + +++ +G T LH+AA Y
Sbjct: 804 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 863
Query: 1008 AHLV-KFLIRDHN 1019
V FL R N
Sbjct: 864 HDCVLLFLSRGAN 876
Score = 67.7 bits (158), Expect = 4e-10
Identities = 46/172 (26%), Positives = 84/172 (48%), Gaps = 4/172 (2%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 714 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 771
Query: 119 DYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
G V V+A + G TP+ AA +++ A+ + DNE+ +H A+ G A
Sbjct: 772 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 831
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
AI E+L + + + G T +HIA+ + DC ++ +G + NK
Sbjct: 832 AIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 882
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 792 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 850
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 851 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 909
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 910 GVGNRAIRTEKIICRDVARGYENVPIPC 937
Score = 64.1 bits (149), Expect = 5e-09
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 16/200 (8%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 687 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 733
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
R ++ G + E+G LH A G++ +V LLLS +++ D G T +
Sbjct: 734 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 791
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLN 1379
A+ H H +++ +LL +GA++ TD LH A+ G + ++L + +
Sbjct: 792 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 851
Query: 1380 CAPIWFAASENHND-VLEYL 1398
P+ AA E+++D VL +L
Sbjct: 852 DTPLHIAARESYHDCVLLFL 871
Score = 52.4 bits (120), Expect = 2e-05
Identities = 46/192 (23%), Positives = 81/192 (42%), Gaps = 3/192 (1%)
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGK-TGLHIASTHGHYQMVEVLLGQGAEINA 1341
L+L+ G + V L+L + + +D+ K T LH A+ G ++ VLL GA INA
Sbjct: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
DK TPL A HL V + + + G S+ + AA + +++ LL
Sbjct: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKER 1461
+ D + ++ + H +I + +L A V NI ++ ++
Sbjct: 774 GQVDVNAQDSGG--WTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 831
Query: 1462 AKDLIAAGKQCE 1473
A + +C+
Sbjct: 832 AIAEVLLNARCD 843
Score = 50.0 bits (114), Expect = 9e-05
Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 2/156 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L L+V+ G V +L ++ + T LH AA++ V++ +L+ GA ++A
Sbjct: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED-RTPMHLAAENGHAAIIELLAD 185
+ +TPL A + +Y R + ED T +H AA+ G+ ++ LL
Sbjct: 714 VDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 772
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + + G T + A+ + H + ML +G
Sbjct: 773 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 808
Score = 49.6 bits (113), Expect = 1e-04
Identities = 41/159 (25%), Positives = 68/159 (42%), Gaps = 4/159 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + GN MV LLS + + A G T + AA + +++ R+L+ GA
Sbjct: 751 GSTCLHHAAKIGNLEMVSLLLSTGQVD-VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGA 809
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
V T+ LH A+ G + + R + + TP+H+AA E+ H ++
Sbjct: 810 DVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 869
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L+ + R K+G T + A+ L +K
Sbjct: 870 FLSRGANPEL--RNKEGDTAWDLTPERSDVWFALQLNRK 906
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 689 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 748
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
+ T LH AA+I + + +L+L N G TP+ AA+ ++ + +LL
Sbjct: 749 -EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807
Query: 787 GGD 789
G D
Sbjct: 808 GAD 810
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 687 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 744
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 745 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 774
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 785 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 842
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 843 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 902
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 903 LNRKLRLGVGNR 914
Score = 36.7 bits (81), Expect = 0.89
Identities = 63/272 (23%), Positives = 114/272 (41%), Gaps = 39/272 (14%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLATLVLLLEDGGDPL 791
L+++ + + K LMLL + PN ++ TP+H AA+ G++ +LL+ G +
Sbjct: 654 LYLSVKQGELQKVILMLLDN-LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 712
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
K TPL A + ++ R++++ +G V + +EDG++ L
Sbjct: 713 AVDK-------QQRTPLMEAVVNNHLEVARYMVQ-----RGGCVYSK-----EEDGSTCL 755
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENG-ADVSLQTRHNHETAFHYCAIAGNNDVMTEMI 910
H+A K+ + ++V L+ G DV+ Q T + A + +V+ ++
Sbjct: 756 HHAAKI---------GNLEMVSLLLSTGQVDVNAQDSGGW-TPIIWAAEHKHIEVIRMLL 805
Query: 911 AHISTADVSRALNRQN-SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
ADV+ N +N + W A G + LL + + G + LH+A
Sbjct: 806 TR--GADVTLTDNEENICLHW-----ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 858
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A Y L+ A + + G TA L
Sbjct: 859 ARESYHDCVLLFLSRGANPELRNKEGDTAWDL 890
>AL671762-15|CAI18226.2| 1176|Homo sapiens euchromatic histone-lysine
N-methyltransferase 2 protein.
Length = 1176
Score = 105 bits (251), Expect = 2e-21
Identities = 82/277 (29%), Positives = 133/277 (48%), Gaps = 6/277 (2%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH-NAMI 1022
SA+ L G + AL+ ++ K R L+L+ G V ++ D+ +
Sbjct: 585 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 644
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++
Sbjct: 645 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YM 703
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
Q V + +DG+TC H AA G+++++ L+ + V +A++ TP+ AAE
Sbjct: 704 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQDS-GGWTPIIWAAEH 761
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
H +V+R+L+ GA T + +H A+ G + +V+ + + G TPL
Sbjct: 762 KHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPL 821
Query: 1203 HIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
HIAA + V LS P E T L P
Sbjct: 822 HIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 858
Score = 91.1 bits (216), Expect = 4e-17
Identities = 65/213 (30%), Positives = 108/213 (50%), Gaps = 6/213 (2%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 652 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 710
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
T LH AA G +E+ LLL G +++A D G PI AA++ + EV+++
Sbjct: 711 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 770
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L + ++ + T + N C H A+ GS + E L+ + + A N D TPL +AA
Sbjct: 771 LTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGD-TPLHIAAR 826
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ D V + + GA+ N+ G TA L E
Sbjct: 827 ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 859
Score = 81.4 bits (192), Expect = 3e-14
Identities = 76/249 (30%), Positives = 113/249 (45%), Gaps = 18/249 (7%)
Query: 1101 HIAAIQGSV-KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
+++ QG + KVI LM D ++ + TPL AA+ G ++ VL++AGA+
Sbjct: 621 YLSVKQGELQKVI--LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 678
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
++ T + A + H V M S ++ G T LH AA G E V LLS
Sbjct: 679 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 738
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G V A G TP+ AA + + V+R+LL + G NE
Sbjct: 739 --TGQVDVNAQDS----------GGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEEN 785
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
LH A F G +I +LL+ +L H+ + HG T LHIA+ ++ V + L +GA
Sbjct: 786 IC-LHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 843
Query: 1340 NATDKNGWT 1348
+K G T
Sbjct: 844 ELRNKEGDT 852
Score = 79.4 bits (187), Expect = 1e-13
Identities = 50/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+S TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 649 QSKRTPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQR 706
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLN 1360
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+ AA+ H+
Sbjct: 707 GG-CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIE 765
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
V+++L GA N + +A+ + E LL+ D ++
Sbjct: 766 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 813
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/207 (30%), Positives = 96/207 (46%), Gaps = 15/207 (7%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 653 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 711
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
S+ E G T LH AA GN +V LLL++ V +A + G+ P+ A
Sbjct: 712 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA-QDSGGWTPIIWA 758
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
H+ ++ +LL+R A++ TD LH AS G + EVLL +++A + +G
Sbjct: 759 AEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 817
Query: 1347 WTPLHCAAKAGHLNVVKLLCESGASPK 1373
TPLH AA+ + + V L GA+P+
Sbjct: 818 DTPLHIAARESYHDCVLLFLSRGANPE 844
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL A +G +++ + LL A ++ D + R+ L A + +L+V ++ + S
Sbjct: 653 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 712
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K +G T LH AA G +V L+ ++ TP+ AA IEV ++LL
Sbjct: 713 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 772
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
GA++ TD +H A+ + + ++ L +L A G+T HIAA +
Sbjct: 773 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHD 831
Query: 1111 VIEELMKFDRTGVISARNKLNDS 1133
+ L+ R RNK D+
Sbjct: 832 CV--LLFLSRGANPELRNKEGDT 852
Score = 69.3 bits (162), Expect = 1e-10
Identities = 67/253 (26%), Positives = 117/253 (46%), Gaps = 31/253 (12%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++++ K G L ++L+L D DP ++ D + TPL A + +I L++
Sbjct: 620 LYLSVKQGELQKVILMLLDNLDPNFQS-----DQQSKRTPLHAAAQKGSVEICHVLLQ-- 672
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A I+AVD+ + L A + +V + +++ G V
Sbjct: 673 --------AGANINAVDKQQRTPLMEA---------VVNNHLEVARYMVQRGGCV-YSKE 714
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
+ T H+ A GN ++++ ++ ST V +N Q+S GWTP++ A H++++
Sbjct: 715 EDGSTCLHHAAKIGNLEMVSLLL---STGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRM 769
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY 1007
LLT A V + D E LH A+ G + + LL + +++ +G T LH+AA Y
Sbjct: 770 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 829
Query: 1008 AHLV-KFLIRDHN 1019
V FL R N
Sbjct: 830 HDCVLLFLSRGAN 842
Score = 67.7 bits (158), Expect = 4e-10
Identities = 46/172 (26%), Positives = 84/172 (48%), Gaps = 4/172 (2%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 680 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 737
Query: 119 DYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
G V V+A + G TP+ AA +++ A+ + DNE+ +H A+ G A
Sbjct: 738 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 797
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
AI E+L + + + G T +HIA+ + DC ++ +G + NK
Sbjct: 798 AIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 848
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 758 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 816
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 817 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 875
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 876 GVGNRAIRTEKIICRDVARGYENVPIPC 903
Score = 64.1 bits (149), Expect = 5e-09
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 16/200 (8%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 653 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 699
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
R ++ G + E+G LH A G++ +V LLLS +++ D G T +
Sbjct: 700 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 757
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLN 1379
A+ H H +++ +LL +GA++ TD LH A+ G + ++L + +
Sbjct: 758 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 817
Query: 1380 CAPIWFAASENHND-VLEYL 1398
P+ AA E+++D VL +L
Sbjct: 818 DTPLHIAARESYHDCVLLFL 837
Score = 52.4 bits (120), Expect = 2e-05
Identities = 46/192 (23%), Positives = 81/192 (42%), Gaps = 3/192 (1%)
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGK-TGLHIASTHGHYQMVEVLLGQGAEINA 1341
L+L+ G + V L+L + + +D+ K T LH A+ G ++ VLL GA INA
Sbjct: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
DK TPL A HL V + + + G S+ + AA + +++ LL
Sbjct: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKER 1461
+ D + ++ + H +I + +L A V NI ++ ++
Sbjct: 740 GQVDVNAQDSGG--WTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 797
Query: 1462 AKDLIAAGKQCE 1473
A + +C+
Sbjct: 798 AIAEVLLNARCD 809
Score = 50.0 bits (114), Expect = 9e-05
Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 2/156 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L L+V+ G V +L ++ + T LH AA++ V++ +L+ GA ++A
Sbjct: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED-RTPMHLAAENGHAAIIELLAD 185
+ +TPL A + +Y R + ED T +H AA+ G+ ++ LL
Sbjct: 680 VDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 738
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + + G T + A+ + H + ML +G
Sbjct: 739 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 774
Score = 49.6 bits (113), Expect = 1e-04
Identities = 41/159 (25%), Positives = 68/159 (42%), Gaps = 4/159 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + GN MV LLS + + A G T + AA + +++ R+L+ GA
Sbjct: 717 GSTCLHHAAKIGNLEMVSLLLSTGQVD-VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGA 775
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
V T+ LH A+ G + + R + + TP+H+AA E+ H ++
Sbjct: 776 DVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 835
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L+ + R K+G T + A+ L +K
Sbjct: 836 FLSRGANPEL--RNKEGDTAWDLTPERSDVWFALQLNRK 872
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 655 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 714
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
+ T LH AA+I + + +L+L N G TP+ AA+ ++ + +LL
Sbjct: 715 -EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 773
Query: 787 GGD 789
G D
Sbjct: 774 GAD 776
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 653 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 710
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 711 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 740
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 751 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 808
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 809 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 868
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 869 LNRKLRLGVGNR 880
Score = 36.7 bits (81), Expect = 0.89
Identities = 63/272 (23%), Positives = 114/272 (41%), Gaps = 39/272 (14%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLATLVLLLEDGGDPL 791
L+++ + + K LMLL + PN ++ TP+H AA+ G++ +LL+ G +
Sbjct: 620 LYLSVKQGELQKVILMLLDN-LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 678
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
K TPL A + ++ R++++ +G V + +EDG++ L
Sbjct: 679 AVDK-------QQRTPLMEAVVNNHLEVARYMVQ-----RGGCVYSK-----EEDGSTCL 721
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENG-ADVSLQTRHNHETAFHYCAIAGNNDVMTEMI 910
H+A K+ + ++V L+ G DV+ Q T + A + +V+ ++
Sbjct: 722 HHAAKI---------GNLEMVSLLLSTGQVDVNAQDSGGW-TPIIWAAEHKHIEVIRMLL 771
Query: 911 AHISTADVSRALNRQN-SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
ADV+ N +N + W A G + LL + + G + LH+A
Sbjct: 772 TR--GADVTLTDNEENICLHW-----ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 824
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A Y L+ A + + G TA L
Sbjct: 825 ARESYHDCVLLFLSRGANPELRNKEGDTAWDL 856
>AL671762-14|CAM25534.1| 1267|Homo sapiens euchromatic histone-lysine
N-methyltransferase 2 protein.
Length = 1267
Score = 105 bits (251), Expect = 2e-21
Identities = 82/277 (29%), Positives = 133/277 (48%), Gaps = 6/277 (2%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH-NAMI 1022
SA+ L G + AL+ ++ K R L+L+ G V ++ D+ +
Sbjct: 676 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 735
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++
Sbjct: 736 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YM 794
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
Q V + +DG+TC H AA G+++++ L+ + V +A++ TP+ AAE
Sbjct: 795 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQDS-GGWTPIIWAAEH 852
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
H +V+R+L+ GA T + +H A+ G + +V+ + + G TPL
Sbjct: 853 KHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPL 912
Query: 1203 HIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
HIAA + V LS P E T L P
Sbjct: 913 HIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 949
Score = 91.1 bits (216), Expect = 4e-17
Identities = 65/213 (30%), Positives = 108/213 (50%), Gaps = 6/213 (2%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 743 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 801
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
T LH AA G +E+ LLL G +++A D G PI AA++ + EV+++
Sbjct: 802 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 861
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L + ++ + T + N C H A+ GS + E L+ + + A N D TPL +AA
Sbjct: 862 LTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGD-TPLHIAAR 917
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ D V + + GA+ N+ G TA L E
Sbjct: 918 ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 950
Score = 81.4 bits (192), Expect = 3e-14
Identities = 76/249 (30%), Positives = 113/249 (45%), Gaps = 18/249 (7%)
Query: 1101 HIAAIQGSV-KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
+++ QG + KVI LM D ++ + TPL AA+ G ++ VL++AGA+
Sbjct: 712 YLSVKQGELQKVI--LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 769
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
++ T + A + H V M S ++ G T LH AA G E V LLS
Sbjct: 770 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 829
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G V A G TP+ AA + + V+R+LL + G NE
Sbjct: 830 --TGQVDVNAQDS----------GGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEEN 876
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
LH A F G +I +LL+ +L H+ + HG T LHIA+ ++ V + L +GA
Sbjct: 877 IC-LHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 934
Query: 1340 NATDKNGWT 1348
+K G T
Sbjct: 935 ELRNKEGDT 943
Score = 79.4 bits (187), Expect = 1e-13
Identities = 50/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+S TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 740 QSKRTPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQR 797
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLN 1360
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+ AA+ H+
Sbjct: 798 GG-CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIE 856
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
V+++L GA N + +A+ + E LL+ D ++
Sbjct: 857 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 904
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/207 (30%), Positives = 96/207 (46%), Gaps = 15/207 (7%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 744 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 802
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
S+ E G T LH AA GN +V LLL++ V +A + G+ P+ A
Sbjct: 803 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA-QDSGGWTPIIWA 849
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
H+ ++ +LL+R A++ TD LH AS G + EVLL +++A + +G
Sbjct: 850 AEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 908
Query: 1347 WTPLHCAAKAGHLNVVKLLCESGASPK 1373
TPLH AA+ + + V L GA+P+
Sbjct: 909 DTPLHIAARESYHDCVLLFLSRGANPE 935
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL A +G +++ + LL A ++ D + R+ L A + +L+V ++ + S
Sbjct: 744 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 803
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K +G T LH AA G +V L+ ++ TP+ AA IEV ++LL
Sbjct: 804 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 863
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
GA++ TD +H A+ + + ++ L +L A G+T HIAA +
Sbjct: 864 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHD 922
Query: 1111 VIEELMKFDRTGVISARNKLNDS 1133
+ L+ R RNK D+
Sbjct: 923 CV--LLFLSRGANPELRNKEGDT 943
Score = 69.3 bits (162), Expect = 1e-10
Identities = 67/253 (26%), Positives = 117/253 (46%), Gaps = 31/253 (12%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++++ K G L ++L+L D DP ++ D + TPL A + +I L++
Sbjct: 711 LYLSVKQGELQKVILMLLDNLDPNFQS-----DQQSKRTPLHAAAQKGSVEICHVLLQ-- 763
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A I+AVD+ + L A + +V + +++ G V
Sbjct: 764 --------AGANINAVDKQQRTPLMEA---------VVNNHLEVARYMVQRGGCV-YSKE 805
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
+ T H+ A GN ++++ ++ ST V +N Q+S GWTP++ A H++++
Sbjct: 806 EDGSTCLHHAAKIGNLEMVSLLL---STGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRM 860
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY 1007
LLT A V + D E LH A+ G + + LL + +++ +G T LH+AA Y
Sbjct: 861 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 920
Query: 1008 AHLV-KFLIRDHN 1019
V FL R N
Sbjct: 921 HDCVLLFLSRGAN 933
Score = 67.7 bits (158), Expect = 4e-10
Identities = 46/172 (26%), Positives = 84/172 (48%), Gaps = 4/172 (2%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 771 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 828
Query: 119 DYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
G V V+A + G TP+ AA +++ A+ + DNE+ +H A+ G A
Sbjct: 829 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 888
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
AI E+L + + + G T +HIA+ + DC ++ +G + NK
Sbjct: 889 AIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 939
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 849 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 907
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 908 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 966
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 967 GVGNRAIRTEKIICRDVARGYENVPIPC 994
Score = 64.1 bits (149), Expect = 5e-09
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 16/200 (8%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 744 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 790
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
R ++ G + E+G LH A G++ +V LLLS +++ D G T +
Sbjct: 791 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 848
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLN 1379
A+ H H +++ +LL +GA++ TD LH A+ G + ++L + +
Sbjct: 849 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 908
Query: 1380 CAPIWFAASENHND-VLEYL 1398
P+ AA E+++D VL +L
Sbjct: 909 DTPLHIAARESYHDCVLLFL 928
Score = 52.4 bits (120), Expect = 2e-05
Identities = 46/192 (23%), Positives = 81/192 (42%), Gaps = 3/192 (1%)
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGK-TGLHIASTHGHYQMVEVLLGQGAEINA 1341
L+L+ G + V L+L + + +D+ K T LH A+ G ++ VLL GA INA
Sbjct: 711 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 770
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
DK TPL A HL V + + + G S+ + AA + +++ LL
Sbjct: 771 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 830
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKER 1461
+ D + ++ + H +I + +L A V NI ++ ++
Sbjct: 831 GQVDVNAQDSGG--WTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 888
Query: 1462 AKDLIAAGKQCE 1473
A + +C+
Sbjct: 889 AIAEVLLNARCD 900
Score = 50.0 bits (114), Expect = 9e-05
Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 2/156 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L L+V+ G V +L ++ + T LH AA++ V++ +L+ GA ++A
Sbjct: 711 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 770
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED-RTPMHLAAENGHAAIIELLAD 185
+ +TPL A + +Y R + ED T +H AA+ G+ ++ LL
Sbjct: 771 VDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 829
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + + G T + A+ + H + ML +G
Sbjct: 830 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 865
Score = 49.6 bits (113), Expect = 1e-04
Identities = 41/159 (25%), Positives = 68/159 (42%), Gaps = 4/159 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + GN MV LLS + + A G T + AA + +++ R+L+ GA
Sbjct: 808 GSTCLHHAAKIGNLEMVSLLLSTGQVD-VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGA 866
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
V T+ LH A+ G + + R + + TP+H+AA E+ H ++
Sbjct: 867 DVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 926
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L+ + R K+G T + A+ L +K
Sbjct: 927 FLSRGANPEL--RNKEGDTAWDLTPERSDVWFALQLNRK 963
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 746 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 805
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
+ T LH AA+I + + +L+L N G TP+ AA+ ++ + +LL
Sbjct: 806 -EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 864
Query: 787 GGD 789
G D
Sbjct: 865 GAD 867
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 744 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 801
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 802 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 831
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 842 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 899
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 900 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 959
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 960 LNRKLRLGVGNR 971
Score = 36.7 bits (81), Expect = 0.89
Identities = 63/272 (23%), Positives = 114/272 (41%), Gaps = 39/272 (14%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLATLVLLLEDGGDPL 791
L+++ + + K LMLL + PN ++ TP+H AA+ G++ +LL+ G +
Sbjct: 711 LYLSVKQGELQKVILMLLDN-LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 769
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
K TPL A + ++ R++++ +G V + +EDG++ L
Sbjct: 770 AVDK-------QQRTPLMEAVVNNHLEVARYMVQ-----RGGCVYSK-----EEDGSTCL 812
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENG-ADVSLQTRHNHETAFHYCAIAGNNDVMTEMI 910
H+A K+ + ++V L+ G DV+ Q T + A + +V+ ++
Sbjct: 813 HHAAKI---------GNLEMVSLLLSTGQVDVNAQDSGGW-TPIIWAAEHKHIEVIRMLL 862
Query: 911 AHISTADVSRALNRQN-SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
ADV+ N +N + W A G + LL + + G + LH+A
Sbjct: 863 TR--GADVTLTDNEENICLHW-----ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 915
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A Y L+ A + + G TA L
Sbjct: 916 ARESYHDCVLLFLSRGANPELRNKEGDTAWDL 947
>AL671762-13|CAM25533.1| 1233|Homo sapiens euchromatic histone-lysine
N-methyltransferase 2 protein.
Length = 1233
Score = 105 bits (251), Expect = 2e-21
Identities = 82/277 (29%), Positives = 133/277 (48%), Gaps = 6/277 (2%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH-NAMI 1022
SA+ L G + AL+ ++ K R L+L+ G V ++ D+ +
Sbjct: 642 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 701
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++
Sbjct: 702 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YM 760
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
Q V + +DG+TC H AA G+++++ L+ + V +A++ TP+ AAE
Sbjct: 761 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQDS-GGWTPIIWAAEH 818
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
H +V+R+L+ GA T + +H A+ G + +V+ + + G TPL
Sbjct: 819 KHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPL 878
Query: 1203 HIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
HIAA + V LS P E T L P
Sbjct: 879 HIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 915
Score = 91.1 bits (216), Expect = 4e-17
Identities = 65/213 (30%), Positives = 108/213 (50%), Gaps = 6/213 (2%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 709 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 767
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
T LH AA G +E+ LLL G +++A D G PI AA++ + EV+++
Sbjct: 768 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 827
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L + ++ + T + N C H A+ GS + E L+ + + A N D TPL +AA
Sbjct: 828 LTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGD-TPLHIAAR 883
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ D V + + GA+ N+ G TA L E
Sbjct: 884 ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 916
Score = 81.4 bits (192), Expect = 3e-14
Identities = 76/249 (30%), Positives = 113/249 (45%), Gaps = 18/249 (7%)
Query: 1101 HIAAIQGSV-KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
+++ QG + KVI LM D ++ + TPL AA+ G ++ VL++AGA+
Sbjct: 678 YLSVKQGELQKVI--LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 735
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
++ T + A + H V M S ++ G T LH AA G E V LLS
Sbjct: 736 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 795
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G V A G TP+ AA + + V+R+LL + G NE
Sbjct: 796 --TGQVDVNAQDS----------GGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEEN 842
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
LH A F G +I +LL+ +L H+ + HG T LHIA+ ++ V + L +GA
Sbjct: 843 IC-LHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 900
Query: 1340 NATDKNGWT 1348
+K G T
Sbjct: 901 ELRNKEGDT 909
Score = 79.4 bits (187), Expect = 1e-13
Identities = 50/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+S TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 706 QSKRTPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQR 763
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLN 1360
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+ AA+ H+
Sbjct: 764 GG-CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIE 822
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
V+++L GA N + +A+ + E LL+ D ++
Sbjct: 823 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 870
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/207 (30%), Positives = 96/207 (46%), Gaps = 15/207 (7%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 710 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 768
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
S+ E G T LH AA GN +V LLL++ V +A + G+ P+ A
Sbjct: 769 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA-QDSGGWTPIIWA 815
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
H+ ++ +LL+R A++ TD LH AS G + EVLL +++A + +G
Sbjct: 816 AEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 874
Query: 1347 WTPLHCAAKAGHLNVVKLLCESGASPK 1373
TPLH AA+ + + V L GA+P+
Sbjct: 875 DTPLHIAARESYHDCVLLFLSRGANPE 901
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL A +G +++ + LL A ++ D + R+ L A + +L+V ++ + S
Sbjct: 710 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 769
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K +G T LH AA G +V L+ ++ TP+ AA IEV ++LL
Sbjct: 770 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 829
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
GA++ TD +H A+ + + ++ L +L A G+T HIAA +
Sbjct: 830 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHD 888
Query: 1111 VIEELMKFDRTGVISARNKLNDS 1133
+ L+ R RNK D+
Sbjct: 889 CV--LLFLSRGANPELRNKEGDT 909
Score = 69.3 bits (162), Expect = 1e-10
Identities = 67/253 (26%), Positives = 117/253 (46%), Gaps = 31/253 (12%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++++ K G L ++L+L D DP ++ D + TPL A + +I L++
Sbjct: 677 LYLSVKQGELQKVILMLLDNLDPNFQS-----DQQSKRTPLHAAAQKGSVEICHVLLQ-- 729
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A I+AVD+ + L A + +V + +++ G V
Sbjct: 730 --------AGANINAVDKQQRTPLMEA---------VVNNHLEVARYMVQRGGCV-YSKE 771
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
+ T H+ A GN ++++ ++ ST V +N Q+S GWTP++ A H++++
Sbjct: 772 EDGSTCLHHAAKIGNLEMVSLLL---STGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRM 826
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY 1007
LLT A V + D E LH A+ G + + LL + +++ +G T LH+AA Y
Sbjct: 827 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 886
Query: 1008 AHLV-KFLIRDHN 1019
V FL R N
Sbjct: 887 HDCVLLFLSRGAN 899
Score = 67.7 bits (158), Expect = 4e-10
Identities = 46/172 (26%), Positives = 84/172 (48%), Gaps = 4/172 (2%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 737 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 794
Query: 119 DYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
G V V+A + G TP+ AA +++ A+ + DNE+ +H A+ G A
Sbjct: 795 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 854
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
AI E+L + + + G T +HIA+ + DC ++ +G + NK
Sbjct: 855 AIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 905
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 815 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 873
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 874 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 932
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 933 GVGNRAIRTEKIICRDVARGYENVPIPC 960
Score = 64.1 bits (149), Expect = 5e-09
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 16/200 (8%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 710 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 756
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
R ++ G + E+G LH A G++ +V LLLS +++ D G T +
Sbjct: 757 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 814
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLN 1379
A+ H H +++ +LL +GA++ TD LH A+ G + ++L + +
Sbjct: 815 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 874
Query: 1380 CAPIWFAASENHND-VLEYL 1398
P+ AA E+++D VL +L
Sbjct: 875 DTPLHIAARESYHDCVLLFL 894
Score = 52.4 bits (120), Expect = 2e-05
Identities = 46/192 (23%), Positives = 81/192 (42%), Gaps = 3/192 (1%)
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGK-TGLHIASTHGHYQMVEVLLGQGAEINA 1341
L+L+ G + V L+L + + +D+ K T LH A+ G ++ VLL GA INA
Sbjct: 677 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 736
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
DK TPL A HL V + + + G S+ + AA + +++ LL
Sbjct: 737 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 796
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKER 1461
+ D + ++ + H +I + +L A V NI ++ ++
Sbjct: 797 GQVDVNAQDSGG--WTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 854
Query: 1462 AKDLIAAGKQCE 1473
A + +C+
Sbjct: 855 AIAEVLLNARCD 866
Score = 50.0 bits (114), Expect = 9e-05
Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 2/156 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L L+V+ G V +L ++ + T LH AA++ V++ +L+ GA ++A
Sbjct: 677 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 736
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED-RTPMHLAAENGHAAIIELLAD 185
+ +TPL A + +Y R + ED T +H AA+ G+ ++ LL
Sbjct: 737 VDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 795
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + + G T + A+ + H + ML +G
Sbjct: 796 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 831
Score = 49.6 bits (113), Expect = 1e-04
Identities = 41/159 (25%), Positives = 68/159 (42%), Gaps = 4/159 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + GN MV LLS + + A G T + AA + +++ R+L+ GA
Sbjct: 774 GSTCLHHAAKIGNLEMVSLLLSTGQVD-VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGA 832
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
V T+ LH A+ G + + R + + TP+H+AA E+ H ++
Sbjct: 833 DVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 892
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L+ + R K+G T + A+ L +K
Sbjct: 893 FLSRGANPEL--RNKEGDTAWDLTPERSDVWFALQLNRK 929
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 712 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 771
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
+ T LH AA+I + + +L+L N G TP+ AA+ ++ + +LL
Sbjct: 772 -EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 830
Query: 787 GGD 789
G D
Sbjct: 831 GAD 833
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 710 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 767
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 768 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 797
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 808 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 865
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 866 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 925
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 926 LNRKLRLGVGNR 937
Score = 36.7 bits (81), Expect = 0.89
Identities = 63/272 (23%), Positives = 114/272 (41%), Gaps = 39/272 (14%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLATLVLLLEDGGDPL 791
L+++ + + K LMLL + PN ++ TP+H AA+ G++ +LL+ G +
Sbjct: 677 LYLSVKQGELQKVILMLLDN-LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 735
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
K TPL A + ++ R++++ +G V + +EDG++ L
Sbjct: 736 AVDK-------QQRTPLMEAVVNNHLEVARYMVQ-----RGGCVYSK-----EEDGSTCL 778
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENG-ADVSLQTRHNHETAFHYCAIAGNNDVMTEMI 910
H+A K+ + ++V L+ G DV+ Q T + A + +V+ ++
Sbjct: 779 HHAAKI---------GNLEMVSLLLSTGQVDVNAQDSGGW-TPIIWAAEHKHIEVIRMLL 828
Query: 911 AHISTADVSRALNRQN-SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
ADV+ N +N + W A G + LL + + G + LH+A
Sbjct: 829 TR--GADVTLTDNEENICLHW-----ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 881
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A Y L+ A + + G TA L
Sbjct: 882 ARESYHDCVLLFLSRGANPELRNKEGDTAWDL 913
>AL662834-27|CAI17747.2| 1176|Homo sapiens euchromatic histone-lysine
N-methyltransferase 2 protein.
Length = 1176
Score = 105 bits (251), Expect = 2e-21
Identities = 82/277 (29%), Positives = 133/277 (48%), Gaps = 6/277 (2%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH-NAMI 1022
SA+ L G + AL+ ++ K R L+L+ G V ++ D+ +
Sbjct: 585 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 644
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++
Sbjct: 645 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YM 703
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
Q V + +DG+TC H AA G+++++ L+ + V +A++ TP+ AAE
Sbjct: 704 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQDS-GGWTPIIWAAEH 761
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
H +V+R+L+ GA T + +H A+ G + +V+ + + G TPL
Sbjct: 762 KHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPL 821
Query: 1203 HIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
HIAA + V LS P E T L P
Sbjct: 822 HIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 858
Score = 91.1 bits (216), Expect = 4e-17
Identities = 65/213 (30%), Positives = 108/213 (50%), Gaps = 6/213 (2%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 652 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 710
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
T LH AA G +E+ LLL G +++A D G PI AA++ + EV+++
Sbjct: 711 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 770
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L + ++ + T + N C H A+ GS + E L+ + + A N D TPL +AA
Sbjct: 771 LTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGD-TPLHIAAR 826
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ D V + + GA+ N+ G TA L E
Sbjct: 827 ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 859
Score = 81.4 bits (192), Expect = 3e-14
Identities = 76/249 (30%), Positives = 113/249 (45%), Gaps = 18/249 (7%)
Query: 1101 HIAAIQGSV-KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
+++ QG + KVI LM D ++ + TPL AA+ G ++ VL++AGA+
Sbjct: 621 YLSVKQGELQKVI--LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 678
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
++ T + A + H V M S ++ G T LH AA G E V LLS
Sbjct: 679 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 738
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G V A G TP+ AA + + V+R+LL + G NE
Sbjct: 739 --TGQVDVNAQDS----------GGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEEN 785
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
LH A F G +I +LL+ +L H+ + HG T LHIA+ ++ V + L +GA
Sbjct: 786 IC-LHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 843
Query: 1340 NATDKNGWT 1348
+K G T
Sbjct: 844 ELRNKEGDT 852
Score = 79.4 bits (187), Expect = 1e-13
Identities = 50/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+S TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 649 QSKRTPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQR 706
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLN 1360
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+ AA+ H+
Sbjct: 707 GG-CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIE 765
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
V+++L GA N + +A+ + E LL+ D ++
Sbjct: 766 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 813
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/207 (30%), Positives = 96/207 (46%), Gaps = 15/207 (7%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 653 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 711
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
S+ E G T LH AA GN +V LLL++ V +A + G+ P+ A
Sbjct: 712 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA-QDSGGWTPIIWA 758
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
H+ ++ +LL+R A++ TD LH AS G + EVLL +++A + +G
Sbjct: 759 AEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 817
Query: 1347 WTPLHCAAKAGHLNVVKLLCESGASPK 1373
TPLH AA+ + + V L GA+P+
Sbjct: 818 DTPLHIAARESYHDCVLLFLSRGANPE 844
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL A +G +++ + LL A ++ D + R+ L A + +L+V ++ + S
Sbjct: 653 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 712
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K +G T LH AA G +V L+ ++ TP+ AA IEV ++LL
Sbjct: 713 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 772
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
GA++ TD +H A+ + + ++ L +L A G+T HIAA +
Sbjct: 773 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHD 831
Query: 1111 VIEELMKFDRTGVISARNKLNDS 1133
+ L+ R RNK D+
Sbjct: 832 CV--LLFLSRGANPELRNKEGDT 852
Score = 69.3 bits (162), Expect = 1e-10
Identities = 67/253 (26%), Positives = 117/253 (46%), Gaps = 31/253 (12%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++++ K G L ++L+L D DP ++ D + TPL A + +I L++
Sbjct: 620 LYLSVKQGELQKVILMLLDNLDPNFQS-----DQQSKRTPLHAAAQKGSVEICHVLLQ-- 672
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A I+AVD+ + L A + +V + +++ G V
Sbjct: 673 --------AGANINAVDKQQRTPLMEA---------VVNNHLEVARYMVQRGGCV-YSKE 714
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
+ T H+ A GN ++++ ++ ST V +N Q+S GWTP++ A H++++
Sbjct: 715 EDGSTCLHHAAKIGNLEMVSLLL---STGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRM 769
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY 1007
LLT A V + D E LH A+ G + + LL + +++ +G T LH+AA Y
Sbjct: 770 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 829
Query: 1008 AHLV-KFLIRDHN 1019
V FL R N
Sbjct: 830 HDCVLLFLSRGAN 842
Score = 67.7 bits (158), Expect = 4e-10
Identities = 46/172 (26%), Positives = 84/172 (48%), Gaps = 4/172 (2%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 680 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 737
Query: 119 DYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
G V V+A + G TP+ AA +++ A+ + DNE+ +H A+ G A
Sbjct: 738 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 797
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
AI E+L + + + G T +HIA+ + DC ++ +G + NK
Sbjct: 798 AIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 848
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 758 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 816
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 817 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 875
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 876 GVGNRAIRTEKIICRDVARGYENVPIPC 903
Score = 64.1 bits (149), Expect = 5e-09
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 16/200 (8%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 653 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 699
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
R ++ G + E+G LH A G++ +V LLLS +++ D G T +
Sbjct: 700 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 757
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLN 1379
A+ H H +++ +LL +GA++ TD LH A+ G + ++L + +
Sbjct: 758 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 817
Query: 1380 CAPIWFAASENHND-VLEYL 1398
P+ AA E+++D VL +L
Sbjct: 818 DTPLHIAARESYHDCVLLFL 837
Score = 52.4 bits (120), Expect = 2e-05
Identities = 46/192 (23%), Positives = 81/192 (42%), Gaps = 3/192 (1%)
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGK-TGLHIASTHGHYQMVEVLLGQGAEINA 1341
L+L+ G + V L+L + + +D+ K T LH A+ G ++ VLL GA INA
Sbjct: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
DK TPL A HL V + + + G S+ + AA + +++ LL
Sbjct: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKER 1461
+ D + ++ + H +I + +L A V NI ++ ++
Sbjct: 740 GQVDVNAQDSGG--WTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 797
Query: 1462 AKDLIAAGKQCE 1473
A + +C+
Sbjct: 798 AIAEVLLNARCD 809
Score = 50.0 bits (114), Expect = 9e-05
Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 2/156 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L L+V+ G V +L ++ + T LH AA++ V++ +L+ GA ++A
Sbjct: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED-RTPMHLAAENGHAAIIELLAD 185
+ +TPL A + +Y R + ED T +H AA+ G+ ++ LL
Sbjct: 680 VDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 738
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + + G T + A+ + H + ML +G
Sbjct: 739 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 774
Score = 49.6 bits (113), Expect = 1e-04
Identities = 41/159 (25%), Positives = 68/159 (42%), Gaps = 4/159 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + GN MV LLS + + A G T + AA + +++ R+L+ GA
Sbjct: 717 GSTCLHHAAKIGNLEMVSLLLSTGQVD-VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGA 775
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
V T+ LH A+ G + + R + + TP+H+AA E+ H ++
Sbjct: 776 DVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 835
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L+ + R K+G T + A+ L +K
Sbjct: 836 FLSRGANPEL--RNKEGDTAWDLTPERSDVWFALQLNRK 872
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 655 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 714
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
+ T LH AA+I + + +L+L N G TP+ AA+ ++ + +LL
Sbjct: 715 -EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 773
Query: 787 GGD 789
G D
Sbjct: 774 GAD 776
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 653 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 710
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 711 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 740
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 751 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 808
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 809 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 868
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 869 LNRKLRLGVGNR 880
Score = 36.7 bits (81), Expect = 0.89
Identities = 63/272 (23%), Positives = 114/272 (41%), Gaps = 39/272 (14%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLATLVLLLEDGGDPL 791
L+++ + + K LMLL + PN ++ TP+H AA+ G++ +LL+ G +
Sbjct: 620 LYLSVKQGELQKVILMLLDN-LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 678
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
K TPL A + ++ R++++ +G V + +EDG++ L
Sbjct: 679 AVDK-------QQRTPLMEAVVNNHLEVARYMVQ-----RGGCVYSK-----EEDGSTCL 721
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENG-ADVSLQTRHNHETAFHYCAIAGNNDVMTEMI 910
H+A K+ + ++V L+ G DV+ Q T + A + +V+ ++
Sbjct: 722 HHAAKI---------GNLEMVSLLLSTGQVDVNAQDSGGW-TPIIWAAEHKHIEVIRMLL 771
Query: 911 AHISTADVSRALNRQN-SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
ADV+ N +N + W A G + LL + + G + LH+A
Sbjct: 772 TR--GADVTLTDNEENICLHW-----ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 824
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A Y L+ A + + G TA L
Sbjct: 825 ARESYHDCVLLFLSRGANPELRNKEGDTAWDL 856
>AL662834-26|CAI17748.1| 1210|Homo sapiens euchromatic histone-lysine
N-methyltransferase 2 protein.
Length = 1210
Score = 105 bits (251), Expect = 2e-21
Identities = 82/277 (29%), Positives = 133/277 (48%), Gaps = 6/277 (2%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH-NAMI 1022
SA+ L G + AL+ ++ K R L+L+ G V ++ D+ +
Sbjct: 619 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 678
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++
Sbjct: 679 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YM 737
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
Q V + +DG+TC H AA G+++++ L+ + V +A++ TP+ AAE
Sbjct: 738 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQDS-GGWTPIIWAAEH 795
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
H +V+R+L+ GA T + +H A+ G + +V+ + + G TPL
Sbjct: 796 KHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPL 855
Query: 1203 HIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
HIAA + V LS P E T L P
Sbjct: 856 HIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 892
Score = 91.1 bits (216), Expect = 4e-17
Identities = 65/213 (30%), Positives = 108/213 (50%), Gaps = 6/213 (2%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 686 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 744
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
T LH AA G +E+ LLL G +++A D G PI AA++ + EV+++
Sbjct: 745 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 804
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L + ++ + T + N C H A+ GS + E L+ + + A N D TPL +AA
Sbjct: 805 LTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGD-TPLHIAAR 860
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ D V + + GA+ N+ G TA L E
Sbjct: 861 ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
Score = 81.4 bits (192), Expect = 3e-14
Identities = 76/249 (30%), Positives = 113/249 (45%), Gaps = 18/249 (7%)
Query: 1101 HIAAIQGSV-KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
+++ QG + KVI LM D ++ + TPL AA+ G ++ VL++AGA+
Sbjct: 655 YLSVKQGELQKVI--LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 712
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
++ T + A + H V M S ++ G T LH AA G E V LLS
Sbjct: 713 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 772
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G V A G TP+ AA + + V+R+LL + G NE
Sbjct: 773 --TGQVDVNAQDS----------GGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEEN 819
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
LH A F G +I +LL+ +L H+ + HG T LHIA+ ++ V + L +GA
Sbjct: 820 IC-LHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 877
Query: 1340 NATDKNGWT 1348
+K G T
Sbjct: 878 ELRNKEGDT 886
Score = 79.4 bits (187), Expect = 1e-13
Identities = 50/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+S TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 683 QSKRTPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQR 740
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLN 1360
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+ AA+ H+
Sbjct: 741 GG-CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIE 799
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
V+++L GA N + +A+ + E LL+ D ++
Sbjct: 800 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 847
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/207 (30%), Positives = 96/207 (46%), Gaps = 15/207 (7%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 687 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 745
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
S+ E G T LH AA GN +V LLL++ V +A + G+ P+ A
Sbjct: 746 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA-QDSGGWTPIIWA 792
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
H+ ++ +LL+R A++ TD LH AS G + EVLL +++A + +G
Sbjct: 793 AEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 851
Query: 1347 WTPLHCAAKAGHLNVVKLLCESGASPK 1373
TPLH AA+ + + V L GA+P+
Sbjct: 852 DTPLHIAARESYHDCVLLFLSRGANPE 878
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL A +G +++ + LL A ++ D + R+ L A + +L+V ++ + S
Sbjct: 687 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 746
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K +G T LH AA G +V L+ ++ TP+ AA IEV ++LL
Sbjct: 747 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 806
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
GA++ TD +H A+ + + ++ L +L A G+T HIAA +
Sbjct: 807 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHD 865
Query: 1111 VIEELMKFDRTGVISARNKLNDS 1133
+ L+ R RNK D+
Sbjct: 866 CV--LLFLSRGANPELRNKEGDT 886
Score = 69.3 bits (162), Expect = 1e-10
Identities = 67/253 (26%), Positives = 117/253 (46%), Gaps = 31/253 (12%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++++ K G L ++L+L D DP ++ D + TPL A + +I L++
Sbjct: 654 LYLSVKQGELQKVILMLLDNLDPNFQS-----DQQSKRTPLHAAAQKGSVEICHVLLQ-- 706
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A I+AVD+ + L A + +V + +++ G V
Sbjct: 707 --------AGANINAVDKQQRTPLMEA---------VVNNHLEVARYMVQRGGCV-YSKE 748
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
+ T H+ A GN ++++ ++ ST V +N Q+S GWTP++ A H++++
Sbjct: 749 EDGSTCLHHAAKIGNLEMVSLLL---STGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRM 803
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY 1007
LLT A V + D E LH A+ G + + LL + +++ +G T LH+AA Y
Sbjct: 804 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 863
Query: 1008 AHLV-KFLIRDHN 1019
V FL R N
Sbjct: 864 HDCVLLFLSRGAN 876
Score = 67.7 bits (158), Expect = 4e-10
Identities = 46/172 (26%), Positives = 84/172 (48%), Gaps = 4/172 (2%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 714 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 771
Query: 119 DYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
G V V+A + G TP+ AA +++ A+ + DNE+ +H A+ G A
Sbjct: 772 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 831
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
AI E+L + + + G T +HIA+ + DC ++ +G + NK
Sbjct: 832 AIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 882
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 792 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 850
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 851 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 909
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 910 GVGNRAIRTEKIICRDVARGYENVPIPC 937
Score = 64.1 bits (149), Expect = 5e-09
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 16/200 (8%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 687 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 733
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
R ++ G + E+G LH A G++ +V LLLS +++ D G T +
Sbjct: 734 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 791
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLN 1379
A+ H H +++ +LL +GA++ TD LH A+ G + ++L + +
Sbjct: 792 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 851
Query: 1380 CAPIWFAASENHND-VLEYL 1398
P+ AA E+++D VL +L
Sbjct: 852 DTPLHIAARESYHDCVLLFL 871
Score = 52.4 bits (120), Expect = 2e-05
Identities = 46/192 (23%), Positives = 81/192 (42%), Gaps = 3/192 (1%)
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGK-TGLHIASTHGHYQMVEVLLGQGAEINA 1341
L+L+ G + V L+L + + +D+ K T LH A+ G ++ VLL GA INA
Sbjct: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
DK TPL A HL V + + + G S+ + AA + +++ LL
Sbjct: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKER 1461
+ D + ++ + H +I + +L A V NI ++ ++
Sbjct: 774 GQVDVNAQDSGG--WTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 831
Query: 1462 AKDLIAAGKQCE 1473
A + +C+
Sbjct: 832 AIAEVLLNARCD 843
Score = 50.0 bits (114), Expect = 9e-05
Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 2/156 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L L+V+ G V +L ++ + T LH AA++ V++ +L+ GA ++A
Sbjct: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED-RTPMHLAAENGHAAIIELLAD 185
+ +TPL A + +Y R + ED T +H AA+ G+ ++ LL
Sbjct: 714 VDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 772
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + + G T + A+ + H + ML +G
Sbjct: 773 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 808
Score = 49.6 bits (113), Expect = 1e-04
Identities = 41/159 (25%), Positives = 68/159 (42%), Gaps = 4/159 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + GN MV LLS + + A G T + AA + +++ R+L+ GA
Sbjct: 751 GSTCLHHAAKIGNLEMVSLLLSTGQVD-VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGA 809
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
V T+ LH A+ G + + R + + TP+H+AA E+ H ++
Sbjct: 810 DVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 869
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L+ + R K+G T + A+ L +K
Sbjct: 870 FLSRGANPEL--RNKEGDTAWDLTPERSDVWFALQLNRK 906
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 689 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 748
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
+ T LH AA+I + + +L+L N G TP+ AA+ ++ + +LL
Sbjct: 749 -EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807
Query: 787 GGD 789
G D
Sbjct: 808 GAD 810
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 687 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 744
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 745 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 774
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 785 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 842
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 843 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 902
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 903 LNRKLRLGVGNR 914
Score = 36.7 bits (81), Expect = 0.89
Identities = 63/272 (23%), Positives = 114/272 (41%), Gaps = 39/272 (14%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLATLVLLLEDGGDPL 791
L+++ + + K LMLL + PN ++ TP+H AA+ G++ +LL+ G +
Sbjct: 654 LYLSVKQGELQKVILMLLDN-LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 712
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
K TPL A + ++ R++++ +G V + +EDG++ L
Sbjct: 713 AVDK-------QQRTPLMEAVVNNHLEVARYMVQ-----RGGCVYSK-----EEDGSTCL 755
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENG-ADVSLQTRHNHETAFHYCAIAGNNDVMTEMI 910
H+A K+ + ++V L+ G DV+ Q T + A + +V+ ++
Sbjct: 756 HHAAKI---------GNLEMVSLLLSTGQVDVNAQDSGGW-TPIIWAAEHKHIEVIRMLL 805
Query: 911 AHISTADVSRALNRQN-SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
ADV+ N +N + W A G + LL + + G + LH+A
Sbjct: 806 TR--GADVTLTDNEENICLHW-----ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 858
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A Y L+ A + + G TA L
Sbjct: 859 ARESYHDCVLLFLSRGANPELRNKEGDTAWDL 890
>AL662834-25|CAM24993.1| 1267|Homo sapiens euchromatic histone-lysine
N-methyltransferase 2 protein.
Length = 1267
Score = 105 bits (251), Expect = 2e-21
Identities = 82/277 (29%), Positives = 133/277 (48%), Gaps = 6/277 (2%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH-NAMI 1022
SA+ L G + AL+ ++ K R L+L+ G V ++ D+ +
Sbjct: 676 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 735
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++
Sbjct: 736 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YM 794
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
Q V + +DG+TC H AA G+++++ L+ + V +A++ TP+ AAE
Sbjct: 795 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQDS-GGWTPIIWAAEH 852
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
H +V+R+L+ GA T + +H A+ G + +V+ + + G TPL
Sbjct: 853 KHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPL 912
Query: 1203 HIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
HIAA + V LS P E T L P
Sbjct: 913 HIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 949
Score = 91.1 bits (216), Expect = 4e-17
Identities = 65/213 (30%), Positives = 108/213 (50%), Gaps = 6/213 (2%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 743 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 801
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
T LH AA G +E+ LLL G +++A D G PI AA++ + EV+++
Sbjct: 802 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 861
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L + ++ + T + N C H A+ GS + E L+ + + A N D TPL +AA
Sbjct: 862 LTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGD-TPLHIAAR 917
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ D V + + GA+ N+ G TA L E
Sbjct: 918 ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 950
Score = 81.4 bits (192), Expect = 3e-14
Identities = 76/249 (30%), Positives = 113/249 (45%), Gaps = 18/249 (7%)
Query: 1101 HIAAIQGSV-KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
+++ QG + KVI LM D ++ + TPL AA+ G ++ VL++AGA+
Sbjct: 712 YLSVKQGELQKVI--LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 769
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
++ T + A + H V M S ++ G T LH AA G E V LLS
Sbjct: 770 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 829
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G V A G TP+ AA + + V+R+LL + G NE
Sbjct: 830 --TGQVDVNAQDS----------GGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEEN 876
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
LH A F G +I +LL+ +L H+ + HG T LHIA+ ++ V + L +GA
Sbjct: 877 IC-LHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 934
Query: 1340 NATDKNGWT 1348
+K G T
Sbjct: 935 ELRNKEGDT 943
Score = 79.4 bits (187), Expect = 1e-13
Identities = 50/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+S TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 740 QSKRTPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQR 797
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLN 1360
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+ AA+ H+
Sbjct: 798 GG-CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIE 856
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
V+++L GA N + +A+ + E LL+ D ++
Sbjct: 857 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 904
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/207 (30%), Positives = 96/207 (46%), Gaps = 15/207 (7%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 744 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 802
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
S+ E G T LH AA GN +V LLL++ V +A + G+ P+ A
Sbjct: 803 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA-QDSGGWTPIIWA 849
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
H+ ++ +LL+R A++ TD LH AS G + EVLL +++A + +G
Sbjct: 850 AEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 908
Query: 1347 WTPLHCAAKAGHLNVVKLLCESGASPK 1373
TPLH AA+ + + V L GA+P+
Sbjct: 909 DTPLHIAARESYHDCVLLFLSRGANPE 935
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL A +G +++ + LL A ++ D + R+ L A + +L+V ++ + S
Sbjct: 744 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 803
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K +G T LH AA G +V L+ ++ TP+ AA IEV ++LL
Sbjct: 804 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 863
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
GA++ TD +H A+ + + ++ L +L A G+T HIAA +
Sbjct: 864 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHD 922
Query: 1111 VIEELMKFDRTGVISARNKLNDS 1133
+ L+ R RNK D+
Sbjct: 923 CV--LLFLSRGANPELRNKEGDT 943
Score = 69.3 bits (162), Expect = 1e-10
Identities = 67/253 (26%), Positives = 117/253 (46%), Gaps = 31/253 (12%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++++ K G L ++L+L D DP ++ D + TPL A + +I L++
Sbjct: 711 LYLSVKQGELQKVILMLLDNLDPNFQS-----DQQSKRTPLHAAAQKGSVEICHVLLQ-- 763
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A I+AVD+ + L A + +V + +++ G V
Sbjct: 764 --------AGANINAVDKQQRTPLMEA---------VVNNHLEVARYMVQRGGCV-YSKE 805
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
+ T H+ A GN ++++ ++ ST V +N Q+S GWTP++ A H++++
Sbjct: 806 EDGSTCLHHAAKIGNLEMVSLLL---STGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRM 860
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY 1007
LLT A V + D E LH A+ G + + LL + +++ +G T LH+AA Y
Sbjct: 861 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 920
Query: 1008 AHLV-KFLIRDHN 1019
V FL R N
Sbjct: 921 HDCVLLFLSRGAN 933
Score = 67.7 bits (158), Expect = 4e-10
Identities = 46/172 (26%), Positives = 84/172 (48%), Gaps = 4/172 (2%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 771 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 828
Query: 119 DYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
G V V+A + G TP+ AA +++ A+ + DNE+ +H A+ G A
Sbjct: 829 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 888
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
AI E+L + + + G T +HIA+ + DC ++ +G + NK
Sbjct: 889 AIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 939
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 849 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 907
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 908 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 966
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 967 GVGNRAIRTEKIICRDVARGYENVPIPC 994
Score = 64.1 bits (149), Expect = 5e-09
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 16/200 (8%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 744 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 790
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
R ++ G + E+G LH A G++ +V LLLS +++ D G T +
Sbjct: 791 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 848
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLN 1379
A+ H H +++ +LL +GA++ TD LH A+ G + ++L + +
Sbjct: 849 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 908
Query: 1380 CAPIWFAASENHND-VLEYL 1398
P+ AA E+++D VL +L
Sbjct: 909 DTPLHIAARESYHDCVLLFL 928
Score = 52.4 bits (120), Expect = 2e-05
Identities = 46/192 (23%), Positives = 81/192 (42%), Gaps = 3/192 (1%)
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGK-TGLHIASTHGHYQMVEVLLGQGAEINA 1341
L+L+ G + V L+L + + +D+ K T LH A+ G ++ VLL GA INA
Sbjct: 711 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 770
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
DK TPL A HL V + + + G S+ + AA + +++ LL
Sbjct: 771 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 830
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKER 1461
+ D + ++ + H +I + +L A V NI ++ ++
Sbjct: 831 GQVDVNAQDSGG--WTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 888
Query: 1462 AKDLIAAGKQCE 1473
A + +C+
Sbjct: 889 AIAEVLLNARCD 900
Score = 50.0 bits (114), Expect = 9e-05
Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 2/156 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L L+V+ G V +L ++ + T LH AA++ V++ +L+ GA ++A
Sbjct: 711 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 770
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED-RTPMHLAAENGHAAIIELLAD 185
+ +TPL A + +Y R + ED T +H AA+ G+ ++ LL
Sbjct: 771 VDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 829
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + + G T + A+ + H + ML +G
Sbjct: 830 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 865
Score = 49.6 bits (113), Expect = 1e-04
Identities = 41/159 (25%), Positives = 68/159 (42%), Gaps = 4/159 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + GN MV LLS + + A G T + AA + +++ R+L+ GA
Sbjct: 808 GSTCLHHAAKIGNLEMVSLLLSTGQVD-VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGA 866
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
V T+ LH A+ G + + R + + TP+H+AA E+ H ++
Sbjct: 867 DVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 926
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L+ + R K+G T + A+ L +K
Sbjct: 927 FLSRGANPEL--RNKEGDTAWDLTPERSDVWFALQLNRK 963
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 746 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 805
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
+ T LH AA+I + + +L+L N G TP+ AA+ ++ + +LL
Sbjct: 806 -EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 864
Query: 787 GGD 789
G D
Sbjct: 865 GAD 867
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 744 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 801
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 802 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 831
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 842 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 899
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 900 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 959
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 960 LNRKLRLGVGNR 971
Score = 36.7 bits (81), Expect = 0.89
Identities = 63/272 (23%), Positives = 114/272 (41%), Gaps = 39/272 (14%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLATLVLLLEDGGDPL 791
L+++ + + K LMLL + PN ++ TP+H AA+ G++ +LL+ G +
Sbjct: 711 LYLSVKQGELQKVILMLLDN-LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 769
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
K TPL A + ++ R++++ +G V + +EDG++ L
Sbjct: 770 AVDK-------QQRTPLMEAVVNNHLEVARYMVQ-----RGGCVYSK-----EEDGSTCL 812
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENG-ADVSLQTRHNHETAFHYCAIAGNNDVMTEMI 910
H+A K+ + ++V L+ G DV+ Q T + A + +V+ ++
Sbjct: 813 HHAAKI---------GNLEMVSLLLSTGQVDVNAQDSGGW-TPIIWAAEHKHIEVIRMLL 862
Query: 911 AHISTADVSRALNRQN-SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
ADV+ N +N + W A G + LL + + G + LH+A
Sbjct: 863 TR--GADVTLTDNEENICLHW-----ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 915
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A Y L+ A + + G TA L
Sbjct: 916 ARESYHDCVLLFLSRGANPELRNKEGDTAWDL 947
>AL662834-24|CAM24992.1| 1233|Homo sapiens euchromatic histone-lysine
N-methyltransferase 2 protein.
Length = 1233
Score = 105 bits (251), Expect = 2e-21
Identities = 82/277 (29%), Positives = 133/277 (48%), Gaps = 6/277 (2%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH-NAMI 1022
SA+ L G + AL+ ++ K R L+L+ G V ++ D+ +
Sbjct: 642 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 701
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++
Sbjct: 702 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YM 760
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
Q V + +DG+TC H AA G+++++ L+ + V +A++ TP+ AAE
Sbjct: 761 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQDS-GGWTPIIWAAEH 818
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
H +V+R+L+ GA T + +H A+ G + +V+ + + G TPL
Sbjct: 819 KHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPL 878
Query: 1203 HIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
HIAA + V LS P E T L P
Sbjct: 879 HIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 915
Score = 91.1 bits (216), Expect = 4e-17
Identities = 65/213 (30%), Positives = 108/213 (50%), Gaps = 6/213 (2%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 709 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 767
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
T LH AA G +E+ LLL G +++A D G PI AA++ + EV+++
Sbjct: 768 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 827
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L + ++ + T + N C H A+ GS + E L+ + + A N D TPL +AA
Sbjct: 828 LTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGD-TPLHIAAR 883
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ D V + + GA+ N+ G TA L E
Sbjct: 884 ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 916
Score = 81.4 bits (192), Expect = 3e-14
Identities = 76/249 (30%), Positives = 113/249 (45%), Gaps = 18/249 (7%)
Query: 1101 HIAAIQGSV-KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
+++ QG + KVI LM D ++ + TPL AA+ G ++ VL++AGA+
Sbjct: 678 YLSVKQGELQKVI--LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 735
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
++ T + A + H V M S ++ G T LH AA G E V LLS
Sbjct: 736 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 795
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G V A G TP+ AA + + V+R+LL + G NE
Sbjct: 796 --TGQVDVNAQDS----------GGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEEN 842
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
LH A F G +I +LL+ +L H+ + HG T LHIA+ ++ V + L +GA
Sbjct: 843 IC-LHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 900
Query: 1340 NATDKNGWT 1348
+K G T
Sbjct: 901 ELRNKEGDT 909
Score = 79.4 bits (187), Expect = 1e-13
Identities = 50/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+S TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 706 QSKRTPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQR 763
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLN 1360
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+ AA+ H+
Sbjct: 764 GG-CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIE 822
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
V+++L GA N + +A+ + E LL+ D ++
Sbjct: 823 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 870
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/207 (30%), Positives = 96/207 (46%), Gaps = 15/207 (7%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 710 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 768
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
S+ E G T LH AA GN +V LLL++ V +A + G+ P+ A
Sbjct: 769 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA-QDSGGWTPIIWA 815
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
H+ ++ +LL+R A++ TD LH AS G + EVLL +++A + +G
Sbjct: 816 AEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 874
Query: 1347 WTPLHCAAKAGHLNVVKLLCESGASPK 1373
TPLH AA+ + + V L GA+P+
Sbjct: 875 DTPLHIAARESYHDCVLLFLSRGANPE 901
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL A +G +++ + LL A ++ D + R+ L A + +L+V ++ + S
Sbjct: 710 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 769
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K +G T LH AA G +V L+ ++ TP+ AA IEV ++LL
Sbjct: 770 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 829
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
GA++ TD +H A+ + + ++ L +L A G+T HIAA +
Sbjct: 830 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHD 888
Query: 1111 VIEELMKFDRTGVISARNKLNDS 1133
+ L+ R RNK D+
Sbjct: 889 CV--LLFLSRGANPELRNKEGDT 909
Score = 69.3 bits (162), Expect = 1e-10
Identities = 67/253 (26%), Positives = 117/253 (46%), Gaps = 31/253 (12%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++++ K G L ++L+L D DP ++ D + TPL A + +I L++
Sbjct: 677 LYLSVKQGELQKVILMLLDNLDPNFQS-----DQQSKRTPLHAAAQKGSVEICHVLLQ-- 729
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A I+AVD+ + L A + +V + +++ G V
Sbjct: 730 --------AGANINAVDKQQRTPLMEA---------VVNNHLEVARYMVQRGGCV-YSKE 771
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
+ T H+ A GN ++++ ++ ST V +N Q+S GWTP++ A H++++
Sbjct: 772 EDGSTCLHHAAKIGNLEMVSLLL---STGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRM 826
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY 1007
LLT A V + D E LH A+ G + + LL + +++ +G T LH+AA Y
Sbjct: 827 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 886
Query: 1008 AHLV-KFLIRDHN 1019
V FL R N
Sbjct: 887 HDCVLLFLSRGAN 899
Score = 67.7 bits (158), Expect = 4e-10
Identities = 46/172 (26%), Positives = 84/172 (48%), Gaps = 4/172 (2%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 737 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 794
Query: 119 DYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
G V V+A + G TP+ AA +++ A+ + DNE+ +H A+ G A
Sbjct: 795 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 854
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
AI E+L + + + G T +HIA+ + DC ++ +G + NK
Sbjct: 855 AIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 905
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 815 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 873
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 874 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 932
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 933 GVGNRAIRTEKIICRDVARGYENVPIPC 960
Score = 64.1 bits (149), Expect = 5e-09
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 16/200 (8%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 710 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 756
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
R ++ G + E+G LH A G++ +V LLLS +++ D G T +
Sbjct: 757 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 814
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLN 1379
A+ H H +++ +LL +GA++ TD LH A+ G + ++L + +
Sbjct: 815 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 874
Query: 1380 CAPIWFAASENHND-VLEYL 1398
P+ AA E+++D VL +L
Sbjct: 875 DTPLHIAARESYHDCVLLFL 894
Score = 52.4 bits (120), Expect = 2e-05
Identities = 46/192 (23%), Positives = 81/192 (42%), Gaps = 3/192 (1%)
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGK-TGLHIASTHGHYQMVEVLLGQGAEINA 1341
L+L+ G + V L+L + + +D+ K T LH A+ G ++ VLL GA INA
Sbjct: 677 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 736
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
DK TPL A HL V + + + G S+ + AA + +++ LL
Sbjct: 737 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 796
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKER 1461
+ D + ++ + H +I + +L A V NI ++ ++
Sbjct: 797 GQVDVNAQDSGG--WTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 854
Query: 1462 AKDLIAAGKQCE 1473
A + +C+
Sbjct: 855 AIAEVLLNARCD 866
Score = 50.0 bits (114), Expect = 9e-05
Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 2/156 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L L+V+ G V +L ++ + T LH AA++ V++ +L+ GA ++A
Sbjct: 677 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 736
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED-RTPMHLAAENGHAAIIELLAD 185
+ +TPL A + +Y R + ED T +H AA+ G+ ++ LL
Sbjct: 737 VDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 795
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + + G T + A+ + H + ML +G
Sbjct: 796 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 831
Score = 49.6 bits (113), Expect = 1e-04
Identities = 41/159 (25%), Positives = 68/159 (42%), Gaps = 4/159 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + GN MV LLS + + A G T + AA + +++ R+L+ GA
Sbjct: 774 GSTCLHHAAKIGNLEMVSLLLSTGQVD-VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGA 832
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
V T+ LH A+ G + + R + + TP+H+AA E+ H ++
Sbjct: 833 DVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 892
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L+ + R K+G T + A+ L +K
Sbjct: 893 FLSRGANPEL--RNKEGDTAWDLTPERSDVWFALQLNRK 929
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 712 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 771
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
+ T LH AA+I + + +L+L N G TP+ AA+ ++ + +LL
Sbjct: 772 -EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 830
Query: 787 GGD 789
G D
Sbjct: 831 GAD 833
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 710 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 767
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 768 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 797
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 808 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 865
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 866 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 925
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 926 LNRKLRLGVGNR 937
Score = 36.7 bits (81), Expect = 0.89
Identities = 63/272 (23%), Positives = 114/272 (41%), Gaps = 39/272 (14%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLATLVLLLEDGGDPL 791
L+++ + + K LMLL + PN ++ TP+H AA+ G++ +LL+ G +
Sbjct: 677 LYLSVKQGELQKVILMLLDN-LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 735
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
K TPL A + ++ R++++ +G V + +EDG++ L
Sbjct: 736 AVDK-------QQRTPLMEAVVNNHLEVARYMVQ-----RGGCVYSK-----EEDGSTCL 778
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENG-ADVSLQTRHNHETAFHYCAIAGNNDVMTEMI 910
H+A K+ + ++V L+ G DV+ Q T + A + +V+ ++
Sbjct: 779 HHAAKI---------GNLEMVSLLLSTGQVDVNAQDSGGW-TPIIWAAEHKHIEVIRMLL 828
Query: 911 AHISTADVSRALNRQN-SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
ADV+ N +N + W A G + LL + + G + LH+A
Sbjct: 829 TR--GADVTLTDNEENICLHW-----ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 881
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A Y L+ A + + G TA L
Sbjct: 882 ARESYHDCVLLFLSRGANPELRNKEGDTAWDL 913
>AK222595-1|BAD96315.1| 518|Homo sapiens ankyrin repeat and SOCS
box-containing protein 3 isoform a variant protein.
Length = 518
Score = 105 bits (251), Expect = 2e-21
Identities = 84/268 (31%), Positives = 125/268 (46%), Gaps = 22/268 (8%)
Query: 1138 LAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM----RSTNTLRIS 1193
LAA G+ V+R L++ G S + G +H AA H L ++ S N +++
Sbjct: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAY 1253
+ + G LH+AA G + V+ LL P +L TPL LA
Sbjct: 76 TFE-GFCALHLAASQGHWKIVQILLE------AGADPNATTLEET-------TPLFLAVE 121
Query: 1254 NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHG 1313
NG +V+RLLL G + + + G+N LH A F + I+ LLL + A D G
Sbjct: 122 NGQIDVLRLLLQH-GANVNGSHSMCGWNSLHQASFQDNAEIIKLLLRKGANK-ECQDDFG 179
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPK 1373
T L +A+ +G + + +L+ GA +N + TPL AA+ GH V+LL SGA P
Sbjct: 180 ITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD 239
Query: 1374 SETNLNC--APIWFAASENHNDVLEYLL 1399
N + PI AA H +L+ L+
Sbjct: 240 LYCNEDSWQLPIHAAAQMGHTKILDLLI 267
Score = 95.5 bits (227), Expect = 2e-18
Identities = 72/239 (30%), Positives = 117/239 (48%), Gaps = 14/239 (5%)
Query: 1167 TAVHLAAEHGHTNVL-DVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTV 1225
+ V LAA G+ VL +++ ++ ++ + G P+H AAY+ E ++ L++
Sbjct: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNR-GWMPIHEAAYHNSVECLQMLIN------ 64
Query: 1226 KSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHL 1285
A + + + + E G LHLAA G+ +V++LL AG +A + E PL L
Sbjct: 65 ---ADSSENYIKMKTFE-GFCALHLAASQGHWKIVQILLE-AGADPNATTLEET-TPLFL 118
Query: 1286 ACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKN 1345
A G + ++ LLL A + S G LH AS + +++++LL +GA D
Sbjct: 119 AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQDNAEIIKLLLRKGANKECQDDF 178
Query: 1346 GWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G TPL AA+ G L + +L SGA+ + P++ AA E H +E LL D
Sbjct: 179 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD 237
Score = 91.9 bits (218), Expect = 2e-17
Identities = 84/315 (26%), Positives = 154/315 (48%), Gaps = 23/315 (7%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA--M 1021
S + LAA G ++V LL ++ G +H AA + ++ LI ++
Sbjct: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENY 71
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
I + T + LHLAA+ G ++ ++LLE GA+ +AT P+ A +N +V++L
Sbjct: 72 IKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLL 131
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
LQ N+ + + G H A+ Q + ++I+ L+ R G TPL +AA+
Sbjct: 132 LQHGANVNGSHSMCGWNSLHQASFQDNAEIIKLLL---RKGANKECQDDFGITPLFVAAQ 188
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT---LRISSKKLG 1198
G + + +L+ +GA+ + T + +AA+ GHT ++++ S+ L +
Sbjct: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQ 248
Query: 1199 LTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNEN 1258
L P+H AA G + + +LL +P T ++ TG++ V +P++ A + G+E+
Sbjct: 249 L-PIHAAAQMGHTK-ILDLL--IPLTNRA-CDTGLNKV---------SPVYSAVFGGHED 294
Query: 1259 VVRLLLNSAGVQADA 1273
+ +LL + G DA
Sbjct: 295 CLEILLRN-GYSPDA 308
Score = 91.1 bits (216), Expect = 4e-17
Identities = 72/271 (26%), Positives = 126/271 (46%), Gaps = 11/271 (4%)
Query: 920 RALNRQNSIGWTPLLIACHRGHMQLVNTLLT-----NHARVDVFDVEGRSALHLAAEHGY 974
R+++ ++ GW P+ A + ++ + L+ N+ ++ F EG ALHLAA G+
Sbjct: 34 RSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTF--EGFCALHLAASQGH 91
Query: 975 LQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMID-VLTLKKQTPL 1033
++ LL A N+ T L LA NG +++ L++ H A ++ ++ L
Sbjct: 92 WKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ-HGANVNGSHSMCGWNSL 150
Query: 1034 HLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT 1093
H A+ E+ KLLL GAN + D+ G P+ AAQ E + + + N V
Sbjct: 151 HQASFQDNAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGAN-VNCQA 209
Query: 1094 KDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR 1153
D T IAA +G K +E L+ + N+ + P+ AA+ GH ++ +L+
Sbjct: 210 LDKATPLFIAAQEGHTKCVELLLSSGADPDLYC-NEDSWQLPIHAAAQMGHTKILDLLIP 268
Query: 1154 AGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
D ++ V+ A GH + L+++
Sbjct: 269 LTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 299
Score = 84.6 bits (200), Expect = 3e-15
Identities = 80/312 (25%), Positives = 142/312 (45%), Gaps = 18/312 (5%)
Query: 1069 AAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
AA+ +V++ L++ ++ +A + G H AA SV+ ++ L+ D +
Sbjct: 17 AAREGNVKVLRKLLKKGRSVDVADNR-GWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTN 1188
L LAA GH +V++L+ AGA T + LA E+G +VL ++
Sbjct: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
Query: 1189 T-LRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+ S G LH A++ AE ++ LL G K + G+TP
Sbjct: 136 ANVNGSHSMCGWNSLHQASFQDNAEIIKLLLRK--GANKE-----------CQDDFGITP 182
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL-L 1306
L +AA G + +L++S G + + + PL +A GH V LLLS A+ L
Sbjct: 183 LFVAAQYGKLESLSILISS-GANVNCQALDKA-TPLFIAAQEGHTKCVELLLSSGADPDL 240
Query: 1307 HSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
+ + + +H A+ GH +++++L+ T N +P++ A GH + +++L
Sbjct: 241 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 300
Query: 1367 ESGASPKSETNL 1378
+G SP ++ L
Sbjct: 301 RNGYSPDAQACL 312
Score = 74.1 bits (174), Expect = 5e-12
Identities = 45/133 (33%), Positives = 71/133 (53%), Gaps = 1/133 (0%)
Query: 657 KYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLL 716
K K F+G ++H AA GH I+ LL+ G + TT + T L +AVE+ + V+ LL
Sbjct: 73 KMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL 132
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
+GA+V+ LH A D + +LL+ GA + G+TP+ VAA++G
Sbjct: 133 QHGANVNGSHSMCGWNSLH-QASFQDNAEIIKLLLRKGANKECQDDFGITPLFVAAQYGK 191
Query: 777 LATLVLLLEDGGD 789
L +L +L+ G +
Sbjct: 192 LESLSILISSGAN 204
Score = 59.7 bits (138), Expect = 1e-07
Identities = 45/146 (30%), Positives = 70/146 (47%), Gaps = 5/146 (3%)
Query: 654 FFEKYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVE 713
F E Y D ++ AAR G+V ++ LL+KG SVDV N + +H A ++
Sbjct: 3 FTEAYA--DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQ 60
Query: 714 TLLGYGADVHIRGGKQRE--TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVA 771
L+ + + K E LH+AA K +LL++GA PN T + TP+ +A
Sbjct: 61 MLINADSSENYIKMKTFEGFCALHLAAS-QGHWKIVQILLEAGADPNATTLEETTPLFLA 119
Query: 772 AKFGNLATLVLLLEDGGDPLRKTKVC 797
+ G + L LLL+ G + +C
Sbjct: 120 VENGQIDVLRLLLQHGANVNGSHSMC 145
Score = 58.8 bits (136), Expect = 2e-07
Identities = 42/124 (33%), Positives = 64/124 (51%), Gaps = 4/124 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G S+H A+ + II LL+KG + + + T L +A + K + L+ GA+V
Sbjct: 146 GWNSLHQASFQDNAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 205
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPN-KATEDG-MTPVHVAAKFGNLATL 780
+ + + TPL IAA+ KC +LL SGA P+ ED P+H AA+ G+ L
Sbjct: 206 NCQ-ALDKATPLFIAAQ-EGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKIL 263
Query: 781 VLLL 784
LL+
Sbjct: 264 DLLI 267
Score = 54.8 bits (126), Expect = 3e-06
Identities = 42/146 (28%), Positives = 67/146 (45%), Gaps = 2/146 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LAVE G ++R LL A + + G +LH A+ + + ++ ++L+ GA +
Sbjct: 115 PLFLAVENGQIDVLRLLLQ-HGANVNGSHSMCGWNSLHQASFQDNAEIIKLLLRKGANKE 173
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ G TPL +AA G + AN + TP+ +AA+ GH +ELL
Sbjct: 174 CQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLS 233
Query: 186 KFKASIFERTKDGSTL-MHIASLNGH 210
+D L +H A+ GH
Sbjct: 234 SGADPDLYCNEDSWQLPIHAAAQMGH 259
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/126 (30%), Positives = 61/126 (48%), Gaps = 3/126 (2%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G T L +AA+ ++ IL+ GA V+ TPL IAA EG V+ A+
Sbjct: 179 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADP 238
Query: 158 AIADNED--RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAM 215
+ NED + P+H AA+ GH I++LL + + + + ++ A GH DC
Sbjct: 239 DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRAC-DTGLNKVSPVYSAVFGGHEDCLE 297
Query: 216 MLFKKG 221
+L + G
Sbjct: 298 ILLRNG 303
Score = 52.4 bits (120), Expect = 2e-05
Identities = 42/181 (23%), Positives = 76/181 (41%), Gaps = 5/181 (2%)
Query: 69 LAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA---VVD 125
LA GN ++R+LL + + G +H AA V+ ++L++ + +
Sbjct: 16 LAAREGNVKVLRKLL--KKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIK 73
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
G LH+AA++G +V+ A+ E+ TP+ LA ENG ++ LL
Sbjct: 74 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 133
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDEVLFVKIE 245
+ G +H AS +A+ +L +KG + + F + K+E
Sbjct: 134 HGANVNGSHSMCGWNSLHQASFQDNAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 193
Query: 246 N 246
+
Sbjct: 194 S 194
Score = 48.8 bits (111), Expect = 2e-04
Identities = 36/122 (29%), Positives = 61/122 (50%), Gaps = 3/122 (2%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTND-NYTALHIAVESCKPAVVETLLGYGADVHIRGGK 728
A G + ++ LLQ G +V+ + + + +LH A +++ LL GA+ +
Sbjct: 119 AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQDNAEIIKLLLRKGANKECQDDF 178
Query: 729 QRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGG 788
TPL +AA+ + ++ L+ SGA N D TP+ +AA+ G+ + LLL G
Sbjct: 179 GI-TPLFVAAQYGKLESLSI-LISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGA 236
Query: 789 DP 790
DP
Sbjct: 237 DP 238
>AJ315532-1|CAC86666.1| 1210|Homo sapiens NG36/G9a protein.
Length = 1210
Score = 105 bits (251), Expect = 2e-21
Identities = 82/277 (29%), Positives = 133/277 (48%), Gaps = 6/277 (2%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH-NAMI 1022
SA+ L G + AL+ ++ K R L+L+ G V ++ D+ +
Sbjct: 619 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 678
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++
Sbjct: 679 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YM 737
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
Q V + +DG+TC H AA G+++++ L+ + V +A++ TP+ AAE
Sbjct: 738 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQDS-GGWTPIIWAAEH 795
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
H +V+R+L+ GA T + +H A+ G + +V+ + + G TPL
Sbjct: 796 KHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPL 855
Query: 1203 HIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
HIAA + V LS P E T L P
Sbjct: 856 HIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 892
Score = 91.1 bits (216), Expect = 4e-17
Identities = 65/213 (30%), Positives = 108/213 (50%), Gaps = 6/213 (2%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 686 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 744
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
T LH AA G +E+ LLL G +++A D G PI AA++ + EV+++
Sbjct: 745 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 804
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L + ++ + T + N C H A+ GS + E L+ + + A N D TPL +AA
Sbjct: 805 LTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGD-TPLHIAAR 860
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ D V + + GA+ N+ G TA L E
Sbjct: 861 ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 893
Score = 81.4 bits (192), Expect = 3e-14
Identities = 76/249 (30%), Positives = 113/249 (45%), Gaps = 18/249 (7%)
Query: 1101 HIAAIQGSV-KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
+++ QG + KVI LM D ++ + TPL AA+ G ++ VL++AGA+
Sbjct: 655 YLSVKQGELQKVI--LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 712
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
++ T + A + H V M S ++ G T LH AA G E V LLS
Sbjct: 713 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 772
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G V A G TP+ AA + + V+R+LL + G NE
Sbjct: 773 --TGQVDVNAQDS----------GGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEEN 819
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
LH A F G +I +LL+ +L H+ + HG T LHIA+ ++ V + L +GA
Sbjct: 820 IC-LHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 877
Query: 1340 NATDKNGWT 1348
+K G T
Sbjct: 878 ELRNKEGDT 886
Score = 79.4 bits (187), Expect = 1e-13
Identities = 50/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+S TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 683 QSKRTPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQR 740
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLN 1360
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+ AA+ H+
Sbjct: 741 GG-CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIE 799
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
V+++L GA N + +A+ + E LL+ D ++
Sbjct: 800 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 847
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/207 (30%), Positives = 96/207 (46%), Gaps = 15/207 (7%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 687 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 745
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
S+ E G T LH AA GN +V LLL++ V +A + G+ P+ A
Sbjct: 746 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA-QDSGGWTPIIWA 792
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
H+ ++ +LL+R A++ TD LH AS G + EVLL +++A + +G
Sbjct: 793 AEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 851
Query: 1347 WTPLHCAAKAGHLNVVKLLCESGASPK 1373
TPLH AA+ + + V L GA+P+
Sbjct: 852 DTPLHIAARESYHDCVLLFLSRGANPE 878
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL A +G +++ + LL A ++ D + R+ L A + +L+V ++ + S
Sbjct: 687 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 746
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K +G T LH AA G +V L+ ++ TP+ AA IEV ++LL
Sbjct: 747 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 806
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
GA++ TD +H A+ + + ++ L +L A G+T HIAA +
Sbjct: 807 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHD 865
Query: 1111 VIEELMKFDRTGVISARNKLNDS 1133
+ L+ R RNK D+
Sbjct: 866 CV--LLFLSRGANPELRNKEGDT 886
Score = 69.3 bits (162), Expect = 1e-10
Identities = 67/253 (26%), Positives = 117/253 (46%), Gaps = 31/253 (12%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++++ K G L ++L+L D DP ++ D + TPL A + +I L++
Sbjct: 654 LYLSVKQGELQKVILMLLDNLDPNFQS-----DQQSKRTPLHAAAQKGSVEICHVLLQ-- 706
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A I+AVD+ + L A + +V + +++ G V
Sbjct: 707 --------AGANINAVDKQQRTPLMEA---------VVNNHLEVARYMVQRGGCV-YSKE 748
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
+ T H+ A GN ++++ ++ ST V +N Q+S GWTP++ A H++++
Sbjct: 749 EDGSTCLHHAAKIGNLEMVSLLL---STGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRM 803
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY 1007
LLT A V + D E LH A+ G + + LL + +++ +G T LH+AA Y
Sbjct: 804 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 863
Query: 1008 AHLV-KFLIRDHN 1019
V FL R N
Sbjct: 864 HDCVLLFLSRGAN 876
Score = 67.7 bits (158), Expect = 4e-10
Identities = 46/172 (26%), Positives = 84/172 (48%), Gaps = 4/172 (2%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 714 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 771
Query: 119 DYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
G V V+A + G TP+ AA +++ A+ + DNE+ +H A+ G A
Sbjct: 772 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 831
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
AI E+L + + + G T +HIA+ + DC ++ +G + NK
Sbjct: 832 AIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 882
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 792 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 850
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 851 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 909
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 910 GVGNRAIRTEKIICRDVARGYENVPIPC 937
Score = 64.1 bits (149), Expect = 5e-09
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 16/200 (8%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 687 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 733
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
R ++ G + E+G LH A G++ +V LLLS +++ D G T +
Sbjct: 734 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 791
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLN 1379
A+ H H +++ +LL +GA++ TD LH A+ G + ++L + +
Sbjct: 792 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 851
Query: 1380 CAPIWFAASENHND-VLEYL 1398
P+ AA E+++D VL +L
Sbjct: 852 DTPLHIAARESYHDCVLLFL 871
Score = 52.4 bits (120), Expect = 2e-05
Identities = 46/192 (23%), Positives = 81/192 (42%), Gaps = 3/192 (1%)
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGK-TGLHIASTHGHYQMVEVLLGQGAEINA 1341
L+L+ G + V L+L + + +D+ K T LH A+ G ++ VLL GA INA
Sbjct: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
DK TPL A HL V + + + G S+ + AA + +++ LL
Sbjct: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKER 1461
+ D + ++ + H +I + +L A V NI ++ ++
Sbjct: 774 GQVDVNAQDSGG--WTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 831
Query: 1462 AKDLIAAGKQCE 1473
A + +C+
Sbjct: 832 AIAEVLLNARCD 843
Score = 50.0 bits (114), Expect = 9e-05
Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 2/156 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L L+V+ G V +L ++ + T LH AA++ V++ +L+ GA ++A
Sbjct: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED-RTPMHLAAENGHAAIIELLAD 185
+ +TPL A + +Y R + ED T +H AA+ G+ ++ LL
Sbjct: 714 VDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 772
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + + G T + A+ + H + ML +G
Sbjct: 773 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 808
Score = 49.6 bits (113), Expect = 1e-04
Identities = 41/159 (25%), Positives = 68/159 (42%), Gaps = 4/159 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + GN MV LLS + + A G T + AA + +++ R+L+ GA
Sbjct: 751 GSTCLHHAAKIGNLEMVSLLLSTGQVD-VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGA 809
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
V T+ LH A+ G + + R + + TP+H+AA E+ H ++
Sbjct: 810 DVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 869
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L+ + R K+G T + A+ L +K
Sbjct: 870 FLSRGANPEL--RNKEGDTAWDLTPERSDVWFALQLNRK 906
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 689 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 748
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
+ T LH AA+I + + +L+L N G TP+ AA+ ++ + +LL
Sbjct: 749 -EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807
Query: 787 GGD 789
G D
Sbjct: 808 GAD 810
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 687 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 744
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 745 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 774
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 785 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 842
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 843 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 902
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 903 LNRKLRLGVGNR 914
Score = 36.7 bits (81), Expect = 0.89
Identities = 63/272 (23%), Positives = 114/272 (41%), Gaps = 39/272 (14%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLATLVLLLEDGGDPL 791
L+++ + + K LMLL + PN ++ TP+H AA+ G++ +LL+ G +
Sbjct: 654 LYLSVKQGELQKVILMLLDN-LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 712
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
K TPL A + ++ R++++ +G V + +EDG++ L
Sbjct: 713 AVDK-------QQRTPLMEAVVNNHLEVARYMVQ-----RGGCVYSK-----EEDGSTCL 755
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENG-ADVSLQTRHNHETAFHYCAIAGNNDVMTEMI 910
H+A K+ + ++V L+ G DV+ Q T + A + +V+ ++
Sbjct: 756 HHAAKI---------GNLEMVSLLLSTGQVDVNAQDSGGW-TPIIWAAEHKHIEVIRMLL 805
Query: 911 AHISTADVSRALNRQN-SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
ADV+ N +N + W A G + LL + + G + LH+A
Sbjct: 806 TR--GADVTLTDNEENICLHW-----ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 858
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A Y L+ A + + G TA L
Sbjct: 859 ARESYHDCVLLFLSRGANPELRNKEGDTAWDL 890
>AF134726-3|AAD21812.1| 1001|Homo sapiens G9A protein.
Length = 1001
Score = 105 bits (251), Expect = 2e-21
Identities = 82/277 (29%), Positives = 133/277 (48%), Gaps = 6/277 (2%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH-NAMI 1022
SA+ L G + AL+ ++ K R L+L+ G V ++ D+ +
Sbjct: 410 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 469
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++
Sbjct: 470 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YM 528
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
Q V + +DG+TC H AA G+++++ L+ + V +A++ TP+ AAE
Sbjct: 529 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQDS-GGWTPIIWAAEH 586
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
H +V+R+L+ GA T + +H A+ G + +V+ + + G TPL
Sbjct: 587 KHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPL 646
Query: 1203 HIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
HIAA + V LS P E T L P
Sbjct: 647 HIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 683
Score = 91.1 bits (216), Expect = 4e-17
Identities = 65/213 (30%), Positives = 108/213 (50%), Gaps = 6/213 (2%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 477 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 535
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
T LH AA G +E+ LLL G +++A D G PI AA++ + EV+++
Sbjct: 536 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 595
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
L + ++ + T + N C H A+ GS + E L+ + + A N D TPL +AA
Sbjct: 596 LTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGD-TPLHIAAR 651
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ D V + + GA+ N+ G TA L E
Sbjct: 652 ESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 684
Score = 81.4 bits (192), Expect = 3e-14
Identities = 76/249 (30%), Positives = 113/249 (45%), Gaps = 18/249 (7%)
Query: 1101 HIAAIQGSV-KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
+++ QG + KVI LM D ++ + TPL AA+ G ++ VL++AGA+
Sbjct: 446 YLSVKQGELQKVI--LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 503
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
++ T + A + H V M S ++ G T LH AA G E V LLS
Sbjct: 504 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 563
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENG 1279
G V A G TP+ AA + + V+R+LL + G NE
Sbjct: 564 --TGQVDVNAQDS----------GGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEEN 610
Query: 1280 YNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEI 1339
LH A F G +I +LL+ +L H+ + HG T LHIA+ ++ V + L +GA
Sbjct: 611 IC-LHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 668
Query: 1340 NATDKNGWT 1348
+K G T
Sbjct: 669 ELRNKEGDT 677
Score = 79.4 bits (187), Expect = 1e-13
Identities = 50/168 (29%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+S TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 474 QSKRTPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQR 531
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINATDKNGWTPLHCAAKAGHLN 1360
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+ AA+ H+
Sbjct: 532 GG-CVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIE 590
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
V+++L GA N + +A+ + E LL+ D ++
Sbjct: 591 VIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 638
Score = 78.2 bits (184), Expect = 3e-13
Identities = 63/207 (30%), Positives = 96/207 (46%), Gaps = 15/207 (7%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 478 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 536
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
S+ E G T LH AA GN +V LLL++ V +A + G+ P+ A
Sbjct: 537 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA-QDSGGWTPIIWA 583
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
H+ ++ +LL+R A++ TD LH AS G + EVLL +++A + +G
Sbjct: 584 AEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 642
Query: 1347 WTPLHCAAKAGHLNVVKLLCESGASPK 1373
TPLH AA+ + + V L GA+P+
Sbjct: 643 DTPLHIAARESYHDCVLLFLSRGANPE 669
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL A +G +++ + LL A ++ D + R+ L A + +L+V ++ + S
Sbjct: 478 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 537
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K +G T LH AA G +V L+ ++ TP+ AA IEV ++LL
Sbjct: 538 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 597
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
GA++ TD +H A+ + + ++ L +L A G+T HIAA +
Sbjct: 598 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHD 656
Query: 1111 VIEELMKFDRTGVISARNKLNDS 1133
+ L+ R RNK D+
Sbjct: 657 CV--LLFLSRGANPELRNKEGDT 677
Score = 69.3 bits (162), Expect = 1e-10
Identities = 67/253 (26%), Positives = 117/253 (46%), Gaps = 31/253 (12%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++++ K G L ++L+L D DP ++ D + TPL A + +I L++
Sbjct: 445 LYLSVKQGELQKVILMLLDNLDPNFQS-----DQQSKRTPLHAAAQKGSVEICHVLLQ-- 497
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A I+AVD+ + L A + +V + +++ G V
Sbjct: 498 --------AGANINAVDKQQRTPLMEA---------VVNNHLEVARYMVQRGGCV-YSKE 539
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
+ T H+ A GN ++++ ++ ST V +N Q+S GWTP++ A H++++
Sbjct: 540 EDGSTCLHHAAKIGNLEMVSLLL---STGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRM 594
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGY 1007
LLT A V + D E LH A+ G + + LL + +++ +G T LH+AA Y
Sbjct: 595 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 654
Query: 1008 AHLV-KFLIRDHN 1019
V FL R N
Sbjct: 655 HDCVLLFLSRGAN 667
Score = 67.7 bits (158), Expect = 4e-10
Identities = 46/172 (26%), Positives = 84/172 (48%), Gaps = 4/172 (2%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 505 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 562
Query: 119 DYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
G V V+A + G TP+ AA +++ A+ + DNE+ +H A+ G A
Sbjct: 563 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 622
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
AI E+L + + + G T +HIA+ + DC ++ +G + NK
Sbjct: 623 AIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 673
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 583 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 641
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 642 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 700
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 701 GVGNRAIRTEKIICRDVARGYENVPIPC 728
Score = 64.1 bits (149), Expect = 5e-09
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 16/200 (8%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 478 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 524
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
R ++ G + E+G LH A G++ +V LLLS +++ D G T +
Sbjct: 525 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 582
Query: 1320 ASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLN 1379
A+ H H +++ +LL +GA++ TD LH A+ G + ++L + +
Sbjct: 583 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHG 642
Query: 1380 CAPIWFAASENHND-VLEYL 1398
P+ AA E+++D VL +L
Sbjct: 643 DTPLHIAARESYHDCVLLFL 662
Score = 52.4 bits (120), Expect = 2e-05
Identities = 46/192 (23%), Positives = 81/192 (42%), Gaps = 3/192 (1%)
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGK-TGLHIASTHGHYQMVEVLLGQGAEINA 1341
L+L+ G + V L+L + + +D+ K T LH A+ G ++ VLL GA INA
Sbjct: 445 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 504
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
DK TPL A HL V + + + G S+ + AA + +++ LL
Sbjct: 505 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 564
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKER 1461
+ D + ++ + H +I + +L A V NI ++ ++
Sbjct: 565 GQVDVNAQDSGG--WTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 622
Query: 1462 AKDLIAAGKQCE 1473
A + +C+
Sbjct: 623 AIAEVLLNARCD 634
Score = 50.0 bits (114), Expect = 9e-05
Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 2/156 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L L+V+ G V +L ++ + T LH AA++ V++ +L+ GA ++A
Sbjct: 445 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 504
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED-RTPMHLAAENGHAAIIELLAD 185
+ +TPL A + +Y R + ED T +H AA+ G+ ++ LL
Sbjct: 505 VDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 563
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + + G T + A+ + H + ML +G
Sbjct: 564 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 599
Score = 49.6 bits (113), Expect = 1e-04
Identities = 41/159 (25%), Positives = 68/159 (42%), Gaps = 4/159 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + GN MV LLS + + A G T + AA + +++ R+L+ GA
Sbjct: 542 GSTCLHHAAKIGNLEMVSLLLSTGQVD-VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGA 600
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
V T+ LH A+ G + + R + + TP+H+AA E+ H ++
Sbjct: 601 DVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 660
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L+ + R K+G T + A+ L +K
Sbjct: 661 FLSRGANPEL--RNKEGDTAWDLTPERSDVWFALQLNRK 697
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 480 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 539
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
+ T LH AA+I + + +L+L N G TP+ AA+ ++ + +LL
Sbjct: 540 -EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 598
Query: 787 GGD 789
G D
Sbjct: 599 GAD 601
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 478 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 535
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 536 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 565
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 576 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 633
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 634 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 693
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 694 LNRKLRLGVGNR 705
Score = 36.7 bits (81), Expect = 0.89
Identities = 63/272 (23%), Positives = 114/272 (41%), Gaps = 39/272 (14%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLATLVLLLEDGGDPL 791
L+++ + + K LMLL + PN ++ TP+H AA+ G++ +LL+ G +
Sbjct: 445 LYLSVKQGELQKVILMLLDN-LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 503
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
K TPL A + ++ R++++ +G V + +EDG++ L
Sbjct: 504 AVDK-------QQRTPLMEAVVNNHLEVARYMVQ-----RGGCVYSK-----EEDGSTCL 546
Query: 852 HYACKVTKEEVKIPTADRQVVKCLIENG-ADVSLQTRHNHETAFHYCAIAGNNDVMTEMI 910
H+A K+ + ++V L+ G DV+ Q T + A + +V+ ++
Sbjct: 547 HHAAKI---------GNLEMVSLLLSTGQVDVNAQDSGGW-TPIIWAAEHKHIEVIRMLL 596
Query: 911 AHISTADVSRALNRQN-SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
ADV+ N +N + W A G + LL + + G + LH+A
Sbjct: 597 TR--GADVTLTDNEENICLHW-----ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 649
Query: 970 AEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A Y L+ A + + G TA L
Sbjct: 650 ARESYHDCVLLFLSRGANPELRNKEGDTAWDL 681
>BC110915-1|AAI10916.1| 553|Homo sapiens ASB3 protein protein.
Length = 553
Score = 104 bits (250), Expect = 3e-21
Identities = 84/268 (31%), Positives = 125/268 (46%), Gaps = 22/268 (8%)
Query: 1138 LAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM----RSTNTLRIS 1193
LAA G+ V+R L++ G S + G +H AA H L ++ S N +++
Sbjct: 51 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 110
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAY 1253
+ + G LH+AA G + V+ LL P +L TPL LA
Sbjct: 111 TFE-GFCALHLAASQGHWKIVQILLE------AGADPNATTLEET-------TPLFLAVE 156
Query: 1254 NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHG 1313
NG +V+RLLL G + + + G+N LH A F + I+ LLL + A D G
Sbjct: 157 NGQIDVLRLLLQH-GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANK-ECQDDFG 214
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPK 1373
T L +A+ +G + + +L+ GA +N + TPL AA+ GH V+LL SGA P
Sbjct: 215 ITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD 274
Query: 1374 SETNLNC--APIWFAASENHNDVLEYLL 1399
N + PI AA H +L+ L+
Sbjct: 275 LYCNEDSWQLPIHAAAQMGHTKILDLLI 302
Score = 95.1 bits (226), Expect = 2e-18
Identities = 72/239 (30%), Positives = 117/239 (48%), Gaps = 14/239 (5%)
Query: 1167 TAVHLAAEHGHTNVL-DVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTV 1225
+ V LAA G+ VL +++ ++ ++ + G P+H AAY+ E ++ L++
Sbjct: 47 STVGLAAREGNVKVLRKLLKKGRSVDVADNR-GWMPIHEAAYHNSVECLQMLIN------ 99
Query: 1226 KSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHL 1285
A + + + + E G LHLAA G+ +V++LL AG +A + E PL L
Sbjct: 100 ---ADSSENYIKMKTFE-GFCALHLAASQGHWKIVQILLE-AGADPNATTLEET-TPLFL 153
Query: 1286 ACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKN 1345
A G + ++ LLL A + S G LH AS + +++++LL +GA D
Sbjct: 154 AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDF 213
Query: 1346 GWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G TPL AA+ G L + +L SGA+ + P++ AA E H +E LL D
Sbjct: 214 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD 272
Score = 91.5 bits (217), Expect = 3e-17
Identities = 84/315 (26%), Positives = 154/315 (48%), Gaps = 23/315 (7%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA--M 1021
S + LAA G ++V LL ++ G +H AA + ++ LI ++
Sbjct: 47 STVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENY 106
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
I + T + LHLAA+ G ++ ++LLE GA+ +AT P+ A +N +V++L
Sbjct: 107 IKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLL 166
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
LQ N+ + + G H A+ Q + ++I+ L+ R G TPL +AA+
Sbjct: 167 LQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLL---RKGANKECQDDFGITPLFVAAQ 223
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT---LRISSKKLG 1198
G + + +L+ +GA+ + T + +AA+ GHT ++++ S+ L +
Sbjct: 224 YGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQ 283
Query: 1199 LTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNEN 1258
L P+H AA G + + +LL +P T ++ TG++ V +P++ A + G+E+
Sbjct: 284 L-PIHAAAQMGHTK-ILDLL--IPLTNRA-CDTGLNKV---------SPVYSAVFGGHED 329
Query: 1259 VVRLLLNSAGVQADA 1273
+ +LL + G DA
Sbjct: 330 CLEILLRN-GYSPDA 343
Score = 90.6 bits (215), Expect = 5e-17
Identities = 72/271 (26%), Positives = 126/271 (46%), Gaps = 11/271 (4%)
Query: 920 RALNRQNSIGWTPLLIACHRGHMQLVNTLLT-----NHARVDVFDVEGRSALHLAAEHGY 974
R+++ ++ GW P+ A + ++ + L+ N+ ++ F EG ALHLAA G+
Sbjct: 69 RSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTF--EGFCALHLAASQGH 126
Query: 975 LQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMID-VLTLKKQTPL 1033
++ LL A N+ T L LA NG +++ L++ H A ++ ++ L
Sbjct: 127 WKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ-HGANVNGSHSMCGWNSL 185
Query: 1034 HLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT 1093
H A+ E+ KLLL GAN + D+ G P+ AAQ E + + + N V
Sbjct: 186 HQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGAN-VNCQA 244
Query: 1094 KDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR 1153
D T IAA +G K +E L+ + N+ + P+ AA+ GH ++ +L+
Sbjct: 245 LDKATPLFIAAQEGHTKCVELLLSSGADPDLYC-NEDSWQLPIHAAAQMGHTKILDLLIP 303
Query: 1154 AGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
D ++ V+ A GH + L+++
Sbjct: 304 LTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 334
Score = 84.2 bits (199), Expect = 4e-15
Identities = 80/312 (25%), Positives = 142/312 (45%), Gaps = 18/312 (5%)
Query: 1069 AAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
AA+ +V++ L++ ++ +A + G H AA SV+ ++ L+ D +
Sbjct: 52 AAREGNVKVLRKLLKKGRSVDVADNR-GWMPIHEAAYHNSVECLQMLINADSSENYIKMK 110
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTN 1188
L LAA GH +V++L+ AGA T + LA E+G +VL ++
Sbjct: 111 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 170
Query: 1189 T-LRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+ S G LH A++ AE ++ LL G K + G+TP
Sbjct: 171 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK--GANKE-----------CQDDFGITP 217
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL-L 1306
L +AA G + +L++S G + + + PL +A GH V LLLS A+ L
Sbjct: 218 LFVAAQYGKLESLSILISS-GANVNCQALDKA-TPLFIAAQEGHTKCVELLLSSGADPDL 275
Query: 1307 HSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
+ + + +H A+ GH +++++L+ T N +P++ A GH + +++L
Sbjct: 276 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 335
Query: 1367 ESGASPKSETNL 1378
+G SP ++ L
Sbjct: 336 RNGYSPDAQACL 347
Score = 72.5 bits (170), Expect = 1e-11
Identities = 44/133 (33%), Positives = 71/133 (53%), Gaps = 1/133 (0%)
Query: 657 KYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLL 716
K K F+G ++H AA GH I+ LL+ G + TT + T L +AVE+ + V+ LL
Sbjct: 108 KMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL 167
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
+GA+V+ LH A + + +LL+ GA + G+TP+ VAA++G
Sbjct: 168 QHGANVNGSHSMCGWNSLH-QASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGK 226
Query: 777 LATLVLLLEDGGD 789
L +L +L+ G +
Sbjct: 227 LESLSILISSGAN 239
Score = 60.1 bits (139), Expect = 8e-08
Identities = 46/153 (30%), Positives = 73/153 (47%), Gaps = 5/153 (3%)
Query: 647 RMIFWDTFFEKYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVES 706
R++ F E Y D ++ AAR G+V ++ LL+KG SVDV N + +H A
Sbjct: 31 RLVKQMDFTEAYA--DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYH 88
Query: 707 CKPAVVETLLGYGADVHIRGGKQRE--TPLHIAARIPDGDKCALMLLKSGAGPNKATEDG 764
++ L+ + + K E LH+AA K +LL++GA PN T +
Sbjct: 89 NSVECLQMLINADSSENYIKMKTFEGFCALHLAAS-QGHWKIVQILLEAGADPNATTLEE 147
Query: 765 MTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVC 797
TP+ +A + G + L LLL+ G + +C
Sbjct: 148 TTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC 180
Score = 58.4 bits (135), Expect = 3e-07
Identities = 42/124 (33%), Positives = 64/124 (51%), Gaps = 4/124 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G S+H A+ + II LL+KG + + + T L +A + K + L+ GA+V
Sbjct: 181 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 240
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPN-KATEDG-MTPVHVAAKFGNLATL 780
+ + + TPL IAA+ KC +LL SGA P+ ED P+H AA+ G+ L
Sbjct: 241 NCQ-ALDKATPLFIAAQ-EGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKIL 298
Query: 781 VLLL 784
LL+
Sbjct: 299 DLLI 302
Score = 55.6 bits (128), Expect = 2e-06
Identities = 42/146 (28%), Positives = 67/146 (45%), Gaps = 2/146 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LAVE G ++R LL A + + G +LH A+ + + ++ ++L+ GA +
Sbjct: 150 PLFLAVENGQIDVLRLLLQ-HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 208
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ G TPL +AA G + AN + TP+ +AA+ GH +ELL
Sbjct: 209 CQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLS 268
Query: 186 KFKASIFERTKDGSTL-MHIASLNGH 210
+D L +H A+ GH
Sbjct: 269 SGADPDLYCNEDSWQLPIHAAAQMGH 294
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/126 (30%), Positives = 61/126 (48%), Gaps = 3/126 (2%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G T L +AA+ ++ IL+ GA V+ TPL IAA EG V+ A+
Sbjct: 214 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADP 273
Query: 158 AIADNED--RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAM 215
+ NED + P+H AA+ GH I++LL + + + + ++ A GH DC
Sbjct: 274 DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRAC-DTGLNKVSPVYSAVFGGHEDCLE 332
Query: 216 MLFKKG 221
+L + G
Sbjct: 333 ILLRNG 338
Score = 52.0 bits (119), Expect = 2e-05
Identities = 42/181 (23%), Positives = 76/181 (41%), Gaps = 5/181 (2%)
Query: 69 LAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA---VVD 125
LA GN ++R+LL + + G +H AA V+ ++L++ + +
Sbjct: 51 LAAREGNVKVLRKLL--KKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIK 108
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
G LH+AA++G +V+ A+ E+ TP+ LA ENG ++ LL
Sbjct: 109 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 168
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDEVLFVKIE 245
+ G +H AS +A+ +L +KG + + F + K+E
Sbjct: 169 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 228
Query: 246 N 246
+
Sbjct: 229 S 229
Score = 48.4 bits (110), Expect = 3e-04
Identities = 36/122 (29%), Positives = 61/122 (50%), Gaps = 3/122 (2%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTND-NYTALHIAVESCKPAVVETLLGYGADVHIRGGK 728
A G + ++ LLQ G +V+ + + + +LH A +++ LL GA+ +
Sbjct: 154 AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDF 213
Query: 729 QRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGG 788
TPL +AA+ + ++ L+ SGA N D TP+ +AA+ G+ + LLL G
Sbjct: 214 GI-TPLFVAAQYGKLESLSI-LISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGA 271
Query: 789 DP 790
DP
Sbjct: 272 DP 273
>BC009569-1|AAH09569.1| 518|Homo sapiens ankyrin repeat and SOCS
box-containing 3 protein.
Length = 518
Score = 104 bits (250), Expect = 3e-21
Identities = 84/268 (31%), Positives = 125/268 (46%), Gaps = 22/268 (8%)
Query: 1138 LAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM----RSTNTLRIS 1193
LAA G+ V+R L++ G S + G +H AA H L ++ S N +++
Sbjct: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAY 1253
+ + G LH+AA G + V+ LL P +L TPL LA
Sbjct: 76 TFE-GFCALHLAASQGHWKIVQILLE------AGADPNATTLEET-------TPLFLAVE 121
Query: 1254 NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHG 1313
NG +V+RLLL G + + + G+N LH A F + I+ LLL + A D G
Sbjct: 122 NGQIDVLRLLLQH-GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANK-ECQDDFG 179
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPK 1373
T L +A+ +G + + +L+ GA +N + TPL AA+ GH V+LL SGA P
Sbjct: 180 ITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD 239
Query: 1374 SETNLNC--APIWFAASENHNDVLEYLL 1399
N + PI AA H +L+ L+
Sbjct: 240 LYCNEDSWQLPIHAAAQMGHTKILDLLI 267
Score = 95.1 bits (226), Expect = 2e-18
Identities = 72/239 (30%), Positives = 117/239 (48%), Gaps = 14/239 (5%)
Query: 1167 TAVHLAAEHGHTNVL-DVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTV 1225
+ V LAA G+ VL +++ ++ ++ + G P+H AAY+ E ++ L++
Sbjct: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNR-GWMPIHEAAYHNSVECLQMLIN------ 64
Query: 1226 KSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHL 1285
A + + + + E G LHLAA G+ +V++LL AG +A + E PL L
Sbjct: 65 ---ADSSENYIKMKTFE-GFCALHLAASQGHWKIVQILLE-AGADPNATTLEET-TPLFL 118
Query: 1286 ACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKN 1345
A G + ++ LLL A + S G LH AS + +++++LL +GA D
Sbjct: 119 AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDF 178
Query: 1346 GWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G TPL AA+ G L + +L SGA+ + P++ AA E H +E LL D
Sbjct: 179 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD 237
Score = 91.5 bits (217), Expect = 3e-17
Identities = 84/315 (26%), Positives = 154/315 (48%), Gaps = 23/315 (7%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA--M 1021
S + LAA G ++V LL ++ G +H AA + ++ LI ++
Sbjct: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENY 71
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
I + T + LHLAA+ G ++ ++LLE GA+ +AT P+ A +N +V++L
Sbjct: 72 IKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLL 131
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
LQ N+ + + G H A+ Q + ++I+ L+ R G TPL +AA+
Sbjct: 132 LQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLL---RKGANKECQDDFGITPLFVAAQ 188
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT---LRISSKKLG 1198
G + + +L+ +GA+ + T + +AA+ GHT ++++ S+ L +
Sbjct: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQ 248
Query: 1199 LTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNEN 1258
L P+H AA G + + +LL +P T ++ TG++ V +P++ A + G+E+
Sbjct: 249 L-PIHAAAQMGHTK-ILDLL--IPLTNRA-CDTGLNKV---------SPVYSAVFGGHED 294
Query: 1259 VVRLLLNSAGVQADA 1273
+ +LL + G DA
Sbjct: 295 CLEILLRN-GYSPDA 308
Score = 90.6 bits (215), Expect = 5e-17
Identities = 72/271 (26%), Positives = 126/271 (46%), Gaps = 11/271 (4%)
Query: 920 RALNRQNSIGWTPLLIACHRGHMQLVNTLLT-----NHARVDVFDVEGRSALHLAAEHGY 974
R+++ ++ GW P+ A + ++ + L+ N+ ++ F EG ALHLAA G+
Sbjct: 34 RSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTF--EGFCALHLAASQGH 91
Query: 975 LQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMID-VLTLKKQTPL 1033
++ LL A N+ T L LA NG +++ L++ H A ++ ++ L
Sbjct: 92 WKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ-HGANVNGSHSMCGWNSL 150
Query: 1034 HLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT 1093
H A+ E+ KLLL GAN + D+ G P+ AAQ E + + + N V
Sbjct: 151 HQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGAN-VNCQA 209
Query: 1094 KDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR 1153
D T IAA +G K +E L+ + N+ + P+ AA+ GH ++ +L+
Sbjct: 210 LDKATPLFIAAQEGHTKCVELLLSSGADPDLYC-NEDSWQLPIHAAAQMGHTKILDLLIP 268
Query: 1154 AGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
D ++ V+ A GH + L+++
Sbjct: 269 LTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 299
Score = 84.2 bits (199), Expect = 4e-15
Identities = 80/312 (25%), Positives = 142/312 (45%), Gaps = 18/312 (5%)
Query: 1069 AAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
AA+ +V++ L++ ++ +A + G H AA SV+ ++ L+ D +
Sbjct: 17 AAREGNVKVLRKLLKKGRSVDVADNR-GWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTN 1188
L LAA GH +V++L+ AGA T + LA E+G +VL ++
Sbjct: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
Query: 1189 T-LRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+ S G LH A++ AE ++ LL G K + G+TP
Sbjct: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK--GANKE-----------CQDDFGITP 182
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL-L 1306
L +AA G + +L++S G + + + PL +A GH V LLLS A+ L
Sbjct: 183 LFVAAQYGKLESLSILISS-GANVNCQALDKA-TPLFIAAQEGHTKCVELLLSSGADPDL 240
Query: 1307 HSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
+ + + +H A+ GH +++++L+ T N +P++ A GH + +++L
Sbjct: 241 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 300
Query: 1367 ESGASPKSETNL 1378
+G SP ++ L
Sbjct: 301 RNGYSPDAQACL 312
Score = 72.5 bits (170), Expect = 1e-11
Identities = 44/133 (33%), Positives = 71/133 (53%), Gaps = 1/133 (0%)
Query: 657 KYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLL 716
K K F+G ++H AA GH I+ LL+ G + TT + T L +AVE+ + V+ LL
Sbjct: 73 KMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL 132
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
+GA+V+ LH A + + +LL+ GA + G+TP+ VAA++G
Sbjct: 133 QHGANVNGSHSMCGWNSLH-QASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGK 191
Query: 777 LATLVLLLEDGGD 789
L +L +L+ G +
Sbjct: 192 LESLSILISSGAN 204
Score = 59.7 bits (138), Expect = 1e-07
Identities = 45/146 (30%), Positives = 70/146 (47%), Gaps = 5/146 (3%)
Query: 654 FFEKYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVE 713
F E Y D ++ AAR G+V ++ LL+KG SVDV N + +H A ++
Sbjct: 3 FTEAYA--DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQ 60
Query: 714 TLLGYGADVHIRGGKQRE--TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVA 771
L+ + + K E LH+AA K +LL++GA PN T + TP+ +A
Sbjct: 61 MLINADSSENYIKMKTFEGFCALHLAAS-QGHWKIVQILLEAGADPNATTLEETTPLFLA 119
Query: 772 AKFGNLATLVLLLEDGGDPLRKTKVC 797
+ G + L LLL+ G + +C
Sbjct: 120 VENGQIDVLRLLLQHGANVNGSHSMC 145
Score = 58.4 bits (135), Expect = 3e-07
Identities = 42/124 (33%), Positives = 64/124 (51%), Gaps = 4/124 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G S+H A+ + II LL+KG + + + T L +A + K + L+ GA+V
Sbjct: 146 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 205
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPN-KATEDG-MTPVHVAAKFGNLATL 780
+ + + TPL IAA+ KC +LL SGA P+ ED P+H AA+ G+ L
Sbjct: 206 NCQ-ALDKATPLFIAAQ-EGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKIL 263
Query: 781 VLLL 784
LL+
Sbjct: 264 DLLI 267
Score = 55.6 bits (128), Expect = 2e-06
Identities = 42/146 (28%), Positives = 67/146 (45%), Gaps = 2/146 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LAVE G ++R LL A + + G +LH A+ + + ++ ++L+ GA +
Sbjct: 115 PLFLAVENGQIDVLRLLLQ-HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 173
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ G TPL +AA G + AN + TP+ +AA+ GH +ELL
Sbjct: 174 CQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLS 233
Query: 186 KFKASIFERTKDGSTL-MHIASLNGH 210
+D L +H A+ GH
Sbjct: 234 SGADPDLYCNEDSWQLPIHAAAQMGH 259
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/126 (30%), Positives = 61/126 (48%), Gaps = 3/126 (2%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G T L +AA+ ++ IL+ GA V+ TPL IAA EG V+ A+
Sbjct: 179 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADP 238
Query: 158 AIADNED--RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAM 215
+ NED + P+H AA+ GH I++LL + + + + ++ A GH DC
Sbjct: 239 DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRAC-DTGLNKVSPVYSAVFGGHEDCLE 297
Query: 216 MLFKKG 221
+L + G
Sbjct: 298 ILLRNG 303
Score = 52.0 bits (119), Expect = 2e-05
Identities = 42/181 (23%), Positives = 76/181 (41%), Gaps = 5/181 (2%)
Query: 69 LAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA---VVD 125
LA GN ++R+LL + + G +H AA V+ ++L++ + +
Sbjct: 16 LAAREGNVKVLRKLL--KKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIK 73
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
G LH+AA++G +V+ A+ E+ TP+ LA ENG ++ LL
Sbjct: 74 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 133
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDEVLFVKIE 245
+ G +H AS +A+ +L +KG + + F + K+E
Sbjct: 134 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 193
Query: 246 N 246
+
Sbjct: 194 S 194
Score = 48.4 bits (110), Expect = 3e-04
Identities = 36/122 (29%), Positives = 61/122 (50%), Gaps = 3/122 (2%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTND-NYTALHIAVESCKPAVVETLLGYGADVHIRGGK 728
A G + ++ LLQ G +V+ + + + +LH A +++ LL GA+ +
Sbjct: 119 AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDF 178
Query: 729 QRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGG 788
TPL +AA+ + ++ L+ SGA N D TP+ +AA+ G+ + LLL G
Sbjct: 179 GI-TPLFVAAQYGKLESLSI-LISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGA 236
Query: 789 DP 790
DP
Sbjct: 237 DP 238
>BC006488-1|AAH06488.1| 518|Homo sapiens ankyrin repeat and SOCS
box-containing 3 protein.
Length = 518
Score = 104 bits (250), Expect = 3e-21
Identities = 84/268 (31%), Positives = 125/268 (46%), Gaps = 22/268 (8%)
Query: 1138 LAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM----RSTNTLRIS 1193
LAA G+ V+R L++ G S + G +H AA H L ++ S N +++
Sbjct: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAY 1253
+ + G LH+AA G + V+ LL P +L TPL LA
Sbjct: 76 TFE-GFCALHLAASQGHWKIVQILLE------AGADPNATTLEET-------TPLFLAVE 121
Query: 1254 NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHG 1313
NG +V+RLLL G + + + G+N LH A F + I+ LLL + A D G
Sbjct: 122 NGQIDVLRLLLQH-GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANK-ECQDDFG 179
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPK 1373
T L +A+ +G + + +L+ GA +N + TPL AA+ GH V+LL SGA P
Sbjct: 180 ITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD 239
Query: 1374 SETNLNC--APIWFAASENHNDVLEYLL 1399
N + PI AA H +L+ L+
Sbjct: 240 LYCNEDSWQLPIHAAAQMGHTKILDLLI 267
Score = 95.1 bits (226), Expect = 2e-18
Identities = 72/239 (30%), Positives = 117/239 (48%), Gaps = 14/239 (5%)
Query: 1167 TAVHLAAEHGHTNVL-DVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTV 1225
+ V LAA G+ VL +++ ++ ++ + G P+H AAY+ E ++ L++
Sbjct: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNR-GWMPIHEAAYHNSVECLQMLIN------ 64
Query: 1226 KSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHL 1285
A + + + + E G LHLAA G+ +V++LL AG +A + E PL L
Sbjct: 65 ---ADSSENYIKMKTFE-GFCALHLAASQGHWKIVQILLE-AGADPNATTLEET-TPLFL 118
Query: 1286 ACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKN 1345
A G + ++ LLL A + S G LH AS + +++++LL +GA D
Sbjct: 119 AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDF 178
Query: 1346 GWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G TPL AA+ G L + +L SGA+ + P++ AA E H +E LL D
Sbjct: 179 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD 237
Score = 91.5 bits (217), Expect = 3e-17
Identities = 84/315 (26%), Positives = 154/315 (48%), Gaps = 23/315 (7%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA--M 1021
S + LAA G ++V LL ++ G +H AA + ++ LI ++
Sbjct: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENY 71
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
I + T + LHLAA+ G ++ ++LLE GA+ +AT P+ A +N +V++L
Sbjct: 72 IKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLL 131
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
LQ N+ + + G H A+ Q + ++I+ L+ R G TPL +AA+
Sbjct: 132 LQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLL---RKGANKECQDDFGITPLFVAAQ 188
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT---LRISSKKLG 1198
G + + +L+ +GA+ + T + +AA+ GHT ++++ S+ L +
Sbjct: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQ 248
Query: 1199 LTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNEN 1258
L P+H AA G + + +LL +P T ++ TG++ V +P++ A + G+E+
Sbjct: 249 L-PIHAAAQMGHTK-ILDLL--IPLTNRA-CDTGLNKV---------SPVYSAVFGGHED 294
Query: 1259 VVRLLLNSAGVQADA 1273
+ +LL + G DA
Sbjct: 295 CLEILLRN-GYSPDA 308
Score = 90.6 bits (215), Expect = 5e-17
Identities = 72/271 (26%), Positives = 126/271 (46%), Gaps = 11/271 (4%)
Query: 920 RALNRQNSIGWTPLLIACHRGHMQLVNTLLT-----NHARVDVFDVEGRSALHLAAEHGY 974
R+++ ++ GW P+ A + ++ + L+ N+ ++ F EG ALHLAA G+
Sbjct: 34 RSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTF--EGFCALHLAASQGH 91
Query: 975 LQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMID-VLTLKKQTPL 1033
++ LL A N+ T L LA NG +++ L++ H A ++ ++ L
Sbjct: 92 WKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ-HGANVNGSHSMCGWNSL 150
Query: 1034 HLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT 1093
H A+ E+ KLLL GAN + D+ G P+ AAQ E + + + N V
Sbjct: 151 HQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGAN-VNCQA 209
Query: 1094 KDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR 1153
D T IAA +G K +E L+ + N+ + P+ AA+ GH ++ +L+
Sbjct: 210 LDKATPLFIAAQEGHTKCVELLLSSGADPDLYC-NEDSWQLPIHAAAQMGHTKILDLLIP 268
Query: 1154 AGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
D ++ V+ A GH + L+++
Sbjct: 269 LTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 299
Score = 84.2 bits (199), Expect = 4e-15
Identities = 80/312 (25%), Positives = 142/312 (45%), Gaps = 18/312 (5%)
Query: 1069 AAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
AA+ +V++ L++ ++ +A + G H AA SV+ ++ L+ D +
Sbjct: 17 AAREGNVKVLRKLLKKGRSVDVADNR-GWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTN 1188
L LAA GH +V++L+ AGA T + LA E+G +VL ++
Sbjct: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
Query: 1189 T-LRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+ S G LH A++ AE ++ LL G K + G+TP
Sbjct: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK--GANKE-----------CQDDFGITP 182
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL-L 1306
L +AA G + +L++S G + + + PL +A GH V LLLS A+ L
Sbjct: 183 LFVAAQYGKLESLSILISS-GANVNCQALDKA-TPLFIAAQEGHTKCVELLLSSGADPDL 240
Query: 1307 HSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
+ + + +H A+ GH +++++L+ T N +P++ A GH + +++L
Sbjct: 241 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 300
Query: 1367 ESGASPKSETNL 1378
+G SP ++ L
Sbjct: 301 RNGYSPDAQACL 312
Score = 72.5 bits (170), Expect = 1e-11
Identities = 44/133 (33%), Positives = 71/133 (53%), Gaps = 1/133 (0%)
Query: 657 KYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLL 716
K K F+G ++H AA GH I+ LL+ G + TT + T L +AVE+ + V+ LL
Sbjct: 73 KMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL 132
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
+GA+V+ LH A + + +LL+ GA + G+TP+ VAA++G
Sbjct: 133 QHGANVNGSHSMCGWNSLH-QASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGK 191
Query: 777 LATLVLLLEDGGD 789
L +L +L+ G +
Sbjct: 192 LESLSILISSGAN 204
Score = 59.7 bits (138), Expect = 1e-07
Identities = 45/146 (30%), Positives = 70/146 (47%), Gaps = 5/146 (3%)
Query: 654 FFEKYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVE 713
F E Y D ++ AAR G+V ++ LL+KG SVDV N + +H A ++
Sbjct: 3 FTEAYA--DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQ 60
Query: 714 TLLGYGADVHIRGGKQRE--TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVA 771
L+ + + K E LH+AA K +LL++GA PN T + TP+ +A
Sbjct: 61 MLINADSSENYIKMKTFEGFCALHLAAS-QGHWKIVQILLEAGADPNATTLEETTPLFLA 119
Query: 772 AKFGNLATLVLLLEDGGDPLRKTKVC 797
+ G + L LLL+ G + +C
Sbjct: 120 VENGQIDVLRLLLQHGANVNGSHSMC 145
Score = 58.4 bits (135), Expect = 3e-07
Identities = 42/124 (33%), Positives = 64/124 (51%), Gaps = 4/124 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G S+H A+ + II LL+KG + + + T L +A + K + L+ GA+V
Sbjct: 146 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 205
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPN-KATEDG-MTPVHVAAKFGNLATL 780
+ + + TPL IAA+ KC +LL SGA P+ ED P+H AA+ G+ L
Sbjct: 206 NCQ-ALDKATPLFIAAQ-EGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKIL 263
Query: 781 VLLL 784
LL+
Sbjct: 264 DLLI 267
Score = 55.6 bits (128), Expect = 2e-06
Identities = 42/146 (28%), Positives = 67/146 (45%), Gaps = 2/146 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LAVE G ++R LL A + + G +LH A+ + + ++ ++L+ GA +
Sbjct: 115 PLFLAVENGQIDVLRLLLQ-HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 173
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ G TPL +AA G + AN + TP+ +AA+ GH +ELL
Sbjct: 174 CQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLS 233
Query: 186 KFKASIFERTKDGSTL-MHIASLNGH 210
+D L +H A+ GH
Sbjct: 234 SGADPDLYCNEDSWQLPIHAAAQMGH 259
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/126 (30%), Positives = 61/126 (48%), Gaps = 3/126 (2%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G T L +AA+ ++ IL+ GA V+ TPL IAA EG V+ A+
Sbjct: 179 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADP 238
Query: 158 AIADNED--RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAM 215
+ NED + P+H AA+ GH I++LL + + + + ++ A GH DC
Sbjct: 239 DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRAC-DTGLNKVSPVYSAVFGGHEDCLE 297
Query: 216 MLFKKG 221
+L + G
Sbjct: 298 ILLRNG 303
Score = 52.0 bits (119), Expect = 2e-05
Identities = 42/181 (23%), Positives = 76/181 (41%), Gaps = 5/181 (2%)
Query: 69 LAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA---VVD 125
LA GN ++R+LL + + G +H AA V+ ++L++ + +
Sbjct: 16 LAAREGNVKVLRKLL--KKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIK 73
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
G LH+AA++G +V+ A+ E+ TP+ LA ENG ++ LL
Sbjct: 74 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 133
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDEVLFVKIE 245
+ G +H AS +A+ +L +KG + + F + K+E
Sbjct: 134 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 193
Query: 246 N 246
+
Sbjct: 194 S 194
Score = 48.4 bits (110), Expect = 3e-04
Identities = 36/122 (29%), Positives = 61/122 (50%), Gaps = 3/122 (2%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTND-NYTALHIAVESCKPAVVETLLGYGADVHIRGGK 728
A G + ++ LLQ G +V+ + + + +LH A +++ LL GA+ +
Sbjct: 119 AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDF 178
Query: 729 QRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGG 788
TPL +AA+ + ++ L+ SGA N D TP+ +AA+ G+ + LLL G
Sbjct: 179 GI-TPLFVAAQYGKLESLSI-LISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGA 236
Query: 789 DP 790
DP
Sbjct: 237 DP 238
>AK000985-1|BAA91455.1| 518|Homo sapiens protein ( Homo sapiens cDNA
FLJ10123 fis, clone HEMBA1002939, weakly similar to
ANKYRIN R. ).
Length = 518
Score = 104 bits (250), Expect = 3e-21
Identities = 84/268 (31%), Positives = 125/268 (46%), Gaps = 22/268 (8%)
Query: 1138 LAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM----RSTNTLRIS 1193
LAA G+ V+R L++ G S + G +H AA H L ++ S N +++
Sbjct: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAY 1253
+ + G LH+AA G + V+ LL P +L TPL LA
Sbjct: 76 TFE-GFCALHLAASQGHWKIVQILLE------AGADPNATTLEET-------TPLFLAVE 121
Query: 1254 NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHG 1313
NG +V+RLLL G + + + G+N LH A F + I+ LLL + A D G
Sbjct: 122 NGQIDVLRLLLQH-GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANK-ECQDDFG 179
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPK 1373
T L +A+ +G + + +L+ GA +N + TPL AA+ GH V+LL SGA P
Sbjct: 180 ITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD 239
Query: 1374 SETNLNC--APIWFAASENHNDVLEYLL 1399
N + PI AA H +L+ L+
Sbjct: 240 LYCNEDSWQLPIHAAAQMGHTKILDLLI 267
Score = 95.1 bits (226), Expect = 2e-18
Identities = 72/239 (30%), Positives = 117/239 (48%), Gaps = 14/239 (5%)
Query: 1167 TAVHLAAEHGHTNVL-DVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTV 1225
+ V LAA G+ VL +++ ++ ++ + G P+H AAY+ E ++ L++
Sbjct: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNR-GWMPIHEAAYHNSVECLQMLIN------ 64
Query: 1226 KSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHL 1285
A + + + + E G LHLAA G+ +V++LL AG +A + E PL L
Sbjct: 65 ---ADSSENYIKMKTFE-GFCALHLAASQGHWKIVQILLE-AGADPNATTLEET-TPLFL 118
Query: 1286 ACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKN 1345
A G + ++ LLL A + S G LH AS + +++++LL +GA D
Sbjct: 119 AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDF 178
Query: 1346 GWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G TPL AA+ G L + +L SGA+ + P++ AA E H +E LL D
Sbjct: 179 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD 237
Score = 91.5 bits (217), Expect = 3e-17
Identities = 84/315 (26%), Positives = 154/315 (48%), Gaps = 23/315 (7%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA--M 1021
S + LAA G ++V LL ++ G +H AA + ++ LI ++
Sbjct: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENY 71
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
I + T + LHLAA+ G ++ ++LLE GA+ +AT P+ A +N +V++L
Sbjct: 72 IKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLL 131
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
LQ N+ + + G H A+ Q + ++I+ L+ R G TPL +AA+
Sbjct: 132 LQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLL---RKGANKECQDDFGITPLFVAAQ 188
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT---LRISSKKLG 1198
G + + +L+ +GA+ + T + +AA+ GHT ++++ S+ L +
Sbjct: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQ 248
Query: 1199 LTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNEN 1258
L P+H AA G + + +LL +P T ++ TG++ V +P++ A + G+E+
Sbjct: 249 L-PIHAAAQMGHTK-ILDLL--IPLTNRA-CDTGLNKV---------SPVYSAVFGGHED 294
Query: 1259 VVRLLLNSAGVQADA 1273
+ +LL + G DA
Sbjct: 295 CLEILLRN-GYSPDA 308
Score = 90.6 bits (215), Expect = 5e-17
Identities = 72/271 (26%), Positives = 126/271 (46%), Gaps = 11/271 (4%)
Query: 920 RALNRQNSIGWTPLLIACHRGHMQLVNTLLT-----NHARVDVFDVEGRSALHLAAEHGY 974
R+++ ++ GW P+ A + ++ + L+ N+ ++ F EG ALHLAA G+
Sbjct: 34 RSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTF--EGFCALHLAASQGH 91
Query: 975 LQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMID-VLTLKKQTPL 1033
++ LL A N+ T L LA NG +++ L++ H A ++ ++ L
Sbjct: 92 WKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ-HGANVNGSHSMCGWNSL 150
Query: 1034 HLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT 1093
H A+ E+ KLLL GAN + D+ G P+ AAQ E + + + N V
Sbjct: 151 HQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGAN-VNCQA 209
Query: 1094 KDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR 1153
D T IAA +G K +E L+ + N+ + P+ AA+ GH ++ +L+
Sbjct: 210 LDKATPLFIAAQEGHTKCVELLLSSGADPDLYC-NEDSWQLPIHAAAQMGHTKILDLLIP 268
Query: 1154 AGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
D ++ V+ A GH + L+++
Sbjct: 269 LTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 299
Score = 84.2 bits (199), Expect = 4e-15
Identities = 80/312 (25%), Positives = 142/312 (45%), Gaps = 18/312 (5%)
Query: 1069 AAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
AA+ +V++ L++ ++ +A + G H AA SV+ ++ L+ D +
Sbjct: 17 AAREGNVKVLRKLLKKGRSVDVADNR-GWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTN 1188
L LAA GH +V++L+ AGA T + LA E+G +VL ++
Sbjct: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
Query: 1189 T-LRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+ S G LH A++ AE ++ LL G K + G+TP
Sbjct: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK--GANKE-----------CQDDFGITP 182
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL-L 1306
L +AA G + +L++S G + + + PL +A GH V LLLS A+ L
Sbjct: 183 LFVAAQYGKLESLSILISS-GANVNCQALDKA-TPLFIAAQEGHTKCVELLLSSGADPDL 240
Query: 1307 HSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
+ + + +H A+ GH +++++L+ T N +P++ A GH + +++L
Sbjct: 241 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 300
Query: 1367 ESGASPKSETNL 1378
+G SP ++ L
Sbjct: 301 RNGYSPDAQACL 312
Score = 72.5 bits (170), Expect = 1e-11
Identities = 44/133 (33%), Positives = 71/133 (53%), Gaps = 1/133 (0%)
Query: 657 KYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLL 716
K K F+G ++H AA GH I+ LL+ G + TT + T L +AVE+ + V+ LL
Sbjct: 73 KMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL 132
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
+GA+V+ LH A + + +LL+ GA + G+TP+ VAA++G
Sbjct: 133 QHGANVNGSHSMCGWNSLH-QASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGK 191
Query: 777 LATLVLLLEDGGD 789
L +L +L+ G +
Sbjct: 192 LESLSILISSGAN 204
Score = 59.7 bits (138), Expect = 1e-07
Identities = 45/146 (30%), Positives = 70/146 (47%), Gaps = 5/146 (3%)
Query: 654 FFEKYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVE 713
F E Y D ++ AAR G+V ++ LL+KG SVDV N + +H A ++
Sbjct: 3 FTEAYA--DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQ 60
Query: 714 TLLGYGADVHIRGGKQRE--TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVA 771
L+ + + K E LH+AA K +LL++GA PN T + TP+ +A
Sbjct: 61 MLINADSSENYIKMKTFEGFCALHLAAS-QGHWKIVQILLEAGADPNATTLEETTPLFLA 119
Query: 772 AKFGNLATLVLLLEDGGDPLRKTKVC 797
+ G + L LLL+ G + +C
Sbjct: 120 VENGQIDVLRLLLQHGANVNGSHSMC 145
Score = 58.4 bits (135), Expect = 3e-07
Identities = 42/124 (33%), Positives = 64/124 (51%), Gaps = 4/124 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G S+H A+ + II LL+KG + + + T L +A + K + L+ GA+V
Sbjct: 146 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 205
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPN-KATEDG-MTPVHVAAKFGNLATL 780
+ + + TPL IAA+ KC +LL SGA P+ ED P+H AA+ G+ L
Sbjct: 206 NCQ-ALDKATPLFIAAQ-EGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKIL 263
Query: 781 VLLL 784
LL+
Sbjct: 264 DLLI 267
Score = 55.6 bits (128), Expect = 2e-06
Identities = 42/146 (28%), Positives = 67/146 (45%), Gaps = 2/146 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LAVE G ++R LL A + + G +LH A+ + + ++ ++L+ GA +
Sbjct: 115 PLFLAVENGQIDVLRLLLQ-HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 173
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ G TPL +AA G + AN + TP+ +AA+ GH +ELL
Sbjct: 174 CQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLS 233
Query: 186 KFKASIFERTKDGSTL-MHIASLNGH 210
+D L +H A+ GH
Sbjct: 234 SGADPDLYCNEDSWQLPIHAAAQMGH 259
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/126 (30%), Positives = 61/126 (48%), Gaps = 3/126 (2%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G T L +AA+ ++ IL+ GA V+ TPL IAA EG V+ A+
Sbjct: 179 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADP 238
Query: 158 AIADNED--RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAM 215
+ NED + P+H AA+ GH I++LL + + + + ++ A GH DC
Sbjct: 239 DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRAC-DTGLNKVSPVYSAVFGGHEDCLE 297
Query: 216 MLFKKG 221
+L + G
Sbjct: 298 ILLRNG 303
Score = 52.0 bits (119), Expect = 2e-05
Identities = 42/181 (23%), Positives = 76/181 (41%), Gaps = 5/181 (2%)
Query: 69 LAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA---VVD 125
LA GN ++R+LL + + G +H AA V+ ++L++ + +
Sbjct: 16 LAAREGNVKVLRKLL--KKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIK 73
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
G LH+AA++G +V+ A+ E+ TP+ LA ENG ++ LL
Sbjct: 74 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 133
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDEVLFVKIE 245
+ G +H AS +A+ +L +KG + + F + K+E
Sbjct: 134 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 193
Query: 246 N 246
+
Sbjct: 194 S 194
Score = 48.4 bits (110), Expect = 3e-04
Identities = 36/122 (29%), Positives = 61/122 (50%), Gaps = 3/122 (2%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTND-NYTALHIAVESCKPAVVETLLGYGADVHIRGGK 728
A G + ++ LLQ G +V+ + + + +LH A +++ LL GA+ +
Sbjct: 119 AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDF 178
Query: 729 QRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGG 788
TPL +AA+ + ++ L+ SGA N D TP+ +AA+ G+ + LLL G
Sbjct: 179 GI-TPLFVAAQYGKLESLSI-LISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGA 236
Query: 789 DP 790
DP
Sbjct: 237 DP 238
>AF156778-1|AAD41895.1| 518|Homo sapiens ASB-3 protein protein.
Length = 518
Score = 104 bits (250), Expect = 3e-21
Identities = 84/268 (31%), Positives = 125/268 (46%), Gaps = 22/268 (8%)
Query: 1138 LAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM----RSTNTLRIS 1193
LAA G+ V+R L++ G S + G +H AA H L ++ S N +++
Sbjct: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAY 1253
+ + G LH+AA G + V+ LL P +L TPL LA
Sbjct: 76 TFE-GFCALHLAASQGHWKIVQILLE------AGADPNATTLEET-------TPLFLAVE 121
Query: 1254 NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHG 1313
NG +V+RLLL G + + + G+N LH A F + I+ LLL + A D G
Sbjct: 122 NGQIDVLRLLLQH-GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANK-ECQDDFG 179
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPK 1373
T L +A+ +G + + +L+ GA +N + TPL AA+ GH V+LL SGA P
Sbjct: 180 ITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD 239
Query: 1374 SETNLNC--APIWFAASENHNDVLEYLL 1399
N + PI AA H +L+ L+
Sbjct: 240 LYCNEDSWQLPIHAAAQMGHTKILDLLI 267
Score = 95.1 bits (226), Expect = 2e-18
Identities = 72/239 (30%), Positives = 117/239 (48%), Gaps = 14/239 (5%)
Query: 1167 TAVHLAAEHGHTNVL-DVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTV 1225
+ V LAA G+ VL +++ ++ ++ + G P+H AAY+ E ++ L++
Sbjct: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNR-GWMPIHEAAYHNSVECLQMLIN------ 64
Query: 1226 KSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHL 1285
A + + + + E G LHLAA G+ +V++LL AG +A + E PL L
Sbjct: 65 ---ADSSENYIKMKTFE-GFCALHLAASQGHWKIVQILLE-AGADPNATTLEET-TPLFL 118
Query: 1286 ACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKN 1345
A G + ++ LLL A + S G LH AS + +++++LL +GA D
Sbjct: 119 AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDF 178
Query: 1346 GWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G TPL AA+ G L + +L SGA+ + P++ AA E H +E LL D
Sbjct: 179 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD 237
Score = 91.5 bits (217), Expect = 3e-17
Identities = 84/315 (26%), Positives = 154/315 (48%), Gaps = 23/315 (7%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA--M 1021
S + LAA G ++V LL ++ G +H AA + ++ LI ++
Sbjct: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENY 71
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
I + T + LHLAA+ G ++ ++LLE GA+ +AT P+ A +N +V++L
Sbjct: 72 IKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLL 131
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
LQ N+ + + G H A+ Q + ++I+ L+ R G TPL +AA+
Sbjct: 132 LQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLL---RKGANKECQDDFGITPLFVAAQ 188
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT---LRISSKKLG 1198
G + + +L+ +GA+ + T + +AA+ GHT ++++ S+ L +
Sbjct: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQ 248
Query: 1199 LTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNEN 1258
L P+H AA G + + +LL +P T ++ TG++ V +P++ A + G+E+
Sbjct: 249 L-PIHAAAQMGHTK-ILDLL--IPLTNRA-CDTGLNKV---------SPVYSAVFGGHED 294
Query: 1259 VVRLLLNSAGVQADA 1273
+ +LL + G DA
Sbjct: 295 CLEILLRN-GYSPDA 308
Score = 90.6 bits (215), Expect = 5e-17
Identities = 72/271 (26%), Positives = 126/271 (46%), Gaps = 11/271 (4%)
Query: 920 RALNRQNSIGWTPLLIACHRGHMQLVNTLLT-----NHARVDVFDVEGRSALHLAAEHGY 974
R+++ ++ GW P+ A + ++ + L+ N+ ++ F EG ALHLAA G+
Sbjct: 34 RSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTF--EGFCALHLAASQGH 91
Query: 975 LQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMID-VLTLKKQTPL 1033
++ LL A N+ T L LA NG +++ L++ H A ++ ++ L
Sbjct: 92 WKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ-HGANVNGSHSMCGWNSL 150
Query: 1034 HLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT 1093
H A+ E+ KLLL GAN + D+ G P+ AAQ E + + + N V
Sbjct: 151 HQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGAN-VNCQA 209
Query: 1094 KDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR 1153
D T IAA +G K +E L+ + N+ + P+ AA+ GH ++ +L+
Sbjct: 210 LDKATPLFIAAQEGHTKCVELLLSSGADPDLYC-NEDSWQLPIHAAAQMGHTKILDLLIP 268
Query: 1154 AGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
D ++ V+ A GH + L+++
Sbjct: 269 LTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 299
Score = 84.2 bits (199), Expect = 4e-15
Identities = 80/312 (25%), Positives = 142/312 (45%), Gaps = 18/312 (5%)
Query: 1069 AAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
AA+ +V++ L++ ++ +A + G H AA SV+ ++ L+ D +
Sbjct: 17 AAREGNVKVLRKLLKKGRSVDVADNR-GWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTN 1188
L LAA GH +V++L+ AGA T + LA E+G +VL ++
Sbjct: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
Query: 1189 T-LRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+ S G LH A++ AE ++ LL G K + G+TP
Sbjct: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK--GANKE-----------CQDDFGITP 182
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL-L 1306
L +AA G + +L++S G + + + PL +A GH V LLLS A+ L
Sbjct: 183 LFVAAQYGKLESLSILISS-GANVNCQALDKA-TPLFIAAQEGHTKCVELLLSSGADPDL 240
Query: 1307 HSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
+ + + +H A+ GH +++++L+ T N +P++ A GH + +++L
Sbjct: 241 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 300
Query: 1367 ESGASPKSETNL 1378
+G SP ++ L
Sbjct: 301 RNGYSPDAQACL 312
Score = 72.5 bits (170), Expect = 1e-11
Identities = 44/133 (33%), Positives = 71/133 (53%), Gaps = 1/133 (0%)
Query: 657 KYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLL 716
K K F+G ++H AA GH I+ LL+ G + TT + T L +AVE+ + V+ LL
Sbjct: 73 KMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL 132
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
+GA+V+ LH A + + +LL+ GA + G+TP+ VAA++G
Sbjct: 133 QHGANVNGSHSMCGWNSLH-QASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGK 191
Query: 777 LATLVLLLEDGGD 789
L +L +L+ G +
Sbjct: 192 LESLSILISSGAN 204
Score = 59.7 bits (138), Expect = 1e-07
Identities = 45/146 (30%), Positives = 70/146 (47%), Gaps = 5/146 (3%)
Query: 654 FFEKYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVE 713
F E Y D ++ AAR G+V ++ LL+KG SVDV N + +H A ++
Sbjct: 3 FTEAYA--DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQ 60
Query: 714 TLLGYGADVHIRGGKQRE--TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVA 771
L+ + + K E LH+AA K +LL++GA PN T + TP+ +A
Sbjct: 61 MLINADSSENYIKMKTFEGFCALHLAAS-QGHWKIVQILLEAGADPNATTLEETTPLFLA 119
Query: 772 AKFGNLATLVLLLEDGGDPLRKTKVC 797
+ G + L LLL+ G + +C
Sbjct: 120 VENGQIDVLRLLLQHGANVNGSHSMC 145
Score = 58.4 bits (135), Expect = 3e-07
Identities = 42/124 (33%), Positives = 64/124 (51%), Gaps = 4/124 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G S+H A+ + II LL+KG + + + T L +A + K + L+ GA+V
Sbjct: 146 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 205
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPN-KATEDG-MTPVHVAAKFGNLATL 780
+ + + TPL IAA+ KC +LL SGA P+ ED P+H AA+ G+ L
Sbjct: 206 NCQ-ALDKATPLFIAAQ-EGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKIL 263
Query: 781 VLLL 784
LL+
Sbjct: 264 DLLI 267
Score = 55.6 bits (128), Expect = 2e-06
Identities = 42/146 (28%), Positives = 67/146 (45%), Gaps = 2/146 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LAVE G ++R LL A + + G +LH A+ + + ++ ++L+ GA +
Sbjct: 115 PLFLAVENGQIDVLRLLLQ-HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 173
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ G TPL +AA G + AN + TP+ +AA+ GH +ELL
Sbjct: 174 CQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLS 233
Query: 186 KFKASIFERTKDGSTL-MHIASLNGH 210
+D L +H A+ GH
Sbjct: 234 SGADPDLYCNEDSWQLPIHAAAQMGH 259
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/126 (30%), Positives = 61/126 (48%), Gaps = 3/126 (2%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G T L +AA+ ++ IL+ GA V+ TPL IAA EG V+ A+
Sbjct: 179 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADP 238
Query: 158 AIADNED--RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAM 215
+ NED + P+H AA+ GH I++LL + + + + ++ A GH DC
Sbjct: 239 DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRAC-DTGLNKVSPVYSAVFGGHEDCLE 297
Query: 216 MLFKKG 221
+L + G
Sbjct: 298 ILLRNG 303
Score = 52.0 bits (119), Expect = 2e-05
Identities = 42/181 (23%), Positives = 76/181 (41%), Gaps = 5/181 (2%)
Query: 69 LAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA---VVD 125
LA GN ++R+LL + + G +H AA V+ ++L++ + +
Sbjct: 16 LAAREGNVKVLRKLL--KKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIK 73
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
G LH+AA++G +V+ A+ E+ TP+ LA ENG ++ LL
Sbjct: 74 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 133
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDEVLFVKIE 245
+ G +H AS +A+ +L +KG + + F + K+E
Sbjct: 134 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 193
Query: 246 N 246
+
Sbjct: 194 S 194
Score = 48.4 bits (110), Expect = 3e-04
Identities = 36/122 (29%), Positives = 61/122 (50%), Gaps = 3/122 (2%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTND-NYTALHIAVESCKPAVVETLLGYGADVHIRGGK 728
A G + ++ LLQ G +V+ + + + +LH A +++ LL GA+ +
Sbjct: 119 AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDF 178
Query: 729 QRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGG 788
TPL +AA+ + ++ L+ SGA N D TP+ +AA+ G+ + LLL G
Sbjct: 179 GI-TPLFVAAQYGKLESLSI-LISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGA 236
Query: 789 DP 790
DP
Sbjct: 237 DP 238
>AC007883-1|AAY24350.1| 326|Homo sapiens unknown protein.
Length = 326
Score = 104 bits (250), Expect = 3e-21
Identities = 84/268 (31%), Positives = 125/268 (46%), Gaps = 22/268 (8%)
Query: 1138 LAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM----RSTNTLRIS 1193
LAA G+ V+R L++ G S + G +H AA H L ++ S N +++
Sbjct: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAY 1253
+ + G LH+AA G + V+ LL P +L TPL LA
Sbjct: 76 TFE-GFCALHLAASQGHWKIVQILLE------AGADPNATTLEET-------TPLFLAVE 121
Query: 1254 NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHG 1313
NG +V+RLLL G + + + G+N LH A F + I+ LLL + A D G
Sbjct: 122 NGQIDVLRLLLQH-GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANK-ECQDDFG 179
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPK 1373
T L +A+ +G + + +L+ GA +N + TPL AA+ GH V+LL SGA P
Sbjct: 180 ITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD 239
Query: 1374 SETNLNC--APIWFAASENHNDVLEYLL 1399
N + PI AA H +L+ L+
Sbjct: 240 LYCNEDSWQLPIHAAAQMGHTKILDLLI 267
Score = 95.1 bits (226), Expect = 2e-18
Identities = 72/239 (30%), Positives = 117/239 (48%), Gaps = 14/239 (5%)
Query: 1167 TAVHLAAEHGHTNVL-DVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTV 1225
+ V LAA G+ VL +++ ++ ++ + G P+H AAY+ E ++ L++
Sbjct: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNR-GWMPIHEAAYHNSVECLQMLIN------ 64
Query: 1226 KSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHL 1285
A + + + + E G LHLAA G+ +V++LL AG +A + E PL L
Sbjct: 65 ---ADSSENYIKMKTFE-GFCALHLAASQGHWKIVQILLE-AGADPNATTLEET-TPLFL 118
Query: 1286 ACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKN 1345
A G + ++ LLL A + S G LH AS + +++++LL +GA D
Sbjct: 119 AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDF 178
Query: 1346 GWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G TPL AA+ G L + +L SGA+ + P++ AA E H +E LL D
Sbjct: 179 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD 237
Score = 91.5 bits (217), Expect = 3e-17
Identities = 84/315 (26%), Positives = 154/315 (48%), Gaps = 23/315 (7%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA--M 1021
S + LAA G ++V LL ++ G +H AA + ++ LI ++
Sbjct: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENY 71
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
I + T + LHLAA+ G ++ ++LLE GA+ +AT P+ A +N +V++L
Sbjct: 72 IKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLL 131
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
LQ N+ + + G H A+ Q + ++I+ L+ R G TPL +AA+
Sbjct: 132 LQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLL---RKGANKECQDDFGITPLFVAAQ 188
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT---LRISSKKLG 1198
G + + +L+ +GA+ + T + +AA+ GHT ++++ S+ L +
Sbjct: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQ 248
Query: 1199 LTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNEN 1258
L P+H AA G + + +LL +P T ++ TG++ V +P++ A + G+E+
Sbjct: 249 L-PIHAAAQMGHTK-ILDLL--IPLTNRA-CDTGLNKV---------SPVYSAVFGGHED 294
Query: 1259 VVRLLLNSAGVQADA 1273
+ +LL + G DA
Sbjct: 295 CLEILLRN-GYSPDA 308
Score = 90.6 bits (215), Expect = 5e-17
Identities = 72/271 (26%), Positives = 126/271 (46%), Gaps = 11/271 (4%)
Query: 920 RALNRQNSIGWTPLLIACHRGHMQLVNTLLT-----NHARVDVFDVEGRSALHLAAEHGY 974
R+++ ++ GW P+ A + ++ + L+ N+ ++ F EG ALHLAA G+
Sbjct: 34 RSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTF--EGFCALHLAASQGH 91
Query: 975 LQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMID-VLTLKKQTPL 1033
++ LL A N+ T L LA NG +++ L++ H A ++ ++ L
Sbjct: 92 WKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ-HGANVNGSHSMCGWNSL 150
Query: 1034 HLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT 1093
H A+ E+ KLLL GAN + D+ G P+ AAQ E + + + N V
Sbjct: 151 HQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGAN-VNCQA 209
Query: 1094 KDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR 1153
D T IAA +G K +E L+ + N+ + P+ AA+ GH ++ +L+
Sbjct: 210 LDKATPLFIAAQEGHTKCVELLLSSGADPDLYC-NEDSWQLPIHAAAQMGHTKILDLLIP 268
Query: 1154 AGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
D ++ V+ A GH + L+++
Sbjct: 269 LTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 299
Score = 84.2 bits (199), Expect = 4e-15
Identities = 80/312 (25%), Positives = 142/312 (45%), Gaps = 18/312 (5%)
Query: 1069 AAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
AA+ +V++ L++ ++ +A + G H AA SV+ ++ L+ D +
Sbjct: 17 AAREGNVKVLRKLLKKGRSVDVADNR-GWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTN 1188
L LAA GH +V++L+ AGA T + LA E+G +VL ++
Sbjct: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
Query: 1189 T-LRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+ S G LH A++ AE ++ LL G K + G+TP
Sbjct: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK--GANKE-----------CQDDFGITP 182
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL-L 1306
L +AA G + +L++S G + + + PL +A GH V LLLS A+ L
Sbjct: 183 LFVAAQYGKLESLSILISS-GANVNCQALDKA-TPLFIAAQEGHTKCVELLLSSGADPDL 240
Query: 1307 HSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
+ + + +H A+ GH +++++L+ T N +P++ A GH + +++L
Sbjct: 241 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 300
Query: 1367 ESGASPKSETNL 1378
+G SP ++ L
Sbjct: 301 RNGYSPDAQACL 312
Score = 72.5 bits (170), Expect = 1e-11
Identities = 44/133 (33%), Positives = 71/133 (53%), Gaps = 1/133 (0%)
Query: 657 KYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLL 716
K K F+G ++H AA GH I+ LL+ G + TT + T L +AVE+ + V+ LL
Sbjct: 73 KMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL 132
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
+GA+V+ LH A + + +LL+ GA + G+TP+ VAA++G
Sbjct: 133 QHGANVNGSHSMCGWNSLH-QASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGK 191
Query: 777 LATLVLLLEDGGD 789
L +L +L+ G +
Sbjct: 192 LESLSILISSGAN 204
Score = 59.7 bits (138), Expect = 1e-07
Identities = 45/146 (30%), Positives = 70/146 (47%), Gaps = 5/146 (3%)
Query: 654 FFEKYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVE 713
F E Y D ++ AAR G+V ++ LL+KG SVDV N + +H A ++
Sbjct: 3 FTEAYA--DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQ 60
Query: 714 TLLGYGADVHIRGGKQRE--TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVA 771
L+ + + K E LH+AA K +LL++GA PN T + TP+ +A
Sbjct: 61 MLINADSSENYIKMKTFEGFCALHLAAS-QGHWKIVQILLEAGADPNATTLEETTPLFLA 119
Query: 772 AKFGNLATLVLLLEDGGDPLRKTKVC 797
+ G + L LLL+ G + +C
Sbjct: 120 VENGQIDVLRLLLQHGANVNGSHSMC 145
Score = 58.4 bits (135), Expect = 3e-07
Identities = 42/124 (33%), Positives = 64/124 (51%), Gaps = 4/124 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G S+H A+ + II LL+KG + + + T L +A + K + L+ GA+V
Sbjct: 146 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 205
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPN-KATEDG-MTPVHVAAKFGNLATL 780
+ + + TPL IAA+ KC +LL SGA P+ ED P+H AA+ G+ L
Sbjct: 206 NCQ-ALDKATPLFIAAQ-EGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKIL 263
Query: 781 VLLL 784
LL+
Sbjct: 264 DLLI 267
Score = 55.6 bits (128), Expect = 2e-06
Identities = 42/146 (28%), Positives = 67/146 (45%), Gaps = 2/146 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LAVE G ++R LL A + + G +LH A+ + + ++ ++L+ GA +
Sbjct: 115 PLFLAVENGQIDVLRLLLQ-HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 173
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ G TPL +AA G + AN + TP+ +AA+ GH +ELL
Sbjct: 174 CQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLS 233
Query: 186 KFKASIFERTKDGSTL-MHIASLNGH 210
+D L +H A+ GH
Sbjct: 234 SGADPDLYCNEDSWQLPIHAAAQMGH 259
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/126 (30%), Positives = 61/126 (48%), Gaps = 3/126 (2%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G T L +AA+ ++ IL+ GA V+ TPL IAA EG V+ A+
Sbjct: 179 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADP 238
Query: 158 AIADNED--RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAM 215
+ NED + P+H AA+ GH I++LL + + + + ++ A GH DC
Sbjct: 239 DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRAC-DTGLNKVSPVYSAVFGGHEDCLE 297
Query: 216 MLFKKG 221
+L + G
Sbjct: 298 ILLRNG 303
Score = 52.0 bits (119), Expect = 2e-05
Identities = 42/181 (23%), Positives = 76/181 (41%), Gaps = 5/181 (2%)
Query: 69 LAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA---VVD 125
LA GN ++R+LL + + G +H AA V+ ++L++ + +
Sbjct: 16 LAAREGNVKVLRKLL--KKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIK 73
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
G LH+AA++G +V+ A+ E+ TP+ LA ENG ++ LL
Sbjct: 74 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 133
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDEVLFVKIE 245
+ G +H AS +A+ +L +KG + + F + K+E
Sbjct: 134 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 193
Query: 246 N 246
+
Sbjct: 194 S 194
Score = 48.4 bits (110), Expect = 3e-04
Identities = 36/122 (29%), Positives = 61/122 (50%), Gaps = 3/122 (2%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTND-NYTALHIAVESCKPAVVETLLGYGADVHIRGGK 728
A G + ++ LLQ G +V+ + + + +LH A +++ LL GA+ +
Sbjct: 119 AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDF 178
Query: 729 QRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGG 788
TPL +AA+ + ++ L+ SGA N D TP+ +AA+ G+ + LLL G
Sbjct: 179 GI-TPLFVAAQYGKLESLSI-LISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGA 236
Query: 789 DP 790
DP
Sbjct: 237 DP 238
>AB209795-1|BAD93032.1| 340|Homo sapiens ankyrin repeat and SOCS
box-containing protein 3 isoform a variant protein.
Length = 340
Score = 104 bits (250), Expect = 3e-21
Identities = 84/268 (31%), Positives = 125/268 (46%), Gaps = 22/268 (8%)
Query: 1138 LAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM----RSTNTLRIS 1193
LAA G+ V+R L++ G S + G +H AA H L ++ S N +++
Sbjct: 26 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 85
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAY 1253
+ + G LH+AA G + V+ LL P +L TPL LA
Sbjct: 86 TFE-GFCALHLAASQGHWKIVQILLE------AGADPNATTLEET-------TPLFLAVE 131
Query: 1254 NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHG 1313
NG +V+RLLL G + + + G+N LH A F + I+ LLL + A D G
Sbjct: 132 NGQIDVLRLLLQH-GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANK-ECQDDFG 189
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPK 1373
T L +A+ +G + + +L+ GA +N + TPL AA+ GH V+LL SGA P
Sbjct: 190 ITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD 249
Query: 1374 SETNLNC--APIWFAASENHNDVLEYLL 1399
N + PI AA H +L+ L+
Sbjct: 250 LYCNEDSWQLPIHAAAQMGHTKILDLLI 277
Score = 95.1 bits (226), Expect = 2e-18
Identities = 72/239 (30%), Positives = 117/239 (48%), Gaps = 14/239 (5%)
Query: 1167 TAVHLAAEHGHTNVL-DVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTV 1225
+ V LAA G+ VL +++ ++ ++ + G P+H AAY+ E ++ L++
Sbjct: 22 STVGLAAREGNVKVLRKLLKKGRSVDVADNR-GWMPIHEAAYHNSVECLQMLIN------ 74
Query: 1226 KSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHL 1285
A + + + + E G LHLAA G+ +V++LL AG +A + E PL L
Sbjct: 75 ---ADSSENYIKMKTFE-GFCALHLAASQGHWKIVQILLE-AGADPNATTLEET-TPLFL 128
Query: 1286 ACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKN 1345
A G + ++ LLL A + S G LH AS + +++++LL +GA D
Sbjct: 129 AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDF 188
Query: 1346 GWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G TPL AA+ G L + +L SGA+ + P++ AA E H +E LL D
Sbjct: 189 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD 247
Score = 91.5 bits (217), Expect = 3e-17
Identities = 84/315 (26%), Positives = 154/315 (48%), Gaps = 23/315 (7%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA--M 1021
S + LAA G ++V LL ++ G +H AA + ++ LI ++
Sbjct: 22 STVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENY 81
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
I + T + LHLAA+ G ++ ++LLE GA+ +AT P+ A +N +V++L
Sbjct: 82 IKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLL 141
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
LQ N+ + + G H A+ Q + ++I+ L+ R G TPL +AA+
Sbjct: 142 LQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLL---RKGANKECQDDFGITPLFVAAQ 198
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT---LRISSKKLG 1198
G + + +L+ +GA+ + T + +AA+ GHT ++++ S+ L +
Sbjct: 199 YGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQ 258
Query: 1199 LTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNEN 1258
L P+H AA G + + +LL +P T ++ TG++ V +P++ A + G+E+
Sbjct: 259 L-PIHAAAQMGHTK-ILDLL--IPLTNRA-CDTGLNKV---------SPVYSAVFGGHED 304
Query: 1259 VVRLLLNSAGVQADA 1273
+ +LL + G DA
Sbjct: 305 CLEILLRN-GYSPDA 318
Score = 90.6 bits (215), Expect = 5e-17
Identities = 72/271 (26%), Positives = 126/271 (46%), Gaps = 11/271 (4%)
Query: 920 RALNRQNSIGWTPLLIACHRGHMQLVNTLLT-----NHARVDVFDVEGRSALHLAAEHGY 974
R+++ ++ GW P+ A + ++ + L+ N+ ++ F EG ALHLAA G+
Sbjct: 44 RSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTF--EGFCALHLAASQGH 101
Query: 975 LQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMID-VLTLKKQTPL 1033
++ LL A N+ T L LA NG +++ L++ H A ++ ++ L
Sbjct: 102 WKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ-HGANVNGSHSMCGWNSL 160
Query: 1034 HLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT 1093
H A+ E+ KLLL GAN + D+ G P+ AAQ E + + + N V
Sbjct: 161 HQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGAN-VNCQA 219
Query: 1094 KDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR 1153
D T IAA +G K +E L+ + N+ + P+ AA+ GH ++ +L+
Sbjct: 220 LDKATPLFIAAQEGHTKCVELLLSSGADPDLYC-NEDSWQLPIHAAAQMGHTKILDLLIP 278
Query: 1154 AGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
D ++ V+ A GH + L+++
Sbjct: 279 LTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 309
Score = 84.2 bits (199), Expect = 4e-15
Identities = 80/312 (25%), Positives = 142/312 (45%), Gaps = 18/312 (5%)
Query: 1069 AAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
AA+ +V++ L++ ++ +A + G H AA SV+ ++ L+ D +
Sbjct: 27 AAREGNVKVLRKLLKKGRSVDVADNR-GWMPIHEAAYHNSVECLQMLINADSSENYIKMK 85
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTN 1188
L LAA GH +V++L+ AGA T + LA E+G +VL ++
Sbjct: 86 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 145
Query: 1189 T-LRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+ S G LH A++ AE ++ LL G K + G+TP
Sbjct: 146 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK--GANKE-----------CQDDFGITP 192
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL-L 1306
L +AA G + +L++S G + + + PL +A GH V LLLS A+ L
Sbjct: 193 LFVAAQYGKLESLSILISS-GANVNCQALDKA-TPLFIAAQEGHTKCVELLLSSGADPDL 250
Query: 1307 HSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
+ + + +H A+ GH +++++L+ T N +P++ A GH + +++L
Sbjct: 251 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 310
Query: 1367 ESGASPKSETNL 1378
+G SP ++ L
Sbjct: 311 RNGYSPDAQACL 322
Score = 72.5 bits (170), Expect = 1e-11
Identities = 44/133 (33%), Positives = 71/133 (53%), Gaps = 1/133 (0%)
Query: 657 KYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLL 716
K K F+G ++H AA GH I+ LL+ G + TT + T L +AVE+ + V+ LL
Sbjct: 83 KMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL 142
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
+GA+V+ LH A + + +LL+ GA + G+TP+ VAA++G
Sbjct: 143 QHGANVNGSHSMCGWNSLH-QASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGK 201
Query: 777 LATLVLLLEDGGD 789
L +L +L+ G +
Sbjct: 202 LESLSILISSGAN 214
Score = 60.1 bits (139), Expect = 8e-08
Identities = 46/153 (30%), Positives = 73/153 (47%), Gaps = 5/153 (3%)
Query: 647 RMIFWDTFFEKYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVES 706
R++ F E Y D ++ AAR G+V ++ LL+KG SVDV N + +H A
Sbjct: 6 RLVKQMDFTEAYA--DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYH 63
Query: 707 CKPAVVETLLGYGADVHIRGGKQRE--TPLHIAARIPDGDKCALMLLKSGAGPNKATEDG 764
++ L+ + + K E LH+AA K +LL++GA PN T +
Sbjct: 64 NSVECLQMLINADSSENYIKMKTFEGFCALHLAAS-QGHWKIVQILLEAGADPNATTLEE 122
Query: 765 MTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVC 797
TP+ +A + G + L LLL+ G + +C
Sbjct: 123 TTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC 155
Score = 58.4 bits (135), Expect = 3e-07
Identities = 42/124 (33%), Positives = 64/124 (51%), Gaps = 4/124 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G S+H A+ + II LL+KG + + + T L +A + K + L+ GA+V
Sbjct: 156 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 215
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPN-KATEDG-MTPVHVAAKFGNLATL 780
+ + + TPL IAA+ KC +LL SGA P+ ED P+H AA+ G+ L
Sbjct: 216 NCQ-ALDKATPLFIAAQ-EGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKIL 273
Query: 781 VLLL 784
LL+
Sbjct: 274 DLLI 277
Score = 55.6 bits (128), Expect = 2e-06
Identities = 42/146 (28%), Positives = 67/146 (45%), Gaps = 2/146 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LAVE G ++R LL A + + G +LH A+ + + ++ ++L+ GA +
Sbjct: 125 PLFLAVENGQIDVLRLLLQ-HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 183
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ G TPL +AA G + AN + TP+ +AA+ GH +ELL
Sbjct: 184 CQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLS 243
Query: 186 KFKASIFERTKDGSTL-MHIASLNGH 210
+D L +H A+ GH
Sbjct: 244 SGADPDLYCNEDSWQLPIHAAAQMGH 269
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/126 (30%), Positives = 61/126 (48%), Gaps = 3/126 (2%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G T L +AA+ ++ IL+ GA V+ TPL IAA EG V+ A+
Sbjct: 189 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADP 248
Query: 158 AIADNED--RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAM 215
+ NED + P+H AA+ GH I++LL + + + + ++ A GH DC
Sbjct: 249 DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRAC-DTGLNKVSPVYSAVFGGHEDCLE 307
Query: 216 MLFKKG 221
+L + G
Sbjct: 308 ILLRNG 313
Score = 52.0 bits (119), Expect = 2e-05
Identities = 42/181 (23%), Positives = 76/181 (41%), Gaps = 5/181 (2%)
Query: 69 LAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA---VVD 125
LA GN ++R+LL + + G +H AA V+ ++L++ + +
Sbjct: 26 LAAREGNVKVLRKLL--KKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIK 83
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
G LH+AA++G +V+ A+ E+ TP+ LA ENG ++ LL
Sbjct: 84 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 143
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDEVLFVKIE 245
+ G +H AS +A+ +L +KG + + F + K+E
Sbjct: 144 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 203
Query: 246 N 246
+
Sbjct: 204 S 204
Score = 48.4 bits (110), Expect = 3e-04
Identities = 36/122 (29%), Positives = 61/122 (50%), Gaps = 3/122 (2%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTND-NYTALHIAVESCKPAVVETLLGYGADVHIRGGK 728
A G + ++ LLQ G +V+ + + + +LH A +++ LL GA+ +
Sbjct: 129 AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDF 188
Query: 729 QRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGG 788
TPL +AA+ + ++ L+ SGA N D TP+ +AA+ G+ + LLL G
Sbjct: 189 GI-TPLFVAAQYGKLESLSI-LISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGA 246
Query: 789 DP 790
DP
Sbjct: 247 DP 248
>BC032354-1|AAH32354.1| 587|Homo sapiens ankyrin repeat and SOCS
box-containing 2 protein.
Length = 587
Score = 104 bits (249), Expect = 4e-21
Identities = 83/309 (26%), Positives = 142/309 (45%), Gaps = 20/309 (6%)
Query: 1032 PLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
PL A G E K +++ G N+ ++ G P+H AA +++ + +P +
Sbjct: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
T T ++A +G + + L++ IS +++ TPL A E +A+ V++L
Sbjct: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSR---ETPLYKACERKNAEAVKIL 176
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQA 1211
V+ A G TA+H + V+ ++ S S G+TPL +AA GQ
Sbjct: 177 VQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQL 236
Query: 1212 ETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQA 1271
E +R L+ + ++A S L+ A N +E VV LL S G A
Sbjct: 237 EALR-FLAKYGADINTQASDNAS------------ALYEACKNEHEEVVEFLL-SQGADA 282
Query: 1272 DAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEV 1331
+ +N++G PLH+A G+ IV +LL ++ R G + LH+A+ H +++E
Sbjct: 283 N-KTNKDGLLPLHIASKKGNYRIVQMLLPVTSRT--RIRRSGVSPLHLAAERNHDEVLEA 339
Query: 1332 LLGQGAEIN 1340
LL ++N
Sbjct: 340 LLSARFDVN 348
Score = 95.5 bits (227), Expect = 2e-18
Identities = 77/297 (25%), Positives = 138/297 (46%), Gaps = 17/297 (5%)
Query: 1172 AAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT 1231
A + G L M K G PLH AAYYGQ ++ L PGT+
Sbjct: 64 AIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRT-- 121
Query: 1232 GVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGH 1291
L E T ++LA G+ + + LL AG + D SN++ PL+ AC +
Sbjct: 122 -------LQEE---TAVYLATCRGHLDCLLSLLQ-AGAEPDI-SNKSRETPLYKACERKN 169
Query: 1292 MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLH 1351
V +L+ +A+ H +R G T LH + + +++++L+ GA++ + + G TPL
Sbjct: 170 AEAVKILVQHNADTNHRCNR-GWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLF 228
Query: 1352 CAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDD 1411
AA++G L ++ L + GA ++ + N + ++ A H +V+E+LL + D +
Sbjct: 229 VAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANK--TN 286
Query: 1412 KRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKERAKDLIAA 1468
K + L + SK N ++ + V+ + +S +++ E + L++A
Sbjct: 287 KDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSA 343
Score = 95.5 bits (227), Expect = 2e-18
Identities = 80/280 (28%), Positives = 128/280 (45%), Gaps = 18/280 (6%)
Query: 1135 PLQLAAEGGHADVVRVLVRAGASCTDENRAGL-TAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
PL AA G ++VL RA D+ TAV+LA GH + L +
Sbjct: 93 PLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDI 152
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAY 1253
S K TPL+ A AE V+ L+ H T G T LH +
Sbjct: 153 SNKSRETPLYKACERKNAEAVKILVQHNADTNHR-------------CNRGWTALHESVS 199
Query: 1254 NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHG 1313
+ V+++L+ S G + ++ N G PL +A G + + L A++ ++
Sbjct: 200 RNDLEVMQILV-SGGAKVES-KNAYGITPLFVAAQSGQLEALRFLAKYGADI-NTQASDN 256
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPK 1373
+ L+ A + H ++VE LL QGA+ N T+K+G PLH A+K G+ +V++L + +
Sbjct: 257 ASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTR 316
Query: 1374 SETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKR 1413
+ +P+ AA NH++VLE LL D + + +R
Sbjct: 317 IRRS-GVSPLHLAAERNHDEVLEALLSARFDVNTPLAPER 355
Score = 93.9 bits (223), Expect = 6e-18
Identities = 76/294 (25%), Positives = 137/294 (46%), Gaps = 18/294 (6%)
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMI-AHISTADVSRAL 922
I D + +K +I+ G +++ + H A G + + A+ T D R L
Sbjct: 65 IKDGDEEALKTMIKEGKNLAEPNKEGW-LPLHEAAYYGQVGCLKVLQRAYPGTID-QRTL 122
Query: 923 NRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALL 982
+ ++ L C RGH+ + +LL A D+ + + L+ A E + L+
Sbjct: 123 QEETAV----YLATC-RGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILV 177
Query: 983 TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQI 1042
+ A N + G TALH + +++ L+ A ++ TPL +AA SGQ+
Sbjct: 178 QHNADTNHRCNRGWTALHESVSRNDLEVMQILVSG-GAKVESKNAYGITPLFVAAQSGQL 236
Query: 1043 EVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHI 1102
E + L + GA+I+ ++ A +N + EVV+ L Q + T KDG HI
Sbjct: 237 EALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGAD-ANKTNKDGLLPLHI 295
Query: 1103 AAIQGSVKVIEELMKFDRTGVISARNKLNDS--TPLQLAAEGGHADVVRVLVRA 1154
A+ +G+ ++++ L+ +++R ++ S +PL LAAE H +V+ L+ A
Sbjct: 296 ASKKGNYRIVQMLLP------VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSA 343
Score = 77.8 bits (183), Expect = 4e-13
Identities = 102/405 (25%), Positives = 174/405 (42%), Gaps = 52/405 (12%)
Query: 662 DGARSIHTAARYGHVGIINTLLQK-GESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
+G +H AA YG VG + L + ++D T TA+++A + +LL GA
Sbjct: 89 EGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGA 148
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
+ I K RETPL+ A + + +L++ A N G T +H + +L +
Sbjct: 149 EPDI-SNKSRETPLYKACERKNAE-AVKILVQHNADTNHRCNRGWTALHESVSRNDLEVM 206
Query: 781 VLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFI 840
+L+ G K G TPL +A +S + +R L ++ D I
Sbjct: 207 QILVSGGAKVESKN-------AYGITPLFVAAQSGQLEALRFLAKYGAD----------I 249
Query: 841 DAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIA 900
+ D ASAL+ ACK EE VV+ L+ GAD + +T + H +
Sbjct: 250 NTQASDNASALYEACKNEHEE---------VVEFLLSQGADAN-KTNKDGLLPLHIASKK 299
Query: 901 GNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH-------- 952
GN ++ ++ S + R+ G +PL +A R H +++ LL+
Sbjct: 300 GNYRIVQMLLPVTSRTRIRRS-------GVSPLHLAAERNHDEVLEALLSARFDVNTPLA 352
Query: 953 -ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLV 1011
R +++ SAL+ A + + + LL + A N R+ + L +A +G +
Sbjct: 353 PERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTM 409
Query: 1012 KFLIRDHNAMID--VLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
+ L+ DH A ID + T P + A + + K L++LG +
Sbjct: 410 QLLL-DHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCD 453
Score = 73.7 bits (173), Expect = 6e-12
Identities = 106/410 (25%), Positives = 182/410 (44%), Gaps = 51/410 (12%)
Query: 676 VGIINTLLQKGESVDVTTNDNYTA--LHIAVESCKPAVVETLLGYGADVHIRGGKQRETP 733
+G+ ++QK S T+ A L A++ ++T++ G ++ K+ P
Sbjct: 35 MGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNL-AEPNKEGWLP 93
Query: 734 LHIAARIPDGDKCALMLLKSGAGP-NKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLR 792
LH AA C +L ++ G ++ T T V++A G+L L+ LL+ G +P
Sbjct: 94 LHEAAYYGQVG-CLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDI 152
Query: 793 KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKD--HKGESVSTAFIDAVDEDGASA 850
K + ETPL AC + V+ L++ D H+ TA ++V +
Sbjct: 153 SNK-------SRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEV 205
Query: 851 LHY------------ACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
+ A +T V + + ++ L + GAD++ Q N + C
Sbjct: 206 MQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACK 265
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVF 958
++ + E + AD N+ N G PL IA +G+ ++V LL +R +
Sbjct: 266 --NEHEEVVEFLLS-QGADA----NKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR 318
Query: 959 DVEGRSALHLAAEHGYLQVCDALLTNKAFINS-----KAR----NGRTALHLAAMNGYAH 1009
G S LHLAAE + +V +ALL+ + +N+ +AR +AL+ A +N +
Sbjct: 319 R-SGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVY 377
Query: 1010 LVKFLIRDHNA--MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDA 1057
+ L++ H A DV+ +PL +A G + +LLL+ GANIDA
Sbjct: 378 ATELLLQ-HGADPNRDVI-----SPLLVAIRHGCLRTMQLLLDHGANIDA 421
Score = 70.1 bits (164), Expect = 8e-11
Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 7/163 (4%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D+ + + PL A E N V+ L+ + G TALH + R D+++ +I
Sbjct: 151 DISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNR--GWTALHESVSRNDLEVMQI 208
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYF--YGVRANAAIADNEDRTPMHLAAEN 174
LV GA V++ N G TPL +AA G +++ YG N +DN + ++ A +N
Sbjct: 209 LVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDN--ASALYEACKN 266
Query: 175 GHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
H ++E L + A + KDG +HIAS G+ ML
Sbjct: 267 EHEEVVEFLLSQ-GADANKTNKDGLLPLHIASKKGNYRIVQML 308
Score = 56.8 bits (131), Expect = 8e-07
Identities = 37/126 (29%), Positives = 62/126 (49%), Gaps = 4/126 (3%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL +A ++G +R L A+ + +AL+ A + ++ L+ GA
Sbjct: 223 GITPLFVAAQSGQLEALRFL--AKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGA 280
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE- 181
+ TN G PLHIA+ +G+ +V+ V + I +P+HLAAE H ++E
Sbjct: 281 DANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR-RSGVSPLHLAAERNHDEVLEA 339
Query: 182 LLADKF 187
LL+ +F
Sbjct: 340 LLSARF 345
Score = 53.6 bits (123), Expect = 7e-06
Identities = 40/145 (27%), Positives = 70/145 (48%), Gaps = 6/145 (4%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ G + AA+ G + + L + G ++ +DN +AL+ A ++ VVE LL
Sbjct: 219 KNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQ 278
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
GAD + + K PLHIA++ G+ + +L + G++P+H+AA+ +
Sbjct: 279 GADAN-KTNKDGLLPLHIASK--KGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDE 335
Query: 779 TLVLLLE---DGGDPLRKTKVCIYD 800
L LL D PL + +Y+
Sbjct: 336 VLEALLSARFDVNTPLAPERARLYE 360
Score = 52.8 bits (121), Expect = 1e-05
Identities = 29/96 (30%), Positives = 46/96 (47%)
Query: 134 PLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFE 193
PL A +GDE +K N A + E P+H AA G +++L + +I +
Sbjct: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
Query: 194 RTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
RT T +++A+ GH DC + L + G + NK
Sbjct: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNK 155
Score = 43.2 bits (97), Expect = 0.010
Identities = 38/161 (23%), Positives = 67/161 (41%), Gaps = 2/161 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G +PL A G ++ L A + T +TA++LA R +D L+
Sbjct: 88 KEGWLPLHEAAYYGQVGCLKVLQRAYPGT-IDQRTLQEETAVYLATCRGHLDCLLSLLQA 146
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA D +N + +TPL+ A + VK A+ N T +H + ++
Sbjct: 147 GAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVM 206
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
++L A + + G T + +A+ +G + L K G
Sbjct: 207 QILVSG-GAKVESKNAYGITPLFVAAQSGQLEALRFLAKYG 246
Score = 35.5 bits (78), Expect = 2.1
Identities = 25/105 (23%), Positives = 45/105 (42%), Gaps = 1/105 (0%)
Query: 1296 GLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAK 1355
G++ S+ L ++ L A G + ++ ++ +G + +K GW PLH AA
Sbjct: 40 GVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAY 99
Query: 1356 AGHLNVVKLLCESGASPKSETNL-NCAPIWFAASENHNDVLEYLL 1399
G + +K+L + + L ++ A H D L LL
Sbjct: 100 YGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLL 144
>BC030622-1|AAH30622.1| 301|Homo sapiens ankyrin repeat domain 29
protein.
Length = 301
Score = 104 bits (249), Expect = 4e-21
Identities = 76/259 (29%), Positives = 127/259 (49%), Gaps = 12/259 (4%)
Query: 875 LIENGADVSLQTRHNHETAF-HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPL 933
L+ N V + R +H T A AG+ D + E++ + AD+ N Q G T L
Sbjct: 30 LLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELV--LQGADI----NLQRESGTTAL 83
Query: 934 LIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKAR 993
A +GH +V L A + + +AL A+++G++QV + LL + A I+ +
Sbjct: 84 FFAAQQGHNDVVRFLFGFGASTEFRTKDEGTALLAASQYGHMQVVETLLKHGANIHDQLY 143
Query: 994 NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA 1053
+G TAL LAA GY +++ L+ A ++ PL +A+ G EV +++L GA
Sbjct: 144 DGATALFLAAQGGYLDVIRLLLAS-GAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGA 202
Query: 1054 NIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIE 1113
+ DA G + AA Y++V++ L+ P L K+G + H A + G++K +
Sbjct: 203 DRDAARNDGTTALLKAANKGYNDVIKELLKFSPTL--GILKNGTSALHAAVLSGNIKTVA 260
Query: 1114 ELMKFDRTGVISARNKLND 1132
L++ S RNK N+
Sbjct: 261 LLLEAGADP--SLRNKANE 277
Score = 102 bits (244), Expect = 2e-20
Identities = 93/305 (30%), Positives = 141/305 (46%), Gaps = 22/305 (7%)
Query: 1103 AAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDEN 1162
AA +G++ +++ L+ R V R+ + +T L +AA GH D VR LV GA +
Sbjct: 19 AARRGNLALLKLLLNSGRVDV-DCRDS-HGTTLLMVAAYAGHIDCVRELVLQGADINLQR 76
Query: 1163 RAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVP 1222
+G TA+ AA+ GH +V+ + K T L A+ YG + V LL H
Sbjct: 77 ESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDEGTALLAASQYGHMQVVETLLKH-- 134
Query: 1223 GTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNP 1282
G ++ L G T L LAA G +V+RLLL S G + + ++G P
Sbjct: 135 ---------GANIHDQL--YDGATALFLAAQGGYLDVIRLLLAS-GAKVNQP-RQDGTAP 181
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINAT 1342
L +A GH +V ++L R A+ + G T L A+ G+ +++ LL +
Sbjct: 182 LWIASQMGHSEVVRVMLLRGADR-DAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL 240
Query: 1343 DKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKE 1402
KNG + LH A +G++ V LL E+GA P N P +E +L L KE
Sbjct: 241 -KNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNER---ILRLLRSKE 296
Query: 1403 HDTQS 1407
+S
Sbjct: 297 GPRKS 301
Score = 100 bits (239), Expect = 6e-20
Identities = 76/241 (31%), Positives = 123/241 (51%), Gaps = 8/241 (3%)
Query: 925 QNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTN 984
++S G T L++A + GH+ V L+ A +++ G +AL AA+ G+ V L
Sbjct: 42 RDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGF 101
Query: 985 KAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEV 1044
A + ++ TAL A+ G+ +V+ L++ H A I T L LAA G ++V
Sbjct: 102 GASTEFRTKDEGTALLAASQYGHMQVVETLLK-HGANIHDQLYDGATALFLAAQGGYLDV 160
Query: 1045 CKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
+LLL GA ++ + G P+ A+Q +SEVV++ L + + A DG T AA
Sbjct: 161 IRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRD-AARNDGTTALLKAA 219
Query: 1105 IQGSVKVIEELMKFDRT-GVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENR 1163
+G VI+EL+KF T G++ N ++ L A G+ V +L+ AGA + N+
Sbjct: 220 NKGYNDVIKELLKFSPTLGILK-----NGTSALHAAVLSGNIKTVALLLEAGADPSLRNK 274
Query: 1164 A 1164
A
Sbjct: 275 A 275
Score = 95.9 bits (228), Expect = 1e-18
Identities = 83/278 (29%), Positives = 132/278 (47%), Gaps = 21/278 (7%)
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
AA G L+K L+ +D T L +AA +G I+ + L+ GA+I+ E
Sbjct: 19 AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
G + AAQ +++VV+ FL TKD T A+ G ++V+E L+K
Sbjct: 79 GTTALFFAAQQGHNDVVR-FLFGFGASTEFRTKDEGTALLAASQYGHMQVVETLLKHGA- 136
Query: 1122 GVISARNKLND-STPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNV 1180
+ ++L D +T L LAA+GG+ DV+R+L+ +GA + G + +A++ GH+ V
Sbjct: 137 ---NIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEV 193
Query: 1181 LDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLG 1240
+ VM R +++ G T L AA G + ++ELL P G+
Sbjct: 194 VRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSP-------TLGI------- 239
Query: 1241 AESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNEN 1278
++G + LH A +GN V LLL AG + N
Sbjct: 240 LKNGTSALHAAVLSGNIKTVALLL-EAGADPSLRNKAN 276
Score = 92.7 bits (220), Expect = 1e-17
Identities = 66/196 (33%), Positives = 97/196 (49%), Gaps = 7/196 (3%)
Query: 1244 GLTPLHLAAYNGNENVVR-LLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRS 1302
G T L +AAY G+ + VR L+L A + E+G L A GH +V L
Sbjct: 46 GTTLLMVAAYAGHIDCVRELVLQGADINLQ---RESGTTALFFAAQQGHNDVVRFLFGFG 102
Query: 1303 AELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVV 1362
A T G T L AS +GH Q+VE LL GA I+ +G T L AA+ G+L+V+
Sbjct: 103 ASTEFRTKDEG-TALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVI 161
Query: 1363 KLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCS 1422
+LL SGA AP+W A+ H++V+ +L + D + +D L +
Sbjct: 162 RLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTAL-LKAAN 220
Query: 1423 KNHNNIPIEEFVLVSP 1438
K +N++ I+E + SP
Sbjct: 221 KGYNDV-IKELLKFSP 235
Score = 91.1 bits (216), Expect = 4e-17
Identities = 75/264 (28%), Positives = 123/264 (46%), Gaps = 18/264 (6%)
Query: 1168 AVHLAAEHGHTNVLDVMRSTNTLRISSKKL-GLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
A AA G+ +L ++ ++ + + + G T L +AAY G + VREL+
Sbjct: 15 AAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQ------ 68
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
G + L ESG T L AA G+ +VVR L G + + + G L A
Sbjct: 69 -----GADIN--LQRESGTTALFFAAQQGHNDVVRFLF-GFGASTEFRTKDEG-TALLAA 119
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
GHM +V LL A +H G T L +A+ G+ ++ +LL GA++N ++G
Sbjct: 120 SQYGHMQVVETLLKHGAN-IHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDG 178
Query: 1347 WTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQ 1406
PL A++ GH VV+++ GA + N + AA++ +NDV++ LL K T
Sbjct: 179 TAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELL-KFSPTL 237
Query: 1407 SLMDDKRFVYNLMVCSKNHNNIPI 1430
++ + + V S N + +
Sbjct: 238 GILKNGTSALHAAVLSGNIKTVAL 261
Score = 84.2 bits (199), Expect = 4e-15
Identities = 76/251 (30%), Positives = 121/251 (48%), Gaps = 9/251 (3%)
Query: 936 ACHRGHMQLVNTLLTNHARVDVF--DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKAR 993
A RG++ L+ LL N RVDV D G + L +AA G++ L+ A IN +
Sbjct: 19 AARRGNLALLKLLL-NSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRE 77
Query: 994 NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA 1053
+G TAL AA G+ +V+FL A + T + T L A+ G ++V + LL+ GA
Sbjct: 78 SGTTALFFAAQQGHNDVVRFLF-GFGASTEFRTKDEGTALLAASQYGHMQVVETLLKHGA 136
Query: 1054 NIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIE 1113
NI G + AAQ Y +V++L L V +DG IA+ G +V+
Sbjct: 137 NIHDQLYDGATALFLAAQGGYLDVIRLLLASGAK-VNQPRQDGTAPLWIASQMGHSEVV- 194
Query: 1114 ELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAA 1173
+M +ARN + +T L AA G+ DV++ L++ + + G +A+H A
Sbjct: 195 RVMLLRGADRDAARN--DGTTALLKAANKGYNDVIKELLKFSPT-LGILKNGTSALHAAV 251
Query: 1174 EHGHTNVLDVM 1184
G+ + ++
Sbjct: 252 LSGNIKTVALL 262
Score = 84.2 bits (199), Expect = 4e-15
Identities = 67/212 (31%), Positives = 104/212 (49%), Gaps = 9/212 (4%)
Query: 872 VKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWT 931
V+ L+ GAD++LQ R + TA + A G+NDV+ + ++ + R G T
Sbjct: 62 VRELVLQGADINLQ-RESGTTALFFAAQQGHNDVVRFLFGFGASTEF-----RTKDEG-T 114
Query: 932 PLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSK 991
LL A GHMQ+V TLL + A + +G +AL LAA+ GYL V LL + A +N
Sbjct: 115 ALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQP 174
Query: 992 ARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLEL 1051
++G L +A+ G++ +V+ ++ A D T L AA G +V K LL+
Sbjct: 175 RQDGTAPLWIASQMGHSEVVRVMLL-RGADRDAARNDGTTALLKAANKGYNDVIKELLKF 233
Query: 1052 GANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
+ G +HAA + + V L L+
Sbjct: 234 SPTLGILKN-GTSALHAAVLSGNIKTVALLLE 264
Score = 73.3 bits (172), Expect = 8e-12
Identities = 43/160 (26%), Positives = 81/160 (50%), Gaps = 2/160 (1%)
Query: 70 AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNG 129
A GN ++++ LL++ + + G T L +AA +D R LV GA ++
Sbjct: 19 AARRGNLALLKLLLNSGRVD-VDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRE 77
Query: 130 AGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKA 189
+G T L AA +G +V++ +G A+ ++ T + A++ GH ++E L K A
Sbjct: 78 SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDEGTALLAASQYGHMQVVETLL-KHGA 136
Query: 190 SIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+I ++ DG+T + +A+ G+ D +L G ++ P +
Sbjct: 137 NIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQ 176
Score = 69.7 bits (163), Expect = 1e-10
Identities = 80/295 (27%), Positives = 134/295 (45%), Gaps = 34/295 (11%)
Query: 771 AAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDH 830
AA+ GNLA L LLL G + V D G T L +A + D VR L+
Sbjct: 19 AARRGNLALLKLLLNSG-----RVDVDCRDS-HGTTLLMVAAYAGHIDCVRELV------ 66
Query: 831 KGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNH 890
+ A I+ E G +AL +A + VV+ L GA +T+ +
Sbjct: 67 ----LQGADINLQRESGTTALFFAAQ---------QGHNDVVRFLFGFGASTEFRTK-DE 112
Query: 891 ETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLT 950
TA + G+ V+ ++ H + ++ Q G T L +A G++ ++ LL
Sbjct: 113 GTALLAASQYGHMQVVETLLKHGAN------IHDQLYDGATALFLAAQGGYLDVIRLLLA 166
Query: 951 NHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHL 1010
+ A+V+ +G + L +A++ G+ +V +L A ++ +G TAL AA GY +
Sbjct: 167 SGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDV 226
Query: 1011 VKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKP 1065
+K L++ + + +L + LH A SG I+ LLLE GA+ ++ + P
Sbjct: 227 IKELLK-FSPTLGILK-NGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELP 279
Score = 63.7 bits (148), Expect = 7e-09
Identities = 66/227 (29%), Positives = 105/227 (46%), Gaps = 29/227 (12%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA+ GH ++ L G S + T D TAL A + VVETLL +GA++
Sbjct: 79 GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDEGTALLAASQYGHMQVVETLLKHGANI 138
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
H + T L +AA+ D L LL SGA N+ +DG P+ +A++ G+ + +
Sbjct: 139 HDQ-LYDGATALFLAAQGGYLDVIRL-LLASGAKVNQPRQDGTAPLWIASQMGHSEVVRV 196
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
+L G D G T L A D+++ L++F S + +
Sbjct: 197 MLLRGADRDAARN-------DGTTALLKAANKGYNDVIKELLKF-------SPTLGIL-- 240
Query: 843 VDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHN 889
++G SALH A + + + + V L+E GAD SL+ + N
Sbjct: 241 --KNGTSALHAA---------VLSGNIKTVALLLEAGADPSLRNKAN 276
Score = 57.6 bits (133), Expect = 4e-07
Identities = 51/165 (30%), Positives = 81/165 (49%), Gaps = 8/165 (4%)
Query: 67 LLLAVEAGNQSMVRELLS--AQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVV 124
LL A + G+ +V LL A +QL G TAL LAA+ +D+ R+L+ GA V
Sbjct: 116 LLAASQYGHMQVVETLLKHGANIHDQLYD----GATALFLAAQGGYLDVIRLLLASGAKV 171
Query: 125 DATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
+ G PL IA+ G +V+ A+ A N+ T + AA G+ +I+ L
Sbjct: 172 NQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELL 231
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
KF ++ K+G++ +H A L+G+ +L + G + NK
Sbjct: 232 -KFSPTL-GILKNGTSALHAAVLSGNIKTVALLLEAGADPSLRNK 274
Score = 55.2 bits (127), Expect = 2e-06
Identities = 38/129 (29%), Positives = 66/129 (51%), Gaps = 2/129 (1%)
Query: 647 RMIFWDTFFEKYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVES 706
R +F +++ D ++ A++YGH+ ++ TLL+ G ++ D TAL +A +
Sbjct: 96 RFLFGFGASTEFRTKDEGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQG 155
Query: 707 CKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMT 766
V+ LL GA V+ + + PL IA+++ + +MLL+ GA + A DG T
Sbjct: 156 GYLDVIRLLLASGAKVN-QPRQDGTAPLWIASQMGHSEVVRVMLLR-GADRDAARNDGTT 213
Query: 767 PVHVAAKFG 775
+ AA G
Sbjct: 214 ALLKAANKG 222
Score = 51.2 bits (117), Expect = 4e-05
Identities = 39/125 (31%), Positives = 56/125 (44%), Gaps = 2/125 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G + AA GH+ + L+ +G +++ TAL A + VV L G+GA
Sbjct: 46 GTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGAST 105
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
R K T L +AA + LLK GA + DG T + +AA+ G L + L
Sbjct: 106 EFR-TKDEGTAL-LAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRL 163
Query: 783 LLEDG 787
LL G
Sbjct: 164 LLASG 168
Score = 43.6 bits (98), Expect = 0.008
Identities = 33/104 (31%), Positives = 49/104 (47%), Gaps = 6/104 (5%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DG + A++ GH ++ +L +G D ND TAL A V++ LL +
Sbjct: 177 DGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPT 236
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP---NKATE 762
+ I K + LH AA + K +LL++GA P NKA E
Sbjct: 237 LGIL--KNGTSALH-AAVLSGNIKTVALLLEAGADPSLRNKANE 277
Score = 42.3 bits (95), Expect = 0.018
Identities = 38/165 (23%), Positives = 71/165 (43%), Gaps = 5/165 (3%)
Query: 57 DLVFQR--GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMA 114
D+ QR G L A + G+ +VR L + + + T TAL A++ + +
Sbjct: 71 DINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFR--TKDEGTALLAASQYGHMQVV 128
Query: 115 RILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAEN 174
L+ +GA + G T L +AA G +++ A + P+ +A++
Sbjct: 129 ETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQM 188
Query: 175 GHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
GH+ ++ ++ + A DG+T + A+ G+ D L K
Sbjct: 189 GHSEVVRVMLLR-GADRDAARNDGTTALLKAANKGYNDVIKELLK 232
>AJ251238-1|CAC17765.1| 587|Homo sapiens hypothetical protein
protein.
Length = 587
Score = 104 bits (249), Expect = 4e-21
Identities = 83/309 (26%), Positives = 142/309 (45%), Gaps = 20/309 (6%)
Query: 1032 PLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
PL A G E K +++ G N+ ++ G P+H AA +++ + +P +
Sbjct: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
T T ++A +G + + L++ IS +++ TPL A E +A+ V++L
Sbjct: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSR---ETPLYKACERKNAEAVKIL 176
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQA 1211
V+ A G TA+H + V+ ++ S S G+TPL +AA GQ
Sbjct: 177 VQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQL 236
Query: 1212 ETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQA 1271
E +R L+ + ++A S L+ A N +E VV LL S G A
Sbjct: 237 EALR-FLAKYGADINTQASDNAS------------ALYEACKNEHEEVVEFLL-SQGADA 282
Query: 1272 DAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEV 1331
+ +N++G PLH+A G+ IV +LL ++ R G + LH+A+ H +++E
Sbjct: 283 N-KTNKDGLLPLHIASKKGNYRIVQMLLPVTSRT--RIRRSGVSPLHLAAERNHDEVLEA 339
Query: 1332 LLGQGAEIN 1340
LL ++N
Sbjct: 340 LLSARFDVN 348
Score = 95.5 bits (227), Expect = 2e-18
Identities = 77/297 (25%), Positives = 138/297 (46%), Gaps = 17/297 (5%)
Query: 1172 AAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT 1231
A + G L M K G PLH AAYYGQ ++ L PGT+
Sbjct: 64 AIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRT-- 121
Query: 1232 GVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGH 1291
L E T ++LA G+ + + LL AG + D SN++ PL+ AC +
Sbjct: 122 -------LQEE---TAVYLATCRGHLDCLLSLLQ-AGAEPDI-SNKSRETPLYKACERKN 169
Query: 1292 MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLH 1351
V +L+ +A+ H +R G T LH + + +++++L+ GA++ + + G TPL
Sbjct: 170 AEAVKILVQHNADTNHRCNR-GWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLF 228
Query: 1352 CAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDD 1411
AA++G L ++ L + GA ++ + N + ++ A H +V+E+LL + D +
Sbjct: 229 VAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANK--TN 286
Query: 1412 KRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKERAKDLIAA 1468
K + L + SK N ++ + V+ + +S +++ E + L++A
Sbjct: 287 KDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSA 343
Score = 95.5 bits (227), Expect = 2e-18
Identities = 80/280 (28%), Positives = 128/280 (45%), Gaps = 18/280 (6%)
Query: 1135 PLQLAAEGGHADVVRVLVRAGASCTDENRAGL-TAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
PL AA G ++VL RA D+ TAV+LA GH + L +
Sbjct: 93 PLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDI 152
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAY 1253
S K TPL+ A AE V+ L+ H T G T LH +
Sbjct: 153 SNKSRETPLYKACERKNAEAVKILVQHNADTNHR-------------CNRGWTALHESVS 199
Query: 1254 NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHG 1313
+ V+++L+ S G + ++ N G PL +A G + + L A++ ++
Sbjct: 200 RNDLEVMQILV-SGGAKVES-KNAYGITPLFVAAQSGQLEALRFLAKYGADI-NTQASDN 256
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPK 1373
+ L+ A + H ++VE LL QGA+ N T+K+G PLH A+K G+ +V++L + +
Sbjct: 257 ASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTR 316
Query: 1374 SETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKR 1413
+ +P+ AA NH++VLE LL D + + +R
Sbjct: 317 IRRS-GVSPLHLAAERNHDEVLEALLSARFDVNTPLAPER 355
Score = 93.9 bits (223), Expect = 6e-18
Identities = 76/294 (25%), Positives = 137/294 (46%), Gaps = 18/294 (6%)
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMI-AHISTADVSRAL 922
I D + +K +I+ G +++ + H A G + + A+ T D R L
Sbjct: 65 IKDGDEEALKTMIKEGKNLAEPNKEGW-LPLHEAAYYGQVGCLKVLQRAYPGTID-QRTL 122
Query: 923 NRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALL 982
+ ++ L C RGH+ + +LL A D+ + + L+ A E + L+
Sbjct: 123 QEETAV----YLATC-RGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILV 177
Query: 983 TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQI 1042
+ A N + G TALH + +++ L+ A ++ TPL +AA SGQ+
Sbjct: 178 QHNADTNHRCNRGWTALHESVSRNDLEVMQILVSG-GAKVESKNAYGITPLFVAAQSGQL 236
Query: 1043 EVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHI 1102
E + L + GA+I+ ++ A +N + EVV+ L Q + T KDG HI
Sbjct: 237 EALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGAD-ANKTNKDGLLPLHI 295
Query: 1103 AAIQGSVKVIEELMKFDRTGVISARNKLNDS--TPLQLAAEGGHADVVRVLVRA 1154
A+ +G+ ++++ L+ +++R ++ S +PL LAAE H +V+ L+ A
Sbjct: 296 ASKKGNYRIVQMLLP------VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSA 343
Score = 77.8 bits (183), Expect = 4e-13
Identities = 102/405 (25%), Positives = 174/405 (42%), Gaps = 52/405 (12%)
Query: 662 DGARSIHTAARYGHVGIINTLLQK-GESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
+G +H AA YG VG + L + ++D T TA+++A + +LL GA
Sbjct: 89 EGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGA 148
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
+ I K RETPL+ A + + +L++ A N G T +H + +L +
Sbjct: 149 EPDI-SNKSRETPLYKACERKNAE-AVKILVQHNADTNHRCNRGWTALHESVSRNDLEVM 206
Query: 781 VLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFI 840
+L+ G K G TPL +A +S + +R L ++ D I
Sbjct: 207 QILVSGGAKVESKN-------AYGITPLFVAAQSGQLEALRFLAKYGAD----------I 249
Query: 841 DAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIA 900
+ D ASAL+ ACK EE VV+ L+ GAD + +T + H +
Sbjct: 250 NTQASDNASALYEACKNEHEE---------VVEFLLSQGADAN-KTNKDGLLPLHIASKK 299
Query: 901 GNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH-------- 952
GN ++ ++ S + R+ G +PL +A R H +++ LL+
Sbjct: 300 GNYRIVQMLLPVTSRTRIRRS-------GVSPLHLAAERNHDEVLEALLSARFDVNTPLA 352
Query: 953 -ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLV 1011
R +++ SAL+ A + + + LL + A N R+ + L +A +G +
Sbjct: 353 PERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTM 409
Query: 1012 KFLIRDHNAMID--VLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
+ L+ DH A ID + T P + A + + K L++LG +
Sbjct: 410 QLLL-DHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCD 453
Score = 73.7 bits (173), Expect = 6e-12
Identities = 106/410 (25%), Positives = 182/410 (44%), Gaps = 51/410 (12%)
Query: 676 VGIINTLLQKGESVDVTTNDNYTA--LHIAVESCKPAVVETLLGYGADVHIRGGKQRETP 733
+G+ ++QK S T+ A L A++ ++T++ G ++ K+ P
Sbjct: 35 MGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNL-AEPNKEGWLP 93
Query: 734 LHIAARIPDGDKCALMLLKSGAGP-NKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLR 792
LH AA C +L ++ G ++ T T V++A G+L L+ LL+ G +P
Sbjct: 94 LHEAAYYGQVG-CLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDI 152
Query: 793 KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKD--HKGESVSTAFIDAVDEDGASA 850
K + ETPL AC + V+ L++ D H+ TA ++V +
Sbjct: 153 SNK-------SRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEV 205
Query: 851 LHY------------ACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
+ A +T V + + ++ L + GAD++ Q N + C
Sbjct: 206 MQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACK 265
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVF 958
++ + E + AD N+ N G PL IA +G+ ++V LL +R +
Sbjct: 266 --NEHEEVVEFLLS-QGADA----NKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR 318
Query: 959 DVEGRSALHLAAEHGYLQVCDALLTNKAFINS-----KAR----NGRTALHLAAMNGYAH 1009
G S LHLAAE + +V +ALL+ + +N+ +AR +AL+ A +N +
Sbjct: 319 R-SGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVY 377
Query: 1010 LVKFLIRDHNA--MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDA 1057
+ L++ H A DV+ +PL +A G + +LLL+ GANIDA
Sbjct: 378 ATELLLQ-HGADPNRDVI-----SPLLVAIRHGCLRTMQLLLDHGANIDA 421
Score = 70.1 bits (164), Expect = 8e-11
Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 7/163 (4%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D+ + + PL A E N V+ L+ + G TALH + R D+++ +I
Sbjct: 151 DISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNR--GWTALHESVSRNDLEVMQI 208
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYF--YGVRANAAIADNEDRTPMHLAAEN 174
LV GA V++ N G TPL +AA G +++ YG N +DN + ++ A +N
Sbjct: 209 LVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDN--ASALYEACKN 266
Query: 175 GHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
H ++E L + A + KDG +HIAS G+ ML
Sbjct: 267 EHEEVVEFLLSQ-GADANKTNKDGLLPLHIASKKGNYRIVQML 308
Score = 56.8 bits (131), Expect = 8e-07
Identities = 37/126 (29%), Positives = 62/126 (49%), Gaps = 4/126 (3%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL +A ++G +R L A+ + +AL+ A + ++ L+ GA
Sbjct: 223 GITPLFVAAQSGQLEALRFL--AKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGA 280
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE- 181
+ TN G PLHIA+ +G+ +V+ V + I +P+HLAAE H ++E
Sbjct: 281 DANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR-RSGVSPLHLAAERNHDEVLEA 339
Query: 182 LLADKF 187
LL+ +F
Sbjct: 340 LLSARF 345
Score = 53.6 bits (123), Expect = 7e-06
Identities = 40/145 (27%), Positives = 70/145 (48%), Gaps = 6/145 (4%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ G + AA+ G + + L + G ++ +DN +AL+ A ++ VVE LL
Sbjct: 219 KNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQ 278
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
GAD + + K PLHIA++ G+ + +L + G++P+H+AA+ +
Sbjct: 279 GADAN-KTNKDGLLPLHIASK--KGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDE 335
Query: 779 TLVLLLE---DGGDPLRKTKVCIYD 800
L LL D PL + +Y+
Sbjct: 336 VLEALLSARFDVNTPLAPERARLYE 360
Score = 52.8 bits (121), Expect = 1e-05
Identities = 29/96 (30%), Positives = 46/96 (47%)
Query: 134 PLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFE 193
PL A +GDE +K N A + E P+H AA G +++L + +I +
Sbjct: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
Query: 194 RTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
RT T +++A+ GH DC + L + G + NK
Sbjct: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNK 155
Score = 43.2 bits (97), Expect = 0.010
Identities = 38/161 (23%), Positives = 67/161 (41%), Gaps = 2/161 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G +PL A G ++ L A + T +TA++LA R +D L+
Sbjct: 88 KEGWLPLHEAAYYGQVGCLKVLQRAYPGT-IDQRTLQEETAVYLATCRGHLDCLLSLLQA 146
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA D +N + +TPL+ A + VK A+ N T +H + ++
Sbjct: 147 GAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVM 206
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
++L A + + G T + +A+ +G + L K G
Sbjct: 207 QILVSG-GAKVESKNAYGITPLFVAAQSGQLEALRFLAKYG 246
Score = 35.5 bits (78), Expect = 2.1
Identities = 25/105 (23%), Positives = 45/105 (42%), Gaps = 1/105 (0%)
Query: 1296 GLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAK 1355
G++ S+ L ++ L A G + ++ ++ +G + +K GW PLH AA
Sbjct: 40 GVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAY 99
Query: 1356 AGHLNVVKLLCESGASPKSETNL-NCAPIWFAASENHNDVLEYLL 1399
G + +K+L + + L ++ A H D L LL
Sbjct: 100 YGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLL 144
>AB056723-1|BAB64532.1| 587|Homo sapiens ankyrin repeat-conteining
protein with a SOCS box-2 protein.
Length = 587
Score = 104 bits (249), Expect = 4e-21
Identities = 83/309 (26%), Positives = 142/309 (45%), Gaps = 20/309 (6%)
Query: 1032 PLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
PL A G E K +++ G N+ ++ G P+H AA +++ + +P +
Sbjct: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
T T ++A +G + + L++ IS +++ TPL A E +A+ V++L
Sbjct: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSR---ETPLYKACERKNAEAVKIL 176
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQA 1211
V+ A G TA+H + V+ ++ S S G+TPL +AA GQ
Sbjct: 177 VQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQL 236
Query: 1212 ETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQA 1271
E +R L+ + ++A S L+ A N +E VV LL S G A
Sbjct: 237 EALR-FLAKYGADINTQASDNAS------------ALYEACKNEHEEVVEFLL-SQGADA 282
Query: 1272 DAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEV 1331
+ +N++G PLH+A G+ IV +LL ++ R G + LH+A+ H +++E
Sbjct: 283 N-KTNKDGLLPLHIASKKGNYRIVQMLLPVTSRT--RIRRSGVSPLHLAAERNHDEVLEA 339
Query: 1332 LLGQGAEIN 1340
LL ++N
Sbjct: 340 LLSARFDVN 348
Score = 95.5 bits (227), Expect = 2e-18
Identities = 77/297 (25%), Positives = 138/297 (46%), Gaps = 17/297 (5%)
Query: 1172 AAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT 1231
A + G L M K G PLH AAYYGQ ++ L PGT+
Sbjct: 64 AIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRT-- 121
Query: 1232 GVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGH 1291
L E T ++LA G+ + + LL AG + D SN++ PL+ AC +
Sbjct: 122 -------LQEE---TAVYLATCRGHLDCLLSLLQ-AGAEPDI-SNKSRETPLYKACERKN 169
Query: 1292 MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLH 1351
V +L+ +A+ H +R G T LH + + +++++L+ GA++ + + G TPL
Sbjct: 170 AEAVKILVQHNADTNHRCNR-GWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLF 228
Query: 1352 CAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDD 1411
AA++G L ++ L + GA ++ + N + ++ A H +V+E+LL + D +
Sbjct: 229 VAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANK--TN 286
Query: 1412 KRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLSTKEKERAKDLIAA 1468
K + L + SK N ++ + V+ + +S +++ E + L++A
Sbjct: 287 KDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSA 343
Score = 95.5 bits (227), Expect = 2e-18
Identities = 80/280 (28%), Positives = 128/280 (45%), Gaps = 18/280 (6%)
Query: 1135 PLQLAAEGGHADVVRVLVRAGASCTDENRAGL-TAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
PL AA G ++VL RA D+ TAV+LA GH + L +
Sbjct: 93 PLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDI 152
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAY 1253
S K TPL+ A AE V+ L+ H T G T LH +
Sbjct: 153 SNKSRETPLYKACERKNAEAVKILVQHNADTNHR-------------CNRGWTALHESVS 199
Query: 1254 NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHG 1313
+ V+++L+ S G + ++ N G PL +A G + + L A++ ++
Sbjct: 200 RNDLEVMQILV-SGGAKVES-KNAYGITPLFVAAQSGQLEALRFLAKYGADI-NTQASDN 256
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPK 1373
+ L+ A + H ++VE LL QGA+ N T+K+G PLH A+K G+ +V++L + +
Sbjct: 257 ASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTR 316
Query: 1374 SETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKR 1413
+ +P+ AA NH++VLE LL D + + +R
Sbjct: 317 IRRS-GVSPLHLAAERNHDEVLEALLSARFDVNTPLAPER 355
Score = 93.9 bits (223), Expect = 6e-18
Identities = 76/294 (25%), Positives = 137/294 (46%), Gaps = 18/294 (6%)
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMI-AHISTADVSRAL 922
I D + +K +I+ G +++ + H A G + + A+ T D R L
Sbjct: 65 IKDGDEEALKTMIKEGKNLAEPNKEGW-LPLHEAAYYGQVGCLKVLQRAYPGTID-QRTL 122
Query: 923 NRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALL 982
+ ++ L C RGH+ + +LL A D+ + + L+ A E + L+
Sbjct: 123 QEETAV----YLATC-RGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILV 177
Query: 983 TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQI 1042
+ A N + G TALH + +++ L+ A ++ TPL +AA SGQ+
Sbjct: 178 QHNADTNHRCNRGWTALHESVSRNDLEVMQILVSG-GAKVESKNAYGITPLFVAAQSGQL 236
Query: 1043 EVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHI 1102
E + L + GA+I+ ++ A +N + EVV+ L Q + T KDG HI
Sbjct: 237 EALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGAD-ANKTNKDGLLPLHI 295
Query: 1103 AAIQGSVKVIEELMKFDRTGVISARNKLNDS--TPLQLAAEGGHADVVRVLVRA 1154
A+ +G+ ++++ L+ +++R ++ S +PL LAAE H +V+ L+ A
Sbjct: 296 ASKKGNYRIVQMLLP------VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSA 343
Score = 77.8 bits (183), Expect = 4e-13
Identities = 102/405 (25%), Positives = 174/405 (42%), Gaps = 52/405 (12%)
Query: 662 DGARSIHTAARYGHVGIINTLLQK-GESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
+G +H AA YG VG + L + ++D T TA+++A + +LL GA
Sbjct: 89 EGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGA 148
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
+ I K RETPL+ A + + +L++ A N G T +H + +L +
Sbjct: 149 EPDI-SNKSRETPLYKACERKNAE-AVKILVQHNADTNHRCNRGWTALHESVSRNDLEVM 206
Query: 781 VLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFI 840
+L+ G K G TPL +A +S + +R L ++ D I
Sbjct: 207 QILVSGGAKVESKN-------AYGITPLFVAAQSGQLEALRFLAKYGAD----------I 249
Query: 841 DAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIA 900
+ D ASAL+ ACK EE VV+ L+ GAD + +T + H +
Sbjct: 250 NTQASDNASALYEACKNEHEE---------VVEFLLSQGADAN-KTNKDGLLPLHIASKK 299
Query: 901 GNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH-------- 952
GN ++ ++ S + R+ G +PL +A R H +++ LL+
Sbjct: 300 GNYRIVQMLLPVTSRTRIRRS-------GVSPLHLAAERNHDEVLEALLSARFDVNTPLA 352
Query: 953 -ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLV 1011
R +++ SAL+ A + + + LL + A N R+ + L +A +G +
Sbjct: 353 PERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTM 409
Query: 1012 KFLIRDHNAMID--VLTLKKQTPLHLAAASGQIEVCKLLLELGAN 1054
+ L+ DH A ID + T P + A + + K L++LG +
Sbjct: 410 QLLL-DHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCD 453
Score = 73.7 bits (173), Expect = 6e-12
Identities = 106/410 (25%), Positives = 182/410 (44%), Gaps = 51/410 (12%)
Query: 676 VGIINTLLQKGESVDVTTNDNYTA--LHIAVESCKPAVVETLLGYGADVHIRGGKQRETP 733
+G+ ++QK S T+ A L A++ ++T++ G ++ K+ P
Sbjct: 35 MGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNL-AEPNKEGWLP 93
Query: 734 LHIAARIPDGDKCALMLLKSGAGP-NKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLR 792
LH AA C +L ++ G ++ T T V++A G+L L+ LL+ G +P
Sbjct: 94 LHEAAYYGQVG-CLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDI 152
Query: 793 KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKD--HKGESVSTAFIDAVDEDGASA 850
K + ETPL AC + V+ L++ D H+ TA ++V +
Sbjct: 153 SNK-------SRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEV 205
Query: 851 LHY------------ACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
+ A +T V + + ++ L + GAD++ Q N + C
Sbjct: 206 MQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACK 265
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVF 958
++ + E + AD N+ N G PL IA +G+ ++V LL +R +
Sbjct: 266 --NEHEEVVEFLLS-QGADA----NKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR 318
Query: 959 DVEGRSALHLAAEHGYLQVCDALLTNKAFINS-----KAR----NGRTALHLAAMNGYAH 1009
G S LHLAAE + +V +ALL+ + +N+ +AR +AL+ A +N +
Sbjct: 319 R-SGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVY 377
Query: 1010 LVKFLIRDHNA--MIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDA 1057
+ L++ H A DV+ +PL +A G + +LLL+ GANIDA
Sbjct: 378 ATELLLQ-HGADPNRDVI-----SPLLVAIRHGCLRTMQLLLDHGANIDA 421
Score = 70.1 bits (164), Expect = 8e-11
Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 7/163 (4%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D+ + + PL A E N V+ L+ + G TALH + R D+++ +I
Sbjct: 151 DISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNR--GWTALHESVSRNDLEVMQI 208
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYF--YGVRANAAIADNEDRTPMHLAAEN 174
LV GA V++ N G TPL +AA G +++ YG N +DN + ++ A +N
Sbjct: 209 LVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDN--ASALYEACKN 266
Query: 175 GHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
H ++E L + A + KDG +HIAS G+ ML
Sbjct: 267 EHEEVVEFLLSQ-GADANKTNKDGLLPLHIASKKGNYRIVQML 308
Score = 56.8 bits (131), Expect = 8e-07
Identities = 37/126 (29%), Positives = 62/126 (49%), Gaps = 4/126 (3%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G PL +A ++G +R L A+ + +AL+ A + ++ L+ GA
Sbjct: 223 GITPLFVAAQSGQLEALRFL--AKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGA 280
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE- 181
+ TN G PLHIA+ +G+ +V+ V + I +P+HLAAE H ++E
Sbjct: 281 DANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR-RSGVSPLHLAAERNHDEVLEA 339
Query: 182 LLADKF 187
LL+ +F
Sbjct: 340 LLSARF 345
Score = 53.6 bits (123), Expect = 7e-06
Identities = 40/145 (27%), Positives = 70/145 (48%), Gaps = 6/145 (4%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ G + AA+ G + + L + G ++ +DN +AL+ A ++ VVE LL
Sbjct: 219 KNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQ 278
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
GAD + + K PLHIA++ G+ + +L + G++P+H+AA+ +
Sbjct: 279 GADAN-KTNKDGLLPLHIASK--KGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDE 335
Query: 779 TLVLLLE---DGGDPLRKTKVCIYD 800
L LL D PL + +Y+
Sbjct: 336 VLEALLSARFDVNTPLAPERARLYE 360
Score = 52.8 bits (121), Expect = 1e-05
Identities = 29/96 (30%), Positives = 46/96 (47%)
Query: 134 PLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFE 193
PL A +GDE +K N A + E P+H AA G +++L + +I +
Sbjct: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
Query: 194 RTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
RT T +++A+ GH DC + L + G + NK
Sbjct: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNK 155
Score = 43.2 bits (97), Expect = 0.010
Identities = 38/161 (23%), Positives = 67/161 (41%), Gaps = 2/161 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G +PL A G ++ L A + T +TA++LA R +D L+
Sbjct: 88 KEGWLPLHEAAYYGQVGCLKVLQRAYPGT-IDQRTLQEETAVYLATCRGHLDCLLSLLQA 146
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA D +N + +TPL+ A + VK A+ N T +H + ++
Sbjct: 147 GAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVM 206
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
++L A + + G T + +A+ +G + L K G
Sbjct: 207 QILVSG-GAKVESKNAYGITPLFVAAQSGQLEALRFLAKYG 246
Score = 35.5 bits (78), Expect = 2.1
Identities = 25/105 (23%), Positives = 45/105 (42%), Gaps = 1/105 (0%)
Query: 1296 GLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAK 1355
G++ S+ L ++ L A G + ++ ++ +G + +K GW PLH AA
Sbjct: 40 GVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAY 99
Query: 1356 AGHLNVVKLLCESGASPKSETNL-NCAPIWFAASENHNDVLEYLL 1399
G + +K+L + + L ++ A H D L LL
Sbjct: 100 YGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLL 144
>BC101276-1|AAI01277.1| 420|Homo sapiens ANKDD1A protein protein.
Length = 420
Score = 103 bits (248), Expect = 5e-21
Identities = 72/257 (28%), Positives = 131/257 (50%), Gaps = 13/257 (5%)
Query: 933 LLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTN--KAFINS 990
LL++ GH++++ L+ + A++ +G + LH AA+ G++ V ++ + ++
Sbjct: 1 LLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDH 60
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIR---DHNAMIDVLTLKKQTPLHLAAASGQIEVCKL 1047
+ GRTA H AA +G + FL+ DHN V + T LHLAA G + V +
Sbjct: 61 VDKLGRTAFHRAAEHGQLDALDFLVGSGCDHN----VKDKEGNTALHLAAGRGHMAVLQR 116
Query: 1048 LLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQG 1107
L+++G +++ + G +H+AA ++ + VQL L+ + V A T+ +C H AA+ G
Sbjct: 117 LVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRA-GSTVNALTQKNLSCLHYAALSG 175
Query: 1108 SVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLT 1167
S V L+ G + ++PL LA +VR+L+ + + + T
Sbjct: 176 SEDVSRVLI---HAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQT 232
Query: 1168 AVHLAAEHGHTNVLDVM 1184
+HLAAEH ++ D++
Sbjct: 233 PLHLAAEHAWQDIADML 249
Score = 102 bits (245), Expect = 1e-20
Identities = 88/303 (29%), Positives = 141/303 (46%), Gaps = 22/303 (7%)
Query: 1033 LHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA- 1091
L L+A G + + ++L+ GA I + G +H AAQ + V+ ++ ++ +
Sbjct: 1 LLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDH 60
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
K G T H AA G + ++ L+ +G +T L LAA GH V++ L
Sbjct: 61 VDKLGRTAFHRAAEHGQLDALDFLVG---SGCDHNVKDKEGNTALHLAAGRGHMAVLQRL 117
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLD-VMRSTNTLRISSKKLGLTPLHIAAYYGQ 1210
V G ++N GLTA+H AA H + + ++R+ +T+ ++K L+ LH AA G
Sbjct: 118 VDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQK-NLSCLHYAALSG- 175
Query: 1211 AETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQ 1270
+E V +L H G + G +PLHLA + +VRLL+NS
Sbjct: 176 SEDVSRVLIHAGGCAN------------VVDHQGASPLHLAVRHNFPALVRLLINSDS-D 222
Query: 1271 ADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVE 1330
+A N PLHLA I +LL + L+ D GKT L +A H +V+
Sbjct: 223 VNAVDNRQ-QTPLHLAAEHAWQDIADMLLIAGVD-LNLRDEQGKTALAVAVRSNHVSLVD 280
Query: 1331 VLL 1333
+++
Sbjct: 281 MII 283
Score = 99 bits (238), Expect = 8e-20
Identities = 82/267 (30%), Positives = 125/267 (46%), Gaps = 20/267 (7%)
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLD-VMRSTNTLRISS 1194
L L+A GH ++++LV +GA E++ GLT +H AA+ GH VL +M + +
Sbjct: 1 LLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDH 60
Query: 1195 -KKLGLTPLHIAAYYGQAETVRELL-SHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
KLG T H AA +GQ + + L+ S VK + G T LHLAA
Sbjct: 61 VDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDK--------------EGNTALHLAA 106
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
G+ V++ L++ G+ + N G LH A G H V LLL R+ +++ +
Sbjct: 107 GRGHMAVLQRLVD-IGLDLEE-QNAEGLTALHSAAGGSHPDCVQLLL-RAGSTVNALTQK 163
Query: 1313 GKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASP 1372
+ LH A+ G + VL+ G N D G +PLH A + +V+LL S +
Sbjct: 164 NLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDV 223
Query: 1373 KSETNLNCAPIWFAASENHNDVLEYLL 1399
+ N P+ AA D+ + LL
Sbjct: 224 NAVDNRQQTPLHLAAEHAWQDIADMLL 250
Score = 99.5 bits (237), Expect = 1e-19
Identities = 75/285 (26%), Positives = 135/285 (47%), Gaps = 10/285 (3%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
++++ L+ +GA + +++ T H A G+ V+ ++ + DV AL+ + +G
Sbjct: 11 RILQILVNSGAKIHCESKDGL-TLLHCAAQKGHVPVLAFIMEDLE--DV--ALDHVDKLG 65
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
T A G + ++ L+ + +V D EG +ALHLAA G++ V L+ +
Sbjct: 66 RTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLE 125
Query: 990 SKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL 1049
+ G TALH AA + V+ L+R + ++ LT K + LH AA SG +V ++L+
Sbjct: 126 EQNAEGLTALHSAAGGSHPDCVQLLLRA-GSTVNALTQKNLSCLHYAALSGSEDVSRVLI 184
Query: 1050 ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSV 1109
G + D G P+H A ++N+ +V+L + + V A T H+AA
Sbjct: 185 HAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSD-VNAVDNRQQTPLHLAAEHAWQ 243
Query: 1110 KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRA 1154
+ + L+ GV T L +A H +V ++++A
Sbjct: 244 DIADMLL---IAGVDLNLRDEQGKTALAVAVRSNHVSLVDMIIKA 285
Score = 91.1 bits (216), Expect = 4e-17
Identities = 68/254 (26%), Positives = 123/254 (48%), Gaps = 5/254 (1%)
Query: 966 LHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRD-HNAMIDV 1024
L L+A G+L++ L+ + A I+ ++++G T LH AA G+ ++ F++ D + +D
Sbjct: 1 LLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDH 60
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
+ +T H AA GQ++ L+ G + + D+ G +H AA + V+Q +
Sbjct: 61 VDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDI 120
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
+L +G T H AA ++ L++ T ++A + N S L AA G
Sbjct: 121 GLDL-EEQNAEGLTALHSAAGGSHPDCVQLLLRAGST--VNALTQKNLSC-LHYAALSGS 176
Query: 1145 ADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHI 1204
DV RVL+ AG + G + +HLA H ++ ++ ++++ + TPLH+
Sbjct: 177 EDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHL 236
Query: 1205 AAYYGQAETVRELL 1218
AA + + LL
Sbjct: 237 AAEHAWQDIADMLL 250
Score = 74.9 bits (176), Expect = 3e-12
Identities = 59/238 (24%), Positives = 103/238 (43%), Gaps = 14/238 (5%)
Query: 1171 LAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAP 1230
L+A GH +L ++ ++ K GLT LH AA G + ++ +
Sbjct: 3 LSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVD 62
Query: 1231 TGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGG 1290
+ G T H AA +G + + L+ S G + E G LHLA G
Sbjct: 63 -----------KLGRTAFHRAAEHGQLDALDFLVGS-GCDHNVKDKE-GNTALHLAAGRG 109
Query: 1291 HMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPL 1350
HM+++ L+ +L + G T LH A+ H V++LL G+ +NA + + L
Sbjct: 110 HMAVLQRLVDIGLDL-EEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCL 168
Query: 1351 HCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
H AA +G +V ++L +G + +P+ A N ++ L++ + D ++
Sbjct: 169 HYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAV 226
Score = 72.9 bits (171), Expect = 1e-11
Identities = 79/307 (25%), Positives = 135/307 (43%), Gaps = 35/307 (11%)
Query: 711 VVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLK-SGAGPNKATEDGMTPVH 769
+++ L+ GA +H K T LH AA+ A ++ + + G T H
Sbjct: 12 ILQILVNSGAKIHCES-KDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFH 70
Query: 770 VAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKD 829
AA+ G L L L+ G D K K G T L +A +++ L++ D
Sbjct: 71 RAAEHGQLDALDFLVGSGCDHNVKDK-------EGNTALHLAAGRGHMAVLQRLVDIGLD 123
Query: 830 HKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHN 889
++ + +G +ALH A + + V+ L+ G+ V+ T+ N
Sbjct: 124 ----------LEEQNAEGLTALHSAAGGSHPDC---------VQLLLRAGSTVNALTQKN 164
Query: 890 HETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLL 949
+ HY A++G+ DV +I A+V ++ Q G +PL +A LV L+
Sbjct: 165 L-SCLHYAALSGSEDVSRVLIHAGGCANV---VDHQ---GASPLHLAVRHNFPALVRLLI 217
Query: 950 TNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAH 1009
+ + V+ D ++ LHLAAEH + + D LL +N + G+TAL +A + +
Sbjct: 218 NSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDEQGKTALAVAVRSNHVS 277
Query: 1010 LVKFLIR 1016
LV +I+
Sbjct: 278 LVDMIIK 284
Score = 69.3 bits (162), Expect = 1e-10
Identities = 46/157 (29%), Positives = 79/157 (50%), Gaps = 5/157 (3%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVD-MARILVDYGAV-V 124
LLL+ G+ +++ L+++ ++ + G T LH AA++ V +A I+ D V +
Sbjct: 1 LLLSAWFGHLRILQILVNS--GAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVAL 58
Query: 125 DATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
D + G+T H AA G + + G + + D E T +HLAA GH A+++ L
Sbjct: 59 DHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLV 118
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
D + E+ +G T +H A+ H DC +L + G
Sbjct: 119 D-IGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAG 154
Score = 67.3 bits (157), Expect = 6e-10
Identities = 79/320 (24%), Positives = 136/320 (42%), Gaps = 37/320 (11%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHI-RGGK 728
+A +GH+ I+ L+ G + + D T LH A + V+ ++ DV + K
Sbjct: 4 SAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDK 63
Query: 729 QRETPLHIAARIPDGDKCAL-MLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
T H AA G AL L+ SG N ++G T +H+AA G++A L L++ G
Sbjct: 64 LGRTAFHRAAE--HGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIG 121
Query: 788 GDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDG 847
D + G T L A PD V+ L+ + + ++A+ +
Sbjct: 122 LDLEEQN-------AEGLTALHSAAGGSHPDCVQLLLR----------AGSTVNALTQKN 164
Query: 848 ASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMT 907
S LHYA E+V + LI G ++ H + H A+ N +
Sbjct: 165 LSCLHYAALSGSEDVS---------RVLIHAGGCANV-VDHQGASPLH-LAVRHNFPALV 213
Query: 908 EMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALH 967
++ + S +DV+ NRQ TPL +A + + LL +++ D +G++AL
Sbjct: 214 RLLIN-SDSDVNAVDNRQQ----TPLHLAAEHAWQDIADMLLIAGVDLNLRDEQGKTALA 268
Query: 968 LAAEHGYLQVCDALLTNKAF 987
+A ++ + D ++ F
Sbjct: 269 VAVRSNHVSLVDMIIKADRF 288
Score = 61.7 bits (143), Expect = 3e-08
Identities = 44/166 (26%), Positives = 77/166 (46%), Gaps = 3/166 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G L LA G+ ++++ L+ L+ G TALH AA D ++L+
Sbjct: 96 KEGNTALHLAAGRGHMAVLQRLVDIGL--DLEEQNAEGLTALHSAAGGSHPDCVQLLLRA 153
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G+ V+A + LH AA G E + + A + D++ +P+HLA + A++
Sbjct: 154 GSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALV 213
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHM 226
LL + + + T +H+A+ + D A ML GV L++
Sbjct: 214 RLLINS-DSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNL 258
Score = 61.3 bits (142), Expect = 4e-08
Identities = 42/157 (26%), Positives = 69/157 (43%), Gaps = 3/157 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + V+ LL A + + A T + LH AA D++R+L+ G
Sbjct: 131 GLTALHSAAGGSHPDCVQLLLRAGST--VNALTQKNLSCLHYAALSGSEDVSRVLIHAGG 188
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ + G +PLH+A LV+ ++ DN +TP+HLAAE+ I ++
Sbjct: 189 CANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADM 248
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
L + R + G T + +A + H M+ K
Sbjct: 249 LLIA-GVDLNLRDEQGKTALAVAVRSNHVSLVDMIIK 284
Score = 60.1 bits (139), Expect = 8e-08
Identities = 56/201 (27%), Positives = 93/201 (46%), Gaps = 21/201 (10%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G + H AA +G + ++ L+ G +V + TALH+A AV++ L+ G D+
Sbjct: 65 GRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDL 124
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + T LH AA D C +LL++G+ N T+ ++ +H AA G+ +
Sbjct: 125 EEQNA-EGLTALHSAAGGSHPD-CVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRV 182
Query: 783 LLEDGGDPLRKTKVCIYDV-VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
L+ GG C V G +PL +A R P +VR LI S + ++
Sbjct: 183 LIHAGG--------CANVVDHQGASPLHLAVRHNFPALVRLLIN----------SDSDVN 224
Query: 842 AVDEDGASALHYACKVTKEEV 862
AVD + LH A + +++
Sbjct: 225 AVDNRQQTPLHLAAEHAWQDI 245
Score = 57.6 bits (133), Expect = 4e-07
Identities = 78/291 (26%), Positives = 126/291 (43%), Gaps = 39/291 (13%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY--TALHIAVESCKPAVVETLLGYG 719
DG +H AA+ GHV ++ +++ E V + D TA H A E + ++ L+G G
Sbjct: 29 DGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSG 88
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALM-LLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
D +++ K+ T LH+AA G L L+ G + +G+T +H AA +
Sbjct: 89 CDHNVK-DKEGNTALHLAA--GRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPD 145
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LLL G T+ + + L A S D+ R LI H G
Sbjct: 146 CVQLLLRAGSTVNALTQKNL-------SCLHYAALSGSEDVSRVLI-----HAG-----G 188
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
+ VD GAS LH A + P +V+ LI + +DV+ + +T H A
Sbjct: 189 CANVVDHQGASPLHLAVR-----HNFPA----LVRLLINSDSDVN-AVDNRQQTPLHLAA 238
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLL 949
D+ ++ I+ D LN ++ G T L +A H+ LV+ ++
Sbjct: 239 EHAWQDIADMLL--IAGVD----LNLRDEQGKTALAVAVRSNHVSLVDMII 283
Score = 55.2 bits (127), Expect = 2e-06
Identities = 36/131 (27%), Positives = 61/131 (46%), Gaps = 2/131 (1%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K +G ++H AA GH+ ++ L+ G ++ + TALH A P V+ LL
Sbjct: 94 KDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRA 153
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
G+ V+ K LH AA + + + +L+ +G N G +P+H+A + A
Sbjct: 154 GSTVNALTQKNLSC-LHYAA-LSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPA 211
Query: 779 TLVLLLEDGGD 789
+ LL+ D
Sbjct: 212 LVRLLINSDSD 222
Score = 48.8 bits (111), Expect = 2e-04
Identities = 34/116 (29%), Positives = 54/116 (46%), Gaps = 3/116 (2%)
Query: 115 RILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI--ADNEDRTPMHLAA 172
+ILV+ GA + + G T LH AA +G P++ + + A+ D RT H AA
Sbjct: 14 QILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAA 73
Query: 173 ENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
E+G ++ L + K+G+T +H+A+ GH L G+ L N
Sbjct: 74 EHGQLDALDFLVGS-GCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQN 128
>BC101274-1|AAI01275.1| 423|Homo sapiens ANKDD1A protein protein.
Length = 423
Score = 103 bits (248), Expect = 5e-21
Identities = 72/257 (28%), Positives = 131/257 (50%), Gaps = 13/257 (5%)
Query: 933 LLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTN--KAFINS 990
LL++ GH++++ L+ + A++ +G + LH AA+ G++ V ++ + ++
Sbjct: 4 LLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDH 63
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIR---DHNAMIDVLTLKKQTPLHLAAASGQIEVCKL 1047
+ GRTA H AA +G + FL+ DHN V + T LHLAA G + V +
Sbjct: 64 VDKLGRTAFHRAAEHGQLDALDFLVGSGCDHN----VKDKEGNTALHLAAGRGHMAVLQR 119
Query: 1048 LLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQG 1107
L+++G +++ + G +H+AA ++ + VQL L+ + V A T+ +C H AA+ G
Sbjct: 120 LVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRA-GSTVNALTQKNLSCLHYAALSG 178
Query: 1108 SVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLT 1167
S V L+ G + ++PL LA +VR+L+ + + + T
Sbjct: 179 SEDVSRVLI---HAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQT 235
Query: 1168 AVHLAAEHGHTNVLDVM 1184
+HLAAEH ++ D++
Sbjct: 236 PLHLAAEHAWQDIADML 252
Score = 102 bits (245), Expect = 1e-20
Identities = 88/303 (29%), Positives = 141/303 (46%), Gaps = 22/303 (7%)
Query: 1033 LHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA- 1091
L L+A G + + ++L+ GA I + G +H AAQ + V+ ++ ++ +
Sbjct: 4 LLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDH 63
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
K G T H AA G + ++ L+ +G +T L LAA GH V++ L
Sbjct: 64 VDKLGRTAFHRAAEHGQLDALDFLVG---SGCDHNVKDKEGNTALHLAAGRGHMAVLQRL 120
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLD-VMRSTNTLRISSKKLGLTPLHIAAYYGQ 1210
V G ++N GLTA+H AA H + + ++R+ +T+ ++K L+ LH AA G
Sbjct: 121 VDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQK-NLSCLHYAALSG- 178
Query: 1211 AETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQ 1270
+E V +L H G + G +PLHLA + +VRLL+NS
Sbjct: 179 SEDVSRVLIHAGGCAN------------VVDHQGASPLHLAVRHNFPALVRLLINSDS-D 225
Query: 1271 ADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVE 1330
+A N PLHLA I +LL + L+ D GKT L +A H +V+
Sbjct: 226 VNAVDNRQ-QTPLHLAAEHAWQDIADMLLIAGVD-LNLRDEQGKTALAVAVRSNHVSLVD 283
Query: 1331 VLL 1333
+++
Sbjct: 284 MII 286
Score = 99 bits (238), Expect = 8e-20
Identities = 82/267 (30%), Positives = 125/267 (46%), Gaps = 20/267 (7%)
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLD-VMRSTNTLRISS 1194
L L+A GH ++++LV +GA E++ GLT +H AA+ GH VL +M + +
Sbjct: 4 LLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDH 63
Query: 1195 -KKLGLTPLHIAAYYGQAETVRELL-SHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
KLG T H AA +GQ + + L+ S VK + G T LHLAA
Sbjct: 64 VDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDK--------------EGNTALHLAA 109
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
G+ V++ L++ G+ + N G LH A G H V LLL R+ +++ +
Sbjct: 110 GRGHMAVLQRLVD-IGLDLEE-QNAEGLTALHSAAGGSHPDCVQLLL-RAGSTVNALTQK 166
Query: 1313 GKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASP 1372
+ LH A+ G + VL+ G N D G +PLH A + +V+LL S +
Sbjct: 167 NLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDV 226
Query: 1373 KSETNLNCAPIWFAASENHNDVLEYLL 1399
+ N P+ AA D+ + LL
Sbjct: 227 NAVDNRQQTPLHLAAEHAWQDIADMLL 253
Score = 99.5 bits (237), Expect = 1e-19
Identities = 75/285 (26%), Positives = 135/285 (47%), Gaps = 10/285 (3%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
++++ L+ +GA + +++ T H A G+ V+ ++ + DV AL+ + +G
Sbjct: 14 RILQILVNSGAKIHCESKDGL-TLLHCAAQKGHVPVLAFIMEDLE--DV--ALDHVDKLG 68
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
T A G + ++ L+ + +V D EG +ALHLAA G++ V L+ +
Sbjct: 69 RTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLE 128
Query: 990 SKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL 1049
+ G TALH AA + V+ L+R + ++ LT K + LH AA SG +V ++L+
Sbjct: 129 EQNAEGLTALHSAAGGSHPDCVQLLLRA-GSTVNALTQKNLSCLHYAALSGSEDVSRVLI 187
Query: 1050 ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSV 1109
G + D G P+H A ++N+ +V+L + + V A T H+AA
Sbjct: 188 HAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSD-VNAVDNRQQTPLHLAAEHAWQ 246
Query: 1110 KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRA 1154
+ + L+ GV T L +A H +V ++++A
Sbjct: 247 DIADMLL---IAGVDLNLRDEQGKTALAVAVRSNHVSLVDMIIKA 288
Score = 93.1 bits (221), Expect = 1e-17
Identities = 69/256 (26%), Positives = 125/256 (48%), Gaps = 5/256 (1%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRD-HNAMI 1022
+AL L+A G+L++ L+ + A I+ ++++G T LH AA G+ ++ F++ D + +
Sbjct: 2 NALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVAL 61
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
D + +T H AA GQ++ L+ G + + D+ G +H AA + V+Q +
Sbjct: 62 DHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLV 121
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
+L +G T H AA ++ L++ T ++A + N S L AA
Sbjct: 122 DIGLDL-EEQNAEGLTALHSAAGGSHPDCVQLLLRAGST--VNALTQKNLSC-LHYAALS 177
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
G DV RVL+ AG + G + +HLA H ++ ++ ++++ + TPL
Sbjct: 178 GSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPL 237
Query: 1203 HIAAYYGQAETVRELL 1218
H+AA + + LL
Sbjct: 238 HLAAEHAWQDIADMLL 253
Score = 79.4 bits (187), Expect = 1e-13
Identities = 46/156 (29%), Positives = 81/156 (51%), Gaps = 3/156 (1%)
Query: 1245 LTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAE 1304
+ L L+A+ G+ ++++L+NS G + S + G LH A GH+ ++ ++ +
Sbjct: 1 MNALLLSAWFGHLRILQILVNS-GAKIHCESKD-GLTLLHCAAQKGHVPVLAFIMEDLED 58
Query: 1305 L-LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVK 1363
+ L D+ G+T H A+ HG ++ L+G G + N DK G T LH AA GH+ V++
Sbjct: 59 VALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQ 118
Query: 1364 LLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
L + G + + + AA +H D ++ LL
Sbjct: 119 RLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLL 154
Score = 76.6 bits (180), Expect = 9e-13
Identities = 60/243 (24%), Positives = 106/243 (43%), Gaps = 14/243 (5%)
Query: 1166 LTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTV 1225
+ A+ L+A GH +L ++ ++ K GLT LH AA G + ++ +
Sbjct: 1 MNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVA 60
Query: 1226 KSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHL 1285
+ G T H AA +G + + L+ S G + E G LHL
Sbjct: 61 LDHVD-----------KLGRTAFHRAAEHGQLDALDFLVGS-GCDHNVKDKE-GNTALHL 107
Query: 1286 ACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKN 1345
A GHM+++ L+ +L + G T LH A+ H V++LL G+ +NA +
Sbjct: 108 AAGRGHMAVLQRLVDIGLDL-EEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQK 166
Query: 1346 GWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
+ LH AA +G +V ++L +G + +P+ A N ++ L++ + D
Sbjct: 167 NLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDV 226
Query: 1406 QSL 1408
++
Sbjct: 227 NAV 229
Score = 72.9 bits (171), Expect = 1e-11
Identities = 79/307 (25%), Positives = 135/307 (43%), Gaps = 35/307 (11%)
Query: 711 VVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLK-SGAGPNKATEDGMTPVH 769
+++ L+ GA +H K T LH AA+ A ++ + + G T H
Sbjct: 15 ILQILVNSGAKIHCES-KDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFH 73
Query: 770 VAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKD 829
AA+ G L L L+ G D K K G T L +A +++ L++ D
Sbjct: 74 RAAEHGQLDALDFLVGSGCDHNVKDK-------EGNTALHLAAGRGHMAVLQRLVDIGLD 126
Query: 830 HKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHN 889
++ + +G +ALH A + + V+ L+ G+ V+ T+ N
Sbjct: 127 ----------LEEQNAEGLTALHSAAGGSHPDC---------VQLLLRAGSTVNALTQKN 167
Query: 890 HETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLL 949
+ HY A++G+ DV +I A+V ++ Q G +PL +A LV L+
Sbjct: 168 L-SCLHYAALSGSEDVSRVLIHAGGCANV---VDHQ---GASPLHLAVRHNFPALVRLLI 220
Query: 950 TNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAH 1009
+ + V+ D ++ LHLAAEH + + D LL +N + G+TAL +A + +
Sbjct: 221 NSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDEQGKTALAVAVRSNHVS 280
Query: 1010 LVKFLIR 1016
LV +I+
Sbjct: 281 LVDMIIK 287
Score = 69.3 bits (162), Expect = 1e-10
Identities = 46/157 (29%), Positives = 79/157 (50%), Gaps = 5/157 (3%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVD-MARILVDYGAV-V 124
LLL+ G+ +++ L+++ ++ + G T LH AA++ V +A I+ D V +
Sbjct: 4 LLLSAWFGHLRILQILVNS--GAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVAL 61
Query: 125 DATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
D + G+T H AA G + + G + + D E T +HLAA GH A+++ L
Sbjct: 62 DHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLV 121
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
D + E+ +G T +H A+ H DC +L + G
Sbjct: 122 D-IGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAG 157
Score = 67.3 bits (157), Expect = 6e-10
Identities = 79/320 (24%), Positives = 136/320 (42%), Gaps = 37/320 (11%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHI-RGGK 728
+A +GH+ I+ L+ G + + D T LH A + V+ ++ DV + K
Sbjct: 7 SAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDK 66
Query: 729 QRETPLHIAARIPDGDKCAL-MLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
T H AA G AL L+ SG N ++G T +H+AA G++A L L++ G
Sbjct: 67 LGRTAFHRAAE--HGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIG 124
Query: 788 GDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDG 847
D + G T L A PD V+ L+ + + ++A+ +
Sbjct: 125 LDLEEQN-------AEGLTALHSAAGGSHPDCVQLLLR----------AGSTVNALTQKN 167
Query: 848 ASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMT 907
S LHYA E+V + LI G ++ H + H A+ N +
Sbjct: 168 LSCLHYAALSGSEDVS---------RVLIHAGGCANV-VDHQGASPLH-LAVRHNFPALV 216
Query: 908 EMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALH 967
++ + S +DV+ NRQ TPL +A + + LL +++ D +G++AL
Sbjct: 217 RLLIN-SDSDVNAVDNRQQ----TPLHLAAEHAWQDIADMLLIAGVDLNLRDEQGKTALA 271
Query: 968 LAAEHGYLQVCDALLTNKAF 987
+A ++ + D ++ F
Sbjct: 272 VAVRSNHVSLVDMIIKADRF 291
Score = 61.7 bits (143), Expect = 3e-08
Identities = 44/166 (26%), Positives = 77/166 (46%), Gaps = 3/166 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G L LA G+ ++++ L+ L+ G TALH AA D ++L+
Sbjct: 99 KEGNTALHLAAGRGHMAVLQRLVDIGL--DLEEQNAEGLTALHSAAGGSHPDCVQLLLRA 156
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G+ V+A + LH AA G E + + A + D++ +P+HLA + A++
Sbjct: 157 GSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALV 216
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHM 226
LL + + + T +H+A+ + D A ML GV L++
Sbjct: 217 RLLINS-DSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNL 261
Score = 61.3 bits (142), Expect = 4e-08
Identities = 42/157 (26%), Positives = 69/157 (43%), Gaps = 3/157 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + V+ LL A + + A T + LH AA D++R+L+ G
Sbjct: 134 GLTALHSAAGGSHPDCVQLLLRAGST--VNALTQKNLSCLHYAALSGSEDVSRVLIHAGG 191
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ + G +PLH+A LV+ ++ DN +TP+HLAAE+ I ++
Sbjct: 192 CANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADM 251
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
L + R + G T + +A + H M+ K
Sbjct: 252 LLIA-GVDLNLRDEQGKTALAVAVRSNHVSLVDMIIK 287
Score = 60.1 bits (139), Expect = 8e-08
Identities = 56/201 (27%), Positives = 93/201 (46%), Gaps = 21/201 (10%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G + H AA +G + ++ L+ G +V + TALH+A AV++ L+ G D+
Sbjct: 68 GRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDL 127
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + T LH AA D C +LL++G+ N T+ ++ +H AA G+ +
Sbjct: 128 EEQNA-EGLTALHSAAGGSHPD-CVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRV 185
Query: 783 LLEDGGDPLRKTKVCIYDV-VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
L+ GG C V G +PL +A R P +VR LI S + ++
Sbjct: 186 LIHAGG--------CANVVDHQGASPLHLAVRHNFPALVRLLIN----------SDSDVN 227
Query: 842 AVDEDGASALHYACKVTKEEV 862
AVD + LH A + +++
Sbjct: 228 AVDNRQQTPLHLAAEHAWQDI 248
Score = 57.6 bits (133), Expect = 4e-07
Identities = 78/291 (26%), Positives = 126/291 (43%), Gaps = 39/291 (13%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY--TALHIAVESCKPAVVETLLGYG 719
DG +H AA+ GHV ++ +++ E V + D TA H A E + ++ L+G G
Sbjct: 32 DGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSG 91
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALM-LLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
D +++ K+ T LH+AA G L L+ G + +G+T +H AA +
Sbjct: 92 CDHNVK-DKEGNTALHLAA--GRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPD 148
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LLL G T+ + + L A S D+ R LI H G
Sbjct: 149 CVQLLLRAGSTVNALTQKNL-------SCLHYAALSGSEDVSRVLI-----HAG-----G 191
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCA 898
+ VD GAS LH A + P +V+ LI + +DV+ + +T H A
Sbjct: 192 CANVVDHQGASPLHLAVR-----HNFPA----LVRLLINSDSDVN-AVDNRQQTPLHLAA 241
Query: 899 IAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLL 949
D+ ++ I+ D LN ++ G T L +A H+ LV+ ++
Sbjct: 242 EHAWQDIADMLL--IAGVD----LNLRDEQGKTALAVAVRSNHVSLVDMII 286
Score = 55.2 bits (127), Expect = 2e-06
Identities = 36/131 (27%), Positives = 61/131 (46%), Gaps = 2/131 (1%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K +G ++H AA GH+ ++ L+ G ++ + TALH A P V+ LL
Sbjct: 97 KDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRA 156
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
G+ V+ K LH AA + + + +L+ +G N G +P+H+A + A
Sbjct: 157 GSTVNALTQKNLSC-LHYAA-LSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPA 214
Query: 779 TLVLLLEDGGD 789
+ LL+ D
Sbjct: 215 LVRLLINSDSD 225
Score = 50.4 bits (115), Expect = 7e-05
Identities = 38/130 (29%), Positives = 61/130 (46%), Gaps = 3/130 (2%)
Query: 101 ALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI- 159
AL L+A + + +ILV+ GA + + G T LH AA +G P++ + + A+
Sbjct: 3 ALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALD 62
Query: 160 -ADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF 218
D RT H AAE+G ++ L + K+G+T +H+A+ GH L
Sbjct: 63 HVDKLGRTAFHRAAEHGQLDALDFLVGS-GCDHNVKDKEGNTALHLAAGRGHMAVLQRLV 121
Query: 219 KKGVYLHMPN 228
G+ L N
Sbjct: 122 DIGLDLEEQN 131
>BC101273-1|AAI01274.1| 399|Homo sapiens ANKDD1A protein protein.
Length = 399
Score = 103 bits (248), Expect = 5e-21
Identities = 72/257 (28%), Positives = 131/257 (50%), Gaps = 13/257 (5%)
Query: 933 LLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTN--KAFINS 990
LL++ GH++++ L+ + A++ +G + LH AA+ G++ V ++ + ++
Sbjct: 4 LLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDH 63
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIR---DHNAMIDVLTLKKQTPLHLAAASGQIEVCKL 1047
+ GRTA H AA +G + FL+ DHN V + T LHLAA G + V +
Sbjct: 64 VDKLGRTAFHRAAEHGQLDALDFLVGSGCDHN----VKDKEGNTALHLAAGRGHMAVLQR 119
Query: 1048 LLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQG 1107
L+++G +++ + G +H+AA ++ + VQL L+ + V A T+ +C H AA+ G
Sbjct: 120 LVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRA-GSTVNALTQKNLSCLHYAALSG 178
Query: 1108 SVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLT 1167
S V L+ G + ++PL LA +VR+L+ + + + T
Sbjct: 179 SEDVSRVLI---HAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQT 235
Query: 1168 AVHLAAEHGHTNVLDVM 1184
+HLAAEH ++ D++
Sbjct: 236 PLHLAAEHAWQDIADML 252
Score = 99 bits (238), Expect = 8e-20
Identities = 82/267 (30%), Positives = 125/267 (46%), Gaps = 20/267 (7%)
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLD-VMRSTNTLRISS 1194
L L+A GH ++++LV +GA E++ GLT +H AA+ GH VL +M + +
Sbjct: 4 LLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDH 63
Query: 1195 -KKLGLTPLHIAAYYGQAETVRELL-SHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
KLG T H AA +GQ + + L+ S VK + G T LHLAA
Sbjct: 64 VDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDK--------------EGNTALHLAA 109
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
G+ V++ L++ G+ + N G LH A G H V LLL R+ +++ +
Sbjct: 110 GRGHMAVLQRLVD-IGLDLEE-QNAEGLTALHSAAGGSHPDCVQLLL-RAGSTVNALTQK 166
Query: 1313 GKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASP 1372
+ LH A+ G + VL+ G N D G +PLH A + +V+LL S +
Sbjct: 167 NLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDV 226
Query: 1373 KSETNLNCAPIWFAASENHNDVLEYLL 1399
+ N P+ AA D+ + LL
Sbjct: 227 NAVDNRQQTPLHLAAEHAWQDIADMLL 253
Score = 98.7 bits (235), Expect = 2e-19
Identities = 78/253 (30%), Positives = 126/253 (49%), Gaps = 17/253 (6%)
Query: 1093 TKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+KDG T H AA +G V V+ +M+ + +KL T AAE G D + LV
Sbjct: 30 SKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLG-RTAFHRAAEHGQLDALDFLV 88
Query: 1153 RAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAE 1212
+G +++ G TA+HLAA GH VL + GLT LH AA +
Sbjct: 89 GSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPD 148
Query: 1213 TVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
V +LL TV + + L+ LH AA +G+E+V R+L+++ G A+
Sbjct: 149 CV-QLLLRAGSTVNALT------------QKNLSCLHYAALSGSEDVSRVLIHAGGC-AN 194
Query: 1273 AASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVL 1332
++ G +PLHLA ++V LL++ +++ ++ D +T LH+A+ H + ++L
Sbjct: 195 VVDHQ-GASPLHLAVRHNFPALVRLLINSDSDV-NAVDNRQQTPLHLAAEHAWQDIADML 252
Query: 1333 LGQGAEINATDKN 1345
L G ++N DK+
Sbjct: 253 LIAGVDLNLRDKD 265
Score = 94.7 bits (225), Expect = 3e-18
Identities = 66/235 (28%), Positives = 117/235 (49%), Gaps = 7/235 (2%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
++++ L+ +GA + +++ T H A G+ V+ ++ + DV AL+ + +G
Sbjct: 14 RILQILVNSGAKIHCESKDGL-TLLHCAAQKGHVPVLAFIMEDLE--DV--ALDHVDKLG 68
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFIN 989
T A G + ++ L+ + +V D EG +ALHLAA G++ V L+ +
Sbjct: 69 RTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLE 128
Query: 990 SKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL 1049
+ G TALH AA + V+ L+R + ++ LT K + LH AA SG +V ++L+
Sbjct: 129 EQNAEGLTALHSAAGGSHPDCVQLLLR-AGSTVNALTQKNLSCLHYAALSGSEDVSRVLI 187
Query: 1050 ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
G + D G P+H A ++N+ +V+L + + V A T H+AA
Sbjct: 188 HAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSD-VNAVDNRQQTPLHLAA 241
Score = 93.1 bits (221), Expect = 1e-17
Identities = 69/256 (26%), Positives = 125/256 (48%), Gaps = 5/256 (1%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRD-HNAMI 1022
+AL L+A G+L++ L+ + A I+ ++++G T LH AA G+ ++ F++ D + +
Sbjct: 2 NALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVAL 61
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
D + +T H AA GQ++ L+ G + + D+ G +H AA + V+Q +
Sbjct: 62 DHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLV 121
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
+L +G T H AA ++ L++ T ++A + N S L AA
Sbjct: 122 DIGLDL-EEQNAEGLTALHSAAGGSHPDCVQLLLRAGST--VNALTQKNLSC-LHYAALS 177
Query: 1143 GHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPL 1202
G DV RVL+ AG + G + +HLA H ++ ++ ++++ + TPL
Sbjct: 178 GSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPL 237
Query: 1203 HIAAYYGQAETVRELL 1218
H+AA + + LL
Sbjct: 238 HLAAEHAWQDIADMLL 253
Score = 89.4 bits (212), Expect = 1e-16
Identities = 84/290 (28%), Positives = 132/290 (45%), Gaps = 26/290 (8%)
Query: 1033 LHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA- 1091
L L+A G + + ++L+ GA I + G +H AAQ + V+ ++ ++ +
Sbjct: 4 LLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDH 63
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
K G T H AA G + ++ L+ +G +T L LAA GH V++ L
Sbjct: 64 VDKLGRTAFHRAAEHGQLDALDFLVG---SGCDHNVKDKEGNTALHLAAGRGHMAVLQRL 120
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLD-VMRSTNTLRISSKKLGLTPLHIAAYYGQ 1210
V G ++N GLTA+H AA H + + ++R+ +T+ ++K L+ LH AA G
Sbjct: 121 VDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQK-NLSCLHYAALSG- 178
Query: 1211 AETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQ 1270
+E V +L H G + G +PLHLA + +VRLL+NS
Sbjct: 179 SEDVSRVLIHAGGCAN------------VVDHQGASPLHLAVRHNFPALVRLLINSDS-D 225
Query: 1271 ADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELL-----HSTDRHGKT 1315
+A N PLHLA I +LL +L H +D GK+
Sbjct: 226 VNAVDNRQ-QTPLHLAAEHAWQDIADMLLIAGVDLNLRDKDHPSDPSGKS 274
Score = 79.4 bits (187), Expect = 1e-13
Identities = 46/156 (29%), Positives = 81/156 (51%), Gaps = 3/156 (1%)
Query: 1245 LTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAE 1304
+ L L+A+ G+ ++++L+NS G + S + G LH A GH+ ++ ++ +
Sbjct: 1 MNALLLSAWFGHLRILQILVNS-GAKIHCESKD-GLTLLHCAAQKGHVPVLAFIMEDLED 58
Query: 1305 L-LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVK 1363
+ L D+ G+T H A+ HG ++ L+G G + N DK G T LH AA GH+ V++
Sbjct: 59 VALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQ 118
Query: 1364 LLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
L + G + + + AA +H D ++ LL
Sbjct: 119 RLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLL 154
Score = 76.6 bits (180), Expect = 9e-13
Identities = 60/243 (24%), Positives = 106/243 (43%), Gaps = 14/243 (5%)
Query: 1166 LTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTV 1225
+ A+ L+A GH +L ++ ++ K GLT LH AA G + ++ +
Sbjct: 1 MNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVA 60
Query: 1226 KSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHL 1285
+ G T H AA +G + + L+ S G + E G LHL
Sbjct: 61 LDHVD-----------KLGRTAFHRAAEHGQLDALDFLVGS-GCDHNVKDKE-GNTALHL 107
Query: 1286 ACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKN 1345
A GHM+++ L+ +L + G T LH A+ H V++LL G+ +NA +
Sbjct: 108 AAGRGHMAVLQRLVDIGLDL-EEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQK 166
Query: 1346 GWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
+ LH AA +G +V ++L +G + +P+ A N ++ L++ + D
Sbjct: 167 NLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDV 226
Query: 1406 QSL 1408
++
Sbjct: 227 NAV 229
Score = 73.3 bits (172), Expect = 8e-12
Identities = 62/228 (27%), Positives = 103/228 (45%), Gaps = 17/228 (7%)
Query: 833 ESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHET 892
E + +D VD+ G +A H A E ++ D L+ +G D +++ + + T
Sbjct: 54 EDLEDVALDHVDKLGRTAFHRAA----EHGQLDALD-----FLVGSGCDHNVKDKEGN-T 103
Query: 893 AFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
A H A G+ V+ ++ D+ L QN+ G T L A H V LL
Sbjct: 104 ALHLAAGRGHMAVLQRLV------DIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAG 157
Query: 953 ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVK 1012
+ V+ + S LH AA G V L+ N G + LHLA + + LV+
Sbjct: 158 STVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVR 217
Query: 1013 FLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDE 1060
LI ++ ++ + ++QTPLHLAA ++ +LL G +++ D+
Sbjct: 218 LLINS-DSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDK 264
Score = 69.3 bits (162), Expect = 1e-10
Identities = 46/157 (29%), Positives = 79/157 (50%), Gaps = 5/157 (3%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVD-MARILVDYGAV-V 124
LLL+ G+ +++ L+++ ++ + G T LH AA++ V +A I+ D V +
Sbjct: 4 LLLSAWFGHLRILQILVNS--GAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVAL 61
Query: 125 DATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLA 184
D + G+T H AA G + + G + + D E T +HLAA GH A+++ L
Sbjct: 62 DHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLV 121
Query: 185 DKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
D + E+ +G T +H A+ H DC +L + G
Sbjct: 122 D-IGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAG 157
Score = 63.3 bits (147), Expect = 9e-09
Identities = 45/169 (26%), Positives = 79/169 (46%), Gaps = 3/169 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G L LA G+ ++++ L+ L+ G TALH AA D ++L+
Sbjct: 99 KEGNTALHLAAGRGHMAVLQRLVDIGL--DLEEQNAEGLTALHSAAGGSHPDCVQLLLRA 156
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G+ V+A + LH AA G E + + A + D++ +P+HLA + A++
Sbjct: 157 GSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALV 216
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
LL + + + T +H+A+ + D A ML GV L++ +K
Sbjct: 217 RLLINS-DSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDK 264
Score = 60.1 bits (139), Expect = 8e-08
Identities = 56/201 (27%), Positives = 93/201 (46%), Gaps = 21/201 (10%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G + H AA +G + ++ L+ G +V + TALH+A AV++ L+ G D+
Sbjct: 68 GRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDL 127
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ + T LH AA D C +LL++G+ N T+ ++ +H AA G+ +
Sbjct: 128 EEQNA-EGLTALHSAAGGSHPD-CVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRV 185
Query: 783 LLEDGGDPLRKTKVCIYDV-VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
L+ GG C V G +PL +A R P +VR LI S + ++
Sbjct: 186 LIHAGG--------CANVVDHQGASPLHLAVRHNFPALVRLLIN----------SDSDVN 227
Query: 842 AVDEDGASALHYACKVTKEEV 862
AVD + LH A + +++
Sbjct: 228 AVDNRQQTPLHLAAEHAWQDI 248
Score = 58.0 bits (134), Expect = 3e-07
Identities = 71/285 (24%), Positives = 123/285 (43%), Gaps = 35/285 (12%)
Query: 711 VVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLK-SGAGPNKATEDGMTPVH 769
+++ L+ GA +H K T LH AA+ A ++ + + G T H
Sbjct: 15 ILQILVNSGAKIHCES-KDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFH 73
Query: 770 VAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKD 829
AA+ G L L L+ G D K K G T L +A +++ L++ D
Sbjct: 74 RAAEHGQLDALDFLVGSGCDHNVKDK-------EGNTALHLAAGRGHMAVLQRLVDIGLD 126
Query: 830 HKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHN 889
++ + +G +ALH A + + V+ L+ G+ V+ T+ N
Sbjct: 127 ----------LEEQNAEGLTALHSAAGGSHPDC---------VQLLLRAGSTVNALTQKN 167
Query: 890 HETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLL 949
+ HY A++G+ DV +I A+V ++ Q G +PL +A LV L+
Sbjct: 168 L-SCLHYAALSGSEDVSRVLIHAGGCANV---VDHQ---GASPLHLAVRHNFPALVRLLI 220
Query: 950 TNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
+ + V+ D ++ LHLAAEH + + D LL +N + ++
Sbjct: 221 NSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKD 265
Score = 56.0 bits (129), Expect = 1e-06
Identities = 66/267 (24%), Positives = 115/267 (43%), Gaps = 31/267 (11%)
Query: 749 MLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPL 808
+L+ SGA + ++DG+T +H AA+ G++ L ++ED L + D + G T
Sbjct: 18 ILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMED----LEDVALDHVDKL-GRTAF 72
Query: 809 QMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTAD 868
A D + L+ DH + D++G +ALH A
Sbjct: 73 HRAAEHGQLDALDFLVGSGCDH----------NVKDKEGNTALHLAAG---------RGH 113
Query: 869 RQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSI 928
V++ L++ G D+ Q TA H A + D + ++ ST + AL ++N
Sbjct: 114 MAVLQRLVDIGLDLEEQNAEGL-TALHSAAGGSHPDCVQLLLRAGSTVN---ALTQKNL- 168
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
+ L A G + L+ +V D +G S LHLA H + + L+ + + +
Sbjct: 169 --SCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDV 226
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLI 1015
N+ +T LHLAA + + + L+
Sbjct: 227 NAVDNRQQTPLHLAAEHAWQDIADMLL 253
Score = 55.2 bits (127), Expect = 2e-06
Identities = 36/131 (27%), Positives = 61/131 (46%), Gaps = 2/131 (1%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K +G ++H AA GH+ ++ L+ G ++ + TALH A P V+ LL
Sbjct: 97 KDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRA 156
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
G+ V+ K LH AA + + + +L+ +G N G +P+H+A + A
Sbjct: 157 GSTVNALTQKNLSC-LHYAA-LSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPA 214
Query: 779 TLVLLLEDGGD 789
+ LL+ D
Sbjct: 215 LVRLLINSDSD 225
Score = 54.8 bits (126), Expect = 3e-06
Identities = 72/282 (25%), Positives = 117/282 (41%), Gaps = 37/282 (13%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHI-RGGK 728
+A +GH+ I+ L+ G + + D T LH A + V+ ++ DV + K
Sbjct: 7 SAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDK 66
Query: 729 QRETPLHIAARIPDGDKCAL-MLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
T H AA G AL L+ SG N ++G T +H+AA G++A L L++ G
Sbjct: 67 LGRTAFHRAAE--HGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIG 124
Query: 788 GDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDG 847
D + G T L A PD V+ L+ + + ++A+ +
Sbjct: 125 LDLEEQN-------AEGLTALHSAAGGSHPDCVQLLLR----------AGSTVNALTQKN 167
Query: 848 ASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMT 907
S LHYA E+V + LI G ++ H + H A+ N +
Sbjct: 168 LSCLHYAALSGSEDVS---------RVLIHAGGCANV-VDHQGASPLH-LAVRHNFPALV 216
Query: 908 EMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLL 949
++ + S +DV+ NRQ TPL +A + + LL
Sbjct: 217 RLLIN-SDSDVNAVDNRQQ----TPLHLAAEHAWQDIADMLL 253
Score = 50.4 bits (115), Expect = 7e-05
Identities = 38/130 (29%), Positives = 61/130 (46%), Gaps = 3/130 (2%)
Query: 101 ALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI- 159
AL L+A + + +ILV+ GA + + G T LH AA +G P++ + + A+
Sbjct: 3 ALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALD 62
Query: 160 -ADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF 218
D RT H AAE+G ++ L + K+G+T +H+A+ GH L
Sbjct: 63 HVDKLGRTAFHRAAEHGQLDALDFLVGS-GCDHNVKDKEGNTALHLAAGRGHMAVLQRLV 121
Query: 219 KKGVYLHMPN 228
G+ L N
Sbjct: 122 DIGLDLEEQN 131
Score = 49.6 bits (113), Expect = 1e-04
Identities = 57/198 (28%), Positives = 87/198 (43%), Gaps = 23/198 (11%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNY--TALHIAVESCKPAVVETLLGYG 719
DG +H AA+ GHV ++ +++ E V + D TA H A E + ++ L+G G
Sbjct: 32 DGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSG 91
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALM-LLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
D +++ K+ T LH+AA G L L+ G + +G+T +H AA +
Sbjct: 92 CDHNVK-DKEGNTALHLAA--GRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPD 148
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ LLL G T+ + + L A S D+ R LI H G
Sbjct: 149 CVQLLLRAGSTVNALTQKNL-------SCLHYAALSGSEDVSRVLI-----HAG-----G 191
Query: 839 FIDAVDEDGASALHYACK 856
+ VD GAS LH A +
Sbjct: 192 CANVVDHQGASPLHLAVR 209
Score = 39.5 bits (88), Expect = 0.13
Identities = 18/63 (28%), Positives = 30/63 (47%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
GA +H A R+ ++ L+ V+ N T LH+A E + + LL G D+
Sbjct: 200 GASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDL 259
Query: 723 HIR 725
++R
Sbjct: 260 NLR 262
>AB051515-1|BAB21819.1| 1644|Homo sapiens KIAA1728 protein protein.
Length = 1644
Score = 103 bits (247), Expect = 7e-21
Identities = 94/323 (29%), Positives = 160/323 (49%), Gaps = 22/323 (6%)
Query: 866 TADRQVVKCLIENGADVSLQTRH-NHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNR 924
T + +V + LI GA+V+ +T N+ + G+ +V+T ++ + L+
Sbjct: 693 TPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLL------EFGACLDG 746
Query: 925 QNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLT- 983
+ G T L A GHM+LV L RVD D +G+ AL +A G+ + LLT
Sbjct: 747 TSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTC 806
Query: 984 ------NKAFINSKARNGRTALHLAAMNGYAHLVKFLI---RDHNAMID-VLTLKKQTPL 1033
+ K+ + AL AA G++ +V+ L+ ++H ++ TL +T L
Sbjct: 807 EWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETAL 866
Query: 1034 HLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT 1093
AA G++EVC+LLL GA + T+ G P+ AA+ + ++V+L L++ + V +
Sbjct: 867 TAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCD-VNLSD 925
Query: 1094 KDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR 1153
K G T +AA +G + +E L+ + +S+ +K + L A GH VV+ LV
Sbjct: 926 KQGRTPLMVAACEGHLSTVEFLL--SKGAALSSLDK-EGLSALSWACLKGHRAVVQYLVE 982
Query: 1154 AGASCTDENRAGLTAVHLAAEHG 1176
GA+ ++ G T + LAA +G
Sbjct: 983 EGAAIDQTDKNGRTPLDLAAFYG 1005
Score = 102 bits (244), Expect = 2e-20
Identities = 112/374 (29%), Positives = 167/374 (44%), Gaps = 34/374 (9%)
Query: 1042 IEVCKLLLELGANID-ATDELGQKPIHAAAQN-NYSEVVQLFLQQHPNLVMATTKDGNTC 1099
++V +LL+ GAN++ T+ L PI + + EVV L L+ L T+++G T
Sbjct: 696 VKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLD-GTSENGMTA 754
Query: 1100 AHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGAS-- 1157
AA G +K++ L K GV L +A GH D+++ L+ S
Sbjct: 755 LCYAAAAGHMKLVCLLTK---KGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 811
Query: 1158 -----CTDENRAGLTAVHLAAEHGHTNVLDV---MRSTNTLRISSKKL--GLTPLHIAAY 1207
++ A A+ AA GH++V+ M + + ++ G T L AA
Sbjct: 812 PPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAG 871
Query: 1208 YGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSA 1267
G+ E LL H ++ G+ PL AA G+ +VRLLL
Sbjct: 872 RGKLEVCELLLGHGAAVSRTN-------------RRGVPPLFCAARQGHWQIVRLLLER- 917
Query: 1268 GVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQ 1327
G + S++ G PL +A GH+S V LLS+ A L S D+ G + L A GH
Sbjct: 918 GCDVNL-SDKQGRTPLMVAACEGHLSTVEFLLSKGAAL-SSLDKEGLSALSWACLKGHRA 975
Query: 1328 MVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAA 1387
+V+ L+ +GA I+ TDKNG TPL AA G V L E GA + + P+ A
Sbjct: 976 VVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAI 1035
Query: 1388 SENHNDVLEYLLHK 1401
+ V+ LL K
Sbjct: 1036 GCRNTSVVVALLRK 1049
Score = 95.1 bits (226), Expect = 2e-18
Identities = 106/390 (27%), Positives = 171/390 (43%), Gaps = 38/390 (9%)
Query: 715 LLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKF 774
+LG GA+V+ R P+ ++ +LL+ GA + +E+GMT + AA
Sbjct: 703 ILG-GANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAA 761
Query: 775 GNLATLVLLLEDGG--DPLRKTKVC--IYDVVTGETPLQMACRSCMPDIVRHLIEFVKDH 830
G++ + LL + G D L K C ++ + G + +C ++
Sbjct: 762 GHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLR-- 819
Query: 831 KGESVSTAFIDAVDEDGASALHYACKVTKE-EVKIPTADRQVVKCLIENGADVSLQTRHN 889
K ++ A A +S + + KE EV++ NG D
Sbjct: 820 KSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEV-------------NGTDTLWG---- 862
Query: 890 HETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLL 949
ETA A G +V ++ H A++R N G PL A +GH Q+V LL
Sbjct: 863 -ETALTAAAGRGKLEVCELLLGH------GAAVSRTNRRGVPPLFCAARQGHWQIVRLLL 915
Query: 950 TNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAH 1009
V++ D +GR+ L +AA G+L + LL+ A ++S + G +AL A + G+
Sbjct: 916 ERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRA 975
Query: 1010 LVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA 1069
+V++L+ + A ID +TPL LAA G E L+E GA I+ D G +P+ A
Sbjct: 976 VVQYLV-EEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRA 1034
Query: 1070 AQNNYSEVVQLFLQQHPNL-----VMATTK 1094
+ VV L++ L MAT+K
Sbjct: 1035 IGCRNTSVVVALLRKGAKLGNAAWAMATSK 1064
Score = 93.9 bits (223), Expect = 6e-18
Identities = 96/340 (28%), Positives = 151/340 (44%), Gaps = 26/340 (7%)
Query: 1040 GQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTC 1099
G EV LLLE GA +D T E G + AA + ++V L ++ + K
Sbjct: 729 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 788
Query: 1100 AHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQ----LAAEGGHADVVRVLVRAG 1155
H +A++G +++ L+ + + L S LQ AA GH+ VV+ L+
Sbjct: 789 VH-SALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGME 847
Query: 1156 ASCTDENRA-----GLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQ 1210
E G TA+ AA G V +++ + + G+ PL AA G
Sbjct: 848 KEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGH 907
Query: 1211 AETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQ 1270
+ VR LL E V+L + G TPL +AA G+ + V LL+
Sbjct: 908 WQIVRLLL---------ERGCDVNL----SDKQGRTPLMVAACEGHLSTVEFLLSKGA-- 952
Query: 1271 ADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVE 1330
A ++ ++ G + L AC GH ++V L+ A + TD++G+T L +A+ +G + V
Sbjct: 953 ALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAI-DQTDKNGRTPLDLAAFYGDAETVL 1011
Query: 1331 VLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
L+ +GA I D +G PL A + +VV L GA
Sbjct: 1012 YLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1051
Score = 79.8 bits (188), Expect = 1e-13
Identities = 55/171 (32%), Positives = 83/171 (48%), Gaps = 9/171 (5%)
Query: 1290 GHMSIVGLLLSRSAEL---LHSTDR-HGKTGLHIASTHGHYQMVEVLLGQGAEINATDKN 1345
GH S+V LL E ++ TD G+T L A+ G ++ E+LLG GA ++ T++
Sbjct: 835 GHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRR 894
Query: 1346 GWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
G PL CAA+ GH +V+LL E G P+ AA E H +E+LL K
Sbjct: 895 GVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAAL 954
Query: 1406 QSLMDDKRFVYNL-MVCSKNHNNIPIEEFVLVSPAPVDTAAKLSNIYINLS 1455
SL DK + L C K H + ++++ A +D K ++L+
Sbjct: 955 SSL--DKEGLSALSWACLKGHR--AVVQYLVEEGAAIDQTDKNGRTPLDLA 1001
Score = 77.4 bits (182), Expect = 5e-13
Identities = 49/166 (29%), Positives = 83/166 (50%), Gaps = 4/166 (2%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKAT---TPAGDTALHLAARRRDVDMARILVDYGAV 123
L A G+ S+V+ LL + +++ T G+TAL AA R +++ +L+ +GA
Sbjct: 828 LTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAA 887
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
V TN G PL AA +G +V+ + ++D + RTP+ +AA GH + +E L
Sbjct: 888 VSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFL 947
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
K A++ K+G + + A L GH L ++G + +K
Sbjct: 948 LSK-GAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDK 992
Score = 74.5 bits (175), Expect = 4e-12
Identities = 85/324 (26%), Positives = 144/324 (44%), Gaps = 24/324 (7%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
+VV L+E GA + T N TA Y A AG+ +++ ++ V ++ + G
Sbjct: 732 EVVTLLLEFGACLD-GTSENGMTALCYAAAAGH----MKLVCLLTKKGVR--VDHLDKKG 784
Query: 930 WTPLLIACHRGHMQLVNTLLT-----NHARVDVFDVEG--RSALHLAAEHGYLQVCDALL 982
L+ + RGH ++ LLT + + AL AA G+ V LL
Sbjct: 785 QCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLL 844
Query: 983 ----TNKAFIN-SKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAA 1037
++ +N + G TAL AA G + + L+ H A + + PL AA
Sbjct: 845 GMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLL-GHGAAVSRTNRRGVPPLFCAA 903
Query: 1038 ASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGN 1097
G ++ +LLLE G +++ +D+ G+ P+ AA + V+ L + L + K+G
Sbjct: 904 RQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAAL-SSLDKEGL 962
Query: 1098 TCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGAS 1157
+ A ++G V++ L++ G + N TPL LAA G A+ V LV GA
Sbjct: 963 SALSWACLKGHRAVVQYLVE---EGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAV 1019
Query: 1158 CTDENRAGLTAVHLAAEHGHTNVL 1181
+ +G+ + A +T+V+
Sbjct: 1020 IEHVDHSGMRPLDRAIGCRNTSVV 1043
Score = 66.1 bits (154), Expect = 1e-09
Identities = 45/162 (27%), Positives = 78/162 (48%), Gaps = 3/162 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L A G + LL A + T G L AAR+ + R+L++ G
Sbjct: 862 GETALTAAAGRGKLEVCELLLGHGAA--VSRTNRRGVPPLFCAARQGHWQIVRLLLERGC 919
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+ ++ G+TPL +AA EG V++ A + D E + + A GH A+++
Sbjct: 920 DVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQY 979
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
L ++ A+I + K+G T + +A+ G A+ + L +KG +
Sbjct: 980 LVEE-GAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVI 1020
Score = 55.6 bits (128), Expect = 2e-06
Identities = 40/136 (29%), Positives = 65/136 (47%), Gaps = 9/136 (6%)
Query: 1265 NSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTH- 1323
++ G+ A AS N Y P ++ + LL+ A + + T+ + +H
Sbjct: 677 STEGLSAALASLRNLYTP--------NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHL 728
Query: 1324 GHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPI 1383
GH ++V +LL GA ++ T +NG T L AA AGH+ +V LL + G +
Sbjct: 729 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 788
Query: 1384 WFAASENHNDVLEYLL 1399
+A H D+L+YLL
Sbjct: 789 VHSALRGHGDILQYLL 804
Score = 51.6 bits (118), Expect = 3e-05
Identities = 38/126 (30%), Positives = 60/126 (47%), Gaps = 2/126 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G+ PL++A G+ S V LLS A L + G +AL A + + + LV+
Sbjct: 926 KQGRTPLMVAACEGHLSTVEFLLSKGAA--LSSLDKEGLSALSWACLKGHRAVVQYLVEE 983
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA +D T+ G+TPL +AA GD V Y A D+ P+ A + +++
Sbjct: 984 GAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV 1043
Query: 181 ELLADK 186
L K
Sbjct: 1044 VALLRK 1049
Score = 49.6 bits (113), Expect = 1e-04
Identities = 35/126 (27%), Positives = 63/126 (50%), Gaps = 4/126 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G + AAR GH I+ LL++G V+++ T L +A + VE LL GA +
Sbjct: 895 GVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAAL 954
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALM-LLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+E ++ G + + L++ GA ++ ++G TP+ +AA +G+ T++
Sbjct: 955 ---SSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVL 1011
Query: 782 LLLEDG 787
L+E G
Sbjct: 1012 YLVEKG 1017
Score = 49.2 bits (112), Expect = 2e-04
Identities = 86/296 (29%), Positives = 128/296 (43%), Gaps = 45/296 (15%)
Query: 667 IHTAARYGHVGIINTLL----QKGESVDVTTNDNYT---ALHIAVESCKPAVVETLLGYG 719
+H+A R GH I+ LL G T ++ AL A +VV+ LLG
Sbjct: 789 VHSALR-GHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGME 847
Query: 720 AD--VHIRGGKQR--ETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
+ V + G ET L AA + C L LL GA ++ G+ P+ AA+ G
Sbjct: 848 KEHEVEVNGTDTLWGETALTAAAGRGKLEVCEL-LLGHGAAVSRTNRRGVPPLFCAARQG 906
Query: 776 NLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESV 835
+ + LLLE G D K G TPL +A +C + +EF+ KG ++
Sbjct: 907 HWQIVRLLLERGCDVNLSDK-------QGRTPLMVA--ACEGHL--STVEFLLS-KGAAL 954
Query: 836 STAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFH 895
S+ +D++G SAL +AC R VV+ L+E GA + QT N T
Sbjct: 955 SS-----LDKEGLSALSWACL---------KGHRAVVQYLVEEGAAID-QTDKNGRTPLD 999
Query: 896 YCAIAGNNDVMTEMI---AHISTADVS--RALNRQNSIGWTPLLIACHRGHMQLVN 946
A G+ + + ++ A I D S R L+R T +++A R +L N
Sbjct: 1000 LAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGN 1055
Score = 48.0 bits (109), Expect = 4e-04
Identities = 36/126 (28%), Positives = 55/126 (43%), Gaps = 2/126 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+RG PL A G+ +VR LL + + + G T L +AA + L+
Sbjct: 893 RRGVPPLFCAARQGHWQIVRLLL--ERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSK 950
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA + + + G + L A +G +V+Y A D RTP+ LAA G A +
Sbjct: 951 GAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETV 1010
Query: 181 ELLADK 186
L +K
Sbjct: 1011 LYLVEK 1016
>AK222715-1|BAD96435.1| 512|Homo sapiens ankyrin repeat and SOCS
box-containing protein 3 isoform a variant protein.
Length = 512
Score = 102 bits (244), Expect = 2e-20
Identities = 83/268 (30%), Positives = 124/268 (46%), Gaps = 22/268 (8%)
Query: 1138 LAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM----RSTNTLRIS 1193
LAA + V+R L++ G S + G +H AA H L ++ S N +++
Sbjct: 10 LAAREANVKVLRQLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 69
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAY 1253
+ + G LH+AA G + V+ LL P +L TPL LA
Sbjct: 70 TFE-GFCALHLAASQGHWKIVQILLE------AGADPNATTLEET-------TPLFLAVE 115
Query: 1254 NGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHG 1313
NG +V+RLLL G + + + G+N LH A F + I+ LLL + A D G
Sbjct: 116 NGQIDVLRLLLQH-GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANK-ECQDDFG 173
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPK 1373
T L +A+ +G + + +L+ GA +N + TPL AA+ GH V+LL SGA P
Sbjct: 174 ITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD 233
Query: 1374 SETNLNC--APIWFAASENHNDVLEYLL 1399
N + PI AA H +L+ L+
Sbjct: 234 LYCNEDSWQLPIHAAAQMGHTKILDLLI 261
Score = 93.1 bits (221), Expect = 1e-17
Identities = 71/239 (29%), Positives = 116/239 (48%), Gaps = 14/239 (5%)
Query: 1167 TAVHLAAEHGHTNVL-DVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTV 1225
+ V LAA + VL +++ ++ ++ + G P+H AAY+ E ++ L++
Sbjct: 6 STVGLAAREANVKVLRQLLKKGRSVDVADNR-GWMPIHEAAYHNSVECLQMLIN------ 58
Query: 1226 KSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHL 1285
A + + + + E G LHLAA G+ +V++LL AG +A + E PL L
Sbjct: 59 ---ADSSENYIKMKTFE-GFCALHLAASQGHWKIVQILLE-AGADPNATTLEET-TPLFL 112
Query: 1286 ACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKN 1345
A G + ++ LLL A + S G LH AS + +++++LL +GA D
Sbjct: 113 AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDF 172
Query: 1346 GWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G TPL AA+ G L + +L SGA+ + P++ AA E H +E LL D
Sbjct: 173 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD 231
Score = 90.6 bits (215), Expect = 5e-17
Identities = 72/271 (26%), Positives = 126/271 (46%), Gaps = 11/271 (4%)
Query: 920 RALNRQNSIGWTPLLIACHRGHMQLVNTLLT-----NHARVDVFDVEGRSALHLAAEHGY 974
R+++ ++ GW P+ A + ++ + L+ N+ ++ F EG ALHLAA G+
Sbjct: 28 RSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTF--EGFCALHLAASQGH 85
Query: 975 LQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMID-VLTLKKQTPL 1033
++ LL A N+ T L LA NG +++ L++ H A ++ ++ L
Sbjct: 86 WKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ-HGANVNGSHSMCGWNSL 144
Query: 1034 HLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT 1093
H A+ E+ KLLL GAN + D+ G P+ AAQ E + + + N V
Sbjct: 145 HQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGAN-VNCQA 203
Query: 1094 KDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR 1153
D T IAA +G K +E L+ + N+ + P+ AA+ GH ++ +L+
Sbjct: 204 LDKATPLFIAAQEGHTKCVELLLSSGADPDLYC-NEDSWQLPIHAAAQMGHTKILDLLIP 262
Query: 1154 AGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
D ++ V+ A GH + L+++
Sbjct: 263 LTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 293
Score = 89.0 bits (211), Expect = 2e-16
Identities = 83/315 (26%), Positives = 153/315 (48%), Gaps = 23/315 (7%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA--M 1021
S + LAA ++V LL ++ G +H AA + ++ LI ++
Sbjct: 6 STVGLAAREANVKVLRQLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENY 65
Query: 1022 IDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
I + T + LHLAA+ G ++ ++LLE GA+ +AT P+ A +N +V++L
Sbjct: 66 IKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLL 125
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAE 1141
LQ N+ + + G H A+ Q + ++I+ L+ R G TPL +AA+
Sbjct: 126 LQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLL---RKGANKECQDDFGITPLFVAAQ 182
Query: 1142 GGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT---LRISSKKLG 1198
G + + +L+ +GA+ + T + +AA+ GHT ++++ S+ L +
Sbjct: 183 YGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQ 242
Query: 1199 LTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNEN 1258
L P+H AA G + + +LL +P T ++ TG++ V +P++ A + G+E+
Sbjct: 243 L-PIHAAAQMGHTK-ILDLL--IPLTNRA-CDTGLNKV---------SPVYSAVFGGHED 288
Query: 1259 VVRLLLNSAGVQADA 1273
+ +LL + G DA
Sbjct: 289 CLEILLRN-GYSPDA 302
Score = 83.4 bits (197), Expect = 8e-15
Identities = 80/312 (25%), Positives = 142/312 (45%), Gaps = 18/312 (5%)
Query: 1069 AAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
AA+ +V++ L++ ++ +A + G H AA SV+ ++ L+ D +
Sbjct: 11 AAREANVKVLRQLLKKGRSVDVADNR-GWMPIHEAAYHNSVECLQMLINADSSENYIKMK 69
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTN 1188
L LAA GH +V++L+ AGA T + LA E+G +VL ++
Sbjct: 70 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 129
Query: 1189 T-LRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
+ S G LH A++ AE ++ LL G K + G+TP
Sbjct: 130 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK--GANKE-----------CQDDFGITP 176
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL-L 1306
L +AA G + +L++S G + + + PL +A GH V LLLS A+ L
Sbjct: 177 LFVAAQYGKLESLSILISS-GANVNCQALDKA-TPLFIAAQEGHTKCVELLLSSGADPDL 234
Query: 1307 HSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
+ + + +H A+ GH +++++L+ T N +P++ A GH + +++L
Sbjct: 235 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 294
Query: 1367 ESGASPKSETNL 1378
+G SP ++ L
Sbjct: 295 RNGYSPDAQACL 306
Score = 72.5 bits (170), Expect = 1e-11
Identities = 44/133 (33%), Positives = 71/133 (53%), Gaps = 1/133 (0%)
Query: 657 KYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLL 716
K K F+G ++H AA GH I+ LL+ G + TT + T L +AVE+ + V+ LL
Sbjct: 67 KMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL 126
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
+GA+V+ LH A + + +LL+ GA + G+TP+ VAA++G
Sbjct: 127 QHGANVNGSHSMCGWNSLH-QASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGK 185
Query: 777 LATLVLLLEDGGD 789
L +L +L+ G +
Sbjct: 186 LESLSILISSGAN 198
Score = 58.4 bits (135), Expect = 3e-07
Identities = 42/124 (33%), Positives = 64/124 (51%), Gaps = 4/124 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G S+H A+ + II LL+KG + + + T L +A + K + L+ GA+V
Sbjct: 140 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 199
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPN-KATEDG-MTPVHVAAKFGNLATL 780
+ + + TPL IAA+ KC +LL SGA P+ ED P+H AA+ G+ L
Sbjct: 200 NCQ-ALDKATPLFIAAQ-EGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKIL 257
Query: 781 VLLL 784
LL+
Sbjct: 258 DLLI 261
Score = 56.8 bits (131), Expect = 8e-07
Identities = 41/138 (29%), Positives = 66/138 (47%), Gaps = 3/138 (2%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
D ++ AAR +V ++ LL+KG SVDV N + +H A ++ L+ +
Sbjct: 3 DTCSTVGLAAREANVKVLRQLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSS 62
Query: 722 VHIRGGKQRE--TPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
+ K E LH+AA K +LL++GA PN T + TP+ +A + G +
Sbjct: 63 ENYIKMKTFEGFCALHLAASQGHW-KIVQILLEAGADPNATTLEETTPLFLAVENGQIDV 121
Query: 780 LVLLLEDGGDPLRKTKVC 797
L LLL+ G + +C
Sbjct: 122 LRLLLQHGANVNGSHSMC 139
Score = 55.6 bits (128), Expect = 2e-06
Identities = 42/146 (28%), Positives = 67/146 (45%), Gaps = 2/146 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LAVE G ++R LL A + + G +LH A+ + + ++ ++L+ GA +
Sbjct: 109 PLFLAVENGQIDVLRLLLQ-HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 167
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ G TPL +AA G + AN + TP+ +AA+ GH +ELL
Sbjct: 168 CQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLS 227
Query: 186 KFKASIFERTKDGSTL-MHIASLNGH 210
+D L +H A+ GH
Sbjct: 228 SGADPDLYCNEDSWQLPIHAAAQMGH 253
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/126 (30%), Positives = 61/126 (48%), Gaps = 3/126 (2%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G T L +AA+ ++ IL+ GA V+ TPL IAA EG V+ A+
Sbjct: 173 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADP 232
Query: 158 AIADNED--RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAM 215
+ NED + P+H AA+ GH I++LL + + + + ++ A GH DC
Sbjct: 233 DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRAC-DTGLNKVSPVYSAVFGGHEDCLE 291
Query: 216 MLFKKG 221
+L + G
Sbjct: 292 ILLRNG 297
Score = 50.0 bits (114), Expect = 9e-05
Identities = 41/181 (22%), Positives = 75/181 (41%), Gaps = 5/181 (2%)
Query: 69 LAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA---VVD 125
LA N ++R+LL + + G +H AA V+ ++L++ + +
Sbjct: 10 LAAREANVKVLRQLL--KKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIK 67
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
G LH+AA++G +V+ A+ E+ TP+ LA ENG ++ LL
Sbjct: 68 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 127
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDEVLFVKIE 245
+ G +H AS +A+ +L +KG + + F + K+E
Sbjct: 128 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 187
Query: 246 N 246
+
Sbjct: 188 S 188
Score = 48.4 bits (110), Expect = 3e-04
Identities = 36/122 (29%), Positives = 61/122 (50%), Gaps = 3/122 (2%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTND-NYTALHIAVESCKPAVVETLLGYGADVHIRGGK 728
A G + ++ LLQ G +V+ + + + +LH A +++ LL GA+ +
Sbjct: 113 AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDF 172
Query: 729 QRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGG 788
TPL +AA+ + ++ L+ SGA N D TP+ +AA+ G+ + LLL G
Sbjct: 173 GI-TPLFVAAQYGKLESLSI-LISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGA 230
Query: 789 DP 790
DP
Sbjct: 231 DP 232
>BC028369-1|AAH28369.1| 617|Homo sapiens fem-1 homolog c (C. elegans)
protein.
Length = 617
Score = 101 bits (243), Expect = 2e-20
Identities = 74/239 (30%), Positives = 117/239 (48%), Gaps = 13/239 (5%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLR-----ISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
TAV AA G +L + ++ + IS K G TPL +AA YG + V LL
Sbjct: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
Query: 1222 PGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYN 1281
+++ + GA PL A+ G+ VV+ LLN G + + N
Sbjct: 65 SASIEVGGSVNFDGETIEGAP----PLWAASAAGHLKVVQSLLNH-GASVNNTTLTNS-T 118
Query: 1282 PLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINA 1341
PL ACF GH+ IV L+ A+L ++RHG T L I+ GH ++ + LL +GA++N
Sbjct: 119 PLRAACFDGHLEIVKYLVEHKADL-EVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNR 177
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
G T LH A++G L+++K+L A + + P+ A+ H +++++L H
Sbjct: 178 KSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKD-GYGMTPLLSASVTGHTNIVDFLTH 235
Score = 90.2 bits (214), Expect = 7e-17
Identities = 69/252 (27%), Positives = 135/252 (53%), Gaps = 22/252 (8%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKA-----FINSKARNGRTALHLAAMNGYAHLVKFLIRD 1017
++A+ AA G L++ LL +K+ + S+ NG T L +AA G+ +V+FL+
Sbjct: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ 63
Query: 1018 HNAMIDV--------LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA 1069
+A I+V T++ PL A+A+G ++V + LL GA+++ T P+ AA
Sbjct: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNK 1129
+ + E+V+ +L +H + + + G+TC I+ +G ++ + L++ G R
Sbjct: 124 CFDGHLEIVK-YLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLE---KGADVNRKS 179
Query: 1130 LNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM----R 1185
+ +T L AE G D++++L+ A +++ G+T + A+ GHTN++D + +
Sbjct: 180 VKGNTALHDCAESGSLDIMKMLLMYCAK-MEKDGYGMTPLLSASVTGHTNIVDFLTHHAQ 238
Query: 1186 STNTLRISSKKL 1197
++ T RI++ +L
Sbjct: 239 TSKTERINALEL 250
Score = 87.8 bits (208), Expect = 4e-16
Identities = 67/249 (26%), Positives = 120/249 (48%), Gaps = 13/249 (5%)
Query: 891 ETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLT 950
+TA A G ++T+++A S +VS ++ + + G TPLL+A GH+ +V LL
Sbjct: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTN-GATPLLMAARYGHLDMVEFLLE 62
Query: 951 N-HARVDV-----FD---VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A ++V FD +EG L A+ G+L+V +LL + A +N+ T L
Sbjct: 63 QCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRA 122
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A +G+ +VK+L+ +H A ++V T L ++ G E+ + LLE GA+++
Sbjct: 123 ACFDGHLEIVKYLV-EHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK 181
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
G +H A++ +++++ L M G T A++ G +++ L +T
Sbjct: 182 GNTALHDCAESGSLDIMKMLLMYCAK--MEKDGYGMTPLLSASVTGHTNIVDFLTHHAQT 239
Query: 1122 GVISARNKL 1130
N L
Sbjct: 240 SKTERINAL 248
Score = 73.3 bits (172), Expect = 8e-12
Identities = 52/205 (25%), Positives = 102/205 (49%), Gaps = 6/205 (2%)
Query: 884 LQTRHNHETAFHYCAIAGNNDVMTEMIAHISTA-DVSRALNRQNSI--GWTPLLIACHRG 940
+ + N T A G+ D++ ++ S + +V ++N G PL A G
Sbjct: 35 ISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAG 94
Query: 941 HMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALH 1000
H+++V +LL + A V+ + + L A G+L++ L+ +KA + R+G T L
Sbjct: 95 HLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLM 154
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDE 1060
++ G+ + ++L+ + A ++ ++K T LH A SG +++ K+LL A ++ D
Sbjct: 155 ISCYKGHKEIAQYLL-EKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDG 212
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQH 1085
G P+ +A+ ++ +V FL H
Sbjct: 213 YGMTPLLSASVTGHTNIVD-FLTHH 236
Score = 72.1 bits (169), Expect = 2e-11
Identities = 75/252 (29%), Positives = 110/252 (43%), Gaps = 20/252 (7%)
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
D T V AA+ G L L LL + I + G TPL MA R D+V
Sbjct: 2 DLKTAVFNAARDGKLRLLTKLLASKSK--EEVSSLISEKTNGATPLLMAARYGHLDMVEF 59
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L+E S F D +GA L A +VV+ L+ +GA V
Sbjct: 60 LLEQCSASIEVGGSVNF-DGETIEGAPPLWAAS---------AAGHLKVVQSLLNHGASV 109
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ T N T G+ +++ ++ H + +VS N G T L+I+C++GH
Sbjct: 110 NNTTLTN-STPLRAACFDGHLEIVKYLVEHKADLEVS------NRHGHTCLMISCYKGHK 162
Query: 943 QLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLA 1002
++ LL A V+ V+G +ALH AE G L + LL A + K G T L A
Sbjct: 163 EIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKM-EKDGYGMTPLLSA 221
Query: 1003 AMNGYAHLVKFL 1014
++ G+ ++V FL
Sbjct: 222 SVTGHTNIVDFL 233
Score = 69.3 bits (162), Expect = 1e-10
Identities = 61/230 (26%), Positives = 107/230 (46%), Gaps = 28/230 (12%)
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRST--------NTLRISSKKL-GLTPLHIAA 1206
+S E G T + +AA +GH ++++ + ++ + + G PL A+
Sbjct: 32 SSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAAS 91
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS 1266
G + V+ LL+H G S+ S TPL A ++G+ +V+ L+
Sbjct: 92 AAGHLKVVQSLLNH-----------GASVNNTTLTNS--TPLRAACFDGHLEIVKYLVEH 138
Query: 1267 AGVQADA-ASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGH 1325
+AD SN +G+ L ++C+ GH I LL + A++ + + G T LH + G
Sbjct: 139 ---KADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK-GNTALHDCAESGS 194
Query: 1326 YQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSE 1375
++++LL A++ D G TPL A+ GH N+V L + K+E
Sbjct: 195 LDIMKMLLMYCAKMEK-DGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTE 243
Score = 68.1 bits (159), Expect = 3e-10
Identities = 54/170 (31%), Positives = 78/170 (45%), Gaps = 11/170 (6%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAG---VQADAASNENGYNPLHLACFGGHMSIVGLLL--- 1299
T + AA +G ++ LL S V + + NG PL +A GH+ +V LL
Sbjct: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
Query: 1300 SRSAELLHSTDRHGKT-----GLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
S S E+ S + G+T L AS GH ++V+ LL GA +N T TPL A
Sbjct: 65 SASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAAC 124
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
GHL +VK L E A + + + + H ++ +YLL K D
Sbjct: 125 FDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGAD 174
Score = 62.5 bits (145), Expect = 2e-08
Identities = 54/166 (32%), Positives = 80/166 (48%), Gaps = 17/166 (10%)
Query: 1297 LLLSRSAE---LLHSTDRHGKTGLHIASTHGHYQMVEVLLGQ-------GAEINATDKN- 1345
LL S+S E L S +G T L +A+ +GH MVE LL Q G +N +
Sbjct: 22 LLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETI 81
Query: 1346 -GWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G PL A+ AGHL VV+ L GAS + T N P+ A + H ++++YL+ EH
Sbjct: 82 EGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLV--EHK 139
Query: 1405 TQSLMDDKRFVYNLMV-CSKNHNNIPIEEFVLVSPAPVDTAAKLSN 1449
+ ++ LM+ C K H I +++L A V+ + N
Sbjct: 140 ADLEVSNRHGHTCLMISCYKGHKE--IAQYLLEKGADVNRKSVKGN 183
Score = 59.7 bits (138), Expect = 1e-07
Identities = 45/175 (25%), Positives = 80/175 (45%), Gaps = 10/175 (5%)
Query: 52 KKLIRDLVFQR--GKVPLLLAVEAGNQSMVRELLSAQTAE-------QLKATTPAGDTAL 102
K+ + L+ ++ G PLL+A G+ MV LL +A T G L
Sbjct: 28 KEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPL 87
Query: 103 HLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADN 162
A+ + + + L+++GA V+ T TPL A +G +VKY +A+ +++
Sbjct: 88 WAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNR 147
Query: 163 EDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
T + ++ GH I + L +K A + ++ G+T +H + +G D ML
Sbjct: 148 HGHTCLMISCYKGHKEIAQYLLEK-GADVNRKSVKGNTALHDCAESGSLDIMKML 201
Score = 58.8 bits (136), Expect = 2e-07
Identities = 66/249 (26%), Positives = 104/249 (41%), Gaps = 28/249 (11%)
Query: 1095 DGNTCAHIAAIQGSVKVIEELMKFDRTGVISA--RNKLNDSTPLQLAAEGGHADVVRVL- 1151
D T AA G ++++ +L+ +S+ K N +TPL +AA GH D+V L
Sbjct: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL 61
Query: 1152 ------VRAGASCT--DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLH 1203
+ G S E G + A+ GH V+ + + ++ TPL
Sbjct: 62 EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLR 121
Query: 1204 IAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLL 1263
A + G E V+ L+ H +A VS G T L ++ Y G++ + + L
Sbjct: 122 AACFDGHLEIVKYLVEH-------KADLEVS------NRHGHTCLMISCYKGHKEIAQYL 168
Query: 1264 LNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTH 1323
L G + S G LH G + I+ +LL A++ D +G T L AS
Sbjct: 169 LEK-GADVNRKS-VKGNTALHDCAESGSLDIMKMLLMYCAKM--EKDGYGMTPLLSASVT 224
Query: 1324 GHYQMVEVL 1332
GH +V+ L
Sbjct: 225 GHTNIVDFL 233
Score = 56.0 bits (129), Expect = 1e-06
Identities = 62/231 (26%), Positives = 106/231 (45%), Gaps = 43/231 (18%)
Query: 732 TPLHIAARIPDGDKCALML------LKSGAGPN--KATEDGMTPVHVAAKFGNLATLVLL 783
TPL +AAR D +L ++ G N T +G P+ A+ G+L + L
Sbjct: 43 TPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSL 102
Query: 784 LEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAV 843
L G T +T TPL+ AC +IV++L+E HK + ++
Sbjct: 103 LNHGASVNNTT-------LTNSTPLRAACFDGHLEIVKYLVE----HKAD------LEVS 145
Query: 844 DEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN 903
+ G + L +C +++ + L+E GADV+ ++ + TA H CA +G+
Sbjct: 146 NRHGHTCLMISCY---------KGHKEIAQYLLEKGADVNRKSVKGN-TALHDCAESGSL 195
Query: 904 DVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
D+M ++ + + + ++ G TPLL A GH +V+ LT+HA+
Sbjct: 196 DIMKMLLMYCAKME-------KDGYGMTPLLSASVTGHTNIVD-FLTHHAQ 238
Score = 52.0 bits (119), Expect = 2e-05
Identities = 37/123 (30%), Positives = 62/123 (50%), Gaps = 2/123 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+GA + A+ GH+ ++ +LL G SV+ TT N T L A +V+ L+ + AD
Sbjct: 82 EGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKAD 141
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ + + T L I+ + A LL+ GA N+ + G T +H A+ G+L +
Sbjct: 142 LEV-SNRHGHTCLMISC-YKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMK 199
Query: 782 LLL 784
+LL
Sbjct: 200 MLL 202
Score = 50.4 bits (115), Expect = 7e-05
Identities = 44/170 (25%), Positives = 76/170 (44%), Gaps = 13/170 (7%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPA---GDTALHLAARRRDVDMARILVDY 120
K + A G ++ +LL++++ E++ + G T L +AAR +DM L++
Sbjct: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ 63
Query: 121 --------GAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLA 171
G+V D G PL A+A G +V+ A+ + TP+ A
Sbjct: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
Query: 172 AENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+GH I++ L + KA + + G T + I+ GH + A L +KG
Sbjct: 124 CFDGHLEIVKYLVEH-KADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKG 172
Score = 42.7 bits (96), Expect = 0.014
Identities = 34/129 (26%), Positives = 58/129 (44%), Gaps = 3/129 (2%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL A G+ +V+ L+ + L+ + G T L ++ + ++A+ L++ GA V+
Sbjct: 119 PLRAACFDGHLEIVKYLVEHKA--DLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVN 176
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ G T LH A G ++K A D TP+ A+ GH I++ L
Sbjct: 177 RKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTH 235
Query: 186 KFKASIFER 194
+ S ER
Sbjct: 236 HAQTSKTER 244
Score = 39.5 bits (88), Expect = 0.13
Identities = 30/108 (27%), Positives = 50/108 (46%), Gaps = 3/108 (2%)
Query: 1327 QMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFA 1386
Q+ +L+ GA++N D + +PLH AA H +++ LL +SGA TNL+
Sbjct: 509 QVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAH-FDATNLHKQTASDL 567
Query: 1387 ASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFV 1434
E ++ + L+ + T R + N + K H +E FV
Sbjct: 568 LDE--KEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGHIPEKLETFV 613
Score = 38.3 bits (85), Expect = 0.29
Identities = 50/175 (28%), Positives = 76/175 (43%), Gaps = 20/175 (11%)
Query: 662 DGARSIHTAARYGHVGIINTLLQK-------GESV--DVTTNDNYTALHIAVESCKPAVV 712
+GA + AARYGH+ ++ LL++ G SV D T + L A + VV
Sbjct: 40 NGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVV 99
Query: 713 ETLLGYGADVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVA 771
++LL +GA V+ TPL A DG + L++ A + G T + ++
Sbjct: 100 QSLLNHGASVN-NTTLTNSTPLRAACF--DGHLEIVKYLVEHKADLEVSNRHGHTCLMIS 156
Query: 772 AKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
G+ LLE G D RK+ V G T L S DI++ L+ +
Sbjct: 157 CYKGHKEIAQYLLEKGADVNRKS-------VKGNTALHDCAESGSLDIMKMLLMY 204
Score = 36.7 bits (81), Expect = 0.89
Identities = 13/42 (30%), Positives = 27/42 (64%)
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
++V +L+E GA+++ D P+H AA NN+ +++ L ++
Sbjct: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIK 549
Score = 35.5 bits (78), Expect = 2.1
Identities = 23/89 (25%), Positives = 46/89 (51%), Gaps = 3/89 (3%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G L+++ G++ + + LL + + + G+TALH A +D+ ++L+ Y
Sbjct: 147 RHGHTCLMISCYKGHKEIAQYLL--EKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMY 204
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKY 149
A ++ +G G TPL A+ G +V +
Sbjct: 205 CAKME-KDGYGMTPLLSASVTGHTNIVDF 232
Score = 35.5 bits (78), Expect = 2.1
Identities = 22/63 (34%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Query: 189 ASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDEVLFVK-IENG 247
A + R D ++ +HIA+LN H D +L K G + N KQT ++L K I
Sbjct: 519 ADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATN--LHKQTASDLLDEKEIAKN 576
Query: 248 LIK 250
LI+
Sbjct: 577 LIQ 579
Score = 33.5 bits (73), Expect = 8.3
Identities = 19/57 (33%), Positives = 30/57 (52%), Gaps = 1/57 (1%)
Query: 975 LQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQT 1031
LQV L+ A +N + + + LH+AA+N + ++ LI+ A D L KQT
Sbjct: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKS-GAHFDATNLHKQT 563
>AY249188-1|AAO64429.1| 617|Homo sapiens FEM1C protein.
Length = 617
Score = 101 bits (243), Expect = 2e-20
Identities = 74/239 (30%), Positives = 117/239 (48%), Gaps = 13/239 (5%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLR-----ISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
TAV AA G +L + ++ + IS K G TPL +AA YG + V LL
Sbjct: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
Query: 1222 PGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYN 1281
+++ + GA PL A+ G+ VV+ LLN G + + N
Sbjct: 65 SASIEVGGSVNFDGETIEGAP----PLWAASAAGHLKVVQSLLNH-GASVNNTTLTNS-T 118
Query: 1282 PLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINA 1341
PL ACF GH+ IV L+ A+L ++RHG T L I+ GH ++ + LL +GA++N
Sbjct: 119 PLRAACFDGHLEIVKYLVEHKADL-EVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNR 177
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
G T LH A++G L+++K+L A + + P+ A+ H +++++L H
Sbjct: 178 KSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKD-GYGMTPLLSASVTGHTNIVDFLTH 235
Score = 90.2 bits (214), Expect = 7e-17
Identities = 69/252 (27%), Positives = 135/252 (53%), Gaps = 22/252 (8%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKA-----FINSKARNGRTALHLAAMNGYAHLVKFLIRD 1017
++A+ AA G L++ LL +K+ + S+ NG T L +AA G+ +V+FL+
Sbjct: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ 63
Query: 1018 HNAMIDV--------LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA 1069
+A I+V T++ PL A+A+G ++V + LL GA+++ T P+ AA
Sbjct: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNK 1129
+ + E+V+ +L +H + + + G+TC I+ +G ++ + L++ G R
Sbjct: 124 CFDGHLEIVK-YLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLE---KGADVNRKS 179
Query: 1130 LNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM----R 1185
+ +T L AE G D++++L+ A +++ G+T + A+ GHTN++D + +
Sbjct: 180 VKGNTALHDCAESGSLDIMKMLLMYCAK-MEKDGYGMTPLLSASVTGHTNIVDFLTHHAQ 238
Query: 1186 STNTLRISSKKL 1197
++ T RI++ +L
Sbjct: 239 TSKTERINALEL 250
Score = 87.8 bits (208), Expect = 4e-16
Identities = 67/249 (26%), Positives = 120/249 (48%), Gaps = 13/249 (5%)
Query: 891 ETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLT 950
+TA A G ++T+++A S +VS ++ + + G TPLL+A GH+ +V LL
Sbjct: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTN-GATPLLMAARYGHLDMVEFLLE 62
Query: 951 N-HARVDV-----FD---VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A ++V FD +EG L A+ G+L+V +LL + A +N+ T L
Sbjct: 63 QCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRA 122
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A +G+ +VK+L+ +H A ++V T L ++ G E+ + LLE GA+++
Sbjct: 123 ACFDGHLEIVKYLV-EHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK 181
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
G +H A++ +++++ L M G T A++ G +++ L +T
Sbjct: 182 GNTALHDCAESGSLDIMKMLLMYCAK--MEKDGYGMTPLLSASVTGHTNIVDFLTHHAQT 239
Query: 1122 GVISARNKL 1130
N L
Sbjct: 240 SKTERINAL 248
Score = 73.3 bits (172), Expect = 8e-12
Identities = 52/205 (25%), Positives = 102/205 (49%), Gaps = 6/205 (2%)
Query: 884 LQTRHNHETAFHYCAIAGNNDVMTEMIAHISTA-DVSRALNRQNSI--GWTPLLIACHRG 940
+ + N T A G+ D++ ++ S + +V ++N G PL A G
Sbjct: 35 ISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAG 94
Query: 941 HMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALH 1000
H+++V +LL + A V+ + + L A G+L++ L+ +KA + R+G T L
Sbjct: 95 HLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLM 154
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDE 1060
++ G+ + ++L+ + A ++ ++K T LH A SG +++ K+LL A ++ D
Sbjct: 155 ISCYKGHKEIAQYLL-EKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDG 212
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQH 1085
G P+ +A+ ++ +V FL H
Sbjct: 213 YGMTPLLSASVTGHTNIVD-FLTHH 236
Score = 72.1 bits (169), Expect = 2e-11
Identities = 75/252 (29%), Positives = 110/252 (43%), Gaps = 20/252 (7%)
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
D T V AA+ G L L LL + I + G TPL MA R D+V
Sbjct: 2 DLKTAVFNAARDGKLRLLTKLLASKSK--EEVSSLISEKTNGATPLLMAARYGHLDMVEF 59
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L+E S F D +GA L A +VV+ L+ +GA V
Sbjct: 60 LLEQCSASIEVGGSVNF-DGETIEGAPPLWAAS---------AAGHLKVVQSLLNHGASV 109
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ T N T G+ +++ ++ H + +VS N G T L+I+C++GH
Sbjct: 110 NNTTLTN-STPLRAACFDGHLEIVKYLVEHKADLEVS------NRHGHTCLMISCYKGHK 162
Query: 943 QLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLA 1002
++ LL A V+ V+G +ALH AE G L + LL A + K G T L A
Sbjct: 163 EIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKM-EKDGYGMTPLLSA 221
Query: 1003 AMNGYAHLVKFL 1014
++ G+ ++V FL
Sbjct: 222 SVTGHTNIVDFL 233
Score = 69.3 bits (162), Expect = 1e-10
Identities = 61/230 (26%), Positives = 107/230 (46%), Gaps = 28/230 (12%)
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRST--------NTLRISSKKL-GLTPLHIAA 1206
+S E G T + +AA +GH ++++ + ++ + + G PL A+
Sbjct: 32 SSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAAS 91
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS 1266
G + V+ LL+H G S+ S TPL A ++G+ +V+ L+
Sbjct: 92 AAGHLKVVQSLLNH-----------GASVNNTTLTNS--TPLRAACFDGHLEIVKYLVEH 138
Query: 1267 AGVQADA-ASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGH 1325
+AD SN +G+ L ++C+ GH I LL + A++ + + G T LH + G
Sbjct: 139 ---KADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK-GNTALHDCAESGS 194
Query: 1326 YQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSE 1375
++++LL A++ D G TPL A+ GH N+V L + K+E
Sbjct: 195 LDIMKMLLMYCAKMEK-DGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTE 243
Score = 68.1 bits (159), Expect = 3e-10
Identities = 54/170 (31%), Positives = 78/170 (45%), Gaps = 11/170 (6%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAG---VQADAASNENGYNPLHLACFGGHMSIVGLLL--- 1299
T + AA +G ++ LL S V + + NG PL +A GH+ +V LL
Sbjct: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
Query: 1300 SRSAELLHSTDRHGKT-----GLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
S S E+ S + G+T L AS GH ++V+ LL GA +N T TPL A
Sbjct: 65 SASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAAC 124
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
GHL +VK L E A + + + + H ++ +YLL K D
Sbjct: 125 FDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGAD 174
Score = 62.5 bits (145), Expect = 2e-08
Identities = 54/166 (32%), Positives = 80/166 (48%), Gaps = 17/166 (10%)
Query: 1297 LLLSRSAE---LLHSTDRHGKTGLHIASTHGHYQMVEVLLGQ-------GAEINATDKN- 1345
LL S+S E L S +G T L +A+ +GH MVE LL Q G +N +
Sbjct: 22 LLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETI 81
Query: 1346 -GWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G PL A+ AGHL VV+ L GAS + T N P+ A + H ++++YL+ EH
Sbjct: 82 EGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLV--EHK 139
Query: 1405 TQSLMDDKRFVYNLMV-CSKNHNNIPIEEFVLVSPAPVDTAAKLSN 1449
+ ++ LM+ C K H I +++L A V+ + N
Sbjct: 140 ADLEVSNRHGHTCLMISCYKGHKE--IAQYLLEKGADVNRKSVKGN 183
Score = 59.7 bits (138), Expect = 1e-07
Identities = 45/175 (25%), Positives = 80/175 (45%), Gaps = 10/175 (5%)
Query: 52 KKLIRDLVFQR--GKVPLLLAVEAGNQSMVRELLSAQTAE-------QLKATTPAGDTAL 102
K+ + L+ ++ G PLL+A G+ MV LL +A T G L
Sbjct: 28 KEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPL 87
Query: 103 HLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADN 162
A+ + + + L+++GA V+ T TPL A +G +VKY +A+ +++
Sbjct: 88 WAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNR 147
Query: 163 EDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
T + ++ GH I + L +K A + ++ G+T +H + +G D ML
Sbjct: 148 HGHTCLMISCYKGHKEIAQYLLEK-GADVNRKSVKGNTALHDCAESGSLDIMKML 201
Score = 58.8 bits (136), Expect = 2e-07
Identities = 66/249 (26%), Positives = 104/249 (41%), Gaps = 28/249 (11%)
Query: 1095 DGNTCAHIAAIQGSVKVIEELMKFDRTGVISA--RNKLNDSTPLQLAAEGGHADVVRVL- 1151
D T AA G ++++ +L+ +S+ K N +TPL +AA GH D+V L
Sbjct: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL 61
Query: 1152 ------VRAGASCT--DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLH 1203
+ G S E G + A+ GH V+ + + ++ TPL
Sbjct: 62 EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLR 121
Query: 1204 IAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLL 1263
A + G E V+ L+ H +A VS G T L ++ Y G++ + + L
Sbjct: 122 AACFDGHLEIVKYLVEH-------KADLEVS------NRHGHTCLMISCYKGHKEIAQYL 168
Query: 1264 LNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTH 1323
L G + S G LH G + I+ +LL A++ D +G T L AS
Sbjct: 169 LEK-GADVNRKS-VKGNTALHDCAESGSLDIMKMLLMYCAKM--EKDGYGMTPLLSASVT 224
Query: 1324 GHYQMVEVL 1332
GH +V+ L
Sbjct: 225 GHTNIVDFL 233
Score = 56.0 bits (129), Expect = 1e-06
Identities = 62/231 (26%), Positives = 106/231 (45%), Gaps = 43/231 (18%)
Query: 732 TPLHIAARIPDGDKCALML------LKSGAGPN--KATEDGMTPVHVAAKFGNLATLVLL 783
TPL +AAR D +L ++ G N T +G P+ A+ G+L + L
Sbjct: 43 TPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSL 102
Query: 784 LEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAV 843
L G T +T TPL+ AC +IV++L+E HK + ++
Sbjct: 103 LNHGASVNNTT-------LTNSTPLRAACFDGHLEIVKYLVE----HKAD------LEVS 145
Query: 844 DEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN 903
+ G + L +C +++ + L+E GADV+ ++ + TA H CA +G+
Sbjct: 146 NRHGHTCLMISCY---------KGHKEIAQYLLEKGADVNRKSVKGN-TALHDCAESGSL 195
Query: 904 DVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
D+M ++ + + + ++ G TPLL A GH +V+ LT+HA+
Sbjct: 196 DIMKMLLMYCAKME-------KDGYGMTPLLSASVTGHTNIVD-FLTHHAQ 238
Score = 52.0 bits (119), Expect = 2e-05
Identities = 37/123 (30%), Positives = 62/123 (50%), Gaps = 2/123 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+GA + A+ GH+ ++ +LL G SV+ TT N T L A +V+ L+ + AD
Sbjct: 82 EGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKAD 141
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ + + T L I+ + A LL+ GA N+ + G T +H A+ G+L +
Sbjct: 142 LEV-SNRHGHTCLMISC-YKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMK 199
Query: 782 LLL 784
+LL
Sbjct: 200 MLL 202
Score = 50.4 bits (115), Expect = 7e-05
Identities = 44/170 (25%), Positives = 76/170 (44%), Gaps = 13/170 (7%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPA---GDTALHLAARRRDVDMARILVDY 120
K + A G ++ +LL++++ E++ + G T L +AAR +DM L++
Sbjct: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ 63
Query: 121 --------GAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLA 171
G+V D G PL A+A G +V+ A+ + TP+ A
Sbjct: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
Query: 172 AENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+GH I++ L + KA + + G T + I+ GH + A L +KG
Sbjct: 124 CFDGHLEIVKYLVEH-KADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKG 172
Score = 42.7 bits (96), Expect = 0.014
Identities = 34/129 (26%), Positives = 58/129 (44%), Gaps = 3/129 (2%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL A G+ +V+ L+ + L+ + G T L ++ + ++A+ L++ GA V+
Sbjct: 119 PLRAACFDGHLEIVKYLVEHKA--DLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVN 176
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ G T LH A G ++K A D TP+ A+ GH I++ L
Sbjct: 177 RKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTH 235
Query: 186 KFKASIFER 194
+ S ER
Sbjct: 236 HAQTSKTER 244
Score = 39.5 bits (88), Expect = 0.13
Identities = 30/108 (27%), Positives = 50/108 (46%), Gaps = 3/108 (2%)
Query: 1327 QMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFA 1386
Q+ +L+ GA++N D + +PLH AA H +++ LL +SGA TNL+
Sbjct: 509 QVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAH-FDATNLHKQTASDL 567
Query: 1387 ASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFV 1434
E ++ + L+ + T R + N + K H +E FV
Sbjct: 568 LDE--KEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGHIPEKLETFV 613
Score = 38.3 bits (85), Expect = 0.29
Identities = 50/175 (28%), Positives = 76/175 (43%), Gaps = 20/175 (11%)
Query: 662 DGARSIHTAARYGHVGIINTLLQK-------GESV--DVTTNDNYTALHIAVESCKPAVV 712
+GA + AARYGH+ ++ LL++ G SV D T + L A + VV
Sbjct: 40 NGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVV 99
Query: 713 ETLLGYGADVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVA 771
++LL +GA V+ TPL A DG + L++ A + G T + ++
Sbjct: 100 QSLLNHGASVN-NTTLTNSTPLRAACF--DGHLEIVKYLVEHKADLEVSNRHGHTCLMIS 156
Query: 772 AKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
G+ LLE G D RK+ V G T L S DI++ L+ +
Sbjct: 157 CYKGHKEIAQYLLEKGADVNRKS-------VKGNTALHDCAESGSLDIMKMLLMY 204
Score = 36.7 bits (81), Expect = 0.89
Identities = 13/42 (30%), Positives = 27/42 (64%)
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
++V +L+E GA+++ D P+H AA NN+ +++ L ++
Sbjct: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIK 549
Score = 35.5 bits (78), Expect = 2.1
Identities = 23/89 (25%), Positives = 46/89 (51%), Gaps = 3/89 (3%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G L+++ G++ + + LL + + + G+TALH A +D+ ++L+ Y
Sbjct: 147 RHGHTCLMISCYKGHKEIAQYLL--EKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMY 204
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKY 149
A ++ +G G TPL A+ G +V +
Sbjct: 205 CAKME-KDGYGMTPLLSASVTGHTNIVDF 232
Score = 35.5 bits (78), Expect = 2.1
Identities = 22/63 (34%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Query: 189 ASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDEVLFVK-IENG 247
A + R D ++ +HIA+LN H D +L K G + N KQT ++L K I
Sbjct: 519 ADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATN--LHKQTASDLLDEKEIAKN 576
Query: 248 LIK 250
LI+
Sbjct: 577 LIQ 579
Score = 33.5 bits (73), Expect = 8.3
Identities = 19/57 (33%), Positives = 30/57 (52%), Gaps = 1/57 (1%)
Query: 975 LQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQT 1031
LQV L+ A +N + + + LH+AA+N + ++ LI+ A D L KQT
Sbjct: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKS-GAHFDATNLHKQT 563
>AL365415-1|CAB96957.1| 271|Homo sapiens similar to (NP_034322.1|)
sex-determination protein homolog Fem1a [Mus musculus
protein.
Length = 271
Score = 101 bits (243), Expect = 2e-20
Identities = 74/239 (30%), Positives = 117/239 (48%), Gaps = 13/239 (5%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLR-----ISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
TAV AA G +L + ++ + IS K G TPL +AA YG + V LL
Sbjct: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
Query: 1222 PGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYN 1281
+++ + GA PL A+ G+ VV+ LLN G + + N
Sbjct: 65 SASIEVGGSVNFDGETIEGAP----PLWAASAAGHLKVVQSLLNH-GASVNNTTLTNS-T 118
Query: 1282 PLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINA 1341
PL ACF GH+ IV L+ A+L ++RHG T L I+ GH ++ + LL +GA++N
Sbjct: 119 PLRAACFDGHLEIVKYLVEHKADL-EVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNR 177
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
G T LH A++G L+++K+L A + + P+ A+ H +++++L H
Sbjct: 178 KSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKD-GYGMTPLLSASVTGHTNIVDFLTH 235
Score = 90.2 bits (214), Expect = 7e-17
Identities = 69/252 (27%), Positives = 135/252 (53%), Gaps = 22/252 (8%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKA-----FINSKARNGRTALHLAAMNGYAHLVKFLIRD 1017
++A+ AA G L++ LL +K+ + S+ NG T L +AA G+ +V+FL+
Sbjct: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ 63
Query: 1018 HNAMIDV--------LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA 1069
+A I+V T++ PL A+A+G ++V + LL GA+++ T P+ AA
Sbjct: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNK 1129
+ + E+V+ +L +H + + + G+TC I+ +G ++ + L++ G R
Sbjct: 124 CFDGHLEIVK-YLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLE---KGADVNRKS 179
Query: 1130 LNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM----R 1185
+ +T L AE G D++++L+ A +++ G+T + A+ GHTN++D + +
Sbjct: 180 VKGNTALHDCAESGSLDIMKMLLMYCAK-MEKDGYGMTPLLSASVTGHTNIVDFLTHHAQ 238
Query: 1186 STNTLRISSKKL 1197
++ T RI++ +L
Sbjct: 239 TSKTERINALEL 250
Score = 87.8 bits (208), Expect = 4e-16
Identities = 67/249 (26%), Positives = 120/249 (48%), Gaps = 13/249 (5%)
Query: 891 ETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLT 950
+TA A G ++T+++A S +VS ++ + + G TPLL+A GH+ +V LL
Sbjct: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTN-GATPLLMAARYGHLDMVEFLLE 62
Query: 951 N-HARVDV-----FD---VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A ++V FD +EG L A+ G+L+V +LL + A +N+ T L
Sbjct: 63 QCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRA 122
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A +G+ +VK+L+ +H A ++V T L ++ G E+ + LLE GA+++
Sbjct: 123 ACFDGHLEIVKYLV-EHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK 181
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
G +H A++ +++++ L M G T A++ G +++ L +T
Sbjct: 182 GNTALHDCAESGSLDIMKMLLMYCAK--MEKDGYGMTPLLSASVTGHTNIVDFLTHHAQT 239
Query: 1122 GVISARNKL 1130
N L
Sbjct: 240 SKTERINAL 248
Score = 73.3 bits (172), Expect = 8e-12
Identities = 52/205 (25%), Positives = 102/205 (49%), Gaps = 6/205 (2%)
Query: 884 LQTRHNHETAFHYCAIAGNNDVMTEMIAHISTA-DVSRALNRQNSI--GWTPLLIACHRG 940
+ + N T A G+ D++ ++ S + +V ++N G PL A G
Sbjct: 35 ISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAG 94
Query: 941 HMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALH 1000
H+++V +LL + A V+ + + L A G+L++ L+ +KA + R+G T L
Sbjct: 95 HLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLM 154
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDE 1060
++ G+ + ++L+ + A ++ ++K T LH A SG +++ K+LL A ++ D
Sbjct: 155 ISCYKGHKEIAQYLL-EKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDG 212
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQH 1085
G P+ +A+ ++ +V FL H
Sbjct: 213 YGMTPLLSASVTGHTNIVD-FLTHH 236
Score = 72.1 bits (169), Expect = 2e-11
Identities = 75/252 (29%), Positives = 110/252 (43%), Gaps = 20/252 (7%)
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
D T V AA+ G L L LL + I + G TPL MA R D+V
Sbjct: 2 DLKTAVFNAARDGKLRLLTKLLASKSK--EEVSSLISEKTNGATPLLMAARYGHLDMVEF 59
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L+E S F D +GA L A +VV+ L+ +GA V
Sbjct: 60 LLEQCSASIEVGGSVNF-DGETIEGAPPLWAAS---------AAGHLKVVQSLLNHGASV 109
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ T N T G+ +++ ++ H + +VS N G T L+I+C++GH
Sbjct: 110 NNTTLTN-STPLRAACFDGHLEIVKYLVEHKADLEVS------NRHGHTCLMISCYKGHK 162
Query: 943 QLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLA 1002
++ LL A V+ V+G +ALH AE G L + LL A + K G T L A
Sbjct: 163 EIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKM-EKDGYGMTPLLSA 221
Query: 1003 AMNGYAHLVKFL 1014
++ G+ ++V FL
Sbjct: 222 SVTGHTNIVDFL 233
Score = 69.3 bits (162), Expect = 1e-10
Identities = 61/230 (26%), Positives = 107/230 (46%), Gaps = 28/230 (12%)
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRST--------NTLRISSKKL-GLTPLHIAA 1206
+S E G T + +AA +GH ++++ + ++ + + G PL A+
Sbjct: 32 SSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAAS 91
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS 1266
G + V+ LL+H G S+ S TPL A ++G+ +V+ L+
Sbjct: 92 AAGHLKVVQSLLNH-----------GASVNNTTLTNS--TPLRAACFDGHLEIVKYLVEH 138
Query: 1267 AGVQADA-ASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGH 1325
+AD SN +G+ L ++C+ GH I LL + A++ + + G T LH + G
Sbjct: 139 ---KADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK-GNTALHDCAESGS 194
Query: 1326 YQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSE 1375
++++LL A++ D G TPL A+ GH N+V L + K+E
Sbjct: 195 LDIMKMLLMYCAKMEK-DGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTE 243
Score = 68.1 bits (159), Expect = 3e-10
Identities = 54/170 (31%), Positives = 78/170 (45%), Gaps = 11/170 (6%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAG---VQADAASNENGYNPLHLACFGGHMSIVGLLL--- 1299
T + AA +G ++ LL S V + + NG PL +A GH+ +V LL
Sbjct: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
Query: 1300 SRSAELLHSTDRHGKT-----GLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
S S E+ S + G+T L AS GH ++V+ LL GA +N T TPL A
Sbjct: 65 SASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAAC 124
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
GHL +VK L E A + + + + H ++ +YLL K D
Sbjct: 125 FDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGAD 174
Score = 62.5 bits (145), Expect = 2e-08
Identities = 54/166 (32%), Positives = 80/166 (48%), Gaps = 17/166 (10%)
Query: 1297 LLLSRSAE---LLHSTDRHGKTGLHIASTHGHYQMVEVLLGQ-------GAEINATDKN- 1345
LL S+S E L S +G T L +A+ +GH MVE LL Q G +N +
Sbjct: 22 LLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETI 81
Query: 1346 -GWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G PL A+ AGHL VV+ L GAS + T N P+ A + H ++++YL+ EH
Sbjct: 82 EGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLV--EHK 139
Query: 1405 TQSLMDDKRFVYNLMV-CSKNHNNIPIEEFVLVSPAPVDTAAKLSN 1449
+ ++ LM+ C K H I +++L A V+ + N
Sbjct: 140 ADLEVSNRHGHTCLMISCYKGHKE--IAQYLLEKGADVNRKSVKGN 183
Score = 59.7 bits (138), Expect = 1e-07
Identities = 45/175 (25%), Positives = 80/175 (45%), Gaps = 10/175 (5%)
Query: 52 KKLIRDLVFQR--GKVPLLLAVEAGNQSMVRELLSAQTAE-------QLKATTPAGDTAL 102
K+ + L+ ++ G PLL+A G+ MV LL +A T G L
Sbjct: 28 KEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPL 87
Query: 103 HLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADN 162
A+ + + + L+++GA V+ T TPL A +G +VKY +A+ +++
Sbjct: 88 WAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNR 147
Query: 163 EDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
T + ++ GH I + L +K A + ++ G+T +H + +G D ML
Sbjct: 148 HGHTCLMISCYKGHKEIAQYLLEK-GADVNRKSVKGNTALHDCAESGSLDIMKML 201
Score = 58.8 bits (136), Expect = 2e-07
Identities = 66/249 (26%), Positives = 104/249 (41%), Gaps = 28/249 (11%)
Query: 1095 DGNTCAHIAAIQGSVKVIEELMKFDRTGVISA--RNKLNDSTPLQLAAEGGHADVVRVL- 1151
D T AA G ++++ +L+ +S+ K N +TPL +AA GH D+V L
Sbjct: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL 61
Query: 1152 ------VRAGASCT--DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLH 1203
+ G S E G + A+ GH V+ + + ++ TPL
Sbjct: 62 EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLR 121
Query: 1204 IAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLL 1263
A + G E V+ L+ H +A VS G T L ++ Y G++ + + L
Sbjct: 122 AACFDGHLEIVKYLVEH-------KADLEVS------NRHGHTCLMISCYKGHKEIAQYL 168
Query: 1264 LNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTH 1323
L G + S G LH G + I+ +LL A++ D +G T L AS
Sbjct: 169 LEK-GADVNRKS-VKGNTALHDCAESGSLDIMKMLLMYCAKM--EKDGYGMTPLLSASVT 224
Query: 1324 GHYQMVEVL 1332
GH +V+ L
Sbjct: 225 GHTNIVDFL 233
Score = 56.0 bits (129), Expect = 1e-06
Identities = 62/231 (26%), Positives = 106/231 (45%), Gaps = 43/231 (18%)
Query: 732 TPLHIAARIPDGDKCALML------LKSGAGPN--KATEDGMTPVHVAAKFGNLATLVLL 783
TPL +AAR D +L ++ G N T +G P+ A+ G+L + L
Sbjct: 43 TPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSL 102
Query: 784 LEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAV 843
L G T +T TPL+ AC +IV++L+E HK + ++
Sbjct: 103 LNHGASVNNTT-------LTNSTPLRAACFDGHLEIVKYLVE----HKAD------LEVS 145
Query: 844 DEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN 903
+ G + L +C +++ + L+E GADV+ ++ + TA H CA +G+
Sbjct: 146 NRHGHTCLMISCY---------KGHKEIAQYLLEKGADVNRKSVKGN-TALHDCAESGSL 195
Query: 904 DVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
D+M ++ + + + ++ G TPLL A GH +V+ LT+HA+
Sbjct: 196 DIMKMLLMYCAKME-------KDGYGMTPLLSASVTGHTNIVD-FLTHHAQ 238
Score = 52.0 bits (119), Expect = 2e-05
Identities = 37/123 (30%), Positives = 62/123 (50%), Gaps = 2/123 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+GA + A+ GH+ ++ +LL G SV+ TT N T L A +V+ L+ + AD
Sbjct: 82 EGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKAD 141
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ + + T L I+ + A LL+ GA N+ + G T +H A+ G+L +
Sbjct: 142 LEV-SNRHGHTCLMISC-YKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMK 199
Query: 782 LLL 784
+LL
Sbjct: 200 MLL 202
Score = 50.4 bits (115), Expect = 7e-05
Identities = 44/170 (25%), Positives = 76/170 (44%), Gaps = 13/170 (7%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPA---GDTALHLAARRRDVDMARILVDY 120
K + A G ++ +LL++++ E++ + G T L +AAR +DM L++
Sbjct: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ 63
Query: 121 --------GAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLA 171
G+V D G PL A+A G +V+ A+ + TP+ A
Sbjct: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
Query: 172 AENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+GH I++ L + KA + + G T + I+ GH + A L +KG
Sbjct: 124 CFDGHLEIVKYLVEH-KADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKG 172
Score = 42.7 bits (96), Expect = 0.014
Identities = 34/129 (26%), Positives = 58/129 (44%), Gaps = 3/129 (2%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL A G+ +V+ L+ + L+ + G T L ++ + ++A+ L++ GA V+
Sbjct: 119 PLRAACFDGHLEIVKYLVEHKA--DLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVN 176
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ G T LH A G ++K A D TP+ A+ GH I++ L
Sbjct: 177 RKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTH 235
Query: 186 KFKASIFER 194
+ S ER
Sbjct: 236 HAQTSKTER 244
Score = 38.3 bits (85), Expect = 0.29
Identities = 50/175 (28%), Positives = 76/175 (43%), Gaps = 20/175 (11%)
Query: 662 DGARSIHTAARYGHVGIINTLLQK-------GESV--DVTTNDNYTALHIAVESCKPAVV 712
+GA + AARYGH+ ++ LL++ G SV D T + L A + VV
Sbjct: 40 NGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVV 99
Query: 713 ETLLGYGADVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVA 771
++LL +GA V+ TPL A DG + L++ A + G T + ++
Sbjct: 100 QSLLNHGASVN-NTTLTNSTPLRAACF--DGHLEIVKYLVEHKADLEVSNRHGHTCLMIS 156
Query: 772 AKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
G+ LLE G D RK+ V G T L S DI++ L+ +
Sbjct: 157 CYKGHKEIAQYLLEKGADVNRKS-------VKGNTALHDCAESGSLDIMKMLLMY 204
Score = 35.5 bits (78), Expect = 2.1
Identities = 23/89 (25%), Positives = 46/89 (51%), Gaps = 3/89 (3%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G L+++ G++ + + LL + + + G+TALH A +D+ ++L+ Y
Sbjct: 147 RHGHTCLMISCYKGHKEIAQYLL--EKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMY 204
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKY 149
A ++ +G G TPL A+ G +V +
Sbjct: 205 CAKME-KDGYGMTPLLSASVTGHTNIVDF 232
>AJ278120-1|CAB92314.1| 1101|Homo sapiens putative ankyrin-repeat
containing protein protein.
Length = 1101
Score = 101 bits (243), Expect = 2e-20
Identities = 92/293 (31%), Positives = 135/293 (46%), Gaps = 20/293 (6%)
Query: 944 LVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAA 1003
+V LL A VD G + L AA GYL + L +A ++ +NG+ AL AA
Sbjct: 1 MVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAA 60
Query: 1004 MNGYAHLVKFLIRDHNAMIDVL--TLKK----QTPLHLAAASGQIEVCKLLLELG----- 1052
+ G+ +VKFLI+ M KK Q L AA+ G E+ LL+L
Sbjct: 61 LRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEE 120
Query: 1053 ----ANIDATDEL-GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQG 1107
A I++ D L G+ + AAA EV +L L+Q V + G QG
Sbjct: 121 EVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGA-AVAQPNRRGAVPLFSTVRQG 179
Query: 1108 SVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLT 1167
++++ L+ ++ +K TPL +AA GH V L+ GAS ++ GLT
Sbjct: 180 HWQIVDLLLTHGAD--VNMADK-QGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLT 236
Query: 1168 AVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSH 1220
A+ A GH +V+ + + K G TPL +AA+YG AE V+ L+ H
Sbjct: 237 ALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDH 289
Score = 97.5 bits (232), Expect = 5e-19
Identities = 85/273 (31%), Positives = 122/273 (44%), Gaps = 13/273 (4%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
TPL AA G+ +V +L + A ++ G A+ AA GH V+ + +
Sbjct: 21 TPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAG 80
Query: 1194 SKKLGLTPLHI-------AAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLT 1246
++ H AA G E V LL +P K E + + + G T
Sbjct: 81 QQQGVFKKSHAIQQALIAAASMGYTEIVSYLLD-LPE--KDEEEVERAQINSFDSLWGET 137
Query: 1247 PLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELL 1306
L AA G V RLLL A A N G PL GH IV LLL+ A++
Sbjct: 138 ALTAAAGRGKLEVCRLLLEQGA--AVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADV- 194
Query: 1307 HSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
+ D+ G+T L +A++ GH V+ LL QGA I DK G T L A GHL+VV+ L
Sbjct: 195 NMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLV 254
Query: 1367 ESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
++GA+ P+ AA +V+++L+
Sbjct: 255 DNGAATDHADKNGRTPLDLAAFYGDAEVVQFLV 287
Score = 84.6 bits (200), Expect = 3e-15
Identities = 100/356 (28%), Positives = 159/356 (44%), Gaps = 22/356 (6%)
Query: 711 VVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHV 770
+V LL +GA+V + TPL AA ++L K A + ++G +
Sbjct: 1 MVALLLEFGANVDA-SSESGLTPLGYAAAA-GYLSIVVLLCKKRAKVDHLDKNGQCALVH 58
Query: 771 AAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDH 830
AA G+L + L++ + + + L A +IV +L++ +
Sbjct: 59 AALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKD 118
Query: 831 KGESVSTAFIDAVDED-GASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHN 889
+ E V A I++ D G +AL A K EV + L+E GA V+ R
Sbjct: 119 E-EEVERAQINSFDSLWGETALTAAAGRGKLEV---------CRLLLEQGAAVAQPNRRG 168
Query: 890 HETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLL 949
F G+ ++ ++ H ADV+ A ++Q G TPL++A GH+ V+ LL
Sbjct: 169 AVPLFSTVR-QGHWQIVDLLLTH--GADVNMA-DKQ---GRTPLMMAASEGHLGTVDFLL 221
Query: 950 TNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAH 1009
A + + D EG +AL A G+L V +L+ N A + +NGRT L LAA G A
Sbjct: 222 AQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAE 281
Query: 1010 LVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKP 1065
+V+FL+ DH AMI+ + PL A V LL+ + D ++ +P
Sbjct: 282 VVQFLV-DHGAMIEHVDYSGMRPLDRAVGCPNTSVVVTLLKKRSQ-DRLSDVXSRP 335
Score = 78.6 bits (185), Expect = 2e-13
Identities = 88/340 (25%), Positives = 142/340 (41%), Gaps = 35/340 (10%)
Query: 981 LLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASG 1040
LL A +++ + +G T L AA GY +V L + A +D L Q L AA G
Sbjct: 5 LLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKR-AKVDHLDKNGQCALVHAALRG 63
Query: 1041 QIEVCKLLLELGANIDATDELGQKPIHA-------AAQNNYSEVVQLFL------QQHPN 1087
+EV K L++ + + K HA AA Y+E+V L ++
Sbjct: 64 HLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVE 123
Query: 1088 LVMATTKD---GNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
+ D G T AA +G ++V L++ G A+ + PL GH
Sbjct: 124 RAQINSFDSLWGETALTAAAGRGKLEVCRLLLE---QGAAVAQPNRRGAVPLFSTVRQGH 180
Query: 1145 ADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHI 1204
+V +L+ GA ++ G T + +AA GH +D + + K GLT L
Sbjct: 181 WQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSW 240
Query: 1205 AAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLL 1264
A G VR L+ + T ++ ++G TPL LAA+ G+ VV+ L+
Sbjct: 241 ACLKGHLSVVRSLVDNGAATDHAD-------------KNGRTPLDLAAFYGDAEVVQFLV 287
Query: 1265 NSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAE 1304
+ + + +G PL A + S+V LL + ++
Sbjct: 288 DHGAMIEHV--DYSGMRPLDRAVGCPNTSVVVTLLKKRSQ 325
Score = 72.5 bits (170), Expect = 1e-11
Identities = 92/342 (26%), Positives = 137/342 (40%), Gaps = 37/342 (10%)
Query: 1077 VVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPL 1136
+V L L+ N V A+++ G T AA G + ++ L K + + +K N L
Sbjct: 1 MVALLLEFGAN-VDASSESGLTPLGYAAAAGYLSIVVLLCK--KRAKVDHLDK-NGQCAL 56
Query: 1137 QLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHL-------AAEHGHTNVLDVM----- 1184
AA GH +VV+ L++ + + + H AA G+T ++ +
Sbjct: 57 VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE 116
Query: 1185 ---RSTNTLRISS--KKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVL 1239
+I+S G T L AA G+ E R LL +
Sbjct: 117 KDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPN----------- 165
Query: 1240 GAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLL 1299
G PL G+ +V LLL G + A + G PL +A GH+ V LL
Sbjct: 166 --RRGAVPLFSTVRQGHWQIVDLLLTH-GADVNMADKQ-GRTPLMMAASEGHLGTVDFLL 221
Query: 1300 SRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHL 1359
++ A + D+ G T L A GH +V L+ GA + DKNG TPL AA G
Sbjct: 222 AQGASIA-LMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDA 280
Query: 1360 NVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
VV+ L + GA + P+ A + V+ LL K
Sbjct: 281 EVVQFLVDHGAMIEHVDYSGMRPLDRAVGCPNTSVVVTLLKK 322
Score = 67.7 bits (158), Expect = 4e-10
Identities = 41/124 (33%), Positives = 60/124 (48%), Gaps = 1/124 (0%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G+TAL AA R +++ R+L++ GA V N G PL +G +V A+
Sbjct: 135 GETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADV 194
Query: 158 AIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
+AD + RTP+ +AA GH ++ L + ASI K+G T + A L GH L
Sbjct: 195 NMADKQGRTPLMMAASEGHLGTVDFLLAQ-GASIALMDKEGLTALSWACLKGHLSVVRSL 253
Query: 218 FKKG 221
G
Sbjct: 254 VDNG 257
Score = 58.0 bits (134), Expect = 3e-07
Identities = 43/162 (26%), Positives = 70/162 (43%), Gaps = 3/162 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ L A G + R LL A + G L R+ + +L+ +GA
Sbjct: 135 GETALTAAAGRGKLEVCRLLLEQGAA--VAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGA 192
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+ + G+TPL +AA+EG V + A+ A+ D E T + A GH +++
Sbjct: 193 DVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRS 252
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
L D A+ K+G T + +A+ G A+ L G +
Sbjct: 253 LVDN-GAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMI 293
Score = 52.0 bits (119), Expect = 2e-05
Identities = 37/126 (29%), Positives = 59/126 (46%), Gaps = 2/126 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++G+ PL++A G+ V + L AQ A + G TAL A + + + R LVD
Sbjct: 199 KQGRTPLMMAASEGHLGTV-DFLLAQGAS-IALMDKEGLTALSWACLKGHLSVVRSLVDN 256
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA D + G+TPL +AA GD +V++ A D P+ A + +++
Sbjct: 257 GAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCPNTSVV 316
Query: 181 ELLADK 186
L K
Sbjct: 317 VTLLKK 322
Score = 49.2 bits (112), Expect = 2e-04
Identities = 38/125 (30%), Positives = 56/125 (44%), Gaps = 2/125 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+RG VPL V G+ +V +LL A+ + G T L +AA + L+
Sbjct: 166 RRGAVPLFSTVRQGHWQIV-DLLLTHGAD-VNMADKQGRTPLMMAASEGHLGTVDFLLAQ 223
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA + + G T L A +G +V+ A AD RTP+ LAA G A ++
Sbjct: 224 GASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVV 283
Query: 181 ELLAD 185
+ L D
Sbjct: 284 QFLVD 288
Score = 46.8 bits (106), Expect = 8e-04
Identities = 37/123 (30%), Positives = 55/123 (44%), Gaps = 2/123 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G + AA GH+G ++ LL +G S+ + + TAL A +VV +L+ GA
Sbjct: 201 GRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAAT 260
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
K TPL +AA D + L+ GA GM P+ A N + +V
Sbjct: 261 D-HADKNGRTPLDLAAFYGDAE-VVQFLVDHGAMIEHVDYSGMRPLDRAVGCPNTSVVVT 318
Query: 783 LLE 785
LL+
Sbjct: 319 LLK 321
Score = 46.0 bits (104), Expect = 0.001
Identities = 44/164 (26%), Positives = 75/164 (45%), Gaps = 11/164 (6%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA G + + LL++G +V L V +V+ LL +GADV
Sbjct: 135 GETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADV 194
Query: 723 HIRGGKQRETPLHIAARIPDGDKCAL-MLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
++ KQ TPL +AA +G + LL GA ++G+T + A G+L+ +
Sbjct: 195 NM-ADKQGRTPLMMAA--SEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVR 251
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIE 825
L+++G K G TPL +A ++V+ L++
Sbjct: 252 SLVDNGAATDHADK-------NGRTPLDLAAFYGDAEVVQFLVD 288
Score = 41.5 bits (93), Expect = 0.031
Identities = 24/71 (33%), Positives = 37/71 (52%)
Query: 113 MARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA 172
M +L+++GA VDA++ +G TPL AAA G +V RA D + + AA
Sbjct: 1 MVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAA 60
Query: 173 ENGHAAIIELL 183
GH +++ L
Sbjct: 61 LRGHLEVVKFL 71
Score = 37.1 bits (82), Expect = 0.67
Identities = 30/108 (27%), Positives = 49/108 (45%), Gaps = 2/108 (1%)
Query: 58 LVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARIL 117
L+ + G L A G+ S+VR L+ A G T L LAA D ++ + L
Sbjct: 229 LMDKEGLTALSWACLKGHLSVVRSLVDNGAATD--HADKNGRTPLDLAAFYGDAEVVQFL 286
Query: 118 VDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR 165
VD+GA+++ + +G PL A + +V R+ ++D R
Sbjct: 287 VDHGAMIEHVDYSGMRPLDRAVGCPNTSVVVTLLKKRSQDRLSDVXSR 334
>AF391093-1|AAL37627.1| 617|Homo sapiens FEM1A protein.
Length = 617
Score = 101 bits (243), Expect = 2e-20
Identities = 74/239 (30%), Positives = 117/239 (48%), Gaps = 13/239 (5%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLR-----ISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
TAV AA G +L + ++ + IS K G TPL +AA YG + V LL
Sbjct: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
Query: 1222 PGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYN 1281
+++ + GA PL A+ G+ VV+ LLN G + + N
Sbjct: 65 SASIEVGGSVNFDGETIEGAP----PLWAASAAGHLKVVQSLLNH-GASVNNTTLTNS-T 118
Query: 1282 PLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINA 1341
PL ACF GH+ IV L+ A+L ++RHG T L I+ GH ++ + LL +GA++N
Sbjct: 119 PLRAACFDGHLEIVKYLVEHKADL-EVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNR 177
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
G T LH A++G L+++K+L A + + P+ A+ H +++++L H
Sbjct: 178 KSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKD-GYGMTPLLSASVTGHTNIVDFLTH 235
Score = 90.2 bits (214), Expect = 7e-17
Identities = 69/252 (27%), Positives = 135/252 (53%), Gaps = 22/252 (8%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKA-----FINSKARNGRTALHLAAMNGYAHLVKFLIRD 1017
++A+ AA G L++ LL +K+ + S+ NG T L +AA G+ +V+FL+
Sbjct: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ 63
Query: 1018 HNAMIDV--------LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA 1069
+A I+V T++ PL A+A+G ++V + LL GA+++ T P+ AA
Sbjct: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNK 1129
+ + E+V+ +L +H + + + G+TC I+ +G ++ + L++ G R
Sbjct: 124 CFDGHLEIVK-YLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLE---KGADVNRKS 179
Query: 1130 LNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM----R 1185
+ +T L AE G D++++L+ A +++ G+T + A+ GHTN++D + +
Sbjct: 180 VKGNTALHDCAESGSLDIMKMLLMYCAK-MEKDGYGMTPLLSASVTGHTNIVDFLTHHAQ 238
Query: 1186 STNTLRISSKKL 1197
++ T RI++ +L
Sbjct: 239 TSKTERINALEL 250
Score = 87.8 bits (208), Expect = 4e-16
Identities = 67/249 (26%), Positives = 120/249 (48%), Gaps = 13/249 (5%)
Query: 891 ETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLT 950
+TA A G ++T+++A S +VS ++ + + G TPLL+A GH+ +V LL
Sbjct: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTN-GATPLLMAARYGHLDMVEFLLE 62
Query: 951 N-HARVDV-----FD---VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A ++V FD +EG L A+ G+L+V +LL + A +N+ T L
Sbjct: 63 QCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRA 122
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A +G+ +VK+L+ +H A ++V T L ++ G E+ + LLE GA+++
Sbjct: 123 ACFDGHLEIVKYLV-EHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK 181
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
G +H A++ +++++ L M G T A++ G +++ L +T
Sbjct: 182 GNTALHDCAESGSLDIMKMLLMYCAK--MEKDGYGMTPLLSASVTGHTNIVDFLTHHAQT 239
Query: 1122 GVISARNKL 1130
N L
Sbjct: 240 SKTERINAL 248
Score = 73.3 bits (172), Expect = 8e-12
Identities = 52/205 (25%), Positives = 102/205 (49%), Gaps = 6/205 (2%)
Query: 884 LQTRHNHETAFHYCAIAGNNDVMTEMIAHISTA-DVSRALNRQNSI--GWTPLLIACHRG 940
+ + N T A G+ D++ ++ S + +V ++N G PL A G
Sbjct: 35 ISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAG 94
Query: 941 HMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALH 1000
H+++V +LL + A V+ + + L A G+L++ L+ +KA + R+G T L
Sbjct: 95 HLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLM 154
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDE 1060
++ G+ + ++L+ + A ++ ++K T LH A SG +++ K+LL A ++ D
Sbjct: 155 ISCYKGHKEIAQYLL-EKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDG 212
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQH 1085
G P+ +A+ ++ +V FL H
Sbjct: 213 YGMTPLLSASVTGHTNIVD-FLTHH 236
Score = 72.1 bits (169), Expect = 2e-11
Identities = 75/252 (29%), Positives = 110/252 (43%), Gaps = 20/252 (7%)
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
D T V AA+ G L L LL + I + G TPL MA R D+V
Sbjct: 2 DLKTAVFNAARDGKLRLLTKLLASKSK--EEVSSLISEKTNGATPLLMAARYGHLDMVEF 59
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L+E S F D +GA L A +VV+ L+ +GA V
Sbjct: 60 LLEQCSASIEVGGSVNF-DGETIEGAPPLWAAS---------AAGHLKVVQSLLNHGASV 109
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ T N T G+ +++ ++ H + +VS N G T L+I+C++GH
Sbjct: 110 NNTTLTN-STPLRAACFDGHLEIVKYLVEHKADLEVS------NRHGHTCLMISCYKGHK 162
Query: 943 QLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLA 1002
++ LL A V+ V+G +ALH AE G L + LL A + K G T L A
Sbjct: 163 EIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKM-EKDGYGMTPLLSA 221
Query: 1003 AMNGYAHLVKFL 1014
++ G+ ++V FL
Sbjct: 222 SVTGHTNIVDFL 233
Score = 69.3 bits (162), Expect = 1e-10
Identities = 61/230 (26%), Positives = 107/230 (46%), Gaps = 28/230 (12%)
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRST--------NTLRISSKKL-GLTPLHIAA 1206
+S E G T + +AA +GH ++++ + ++ + + G PL A+
Sbjct: 32 SSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAAS 91
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS 1266
G + V+ LL+H G S+ S TPL A ++G+ +V+ L+
Sbjct: 92 AAGHLKVVQSLLNH-----------GASVNNTTLTNS--TPLRAACFDGHLEIVKYLVEH 138
Query: 1267 AGVQADA-ASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGH 1325
+AD SN +G+ L ++C+ GH I LL + A++ + + G T LH + G
Sbjct: 139 ---KADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK-GNTALHDCAESGS 194
Query: 1326 YQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSE 1375
++++LL A++ D G TPL A+ GH N+V L + K+E
Sbjct: 195 LDIMKMLLMYCAKMEK-DGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTE 243
Score = 68.1 bits (159), Expect = 3e-10
Identities = 54/170 (31%), Positives = 78/170 (45%), Gaps = 11/170 (6%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAG---VQADAASNENGYNPLHLACFGGHMSIVGLLL--- 1299
T + AA +G ++ LL S V + + NG PL +A GH+ +V LL
Sbjct: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
Query: 1300 SRSAELLHSTDRHGKT-----GLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
S S E+ S + G+T L AS GH ++V+ LL GA +N T TPL A
Sbjct: 65 SASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAAC 124
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
GHL +VK L E A + + + + H ++ +YLL K D
Sbjct: 125 FDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGAD 174
Score = 62.5 bits (145), Expect = 2e-08
Identities = 54/166 (32%), Positives = 80/166 (48%), Gaps = 17/166 (10%)
Query: 1297 LLLSRSAE---LLHSTDRHGKTGLHIASTHGHYQMVEVLLGQ-------GAEINATDKN- 1345
LL S+S E L S +G T L +A+ +GH MVE LL Q G +N +
Sbjct: 22 LLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETI 81
Query: 1346 -GWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G PL A+ AGHL VV+ L GAS + T N P+ A + H ++++YL+ EH
Sbjct: 82 EGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLV--EHK 139
Query: 1405 TQSLMDDKRFVYNLMV-CSKNHNNIPIEEFVLVSPAPVDTAAKLSN 1449
+ ++ LM+ C K H I +++L A V+ + N
Sbjct: 140 ADLEVSNRHGHTCLMISCYKGHKE--IAQYLLEKGADVNRKSVKGN 183
Score = 59.7 bits (138), Expect = 1e-07
Identities = 45/175 (25%), Positives = 80/175 (45%), Gaps = 10/175 (5%)
Query: 52 KKLIRDLVFQR--GKVPLLLAVEAGNQSMVRELLSAQTAE-------QLKATTPAGDTAL 102
K+ + L+ ++ G PLL+A G+ MV LL +A T G L
Sbjct: 28 KEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPL 87
Query: 103 HLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADN 162
A+ + + + L+++GA V+ T TPL A +G +VKY +A+ +++
Sbjct: 88 WAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNR 147
Query: 163 EDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
T + ++ GH I + L +K A + ++ G+T +H + +G D ML
Sbjct: 148 HGHTCLMISCYKGHKEIAQYLLEK-GADVNRKSVKGNTALHDCAESGSLDIMKML 201
Score = 58.8 bits (136), Expect = 2e-07
Identities = 66/249 (26%), Positives = 104/249 (41%), Gaps = 28/249 (11%)
Query: 1095 DGNTCAHIAAIQGSVKVIEELMKFDRTGVISA--RNKLNDSTPLQLAAEGGHADVVRVL- 1151
D T AA G ++++ +L+ +S+ K N +TPL +AA GH D+V L
Sbjct: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL 61
Query: 1152 ------VRAGASCT--DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLH 1203
+ G S E G + A+ GH V+ + + ++ TPL
Sbjct: 62 EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLR 121
Query: 1204 IAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLL 1263
A + G E V+ L+ H +A VS G T L ++ Y G++ + + L
Sbjct: 122 AACFDGHLEIVKYLVEH-------KADLEVS------NRHGHTCLMISCYKGHKEIAQYL 168
Query: 1264 LNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTH 1323
L G + S G LH G + I+ +LL A++ D +G T L AS
Sbjct: 169 LEK-GADVNRKS-VKGNTALHDCAESGSLDIMKMLLMYCAKM--EKDGYGMTPLLSASVT 224
Query: 1324 GHYQMVEVL 1332
GH +V+ L
Sbjct: 225 GHTNIVDFL 233
Score = 56.0 bits (129), Expect = 1e-06
Identities = 62/231 (26%), Positives = 106/231 (45%), Gaps = 43/231 (18%)
Query: 732 TPLHIAARIPDGDKCALML------LKSGAGPN--KATEDGMTPVHVAAKFGNLATLVLL 783
TPL +AAR D +L ++ G N T +G P+ A+ G+L + L
Sbjct: 43 TPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSL 102
Query: 784 LEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAV 843
L G T +T TPL+ AC +IV++L+E HK + ++
Sbjct: 103 LNHGASVNNTT-------LTNSTPLRAACFDGHLEIVKYLVE----HKAD------LEVS 145
Query: 844 DEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN 903
+ G + L +C +++ + L+E GADV+ ++ + TA H CA +G+
Sbjct: 146 NRHGHTCLMISCY---------KGHKEIAQYLLEKGADVNRKSVKGN-TALHDCAESGSL 195
Query: 904 DVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
D+M ++ + + + ++ G TPLL A GH +V+ LT+HA+
Sbjct: 196 DIMKMLLMYCAKME-------KDGYGMTPLLSASVTGHTNIVD-FLTHHAQ 238
Score = 52.0 bits (119), Expect = 2e-05
Identities = 37/123 (30%), Positives = 62/123 (50%), Gaps = 2/123 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+GA + A+ GH+ ++ +LL G SV+ TT N T L A +V+ L+ + AD
Sbjct: 82 EGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKAD 141
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ + + T L I+ + A LL+ GA N+ + G T +H A+ G+L +
Sbjct: 142 LEV-SNRHGHTCLMISC-YKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMK 199
Query: 782 LLL 784
+LL
Sbjct: 200 MLL 202
Score = 50.4 bits (115), Expect = 7e-05
Identities = 44/170 (25%), Positives = 76/170 (44%), Gaps = 13/170 (7%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPA---GDTALHLAARRRDVDMARILVDY 120
K + A G ++ +LL++++ E++ + G T L +AAR +DM L++
Sbjct: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ 63
Query: 121 --------GAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLA 171
G+V D G PL A+A G +V+ A+ + TP+ A
Sbjct: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
Query: 172 AENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+GH I++ L + KA + + G T + I+ GH + A L +KG
Sbjct: 124 CFDGHLEIVKYLVEH-KADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKG 172
Score = 42.7 bits (96), Expect = 0.014
Identities = 34/129 (26%), Positives = 58/129 (44%), Gaps = 3/129 (2%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL A G+ +V+ L+ + L+ + G T L ++ + ++A+ L++ GA V+
Sbjct: 119 PLRAACFDGHLEIVKYLVEHKA--DLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVN 176
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ G T LH A G ++K A D TP+ A+ GH I++ L
Sbjct: 177 RKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTH 235
Query: 186 KFKASIFER 194
+ S ER
Sbjct: 236 HAQTSKTER 244
Score = 39.5 bits (88), Expect = 0.13
Identities = 30/108 (27%), Positives = 50/108 (46%), Gaps = 3/108 (2%)
Query: 1327 QMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFA 1386
Q+ +L+ GA++N D + +PLH AA H +++ LL +SGA TNL+
Sbjct: 509 QVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAH-FDATNLHKQTASDL 567
Query: 1387 ASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFV 1434
E ++ + L+ + T R + N + K H +E FV
Sbjct: 568 LDE--KEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGHIPEKLETFV 613
Score = 38.3 bits (85), Expect = 0.29
Identities = 50/175 (28%), Positives = 76/175 (43%), Gaps = 20/175 (11%)
Query: 662 DGARSIHTAARYGHVGIINTLLQK-------GESV--DVTTNDNYTALHIAVESCKPAVV 712
+GA + AARYGH+ ++ LL++ G SV D T + L A + VV
Sbjct: 40 NGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVV 99
Query: 713 ETLLGYGADVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVA 771
++LL +GA V+ TPL A DG + L++ A + G T + ++
Sbjct: 100 QSLLNHGASVN-NTTLTNSTPLRAACF--DGHLEIVKYLVEHKADLEVSNRHGHTCLMIS 156
Query: 772 AKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
G+ LLE G D RK+ V G T L S DI++ L+ +
Sbjct: 157 CYKGHKEIAQYLLEKGADVNRKS-------VKGNTALHDCAESGSLDIMKMLLMY 204
Score = 36.7 bits (81), Expect = 0.89
Identities = 13/42 (30%), Positives = 27/42 (64%)
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
++V +L+E GA+++ D P+H AA NN+ +++ L ++
Sbjct: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIK 549
Score = 35.5 bits (78), Expect = 2.1
Identities = 23/89 (25%), Positives = 46/89 (51%), Gaps = 3/89 (3%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G L+++ G++ + + LL + + + G+TALH A +D+ ++L+ Y
Sbjct: 147 RHGHTCLMISCYKGHKEIAQYLL--EKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMY 204
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKY 149
A ++ +G G TPL A+ G +V +
Sbjct: 205 CAKME-KDGYGMTPLLSASVTGHTNIVDF 232
Score = 35.5 bits (78), Expect = 2.1
Identities = 22/63 (34%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Query: 189 ASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDEVLFVK-IENG 247
A + R D ++ +HIA+LN H D +L K G + N KQT ++L K I
Sbjct: 519 ADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATN--LHKQTASDLLDEKEIAKN 576
Query: 248 LIK 250
LI+
Sbjct: 577 LIQ 579
Score = 33.5 bits (73), Expect = 8.3
Identities = 19/57 (33%), Positives = 30/57 (52%), Gaps = 1/57 (1%)
Query: 975 LQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQT 1031
LQV L+ A +N + + + LH+AA+N + ++ LI+ A D L KQT
Sbjct: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKS-GAHFDATNLHKQT 563
>AB058688-1|BAB47414.1| 617|Homo sapiens KIAA1785 protein protein.
Length = 617
Score = 101 bits (243), Expect = 2e-20
Identities = 74/239 (30%), Positives = 117/239 (48%), Gaps = 13/239 (5%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLR-----ISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
TAV AA G +L + ++ + IS K G TPL +AA YG + V LL
Sbjct: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
Query: 1222 PGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYN 1281
+++ + GA PL A+ G+ VV+ LLN G + + N
Sbjct: 65 SASIEVGGSVNFDGETIEGAP----PLWAASAAGHLKVVQSLLNH-GASVNNTTLTNS-T 118
Query: 1282 PLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINA 1341
PL ACF GH+ IV L+ A+L ++RHG T L I+ GH ++ + LL +GA++N
Sbjct: 119 PLRAACFDGHLEIVKYLVEHKADL-EVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNR 177
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
G T LH A++G L+++K+L A + + P+ A+ H +++++L H
Sbjct: 178 KSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKD-GYGMTPLLSASVTGHTNIVDFLTH 235
Score = 90.2 bits (214), Expect = 7e-17
Identities = 69/252 (27%), Positives = 135/252 (53%), Gaps = 22/252 (8%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKA-----FINSKARNGRTALHLAAMNGYAHLVKFLIRD 1017
++A+ AA G L++ LL +K+ + S+ NG T L +AA G+ +V+FL+
Sbjct: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ 63
Query: 1018 HNAMIDV--------LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA 1069
+A I+V T++ PL A+A+G ++V + LL GA+++ T P+ AA
Sbjct: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
Query: 1070 AQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNK 1129
+ + E+V+ +L +H + + + G+TC I+ +G ++ + L++ G R
Sbjct: 124 CFDGHLEIVK-YLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLE---KGADVNRKS 179
Query: 1130 LNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM----R 1185
+ +T L AE G D++++L+ A +++ G+T + A+ GHTN++D + +
Sbjct: 180 VKGNTALHDCAESGSLDIMKMLLMYCAK-MEKDGYGMTPLLSASVTGHTNIVDFLTHHAQ 238
Query: 1186 STNTLRISSKKL 1197
++ T RI++ +L
Sbjct: 239 TSKTERINALEL 250
Score = 87.8 bits (208), Expect = 4e-16
Identities = 67/249 (26%), Positives = 120/249 (48%), Gaps = 13/249 (5%)
Query: 891 ETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLT 950
+TA A G ++T+++A S +VS ++ + + G TPLL+A GH+ +V LL
Sbjct: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTN-GATPLLMAARYGHLDMVEFLLE 62
Query: 951 N-HARVDV-----FD---VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
A ++V FD +EG L A+ G+L+V +LL + A +N+ T L
Sbjct: 63 QCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRA 122
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A +G+ +VK+L+ +H A ++V T L ++ G E+ + LLE GA+++
Sbjct: 123 ACFDGHLEIVKYLV-EHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK 181
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
G +H A++ +++++ L M G T A++ G +++ L +T
Sbjct: 182 GNTALHDCAESGSLDIMKMLLMYCAK--MEKDGYGMTPLLSASVTGHTNIVDFLTHHAQT 239
Query: 1122 GVISARNKL 1130
N L
Sbjct: 240 SKTERINAL 248
Score = 73.3 bits (172), Expect = 8e-12
Identities = 52/205 (25%), Positives = 102/205 (49%), Gaps = 6/205 (2%)
Query: 884 LQTRHNHETAFHYCAIAGNNDVMTEMIAHISTA-DVSRALNRQNSI--GWTPLLIACHRG 940
+ + N T A G+ D++ ++ S + +V ++N G PL A G
Sbjct: 35 ISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAG 94
Query: 941 HMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALH 1000
H+++V +LL + A V+ + + L A G+L++ L+ +KA + R+G T L
Sbjct: 95 HLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLM 154
Query: 1001 LAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDE 1060
++ G+ + ++L+ + A ++ ++K T LH A SG +++ K+LL A ++ D
Sbjct: 155 ISCYKGHKEIAQYLL-EKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDG 212
Query: 1061 LGQKPIHAAAQNNYSEVVQLFLQQH 1085
G P+ +A+ ++ +V FL H
Sbjct: 213 YGMTPLLSASVTGHTNIVD-FLTHH 236
Score = 72.1 bits (169), Expect = 2e-11
Identities = 75/252 (29%), Positives = 110/252 (43%), Gaps = 20/252 (7%)
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
D T V AA+ G L L LL + I + G TPL MA R D+V
Sbjct: 2 DLKTAVFNAARDGKLRLLTKLLASKSK--EEVSSLISEKTNGATPLLMAARYGHLDMVEF 59
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L+E S F D +GA L A +VV+ L+ +GA V
Sbjct: 60 LLEQCSASIEVGGSVNF-DGETIEGAPPLWAAS---------AAGHLKVVQSLLNHGASV 109
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ T N T G+ +++ ++ H + +VS N G T L+I+C++GH
Sbjct: 110 NNTTLTN-STPLRAACFDGHLEIVKYLVEHKADLEVS------NRHGHTCLMISCYKGHK 162
Query: 943 QLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLA 1002
++ LL A V+ V+G +ALH AE G L + LL A + K G T L A
Sbjct: 163 EIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKM-EKDGYGMTPLLSA 221
Query: 1003 AMNGYAHLVKFL 1014
++ G+ ++V FL
Sbjct: 222 SVTGHTNIVDFL 233
Score = 69.3 bits (162), Expect = 1e-10
Identities = 61/230 (26%), Positives = 107/230 (46%), Gaps = 28/230 (12%)
Query: 1156 ASCTDENRAGLTAVHLAAEHGHTNVLDVMRST--------NTLRISSKKL-GLTPLHIAA 1206
+S E G T + +AA +GH ++++ + ++ + + G PL A+
Sbjct: 32 SSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAAS 91
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS 1266
G + V+ LL+H G S+ S TPL A ++G+ +V+ L+
Sbjct: 92 AAGHLKVVQSLLNH-----------GASVNNTTLTNS--TPLRAACFDGHLEIVKYLVEH 138
Query: 1267 AGVQADA-ASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGH 1325
+AD SN +G+ L ++C+ GH I LL + A++ + + G T LH + G
Sbjct: 139 ---KADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVK-GNTALHDCAESGS 194
Query: 1326 YQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSE 1375
++++LL A++ D G TPL A+ GH N+V L + K+E
Sbjct: 195 LDIMKMLLMYCAKMEK-DGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTE 243
Score = 68.1 bits (159), Expect = 3e-10
Identities = 54/170 (31%), Positives = 78/170 (45%), Gaps = 11/170 (6%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAG---VQADAASNENGYNPLHLACFGGHMSIVGLLL--- 1299
T + AA +G ++ LL S V + + NG PL +A GH+ +V LL
Sbjct: 5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQC 64
Query: 1300 SRSAELLHSTDRHGKT-----GLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
S S E+ S + G+T L AS GH ++V+ LL GA +N T TPL A
Sbjct: 65 SASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAAC 124
Query: 1355 KAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
GHL +VK L E A + + + + H ++ +YLL K D
Sbjct: 125 FDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGAD 174
Score = 62.5 bits (145), Expect = 2e-08
Identities = 54/166 (32%), Positives = 80/166 (48%), Gaps = 17/166 (10%)
Query: 1297 LLLSRSAE---LLHSTDRHGKTGLHIASTHGHYQMVEVLLGQ-------GAEINATDKN- 1345
LL S+S E L S +G T L +A+ +GH MVE LL Q G +N +
Sbjct: 22 LLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETI 81
Query: 1346 -GWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
G PL A+ AGHL VV+ L GAS + T N P+ A + H ++++YL+ EH
Sbjct: 82 EGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLV--EHK 139
Query: 1405 TQSLMDDKRFVYNLMV-CSKNHNNIPIEEFVLVSPAPVDTAAKLSN 1449
+ ++ LM+ C K H I +++L A V+ + N
Sbjct: 140 ADLEVSNRHGHTCLMISCYKGHKE--IAQYLLEKGADVNRKSVKGN 183
Score = 59.7 bits (138), Expect = 1e-07
Identities = 45/175 (25%), Positives = 80/175 (45%), Gaps = 10/175 (5%)
Query: 52 KKLIRDLVFQR--GKVPLLLAVEAGNQSMVRELLSAQTAE-------QLKATTPAGDTAL 102
K+ + L+ ++ G PLL+A G+ MV LL +A T G L
Sbjct: 28 KEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPL 87
Query: 103 HLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADN 162
A+ + + + L+++GA V+ T TPL A +G +VKY +A+ +++
Sbjct: 88 WAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNR 147
Query: 163 EDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
T + ++ GH I + L +K A + ++ G+T +H + +G D ML
Sbjct: 148 HGHTCLMISCYKGHKEIAQYLLEK-GADVNRKSVKGNTALHDCAESGSLDIMKML 201
Score = 58.8 bits (136), Expect = 2e-07
Identities = 66/249 (26%), Positives = 104/249 (41%), Gaps = 28/249 (11%)
Query: 1095 DGNTCAHIAAIQGSVKVIEELMKFDRTGVISA--RNKLNDSTPLQLAAEGGHADVVRVL- 1151
D T AA G ++++ +L+ +S+ K N +TPL +AA GH D+V L
Sbjct: 2 DLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLL 61
Query: 1152 ------VRAGASCT--DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLH 1203
+ G S E G + A+ GH V+ + + ++ TPL
Sbjct: 62 EQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLR 121
Query: 1204 IAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLL 1263
A + G E V+ L+ H +A VS G T L ++ Y G++ + + L
Sbjct: 122 AACFDGHLEIVKYLVEH-------KADLEVS------NRHGHTCLMISCYKGHKEIAQYL 168
Query: 1264 LNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTH 1323
L G + S G LH G + I+ +LL A++ D +G T L AS
Sbjct: 169 LEK-GADVNRKS-VKGNTALHDCAESGSLDIMKMLLMYCAKM--EKDGYGMTPLLSASVT 224
Query: 1324 GHYQMVEVL 1332
GH +V+ L
Sbjct: 225 GHTNIVDFL 233
Score = 56.0 bits (129), Expect = 1e-06
Identities = 62/231 (26%), Positives = 106/231 (45%), Gaps = 43/231 (18%)
Query: 732 TPLHIAARIPDGDKCALML------LKSGAGPN--KATEDGMTPVHVAAKFGNLATLVLL 783
TPL +AAR D +L ++ G N T +G P+ A+ G+L + L
Sbjct: 43 TPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSL 102
Query: 784 LEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAV 843
L G T +T TPL+ AC +IV++L+E HK + ++
Sbjct: 103 LNHGASVNNTT-------LTNSTPLRAACFDGHLEIVKYLVE----HKAD------LEVS 145
Query: 844 DEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN 903
+ G + L +C +++ + L+E GADV+ ++ + TA H CA +G+
Sbjct: 146 NRHGHTCLMISCY---------KGHKEIAQYLLEKGADVNRKSVKGN-TALHDCAESGSL 195
Query: 904 DVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHAR 954
D+M ++ + + + ++ G TPLL A GH +V+ LT+HA+
Sbjct: 196 DIMKMLLMYCAKME-------KDGYGMTPLLSASVTGHTNIVD-FLTHHAQ 238
Score = 52.0 bits (119), Expect = 2e-05
Identities = 37/123 (30%), Positives = 62/123 (50%), Gaps = 2/123 (1%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+GA + A+ GH+ ++ +LL G SV+ TT N T L A +V+ L+ + AD
Sbjct: 82 EGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKAD 141
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ + + T L I+ + A LL+ GA N+ + G T +H A+ G+L +
Sbjct: 142 LEV-SNRHGHTCLMISC-YKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMK 199
Query: 782 LLL 784
+LL
Sbjct: 200 MLL 202
Score = 50.4 bits (115), Expect = 7e-05
Identities = 44/170 (25%), Positives = 76/170 (44%), Gaps = 13/170 (7%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPA---GDTALHLAARRRDVDMARILVDY 120
K + A G ++ +LL++++ E++ + G T L +AAR +DM L++
Sbjct: 4 KTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQ 63
Query: 121 --------GAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLA 171
G+V D G PL A+A G +V+ A+ + TP+ A
Sbjct: 64 CSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAA 123
Query: 172 AENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+GH I++ L + KA + + G T + I+ GH + A L +KG
Sbjct: 124 CFDGHLEIVKYLVEH-KADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKG 172
Score = 42.7 bits (96), Expect = 0.014
Identities = 34/129 (26%), Positives = 58/129 (44%), Gaps = 3/129 (2%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL A G+ +V+ L+ + L+ + G T L ++ + ++A+ L++ GA V+
Sbjct: 119 PLRAACFDGHLEIVKYLVEHKA--DLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVN 176
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ G T LH A G ++K A D TP+ A+ GH I++ L
Sbjct: 177 RKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTH 235
Query: 186 KFKASIFER 194
+ S ER
Sbjct: 236 HAQTSKTER 244
Score = 39.5 bits (88), Expect = 0.13
Identities = 30/108 (27%), Positives = 50/108 (46%), Gaps = 3/108 (2%)
Query: 1327 QMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFA 1386
Q+ +L+ GA++N D + +PLH AA H +++ LL +SGA TNL+
Sbjct: 509 QVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAH-FDATNLHKQTASDL 567
Query: 1387 ASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFV 1434
E ++ + L+ + T R + N + K H +E FV
Sbjct: 568 LDE--KEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGHIPEKLETFV 613
Score = 38.3 bits (85), Expect = 0.29
Identities = 50/175 (28%), Positives = 76/175 (43%), Gaps = 20/175 (11%)
Query: 662 DGARSIHTAARYGHVGIINTLLQK-------GESV--DVTTNDNYTALHIAVESCKPAVV 712
+GA + AARYGH+ ++ LL++ G SV D T + L A + VV
Sbjct: 40 NGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVV 99
Query: 713 ETLLGYGADVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVA 771
++LL +GA V+ TPL A DG + L++ A + G T + ++
Sbjct: 100 QSLLNHGASVN-NTTLTNSTPLRAACF--DGHLEIVKYLVEHKADLEVSNRHGHTCLMIS 156
Query: 772 AKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
G+ LLE G D RK+ V G T L S DI++ L+ +
Sbjct: 157 CYKGHKEIAQYLLEKGADVNRKS-------VKGNTALHDCAESGSLDIMKMLLMY 204
Score = 36.7 bits (81), Expect = 0.89
Identities = 13/42 (30%), Positives = 27/42 (64%)
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
++V +L+E GA+++ D P+H AA NN+ +++ L ++
Sbjct: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIK 549
Score = 35.5 bits (78), Expect = 2.1
Identities = 23/89 (25%), Positives = 46/89 (51%), Gaps = 3/89 (3%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G L+++ G++ + + LL + + + G+TALH A +D+ ++L+ Y
Sbjct: 147 RHGHTCLMISCYKGHKEIAQYLL--EKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMY 204
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKY 149
A ++ +G G TPL A+ G +V +
Sbjct: 205 CAKME-KDGYGMTPLLSASVTGHTNIVDF 232
Score = 35.5 bits (78), Expect = 2.1
Identities = 22/63 (34%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Query: 189 ASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDEVLFVK-IENG 247
A + R D ++ +HIA+LN H D +L K G + N KQT ++L K I
Sbjct: 519 ADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATN--LHKQTASDLLDEKEIAKN 576
Query: 248 LIK 250
LI+
Sbjct: 577 LIQ 579
Score = 33.5 bits (73), Expect = 8.3
Identities = 19/57 (33%), Positives = 30/57 (52%), Gaps = 1/57 (1%)
Query: 975 LQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQT 1031
LQV L+ A +N + + + LH+AA+N + ++ LI+ A D L KQT
Sbjct: 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKS-GAHFDATNLHKQT 563
>BC004988-1|AAH04988.1| 669|Homo sapiens fem-1 homolog a (C. elegans)
protein.
Length = 669
Score = 100 bits (239), Expect = 6e-20
Identities = 75/241 (31%), Positives = 116/241 (48%), Gaps = 12/241 (4%)
Query: 1167 TAVHLAAEHGHTNVLDVM---RSTNTLRISSKKL--GLTPLHIAAYYGQAETVRELLSHV 1221
TAV+ AA G +L + RS L + ++ G TPL IAA YG + V L+
Sbjct: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
Query: 1222 PGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYN 1281
+V++ + GA PL A+ G+ +VVR LL G + + N
Sbjct: 65 GASVEAGGSVHFDGETIEGAP----PLWAASAAGHLDVVRSLLRR-GASVNRTTRTNS-T 118
Query: 1282 PLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINA 1341
PL ACF GH+ +V L+ L +RHG T L I+ GH ++ LL QGA++N
Sbjct: 119 PLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNR 178
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
G T LH A++G L +++LL A + + P+ A+ H +++EYL+ +
Sbjct: 179 RSAKGNTALHDCAESGSLEILQLLLGCKARMERD-GYGMTPLLAASVTGHTNIVEYLIQE 237
Query: 1402 E 1402
+
Sbjct: 238 Q 238
Score = 86.2 bits (204), Expect = 1e-15
Identities = 65/235 (27%), Positives = 111/235 (47%), Gaps = 12/235 (5%)
Query: 892 TAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTN 951
TA + A G ++ ++++ S ++ L + + G TPLLIA GH+ +V L+
Sbjct: 5 TAVYNAARDGKLQLLQKLLSGRSREELDE-LTGEVAGGGTPLLIAARYGHLDVVEYLVDR 63
Query: 952 -HARVDV-----FD---VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLA 1002
A V+ FD +EG L A+ G+L V +LL A +N R T L A
Sbjct: 64 CGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAA 123
Query: 1003 AMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELG 1062
+G+ +V++L+ +H A ++V T L ++ G E+ + LLE GA ++ G
Sbjct: 124 CFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKG 183
Query: 1063 QKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMK 1117
+H A++ E++QL L M G T A++ G ++E L++
Sbjct: 184 NTALHDCAESGSLEILQLLLGCKAR--MERDGYGMTPLLAASVTGHTNIVEYLIQ 236
Score = 77.0 bits (181), Expect = 7e-13
Identities = 74/255 (29%), Positives = 118/255 (46%), Gaps = 19/255 (7%)
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
D T V+ AA+ G L L LL G + +V G TPL +A R D+V +
Sbjct: 2 DLRTAVYNAARDGKLQLLQKLLS--GRSREELDELTGEVAGGGTPLLIAARYGHLDVVEY 59
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L++ E+ + D +GA L A VV+ L+ GA V
Sbjct: 60 LVDRC-GASVEAGGSVHFDGETIEGAPPLWAAS---------AAGHLDVVRSLLRRGASV 109
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ TR N T G+ +V+ ++ AD+ A N G T L+I+C++GH
Sbjct: 110 NRTTRTN-STPLRAACFDGHLEVVRYLVGE-HQADLEVA----NRHGHTCLMISCYKGHR 163
Query: 943 QLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLA 1002
++ LL A+V+ +G +ALH AE G L++ LL KA + + G T L A
Sbjct: 164 EIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARM-ERDGYGMTPLLAA 222
Query: 1003 AMNGYAHLVKFLIRD 1017
++ G+ ++V++LI++
Sbjct: 223 SVTGHTNIVEYLIQE 237
Score = 75.8 bits (178), Expect = 2e-12
Identities = 65/241 (26%), Positives = 116/241 (48%), Gaps = 17/241 (7%)
Query: 996 RTALHLAAMNGYAHLVKFLIRDHNAM-IDVLTLKKQ---TPLHLAAASGQIEVCKLLLE- 1050
RTA++ AA +G L++ L+ + +D LT + TPL +AA G ++V + L++
Sbjct: 4 RTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDR 63
Query: 1051 LGANIDATDEL--------GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHI 1102
GA+++A + G P+ AA+ + +VV+ L++ + V TT+ +T
Sbjct: 64 CGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGAS-VNRTTRTNSTPLRA 122
Query: 1103 AAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDEN 1162
A G ++V+ L+ + + N+ + T L ++ GH ++ R L+ GA +
Sbjct: 123 ACFDGHLEVVRYLVG-EHQADLEVANR-HGHTCLMISCYKGHREIARYLLEQGAQVNRRS 180
Query: 1163 RAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVP 1222
G TA+H AE G +L ++ R+ G+TPL A+ G V L+ P
Sbjct: 181 AKGNTALHDCAESGSLEILQLLLGCKA-RMERDGYGMTPLLAASVTGHTNIVEYLIQEQP 239
Query: 1223 G 1223
G
Sbjct: 240 G 240
Score = 59.3 bits (137), Expect = 1e-07
Identities = 64/213 (30%), Positives = 91/213 (42%), Gaps = 27/213 (12%)
Query: 1096 GNTCAHIAAIQGSVKVIEELMKFDRTGV-ISARNKLN-------DSTPLQLAAEGGHADV 1147
G T IAA G + V+E L+ DR G + A ++ + PL A+ GH DV
Sbjct: 41 GGTPLLIAARYGHLDVVEYLV--DRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDV 98
Query: 1148 VRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS-SKKLGLTPLHIAA 1206
VR L+R GAS R T + A GH V+ + + + + + G T L I+
Sbjct: 99 VRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISC 158
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS 1266
Y G E R LL + A G T LH A +G+ +++LLL
Sbjct: 159 YKGHREIARYLLEQGAQVNRRSA-------------KGNTALHDCAESGSLEILQLLL-- 203
Query: 1267 AGVQADAASNENGYNPLHLACFGGHMSIVGLLL 1299
G +A + G PL A GH +IV L+
Sbjct: 204 -GCKARMERDGYGMTPLLAASVTGHTNIVEYLI 235
Score = 58.0 bits (134), Expect = 3e-07
Identities = 45/168 (26%), Positives = 76/168 (45%), Gaps = 12/168 (7%)
Query: 70 AVEAGNQSMVRELLSAQTAEQLKATT---PAGDTALHLAARRRDVDMARILVDY-GAVVD 125
A G ++++LLS ++ E+L T G T L +AAR +D+ LVD GA V+
Sbjct: 10 AARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVE 69
Query: 126 ATNGA--------GQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
A G PL A+A G +V+ A+ + TP+ A +GH
Sbjct: 70 AGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHL 129
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
++ L + +A + + G T + I+ GH + A L ++G ++
Sbjct: 130 EVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVN 177
Score = 55.6 bits (128), Expect = 2e-06
Identities = 41/124 (33%), Positives = 64/124 (51%), Gaps = 3/124 (2%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG-YGA 720
+GA + A+ GH+ ++ +LL++G SV+ TT N T L A VV L+G + A
Sbjct: 82 EGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQA 141
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
D+ + + T L I+ + A LL+ GA N+ + G T +H A+ G+L L
Sbjct: 142 DLEV-ANRHGHTCLMISC-YKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEIL 199
Query: 781 VLLL 784
LLL
Sbjct: 200 QLLL 203
Score = 52.4 bits (120), Expect = 2e-05
Identities = 35/118 (29%), Positives = 56/118 (47%), Gaps = 2/118 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL A G+ +VR L+ A+ L+ G T L ++ + ++AR L++ GA V+
Sbjct: 119 PLRAACFDGHLEVVRYLVGEHQAD-LEVANRHGHTCLMISCYKGHREIARYLLEQGAQVN 177
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
+ G T LH A G +++ G +A D TP+ A+ GH I+E L
Sbjct: 178 RRSAKGNTALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYL 234
Score = 35.9 bits (79), Expect = 1.6
Identities = 20/51 (39%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 1009 HLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATD 1059
H+VK L+ D A D TPLH+AA + + L+E GA++DAT+
Sbjct: 562 HVVKVLL-DCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATN 611
Score = 34.7 bits (76), Expect = 3.6
Identities = 17/53 (32%), Positives = 27/53 (50%)
Query: 668 HTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
+ R+ + ++ LL G D DN T LHIA ++ PA++ L+ GA
Sbjct: 553 YPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGA 605
Score = 34.7 bits (76), Expect = 3.6
Identities = 15/42 (35%), Positives = 25/42 (59%)
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
+ V K+LL+ GA+ D+ D P+H AAQNN ++ ++
Sbjct: 561 LHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIE 602
>AY356352-1|AAR10439.1| 669|Homo sapiens prostaglandin E receptor
4-associated protein protein.
Length = 669
Score = 100 bits (239), Expect = 6e-20
Identities = 75/241 (31%), Positives = 116/241 (48%), Gaps = 12/241 (4%)
Query: 1167 TAVHLAAEHGHTNVLDVM---RSTNTLRISSKKL--GLTPLHIAAYYGQAETVRELLSHV 1221
TAV+ AA G +L + RS L + ++ G TPL IAA YG + V L+
Sbjct: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
Query: 1222 PGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYN 1281
+V++ + GA PL A+ G+ +VVR LL G + + N
Sbjct: 65 GASVEAGGSVHFDGETIEGAP----PLWAASAAGHLDVVRSLLRR-GASVNRTTRTNS-T 118
Query: 1282 PLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINA 1341
PL ACF GH+ +V L+ L +RHG T L I+ GH ++ LL QGA++N
Sbjct: 119 PLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNR 178
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
G T LH A++G L +++LL A + + P+ A+ H +++EYL+ +
Sbjct: 179 RSAKGNTALHDCAESGSLEILQLLLGCKARMERD-GYGMTPLLAASVTGHTNIVEYLIQE 237
Query: 1402 E 1402
+
Sbjct: 238 Q 238
Score = 86.2 bits (204), Expect = 1e-15
Identities = 65/235 (27%), Positives = 111/235 (47%), Gaps = 12/235 (5%)
Query: 892 TAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTN 951
TA + A G ++ ++++ S ++ L + + G TPLLIA GH+ +V L+
Sbjct: 5 TAVYNAARDGKLQLLQKLLSGRSREELDE-LTGEVAGGGTPLLIAARYGHLDVVEYLVDR 63
Query: 952 -HARVDV-----FD---VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLA 1002
A V+ FD +EG L A+ G+L V +LL A +N R T L A
Sbjct: 64 CGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAA 123
Query: 1003 AMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELG 1062
+G+ +V++L+ +H A ++V T L ++ G E+ + LLE GA ++ G
Sbjct: 124 CFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKG 183
Query: 1063 QKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMK 1117
+H A++ E++QL L M G T A++ G ++E L++
Sbjct: 184 NTALHDCAESGSLEILQLLLGCKAR--MERDGYGMTPLLAASVTGHTNIVEYLIQ 236
Score = 77.0 bits (181), Expect = 7e-13
Identities = 74/255 (29%), Positives = 118/255 (46%), Gaps = 19/255 (7%)
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
D T V+ AA+ G L L LL G + +V G TPL +A R D+V +
Sbjct: 2 DLRTAVYNAARDGKLQLLQKLLS--GRSREELDELTGEVAGGGTPLLIAARYGHLDVVEY 59
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L++ E+ + D +GA L A VV+ L+ GA V
Sbjct: 60 LVDRC-GASVEAGGSVHFDGETIEGAPPLWAAS---------AAGHLDVVRSLLRRGASV 109
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ TR N T G+ +V+ ++ AD+ A N G T L+I+C++GH
Sbjct: 110 NRTTRTN-STPLRAACFDGHLEVVRYLVGE-HQADLEVA----NRHGHTCLMISCYKGHR 163
Query: 943 QLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLA 1002
++ LL A+V+ +G +ALH AE G L++ LL KA + + G T L A
Sbjct: 164 EIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARM-ERDGYGMTPLLAA 222
Query: 1003 AMNGYAHLVKFLIRD 1017
++ G+ ++V++LI++
Sbjct: 223 SVTGHTNIVEYLIQE 237
Score = 75.8 bits (178), Expect = 2e-12
Identities = 65/241 (26%), Positives = 116/241 (48%), Gaps = 17/241 (7%)
Query: 996 RTALHLAAMNGYAHLVKFLIRDHNAM-IDVLTLKKQ---TPLHLAAASGQIEVCKLLLE- 1050
RTA++ AA +G L++ L+ + +D LT + TPL +AA G ++V + L++
Sbjct: 4 RTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDR 63
Query: 1051 LGANIDATDEL--------GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHI 1102
GA+++A + G P+ AA+ + +VV+ L++ + V TT+ +T
Sbjct: 64 CGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGAS-VNRTTRTNSTPLRA 122
Query: 1103 AAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDEN 1162
A G ++V+ L+ + + N+ + T L ++ GH ++ R L+ GA +
Sbjct: 123 ACFDGHLEVVRYLVG-EHQADLEVANR-HGHTCLMISCYKGHREIARYLLEQGAQVNRRS 180
Query: 1163 RAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVP 1222
G TA+H AE G +L ++ R+ G+TPL A+ G V L+ P
Sbjct: 181 AKGNTALHDCAESGSLEILQLLLGCKA-RMERDGYGMTPLLAASVTGHTNIVEYLIQEQP 239
Query: 1223 G 1223
G
Sbjct: 240 G 240
Score = 59.3 bits (137), Expect = 1e-07
Identities = 64/213 (30%), Positives = 91/213 (42%), Gaps = 27/213 (12%)
Query: 1096 GNTCAHIAAIQGSVKVIEELMKFDRTGV-ISARNKLN-------DSTPLQLAAEGGHADV 1147
G T IAA G + V+E L+ DR G + A ++ + PL A+ GH DV
Sbjct: 41 GGTPLLIAARYGHLDVVEYLV--DRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDV 98
Query: 1148 VRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS-SKKLGLTPLHIAA 1206
VR L+R GAS R T + A GH V+ + + + + + G T L I+
Sbjct: 99 VRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISC 158
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS 1266
Y G E R LL + A G T LH A +G+ +++LLL
Sbjct: 159 YKGHREIARYLLEQGAQVNRRSA-------------KGNTALHDCAESGSLEILQLLL-- 203
Query: 1267 AGVQADAASNENGYNPLHLACFGGHMSIVGLLL 1299
G +A + G PL A GH +IV L+
Sbjct: 204 -GCKARMERDGYGMTPLLAASVTGHTNIVEYLI 235
Score = 58.0 bits (134), Expect = 3e-07
Identities = 45/168 (26%), Positives = 76/168 (45%), Gaps = 12/168 (7%)
Query: 70 AVEAGNQSMVRELLSAQTAEQLKATT---PAGDTALHLAARRRDVDMARILVDY-GAVVD 125
A G ++++LLS ++ E+L T G T L +AAR +D+ LVD GA V+
Sbjct: 10 AARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVE 69
Query: 126 ATNGA--------GQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
A G PL A+A G +V+ A+ + TP+ A +GH
Sbjct: 70 AGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHL 129
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
++ L + +A + + G T + I+ GH + A L ++G ++
Sbjct: 130 EVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVN 177
Score = 55.6 bits (128), Expect = 2e-06
Identities = 41/124 (33%), Positives = 64/124 (51%), Gaps = 3/124 (2%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG-YGA 720
+GA + A+ GH+ ++ +LL++G SV+ TT N T L A VV L+G + A
Sbjct: 82 EGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQA 141
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
D+ + + T L I+ + A LL+ GA N+ + G T +H A+ G+L L
Sbjct: 142 DLEV-ANRHGHTCLMISC-YKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEIL 199
Query: 781 VLLL 784
LLL
Sbjct: 200 QLLL 203
Score = 52.4 bits (120), Expect = 2e-05
Identities = 35/118 (29%), Positives = 56/118 (47%), Gaps = 2/118 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL A G+ +VR L+ A+ L+ G T L ++ + ++AR L++ GA V+
Sbjct: 119 PLRAACFDGHLEVVRYLVGEHQAD-LEVANRHGHTCLMISCYKGHREIARYLLEQGAQVN 177
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
+ G T LH A G +++ G +A D TP+ A+ GH I+E L
Sbjct: 178 RRSAKGNTALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYL 234
Score = 35.9 bits (79), Expect = 1.6
Identities = 20/51 (39%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 1009 HLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATD 1059
H+VK L+ D A D TPLH+AA + + L+E GA++DAT+
Sbjct: 562 HVVKVLL-DCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATN 611
Score = 34.7 bits (76), Expect = 3.6
Identities = 17/53 (32%), Positives = 27/53 (50%)
Query: 668 HTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
+ R+ + ++ LL G D DN T LHIA ++ PA++ L+ GA
Sbjct: 553 YPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGA 605
Score = 34.7 bits (76), Expect = 3.6
Identities = 15/42 (35%), Positives = 25/42 (59%)
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
+ V K+LL+ GA+ D+ D P+H AAQNN ++ ++
Sbjct: 561 LHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIE 602
>AJ311359-1|CAC85342.1| 668|Homo sapiens putative sex determining
protein protein.
Length = 668
Score = 100 bits (239), Expect = 6e-20
Identities = 75/241 (31%), Positives = 116/241 (48%), Gaps = 12/241 (4%)
Query: 1167 TAVHLAAEHGHTNVLDVM---RSTNTLRISSKKL--GLTPLHIAAYYGQAETVRELLSHV 1221
TAV+ AA G +L + RS L + ++ G TPL IAA YG + V L+
Sbjct: 4 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 63
Query: 1222 PGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYN 1281
+V++ + GA PL A+ G+ +VVR LL G + + N
Sbjct: 64 GASVEAGGSVHFDGETIEGAP----PLWAASAAGHLDVVRSLLRR-GASVNRTTRTNS-T 117
Query: 1282 PLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINA 1341
PL ACF GH+ +V L+ L +RHG T L I+ GH ++ LL QGA++N
Sbjct: 118 PLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNR 177
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
G T LH A++G L +++LL A + + P+ A+ H +++EYL+ +
Sbjct: 178 RSAKGNTALHDCAESGSLEILQLLLGCKARMERD-GYGMTPLLAASVTGHTNIVEYLIQE 236
Query: 1402 E 1402
+
Sbjct: 237 Q 237
Score = 86.2 bits (204), Expect = 1e-15
Identities = 65/235 (27%), Positives = 111/235 (47%), Gaps = 12/235 (5%)
Query: 892 TAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTN 951
TA + A G ++ ++++ S ++ L + + G TPLLIA GH+ +V L+
Sbjct: 4 TAVYNAARDGKLQLLQKLLSGRSREELDE-LTGEVAGGGTPLLIAARYGHLDVVEYLVDR 62
Query: 952 -HARVDV-----FD---VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLA 1002
A V+ FD +EG L A+ G+L V +LL A +N R T L A
Sbjct: 63 CGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAA 122
Query: 1003 AMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELG 1062
+G+ +V++L+ +H A ++V T L ++ G E+ + LLE GA ++ G
Sbjct: 123 CFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKG 182
Query: 1063 QKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMK 1117
+H A++ E++QL L M G T A++ G ++E L++
Sbjct: 183 NTALHDCAESGSLEILQLLLGCKAR--MERDGYGMTPLLAASVTGHTNIVEYLIQ 235
Score = 77.0 bits (181), Expect = 7e-13
Identities = 74/255 (29%), Positives = 118/255 (46%), Gaps = 19/255 (7%)
Query: 763 DGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
D T V+ AA+ G L L LL G + +V G TPL +A R D+V +
Sbjct: 1 DLRTAVYNAARDGKLQLLQKLLS--GRSREELDELTGEVAGGGTPLLIAARYGHLDVVEY 58
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L++ E+ + D +GA L A VV+ L+ GA V
Sbjct: 59 LVDRC-GASVEAGGSVHFDGETIEGAPPLWAAS---------AAGHLDVVRSLLRRGASV 108
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ TR N T G+ +V+ ++ AD+ A N G T L+I+C++GH
Sbjct: 109 NRTTRTN-STPLRAACFDGHLEVVRYLVGE-HQADLEVA----NRHGHTCLMISCYKGHR 162
Query: 943 QLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLA 1002
++ LL A+V+ +G +ALH AE G L++ LL KA + + G T L A
Sbjct: 163 EIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARM-ERDGYGMTPLLAA 221
Query: 1003 AMNGYAHLVKFLIRD 1017
++ G+ ++V++LI++
Sbjct: 222 SVTGHTNIVEYLIQE 236
Score = 75.8 bits (178), Expect = 2e-12
Identities = 65/241 (26%), Positives = 116/241 (48%), Gaps = 17/241 (7%)
Query: 996 RTALHLAAMNGYAHLVKFLIRDHNAM-IDVLTLKKQ---TPLHLAAASGQIEVCKLLLE- 1050
RTA++ AA +G L++ L+ + +D LT + TPL +AA G ++V + L++
Sbjct: 3 RTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDR 62
Query: 1051 LGANIDATDEL--------GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHI 1102
GA+++A + G P+ AA+ + +VV+ L++ + V TT+ +T
Sbjct: 63 CGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGAS-VNRTTRTNSTPLRA 121
Query: 1103 AAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDEN 1162
A G ++V+ L+ + + N+ + T L ++ GH ++ R L+ GA +
Sbjct: 122 ACFDGHLEVVRYLVG-EHQADLEVANR-HGHTCLMISCYKGHREIARYLLEQGAQVNRRS 179
Query: 1163 RAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVP 1222
G TA+H AE G +L ++ R+ G+TPL A+ G V L+ P
Sbjct: 180 AKGNTALHDCAESGSLEILQLLLGCKA-RMERDGYGMTPLLAASVTGHTNIVEYLIQEQP 238
Query: 1223 G 1223
G
Sbjct: 239 G 239
Score = 59.3 bits (137), Expect = 1e-07
Identities = 64/213 (30%), Positives = 91/213 (42%), Gaps = 27/213 (12%)
Query: 1096 GNTCAHIAAIQGSVKVIEELMKFDRTGV-ISARNKLN-------DSTPLQLAAEGGHADV 1147
G T IAA G + V+E L+ DR G + A ++ + PL A+ GH DV
Sbjct: 40 GGTPLLIAARYGHLDVVEYLV--DRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDV 97
Query: 1148 VRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS-SKKLGLTPLHIAA 1206
VR L+R GAS R T + A GH V+ + + + + + G T L I+
Sbjct: 98 VRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISC 157
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS 1266
Y G E R LL + A G T LH A +G+ +++LLL
Sbjct: 158 YKGHREIARYLLEQGAQVNRRSA-------------KGNTALHDCAESGSLEILQLLL-- 202
Query: 1267 AGVQADAASNENGYNPLHLACFGGHMSIVGLLL 1299
G +A + G PL A GH +IV L+
Sbjct: 203 -GCKARMERDGYGMTPLLAASVTGHTNIVEYLI 234
Score = 58.0 bits (134), Expect = 3e-07
Identities = 45/168 (26%), Positives = 76/168 (45%), Gaps = 12/168 (7%)
Query: 70 AVEAGNQSMVRELLSAQTAEQLKATT---PAGDTALHLAARRRDVDMARILVDY-GAVVD 125
A G ++++LLS ++ E+L T G T L +AAR +D+ LVD GA V+
Sbjct: 9 AARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVE 68
Query: 126 ATNGA--------GQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
A G PL A+A G +V+ A+ + TP+ A +GH
Sbjct: 69 AGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHL 128
Query: 178 AIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLH 225
++ L + +A + + G T + I+ GH + A L ++G ++
Sbjct: 129 EVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVN 176
Score = 55.6 bits (128), Expect = 2e-06
Identities = 41/124 (33%), Positives = 64/124 (51%), Gaps = 3/124 (2%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG-YGA 720
+GA + A+ GH+ ++ +LL++G SV+ TT N T L A VV L+G + A
Sbjct: 81 EGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQA 140
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
D+ + + T L I+ + A LL+ GA N+ + G T +H A+ G+L L
Sbjct: 141 DLEV-ANRHGHTCLMISC-YKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEIL 198
Query: 781 VLLL 784
LLL
Sbjct: 199 QLLL 202
Score = 52.4 bits (120), Expect = 2e-05
Identities = 35/118 (29%), Positives = 56/118 (47%), Gaps = 2/118 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL A G+ +VR L+ A+ L+ G T L ++ + ++AR L++ GA V+
Sbjct: 118 PLRAACFDGHLEVVRYLVGEHQAD-LEVANRHGHTCLMISCYKGHREIARYLLEQGAQVN 176
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
+ G T LH A G +++ G +A D TP+ A+ GH I+E L
Sbjct: 177 RRSAKGNTALHDCAESGSLEILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYL 233
Score = 35.9 bits (79), Expect = 1.6
Identities = 20/51 (39%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 1009 HLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATD 1059
H+VK L+ D A D TPLH+AA + + L+E GA++DAT+
Sbjct: 561 HVVKVLL-DCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATN 610
Score = 34.7 bits (76), Expect = 3.6
Identities = 17/53 (32%), Positives = 27/53 (50%)
Query: 668 HTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA 720
+ R+ + ++ LL G D DN T LHIA ++ PA++ L+ GA
Sbjct: 552 YPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGA 604
Score = 34.7 bits (76), Expect = 3.6
Identities = 15/42 (35%), Positives = 25/42 (59%)
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
+ V K+LL+ GA+ D+ D P+H AAQNN ++ ++
Sbjct: 560 LHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIE 601
>AL035288-1|CAA22892.1| 671|Homo sapiens hypothetical protein
protein.
Length = 671
Score = 98.7 bits (235), Expect = 2e-19
Identities = 77/245 (31%), Positives = 115/245 (46%), Gaps = 6/245 (2%)
Query: 959 DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN-GRTALHLAAMNGYAHLVKFLIRD 1017
D G + LHL A G+ +V + LL + + A + G +H AA G ++ L+R
Sbjct: 3 DNSGPTVLHLTARFGHPKVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVRH 62
Query: 1018 HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL-ELGANIDATDELGQKPIHAAAQNNYSE 1076
+ ++ T TPL+LA G +EV + L+ E GA+ A G P+HAAAQ +S
Sbjct: 63 YPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSP 122
Query: 1077 VVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPL 1136
V+ + + KDG T H AA +G KV+ L+ G ISA L T L
Sbjct: 123 VIVWLVSCTDVSLSEQDKDGATATHFAASRGHSKVLSWLLLHG--GEISA--DLWGGTAL 178
Query: 1137 QLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
AAE G + ++LV GA +R G A L+ +GH++ +R+ L +
Sbjct: 179 YDAAENGELECCQILVVNGAELEVRDRDGYAAADLSDFNGHSHCTHCLRTVENLSMEHCV 238
Query: 1197 LGLTP 1201
L P
Sbjct: 239 LSRDP 243
Score = 97.1 bits (231), Expect = 6e-19
Identities = 65/212 (30%), Positives = 107/212 (50%), Gaps = 15/212 (7%)
Query: 1160 DENRAGLTAVHLAAEHGHTNVLD-VMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
D++ +G T +HL A GH V++ ++ ++ +G P+H AA G ++R L+
Sbjct: 1 DKDNSGPTVLHLTARFGHPKVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 60
Query: 1219 SHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNEN 1278
H P V ++ ++G TPL+LA G+ V + L+ G A +++
Sbjct: 61 RHYPEGVNAQT------------KNGATPLYLACQEGHLEVTQYLVQECGADPHARAHD- 107
Query: 1279 GYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAE 1338
G PLH A GH ++ L+S + L D+ G T H A++ GH +++ LL G E
Sbjct: 108 GMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATATHFAASRGHSKVLSWLLLHGGE 167
Query: 1339 INATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
I+A D G T L+ AA+ G L ++L +GA
Sbjct: 168 ISA-DLWGGTALYDAAENGELECCQILVVNGA 198
Score = 80.2 bits (189), Expect = 7e-14
Identities = 61/190 (32%), Positives = 96/190 (50%), Gaps = 5/190 (2%)
Query: 1031 TPLHLAAASGQIEVCKLLLELGA-NIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
T LHL A G +V LL G + A ++G PIH AA ++L ++ +P V
Sbjct: 8 TVLHLTARFGHPKVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVRHYPEGV 67
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVR 1149
A TK+G T ++A +G ++V + L++ G + TPL AA+ GH+ V+
Sbjct: 68 NAQTKNGATPLYLACQEGHLEVTQYLVQ--ECGADPHARAHDGMTPLHAAAQMGHSPVIV 125
Query: 1150 VLVR-AGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYY 1208
LV S +++++ G TA H AA GH+ VL + + IS+ G T L+ AA
Sbjct: 126 WLVSCTDVSLSEQDKDGATATHFAASRGHSKVLSWL-LLHGGEISADLWGGTALYDAAEN 184
Query: 1209 GQAETVRELL 1218
G+ E + L+
Sbjct: 185 GELECCQILV 194
Score = 77.0 bits (181), Expect = 7e-13
Identities = 78/275 (28%), Positives = 126/275 (45%), Gaps = 32/275 (11%)
Query: 764 GMTPVHVAAKFGNLATLVLLLEDGG-DPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
G T +H+ A+FG+ + LL GG DP T + G P+ A +R
Sbjct: 6 GPTVLHLTARFGHPKVVNWLLHHGGGDPTAATDM-------GALPIHYAAAKGDFPSLRL 58
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L+ H E V+ A ++GA+ L+ AC +E + V +C GAD
Sbjct: 59 LVR----HYPEGVN-----AQTKNGATPLYLAC----QEGHLEVTQYLVQEC----GADP 101
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ H+ T H A G++ V+ ++ S DVS L+ Q+ G T A RGH
Sbjct: 102 HARA-HDGMTPLHAAAQMGHSPVIVWLV---SCTDVS--LSEQDKDGATATHFAASRGHS 155
Query: 943 QLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLA 1002
++++ LL + + D+ G +AL+ AAE+G L+ C L+ N A + + R+G A L+
Sbjct: 156 KVLSWLLLHGGEISA-DLWGGTALYDAAENGELECCQILVVNGAELEVRDRDGYAAADLS 214
Query: 1003 AMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAA 1037
NG++H L N ++ L + + L A
Sbjct: 215 DFNGHSHCTHCLRTVENLSMEHCVLSRDPSVELEA 249
Score = 70.9 bits (166), Expect = 4e-11
Identities = 50/161 (31%), Positives = 73/161 (45%), Gaps = 3/161 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV-DYG 121
G L L G+ +V LL + A T G +H AA + D R+LV Y
Sbjct: 6 GPTVLHLTARFGHPKVVNWLLHHGGGDPT-AATDMGALPIHYAAAKGDFPSLRLLVRHYP 64
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYG-VRANAAIADNEDRTPMHLAAENGHAAII 180
V+A G TPL++A EG + +Y A+ ++ TP+H AA+ GH+ +I
Sbjct: 65 EGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVI 124
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L S+ E+ KDG+T H A+ GH+ L G
Sbjct: 125 VWLVSCTDVSLSEQDKDGATATHFAASRGHSKVLSWLLLHG 165
Score = 61.7 bits (143), Expect = 3e-08
Identities = 46/169 (27%), Positives = 75/169 (44%), Gaps = 5/169 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV-DYG 121
G +P+ A G+ +R LL E + A T G T L+LA + +++ + LV + G
Sbjct: 40 GALPIHYAAAKGDFPSLR-LLVRHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECG 98
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVR-ANAAIADNEDRTPMHLAAENGHAAII 180
A A G TPLH AA G P++ + + + D + T H AA GH+ ++
Sbjct: 99 ADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATATHFAASRGHSKVL 158
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L G T ++ A+ NG +C +L G L + ++
Sbjct: 159 SWLL--LHGGEISADLWGGTALYDAAENGELECCQILVVNGAELEVRDR 205
Score = 57.2 bits (132), Expect = 6e-07
Identities = 55/198 (27%), Positives = 89/198 (44%), Gaps = 8/198 (4%)
Query: 923 NRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSAL--HLAAEHGYLQVCDA 980
++ NS G T L + GH ++VN LL +H D AL H AA G
Sbjct: 1 DKDNS-GPTVLHLTARFGHPKVVNWLL-HHGGGDPTAATDMGALPIHYAAAKGDFPSLRL 58
Query: 981 LLTN-KAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAAS 1039
L+ + +N++ +NG T L+LA G+ + ++L+++ A TPLH AA
Sbjct: 59 LVRHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQM 118
Query: 1040 GQIEVCKLLLE-LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNT 1098
G V L+ ++ D+ G H AA +S+V+ +L H + A G T
Sbjct: 119 GHSPVIVWLVSCTDVSLSEQDKDGATATHFAASRGHSKVLS-WLLLHGGEISADLW-GGT 176
Query: 1099 CAHIAAIQGSVKVIEELM 1116
+ AA G ++ + L+
Sbjct: 177 ALYDAAENGELECCQILV 194
Score = 56.0 bits (129), Expect = 1e-06
Identities = 39/129 (30%), Positives = 63/129 (48%), Gaps = 5/129 (3%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCK---PAVVETL 715
K G +H AR+GH ++N LL G D T + AL I + K P++ +
Sbjct: 2 KDNSGPTVLHLTARFGHPKVVNWLLHHGGG-DPTAATDMGALPIHYAAAKGDFPSLRLLV 60
Query: 716 LGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y V+ + K TPL++A + + ++ + GA P+ DGMTP+H AA+ G
Sbjct: 61 RHYPEGVNAQ-TKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMG 119
Query: 776 NLATLVLLL 784
+ +V L+
Sbjct: 120 HSPVIVWLV 128
Score = 52.8 bits (121), Expect = 1e-05
Identities = 46/162 (28%), Positives = 70/162 (43%), Gaps = 17/162 (10%)
Query: 694 NDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKS 753
N T LH+ P VV LL +G P+H AA D L++
Sbjct: 4 NSGPTVLHLTARFGHPKVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVRHY 63
Query: 754 GAGPNKATEDGMTPVHVAAKFGNL-ATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G N T++G TP+++A + G+L T L+ E G DP + +D G TPL A
Sbjct: 64 PEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARA----HD---GMTPLHAAA 116
Query: 813 RSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYA 854
+ ++ L+ S + + D+DGA+A H+A
Sbjct: 117 QMGHSPVIVWLV---------SCTDVSLSEQDKDGATATHFA 149
Score = 48.4 bits (110), Expect = 3e-04
Identities = 39/129 (30%), Positives = 59/129 (45%), Gaps = 3/129 (2%)
Query: 663 GARSIHTAARYGHVGIINTLLQK-GESVDVTTNDNYTALHIAVESCKPAVVETLLGY-GA 720
GA IH AA G + L++ E V+ T + T L++A + V + L+ GA
Sbjct: 40 GALPIHYAAAKGDFPSLRLLVRHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGA 99
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
D H R TPLH AA++ ++ + ++ +DG T H AA G+ L
Sbjct: 100 DPHARA-HDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATATHFAASRGHSKVL 158
Query: 781 VLLLEDGGD 789
LL GG+
Sbjct: 159 SWLLLHGGE 167
Score = 47.6 bits (108), Expect = 5e-04
Identities = 31/95 (32%), Positives = 46/95 (48%), Gaps = 4/95 (4%)
Query: 1310 DRHGKTGLHIASTHGHYQMVEVLL--GQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
D G T LH+ + GH ++V LL G G ATD G P+H AA G ++LL
Sbjct: 3 DNSGPTVLHLTARFGHPKVVNWLLHHGGGDPTAATDM-GALPIHYAAAKGDFPSLRLLVR 61
Query: 1368 S-GASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
++T P++ A E H +V +YL+ +
Sbjct: 62 HYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQE 96
Score = 47.6 bits (108), Expect = 5e-04
Identities = 42/158 (26%), Positives = 67/158 (42%), Gaps = 4/158 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL LA + G+ + + L+ A+ A G T LH AA+ + LV
Sbjct: 72 KNGATPLYLACQEGHLEVTQYLVQECGADP-HARAHDGMTPLHAAAQMGHSPVIVWLVSC 130
Query: 121 GAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
V + + G T H AA+ G ++ + + AD T ++ AAENG
Sbjct: 131 TDVSLSEQDKDGATATHFAASRGHSKVLSWLL-LHGGEISADLWGGTALYDAAENGELEC 189
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
++L A + R +DG ++ NGH+ C L
Sbjct: 190 CQILVVN-GAELEVRDRDGYAAADLSDFNGHSHCTHCL 226
>AL021920-3|CAI19632.1| 671|Homo sapiens espin pseudogene protein.
Length = 671
Score = 98.7 bits (235), Expect = 2e-19
Identities = 77/245 (31%), Positives = 115/245 (46%), Gaps = 6/245 (2%)
Query: 959 DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN-GRTALHLAAMNGYAHLVKFLIRD 1017
D G + LHL A G+ +V + LL + + A + G +H AA G ++ L+R
Sbjct: 3 DNSGPTVLHLTARFGHPKVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVRH 62
Query: 1018 HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLL-ELGANIDATDELGQKPIHAAAQNNYSE 1076
+ ++ T TPL+LA G +EV + L+ E GA+ A G P+HAAAQ +S
Sbjct: 63 YPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSP 122
Query: 1077 VVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPL 1136
V+ + + KDG T H AA +G KV+ L+ G ISA L T L
Sbjct: 123 VIVWLVSCTDVSLSEQDKDGATATHFAASRGHSKVLSWLLLHG--GEISA--DLWGGTAL 178
Query: 1137 QLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
AAE G + ++LV GA +R G A L+ +GH++ +R+ L +
Sbjct: 179 YDAAENGELECCQILVVNGAELEVRDRDGYAAADLSDFNGHSHCTHCLRTVENLSMEHCV 238
Query: 1197 LGLTP 1201
L P
Sbjct: 239 LSRDP 243
Score = 97.1 bits (231), Expect = 6e-19
Identities = 65/212 (30%), Positives = 107/212 (50%), Gaps = 15/212 (7%)
Query: 1160 DENRAGLTAVHLAAEHGHTNVLD-VMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
D++ +G T +HL A GH V++ ++ ++ +G P+H AA G ++R L+
Sbjct: 1 DKDNSGPTVLHLTARFGHPKVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 60
Query: 1219 SHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNEN 1278
H P V ++ ++G TPL+LA G+ V + L+ G A +++
Sbjct: 61 RHYPEGVNAQT------------KNGATPLYLACQEGHLEVTQYLVQECGADPHARAHD- 107
Query: 1279 GYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAE 1338
G PLH A GH ++ L+S + L D+ G T H A++ GH +++ LL G E
Sbjct: 108 GMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATATHFAASRGHSKVLSWLLLHGGE 167
Query: 1339 INATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
I+A D G T L+ AA+ G L ++L +GA
Sbjct: 168 ISA-DLWGGTALYDAAENGELECCQILVVNGA 198
Score = 80.2 bits (189), Expect = 7e-14
Identities = 61/190 (32%), Positives = 96/190 (50%), Gaps = 5/190 (2%)
Query: 1031 TPLHLAAASGQIEVCKLLLELGA-NIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
T LHL A G +V LL G + A ++G PIH AA ++L ++ +P V
Sbjct: 8 TVLHLTARFGHPKVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVRHYPEGV 67
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVR 1149
A TK+G T ++A +G ++V + L++ G + TPL AA+ GH+ V+
Sbjct: 68 NAQTKNGATPLYLACQEGHLEVTQYLVQ--ECGADPHARAHDGMTPLHAAAQMGHSPVIV 125
Query: 1150 VLVR-AGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYY 1208
LV S +++++ G TA H AA GH+ VL + + IS+ G T L+ AA
Sbjct: 126 WLVSCTDVSLSEQDKDGATATHFAASRGHSKVLSWL-LLHGGEISADLWGGTALYDAAEN 184
Query: 1209 GQAETVRELL 1218
G+ E + L+
Sbjct: 185 GELECCQILV 194
Score = 77.0 bits (181), Expect = 7e-13
Identities = 78/275 (28%), Positives = 126/275 (45%), Gaps = 32/275 (11%)
Query: 764 GMTPVHVAAKFGNLATLVLLLEDGG-DPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRH 822
G T +H+ A+FG+ + LL GG DP T + G P+ A +R
Sbjct: 6 GPTVLHLTARFGHPKVVNWLLHHGGGDPTAATDM-------GALPIHYAAAKGDFPSLRL 58
Query: 823 LIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADV 882
L+ H E V+ A ++GA+ L+ AC +E + V +C GAD
Sbjct: 59 LVR----HYPEGVN-----AQTKNGATPLYLAC----QEGHLEVTQYLVQEC----GADP 101
Query: 883 SLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHM 942
+ H+ T H A G++ V+ ++ S DVS L+ Q+ G T A RGH
Sbjct: 102 HARA-HDGMTPLHAAAQMGHSPVIVWLV---SCTDVS--LSEQDKDGATATHFAASRGHS 155
Query: 943 QLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLA 1002
++++ LL + + D+ G +AL+ AAE+G L+ C L+ N A + + R+G A L+
Sbjct: 156 KVLSWLLLHGGEISA-DLWGGTALYDAAENGELECCQILVVNGAELEVRDRDGYAAADLS 214
Query: 1003 AMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAA 1037
NG++H L N ++ L + + L A
Sbjct: 215 DFNGHSHCTHCLRTVENLSMEHCVLSRDPSVELEA 249
Score = 70.9 bits (166), Expect = 4e-11
Identities = 50/161 (31%), Positives = 73/161 (45%), Gaps = 3/161 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV-DYG 121
G L L G+ +V LL + A T G +H AA + D R+LV Y
Sbjct: 6 GPTVLHLTARFGHPKVVNWLLHHGGGDPT-AATDMGALPIHYAAAKGDFPSLRLLVRHYP 64
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYG-VRANAAIADNEDRTPMHLAAENGHAAII 180
V+A G TPL++A EG + +Y A+ ++ TP+H AA+ GH+ +I
Sbjct: 65 EGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVI 124
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L S+ E+ KDG+T H A+ GH+ L G
Sbjct: 125 VWLVSCTDVSLSEQDKDGATATHFAASRGHSKVLSWLLLHG 165
Score = 61.7 bits (143), Expect = 3e-08
Identities = 46/169 (27%), Positives = 75/169 (44%), Gaps = 5/169 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV-DYG 121
G +P+ A G+ +R LL E + A T G T L+LA + +++ + LV + G
Sbjct: 40 GALPIHYAAAKGDFPSLR-LLVRHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECG 98
Query: 122 AVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVR-ANAAIADNEDRTPMHLAAENGHAAII 180
A A G TPLH AA G P++ + + + D + T H AA GH+ ++
Sbjct: 99 ADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATATHFAASRGHSKVL 158
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L G T ++ A+ NG +C +L G L + ++
Sbjct: 159 SWLL--LHGGEISADLWGGTALYDAAENGELECCQILVVNGAELEVRDR 205
Score = 57.2 bits (132), Expect = 6e-07
Identities = 55/198 (27%), Positives = 89/198 (44%), Gaps = 8/198 (4%)
Query: 923 NRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSAL--HLAAEHGYLQVCDA 980
++ NS G T L + GH ++VN LL +H D AL H AA G
Sbjct: 1 DKDNS-GPTVLHLTARFGHPKVVNWLL-HHGGGDPTAATDMGALPIHYAAAKGDFPSLRL 58
Query: 981 LLTN-KAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAAS 1039
L+ + +N++ +NG T L+LA G+ + ++L+++ A TPLH AA
Sbjct: 59 LVRHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQM 118
Query: 1040 GQIEVCKLLLE-LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNT 1098
G V L+ ++ D+ G H AA +S+V+ +L H + A G T
Sbjct: 119 GHSPVIVWLVSCTDVSLSEQDKDGATATHFAASRGHSKVLS-WLLLHGGEISADLW-GGT 176
Query: 1099 CAHIAAIQGSVKVIEELM 1116
+ AA G ++ + L+
Sbjct: 177 ALYDAAENGELECCQILV 194
Score = 56.0 bits (129), Expect = 1e-06
Identities = 39/129 (30%), Positives = 63/129 (48%), Gaps = 5/129 (3%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCK---PAVVETL 715
K G +H AR+GH ++N LL G D T + AL I + K P++ +
Sbjct: 2 KDNSGPTVLHLTARFGHPKVVNWLLHHGGG-DPTAATDMGALPIHYAAAKGDFPSLRLLV 60
Query: 716 LGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y V+ + K TPL++A + + ++ + GA P+ DGMTP+H AA+ G
Sbjct: 61 RHYPEGVNAQ-TKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMG 119
Query: 776 NLATLVLLL 784
+ +V L+
Sbjct: 120 HSPVIVWLV 128
Score = 52.8 bits (121), Expect = 1e-05
Identities = 46/162 (28%), Positives = 70/162 (43%), Gaps = 17/162 (10%)
Query: 694 NDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKS 753
N T LH+ P VV LL +G P+H AA D L++
Sbjct: 4 NSGPTVLHLTARFGHPKVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVRHY 63
Query: 754 GAGPNKATEDGMTPVHVAAKFGNL-ATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G N T++G TP+++A + G+L T L+ E G DP + +D G TPL A
Sbjct: 64 PEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARA----HD---GMTPLHAAA 116
Query: 813 RSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYA 854
+ ++ L+ S + + D+DGA+A H+A
Sbjct: 117 QMGHSPVIVWLV---------SCTDVSLSEQDKDGATATHFA 149
Score = 48.4 bits (110), Expect = 3e-04
Identities = 39/129 (30%), Positives = 59/129 (45%), Gaps = 3/129 (2%)
Query: 663 GARSIHTAARYGHVGIINTLLQK-GESVDVTTNDNYTALHIAVESCKPAVVETLLGY-GA 720
GA IH AA G + L++ E V+ T + T L++A + V + L+ GA
Sbjct: 40 GALPIHYAAAKGDFPSLRLLVRHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGA 99
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
D H R TPLH AA++ ++ + ++ +DG T H AA G+ L
Sbjct: 100 DPHARA-HDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATATHFAASRGHSKVL 158
Query: 781 VLLLEDGGD 789
LL GG+
Sbjct: 159 SWLLLHGGE 167
Score = 47.6 bits (108), Expect = 5e-04
Identities = 31/95 (32%), Positives = 46/95 (48%), Gaps = 4/95 (4%)
Query: 1310 DRHGKTGLHIASTHGHYQMVEVLL--GQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
D G T LH+ + GH ++V LL G G ATD G P+H AA G ++LL
Sbjct: 3 DNSGPTVLHLTARFGHPKVVNWLLHHGGGDPTAATDM-GALPIHYAAAKGDFPSLRLLVR 61
Query: 1368 S-GASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
++T P++ A E H +V +YL+ +
Sbjct: 62 HYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQE 96
Score = 47.6 bits (108), Expect = 5e-04
Identities = 42/158 (26%), Positives = 67/158 (42%), Gaps = 4/158 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G PL LA + G+ + + L+ A+ A G T LH AA+ + LV
Sbjct: 72 KNGATPLYLACQEGHLEVTQYLVQECGADP-HARAHDGMTPLHAAAQMGHSPVIVWLVSC 130
Query: 121 GAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI 179
V + + G T H AA+ G ++ + + AD T ++ AAENG
Sbjct: 131 TDVSLSEQDKDGATATHFAASRGHSKVLSWLL-LHGGEISADLWGGTALYDAAENGELEC 189
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
++L A + R +DG ++ NGH+ C L
Sbjct: 190 CQILVVN-GAELEVRDRDGYAAADLSDFNGHSHCTHCL 226
>BX005460-4|CAM26150.1| 297|Homo sapiens euchromatic histone-lysine
N-methyltransferase 2 protein.
Length = 297
Score = 98.3 bits (234), Expect = 3e-19
Identities = 72/223 (32%), Positives = 112/223 (50%), Gaps = 16/223 (7%)
Query: 1029 KQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNL 1088
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++ Q
Sbjct: 2 KRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YMVQRGGC 60
Query: 1089 VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKL---------NDS---TPL 1136
V + +DG+TC H AA G+++++ L+ + V +A+ +L DS TP+
Sbjct: 61 VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQGQLPPPSLPSHPQDSGGWTPI 119
Query: 1137 QLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
AAE H +V+R+L+ GA T + +H A+ G + +V+ + +
Sbjct: 120 IWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNY 179
Query: 1197 LGLTPLHIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
G TPLHIAA + V LS P E T L P
Sbjct: 180 HGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 222
Score = 87.0 bits (206), Expect = 6e-16
Identities = 68/216 (31%), Positives = 102/216 (47%), Gaps = 4/216 (1%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
TPL AA+ G ++ VL++AGA+ ++ T + A + H V M S
Sbjct: 4 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 63
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESG-LTPLHLAA 1252
++ G T LH AA G E V LLS V ++ +P +SG TP+ AA
Sbjct: 64 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPSHPQDSGGWTPIIWAA 123
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
+ + V+R+LL + G NE LH A F G +I +LL+ +L H+ + H
Sbjct: 124 EHKHIEVIRMLL-TRGADVTLTDNEENIC-LHWASFTGSAAIAEVLLNARCDL-HAVNYH 180
Query: 1313 GKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWT 1348
G T LHIA+ ++ V + L +GA +K G T
Sbjct: 181 GDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 216
Score = 78.2 bits (184), Expect = 3e-13
Identities = 65/226 (28%), Positives = 109/226 (48%), Gaps = 19/226 (8%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 3 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 61
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDEL-------------GQKPIHA 1068
T LH AA G +E+ LLL G +++A +L G PI
Sbjct: 62 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPSHPQDSGGWTPIIW 121
Query: 1069 AAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
AA++ + EV+++ L + ++ + T + N C H A+ GS + E L+ + + A N
Sbjct: 122 AAEHKHIEVIRMLLTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVN 178
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
D TPL +AA + D V + + GA+ N+ G TA L E
Sbjct: 179 YHGD-TPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 223
Score = 68.9 bits (161), Expect = 2e-10
Identities = 63/219 (28%), Positives = 96/219 (43%), Gaps = 26/219 (11%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 4 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 62
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS----------- 1275
S+ E G T LH AA GN +V LLL++ V +A
Sbjct: 63 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPSHP 110
Query: 1276 -NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG 1334
+ G+ P+ A H+ ++ +LL+R A++ TD LH AS G + EVLL
Sbjct: 111 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLN 169
Query: 1335 QGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPK 1373
+++A + +G TPLH AA+ + + V L GA+P+
Sbjct: 170 ARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPE 208
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 122 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 180
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 181 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 239
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 240 GVGNRAIRTEKIICRDVARGYENVPIPC 267
Score = 64.5 bits (150), Expect = 4e-09
Identities = 49/177 (27%), Positives = 80/177 (45%), Gaps = 17/177 (9%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 4 TPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQRGG-C 60
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINAT-------------DKNGWTPLH 1351
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+
Sbjct: 61 VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPSHPQDSGGWTPII 120
Query: 1352 CAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
AA+ H+ V+++L GA N + +A+ + E LL+ D ++
Sbjct: 121 WAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 177
Score = 59.7 bits (138), Expect = 1e-07
Identities = 45/160 (28%), Positives = 73/160 (45%), Gaps = 12/160 (7%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADV---------SR 920
+V + +++ G V + T H+ A GN + M ++ DV S
Sbjct: 49 EVARYMVQRGGCV-YSKEEDGSTCLHHAAKIGNLE-MVSLLLSTGQVDVNAQGQLPPPSL 106
Query: 921 ALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDA 980
+ Q+S GWTP++ A H++++ LLT A V + D E LH A+ G + +
Sbjct: 107 PSHPQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEV 166
Query: 981 LLTNKAFINSKARNGRTALHLAAMNGYAHLV-KFLIRDHN 1019
LL + +++ +G T LH+AA Y V FL R N
Sbjct: 167 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGAN 206
Score = 56.8 bits (131), Expect = 8e-07
Identities = 49/207 (23%), Positives = 97/207 (46%), Gaps = 16/207 (7%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALL-TNKAFIN 989
TPL+ A H+++ ++ V + +G + LH AA+ G L++ LL T + +N
Sbjct: 37 TPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVN 96
Query: 990 SKAR-------------NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLA 1036
++ + G T + AA + + +++ L+ A + + ++ LH A
Sbjct: 97 AQGQLPPPSLPSHPQDSGGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEENICLHWA 155
Query: 1037 AASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDG 1096
+ +G + ++LL ++ A + G P+H AA+ +Y + V LFL + N + K+G
Sbjct: 156 SFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPEL-RNKEG 214
Query: 1097 NTCAHIAAIQGSVKVIEELMKFDRTGV 1123
+T + + V +L + R GV
Sbjct: 215 DTAWDLTPERSDVWFALQLNRKLRLGV 241
Score = 53.6 bits (123), Expect = 7e-06
Identities = 46/185 (24%), Positives = 84/185 (45%), Gaps = 17/185 (9%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 31 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 88
Query: 119 DYGAV-VDA-------------TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED 164
G V V+A + G TP+ AA +++ A+ + DNE+
Sbjct: 89 STGQVDVNAQGQLPPPSLPSHPQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEE 148
Query: 165 RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
+H A+ G AAI E+L + + + G T +HIA+ + DC ++ +G
Sbjct: 149 NICLHWASFTGSAAIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 207
Query: 225 HMPNK 229
+ NK
Sbjct: 208 ELRNK 212
Score = 52.4 bits (120), Expect = 2e-05
Identities = 58/213 (27%), Positives = 91/213 (42%), Gaps = 29/213 (13%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 4 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 50
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRS-------AEL------L 1306
R ++ G + E+G LH A G++ +V LLLS +L
Sbjct: 51 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPS 108
Query: 1307 HSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
H D G T + A+ H H +++ +LL +GA++ TD LH A+ G + ++L
Sbjct: 109 HPQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLL 168
Query: 1367 ESGASPKSETNLNCAPIWFAASENHND-VLEYL 1398
+ + P+ AA E+++D VL +L
Sbjct: 169 NARCDLHAVNYHGDTPLHIAARESYHDCVLLFL 201
Score = 50.0 bits (114), Expect = 9e-05
Identities = 25/90 (27%), Positives = 42/90 (46%), Gaps = 1/90 (1%)
Query: 132 QTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASI 191
+TPLH AA +G + AN D + RTP+ A N H + + + +
Sbjct: 3 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCV 61
Query: 192 FERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + +DGST +H A+ G+ + +L G
Sbjct: 62 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 91
Score = 45.6 bits (103), Expect = 0.002
Identities = 28/86 (32%), Positives = 41/86 (47%)
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPK 1373
+T LH A+ G ++ VLL GA INA DK TPL A HL V + + + G
Sbjct: 3 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 62
Query: 1374 SETNLNCAPIWFAASENHNDVLEYLL 1399
S+ + AA + +++ LL
Sbjct: 63 SKEEDGSTCLHHAAKIGNLEMVSLLL 88
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 4 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 61
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 62 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 91
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 115 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 172
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 173 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 232
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 233 LNRKLRLGVGNR 244
Score = 40.3 bits (90), Expect = 0.072
Identities = 25/85 (29%), Positives = 43/85 (50%), Gaps = 2/85 (2%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T LH AA++ V++ +L+ GA ++A + +TPL A + +Y R
Sbjct: 4 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVY 62
Query: 160 ADNED-RTPMHLAAENGHAAIIELL 183
+ ED T +H AA+ G+ ++ LL
Sbjct: 63 SKEEDGSTCLHHAAKIGNLEMVSLL 87
Score = 34.7 bits (76), Expect = 3.6
Identities = 25/84 (29%), Positives = 42/84 (50%), Gaps = 1/84 (1%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 6 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK- 64
Query: 727 GKQRETPLHIAARIPDGDKCALML 750
+ T LH AA+I + + +L+L
Sbjct: 65 EEDGSTCLHHAAKIGNLEMVSLLL 88
>BC011608-1|AAH11608.2| 716|Homo sapiens EHMT1 protein protein.
Length = 716
Score = 98.3 bits (234), Expect = 3e-19
Identities = 73/227 (32%), Positives = 111/227 (48%), Gaps = 21/227 (9%)
Query: 1131 NDSTPLQLAAEGGHADVVRVLVRAGA---SCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
N +PL AAE GH D+ +LV+AGA +C+++ R T + AAE+ H + +
Sbjct: 190 NKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQR---TPLMEAAENNHLEAVKYLIKA 246
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
L G T LH+AA G E V+ LLS+ V + + G TP
Sbjct: 247 GALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQ------------DDGGWTP 294
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
+ A + ++V+LLL S G + NE LH A F G + I +LL+ + LH
Sbjct: 295 MIWATEYKHVDLVKLLL-SKGSDINIRDNEENI-CLHWAAFSGCVDIAEILLAAKCD-LH 351
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
+ + HG + LHIA+ Y V + L + +++ +K G TPL CA+
Sbjct: 352 AVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 398
Score = 94.3 bits (224), Expect = 4e-18
Identities = 60/193 (31%), Positives = 104/193 (53%), Gaps = 7/193 (3%)
Query: 1029 KQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNL 1088
K++PLH AA +G +++C +L++ GANID E + P+ AA+NN+ E V+ +L + L
Sbjct: 191 KRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVK-YLIKAGAL 249
Query: 1089 VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDS--TPLQLAAEGGHAD 1146
V +G+TC H+AA +G +V++ L+ + V N +D TP+ A E H D
Sbjct: 250 VDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDV----NCQDDGGWTPMIWATEYKHVD 305
Query: 1147 VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
+V++L+ G+ + +H AA G ++ +++ + + G +PLHIAA
Sbjct: 306 LVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAA 365
Query: 1207 YYGQAETVRELLS 1219
+ + V LS
Sbjct: 366 RENRYDCVVLFLS 378
Score = 91.1 bits (216), Expect = 4e-17
Identities = 66/214 (30%), Positives = 110/214 (51%), Gaps = 10/214 (4%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
RS LH AAE G++ +C L+ A I++ + + RT L AA N + VK+LI+ A++
Sbjct: 192 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIK-AGALV 250
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
D + T LHLAA G EV + LL G +++ D+ G P+ A + + ++V+L
Sbjct: 251 DPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 310
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM--KFDRTGVISARNKLNDSTPLQLA 1139
L + ++ + ++ N C H AA G V + E L+ K D V ++ +PL +A
Sbjct: 311 LSKGSDINIRDNEE-NICLHWAAFSGCVDIAEILLAAKCDLHAV-----NIHGDSPLHIA 364
Query: 1140 AEGGHADVVRVLVRAGASCTDENRAGLTAVHLAA 1173
A D V + + + T +N+ G T + A+
Sbjct: 365 ARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 398
Score = 86.2 bits (204), Expect = 1e-15
Identities = 54/164 (32%), Positives = 83/164 (50%), Gaps = 4/164 (2%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
+PLH AA G+ ++ +L+ AG D S E+ PL A H+ V L+ A L
Sbjct: 193 SPLHAAAEAGHVDICHMLVQ-AGANIDTCS-EDQRTPLMEAAENNHLEAVKYLIKAGA-L 249
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGA-EINATDKNGWTPLHCAAKAGHLNVVKL 1364
+ D G T LH+A+ GHY++V+ LL G ++N D GWTP+ A + H+++VKL
Sbjct: 250 VDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKL 309
Query: 1365 LCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
L G+ N + +AA D+ E LL + D ++
Sbjct: 310 LLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAV 353
Score = 79.4 bits (187), Expect = 1e-13
Identities = 56/210 (26%), Positives = 102/210 (48%), Gaps = 4/210 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
+PL A GH+ + + L+ A +D + R+ L AAE+ +L+ L+ A ++
Sbjct: 193 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDP 252
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K G T LHLAA G+ +V++L+ + ++ TP+ A +++ KLLL
Sbjct: 253 KDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLS 312
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
G++I+ D +H AA + ++ ++ L +L A G++ HIAA +
Sbjct: 313 KGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDL-HAVNIHGDSPLHIAARENRYD 371
Query: 1111 VIEELMKFDRTGVISARNKLNDSTPLQLAA 1140
+ ++ R ++ +NK TPLQ A+
Sbjct: 372 CV--VLFLSRDSDVTLKNK-EGETPLQCAS 398
Score = 74.5 bits (175), Expect = 4e-12
Identities = 67/247 (27%), Positives = 113/247 (45%), Gaps = 6/247 (2%)
Query: 966 LHLAAEHGYLQVCDALLTNKAFINSKA--RNGRTALHLAAMNGYAHLVKFLIRDHNAMID 1023
L+ +A G LQ +L + N K +N R+ LH AA G+ + L++ A ID
Sbjct: 160 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQA-GANID 218
Query: 1024 VLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
+ ++TPL AA + +E K L++ GA +D D G +H AA+ + EVVQ +L
Sbjct: 219 TCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQ-YLL 277
Query: 1084 QHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGG 1143
+ + + DG I A + + +L+ + I+ R+ ++ L AA G
Sbjct: 278 SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL-LSKGSDINIRDN-EENICLHWAAFSG 335
Query: 1144 HADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLH 1203
D+ +L+ A N G + +H+AA + + + S ++ K G TPL
Sbjct: 336 CVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQ 395
Query: 1204 IAAYYGQ 1210
A+ Q
Sbjct: 396 CASLNSQ 402
Score = 74.1 bits (174), Expect = 5e-12
Identities = 77/276 (27%), Positives = 128/276 (46%), Gaps = 33/276 (11%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++ +A+ G L ++L+L DG DP K + +PL A + DI L++
Sbjct: 160 LYFSARQGELQKVLLMLVDGIDPNFKM-----EHQNKRSPLHAAAEAGHVDICHMLVQ-- 212
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A ID ED + L A + E VK LI+ GA V +
Sbjct: 213 --------AGANIDTCSEDQRTPLMEAAENNHLEA---------VKYLIKAGALVDPKDA 255
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
T H A G+ +V+ ++++ DV N Q+ GWTP++ A H+ LV
Sbjct: 256 EG-STCLHLAAKKGHYEVVQYLLSN-GQMDV----NCQDDGGWTPMIWATEYKHVDLVKL 309
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAM-NG 1006
LL+ + +++ D E LH AA G + + + LL K +++ +G + LH+AA N
Sbjct: 310 LLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENR 369
Query: 1007 YAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQI 1042
Y +V FL RD + + + + +TPL A+ + Q+
Sbjct: 370 YDCVVLFLSRDSD--VTLKNKEGETPLQCASLNSQV 403
Score = 69.7 bits (163), Expect = 1e-10
Identities = 50/164 (30%), Positives = 79/164 (48%), Gaps = 2/164 (1%)
Query: 1241 AESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLS 1300
+E TPL AA N + V+ L+ AG D E G LHLA GH +V LLS
Sbjct: 221 SEDQRTPLMEAAENNHLEAVKYLIK-AGALVDPKDAE-GSTCLHLAAKKGHYEVVQYLLS 278
Query: 1301 RSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
++ D G T + A+ + H +V++LL +G++IN D LH AA +G ++
Sbjct: 279 NGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVD 338
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
+ ++L + + +P+ AA EN D + L ++ D
Sbjct: 339 IAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSD 382
Score = 66.9 bits (156), Expect = 7e-10
Identities = 46/158 (29%), Positives = 74/158 (46%), Gaps = 2/158 (1%)
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
L+ +A G V L+L ++N +PLH A GH+ I +L+ A +
Sbjct: 160 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGAN-ID 218
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
+ +T L A+ + H + V+ L+ GA ++ D G T LH AAK GH VV+ L
Sbjct: 219 TCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLS 278
Query: 1368 SG-ASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
+G + + P+ +A H D+++ LL K D
Sbjct: 279 NGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSD 316
Score = 62.5 bits (145), Expect = 2e-08
Identities = 48/169 (28%), Positives = 77/169 (45%), Gaps = 4/169 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
Q + PL A EAG+ + L+ Q + + T L AA ++ + L+
Sbjct: 189 QNKRSPLHAAAEAGHVDICHMLV--QAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKA 246
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFY-GVRANAAIADNEDRTPMHLAAENGHAAI 179
GA+VD + G T LH+AA +G +V+Y + + D+ TPM A E H +
Sbjct: 247 GALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDL 306
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
++LL K + I R + + +H A+ +G D A +L LH N
Sbjct: 307 VKLLLSK-GSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVN 354
Score = 60.1 bits (139), Expect = 8e-08
Identities = 45/167 (26%), Positives = 75/167 (44%), Gaps = 4/167 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL+ A E + V+ L+ A K G T LHLAA++ ++ + L+ G +
Sbjct: 225 RTPLMEAAENNHLEAVKYLIKAGALVDPKDAE--GSTCLHLAAKKGHYEVVQYLLSNGQM 282
Query: 124 -VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+ + G TP+ A LVK ++ I DNE+ +H AA +G I E+
Sbjct: 283 DVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEI 342
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L K + G + +HIA+ DC ++ + + + NK
Sbjct: 343 LLAA-KCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNK 388
Score = 56.8 bits (131), Expect = 8e-07
Identities = 49/155 (31%), Positives = 75/155 (48%), Gaps = 12/155 (7%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDN--YTALHIAVESCKPAVVETLL 716
K +G+ +H AA+ GH ++ LL G+ +DV D+ +T + A E +V+ LL
Sbjct: 253 KDAEGSTCLHLAAKKGHYEVVQYLLSNGQ-MDVNCQDDGGWTPMIWATEYKHVDLVKLLL 311
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
G+D++IR ++ LH AA D A +LL + + G +P+H+AA+
Sbjct: 312 SKGSDINIRDNEENIC-LHWAAFSGCVD-IAEILLAAKCDLHAVNIHGDSPLHIAARENR 369
Query: 777 LATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMA 811
+VL L D K K GETPLQ A
Sbjct: 370 YDCVVLFLSRDSDVTLKNK-------EGETPLQCA 397
Score = 56.0 bits (129), Expect = 1e-06
Identities = 39/133 (29%), Positives = 63/133 (47%), Gaps = 1/133 (0%)
Query: 657 KYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLL 716
K +H + +H AA GHV I + L+Q G ++D + D T L A E+ V+ L+
Sbjct: 185 KMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI 244
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
GA V + + T LH+AA+ + +L N + G TP+ A ++ +
Sbjct: 245 KAGALVDPKDA-EGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKH 303
Query: 777 LATLVLLLEDGGD 789
+ + LLL G D
Sbjct: 304 VDLVKLLLSKGSD 316
Score = 56.0 bits (129), Expect = 1e-06
Identities = 37/142 (26%), Positives = 69/142 (48%), Gaps = 6/142 (4%)
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA--S 1371
++ LH A+ GH + +L+ GA I+ ++ TPL AA+ HL VK L ++GA
Sbjct: 192 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVD 251
Query: 1372 PKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIE 1431
PK C + AA + H +V++YLL + DD + M+ + + ++ +
Sbjct: 252 PKDAEGSTC--LHLAAKKGHYEVVQYLLSNGQMDVNCQDDGG--WTPMIWATEYKHVDLV 307
Query: 1432 EFVLVSPAPVDTAAKLSNIYIN 1453
+ +L + ++ NI ++
Sbjct: 308 KLLLSKGSDINIRDNEENICLH 329
Score = 52.4 bits (120), Expect = 2e-05
Identities = 32/103 (31%), Positives = 49/103 (47%), Gaps = 2/103 (1%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
A Y HV ++ LL KG +++ N+ LH A S + E LL D+H
Sbjct: 298 ATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLH-AVNIH 356
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAA 772
++PLHIAAR D C ++ L + ++G TP+ A+
Sbjct: 357 GDSPLHIAARENRYD-CVVLFLSRDSDVTLKNKEGETPLQCAS 398
Score = 50.4 bits (115), Expect = 7e-05
Identities = 31/112 (27%), Positives = 59/112 (52%), Gaps = 3/112 (2%)
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN--ATDKNGW 1347
G ++ L++ +E H K L+ ++ G Q V ++L G + N +N
Sbjct: 134 GKETLESALIALDSEKPKKLRFHPKQ-LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKR 192
Query: 1348 TPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+PLH AA+AGH+++ +L ++GA+ + + P+ AA NH + ++YL+
Sbjct: 193 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI 244
Score = 49.2 bits (112), Expect = 2e-04
Identities = 37/158 (23%), Positives = 72/158 (45%), Gaps = 4/158 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L LA + G+ +V+ LLS + + G T + A + VD+ ++L+ G+
Sbjct: 257 GSTCLHLAAKKGHYEVVQYLLSNGQMD-VNCQDDGGWTPMIWATEYKHVDLVKLLLSKGS 315
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
++ + LH AA G + + + + + +P+H+AA EN + ++
Sbjct: 316 DINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVL 375
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
L+ ++ + K+G T + ASLN A+ + K
Sbjct: 376 FLSRDSDVTL--KNKEGETPLQCASLNSQVWSALQMSK 411
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/89 (29%), Positives = 44/89 (49%), Gaps = 3/89 (3%)
Query: 135 LHIAAAEGD--EPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIF 192
L+ +A +G+ + L+ G+ N + R+P+H AAE GH I +L + A+I
Sbjct: 160 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLV-QAGANID 218
Query: 193 ERTKDGSTLMHIASLNGHADCAMMLFKKG 221
++D T + A+ N H + L K G
Sbjct: 219 TCSEDQRTPLMEAAENNHLEAVKYLIKAG 247
>AY083210-1|AAM09024.1| 1267|Homo sapiens euchromatic histone
methyltransferase 1 protein.
Length = 1267
Score = 98.3 bits (234), Expect = 3e-19
Identities = 73/227 (32%), Positives = 111/227 (48%), Gaps = 21/227 (9%)
Query: 1131 NDSTPLQLAAEGGHADVVRVLVRAGA---SCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
N +PL AAE GH D+ +LV+AGA +C+++ R T + AAE+ H + +
Sbjct: 741 NKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQR---TPLMEAAENNHLEAVKYLIKA 797
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
L G T LH+AA G E V+ LLS+ V + + G TP
Sbjct: 798 GALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQ------------DDGGWTP 845
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
+ A + ++V+LLL S G + NE LH A F G + I +LL+ + LH
Sbjct: 846 MIWATEYKHVDLVKLLL-SKGSDINIRDNEENI-CLHWAAFSGCVDIAEILLAAKCD-LH 902
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
+ + HG + LHIA+ Y V + L + +++ +K G TPL CA+
Sbjct: 903 AVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 949
Score = 94.3 bits (224), Expect = 4e-18
Identities = 60/193 (31%), Positives = 104/193 (53%), Gaps = 7/193 (3%)
Query: 1029 KQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNL 1088
K++PLH AA +G +++C +L++ GANID E + P+ AA+NN+ E V+ +L + L
Sbjct: 742 KRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVK-YLIKAGAL 800
Query: 1089 VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDS--TPLQLAAEGGHAD 1146
V +G+TC H+AA +G +V++ L+ + V N +D TP+ A E H D
Sbjct: 801 VDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDV----NCQDDGGWTPMIWATEYKHVD 856
Query: 1147 VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
+V++L+ G+ + +H AA G ++ +++ + + G +PLHIAA
Sbjct: 857 LVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAA 916
Query: 1207 YYGQAETVRELLS 1219
+ + V LS
Sbjct: 917 RENRYDCVVLFLS 929
Score = 91.1 bits (216), Expect = 4e-17
Identities = 66/214 (30%), Positives = 110/214 (51%), Gaps = 10/214 (4%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
RS LH AAE G++ +C L+ A I++ + + RT L AA N + VK+LI+ A++
Sbjct: 743 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIK-AGALV 801
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
D + T LHLAA G EV + LL G +++ D+ G P+ A + + ++V+L
Sbjct: 802 DPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 861
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM--KFDRTGVISARNKLNDSTPLQLA 1139
L + ++ + ++ N C H AA G V + E L+ K D V ++ +PL +A
Sbjct: 862 LSKGSDINIRDNEE-NICLHWAAFSGCVDIAEILLAAKCDLHAV-----NIHGDSPLHIA 915
Query: 1140 AEGGHADVVRVLVRAGASCTDENRAGLTAVHLAA 1173
A D V + + + T +N+ G T + A+
Sbjct: 916 ARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 949
Score = 86.2 bits (204), Expect = 1e-15
Identities = 54/164 (32%), Positives = 83/164 (50%), Gaps = 4/164 (2%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
+PLH AA G+ ++ +L+ AG D S E+ PL A H+ V L+ A L
Sbjct: 744 SPLHAAAEAGHVDICHMLVQ-AGANIDTCS-EDQRTPLMEAAENNHLEAVKYLIKAGA-L 800
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGA-EINATDKNGWTPLHCAAKAGHLNVVKL 1364
+ D G T LH+A+ GHY++V+ LL G ++N D GWTP+ A + H+++VKL
Sbjct: 801 VDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKL 860
Query: 1365 LCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
L G+ N + +AA D+ E LL + D ++
Sbjct: 861 LLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAV 904
Score = 79.4 bits (187), Expect = 1e-13
Identities = 56/210 (26%), Positives = 102/210 (48%), Gaps = 4/210 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
+PL A GH+ + + L+ A +D + R+ L AAE+ +L+ L+ A ++
Sbjct: 744 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDP 803
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K G T LHLAA G+ +V++L+ + ++ TP+ A +++ KLLL
Sbjct: 804 KDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLS 863
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
G++I+ D +H AA + ++ ++ L +L A G++ HIAA +
Sbjct: 864 KGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDL-HAVNIHGDSPLHIAARENRYD 922
Query: 1111 VIEELMKFDRTGVISARNKLNDSTPLQLAA 1140
+ ++ R ++ +NK TPLQ A+
Sbjct: 923 CV--VLFLSRDSDVTLKNK-EGETPLQCAS 949
Score = 74.5 bits (175), Expect = 4e-12
Identities = 67/247 (27%), Positives = 113/247 (45%), Gaps = 6/247 (2%)
Query: 966 LHLAAEHGYLQVCDALLTNKAFINSKA--RNGRTALHLAAMNGYAHLVKFLIRDHNAMID 1023
L+ +A G LQ +L + N K +N R+ LH AA G+ + L++ A ID
Sbjct: 711 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQA-GANID 769
Query: 1024 VLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
+ ++TPL AA + +E K L++ GA +D D G +H AA+ + EVVQ +L
Sbjct: 770 TCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQ-YLL 828
Query: 1084 QHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGG 1143
+ + + DG I A + + +L+ + I+ R+ ++ L AA G
Sbjct: 829 SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL-LSKGSDINIRDN-EENICLHWAAFSG 886
Query: 1144 HADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLH 1203
D+ +L+ A N G + +H+AA + + + S ++ K G TPL
Sbjct: 887 CVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQ 946
Query: 1204 IAAYYGQ 1210
A+ Q
Sbjct: 947 CASLNSQ 953
Score = 74.1 bits (174), Expect = 5e-12
Identities = 77/276 (27%), Positives = 128/276 (46%), Gaps = 33/276 (11%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++ +A+ G L ++L+L DG DP K + +PL A + DI L++
Sbjct: 711 LYFSARQGELQKVLLMLVDGIDPNFKM-----EHQNKRSPLHAAAEAGHVDICHMLVQ-- 763
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A ID ED + L A + E VK LI+ GA V +
Sbjct: 764 --------AGANIDTCSEDQRTPLMEAAENNHLEA---------VKYLIKAGALVDPKDA 806
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
T H A G+ +V+ ++++ DV N Q+ GWTP++ A H+ LV
Sbjct: 807 EG-STCLHLAAKKGHYEVVQYLLSN-GQMDV----NCQDDGGWTPMIWATEYKHVDLVKL 860
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAM-NG 1006
LL+ + +++ D E LH AA G + + + LL K +++ +G + LH+AA N
Sbjct: 861 LLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENR 920
Query: 1007 YAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQI 1042
Y +V FL RD + + + + +TPL A+ + Q+
Sbjct: 921 YDCVVLFLSRDSD--VTLKNKEGETPLQCASLNSQV 954
Score = 69.7 bits (163), Expect = 1e-10
Identities = 50/164 (30%), Positives = 79/164 (48%), Gaps = 2/164 (1%)
Query: 1241 AESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLS 1300
+E TPL AA N + V+ L+ AG D E G LHLA GH +V LLS
Sbjct: 772 SEDQRTPLMEAAENNHLEAVKYLIK-AGALVDPKDAE-GSTCLHLAAKKGHYEVVQYLLS 829
Query: 1301 RSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
++ D G T + A+ + H +V++LL +G++IN D LH AA +G ++
Sbjct: 830 NGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVD 889
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
+ ++L + + +P+ AA EN D + L ++ D
Sbjct: 890 IAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSD 933
Score = 66.9 bits (156), Expect = 7e-10
Identities = 46/158 (29%), Positives = 74/158 (46%), Gaps = 2/158 (1%)
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
L+ +A G V L+L ++N +PLH A GH+ I +L+ A +
Sbjct: 711 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGAN-ID 769
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
+ +T L A+ + H + V+ L+ GA ++ D G T LH AAK GH VV+ L
Sbjct: 770 TCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLS 829
Query: 1368 SG-ASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
+G + + P+ +A H D+++ LL K D
Sbjct: 830 NGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSD 867
Score = 62.5 bits (145), Expect = 2e-08
Identities = 48/169 (28%), Positives = 77/169 (45%), Gaps = 4/169 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
Q + PL A EAG+ + L+ Q + + T L AA ++ + L+
Sbjct: 740 QNKRSPLHAAAEAGHVDICHMLV--QAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKA 797
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFY-GVRANAAIADNEDRTPMHLAAENGHAAI 179
GA+VD + G T LH+AA +G +V+Y + + D+ TPM A E H +
Sbjct: 798 GALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDL 857
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
++LL K + I R + + +H A+ +G D A +L LH N
Sbjct: 858 VKLLLSK-GSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVN 905
Score = 60.1 bits (139), Expect = 8e-08
Identities = 45/167 (26%), Positives = 75/167 (44%), Gaps = 4/167 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL+ A E + V+ L+ A K G T LHLAA++ ++ + L+ G +
Sbjct: 776 RTPLMEAAENNHLEAVKYLIKAGALVDPKDAE--GSTCLHLAAKKGHYEVVQYLLSNGQM 833
Query: 124 -VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+ + G TP+ A LVK ++ I DNE+ +H AA +G I E+
Sbjct: 834 DVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEI 893
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L K + G + +HIA+ DC ++ + + + NK
Sbjct: 894 LLAA-KCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNK 939
Score = 56.8 bits (131), Expect = 8e-07
Identities = 49/155 (31%), Positives = 75/155 (48%), Gaps = 12/155 (7%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDN--YTALHIAVESCKPAVVETLL 716
K +G+ +H AA+ GH ++ LL G+ +DV D+ +T + A E +V+ LL
Sbjct: 804 KDAEGSTCLHLAAKKGHYEVVQYLLSNGQ-MDVNCQDDGGWTPMIWATEYKHVDLVKLLL 862
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
G+D++IR ++ LH AA D A +LL + + G +P+H+AA+
Sbjct: 863 SKGSDINIRDNEENIC-LHWAAFSGCVD-IAEILLAAKCDLHAVNIHGDSPLHIAARENR 920
Query: 777 LATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMA 811
+VL L D K K GETPLQ A
Sbjct: 921 YDCVVLFLSRDSDVTLKNK-------EGETPLQCA 948
Score = 56.0 bits (129), Expect = 1e-06
Identities = 39/133 (29%), Positives = 63/133 (47%), Gaps = 1/133 (0%)
Query: 657 KYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLL 716
K +H + +H AA GHV I + L+Q G ++D + D T L A E+ V+ L+
Sbjct: 736 KMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI 795
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
GA V + + T LH+AA+ + +L N + G TP+ A ++ +
Sbjct: 796 KAGALVDPKDA-EGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKH 854
Query: 777 LATLVLLLEDGGD 789
+ + LLL G D
Sbjct: 855 VDLVKLLLSKGSD 867
Score = 56.0 bits (129), Expect = 1e-06
Identities = 37/142 (26%), Positives = 69/142 (48%), Gaps = 6/142 (4%)
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA--S 1371
++ LH A+ GH + +L+ GA I+ ++ TPL AA+ HL VK L ++GA
Sbjct: 743 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVD 802
Query: 1372 PKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIE 1431
PK C + AA + H +V++YLL + DD + M+ + + ++ +
Sbjct: 803 PKDAEGSTC--LHLAAKKGHYEVVQYLLSNGQMDVNCQDDGG--WTPMIWATEYKHVDLV 858
Query: 1432 EFVLVSPAPVDTAAKLSNIYIN 1453
+ +L + ++ NI ++
Sbjct: 859 KLLLSKGSDINIRDNEENICLH 880
Score = 52.4 bits (120), Expect = 2e-05
Identities = 32/103 (31%), Positives = 49/103 (47%), Gaps = 2/103 (1%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
A Y HV ++ LL KG +++ N+ LH A S + E LL D+H
Sbjct: 849 ATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLH-AVNIH 907
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAA 772
++PLHIAAR D C ++ L + ++G TP+ A+
Sbjct: 908 GDSPLHIAARENRYD-CVVLFLSRDSDVTLKNKEGETPLQCAS 949
Score = 50.4 bits (115), Expect = 7e-05
Identities = 31/112 (27%), Positives = 59/112 (52%), Gaps = 3/112 (2%)
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN--ATDKNGW 1347
G ++ L++ +E H K L+ ++ G Q V ++L G + N +N
Sbjct: 685 GKETLESALIALDSEKPKKLRFHPKQ-LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKR 743
Query: 1348 TPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+PLH AA+AGH+++ +L ++GA+ + + P+ AA NH + ++YL+
Sbjct: 744 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI 795
Score = 49.2 bits (112), Expect = 2e-04
Identities = 37/158 (23%), Positives = 72/158 (45%), Gaps = 4/158 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L LA + G+ +V+ LLS + + G T + A + VD+ ++L+ G+
Sbjct: 808 GSTCLHLAAKKGHYEVVQYLLSNGQMD-VNCQDDGGWTPMIWATEYKHVDLVKLLLSKGS 866
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
++ + LH AA G + + + + + +P+H+AA EN + ++
Sbjct: 867 DINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVL 926
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
L+ ++ + K+G T + ASLN A+ + K
Sbjct: 927 FLSRDSDVTL--KNKEGETPLQCASLNSQVWSALQMSK 962
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/89 (29%), Positives = 44/89 (49%), Gaps = 3/89 (3%)
Query: 135 LHIAAAEGD--EPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIF 192
L+ +A +G+ + L+ G+ N + R+P+H AAE GH I +L + A+I
Sbjct: 711 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLV-QAGANID 769
Query: 193 ERTKDGSTLMHIASLNGHADCAMMLFKKG 221
++D T + A+ N H + L K G
Sbjct: 770 TCSEDQRTPLMEAAENNHLEAVKYLIKAG 798
>AL671762-12|CAI18225.2| 297|Homo sapiens euchromatic histone-lysine
N-methyltransferase 2 protein.
Length = 297
Score = 98.3 bits (234), Expect = 3e-19
Identities = 72/223 (32%), Positives = 112/223 (50%), Gaps = 16/223 (7%)
Query: 1029 KQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNL 1088
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++ Q
Sbjct: 2 KRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YMVQRGGC 60
Query: 1089 VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKL---------NDS---TPL 1136
V + +DG+TC H AA G+++++ L+ + V +A+ +L DS TP+
Sbjct: 61 VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQGQLPPPSLPSHPQDSGGWTPI 119
Query: 1137 QLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
AAE H +V+R+L+ GA T + +H A+ G + +V+ + +
Sbjct: 120 IWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNY 179
Query: 1197 LGLTPLHIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
G TPLHIAA + V LS P E T L P
Sbjct: 180 HGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 222
Score = 87.0 bits (206), Expect = 6e-16
Identities = 68/216 (31%), Positives = 102/216 (47%), Gaps = 4/216 (1%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
TPL AA+ G ++ VL++AGA+ ++ T + A + H V M S
Sbjct: 4 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 63
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESG-LTPLHLAA 1252
++ G T LH AA G E V LLS V ++ +P +SG TP+ AA
Sbjct: 64 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPSHPQDSGGWTPIIWAA 123
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
+ + V+R+LL + G NE LH A F G +I +LL+ +L H+ + H
Sbjct: 124 EHKHIEVIRMLL-TRGADVTLTDNEENIC-LHWASFTGSAAIAEVLLNARCDL-HAVNYH 180
Query: 1313 GKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWT 1348
G T LHIA+ ++ V + L +GA +K G T
Sbjct: 181 GDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 216
Score = 78.2 bits (184), Expect = 3e-13
Identities = 65/226 (28%), Positives = 109/226 (48%), Gaps = 19/226 (8%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 3 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 61
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDEL-------------GQKPIHA 1068
T LH AA G +E+ LLL G +++A +L G PI
Sbjct: 62 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPSHPQDSGGWTPIIW 121
Query: 1069 AAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
AA++ + EV+++ L + ++ + T + N C H A+ GS + E L+ + + A N
Sbjct: 122 AAEHKHIEVIRMLLTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVN 178
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
D TPL +AA + D V + + GA+ N+ G TA L E
Sbjct: 179 YHGD-TPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 223
Score = 68.9 bits (161), Expect = 2e-10
Identities = 63/219 (28%), Positives = 96/219 (43%), Gaps = 26/219 (11%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 4 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 62
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS----------- 1275
S+ E G T LH AA GN +V LLL++ V +A
Sbjct: 63 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPSHP 110
Query: 1276 -NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG 1334
+ G+ P+ A H+ ++ +LL+R A++ TD LH AS G + EVLL
Sbjct: 111 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLN 169
Query: 1335 QGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPK 1373
+++A + +G TPLH AA+ + + V L GA+P+
Sbjct: 170 ARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPE 208
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 122 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 180
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 181 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 239
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 240 GVGNRAIRTEKIICRDVARGYENVPIPC 267
Score = 64.5 bits (150), Expect = 4e-09
Identities = 49/177 (27%), Positives = 80/177 (45%), Gaps = 17/177 (9%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 4 TPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQRGG-C 60
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINAT-------------DKNGWTPLH 1351
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+
Sbjct: 61 VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPSHPQDSGGWTPII 120
Query: 1352 CAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
AA+ H+ V+++L GA N + +A+ + E LL+ D ++
Sbjct: 121 WAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 177
Score = 59.7 bits (138), Expect = 1e-07
Identities = 45/160 (28%), Positives = 73/160 (45%), Gaps = 12/160 (7%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADV---------SR 920
+V + +++ G V + T H+ A GN + M ++ DV S
Sbjct: 49 EVARYMVQRGGCV-YSKEEDGSTCLHHAAKIGNLE-MVSLLLSTGQVDVNAQGQLPPPSL 106
Query: 921 ALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDA 980
+ Q+S GWTP++ A H++++ LLT A V + D E LH A+ G + +
Sbjct: 107 PSHPQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEV 166
Query: 981 LLTNKAFINSKARNGRTALHLAAMNGYAHLV-KFLIRDHN 1019
LL + +++ +G T LH+AA Y V FL R N
Sbjct: 167 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGAN 206
Score = 56.8 bits (131), Expect = 8e-07
Identities = 49/207 (23%), Positives = 97/207 (46%), Gaps = 16/207 (7%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALL-TNKAFIN 989
TPL+ A H+++ ++ V + +G + LH AA+ G L++ LL T + +N
Sbjct: 37 TPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVN 96
Query: 990 SKAR-------------NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLA 1036
++ + G T + AA + + +++ L+ A + + ++ LH A
Sbjct: 97 AQGQLPPPSLPSHPQDSGGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEENICLHWA 155
Query: 1037 AASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDG 1096
+ +G + ++LL ++ A + G P+H AA+ +Y + V LFL + N + K+G
Sbjct: 156 SFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPEL-RNKEG 214
Query: 1097 NTCAHIAAIQGSVKVIEELMKFDRTGV 1123
+T + + V +L + R GV
Sbjct: 215 DTAWDLTPERSDVWFALQLNRKLRLGV 241
Score = 53.6 bits (123), Expect = 7e-06
Identities = 46/185 (24%), Positives = 84/185 (45%), Gaps = 17/185 (9%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 31 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 88
Query: 119 DYGAV-VDA-------------TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED 164
G V V+A + G TP+ AA +++ A+ + DNE+
Sbjct: 89 STGQVDVNAQGQLPPPSLPSHPQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEE 148
Query: 165 RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
+H A+ G AAI E+L + + + G T +HIA+ + DC ++ +G
Sbjct: 149 NICLHWASFTGSAAIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 207
Query: 225 HMPNK 229
+ NK
Sbjct: 208 ELRNK 212
Score = 52.4 bits (120), Expect = 2e-05
Identities = 58/213 (27%), Positives = 91/213 (42%), Gaps = 29/213 (13%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 4 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 50
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRS-------AEL------L 1306
R ++ G + E+G LH A G++ +V LLLS +L
Sbjct: 51 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPS 108
Query: 1307 HSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
H D G T + A+ H H +++ +LL +GA++ TD LH A+ G + ++L
Sbjct: 109 HPQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLL 168
Query: 1367 ESGASPKSETNLNCAPIWFAASENHND-VLEYL 1398
+ + P+ AA E+++D VL +L
Sbjct: 169 NARCDLHAVNYHGDTPLHIAARESYHDCVLLFL 201
Score = 50.0 bits (114), Expect = 9e-05
Identities = 25/90 (27%), Positives = 42/90 (46%), Gaps = 1/90 (1%)
Query: 132 QTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASI 191
+TPLH AA +G + AN D + RTP+ A N H + + + +
Sbjct: 3 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCV 61
Query: 192 FERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + +DGST +H A+ G+ + +L G
Sbjct: 62 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 91
Score = 45.6 bits (103), Expect = 0.002
Identities = 28/86 (32%), Positives = 41/86 (47%)
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPK 1373
+T LH A+ G ++ VLL GA INA DK TPL A HL V + + + G
Sbjct: 3 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 62
Query: 1374 SETNLNCAPIWFAASENHNDVLEYLL 1399
S+ + AA + +++ LL
Sbjct: 63 SKEEDGSTCLHHAAKIGNLEMVSLLL 88
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 4 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 61
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 62 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 91
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 115 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 172
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 173 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 232
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 233 LNRKLRLGVGNR 244
Score = 40.3 bits (90), Expect = 0.072
Identities = 25/85 (29%), Positives = 43/85 (50%), Gaps = 2/85 (2%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T LH AA++ V++ +L+ GA ++A + +TPL A + +Y R
Sbjct: 4 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVY 62
Query: 160 ADNED-RTPMHLAAENGHAAIIELL 183
+ ED T +H AA+ G+ ++ LL
Sbjct: 63 SKEEDGSTCLHHAAKIGNLEMVSLL 87
Score = 34.7 bits (76), Expect = 3.6
Identities = 25/84 (29%), Positives = 42/84 (50%), Gaps = 1/84 (1%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 6 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK- 64
Query: 727 GKQRETPLHIAARIPDGDKCALML 750
+ T LH AA+I + + +L+L
Sbjct: 65 EEDGSTCLHHAAKIGNLEMVSLLL 88
>AL662834-23|CAM24991.1| 297|Homo sapiens euchromatic histone-lysine
N-methyltransferase 2 protein.
Length = 297
Score = 98.3 bits (234), Expect = 3e-19
Identities = 72/223 (32%), Positives = 112/223 (50%), Gaps = 16/223 (7%)
Query: 1029 KQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNL 1088
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++ Q
Sbjct: 2 KRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YMVQRGGC 60
Query: 1089 VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKL---------NDS---TPL 1136
V + +DG+TC H AA G+++++ L+ + V +A+ +L DS TP+
Sbjct: 61 VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQGQLPPPSLPSHPQDSGGWTPI 119
Query: 1137 QLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKK 1196
AAE H +V+R+L+ GA T + +H A+ G + +V+ + +
Sbjct: 120 IWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNY 179
Query: 1197 LGLTPLHIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
G TPLHIAA + V LS P E T L P
Sbjct: 180 HGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 222
Score = 87.0 bits (206), Expect = 6e-16
Identities = 68/216 (31%), Positives = 102/216 (47%), Gaps = 4/216 (1%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
TPL AA+ G ++ VL++AGA+ ++ T + A + H V M S
Sbjct: 4 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 63
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESG-LTPLHLAA 1252
++ G T LH AA G E V LLS V ++ +P +SG TP+ AA
Sbjct: 64 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPSHPQDSGGWTPIIWAA 123
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
+ + V+R+LL + G NE LH A F G +I +LL+ +L H+ + H
Sbjct: 124 EHKHIEVIRMLL-TRGADVTLTDNEENIC-LHWASFTGSAAIAEVLLNARCDL-HAVNYH 180
Query: 1313 GKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWT 1348
G T LHIA+ ++ V + L +GA +K G T
Sbjct: 181 GDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDT 216
Score = 78.2 bits (184), Expect = 3e-13
Identities = 65/226 (28%), Positives = 109/226 (48%), Gaps = 19/226 (8%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 3 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 61
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDEL-------------GQKPIHA 1068
T LH AA G +E+ LLL G +++A +L G PI
Sbjct: 62 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPSHPQDSGGWTPIIW 121
Query: 1069 AAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARN 1128
AA++ + EV+++ L + ++ + T + N C H A+ GS + E L+ + + A N
Sbjct: 122 AAEHKHIEVIRMLLTRGADVTL-TDNEENICLHWASFTGSAAIAEVLL--NARCDLHAVN 178
Query: 1129 KLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
D TPL +AA + D V + + GA+ N+ G TA L E
Sbjct: 179 YHGD-TPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 223
Score = 68.9 bits (161), Expect = 2e-10
Identities = 63/219 (28%), Positives = 96/219 (43%), Gaps = 26/219 (11%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 4 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 62
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAAS----------- 1275
S+ E G T LH AA GN +V LLL++ V +A
Sbjct: 63 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPSHP 110
Query: 1276 -NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG 1334
+ G+ P+ A H+ ++ +LL+R A++ TD LH AS G + EVLL
Sbjct: 111 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVT-LTDNEENICLHWASFTGSAAIAEVLLN 169
Query: 1335 QGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPK 1373
+++A + +G TPLH AA+ + + V L GA+P+
Sbjct: 170 ARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPE 208
Score = 64.9 bits (151), Expect = 3e-09
Identities = 47/148 (31%), Positives = 65/148 (43%), Gaps = 7/148 (4%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA + H+ +I LL +G V +T N+ LH A + A+ E LL D+H
Sbjct: 122 AAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLH-AVNYH 180
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDG-----MTPVHVAAKFGNLATLVLLL 784
+TPLHIAAR D C L+ L GA P ++G +TP F L L
Sbjct: 181 GDTPLHIAARESYHD-CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRL 239
Query: 785 EDGGDPLRKTKVCIYDVVTGETPLQMAC 812
G +R K+ DV G + + C
Sbjct: 240 GVGNRAIRTEKIICRDVARGYENVPIPC 267
Score = 64.5 bits (150), Expect = 4e-09
Identities = 49/177 (27%), Positives = 80/177 (45%), Gaps = 17/177 (9%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
TPLH AA G+ + +LL AG +A + PL A H+ + ++ R
Sbjct: 4 TPLHAAAQKGSVEICHVLLQ-AGANINAVDKQQR-TPLMEAVVNNHLEVARYMVQRGG-C 60
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQG-AEINAT-------------DKNGWTPLH 1351
++S + G T LH A+ G+ +MV +LL G ++NA D GWTP+
Sbjct: 61 VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPSHPQDSGGWTPII 120
Query: 1352 CAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
AA+ H+ V+++L GA N + +A+ + E LL+ D ++
Sbjct: 121 WAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAV 177
Score = 59.7 bits (138), Expect = 1e-07
Identities = 45/160 (28%), Positives = 73/160 (45%), Gaps = 12/160 (7%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADV---------SR 920
+V + +++ G V + T H+ A GN + M ++ DV S
Sbjct: 49 EVARYMVQRGGCV-YSKEEDGSTCLHHAAKIGNLE-MVSLLLSTGQVDVNAQGQLPPPSL 106
Query: 921 ALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDA 980
+ Q+S GWTP++ A H++++ LLT A V + D E LH A+ G + +
Sbjct: 107 PSHPQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEV 166
Query: 981 LLTNKAFINSKARNGRTALHLAAMNGYAHLV-KFLIRDHN 1019
LL + +++ +G T LH+AA Y V FL R N
Sbjct: 167 LLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGAN 206
Score = 56.8 bits (131), Expect = 8e-07
Identities = 49/207 (23%), Positives = 97/207 (46%), Gaps = 16/207 (7%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALL-TNKAFIN 989
TPL+ A H+++ ++ V + +G + LH AA+ G L++ LL T + +N
Sbjct: 37 TPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVN 96
Query: 990 SKAR-------------NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLA 1036
++ + G T + AA + + +++ L+ A + + ++ LH A
Sbjct: 97 AQGQLPPPSLPSHPQDSGGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEENICLHWA 155
Query: 1037 AASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDG 1096
+ +G + ++LL ++ A + G P+H AA+ +Y + V LFL + N + K+G
Sbjct: 156 SFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPEL-RNKEG 214
Query: 1097 NTCAHIAAIQGSVKVIEELMKFDRTGV 1123
+T + + V +L + R GV
Sbjct: 215 DTAWDLTPERSDVWFALQLNRKLRLGV 241
Score = 53.6 bits (123), Expect = 7e-06
Identities = 46/185 (24%), Positives = 84/185 (45%), Gaps = 17/185 (9%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 31 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 88
Query: 119 DYGAV-VDA-------------TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED 164
G V V+A + G TP+ AA +++ A+ + DNE+
Sbjct: 89 STGQVDVNAQGQLPPPSLPSHPQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEE 148
Query: 165 RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL 224
+H A+ G AAI E+L + + + G T +HIA+ + DC ++ +G
Sbjct: 149 NICLHWASFTGSAAIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANP 207
Query: 225 HMPNK 229
+ NK
Sbjct: 208 ELRNK 212
Score = 52.4 bits (120), Expect = 2e-05
Identities = 58/213 (27%), Positives = 91/213 (42%), Gaps = 29/213 (13%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 4 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 50
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRS-------AEL------L 1306
R ++ G + E+G LH A G++ +V LLLS +L
Sbjct: 51 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQGQLPPPSLPS 108
Query: 1307 HSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC 1366
H D G T + A+ H H +++ +LL +GA++ TD LH A+ G + ++L
Sbjct: 109 HPQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLL 168
Query: 1367 ESGASPKSETNLNCAPIWFAASENHND-VLEYL 1398
+ + P+ AA E+++D VL +L
Sbjct: 169 NARCDLHAVNYHGDTPLHIAARESYHDCVLLFL 201
Score = 50.0 bits (114), Expect = 9e-05
Identities = 25/90 (27%), Positives = 42/90 (46%), Gaps = 1/90 (1%)
Query: 132 QTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASI 191
+TPLH AA +G + AN D + RTP+ A N H + + + +
Sbjct: 3 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCV 61
Query: 192 FERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+ + +DGST +H A+ G+ + +L G
Sbjct: 62 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 91
Score = 45.6 bits (103), Expect = 0.002
Identities = 28/86 (32%), Positives = 41/86 (47%)
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPK 1373
+T LH A+ G ++ VLL GA INA DK TPL A HL V + + + G
Sbjct: 3 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 62
Query: 1374 SETNLNCAPIWFAASENHNDVLEYLL 1399
S+ + AA + +++ LL
Sbjct: 63 SKEEDGSTCLHHAAKIGNLEMVSLLL 88
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 4 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 61
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 62 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 91
Score = 43.6 bits (98), Expect = 0.008
Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 2/132 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G P++ A E + ++R LL+ + T + LH A+ +A +L++
Sbjct: 115 GWTPIIWAAEHKHIEVIRMLLTR--GADVTLTDNEENICLHWASFTGSAAIAEVLLNARC 172
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ A N G TPLHIAA E V F AN + + E T L E
Sbjct: 173 DLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQ 232
Query: 183 LADKFKASIFER 194
L K + + R
Sbjct: 233 LNRKLRLGVGNR 244
Score = 40.3 bits (90), Expect = 0.072
Identities = 25/85 (29%), Positives = 43/85 (50%), Gaps = 2/85 (2%)
Query: 100 TALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAI 159
T LH AA++ V++ +L+ GA ++A + +TPL A + +Y R
Sbjct: 4 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVY 62
Query: 160 ADNED-RTPMHLAAENGHAAIIELL 183
+ ED T +H AA+ G+ ++ LL
Sbjct: 63 SKEEDGSTCLHHAAKIGNLEMVSLL 87
Score = 34.7 bits (76), Expect = 3.6
Identities = 25/84 (29%), Positives = 42/84 (50%), Gaps = 1/84 (1%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 6 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK- 64
Query: 727 GKQRETPLHIAARIPDGDKCALML 750
+ T LH AA+I + + +L+L
Sbjct: 65 EEDGSTCLHHAAKIGNLEMVSLLL 88
>AL611925-3|CAH71077.1| 1267|Homo sapiens euchromatic histone-lysine
N-methyltransferase 1 protein.
Length = 1267
Score = 98.3 bits (234), Expect = 3e-19
Identities = 73/227 (32%), Positives = 111/227 (48%), Gaps = 21/227 (9%)
Query: 1131 NDSTPLQLAAEGGHADVVRVLVRAGA---SCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
N +PL AAE GH D+ +LV+AGA +C+++ R T + AAE+ H + +
Sbjct: 741 NKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQR---TPLMEAAENNHLEAVKYLIKA 797
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
L G T LH+AA G E V+ LLS+ V + + G TP
Sbjct: 798 GALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQ------------DDGGWTP 845
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
+ A + ++V+LLL S G + NE LH A F G + I +LL+ + LH
Sbjct: 846 MIWATEYKHVDLVKLLL-SKGSDINIRDNEENI-CLHWAAFSGCVDIAEILLAAKCD-LH 902
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
+ + HG + LHIA+ Y V + L + +++ +K G TPL CA+
Sbjct: 903 AVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 949
Score = 94.3 bits (224), Expect = 4e-18
Identities = 60/193 (31%), Positives = 104/193 (53%), Gaps = 7/193 (3%)
Query: 1029 KQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNL 1088
K++PLH AA +G +++C +L++ GANID E + P+ AA+NN+ E V+ +L + L
Sbjct: 742 KRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVK-YLIKAGAL 800
Query: 1089 VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDS--TPLQLAAEGGHAD 1146
V +G+TC H+AA +G +V++ L+ + V N +D TP+ A E H D
Sbjct: 801 VDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDV----NCQDDGGWTPMIWATEYKHVD 856
Query: 1147 VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
+V++L+ G+ + +H AA G ++ +++ + + G +PLHIAA
Sbjct: 857 LVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAA 916
Query: 1207 YYGQAETVRELLS 1219
+ + V LS
Sbjct: 917 RENRYDCVVLFLS 929
Score = 91.1 bits (216), Expect = 4e-17
Identities = 66/214 (30%), Positives = 110/214 (51%), Gaps = 10/214 (4%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
RS LH AAE G++ +C L+ A I++ + + RT L AA N + VK+LI+ A++
Sbjct: 743 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIK-AGALV 801
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
D + T LHLAA G EV + LL G +++ D+ G P+ A + + ++V+L
Sbjct: 802 DPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 861
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM--KFDRTGVISARNKLNDSTPLQLA 1139
L + ++ + ++ N C H AA G V + E L+ K D V ++ +PL +A
Sbjct: 862 LSKGSDINIRDNEE-NICLHWAAFSGCVDIAEILLAAKCDLHAV-----NIHGDSPLHIA 915
Query: 1140 AEGGHADVVRVLVRAGASCTDENRAGLTAVHLAA 1173
A D V + + + T +N+ G T + A+
Sbjct: 916 ARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 949
Score = 86.2 bits (204), Expect = 1e-15
Identities = 54/164 (32%), Positives = 83/164 (50%), Gaps = 4/164 (2%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
+PLH AA G+ ++ +L+ AG D S E+ PL A H+ V L+ A L
Sbjct: 744 SPLHAAAEAGHVDICHMLVQ-AGANIDTCS-EDQRTPLMEAAENNHLEAVKYLIKAGA-L 800
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGA-EINATDKNGWTPLHCAAKAGHLNVVKL 1364
+ D G T LH+A+ GHY++V+ LL G ++N D GWTP+ A + H+++VKL
Sbjct: 801 VDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKL 860
Query: 1365 LCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
L G+ N + +AA D+ E LL + D ++
Sbjct: 861 LLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAV 904
Score = 79.4 bits (187), Expect = 1e-13
Identities = 56/210 (26%), Positives = 102/210 (48%), Gaps = 4/210 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
+PL A GH+ + + L+ A +D + R+ L AAE+ +L+ L+ A ++
Sbjct: 744 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDP 803
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K G T LHLAA G+ +V++L+ + ++ TP+ A +++ KLLL
Sbjct: 804 KDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLS 863
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
G++I+ D +H AA + ++ ++ L +L A G++ HIAA +
Sbjct: 864 KGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDL-HAVNIHGDSPLHIAARENRYD 922
Query: 1111 VIEELMKFDRTGVISARNKLNDSTPLQLAA 1140
+ ++ R ++ +NK TPLQ A+
Sbjct: 923 CV--VLFLSRDSDVTLKNK-EGETPLQCAS 949
Score = 74.5 bits (175), Expect = 4e-12
Identities = 67/247 (27%), Positives = 113/247 (45%), Gaps = 6/247 (2%)
Query: 966 LHLAAEHGYLQVCDALLTNKAFINSKA--RNGRTALHLAAMNGYAHLVKFLIRDHNAMID 1023
L+ +A G LQ +L + N K +N R+ LH AA G+ + L++ A ID
Sbjct: 711 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQA-GANID 769
Query: 1024 VLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
+ ++TPL AA + +E K L++ GA +D D G +H AA+ + EVVQ +L
Sbjct: 770 TCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQ-YLL 828
Query: 1084 QHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGG 1143
+ + + DG I A + + +L+ + I+ R+ ++ L AA G
Sbjct: 829 SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL-LSKGSDINIRDN-EENICLHWAAFSG 886
Query: 1144 HADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLH 1203
D+ +L+ A N G + +H+AA + + + S ++ K G TPL
Sbjct: 887 CVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQ 946
Query: 1204 IAAYYGQ 1210
A+ Q
Sbjct: 947 CASLNSQ 953
Score = 74.1 bits (174), Expect = 5e-12
Identities = 77/276 (27%), Positives = 128/276 (46%), Gaps = 33/276 (11%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++ +A+ G L ++L+L DG DP K + +PL A + DI L++
Sbjct: 711 LYFSARQGELQKVLLMLVDGIDPNFKM-----EHQNKRSPLHAAAEAGHVDICHMLVQ-- 763
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A ID ED + L A + E VK LI+ GA V +
Sbjct: 764 --------AGANIDTCSEDQRTPLMEAAENNHLEA---------VKYLIKAGALVDPKDA 806
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
T H A G+ +V+ ++++ DV N Q+ GWTP++ A H+ LV
Sbjct: 807 EG-STCLHLAAKKGHYEVVQYLLSN-GQMDV----NCQDDGGWTPMIWATEYKHVDLVKL 860
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAM-NG 1006
LL+ + +++ D E LH AA G + + + LL K +++ +G + LH+AA N
Sbjct: 861 LLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENR 920
Query: 1007 YAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQI 1042
Y +V FL RD + + + + +TPL A+ + Q+
Sbjct: 921 YDCVVLFLSRDSD--VTLKNKEGETPLQCASLNSQV 954
Score = 69.7 bits (163), Expect = 1e-10
Identities = 50/164 (30%), Positives = 79/164 (48%), Gaps = 2/164 (1%)
Query: 1241 AESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLS 1300
+E TPL AA N + V+ L+ AG D E G LHLA GH +V LLS
Sbjct: 772 SEDQRTPLMEAAENNHLEAVKYLIK-AGALVDPKDAE-GSTCLHLAAKKGHYEVVQYLLS 829
Query: 1301 RSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
++ D G T + A+ + H +V++LL +G++IN D LH AA +G ++
Sbjct: 830 NGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVD 889
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
+ ++L + + +P+ AA EN D + L ++ D
Sbjct: 890 IAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSD 933
Score = 66.9 bits (156), Expect = 7e-10
Identities = 46/158 (29%), Positives = 74/158 (46%), Gaps = 2/158 (1%)
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
L+ +A G V L+L ++N +PLH A GH+ I +L+ A +
Sbjct: 711 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGAN-ID 769
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
+ +T L A+ + H + V+ L+ GA ++ D G T LH AAK GH VV+ L
Sbjct: 770 TCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLS 829
Query: 1368 SG-ASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
+G + + P+ +A H D+++ LL K D
Sbjct: 830 NGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSD 867
Score = 62.5 bits (145), Expect = 2e-08
Identities = 48/169 (28%), Positives = 77/169 (45%), Gaps = 4/169 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
Q + PL A EAG+ + L+ Q + + T L AA ++ + L+
Sbjct: 740 QNKRSPLHAAAEAGHVDICHMLV--QAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKA 797
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFY-GVRANAAIADNEDRTPMHLAAENGHAAI 179
GA+VD + G T LH+AA +G +V+Y + + D+ TPM A E H +
Sbjct: 798 GALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDL 857
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
++LL K + I R + + +H A+ +G D A +L LH N
Sbjct: 858 VKLLLSK-GSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVN 905
Score = 60.1 bits (139), Expect = 8e-08
Identities = 45/167 (26%), Positives = 75/167 (44%), Gaps = 4/167 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL+ A E + V+ L+ A K G T LHLAA++ ++ + L+ G +
Sbjct: 776 RTPLMEAAENNHLEAVKYLIKAGALVDPKDAE--GSTCLHLAAKKGHYEVVQYLLSNGQM 833
Query: 124 -VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+ + G TP+ A LVK ++ I DNE+ +H AA +G I E+
Sbjct: 834 DVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEI 893
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L K + G + +HIA+ DC ++ + + + NK
Sbjct: 894 LLAA-KCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNK 939
Score = 56.8 bits (131), Expect = 8e-07
Identities = 49/155 (31%), Positives = 75/155 (48%), Gaps = 12/155 (7%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDN--YTALHIAVESCKPAVVETLL 716
K +G+ +H AA+ GH ++ LL G+ +DV D+ +T + A E +V+ LL
Sbjct: 804 KDAEGSTCLHLAAKKGHYEVVQYLLSNGQ-MDVNCQDDGGWTPMIWATEYKHVDLVKLLL 862
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
G+D++IR ++ LH AA D A +LL + + G +P+H+AA+
Sbjct: 863 SKGSDINIRDNEENIC-LHWAAFSGCVD-IAEILLAAKCDLHAVNIHGDSPLHIAARENR 920
Query: 777 LATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMA 811
+VL L D K K GETPLQ A
Sbjct: 921 YDCVVLFLSRDSDVTLKNK-------EGETPLQCA 948
Score = 56.0 bits (129), Expect = 1e-06
Identities = 39/133 (29%), Positives = 63/133 (47%), Gaps = 1/133 (0%)
Query: 657 KYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLL 716
K +H + +H AA GHV I + L+Q G ++D + D T L A E+ V+ L+
Sbjct: 736 KMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI 795
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
GA V + + T LH+AA+ + +L N + G TP+ A ++ +
Sbjct: 796 KAGALVDPKDA-EGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKH 854
Query: 777 LATLVLLLEDGGD 789
+ + LLL G D
Sbjct: 855 VDLVKLLLSKGSD 867
Score = 56.0 bits (129), Expect = 1e-06
Identities = 37/142 (26%), Positives = 69/142 (48%), Gaps = 6/142 (4%)
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA--S 1371
++ LH A+ GH + +L+ GA I+ ++ TPL AA+ HL VK L ++GA
Sbjct: 743 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVD 802
Query: 1372 PKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIE 1431
PK C + AA + H +V++YLL + DD + M+ + + ++ +
Sbjct: 803 PKDAEGSTC--LHLAAKKGHYEVVQYLLSNGQMDVNCQDDGG--WTPMIWATEYKHVDLV 858
Query: 1432 EFVLVSPAPVDTAAKLSNIYIN 1453
+ +L + ++ NI ++
Sbjct: 859 KLLLSKGSDINIRDNEENICLH 880
Score = 52.4 bits (120), Expect = 2e-05
Identities = 32/103 (31%), Positives = 49/103 (47%), Gaps = 2/103 (1%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
A Y HV ++ LL KG +++ N+ LH A S + E LL D+H
Sbjct: 849 ATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLH-AVNIH 907
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAA 772
++PLHIAAR D C ++ L + ++G TP+ A+
Sbjct: 908 GDSPLHIAARENRYD-CVVLFLSRDSDVTLKNKEGETPLQCAS 949
Score = 50.4 bits (115), Expect = 7e-05
Identities = 31/112 (27%), Positives = 59/112 (52%), Gaps = 3/112 (2%)
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN--ATDKNGW 1347
G ++ L++ +E H K L+ ++ G Q V ++L G + N +N
Sbjct: 685 GKETLESALIALDSEKPKKLRFHPKQ-LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKR 743
Query: 1348 TPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+PLH AA+AGH+++ +L ++GA+ + + P+ AA NH + ++YL+
Sbjct: 744 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI 795
Score = 49.2 bits (112), Expect = 2e-04
Identities = 37/158 (23%), Positives = 72/158 (45%), Gaps = 4/158 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L LA + G+ +V+ LLS + + G T + A + VD+ ++L+ G+
Sbjct: 808 GSTCLHLAAKKGHYEVVQYLLSNGQMD-VNCQDDGGWTPMIWATEYKHVDLVKLLLSKGS 866
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
++ + LH AA G + + + + + +P+H+AA EN + ++
Sbjct: 867 DINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVL 926
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
L+ ++ + K+G T + ASLN A+ + K
Sbjct: 927 FLSRDSDVTL--KNKEGETPLQCASLNSQVWSALQMSK 962
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/89 (29%), Positives = 44/89 (49%), Gaps = 3/89 (3%)
Query: 135 LHIAAAEGD--EPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIF 192
L+ +A +G+ + L+ G+ N + R+P+H AAE GH I +L + A+I
Sbjct: 711 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLV-QAGANID 769
Query: 193 ERTKDGSTLMHIASLNGHADCAMMLFKKG 221
++D T + A+ N H + L K G
Sbjct: 770 TCSEDQRTPLMEAAENNHLEAVKYLIKAG 798
>AL590627-3|CAI17355.1| 1267|Homo sapiens euchromatic histone-lysine
N-methyltransferase 1 protein.
Length = 1267
Score = 98.3 bits (234), Expect = 3e-19
Identities = 73/227 (32%), Positives = 111/227 (48%), Gaps = 21/227 (9%)
Query: 1131 NDSTPLQLAAEGGHADVVRVLVRAGA---SCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
N +PL AAE GH D+ +LV+AGA +C+++ R T + AAE+ H + +
Sbjct: 741 NKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQR---TPLMEAAENNHLEAVKYLIKA 797
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
L G T LH+AA G E V+ LLS+ V + + G TP
Sbjct: 798 GALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQ------------DDGGWTP 845
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
+ A + ++V+LLL S G + NE LH A F G + I +LL+ + LH
Sbjct: 846 MIWATEYKHVDLVKLLL-SKGSDINIRDNEENI-CLHWAAFSGCVDIAEILLAAKCD-LH 902
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
+ + HG + LHIA+ Y V + L + +++ +K G TPL CA+
Sbjct: 903 AVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 949
Score = 94.3 bits (224), Expect = 4e-18
Identities = 60/193 (31%), Positives = 104/193 (53%), Gaps = 7/193 (3%)
Query: 1029 KQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNL 1088
K++PLH AA +G +++C +L++ GANID E + P+ AA+NN+ E V+ +L + L
Sbjct: 742 KRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVK-YLIKAGAL 800
Query: 1089 VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDS--TPLQLAAEGGHAD 1146
V +G+TC H+AA +G +V++ L+ + V N +D TP+ A E H D
Sbjct: 801 VDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDV----NCQDDGGWTPMIWATEYKHVD 856
Query: 1147 VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
+V++L+ G+ + +H AA G ++ +++ + + G +PLHIAA
Sbjct: 857 LVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAA 916
Query: 1207 YYGQAETVRELLS 1219
+ + V LS
Sbjct: 917 RENRYDCVVLFLS 929
Score = 91.1 bits (216), Expect = 4e-17
Identities = 66/214 (30%), Positives = 110/214 (51%), Gaps = 10/214 (4%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
RS LH AAE G++ +C L+ A I++ + + RT L AA N + VK+LI+ A++
Sbjct: 743 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIK-AGALV 801
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
D + T LHLAA G EV + LL G +++ D+ G P+ A + + ++V+L
Sbjct: 802 DPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 861
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM--KFDRTGVISARNKLNDSTPLQLA 1139
L + ++ + ++ N C H AA G V + E L+ K D V ++ +PL +A
Sbjct: 862 LSKGSDINIRDNEE-NICLHWAAFSGCVDIAEILLAAKCDLHAV-----NIHGDSPLHIA 915
Query: 1140 AEGGHADVVRVLVRAGASCTDENRAGLTAVHLAA 1173
A D V + + + T +N+ G T + A+
Sbjct: 916 ARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 949
Score = 86.2 bits (204), Expect = 1e-15
Identities = 54/164 (32%), Positives = 83/164 (50%), Gaps = 4/164 (2%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
+PLH AA G+ ++ +L+ AG D S E+ PL A H+ V L+ A L
Sbjct: 744 SPLHAAAEAGHVDICHMLVQ-AGANIDTCS-EDQRTPLMEAAENNHLEAVKYLIKAGA-L 800
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGA-EINATDKNGWTPLHCAAKAGHLNVVKL 1364
+ D G T LH+A+ GHY++V+ LL G ++N D GWTP+ A + H+++VKL
Sbjct: 801 VDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKL 860
Query: 1365 LCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
L G+ N + +AA D+ E LL + D ++
Sbjct: 861 LLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAV 904
Score = 79.4 bits (187), Expect = 1e-13
Identities = 56/210 (26%), Positives = 102/210 (48%), Gaps = 4/210 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
+PL A GH+ + + L+ A +D + R+ L AAE+ +L+ L+ A ++
Sbjct: 744 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDP 803
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K G T LHLAA G+ +V++L+ + ++ TP+ A +++ KLLL
Sbjct: 804 KDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLS 863
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
G++I+ D +H AA + ++ ++ L +L A G++ HIAA +
Sbjct: 864 KGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDL-HAVNIHGDSPLHIAARENRYD 922
Query: 1111 VIEELMKFDRTGVISARNKLNDSTPLQLAA 1140
+ ++ R ++ +NK TPLQ A+
Sbjct: 923 CV--VLFLSRDSDVTLKNK-EGETPLQCAS 949
Score = 74.5 bits (175), Expect = 4e-12
Identities = 67/247 (27%), Positives = 113/247 (45%), Gaps = 6/247 (2%)
Query: 966 LHLAAEHGYLQVCDALLTNKAFINSKA--RNGRTALHLAAMNGYAHLVKFLIRDHNAMID 1023
L+ +A G LQ +L + N K +N R+ LH AA G+ + L++ A ID
Sbjct: 711 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQA-GANID 769
Query: 1024 VLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
+ ++TPL AA + +E K L++ GA +D D G +H AA+ + EVVQ +L
Sbjct: 770 TCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQ-YLL 828
Query: 1084 QHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGG 1143
+ + + DG I A + + +L+ + I+ R+ ++ L AA G
Sbjct: 829 SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL-LSKGSDINIRDN-EENICLHWAAFSG 886
Query: 1144 HADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLH 1203
D+ +L+ A N G + +H+AA + + + S ++ K G TPL
Sbjct: 887 CVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQ 946
Query: 1204 IAAYYGQ 1210
A+ Q
Sbjct: 947 CASLNSQ 953
Score = 74.1 bits (174), Expect = 5e-12
Identities = 77/276 (27%), Positives = 128/276 (46%), Gaps = 33/276 (11%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++ +A+ G L ++L+L DG DP K + +PL A + DI L++
Sbjct: 711 LYFSARQGELQKVLLMLVDGIDPNFKM-----EHQNKRSPLHAAAEAGHVDICHMLVQ-- 763
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A ID ED + L A + E VK LI+ GA V +
Sbjct: 764 --------AGANIDTCSEDQRTPLMEAAENNHLEA---------VKYLIKAGALVDPKDA 806
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
T H A G+ +V+ ++++ DV N Q+ GWTP++ A H+ LV
Sbjct: 807 EG-STCLHLAAKKGHYEVVQYLLSN-GQMDV----NCQDDGGWTPMIWATEYKHVDLVKL 860
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAM-NG 1006
LL+ + +++ D E LH AA G + + + LL K +++ +G + LH+AA N
Sbjct: 861 LLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENR 920
Query: 1007 YAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQI 1042
Y +V FL RD + + + + +TPL A+ + Q+
Sbjct: 921 YDCVVLFLSRDSD--VTLKNKEGETPLQCASLNSQV 954
Score = 69.7 bits (163), Expect = 1e-10
Identities = 50/164 (30%), Positives = 79/164 (48%), Gaps = 2/164 (1%)
Query: 1241 AESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLS 1300
+E TPL AA N + V+ L+ AG D E G LHLA GH +V LLS
Sbjct: 772 SEDQRTPLMEAAENNHLEAVKYLIK-AGALVDPKDAE-GSTCLHLAAKKGHYEVVQYLLS 829
Query: 1301 RSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
++ D G T + A+ + H +V++LL +G++IN D LH AA +G ++
Sbjct: 830 NGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVD 889
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
+ ++L + + +P+ AA EN D + L ++ D
Sbjct: 890 IAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSD 933
Score = 66.9 bits (156), Expect = 7e-10
Identities = 46/158 (29%), Positives = 74/158 (46%), Gaps = 2/158 (1%)
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
L+ +A G V L+L ++N +PLH A GH+ I +L+ A +
Sbjct: 711 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGAN-ID 769
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
+ +T L A+ + H + V+ L+ GA ++ D G T LH AAK GH VV+ L
Sbjct: 770 TCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLS 829
Query: 1368 SG-ASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
+G + + P+ +A H D+++ LL K D
Sbjct: 830 NGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSD 867
Score = 62.5 bits (145), Expect = 2e-08
Identities = 48/169 (28%), Positives = 77/169 (45%), Gaps = 4/169 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
Q + PL A EAG+ + L+ Q + + T L AA ++ + L+
Sbjct: 740 QNKRSPLHAAAEAGHVDICHMLV--QAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKA 797
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFY-GVRANAAIADNEDRTPMHLAAENGHAAI 179
GA+VD + G T LH+AA +G +V+Y + + D+ TPM A E H +
Sbjct: 798 GALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDL 857
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
++LL K + I R + + +H A+ +G D A +L LH N
Sbjct: 858 VKLLLSK-GSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVN 905
Score = 60.1 bits (139), Expect = 8e-08
Identities = 45/167 (26%), Positives = 75/167 (44%), Gaps = 4/167 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL+ A E + V+ L+ A K G T LHLAA++ ++ + L+ G +
Sbjct: 776 RTPLMEAAENNHLEAVKYLIKAGALVDPKDAE--GSTCLHLAAKKGHYEVVQYLLSNGQM 833
Query: 124 -VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+ + G TP+ A LVK ++ I DNE+ +H AA +G I E+
Sbjct: 834 DVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEI 893
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L K + G + +HIA+ DC ++ + + + NK
Sbjct: 894 LLAA-KCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNK 939
Score = 56.8 bits (131), Expect = 8e-07
Identities = 49/155 (31%), Positives = 75/155 (48%), Gaps = 12/155 (7%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDN--YTALHIAVESCKPAVVETLL 716
K +G+ +H AA+ GH ++ LL G+ +DV D+ +T + A E +V+ LL
Sbjct: 804 KDAEGSTCLHLAAKKGHYEVVQYLLSNGQ-MDVNCQDDGGWTPMIWATEYKHVDLVKLLL 862
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
G+D++IR ++ LH AA D A +LL + + G +P+H+AA+
Sbjct: 863 SKGSDINIRDNEENIC-LHWAAFSGCVD-IAEILLAAKCDLHAVNIHGDSPLHIAARENR 920
Query: 777 LATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMA 811
+VL L D K K GETPLQ A
Sbjct: 921 YDCVVLFLSRDSDVTLKNK-------EGETPLQCA 948
Score = 56.0 bits (129), Expect = 1e-06
Identities = 39/133 (29%), Positives = 63/133 (47%), Gaps = 1/133 (0%)
Query: 657 KYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLL 716
K +H + +H AA GHV I + L+Q G ++D + D T L A E+ V+ L+
Sbjct: 736 KMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI 795
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
GA V + + T LH+AA+ + +L N + G TP+ A ++ +
Sbjct: 796 KAGALVDPKDA-EGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKH 854
Query: 777 LATLVLLLEDGGD 789
+ + LLL G D
Sbjct: 855 VDLVKLLLSKGSD 867
Score = 56.0 bits (129), Expect = 1e-06
Identities = 37/142 (26%), Positives = 69/142 (48%), Gaps = 6/142 (4%)
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA--S 1371
++ LH A+ GH + +L+ GA I+ ++ TPL AA+ HL VK L ++GA
Sbjct: 743 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVD 802
Query: 1372 PKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIE 1431
PK C + AA + H +V++YLL + DD + M+ + + ++ +
Sbjct: 803 PKDAEGSTC--LHLAAKKGHYEVVQYLLSNGQMDVNCQDDGG--WTPMIWATEYKHVDLV 858
Query: 1432 EFVLVSPAPVDTAAKLSNIYIN 1453
+ +L + ++ NI ++
Sbjct: 859 KLLLSKGSDINIRDNEENICLH 880
Score = 52.4 bits (120), Expect = 2e-05
Identities = 32/103 (31%), Positives = 49/103 (47%), Gaps = 2/103 (1%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
A Y HV ++ LL KG +++ N+ LH A S + E LL D+H
Sbjct: 849 ATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLH-AVNIH 907
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAA 772
++PLHIAAR D C ++ L + ++G TP+ A+
Sbjct: 908 GDSPLHIAARENRYD-CVVLFLSRDSDVTLKNKEGETPLQCAS 949
Score = 50.4 bits (115), Expect = 7e-05
Identities = 31/112 (27%), Positives = 59/112 (52%), Gaps = 3/112 (2%)
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN--ATDKNGW 1347
G ++ L++ +E H K L+ ++ G Q V ++L G + N +N
Sbjct: 685 GKETLESALIALDSEKPKKLRFHPKQ-LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKR 743
Query: 1348 TPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+PLH AA+AGH+++ +L ++GA+ + + P+ AA NH + ++YL+
Sbjct: 744 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI 795
Score = 49.2 bits (112), Expect = 2e-04
Identities = 37/158 (23%), Positives = 72/158 (45%), Gaps = 4/158 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L LA + G+ +V+ LLS + + G T + A + VD+ ++L+ G+
Sbjct: 808 GSTCLHLAAKKGHYEVVQYLLSNGQMD-VNCQDDGGWTPMIWATEYKHVDLVKLLLSKGS 866
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
++ + LH AA G + + + + + +P+H+AA EN + ++
Sbjct: 867 DINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVL 926
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
L+ ++ + K+G T + ASLN A+ + K
Sbjct: 927 FLSRDSDVTL--KNKEGETPLQCASLNSQVWSALQMSK 962
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/89 (29%), Positives = 44/89 (49%), Gaps = 3/89 (3%)
Query: 135 LHIAAAEGD--EPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIF 192
L+ +A +G+ + L+ G+ N + R+P+H AAE GH I +L + A+I
Sbjct: 711 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLV-QAGANID 769
Query: 193 ERTKDGSTLMHIASLNGHADCAMMLFKKG 221
++D T + A+ N H + L K G
Sbjct: 770 TCSEDQRTPLMEAAENNHLEAVKYLIKAG 798
>AB209433-1|BAD92670.1| 1031|Homo sapiens HLA-B associated transcript
8 BAT8 isoform a variant protein.
Length = 1031
Score = 98.3 bits (234), Expect = 3e-19
Identities = 84/284 (29%), Positives = 135/284 (47%), Gaps = 13/284 (4%)
Query: 964 SALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDH-NAMI 1022
SA+ L G + AL+ ++ K R L+L+ G V ++ D+ +
Sbjct: 433 SAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNF 492
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFL 1082
K+TPLH AA G +E+C +LL+ GANI+A D+ + P+ A NN+ EV + ++
Sbjct: 493 QSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVAR-YM 551
Query: 1083 QQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEG 1142
Q V + +DG+TC H AA G+++++ L+ + V +A++ TP+ AAE
Sbjct: 552 VQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDV-NAQDS-GGWTPIIWAAEH 609
Query: 1143 GHADVVRVLVRAGA--SCTDENRAGLT-----AVHLAAEHGHTNVLDVMRSTNTLRISSK 1195
H +V+R+L+ GA + TD L +H A+ G + +V+ + +
Sbjct: 610 KHIEVIRMLLTRGADVTLTDNVSERLVEEENICLHWASFTGSAAIAEVLLNARCDLHAVN 669
Query: 1196 KLGLTPLHIAAYYGQAETVRELLSH--VPGTVKSEAPTGVSLVP 1237
G TPLHIAA + V LS P E T L P
Sbjct: 670 YHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 713
Score = 85.4 bits (202), Expect = 2e-15
Identities = 64/219 (29%), Positives = 108/219 (49%), Gaps = 11/219 (5%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
R+ LH AA+ G +++C LL A IN+ + RT L A +N + + +++++ +
Sbjct: 500 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQ-RGGCV 558
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
T LH AA G +E+ LLL G +++A D G PI AA++ + EV+++
Sbjct: 559 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRML 618
Query: 1082 LQQHPNLVMA------TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTP 1135
L + ++ + ++ N C H A+ GS + E L+ + + A N D TP
Sbjct: 619 LTRGADVTLTDNVSERLVEEENICLHWASFTGSAAIAEVLL--NARCDLHAVNYHGD-TP 675
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
L +AA + D V + + GA+ N+ G TA L E
Sbjct: 676 LHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 714
Score = 74.9 bits (176), Expect = 3e-12
Identities = 76/255 (29%), Positives = 113/255 (44%), Gaps = 23/255 (9%)
Query: 1101 HIAAIQGSV-KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCT 1159
+++ QG + KVI LM D ++ + TPL AA+ G ++ VL++AGA+
Sbjct: 469 YLSVKQGELQKVI--LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 526
Query: 1160 DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLS 1219
++ T + A + H V M S ++ G T LH AA G E V LLS
Sbjct: 527 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 586
Query: 1220 HVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASN--- 1276
G V A G TP+ AA + + V+R+LL + G N
Sbjct: 587 --TGQVDVNAQDS----------GGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNVSE 633
Query: 1277 ---ENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLL 1333
E LH A F G +I +LL+ +L H+ + HG T LHIA+ ++ V + L
Sbjct: 634 RLVEEENICLHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIAARESYHDCVLLFL 692
Query: 1334 GQGAEINATDKNGWT 1348
+GA +K G T
Sbjct: 693 SRGANPELRNKEGDT 707
Score = 69.7 bits (163), Expect = 1e-10
Identities = 61/213 (28%), Positives = 96/213 (45%), Gaps = 20/213 (9%)
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
T +H AA+ G + V+ + K TPL A E R ++ G V
Sbjct: 501 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQR-GGCVY 559
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
S+ E G T LH AA GN +V LLL++ V +A + G+ P+ A
Sbjct: 560 SKE------------EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA-QDSGGWTPIIWA 606
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTD------RHGKTGLHIASTHGHYQMVEVLLGQGAEIN 1340
H+ ++ +LL+R A++ + + LH AS G + EVLL +++
Sbjct: 607 AEHKHIEVIRMLLTRGADVTLTDNVSERLVEEENICLHWASFTGSAAIAEVLLNARCDLH 666
Query: 1341 ATDKNGWTPLHCAAKAGHLNVVKLLCESGASPK 1373
A + +G TPLH AA+ + + V L GA+P+
Sbjct: 667 AVNYHGDTPLHIAARESYHDCVLLFLSRGANPE 699
Score = 68.9 bits (161), Expect = 2e-10
Identities = 55/210 (26%), Positives = 95/210 (45%), Gaps = 10/210 (4%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL A +G +++ + LL A ++ D + R+ L A + +L+V ++ + S
Sbjct: 501 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 560
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K +G T LH AA G +V L+ ++ TP+ AA IEV ++LL
Sbjct: 561 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 620
Query: 1051 LGANIDATDELGQKPI-------HAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIA 1103
GA++ TD + ++ + H A+ + + ++ L +L A G+T HIA
Sbjct: 621 RGADVTLTDNVSERLVEEENICLHWASFTGSAAIAEVLLNARCDL-HAVNYHGDTPLHIA 679
Query: 1104 AIQGSVKVIEELMKFDRTGVISARNKLNDS 1133
A + + L+ R RNK D+
Sbjct: 680 ARESYHDCV--LLFLSRGANPELRNKEGDT 707
Score = 60.5 bits (140), Expect = 6e-08
Identities = 67/260 (25%), Positives = 117/260 (45%), Gaps = 38/260 (14%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++++ K G L ++L+L D DP ++ D + TPL A + +I L++
Sbjct: 468 LYLSVKQGELQKVILMLLDNLDPNFQS-----DQQSKRTPLHAAAQKGSVEICHVLLQ-- 520
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A I+AVD+ + L A + +V + +++ G V
Sbjct: 521 --------AGANINAVDKQQRTPLMEA---------VVNNHLEVARYMVQRGGCV-YSKE 562
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
+ T H+ A GN ++++ ++ ST V +N Q+S GWTP++ A H++++
Sbjct: 563 EDGSTCLHHAAKIGNLEMVSLLL---STGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRM 617
Query: 948 LLTNHARVDVFD-------VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALH 1000
LLT A V + D E LH A+ G + + LL + +++ +G T LH
Sbjct: 618 LLTRGADVTLTDNVSERLVEEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLH 677
Query: 1001 LAAMNGYAHLV-KFLIRDHN 1019
+AA Y V FL R N
Sbjct: 678 IAARESYHDCVLLFLSRGAN 697
Score = 58.4 bits (135), Expect = 3e-07
Identities = 46/179 (25%), Positives = 84/179 (46%), Gaps = 11/179 (6%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V ++ + PL+ AV + + R ++ Q + + G T LH AA+ +++M +L+
Sbjct: 528 VDKQQRTPLMEAVVNNHLEVARYMV--QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 585
Query: 119 DYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADN-------EDRTPMHL 170
G V V+A + G TP+ AA +++ A+ + DN E+ +H
Sbjct: 586 STGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNVSERLVEEENICLHW 645
Query: 171 AAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
A+ G AAI E+L + + + G T +HIA+ + DC ++ +G + NK
Sbjct: 646 ASFTGSAAIAEVLLNA-RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 703
Score = 55.2 bits (127), Expect = 2e-06
Identities = 56/207 (27%), Positives = 92/207 (44%), Gaps = 23/207 (11%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV 1259
TPLH AA G E LL +A ++ V + TPL A N + V
Sbjct: 501 TPLHAAAQKGSVEICHVLL---------QAGANINAVD----KQQRTPLMEAVVNNHLEV 547
Query: 1260 VRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHI 1319
R ++ G + E+G LH A G++ +V LLLS +++ D G T +
Sbjct: 548 ARYMVQRGGCVY--SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIW 605
Query: 1320 ASTHGHYQMVEVLLGQGAEINATD-------KNGWTPLHCAAKAGHLNVVKLLCESGASP 1372
A+ H H +++ +LL +GA++ TD + LH A+ G + ++L +
Sbjct: 606 AAEHKHIEVIRMLLTRGADVTLTDNVSERLVEEENICLHWASFTGSAAIAEVLLNARCDL 665
Query: 1373 KSETNLNCAPIWFAASENHND-VLEYL 1398
+ P+ AA E+++D VL +L
Sbjct: 666 HAVNYHGDTPLHIAARESYHDCVLLFL 692
Score = 51.6 bits (118), Expect = 3e-05
Identities = 40/173 (23%), Positives = 77/173 (44%), Gaps = 2/173 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L L+V+ G V +L ++ + T LH AA++ V++ +L+ GA ++A
Sbjct: 468 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 527
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNED-RTPMHLAAENGHAAIIELLAD 185
+ +TPL A + +Y R + ED T +H AA+ G+ ++ LL
Sbjct: 528 VDKQQRTPLMEAVVNNHLEVARYMV-QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 586
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDE 238
+ + + G T + A+ + H + ML +G + + + E+ +E
Sbjct: 587 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNVSERLVEEE 639
Score = 50.8 bits (116), Expect = 5e-05
Identities = 43/167 (25%), Positives = 72/167 (43%), Gaps = 3/167 (1%)
Query: 1283 LHLACFGGHMSIVGLLLSRSAELLHSTDRHGK-TGLHIASTHGHYQMVEVLLGQGAEINA 1341
L+L+ G + V L+L + + +D+ K T LH A+ G ++ VLL GA INA
Sbjct: 468 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 527
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHK 1401
DK TPL A HL V + + + G S+ + AA + +++ LL
Sbjct: 528 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLST 587
Query: 1402 EHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAKLS 1448
+ D + ++ + H +I + +L A V +S
Sbjct: 588 GQVDVNAQDSGG--WTPIIWAAEHKHIEVIRMLLTRGADVTLTDNVS 632
Score = 48.4 bits (110), Expect = 3e-04
Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 1/123 (0%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA+ G V I + LLQ G +++ T L AV + V ++ G V+ +
Sbjct: 503 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 562
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
+ T LH AA+I + + +L+L N G TP+ AA+ ++ + +LL
Sbjct: 563 -EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 621
Query: 787 GGD 789
G D
Sbjct: 622 GAD 624
Score = 48.0 bits (109), Expect = 4e-04
Identities = 41/145 (28%), Positives = 68/145 (46%), Gaps = 10/145 (6%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDN--YTALHIAVESCKPAVVETLL 716
K DG+ +H AA+ G++ +++ LL G+ VDV D+ +T + A E V+ LL
Sbjct: 561 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQ-VDVNAQDSGGWTPIIWAAEHKHIEVIRMLL 619
Query: 717 GYGADVHIRGG------KQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHV 770
GADV + ++ LH A+ A +LL + + G TP+H+
Sbjct: 620 TRGADVTLTDNVSERLVEEENICLHWAS-FTGSAAIAEVLLNARCDLHAVNYHGDTPLHI 678
Query: 771 AAKFGNLATLVLLLEDGGDPLRKTK 795
AA+ ++L L G +P + K
Sbjct: 679 AARESYHDCVLLFLSRGANPELRNK 703
Score = 44.8 bits (101), Expect = 0.003
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 698 TALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP 757
T LH A + + LL GA+++ KQ+ TPL + A + + + A +++ G
Sbjct: 501 TPLHAAAQKGSVEICHVLLQAGANINAVD-KQQRTPL-MEAVVNNHLEVARYMVQRGGCV 558
Query: 758 NKATEDGMTPVHVAAKFGNLATLVLLLEDG 787
EDG T +H AAK GNL + LLL G
Sbjct: 559 YSKEEDGSTCLHHAAKIGNLEMVSLLLSTG 588
Score = 39.5 bits (88), Expect = 0.13
Identities = 35/137 (25%), Positives = 53/137 (38%), Gaps = 5/137 (3%)
Query: 63 GKVPLLLAVEAGNQSMVRELLS-----AQTAEQLKATTPAGDTALHLAARRRDVDMARIL 117
G P++ A E + ++R LL+ T + + LH A+ +A +L
Sbjct: 599 GWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNVSERLVEEENICLHWASFTGSAAIAEVL 658
Query: 118 VDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHA 177
++ + A N G TPLHIAA E V F AN + + E T L E
Sbjct: 659 LNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDV 718
Query: 178 AIIELLADKFKASIFER 194
L K + + R
Sbjct: 719 WFALQLNRKLRLGVGNR 735
Score = 36.3 bits (80), Expect = 1.2
Identities = 60/274 (21%), Positives = 110/274 (40%), Gaps = 36/274 (13%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGM--TPVHVAAKFGNLATLVLLLEDGGDPL 791
L+++ + + K LMLL + PN ++ TP+H AA+ G++ +LL+ G +
Sbjct: 468 LYLSVKQGELQKVILMLLDN-LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 526
Query: 792 RKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASAL 851
K TPL A + ++ R++++ +G V + +EDG++ L
Sbjct: 527 AVDK-------QQRTPLMEAVVNNHLEVARYMVQ-----RGGCVYSK-----EEDGSTCL 569
Query: 852 HYACKV-TKEEVKIPTADRQVVKCLIENG--ADVSLQTRHNHETAFHYCAIAGNNDVMTE 908
H+A K+ E V + + QV ++G + H H G + +T+
Sbjct: 570 HHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTD 629
Query: 909 MIAHISTADVSRALNRQN-SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALH 967
++ R + +N + W A G + LL + + G + LH
Sbjct: 630 NVS-------ERLVEEENICLHW-----ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLH 677
Query: 968 LAAEHGYLQVCDALLTNKAFINSKARNGRTALHL 1001
+AA Y L+ A + + G TA L
Sbjct: 678 IAARESYHDCVLLFLSRGANPELRNKEGDTAWDL 711
>AB058779-1|BAB47505.2| 803|Homo sapiens KIAA1876 protein protein.
Length = 803
Score = 98.3 bits (234), Expect = 3e-19
Identities = 73/227 (32%), Positives = 111/227 (48%), Gaps = 21/227 (9%)
Query: 1131 NDSTPLQLAAEGGHADVVRVLVRAGA---SCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
N +PL AAE GH D+ +LV+AGA +C+++ R T + AAE+ H + +
Sbjct: 391 NKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQR---TPLMEAAENNHLEAVKYLIKA 447
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
L G T LH+AA G E V+ LLS+ V + + G TP
Sbjct: 448 GALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQ------------DDGGWTP 495
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
+ A + ++V+LLL S G + NE LH A F G + I +LL+ + LH
Sbjct: 496 MIWATEYKHVDLVKLLL-SKGSDINIRDNEENI-CLHWAAFSGCVDIAEILLAAKCD-LH 552
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
+ + HG + LHIA+ Y V + L + +++ +K G TPL CA+
Sbjct: 553 AVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 599
Score = 94.3 bits (224), Expect = 4e-18
Identities = 60/193 (31%), Positives = 104/193 (53%), Gaps = 7/193 (3%)
Query: 1029 KQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNL 1088
K++PLH AA +G +++C +L++ GANID E + P+ AA+NN+ E V+ +L + L
Sbjct: 392 KRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVK-YLIKAGAL 450
Query: 1089 VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDS--TPLQLAAEGGHAD 1146
V +G+TC H+AA +G +V++ L+ + V N +D TP+ A E H D
Sbjct: 451 VDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDV----NCQDDGGWTPMIWATEYKHVD 506
Query: 1147 VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
+V++L+ G+ + +H AA G ++ +++ + + G +PLHIAA
Sbjct: 507 LVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAA 566
Query: 1207 YYGQAETVRELLS 1219
+ + V LS
Sbjct: 567 RENRYDCVVLFLS 579
Score = 91.1 bits (216), Expect = 4e-17
Identities = 66/214 (30%), Positives = 110/214 (51%), Gaps = 10/214 (4%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
RS LH AAE G++ +C L+ A I++ + + RT L AA N + VK+LI+ A++
Sbjct: 393 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIK-AGALV 451
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
D + T LHLAA G EV + LL G +++ D+ G P+ A + + ++V+L
Sbjct: 452 DPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 511
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM--KFDRTGVISARNKLNDSTPLQLA 1139
L + ++ + ++ N C H AA G V + E L+ K D V ++ +PL +A
Sbjct: 512 LSKGSDINIRDNEE-NICLHWAAFSGCVDIAEILLAAKCDLHAV-----NIHGDSPLHIA 565
Query: 1140 AEGGHADVVRVLVRAGASCTDENRAGLTAVHLAA 1173
A D V + + + T +N+ G T + A+
Sbjct: 566 ARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 599
Score = 86.2 bits (204), Expect = 1e-15
Identities = 54/164 (32%), Positives = 83/164 (50%), Gaps = 4/164 (2%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
+PLH AA G+ ++ +L+ AG D S E+ PL A H+ V L+ A L
Sbjct: 394 SPLHAAAEAGHVDICHMLVQ-AGANIDTCS-EDQRTPLMEAAENNHLEAVKYLIKAGA-L 450
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGA-EINATDKNGWTPLHCAAKAGHLNVVKL 1364
+ D G T LH+A+ GHY++V+ LL G ++N D GWTP+ A + H+++VKL
Sbjct: 451 VDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKL 510
Query: 1365 LCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
L G+ N + +AA D+ E LL + D ++
Sbjct: 511 LLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAV 554
Score = 79.4 bits (187), Expect = 1e-13
Identities = 56/210 (26%), Positives = 102/210 (48%), Gaps = 4/210 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
+PL A GH+ + + L+ A +D + R+ L AAE+ +L+ L+ A ++
Sbjct: 394 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDP 453
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K G T LHLAA G+ +V++L+ + ++ TP+ A +++ KLLL
Sbjct: 454 KDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLS 513
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
G++I+ D +H AA + ++ ++ L +L A G++ HIAA +
Sbjct: 514 KGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDL-HAVNIHGDSPLHIAARENRYD 572
Query: 1111 VIEELMKFDRTGVISARNKLNDSTPLQLAA 1140
+ ++ R ++ +NK TPLQ A+
Sbjct: 573 CV--VLFLSRDSDVTLKNK-EGETPLQCAS 599
Score = 74.5 bits (175), Expect = 4e-12
Identities = 67/247 (27%), Positives = 113/247 (45%), Gaps = 6/247 (2%)
Query: 966 LHLAAEHGYLQVCDALLTNKAFINSKA--RNGRTALHLAAMNGYAHLVKFLIRDHNAMID 1023
L+ +A G LQ +L + N K +N R+ LH AA G+ + L++ A ID
Sbjct: 361 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQA-GANID 419
Query: 1024 VLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
+ ++TPL AA + +E K L++ GA +D D G +H AA+ + EVVQ +L
Sbjct: 420 TCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQ-YLL 478
Query: 1084 QHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGG 1143
+ + + DG I A + + +L+ + I+ R+ ++ L AA G
Sbjct: 479 SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL-LSKGSDINIRDN-EENICLHWAAFSG 536
Query: 1144 HADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLH 1203
D+ +L+ A N G + +H+AA + + + S ++ K G TPL
Sbjct: 537 CVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQ 596
Query: 1204 IAAYYGQ 1210
A+ Q
Sbjct: 597 CASLNSQ 603
Score = 74.1 bits (174), Expect = 5e-12
Identities = 77/276 (27%), Positives = 128/276 (46%), Gaps = 33/276 (11%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++ +A+ G L ++L+L DG DP K + +PL A + DI L++
Sbjct: 361 LYFSARQGELQKVLLMLVDGIDPNFKM-----EHQNKRSPLHAAAEAGHVDICHMLVQ-- 413
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A ID ED + L A + E VK LI+ GA V +
Sbjct: 414 --------AGANIDTCSEDQRTPLMEAAENNHLEA---------VKYLIKAGALVDPKDA 456
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
T H A G+ +V+ ++++ DV N Q+ GWTP++ A H+ LV
Sbjct: 457 EG-STCLHLAAKKGHYEVVQYLLSN-GQMDV----NCQDDGGWTPMIWATEYKHVDLVKL 510
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAM-NG 1006
LL+ + +++ D E LH AA G + + + LL K +++ +G + LH+AA N
Sbjct: 511 LLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENR 570
Query: 1007 YAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQI 1042
Y +V FL RD + + + + +TPL A+ + Q+
Sbjct: 571 YDCVVLFLSRDSD--VTLKNKEGETPLQCASLNSQV 604
Score = 69.7 bits (163), Expect = 1e-10
Identities = 50/164 (30%), Positives = 79/164 (48%), Gaps = 2/164 (1%)
Query: 1241 AESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLS 1300
+E TPL AA N + V+ L+ AG D E G LHLA GH +V LLS
Sbjct: 422 SEDQRTPLMEAAENNHLEAVKYLIK-AGALVDPKDAE-GSTCLHLAAKKGHYEVVQYLLS 479
Query: 1301 RSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
++ D G T + A+ + H +V++LL +G++IN D LH AA +G ++
Sbjct: 480 NGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVD 539
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
+ ++L + + +P+ AA EN D + L ++ D
Sbjct: 540 IAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSD 583
Score = 66.9 bits (156), Expect = 7e-10
Identities = 46/158 (29%), Positives = 74/158 (46%), Gaps = 2/158 (1%)
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
L+ +A G V L+L ++N +PLH A GH+ I +L+ A +
Sbjct: 361 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGAN-ID 419
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
+ +T L A+ + H + V+ L+ GA ++ D G T LH AAK GH VV+ L
Sbjct: 420 TCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLS 479
Query: 1368 SG-ASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
+G + + P+ +A H D+++ LL K D
Sbjct: 480 NGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSD 517
Score = 62.5 bits (145), Expect = 2e-08
Identities = 48/169 (28%), Positives = 77/169 (45%), Gaps = 4/169 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
Q + PL A EAG+ + L+ Q + + T L AA ++ + L+
Sbjct: 390 QNKRSPLHAAAEAGHVDICHMLV--QAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKA 447
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFY-GVRANAAIADNEDRTPMHLAAENGHAAI 179
GA+VD + G T LH+AA +G +V+Y + + D+ TPM A E H +
Sbjct: 448 GALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDL 507
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
++LL K + I R + + +H A+ +G D A +L LH N
Sbjct: 508 VKLLLSK-GSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVN 555
Score = 60.1 bits (139), Expect = 8e-08
Identities = 45/167 (26%), Positives = 75/167 (44%), Gaps = 4/167 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL+ A E + V+ L+ A K G T LHLAA++ ++ + L+ G +
Sbjct: 426 RTPLMEAAENNHLEAVKYLIKAGALVDPKDAE--GSTCLHLAAKKGHYEVVQYLLSNGQM 483
Query: 124 -VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+ + G TP+ A LVK ++ I DNE+ +H AA +G I E+
Sbjct: 484 DVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEI 543
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L K + G + +HIA+ DC ++ + + + NK
Sbjct: 544 LLAA-KCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNK 589
Score = 56.8 bits (131), Expect = 8e-07
Identities = 49/155 (31%), Positives = 75/155 (48%), Gaps = 12/155 (7%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDN--YTALHIAVESCKPAVVETLL 716
K +G+ +H AA+ GH ++ LL G+ +DV D+ +T + A E +V+ LL
Sbjct: 454 KDAEGSTCLHLAAKKGHYEVVQYLLSNGQ-MDVNCQDDGGWTPMIWATEYKHVDLVKLLL 512
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
G+D++IR ++ LH AA D A +LL + + G +P+H+AA+
Sbjct: 513 SKGSDINIRDNEENIC-LHWAAFSGCVD-IAEILLAAKCDLHAVNIHGDSPLHIAARENR 570
Query: 777 LATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMA 811
+VL L D K K GETPLQ A
Sbjct: 571 YDCVVLFLSRDSDVTLKNK-------EGETPLQCA 598
Score = 56.0 bits (129), Expect = 1e-06
Identities = 39/133 (29%), Positives = 63/133 (47%), Gaps = 1/133 (0%)
Query: 657 KYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLL 716
K +H + +H AA GHV I + L+Q G ++D + D T L A E+ V+ L+
Sbjct: 386 KMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI 445
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
GA V + + T LH+AA+ + +L N + G TP+ A ++ +
Sbjct: 446 KAGALVDPKDA-EGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKH 504
Query: 777 LATLVLLLEDGGD 789
+ + LLL G D
Sbjct: 505 VDLVKLLLSKGSD 517
Score = 56.0 bits (129), Expect = 1e-06
Identities = 37/142 (26%), Positives = 69/142 (48%), Gaps = 6/142 (4%)
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA--S 1371
++ LH A+ GH + +L+ GA I+ ++ TPL AA+ HL VK L ++GA
Sbjct: 393 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVD 452
Query: 1372 PKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIE 1431
PK C + AA + H +V++YLL + DD + M+ + + ++ +
Sbjct: 453 PKDAEGSTC--LHLAAKKGHYEVVQYLLSNGQMDVNCQDDGG--WTPMIWATEYKHVDLV 508
Query: 1432 EFVLVSPAPVDTAAKLSNIYIN 1453
+ +L + ++ NI ++
Sbjct: 509 KLLLSKGSDINIRDNEENICLH 530
Score = 52.4 bits (120), Expect = 2e-05
Identities = 32/103 (31%), Positives = 49/103 (47%), Gaps = 2/103 (1%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
A Y HV ++ LL KG +++ N+ LH A S + E LL D+H
Sbjct: 499 ATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLH-AVNIH 557
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAA 772
++PLHIAAR D C ++ L + ++G TP+ A+
Sbjct: 558 GDSPLHIAARENRYD-CVVLFLSRDSDVTLKNKEGETPLQCAS 599
Score = 50.4 bits (115), Expect = 7e-05
Identities = 31/112 (27%), Positives = 59/112 (52%), Gaps = 3/112 (2%)
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN--ATDKNGW 1347
G ++ L++ +E H K L+ ++ G Q V ++L G + N +N
Sbjct: 335 GKETLESALIALDSEKPKKLRFHPKQ-LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKR 393
Query: 1348 TPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+PLH AA+AGH+++ +L ++GA+ + + P+ AA NH + ++YL+
Sbjct: 394 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI 445
Score = 49.2 bits (112), Expect = 2e-04
Identities = 37/158 (23%), Positives = 72/158 (45%), Gaps = 4/158 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L LA + G+ +V+ LLS + + G T + A + VD+ ++L+ G+
Sbjct: 458 GSTCLHLAAKKGHYEVVQYLLSNGQMD-VNCQDDGGWTPMIWATEYKHVDLVKLLLSKGS 516
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
++ + LH AA G + + + + + +P+H+AA EN + ++
Sbjct: 517 DINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVL 576
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
L+ ++ + K+G T + ASLN A+ + K
Sbjct: 577 FLSRDSDVTL--KNKEGETPLQCASLNSQVWSALQMSK 612
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/89 (29%), Positives = 44/89 (49%), Gaps = 3/89 (3%)
Query: 135 LHIAAAEGD--EPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIF 192
L+ +A +G+ + L+ G+ N + R+P+H AAE GH I +L + A+I
Sbjct: 361 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLV-QAGANID 419
Query: 193 ERTKDGSTLMHIASLNGHADCAMMLFKKG 221
++D T + A+ N H + L K G
Sbjct: 420 TCSEDQRTPLMEAAENNHLEAVKYLIKAG 448
>AB028932-1|BAB56104.1| 917|Homo sapiens GLP1 protein.
Length = 917
Score = 98.3 bits (234), Expect = 3e-19
Identities = 73/227 (32%), Positives = 111/227 (48%), Gaps = 21/227 (9%)
Query: 1131 NDSTPLQLAAEGGHADVVRVLVRAGA---SCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
N +PL AAE GH D+ +LV+AGA +C+++ R T + AAE+ H + +
Sbjct: 391 NKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQR---TPLMEAAENNHLEAVKYLIKA 447
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTP 1247
L G T LH+AA G E V+ LLS+ V + + G TP
Sbjct: 448 GALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQ------------DDGGWTP 495
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
+ A + ++V+LLL S G + NE LH A F G + I +LL+ + LH
Sbjct: 496 MIWATEYKHVDLVKLLL-SKGSDINIRDNEENI-CLHWAAFSGCVDIAEILLAAKCD-LH 552
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAA 1354
+ + HG + LHIA+ Y V + L + +++ +K G TPL CA+
Sbjct: 553 AVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 599
Score = 94.3 bits (224), Expect = 4e-18
Identities = 60/193 (31%), Positives = 104/193 (53%), Gaps = 7/193 (3%)
Query: 1029 KQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNL 1088
K++PLH AA +G +++C +L++ GANID E + P+ AA+NN+ E V+ +L + L
Sbjct: 392 KRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVK-YLIKAGAL 450
Query: 1089 VMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDS--TPLQLAAEGGHAD 1146
V +G+TC H+AA +G +V++ L+ + V N +D TP+ A E H D
Sbjct: 451 VDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDV----NCQDDGGWTPMIWATEYKHVD 506
Query: 1147 VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
+V++L+ G+ + +H AA G ++ +++ + + G +PLHIAA
Sbjct: 507 LVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAA 566
Query: 1207 YYGQAETVRELLS 1219
+ + V LS
Sbjct: 567 RENRYDCVVLFLS 579
Score = 91.1 bits (216), Expect = 4e-17
Identities = 66/214 (30%), Positives = 110/214 (51%), Gaps = 10/214 (4%)
Query: 963 RSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMI 1022
RS LH AAE G++ +C L+ A I++ + + RT L AA N + VK+LI+ A++
Sbjct: 393 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIK-AGALV 451
Query: 1023 DVLTLKKQTPLHLAAASGQIEVCKLLLELG-ANIDATDELGQKPIHAAAQNNYSEVVQLF 1081
D + T LHLAA G EV + LL G +++ D+ G P+ A + + ++V+L
Sbjct: 452 DPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 511
Query: 1082 LQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM--KFDRTGVISARNKLNDSTPLQLA 1139
L + ++ + ++ N C H AA G V + E L+ K D V ++ +PL +A
Sbjct: 512 LSKGSDINIRDNEE-NICLHWAAFSGCVDIAEILLAAKCDLHAV-----NIHGDSPLHIA 565
Query: 1140 AEGGHADVVRVLVRAGASCTDENRAGLTAVHLAA 1173
A D V + + + T +N+ G T + A+
Sbjct: 566 ARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 599
Score = 86.2 bits (204), Expect = 1e-15
Identities = 54/164 (32%), Positives = 83/164 (50%), Gaps = 4/164 (2%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
+PLH AA G+ ++ +L+ AG D S E+ PL A H+ V L+ A L
Sbjct: 394 SPLHAAAEAGHVDICHMLVQ-AGANIDTCS-EDQRTPLMEAAENNHLEAVKYLIKAGA-L 450
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGA-EINATDKNGWTPLHCAAKAGHLNVVKL 1364
+ D G T LH+A+ GHY++V+ LL G ++N D GWTP+ A + H+++VKL
Sbjct: 451 VDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKL 510
Query: 1365 LCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSL 1408
L G+ N + +AA D+ E LL + D ++
Sbjct: 511 LLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAV 554
Score = 79.4 bits (187), Expect = 1e-13
Identities = 56/210 (26%), Positives = 102/210 (48%), Gaps = 4/210 (1%)
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
+PL A GH+ + + L+ A +D + R+ L AAE+ +L+ L+ A ++
Sbjct: 394 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDP 453
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K G T LHLAA G+ +V++L+ + ++ TP+ A +++ KLLL
Sbjct: 454 KDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLS 513
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVK 1110
G++I+ D +H AA + ++ ++ L +L A G++ HIAA +
Sbjct: 514 KGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDL-HAVNIHGDSPLHIAARENRYD 572
Query: 1111 VIEELMKFDRTGVISARNKLNDSTPLQLAA 1140
+ ++ R ++ +NK TPLQ A+
Sbjct: 573 CV--VLFLSRDSDVTLKNK-EGETPLQCAS 599
Score = 74.5 bits (175), Expect = 4e-12
Identities = 67/247 (27%), Positives = 113/247 (45%), Gaps = 6/247 (2%)
Query: 966 LHLAAEHGYLQVCDALLTNKAFINSKA--RNGRTALHLAAMNGYAHLVKFLIRDHNAMID 1023
L+ +A G LQ +L + N K +N R+ LH AA G+ + L++ A ID
Sbjct: 361 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQA-GANID 419
Query: 1024 VLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ 1083
+ ++TPL AA + +E K L++ GA +D D G +H AA+ + EVVQ +L
Sbjct: 420 TCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQ-YLL 478
Query: 1084 QHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGG 1143
+ + + DG I A + + +L+ + I+ R+ ++ L AA G
Sbjct: 479 SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL-LSKGSDINIRDN-EENICLHWAAFSG 536
Query: 1144 HADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLH 1203
D+ +L+ A N G + +H+AA + + + S ++ K G TPL
Sbjct: 537 CVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQ 596
Query: 1204 IAAYYGQ 1210
A+ Q
Sbjct: 597 CASLNSQ 603
Score = 74.1 bits (174), Expect = 5e-12
Identities = 77/276 (27%), Positives = 128/276 (46%), Gaps = 33/276 (11%)
Query: 768 VHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFV 827
++ +A+ G L ++L+L DG DP K + +PL A + DI L++
Sbjct: 361 LYFSARQGELQKVLLMLVDGIDPNFKM-----EHQNKRSPLHAAAEAGHVDICHMLVQ-- 413
Query: 828 KDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTR 887
+ A ID ED + L A + E VK LI+ GA V +
Sbjct: 414 --------AGANIDTCSEDQRTPLMEAAENNHLEA---------VKYLIKAGALVDPKDA 456
Query: 888 HNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNT 947
T H A G+ +V+ ++++ DV N Q+ GWTP++ A H+ LV
Sbjct: 457 EG-STCLHLAAKKGHYEVVQYLLSN-GQMDV----NCQDDGGWTPMIWATEYKHVDLVKL 510
Query: 948 LLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAM-NG 1006
LL+ + +++ D E LH AA G + + + LL K +++ +G + LH+AA N
Sbjct: 511 LLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENR 570
Query: 1007 YAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQI 1042
Y +V FL RD + + + + +TPL A+ + Q+
Sbjct: 571 YDCVVLFLSRDSD--VTLKNKEGETPLQCASLNSQV 604
Score = 69.7 bits (163), Expect = 1e-10
Identities = 50/164 (30%), Positives = 79/164 (48%), Gaps = 2/164 (1%)
Query: 1241 AESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLS 1300
+E TPL AA N + V+ L+ AG D E G LHLA GH +V LLS
Sbjct: 422 SEDQRTPLMEAAENNHLEAVKYLIK-AGALVDPKDAE-GSTCLHLAAKKGHYEVVQYLLS 479
Query: 1301 RSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
++ D G T + A+ + H +V++LL +G++IN D LH AA +G ++
Sbjct: 480 NGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVD 539
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
+ ++L + + +P+ AA EN D + L ++ D
Sbjct: 540 IAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSD 583
Score = 66.9 bits (156), Expect = 7e-10
Identities = 46/158 (29%), Positives = 74/158 (46%), Gaps = 2/158 (1%)
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
L+ +A G V L+L ++N +PLH A GH+ I +L+ A +
Sbjct: 361 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGAN-ID 419
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
+ +T L A+ + H + V+ L+ GA ++ D G T LH AAK GH VV+ L
Sbjct: 420 TCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLS 479
Query: 1368 SG-ASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
+G + + P+ +A H D+++ LL K D
Sbjct: 480 NGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSD 517
Score = 62.5 bits (145), Expect = 2e-08
Identities = 48/169 (28%), Positives = 77/169 (45%), Gaps = 4/169 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
Q + PL A EAG+ + L+ Q + + T L AA ++ + L+
Sbjct: 390 QNKRSPLHAAAEAGHVDICHMLV--QAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKA 447
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFY-GVRANAAIADNEDRTPMHLAAENGHAAI 179
GA+VD + G T LH+AA +G +V+Y + + D+ TPM A E H +
Sbjct: 448 GALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDL 507
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
++LL K + I R + + +H A+ +G D A +L LH N
Sbjct: 508 VKLLLSK-GSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVN 555
Score = 60.1 bits (139), Expect = 8e-08
Identities = 45/167 (26%), Positives = 75/167 (44%), Gaps = 4/167 (2%)
Query: 64 KVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAV 123
+ PL+ A E + V+ L+ A K G T LHLAA++ ++ + L+ G +
Sbjct: 426 RTPLMEAAENNHLEAVKYLIKAGALVDPKDAE--GSTCLHLAAKKGHYEVVQYLLSNGQM 483
Query: 124 -VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+ + G TP+ A LVK ++ I DNE+ +H AA +G I E+
Sbjct: 484 DVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEI 543
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
L K + G + +HIA+ DC ++ + + + NK
Sbjct: 544 LLAA-KCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNK 589
Score = 56.8 bits (131), Expect = 8e-07
Identities = 49/155 (31%), Positives = 75/155 (48%), Gaps = 12/155 (7%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDN--YTALHIAVESCKPAVVETLL 716
K +G+ +H AA+ GH ++ LL G+ +DV D+ +T + A E +V+ LL
Sbjct: 454 KDAEGSTCLHLAAKKGHYEVVQYLLSNGQ-MDVNCQDDGGWTPMIWATEYKHVDLVKLLL 512
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
G+D++IR ++ LH AA D A +LL + + G +P+H+AA+
Sbjct: 513 SKGSDINIRDNEENIC-LHWAAFSGCVD-IAEILLAAKCDLHAVNIHGDSPLHIAARENR 570
Query: 777 LATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMA 811
+VL L D K K GETPLQ A
Sbjct: 571 YDCVVLFLSRDSDVTLKNK-------EGETPLQCA 598
Score = 56.0 bits (129), Expect = 1e-06
Identities = 39/133 (29%), Positives = 63/133 (47%), Gaps = 1/133 (0%)
Query: 657 KYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLL 716
K +H + +H AA GHV I + L+Q G ++D + D T L A E+ V+ L+
Sbjct: 386 KMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI 445
Query: 717 GYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGN 776
GA V + + T LH+AA+ + +L N + G TP+ A ++ +
Sbjct: 446 KAGALVDPKDA-EGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKH 504
Query: 777 LATLVLLLEDGGD 789
+ + LLL G D
Sbjct: 505 VDLVKLLLSKGSD 517
Score = 56.0 bits (129), Expect = 1e-06
Identities = 37/142 (26%), Positives = 69/142 (48%), Gaps = 6/142 (4%)
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA--S 1371
++ LH A+ GH + +L+ GA I+ ++ TPL AA+ HL VK L ++GA
Sbjct: 393 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVD 452
Query: 1372 PKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIE 1431
PK C + AA + H +V++YLL + DD + M+ + + ++ +
Sbjct: 453 PKDAEGSTC--LHLAAKKGHYEVVQYLLSNGQMDVNCQDDGG--WTPMIWATEYKHVDLV 508
Query: 1432 EFVLVSPAPVDTAAKLSNIYIN 1453
+ +L + ++ NI ++
Sbjct: 509 KLLLSKGSDINIRDNEENICLH 530
Score = 52.4 bits (120), Expect = 2e-05
Identities = 32/103 (31%), Positives = 49/103 (47%), Gaps = 2/103 (1%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
A Y HV ++ LL KG +++ N+ LH A S + E LL D+H
Sbjct: 499 ATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLH-AVNIH 557
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAA 772
++PLHIAAR D C ++ L + ++G TP+ A+
Sbjct: 558 GDSPLHIAARENRYD-CVVLFLSRDSDVTLKNKEGETPLQCAS 599
Score = 50.4 bits (115), Expect = 7e-05
Identities = 31/112 (27%), Positives = 59/112 (52%), Gaps = 3/112 (2%)
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEIN--ATDKNGW 1347
G ++ L++ +E H K L+ ++ G Q V ++L G + N +N
Sbjct: 335 GKETLESALIALDSEKPKKLRFHPKQ-LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKR 393
Query: 1348 TPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
+PLH AA+AGH+++ +L ++GA+ + + P+ AA NH + ++YL+
Sbjct: 394 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI 445
Score = 49.2 bits (112), Expect = 2e-04
Identities = 37/158 (23%), Positives = 72/158 (45%), Gaps = 4/158 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L LA + G+ +V+ LLS + + G T + A + VD+ ++L+ G+
Sbjct: 458 GSTCLHLAAKKGHYEVVQYLLSNGQMD-VNCQDDGGWTPMIWATEYKHVDLVKLLLSKGS 516
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAA-ENGHAAIIE 181
++ + LH AA G + + + + + +P+H+AA EN + ++
Sbjct: 517 DINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVL 576
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
L+ ++ + K+G T + ASLN A+ + K
Sbjct: 577 FLSRDSDVTL--KNKEGETPLQCASLNSQVWSALQMSK 612
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/89 (29%), Positives = 44/89 (49%), Gaps = 3/89 (3%)
Query: 135 LHIAAAEGD--EPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIF 192
L+ +A +G+ + L+ G+ N + R+P+H AAE GH I +L + A+I
Sbjct: 361 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLV-QAGANID 419
Query: 193 ERTKDGSTLMHIASLNGHADCAMMLFKKG 221
++D T + A+ N H + L K G
Sbjct: 420 TCSEDQRTPLMEAAENNHLEAVKYLIKAG 448
>D86982-1|BAA13218.1| 1180|Homo sapiens KIAA0229 protein.
Length = 1180
Score = 97.9 bits (233), Expect = 3e-19
Identities = 72/222 (32%), Positives = 106/222 (47%), Gaps = 7/222 (3%)
Query: 955 VDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
V+ D G + LH AA +G+ V + LL N A N G LHLAA G A +V+ L
Sbjct: 119 VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 178
Query: 1015 IRD--HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN 1072
I + ++ +T LH AA G EV K+LLE + + + P+ AA
Sbjct: 179 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALY 238
Query: 1073 NYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLND 1132
EVV++ L HPNL+ TK +T H+AA G V++ L+ + + +
Sbjct: 239 GRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAARNGHKAVVQVLLDAG----MDSNYQTEM 293
Query: 1133 STPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ L AA G DVV++L+ AG ++ GLTA+ E
Sbjct: 294 GSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRE 335
Score = 96.3 bits (229), Expect = 1e-18
Identities = 66/198 (33%), Positives = 101/198 (51%), Gaps = 6/198 (3%)
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
+N +S G+TPL A GH +V LL N A +V D +G LHLAA G Q+ L
Sbjct: 119 VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 178
Query: 982 L---TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
+ + +N + + TALH AA G+ +VK L+ + + K +TPL LAA
Sbjct: 179 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPT-MRNNKFETPLDLAAL 237
Query: 1039 SGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNT 1098
G++EV K+LL N+ + + P+H AA+N + VVQ+ L + T + +
Sbjct: 238 YGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQT--EMGS 295
Query: 1099 CAHIAAIQGSVKVIEELM 1116
H AA+ G V++ L+
Sbjct: 296 ALHEAALFGKTDVVQILL 313
Score = 92.7 bits (220), Expect = 1e-17
Identities = 71/223 (31%), Positives = 108/223 (48%), Gaps = 20/223 (8%)
Query: 1157 SCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRE 1216
+C D G T +H AA +GH +V++V+ + L + G PLH+AA+ G A+ VR
Sbjct: 120 NCVDST--GYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRL 177
Query: 1217 LLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASN 1276
L+ P + T LH AA G+ VV++LL D
Sbjct: 178 LIHQGPSHTRVNEQN----------NDNETALHCAAQYGHTEVVKVLLEEL---TDPTMR 224
Query: 1277 ENGY-NPLHLACFGGHMSIVGLLLSRSAELLH-STDRHGKTGLHIASTHGHYQMVEVLLG 1334
N + PL LA G + +V +LL+ LL +T +H T LH+A+ +GH +V+VLL
Sbjct: 225 NNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKH--TPLHLAARNGHKAVVQVLLD 282
Query: 1335 QGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETN 1377
G + N + G + LH AA G +VV++L +G + N
Sbjct: 283 AGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDN 324
Score = 91.5 bits (217), Expect = 3e-17
Identities = 70/220 (31%), Positives = 103/220 (46%), Gaps = 20/220 (9%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM--RSTNTLR 1191
TPL AA GH DVV VL+R A + G +HLAA G ++ ++ + + R
Sbjct: 128 TPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTR 187
Query: 1192 ISSKKL-GLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHL 1250
++ + T LH AA YG E V+ LL + P + TPL L
Sbjct: 188 VNEQNNDNETALHCAAQYGHTEVVKVLLEELTD-------------PTMRNNKFETPLDL 234
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AA G VV++LLN+ N + PLHLA GH ++V +LL + + T+
Sbjct: 235 AALYGRLEVVKMLLNAHPNLLSC--NTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTE 292
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPL 1350
+ LH A+ G +V++LL G ++N D +G T L
Sbjct: 293 MG--SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 330
Score = 89.8 bits (213), Expect = 9e-17
Identities = 88/291 (30%), Positives = 135/291 (46%), Gaps = 32/291 (10%)
Query: 1113 EELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA 1172
+EL++ RTG + A KL L GG G + GL +
Sbjct: 51 QELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGGSG----GGGGGSGGGGGGLGS---- 102
Query: 1173 AEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
+ H +++L + R N + S G TPLH AA G + V LL +++A T
Sbjct: 103 SSHPLSSLLSMWRGPNVNCVDST--GYTPLHHAALNGHKDVVEVLL-------RNDALTN 153
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNP--LHLACFGG 1290
V+ G PLHLAA+ G+ +VRLL++ G + +N N LH A G
Sbjct: 154 VA------DSKGCYPLHLAAWKGDAQIVRLLIHQ-GPSHTRVNEQNNDNETALHCAAQYG 206
Query: 1291 HMSIVGLLLSRSAELLHSTDRHGK--TGLHIASTHGHYQMVEVLLGQGAEINATDKNGWT 1348
H +V +LL EL T R+ K T L +A+ +G ++V++LL + + + T
Sbjct: 207 HTEVVKVLLE---ELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHT 263
Query: 1349 PLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
PLH AA+ GH VV++L ++G +T + A + AA DV++ LL
Sbjct: 264 PLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSA-LHEAALFGKTDVVQILL 313
Score = 85.0 bits (201), Expect = 3e-15
Identities = 57/165 (34%), Positives = 86/165 (52%), Gaps = 4/165 (2%)
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR- 1301
+G TPLH AA NG+++VV +LL + + A S G PLHLA + G IV LL+ +
Sbjct: 125 TGYTPLHHAALNGHKDVVEVLLRNDALTNVADSK--GCYPLHLAAWKGDAQIVRLLIHQG 182
Query: 1302 -SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
S ++ + +T LH A+ +GH ++V+VLL + + + TPL AA G L
Sbjct: 183 PSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLE 242
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
VVK+L + + S P+ AA H V++ LL D+
Sbjct: 243 VVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDS 287
Score = 77.0 bits (181), Expect = 7e-13
Identities = 50/170 (29%), Positives = 85/170 (50%), Gaps = 3/170 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELL-SAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+G PL LA G+ +VR L+ + ++ +TALH AA+ ++ ++L++
Sbjct: 158 KGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEE 217
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
N +TPL +AA G +VK N + + TP+HLAA NGH A++
Sbjct: 218 LTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVV 277
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
++L D S ++ T+ GS L H A+L G D +L G +++ + +
Sbjct: 278 QVLLDAGMDSNYQ-TEMGSAL-HEAALFGKTDVVQILLAAGTDVNIKDNH 325
Score = 76.6 bits (180), Expect = 9e-13
Identities = 65/225 (28%), Positives = 105/225 (46%), Gaps = 16/225 (7%)
Query: 1052 GANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKV 1111
G N++ D G P+H AA N + +VV++ L+ +A +K G H+AA +G ++
Sbjct: 116 GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSK-GCYPLHLAAWKGDAQI 174
Query: 1112 IEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHL 1171
+ L+ + ++ T L AA+ GH +VV+VL+ T N T + L
Sbjct: 175 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 234
Query: 1172 AAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT 1231
AA +G V+ ++ + + +S TPLH+AA G V+ LL + S T
Sbjct: 235 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLD---AGMDSNYQT 291
Query: 1232 GVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASN 1276
E G + LH AA G +VV++LL +AG + N
Sbjct: 292 ----------EMG-SALHEAALFGKTDVVQILL-AAGTDVNIKDN 324
Score = 60.1 bits (139), Expect = 8e-08
Identities = 40/112 (35%), Positives = 54/112 (48%), Gaps = 5/112 (4%)
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D G T LH A+ +GH +VEVLL A N D G PLH AA G +V+LL
Sbjct: 119 VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 178
Query: 1366 CESGAS---PKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRF 1414
G S + N N + AA H +V++ LL E T M + +F
Sbjct: 179 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLL--EELTDPTMRNNKF 228
Score = 59.7 bits (138), Expect = 1e-07
Identities = 42/129 (32%), Positives = 67/129 (51%), Gaps = 5/129 (3%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
D ++H AA+YGH ++ LL++ + N T L +A + VV+ LL +
Sbjct: 194 DNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPN 253
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCAL-MLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
+ + ++ TPLH+AAR +G K + +LL +G N TE G + +H AA FG +
Sbjct: 254 L-LSCNTKKHTPLHLAAR--NGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKTDVV 309
Query: 781 VLLLEDGGD 789
+LL G D
Sbjct: 310 QILLAAGTD 318
Score = 59.3 bits (137), Expect = 1e-07
Identities = 38/127 (29%), Positives = 60/127 (47%), Gaps = 2/127 (1%)
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G V+ + G TPLH AA G + +V+ A +AD++ P+HLAA G A I+
Sbjct: 116 GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 175
Query: 181 ELLADK--FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDE 238
LL + + E+ D T +H A+ GH + +L ++ M N FE
Sbjct: 176 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 235
Query: 239 VLFVKIE 245
L+ ++E
Sbjct: 236 ALYGRLE 242
Score = 56.4 bits (130), Expect = 1e-06
Identities = 40/141 (28%), Positives = 63/141 (44%), Gaps = 8/141 (5%)
Query: 82 LLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAE 141
LLS + G T LH AA D+ +L+ A+ + + G PLH+AA +
Sbjct: 110 LLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWK 169
Query: 142 GDEPLVKYFY-----GVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTK 196
GD +V+ R N DNE T +H AA+ GH ++++L ++ K
Sbjct: 170 GDAQIVRLLIHQGPSHTRVNEQNNDNE--TALHCAAQYGHTEVVKVLLEELTDPTMRNNK 227
Query: 197 DGSTLMHIASLNGHADCAMML 217
T + +A+L G + ML
Sbjct: 228 -FETPLDLAALYGRLEVVKML 247
Score = 54.4 bits (125), Expect = 4e-06
Identities = 78/255 (30%), Positives = 109/255 (42%), Gaps = 39/255 (15%)
Query: 750 LLKSGAGPNKATED--GMTPVHVAAKFGNLATL-VLLLEDGGDPLRKTKVCIYDVVTGET 806
LL GPN D G TP+H AA G+ + VLL D + +K C
Sbjct: 110 LLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCY-------- 161
Query: 807 PLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPT 866
PL +A IVR LI H+G S + ++ + D +ALH A + EV
Sbjct: 162 PLHLAAWKGDAQIVRLLI-----HQGPSHTR--VNEQNNDNETALHCAAQYGHTEV---- 210
Query: 867 ADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMI-AHISTADVSRALNRQ 925
VK L+E D +++ + ET A+ G +V+ ++ AH +
Sbjct: 211 -----VKVLLEELTDPTMRN-NKFETPLDLAALYGRLEVVKMLLNAHPNLLSC------- 257
Query: 926 NSIGWTPLLIACHRGHMQLVNTLLTNHARVDV-FDVEGRSALHLAAEHGYLQVCDALLTN 984
N+ TPL +A GH +V LL A +D + E SALH AA G V LL
Sbjct: 258 NTKKHTPLHLAARNGHKAVVQVLLD--AGMDSNYQTEMGSALHEAALFGKTDVVQILLAA 315
Query: 985 KAFINSKARNGRTAL 999
+N K +G TAL
Sbjct: 316 GTDVNIKDNHGLTAL 330
Score = 50.4 bits (115), Expect = 7e-05
Identities = 61/230 (26%), Positives = 101/230 (43%), Gaps = 33/230 (14%)
Query: 685 KGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGD 744
+G +V+ + YT LH A + VVE LL A ++ K PLH+AA D
Sbjct: 115 RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCY-PLHLAAWKGDAQ 173
Query: 745 KCALMLLK--SGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDP-LRKTKVCIYDV 801
L++ + S N+ D T +H AA++G+ + +LLE+ DP +R K
Sbjct: 174 IVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKF----- 228
Query: 802 VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEE 861
ETPL +A ++V+ L+ H + + + + LH A +
Sbjct: 229 ---ETPLDLAALYGRLEVVKMLL---NAHPN-------LLSCNTKKHTPLHLAAR----- 270
Query: 862 VKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIA 911
+ VV+ L++ G D + QT +A H A+ G DV+ ++A
Sbjct: 271 ----NGHKAVVQVLLDAGMDSNYQTEMG--SALHEAALFGKTDVVQILLA 314
Score = 48.8 bits (111), Expect = 2e-04
Identities = 22/67 (32%), Positives = 36/67 (53%)
Query: 1335 QGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDV 1394
+G +N D G+TPLH AA GH +VV++L + A + C P+ AA + +
Sbjct: 115 RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 174
Query: 1395 LEYLLHK 1401
+ L+H+
Sbjct: 175 VRLLIHQ 181
Score = 45.6 bits (103), Expect = 0.002
Identities = 59/230 (25%), Positives = 94/230 (40%), Gaps = 34/230 (14%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA GH ++ LL+ +V + LH+A +V L+ G
Sbjct: 126 GYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPS- 184
Query: 723 HIRGGKQ---RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
H R +Q ET LH AA+ + +LL+ P TP+ +AA +G L
Sbjct: 185 HTRVNEQNNDNETALHCAAQY-GHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEV 243
Query: 780 LVLLLEDGGDPLR-KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ +LL + L TK TPL +A R+ +V+ L++ D ++
Sbjct: 244 VKMLLNAHPNLLSCNTK--------KHTPLHLAARNGHKAVVQVLLDAGMDSNYQT---- 291
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRH 888
+ SALH A K + VV+ L+ G DV+++ H
Sbjct: 292 -------EMGSALHEAALFGKTD---------VVQILLAAGTDVNIKDNH 325
Score = 39.5 bits (88), Expect = 0.13
Identities = 34/128 (26%), Positives = 56/128 (43%), Gaps = 5/128 (3%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA YG + ++ LL ++ +T LH+A + AVV+ LL G D + + +
Sbjct: 235 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQ--TE 292
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT--LVLLLEDG 787
+ LH AA D +LL +G N G+T + + + + + L+ED
Sbjct: 293 MGSALHEAALFGKTD-VVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDH 351
Query: 788 GDPLRKTK 795
R TK
Sbjct: 352 MTGKRSTK 359
>BC132832-1|AAI32833.1| 1134|Homo sapiens ankyrin repeat and sterile
alpha motif domain containing 1A protein.
Length = 1134
Score = 97.9 bits (233), Expect = 3e-19
Identities = 72/222 (32%), Positives = 106/222 (47%), Gaps = 7/222 (3%)
Query: 955 VDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
V+ D G + LH AA +G+ V + LL N A N G LHLAA G A +V+ L
Sbjct: 73 VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 132
Query: 1015 IRD--HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN 1072
I + ++ +T LH AA G EV K+LLE + + + P+ AA
Sbjct: 133 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALY 192
Query: 1073 NYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLND 1132
EVV++ L HPNL+ TK +T H+AA G V++ L+ + + +
Sbjct: 193 GRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAARNGHKAVVQVLLDAG----MDSNYQTEM 247
Query: 1133 STPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ L AA G DVV++L+ AG ++ GLTA+ E
Sbjct: 248 GSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRE 289
Score = 96.3 bits (229), Expect = 1e-18
Identities = 66/198 (33%), Positives = 101/198 (51%), Gaps = 6/198 (3%)
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
+N +S G+TPL A GH +V LL N A +V D +G LHLAA G Q+ L
Sbjct: 73 VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 132
Query: 982 L---TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
+ + +N + + TALH AA G+ +VK L+ + + K +TPL LAA
Sbjct: 133 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPT-MRNNKFETPLDLAAL 191
Query: 1039 SGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNT 1098
G++EV K+LL N+ + + P+H AA+N + VVQ+ L + T + +
Sbjct: 192 YGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQT--EMGS 249
Query: 1099 CAHIAAIQGSVKVIEELM 1116
H AA+ G V++ L+
Sbjct: 250 ALHEAALFGKTDVVQILL 267
Score = 92.7 bits (220), Expect = 1e-17
Identities = 71/223 (31%), Positives = 108/223 (48%), Gaps = 20/223 (8%)
Query: 1157 SCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRE 1216
+C D G T +H AA +GH +V++V+ + L + G PLH+AA+ G A+ VR
Sbjct: 74 NCVDST--GYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRL 131
Query: 1217 LLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASN 1276
L+ P + T LH AA G+ VV++LL D
Sbjct: 132 LIHQGPSHTRVNEQN----------NDNETALHCAAQYGHTEVVKVLLEEL---TDPTMR 178
Query: 1277 ENGY-NPLHLACFGGHMSIVGLLLSRSAELLH-STDRHGKTGLHIASTHGHYQMVEVLLG 1334
N + PL LA G + +V +LL+ LL +T +H T LH+A+ +GH +V+VLL
Sbjct: 179 NNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKH--TPLHLAARNGHKAVVQVLLD 236
Query: 1335 QGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETN 1377
G + N + G + LH AA G +VV++L +G + N
Sbjct: 237 AGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDN 278
Score = 91.5 bits (217), Expect = 3e-17
Identities = 70/220 (31%), Positives = 103/220 (46%), Gaps = 20/220 (9%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM--RSTNTLR 1191
TPL AA GH DVV VL+R A + G +HLAA G ++ ++ + + R
Sbjct: 82 TPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTR 141
Query: 1192 ISSKKL-GLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHL 1250
++ + T LH AA YG E V+ LL + P + TPL L
Sbjct: 142 VNEQNNDNETALHCAAQYGHTEVVKVLLEELTD-------------PTMRNNKFETPLDL 188
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AA G VV++LLN+ N + PLHLA GH ++V +LL + + T+
Sbjct: 189 AALYGRLEVVKMLLNAHPNLLSC--NTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTE 246
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPL 1350
+ LH A+ G +V++LL G ++N D +G T L
Sbjct: 247 MG--SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
Score = 89.8 bits (213), Expect = 9e-17
Identities = 88/291 (30%), Positives = 135/291 (46%), Gaps = 32/291 (10%)
Query: 1113 EELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA 1172
+EL++ RTG + A KL L GG G + GL +
Sbjct: 5 QELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGGSG----GGGGGSGGGGGGLGS---- 56
Query: 1173 AEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
+ H +++L + R N + S G TPLH AA G + V LL +++A T
Sbjct: 57 SSHPLSSLLSMWRGPNVNCVDST--GYTPLHHAALNGHKDVVEVLL-------RNDALTN 107
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNP--LHLACFGG 1290
V+ G PLHLAA+ G+ +VRLL++ G + +N N LH A G
Sbjct: 108 VA------DSKGCYPLHLAAWKGDAQIVRLLIHQ-GPSHTRVNEQNNDNETALHCAAQYG 160
Query: 1291 HMSIVGLLLSRSAELLHSTDRHGK--TGLHIASTHGHYQMVEVLLGQGAEINATDKNGWT 1348
H +V +LL EL T R+ K T L +A+ +G ++V++LL + + + T
Sbjct: 161 HTEVVKVLLE---ELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHT 217
Query: 1349 PLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
PLH AA+ GH VV++L ++G +T + A + AA DV++ LL
Sbjct: 218 PLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSA-LHEAALFGKTDVVQILL 267
Score = 85.0 bits (201), Expect = 3e-15
Identities = 57/165 (34%), Positives = 86/165 (52%), Gaps = 4/165 (2%)
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR- 1301
+G TPLH AA NG+++VV +LL + + A S G PLHLA + G IV LL+ +
Sbjct: 79 TGYTPLHHAALNGHKDVVEVLLRNDALTNVADSK--GCYPLHLAAWKGDAQIVRLLIHQG 136
Query: 1302 -SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
S ++ + +T LH A+ +GH ++V+VLL + + + TPL AA G L
Sbjct: 137 PSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLE 196
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
VVK+L + + S P+ AA H V++ LL D+
Sbjct: 197 VVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDS 241
Score = 77.0 bits (181), Expect = 7e-13
Identities = 50/170 (29%), Positives = 85/170 (50%), Gaps = 3/170 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELL-SAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+G PL LA G+ +VR L+ + ++ +TALH AA+ ++ ++L++
Sbjct: 112 KGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEE 171
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
N +TPL +AA G +VK N + + TP+HLAA NGH A++
Sbjct: 172 LTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVV 231
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
++L D S ++ T+ GS L H A+L G D +L G +++ + +
Sbjct: 232 QVLLDAGMDSNYQ-TEMGSAL-HEAALFGKTDVVQILLAAGTDVNIKDNH 279
Score = 76.6 bits (180), Expect = 9e-13
Identities = 65/225 (28%), Positives = 105/225 (46%), Gaps = 16/225 (7%)
Query: 1052 GANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKV 1111
G N++ D G P+H AA N + +VV++ L+ +A +K G H+AA +G ++
Sbjct: 70 GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSK-GCYPLHLAAWKGDAQI 128
Query: 1112 IEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHL 1171
+ L+ + ++ T L AA+ GH +VV+VL+ T N T + L
Sbjct: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
Query: 1172 AAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT 1231
AA +G V+ ++ + + +S TPLH+AA G V+ LL + S T
Sbjct: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLD---AGMDSNYQT 245
Query: 1232 GVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASN 1276
E G + LH AA G +VV++LL +AG + N
Sbjct: 246 ----------EMG-SALHEAALFGKTDVVQILL-AAGTDVNIKDN 278
Score = 60.1 bits (139), Expect = 8e-08
Identities = 40/112 (35%), Positives = 54/112 (48%), Gaps = 5/112 (4%)
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D G T LH A+ +GH +VEVLL A N D G PLH AA G +V+LL
Sbjct: 73 VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 132
Query: 1366 CESGAS---PKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRF 1414
G S + N N + AA H +V++ LL E T M + +F
Sbjct: 133 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLL--EELTDPTMRNNKF 182
Score = 59.7 bits (138), Expect = 1e-07
Identities = 42/129 (32%), Positives = 67/129 (51%), Gaps = 5/129 (3%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
D ++H AA+YGH ++ LL++ + N T L +A + VV+ LL +
Sbjct: 148 DNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPN 207
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCAL-MLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
+ + ++ TPLH+AAR +G K + +LL +G N TE G + +H AA FG +
Sbjct: 208 L-LSCNTKKHTPLHLAAR--NGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKTDVV 263
Query: 781 VLLLEDGGD 789
+LL G D
Sbjct: 264 QILLAAGTD 272
Score = 59.3 bits (137), Expect = 1e-07
Identities = 38/127 (29%), Positives = 60/127 (47%), Gaps = 2/127 (1%)
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G V+ + G TPLH AA G + +V+ A +AD++ P+HLAA G A I+
Sbjct: 70 GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
Query: 181 ELLADK--FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDE 238
LL + + E+ D T +H A+ GH + +L ++ M N FE
Sbjct: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
Query: 239 VLFVKIE 245
L+ ++E
Sbjct: 190 ALYGRLE 196
Score = 56.4 bits (130), Expect = 1e-06
Identities = 40/141 (28%), Positives = 63/141 (44%), Gaps = 8/141 (5%)
Query: 82 LLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAE 141
LLS + G T LH AA D+ +L+ A+ + + G PLH+AA +
Sbjct: 64 LLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWK 123
Query: 142 GDEPLVKYFY-----GVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTK 196
GD +V+ R N DNE T +H AA+ GH ++++L ++ K
Sbjct: 124 GDAQIVRLLIHQGPSHTRVNEQNNDNE--TALHCAAQYGHTEVVKVLLEELTDPTMRNNK 181
Query: 197 DGSTLMHIASLNGHADCAMML 217
T + +A+L G + ML
Sbjct: 182 -FETPLDLAALYGRLEVVKML 201
Score = 54.4 bits (125), Expect = 4e-06
Identities = 78/255 (30%), Positives = 109/255 (42%), Gaps = 39/255 (15%)
Query: 750 LLKSGAGPNKATED--GMTPVHVAAKFGNLATL-VLLLEDGGDPLRKTKVCIYDVVTGET 806
LL GPN D G TP+H AA G+ + VLL D + +K C
Sbjct: 64 LLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCY-------- 115
Query: 807 PLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPT 866
PL +A IVR LI H+G S + ++ + D +ALH A + EV
Sbjct: 116 PLHLAAWKGDAQIVRLLI-----HQGPSHTR--VNEQNNDNETALHCAAQYGHTEV---- 164
Query: 867 ADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMI-AHISTADVSRALNRQ 925
VK L+E D +++ + ET A+ G +V+ ++ AH +
Sbjct: 165 -----VKVLLEELTDPTMRN-NKFETPLDLAALYGRLEVVKMLLNAHPNLLSC------- 211
Query: 926 NSIGWTPLLIACHRGHMQLVNTLLTNHARVDV-FDVEGRSALHLAAEHGYLQVCDALLTN 984
N+ TPL +A GH +V LL A +D + E SALH AA G V LL
Sbjct: 212 NTKKHTPLHLAARNGHKAVVQVLLD--AGMDSNYQTEMGSALHEAALFGKTDVVQILLAA 269
Query: 985 KAFINSKARNGRTAL 999
+N K +G TAL
Sbjct: 270 GTDVNIKDNHGLTAL 284
Score = 50.4 bits (115), Expect = 7e-05
Identities = 61/230 (26%), Positives = 101/230 (43%), Gaps = 33/230 (14%)
Query: 685 KGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGD 744
+G +V+ + YT LH A + VVE LL A ++ K PLH+AA D
Sbjct: 69 RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCY-PLHLAAWKGDAQ 127
Query: 745 KCALMLLK--SGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDP-LRKTKVCIYDV 801
L++ + S N+ D T +H AA++G+ + +LLE+ DP +R K
Sbjct: 128 IVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKF----- 182
Query: 802 VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEE 861
ETPL +A ++V+ L+ H + + + + LH A +
Sbjct: 183 ---ETPLDLAALYGRLEVVKMLL---NAHPN-------LLSCNTKKHTPLHLAAR----- 224
Query: 862 VKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIA 911
+ VV+ L++ G D + QT +A H A+ G DV+ ++A
Sbjct: 225 ----NGHKAVVQVLLDAGMDSNYQTEMG--SALHEAALFGKTDVVQILLA 268
Score = 48.8 bits (111), Expect = 2e-04
Identities = 22/67 (32%), Positives = 36/67 (53%)
Query: 1335 QGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDV 1394
+G +N D G+TPLH AA GH +VV++L + A + C P+ AA + +
Sbjct: 69 RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
Query: 1395 LEYLLHK 1401
+ L+H+
Sbjct: 129 VRLLIHQ 135
Score = 45.6 bits (103), Expect = 0.002
Identities = 59/230 (25%), Positives = 94/230 (40%), Gaps = 34/230 (14%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA GH ++ LL+ +V + LH+A +V L+ G
Sbjct: 80 GYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPS- 138
Query: 723 HIRGGKQ---RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
H R +Q ET LH AA+ + +LL+ P TP+ +AA +G L
Sbjct: 139 HTRVNEQNNDNETALHCAAQY-GHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEV 197
Query: 780 LVLLLEDGGDPLR-KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ +LL + L TK TPL +A R+ +V+ L++ D ++
Sbjct: 198 VKMLLNAHPNLLSCNTK--------KHTPLHLAARNGHKAVVQVLLDAGMDSNYQT---- 245
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRH 888
+ SALH A K + VV+ L+ G DV+++ H
Sbjct: 246 -------EMGSALHEAALFGKTD---------VVQILLAAGTDVNIKDNH 279
Score = 39.5 bits (88), Expect = 0.13
Identities = 34/128 (26%), Positives = 56/128 (43%), Gaps = 5/128 (3%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA YG + ++ LL ++ +T LH+A + AVV+ LL G D + + +
Sbjct: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQ--TE 246
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT--LVLLLEDG 787
+ LH AA D +LL +G N G+T + + + + + L+ED
Sbjct: 247 MGSALHEAALFGKTD-VVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDH 305
Query: 788 GDPLRKTK 795
R TK
Sbjct: 306 MTGKRSTK 313
>BC022396-1|AAH22396.1| 472|Homo sapiens Unknown (protein for
IMAGE:4618556) protein.
Length = 472
Score = 97.9 bits (233), Expect = 3e-19
Identities = 72/222 (32%), Positives = 106/222 (47%), Gaps = 7/222 (3%)
Query: 955 VDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
V+ D G + LH AA +G+ V + LL N A N G LHLAA G A +V+ L
Sbjct: 73 VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 132
Query: 1015 IRD--HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN 1072
I + ++ +T LH AA G EV K+LLE + + + P+ AA
Sbjct: 133 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALY 192
Query: 1073 NYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLND 1132
EVV++ L HPNL+ TK +T H+AA G V++ L+ + + +
Sbjct: 193 GRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAARNGHKAVVQVLLDAG----MDSNYQTEM 247
Query: 1133 STPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ L AA G DVV++L+ AG ++ GLTA+ E
Sbjct: 248 GSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRE 289
Score = 96.3 bits (229), Expect = 1e-18
Identities = 66/198 (33%), Positives = 101/198 (51%), Gaps = 6/198 (3%)
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
+N +S G+TPL A GH +V LL N A +V D +G LHLAA G Q+ L
Sbjct: 73 VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 132
Query: 982 L---TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
+ + +N + + TALH AA G+ +VK L+ + + K +TPL LAA
Sbjct: 133 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPT-MRNNKFETPLDLAAL 191
Query: 1039 SGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNT 1098
G++EV K+LL N+ + + P+H AA+N + VVQ+ L + T + +
Sbjct: 192 YGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQT--EMGS 249
Query: 1099 CAHIAAIQGSVKVIEELM 1116
H AA+ G V++ L+
Sbjct: 250 ALHEAALFGKTDVVQILL 267
Score = 92.7 bits (220), Expect = 1e-17
Identities = 71/223 (31%), Positives = 108/223 (48%), Gaps = 20/223 (8%)
Query: 1157 SCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRE 1216
+C D G T +H AA +GH +V++V+ + L + G PLH+AA+ G A+ VR
Sbjct: 74 NCVDST--GYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRL 131
Query: 1217 LLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASN 1276
L+ P + T LH AA G+ VV++LL D
Sbjct: 132 LIHQGPSHTRVNEQN----------NDNETALHCAAQYGHTEVVKVLLEEL---TDPTMR 178
Query: 1277 ENGY-NPLHLACFGGHMSIVGLLLSRSAELLH-STDRHGKTGLHIASTHGHYQMVEVLLG 1334
N + PL LA G + +V +LL+ LL +T +H T LH+A+ +GH +V+VLL
Sbjct: 179 NNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKH--TPLHLAARNGHKAVVQVLLD 236
Query: 1335 QGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETN 1377
G + N + G + LH AA G +VV++L +G + N
Sbjct: 237 AGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDN 278
Score = 91.5 bits (217), Expect = 3e-17
Identities = 70/220 (31%), Positives = 103/220 (46%), Gaps = 20/220 (9%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM--RSTNTLR 1191
TPL AA GH DVV VL+R A + G +HLAA G ++ ++ + + R
Sbjct: 82 TPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTR 141
Query: 1192 ISSKKL-GLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHL 1250
++ + T LH AA YG E V+ LL + P + TPL L
Sbjct: 142 VNEQNNDNETALHCAAQYGHTEVVKVLLEELTD-------------PTMRNNKFETPLDL 188
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AA G VV++LLN+ N + PLHLA GH ++V +LL + + T+
Sbjct: 189 AALYGRLEVVKMLLNAHPNLLSC--NTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTE 246
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPL 1350
+ LH A+ G +V++LL G ++N D +G T L
Sbjct: 247 MG--SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
Score = 89.8 bits (213), Expect = 9e-17
Identities = 88/291 (30%), Positives = 135/291 (46%), Gaps = 32/291 (10%)
Query: 1113 EELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA 1172
+EL++ RTG + A KL L GG G + GL +
Sbjct: 5 QELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGGSG----GGGGGSGGGGGGLGS---- 56
Query: 1173 AEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
+ H +++L + R N + S G TPLH AA G + V LL +++A T
Sbjct: 57 SSHPLSSLLSMWRGPNVNCVDST--GYTPLHHAALNGHKDVVEVLL-------RNDALTN 107
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNP--LHLACFGG 1290
V+ G PLHLAA+ G+ +VRLL++ G + +N N LH A G
Sbjct: 108 VA------DSKGCYPLHLAAWKGDAQIVRLLIHQ-GPSHTRVNEQNNDNETALHCAAQYG 160
Query: 1291 HMSIVGLLLSRSAELLHSTDRHGK--TGLHIASTHGHYQMVEVLLGQGAEINATDKNGWT 1348
H +V +LL EL T R+ K T L +A+ +G ++V++LL + + + T
Sbjct: 161 HTEVVKVLLE---ELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHT 217
Query: 1349 PLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
PLH AA+ GH VV++L ++G +T + A + AA DV++ LL
Sbjct: 218 PLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSA-LHEAALFGKTDVVQILL 267
Score = 85.0 bits (201), Expect = 3e-15
Identities = 57/165 (34%), Positives = 86/165 (52%), Gaps = 4/165 (2%)
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR- 1301
+G TPLH AA NG+++VV +LL + + A S G PLHLA + G IV LL+ +
Sbjct: 79 TGYTPLHHAALNGHKDVVEVLLRNDALTNVADSK--GCYPLHLAAWKGDAQIVRLLIHQG 136
Query: 1302 -SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
S ++ + +T LH A+ +GH ++V+VLL + + + TPL AA G L
Sbjct: 137 PSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLE 196
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
VVK+L + + S P+ AA H V++ LL D+
Sbjct: 197 VVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDS 241
Score = 77.0 bits (181), Expect = 7e-13
Identities = 50/170 (29%), Positives = 85/170 (50%), Gaps = 3/170 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELL-SAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+G PL LA G+ +VR L+ + ++ +TALH AA+ ++ ++L++
Sbjct: 112 KGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEE 171
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
N +TPL +AA G +VK N + + TP+HLAA NGH A++
Sbjct: 172 LTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVV 231
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
++L D S ++ T+ GS L H A+L G D +L G +++ + +
Sbjct: 232 QVLLDAGMDSNYQ-TEMGSAL-HEAALFGKTDVVQILLAAGTDVNIKDNH 279
Score = 76.6 bits (180), Expect = 9e-13
Identities = 65/225 (28%), Positives = 105/225 (46%), Gaps = 16/225 (7%)
Query: 1052 GANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKV 1111
G N++ D G P+H AA N + +VV++ L+ +A +K G H+AA +G ++
Sbjct: 70 GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSK-GCYPLHLAAWKGDAQI 128
Query: 1112 IEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHL 1171
+ L+ + ++ T L AA+ GH +VV+VL+ T N T + L
Sbjct: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
Query: 1172 AAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT 1231
AA +G V+ ++ + + +S TPLH+AA G V+ LL + S T
Sbjct: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLD---AGMDSNYQT 245
Query: 1232 GVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASN 1276
E G + LH AA G +VV++LL +AG + N
Sbjct: 246 ----------EMG-SALHEAALFGKTDVVQILL-AAGTDVNIKDN 278
Score = 60.1 bits (139), Expect = 8e-08
Identities = 40/112 (35%), Positives = 54/112 (48%), Gaps = 5/112 (4%)
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D G T LH A+ +GH +VEVLL A N D G PLH AA G +V+LL
Sbjct: 73 VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 132
Query: 1366 CESGAS---PKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRF 1414
G S + N N + AA H +V++ LL E T M + +F
Sbjct: 133 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLL--EELTDPTMRNNKF 182
Score = 59.7 bits (138), Expect = 1e-07
Identities = 42/129 (32%), Positives = 67/129 (51%), Gaps = 5/129 (3%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
D ++H AA+YGH ++ LL++ + N T L +A + VV+ LL +
Sbjct: 148 DNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPN 207
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCAL-MLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
+ + ++ TPLH+AAR +G K + +LL +G N TE G + +H AA FG +
Sbjct: 208 L-LSCNTKKHTPLHLAAR--NGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKTDVV 263
Query: 781 VLLLEDGGD 789
+LL G D
Sbjct: 264 QILLAAGTD 272
Score = 59.3 bits (137), Expect = 1e-07
Identities = 38/127 (29%), Positives = 60/127 (47%), Gaps = 2/127 (1%)
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G V+ + G TPLH AA G + +V+ A +AD++ P+HLAA G A I+
Sbjct: 70 GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
Query: 181 ELLADK--FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDE 238
LL + + E+ D T +H A+ GH + +L ++ M N FE
Sbjct: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
Query: 239 VLFVKIE 245
L+ ++E
Sbjct: 190 ALYGRLE 196
Score = 56.4 bits (130), Expect = 1e-06
Identities = 40/141 (28%), Positives = 63/141 (44%), Gaps = 8/141 (5%)
Query: 82 LLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAE 141
LLS + G T LH AA D+ +L+ A+ + + G PLH+AA +
Sbjct: 64 LLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWK 123
Query: 142 GDEPLVKYFY-----GVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTK 196
GD +V+ R N DNE T +H AA+ GH ++++L ++ K
Sbjct: 124 GDAQIVRLLIHQGPSHTRVNEQNNDNE--TALHCAAQYGHTEVVKVLLEELTDPTMRNNK 181
Query: 197 DGSTLMHIASLNGHADCAMML 217
T + +A+L G + ML
Sbjct: 182 -FETPLDLAALYGRLEVVKML 201
Score = 54.4 bits (125), Expect = 4e-06
Identities = 78/255 (30%), Positives = 109/255 (42%), Gaps = 39/255 (15%)
Query: 750 LLKSGAGPNKATED--GMTPVHVAAKFGNLATL-VLLLEDGGDPLRKTKVCIYDVVTGET 806
LL GPN D G TP+H AA G+ + VLL D + +K C
Sbjct: 64 LLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCY-------- 115
Query: 807 PLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPT 866
PL +A IVR LI H+G S + ++ + D +ALH A + EV
Sbjct: 116 PLHLAAWKGDAQIVRLLI-----HQGPSHTR--VNEQNNDNETALHCAAQYGHTEV---- 164
Query: 867 ADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMI-AHISTADVSRALNRQ 925
VK L+E D +++ + ET A+ G +V+ ++ AH +
Sbjct: 165 -----VKVLLEELTDPTMRN-NKFETPLDLAALYGRLEVVKMLLNAHPNLLSC------- 211
Query: 926 NSIGWTPLLIACHRGHMQLVNTLLTNHARVDV-FDVEGRSALHLAAEHGYLQVCDALLTN 984
N+ TPL +A GH +V LL A +D + E SALH AA G V LL
Sbjct: 212 NTKKHTPLHLAARNGHKAVVQVLLD--AGMDSNYQTEMGSALHEAALFGKTDVVQILLAA 269
Query: 985 KAFINSKARNGRTAL 999
+N K +G TAL
Sbjct: 270 GTDVNIKDNHGLTAL 284
Score = 50.4 bits (115), Expect = 7e-05
Identities = 61/230 (26%), Positives = 101/230 (43%), Gaps = 33/230 (14%)
Query: 685 KGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGD 744
+G +V+ + YT LH A + VVE LL A ++ K PLH+AA D
Sbjct: 69 RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCY-PLHLAAWKGDAQ 127
Query: 745 KCALMLLK--SGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDP-LRKTKVCIYDV 801
L++ + S N+ D T +H AA++G+ + +LLE+ DP +R K
Sbjct: 128 IVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKF----- 182
Query: 802 VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEE 861
ETPL +A ++V+ L+ H + + + + LH A +
Sbjct: 183 ---ETPLDLAALYGRLEVVKMLL---NAHPN-------LLSCNTKKHTPLHLAAR----- 224
Query: 862 VKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIA 911
+ VV+ L++ G D + QT +A H A+ G DV+ ++A
Sbjct: 225 ----NGHKAVVQVLLDAGMDSNYQTEMG--SALHEAALFGKTDVVQILLA 268
Score = 48.8 bits (111), Expect = 2e-04
Identities = 22/67 (32%), Positives = 36/67 (53%)
Query: 1335 QGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDV 1394
+G +N D G+TPLH AA GH +VV++L + A + C P+ AA + +
Sbjct: 69 RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
Query: 1395 LEYLLHK 1401
+ L+H+
Sbjct: 129 VRLLIHQ 135
Score = 45.6 bits (103), Expect = 0.002
Identities = 59/230 (25%), Positives = 94/230 (40%), Gaps = 34/230 (14%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA GH ++ LL+ +V + LH+A +V L+ G
Sbjct: 80 GYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPS- 138
Query: 723 HIRGGKQ---RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
H R +Q ET LH AA+ + +LL+ P TP+ +AA +G L
Sbjct: 139 HTRVNEQNNDNETALHCAAQY-GHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEV 197
Query: 780 LVLLLEDGGDPLR-KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ +LL + L TK TPL +A R+ +V+ L++ D ++
Sbjct: 198 VKMLLNAHPNLLSCNTK--------KHTPLHLAARNGHKAVVQVLLDAGMDSNYQT---- 245
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRH 888
+ SALH A K + VV+ L+ G DV+++ H
Sbjct: 246 -------EMGSALHEAALFGKTD---------VVQILLAAGTDVNIKDNH 279
Score = 39.5 bits (88), Expect = 0.13
Identities = 34/128 (26%), Positives = 56/128 (43%), Gaps = 5/128 (3%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA YG + ++ LL ++ +T LH+A + AVV+ LL G D + + +
Sbjct: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQ--TE 246
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT--LVLLLEDG 787
+ LH AA D +LL +G N G+T + + + + + L+ED
Sbjct: 247 MGSALHEAALFGKTD-VVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDH 305
Query: 788 GDPLRKTK 795
R TK
Sbjct: 306 MTGKRSTK 313
>AL591002-1|CAI15138.1| 1134|Homo sapiens ankyrin repeat and sterile
alpha motif domain containing 1A protein.
Length = 1134
Score = 97.9 bits (233), Expect = 3e-19
Identities = 72/222 (32%), Positives = 106/222 (47%), Gaps = 7/222 (3%)
Query: 955 VDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
V+ D G + LH AA +G+ V + LL N A N G LHLAA G A +V+ L
Sbjct: 73 VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 132
Query: 1015 IRD--HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN 1072
I + ++ +T LH AA G EV K+LLE + + + P+ AA
Sbjct: 133 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALY 192
Query: 1073 NYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLND 1132
EVV++ L HPNL+ TK +T H+AA G V++ L+ + + +
Sbjct: 193 GRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAARNGHKAVVQVLLDAG----MDSNYQTEM 247
Query: 1133 STPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ L AA G DVV++L+ AG ++ GLTA+ E
Sbjct: 248 GSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRE 289
Score = 96.3 bits (229), Expect = 1e-18
Identities = 66/198 (33%), Positives = 101/198 (51%), Gaps = 6/198 (3%)
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
+N +S G+TPL A GH +V LL N A +V D +G LHLAA G Q+ L
Sbjct: 73 VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 132
Query: 982 L---TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
+ + +N + + TALH AA G+ +VK L+ + + K +TPL LAA
Sbjct: 133 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPT-MRNNKFETPLDLAAL 191
Query: 1039 SGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNT 1098
G++EV K+LL N+ + + P+H AA+N + VVQ+ L + T + +
Sbjct: 192 YGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQT--EMGS 249
Query: 1099 CAHIAAIQGSVKVIEELM 1116
H AA+ G V++ L+
Sbjct: 250 ALHEAALFGKTDVVQILL 267
Score = 92.7 bits (220), Expect = 1e-17
Identities = 71/223 (31%), Positives = 108/223 (48%), Gaps = 20/223 (8%)
Query: 1157 SCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRE 1216
+C D G T +H AA +GH +V++V+ + L + G PLH+AA+ G A+ VR
Sbjct: 74 NCVDST--GYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRL 131
Query: 1217 LLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASN 1276
L+ P + T LH AA G+ VV++LL D
Sbjct: 132 LIHQGPSHTRVNEQN----------NDNETALHCAAQYGHTEVVKVLLEEL---TDPTMR 178
Query: 1277 ENGY-NPLHLACFGGHMSIVGLLLSRSAELLH-STDRHGKTGLHIASTHGHYQMVEVLLG 1334
N + PL LA G + +V +LL+ LL +T +H T LH+A+ +GH +V+VLL
Sbjct: 179 NNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKH--TPLHLAARNGHKAVVQVLLD 236
Query: 1335 QGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETN 1377
G + N + G + LH AA G +VV++L +G + N
Sbjct: 237 AGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDN 278
Score = 91.5 bits (217), Expect = 3e-17
Identities = 70/220 (31%), Positives = 103/220 (46%), Gaps = 20/220 (9%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM--RSTNTLR 1191
TPL AA GH DVV VL+R A + G +HLAA G ++ ++ + + R
Sbjct: 82 TPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTR 141
Query: 1192 ISSKKL-GLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHL 1250
++ + T LH AA YG E V+ LL + P + TPL L
Sbjct: 142 VNEQNNDNETALHCAAQYGHTEVVKVLLEELTD-------------PTMRNNKFETPLDL 188
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AA G VV++LLN+ N + PLHLA GH ++V +LL + + T+
Sbjct: 189 AALYGRLEVVKMLLNAHPNLLSC--NTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTE 246
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPL 1350
+ LH A+ G +V++LL G ++N D +G T L
Sbjct: 247 MG--SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
Score = 89.8 bits (213), Expect = 9e-17
Identities = 88/291 (30%), Positives = 135/291 (46%), Gaps = 32/291 (10%)
Query: 1113 EELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA 1172
+EL++ RTG + A KL L GG G + GL +
Sbjct: 5 QELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGGSG----GGGGGSGGGGGGLGS---- 56
Query: 1173 AEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
+ H +++L + R N + S G TPLH AA G + V LL +++A T
Sbjct: 57 SSHPLSSLLSMWRGPNVNCVDST--GYTPLHHAALNGHKDVVEVLL-------RNDALTN 107
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNP--LHLACFGG 1290
V+ G PLHLAA+ G+ +VRLL++ G + +N N LH A G
Sbjct: 108 VA------DSKGCYPLHLAAWKGDAQIVRLLIHQ-GPSHTRVNEQNNDNETALHCAAQYG 160
Query: 1291 HMSIVGLLLSRSAELLHSTDRHGK--TGLHIASTHGHYQMVEVLLGQGAEINATDKNGWT 1348
H +V +LL EL T R+ K T L +A+ +G ++V++LL + + + T
Sbjct: 161 HTEVVKVLLE---ELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHT 217
Query: 1349 PLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
PLH AA+ GH VV++L ++G +T + A + AA DV++ LL
Sbjct: 218 PLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSA-LHEAALFGKTDVVQILL 267
Score = 85.0 bits (201), Expect = 3e-15
Identities = 57/165 (34%), Positives = 86/165 (52%), Gaps = 4/165 (2%)
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR- 1301
+G TPLH AA NG+++VV +LL + + A S G PLHLA + G IV LL+ +
Sbjct: 79 TGYTPLHHAALNGHKDVVEVLLRNDALTNVADSK--GCYPLHLAAWKGDAQIVRLLIHQG 136
Query: 1302 -SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
S ++ + +T LH A+ +GH ++V+VLL + + + TPL AA G L
Sbjct: 137 PSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLE 196
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
VVK+L + + S P+ AA H V++ LL D+
Sbjct: 197 VVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDS 241
Score = 77.0 bits (181), Expect = 7e-13
Identities = 50/170 (29%), Positives = 85/170 (50%), Gaps = 3/170 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELL-SAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+G PL LA G+ +VR L+ + ++ +TALH AA+ ++ ++L++
Sbjct: 112 KGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEE 171
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
N +TPL +AA G +VK N + + TP+HLAA NGH A++
Sbjct: 172 LTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVV 231
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
++L D S ++ T+ GS L H A+L G D +L G +++ + +
Sbjct: 232 QVLLDAGMDSNYQ-TEMGSAL-HEAALFGKTDVVQILLAAGTDVNIKDNH 279
Score = 76.6 bits (180), Expect = 9e-13
Identities = 65/225 (28%), Positives = 105/225 (46%), Gaps = 16/225 (7%)
Query: 1052 GANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKV 1111
G N++ D G P+H AA N + +VV++ L+ +A +K G H+AA +G ++
Sbjct: 70 GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSK-GCYPLHLAAWKGDAQI 128
Query: 1112 IEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHL 1171
+ L+ + ++ T L AA+ GH +VV+VL+ T N T + L
Sbjct: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
Query: 1172 AAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT 1231
AA +G V+ ++ + + +S TPLH+AA G V+ LL + S T
Sbjct: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLD---AGMDSNYQT 245
Query: 1232 GVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASN 1276
E G + LH AA G +VV++LL +AG + N
Sbjct: 246 ----------EMG-SALHEAALFGKTDVVQILL-AAGTDVNIKDN 278
Score = 60.1 bits (139), Expect = 8e-08
Identities = 40/112 (35%), Positives = 54/112 (48%), Gaps = 5/112 (4%)
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D G T LH A+ +GH +VEVLL A N D G PLH AA G +V+LL
Sbjct: 73 VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 132
Query: 1366 CESGAS---PKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRF 1414
G S + N N + AA H +V++ LL E T M + +F
Sbjct: 133 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLL--EELTDPTMRNNKF 182
Score = 59.7 bits (138), Expect = 1e-07
Identities = 42/129 (32%), Positives = 67/129 (51%), Gaps = 5/129 (3%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
D ++H AA+YGH ++ LL++ + N T L +A + VV+ LL +
Sbjct: 148 DNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPN 207
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCAL-MLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
+ + ++ TPLH+AAR +G K + +LL +G N TE G + +H AA FG +
Sbjct: 208 L-LSCNTKKHTPLHLAAR--NGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKTDVV 263
Query: 781 VLLLEDGGD 789
+LL G D
Sbjct: 264 QILLAAGTD 272
Score = 59.3 bits (137), Expect = 1e-07
Identities = 38/127 (29%), Positives = 60/127 (47%), Gaps = 2/127 (1%)
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G V+ + G TPLH AA G + +V+ A +AD++ P+HLAA G A I+
Sbjct: 70 GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
Query: 181 ELLADK--FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDE 238
LL + + E+ D T +H A+ GH + +L ++ M N FE
Sbjct: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
Query: 239 VLFVKIE 245
L+ ++E
Sbjct: 190 ALYGRLE 196
Score = 56.4 bits (130), Expect = 1e-06
Identities = 40/141 (28%), Positives = 63/141 (44%), Gaps = 8/141 (5%)
Query: 82 LLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAE 141
LLS + G T LH AA D+ +L+ A+ + + G PLH+AA +
Sbjct: 64 LLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWK 123
Query: 142 GDEPLVKYFY-----GVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTK 196
GD +V+ R N DNE T +H AA+ GH ++++L ++ K
Sbjct: 124 GDAQIVRLLIHQGPSHTRVNEQNNDNE--TALHCAAQYGHTEVVKVLLEELTDPTMRNNK 181
Query: 197 DGSTLMHIASLNGHADCAMML 217
T + +A+L G + ML
Sbjct: 182 -FETPLDLAALYGRLEVVKML 201
Score = 54.4 bits (125), Expect = 4e-06
Identities = 78/255 (30%), Positives = 109/255 (42%), Gaps = 39/255 (15%)
Query: 750 LLKSGAGPNKATED--GMTPVHVAAKFGNLATL-VLLLEDGGDPLRKTKVCIYDVVTGET 806
LL GPN D G TP+H AA G+ + VLL D + +K C
Sbjct: 64 LLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCY-------- 115
Query: 807 PLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPT 866
PL +A IVR LI H+G S + ++ + D +ALH A + EV
Sbjct: 116 PLHLAAWKGDAQIVRLLI-----HQGPSHTR--VNEQNNDNETALHCAAQYGHTEV---- 164
Query: 867 ADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMI-AHISTADVSRALNRQ 925
VK L+E D +++ + ET A+ G +V+ ++ AH +
Sbjct: 165 -----VKVLLEELTDPTMRN-NKFETPLDLAALYGRLEVVKMLLNAHPNLLSC------- 211
Query: 926 NSIGWTPLLIACHRGHMQLVNTLLTNHARVDV-FDVEGRSALHLAAEHGYLQVCDALLTN 984
N+ TPL +A GH +V LL A +D + E SALH AA G V LL
Sbjct: 212 NTKKHTPLHLAARNGHKAVVQVLLD--AGMDSNYQTEMGSALHEAALFGKTDVVQILLAA 269
Query: 985 KAFINSKARNGRTAL 999
+N K +G TAL
Sbjct: 270 GTDVNIKDNHGLTAL 284
Score = 50.4 bits (115), Expect = 7e-05
Identities = 61/230 (26%), Positives = 101/230 (43%), Gaps = 33/230 (14%)
Query: 685 KGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGD 744
+G +V+ + YT LH A + VVE LL A ++ K PLH+AA D
Sbjct: 69 RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCY-PLHLAAWKGDAQ 127
Query: 745 KCALMLLK--SGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDP-LRKTKVCIYDV 801
L++ + S N+ D T +H AA++G+ + +LLE+ DP +R K
Sbjct: 128 IVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKF----- 182
Query: 802 VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEE 861
ETPL +A ++V+ L+ H + + + + LH A +
Sbjct: 183 ---ETPLDLAALYGRLEVVKMLL---NAHPN-------LLSCNTKKHTPLHLAAR----- 224
Query: 862 VKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIA 911
+ VV+ L++ G D + QT +A H A+ G DV+ ++A
Sbjct: 225 ----NGHKAVVQVLLDAGMDSNYQTEMG--SALHEAALFGKTDVVQILLA 268
Score = 48.8 bits (111), Expect = 2e-04
Identities = 22/67 (32%), Positives = 36/67 (53%)
Query: 1335 QGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDV 1394
+G +N D G+TPLH AA GH +VV++L + A + C P+ AA + +
Sbjct: 69 RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
Query: 1395 LEYLLHK 1401
+ L+H+
Sbjct: 129 VRLLIHQ 135
Score = 45.6 bits (103), Expect = 0.002
Identities = 59/230 (25%), Positives = 94/230 (40%), Gaps = 34/230 (14%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA GH ++ LL+ +V + LH+A +V L+ G
Sbjct: 80 GYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPS- 138
Query: 723 HIRGGKQ---RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
H R +Q ET LH AA+ + +LL+ P TP+ +AA +G L
Sbjct: 139 HTRVNEQNNDNETALHCAAQY-GHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEV 197
Query: 780 LVLLLEDGGDPLR-KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ +LL + L TK TPL +A R+ +V+ L++ D ++
Sbjct: 198 VKMLLNAHPNLLSCNTK--------KHTPLHLAARNGHKAVVQVLLDAGMDSNYQT---- 245
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRH 888
+ SALH A K + VV+ L+ G DV+++ H
Sbjct: 246 -------EMGSALHEAALFGKTD---------VVQILLAAGTDVNIKDNH 279
Score = 39.5 bits (88), Expect = 0.13
Identities = 34/128 (26%), Positives = 56/128 (43%), Gaps = 5/128 (3%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA YG + ++ LL ++ +T LH+A + AVV+ LL G D + + +
Sbjct: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQ--TE 246
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT--LVLLLEDG 787
+ LH AA D +LL +G N G+T + + + + + L+ED
Sbjct: 247 MGSALHEAALFGKTD-VVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDH 305
Query: 788 GDPLRKTK 795
R TK
Sbjct: 306 MTGKRSTK 313
>AL138721-1|CAI12437.1| 1134|Homo sapiens ankyrin repeat and sterile
alpha motif domain containing 1A protein.
Length = 1134
Score = 97.9 bits (233), Expect = 3e-19
Identities = 72/222 (32%), Positives = 106/222 (47%), Gaps = 7/222 (3%)
Query: 955 VDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
V+ D G + LH AA +G+ V + LL N A N G LHLAA G A +V+ L
Sbjct: 73 VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 132
Query: 1015 IRD--HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN 1072
I + ++ +T LH AA G EV K+LLE + + + P+ AA
Sbjct: 133 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALY 192
Query: 1073 NYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLND 1132
EVV++ L HPNL+ TK +T H+AA G V++ L+ + + +
Sbjct: 193 GRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAARNGHKAVVQVLLDAG----MDSNYQTEM 247
Query: 1133 STPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ L AA G DVV++L+ AG ++ GLTA+ E
Sbjct: 248 GSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRE 289
Score = 96.3 bits (229), Expect = 1e-18
Identities = 66/198 (33%), Positives = 101/198 (51%), Gaps = 6/198 (3%)
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
+N +S G+TPL A GH +V LL N A +V D +G LHLAA G Q+ L
Sbjct: 73 VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 132
Query: 982 L---TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
+ + +N + + TALH AA G+ +VK L+ + + K +TPL LAA
Sbjct: 133 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPT-MRNNKFETPLDLAAL 191
Query: 1039 SGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNT 1098
G++EV K+LL N+ + + P+H AA+N + VVQ+ L + T + +
Sbjct: 192 YGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQT--EMGS 249
Query: 1099 CAHIAAIQGSVKVIEELM 1116
H AA+ G V++ L+
Sbjct: 250 ALHEAALFGKTDVVQILL 267
Score = 92.7 bits (220), Expect = 1e-17
Identities = 71/223 (31%), Positives = 108/223 (48%), Gaps = 20/223 (8%)
Query: 1157 SCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRE 1216
+C D G T +H AA +GH +V++V+ + L + G PLH+AA+ G A+ VR
Sbjct: 74 NCVDST--GYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRL 131
Query: 1217 LLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASN 1276
L+ P + T LH AA G+ VV++LL D
Sbjct: 132 LIHQGPSHTRVNEQN----------NDNETALHCAAQYGHTEVVKVLLEEL---TDPTMR 178
Query: 1277 ENGY-NPLHLACFGGHMSIVGLLLSRSAELLH-STDRHGKTGLHIASTHGHYQMVEVLLG 1334
N + PL LA G + +V +LL+ LL +T +H T LH+A+ +GH +V+VLL
Sbjct: 179 NNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKH--TPLHLAARNGHKAVVQVLLD 236
Query: 1335 QGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETN 1377
G + N + G + LH AA G +VV++L +G + N
Sbjct: 237 AGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDN 278
Score = 91.5 bits (217), Expect = 3e-17
Identities = 70/220 (31%), Positives = 103/220 (46%), Gaps = 20/220 (9%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM--RSTNTLR 1191
TPL AA GH DVV VL+R A + G +HLAA G ++ ++ + + R
Sbjct: 82 TPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTR 141
Query: 1192 ISSKKL-GLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHL 1250
++ + T LH AA YG E V+ LL + P + TPL L
Sbjct: 142 VNEQNNDNETALHCAAQYGHTEVVKVLLEELTD-------------PTMRNNKFETPLDL 188
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AA G VV++LLN+ N + PLHLA GH ++V +LL + + T+
Sbjct: 189 AALYGRLEVVKMLLNAHPNLLSC--NTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTE 246
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPL 1350
+ LH A+ G +V++LL G ++N D +G T L
Sbjct: 247 MG--SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
Score = 89.8 bits (213), Expect = 9e-17
Identities = 88/291 (30%), Positives = 135/291 (46%), Gaps = 32/291 (10%)
Query: 1113 EELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA 1172
+EL++ RTG + A KL L GG G + GL +
Sbjct: 5 QELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGGSG----GGGGGSGGGGGGLGS---- 56
Query: 1173 AEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
+ H +++L + R N + S G TPLH AA G + V LL +++A T
Sbjct: 57 SSHPLSSLLSMWRGPNVNCVDST--GYTPLHHAALNGHKDVVEVLL-------RNDALTN 107
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNP--LHLACFGG 1290
V+ G PLHLAA+ G+ +VRLL++ G + +N N LH A G
Sbjct: 108 VA------DSKGCYPLHLAAWKGDAQIVRLLIHQ-GPSHTRVNEQNNDNETALHCAAQYG 160
Query: 1291 HMSIVGLLLSRSAELLHSTDRHGK--TGLHIASTHGHYQMVEVLLGQGAEINATDKNGWT 1348
H +V +LL EL T R+ K T L +A+ +G ++V++LL + + + T
Sbjct: 161 HTEVVKVLLE---ELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHT 217
Query: 1349 PLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
PLH AA+ GH VV++L ++G +T + A + AA DV++ LL
Sbjct: 218 PLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSA-LHEAALFGKTDVVQILL 267
Score = 85.0 bits (201), Expect = 3e-15
Identities = 57/165 (34%), Positives = 86/165 (52%), Gaps = 4/165 (2%)
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR- 1301
+G TPLH AA NG+++VV +LL + + A S G PLHLA + G IV LL+ +
Sbjct: 79 TGYTPLHHAALNGHKDVVEVLLRNDALTNVADSK--GCYPLHLAAWKGDAQIVRLLIHQG 136
Query: 1302 -SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
S ++ + +T LH A+ +GH ++V+VLL + + + TPL AA G L
Sbjct: 137 PSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLE 196
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
VVK+L + + S P+ AA H V++ LL D+
Sbjct: 197 VVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDS 241
Score = 77.0 bits (181), Expect = 7e-13
Identities = 50/170 (29%), Positives = 85/170 (50%), Gaps = 3/170 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELL-SAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+G PL LA G+ +VR L+ + ++ +TALH AA+ ++ ++L++
Sbjct: 112 KGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEE 171
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
N +TPL +AA G +VK N + + TP+HLAA NGH A++
Sbjct: 172 LTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVV 231
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
++L D S ++ T+ GS L H A+L G D +L G +++ + +
Sbjct: 232 QVLLDAGMDSNYQ-TEMGSAL-HEAALFGKTDVVQILLAAGTDVNIKDNH 279
Score = 76.6 bits (180), Expect = 9e-13
Identities = 65/225 (28%), Positives = 105/225 (46%), Gaps = 16/225 (7%)
Query: 1052 GANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKV 1111
G N++ D G P+H AA N + +VV++ L+ +A +K G H+AA +G ++
Sbjct: 70 GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSK-GCYPLHLAAWKGDAQI 128
Query: 1112 IEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHL 1171
+ L+ + ++ T L AA+ GH +VV+VL+ T N T + L
Sbjct: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
Query: 1172 AAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT 1231
AA +G V+ ++ + + +S TPLH+AA G V+ LL + S T
Sbjct: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLD---AGMDSNYQT 245
Query: 1232 GVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASN 1276
E G + LH AA G +VV++LL +AG + N
Sbjct: 246 ----------EMG-SALHEAALFGKTDVVQILL-AAGTDVNIKDN 278
Score = 60.1 bits (139), Expect = 8e-08
Identities = 40/112 (35%), Positives = 54/112 (48%), Gaps = 5/112 (4%)
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D G T LH A+ +GH +VEVLL A N D G PLH AA G +V+LL
Sbjct: 73 VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 132
Query: 1366 CESGAS---PKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRF 1414
G S + N N + AA H +V++ LL E T M + +F
Sbjct: 133 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLL--EELTDPTMRNNKF 182
Score = 59.7 bits (138), Expect = 1e-07
Identities = 42/129 (32%), Positives = 67/129 (51%), Gaps = 5/129 (3%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
D ++H AA+YGH ++ LL++ + N T L +A + VV+ LL +
Sbjct: 148 DNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPN 207
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCAL-MLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
+ + ++ TPLH+AAR +G K + +LL +G N TE G + +H AA FG +
Sbjct: 208 L-LSCNTKKHTPLHLAAR--NGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKTDVV 263
Query: 781 VLLLEDGGD 789
+LL G D
Sbjct: 264 QILLAAGTD 272
Score = 59.3 bits (137), Expect = 1e-07
Identities = 38/127 (29%), Positives = 60/127 (47%), Gaps = 2/127 (1%)
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G V+ + G TPLH AA G + +V+ A +AD++ P+HLAA G A I+
Sbjct: 70 GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
Query: 181 ELLADK--FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDE 238
LL + + E+ D T +H A+ GH + +L ++ M N FE
Sbjct: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
Query: 239 VLFVKIE 245
L+ ++E
Sbjct: 190 ALYGRLE 196
Score = 56.4 bits (130), Expect = 1e-06
Identities = 40/141 (28%), Positives = 63/141 (44%), Gaps = 8/141 (5%)
Query: 82 LLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAE 141
LLS + G T LH AA D+ +L+ A+ + + G PLH+AA +
Sbjct: 64 LLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWK 123
Query: 142 GDEPLVKYFY-----GVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTK 196
GD +V+ R N DNE T +H AA+ GH ++++L ++ K
Sbjct: 124 GDAQIVRLLIHQGPSHTRVNEQNNDNE--TALHCAAQYGHTEVVKVLLEELTDPTMRNNK 181
Query: 197 DGSTLMHIASLNGHADCAMML 217
T + +A+L G + ML
Sbjct: 182 -FETPLDLAALYGRLEVVKML 201
Score = 54.4 bits (125), Expect = 4e-06
Identities = 78/255 (30%), Positives = 109/255 (42%), Gaps = 39/255 (15%)
Query: 750 LLKSGAGPNKATED--GMTPVHVAAKFGNLATL-VLLLEDGGDPLRKTKVCIYDVVTGET 806
LL GPN D G TP+H AA G+ + VLL D + +K C
Sbjct: 64 LLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCY-------- 115
Query: 807 PLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPT 866
PL +A IVR LI H+G S + ++ + D +ALH A + EV
Sbjct: 116 PLHLAAWKGDAQIVRLLI-----HQGPSHTR--VNEQNNDNETALHCAAQYGHTEV---- 164
Query: 867 ADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMI-AHISTADVSRALNRQ 925
VK L+E D +++ + ET A+ G +V+ ++ AH +
Sbjct: 165 -----VKVLLEELTDPTMRN-NKFETPLDLAALYGRLEVVKMLLNAHPNLLSC------- 211
Query: 926 NSIGWTPLLIACHRGHMQLVNTLLTNHARVDV-FDVEGRSALHLAAEHGYLQVCDALLTN 984
N+ TPL +A GH +V LL A +D + E SALH AA G V LL
Sbjct: 212 NTKKHTPLHLAARNGHKAVVQVLLD--AGMDSNYQTEMGSALHEAALFGKTDVVQILLAA 269
Query: 985 KAFINSKARNGRTAL 999
+N K +G TAL
Sbjct: 270 GTDVNIKDNHGLTAL 284
Score = 50.4 bits (115), Expect = 7e-05
Identities = 61/230 (26%), Positives = 101/230 (43%), Gaps = 33/230 (14%)
Query: 685 KGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGD 744
+G +V+ + YT LH A + VVE LL A ++ K PLH+AA D
Sbjct: 69 RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCY-PLHLAAWKGDAQ 127
Query: 745 KCALMLLK--SGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDP-LRKTKVCIYDV 801
L++ + S N+ D T +H AA++G+ + +LLE+ DP +R K
Sbjct: 128 IVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKF----- 182
Query: 802 VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEE 861
ETPL +A ++V+ L+ H + + + + LH A +
Sbjct: 183 ---ETPLDLAALYGRLEVVKMLL---NAHPN-------LLSCNTKKHTPLHLAAR----- 224
Query: 862 VKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIA 911
+ VV+ L++ G D + QT +A H A+ G DV+ ++A
Sbjct: 225 ----NGHKAVVQVLLDAGMDSNYQTEMG--SALHEAALFGKTDVVQILLA 268
Score = 48.8 bits (111), Expect = 2e-04
Identities = 22/67 (32%), Positives = 36/67 (53%)
Query: 1335 QGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDV 1394
+G +N D G+TPLH AA GH +VV++L + A + C P+ AA + +
Sbjct: 69 RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
Query: 1395 LEYLLHK 1401
+ L+H+
Sbjct: 129 VRLLIHQ 135
Score = 45.6 bits (103), Expect = 0.002
Identities = 59/230 (25%), Positives = 94/230 (40%), Gaps = 34/230 (14%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA GH ++ LL+ +V + LH+A +V L+ G
Sbjct: 80 GYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPS- 138
Query: 723 HIRGGKQ---RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
H R +Q ET LH AA+ + +LL+ P TP+ +AA +G L
Sbjct: 139 HTRVNEQNNDNETALHCAAQY-GHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEV 197
Query: 780 LVLLLEDGGDPLR-KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ +LL + L TK TPL +A R+ +V+ L++ D ++
Sbjct: 198 VKMLLNAHPNLLSCNTK--------KHTPLHLAARNGHKAVVQVLLDAGMDSNYQT---- 245
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRH 888
+ SALH A K + VV+ L+ G DV+++ H
Sbjct: 246 -------EMGSALHEAALFGKTD---------VVQILLAAGTDVNIKDNH 279
Score = 39.5 bits (88), Expect = 0.13
Identities = 34/128 (26%), Positives = 56/128 (43%), Gaps = 5/128 (3%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA YG + ++ LL ++ +T LH+A + AVV+ LL G D + + +
Sbjct: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQ--TE 246
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT--LVLLLEDG 787
+ LH AA D +LL +G N G+T + + + + + L+ED
Sbjct: 247 MGSALHEAALFGKTD-VVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDH 305
Query: 788 GDPLRKTK 795
R TK
Sbjct: 306 MTGKRSTK 313
>AL033520-2|CAI20281.1| 1134|Homo sapiens ankyrin repeat and sterile
alpha motif domain containing 1A protein.
Length = 1134
Score = 97.9 bits (233), Expect = 3e-19
Identities = 72/222 (32%), Positives = 106/222 (47%), Gaps = 7/222 (3%)
Query: 955 VDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFL 1014
V+ D G + LH AA +G+ V + LL N A N G LHLAA G A +V+ L
Sbjct: 73 VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 132
Query: 1015 IRD--HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQN 1072
I + ++ +T LH AA G EV K+LLE + + + P+ AA
Sbjct: 133 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALY 192
Query: 1073 NYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLND 1132
EVV++ L HPNL+ TK +T H+AA G V++ L+ + + +
Sbjct: 193 GRLEVVKMLLNAHPNLLSCNTKK-HTPLHLAARNGHKAVVQVLLDAG----MDSNYQTEM 247
Query: 1133 STPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAE 1174
+ L AA G DVV++L+ AG ++ GLTA+ E
Sbjct: 248 GSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRE 289
Score = 96.3 bits (229), Expect = 1e-18
Identities = 66/198 (33%), Positives = 101/198 (51%), Gaps = 6/198 (3%)
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
+N +S G+TPL A GH +V LL N A +V D +G LHLAA G Q+ L
Sbjct: 73 VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 132
Query: 982 L---TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
+ + +N + + TALH AA G+ +VK L+ + + K +TPL LAA
Sbjct: 133 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPT-MRNNKFETPLDLAAL 191
Query: 1039 SGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNT 1098
G++EV K+LL N+ + + P+H AA+N + VVQ+ L + T + +
Sbjct: 192 YGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQT--EMGS 249
Query: 1099 CAHIAAIQGSVKVIEELM 1116
H AA+ G V++ L+
Sbjct: 250 ALHEAALFGKTDVVQILL 267
Score = 92.7 bits (220), Expect = 1e-17
Identities = 71/223 (31%), Positives = 108/223 (48%), Gaps = 20/223 (8%)
Query: 1157 SCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRE 1216
+C D G T +H AA +GH +V++V+ + L + G PLH+AA+ G A+ VR
Sbjct: 74 NCVDST--GYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRL 131
Query: 1217 LLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASN 1276
L+ P + T LH AA G+ VV++LL D
Sbjct: 132 LIHQGPSHTRVNEQN----------NDNETALHCAAQYGHTEVVKVLLEEL---TDPTMR 178
Query: 1277 ENGY-NPLHLACFGGHMSIVGLLLSRSAELLH-STDRHGKTGLHIASTHGHYQMVEVLLG 1334
N + PL LA G + +V +LL+ LL +T +H T LH+A+ +GH +V+VLL
Sbjct: 179 NNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKH--TPLHLAARNGHKAVVQVLLD 236
Query: 1335 QGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETN 1377
G + N + G + LH AA G +VV++L +G + N
Sbjct: 237 AGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVNIKDN 278
Score = 91.5 bits (217), Expect = 3e-17
Identities = 70/220 (31%), Positives = 103/220 (46%), Gaps = 20/220 (9%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM--RSTNTLR 1191
TPL AA GH DVV VL+R A + G +HLAA G ++ ++ + + R
Sbjct: 82 TPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTR 141
Query: 1192 ISSKKL-GLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHL 1250
++ + T LH AA YG E V+ LL + P + TPL L
Sbjct: 142 VNEQNNDNETALHCAAQYGHTEVVKVLLEELTD-------------PTMRNNKFETPLDL 188
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AA G VV++LLN+ N + PLHLA GH ++V +LL + + T+
Sbjct: 189 AALYGRLEVVKMLLNAHPNLLSC--NTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTE 246
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPL 1350
+ LH A+ G +V++LL G ++N D +G T L
Sbjct: 247 MG--SALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTAL 284
Score = 89.8 bits (213), Expect = 9e-17
Identities = 88/291 (30%), Positives = 135/291 (46%), Gaps = 32/291 (10%)
Query: 1113 EELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA 1172
+EL++ RTG + A KL L GG G + GL +
Sbjct: 5 QELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGGSG----GGGGGSGGGGGGLGS---- 56
Query: 1173 AEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG 1232
+ H +++L + R N + S G TPLH AA G + V LL +++A T
Sbjct: 57 SSHPLSSLLSMWRGPNVNCVDST--GYTPLHHAALNGHKDVVEVLL-------RNDALTN 107
Query: 1233 VSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNP--LHLACFGG 1290
V+ G PLHLAA+ G+ +VRLL++ G + +N N LH A G
Sbjct: 108 VA------DSKGCYPLHLAAWKGDAQIVRLLIHQ-GPSHTRVNEQNNDNETALHCAAQYG 160
Query: 1291 HMSIVGLLLSRSAELLHSTDRHGK--TGLHIASTHGHYQMVEVLLGQGAEINATDKNGWT 1348
H +V +LL EL T R+ K T L +A+ +G ++V++LL + + + T
Sbjct: 161 HTEVVKVLLE---ELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHT 217
Query: 1349 PLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
PLH AA+ GH VV++L ++G +T + A + AA DV++ LL
Sbjct: 218 PLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSA-LHEAALFGKTDVVQILL 267
Score = 85.0 bits (201), Expect = 3e-15
Identities = 57/165 (34%), Positives = 86/165 (52%), Gaps = 4/165 (2%)
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR- 1301
+G TPLH AA NG+++VV +LL + + A S G PLHLA + G IV LL+ +
Sbjct: 79 TGYTPLHHAALNGHKDVVEVLLRNDALTNVADSK--GCYPLHLAAWKGDAQIVRLLIHQG 136
Query: 1302 -SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
S ++ + +T LH A+ +GH ++V+VLL + + + TPL AA G L
Sbjct: 137 PSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLE 196
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
VVK+L + + S P+ AA H V++ LL D+
Sbjct: 197 VVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDS 241
Score = 77.0 bits (181), Expect = 7e-13
Identities = 50/170 (29%), Positives = 85/170 (50%), Gaps = 3/170 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELL-SAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+G PL LA G+ +VR L+ + ++ +TALH AA+ ++ ++L++
Sbjct: 112 KGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEE 171
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
N +TPL +AA G +VK N + + TP+HLAA NGH A++
Sbjct: 172 LTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVV 231
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
++L D S ++ T+ GS L H A+L G D +L G +++ + +
Sbjct: 232 QVLLDAGMDSNYQ-TEMGSAL-HEAALFGKTDVVQILLAAGTDVNIKDNH 279
Score = 76.6 bits (180), Expect = 9e-13
Identities = 65/225 (28%), Positives = 105/225 (46%), Gaps = 16/225 (7%)
Query: 1052 GANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKV 1111
G N++ D G P+H AA N + +VV++ L+ +A +K G H+AA +G ++
Sbjct: 70 GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSK-GCYPLHLAAWKGDAQI 128
Query: 1112 IEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHL 1171
+ L+ + ++ T L AA+ GH +VV+VL+ T N T + L
Sbjct: 129 VRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDL 188
Query: 1172 AAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT 1231
AA +G V+ ++ + + +S TPLH+AA G V+ LL + S T
Sbjct: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLD---AGMDSNYQT 245
Query: 1232 GVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASN 1276
E G + LH AA G +VV++LL +AG + N
Sbjct: 246 ----------EMG-SALHEAALFGKTDVVQILL-AAGTDVNIKDN 278
Score = 60.1 bits (139), Expect = 8e-08
Identities = 40/112 (35%), Positives = 54/112 (48%), Gaps = 5/112 (4%)
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D G T LH A+ +GH +VEVLL A N D G PLH AA G +V+LL
Sbjct: 73 VNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLL 132
Query: 1366 CESGAS---PKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRF 1414
G S + N N + AA H +V++ LL E T M + +F
Sbjct: 133 IHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLL--EELTDPTMRNNKF 182
Score = 59.7 bits (138), Expect = 1e-07
Identities = 42/129 (32%), Positives = 67/129 (51%), Gaps = 5/129 (3%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
D ++H AA+YGH ++ LL++ + N T L +A + VV+ LL +
Sbjct: 148 DNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPN 207
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCAL-MLLKSGAGPNKATEDGMTPVHVAAKFGNLATL 780
+ + ++ TPLH+AAR +G K + +LL +G N TE G + +H AA FG +
Sbjct: 208 L-LSCNTKKHTPLHLAAR--NGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKTDVV 263
Query: 781 VLLLEDGGD 789
+LL G D
Sbjct: 264 QILLAAGTD 272
Score = 59.3 bits (137), Expect = 1e-07
Identities = 38/127 (29%), Positives = 60/127 (47%), Gaps = 2/127 (1%)
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G V+ + G TPLH AA G + +V+ A +AD++ P+HLAA G A I+
Sbjct: 70 GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
Query: 181 ELLADK--FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDE 238
LL + + E+ D T +H A+ GH + +L ++ M N FE
Sbjct: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLA 189
Query: 239 VLFVKIE 245
L+ ++E
Sbjct: 190 ALYGRLE 196
Score = 56.4 bits (130), Expect = 1e-06
Identities = 40/141 (28%), Positives = 63/141 (44%), Gaps = 8/141 (5%)
Query: 82 LLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAE 141
LLS + G T LH AA D+ +L+ A+ + + G PLH+AA +
Sbjct: 64 LLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWK 123
Query: 142 GDEPLVKYFY-----GVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTK 196
GD +V+ R N DNE T +H AA+ GH ++++L ++ K
Sbjct: 124 GDAQIVRLLIHQGPSHTRVNEQNNDNE--TALHCAAQYGHTEVVKVLLEELTDPTMRNNK 181
Query: 197 DGSTLMHIASLNGHADCAMML 217
T + +A+L G + ML
Sbjct: 182 -FETPLDLAALYGRLEVVKML 201
Score = 54.4 bits (125), Expect = 4e-06
Identities = 78/255 (30%), Positives = 109/255 (42%), Gaps = 39/255 (15%)
Query: 750 LLKSGAGPNKATED--GMTPVHVAAKFGNLATL-VLLLEDGGDPLRKTKVCIYDVVTGET 806
LL GPN D G TP+H AA G+ + VLL D + +K C
Sbjct: 64 LLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCY-------- 115
Query: 807 PLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPT 866
PL +A IVR LI H+G S + ++ + D +ALH A + EV
Sbjct: 116 PLHLAAWKGDAQIVRLLI-----HQGPSHTR--VNEQNNDNETALHCAAQYGHTEV---- 164
Query: 867 ADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMI-AHISTADVSRALNRQ 925
VK L+E D +++ + ET A+ G +V+ ++ AH +
Sbjct: 165 -----VKVLLEELTDPTMRN-NKFETPLDLAALYGRLEVVKMLLNAHPNLLSC------- 211
Query: 926 NSIGWTPLLIACHRGHMQLVNTLLTNHARVDV-FDVEGRSALHLAAEHGYLQVCDALLTN 984
N+ TPL +A GH +V LL A +D + E SALH AA G V LL
Sbjct: 212 NTKKHTPLHLAARNGHKAVVQVLLD--AGMDSNYQTEMGSALHEAALFGKTDVVQILLAA 269
Query: 985 KAFINSKARNGRTAL 999
+N K +G TAL
Sbjct: 270 GTDVNIKDNHGLTAL 284
Score = 50.4 bits (115), Expect = 7e-05
Identities = 61/230 (26%), Positives = 101/230 (43%), Gaps = 33/230 (14%)
Query: 685 KGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGD 744
+G +V+ + YT LH A + VVE LL A ++ K PLH+AA D
Sbjct: 69 RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCY-PLHLAAWKGDAQ 127
Query: 745 KCALMLLK--SGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDP-LRKTKVCIYDV 801
L++ + S N+ D T +H AA++G+ + +LLE+ DP +R K
Sbjct: 128 IVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKF----- 182
Query: 802 VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEE 861
ETPL +A ++V+ L+ H + + + + LH A +
Sbjct: 183 ---ETPLDLAALYGRLEVVKMLL---NAHPN-------LLSCNTKKHTPLHLAAR----- 224
Query: 862 VKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIA 911
+ VV+ L++ G D + QT +A H A+ G DV+ ++A
Sbjct: 225 ----NGHKAVVQVLLDAGMDSNYQTEMG--SALHEAALFGKTDVVQILLA 268
Score = 48.8 bits (111), Expect = 2e-04
Identities = 22/67 (32%), Positives = 36/67 (53%)
Query: 1335 QGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDV 1394
+G +N D G+TPLH AA GH +VV++L + A + C P+ AA + +
Sbjct: 69 RGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQI 128
Query: 1395 LEYLLHK 1401
+ L+H+
Sbjct: 129 VRLLIHQ 135
Score = 45.6 bits (103), Expect = 0.002
Identities = 59/230 (25%), Positives = 94/230 (40%), Gaps = 34/230 (14%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G +H AA GH ++ LL+ +V + LH+A +V L+ G
Sbjct: 80 GYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPS- 138
Query: 723 HIRGGKQ---RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
H R +Q ET LH AA+ + +LL+ P TP+ +AA +G L
Sbjct: 139 HTRVNEQNNDNETALHCAAQY-GHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEV 197
Query: 780 LVLLLEDGGDPLR-KTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
+ +LL + L TK TPL +A R+ +V+ L++ D ++
Sbjct: 198 VKMLLNAHPNLLSCNTK--------KHTPLHLAARNGHKAVVQVLLDAGMDSNYQT---- 245
Query: 839 FIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRH 888
+ SALH A K + VV+ L+ G DV+++ H
Sbjct: 246 -------EMGSALHEAALFGKTD---------VVQILLAAGTDVNIKDNH 279
Score = 39.5 bits (88), Expect = 0.13
Identities = 34/128 (26%), Positives = 56/128 (43%), Gaps = 5/128 (3%)
Query: 670 AARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQ 729
AA YG + ++ LL ++ +T LH+A + AVV+ LL G D + + +
Sbjct: 189 AALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQ--TE 246
Query: 730 RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT--LVLLLEDG 787
+ LH AA D +LL +G N G+T + + + + + L+ED
Sbjct: 247 MGSALHEAALFGKTD-VVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAALIEDH 305
Query: 788 GDPLRKTK 795
R TK
Sbjct: 306 MTGKRSTK 313
>BC024189-1|AAH24189.2| 345|Homo sapiens fibronectin type III and
ankyrin repeat domains 1 protein.
Length = 345
Score = 97.1 bits (231), Expect = 6e-19
Identities = 64/199 (32%), Positives = 106/199 (53%), Gaps = 5/199 (2%)
Query: 926 NSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNK 985
N G+T L++A +G+ +LV L++N V++ + G+ +L LA G+L V L +
Sbjct: 141 NKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHG 200
Query: 986 AFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVL-TLKKQTPL-HLAAASGQIE 1043
A ++ G TALH AA G+ +++++I+D +DV+ T TPL ++A SG
Sbjct: 201 ASWQARDLGGCTALHWAADGGHCSVIEWMIKD-GCEVDVVDTGSGWTPLMRVSAVSGNQR 259
Query: 1044 VCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT--KDGNTCAH 1101
V LL++ GAN++ D G+ P+ A NN+ E+VQL L + + + K A
Sbjct: 260 VASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMAR 319
Query: 1102 IAAIQGSVKVIEELMKFDR 1120
+ Q V ++EE K R
Sbjct: 320 VFDRQSVVSLLEERKKKQR 338
Score = 86.2 bits (204), Expect = 1e-15
Identities = 52/163 (31%), Positives = 86/163 (52%), Gaps = 5/163 (3%)
Query: 1244 GLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSA 1303
G T L +AA G +V++L+++ G + N +G + L LAC+ GH+ +V L A
Sbjct: 144 GFTALMVAAQKGYTRLVKILVSN-GTDVNL-KNGSGKDSLMLACYAGHLDVVKYLRRHGA 201
Query: 1304 ELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDK-NGWTPL-HCAAKAGHLNV 1361
+ D G T LH A+ GH ++E ++ G E++ D +GWTPL +A +G+ V
Sbjct: 202 SW-QARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRV 260
Query: 1362 VKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
LL ++GA+ + P+ A NH ++++ LL K D
Sbjct: 261 ASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGAD 303
Score = 77.0 bits (181), Expect = 7e-13
Identities = 62/235 (26%), Positives = 107/235 (45%), Gaps = 16/235 (6%)
Query: 1147 VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
+VR+L N+ G TA+ +AA+ G+T ++ ++ S T G L +A
Sbjct: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLAC 185
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS 1266
Y G + V+ L H G G G T LH AA G+ +V+ ++
Sbjct: 186 YAGHLDVVKYLRRH--GASWQARDLG-----------GCTALHWAADGGHCSVIEWMIKD 232
Query: 1267 AGVQADAASNENGYNPL-HLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGH 1325
G + D +G+ PL ++ G+ + LL+ A + + DR+GKT L +A + H
Sbjct: 233 -GCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANV-NVKDRNGKTPLMVAVLNNH 290
Query: 1326 YQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNC 1380
++V++LL +GA+ + ++ G L A +VV LL E + + + C
Sbjct: 291 EELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEERKKKQRPKKSCVC 345
Score = 72.9 bits (171), Expect = 1e-11
Identities = 77/271 (28%), Positives = 121/271 (44%), Gaps = 24/271 (8%)
Query: 1033 LHLAAASGQIEVCKLLLELGANIDATDE-LGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
L + + SG+ E L+ ++ T E + + +H A N +++ LQ V
Sbjct: 85 LKVTSPSGECEYSPLV-----SVSTTREPISSEHLHRAVSVNDEDLLVRILQGGRVKVDV 139
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
K G T +AA +G ++++ L+ + T V DS L LA GH DVV+ L
Sbjct: 140 PNKFGFTALMVAAQKGYTRLVKILVS-NGTDVNLKNGSGKDS--LMLACYAGHLDVVKYL 196
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLD-VMRSTNTLRISSKKLGLTPLHIAAYYGQ 1210
R GAS + G TA+H AA+ GH +V++ +++ + + G TPL +
Sbjct: 197 RRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSG 256
Query: 1211 AETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQ 1270
+ V LL V + +G TPL +A N +E +V+LLL+ G
Sbjct: 257 NQRVASLLIDAGANVN------------VKDRNGKTPLMVAVLNNHEELVQLLLDK-GAD 303
Query: 1271 ADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
A + NE G L +A S+V LL R
Sbjct: 304 A-SVKNEFGKGVLEMARVFDRQSVVSLLEER 333
Score = 69.7 bits (163), Expect = 1e-10
Identities = 58/210 (27%), Positives = 98/210 (46%), Gaps = 7/210 (3%)
Query: 944 LVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAA 1003
LV L +VDV + G +AL +AA+ GY ++ L++N +N K +G+ +L LA
Sbjct: 126 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLAC 185
Query: 1004 MNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDE-LG 1062
G+ +VK+L R H A L T LH AA G V + +++ G +D D G
Sbjct: 186 YAGHLDVVKYL-RRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSG 244
Query: 1063 QKPI-HAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
P+ +A + V L + N V ++G T +A + ++++ L+ D+
Sbjct: 245 WTPLMRVSAVSGNQRVASLLIDAGAN-VNVKDRNGKTPLMVAVLNNHEELVQLLL--DKG 301
Query: 1122 GVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
S +N+ L++A VV +L
Sbjct: 302 ADASVKNEFGKGV-LEMARVFDRQSVVSLL 330
Score = 66.9 bits (156), Expect = 7e-10
Identities = 46/161 (28%), Positives = 83/161 (51%), Gaps = 3/161 (1%)
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
+N +N G L++AC+ GH+ +V L + A D+ G +ALH AA+ G+ V + +
Sbjct: 170 VNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWM 229
Query: 982 LTNKAFIN-SKARNGRTAL-HLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAAS 1039
+ + ++ +G T L ++A++G + LI D A ++V +TPL +A +
Sbjct: 230 IKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI-DAGANVNVKDRNGKTPLMVAVLN 288
Query: 1040 GQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQL 1080
E+ +LLL+ GA+ +E G+ + A + VV L
Sbjct: 289 NHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSL 329
Score = 62.1 bits (144), Expect = 2e-08
Identities = 37/133 (27%), Positives = 70/133 (52%), Gaps = 1/133 (0%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G TAL +AA++ + +ILV G V+ NG+G+ L +A G +VKY A+
Sbjct: 144 GFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASW 203
Query: 158 AIADNEDRTPMHLAAENGHAAIIE-LLADKFKASIFERTKDGSTLMHIASLNGHADCAMM 216
D T +H AA+ GH ++IE ++ D + + + + LM +++++G+ A +
Sbjct: 204 QARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASL 263
Query: 217 LFKKGVYLHMPNK 229
L G +++ ++
Sbjct: 264 LIDAGANVNVKDR 276
Score = 59.3 bits (137), Expect = 1e-07
Identities = 37/122 (30%), Positives = 62/122 (50%), Gaps = 2/122 (1%)
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH A +E+++ +L V+ D N+ G+ L +A G+ +V +L+S ++ +
Sbjct: 114 LHRAVSVNDEDLLVRILQGGRVKVDVP-NKFGFTALMVAAQKGYTRLVKILVSNGTDV-N 171
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
+ GK L +A GH +V+ L GA A D G T LH AA GH +V++ + +
Sbjct: 172 LKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIK 231
Query: 1368 SG 1369
G
Sbjct: 232 DG 233
Score = 58.8 bits (136), Expect = 2e-07
Identities = 52/183 (28%), Positives = 86/183 (46%), Gaps = 10/183 (5%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
++VK L+ NG DV+L+ ++ C AG+ DV+ + H + +R L ++
Sbjct: 158 RLVKILVSNGTDVNLKNGSGKDSLMLAC-YAGHLDVVKYLRRH-GASWQARDLGGCTALH 215
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDV-EGRSAL-HLAAEHGYLQVCDALLTNKAF 987
W A GH ++ ++ + VDV D G + L ++A G +V L+ A
Sbjct: 216 W-----AADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGAN 270
Query: 988 INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKL 1047
+N K RNG+T L +A +N + LV+ L+ D A V + L +A + V L
Sbjct: 271 VNVKDRNGKTPLMVAVLNNHEELVQLLL-DKGADASVKNEFGKGVLEMARVFDRQSVVSL 329
Query: 1048 LLE 1050
L E
Sbjct: 330 LEE 332
Score = 58.4 bits (135), Expect = 3e-07
Identities = 29/90 (32%), Positives = 52/90 (57%)
Query: 1310 DRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESG 1369
++ G T L +A+ G+ ++V++L+ G ++N + +G L A AGHL+VVK L G
Sbjct: 141 NKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHG 200
Query: 1370 ASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
AS ++ C + +AA H V+E+++
Sbjct: 201 ASWQARDLGGCTALHWAADGGHCSVIEWMI 230
Score = 57.6 bits (133), Expect = 4e-07
Identities = 46/170 (27%), Positives = 81/170 (47%), Gaps = 5/170 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L++A + G +V+ L+S T LK +G +L LA +D+ + L +GA
Sbjct: 144 GFTALMVAAQKGYTRLVKILVSNGTDVNLK--NGSGKDSLMLACYAGHLDVVKYLRRHGA 201
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TP-MHLAAENGHAAII 180
A + G T LH AA G ++++ + D TP M ++A +G+ +
Sbjct: 202 SWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVA 261
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
LL D A++ + ++G T + +A LN H + +L KG + N++
Sbjct: 262 SLLIDA-GANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEF 310
Score = 55.6 bits (128), Expect = 2e-06
Identities = 36/131 (27%), Positives = 60/131 (45%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ G S+ A GH+ ++ L + G S TALH A + +V+E ++
Sbjct: 173 KNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKD 232
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
G +V + TPL + + + A +L+ +GA N +G TP+ VA +
Sbjct: 233 GCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEE 292
Query: 779 TLVLLLEDGGD 789
+ LLL+ G D
Sbjct: 293 LVQLLLDKGAD 303
Score = 54.0 bits (124), Expect = 5e-06
Identities = 49/216 (22%), Positives = 94/216 (43%), Gaps = 2/216 (0%)
Query: 999 LHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDAT 1058
LH A L+ +++ +DV T L +AA G + K+L+ G +++
Sbjct: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
Query: 1059 DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKF 1118
+ G+ + A + +VV+ +L++H A G T H AA G VIE ++K
Sbjct: 174 NGSGKDSLMLACYAGHLDVVK-YLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIK- 231
Query: 1119 DRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHT 1178
D V + ++++A G+ V +L+ AGA+ ++R G T + +A + H
Sbjct: 232 DGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHE 291
Query: 1179 NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETV 1214
++ ++ + G L +A + + V
Sbjct: 292 ELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVV 327
Score = 46.8 bits (106), Expect = 8e-04
Identities = 37/127 (29%), Positives = 52/127 (40%), Gaps = 2/127 (1%)
Query: 96 PAGDTALHLAARRRDVDM-ARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVR 154
P LH A D D+ RIL VD N G T L +AA +G LVK
Sbjct: 108 PISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNG 167
Query: 155 ANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCA 214
+ + + + + LA GH +++ L + AS R G T +H A+ GH
Sbjct: 168 TDVNLKNGSGKDSLMLACYAGHLDVVKYLR-RHGASWQARDLGGCTALHWAADGGHCSVI 226
Query: 215 MMLFKKG 221
+ K G
Sbjct: 227 EWMIKDG 233
Score = 44.8 bits (101), Expect = 0.003
Identities = 38/143 (26%), Positives = 66/143 (46%), Gaps = 9/143 (6%)
Query: 667 IHTAARYGHVGIINTLLQKGE-SVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+H A ++ +LQ G VDV +TAL +A + +V+ L+ G DV+++
Sbjct: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
G +++ L +A D L + GA G T +H AA G+ + + +++
Sbjct: 174 NGSGKDS-LMLACYAGHLD-VVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIK 231
Query: 786 DGGDPLRKTKVCIYDVVTGETPL 808
DG +V + D +G TPL
Sbjct: 232 DG------CEVDVVDTGSGWTPL 248
Score = 39.9 bits (89), Expect = 0.096
Identities = 24/83 (28%), Positives = 41/83 (49%), Gaps = 1/83 (1%)
Query: 1317 LHIA-STHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSE 1375
LH A S + +V +L G +++ +K G+T L AA+ G+ +VK+L +G +
Sbjct: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
Query: 1376 TNLNCAPIWFAASENHNDVLEYL 1398
+ A H DV++YL
Sbjct: 174 NGSGKDSLMLACYAGHLDVVKYL 196
Score = 39.9 bits (89), Expect = 0.096
Identities = 27/126 (21%), Positives = 58/126 (46%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + G+ S++ ++ + T + ++A + +A +L+D GA
Sbjct: 210 GCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGA 269
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+ + G+TPL +A E LV+ A+A++ + + + +A +++ L
Sbjct: 270 NVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSL 329
Query: 183 LADKFK 188
L ++ K
Sbjct: 330 LEERKK 335
>AY358154-1|AAQ88521.1| 371|Homo sapiens CG3104 hlg protein.
Length = 371
Score = 97.1 bits (231), Expect = 6e-19
Identities = 64/199 (32%), Positives = 106/199 (53%), Gaps = 5/199 (2%)
Query: 926 NSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNK 985
N G+T L++A +G+ +LV L++N V++ + G+ +L LA G+L V L +
Sbjct: 167 NKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHG 226
Query: 986 AFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVL-TLKKQTPL-HLAAASGQIE 1043
A ++ G TALH AA G+ +++++I+D +DV+ T TPL ++A SG
Sbjct: 227 ASWQARDLGGCTALHWAADGGHCSVIEWMIKD-GCEVDVVDTGSGWTPLMRVSAVSGNQR 285
Query: 1044 VCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT--KDGNTCAH 1101
V LL++ GAN++ D G+ P+ A NN+ E+VQL L + + + K A
Sbjct: 286 VASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMAR 345
Query: 1102 IAAIQGSVKVIEELMKFDR 1120
+ Q V ++EE K R
Sbjct: 346 VFDRQSVVSLLEERKKKQR 364
Score = 86.2 bits (204), Expect = 1e-15
Identities = 52/163 (31%), Positives = 86/163 (52%), Gaps = 5/163 (3%)
Query: 1244 GLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSA 1303
G T L +AA G +V++L+++ G + N +G + L LAC+ GH+ +V L A
Sbjct: 170 GFTALMVAAQKGYTRLVKILVSN-GTDVNL-KNGSGKDSLMLACYAGHLDVVKYLRRHGA 227
Query: 1304 ELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDK-NGWTPL-HCAAKAGHLNV 1361
+ D G T LH A+ GH ++E ++ G E++ D +GWTPL +A +G+ V
Sbjct: 228 SW-QARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRV 286
Query: 1362 VKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
LL ++GA+ + P+ A NH ++++ LL K D
Sbjct: 287 ASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGAD 329
Score = 77.0 bits (181), Expect = 7e-13
Identities = 62/235 (26%), Positives = 107/235 (45%), Gaps = 16/235 (6%)
Query: 1147 VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAA 1206
+VR+L N+ G TA+ +AA+ G+T ++ ++ S T G L +A
Sbjct: 152 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLAC 211
Query: 1207 YYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS 1266
Y G + V+ L H G G G T LH AA G+ +V+ ++
Sbjct: 212 YAGHLDVVKYLRRH--GASWQARDLG-----------GCTALHWAADGGHCSVIEWMIKD 258
Query: 1267 AGVQADAASNENGYNPL-HLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGH 1325
G + D +G+ PL ++ G+ + LL+ A + + DR+GKT L +A + H
Sbjct: 259 -GCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANV-NVKDRNGKTPLMVAVLNNH 316
Query: 1326 YQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNC 1380
++V++LL +GA+ + ++ G L A +VV LL E + + + C
Sbjct: 317 EELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEERKKKQRPKKSCVC 371
Score = 71.7 bits (168), Expect = 3e-11
Identities = 70/244 (28%), Positives = 109/244 (44%), Gaps = 18/244 (7%)
Query: 1059 DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKF 1118
+ + + +H A N +++ LQ V K G T +AA +G ++++ L+
Sbjct: 133 EPISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVS- 191
Query: 1119 DRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHT 1178
+ T V DS L LA GH DVV+ L R GAS + G TA+H AA+ GH
Sbjct: 192 NGTDVNLKNGSGKDS--LMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHC 249
Query: 1179 NVLD-VMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVP 1237
+V++ +++ + + G TPL + + V LL V
Sbjct: 250 SVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVN----------- 298
Query: 1238 VLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGL 1297
+ +G TPL +A N +E +V+LLL+ G A + NE G L +A S+V L
Sbjct: 299 -VKDRNGKTPLMVAVLNNHEELVQLLLDK-GADA-SVKNEFGKGVLEMARVFDRQSVVSL 355
Query: 1298 LLSR 1301
L R
Sbjct: 356 LEER 359
Score = 69.7 bits (163), Expect = 1e-10
Identities = 58/210 (27%), Positives = 98/210 (46%), Gaps = 7/210 (3%)
Query: 944 LVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAA 1003
LV L +VDV + G +AL +AA+ GY ++ L++N +N K +G+ +L LA
Sbjct: 152 LVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLAC 211
Query: 1004 MNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDE-LG 1062
G+ +VK+L R H A L T LH AA G V + +++ G +D D G
Sbjct: 212 YAGHLDVVKYL-RRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSG 270
Query: 1063 QKPI-HAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
P+ +A + V L + N V ++G T +A + ++++ L+ D+
Sbjct: 271 WTPLMRVSAVSGNQRVASLLIDAGAN-VNVKDRNGKTPLMVAVLNNHEELVQLLL--DKG 327
Query: 1122 GVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
S +N+ L++A VV +L
Sbjct: 328 ADASVKNEFGKGV-LEMARVFDRQSVVSLL 356
Score = 66.9 bits (156), Expect = 7e-10
Identities = 46/161 (28%), Positives = 83/161 (51%), Gaps = 3/161 (1%)
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
+N +N G L++AC+ GH+ +V L + A D+ G +ALH AA+ G+ V + +
Sbjct: 196 VNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWM 255
Query: 982 LTNKAFIN-SKARNGRTAL-HLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAAS 1039
+ + ++ +G T L ++A++G + LI D A ++V +TPL +A +
Sbjct: 256 IKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLI-DAGANVNVKDRNGKTPLMVAVLN 314
Query: 1040 GQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQL 1080
E+ +LLL+ GA+ +E G+ + A + VV L
Sbjct: 315 NHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSL 355
Score = 62.1 bits (144), Expect = 2e-08
Identities = 37/133 (27%), Positives = 70/133 (52%), Gaps = 1/133 (0%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G TAL +AA++ + +ILV G V+ NG+G+ L +A G +VKY A+
Sbjct: 170 GFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASW 229
Query: 158 AIADNEDRTPMHLAAENGHAAIIE-LLADKFKASIFERTKDGSTLMHIASLNGHADCAMM 216
D T +H AA+ GH ++IE ++ D + + + + LM +++++G+ A +
Sbjct: 230 QARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASL 289
Query: 217 LFKKGVYLHMPNK 229
L G +++ ++
Sbjct: 290 LIDAGANVNVKDR 302
Score = 59.3 bits (137), Expect = 1e-07
Identities = 37/122 (30%), Positives = 62/122 (50%), Gaps = 2/122 (1%)
Query: 1248 LHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLH 1307
LH A +E+++ +L V+ D N+ G+ L +A G+ +V +L+S ++ +
Sbjct: 140 LHRAVSVNDEDLLVRILQGGRVKVDVP-NKFGFTALMVAAQKGYTRLVKILVSNGTDV-N 197
Query: 1308 STDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCE 1367
+ GK L +A GH +V+ L GA A D G T LH AA GH +V++ + +
Sbjct: 198 LKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIK 257
Query: 1368 SG 1369
G
Sbjct: 258 DG 259
Score = 58.8 bits (136), Expect = 2e-07
Identities = 52/183 (28%), Positives = 86/183 (46%), Gaps = 10/183 (5%)
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIG 929
++VK L+ NG DV+L+ ++ C AG+ DV+ + H + +R L ++
Sbjct: 184 RLVKILVSNGTDVNLKNGSGKDSLMLAC-YAGHLDVVKYLRRH-GASWQARDLGGCTALH 241
Query: 930 WTPLLIACHRGHMQLVNTLLTNHARVDVFDV-EGRSAL-HLAAEHGYLQVCDALLTNKAF 987
W A GH ++ ++ + VDV D G + L ++A G +V L+ A
Sbjct: 242 W-----AADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGAN 296
Query: 988 INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKL 1047
+N K RNG+T L +A +N + LV+ L+ D A V + L +A + V L
Sbjct: 297 VNVKDRNGKTPLMVAVLNNHEELVQLLL-DKGADASVKNEFGKGVLEMARVFDRQSVVSL 355
Query: 1048 LLE 1050
L E
Sbjct: 356 LEE 358
Score = 58.4 bits (135), Expect = 3e-07
Identities = 29/90 (32%), Positives = 52/90 (57%)
Query: 1310 DRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESG 1369
++ G T L +A+ G+ ++V++L+ G ++N + +G L A AGHL+VVK L G
Sbjct: 167 NKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHG 226
Query: 1370 ASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
AS ++ C + +AA H V+E+++
Sbjct: 227 ASWQARDLGGCTALHWAADGGHCSVIEWMI 256
Score = 57.6 bits (133), Expect = 4e-07
Identities = 46/170 (27%), Positives = 81/170 (47%), Gaps = 5/170 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L++A + G +V+ L+S T LK +G +L LA +D+ + L +GA
Sbjct: 170 GFTALMVAAQKGYTRLVKILVSNGTDVNLK--NGSGKDSLMLACYAGHLDVVKYLRRHGA 227
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDR-TP-MHLAAENGHAAII 180
A + G T LH AA G ++++ + D TP M ++A +G+ +
Sbjct: 228 SWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVA 287
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
LL D A++ + ++G T + +A LN H + +L KG + N++
Sbjct: 288 SLLIDA-GANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEF 336
Score = 55.6 bits (128), Expect = 2e-06
Identities = 36/131 (27%), Positives = 60/131 (45%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ G S+ A GH+ ++ L + G S TALH A + +V+E ++
Sbjct: 199 KNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKD 258
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
G +V + TPL + + + A +L+ +GA N +G TP+ VA +
Sbjct: 259 GCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEE 318
Query: 779 TLVLLLEDGGD 789
+ LLL+ G D
Sbjct: 319 LVQLLLDKGAD 329
Score = 54.0 bits (124), Expect = 5e-06
Identities = 49/216 (22%), Positives = 94/216 (43%), Gaps = 2/216 (0%)
Query: 999 LHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDAT 1058
LH A L+ +++ +DV T L +AA G + K+L+ G +++
Sbjct: 140 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 199
Query: 1059 DELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKF 1118
+ G+ + A + +VV+ +L++H A G T H AA G VIE ++K
Sbjct: 200 NGSGKDSLMLACYAGHLDVVK-YLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIK- 257
Query: 1119 DRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHT 1178
D V + ++++A G+ V +L+ AGA+ ++R G T + +A + H
Sbjct: 258 DGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHE 317
Query: 1179 NVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETV 1214
++ ++ + G L +A + + V
Sbjct: 318 ELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVV 353
Score = 46.8 bits (106), Expect = 8e-04
Identities = 37/127 (29%), Positives = 52/127 (40%), Gaps = 2/127 (1%)
Query: 96 PAGDTALHLAARRRDVDM-ARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVR 154
P LH A D D+ RIL VD N G T L +AA +G LVK
Sbjct: 134 PISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNG 193
Query: 155 ANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCA 214
+ + + + + LA GH +++ L + AS R G T +H A+ GH
Sbjct: 194 TDVNLKNGSGKDSLMLACYAGHLDVVKYLR-RHGASWQARDLGGCTALHWAADGGHCSVI 252
Query: 215 MMLFKKG 221
+ K G
Sbjct: 253 EWMIKDG 259
Score = 44.8 bits (101), Expect = 0.003
Identities = 38/143 (26%), Positives = 66/143 (46%), Gaps = 9/143 (6%)
Query: 667 IHTAARYGHVGIINTLLQKGE-SVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+H A ++ +LQ G VDV +TAL +A + +V+ L+ G DV+++
Sbjct: 140 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 199
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
G +++ L +A D L + GA G T +H AA G+ + + +++
Sbjct: 200 NGSGKDS-LMLACYAGHLD-VVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIK 257
Query: 786 DGGDPLRKTKVCIYDVVTGETPL 808
DG +V + D +G TPL
Sbjct: 258 DG------CEVDVVDTGSGWTPL 274
Score = 39.9 bits (89), Expect = 0.096
Identities = 24/83 (28%), Positives = 41/83 (49%), Gaps = 1/83 (1%)
Query: 1317 LHIA-STHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSE 1375
LH A S + +V +L G +++ +K G+T L AA+ G+ +VK+L +G +
Sbjct: 140 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 199
Query: 1376 TNLNCAPIWFAASENHNDVLEYL 1398
+ A H DV++YL
Sbjct: 200 NGSGKDSLMLACYAGHLDVVKYL 222
Score = 39.9 bits (89), Expect = 0.096
Identities = 27/126 (21%), Positives = 58/126 (46%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L A + G+ S++ ++ + T + ++A + +A +L+D GA
Sbjct: 236 GCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGA 295
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
V+ + G+TPL +A E LV+ A+A++ + + + +A +++ L
Sbjct: 296 NVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSL 355
Query: 183 LADKFK 188
L ++ K
Sbjct: 356 LEERKK 361
>AK127855-1|BAC87163.1| 337|Homo sapiens protein ( Homo sapiens cDNA
FLJ45958 fis, clone PLACE7011559, highly similar to
Death-associated protein kinase 1 (EC 2.7.1.-). ).
Length = 337
Score = 97.1 bits (231), Expect = 6e-19
Identities = 76/238 (31%), Positives = 111/238 (46%), Gaps = 16/238 (6%)
Query: 1168 AVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKS 1227
A+H+AA +GH +V ++ S + K TPLH AA++G + L
Sbjct: 2 ALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGHYSVAKALC--------- 52
Query: 1228 EAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLAC 1287
EA V++ G TPL A+ G ++V L G +A +++G+ LHLA
Sbjct: 53 EAGCNVNIKN----REGETPLLTASARGYHDIVECLAEH-GADLNAC-DKDGHIALHLAV 106
Query: 1288 FGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGW 1347
M ++ LLS+ + DRHG T LH+A G+ +V L ++ ++K G
Sbjct: 107 RRCQMEVIKTLLSQGC-FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGR 165
Query: 1348 TPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDT 1405
TPLH AA G L+VV+ LC GAS ++ T A SE H V L DT
Sbjct: 166 TPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDT 223
Score = 95.1 bits (226), Expect = 2e-18
Identities = 70/220 (31%), Positives = 109/220 (49%), Gaps = 5/220 (2%)
Query: 965 ALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
ALH+AA +G+ V L + + N + + T LH AA +G+ + K L + +++
Sbjct: 2 ALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGHYSVAKALC-EAGCNVNI 60
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
+ +TPL A+A G ++ + L E GA+++A D+ G +H A + EV++ L Q
Sbjct: 61 KNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ 120
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
V + GNT H+A G++ ++ L + + IS NK TPL LAA G
Sbjct: 121 GC-FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDIS--NKYG-RTPLHLAANNGI 176
Query: 1145 ADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
DVVR L GAS G TA LA H +V ++
Sbjct: 177 LDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLL 216
Score = 90.2 bits (214), Expect = 7e-17
Identities = 66/227 (29%), Positives = 106/227 (46%), Gaps = 17/227 (7%)
Query: 1202 LHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVR 1261
LH+AA YG A+ + L S P + + TPLH AA++G+ +V +
Sbjct: 3 LHVAARYGHADVAQLLCSFGSN-------------PNIQDKEEETPLHCAAWHGHYSVAK 49
Query: 1262 LLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIAS 1321
L AG + N G PL A G+ IV L A+L ++ D+ G LH+A
Sbjct: 50 ALCE-AGCNVNI-KNREGETPLLTASARGYHDIVECLAEHGADL-NACDKDGHIALHLAV 106
Query: 1322 THGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCA 1381
++++ LL QG ++ D++G TPLH A K G++ +V LCE+ +
Sbjct: 107 RRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRT 166
Query: 1382 PIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNI 1428
P+ AA+ DV+ YL ++L D + +L S+ H ++
Sbjct: 167 PLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDL-ARSEQHEHV 212
Score = 89.8 bits (213), Expect = 9e-17
Identities = 62/210 (29%), Positives = 103/210 (49%), Gaps = 8/210 (3%)
Query: 871 VVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGW 930
V + L G++ ++Q + ET H A G+ V + + +N +N G
Sbjct: 14 VAQLLCSFGSNPNIQDKEE-ETPLHCAAWHGHYSVAKAL------CEAGCNVNIKNREGE 66
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPLL A RG+ +V L + A ++ D +G ALHLA ++V LL+ F++
Sbjct: 67 TPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDY 126
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
+ R+G T LH+A +G +V L + N +D+ +TPLHLAA +G ++V + L
Sbjct: 127 QDRHGNTPLHVACKDGNMPIVVALC-EANCNLDISNKYGRTPLHLAANNGILDVVRYLCL 185
Query: 1051 LGANIDATDELGQKPIHAAAQNNYSEVVQL 1080
+GA+++A G+ A + V L
Sbjct: 186 MGASVEALTTDGKTAEDLARSEQHEHVAGL 215
Score = 89.0 bits (211), Expect = 2e-16
Identities = 58/183 (31%), Positives = 86/183 (46%), Gaps = 2/183 (1%)
Query: 933 LLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKA 992
L +A GH + L + + ++ D E + LH AA HG+ V AL +N K
Sbjct: 3 LHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGHYSVAKALCEAGCNVNIKN 62
Query: 993 RNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELG 1052
R G T L A+ GY +V+ L +H A ++ LHLA Q+EV K LL G
Sbjct: 63 REGETPLLTASARGYHDIVECL-AEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQG 121
Query: 1053 ANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVI 1112
+D D G P+H A ++ +V + + NL + + K G T H+AA G + V+
Sbjct: 122 CFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDI-SNKYGRTPLHLAANNGILDVV 180
Query: 1113 EEL 1115
L
Sbjct: 181 RYL 183
Score = 86.6 bits (205), Expect = 8e-16
Identities = 54/181 (29%), Positives = 85/181 (46%), Gaps = 2/181 (1%)
Query: 923 NRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALL 982
N Q+ TPL A GH + L V++ + EG + L A+ GY + + L
Sbjct: 26 NIQDKEEETPLHCAAWHGHYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLA 85
Query: 983 TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQI 1042
+ A +N+ ++G ALHLA ++K L+ +D TPLH+A G +
Sbjct: 86 EHGADLNACDKDGHIALHLAVRRCQMEVIKTLL-SQGCFVDYQDRHGNTPLHVACKDGNM 144
Query: 1043 EVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHI 1102
+ L E N+D +++ G+ P+H AA N +VV+ +L V A T DG T +
Sbjct: 145 PIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVR-YLCLMGASVEALTTDGKTAEDL 203
Query: 1103 A 1103
A
Sbjct: 204 A 204
Score = 86.2 bits (204), Expect = 1e-15
Identities = 54/157 (34%), Positives = 76/157 (48%), Gaps = 3/157 (1%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+ G+ PLL A G +V L A+ L A G ALHLA RR +++ + L+
Sbjct: 63 REGETPLLTASARGYHDIVECL--AEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ 120
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
G VD + G TPLH+A +G+ P+V N I++ RTP+HLAA NG ++
Sbjct: 121 GCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVV 180
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMML 217
L AS+ T DG T +A H A +L
Sbjct: 181 RYLC-LMGASVEALTTDGKTAEDLARSEQHEHVAGLL 216
Score = 72.9 bits (171), Expect = 1e-11
Identities = 52/185 (28%), Positives = 90/185 (48%), Gaps = 4/185 (2%)
Query: 1033 LHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMAT 1092
LH+AA G +V +LL G+N + D+ + P+H AA + + V + + N V
Sbjct: 3 LHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGHYSVAKALCEAGCN-VNIK 61
Query: 1093 TKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
++G T A+ +G ++E L + ++A +K + L LA +V++ L+
Sbjct: 62 NREGETPLLTASARGYHDIVECLAEHGAD--LNACDK-DGHIALHLAVRRCQMEVIKTLL 118
Query: 1153 RAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAE 1212
G ++R G T +H+A + G+ ++ + N S K G TPLH+AA G +
Sbjct: 119 SQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILD 178
Query: 1213 TVREL 1217
VR L
Sbjct: 179 VVRYL 183
Score = 72.1 bits (169), Expect = 2e-11
Identities = 72/248 (29%), Positives = 103/248 (41%), Gaps = 34/248 (13%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
LH+AAR D A +L G+ PN ++ TP+H AA G+ + L E G + K
Sbjct: 3 LHVAARYGHAD-VAQLLCSFGSNPNIQDKEEETPLHCAAWHGHYSVAKALCEAGCNVNIK 61
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHY 853
+ GETPL A DIV L E D ++A D+DG ALH
Sbjct: 62 NR-------EGETPLLTASARGYHDIVECLAEHGAD----------LNACDKDGHIALHL 104
Query: 854 ACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHI 913
A + +V+K L+ G V Q RH + T H GN ++ +
Sbjct: 105 A---------VRRCQMEVIKTLLSQGCFVDYQDRHGN-TPLHVACKDGNMPIVVALCEAN 154
Query: 914 STADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHG 973
D+S N G TPL +A + G + +V L A V+ +G++A LA
Sbjct: 155 CNLDIS------NKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQ 208
Query: 974 YLQVCDAL 981
+ V L
Sbjct: 209 HEHVAGLL 216
Score = 71.3 bits (167), Expect = 3e-11
Identities = 70/234 (29%), Positives = 102/234 (43%), Gaps = 23/234 (9%)
Query: 1101 HIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTD 1160
H+AA G V + L F I + + TPL AA GH V + L AG +
Sbjct: 4 HVAARYGHADVAQLLCSFGSNPNIQDKE---EETPLHCAAWHGHYSVAKALCEAGCNVNI 60
Query: 1161 ENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSH 1220
+NR G T + A+ G+ ++++ + + K G LH+A Q E ++ LLS
Sbjct: 61 KNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ 120
Query: 1221 VPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGY 1280
G G TPLH+A +GN +V + L A D SN+ G
Sbjct: 121 --GCFVDYQD-----------RHGNTPLHVACKDGNMPIV-VALCEANCNLD-ISNKYGR 165
Query: 1281 NPLHLACFGGHMSIVG--LLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVL 1332
PLHLA G + +V L+ S E L +TD GKT +A + H + +L
Sbjct: 166 TPLHLAANNGILDVVRYLCLMGASVEAL-TTD--GKTAEDLARSEQHEHVAGLL 216
Score = 66.1 bits (154), Expect = 1e-09
Identities = 44/146 (30%), Positives = 71/146 (48%), Gaps = 7/146 (4%)
Query: 871 VVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGW 930
+V+CL E+GAD++ + H A H +V+ +++ D Q+ G
Sbjct: 80 IVECLAEHGADLNACDKDGH-IALHLAVRRCQMEVIKTLLSQGCFVDY------QDRHGN 132
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
TPL +AC G+M +V L + +D+ + GR+ LHLAA +G L V L A + +
Sbjct: 133 TPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEA 192
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIR 1016
+G+TA LA + H+ L R
Sbjct: 193 LTTDGKTAEDLARSEQHEHVAGLLAR 218
Score = 62.1 bits (144), Expect = 2e-08
Identities = 37/120 (30%), Positives = 64/120 (53%), Gaps = 4/120 (3%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ +G + TA+ G+ I+ L + G ++ D + ALH+AV C+ V++TLL
Sbjct: 61 KNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ 120
Query: 719 GADVHIRGGKQRETPLHIAARIPDGD-KCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
G V + + TPLH+A + DG+ + L ++ + + + G TP+H+AA G L
Sbjct: 121 GCFVDYQ-DRHGNTPLHVACK--DGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGIL 177
Score = 61.7 bits (143), Expect = 3e-08
Identities = 37/130 (28%), Positives = 63/130 (48%), Gaps = 1/130 (0%)
Query: 101 ALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIA 160
ALH+AAR D+A++L +G+ + + +TPLH AA G + K N I
Sbjct: 2 ALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGHYSVAKALCEAGCNVNIK 61
Query: 161 DNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+ E TP+ A+ G+ I+E LA+ A + KDG +H+A + L +
Sbjct: 62 NREGETPLLTASARGYHDIVECLAE-HGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ 120
Query: 221 GVYLHMPNKY 230
G ++ +++
Sbjct: 121 GCFVDYQDRH 130
Score = 60.1 bits (139), Expect = 8e-08
Identities = 48/159 (30%), Positives = 72/159 (45%), Gaps = 13/159 (8%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA +GH + L + G +V++ + T L A +VE L +GAD++
Sbjct: 36 LHCAAWHGHYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACD 95
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
K LH+A R + LL G + G TP+HVA K GN+ +V L E
Sbjct: 96 -KDGHIALHLAVRRCQMEVIKT-LLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEA 153
Query: 787 GGDPLRKTKVCIYDVVT--GETPLQMACRSCMPDIVRHL 823
C D+ G TPL +A + + D+VR+L
Sbjct: 154 N---------CNLDISNKYGRTPLHLAANNGILDVVRYL 183
Score = 57.2 bits (132), Expect = 6e-07
Identities = 46/162 (28%), Positives = 70/162 (43%), Gaps = 13/162 (8%)
Query: 666 SIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
++H AARYGH + L G + ++ + T LH A +V + L G +V+I+
Sbjct: 2 ALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGHYSVAKALCEAGCNVNIK 61
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
++ ETPL + A L + GA N +DG +H+A + + + LL
Sbjct: 62 -NREGETPL-LTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLS 119
Query: 786 DGGDPLRKTKVCIYDVVT--GETPLQMACRSCMPDIVRHLIE 825
G C D G TPL +AC+ IV L E
Sbjct: 120 QG---------CFVDYQDRHGNTPLHVACKDGNMPIVVALCE 152
Score = 54.4 bits (125), Expect = 4e-06
Identities = 35/132 (26%), Positives = 61/132 (46%), Gaps = 1/132 (0%)
Query: 99 DTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAA 158
+T LH AA +A+ L + G V+ N G+TPL A+A G +V+ A+
Sbjct: 33 ETPLHCAAWHGHYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLN 92
Query: 159 IADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLF 218
D + +HLA +I+ L + + + + G+T +H+A +G+ + L
Sbjct: 93 ACDKDGHIALHLAVRRCQMEVIKTLLSQ-GCFVDYQDRHGNTPLHVACKDGNMPIVVALC 151
Query: 219 KKGVYLHMPNKY 230
+ L + NKY
Sbjct: 152 EANCNLDISNKY 163
Score = 53.2 bits (122), Expect = 1e-05
Identities = 46/158 (29%), Positives = 68/158 (43%), Gaps = 19/158 (12%)
Query: 699 ALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPN 758
ALH+A V + L +G++ +I+ K+ ETPLH AA A L ++G N
Sbjct: 2 ALHVAARYGHADVAQLLCSFGSNPNIQD-KEEETPLHCAAW-HGHYSVAKALCEAGCNVN 59
Query: 759 KATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPD 818
+G TP+ A+ G + L E G D C D G L +A R C +
Sbjct: 60 IKNREGETPLLTASARGYHDIVECLAEHGAD----LNACDKD---GHIALHLAVRRCQME 112
Query: 819 IVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACK 856
+++ L+ F+D D G + LH ACK
Sbjct: 113 VIKTLLS----------QGCFVDYQDRHGNTPLHVACK 140
Score = 49.2 bits (112), Expect = 2e-04
Identities = 34/122 (27%), Positives = 57/122 (46%), Gaps = 2/122 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G + L LAV +++ LLS + G+T LH+A + ++ + L +
Sbjct: 98 GHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRH--GNTPLHVACKDGNMPIVVALCEANC 155
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+D +N G+TPLH+AA G +V+Y + A+ + +T LA H + L
Sbjct: 156 NLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGL 215
Query: 183 LA 184
LA
Sbjct: 216 LA 217
>BC052988-1|AAH52988.1| 980|Homo sapiens retinoic acid induced 14
protein.
Length = 980
Score = 95.9 bits (228), Expect = 1e-18
Identities = 64/230 (27%), Positives = 106/230 (46%), Gaps = 4/230 (1%)
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A NG A V L+ A + +T HLAAA G +E ++++ G ++ A D
Sbjct: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 85
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
G +H AA+N++ E ++ LQ + G T H AA QG ++ ++ L +
Sbjct: 86 GHSALHLAAKNSHHECIRKLLQSKCP-AESVDSSGKTALHYAAAQGCLQAVQILC--EHK 142
Query: 1122 GVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVL 1181
I+ ++ L+ + PL LA + GH+++ L+ GA N++G TA+ LA E G +N +
Sbjct: 143 SPINLKD-LDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 201
Query: 1182 DVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT 1231
+ + LG LH + A LLS + + PT
Sbjct: 202 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPT 251
Score = 93.5 bits (222), Expect = 7e-18
Identities = 65/223 (29%), Positives = 107/223 (47%), Gaps = 11/223 (4%)
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHE--TAFHYCAIAGNNDVMTEMIAHISTADVSRA 921
+ D + V L+ G + T+H+ E TAFH A G+ + + MI H DV+
Sbjct: 27 VENGDAEKVASLL--GKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITH--GVDVT-- 80
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
Q++ G + L +A H + + LL + + D G++ALH AA G LQ L
Sbjct: 81 --AQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQIL 138
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
+K+ IN K +G L LA NG++ + FL+ DH A ++ +T L LA G
Sbjct: 139 CEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLL-DHGADVNSRNKSGRTALMLACEIGS 197
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
+ L++ GA+++ D LG +H + + + + L L +
Sbjct: 198 SNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
Score = 88.6 bits (210), Expect = 2e-16
Identities = 73/235 (31%), Positives = 104/235 (44%), Gaps = 16/235 (6%)
Query: 1131 NDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTL 1190
ND LQ G V +L + GAS T + G TA HLAA GH L VM +
Sbjct: 19 NDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVD 78
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHL 1250
+ G + LH+AA E +R+LL +S+ P SG T LH
Sbjct: 79 VTAQDTTGHSALHLAAKNSHHECIRKLL-------QSKCPAESV------DSSGKTALHY 125
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AA G V++L + +G PL LA GH I LL A+ ++S +
Sbjct: 126 AAAQGCLQAVQILCEHK--SPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGAD-VNSRN 182
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
+ G+T L +A G VE L+ +GA++N D G+ LH + + + + LL
Sbjct: 183 KSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLL 237
Score = 88.6 bits (210), Expect = 2e-16
Identities = 50/165 (30%), Positives = 89/165 (53%), Gaps = 1/165 (0%)
Query: 924 RQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLT 983
+ +S G T +A +GH++ + ++T+ V D G SALHLAA++ + + LL
Sbjct: 48 KHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQ 107
Query: 984 NKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIE 1043
+K S +G+TALH AA G V+ L +H + I++ L PL LA +G E
Sbjct: 108 SKCPAESVDSSGKTALHYAAAQGCLQAVQILC-EHKSPINLKDLDGNIPLLLAVQNGHSE 166
Query: 1044 VCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNL 1088
+C LL+ GA++++ ++ G+ + A + S V+ +++ +L
Sbjct: 167 ICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADL 211
Score = 79.4 bits (187), Expect = 1e-13
Identities = 58/192 (30%), Positives = 85/192 (44%), Gaps = 6/192 (3%)
Query: 1244 GLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSA 1303
G T HLAA G+ +R+++ GV A + G++ LHLA H + LL
Sbjct: 53 GKTAFHLAAAKGHVECLRVMITH-GVDV-TAQDTTGHSALHLAAKNSHHECIRKLLQSKC 110
Query: 1304 ELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVK 1363
S D GKT LH A+ G Q V++L + IN D +G PL A + GH +
Sbjct: 111 PA-ESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICH 169
Query: 1364 LLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSK 1423
L + GA S + A ++ +E L+ K D +L+D YN + SK
Sbjct: 170 FLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADL-NLVDS--LGYNALHYSK 226
Query: 1424 NHNNIPIEEFVL 1435
N I+ +L
Sbjct: 227 LSENAGIQSLLL 238
Score = 77.0 bits (181), Expect = 7e-13
Identities = 48/163 (29%), Positives = 79/163 (48%), Gaps = 2/163 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
LL AVE G+ V LL + A K + G TA HLAA + V+ R+++ +G V A
Sbjct: 23 LLQAVENGDAEKVASLLGKKGASATKHDSE-GKTAFHLAAAKGHVECLRVMITHGVDVTA 81
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G + LH+AA ++ + A D+ +T +H AA G +++L +
Sbjct: 82 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCE- 140
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
K+ I + DG+ + +A NGH++ L G ++ NK
Sbjct: 141 HKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK 183
Score = 70.9 bits (166), Expect = 4e-11
Identities = 48/164 (29%), Positives = 79/164 (48%), Gaps = 3/164 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
GK LA G+ +R +++ + TT G +ALHLAA+ + R L+
Sbjct: 53 GKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT--GHSALHLAAKNSHHECIRKLLQSKC 110
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
++ + +G+T LH AAA+G V+ ++ + D + P+ LA +NGH+ I
Sbjct: 111 PAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHF 170
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHM 226
L D A + R K G T + +A G ++ L KKG L++
Sbjct: 171 LLDH-GADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNL 213
Score = 68.1 bits (159), Expect = 3e-10
Identities = 56/204 (27%), Positives = 93/204 (45%), Gaps = 16/204 (7%)
Query: 1198 GLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNE 1257
G T H+AA G E +R +++H GV + +G + LHLAA N +
Sbjct: 53 GKTAFHLAAAKGHVECLRVMITH-----------GVDVTAQ--DTTGHSALHLAAKNSHH 99
Query: 1258 NVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGL 1317
+R LL S A++ + +G LH A G + V +L + + + D G L
Sbjct: 100 ECIRKLLQSK-CPAESVDS-SGKTALHYAAAQGCLQAVQILCEHKSPI-NLKDLDGNIPL 156
Query: 1318 HIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETN 1377
+A +GH ++ LL GA++N+ +K+G T L A + G N V+ L + GA +
Sbjct: 157 LLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDS 216
Query: 1378 LNCAPIWFAASENHNDVLEYLLHK 1401
L + ++ + + LL K
Sbjct: 217 LGYNALHYSKLSENAGIQSLLLSK 240
Score = 58.4 bits (135), Expect = 3e-07
Identities = 60/226 (26%), Positives = 101/226 (44%), Gaps = 33/226 (14%)
Query: 742 DGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDV 801
D +K A +L K GA K +G T H+AA G++ L +++ G D V D
Sbjct: 31 DAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVD------VTAQD- 83
Query: 802 VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEE 861
TG + L +A ++ + +R L++ S ++VD G +ALHYA
Sbjct: 84 TTGHSALHLAAKNSHHECIRKLLQ----------SKCPAESVDSSGKTALHYAA------ 127
Query: 862 VKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRA 921
Q V+ L E+ + ++L+ + G++++ ++ H ADV
Sbjct: 128 ---AQGCLQAVQILCEHKSPINLKDLDGN-IPLLLAVQNGHSEICHFLLDH--GADV--- 178
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALH 967
N +N G T L++AC G V L+ A +++ D G +ALH
Sbjct: 179 -NSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALH 223
Score = 57.2 bits (132), Expect = 6e-07
Identities = 40/157 (25%), Positives = 71/157 (45%), Gaps = 3/157 (1%)
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP 1349
G V LL + D GKT H+A+ GH + + V++ G ++ A D G +
Sbjct: 30 GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSA 89
Query: 1350 LHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLM 1409
LH AAK H ++ L +S +S + + +AA++ ++ L EH + +
Sbjct: 90 LHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILC--EHKSPINL 147
Query: 1410 DDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAK 1446
D L++ +N ++ I F+L A V++ K
Sbjct: 148 KDLDGNIPLLLAVQNGHS-EICHFLLDHGADVNSRNK 183
Score = 56.0 bits (129), Expect = 1e-06
Identities = 52/190 (27%), Positives = 84/190 (44%), Gaps = 16/190 (8%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+ A D G SALH A K + E ++ L+++ + +TA HY A
Sbjct: 79 VTAQDTTGHSALHLAAKNSHHEC---------IRKLLQSKCPAE-SVDSSGKTALHYAAA 128
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
G + + H S +N ++ G PLL+A GH ++ + LL + A V+ +
Sbjct: 129 QGCLQAVQILCEHKSP------INLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRN 182
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
GR+AL LA E G +AL+ A +N G ALH + ++ A + L+ +
Sbjct: 183 KSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKIS 242
Query: 1020 AMIDVLTLKK 1029
D+ T K
Sbjct: 243 QDADLKTPTK 252
Score = 54.0 bits (124), Expect = 5e-06
Identities = 56/237 (23%), Positives = 105/237 (44%), Gaps = 29/237 (12%)
Query: 678 IINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIA 737
+ + L +KG S ++ TA H+A + ++ +G DV + + LH+A
Sbjct: 35 VASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ-DTTGHSALHLA 93
Query: 738 ARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVC 797
A+ +C LL+S G T +H AA G L + +L E K+ +
Sbjct: 94 AK-NSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCE------HKSPIN 146
Query: 798 IYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKV 857
+ D + G PL +A ++ +I F+ DH + +++ ++ G +AL AC++
Sbjct: 147 LKD-LDGNIPLLLAVQNGHSEI----CHFLLDHGAD------VNSRNKSGRTALMLACEI 195
Query: 858 TKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHIS 914
V+ LI+ GAD++L + A HY ++ N + + +++ IS
Sbjct: 196 ---------GSSNAVEALIKKGADLNLVDSLGY-NALHYSKLSENAGIQSLLLSKIS 242
Score = 51.2 bits (117), Expect = 4e-05
Identities = 57/196 (29%), Positives = 85/196 (43%), Gaps = 25/196 (12%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTND--NYTALHIAVESCKPAVVETLLGYG 719
+G + H AA GHV + ++ G VDVT D ++ALH+A ++ + LL
Sbjct: 52 EGKTAFHLAAAKGHVECLRVMITHG--VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSK 109
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP-NKATEDGMTPVHVAAKFGNLA 778
+T LH AA G A+ +L P N DG P+ +A + G+
Sbjct: 110 CPAE-SVDSSGKTALHYAA--AQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSE 166
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
LL+ G D + K +G T L +AC + V LI+ KG A
Sbjct: 167 ICHFLLDHGADVNSRNK-------SGRTALMLACEIGSSNAVEALIK-----KG-----A 209
Query: 839 FIDAVDEDGASALHYA 854
++ VD G +ALHY+
Sbjct: 210 DLNLVDSLGYNALHYS 225
Score = 48.4 bits (110), Expect = 3e-04
Identities = 38/158 (24%), Positives = 70/158 (44%), Gaps = 3/158 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L LA + + +R+LL ++ + + +G TALH AA + + +IL ++ +
Sbjct: 86 GHSALHLAAKNSHHECIRKLLQSKCPAE--SVDSSGKTALHYAAAQGCLQAVQILCEHKS 143
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
++ + G PL +A G + + A+ + RT + LA E G + +E
Sbjct: 144 PINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEA 203
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L K A + G +H + L+ +A +L K
Sbjct: 204 LIKK-GADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
Score = 35.9 bits (79), Expect = 1.6
Identities = 22/66 (33%), Positives = 31/66 (46%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K DG + A + GH I + LL G V+ TAL +A E VE L+
Sbjct: 148 KDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKK 207
Query: 719 GADVHI 724
GAD+++
Sbjct: 208 GADLNL 213
>AY354204-1|AAQ63889.2| 972|Homo sapiens retinoic acid induced 14
isoform protein.
Length = 972
Score = 95.9 bits (228), Expect = 1e-18
Identities = 64/230 (27%), Positives = 106/230 (46%), Gaps = 4/230 (1%)
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A NG A V L+ A + +T HLAAA G +E ++++ G ++ A D
Sbjct: 18 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 77
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
G +H AA+N++ E ++ LQ + G T H AA QG ++ ++ L +
Sbjct: 78 GHSALHLAAKNSHHECIRKLLQSKCP-AESVDSSGKTALHYAAAQGCLQAVQILC--EHK 134
Query: 1122 GVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVL 1181
I+ ++ L+ + PL LA + GH+++ L+ GA N++G TA+ LA E G +N +
Sbjct: 135 SPINLKD-LDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 193
Query: 1182 DVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT 1231
+ + LG LH + A LLS + + PT
Sbjct: 194 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPT 243
Score = 93.5 bits (222), Expect = 7e-18
Identities = 65/223 (29%), Positives = 107/223 (47%), Gaps = 11/223 (4%)
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHE--TAFHYCAIAGNNDVMTEMIAHISTADVSRA 921
+ D + V L+ G + T+H+ E TAFH A G+ + + MI H DV+
Sbjct: 19 VENGDAEKVASLL--GKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITH--GVDVT-- 72
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
Q++ G + L +A H + + LL + + D G++ALH AA G LQ L
Sbjct: 73 --AQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQIL 130
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
+K+ IN K +G L LA NG++ + FL+ DH A ++ +T L LA G
Sbjct: 131 CEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLL-DHGADVNSRNKSGRTALMLACEIGS 189
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
+ L++ GA+++ D LG +H + + + + L L +
Sbjct: 190 SNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 232
Score = 88.6 bits (210), Expect = 2e-16
Identities = 73/235 (31%), Positives = 104/235 (44%), Gaps = 16/235 (6%)
Query: 1131 NDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTL 1190
ND LQ G V +L + GAS T + G TA HLAA GH L VM +
Sbjct: 11 NDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVD 70
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHL 1250
+ G + LH+AA E +R+LL +S+ P SG T LH
Sbjct: 71 VTAQDTTGHSALHLAAKNSHHECIRKLL-------QSKCPAESV------DSSGKTALHY 117
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AA G V++L + +G PL LA GH I LL A+ ++S +
Sbjct: 118 AAAQGCLQAVQILCEHK--SPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGAD-VNSRN 174
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
+ G+T L +A G VE L+ +GA++N D G+ LH + + + + LL
Sbjct: 175 KSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLL 229
Score = 88.6 bits (210), Expect = 2e-16
Identities = 50/165 (30%), Positives = 89/165 (53%), Gaps = 1/165 (0%)
Query: 924 RQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLT 983
+ +S G T +A +GH++ + ++T+ V D G SALHLAA++ + + LL
Sbjct: 40 KHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQ 99
Query: 984 NKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIE 1043
+K S +G+TALH AA G V+ L +H + I++ L PL LA +G E
Sbjct: 100 SKCPAESVDSSGKTALHYAAAQGCLQAVQILC-EHKSPINLKDLDGNIPLLLAVQNGHSE 158
Query: 1044 VCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNL 1088
+C LL+ GA++++ ++ G+ + A + S V+ +++ +L
Sbjct: 159 ICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADL 203
Score = 79.4 bits (187), Expect = 1e-13
Identities = 58/192 (30%), Positives = 85/192 (44%), Gaps = 6/192 (3%)
Query: 1244 GLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSA 1303
G T HLAA G+ +R+++ GV A + G++ LHLA H + LL
Sbjct: 45 GKTAFHLAAAKGHVECLRVMITH-GVDV-TAQDTTGHSALHLAAKNSHHECIRKLLQSKC 102
Query: 1304 ELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVK 1363
S D GKT LH A+ G Q V++L + IN D +G PL A + GH +
Sbjct: 103 PA-ESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICH 161
Query: 1364 LLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSK 1423
L + GA S + A ++ +E L+ K D +L+D YN + SK
Sbjct: 162 FLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADL-NLVDS--LGYNALHYSK 218
Query: 1424 NHNNIPIEEFVL 1435
N I+ +L
Sbjct: 219 LSENAGIQSLLL 230
Score = 77.0 bits (181), Expect = 7e-13
Identities = 48/163 (29%), Positives = 79/163 (48%), Gaps = 2/163 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
LL AVE G+ V LL + A K + G TA HLAA + V+ R+++ +G V A
Sbjct: 15 LLQAVENGDAEKVASLLGKKGASATKHDSE-GKTAFHLAAAKGHVECLRVMITHGVDVTA 73
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G + LH+AA ++ + A D+ +T +H AA G +++L +
Sbjct: 74 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCE- 132
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
K+ I + DG+ + +A NGH++ L G ++ NK
Sbjct: 133 HKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK 175
Score = 70.9 bits (166), Expect = 4e-11
Identities = 48/164 (29%), Positives = 79/164 (48%), Gaps = 3/164 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
GK LA G+ +R +++ + TT G +ALHLAA+ + R L+
Sbjct: 45 GKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT--GHSALHLAAKNSHHECIRKLLQSKC 102
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
++ + +G+T LH AAA+G V+ ++ + D + P+ LA +NGH+ I
Sbjct: 103 PAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHF 162
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHM 226
L D A + R K G T + +A G ++ L KKG L++
Sbjct: 163 LLDH-GADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNL 205
Score = 68.1 bits (159), Expect = 3e-10
Identities = 56/204 (27%), Positives = 93/204 (45%), Gaps = 16/204 (7%)
Query: 1198 GLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNE 1257
G T H+AA G E +R +++H GV + +G + LHLAA N +
Sbjct: 45 GKTAFHLAAAKGHVECLRVMITH-----------GVDVTAQ--DTTGHSALHLAAKNSHH 91
Query: 1258 NVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGL 1317
+R LL S A++ + +G LH A G + V +L + + + D G L
Sbjct: 92 ECIRKLLQSK-CPAESVDS-SGKTALHYAAAQGCLQAVQILCEHKSPI-NLKDLDGNIPL 148
Query: 1318 HIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETN 1377
+A +GH ++ LL GA++N+ +K+G T L A + G N V+ L + GA +
Sbjct: 149 LLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDS 208
Query: 1378 LNCAPIWFAASENHNDVLEYLLHK 1401
L + ++ + + LL K
Sbjct: 209 LGYNALHYSKLSENAGIQSLLLSK 232
Score = 58.4 bits (135), Expect = 3e-07
Identities = 46/177 (25%), Positives = 79/177 (44%), Gaps = 5/177 (2%)
Query: 1272 DAASNENGYNPLHL--ACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMV 1329
+A +NE N L A G V LL + D GKT H+A+ GH + +
Sbjct: 2 EAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 61
Query: 1330 EVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASE 1389
V++ G ++ A D G + LH AAK H ++ L +S +S + + +AA++
Sbjct: 62 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 121
Query: 1390 NHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAK 1446
++ L EH + + D L++ +N ++ I F+L A V++ K
Sbjct: 122 GCLQAVQILC--EHKSPINLKDLDGNIPLLLAVQNGHS-EICHFLLDHGADVNSRNK 175
Score = 58.4 bits (135), Expect = 3e-07
Identities = 60/226 (26%), Positives = 101/226 (44%), Gaps = 33/226 (14%)
Query: 742 DGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDV 801
D +K A +L K GA K +G T H+AA G++ L +++ G D V D
Sbjct: 23 DAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVD------VTAQD- 75
Query: 802 VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEE 861
TG + L +A ++ + +R L++ S ++VD G +ALHYA
Sbjct: 76 TTGHSALHLAAKNSHHECIRKLLQ----------SKCPAESVDSSGKTALHYAA------ 119
Query: 862 VKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRA 921
Q V+ L E+ + ++L+ + G++++ ++ H ADV
Sbjct: 120 ---AQGCLQAVQILCEHKSPINLKDLDGN-IPLLLAVQNGHSEICHFLLDH--GADV--- 170
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALH 967
N +N G T L++AC G V L+ A +++ D G +ALH
Sbjct: 171 -NSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALH 215
Score = 56.0 bits (129), Expect = 1e-06
Identities = 52/190 (27%), Positives = 84/190 (44%), Gaps = 16/190 (8%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+ A D G SALH A K + E ++ L+++ + +TA HY A
Sbjct: 71 VTAQDTTGHSALHLAAKNSHHEC---------IRKLLQSKCPAE-SVDSSGKTALHYAAA 120
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
G + + H S +N ++ G PLL+A GH ++ + LL + A V+ +
Sbjct: 121 QGCLQAVQILCEHKSP------INLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRN 174
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
GR+AL LA E G +AL+ A +N G ALH + ++ A + L+ +
Sbjct: 175 KSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKIS 234
Query: 1020 AMIDVLTLKK 1029
D+ T K
Sbjct: 235 QDADLKTPTK 244
Score = 54.0 bits (124), Expect = 5e-06
Identities = 56/237 (23%), Positives = 105/237 (44%), Gaps = 29/237 (12%)
Query: 678 IINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIA 737
+ + L +KG S ++ TA H+A + ++ +G DV + + LH+A
Sbjct: 27 VASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ-DTTGHSALHLA 85
Query: 738 ARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVC 797
A+ +C LL+S G T +H AA G L + +L E K+ +
Sbjct: 86 AK-NSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCE------HKSPIN 138
Query: 798 IYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKV 857
+ D + G PL +A ++ +I F+ DH + +++ ++ G +AL AC++
Sbjct: 139 LKD-LDGNIPLLLAVQNGHSEI----CHFLLDHGAD------VNSRNKSGRTALMLACEI 187
Query: 858 TKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHIS 914
V+ LI+ GAD++L + A HY ++ N + + +++ IS
Sbjct: 188 ---------GSSNAVEALIKKGADLNLVDSLGY-NALHYSKLSENAGIQSLLLSKIS 234
Score = 51.2 bits (117), Expect = 4e-05
Identities = 57/196 (29%), Positives = 85/196 (43%), Gaps = 25/196 (12%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTND--NYTALHIAVESCKPAVVETLLGYG 719
+G + H AA GHV + ++ G VDVT D ++ALH+A ++ + LL
Sbjct: 44 EGKTAFHLAAAKGHVECLRVMITHG--VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSK 101
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP-NKATEDGMTPVHVAAKFGNLA 778
+T LH AA G A+ +L P N DG P+ +A + G+
Sbjct: 102 CPAE-SVDSSGKTALHYAA--AQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSE 158
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
LL+ G D + K +G T L +AC + V LI+ KG A
Sbjct: 159 ICHFLLDHGADVNSRNK-------SGRTALMLACEIGSSNAVEALIK-----KG-----A 201
Query: 839 FIDAVDEDGASALHYA 854
++ VD G +ALHY+
Sbjct: 202 DLNLVDSLGYNALHYS 217
Score = 48.4 bits (110), Expect = 3e-04
Identities = 38/158 (24%), Positives = 70/158 (44%), Gaps = 3/158 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L LA + + +R+LL ++ + + +G TALH AA + + +IL ++ +
Sbjct: 78 GHSALHLAAKNSHHECIRKLLQSKCPAE--SVDSSGKTALHYAAAQGCLQAVQILCEHKS 135
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
++ + G PL +A G + + A+ + RT + LA E G + +E
Sbjct: 136 PINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEA 195
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L K A + G +H + L+ +A +L K
Sbjct: 196 LIKK-GADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 232
Score = 35.9 bits (79), Expect = 1.6
Identities = 22/66 (33%), Positives = 31/66 (46%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K DG + A + GH I + LL G V+ TAL +A E VE L+
Sbjct: 140 KDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKK 199
Query: 719 GADVHI 724
GAD+++
Sbjct: 200 GADLNL 205
>AY317139-1|AAP84319.1| 983|Homo sapiens RAI14 isoform protein.
Length = 983
Score = 95.9 bits (228), Expect = 1e-18
Identities = 64/230 (27%), Positives = 106/230 (46%), Gaps = 4/230 (1%)
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A NG A V L+ A + +T HLAAA G +E ++++ G ++ A D
Sbjct: 29 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 88
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
G +H AA+N++ E ++ LQ + G T H AA QG ++ ++ L +
Sbjct: 89 GHSALHLAAKNSHHECIRKLLQSKCP-AESVDSSGKTALHYAAAQGCLQAVQILC--EHK 145
Query: 1122 GVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVL 1181
I+ ++ L+ + PL LA + GH+++ L+ GA N++G TA+ LA E G +N +
Sbjct: 146 SPINLKD-LDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 204
Query: 1182 DVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT 1231
+ + LG LH + A LLS + + PT
Sbjct: 205 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPT 254
Score = 93.5 bits (222), Expect = 7e-18
Identities = 65/223 (29%), Positives = 107/223 (47%), Gaps = 11/223 (4%)
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHE--TAFHYCAIAGNNDVMTEMIAHISTADVSRA 921
+ D + V L+ G + T+H+ E TAFH A G+ + + MI H DV+
Sbjct: 30 VENGDAEKVASLL--GKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITH--GVDVT-- 83
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
Q++ G + L +A H + + LL + + D G++ALH AA G LQ L
Sbjct: 84 --AQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQIL 141
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
+K+ IN K +G L LA NG++ + FL+ DH A ++ +T L LA G
Sbjct: 142 CEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLL-DHGADVNSRNKSGRTALMLACEIGS 200
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
+ L++ GA+++ D LG +H + + + + L L +
Sbjct: 201 SNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 243
Score = 88.6 bits (210), Expect = 2e-16
Identities = 73/235 (31%), Positives = 104/235 (44%), Gaps = 16/235 (6%)
Query: 1131 NDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTL 1190
ND LQ G V +L + GAS T + G TA HLAA GH L VM +
Sbjct: 22 NDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVD 81
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHL 1250
+ G + LH+AA E +R+LL +S+ P SG T LH
Sbjct: 82 VTAQDTTGHSALHLAAKNSHHECIRKLL-------QSKCPAESV------DSSGKTALHY 128
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AA G V++L + +G PL LA GH I LL A+ ++S +
Sbjct: 129 AAAQGCLQAVQILCEHK--SPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGAD-VNSRN 185
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
+ G+T L +A G VE L+ +GA++N D G+ LH + + + + LL
Sbjct: 186 KSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLL 240
Score = 88.6 bits (210), Expect = 2e-16
Identities = 50/165 (30%), Positives = 89/165 (53%), Gaps = 1/165 (0%)
Query: 924 RQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLT 983
+ +S G T +A +GH++ + ++T+ V D G SALHLAA++ + + LL
Sbjct: 51 KHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQ 110
Query: 984 NKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIE 1043
+K S +G+TALH AA G V+ L +H + I++ L PL LA +G E
Sbjct: 111 SKCPAESVDSSGKTALHYAAAQGCLQAVQILC-EHKSPINLKDLDGNIPLLLAVQNGHSE 169
Query: 1044 VCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNL 1088
+C LL+ GA++++ ++ G+ + A + S V+ +++ +L
Sbjct: 170 ICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADL 214
Score = 79.4 bits (187), Expect = 1e-13
Identities = 58/192 (30%), Positives = 85/192 (44%), Gaps = 6/192 (3%)
Query: 1244 GLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSA 1303
G T HLAA G+ +R+++ GV A + G++ LHLA H + LL
Sbjct: 56 GKTAFHLAAAKGHVECLRVMITH-GVDV-TAQDTTGHSALHLAAKNSHHECIRKLLQSKC 113
Query: 1304 ELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVK 1363
S D GKT LH A+ G Q V++L + IN D +G PL A + GH +
Sbjct: 114 PA-ESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICH 172
Query: 1364 LLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSK 1423
L + GA S + A ++ +E L+ K D +L+D YN + SK
Sbjct: 173 FLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADL-NLVDS--LGYNALHYSK 229
Query: 1424 NHNNIPIEEFVL 1435
N I+ +L
Sbjct: 230 LSENAGIQSLLL 241
Score = 77.0 bits (181), Expect = 7e-13
Identities = 48/163 (29%), Positives = 79/163 (48%), Gaps = 2/163 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
LL AVE G+ V LL + A K + G TA HLAA + V+ R+++ +G V A
Sbjct: 26 LLQAVENGDAEKVASLLGKKGASATKHDSE-GKTAFHLAAAKGHVECLRVMITHGVDVTA 84
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G + LH+AA ++ + A D+ +T +H AA G +++L +
Sbjct: 85 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCE- 143
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
K+ I + DG+ + +A NGH++ L G ++ NK
Sbjct: 144 HKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK 186
Score = 70.9 bits (166), Expect = 4e-11
Identities = 48/164 (29%), Positives = 79/164 (48%), Gaps = 3/164 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
GK LA G+ +R +++ + TT G +ALHLAA+ + R L+
Sbjct: 56 GKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT--GHSALHLAAKNSHHECIRKLLQSKC 113
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
++ + +G+T LH AAA+G V+ ++ + D + P+ LA +NGH+ I
Sbjct: 114 PAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHF 173
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHM 226
L D A + R K G T + +A G ++ L KKG L++
Sbjct: 174 LLDH-GADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNL 216
Score = 68.1 bits (159), Expect = 3e-10
Identities = 56/204 (27%), Positives = 93/204 (45%), Gaps = 16/204 (7%)
Query: 1198 GLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNE 1257
G T H+AA G E +R +++H GV + +G + LHLAA N +
Sbjct: 56 GKTAFHLAAAKGHVECLRVMITH-----------GVDVTAQ--DTTGHSALHLAAKNSHH 102
Query: 1258 NVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGL 1317
+R LL S A++ + +G LH A G + V +L + + + D G L
Sbjct: 103 ECIRKLLQSK-CPAESVDS-SGKTALHYAAAQGCLQAVQILCEHKSPI-NLKDLDGNIPL 159
Query: 1318 HIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETN 1377
+A +GH ++ LL GA++N+ +K+G T L A + G N V+ L + GA +
Sbjct: 160 LLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDS 219
Query: 1378 LNCAPIWFAASENHNDVLEYLLHK 1401
L + ++ + + LL K
Sbjct: 220 LGYNALHYSKLSENAGIQSLLLSK 243
Score = 58.4 bits (135), Expect = 3e-07
Identities = 60/226 (26%), Positives = 101/226 (44%), Gaps = 33/226 (14%)
Query: 742 DGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDV 801
D +K A +L K GA K +G T H+AA G++ L +++ G D V D
Sbjct: 34 DAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVD------VTAQD- 86
Query: 802 VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEE 861
TG + L +A ++ + +R L++ S ++VD G +ALHYA
Sbjct: 87 TTGHSALHLAAKNSHHECIRKLLQ----------SKCPAESVDSSGKTALHYAA------ 130
Query: 862 VKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRA 921
Q V+ L E+ + ++L+ + G++++ ++ H ADV
Sbjct: 131 ---AQGCLQAVQILCEHKSPINLKDLDGN-IPLLLAVQNGHSEICHFLLDH--GADV--- 181
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALH 967
N +N G T L++AC G V L+ A +++ D G +ALH
Sbjct: 182 -NSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALH 226
Score = 57.2 bits (132), Expect = 6e-07
Identities = 40/157 (25%), Positives = 71/157 (45%), Gaps = 3/157 (1%)
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP 1349
G V LL + D GKT H+A+ GH + + V++ G ++ A D G +
Sbjct: 33 GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSA 92
Query: 1350 LHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLM 1409
LH AAK H ++ L +S +S + + +AA++ ++ L EH + +
Sbjct: 93 LHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILC--EHKSPINL 150
Query: 1410 DDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAK 1446
D L++ +N ++ I F+L A V++ K
Sbjct: 151 KDLDGNIPLLLAVQNGHS-EICHFLLDHGADVNSRNK 186
Score = 56.0 bits (129), Expect = 1e-06
Identities = 52/190 (27%), Positives = 84/190 (44%), Gaps = 16/190 (8%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+ A D G SALH A K + E ++ L+++ + +TA HY A
Sbjct: 82 VTAQDTTGHSALHLAAKNSHHEC---------IRKLLQSKCPAE-SVDSSGKTALHYAAA 131
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
G + + H S +N ++ G PLL+A GH ++ + LL + A V+ +
Sbjct: 132 QGCLQAVQILCEHKSP------INLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRN 185
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
GR+AL LA E G +AL+ A +N G ALH + ++ A + L+ +
Sbjct: 186 KSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKIS 245
Query: 1020 AMIDVLTLKK 1029
D+ T K
Sbjct: 246 QDADLKTPTK 255
Score = 54.0 bits (124), Expect = 5e-06
Identities = 56/237 (23%), Positives = 105/237 (44%), Gaps = 29/237 (12%)
Query: 678 IINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIA 737
+ + L +KG S ++ TA H+A + ++ +G DV + + LH+A
Sbjct: 38 VASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ-DTTGHSALHLA 96
Query: 738 ARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVC 797
A+ +C LL+S G T +H AA G L + +L E K+ +
Sbjct: 97 AK-NSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCE------HKSPIN 149
Query: 798 IYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKV 857
+ D + G PL +A ++ +I F+ DH + +++ ++ G +AL AC++
Sbjct: 150 LKD-LDGNIPLLLAVQNGHSEI----CHFLLDHGAD------VNSRNKSGRTALMLACEI 198
Query: 858 TKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHIS 914
V+ LI+ GAD++L + A HY ++ N + + +++ IS
Sbjct: 199 ---------GSSNAVEALIKKGADLNLVDSLGY-NALHYSKLSENAGIQSLLLSKIS 245
Score = 51.2 bits (117), Expect = 4e-05
Identities = 57/196 (29%), Positives = 85/196 (43%), Gaps = 25/196 (12%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTND--NYTALHIAVESCKPAVVETLLGYG 719
+G + H AA GHV + ++ G VDVT D ++ALH+A ++ + LL
Sbjct: 55 EGKTAFHLAAAKGHVECLRVMITHG--VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSK 112
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP-NKATEDGMTPVHVAAKFGNLA 778
+T LH AA G A+ +L P N DG P+ +A + G+
Sbjct: 113 CPAE-SVDSSGKTALHYAA--AQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSE 169
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
LL+ G D + K +G T L +AC + V LI+ KG A
Sbjct: 170 ICHFLLDHGADVNSRNK-------SGRTALMLACEIGSSNAVEALIK-----KG-----A 212
Query: 839 FIDAVDEDGASALHYA 854
++ VD G +ALHY+
Sbjct: 213 DLNLVDSLGYNALHYS 228
Score = 48.4 bits (110), Expect = 3e-04
Identities = 38/158 (24%), Positives = 70/158 (44%), Gaps = 3/158 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L LA + + +R+LL ++ + + +G TALH AA + + +IL ++ +
Sbjct: 89 GHSALHLAAKNSHHECIRKLLQSKCPAE--SVDSSGKTALHYAAAQGCLQAVQILCEHKS 146
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
++ + G PL +A G + + A+ + RT + LA E G + +E
Sbjct: 147 PINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEA 206
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L K A + G +H + L+ +A +L K
Sbjct: 207 LIKK-GADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 243
Score = 35.9 bits (79), Expect = 1.6
Identities = 22/66 (33%), Positives = 31/66 (46%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K DG + A + GH I + LL G V+ TAL +A E VE L+
Sbjct: 151 KDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKK 210
Query: 719 GADVHI 724
GAD+++
Sbjct: 211 GADLNL 216
>AK057782-1|BAB71569.1| 268|Homo sapiens protein ( Homo sapiens cDNA
FLJ25053 fis, clone CBL04266. ).
Length = 268
Score = 95.9 bits (228), Expect = 1e-18
Identities = 70/222 (31%), Positives = 113/222 (50%), Gaps = 6/222 (2%)
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
AA G L+K L+ +D T L +AA +G I+ + L+ GA+I+ E
Sbjct: 19 AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
G + AAQ +++VV+ FL TKDG T A+ G ++V+E L+K
Sbjct: 79 GTTALFFAAQQGHNDVVR-FLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGA- 136
Query: 1122 GVISARNKLND-STPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNV 1180
+ ++L D +T L LAA+GG+ DV+R+L+ +GA + G + +A++ GH+ V
Sbjct: 137 ---NIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEV 193
Query: 1181 LDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVP 1222
+ VM R +++ G T L AA G + ++ELL P
Sbjct: 194 VRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSP 235
Score = 95.1 bits (226), Expect = 2e-18
Identities = 67/203 (33%), Positives = 107/203 (52%), Gaps = 3/203 (1%)
Query: 925 QNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTN 984
++S G T L++A + GH+ V L+ A +++ G +AL AA+ G+ V L
Sbjct: 42 RDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGF 101
Query: 985 KAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEV 1044
A + ++G TAL A+ G+ +V+ L++ H A I T L LAA G ++V
Sbjct: 102 GASTEFRTKDGGTALLAASQYGHMQVVETLLK-HGANIHDQLYDGATALFLAAQGGYLDV 160
Query: 1045 CKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAA 1104
+LLL GA ++ + G P+ A+Q +SEVV++ L + + A DG T AA
Sbjct: 161 IRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRD-AARNDGTTALLKAA 219
Query: 1105 IQGSVKVIEELMKFDRT-GVISA 1126
+G VI+EL+KF T G++ A
Sbjct: 220 NKGYNDVIKELLKFSPTLGILKA 242
Score = 93.5 bits (222), Expect = 7e-18
Identities = 66/196 (33%), Positives = 98/196 (50%), Gaps = 7/196 (3%)
Query: 1244 GLTPLHLAAYNGNENVVR-LLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRS 1302
G T L +AAY G+ + VR L+L A + E+G L A GH +V L
Sbjct: 46 GTTLLMVAAYAGHIDCVRELVLQGADINLQ---RESGTTALFFAAQQGHNDVVRFLFGFG 102
Query: 1303 AELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVV 1362
A T + G T L AS +GH Q+VE LL GA I+ +G T L AA+ G+L+V+
Sbjct: 103 ASTEFRT-KDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVI 161
Query: 1363 KLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCS 1422
+LL SGA AP+W A+ H++V+ +L + D + +D L +
Sbjct: 162 RLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTAL-LKAAN 220
Query: 1423 KNHNNIPIEEFVLVSP 1438
K +N++ I+E + SP
Sbjct: 221 KGYNDV-IKELLKFSP 235
Score = 92.7 bits (220), Expect = 1e-17
Identities = 65/215 (30%), Positives = 107/215 (49%), Gaps = 8/215 (3%)
Query: 875 LIENGADVSLQTRHNHETAF-HYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPL 933
L+ N V + R +H T A AG+ D + E++ + AD+ N Q G T L
Sbjct: 30 LLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELV--LQGADI----NLQRESGTTAL 83
Query: 934 LIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKAR 993
A +GH +V L A + +G +AL A+++G++QV + LL + A I+ +
Sbjct: 84 FFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLY 143
Query: 994 NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA 1053
+G TAL LAA GY +++ L+ A ++ PL +A+ G EV +++L GA
Sbjct: 144 DGATALFLAAQGGYLDVIRLLLAS-GAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGA 202
Query: 1054 NIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNL 1088
+ DA G + AA Y++V++ L+ P L
Sbjct: 203 DRDAARNDGTTALLKAANKGYNDVIKELLKFSPTL 237
Score = 90.6 bits (215), Expect = 5e-17
Identities = 70/233 (30%), Positives = 112/233 (48%), Gaps = 17/233 (7%)
Query: 1168 AVHLAAEHGHTNVLDVMRSTNTLRISSKKL-GLTPLHIAAYYGQAETVRELLSHVPGTVK 1226
A AA G+ +L ++ ++ + + + G T L +AAY G + VREL+
Sbjct: 15 AAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQ------ 68
Query: 1227 SEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLA 1286
G + L ESG T L AA G+ +VVR L G + + + G L A
Sbjct: 69 -----GADIN--LQRESGTTALFFAAQQGHNDVVRFLF-GFGASTEFRTKDGG-TALLAA 119
Query: 1287 CFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNG 1346
GHM +V LL A +H G T L +A+ G+ ++ +LL GA++N ++G
Sbjct: 120 SQYGHMQVVETLLKHGAN-IHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDG 178
Query: 1347 WTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
PL A++ GH VV+++ GA + N + AA++ +NDV++ LL
Sbjct: 179 TAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELL 231
Score = 81.0 bits (191), Expect = 4e-14
Identities = 71/220 (32%), Positives = 107/220 (48%), Gaps = 8/220 (3%)
Query: 936 ACHRGHMQLVNTLLTNHARVDVF--DVEGRSALHLAAEHGYLQVCDALLTNKAFINSKAR 993
A RG++ L+ LL N RVDV D G + L +AA G++ L+ A IN +
Sbjct: 19 AARRGNLALLKLLL-NSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRE 77
Query: 994 NGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGA 1053
+G TAL AA G+ +V+FL A + T T L A+ G ++V + LL+ GA
Sbjct: 78 SGTTALFFAAQQGHNDVVRFLF-GFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGA 136
Query: 1054 NIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIE 1113
NI G + AAQ Y +V++L L V +DG IA+ G +V+
Sbjct: 137 NIHDQLYDGATALFLAAQGGYLDVIRLLLASGAK-VNQPRQDGTAPLWIASQMGHSEVV- 194
Query: 1114 ELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVR 1153
+M +ARN + +T L AA G+ DV++ L++
Sbjct: 195 RVMLLRGADRDAARN--DGTTALLKAANKGYNDVIKELLK 232
Score = 79.4 bits (187), Expect = 1e-13
Identities = 59/184 (32%), Positives = 93/184 (50%), Gaps = 8/184 (4%)
Query: 872 VKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWT 931
V+ L+ GAD++LQ R + TA + A G+NDV+ + ++ + + G T
Sbjct: 62 VRELVLQGADINLQ-RESGTTALFFAAQQGHNDVVRFLFGFGASTEF------RTKDGGT 114
Query: 932 PLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSK 991
LL A GHMQ+V TLL + A + +G +AL LAA+ GYL V LL + A +N
Sbjct: 115 ALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQP 174
Query: 992 ARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLEL 1051
++G L +A+ G++ +V+ ++ A D T L AA G +V K LL+
Sbjct: 175 RQDGTAPLWIASQMGHSEVVRVMLL-RGADRDAARNDGTTALLKAANKGYNDVIKELLKF 233
Query: 1052 GANI 1055
+
Sbjct: 234 SPTL 237
Score = 72.1 bits (169), Expect = 2e-11
Identities = 43/160 (26%), Positives = 80/160 (50%), Gaps = 2/160 (1%)
Query: 70 AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNG 129
A GN ++++ LL++ + + G T L +AA +D R LV GA ++
Sbjct: 19 AARRGNLALLKLLLNSGRVD-VDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRE 77
Query: 130 AGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKA 189
+G T L AA +G +V++ +G A+ + T + A++ GH ++E L K A
Sbjct: 78 SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLL-KHGA 136
Query: 190 SIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+I ++ DG+T + +A+ G+ D +L G ++ P +
Sbjct: 137 NIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQ 176
Score = 60.9 bits (141), Expect = 5e-08
Identities = 50/164 (30%), Positives = 78/164 (47%), Gaps = 9/164 (5%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA+ GH ++ L G S + T D TAL A + VVETLL +GA++
Sbjct: 79 GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
H + T L +AA+ D L LL SGA N+ +DG P+ +A++ G+ + +
Sbjct: 139 HDQ-LYDGATALFLAAQGGYLDVIRL-LLASGAKVNQPRQDGTAPLWIASQMGHSEVVRV 196
Query: 783 LLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEF 826
+L G D G T L A D+++ L++F
Sbjct: 197 MLLRGADRDAARN-------DGTTALLKAANKGYNDVIKELLKF 233
Score = 59.3 bits (137), Expect = 1e-07
Identities = 47/159 (29%), Positives = 77/159 (48%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L++A AG+ VREL+ Q A+ + +G TAL AA++ D+ R L +GA
Sbjct: 46 GTTLLMVAAYAGHIDCVRELV-LQGAD-INLQRESGTTALFFAAQQGHNDVVRFLFGFGA 103
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
+ G T L A+ G +V+ AN + T + LAA+ G+ +I L
Sbjct: 104 STEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRL 163
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L A + + +DG+ + IAS GH++ ++ +G
Sbjct: 164 LLAS-GAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRG 201
Score = 58.4 bits (135), Expect = 3e-07
Identities = 39/129 (30%), Positives = 67/129 (51%), Gaps = 2/129 (1%)
Query: 647 RMIFWDTFFEKYKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVES 706
R +F +++ DG ++ A++YGH+ ++ TLL+ G ++ D TAL +A +
Sbjct: 96 RFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQG 155
Query: 707 CKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMT 766
V+ LL GA V+ + + PL IA+++ + +MLL+ GA + A DG T
Sbjct: 156 GYLDVIRLLLASGAKVN-QPRQDGTAPLWIASQMGHSEVVRVMLLR-GADRDAARNDGTT 213
Query: 767 PVHVAAKFG 775
+ AA G
Sbjct: 214 ALLKAANKG 222
Score = 54.0 bits (124), Expect = 5e-06
Identities = 66/246 (26%), Positives = 110/246 (44%), Gaps = 32/246 (13%)
Query: 771 AAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDH 830
AA+ GNLA L LLL G + V D G T L +A + D VR L+
Sbjct: 19 AARRGNLALLKLLLNSG-----RVDVDCRD-SHGTTLLMVAAYAGHIDCVRELV------ 66
Query: 831 KGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNH 890
+ A I+ E G +AL +A + VV+ L GA +T+ +
Sbjct: 67 ----LQGADINLQRESGTTALFFAAQ---------QGHNDVVRFLFGFGASTEFRTK-DG 112
Query: 891 ETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLT 950
TA + G+ V+ ++ H ++ Q G T L +A G++ ++ LL
Sbjct: 113 GTALLAASQYGHMQVVETLLKH------GANIHDQLYDGATALFLAAQGGYLDVIRLLLA 166
Query: 951 NHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHL 1010
+ A+V+ +G + L +A++ G+ +V +L A ++ +G TAL AA GY +
Sbjct: 167 SGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDV 226
Query: 1011 VKFLIR 1016
+K L++
Sbjct: 227 IKELLK 232
Score = 50.4 bits (115), Expect = 7e-05
Identities = 39/125 (31%), Positives = 56/125 (44%), Gaps = 2/125 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G + AA GH+ + L+ +G +++ TAL A + VV L G+GA
Sbjct: 46 GTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGAST 105
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
R K T L +AA + LLK GA + DG T + +AA+ G L + L
Sbjct: 106 EFR-TKDGGTAL-LAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRL 163
Query: 783 LLEDG 787
LL G
Sbjct: 164 LLASG 168
Score = 46.4 bits (105), Expect = 0.001
Identities = 42/131 (32%), Positives = 63/131 (48%), Gaps = 7/131 (5%)
Query: 63 GKVPLLLAVEAGNQSMVRELLS--AQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
G LL A + G+ +V LL A +QL G TAL LAA+ +D+ R+L+
Sbjct: 112 GGTALLAASQYGHMQVVETLLKHGANIHDQLYD----GATALFLAAQGGYLDVIRLLLAS 167
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+ G PL IA+ G +V+ A+ A N+ T + AA G+ +I
Sbjct: 168 GAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVI 227
Query: 181 ELLADKFKASI 191
+ L KF ++
Sbjct: 228 KELL-KFSPTL 237
Score = 45.6 bits (103), Expect = 0.002
Identities = 39/165 (23%), Positives = 72/165 (43%), Gaps = 5/165 (3%)
Query: 57 DLVFQR--GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMA 114
D+ QR G L A + G+ +VR L + + + T G TAL A++ + +
Sbjct: 71 DINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFR--TKDGGTALLAASQYGHMQVV 128
Query: 115 RILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAEN 174
L+ +GA + G T L +AA G +++ A + P+ +A++
Sbjct: 129 ETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQM 188
Query: 175 GHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
GH+ ++ ++ + A DG+T + A+ G+ D L K
Sbjct: 189 GHSEVVRVMLLR-GADRDAARNDGTTALLKAANKGYNDVIKELLK 232
Score = 37.9 bits (84), Expect = 0.39
Identities = 28/99 (28%), Positives = 44/99 (44%), Gaps = 7/99 (7%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DG + A++ GH ++ +L +G D ND TAL A V++ LL +
Sbjct: 177 DGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPT 236
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKA 760
+ I K E P + ++ L LL+S GP K+
Sbjct: 237 LGIL--KANELPAELTK-----NERILRLLRSKEGPRKS 268
>AF155135-1|AAF44722.1| 980|Homo sapiens novel retinal pigment
epithelial cell protein protein.
Length = 980
Score = 95.9 bits (228), Expect = 1e-18
Identities = 64/230 (27%), Positives = 106/230 (46%), Gaps = 4/230 (1%)
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A NG A V L+ A + +T HLAAA G +E ++++ G ++ A D
Sbjct: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 85
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
G +H AA+N++ E ++ LQ + G T H AA QG ++ ++ L +
Sbjct: 86 GHSALHLAAKNSHHECIRRLLQSKCP-AESVDSSGKTALHYAAAQGCLQAVQILC--EHK 142
Query: 1122 GVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVL 1181
I+ ++ L+ + PL LA + GH+++ L+ GA N++G TA+ LA E G +N +
Sbjct: 143 SPINLKD-LDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 201
Query: 1182 DVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT 1231
+ + LG LH + A LLS + + PT
Sbjct: 202 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPT 251
Score = 93.5 bits (222), Expect = 7e-18
Identities = 65/223 (29%), Positives = 107/223 (47%), Gaps = 11/223 (4%)
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHE--TAFHYCAIAGNNDVMTEMIAHISTADVSRA 921
+ D + V L+ G + T+H+ E TAFH A G+ + + MI H DV+
Sbjct: 27 VENGDAEKVASLL--GKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITH--GVDVT-- 80
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
Q++ G + L +A H + + LL + + D G++ALH AA G LQ L
Sbjct: 81 --AQDTTGHSALHLAAKNSHHECIRRLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQIL 138
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
+K+ IN K +G L LA NG++ + FL+ DH A ++ +T L LA G
Sbjct: 139 CEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLL-DHGADVNSRNKSGRTALMLACEIGS 197
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
+ L++ GA+++ D LG +H + + + + L L +
Sbjct: 198 SNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
Score = 88.6 bits (210), Expect = 2e-16
Identities = 50/165 (30%), Positives = 89/165 (53%), Gaps = 1/165 (0%)
Query: 924 RQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLT 983
+ +S G T +A +GH++ + ++T+ V D G SALHLAA++ + + LL
Sbjct: 48 KHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRRLLQ 107
Query: 984 NKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIE 1043
+K S +G+TALH AA G V+ L +H + I++ L PL LA +G E
Sbjct: 108 SKCPAESVDSSGKTALHYAAAQGCLQAVQILC-EHKSPINLKDLDGNIPLLLAVQNGHSE 166
Query: 1044 VCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNL 1088
+C LL+ GA++++ ++ G+ + A + S V+ +++ +L
Sbjct: 167 ICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADL 211
Score = 88.2 bits (209), Expect = 3e-16
Identities = 73/235 (31%), Positives = 103/235 (43%), Gaps = 16/235 (6%)
Query: 1131 NDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTL 1190
ND LQ G V +L + GAS T + G TA HLAA GH L VM +
Sbjct: 19 NDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVD 78
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHL 1250
+ G + LH+AA E +R LL +S+ P SG T LH
Sbjct: 79 VTAQDTTGHSALHLAAKNSHHECIRRLL-------QSKCPAESV------DSSGKTALHY 125
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AA G V++L + +G PL LA GH I LL A+ ++S +
Sbjct: 126 AAAQGCLQAVQILCEHK--SPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGAD-VNSRN 182
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
+ G+T L +A G VE L+ +GA++N D G+ LH + + + + LL
Sbjct: 183 KSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLL 237
Score = 79.4 bits (187), Expect = 1e-13
Identities = 58/192 (30%), Positives = 85/192 (44%), Gaps = 6/192 (3%)
Query: 1244 GLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSA 1303
G T HLAA G+ +R+++ GV A + G++ LHLA H + LL
Sbjct: 53 GKTAFHLAAAKGHVECLRVMITH-GVDV-TAQDTTGHSALHLAAKNSHHECIRRLLQSKC 110
Query: 1304 ELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVK 1363
S D GKT LH A+ G Q V++L + IN D +G PL A + GH +
Sbjct: 111 PA-ESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICH 169
Query: 1364 LLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSK 1423
L + GA S + A ++ +E L+ K D +L+D YN + SK
Sbjct: 170 FLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADL-NLVDS--LGYNALHYSK 226
Query: 1424 NHNNIPIEEFVL 1435
N I+ +L
Sbjct: 227 LSENAGIQSLLL 238
Score = 77.0 bits (181), Expect = 7e-13
Identities = 48/163 (29%), Positives = 79/163 (48%), Gaps = 2/163 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
LL AVE G+ V LL + A K + G TA HLAA + V+ R+++ +G V A
Sbjct: 23 LLQAVENGDAEKVASLLGKKGASATKHDSE-GKTAFHLAAAKGHVECLRVMITHGVDVTA 81
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G + LH+AA ++ + A D+ +T +H AA G +++L +
Sbjct: 82 QDTTGHSALHLAAKNSHHECIRRLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCE- 140
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
K+ I + DG+ + +A NGH++ L G ++ NK
Sbjct: 141 HKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK 183
Score = 70.9 bits (166), Expect = 4e-11
Identities = 48/164 (29%), Positives = 79/164 (48%), Gaps = 3/164 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
GK LA G+ +R +++ + TT G +ALHLAA+ + R L+
Sbjct: 53 GKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT--GHSALHLAAKNSHHECIRRLLQSKC 110
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
++ + +G+T LH AAA+G V+ ++ + D + P+ LA +NGH+ I
Sbjct: 111 PAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHF 170
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHM 226
L D A + R K G T + +A G ++ L KKG L++
Sbjct: 171 LLDH-GADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNL 213
Score = 68.1 bits (159), Expect = 3e-10
Identities = 56/204 (27%), Positives = 93/204 (45%), Gaps = 16/204 (7%)
Query: 1198 GLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNE 1257
G T H+AA G E +R +++H GV + +G + LHLAA N +
Sbjct: 53 GKTAFHLAAAKGHVECLRVMITH-----------GVDVTAQ--DTTGHSALHLAAKNSHH 99
Query: 1258 NVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGL 1317
+R LL S A++ + +G LH A G + V +L + + + D G L
Sbjct: 100 ECIRRLLQSK-CPAESVDS-SGKTALHYAAAQGCLQAVQILCEHKSPI-NLKDLDGNIPL 156
Query: 1318 HIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETN 1377
+A +GH ++ LL GA++N+ +K+G T L A + G N V+ L + GA +
Sbjct: 157 LLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDS 216
Query: 1378 LNCAPIWFAASENHNDVLEYLLHK 1401
L + ++ + + LL K
Sbjct: 217 LGYNALHYSKLSENAGIQSLLLSK 240
Score = 58.8 bits (136), Expect = 2e-07
Identities = 60/226 (26%), Positives = 101/226 (44%), Gaps = 33/226 (14%)
Query: 742 DGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDV 801
D +K A +L K GA K +G T H+AA G++ L +++ G D V D
Sbjct: 31 DAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVD------VTAQD- 83
Query: 802 VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEE 861
TG + L +A ++ + +R L++ S ++VD G +ALHYA
Sbjct: 84 TTGHSALHLAAKNSHHECIRRLLQ----------SKCPAESVDSSGKTALHYAA------ 127
Query: 862 VKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRA 921
Q V+ L E+ + ++L+ + G++++ ++ H ADV
Sbjct: 128 ---AQGCLQAVQILCEHKSPINLKDLDGN-IPLLLAVQNGHSEICHFLLDH--GADV--- 178
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALH 967
N +N G T L++AC G V L+ A +++ D G +ALH
Sbjct: 179 -NSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALH 223
Score = 57.2 bits (132), Expect = 6e-07
Identities = 40/157 (25%), Positives = 71/157 (45%), Gaps = 3/157 (1%)
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP 1349
G V LL + D GKT H+A+ GH + + V++ G ++ A D G +
Sbjct: 30 GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSA 89
Query: 1350 LHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLM 1409
LH AAK H ++ L +S +S + + +AA++ ++ L EH + +
Sbjct: 90 LHLAAKNSHHECIRRLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILC--EHKSPINL 147
Query: 1410 DDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAK 1446
D L++ +N ++ I F+L A V++ K
Sbjct: 148 KDLDGNIPLLLAVQNGHS-EICHFLLDHGADVNSRNK 183
Score = 56.0 bits (129), Expect = 1e-06
Identities = 52/190 (27%), Positives = 84/190 (44%), Gaps = 16/190 (8%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+ A D G SALH A K + E ++ L+++ + +TA HY A
Sbjct: 79 VTAQDTTGHSALHLAAKNSHHEC---------IRRLLQSKCPAE-SVDSSGKTALHYAAA 128
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
G + + H S +N ++ G PLL+A GH ++ + LL + A V+ +
Sbjct: 129 QGCLQAVQILCEHKSP------INLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRN 182
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
GR+AL LA E G +AL+ A +N G ALH + ++ A + L+ +
Sbjct: 183 KSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKIS 242
Query: 1020 AMIDVLTLKK 1029
D+ T K
Sbjct: 243 QDADLKTPTK 252
Score = 54.0 bits (124), Expect = 5e-06
Identities = 56/237 (23%), Positives = 105/237 (44%), Gaps = 29/237 (12%)
Query: 678 IINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIA 737
+ + L +KG S ++ TA H+A + ++ +G DV + + LH+A
Sbjct: 35 VASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ-DTTGHSALHLA 93
Query: 738 ARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVC 797
A+ +C LL+S G T +H AA G L + +L E K+ +
Sbjct: 94 AK-NSHHECIRRLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCE------HKSPIN 146
Query: 798 IYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKV 857
+ D + G PL +A ++ +I F+ DH + +++ ++ G +AL AC++
Sbjct: 147 LKD-LDGNIPLLLAVQNGHSEI----CHFLLDHGAD------VNSRNKSGRTALMLACEI 195
Query: 858 TKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHIS 914
V+ LI+ GAD++L + A HY ++ N + + +++ IS
Sbjct: 196 ---------GSSNAVEALIKKGADLNLVDSLGY-NALHYSKLSENAGIQSLLLSKIS 242
Score = 51.2 bits (117), Expect = 4e-05
Identities = 57/196 (29%), Positives = 85/196 (43%), Gaps = 25/196 (12%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTND--NYTALHIAVESCKPAVVETLLGYG 719
+G + H AA GHV + ++ G VDVT D ++ALH+A ++ + LL
Sbjct: 52 EGKTAFHLAAAKGHVECLRVMITHG--VDVTAQDTTGHSALHLAAKNSHHECIRRLLQSK 109
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP-NKATEDGMTPVHVAAKFGNLA 778
+T LH AA G A+ +L P N DG P+ +A + G+
Sbjct: 110 CPAE-SVDSSGKTALHYAA--AQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSE 166
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
LL+ G D + K +G T L +AC + V LI+ KG A
Sbjct: 167 ICHFLLDHGADVNSRNK-------SGRTALMLACEIGSSNAVEALIK-----KG-----A 209
Query: 839 FIDAVDEDGASALHYA 854
++ VD G +ALHY+
Sbjct: 210 DLNLVDSLGYNALHYS 225
Score = 48.0 bits (109), Expect = 4e-04
Identities = 38/158 (24%), Positives = 69/158 (43%), Gaps = 3/158 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L LA + + +R LL ++ + + +G TALH AA + + +IL ++ +
Sbjct: 86 GHSALHLAAKNSHHECIRRLLQSKCPAE--SVDSSGKTALHYAAAQGCLQAVQILCEHKS 143
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
++ + G PL +A G + + A+ + RT + LA E G + +E
Sbjct: 144 PINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEA 203
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L K A + G +H + L+ +A +L K
Sbjct: 204 LIKK-GADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
Score = 35.9 bits (79), Expect = 1.6
Identities = 22/66 (33%), Positives = 31/66 (46%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K DG + A + GH I + LL G V+ TAL +A E VE L+
Sbjct: 148 KDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKK 207
Query: 719 GADVHI 724
GAD+++
Sbjct: 208 GADLNL 213
>AB037755-1|BAA92572.1| 989|Homo sapiens KIAA1334 protein protein.
Length = 989
Score = 95.9 bits (228), Expect = 1e-18
Identities = 64/230 (27%), Positives = 106/230 (46%), Gaps = 4/230 (1%)
Query: 1002 AAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDEL 1061
A NG A V L+ A + +T HLAAA G +E ++++ G ++ A D
Sbjct: 35 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 94
Query: 1062 GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRT 1121
G +H AA+N++ E ++ LQ + G T H AA QG ++ ++ L +
Sbjct: 95 GHSALHLAAKNSHHECIRKLLQSKCP-AESVDSSGKTALHYAAAQGCLQAVQILC--EHK 151
Query: 1122 GVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVL 1181
I+ ++ L+ + PL LA + GH+++ L+ GA N++G TA+ LA E G +N +
Sbjct: 152 SPINLKD-LDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 210
Query: 1182 DVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT 1231
+ + LG LH + A LLS + + PT
Sbjct: 211 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPT 260
Score = 93.5 bits (222), Expect = 7e-18
Identities = 65/223 (29%), Positives = 107/223 (47%), Gaps = 11/223 (4%)
Query: 864 IPTADRQVVKCLIENGADVSLQTRHNHE--TAFHYCAIAGNNDVMTEMIAHISTADVSRA 921
+ D + V L+ G + T+H+ E TAFH A G+ + + MI H DV+
Sbjct: 36 VENGDAEKVASLL--GKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITH--GVDVT-- 89
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
Q++ G + L +A H + + LL + + D G++ALH AA G LQ L
Sbjct: 90 --AQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQIL 147
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
+K+ IN K +G L LA NG++ + FL+ DH A ++ +T L LA G
Sbjct: 148 CEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLL-DHGADVNSRNKSGRTALMLACEIGS 206
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
+ L++ GA+++ D LG +H + + + + L L +
Sbjct: 207 SNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 249
Score = 88.6 bits (210), Expect = 2e-16
Identities = 73/235 (31%), Positives = 104/235 (44%), Gaps = 16/235 (6%)
Query: 1131 NDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTL 1190
ND LQ G V +L + GAS T + G TA HLAA GH L VM +
Sbjct: 28 NDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVD 87
Query: 1191 RISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHL 1250
+ G + LH+AA E +R+LL +S+ P SG T LH
Sbjct: 88 VTAQDTTGHSALHLAAKNSHHECIRKLL-------QSKCPAESV------DSSGKTALHY 134
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AA G V++L + +G PL LA GH I LL A+ ++S +
Sbjct: 135 AAAQGCLQAVQILCEHK--SPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGAD-VNSRN 191
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
+ G+T L +A G VE L+ +GA++N D G+ LH + + + + LL
Sbjct: 192 KSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLL 246
Score = 88.6 bits (210), Expect = 2e-16
Identities = 50/165 (30%), Positives = 89/165 (53%), Gaps = 1/165 (0%)
Query: 924 RQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLT 983
+ +S G T +A +GH++ + ++T+ V D G SALHLAA++ + + LL
Sbjct: 57 KHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQ 116
Query: 984 NKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIE 1043
+K S +G+TALH AA G V+ L +H + I++ L PL LA +G E
Sbjct: 117 SKCPAESVDSSGKTALHYAAAQGCLQAVQILC-EHKSPINLKDLDGNIPLLLAVQNGHSE 175
Query: 1044 VCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNL 1088
+C LL+ GA++++ ++ G+ + A + S V+ +++ +L
Sbjct: 176 ICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADL 220
Score = 79.4 bits (187), Expect = 1e-13
Identities = 58/192 (30%), Positives = 85/192 (44%), Gaps = 6/192 (3%)
Query: 1244 GLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSA 1303
G T HLAA G+ +R+++ GV A + G++ LHLA H + LL
Sbjct: 62 GKTAFHLAAAKGHVECLRVMITH-GVDV-TAQDTTGHSALHLAAKNSHHECIRKLLQSKC 119
Query: 1304 ELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVK 1363
S D GKT LH A+ G Q V++L + IN D +G PL A + GH +
Sbjct: 120 PA-ESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICH 178
Query: 1364 LLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSK 1423
L + GA S + A ++ +E L+ K D +L+D YN + SK
Sbjct: 179 FLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADL-NLVDS--LGYNALHYSK 235
Query: 1424 NHNNIPIEEFVL 1435
N I+ +L
Sbjct: 236 LSENAGIQSLLL 247
Score = 77.0 bits (181), Expect = 7e-13
Identities = 48/163 (29%), Positives = 79/163 (48%), Gaps = 2/163 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
LL AVE G+ V LL + A K + G TA HLAA + V+ R+++ +G V A
Sbjct: 32 LLQAVENGDAEKVASLLGKKGASATKHDSE-GKTAFHLAAAKGHVECLRVMITHGVDVTA 90
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
+ G + LH+AA ++ + A D+ +T +H AA G +++L +
Sbjct: 91 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCE- 149
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
K+ I + DG+ + +A NGH++ L G ++ NK
Sbjct: 150 HKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK 192
Score = 70.9 bits (166), Expect = 4e-11
Identities = 48/164 (29%), Positives = 79/164 (48%), Gaps = 3/164 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
GK LA G+ +R +++ + TT G +ALHLAA+ + R L+
Sbjct: 62 GKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT--GHSALHLAAKNSHHECIRKLLQSKC 119
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
++ + +G+T LH AAA+G V+ ++ + D + P+ LA +NGH+ I
Sbjct: 120 PAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHF 179
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHM 226
L D A + R K G T + +A G ++ L KKG L++
Sbjct: 180 LLDH-GADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNL 222
Score = 68.1 bits (159), Expect = 3e-10
Identities = 56/204 (27%), Positives = 93/204 (45%), Gaps = 16/204 (7%)
Query: 1198 GLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNE 1257
G T H+AA G E +R +++H GV + +G + LHLAA N +
Sbjct: 62 GKTAFHLAAAKGHVECLRVMITH-----------GVDVTAQ--DTTGHSALHLAAKNSHH 108
Query: 1258 NVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGL 1317
+R LL S A++ + +G LH A G + V +L + + + D G L
Sbjct: 109 ECIRKLLQSK-CPAESVDS-SGKTALHYAAAQGCLQAVQILCEHKSPI-NLKDLDGNIPL 165
Query: 1318 HIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETN 1377
+A +GH ++ LL GA++N+ +K+G T L A + G N V+ L + GA +
Sbjct: 166 LLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDS 225
Query: 1378 LNCAPIWFAASENHNDVLEYLLHK 1401
L + ++ + + LL K
Sbjct: 226 LGYNALHYSKLSENAGIQSLLLSK 249
Score = 58.4 bits (135), Expect = 3e-07
Identities = 60/226 (26%), Positives = 101/226 (44%), Gaps = 33/226 (14%)
Query: 742 DGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDV 801
D +K A +L K GA K +G T H+AA G++ L +++ G D V D
Sbjct: 40 DAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVD------VTAQD- 92
Query: 802 VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEE 861
TG + L +A ++ + +R L++ S ++VD G +ALHYA
Sbjct: 93 TTGHSALHLAAKNSHHECIRKLLQ----------SKCPAESVDSSGKTALHYAA------ 136
Query: 862 VKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRA 921
Q V+ L E+ + ++L+ + G++++ ++ H ADV
Sbjct: 137 ---AQGCLQAVQILCEHKSPINLKDLDGN-IPLLLAVQNGHSEICHFLLDH--GADV--- 187
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALH 967
N +N G T L++AC G V L+ A +++ D G +ALH
Sbjct: 188 -NSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALH 232
Score = 57.2 bits (132), Expect = 6e-07
Identities = 40/157 (25%), Positives = 71/157 (45%), Gaps = 3/157 (1%)
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP 1349
G V LL + D GKT H+A+ GH + + V++ G ++ A D G +
Sbjct: 39 GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSA 98
Query: 1350 LHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHDTQSLM 1409
LH AAK H ++ L +S +S + + +AA++ ++ L EH + +
Sbjct: 99 LHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILC--EHKSPINL 156
Query: 1410 DDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVDTAAK 1446
D L++ +N ++ I F+L A V++ K
Sbjct: 157 KDLDGNIPLLLAVQNGHS-EICHFLLDHGADVNSRNK 192
Score = 56.0 bits (129), Expect = 1e-06
Identities = 52/190 (27%), Positives = 84/190 (44%), Gaps = 16/190 (8%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
+ A D G SALH A K + E ++ L+++ + +TA HY A
Sbjct: 88 VTAQDTTGHSALHLAAKNSHHEC---------IRKLLQSKCPAE-SVDSSGKTALHYAAA 137
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
G + + H S +N ++ G PLL+A GH ++ + LL + A V+ +
Sbjct: 138 QGCLQAVQILCEHKSP------INLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRN 191
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
GR+AL LA E G +AL+ A +N G ALH + ++ A + L+ +
Sbjct: 192 KSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKIS 251
Query: 1020 AMIDVLTLKK 1029
D+ T K
Sbjct: 252 QDADLKTPTK 261
Score = 54.0 bits (124), Expect = 5e-06
Identities = 56/237 (23%), Positives = 105/237 (44%), Gaps = 29/237 (12%)
Query: 678 IINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIA 737
+ + L +KG S ++ TA H+A + ++ +G DV + + LH+A
Sbjct: 44 VASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ-DTTGHSALHLA 102
Query: 738 ARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVC 797
A+ +C LL+S G T +H AA G L + +L E K+ +
Sbjct: 103 AK-NSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCE------HKSPIN 155
Query: 798 IYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKV 857
+ D + G PL +A ++ +I F+ DH + +++ ++ G +AL AC++
Sbjct: 156 LKD-LDGNIPLLLAVQNGHSEI----CHFLLDHGAD------VNSRNKSGRTALMLACEI 204
Query: 858 TKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHIS 914
V+ LI+ GAD++L + A HY ++ N + + +++ IS
Sbjct: 205 ---------GSSNAVEALIKKGADLNLVDSLGY-NALHYSKLSENAGIQSLLLSKIS 251
Score = 51.2 bits (117), Expect = 4e-05
Identities = 57/196 (29%), Positives = 85/196 (43%), Gaps = 25/196 (12%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTND--NYTALHIAVESCKPAVVETLLGYG 719
+G + H AA GHV + ++ G VDVT D ++ALH+A ++ + LL
Sbjct: 61 EGKTAFHLAAAKGHVECLRVMITHG--VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSK 118
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP-NKATEDGMTPVHVAAKFGNLA 778
+T LH AA G A+ +L P N DG P+ +A + G+
Sbjct: 119 CPAE-SVDSSGKTALHYAA--AQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSE 175
Query: 779 TLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTA 838
LL+ G D + K +G T L +AC + V LI+ KG A
Sbjct: 176 ICHFLLDHGADVNSRNK-------SGRTALMLACEIGSSNAVEALIK-----KG-----A 218
Query: 839 FIDAVDEDGASALHYA 854
++ VD G +ALHY+
Sbjct: 219 DLNLVDSLGYNALHYS 234
Score = 48.4 bits (110), Expect = 3e-04
Identities = 38/158 (24%), Positives = 70/158 (44%), Gaps = 3/158 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L LA + + +R+LL ++ + + +G TALH AA + + +IL ++ +
Sbjct: 95 GHSALHLAAKNSHHECIRKLLQSKCPAE--SVDSSGKTALHYAAAQGCLQAVQILCEHKS 152
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
++ + G PL +A G + + A+ + RT + LA E G + +E
Sbjct: 153 PINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEA 212
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
L K A + G +H + L+ +A +L K
Sbjct: 213 LIKK-GADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 249
Score = 35.9 bits (79), Expect = 1.6
Identities = 22/66 (33%), Positives = 31/66 (46%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K DG + A + GH I + LL G V+ TAL +A E VE L+
Sbjct: 157 KDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKK 216
Query: 719 GADVHI 724
GAD+++
Sbjct: 217 GADLNL 222
>AY281131-1|AAP37612.1| 1249|Homo sapiens AIDA-1b protein.
Length = 1249
Score = 95.5 bits (227), Expect = 2e-18
Identities = 79/277 (28%), Positives = 135/277 (48%), Gaps = 29/277 (10%)
Query: 1103 AAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDEN 1162
AA G+V ++E+L+ + G++ S PL L+ +++ + +CTD +
Sbjct: 10 AARTGNVALVEKLLSGRKGGILGG-----GSGPLPLS------NLLSIWRGPNVNCTDSS 58
Query: 1163 RAGLTAVHLAAEHGHTN-VLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHV 1221
G TA+H AA +GH + VL +++ + ++ K G P+H+AA+ G E V+ L+ H
Sbjct: 59 --GYTALHHAALNGHKDIVLKLLQYEASTNVADNK-GYFPIHLAAWKGDVEIVKILIHHG 115
Query: 1222 PGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYN 1281
P + T LH AA G+ VV +LL + N
Sbjct: 116 PSHSRVNEQNN----------ENETALHCAAQYGHSEVVAVLLEE--LTDPTIRNSKLET 163
Query: 1282 PLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINA 1341
PL LA G + +V +++S L+ R T LH+A+ +GH +V+VLL G +++
Sbjct: 164 PLDLAALYGRLRVVKMIISAHPNLMSCNTRK-HTPLHLAARNGHKAVVQVLLEAGMDVSC 222
Query: 1342 TDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNL 1378
+ G + LH AA G ++VV++L E+G + +L
Sbjct: 223 QTEKG-SALHEAALFGKVDVVRVLLETGIDANIKDSL 258
Score = 91.1 bits (216), Expect = 4e-17
Identities = 60/199 (30%), Positives = 102/199 (51%), Gaps = 6/199 (3%)
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
+N +S G+T L A GH +V LL A +V D +G +HLAA G +++ L
Sbjct: 52 VNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKIL 111
Query: 982 L---TNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAA 1038
+ + + +N + TALH AA G++ +V L+ + + K +TPL LAA
Sbjct: 112 IHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPT-IRNSKLETPLDLAAL 170
Query: 1039 SGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNT 1098
G++ V K+++ N+ + + P+H AA+N + VVQ+ L+ ++ T K +
Sbjct: 171 YGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEK--GS 228
Query: 1099 CAHIAAIQGSVKVIEELMK 1117
H AA+ G V V+ L++
Sbjct: 229 ALHEAALFGKVDVVRVLLE 247
Score = 89.4 bits (212), Expect = 1e-16
Identities = 72/247 (29%), Positives = 114/247 (46%), Gaps = 8/247 (3%)
Query: 940 GHMQLVNTL-LTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTA 998
G + L N L + V+ D G +ALH AA +G+ + LL +A N G
Sbjct: 36 GPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFP 95
Query: 999 LHLAAMNGYAHLVKFLIRD--HNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID 1056
+HLAA G +VK LI ++ ++ + +T LH AA G EV +LLE +
Sbjct: 96 IHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPT 155
Query: 1057 ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
+ + P+ AA VV++ + HPNL+ T+ +T H+AA G V++ L+
Sbjct: 156 IRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRK-HTPLHLAARNGHKAVVQVLL 214
Query: 1117 KFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHG 1176
+ +S + + + L AA G DVVRVL+ G ++ G T + + EH
Sbjct: 215 EAGMD--VSCQTEKGSA--LHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHP 270
Query: 1177 HTNVLDV 1183
L +
Sbjct: 271 SQKSLQI 277
Score = 82.6 bits (195), Expect = 1e-14
Identities = 76/240 (31%), Positives = 118/240 (49%), Gaps = 19/240 (7%)
Query: 1035 LAAASGQIEVCKLL-LELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT 1093
L SG + + LL + G N++ TD G +H AA N + ++V LQ + +A
Sbjct: 31 LGGGSGPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADN 90
Query: 1094 KDGNTCAHIAAIQGSVKVIEELMKFDRT-GVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
K G H+AA +G V++++ L+ + ++ +N N+ T L AA+ GH++VV VL+
Sbjct: 91 K-GYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENE-TALHCAAQYGHSEVVAVLL 148
Query: 1153 RAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAE 1212
T N T + LAA +G V+ ++ S + +S TPLH+AA G
Sbjct: 149 EELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKA 208
Query: 1213 TVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
V+ LL EA VS E G + LH AA G +VVR+LL + G+ A+
Sbjct: 209 VVQVLL---------EAGMDVS----CQTEKG-SALHEAALFGKVDVVRVLLET-GIDAN 253
Score = 81.8 bits (193), Expect = 2e-14
Identities = 54/164 (32%), Positives = 83/164 (50%), Gaps = 4/164 (2%)
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR- 1301
SG T LH AA NG++++V LL + A N+ GY P+HLA + G + IV +L+
Sbjct: 58 SGYTALHHAALNGHKDIVLKLLQYEA-STNVADNK-GYFPIHLAAWKGDVEIVKILIHHG 115
Query: 1302 -SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLN 1360
S ++ + +T LH A+ +GH ++V VLL + + + TPL AA G L
Sbjct: 116 PSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLR 175
Query: 1361 VVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
VVK++ + + S P+ AA H V++ LL D
Sbjct: 176 VVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMD 219
Score = 81.4 bits (192), Expect = 3e-14
Identities = 70/226 (30%), Positives = 109/226 (48%), Gaps = 24/226 (10%)
Query: 1178 TNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVP 1237
+N+L + R N S G T LH AA G + V +LL + EA T V+
Sbjct: 41 SNLLSIWRGPNVNCTDSS--GYTALHHAALNGHKDIVLKLLQY-------EASTNVA--- 88
Query: 1238 VLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNP--LHLACFGGHMSIV 1295
G P+HLAA+ G+ +V++L++ G + +N N LH A GH +V
Sbjct: 89 ---DNKGYFPIHLAAWKGDVEIVKILIHH-GPSHSRVNEQNNENETALHCAAQYGHSEVV 144
Query: 1296 GLLLSRSAELLHSTDRHGK--TGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCA 1353
+LL EL T R+ K T L +A+ +G ++V++++ + + + TPLH A
Sbjct: 145 AVLLE---ELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLA 201
Query: 1354 AKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
A+ GH VV++L E+G +T A + AA DV+ LL
Sbjct: 202 ARNGHKAVVQVLLEAGMDVSCQTEKGSA-LHEAALFGKVDVVRVLL 246
Score = 77.8 bits (183), Expect = 4e-13
Identities = 67/220 (30%), Positives = 100/220 (45%), Gaps = 20/220 (9%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM--RSTNTLR 1191
T L AA GH D+V L++ AS + G +HLAA G ++ ++ + R
Sbjct: 61 TALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSR 120
Query: 1192 ISSKKL-GLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHL 1250
++ + T LH AA YG +E V LL + P + TPL L
Sbjct: 121 VNEQNNENETALHCAAQYGHSEVVAVLLEELTD-------------PTIRNSKLETPLDL 167
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
AA G VV++++ SA + N + PLHLA GH ++V +LL ++ T+
Sbjct: 168 AALYGRLRVVKMII-SAHPNL-MSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTE 225
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPL 1350
+ + LH A+ G +V VLL G + N D G T L
Sbjct: 226 KG--SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVL 263
Score = 70.1 bits (164), Expect = 8e-11
Identities = 46/162 (28%), Positives = 79/162 (48%), Gaps = 3/162 (1%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLS-AQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
+G P+ LA G+ +V+ L+ + ++ +TALH AA+ ++ +L++
Sbjct: 91 KGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEE 150
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
N +TPL +AA G +VK N + TP+HLAA NGH A++
Sbjct: 151 LTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVV 210
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGV 222
++L + + +T+ GS L H A+L G D +L + G+
Sbjct: 211 QVLLEA-GMDVSCQTEKGSAL-HEAALFGKVDVVRVLLETGI 250
Score = 69.3 bits (162), Expect = 1e-10
Identities = 63/242 (26%), Positives = 115/242 (47%), Gaps = 17/242 (7%)
Query: 840 IDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAI 899
++ D G +ALH+A + +V L++ A ++ + H A
Sbjct: 52 VNCTDSSGYTALHHAAL---------NGHKDIVLKLLQYEASTNVADNKGY-FPIHLAAW 101
Query: 900 AGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFD 959
G+ +++ +I H + SR +N QN+ T L A GH ++V LL + +
Sbjct: 102 KGDVEIVKILIHHGPSH--SR-VNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRN 158
Query: 960 VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHN 1019
+ + L LAA +G L+V +++ + S T LHLAA NG+ +V+ L+
Sbjct: 159 SKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLE--- 215
Query: 1020 AMIDV-LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVV 1078
A +DV +K + LH AA G+++V ++LLE G + + D LG+ + ++ + +
Sbjct: 216 AGMDVSCQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSL 275
Query: 1079 QL 1080
Q+
Sbjct: 276 QI 277
Score = 60.5 bits (140), Expect = 6e-08
Identities = 49/187 (26%), Positives = 83/187 (44%), Gaps = 11/187 (5%)
Query: 82 LLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAE 141
LLS + T +G TALH AA D+ L+ Y A + + G P+H+AA +
Sbjct: 43 LLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWK 102
Query: 142 GDEPLVKYF--YG-VRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKASIFERTKDG 198
GD +VK +G + +NE+ T +H AA+ GH+ ++ +L ++ +K
Sbjct: 103 GDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSK-L 161
Query: 199 STLMHIASLNGHADCAMMLFKKGVYL-------HMPNKYFEKQTFDEVLFVKIENGLIKG 251
T + +A+L G M+ L H P + V+ V +E G+
Sbjct: 162 ETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVS 221
Query: 252 LKSDDGS 258
+++ GS
Sbjct: 222 CQTEKGS 228
Score = 59.7 bits (138), Expect = 1e-07
Identities = 38/118 (32%), Positives = 56/118 (47%), Gaps = 3/118 (2%)
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP 1349
G + + LL ++ TD G T LH A+ +GH +V LL A N D G+ P
Sbjct: 36 GPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFP 95
Query: 1350 LHCAAKAGHLNVVKLLCESGAS---PKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
+H AA G + +VK+L G S + N N + AA H++V+ LL + D
Sbjct: 96 IHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTD 153
Score = 57.6 bits (133), Expect = 4e-07
Identities = 67/255 (26%), Positives = 117/255 (45%), Gaps = 34/255 (13%)
Query: 674 GHVGIINTL-LQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRET 732
G + + N L + +G +V+ T + YTALH A + +V LL Y A ++ K
Sbjct: 36 GPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNK-GYF 94
Query: 733 PLHIAARIPDGDKCALMLL--KSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDP 790
P+H+AA D + +++ S + N+ + T +H AA++G+ + +LLE+ DP
Sbjct: 95 PIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDP 154
Query: 791 -LRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGAS 849
+R +K+ ETPL +A +V+ +I H + + + +
Sbjct: 155 TIRNSKL--------ETPLDLAALYGRLRVVKMII---SAHPN-------LMSCNTRKHT 196
Query: 850 ALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEM 909
LH A + + VV+ L+E G DVS QT +A H A+ G DV+ +
Sbjct: 197 PLHLAAR---------NGHKAVVQVLLEAGMDVSCQTEKG--SALHEAALFGKVDVVRVL 245
Query: 910 IAHISTADVSRALNR 924
+ A++ +L R
Sbjct: 246 LETGIDANIKDSLGR 260
Score = 56.8 bits (131), Expect = 8e-07
Identities = 45/126 (35%), Positives = 62/126 (49%), Gaps = 5/126 (3%)
Query: 667 IHTAARYGHVGIINTLLQKGES---VDVTTNDNYTALHIAVESCKPAVVETLLGYGADVH 723
IH AA G V I+ L+ G S V+ N+N TALH A + VV LL D
Sbjct: 96 IHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPT 155
Query: 724 IRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLL 783
IR K ETPL +AA + + M++ + TP+H+AA+ G+ A + +L
Sbjct: 156 IRNSKL-ETPLDLAA-LYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVL 213
Query: 784 LEDGGD 789
LE G D
Sbjct: 214 LEAGMD 219
Score = 56.0 bits (129), Expect = 1e-06
Identities = 56/217 (25%), Positives = 106/217 (48%), Gaps = 17/217 (7%)
Query: 666 SIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
++H AA+YGH ++ LL++ + + T L +A + VV+ ++ ++ +
Sbjct: 131 ALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNL-MS 189
Query: 726 GGKQRETPLHIAARIPDGDKCAL-MLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLL 784
++ TPLH+AAR +G K + +LL++G + TE G + +H AA FG + + +LL
Sbjct: 190 CNTRKHTPLHLAAR--NGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLL 246
Query: 785 EDGGDPLRKTKV--CIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDA 842
E G D K + + D++ E P Q + + + +++ +E V + +T +
Sbjct: 247 ETGIDANIKDSLGRTVLDILK-EHPSQKSLQ--IATLLQEYLEGVGKY-----ATVLEEP 298
Query: 843 VDEDGASALHYACKV--TKEEVKIPTADRQVVKCLIE 877
V ED H + V ++ K T ++ K L E
Sbjct: 299 VQEDATQETHISSPVESPSQKTKSETVTGELSKLLDE 335
Score = 52.8 bits (121), Expect = 1e-05
Identities = 38/125 (30%), Positives = 60/125 (48%), Gaps = 5/125 (4%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H AA GH I+ LLQ S +V N Y +H+A +V+ L+ +G
Sbjct: 59 GYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPS- 117
Query: 723 HIRGGKQ---RETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLAT 779
H R +Q ET LH AA+ + A +LL+ P TP+ +AA +G L
Sbjct: 118 HSRVNEQNNENETALHCAAQYGHSEVVA-VLLEELTDPTIRNSKLETPLDLAALYGRLRV 176
Query: 780 LVLLL 784
+ +++
Sbjct: 177 VKMII 181
Score = 36.3 bits (80), Expect = 1.2
Identities = 26/76 (34%), Positives = 40/76 (52%), Gaps = 3/76 (3%)
Query: 62 RGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
R PL LA G++++V+ LL A + T G +ALH AA VD+ R+L++ G
Sbjct: 193 RKHTPLHLAARNGHKAVVQVLLEA--GMDVSCQTEKG-SALHEAALFGKVDVVRVLLETG 249
Query: 122 AVVDATNGAGQTPLHI 137
+ + G+T L I
Sbjct: 250 IDANIKDSLGRTVLDI 265
>BC101620-1|AAI01621.1| 1001|Homo sapiens ankyrin repeat domain 35
protein.
Length = 1001
Score = 94.3 bits (224), Expect = 4e-18
Identities = 65/185 (35%), Positives = 94/185 (50%), Gaps = 3/185 (1%)
Query: 933 LLIACHRGHMQLVNTLLTNH-ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSK 991
LL A HRG + V L + AR D G+S HLAA G + LL N A INSK
Sbjct: 24 LLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSK 83
Query: 992 ARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLEL 1051
+G TALHLA ++ VK L++ H A D + + ++PLH AA+SG LL +
Sbjct: 84 NEDGSTALHLATISCQPQCVKVLLQ-HGANEDAVDAENRSPLHWAASSGCASSVLLLCDH 142
Query: 1052 GANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKV 1111
A +D D G+ P+ A+ ++ + LQ+ V T K+ + +A +GS +V
Sbjct: 143 EAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGAR-VNVTDKNDKSALILACEKGSAEV 201
Query: 1112 IEELM 1116
E L+
Sbjct: 202 AELLL 206
Score = 84.2 bits (199), Expect = 4e-15
Identities = 56/178 (31%), Positives = 88/178 (49%), Gaps = 2/178 (1%)
Query: 926 NSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNK 985
+S G +P +A +G + + LL N A ++ + +G +ALHLA Q LL +
Sbjct: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
Query: 986 AFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVC 1045
A ++ R+ LH AA +G A V L+ DH A +DVL +TPL +A+ G +C
Sbjct: 111 ANEDAVDAENRSPLHWAASSGCASSV-LLLCDHEAFLDVLDNDGRTPLMIASLGGHAAIC 169
Query: 1046 KLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIA 1103
LL+ GA ++ TD+ + + A + +EV +L L H A G+ H A
Sbjct: 170 SQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL-SHGADAGAVDSTGHDALHYA 226
Score = 83.8 bits (198), Expect = 6e-15
Identities = 59/181 (32%), Positives = 89/181 (49%), Gaps = 7/181 (3%)
Query: 889 NHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTL 948
N ++ FH A G + +T ++A+ AD+ N +N G T L +A Q V L
Sbjct: 53 NGQSPFHLAASKGLTECLTILLAN--GADI----NSKNEDGSTALHLATISCQPQCVKVL 106
Query: 949 LTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYA 1008
L + A D D E RS LH AA G L ++AF++ +GRT L +A++ G+A
Sbjct: 107 LQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHA 166
Query: 1009 HLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHA 1068
+ L++ A ++V ++ L LA G EV +LLL GA+ A D G +H
Sbjct: 167 AICSQLLQ-RGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHY 225
Query: 1069 A 1069
A
Sbjct: 226 A 226
Score = 81.4 bits (192), Expect = 3e-14
Identities = 72/242 (29%), Positives = 107/242 (44%), Gaps = 16/242 (6%)
Query: 1112 IEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHL 1171
++ + T V R +D L+ G V + R A T + G + HL
Sbjct: 1 MKRIFSCSSTQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHL 60
Query: 1172 AAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT 1231
AA G T L ++ + S + G T LH+A Q + V+ LL H
Sbjct: 61 AASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQH----------- 109
Query: 1232 GVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGH 1291
G + + AE+ +PLH AA +G + V LL + D N+ G PL +A GGH
Sbjct: 110 GAN-EDAVDAENR-SPLHWAASSGCASSVLLLCDHEAF-LDVLDND-GRTPLMIASLGGH 165
Query: 1292 MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLH 1351
+I LL R A + + TD++ K+ L +A G ++ E+LL GA+ A D G LH
Sbjct: 166 AAICSQLLQRGARV-NVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALH 224
Query: 1352 CA 1353
A
Sbjct: 225 YA 226
Score = 81.0 bits (191), Expect = 4e-14
Identities = 55/163 (33%), Positives = 82/163 (50%), Gaps = 2/163 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
LL AV G+ V L S ++A K + G + HLAA + + IL+ GA +++
Sbjct: 24 LLEAVHRGDVGRVAALASRKSARPTKLDSN-GQSPFHLAASKGLTECLTILLANGADINS 82
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
N G T LH+A VK AN D E+R+P+H AA +G A+ + LL D
Sbjct: 83 KNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDH 142
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+A + DG T + IASL GHA L ++G +++ +K
Sbjct: 143 -EAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDK 184
Score = 77.8 bits (183), Expect = 4e-13
Identities = 70/205 (34%), Positives = 92/205 (44%), Gaps = 19/205 (9%)
Query: 1166 LTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTV 1225
L AVH + G L +S ++ S G +P H+AA G E + LL++ +
Sbjct: 25 LEAVH-RGDVGRVAALASRKSARPTKLDSN--GQSPFHLAASKGLTECLTILLAN-GADI 80
Query: 1226 KSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHL 1285
S+ E G T LHLA + V++LL G DA EN +PLH
Sbjct: 81 NSKN------------EDGSTALHLATISCQPQCVKVLLQH-GANEDAVDAENR-SPLHW 126
Query: 1286 ACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKN 1345
A G S V LL A L D G+T L IAS GH + LL +GA +N TDKN
Sbjct: 127 AASSGCASSVLLLCDHEA-FLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKN 185
Query: 1346 GWTPLHCAAKAGHLNVVKLLCESGA 1370
+ L A + G V +LL GA
Sbjct: 186 DKSALILACEKGSAEVAELLLSHGA 210
Score = 68.5 bits (160), Expect = 2e-10
Identities = 42/126 (33%), Positives = 63/126 (50%), Gaps = 1/126 (0%)
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQ 1335
+ NG +P HLA G + +LL+ A++ +S + G T LH+A+ Q V+VLL
Sbjct: 51 DSNGQSPFHLAASKGLTECLTILLANGADI-NSKNEDGSTALHLATISCQPQCVKVLLQH 109
Query: 1336 GAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVL 1395
GA +A D +PLH AA +G + V LLC+ A N P+ A+ H +
Sbjct: 110 GANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAIC 169
Query: 1396 EYLLHK 1401
LL +
Sbjct: 170 SQLLQR 175
Score = 67.7 bits (158), Expect = 4e-10
Identities = 47/159 (29%), Positives = 73/159 (45%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ P LA G + LL+ + + G TALHLA ++L+ +GA
Sbjct: 54 GQSPFHLAASKGLTECLTILLA--NGADINSKNEDGSTALHLATISCQPQCVKVLLQHGA 111
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
DA + ++PLH AA+ G V A + DN+ RTP+ +A+ GHAAI
Sbjct: 112 NEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQ 171
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L + A + K+ + + +A G A+ A +L G
Sbjct: 172 LLQR-GARVNVTDKNDKSALILACEKGSAEVAELLLSHG 209
Score = 67.3 bits (157), Expect = 6e-10
Identities = 50/178 (28%), Positives = 83/178 (46%), Gaps = 4/178 (2%)
Query: 1030 QTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
Q+P HLAA+ G E +LL GA+I++ +E G +H A + + V++ LQ N
Sbjct: 55 QSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGAN-E 113
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVR 1149
A + + H AA G + L+ D + + + TPL +A+ GGHA +
Sbjct: 114 DAVDAENRSPLHWAASSGCASSV--LLLCDHEAFLDVLDN-DGRTPLMIASLGGHAAICS 170
Query: 1150 VLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAY 1207
L++ GA ++ +A+ LA E G V +++ S + G LH A +
Sbjct: 171 QLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALH 228
Score = 64.5 bits (150), Expect = 4e-09
Identities = 53/165 (32%), Positives = 81/165 (49%), Gaps = 16/165 (9%)
Query: 838 AFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYC 897
A I++ +EDG++ALH A + Q VK L+++GA+ N + H+
Sbjct: 78 ADINSKNEDGSTALHLATI---------SCQPQCVKVLLQHGANEDAVDAENR-SPLHWA 127
Query: 898 AIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
A +G + + H + DV ++ G TPL+IA GH + + LL ARV+V
Sbjct: 128 ASSGCASSVLLLCDHEAFLDVL------DNDGRTPLMIASLGGHAAICSQLLQRGARVNV 181
Query: 958 FDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLA 1002
D +SAL LA E G +V + LL++ A + G ALH A
Sbjct: 182 TDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYA 226
Score = 63.3 bits (147), Expect = 9e-09
Identities = 57/193 (29%), Positives = 85/193 (44%), Gaps = 19/193 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G H AA G + LL G ++ D TALH+A SC+P V+ LL +GA+
Sbjct: 53 NGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGAN 112
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ R +PLH AA L+L A + DG TP+ +A+ G+ A
Sbjct: 113 EDAVDAENR-SPLHWAASSGCASS-VLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICS 170
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LL+ G +V + D ++ L +AC ++ E + H ++
Sbjct: 171 QLLQRG------ARVNVTD-KNDKSALILACEKGSAEVA----ELLLSHGADA------G 213
Query: 842 AVDEDGASALHYA 854
AVD G ALHYA
Sbjct: 214 AVDSTGHDALHYA 226
Score = 61.3 bits (142), Expect = 4e-08
Identities = 47/158 (29%), Positives = 71/158 (44%), Gaps = 5/158 (3%)
Query: 1243 SGLTPLHLAAYNG-NENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+G +P HLAA G E + LL N A + + NE+G LHLA V +LL
Sbjct: 53 NGQSPFHLAASKGLTECLTILLANGADINS---KNEDGSTALHLATISCQPQCVKVLLQH 109
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNV 1361
A + D ++ LH A++ G V +L A ++ D +G TPL A+ GH +
Sbjct: 110 GANE-DAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAI 168
Query: 1362 VKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
L + GA + + + A + +V E LL
Sbjct: 169 CSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
Score = 56.4 bits (130), Expect = 1e-06
Identities = 53/228 (23%), Positives = 95/228 (41%), Gaps = 33/228 (14%)
Query: 742 DGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDV 801
D + A + + A P K +G +P H+AA G L +LL +G D K +
Sbjct: 32 DVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNE------ 85
Query: 802 VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEE 861
G T L +A SC P V+ L++ H DAVD + S LH+A
Sbjct: 86 -DGSTALHLATISCQPQCVKVLLQ----HGANE------DAVDAENRSPLHWAASSGCAS 134
Query: 862 VKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRA 921
+ D + +++N + T ++ G+ + ++++ + +V+
Sbjct: 135 SVLLLCDHEAFLDVLDN----------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDK 184
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
++ + L++AC +G ++ LL++ A D G ALH A
Sbjct: 185 NDK------SALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYA 226
Score = 55.6 bits (128), Expect = 2e-06
Identities = 31/99 (31%), Positives = 55/99 (55%)
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP 1349
G + V L SR + D +G++ H+A++ G + + +LL GA+IN+ +++G T
Sbjct: 31 GDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTA 90
Query: 1350 LHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAAS 1388
LH A + VK+L + GA+ + N +P+ +AAS
Sbjct: 91 LHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAAS 129
Score = 43.6 bits (98), Expect = 0.008
Identities = 37/131 (28%), Positives = 59/131 (45%), Gaps = 2/131 (1%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ DG+ ++H A + LLQ G + D +N + LH A S + V L +
Sbjct: 83 KNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDH 142
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
A + + R TPL IA+ C+ LL+ GA N ++ + + +A + G+
Sbjct: 143 EAFLDVLDNDGR-TPLMIASLGGHAAICS-QLLQRGARVNVTDKNDKSALILACEKGSAE 200
Query: 779 TLVLLLEDGGD 789
LLL G D
Sbjct: 201 VAELLLSHGAD 211
Score = 43.2 bits (97), Expect = 0.010
Identities = 25/93 (26%), Positives = 47/93 (50%), Gaps = 2/93 (2%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D++ G+ PL++A G+ ++ +LL Q ++ T +AL LA + ++A +
Sbjct: 147 DVLDNDGRTPLMIASLGGHAAICSQLL--QRGARVNVTDKNDKSALILACEKGSAEVAEL 204
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKY 149
L+ +GA A + G LH A D+ L ++
Sbjct: 205 LLSHGADAGAVDSTGHDALHYALHTQDKALWRH 237
>BC101618-1|AAI01619.1| 1001|Homo sapiens ankyrin repeat domain 35
protein.
Length = 1001
Score = 94.3 bits (224), Expect = 4e-18
Identities = 65/185 (35%), Positives = 94/185 (50%), Gaps = 3/185 (1%)
Query: 933 LLIACHRGHMQLVNTLLTNH-ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSK 991
LL A HRG + V L + AR D G+S HLAA G + LL N A INSK
Sbjct: 24 LLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSK 83
Query: 992 ARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLEL 1051
+G TALHLA ++ VK L++ H A D + + ++PLH AA+SG LL +
Sbjct: 84 NEDGSTALHLATISCQPQCVKVLLQ-HGANEDAVDAENRSPLHWAASSGCASSVLLLCDH 142
Query: 1052 GANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKV 1111
A +D D G+ P+ A+ ++ + LQ+ V T K+ + +A +GS +V
Sbjct: 143 EAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGAR-VNVTDKNDKSALILACEKGSAEV 201
Query: 1112 IEELM 1116
E L+
Sbjct: 202 AELLL 206
Score = 84.2 bits (199), Expect = 4e-15
Identities = 56/178 (31%), Positives = 88/178 (49%), Gaps = 2/178 (1%)
Query: 926 NSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNK 985
+S G +P +A +G + + LL N A ++ + +G +ALHLA Q LL +
Sbjct: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
Query: 986 AFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVC 1045
A ++ R+ LH AA +G A V L+ DH A +DVL +TPL +A+ G +C
Sbjct: 111 ANEDAVDAENRSPLHWAASSGCASSV-LLLCDHEAFLDVLDNDGRTPLMIASLGGHAAIC 169
Query: 1046 KLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIA 1103
LL+ GA ++ TD+ + + A + +EV +L L H A G+ H A
Sbjct: 170 SQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL-SHGADAGAVDSTGHDALHYA 226
Score = 83.8 bits (198), Expect = 6e-15
Identities = 59/181 (32%), Positives = 89/181 (49%), Gaps = 7/181 (3%)
Query: 889 NHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTL 948
N ++ FH A G + +T ++A+ AD+ N +N G T L +A Q V L
Sbjct: 53 NGQSPFHLAASKGLTECLTILLAN--GADI----NSKNEDGSTALHLATISCQPQCVKVL 106
Query: 949 LTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYA 1008
L + A D D E RS LH AA G L ++AF++ +GRT L +A++ G+A
Sbjct: 107 LQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHA 166
Query: 1009 HLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHA 1068
+ L++ A ++V ++ L LA G EV +LLL GA+ A D G +H
Sbjct: 167 AICSQLLQ-RGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHY 225
Query: 1069 A 1069
A
Sbjct: 226 A 226
Score = 81.4 bits (192), Expect = 3e-14
Identities = 72/242 (29%), Positives = 107/242 (44%), Gaps = 16/242 (6%)
Query: 1112 IEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHL 1171
++ + T V R +D L+ G V + R A T + G + HL
Sbjct: 1 MKRIFSCSSTQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHL 60
Query: 1172 AAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT 1231
AA G T L ++ + S + G T LH+A Q + V+ LL H
Sbjct: 61 AASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQH----------- 109
Query: 1232 GVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGH 1291
G + + AE+ +PLH AA +G + V LL + D N+ G PL +A GGH
Sbjct: 110 GAN-EDAVDAENR-SPLHWAASSGCASSVLLLCDHEAF-LDVLDND-GRTPLMIASLGGH 165
Query: 1292 MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLH 1351
+I LL R A + + TD++ K+ L +A G ++ E+LL GA+ A D G LH
Sbjct: 166 AAICSQLLQRGARV-NVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALH 224
Query: 1352 CA 1353
A
Sbjct: 225 YA 226
Score = 81.0 bits (191), Expect = 4e-14
Identities = 55/163 (33%), Positives = 82/163 (50%), Gaps = 2/163 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
LL AV G+ V L S ++A K + G + HLAA + + IL+ GA +++
Sbjct: 24 LLEAVHRGDVGRVAALASRKSARPTKLDSN-GQSPFHLAASKGLTECLTILLANGADINS 82
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
N G T LH+A VK AN D E+R+P+H AA +G A+ + LL D
Sbjct: 83 KNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDH 142
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+A + DG T + IASL GHA L ++G +++ +K
Sbjct: 143 -EAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDK 184
Score = 77.8 bits (183), Expect = 4e-13
Identities = 70/205 (34%), Positives = 92/205 (44%), Gaps = 19/205 (9%)
Query: 1166 LTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTV 1225
L AVH + G L +S ++ S G +P H+AA G E + LL++ +
Sbjct: 25 LEAVH-RGDVGRVAALASRKSARPTKLDSN--GQSPFHLAASKGLTECLTILLAN-GADI 80
Query: 1226 KSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHL 1285
S+ E G T LHLA + V++LL G DA EN +PLH
Sbjct: 81 NSKN------------EDGSTALHLATISCQPQCVKVLLQH-GANEDAVDAENR-SPLHW 126
Query: 1286 ACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKN 1345
A G S V LL A L D G+T L IAS GH + LL +GA +N TDKN
Sbjct: 127 AASSGCASSVLLLCDHEA-FLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKN 185
Query: 1346 GWTPLHCAAKAGHLNVVKLLCESGA 1370
+ L A + G V +LL GA
Sbjct: 186 DKSALILACEKGSAEVAELLLSHGA 210
Score = 68.5 bits (160), Expect = 2e-10
Identities = 42/126 (33%), Positives = 63/126 (50%), Gaps = 1/126 (0%)
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQ 1335
+ NG +P HLA G + +LL+ A++ +S + G T LH+A+ Q V+VLL
Sbjct: 51 DSNGQSPFHLAASKGLTECLTILLANGADI-NSKNEDGSTALHLATISCQPQCVKVLLQH 109
Query: 1336 GAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVL 1395
GA +A D +PLH AA +G + V LLC+ A N P+ A+ H +
Sbjct: 110 GANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAIC 169
Query: 1396 EYLLHK 1401
LL +
Sbjct: 170 SQLLQR 175
Score = 67.7 bits (158), Expect = 4e-10
Identities = 47/159 (29%), Positives = 73/159 (45%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ P LA G + LL+ + + G TALHLA ++L+ +GA
Sbjct: 54 GQSPFHLAASKGLTECLTILLA--NGADINSKNEDGSTALHLATISCQPQCVKVLLQHGA 111
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
DA + ++PLH AA+ G V A + DN+ RTP+ +A+ GHAAI
Sbjct: 112 NEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQ 171
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L + A + K+ + + +A G A+ A +L G
Sbjct: 172 LLQR-GARVNVTDKNDKSALILACEKGSAEVAELLLSHG 209
Score = 67.3 bits (157), Expect = 6e-10
Identities = 50/178 (28%), Positives = 83/178 (46%), Gaps = 4/178 (2%)
Query: 1030 QTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
Q+P HLAA+ G E +LL GA+I++ +E G +H A + + V++ LQ N
Sbjct: 55 QSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGAN-E 113
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVR 1149
A + + H AA G + L+ D + + + TPL +A+ GGHA +
Sbjct: 114 DAVDAENRSPLHWAASSGCASSV--LLLCDHEAFLDVLDN-DGRTPLMIASLGGHAAICS 170
Query: 1150 VLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAY 1207
L++ GA ++ +A+ LA E G V +++ S + G LH A +
Sbjct: 171 QLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALH 228
Score = 64.5 bits (150), Expect = 4e-09
Identities = 53/165 (32%), Positives = 81/165 (49%), Gaps = 16/165 (9%)
Query: 838 AFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYC 897
A I++ +EDG++ALH A + Q VK L+++GA+ N + H+
Sbjct: 78 ADINSKNEDGSTALHLATI---------SCQPQCVKVLLQHGANEDAVDAENR-SPLHWA 127
Query: 898 AIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
A +G + + H + DV ++ G TPL+IA GH + + LL ARV+V
Sbjct: 128 ASSGCASSVLLLCDHEAFLDVL------DNDGRTPLMIASLGGHAAICSQLLQRGARVNV 181
Query: 958 FDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLA 1002
D +SAL LA E G +V + LL++ A + G ALH A
Sbjct: 182 TDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYA 226
Score = 63.3 bits (147), Expect = 9e-09
Identities = 57/193 (29%), Positives = 85/193 (44%), Gaps = 19/193 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G H AA G + LL G ++ D TALH+A SC+P V+ LL +GA+
Sbjct: 53 NGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGAN 112
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ R +PLH AA L+L A + DG TP+ +A+ G+ A
Sbjct: 113 EDAVDAENR-SPLHWAASSGCASS-VLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICS 170
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LL+ G +V + D ++ L +AC ++ E + H ++
Sbjct: 171 QLLQRG------ARVNVTD-KNDKSALILACEKGSAEVA----ELLLSHGADA------G 213
Query: 842 AVDEDGASALHYA 854
AVD G ALHYA
Sbjct: 214 AVDSTGHDALHYA 226
Score = 61.3 bits (142), Expect = 4e-08
Identities = 47/158 (29%), Positives = 71/158 (44%), Gaps = 5/158 (3%)
Query: 1243 SGLTPLHLAAYNG-NENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+G +P HLAA G E + LL N A + + NE+G LHLA V +LL
Sbjct: 53 NGQSPFHLAASKGLTECLTILLANGADINS---KNEDGSTALHLATISCQPQCVKVLLQH 109
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNV 1361
A + D ++ LH A++ G V +L A ++ D +G TPL A+ GH +
Sbjct: 110 GANE-DAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAI 168
Query: 1362 VKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
L + GA + + + A + +V E LL
Sbjct: 169 CSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLL 206
Score = 56.4 bits (130), Expect = 1e-06
Identities = 53/228 (23%), Positives = 95/228 (41%), Gaps = 33/228 (14%)
Query: 742 DGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDV 801
D + A + + A P K +G +P H+AA G L +LL +G D K +
Sbjct: 32 DVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNE------ 85
Query: 802 VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEE 861
G T L +A SC P V+ L++ H DAVD + S LH+A
Sbjct: 86 -DGSTALHLATISCQPQCVKVLLQ----HGANE------DAVDAENRSPLHWAASSGCAS 134
Query: 862 VKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRA 921
+ D + +++N + T ++ G+ + ++++ + +V+
Sbjct: 135 SVLLLCDHEAFLDVLDN----------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDK 184
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
++ + L++AC +G ++ LL++ A D G ALH A
Sbjct: 185 NDK------SALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYA 226
Score = 55.6 bits (128), Expect = 2e-06
Identities = 31/99 (31%), Positives = 55/99 (55%)
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP 1349
G + V L SR + D +G++ H+A++ G + + +LL GA+IN+ +++G T
Sbjct: 31 GDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTA 90
Query: 1350 LHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAAS 1388
LH A + VK+L + GA+ + N +P+ +AAS
Sbjct: 91 LHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAAS 129
Score = 43.6 bits (98), Expect = 0.008
Identities = 37/131 (28%), Positives = 59/131 (45%), Gaps = 2/131 (1%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ DG+ ++H A + LLQ G + D +N + LH A S + V L +
Sbjct: 83 KNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDH 142
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
A + + R TPL IA+ C+ LL+ GA N ++ + + +A + G+
Sbjct: 143 EAFLDVLDNDGR-TPLMIASLGGHAAICS-QLLQRGARVNVTDKNDKSALILACEKGSAE 200
Query: 779 TLVLLLEDGGD 789
LLL G D
Sbjct: 201 VAELLLSHGAD 211
Score = 43.2 bits (97), Expect = 0.010
Identities = 25/93 (26%), Positives = 47/93 (50%), Gaps = 2/93 (2%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D++ G+ PL++A G+ ++ +LL Q ++ T +AL LA + ++A +
Sbjct: 147 DVLDNDGRTPLMIASLGGHAAICSQLL--QRGARVNVTDKNDKSALILACEKGSAEVAEL 204
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKY 149
L+ +GA A + G LH A D+ L ++
Sbjct: 205 LLSHGADAGAVDSTGHDALHYALHTQDKALWRH 237
>AK001283-1|BAA91599.1| 445|Homo sapiens protein ( Homo sapiens cDNA
FLJ10421 fis, clone NT2RP1000202, weakly similar to
ANKYRIN. ).
Length = 445
Score = 94.3 bits (224), Expect = 4e-18
Identities = 68/233 (29%), Positives = 121/233 (51%), Gaps = 12/233 (5%)
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLE 1050
K G ALHLAA G+ +V+ L+ + A + TL++ TPL A +GQI+V +LLL+
Sbjct: 2 KTFEGFCALHLAASQGHWKIVQILL-EAGADPNATTLEETTPLFSAVENGQIDVLRLLLQ 60
Query: 1051 LGANIDATDEL-GQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSV 1109
GAN++ + + G +H A+ +E+++L L++ N G T +AA G +
Sbjct: 61 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGAN-KECQDDFGITPLFVAAQYGKL 119
Query: 1110 KVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGAS----CTDENRAG 1165
+ + L+ +G L+ +TPL +AA+ GH V +L+ +GA C ++ +
Sbjct: 120 ESLSILIS---SGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNED--SW 174
Query: 1166 LTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELL 1218
+H AA+ GHT +LD++ + ++P++ A + G + + LL
Sbjct: 175 QLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 227
Score = 86.6 bits (205), Expect = 8e-16
Identities = 66/231 (28%), Positives = 111/231 (48%), Gaps = 6/231 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G+ L +A +GH ++V LL A + +E + L A E+G + V LL + A +
Sbjct: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFSAVENGQIDVLRLLLQHGANV 65
Query: 989 N-SKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKL 1047
N S + G +LH A+ A ++K L+R A + TPL +AA G++E +
Sbjct: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLR-KGANKECQDDFGITPLFVAAQYGKLESLSI 124
Query: 1048 LLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDG-NTCAHIAAIQ 1106
L+ GAN++ P+ AAQ +++ V+L L + + +D H AA
Sbjct: 125 LISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQM 184
Query: 1107 GSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGAS 1157
G K+++ L+ + NK+ +P+ A GGH D + +L+R G S
Sbjct: 185 GHTKILDLLIPLTNRACDTGLNKV---SPVYSAVFGGHEDCLEILLRNGYS 232
Score = 85.8 bits (203), Expect = 1e-15
Identities = 55/156 (35%), Positives = 79/156 (50%), Gaps = 4/156 (2%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
TPL A NG +V+RLLL G + + + G+N LH A F + I+ LLL + A
Sbjct: 41 TPLFSAVENGQIDVLRLLLQH-GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANK 99
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
D G T L +A+ +G + + +L+ GA +N + TPL AA+ GH V+LL
Sbjct: 100 -ECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELL 158
Query: 1366 CESGASPKSETNLNC--APIWFAASENHNDVLEYLL 1399
SGA P N + PI AA H +L+ L+
Sbjct: 159 LSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLI 194
Score = 81.8 bits (193), Expect = 2e-14
Identities = 54/161 (33%), Positives = 79/161 (49%), Gaps = 2/161 (1%)
Query: 1244 GLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSA 1303
G LHLAA G+ +V++LL AG +A + E PL A G + ++ LLL A
Sbjct: 6 GFCALHLAASQGHWKIVQILLE-AGADPNATTLEET-TPLFSAVENGQIDVLRLLLQHGA 63
Query: 1304 ELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVK 1363
+ S G LH AS + +++++LL +GA D G TPL AA+ G L +
Sbjct: 64 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLS 123
Query: 1364 LLCESGASPKSETNLNCAPIWFAASENHNDVLEYLLHKEHD 1404
+L SGA+ + P++ AA E H +E LL D
Sbjct: 124 ILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD 164
Score = 81.0 bits (191), Expect = 4e-14
Identities = 63/225 (28%), Positives = 103/225 (45%), Gaps = 4/225 (1%)
Query: 961 EGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
EG ALHLAA G+ ++ LL A N+ T L A NG +++ L++ H A
Sbjct: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFSAVENGQIDVLRLLLQ-HGA 63
Query: 1021 MID-VLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQ 1079
++ ++ LH A+ E+ KLLL GAN + D+ G P+ AAQ E +
Sbjct: 64 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLS 123
Query: 1080 LFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLA 1139
+ + N V D T IAA +G K +E L+ + N+ + P+ A
Sbjct: 124 ILISSGAN-VNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYC-NEDSWQLPIHAA 181
Query: 1140 AEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
A+ GH ++ +L+ D ++ V+ A GH + L+++
Sbjct: 182 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 226
Score = 79.8 bits (188), Expect = 1e-13
Identities = 68/244 (27%), Positives = 126/244 (51%), Gaps = 21/244 (8%)
Query: 1033 LHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMAT 1092
LHLAA+ G ++ ++LLE GA+ +AT P+ +A +N +V++L LQ N+ +
Sbjct: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFSAVENGQIDVLRLLLQHGANVNGSH 69
Query: 1093 TKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+ G H A+ Q + ++I+ L+ R G TPL +AA+ G + + +L+
Sbjct: 70 SMCGWNSLHQASFQENAEIIKLLL---RKGANKECQDDFGITPLFVAAQYGKLESLSILI 126
Query: 1153 RAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT---LRISSKKLGLTPLHIAAYYG 1209
+GA+ + T + +AA+ GHT ++++ S+ L + L P+H AA G
Sbjct: 127 SSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQL-PIHAAAQMG 185
Query: 1210 QAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGV 1269
+ + +LL +P T ++ TG++ V +P++ A + G+E+ + +LL + G
Sbjct: 186 HTK-ILDLL--IPLTNRA-CDTGLNKV---------SPVYSAVFGGHEDCLEILLRN-GY 231
Query: 1270 QADA 1273
DA
Sbjct: 232 SPDA 235
Score = 74.5 bits (175), Expect = 4e-12
Identities = 66/245 (26%), Positives = 113/245 (46%), Gaps = 17/245 (6%)
Query: 1136 LQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNT-LRISS 1194
L LAA GH +V++L+ AGA T + A E+G +VL ++ + S
Sbjct: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFSAVENGQIDVLRLLLQHGANVNGSH 69
Query: 1195 KKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYN 1254
G LH A++ AE ++ LL G K + G+TPL +AA
Sbjct: 70 SMCGWNSLHQASFQENAEIIKLLLRK--GANKE-----------CQDDFGITPLFVAAQY 116
Query: 1255 GNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL-LHSTDRHG 1313
G + +L++S G + + + PL +A GH V LLLS A+ L+ +
Sbjct: 117 GKLESLSILISS-GANVNCQALDKA-TPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSW 174
Query: 1314 KTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPK 1373
+ +H A+ GH +++++L+ T N +P++ A GH + +++L +G SP
Sbjct: 175 QLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPD 234
Query: 1374 SETNL 1378
++ L
Sbjct: 235 AQACL 239
Score = 69.3 bits (162), Expect = 1e-10
Identities = 43/131 (32%), Positives = 69/131 (52%), Gaps = 1/131 (0%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K F+G ++H AA GH I+ LL+ G + TT + T L AVE+ + V+ LL +
Sbjct: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFSAVENGQIDVLRLLLQH 61
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
GA+V+ LH A + + +LL+ GA + G+TP+ VAA++G L
Sbjct: 62 GANVNGSHSMCGWNSLH-QASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 120
Query: 779 TLVLLLEDGGD 789
+L +L+ G +
Sbjct: 121 SLSILISSGAN 131
Score = 59.7 bits (138), Expect = 1e-07
Identities = 45/160 (28%), Positives = 74/160 (46%), Gaps = 4/160 (2%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G L LA G+ +V+ LL A ATT T L A +D+ R+L+ +GA
Sbjct: 6 GFCALHLAASQGHWKIVQILLEA--GADPNATTLEETTPLFSAVENGQIDVLRLLLQHGA 63
Query: 123 VVDATNG-AGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIE 181
V+ ++ G LH A+ + + ++K AN D+ TP+ +AA+ G +
Sbjct: 64 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLS 123
Query: 182 LLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
+L A++ + D +T + IA+ GH C +L G
Sbjct: 124 ILISS-GANVNCQALDKATPLFIAAQEGHTKCVELLLSSG 162
Score = 58.4 bits (135), Expect = 3e-07
Identities = 42/124 (33%), Positives = 64/124 (51%), Gaps = 4/124 (3%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G S+H A+ + II LL+KG + + + T L +A + K + L+ GA+V
Sbjct: 73 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 132
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPN-KATEDG-MTPVHVAAKFGNLATL 780
+ + + TPL IAA+ KC +LL SGA P+ ED P+H AA+ G+ L
Sbjct: 133 NCQ-ALDKATPLFIAAQ-EGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKIL 190
Query: 781 VLLL 784
LL+
Sbjct: 191 DLLI 194
Score = 54.8 bits (126), Expect = 3e-06
Identities = 39/126 (30%), Positives = 61/126 (48%), Gaps = 3/126 (2%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G T L +AA+ ++ IL+ GA V+ TPL IAA EG V+ A+
Sbjct: 106 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADP 165
Query: 158 AIADNED--RTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAM 215
+ NED + P+H AA+ GH I++LL + + + + ++ A GH DC
Sbjct: 166 DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRAC-DTGLNKVSPVYSAVFGGHEDCLE 224
Query: 216 MLFKKG 221
+L + G
Sbjct: 225 ILLRNG 230
Score = 53.2 bits (122), Expect = 1e-05
Identities = 41/146 (28%), Positives = 66/146 (45%), Gaps = 2/146 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL AVE G ++R LL A + + G +LH A+ + + ++ ++L+ GA +
Sbjct: 42 PLFSAVENGQIDVLRLLLQ-HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 100
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ G TPL +AA G + AN + TP+ +AA+ GH +ELL
Sbjct: 101 CQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLS 160
Query: 186 KFKASIFERTKDGSTL-MHIASLNGH 210
+D L +H A+ GH
Sbjct: 161 SGADPDLYCNEDSWQLPIHAAAQMGH 186
Score = 49.2 bits (112), Expect = 2e-04
Identities = 36/125 (28%), Positives = 63/125 (50%), Gaps = 3/125 (2%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTND-NYTALHIAVESCKPAVVETLLGYGADVHIR 725
+ +A G + ++ LLQ G +V+ + + + +LH A +++ LL GA+ +
Sbjct: 43 LFSAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQ 102
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
TPL +AA+ + ++ L+ SGA N D TP+ +AA+ G+ + LLL
Sbjct: 103 DDFGI-TPLFVAAQYGKLESLSI-LISSGANVNCQALDKATPLFIAAQEGHTKCVELLLS 160
Query: 786 DGGDP 790
G DP
Sbjct: 161 SGADP 165
Score = 41.1 bits (92), Expect = 0.041
Identities = 28/116 (24%), Positives = 49/116 (42%)
Query: 131 GQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFKAS 190
G LH+AA++G +V+ A+ E+ TP+ A ENG ++ LL
Sbjct: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFSAVENGQIDVLRLLLQHGANV 65
Query: 191 IFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKYFEKQTFDEVLFVKIEN 246
+ G +H AS +A+ +L +KG + + F + K+E+
Sbjct: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 121
Score = 35.1 bits (77), Expect = 2.7
Identities = 22/64 (34%), Positives = 33/64 (51%), Gaps = 1/64 (1%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
LH+AA K +LL++GA PN T + TP+ A + G + L LLL+ G +
Sbjct: 10 LHLAASQGHW-KIVQILLEAGADPNATTLEETTPLFSAVENGQIDVLRLLLQHGANVNGS 68
Query: 794 TKVC 797
+C
Sbjct: 69 HSMC 72
>BC066643-1|AAH66643.1| 1202|Homo sapiens CASK interacting protein 2
protein.
Length = 1202
Score = 93.9 bits (223), Expect = 6e-18
Identities = 75/229 (32%), Positives = 109/229 (47%), Gaps = 12/229 (5%)
Query: 950 TNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAH 1009
T V+ D +G SALH AA G L++ LL +A ++ K NG LH AA G
Sbjct: 37 TKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLE 96
Query: 1010 LVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA 1069
V+ L+R +A ++ +L Q PLHLAA G EV ++LL+ +N ++ + P+ A
Sbjct: 97 PVRLLLR-ASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLA 155
Query: 1070 AQNNYSEVVQLFLQQH--PNLVMATTKDG-----NTCAHIAAIQGSVKVIEELMKFDRTG 1122
+ +V QL L H L+ KD T H+AA G +VI +L+ R G
Sbjct: 156 CEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLL---RAG 212
Query: 1123 VISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHL 1171
I + T L AA G +VVR+L+ G N TA+ +
Sbjct: 213 -IEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 260
Score = 90.2 bits (214), Expect = 7e-17
Identities = 70/221 (31%), Positives = 113/221 (51%), Gaps = 15/221 (6%)
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
+N Q++ G++ L A G ++L+ LL A VD+ D G LH AA G L+ L
Sbjct: 42 VNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLL 101
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
L A +N+ + +G+ LHLAA G+ + + L++ H + ++ K+TPL LA G+
Sbjct: 102 LRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQ-HQSNPCLVNKAKKTPLDLACEFGR 160
Query: 1042 IEVCKLLLEL--------GANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT 1093
++V +LLL G D D P+H AA+N + EV++ L+ + T
Sbjct: 161 LKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIE-INRQT 219
Query: 1094 KDGNTCAHIAAIQGSVKVIEELMKFDRTGV-ISARNKLNDS 1133
K G T H AA+ G +V+ L++ GV ++ RN N +
Sbjct: 220 KTG-TALHEAALYGKTEVVRLLLE---GGVDVNIRNTYNQT 256
Score = 82.2 bits (194), Expect = 2e-14
Identities = 72/222 (32%), Positives = 95/222 (42%), Gaps = 23/222 (10%)
Query: 1165 GLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGT 1224
G +A+H AA G ++ ++ G+ PLH AA+ G+ E VR LL
Sbjct: 49 GFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLR----- 103
Query: 1225 VKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLH 1284
S A SL G PLHLAA G+ V +LL N+ PL
Sbjct: 104 -ASAAVNAASL-------DGQIPLHLAAQYGHYEVSEMLLQHQS--NPCLVNKAKKTPLD 153
Query: 1285 LACFGGHMSIVGLLLSR-------SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGA 1337
LAC G + + LLL+ E D + T LH+A+ +GH +++ LL G
Sbjct: 154 LACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGI 213
Query: 1338 EINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLN 1379
EIN K G T LH AA G VV+LL E G N
Sbjct: 214 EINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYN 254
Score = 81.8 bits (193), Expect = 2e-14
Identities = 69/229 (30%), Positives = 112/229 (48%), Gaps = 16/229 (6%)
Query: 1095 DGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRA 1154
DG + H AA+ GS+++I L++ T I N + PL AA G + VR+L+RA
Sbjct: 48 DGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMR---PLHYAAWQGRLEPVRLLLRA 104
Query: 1155 GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETV 1214
A+ + G +HLAA++GH V +++ + K TPL +A +G+ +
Sbjct: 105 SAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVA 164
Query: 1215 RELL-SHV-PGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
+ LL SH+ ++ EA + TPLHLAA NG+ V+R LL AG++ +
Sbjct: 165 QLLLNSHLCVALLEGEAKDPCD-------PNYTTPLHLAAKNGHREVIRQLLR-AGIEIN 216
Query: 1273 AASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIAS 1321
+ LH A G +V LLL + ++ + + +T L I +
Sbjct: 217 RQTKTG--TALHEAALYGKTEVVRLLLEGGVD-VNIRNTYNQTALDIVN 262
Score = 77.8 bits (183), Expect = 4e-13
Identities = 74/265 (27%), Positives = 122/265 (46%), Gaps = 31/265 (11%)
Query: 1102 IAAIQGSVKVIEELM---KFDRTGVISARNKLNDS-------TPLQLAAEGGHADVVRVL 1151
+A G V +++L+ K +T ++ + +LN + + L AA GG +++ +L
Sbjct: 9 LAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALL 68
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQA 1211
+ A A+ ++ G+ +H AA G + ++ + ++ G PLH+AA YG
Sbjct: 69 LEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHY 128
Query: 1212 ETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS----A 1267
E LL H P L ++ TPL LA G V +LLLNS A
Sbjct: 129 EVSEMLLQHQSN-------------PCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVA 175
Query: 1268 GVQADAAS--NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGH 1325
++ +A + N PLHLA GH ++ LL E+ T + G T LH A+ +G
Sbjct: 176 LLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQT-KTG-TALHEAALYGK 233
Query: 1326 YQMVEVLLGQGAEINATDKNGWTPL 1350
++V +LL G ++N + T L
Sbjct: 234 TEVVRLLLEGGVDVNIRNTYNQTAL 258
Score = 74.5 bits (175), Expect = 4e-12
Identities = 63/206 (30%), Positives = 94/206 (45%), Gaps = 11/206 (5%)
Query: 1202 LHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVR 1261
L +A G V++L++ V T + L G + LH AA G+ ++
Sbjct: 7 LILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIA 66
Query: 1262 LLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIAS 1321
LLL A D + NG PLH A + G + V LLL SA + ++ G+ LH+A+
Sbjct: 67 LLLE-AQATVDI-KDSNGMRPLHYAAWQGRLEPVRLLLRASAAV-NAASLDGQIPLHLAA 123
Query: 1322 THGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESG---ASPKSETNL 1378
+GHY++ E+LL + +K TPL A + G L V +LL S A + E
Sbjct: 124 QYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKD 183
Query: 1379 NC-----APIWFAASENHNDVLEYLL 1399
C P+ AA H +V+ LL
Sbjct: 184 PCDPNYTTPLHLAAKNGHREVIRQLL 209
Score = 71.3 bits (167), Expect = 3e-11
Identities = 70/226 (30%), Positives = 102/226 (45%), Gaps = 26/226 (11%)
Query: 1183 VMRSTNTLRISSKKL-GLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGA 1241
++ ST L ++ + G + LH AA G E + LL EA V +
Sbjct: 33 LLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLL---------EAQATVDIKD---- 79
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+G+ PLH AA+ G VRLLL A +AAS + G PLHLA GH + +LL
Sbjct: 80 SNGMRPLHYAAWQGRLEPVRLLLR-ASAAVNAASLD-GQIPLHLAAQYGHYEVSEMLLQH 137
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG--------QGAEINATDKNGWTPLHCA 1353
+ ++ KT L +A G ++ ++LL +G + D N TPLH A
Sbjct: 138 QSNPC-LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLA 196
Query: 1354 AKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
AK GH V++ L +G +T A + AA +V+ LL
Sbjct: 197 AKNGHREVIRQLLRAGIEINRQTKTGTA-LHEAALYGKTEVVRLLL 241
Score = 70.9 bits (166), Expect = 4e-11
Identities = 75/265 (28%), Positives = 119/265 (44%), Gaps = 32/265 (12%)
Query: 844 DEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN 903
D DG SALH+A +++ L+E A V ++ N HY A G
Sbjct: 46 DADGFSALHHAAL---------GGSLELIALLLEAQATVDIKDS-NGMRPLHYAAWQGRL 95
Query: 904 DVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGR 963
+ + ++ S A+N + G PL +A GH ++ LL + + + + +
Sbjct: 96 EPVRLLLR------ASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKK 149
Query: 964 SALHLAAEHGYLQVCDALLTNK---AFINSKAR-----NGRTALHLAAMNGYAHLVKFLI 1015
+ L LA E G L+V LL + A + +A+ N T LHLAA NG+ +++ L+
Sbjct: 150 TPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLL 209
Query: 1016 RDHNAMIDV-LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNY 1074
R A I++ K T LH AA G+ EV +LLLE G +++ + Q + Q
Sbjct: 210 R---AGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTT 266
Query: 1075 S----EVVQLFLQQHPNLVMATTKD 1095
S E+ QL + L + KD
Sbjct: 267 SQASREIKQLLREASGILKVRALKD 291
Score = 66.1 bits (154), Expect = 1e-09
Identities = 38/123 (30%), Positives = 60/123 (48%), Gaps = 1/123 (0%)
Query: 1278 NGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGA 1337
+G++ LH A GG + ++ LLL A + D +G LH A+ G + V +LL A
Sbjct: 48 DGFSALHHAALGGSLELIALLLEAQATV-DIKDSNGMRPLHYAAWQGRLEPVRLLLRASA 106
Query: 1338 EINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEY 1397
+NA +G PLH AA+ GH V ++L + ++P P+ A V +
Sbjct: 107 AVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQL 166
Query: 1398 LLH 1400
LL+
Sbjct: 167 LLN 169
Score = 65.7 bits (153), Expect = 2e-09
Identities = 46/167 (27%), Positives = 80/167 (47%), Gaps = 9/167 (5%)
Query: 70 AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNG 129
A G+ ++ LL AQ +K + G LH AA + ++ R+L+ A V+A +
Sbjct: 56 AALGGSLELIALLLEAQATVDIKDSN--GMRPLHYAAWQGRLEPVRLLLRASAAVNAASL 113
Query: 130 AGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKF-- 187
GQ PLH+AA G + + ++N + + +TP+ LA E G + +LL +
Sbjct: 114 DGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLC 173
Query: 188 KASIFERTKDG-----STLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
A + KD +T +H+A+ NGH + L + G+ ++ K
Sbjct: 174 VALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTK 220
Score = 56.8 bits (131), Expect = 8e-07
Identities = 60/222 (27%), Positives = 101/222 (45%), Gaps = 28/222 (12%)
Query: 688 SVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCA 747
+V+ D ++ALH A ++ LL A V I+ PLH AA +
Sbjct: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMR-PLHYAAWQGRLEPVR 99
Query: 748 LMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETP 807
L LL++ A N A+ DG P+H+AA++G+ +LL+ +P C+ + +TP
Sbjct: 100 L-LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNP------CLVNKAK-KTP 151
Query: 808 LQMACRSCMPDIVRHLIE---FVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKI 864
L +AC + + L+ V +GE+ D D + + LH A K
Sbjct: 152 LDLACEFGRLKVAQLLLNSHLCVALLEGEAK-----DPCDPNYTTPLHLAAK-------- 198
Query: 865 PTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVM 906
R+V++ L+ G +++ QT+ TA H A+ G +V+
Sbjct: 199 -NGHREVIRQLLRAGIEINRQTKTG--TALHEAALYGKTEVV 237
Score = 56.8 bits (131), Expect = 8e-07
Identities = 44/136 (32%), Positives = 68/136 (50%), Gaps = 11/136 (8%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DG +H AA+YGH + LLQ + + T L +A E + V + LL
Sbjct: 114 DGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLC 173
Query: 722 VHIRGGKQRE-------TPLHIAARIPDGDKCAL-MLLKSGAGPNKATEDGMTPVHVAAK 773
V + G+ ++ TPLH+AA+ +G + + LL++G N+ T+ G T +H AA
Sbjct: 174 VALLEGEAKDPCDPNYTTPLHLAAK--NGHREVIRQLLRAGIEINRQTKTG-TALHEAAL 230
Query: 774 FGNLATLVLLLEDGGD 789
+G + LLLE G D
Sbjct: 231 YGKTEVVRLLLEGGVD 246
Score = 54.8 bits (126), Expect = 3e-06
Identities = 31/93 (33%), Positives = 47/93 (50%)
Query: 1310 DRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESG 1369
D G + LH A+ G +++ +LL A ++ D NG PLH AA G L V+LL +
Sbjct: 46 DADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRAS 105
Query: 1370 ASPKSETNLNCAPIWFAASENHNDVLEYLLHKE 1402
A+ + + P+ AA H +V E LL +
Sbjct: 106 AAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQ 138
Score = 52.4 bits (120), Expect = 2e-05
Identities = 61/233 (26%), Positives = 103/233 (44%), Gaps = 23/233 (9%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y+ DG ++H AA G + +I LL+ +VD+ ++ LH A + V LL
Sbjct: 44 YQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLR 103
Query: 718 YGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
A V+ + PLH+AA+ + + MLL+ + P + TP+ +A +FG L
Sbjct: 104 ASAAVN-AASLDGQIPLHLAAQYGHYE-VSEMLLQHQSNPCLVNKAKKTPLDLACEFGRL 161
Query: 778 ATLVLLLEDG-GDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVS 836
LLL L + + TPL +A ++ +++R L+ +
Sbjct: 162 KVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLR----------A 211
Query: 837 TAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHN 889
I+ + G +ALH A K E VV+ L+E G DV+++ +N
Sbjct: 212 GIEINRQTKTG-TALHEAALYGKTE---------VVRLLLEGGVDVNIRNTYN 254
Score = 52.4 bits (120), Expect = 2e-05
Identities = 32/88 (36%), Positives = 51/88 (57%), Gaps = 4/88 (4%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G +ALH AA +++ +L++ A VD + G PLH AA +G V+ +RA+A
Sbjct: 49 GFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLL--LRASA 106
Query: 158 AI--ADNEDRTPMHLAAENGHAAIIELL 183
A+ A + + P+HLAA+ GH + E+L
Sbjct: 107 AVNAASLDGQIPLHLAAQYGHYEVSEML 134
Score = 43.6 bits (98), Expect = 0.008
Identities = 27/96 (28%), Positives = 45/96 (46%), Gaps = 1/96 (1%)
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
V+ + G + LH AA G L+ +A I D+ P+H AA G + LL
Sbjct: 42 VNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLL 101
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
+ A++ + DG +H+A+ GH + + ML +
Sbjct: 102 L-RASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQ 136
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/72 (36%), Positives = 40/72 (55%), Gaps = 3/72 (4%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA + G++ ++R+LL A ++ T G TALH AA ++ R+L++ G V+
Sbjct: 192 PLHLAAKNGHREVIRQLLRAGI--EINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVN 248
Query: 126 ATNGAGQTPLHI 137
N QT L I
Sbjct: 249 IRNTYNQTALDI 260
>AK098479-1|BAC05314.1| 353|Homo sapiens protein ( Homo sapiens cDNA
FLJ25613 fis, clone STM01546. ).
Length = 353
Score = 93.9 bits (223), Expect = 6e-18
Identities = 73/210 (34%), Positives = 104/210 (49%), Gaps = 17/210 (8%)
Query: 1200 TPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSL---VPVLGAESG------LTPLHL 1250
TPLH AAY G ++ LL + G + + +P + + +P GA L PLH
Sbjct: 42 TPLHAAAYVGDVPILQLLL--ITGFLHTSSPPSIKIGNYIPT-GANVNAKDTLWLAPLHR 98
Query: 1251 AAYNGNENVVRLLL-NSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHST 1309
AA + NE V+ LLL +SA V A ++ PLH+A + L+ L+
Sbjct: 99 AAASRNEKVLGLLLAHSADVNA---RDKLWQTPLHVAA-ANRATKCAEALAPLLSSLNVA 154
Query: 1310 DRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESG 1369
DR G++ LH A GH + V +LL +GA +N DK PLH AA GHL V+KLL G
Sbjct: 155 DRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARG 214
Query: 1370 ASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
A + + AA+ +V++YLL
Sbjct: 215 ADLGCKDRKGYGLLHTAAASGQIEVVKYLL 244
Score = 91.9 bits (218), Expect = 2e-17
Identities = 74/238 (31%), Positives = 119/238 (50%), Gaps = 10/238 (4%)
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
+N ++++ PL A + +++ LL + A V+ D ++ LH+AA + + +AL
Sbjct: 85 VNAKDTLWLAPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL 144
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
+ +N R+GR+ALH A +G+ V L+ + A ++V K++ PLH AA G
Sbjct: 145 APLLSSLNVADRSGRSALHHAVHSGHLETVNLLL-NKGASLNVCDKKERQPLHWAAFLGH 203
Query: 1042 IEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAH 1101
+EV KLL+ GA++ D G +H AA + EVV+ L+ + GNT H
Sbjct: 204 LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAE-IDEPNAFGNTALH 262
Query: 1102 IAAIQGSVKVIEELMKFDRTGVISARNKLNDS--TPLQLAAEGGH-ADVVRVLVRAGA 1156
IA G V EL+ + N+ ND TPL +AA + A + +LV GA
Sbjct: 263 IACYLGQDAVAIELVNAG-----ANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGA 315
Score = 90.6 bits (215), Expect = 5e-17
Identities = 67/203 (33%), Positives = 102/203 (50%), Gaps = 8/203 (3%)
Query: 868 DRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNS 927
+ +V+ L+ + ADV+ + + +T H A A E +A + ++ LN +
Sbjct: 104 NEKVLGLLLAHSADVNARDKL-WQTPLHVAA-ANRATKCAEALAPLLSS-----LNVADR 156
Query: 928 IGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAF 987
G + L A H GH++ VN LL A ++V D + R LH AA G+L+V L+ A
Sbjct: 157 SGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGAD 216
Query: 988 INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKL 1047
+ K R G LH AA +G +VK+L+R A ID T LH+A GQ V
Sbjct: 217 LGCKDRKGYGLLHTAAASGQIEVVKYLLR-MGAEIDEPNAFGNTALHIACYLGQDAVAIE 275
Query: 1048 LLELGANIDATDELGQKPIHAAA 1070
L+ GAN++ ++ G P+H AA
Sbjct: 276 LVNAGANVNQPNDKGFTPLHVAA 298
Score = 85.8 bits (203), Expect = 1e-15
Identities = 71/236 (30%), Positives = 110/236 (46%), Gaps = 18/236 (7%)
Query: 1032 PLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMA 1091
PLH AAAS +V LLL A+++A D+L Q P+H AA N ++ + +L +A
Sbjct: 95 PLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVA 154
Query: 1092 TTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL 1151
+ G + H A G ++ + L+ ++ ++ +K + PL AA GH +V+++L
Sbjct: 155 D-RSGRSALHHAVHSGHLETVNLLL--NKGASLNVCDK-KERQPLHWAAFLGHLEVLKLL 210
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQA 1211
V GA ++R G +H AA G V+ + G T LHIA Y GQ
Sbjct: 211 VARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQD 270
Query: 1212 ETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENV-VRLLLNS 1266
EL V P + G TPLH+AA + N + + LL+N+
Sbjct: 271 AVAIEL---VNAGANVNQPN----------DKGFTPLHVAAVSTNGALCLELLVNN 313
Score = 85.4 bits (202), Expect = 2e-15
Identities = 79/250 (31%), Positives = 117/250 (46%), Gaps = 17/250 (6%)
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQA 1211
+ GA+ ++ L +H AA + VL ++ + + + KL TPLH+AA +A
Sbjct: 79 IPTGANVNAKDTLWLAPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAA-NRA 137
Query: 1212 ETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQA 1271
E L AP SL + SG + LH A ++G+ V LLLN G
Sbjct: 138 TKCAEAL----------APLLSSLN--VADRSGRSALHHAVHSGHLETVNLLLNK-GASL 184
Query: 1272 DAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEV 1331
+ + PLH A F GH+ ++ LL++R A+L DR G LH A+ G ++V+
Sbjct: 185 NVCDKKER-QPLHWAAFLGHLEVLKLLVARGADL-GCKDRKGYGLLHTAAASGQIEVVKY 242
Query: 1332 LLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAA-SEN 1390
LL GAEI+ + G T LH A G V L +GA+ + P+ AA S N
Sbjct: 243 LLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTN 302
Query: 1391 HNDVLEYLLH 1400
LE L++
Sbjct: 303 GALCLELLVN 312
Score = 84.6 bits (200), Expect = 3e-15
Identities = 66/229 (28%), Positives = 108/229 (47%), Gaps = 5/229 (2%)
Query: 945 VNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAM 1004
+ + A V+ D + LH AA +V LL + A +N++ + +T LH+AA
Sbjct: 75 IGNYIPTGANVNAKDTLWLAPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAA 134
Query: 1005 NGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQK 1064
N + L + ++V ++ LH A SG +E LLL GA+++ D+ ++
Sbjct: 135 NRATKCAEAL-APLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQ 193
Query: 1065 PIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVI 1124
P+H AA + EV++L + + +L K G H AA G ++V++ L+ R G
Sbjct: 194 PLHWAAFLGHLEVLKLLVARGADLGCKDRK-GYGLLHTAAASGQIEVVKYLL---RMGAE 249
Query: 1125 SARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAA 1173
+T L +A G V LV AGA+ N G T +H+AA
Sbjct: 250 IDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAA 298
Score = 79.0 bits (186), Expect = 2e-13
Identities = 67/238 (28%), Positives = 113/238 (47%), Gaps = 14/238 (5%)
Query: 1143 GHADVVRVLVRAGASCT---DENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSK---K 1196
G ++ L RA C+ +++ T +H AA G +L ++ T L SS K
Sbjct: 15 GLGSLIAPLPRAHTPCSFLPSQDQERRTPLHAAAYVGDVPILQLLLITGFLHTSSPPSIK 74
Query: 1197 LGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPV--LGAESGL--TPLHLAA 1252
+G + A +T+ H ++E G+ L + A L TPLH+AA
Sbjct: 75 IG-NYIPTGANVNAKDTLWLAPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAA 133
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
N L + + + ++ +G + LH A GH+ V LLL++ A L + D+
Sbjct: 134 ANRATKCAEAL--APLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASL-NVCDKK 190
Query: 1313 GKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
+ LH A+ GH +++++L+ +GA++ D+ G+ LH AA +G + VVK L GA
Sbjct: 191 ERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGA 248
Score = 64.1 bits (149), Expect = 5e-09
Identities = 44/165 (26%), Positives = 78/165 (47%), Gaps = 3/165 (1%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL A + N+ ++ LL A +A+ + A T LH+AA R A L + ++
Sbjct: 95 PLHRAAASRNEKVLG-LLLAHSAD-VNARDKLWQTPLHVAAANRATKCAEALAPLLSSLN 152
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
+ +G++ LH A G V A+ + D ++R P+H AA GH +++LL
Sbjct: 153 VADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVA 212
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKY 230
+ A + + + G L+H A+ +G + L + G + PN +
Sbjct: 213 R-GADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAF 256
Score = 63.3 bits (147), Expect = 9e-09
Identities = 41/122 (33%), Positives = 61/122 (50%), Gaps = 2/122 (1%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA GH+ ++ L+ +G + Y LH A S + VV+ LL GA++
Sbjct: 195 LHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEID-EP 253
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
T LHIA + D A+ L+ +GA N+ + G TP+HVAA N A + LL +
Sbjct: 254 NAFGNTALHIACYLGQ-DAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVN 312
Query: 787 GG 788
G
Sbjct: 313 NG 314
Score = 56.8 bits (131), Expect = 8e-07
Identities = 42/160 (26%), Positives = 70/160 (43%), Gaps = 1/160 (0%)
Query: 69 LAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATN 128
L V A N++ A L +G +ALH A ++ +L++ GA ++ +
Sbjct: 129 LHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCD 188
Query: 129 GAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKFK 188
+ PLH AA G ++K A+ D + +H AA +G +++ L +
Sbjct: 189 KKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLL-RMG 247
Query: 189 ASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPN 228
A I E G+T +HIA G A+ L G ++ PN
Sbjct: 248 AEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPN 287
Score = 54.4 bits (125), Expect = 4e-06
Identities = 32/89 (35%), Positives = 49/89 (55%), Gaps = 1/89 (1%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+HTAA G + ++ LL+ G +D TALHIA + AV L+ GA+V+ +
Sbjct: 228 LHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVN-QP 286
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGA 755
+ TPLH+AA +G C +L+ +GA
Sbjct: 287 NDKGFTPLHVAAVSTNGALCLELLVNNGA 315
Score = 53.2 bits (122), Expect = 1e-05
Identities = 66/270 (24%), Positives = 112/270 (41%), Gaps = 33/270 (12%)
Query: 751 LKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQM 810
+ +GA N + P+H AA N L LLL D + K+ +TPL +
Sbjct: 79 IPTGANVNAKDTLWLAPLHRAAASRNEKVLGLLLAHSADVNARDKL-------WQTPLHV 131
Query: 811 ACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQ 870
A + L + ++ D G SALH+A + + +
Sbjct: 132 AAANRATKCAEALAPLLSS----------LNVADRSGRSALHHA---------VHSGHLE 172
Query: 871 VVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGW 930
V L+ GA +++ + + H+ A G+ +V+ ++A AD L ++ G+
Sbjct: 173 TVNLLLNKGASLNVCDKKERQ-PLHWAAFLGHLEVLKLLVAR--GAD----LGCKDRKGY 225
Query: 931 TPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINS 990
L A G +++V LL A +D + G +ALH+A G V L+ A +N
Sbjct: 226 GLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQ 285
Query: 991 KARNGRTALHLAAMNGYAHLVKFLIRDHNA 1020
G T LH+AA++ L L+ ++ A
Sbjct: 286 PNDKGFTPLHVAAVSTNGALCLELLVNNGA 315
Score = 52.8 bits (121), Expect = 1e-05
Identities = 74/274 (27%), Positives = 111/274 (40%), Gaps = 35/274 (12%)
Query: 679 INTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAA 738
I + G +V+ LH A S V+ LL + ADV+ R K +TPLH+AA
Sbjct: 75 IGNYIPTGANVNAKDTLWLAPLHRAAASRNEKVLGLLLAHSADVNAR-DKLWQTPLHVAA 133
Query: 739 RIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCI 798
KCA L + N A G + +H A G+L T+ LLL G VC
Sbjct: 134 -ANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGA----SLNVC- 187
Query: 799 YDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVT 858
D + PL A ++++ L+ +G A + D G LH A
Sbjct: 188 -DKKERQ-PLHWAAFLGHLEVLKLLVA-----RG-----ADLGCKDRKGYGLLHTAA--- 232
Query: 859 KEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADV 918
+ +VVK L+ GA++ + TA H G + V E++ +
Sbjct: 233 ------ASGQIEVVKYLLRMGAEIDEPNAFGN-TALHIACYLGQDAVAIELV------NA 279
Query: 919 SRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNH 952
+N+ N G+TPL +A + L LL N+
Sbjct: 280 GANVNQPNDKGFTPLHVAAVSTNGALCLELLVNN 313
Score = 51.2 bits (117), Expect = 4e-05
Identities = 37/126 (29%), Positives = 64/126 (50%), Gaps = 3/126 (2%)
Query: 61 QRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDY 120
++ + PL A G+ +++ LL A+ A+ L G LH AA +++ + L+
Sbjct: 189 KKERQPLHWAAFLGHLEVLK-LLVARGAD-LGCKDRKGYGLLHTAAASGQIEVVKYLLRM 246
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAI- 179
GA +D N G T LHIA G + + AN +++ TP+H+AA + + A+
Sbjct: 247 GAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALC 306
Query: 180 IELLAD 185
+ELL +
Sbjct: 307 LELLVN 312
Score = 49.2 bits (112), Expect = 2e-04
Identities = 33/109 (30%), Positives = 53/109 (48%), Gaps = 1/109 (0%)
Query: 121 GAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAII 180
GA V+A + PLH AAA +E ++ A+ D +TP+H+AA N
Sbjct: 82 GANVNAKDTLWLAPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCA 141
Query: 181 ELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
E LA +S+ + G + +H A +GH + +L KG L++ +K
Sbjct: 142 EALA-PLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDK 189
Score = 48.0 bits (109), Expect = 4e-04
Identities = 37/127 (29%), Positives = 57/127 (44%), Gaps = 2/127 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++H A GH+ +N LL KG S++V LH A V++ L+ GAD+
Sbjct: 158 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADL 217
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVL 782
+ K LH AA + LL+ GA ++ G T +H+A G A +
Sbjct: 218 GCKDRKGYGL-LHTAA-ASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIE 275
Query: 783 LLEDGGD 789
L+ G +
Sbjct: 276 LVNAGAN 282
Score = 41.1 bits (92), Expect = 0.041
Identities = 35/123 (28%), Positives = 53/123 (43%), Gaps = 2/123 (1%)
Query: 667 IHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRG 726
+H AA L S++V +ALH AV S V LL GA +++
Sbjct: 129 LHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCD 188
Query: 727 GKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLED 786
K+R+ PLH AA + + L++ + GA G +H AA G + + LL
Sbjct: 189 KKERQ-PLHWAAFLGHLEVLKLLVAR-GADLGCKDRKGYGLLHTAAASGQIEVVKYLLRM 246
Query: 787 GGD 789
G +
Sbjct: 247 GAE 249
>AK091120-1|BAC03587.1| 1001|Homo sapiens protein ( Homo sapiens cDNA
FLJ33801 fis, clone CTONG2000411. ).
Length = 1001
Score = 93.9 bits (223), Expect = 6e-18
Identities = 65/185 (35%), Positives = 93/185 (50%), Gaps = 3/185 (1%)
Query: 933 LLIACHRGHMQLVNTLLTNH-ARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSK 991
LL A HRG + V L + AR D G+S HLAA G + LL N A INSK
Sbjct: 24 LLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSK 83
Query: 992 ARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLEL 1051
+G TALHLA ++ VK L++ H A D + + ++PLH AA+SG LL +
Sbjct: 84 NEDGSTALHLATISCQPQCVKVLLQ-HGANEDAVDAENRSPLHWAASSGCASSVLLLCDH 142
Query: 1052 GANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKV 1111
A +D D G+ P+ A+ ++ + LQ+ V T K+ +A +GS +V
Sbjct: 143 EAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGAR-VNVTDKNDKAALILACEKGSAEV 201
Query: 1112 IEELM 1116
E L+
Sbjct: 202 AELLL 206
Score = 83.8 bits (198), Expect = 6e-15
Identities = 56/178 (31%), Positives = 88/178 (49%), Gaps = 2/178 (1%)
Query: 926 NSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNK 985
+S G +P +A +G + + LL N A ++ + +G +ALHLA Q LL +
Sbjct: 51 DSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHG 110
Query: 986 AFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVC 1045
A ++ R+ LH AA +G A V L+ DH A +DVL +TPL +A+ G +C
Sbjct: 111 ANEDAVDAENRSPLHWAASSGCASSV-LLLCDHEAFLDVLDNDGRTPLMIASLGGHAAIC 169
Query: 1046 KLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIA 1103
LL+ GA ++ TD+ + + A + +EV +L L H A G+ H A
Sbjct: 170 SQLLQRGARVNVTDKNDKAALILACEKGSAEVAELLL-SHGADAGAVDSTGHDALHYA 226
Score = 83.4 bits (197), Expect = 8e-15
Identities = 59/181 (32%), Positives = 88/181 (48%), Gaps = 7/181 (3%)
Query: 889 NHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTL 948
N ++ FH A G + +T ++A+ AD+ N +N G T L +A Q V L
Sbjct: 53 NGQSPFHLAASKGLTECLTILLAN--GADI----NSKNEDGSTALHLATISCQPQCVKVL 106
Query: 949 LTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYA 1008
L + A D D E RS LH AA G L ++AF++ +GRT L +A++ G+A
Sbjct: 107 LQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHA 166
Query: 1009 HLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHA 1068
+ L++ A ++V + L LA G EV +LLL GA+ A D G +H
Sbjct: 167 AICSQLLQ-RGARVNVTDKNDKAALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHY 225
Query: 1069 A 1069
A
Sbjct: 226 A 226
Score = 81.0 bits (191), Expect = 4e-14
Identities = 72/242 (29%), Positives = 106/242 (43%), Gaps = 16/242 (6%)
Query: 1112 IEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHL 1171
++ + T V R +D L+ G V + R A T + G + HL
Sbjct: 1 MKRIFSCSSTQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHL 60
Query: 1172 AAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT 1231
AA G T L ++ + S + G T LH+A Q + V+ LL H
Sbjct: 61 AASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQH----------- 109
Query: 1232 GVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGH 1291
G + + AE+ +PLH AA +G + V LL + D N+ G PL +A GGH
Sbjct: 110 GAN-EDAVDAENR-SPLHWAASSGCASSVLLLCDHEAF-LDVLDND-GRTPLMIASLGGH 165
Query: 1292 MSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLH 1351
+I LL R A + + TD++ K L +A G ++ E+LL GA+ A D G LH
Sbjct: 166 AAICSQLLQRGARV-NVTDKNDKAALILACEKGSAEVAELLLSHGADAGAVDSTGHDALH 224
Query: 1352 CA 1353
A
Sbjct: 225 YA 226
Score = 81.0 bits (191), Expect = 4e-14
Identities = 55/163 (33%), Positives = 82/163 (50%), Gaps = 2/163 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
LL AV G+ V L S ++A K + G + HLAA + + IL+ GA +++
Sbjct: 24 LLEAVHRGDVGRVAALASRKSARPTKLDSN-GQSPFHLAASKGLTECLTILLANGADINS 82
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADK 186
N G T LH+A VK AN D E+R+P+H AA +G A+ + LL D
Sbjct: 83 KNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDH 142
Query: 187 FKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
+A + DG T + IASL GHA L ++G +++ +K
Sbjct: 143 -EAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDK 184
Score = 77.4 bits (182), Expect = 5e-13
Identities = 70/205 (34%), Positives = 91/205 (44%), Gaps = 19/205 (9%)
Query: 1166 LTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTV 1225
L AVH + G L +S ++ S G +P H+AA G E + LL++ +
Sbjct: 25 LEAVH-RGDVGRVAALASRKSARPTKLDSN--GQSPFHLAASKGLTECLTILLAN-GADI 80
Query: 1226 KSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHL 1285
S+ E G T LHLA + V++LL G DA EN +PLH
Sbjct: 81 NSKN------------EDGSTALHLATISCQPQCVKVLLQH-GANEDAVDAENR-SPLHW 126
Query: 1286 ACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKN 1345
A G S V LL A L D G+T L IAS GH + LL +GA +N TDKN
Sbjct: 127 AASSGCASSVLLLCDHEA-FLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKN 185
Query: 1346 GWTPLHCAAKAGHLNVVKLLCESGA 1370
L A + G V +LL GA
Sbjct: 186 DKAALILACEKGSAEVAELLLSHGA 210
Score = 68.5 bits (160), Expect = 2e-10
Identities = 42/126 (33%), Positives = 63/126 (50%), Gaps = 1/126 (0%)
Query: 1276 NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQ 1335
+ NG +P HLA G + +LL+ A++ +S + G T LH+A+ Q V+VLL
Sbjct: 51 DSNGQSPFHLAASKGLTECLTILLANGADI-NSKNEDGSTALHLATISCQPQCVKVLLQH 109
Query: 1336 GAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVL 1395
GA +A D +PLH AA +G + V LLC+ A N P+ A+ H +
Sbjct: 110 GANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAIC 169
Query: 1396 EYLLHK 1401
LL +
Sbjct: 170 SQLLQR 175
Score = 67.3 bits (157), Expect = 6e-10
Identities = 47/159 (29%), Positives = 72/159 (45%), Gaps = 3/159 (1%)
Query: 63 GKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGA 122
G+ P LA G + LL+ + + G TALHLA ++L+ +GA
Sbjct: 54 GQSPFHLAASKGLTECLTILLA--NGADINSKNEDGSTALHLATISCQPQCVKVLLQHGA 111
Query: 123 VVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIEL 182
DA + ++PLH AA+ G V A + DN+ RTP+ +A+ GHAAI
Sbjct: 112 NEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQ 171
Query: 183 LADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG 221
L + A + K+ + +A G A+ A +L G
Sbjct: 172 LLQR-GARVNVTDKNDKAALILACEKGSAEVAELLLSHG 209
Score = 66.9 bits (156), Expect = 7e-10
Identities = 50/178 (28%), Positives = 82/178 (46%), Gaps = 4/178 (2%)
Query: 1030 QTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLV 1089
Q+P HLAA+ G E +LL GA+I++ +E G +H A + + V++ LQ N
Sbjct: 55 QSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGAN-E 113
Query: 1090 MATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVR 1149
A + + H AA G + L+ D + + + TPL +A+ GGHA +
Sbjct: 114 DAVDAENRSPLHWAASSGCASSV--LLLCDHEAFLDVLDN-DGRTPLMIASLGGHAAICS 170
Query: 1150 VLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAY 1207
L++ GA ++ A+ LA E G V +++ S + G LH A +
Sbjct: 171 QLLQRGARVNVTDKNDKAALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALH 228
Score = 62.9 bits (146), Expect = 1e-08
Identities = 57/193 (29%), Positives = 84/193 (43%), Gaps = 19/193 (9%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
+G H AA G + LL G ++ D TALH+A SC+P V+ LL +GA+
Sbjct: 53 NGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGAN 112
Query: 722 VHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLV 781
+ R +PLH AA L+L A + DG TP+ +A+ G+ A
Sbjct: 113 EDAVDAENR-SPLHWAASSGCASS-VLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICS 170
Query: 782 LLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFID 841
LL+ G +V + D + L +AC ++ E + H ++
Sbjct: 171 QLLQRG------ARVNVTD-KNDKAALILACEKGSAEVA----ELLLSHGADA------G 213
Query: 842 AVDEDGASALHYA 854
AVD G ALHYA
Sbjct: 214 AVDSTGHDALHYA 226
Score = 62.5 bits (145), Expect = 2e-08
Identities = 48/158 (30%), Positives = 71/158 (44%), Gaps = 5/158 (3%)
Query: 1243 SGLTPLHLAAYNG-NENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+G +P HLAA G E + LL N A + + NE+G LHLA V +LL
Sbjct: 53 NGQSPFHLAASKGLTECLTILLANGADINS---KNEDGSTALHLATISCQPQCVKVLLQH 109
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNV 1361
A + D ++ LH A++ G V +L A ++ D +G TPL A+ GH +
Sbjct: 110 GANE-DAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAI 168
Query: 1362 VKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
L + GA + A + A + +V E LL
Sbjct: 169 CSQLLQRGARVNVTDKNDKAALILACEKGSAEVAELLL 206
Score = 56.0 bits (129), Expect = 1e-06
Identities = 53/228 (23%), Positives = 94/228 (41%), Gaps = 33/228 (14%)
Query: 742 DGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDV 801
D + A + + A P K +G +P H+AA G L +LL +G D K +
Sbjct: 32 DVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNE------ 85
Query: 802 VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEE 861
G T L +A SC P V+ L++ H DAVD + S LH+A
Sbjct: 86 -DGSTALHLATISCQPQCVKVLLQ----HGANE------DAVDAENRSPLHWAASSGCAS 134
Query: 862 VKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRA 921
+ D + +++N + T ++ G+ + ++++ + +V+
Sbjct: 135 SVLLLCDHEAFLDVLDN----------DGRTPLMIASLGGHAAICSQLLQRGARVNVTDK 184
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLA 969
++ L++AC +G ++ LL++ A D G ALH A
Sbjct: 185 NDK------AALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYA 226
Score = 55.6 bits (128), Expect = 2e-06
Identities = 31/99 (31%), Positives = 55/99 (55%)
Query: 1290 GHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP 1349
G + V L SR + D +G++ H+A++ G + + +LL GA+IN+ +++G T
Sbjct: 31 GDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTA 90
Query: 1350 LHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAAS 1388
LH A + VK+L + GA+ + N +P+ +AAS
Sbjct: 91 LHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAAS 129
Score = 43.2 bits (97), Expect = 0.010
Identities = 37/131 (28%), Positives = 58/131 (44%), Gaps = 2/131 (1%)
Query: 659 KHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGY 718
K+ DG+ ++H A + LLQ G + D +N + LH A S + V L +
Sbjct: 83 KNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDH 142
Query: 719 GADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
A + + R TPL IA+ C+ LL+ GA N ++ + +A + G+
Sbjct: 143 EAFLDVLDNDGR-TPLMIASLGGHAAICS-QLLQRGARVNVTDKNDKAALILACEKGSAE 200
Query: 779 TLVLLLEDGGD 789
LLL G D
Sbjct: 201 VAELLLSHGAD 211
Score = 42.7 bits (96), Expect = 0.014
Identities = 25/93 (26%), Positives = 46/93 (49%), Gaps = 2/93 (2%)
Query: 57 DLVFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI 116
D++ G+ PL++A G+ ++ +LL Q ++ T AL LA + ++A +
Sbjct: 147 DVLDNDGRTPLMIASLGGHAAICSQLL--QRGARVNVTDKNDKAALILACEKGSAEVAEL 204
Query: 117 LVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKY 149
L+ +GA A + G LH A D+ L ++
Sbjct: 205 LLSHGADAGAVDSTGHDALHYALHTQDKALWRH 237
>AF451976-1|AAL49757.1| 1202|Homo sapiens cask-interacting protein 2
protein.
Length = 1202
Score = 93.9 bits (223), Expect = 6e-18
Identities = 75/229 (32%), Positives = 109/229 (47%), Gaps = 12/229 (5%)
Query: 950 TNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAAMNGYAH 1009
T V+ D +G SALH AA G L++ LL +A ++ K NG LH AA G
Sbjct: 37 TKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLE 96
Query: 1010 LVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAA 1069
V+ L+R +A ++ +L Q PLHLAA G EV ++LL+ +N ++ + P+ A
Sbjct: 97 PVRLLLR-ASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLA 155
Query: 1070 AQNNYSEVVQLFLQQH--PNLVMATTKDG-----NTCAHIAAIQGSVKVIEELMKFDRTG 1122
+ +V QL L H L+ KD T H+AA G +VI +L+ R G
Sbjct: 156 CEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLL---RAG 212
Query: 1123 VISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHL 1171
I + T L AA G +VVR+L+ G N TA+ +
Sbjct: 213 -IEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDI 260
Score = 90.2 bits (214), Expect = 7e-17
Identities = 70/221 (31%), Positives = 113/221 (51%), Gaps = 15/221 (6%)
Query: 922 LNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDAL 981
+N Q++ G++ L A G ++L+ LL A VD+ D G LH AA G L+ L
Sbjct: 42 VNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLL 101
Query: 982 LTNKAFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQ 1041
L A +N+ + +G+ LHLAA G+ + + L++ H + ++ K+TPL LA G+
Sbjct: 102 LRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQ-HQSNPCLVNKAKKTPLDLACEFGR 160
Query: 1042 IEVCKLLLEL--------GANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATT 1093
++V +LLL G D D P+H AA+N + EV++ L+ + T
Sbjct: 161 LKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIE-INRQT 219
Query: 1094 KDGNTCAHIAAIQGSVKVIEELMKFDRTGV-ISARNKLNDS 1133
K G T H AA+ G +V+ L++ GV ++ RN N +
Sbjct: 220 KTG-TALHEAALYGKTEVVRLLLE---GGVDVNIRNTYNQT 256
Score = 82.2 bits (194), Expect = 2e-14
Identities = 72/222 (32%), Positives = 95/222 (42%), Gaps = 23/222 (10%)
Query: 1165 GLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGT 1224
G +A+H AA G ++ ++ G+ PLH AA+ G+ E VR LL
Sbjct: 49 GFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLR----- 103
Query: 1225 VKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLH 1284
S A SL G PLHLAA G+ V +LL N+ PL
Sbjct: 104 -ASAAVNAASL-------DGQIPLHLAAQYGHYEVSEMLLQHQS--NPCLVNKAKKTPLD 153
Query: 1285 LACFGGHMSIVGLLLSR-------SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGA 1337
LAC G + + LLL+ E D + T LH+A+ +GH +++ LL G
Sbjct: 154 LACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGI 213
Query: 1338 EINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLN 1379
EIN K G T LH AA G VV+LL E G N
Sbjct: 214 EINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYN 254
Score = 81.8 bits (193), Expect = 2e-14
Identities = 69/229 (30%), Positives = 112/229 (48%), Gaps = 16/229 (6%)
Query: 1095 DGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRA 1154
DG + H AA+ GS+++I L++ T I N + PL AA G + VR+L+RA
Sbjct: 48 DGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMR---PLHYAAWQGRLEPVRLLLRA 104
Query: 1155 GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQAETV 1214
A+ + G +HLAA++GH V +++ + K TPL +A +G+ +
Sbjct: 105 SAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVA 164
Query: 1215 RELL-SHV-PGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
+ LL SH+ ++ EA + TPLHLAA NG+ V+R LL AG++ +
Sbjct: 165 QLLLNSHLCVALLEGEAKDPCD-------PNYTTPLHLAAKNGHREVIRQLLR-AGIEIN 216
Query: 1273 AASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIAS 1321
+ LH A G +V LLL + ++ + + +T L I +
Sbjct: 217 RQTKTG--TALHEAALYGKTEVVRLLLEGGVD-VNIRNTYNQTALDIVN 262
Score = 77.8 bits (183), Expect = 4e-13
Identities = 74/265 (27%), Positives = 122/265 (46%), Gaps = 31/265 (11%)
Query: 1102 IAAIQGSVKVIEELM---KFDRTGVISARNKLNDS-------TPLQLAAEGGHADVVRVL 1151
+A G V +++L+ K +T ++ + +LN + + L AA GG +++ +L
Sbjct: 9 LAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALL 68
Query: 1152 VRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHIAAYYGQA 1211
+ A A+ ++ G+ +H AA G + ++ + ++ G PLH+AA YG
Sbjct: 69 LEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHY 128
Query: 1212 ETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNS----A 1267
E LL H P L ++ TPL LA G V +LLLNS A
Sbjct: 129 EVSEMLLQHQSN-------------PCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVA 175
Query: 1268 GVQADAAS--NENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGH 1325
++ +A + N PLHLA GH ++ LL E+ T + G T LH A+ +G
Sbjct: 176 LLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQT-KTG-TALHEAALYGK 233
Query: 1326 YQMVEVLLGQGAEINATDKNGWTPL 1350
++V +LL G ++N + T L
Sbjct: 234 TEVVRLLLEGGVDVNIRNTYNQTAL 258
Score = 74.5 bits (175), Expect = 4e-12
Identities = 63/206 (30%), Positives = 94/206 (45%), Gaps = 11/206 (5%)
Query: 1202 LHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVR 1261
L +A G V++L++ V T + L G + LH AA G+ ++
Sbjct: 7 LILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIA 66
Query: 1262 LLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIAS 1321
LLL A D + NG PLH A + G + V LLL SA + ++ G+ LH+A+
Sbjct: 67 LLLE-AQATVDI-KDSNGMRPLHYAAWQGRLEPVRLLLRASAAV-NAASLDGQIPLHLAA 123
Query: 1322 THGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESG---ASPKSETNL 1378
+GHY++ E+LL + +K TPL A + G L V +LL S A + E
Sbjct: 124 QYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKD 183
Query: 1379 NC-----APIWFAASENHNDVLEYLL 1399
C P+ AA H +V+ LL
Sbjct: 184 PCDPNYTTPLHLAAKNGHREVIRQLL 209
Score = 71.3 bits (167), Expect = 3e-11
Identities = 70/226 (30%), Positives = 102/226 (45%), Gaps = 26/226 (11%)
Query: 1183 VMRSTNTLRISSKKL-GLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGA 1241
++ ST L ++ + G + LH AA G E + LL EA V +
Sbjct: 33 LLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLL---------EAQATVDIKD---- 79
Query: 1242 ESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSR 1301
+G+ PLH AA+ G VRLLL A +AAS + G PLHLA GH + +LL
Sbjct: 80 SNGMRPLHYAAWQGRLEPVRLLLR-ASAAVNAASLD-GQIPLHLAAQYGHYEVSEMLLQH 137
Query: 1302 SAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG--------QGAEINATDKNGWTPLHCA 1353
+ ++ KT L +A G ++ ++LL +G + D N TPLH A
Sbjct: 138 QSNPC-LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLA 196
Query: 1354 AKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
AK GH V++ L +G +T A + AA +V+ LL
Sbjct: 197 AKNGHREVIRQLLRAGIEINRQTKTGTA-LHEAALYGKTEVVRLLL 241
Score = 70.9 bits (166), Expect = 4e-11
Identities = 75/265 (28%), Positives = 119/265 (44%), Gaps = 32/265 (12%)
Query: 844 DEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNN 903
D DG SALH+A +++ L+E A V ++ N HY A G
Sbjct: 46 DADGFSALHHAAL---------GGSLELIALLLEAQATVDIKDS-NGMRPLHYAAWQGRL 95
Query: 904 DVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGR 963
+ + ++ S A+N + G PL +A GH ++ LL + + + + +
Sbjct: 96 EPVRLLLR------ASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKK 149
Query: 964 SALHLAAEHGYLQVCDALLTNK---AFINSKAR-----NGRTALHLAAMNGYAHLVKFLI 1015
+ L LA E G L+V LL + A + +A+ N T LHLAA NG+ +++ L+
Sbjct: 150 TPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLL 209
Query: 1016 RDHNAMIDV-LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNY 1074
R A I++ K T LH AA G+ EV +LLLE G +++ + Q + Q
Sbjct: 210 R---AGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTT 266
Query: 1075 S----EVVQLFLQQHPNLVMATTKD 1095
S E+ QL + L + KD
Sbjct: 267 SQASREIKQLLREASGILKVRALKD 291
Score = 66.1 bits (154), Expect = 1e-09
Identities = 38/123 (30%), Positives = 60/123 (48%), Gaps = 1/123 (0%)
Query: 1278 NGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGA 1337
+G++ LH A GG + ++ LLL A + D +G LH A+ G + V +LL A
Sbjct: 48 DGFSALHHAALGGSLELIALLLEAQATV-DIKDSNGMRPLHYAAWQGRLEPVRLLLRASA 106
Query: 1338 EINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEY 1397
+NA +G PLH AA+ GH V ++L + ++P P+ A V +
Sbjct: 107 AVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQL 166
Query: 1398 LLH 1400
LL+
Sbjct: 167 LLN 169
Score = 65.7 bits (153), Expect = 2e-09
Identities = 46/167 (27%), Positives = 80/167 (47%), Gaps = 9/167 (5%)
Query: 70 AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDATNG 129
A G+ ++ LL AQ +K + G LH AA + ++ R+L+ A V+A +
Sbjct: 56 AALGGSLELIALLLEAQATVDIKDSN--GMRPLHYAAWQGRLEPVRLLLRASAAVNAASL 113
Query: 130 AGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLADKF-- 187
GQ PLH+AA G + + ++N + + +TP+ LA E G + +LL +
Sbjct: 114 DGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLC 173
Query: 188 KASIFERTKDG-----STLMHIASLNGHADCAMMLFKKGVYLHMPNK 229
A + KD +T +H+A+ NGH + L + G+ ++ K
Sbjct: 174 VALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTK 220
Score = 56.8 bits (131), Expect = 8e-07
Identities = 60/222 (27%), Positives = 101/222 (45%), Gaps = 28/222 (12%)
Query: 688 SVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAARIPDGDKCA 747
+V+ D ++ALH A ++ LL A V I+ PLH AA +
Sbjct: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMR-PLHYAAWQGRLEPVR 99
Query: 748 LMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETP 807
L LL++ A N A+ DG P+H+AA++G+ +LL+ +P C+ + +TP
Sbjct: 100 L-LLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNP------CLVNKAK-KTP 151
Query: 808 LQMACRSCMPDIVRHLIE---FVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKI 864
L +AC + + L+ V +GE+ D D + + LH A K
Sbjct: 152 LDLACEFGRLKVAQLLLNSHLCVALLEGEAK-----DPCDPNYTTPLHLAAK-------- 198
Query: 865 PTADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVM 906
R+V++ L+ G +++ QT+ TA H A+ G +V+
Sbjct: 199 -NGHREVIRQLLRAGIEINRQTKTG--TALHEAALYGKTEVV 237
Score = 56.8 bits (131), Expect = 8e-07
Identities = 44/136 (32%), Positives = 68/136 (50%), Gaps = 11/136 (8%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGAD 721
DG +H AA+YGH + LLQ + + T L +A E + V + LL
Sbjct: 114 DGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLC 173
Query: 722 VHIRGGKQRE-------TPLHIAARIPDGDKCAL-MLLKSGAGPNKATEDGMTPVHVAAK 773
V + G+ ++ TPLH+AA+ +G + + LL++G N+ T+ G T +H AA
Sbjct: 174 VALLEGEAKDPCDPNYTTPLHLAAK--NGHREVIRQLLRAGIEINRQTKTG-TALHEAAL 230
Query: 774 FGNLATLVLLLEDGGD 789
+G + LLLE G D
Sbjct: 231 YGKTEVVRLLLEGGVD 246
Score = 54.8 bits (126), Expect = 3e-06
Identities = 31/93 (33%), Positives = 47/93 (50%)
Query: 1310 DRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESG 1369
D G + LH A+ G +++ +LL A ++ D NG PLH AA G L V+LL +
Sbjct: 46 DADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRAS 105
Query: 1370 ASPKSETNLNCAPIWFAASENHNDVLEYLLHKE 1402
A+ + + P+ AA H +V E LL +
Sbjct: 106 AAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQ 138
Score = 52.4 bits (120), Expect = 2e-05
Identities = 61/233 (26%), Positives = 103/233 (44%), Gaps = 23/233 (9%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y+ DG ++H AA G + +I LL+ +VD+ ++ LH A + V LL
Sbjct: 44 YQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLR 103
Query: 718 YGADVHIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
A V+ + PLH+AA+ + + MLL+ + P + TP+ +A +FG L
Sbjct: 104 ASAAVN-AASLDGQIPLHLAAQYGHYE-VSEMLLQHQSNPCLVNKAKKTPLDLACEFGRL 161
Query: 778 ATLVLLLEDG-GDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVS 836
LLL L + + TPL +A ++ +++R L+ +
Sbjct: 162 KVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLR----------A 211
Query: 837 TAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHN 889
I+ + G +ALH A K E VV+ L+E G DV+++ +N
Sbjct: 212 GIEINRQTKTG-TALHEAALYGKTE---------VVRLLLEGGVDVNIRNTYN 254
Score = 52.4 bits (120), Expect = 2e-05
Identities = 32/88 (36%), Positives = 51/88 (57%), Gaps = 4/88 (4%)
Query: 98 GDTALHLAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANA 157
G +ALH AA +++ +L++ A VD + G PLH AA +G V+ +RA+A
Sbjct: 49 GFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLL--LRASA 106
Query: 158 AI--ADNEDRTPMHLAAENGHAAIIELL 183
A+ A + + P+HLAA+ GH + E+L
Sbjct: 107 AVNAASLDGQIPLHLAAQYGHYEVSEML 134
Score = 43.6 bits (98), Expect = 0.008
Identities = 27/96 (28%), Positives = 45/96 (46%), Gaps = 1/96 (1%)
Query: 124 VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELL 183
V+ + G + LH AA G L+ +A I D+ P+H AA G + LL
Sbjct: 42 VNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLL 101
Query: 184 ADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFK 219
+ A++ + DG +H+A+ GH + + ML +
Sbjct: 102 L-RASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQ 136
Score = 39.1 bits (87), Expect = 0.17
Identities = 26/72 (36%), Positives = 40/72 (55%), Gaps = 3/72 (4%)
Query: 66 PLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
PL LA + G++ ++R+LL A ++ T G TALH AA ++ R+L++ G V+
Sbjct: 192 PLHLAAKNGHREVIRQLLRAGI--EINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVN 248
Query: 126 ATNGAGQTPLHI 137
N QT L I
Sbjct: 249 IRNTYNQTALDI 260
>AK095193-1|BAC04496.1| 389|Homo sapiens protein ( Homo sapiens cDNA
FLJ37874 fis, clone BRSSN2018731, weakly similar to
ANKYRIN 1. ).
Length = 389
Score = 93.5 bits (222), Expect = 7e-18
Identities = 82/305 (26%), Positives = 133/305 (43%), Gaps = 17/305 (5%)
Query: 1066 IHAAAQNNYSEVVQL-FLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVI 1124
+ A SE+V L +L H + T G T +HIAAI+G ++ L+ G
Sbjct: 34 VRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIM---NGAN 90
Query: 1125 SARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
TPL LAA GH+ +++++R+G + ++ VH AA HG L ++
Sbjct: 91 LTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLL 150
Query: 1185 RSTNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGA--E 1242
G P+H+AA G + L+S + S VL A +
Sbjct: 151 VKWGCGIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMS-----------SATQVLKAFND 199
Query: 1243 SGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRS 1302
+G L LA +N+++ + + D E P H+A F G + ++ L+
Sbjct: 200 NGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDG 259
Query: 1303 AELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVV 1362
++ +G T +H A+ GH + ++ L+ GA+ N T+K G P A + HL V
Sbjct: 260 VININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAV 319
Query: 1363 KLLCE 1367
KLL E
Sbjct: 320 KLLEE 324
Score = 81.0 bits (191), Expect = 4e-14
Identities = 70/241 (29%), Positives = 112/241 (46%), Gaps = 17/241 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRIS 1193
T +AA G V+ L+ GA+ T ++ G T +HLAA HGH+ L +M +
Sbjct: 67 TASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSV 126
Query: 1194 SKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAY 1253
+ K P+H AA++G+ ++ L+ G + V +G P+HLAA
Sbjct: 127 TDKREWRPVHYAAFHGRLGCLQLLVKW-----------GCGIEDV--DYNGNLPVHLAAM 173
Query: 1254 NGNENVVRLLLN--SAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDR 1311
G+ + + L++ S+ Q A N+NG N L LA +I+ + E D+
Sbjct: 174 EGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGAEYEGKDLEDQ 233
Query: 1312 HGKTGL-HIASTHGHYQMVEVLLGQGA-EINATDKNGWTPLHCAAKAGHLNVVKLLCESG 1369
H+A+ G M++ L+ G IN NG TP+H AA GH+ ++ L + G
Sbjct: 234 ETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMG 293
Query: 1370 A 1370
A
Sbjct: 294 A 294
Score = 74.1 bits (174), Expect = 5e-12
Identities = 40/123 (32%), Positives = 62/123 (50%), Gaps = 1/123 (0%)
Query: 1279 GYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAE 1338
G+ H+A G + V L+ A L DR G T LH+A+THGH ++++L G +
Sbjct: 65 GWTASHIAAIRGQDACVQALIMNGANLTAQDDR-GCTPLHLAATHGHSFTLQIMLRSGVD 123
Query: 1339 INATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYL 1398
+ TDK W P+H AA G L ++LL + G + P+ AA E H ++L
Sbjct: 124 PSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCGIEDVDYNGNLPVHLAAMEGHLHCFKFL 183
Query: 1399 LHK 1401
+ +
Sbjct: 184 VSR 186
Score = 70.1 bits (164), Expect = 8e-11
Identities = 80/310 (25%), Positives = 126/310 (40%), Gaps = 20/310 (6%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L+ +GAD++ T TA H AI G + + +I + + L Q+ G TPL
Sbjct: 51 LLWHGADITHVTTRGW-TASHIAAIRGQDACVQALIMNGAN------LTAQDDRGCTPLH 103
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
+A GH + +L + V D +H AA HG L L+ I N
Sbjct: 104 LAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCGIEDVDYN 163
Query: 995 GRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTL---KKQTPLHLAAASGQIEVCKLLLEL 1051
G +HLAAM G+ H KFL+ ++ VL + L LA + + + +
Sbjct: 164 GNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFI--Q 221
Query: 1052 GANIDATDELGQK----PIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQG 1107
GA + D Q+ P H AA +++ ++ + +G+T H AA QG
Sbjct: 222 GAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQG 281
Query: 1108 SVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGA-SCTDENRAGL 1166
++ ++ L+K I+ NK + P +A H V++L DEN
Sbjct: 282 HIECLQWLIKMGADSNIT--NKAGE-RPSDVAKRFAHLAAVKLLEELQKYDIDDENEIDE 338
Query: 1167 TAVHLAAEHG 1176
V HG
Sbjct: 339 NDVKYFIRHG 348
Score = 63.7 bits (148), Expect = 7e-09
Identities = 42/155 (27%), Positives = 72/155 (46%), Gaps = 5/155 (3%)
Query: 70 AVEAGNQSMVRELLSAQT----AEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVD 125
AV AG+ + E++ + T G TA H+AA R + L+ GA +
Sbjct: 33 AVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLT 92
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
A + G TPLH+AA G ++ + ++ D + P+H AA +G ++LL
Sbjct: 93 AQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLV- 151
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
K+ I + +G+ +H+A++ GH C L +
Sbjct: 152 KWGCGIEDVDYNGNLPVHLAAMEGHLHCFKFLVSR 186
Score = 55.2 bits (127), Expect = 2e-06
Identities = 79/318 (24%), Positives = 135/318 (42%), Gaps = 38/318 (11%)
Query: 666 SIHTAARYGHVG------IINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYG 719
SIH A R G V ++ LL G + T +TA HIA + A V+ L+ G
Sbjct: 29 SIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNG 88
Query: 720 ADVHIRGGKQRETPLHIAARIPDGDKCAL-MLLKSGAGPNKATEDGMTPVHVAAKFGNLA 778
A++ + + TPLH+AA G L ++L+SG P+ + PVH AA G L
Sbjct: 89 ANLTAQDDRGC-TPLHLAAT--HGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLG 145
Query: 779 TLVLLLEDGGDPLRKTKVCIYDV-VTGETPLQMACRSCMPDIVRHLIEFVKDHKGESVST 837
L LL++ G I DV G P+ +A + H +F+ S +T
Sbjct: 146 CLQLLVKWG--------CGIEDVDYNGNLPVHLAAM----EGHLHCFKFLVSRM--SSAT 191
Query: 838 AFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSLQTRHNHETAFHYC 897
+ A +++G + L A + K+ + Q ++ G D L+ + H
Sbjct: 192 QVLKAFNDNGENVLDLAQRFFKQNI------LQFIQGAEYEGKD--LEDQETLAFPGHVA 243
Query: 898 AIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDV 957
A G+ ++ +++ D +N + G TP+ A +GH++ + L+ A ++
Sbjct: 244 AFKGDLGMLKKLV-----EDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNI 298
Query: 958 FDVEGRSALHLAAEHGYL 975
+ G +A +L
Sbjct: 299 TNKAGERPSDVAKRFAHL 316
Score = 53.6 bits (123), Expect = 7e-06
Identities = 38/142 (26%), Positives = 67/142 (47%), Gaps = 6/142 (4%)
Query: 98 GDTALHLAARRRDVDMARILVDYGA----VVDATNGAGQTPLHIAAAEGDEPLVKYFYGV 153
G+ +HLAA + + LV + V+ A N G+ L +A + ++++ G
Sbjct: 164 GNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQGA 223
Query: 154 RANAAIADNEDRT--PMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHA 211
++++ P H+AA G +++ L + +I ER +GST MH A+ GH
Sbjct: 224 EYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHI 283
Query: 212 DCAMMLFKKGVYLHMPNKYFEK 233
+C L K G ++ NK E+
Sbjct: 284 ECLQWLIKMGADSNITNKAGER 305
Score = 46.8 bits (106), Expect = 8e-04
Identities = 27/82 (32%), Positives = 40/82 (48%), Gaps = 2/82 (2%)
Query: 1332 LLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENH 1391
LL GA+I GWT H AA G V+ L +GA+ ++ + C P+ AA+ H
Sbjct: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
Query: 1392 NDVLEYLLHKEHDTQSLMDDKR 1413
+ L+ +L D + DKR
Sbjct: 111 SFTLQIMLRSGVDPS--VTDKR 130
Score = 44.8 bits (101), Expect = 0.003
Identities = 32/115 (27%), Positives = 50/115 (43%), Gaps = 2/115 (1%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G + H AA G + L+ G ++ + T LH+A ++ +L G D
Sbjct: 65 GWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDP 124
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNL 777
+ K+ P+H AA C +L+K G G +G PVH+AA G+L
Sbjct: 125 SVT-DKREWRPVHYAA-FHGRLGCLQLLVKWGCGIEDVDYNGNLPVHLAAMEGHL 177
Score = 43.2 bits (97), Expect = 0.010
Identities = 25/90 (27%), Positives = 46/90 (51%), Gaps = 1/90 (1%)
Query: 103 HLAARRRDVDMARILVDYGAV-VDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIAD 161
H+AA + D+ M + LV+ G + ++ G TP+H AA +G +++ + A++ I +
Sbjct: 241 HVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITN 300
Query: 162 NEDRTPMHLAAENGHAAIIELLADKFKASI 191
P +A H A ++LL + K I
Sbjct: 301 KAGERPSDVAKRFAHLAAVKLLEELQKYDI 330
Score = 39.1 bits (87), Expect = 0.17
Identities = 33/132 (25%), Positives = 49/132 (37%), Gaps = 2/132 (1%)
Query: 59 VFQRGKVPLLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILV 118
V RG +A G + V+ L+ L A G T LHLAA +I++
Sbjct: 61 VTTRGWTASHIAAIRGQDACVQALI--MNGANLTAQDDRGCTPLHLAATHGHSFTLQIML 118
Query: 119 DYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAA 178
G T+ P+H AA G ++ D P+HLAA GH
Sbjct: 119 RSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCGIEDVDYNGNLPVHLAAMEGHLH 178
Query: 179 IIELLADKFKAS 190
+ L + ++
Sbjct: 179 CFKFLVSRMSSA 190
>DQ309791-1|ABC48694.1| 871|Homo sapiens SamCystin protein.
Length = 871
Score = 91.9 bits (218), Expect = 2e-17
Identities = 87/318 (27%), Positives = 140/318 (44%), Gaps = 9/318 (2%)
Query: 1133 STPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
+T LQ AA GGH +VR L+R GAS N G +A+ AA GH +V ++
Sbjct: 79 NTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVN 138
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG--VSLVPVLGAESGLTPLHL 1250
+ +LG + L +A+ G V+ LL V P+G + L +T L
Sbjct: 139 AQNRLGASVLTVASRGGHLGVVK-LLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMA 197
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
A +G+E VVRLL+ G + A+ G++PL LA G + + L+ + A H +
Sbjct: 198 AIQHGHEAVVRLLM-EWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSV 256
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP-LHCAAKAGHLNVVKLLCESG 1369
KT +A H +V+ L TD+ P + A K G+ +VK + +
Sbjct: 257 LE-KTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADED 315
Query: 1370 ASPKSETNLNCA-PIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNI 1428
S + N + A P+ AA +++ L+ + D D + ++ + H N
Sbjct: 316 PSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDK--QDSVHGWTALMQATYHGNK 373
Query: 1429 PIEEFVLVSPAPVDTAAK 1446
I +++L A V AK
Sbjct: 374 EIVKYLLNQGADVTLRAK 391
Score = 83.0 bits (196), Expect = 1e-14
Identities = 88/330 (26%), Positives = 144/330 (43%), Gaps = 26/330 (7%)
Query: 1031 TPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVM 1090
T L AAA G + + LL GA++++ + G + AA+ + V L L H V
Sbjct: 80 TALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLD-HGADVN 138
Query: 1091 ATTKDGNTCAHIAAIQGSVKVIEELMKF-----------DRTGVISARNKLNDSTPLQLA 1139
A + G + +A+ G + V++ L++ ++ G+ +R++ D T L A
Sbjct: 139 AQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAA 198
Query: 1140 AEGGHADVVRVLVRAGASCTDENRA-GLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLG 1198
+ GH VVR+L+ GA R G + + LAA G V + + G
Sbjct: 199 IQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQL----------VEKG 248
Query: 1199 LTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNEN 1258
P H++ A V H + T V P E + A GN
Sbjct: 249 ANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVR--PKTDEEKRRPDIFHALKMGNFQ 306
Query: 1259 VVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH 1318
+V+ + + + N +G PL LA G +++V LL+ R A++ HG T L
Sbjct: 307 LVKEIADEDPSHVNLV-NGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALM 365
Query: 1319 IASTHGHYQMVEVLLGQGAEINATDKNGWT 1348
A+ HG+ ++V+ LL QGA++ KNG+T
Sbjct: 366 QATYHGNKEIVKYLLNQGADVTLRAKNGYT 395
Score = 73.3 bits (172), Expect = 8e-12
Identities = 75/309 (24%), Positives = 135/309 (43%), Gaps = 19/309 (6%)
Query: 921 ALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDA 980
++N +N GW+ L+ A GH+ + + LL + A V+ + G S L +A+ G+L V
Sbjct: 103 SVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKL 162
Query: 981 LLTNKAFINSKARNGR--------------TALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
LL AF++ +G TAL A +G+ +V+ L+
Sbjct: 163 LLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAAR 222
Query: 1027 LKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP 1086
+PL LAA +G++ V + L+E GAN D L + A + ++V +L
Sbjct: 223 TVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVD-YLDPLT 281
Query: 1087 NLVMATTKDGNTCAHIAAIQ-GSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA 1145
+ T ++ A++ G+ ++++E+ D + V + +TPL LAA G
Sbjct: 282 TVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNG--DGATPLMLAAVTGQL 339
Query: 1146 DVVRVLVRAGASCTDENRA-GLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHI 1204
+V++LV A ++ G TA+ A HG+ ++ + + K G T +
Sbjct: 340 ALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDL 399
Query: 1205 AAYYGQAET 1213
+T
Sbjct: 400 VMLLNDPDT 408
Score = 71.3 bits (167), Expect = 3e-11
Identities = 39/96 (40%), Positives = 57/96 (59%), Gaps = 1/96 (1%)
Query: 1275 SNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG 1334
S+E G L A GGH +V LL R A + +S + +G + L A+ GH + +LL
Sbjct: 74 SDEAGNTALQFAAAGGHEPLVRFLLRRGASV-NSRNHYGWSALMQAARFGHVSVAHLLLD 132
Query: 1335 QGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
GA++NA ++ G + L A++ GHL VVKLL E+GA
Sbjct: 133 HGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGA 168
Score = 68.9 bits (161), Expect = 2e-10
Identities = 96/361 (26%), Positives = 156/361 (43%), Gaps = 55/361 (15%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA GH ++ LL++G SV+ + ++AL A +V LL +GADV
Sbjct: 78 GNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADV 137
Query: 723 HIRGGKQRETPLHIAARIPDGDKCAL--MLLKSGA--------------GPNKATEDGMT 766
+ + + + L +A+R G + +LL++GA G ++ +T
Sbjct: 138 NAQ-NRLGASVLTVASR---GGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDIT 193
Query: 767 PVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIE- 825
+ A + G+ A + LL+E G DP + G +PL +A + + + L+E
Sbjct: 194 ALMAAIQHGHEAVVRLLMEWGADPNHAAR------TVGWSPLMLAALTGRLGVAQQLVEK 247
Query: 826 -FVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSL 884
DH TAF A+D + Y +T P D + + D+
Sbjct: 248 GANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVR---PKTDEE------KRRPDI-- 296
Query: 885 QTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQL 944
FH + GN +++ I+ D S +N N G TPL++A G + L
Sbjct: 297 ---------FHALKM-GN----FQLVKEIADEDPSH-VNLVNGDGATPLMLAAVTGQLAL 341
Query: 945 VNTLLTNHARVDVFD-VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAA 1003
V L+ HA VD D V G +AL A HG ++ LL A + +A+NG TA L
Sbjct: 342 VQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVM 401
Query: 1004 M 1004
+
Sbjct: 402 L 402
Score = 66.5 bits (155), Expect = 1e-09
Identities = 94/360 (26%), Positives = 155/360 (43%), Gaps = 41/360 (11%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G T L A GH LV LL A V+ + G SAL AA G++ V LL + A +
Sbjct: 78 GNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADV 137
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N++ R G + L +A+ G+ +VK L+ + A +D H + Q
Sbjct: 138 NAQNRLGASVLTVASRGGHLGVVKLLL-EAGAFVD----------HHHPSGEQ------- 179
Query: 1049 LELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGS 1108
L LG + D + L + AA Q+ + VV+L ++ + A G + +AA+ G
Sbjct: 180 LGLGGSRD--EPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGR 237
Query: 1109 VKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL--VRAGASCTDENRAGL 1166
+ V ++L++ G + + T ++A + H D+V L + TDE +
Sbjct: 238 LGVAQQLVE---KGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRP 294
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRIS-SKKLGLTPLHIAAYYGQAETVRELLSHVPGTV 1225
H A + G+ ++ + + ++ G TPL +AA GQ V+ L+
Sbjct: 295 DIFH-ALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVD 353
Query: 1226 KSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHL 1285
K + + G T L A Y+GN+ +V+ LLN G + +NGY L
Sbjct: 354 KQD------------SVHGWTALMQATYHGNKEIVKYLLNQ-GADVTLRA-KNGYTAFDL 399
Score = 63.3 bits (147), Expect = 9e-09
Identities = 48/164 (29%), Positives = 72/164 (43%), Gaps = 8/164 (4%)
Query: 1242 ESGLTP-----LHLAAYNGNENVVRLLLNSAGVQAD-AASNENGYNPLHLACFGGHMSIV 1295
E GL P L E RLL A A+ A E G P G +
Sbjct: 3 EGGLPPAFQLLLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAA 62
Query: 1296 GLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAK 1355
G + + + +D G T L A+ GH +V LL +GA +N+ + GW+ L AA+
Sbjct: 63 GAV--GAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAAR 120
Query: 1356 AGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
GH++V LL + GA ++ L + + A+ H V++ LL
Sbjct: 121 FGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLL 164
Score = 56.4 bits (130), Expect = 1e-06
Identities = 74/310 (23%), Positives = 126/310 (40%), Gaps = 24/310 (7%)
Query: 750 LLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQ 809
LL+ GA N G + + AA+FG+++ LLL+ G D + ++ G + L
Sbjct: 97 LLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNRL-------GASVLT 149
Query: 810 MACRSCMPDIVRHLIE---FVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPT 866
+A R +V+ L+E FV H + DE +T I
Sbjct: 150 VASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDE--------PLDITALMAAIQH 201
Query: 867 ADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQN 926
VV+ L+E GAD + R + A+ G V +++ + D L +
Sbjct: 202 GHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEK-- 259
Query: 927 SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALL-TNK 985
+ L HR + ++ L T + D + + R + A + G Q+ + +
Sbjct: 260 -TAFEVALDCKHRDLVDYLDPLTTVRPKTD--EEKRRPDIFHALKMGNFQLVKEIADEDP 316
Query: 986 AFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVC 1045
+ +N +G T L LAA+ G LV+ L+ H + ++ T L A G E+
Sbjct: 317 SHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIV 376
Query: 1046 KLLLELGANI 1055
K LL GA++
Sbjct: 377 KYLLNQGADV 386
Score = 56.4 bits (130), Expect = 1e-06
Identities = 88/306 (28%), Positives = 128/306 (41%), Gaps = 47/306 (15%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA-- 720
G ++ AAR+GHV + + LL G V+ + L +A VV+ LL GA
Sbjct: 111 GWSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFV 170
Query: 721 DVHIRGGKQ------RETPLHIA---ARIPDGDKCAL-MLLKSGAGPNKATED-GMTPVH 769
D H G+Q R+ PL I A I G + + +L++ GA PN A G +P+
Sbjct: 171 DHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLM 230
Query: 770 VAAKFGNLATLVLLLEDGGDP-----LRKTKV-----CIY-DVVTGETPLQMAC-----R 813
+AA G L L+E G +P L KT C + D+V PL
Sbjct: 231 LAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEE 290
Query: 814 SCMPDIVRHL----IEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADR 869
PDI L + VK+ E S ++ V+ DGA+ L A T
Sbjct: 291 KRRPDIFHALKMGNFQLVKEIADEDPS--HVNLVNGDGATPLMLAA---------VTGQL 339
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVS-RALNRQNSI 928
+V+ L+E ADV Q + TA GN +++ ++ ADV+ RA N +
Sbjct: 340 ALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLN--QGADVTLRAKNGYTAF 397
Query: 929 GWTPLL 934
LL
Sbjct: 398 DLVMLL 403
Score = 54.0 bits (124), Expect = 5e-06
Identities = 45/165 (27%), Positives = 72/165 (43%), Gaps = 4/165 (2%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI-LVDYGAVVD 125
LL A + G+ R LL AE + A A A V VD
Sbjct: 13 LLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVPVD 72
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
++ AG T L AAA G EPLV++ A+ ++ + + AA GH ++ LL D
Sbjct: 73 CSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLD 132
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL--HMPN 228
A + + + G++++ +AS GH +L + G ++ H P+
Sbjct: 133 -HGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPS 176
Score = 44.8 bits (101), Expect = 0.003
Identities = 39/155 (25%), Positives = 74/155 (47%), Gaps = 2/155 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L+ A++ G++++VR LL A+ A G + L LAA + +A+ LV+ GA D
Sbjct: 195 LMAAIQHGHEAVVR-LLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDH 253
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTP-MHLAAENGHAAIIELLAD 185
+ +T +A LV Y + D E R P + A + G+ +++ +AD
Sbjct: 254 LSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIAD 313
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+ + + DG+T + +A++ G +L ++
Sbjct: 314 EDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVER 348
Score = 36.3 bits (80), Expect = 1.2
Identities = 27/110 (24%), Positives = 48/110 (43%), Gaps = 3/110 (2%)
Query: 1333 LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHN 1392
+G ++ +D+ G T L AA GH +V+ L GAS S + + + AA H
Sbjct: 65 VGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHV 124
Query: 1393 DVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVD 1442
V LL D + R +++ + ++ + + +L + A VD
Sbjct: 125 SVAHLLLDHGADVNA---QNRLGASVLTVASRGGHLGVVKLLLEAGAFVD 171
Score = 35.9 bits (79), Expect = 1.6
Identities = 28/93 (30%), Positives = 43/93 (46%), Gaps = 2/93 (2%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTN-DNYTALHIAVESCKPAVVETLLGYGA 720
DGA + AA G + ++ L+++ VD + +TAL A +V+ LL GA
Sbjct: 325 DGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGA 384
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKS 753
DV +R K T + + D D + LL S
Sbjct: 385 DVTLR-AKNGYTAFDLVMLLNDPDTELVRLLAS 416
Score = 33.5 bits (73), Expect = 8.3
Identities = 59/277 (21%), Positives = 108/277 (38%), Gaps = 24/277 (8%)
Query: 63 GKVPLLLAVEAGNQSMVRELLS-AQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
G PL+LA G + ++L+ + L TA +A + D+ L
Sbjct: 225 GWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEK---TAFEVALDCKHRDLVDYLDPLT 281
Query: 122 AVVDATNGAGQTP-LHIAAAEGDEPLVKYFYGVR-ANAAIADNEDRTPMHLAAENGHAAI 179
V T+ + P + A G+ LVK ++ + + + TP+ LAA G A+
Sbjct: 282 TVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLAL 341
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG--VYLHMPNKYFEKQTFD 237
++LL ++ + + G T + A+ +G+ + L +G V L N Y FD
Sbjct: 342 VQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGY---TAFD 398
Query: 238 EVLFVKIENGLIKGLKSDDGSYSMFLGIPYALVNESNPFGDSLPTLPFNEIYEAFDDSTA 297
V+ L D L VN+ P LP +++ + +
Sbjct: 399 LVML----------LNDPDTELVRLLASVCMQVNKDKGRPSHQPPLPHSKVRQPWSIPVL 448
Query: 298 CPQK---EEFNNTIVGEMQCLRLNIYVPKSLNNNLPV 331
K + + N + + L+L +P+ L++N P+
Sbjct: 449 PDDKGGLKSWWNRMSNRFRKLKLMQTLPRGLSSNQPL 485
>AL807776-3|CAM13062.1| 871|Homo sapiens ankyrin repeat and sterile
alpha motif domain containing 6 protein.
Length = 871
Score = 91.9 bits (218), Expect = 2e-17
Identities = 87/318 (27%), Positives = 140/318 (44%), Gaps = 9/318 (2%)
Query: 1133 STPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
+T LQ AA GGH +VR L+R GAS N G +A+ AA GH +V ++
Sbjct: 79 NTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVN 138
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG--VSLVPVLGAESGLTPLHL 1250
+ +LG + L +A+ G V+ LL V P+G + L +T L
Sbjct: 139 AQNRLGASVLTVASRGGHLGVVK-LLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMA 197
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
A +G+E VVRLL+ G + A+ G++PL LA G + + L+ + A H +
Sbjct: 198 AIQHGHEAVVRLLM-EWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSV 256
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP-LHCAAKAGHLNVVKLLCESG 1369
KT +A H +V+ L TD+ P + A K G+ +VK + +
Sbjct: 257 LE-KTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADED 315
Query: 1370 ASPKSETNLNCA-PIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNI 1428
S + N + A P+ AA +++ L+ + D D + ++ + H N
Sbjct: 316 PSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDK--QDSVHGWTALMQATYHGNK 373
Query: 1429 PIEEFVLVSPAPVDTAAK 1446
I +++L A V AK
Sbjct: 374 EIVKYLLNQGADVTLRAK 391
Score = 83.0 bits (196), Expect = 1e-14
Identities = 88/330 (26%), Positives = 144/330 (43%), Gaps = 26/330 (7%)
Query: 1031 TPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVM 1090
T L AAA G + + LL GA++++ + G + AA+ + V L L H V
Sbjct: 80 TALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLD-HGADVN 138
Query: 1091 ATTKDGNTCAHIAAIQGSVKVIEELMKF-----------DRTGVISARNKLNDSTPLQLA 1139
A + G + +A+ G + V++ L++ ++ G+ +R++ D T L A
Sbjct: 139 AQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAA 198
Query: 1140 AEGGHADVVRVLVRAGASCTDENRA-GLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLG 1198
+ GH VVR+L+ GA R G + + LAA G V + + G
Sbjct: 199 IQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQL----------VEKG 248
Query: 1199 LTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNEN 1258
P H++ A V H + T V P E + A GN
Sbjct: 249 ANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVR--PKTDEEKRRPDIFHALKMGNFQ 306
Query: 1259 VVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH 1318
+V+ + + + N +G PL LA G +++V LL+ R A++ HG T L
Sbjct: 307 LVKEIADEDPSHVNLV-NGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALM 365
Query: 1319 IASTHGHYQMVEVLLGQGAEINATDKNGWT 1348
A+ HG+ ++V+ LL QGA++ KNG+T
Sbjct: 366 QATYHGNKEIVKYLLNQGADVTLRAKNGYT 395
Score = 73.3 bits (172), Expect = 8e-12
Identities = 75/309 (24%), Positives = 135/309 (43%), Gaps = 19/309 (6%)
Query: 921 ALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDA 980
++N +N GW+ L+ A GH+ + + LL + A V+ + G S L +A+ G+L V
Sbjct: 103 SVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKL 162
Query: 981 LLTNKAFINSKARNGR--------------TALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
LL AF++ +G TAL A +G+ +V+ L+
Sbjct: 163 LLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAAR 222
Query: 1027 LKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP 1086
+PL LAA +G++ V + L+E GAN D L + A + ++V +L
Sbjct: 223 TVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVD-YLDPLT 281
Query: 1087 NLVMATTKDGNTCAHIAAIQ-GSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA 1145
+ T ++ A++ G+ ++++E+ D + V + +TPL LAA G
Sbjct: 282 TVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNG--DGATPLMLAAVTGQL 339
Query: 1146 DVVRVLVRAGASCTDENRA-GLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHI 1204
+V++LV A ++ G TA+ A HG+ ++ + + K G T +
Sbjct: 340 ALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDL 399
Query: 1205 AAYYGQAET 1213
+T
Sbjct: 400 VMLLNDPDT 408
Score = 71.3 bits (167), Expect = 3e-11
Identities = 39/96 (40%), Positives = 57/96 (59%), Gaps = 1/96 (1%)
Query: 1275 SNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG 1334
S+E G L A GGH +V LL R A + +S + +G + L A+ GH + +LL
Sbjct: 74 SDEAGNTALQFAAAGGHEPLVRFLLRRGASV-NSRNHYGWSALMQAARFGHVSVAHLLLD 132
Query: 1335 QGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
GA++NA ++ G + L A++ GHL VVKLL E+GA
Sbjct: 133 HGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGA 168
Score = 68.9 bits (161), Expect = 2e-10
Identities = 96/361 (26%), Positives = 156/361 (43%), Gaps = 55/361 (15%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA GH ++ LL++G SV+ + ++AL A +V LL +GADV
Sbjct: 78 GNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADV 137
Query: 723 HIRGGKQRETPLHIAARIPDGDKCAL--MLLKSGA--------------GPNKATEDGMT 766
+ + + + L +A+R G + +LL++GA G ++ +T
Sbjct: 138 NAQ-NRLGASVLTVASR---GGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDIT 193
Query: 767 PVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIE- 825
+ A + G+ A + LL+E G DP + G +PL +A + + + L+E
Sbjct: 194 ALMAAIQHGHEAVVRLLMEWGADPNHAAR------TVGWSPLMLAALTGRLGVAQQLVEK 247
Query: 826 -FVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSL 884
DH TAF A+D + Y +T P D + + D+
Sbjct: 248 GANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVR---PKTDEE------KRRPDI-- 296
Query: 885 QTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQL 944
FH + GN +++ I+ D S +N N G TPL++A G + L
Sbjct: 297 ---------FHALKM-GN----FQLVKEIADEDPSH-VNLVNGDGATPLMLAAVTGQLAL 341
Query: 945 VNTLLTNHARVDVFD-VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAA 1003
V L+ HA VD D V G +AL A HG ++ LL A + +A+NG TA L
Sbjct: 342 VQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVM 401
Query: 1004 M 1004
+
Sbjct: 402 L 402
Score = 66.5 bits (155), Expect = 1e-09
Identities = 94/360 (26%), Positives = 155/360 (43%), Gaps = 41/360 (11%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G T L A GH LV LL A V+ + G SAL AA G++ V LL + A +
Sbjct: 78 GNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADV 137
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N++ R G + L +A+ G+ +VK L+ + A +D H + Q
Sbjct: 138 NAQNRLGASVLTVASRGGHLGVVKLLL-EAGAFVD----------HHHPSGEQ------- 179
Query: 1049 LELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGS 1108
L LG + D + L + AA Q+ + VV+L ++ + A G + +AA+ G
Sbjct: 180 LGLGGSRD--EPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGR 237
Query: 1109 VKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL--VRAGASCTDENRAGL 1166
+ V ++L++ G + + T ++A + H D+V L + TDE +
Sbjct: 238 LGVAQQLVE---KGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRP 294
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRIS-SKKLGLTPLHIAAYYGQAETVRELLSHVPGTV 1225
H A + G+ ++ + + ++ G TPL +AA GQ V+ L+
Sbjct: 295 DIFH-ALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVD 353
Query: 1226 KSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHL 1285
K + + G T L A Y+GN+ +V+ LLN G + +NGY L
Sbjct: 354 KQD------------SVHGWTALMQATYHGNKEIVKYLLNQ-GADVTLRA-KNGYTAFDL 399
Score = 63.3 bits (147), Expect = 9e-09
Identities = 48/164 (29%), Positives = 72/164 (43%), Gaps = 8/164 (4%)
Query: 1242 ESGLTP-----LHLAAYNGNENVVRLLLNSAGVQAD-AASNENGYNPLHLACFGGHMSIV 1295
E GL P L E RLL A A+ A E G P G +
Sbjct: 3 EGGLPPAFQLLLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAA 62
Query: 1296 GLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAK 1355
G + + + +D G T L A+ GH +V LL +GA +N+ + GW+ L AA+
Sbjct: 63 GAV--GAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAAR 120
Query: 1356 AGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
GH++V LL + GA ++ L + + A+ H V++ LL
Sbjct: 121 FGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLL 164
Score = 56.4 bits (130), Expect = 1e-06
Identities = 74/310 (23%), Positives = 126/310 (40%), Gaps = 24/310 (7%)
Query: 750 LLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQ 809
LL+ GA N G + + AA+FG+++ LLL+ G D + ++ G + L
Sbjct: 97 LLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNRL-------GASVLT 149
Query: 810 MACRSCMPDIVRHLIE---FVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPT 866
+A R +V+ L+E FV H + DE +T I
Sbjct: 150 VASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDE--------PLDITALMAAIQH 201
Query: 867 ADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQN 926
VV+ L+E GAD + R + A+ G V +++ + D L +
Sbjct: 202 GHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEK-- 259
Query: 927 SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALL-TNK 985
+ L HR + ++ L T + D + + R + A + G Q+ + +
Sbjct: 260 -TAFEVALDCKHRDLVDYLDPLTTVRPKTD--EEKRRPDIFHALKMGNFQLVKEIADEDP 316
Query: 986 AFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVC 1045
+ +N +G T L LAA+ G LV+ L+ H + ++ T L A G E+
Sbjct: 317 SHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIV 376
Query: 1046 KLLLELGANI 1055
K LL GA++
Sbjct: 377 KYLLNQGADV 386
Score = 56.4 bits (130), Expect = 1e-06
Identities = 88/306 (28%), Positives = 128/306 (41%), Gaps = 47/306 (15%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA-- 720
G ++ AAR+GHV + + LL G V+ + L +A VV+ LL GA
Sbjct: 111 GWSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFV 170
Query: 721 DVHIRGGKQ------RETPLHIA---ARIPDGDKCAL-MLLKSGAGPNKATED-GMTPVH 769
D H G+Q R+ PL I A I G + + +L++ GA PN A G +P+
Sbjct: 171 DHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLM 230
Query: 770 VAAKFGNLATLVLLLEDGGDP-----LRKTKV-----CIY-DVVTGETPLQMAC-----R 813
+AA G L L+E G +P L KT C + D+V PL
Sbjct: 231 LAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEE 290
Query: 814 SCMPDIVRHL----IEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADR 869
PDI L + VK+ E S ++ V+ DGA+ L A T
Sbjct: 291 KRRPDIFHALKMGNFQLVKEIADEDPS--HVNLVNGDGATPLMLAA---------VTGQL 339
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVS-RALNRQNSI 928
+V+ L+E ADV Q + TA GN +++ ++ ADV+ RA N +
Sbjct: 340 ALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLN--QGADVTLRAKNGYTAF 397
Query: 929 GWTPLL 934
LL
Sbjct: 398 DLVMLL 403
Score = 54.0 bits (124), Expect = 5e-06
Identities = 45/165 (27%), Positives = 72/165 (43%), Gaps = 4/165 (2%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI-LVDYGAVVD 125
LL A + G+ R LL AE + A A A V VD
Sbjct: 13 LLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVPVD 72
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
++ AG T L AAA G EPLV++ A+ ++ + + AA GH ++ LL D
Sbjct: 73 CSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLD 132
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL--HMPN 228
A + + + G++++ +AS GH +L + G ++ H P+
Sbjct: 133 -HGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPS 176
Score = 44.8 bits (101), Expect = 0.003
Identities = 39/155 (25%), Positives = 74/155 (47%), Gaps = 2/155 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L+ A++ G++++VR LL A+ A G + L LAA + +A+ LV+ GA D
Sbjct: 195 LMAAIQHGHEAVVR-LLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDH 253
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTP-MHLAAENGHAAIIELLAD 185
+ +T +A LV Y + D E R P + A + G+ +++ +AD
Sbjct: 254 LSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIAD 313
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+ + + DG+T + +A++ G +L ++
Sbjct: 314 EDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVER 348
Score = 36.3 bits (80), Expect = 1.2
Identities = 27/110 (24%), Positives = 48/110 (43%), Gaps = 3/110 (2%)
Query: 1333 LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHN 1392
+G ++ +D+ G T L AA GH +V+ L GAS S + + + AA H
Sbjct: 65 VGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHV 124
Query: 1393 DVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVD 1442
V LL D + R +++ + ++ + + +L + A VD
Sbjct: 125 SVAHLLLDHGADVNA---QNRLGASVLTVASRGGHLGVVKLLLEAGAFVD 171
Score = 35.9 bits (79), Expect = 1.6
Identities = 28/93 (30%), Positives = 43/93 (46%), Gaps = 2/93 (2%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTN-DNYTALHIAVESCKPAVVETLLGYGA 720
DGA + AA G + ++ L+++ VD + +TAL A +V+ LL GA
Sbjct: 325 DGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGA 384
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKS 753
DV +R K T + + D D + LL S
Sbjct: 385 DVTLR-AKNGYTAFDLVMLLNDPDTELVRLLAS 416
Score = 33.5 bits (73), Expect = 8.3
Identities = 59/277 (21%), Positives = 108/277 (38%), Gaps = 24/277 (8%)
Query: 63 GKVPLLLAVEAGNQSMVRELLS-AQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
G PL+LA G + ++L+ + L TA +A + D+ L
Sbjct: 225 GWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEK---TAFEVALDCKHRDLVDYLDPLT 281
Query: 122 AVVDATNGAGQTP-LHIAAAEGDEPLVKYFYGVR-ANAAIADNEDRTPMHLAAENGHAAI 179
V T+ + P + A G+ LVK ++ + + + TP+ LAA G A+
Sbjct: 282 TVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLAL 341
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG--VYLHMPNKYFEKQTFD 237
++LL ++ + + G T + A+ +G+ + L +G V L N Y FD
Sbjct: 342 VQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGY---TAFD 398
Query: 238 EVLFVKIENGLIKGLKSDDGSYSMFLGIPYALVNESNPFGDSLPTLPFNEIYEAFDDSTA 297
V+ L D L VN+ P LP +++ + +
Sbjct: 399 LVML----------LNDPDTELVRLLASVCMQVNKDKGRPSHQPPLPHSKVRQPWSIPVL 448
Query: 298 CPQK---EEFNNTIVGEMQCLRLNIYVPKSLNNNLPV 331
K + + N + + L+L +P+ L++N P+
Sbjct: 449 PDDKGGLKSWWNRMSNRFRKLKLMQTLPRGLSSNQPL 485
>AL353782-4|CAM14169.1| 871|Homo sapiens ankyrin repeat and sterile
alpha motif domain containing 6 protein.
Length = 871
Score = 91.9 bits (218), Expect = 2e-17
Identities = 87/318 (27%), Positives = 140/318 (44%), Gaps = 9/318 (2%)
Query: 1133 STPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
+T LQ AA GGH +VR L+R GAS N G +A+ AA GH +V ++
Sbjct: 79 NTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVN 138
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTG--VSLVPVLGAESGLTPLHL 1250
+ +LG + L +A+ G V+ LL V P+G + L +T L
Sbjct: 139 AQNRLGASVLTVASRGGHLGVVK-LLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMA 197
Query: 1251 AAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTD 1310
A +G+E VVRLL+ G + A+ G++PL LA G + + L+ + A H +
Sbjct: 198 AIQHGHEAVVRLLM-EWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSV 256
Query: 1311 RHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTP-LHCAAKAGHLNVVKLLCESG 1369
KT +A H +V+ L TD+ P + A K G+ +VK + +
Sbjct: 257 LE-KTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADED 315
Query: 1370 ASPKSETNLNCA-PIWFAASENHNDVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNI 1428
S + N + A P+ AA +++ L+ + D D + ++ + H N
Sbjct: 316 PSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDK--QDSVHGWTALMQATYHGNK 373
Query: 1429 PIEEFVLVSPAPVDTAAK 1446
I +++L A V AK
Sbjct: 374 EIVKYLLNQGADVTLRAK 391
Score = 83.0 bits (196), Expect = 1e-14
Identities = 88/330 (26%), Positives = 144/330 (43%), Gaps = 26/330 (7%)
Query: 1031 TPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVM 1090
T L AAA G + + LL GA++++ + G + AA+ + V L L H V
Sbjct: 80 TALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLD-HGADVN 138
Query: 1091 ATTKDGNTCAHIAAIQGSVKVIEELMKF-----------DRTGVISARNKLNDSTPLQLA 1139
A + G + +A+ G + V++ L++ ++ G+ +R++ D T L A
Sbjct: 139 AQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAA 198
Query: 1140 AEGGHADVVRVLVRAGASCTDENRA-GLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLG 1198
+ GH VVR+L+ GA R G + + LAA G V + + G
Sbjct: 199 IQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQL----------VEKG 248
Query: 1199 LTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAAYNGNEN 1258
P H++ A V H + T V P E + A GN
Sbjct: 249 ANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVR--PKTDEEKRRPDIFHALKMGNFQ 306
Query: 1259 VVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLH 1318
+V+ + + + N +G PL LA G +++V LL+ R A++ HG T L
Sbjct: 307 LVKEIADEDPSHVNLV-NGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALM 365
Query: 1319 IASTHGHYQMVEVLLGQGAEINATDKNGWT 1348
A+ HG+ ++V+ LL QGA++ KNG+T
Sbjct: 366 QATYHGNKEIVKYLLNQGADVTLRAKNGYT 395
Score = 73.3 bits (172), Expect = 8e-12
Identities = 75/309 (24%), Positives = 135/309 (43%), Gaps = 19/309 (6%)
Query: 921 ALNRQNSIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDA 980
++N +N GW+ L+ A GH+ + + LL + A V+ + G S L +A+ G+L V
Sbjct: 103 SVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKL 162
Query: 981 LLTNKAFINSKARNGR--------------TALHLAAMNGYAHLVKFLIRDHNAMIDVLT 1026
LL AF++ +G TAL A +G+ +V+ L+
Sbjct: 163 LLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAAR 222
Query: 1027 LKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP 1086
+PL LAA +G++ V + L+E GAN D L + A + ++V +L
Sbjct: 223 TVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVD-YLDPLT 281
Query: 1087 NLVMATTKDGNTCAHIAAIQ-GSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHA 1145
+ T ++ A++ G+ ++++E+ D + V + +TPL LAA G
Sbjct: 282 TVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNG--DGATPLMLAAVTGQL 339
Query: 1146 DVVRVLVRAGASCTDENRA-GLTAVHLAAEHGHTNVLDVMRSTNTLRISSKKLGLTPLHI 1204
+V++LV A ++ G TA+ A HG+ ++ + + K G T +
Sbjct: 340 ALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDL 399
Query: 1205 AAYYGQAET 1213
+T
Sbjct: 400 VMLLNDPDT 408
Score = 71.3 bits (167), Expect = 3e-11
Identities = 39/96 (40%), Positives = 57/96 (59%), Gaps = 1/96 (1%)
Query: 1275 SNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLG 1334
S+E G L A GGH +V LL R A + +S + +G + L A+ GH + +LL
Sbjct: 74 SDEAGNTALQFAAAGGHEPLVRFLLRRGASV-NSRNHYGWSALMQAARFGHVSVAHLLLD 132
Query: 1335 QGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGA 1370
GA++NA ++ G + L A++ GHL VVKLL E+GA
Sbjct: 133 HGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGA 168
Score = 68.9 bits (161), Expect = 2e-10
Identities = 96/361 (26%), Positives = 156/361 (43%), Gaps = 55/361 (15%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ AA GH ++ LL++G SV+ + ++AL A +V LL +GADV
Sbjct: 78 GNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADV 137
Query: 723 HIRGGKQRETPLHIAARIPDGDKCAL--MLLKSGA--------------GPNKATEDGMT 766
+ + + + L +A+R G + +LL++GA G ++ +T
Sbjct: 138 NAQ-NRLGASVLTVASR---GGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDIT 193
Query: 767 PVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQMACRSCMPDIVRHLIE- 825
+ A + G+ A + LL+E G DP + G +PL +A + + + L+E
Sbjct: 194 ALMAAIQHGHEAVVRLLMEWGADPNHAAR------TVGWSPLMLAALTGRLGVAQQLVEK 247
Query: 826 -FVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADRQVVKCLIENGADVSL 884
DH TAF A+D + Y +T P D + + D+
Sbjct: 248 GANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVR---PKTDEE------KRRPDI-- 296
Query: 885 QTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLLIACHRGHMQL 944
FH + GN +++ I+ D S +N N G TPL++A G + L
Sbjct: 297 ---------FHALKM-GN----FQLVKEIADEDPSH-VNLVNGDGATPLMLAAVTGQLAL 341
Query: 945 VNTLLTNHARVDVFD-VEGRSALHLAAEHGYLQVCDALLTNKAFINSKARNGRTALHLAA 1003
V L+ HA VD D V G +AL A HG ++ LL A + +A+NG TA L
Sbjct: 342 VQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVM 401
Query: 1004 M 1004
+
Sbjct: 402 L 402
Score = 66.5 bits (155), Expect = 1e-09
Identities = 94/360 (26%), Positives = 155/360 (43%), Gaps = 41/360 (11%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G T L A GH LV LL A V+ + G SAL AA G++ V LL + A +
Sbjct: 78 GNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADV 137
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N++ R G + L +A+ G+ +VK L+ + A +D H + Q
Sbjct: 138 NAQNRLGASVLTVASRGGHLGVVKLLL-EAGAFVD----------HHHPSGEQ------- 179
Query: 1049 LELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGS 1108
L LG + D + L + AA Q+ + VV+L ++ + A G + +AA+ G
Sbjct: 180 LGLGGSRD--EPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGR 237
Query: 1109 VKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVL--VRAGASCTDENRAGL 1166
+ V ++L++ G + + T ++A + H D+V L + TDE +
Sbjct: 238 LGVAQQLVE---KGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRP 294
Query: 1167 TAVHLAAEHGHTNVLDVMRSTNTLRIS-SKKLGLTPLHIAAYYGQAETVRELLSHVPGTV 1225
H A + G+ ++ + + ++ G TPL +AA GQ V+ L+
Sbjct: 295 DIFH-ALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVD 353
Query: 1226 KSEAPTGVSLVPVLGAESGLTPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHL 1285
K + + G T L A Y+GN+ +V+ LLN G + +NGY L
Sbjct: 354 KQD------------SVHGWTALMQATYHGNKEIVKYLLNQ-GADVTLRA-KNGYTAFDL 399
Score = 63.3 bits (147), Expect = 9e-09
Identities = 48/164 (29%), Positives = 72/164 (43%), Gaps = 8/164 (4%)
Query: 1242 ESGLTP-----LHLAAYNGNENVVRLLLNSAGVQAD-AASNENGYNPLHLACFGGHMSIV 1295
E GL P L E RLL A A+ A E G P G +
Sbjct: 3 EGGLPPAFQLLLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAA 62
Query: 1296 GLLLSRSAELLHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAK 1355
G + + + +D G T L A+ GH +V LL +GA +N+ + GW+ L AA+
Sbjct: 63 GAV--GAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAAR 120
Query: 1356 AGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHNDVLEYLL 1399
GH++V LL + GA ++ L + + A+ H V++ LL
Sbjct: 121 FGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLL 164
Score = 56.4 bits (130), Expect = 1e-06
Identities = 74/310 (23%), Positives = 126/310 (40%), Gaps = 24/310 (7%)
Query: 750 LLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRKTKVCIYDVVTGETPLQ 809
LL+ GA N G + + AA+FG+++ LLL+ G D + ++ G + L
Sbjct: 97 LLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNRL-------GASVLT 149
Query: 810 MACRSCMPDIVRHLIE---FVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPT 866
+A R +V+ L+E FV H + DE +T I
Sbjct: 150 VASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDE--------PLDITALMAAIQH 201
Query: 867 ADRQVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQN 926
VV+ L+E GAD + R + A+ G V +++ + D L +
Sbjct: 202 GHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEK-- 259
Query: 927 SIGWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALL-TNK 985
+ L HR + ++ L T + D + + R + A + G Q+ + +
Sbjct: 260 -TAFEVALDCKHRDLVDYLDPLTTVRPKTD--EEKRRPDIFHALKMGNFQLVKEIADEDP 316
Query: 986 AFINSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVC 1045
+ +N +G T L LAA+ G LV+ L+ H + ++ T L A G E+
Sbjct: 317 SHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIV 376
Query: 1046 KLLLELGANI 1055
K LL GA++
Sbjct: 377 KYLLNQGADV 386
Score = 56.4 bits (130), Expect = 1e-06
Identities = 88/306 (28%), Positives = 128/306 (41%), Gaps = 47/306 (15%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGA-- 720
G ++ AAR+GHV + + LL G V+ + L +A VV+ LL GA
Sbjct: 111 GWSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFV 170
Query: 721 DVHIRGGKQ------RETPLHIA---ARIPDGDKCAL-MLLKSGAGPNKATED-GMTPVH 769
D H G+Q R+ PL I A I G + + +L++ GA PN A G +P+
Sbjct: 171 DHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLM 230
Query: 770 VAAKFGNLATLVLLLEDGGDP-----LRKTKV-----CIY-DVVTGETPLQMAC-----R 813
+AA G L L+E G +P L KT C + D+V PL
Sbjct: 231 LAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEE 290
Query: 814 SCMPDIVRHL----IEFVKDHKGESVSTAFIDAVDEDGASALHYACKVTKEEVKIPTADR 869
PDI L + VK+ E S ++ V+ DGA+ L A T
Sbjct: 291 KRRPDIFHALKMGNFQLVKEIADEDPS--HVNLVNGDGATPLMLAA---------VTGQL 339
Query: 870 QVVKCLIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVS-RALNRQNSI 928
+V+ L+E ADV Q + TA GN +++ ++ ADV+ RA N +
Sbjct: 340 ALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLN--QGADVTLRAKNGYTAF 397
Query: 929 GWTPLL 934
LL
Sbjct: 398 DLVMLL 403
Score = 54.0 bits (124), Expect = 5e-06
Identities = 45/165 (27%), Positives = 72/165 (43%), Gaps = 4/165 (2%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARI-LVDYGAVVD 125
LL A + G+ R LL AE + A A A V VD
Sbjct: 13 LLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVPVD 72
Query: 126 ATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTPMHLAAENGHAAIIELLAD 185
++ AG T L AAA G EPLV++ A+ ++ + + AA GH ++ LL D
Sbjct: 73 CSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLD 132
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVYL--HMPN 228
A + + + G++++ +AS GH +L + G ++ H P+
Sbjct: 133 -HGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPS 176
Score = 44.8 bits (101), Expect = 0.003
Identities = 39/155 (25%), Positives = 74/155 (47%), Gaps = 2/155 (1%)
Query: 67 LLLAVEAGNQSMVRELLSAQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYGAVVDA 126
L+ A++ G++++VR LL A+ A G + L LAA + +A+ LV+ GA D
Sbjct: 195 LMAAIQHGHEAVVR-LLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDH 253
Query: 127 TNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNEDRTP-MHLAAENGHAAIIELLAD 185
+ +T +A LV Y + D E R P + A + G+ +++ +AD
Sbjct: 254 LSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIAD 313
Query: 186 KFKASIFERTKDGSTLMHIASLNGHADCAMMLFKK 220
+ + + DG+T + +A++ G +L ++
Sbjct: 314 EDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVER 348
Score = 36.3 bits (80), Expect = 1.2
Identities = 27/110 (24%), Positives = 48/110 (43%), Gaps = 3/110 (2%)
Query: 1333 LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLCESGASPKSETNLNCAPIWFAASENHN 1392
+G ++ +D+ G T L AA GH +V+ L GAS S + + + AA H
Sbjct: 65 VGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHV 124
Query: 1393 DVLEYLLHKEHDTQSLMDDKRFVYNLMVCSKNHNNIPIEEFVLVSPAPVD 1442
V LL D + R +++ + ++ + + +L + A VD
Sbjct: 125 SVAHLLLDHGADVNA---QNRLGASVLTVASRGGHLGVVKLLLEAGAFVD 171
Score = 35.9 bits (79), Expect = 1.6
Identities = 28/93 (30%), Positives = 43/93 (46%), Gaps = 2/93 (2%)
Query: 662 DGARSIHTAARYGHVGIINTLLQKGESVDVTTN-DNYTALHIAVESCKPAVVETLLGYGA 720
DGA + AA G + ++ L+++ VD + +TAL A +V+ LL GA
Sbjct: 325 DGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGA 384
Query: 721 DVHIRGGKQRETPLHIAARIPDGDKCALMLLKS 753
DV +R K T + + D D + LL S
Sbjct: 385 DVTLR-AKNGYTAFDLVMLLNDPDTELVRLLAS 416
Score = 33.5 bits (73), Expect = 8.3
Identities = 59/277 (21%), Positives = 108/277 (38%), Gaps = 24/277 (8%)
Query: 63 GKVPLLLAVEAGNQSMVRELLS-AQTAEQLKATTPAGDTALHLAARRRDVDMARILVDYG 121
G PL+LA G + ++L+ + L TA +A + D+ L
Sbjct: 225 GWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEK---TAFEVALDCKHRDLVDYLDPLT 281
Query: 122 AVVDATNGAGQTP-LHIAAAEGDEPLVKYFYGVR-ANAAIADNEDRTPMHLAAENGHAAI 179
V T+ + P + A G+ LVK ++ + + + TP+ LAA G A+
Sbjct: 282 TVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLAL 341
Query: 180 IELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKG--VYLHMPNKYFEKQTFD 237
++LL ++ + + G T + A+ +G+ + L +G V L N Y FD
Sbjct: 342 VQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGY---TAFD 398
Query: 238 EVLFVKIENGLIKGLKSDDGSYSMFLGIPYALVNESNPFGDSLPTLPFNEIYEAFDDSTA 297
V+ L D L VN+ P LP +++ + +
Sbjct: 399 LVML----------LNDPDTELVRLLASVCMQVNKDKGRPSHQPPLPHSKVRQPWSIPVL 448
Query: 298 CPQK---EEFNNTIVGEMQCLRLNIYVPKSLNNNLPV 331
K + + N + + L+L +P+ L++N P+
Sbjct: 449 PDDKGGLKSWWNRMSNRFRKLKLMQTLPRGLSSNQPL 485
>DQ388145-2|ABD72216.1| 1482|Homo sapiens CTTNBP2 protein.
Length = 1482
Score = 91.5 bits (217), Expect = 3e-17
Identities = 54/155 (34%), Positives = 85/155 (54%), Gaps = 2/155 (1%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
T L AA GN ++ +LLN G+ + S E+G++ L+ A GH V LLLS A++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINY-SCEDGHSALYSAAKNGHTDCVRLLLSAEAQV 770
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D++G T L A+ GH++ VE+L+ A IN G TPL+ A K G+ +KLL
Sbjct: 771 -NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
E+G + +T P+ A + D L+ L++
Sbjct: 830 LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY 864
Score = 87.8 bits (208), Expect = 4e-16
Identities = 68/223 (30%), Positives = 103/223 (46%), Gaps = 8/223 (3%)
Query: 966 LHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
L AA G + + LL + IN +G +AL+ AA NG+ V+ L+ A ++
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQVNA 772
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TPL AAA G E +LL+ ANI+ + GQ P++ A +N E ++L L+
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
N + TT DG T H A G+V ++ LM + R +S +GG
Sbjct: 833 GTNRSVKTT-DGWTPVHAAVDTGNVDSLKLLM-YHRIPAHGNSFNEEESESSVFDLDGGE 890
Query: 1145 AD---VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ + +V A NR G TA H+AA G N L+++
Sbjct: 891 ESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEIL 932
Score = 77.8 bits (183), Expect = 4e-13
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 21/270 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T LQ AA G+ ++ +L+ G G +A++ AA++GHT+ + ++ S
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPL AA G E V L+S+ + A+ G TPL+LA
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-------------ADGGQTPLYLAC 818
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
NGN+ ++LLL AG + + G+ P+H A G++ + LL+ ++
Sbjct: 819 KNGNKECIKLLLE-AGTNRSVKTTD-GWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE 876
Query: 1313 GKTGLHIASTHGHYQMVEVL---LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC-ES 1368
++ + G + E + + IN ++ GWT H AA G N +++LC
Sbjct: 877 EESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G P+ N + A+++ +LE L
Sbjct: 937 GLEPERRDKCN-RTVHDVATDDCKHLLENL 965
Score = 70.1 bits (164), Expect = 8e-11
Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 6/129 (4%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y DG ++++AA+ GH + LL V+ + +T L A VE L+
Sbjct: 739 YSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS 798
Query: 718 YGADV-HIRGGKQRETPLHIAARIPDGDK-CALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y A++ H G Q TPL++A + +G+K C +LL++G + T DG TPVH A G
Sbjct: 799 YDANINHAADGGQ--TPLYLACK--NGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
Query: 776 NLATLVLLL 784
N+ +L LL+
Sbjct: 855 NVDSLKLLM 863
Score = 68.5 bits (160), Expect = 2e-10
Identities = 57/196 (29%), Positives = 94/196 (47%), Gaps = 10/196 (5%)
Query: 51 WKKLIRDLVFQRGKVPL-----LL--AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH 103
W + L+ G PL LL A GN +++ LL+ + + + + G +AL+
Sbjct: 691 WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLD-INYSCEDGHSALY 749
Query: 104 LAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE 163
AA+ D R+L+ A V+A + G TPL AAA+G V+ AN A +
Sbjct: 750 SAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG 809
Query: 164 DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
+TP++LA +NG+ I+LL + + +T DG T +H A G+ D +L +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEA-GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
Query: 224 LHMPNKYFEKQTFDEV 239
H N + E+++ V
Sbjct: 869 AH-GNSFNEEESESSV 883
Score = 68.5 bits (160), Expect = 2e-10
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 4/192 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G + L A GH V LL+ A+V+ D G + L AA G+ + + L++ A I
Sbjct: 744 GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI 803
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N A G+T L+LA NG +K L+ + V T TP+H A +G ++ KLL
Sbjct: 804 NHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Query: 1049 L--ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP-NLVMATTKDGNTCAHIAAI 1105
+ + A+ ++ +E + + P +L+ ++G T AHIAA
Sbjct: 863 MYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS 922
Query: 1106 QGSVKVIEELMK 1117
+G +E L +
Sbjct: 923 KGFKNCLEILCR 934
Score = 61.3 bits (142), Expect = 4e-08
Identities = 58/230 (25%), Positives = 105/230 (45%), Gaps = 30/230 (13%)
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
AAAQ N + ++ + L + + + +DG++ + AA G + L+ + ++A
Sbjct: 717 AAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--VNAA 773
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
+K N TPL AA GH + V +L+ A+ G T ++LA ++G+ + ++
Sbjct: 774 DK-NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTVKS-----------------EA 1229
T R G TP+H A G ++++ L+ H +P S E+
Sbjct: 833 GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEES 892
Query: 1230 PTGVSLVPVLGAE-------SGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
P G+S PV+ A+ G T H+AA G +N + +L G++ +
Sbjct: 893 PEGIS-KPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
Score = 56.8 bits (131), Expect = 8e-07
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 4/156 (2%)
Query: 997 TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID 1056
T L AA G L+ L+ + I+ + L+ AA +G + +LLL A ++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1057 ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
A D+ G P+ AAA + E V+L + N+ A G T ++A G+ + I+ L+
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-ADGGQTPLYLACKNGNKECIKLLL 830
Query: 1117 KFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+ G + + TP+ A + G+ D +++L+
Sbjct: 831 E---AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 56.0 bits (129), Expect = 1e-06
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 667 IHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+ AA G+V +++ LL ++G ++ + D ++AL+ A ++ V LL A V+
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA- 772
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
K TPL AA +C +L+ A N A + G TP+++A K GN + LLLE
Sbjct: 773 ADKNGFTPL-CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 786 DGGDPLRKT 794
G + KT
Sbjct: 832 AGTNRSVKT 840
Score = 47.2 bits (107), Expect = 6e-04
Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L E G D++ H +A + A G+ D + +++ +N + G+TPL
Sbjct: 730 LNEEGLDINYSCEDGH-SALYSAAKNGHTDCVRLLLS------AEAQVNAADKNGFTPLC 782
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
A +GH + V L++ A ++ G++ L+LA ++G + LL + K +
Sbjct: 783 AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD 842
Query: 995 GRTALHLAAMNGYAHLVKFLI 1015
G T +H A G +K L+
Sbjct: 843 GWTPVHAAVDTGNVDSLKLLM 863
Score = 44.4 bits (100), Expect = 0.004
Identities = 37/149 (24%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A + G+ I LL+ G + V T D +T +H AV++ ++ L+ +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA 869
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP---NKATEDGMTPVHVAAKFGNLAT 779
H + E+ + + G++ + K N A +G T H+AA G
Sbjct: 870 HGNSFNEEESESSV-FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNC 928
Query: 780 LVLLLEDGG-DPLRKTKV--CIYDVVTGE 805
L +L GG +P R+ K ++DV T +
Sbjct: 929 LEILCRHGGLEPERRDKCNRTVHDVATDD 957
Score = 35.1 bits (77), Expect = 2.7
Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 13/125 (10%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L+ AA+ D C +LL + A N A ++G TP+ AA G+ + LL+ +
Sbjct: 748 LYSAAKNGHTD-CVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN---- 802
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIE-----FVKDHKGESVSTAFIDAVDEDGA 848
+ G+TPL +AC++ + ++ L+E VK G + A +D + D
Sbjct: 803 ---INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL 859
Query: 849 SALHY 853
L Y
Sbjct: 860 KLLMY 864
>DQ388144-2|ABD72214.1| 1663|Homo sapiens CTTNBP2 protein.
Length = 1663
Score = 91.5 bits (217), Expect = 3e-17
Identities = 54/155 (34%), Positives = 85/155 (54%), Gaps = 2/155 (1%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
T L AA GN ++ +LLN G+ + S E+G++ L+ A GH V LLLS A++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINY-SCEDGHSALYSAAKNGHTDCVRLLLSAEAQV 770
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D++G T L A+ GH++ VE+L+ A IN G TPL+ A K G+ +KLL
Sbjct: 771 -NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
E+G + +T P+ A + D L+ L++
Sbjct: 830 LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY 864
Score = 87.8 bits (208), Expect = 4e-16
Identities = 68/223 (30%), Positives = 103/223 (46%), Gaps = 8/223 (3%)
Query: 966 LHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
L AA G + + LL + IN +G +AL+ AA NG+ V+ L+ A ++
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQVNA 772
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TPL AAA G E +LL+ ANI+ + GQ P++ A +N E ++L L+
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
N + TT DG T H A G+V ++ LM + R +S +GG
Sbjct: 833 GTNRSVKTT-DGWTPVHAAVDTGNVDSLKLLM-YHRIPAHGNSFNEEESESSVFDLDGGE 890
Query: 1145 AD---VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ + +V A NR G TA H+AA G N L+++
Sbjct: 891 ESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEIL 932
Score = 77.8 bits (183), Expect = 4e-13
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 21/270 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T LQ AA G+ ++ +L+ G G +A++ AA++GHT+ + ++ S
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPL AA G E V L+S+ + A+ G TPL+LA
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-------------ADGGQTPLYLAC 818
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
NGN+ ++LLL AG + + G+ P+H A G++ + LL+ ++
Sbjct: 819 KNGNKECIKLLLE-AGTNRSVKTTD-GWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE 876
Query: 1313 GKTGLHIASTHGHYQMVEVL---LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC-ES 1368
++ + G + E + + IN ++ GWT H AA G N +++LC
Sbjct: 877 EESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G P+ N + A+++ +LE L
Sbjct: 937 GLEPERRDKCN-RTVHDVATDDCKHLLENL 965
Score = 70.1 bits (164), Expect = 8e-11
Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 6/129 (4%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y DG ++++AA+ GH + LL V+ + +T L A VE L+
Sbjct: 739 YSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS 798
Query: 718 YGADV-HIRGGKQRETPLHIAARIPDGDK-CALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y A++ H G Q TPL++A + +G+K C +LL++G + T DG TPVH A G
Sbjct: 799 YDANINHAADGGQ--TPLYLACK--NGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
Query: 776 NLATLVLLL 784
N+ +L LL+
Sbjct: 855 NVDSLKLLM 863
Score = 68.5 bits (160), Expect = 2e-10
Identities = 57/196 (29%), Positives = 94/196 (47%), Gaps = 10/196 (5%)
Query: 51 WKKLIRDLVFQRGKVPL-----LL--AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH 103
W + L+ G PL LL A GN +++ LL+ + + + + G +AL+
Sbjct: 691 WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLD-INYSCEDGHSALY 749
Query: 104 LAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE 163
AA+ D R+L+ A V+A + G TPL AAA+G V+ AN A +
Sbjct: 750 SAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG 809
Query: 164 DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
+TP++LA +NG+ I+LL + + +T DG T +H A G+ D +L +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEA-GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
Query: 224 LHMPNKYFEKQTFDEV 239
H N + E+++ V
Sbjct: 869 AH-GNSFNEEESESSV 883
Score = 68.5 bits (160), Expect = 2e-10
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 4/192 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G + L A GH V LL+ A+V+ D G + L AA G+ + + L++ A I
Sbjct: 744 GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI 803
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N A G+T L+LA NG +K L+ + V T TP+H A +G ++ KLL
Sbjct: 804 NHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Query: 1049 L--ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP-NLVMATTKDGNTCAHIAAI 1105
+ + A+ ++ +E + + P +L+ ++G T AHIAA
Sbjct: 863 MYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS 922
Query: 1106 QGSVKVIEELMK 1117
+G +E L +
Sbjct: 923 KGFKNCLEILCR 934
Score = 61.3 bits (142), Expect = 4e-08
Identities = 58/230 (25%), Positives = 105/230 (45%), Gaps = 30/230 (13%)
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
AAAQ N + ++ + L + + + +DG++ + AA G + L+ + ++A
Sbjct: 717 AAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--VNAA 773
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
+K N TPL AA GH + V +L+ A+ G T ++LA ++G+ + ++
Sbjct: 774 DK-NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTVKS-----------------EA 1229
T R G TP+H A G ++++ L+ H +P S E+
Sbjct: 833 GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEES 892
Query: 1230 PTGVSLVPVLGAE-------SGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
P G+S PV+ A+ G T H+AA G +N + +L G++ +
Sbjct: 893 PEGIS-KPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
Score = 56.8 bits (131), Expect = 8e-07
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 4/156 (2%)
Query: 997 TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID 1056
T L AA G L+ L+ + I+ + L+ AA +G + +LLL A ++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1057 ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
A D+ G P+ AAA + E V+L + N+ A G T ++A G+ + I+ L+
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-ADGGQTPLYLACKNGNKECIKLLL 830
Query: 1117 KFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+ G + + TP+ A + G+ D +++L+
Sbjct: 831 E---AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 56.0 bits (129), Expect = 1e-06
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 667 IHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+ AA G+V +++ LL ++G ++ + D ++AL+ A ++ V LL A V+
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA- 772
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
K TPL AA +C +L+ A N A + G TP+++A K GN + LLLE
Sbjct: 773 ADKNGFTPL-CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 786 DGGDPLRKT 794
G + KT
Sbjct: 832 AGTNRSVKT 840
Score = 47.2 bits (107), Expect = 6e-04
Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L E G D++ H +A + A G+ D + +++ +N + G+TPL
Sbjct: 730 LNEEGLDINYSCEDGH-SALYSAAKNGHTDCVRLLLS------AEAQVNAADKNGFTPLC 782
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
A +GH + V L++ A ++ G++ L+LA ++G + LL + K +
Sbjct: 783 AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD 842
Query: 995 GRTALHLAAMNGYAHLVKFLI 1015
G T +H A G +K L+
Sbjct: 843 GWTPVHAAVDTGNVDSLKLLM 863
Score = 44.4 bits (100), Expect = 0.004
Identities = 37/149 (24%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A + G+ I LL+ G + V T D +T +H AV++ ++ L+ +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA 869
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP---NKATEDGMTPVHVAAKFGNLAT 779
H + E+ + + G++ + K N A +G T H+AA G
Sbjct: 870 HGNSFNEEESESSV-FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNC 928
Query: 780 LVLLLEDGG-DPLRKTKV--CIYDVVTGE 805
L +L GG +P R+ K ++DV T +
Sbjct: 929 LEILCRHGGLEPERRDKCNRTVHDVATDD 957
Score = 35.1 bits (77), Expect = 2.7
Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 13/125 (10%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L+ AA+ D C +LL + A N A ++G TP+ AA G+ + LL+ +
Sbjct: 748 LYSAAKNGHTD-CVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN---- 802
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIE-----FVKDHKGESVSTAFIDAVDEDGA 848
+ G+TPL +AC++ + ++ L+E VK G + A +D + D
Sbjct: 803 ---INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL 859
Query: 849 SALHY 853
L Y
Sbjct: 860 KLLMY 864
>DQ388143-2|ABD72212.1| 1663|Homo sapiens CTTNBP2 protein.
Length = 1663
Score = 91.5 bits (217), Expect = 3e-17
Identities = 54/155 (34%), Positives = 85/155 (54%), Gaps = 2/155 (1%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
T L AA GN ++ +LLN G+ + S E+G++ L+ A GH V LLLS A++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINY-SCEDGHSALYSAAKNGHTDCVRLLLSAEAQV 770
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D++G T L A+ GH++ VE+L+ A IN G TPL+ A K G+ +KLL
Sbjct: 771 -NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
E+G + +T P+ A + D L+ L++
Sbjct: 830 LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY 864
Score = 87.8 bits (208), Expect = 4e-16
Identities = 68/223 (30%), Positives = 103/223 (46%), Gaps = 8/223 (3%)
Query: 966 LHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
L AA G + + LL + IN +G +AL+ AA NG+ V+ L+ A ++
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQVNA 772
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TPL AAA G E +LL+ ANI+ + GQ P++ A +N E ++L L+
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
N + TT DG T H A G+V ++ LM + R +S +GG
Sbjct: 833 GTNRSVKTT-DGWTPVHAAVDTGNVDSLKLLM-YHRIPAHGNSFNEEESESSVFDLDGGE 890
Query: 1145 AD---VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ + +V A NR G TA H+AA G N L+++
Sbjct: 891 ESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEIL 932
Score = 77.8 bits (183), Expect = 4e-13
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 21/270 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T LQ AA G+ ++ +L+ G G +A++ AA++GHT+ + ++ S
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPL AA G E V L+S+ + A+ G TPL+LA
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-------------ADGGQTPLYLAC 818
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
NGN+ ++LLL AG + + G+ P+H A G++ + LL+ ++
Sbjct: 819 KNGNKECIKLLLE-AGTNRSVKTTD-GWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE 876
Query: 1313 GKTGLHIASTHGHYQMVEVL---LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC-ES 1368
++ + G + E + + IN ++ GWT H AA G N +++LC
Sbjct: 877 EESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G P+ N + A+++ +LE L
Sbjct: 937 GLEPERRDKCN-RTVHDVATDDCKHLLENL 965
Score = 70.1 bits (164), Expect = 8e-11
Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 6/129 (4%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y DG ++++AA+ GH + LL V+ + +T L A VE L+
Sbjct: 739 YSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS 798
Query: 718 YGADV-HIRGGKQRETPLHIAARIPDGDK-CALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y A++ H G Q TPL++A + +G+K C +LL++G + T DG TPVH A G
Sbjct: 799 YDANINHAADGGQ--TPLYLACK--NGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
Query: 776 NLATLVLLL 784
N+ +L LL+
Sbjct: 855 NVDSLKLLM 863
Score = 68.5 bits (160), Expect = 2e-10
Identities = 57/196 (29%), Positives = 94/196 (47%), Gaps = 10/196 (5%)
Query: 51 WKKLIRDLVFQRGKVPL-----LL--AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH 103
W + L+ G PL LL A GN +++ LL+ + + + + G +AL+
Sbjct: 691 WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLD-INYSCEDGHSALY 749
Query: 104 LAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE 163
AA+ D R+L+ A V+A + G TPL AAA+G V+ AN A +
Sbjct: 750 SAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG 809
Query: 164 DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
+TP++LA +NG+ I+LL + + +T DG T +H A G+ D +L +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEA-GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
Query: 224 LHMPNKYFEKQTFDEV 239
H N + E+++ V
Sbjct: 869 AH-GNSFNEEESESSV 883
Score = 68.5 bits (160), Expect = 2e-10
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 4/192 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G + L A GH V LL+ A+V+ D G + L AA G+ + + L++ A I
Sbjct: 744 GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI 803
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N A G+T L+LA NG +K L+ + V T TP+H A +G ++ KLL
Sbjct: 804 NHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Query: 1049 L--ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP-NLVMATTKDGNTCAHIAAI 1105
+ + A+ ++ +E + + P +L+ ++G T AHIAA
Sbjct: 863 MYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS 922
Query: 1106 QGSVKVIEELMK 1117
+G +E L +
Sbjct: 923 KGFKNCLEILCR 934
Score = 61.3 bits (142), Expect = 4e-08
Identities = 58/230 (25%), Positives = 105/230 (45%), Gaps = 30/230 (13%)
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
AAAQ N + ++ + L + + + +DG++ + AA G + L+ + ++A
Sbjct: 717 AAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--VNAA 773
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
+K N TPL AA GH + V +L+ A+ G T ++LA ++G+ + ++
Sbjct: 774 DK-NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTVKS-----------------EA 1229
T R G TP+H A G ++++ L+ H +P S E+
Sbjct: 833 GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEES 892
Query: 1230 PTGVSLVPVLGAE-------SGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
P G+S PV+ A+ G T H+AA G +N + +L G++ +
Sbjct: 893 PEGIS-KPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
Score = 56.8 bits (131), Expect = 8e-07
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 4/156 (2%)
Query: 997 TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID 1056
T L AA G L+ L+ + I+ + L+ AA +G + +LLL A ++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1057 ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
A D+ G P+ AAA + E V+L + N+ A G T ++A G+ + I+ L+
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-ADGGQTPLYLACKNGNKECIKLLL 830
Query: 1117 KFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+ G + + TP+ A + G+ D +++L+
Sbjct: 831 E---AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 56.0 bits (129), Expect = 1e-06
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 667 IHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+ AA G+V +++ LL ++G ++ + D ++AL+ A ++ V LL A V+
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA- 772
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
K TPL AA +C +L+ A N A + G TP+++A K GN + LLLE
Sbjct: 773 ADKNGFTPL-CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 786 DGGDPLRKT 794
G + KT
Sbjct: 832 AGTNRSVKT 840
Score = 47.2 bits (107), Expect = 6e-04
Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L E G D++ H +A + A G+ D + +++ +N + G+TPL
Sbjct: 730 LNEEGLDINYSCEDGH-SALYSAAKNGHTDCVRLLLS------AEAQVNAADKNGFTPLC 782
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
A +GH + V L++ A ++ G++ L+LA ++G + LL + K +
Sbjct: 783 AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD 842
Query: 995 GRTALHLAAMNGYAHLVKFLI 1015
G T +H A G +K L+
Sbjct: 843 GWTPVHAAVDTGNVDSLKLLM 863
Score = 44.4 bits (100), Expect = 0.004
Identities = 37/149 (24%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A + G+ I LL+ G + V T D +T +H AV++ ++ L+ +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA 869
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP---NKATEDGMTPVHVAAKFGNLAT 779
H + E+ + + G++ + K N A +G T H+AA G
Sbjct: 870 HGNSFNEEESESSV-FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNC 928
Query: 780 LVLLLEDGG-DPLRKTKV--CIYDVVTGE 805
L +L GG +P R+ K ++DV T +
Sbjct: 929 LEILCRHGGLEPERRDKCNRTVHDVATDD 957
Score = 35.1 bits (77), Expect = 2.7
Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 13/125 (10%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L+ AA+ D C +LL + A N A ++G TP+ AA G+ + LL+ +
Sbjct: 748 LYSAAKNGHTD-CVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN---- 802
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIE-----FVKDHKGESVSTAFIDAVDEDGA 848
+ G+TPL +AC++ + ++ L+E VK G + A +D + D
Sbjct: 803 ---INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL 859
Query: 849 SALHY 853
L Y
Sbjct: 860 KLLMY 864
>DQ388142-2|ABD72210.1| 1663|Homo sapiens CTTNBP2 protein.
Length = 1663
Score = 91.5 bits (217), Expect = 3e-17
Identities = 54/155 (34%), Positives = 85/155 (54%), Gaps = 2/155 (1%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
T L AA GN ++ +LLN G+ + S E+G++ L+ A GH V LLLS A++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINY-SCEDGHSALYSAAKNGHTDCVRLLLSAEAQV 770
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D++G T L A+ GH++ VE+L+ A IN G TPL+ A K G+ +KLL
Sbjct: 771 -NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
E+G + +T P+ A + D L+ L++
Sbjct: 830 LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY 864
Score = 87.8 bits (208), Expect = 4e-16
Identities = 68/223 (30%), Positives = 103/223 (46%), Gaps = 8/223 (3%)
Query: 966 LHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
L AA G + + LL + IN +G +AL+ AA NG+ V+ L+ A ++
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQVNA 772
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TPL AAA G E +LL+ ANI+ + GQ P++ A +N E ++L L+
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
N + TT DG T H A G+V ++ LM + R +S +GG
Sbjct: 833 GTNRSVKTT-DGWTPVHAAVDTGNVDSLKLLM-YHRIPAHGNSFNEEESESSVFDLDGGE 890
Query: 1145 AD---VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ + +V A NR G TA H+AA G N L+++
Sbjct: 891 ESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEIL 932
Score = 77.8 bits (183), Expect = 4e-13
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 21/270 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T LQ AA G+ ++ +L+ G G +A++ AA++GHT+ + ++ S
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPL AA G E V L+S+ + A+ G TPL+LA
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-------------ADGGQTPLYLAC 818
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
NGN+ ++LLL AG + + G+ P+H A G++ + LL+ ++
Sbjct: 819 KNGNKECIKLLLE-AGTNRSVKTTD-GWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE 876
Query: 1313 GKTGLHIASTHGHYQMVEVL---LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC-ES 1368
++ + G + E + + IN ++ GWT H AA G N +++LC
Sbjct: 877 EESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G P+ N + A+++ +LE L
Sbjct: 937 GLEPERRDKCN-RTVHDVATDDCKHLLENL 965
Score = 70.1 bits (164), Expect = 8e-11
Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 6/129 (4%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y DG ++++AA+ GH + LL V+ + +T L A VE L+
Sbjct: 739 YSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS 798
Query: 718 YGADV-HIRGGKQRETPLHIAARIPDGDK-CALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y A++ H G Q TPL++A + +G+K C +LL++G + T DG TPVH A G
Sbjct: 799 YDANINHAADGGQ--TPLYLACK--NGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
Query: 776 NLATLVLLL 784
N+ +L LL+
Sbjct: 855 NVDSLKLLM 863
Score = 68.5 bits (160), Expect = 2e-10
Identities = 57/196 (29%), Positives = 94/196 (47%), Gaps = 10/196 (5%)
Query: 51 WKKLIRDLVFQRGKVPL-----LL--AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH 103
W + L+ G PL LL A GN +++ LL+ + + + + G +AL+
Sbjct: 691 WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLD-INYSCEDGHSALY 749
Query: 104 LAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE 163
AA+ D R+L+ A V+A + G TPL AAA+G V+ AN A +
Sbjct: 750 SAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG 809
Query: 164 DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
+TP++LA +NG+ I+LL + + +T DG T +H A G+ D +L +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEA-GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
Query: 224 LHMPNKYFEKQTFDEV 239
H N + E+++ V
Sbjct: 869 AH-GNSFNEEESESSV 883
Score = 68.5 bits (160), Expect = 2e-10
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 4/192 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G + L A GH V LL+ A+V+ D G + L AA G+ + + L++ A I
Sbjct: 744 GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI 803
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N A G+T L+LA NG +K L+ + V T TP+H A +G ++ KLL
Sbjct: 804 NHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Query: 1049 L--ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP-NLVMATTKDGNTCAHIAAI 1105
+ + A+ ++ +E + + P +L+ ++G T AHIAA
Sbjct: 863 MYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS 922
Query: 1106 QGSVKVIEELMK 1117
+G +E L +
Sbjct: 923 KGFKNCLEILCR 934
Score = 61.3 bits (142), Expect = 4e-08
Identities = 58/230 (25%), Positives = 105/230 (45%), Gaps = 30/230 (13%)
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
AAAQ N + ++ + L + + + +DG++ + AA G + L+ + ++A
Sbjct: 717 AAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--VNAA 773
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
+K N TPL AA GH + V +L+ A+ G T ++LA ++G+ + ++
Sbjct: 774 DK-NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTVKS-----------------EA 1229
T R G TP+H A G ++++ L+ H +P S E+
Sbjct: 833 GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEES 892
Query: 1230 PTGVSLVPVLGAE-------SGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
P G+S PV+ A+ G T H+AA G +N + +L G++ +
Sbjct: 893 PEGIS-KPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
Score = 56.8 bits (131), Expect = 8e-07
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 4/156 (2%)
Query: 997 TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID 1056
T L AA G L+ L+ + I+ + L+ AA +G + +LLL A ++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1057 ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
A D+ G P+ AAA + E V+L + N+ A G T ++A G+ + I+ L+
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-ADGGQTPLYLACKNGNKECIKLLL 830
Query: 1117 KFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+ G + + TP+ A + G+ D +++L+
Sbjct: 831 E---AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 56.0 bits (129), Expect = 1e-06
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 667 IHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+ AA G+V +++ LL ++G ++ + D ++AL+ A ++ V LL A V+
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA- 772
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
K TPL AA +C +L+ A N A + G TP+++A K GN + LLLE
Sbjct: 773 ADKNGFTPL-CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 786 DGGDPLRKT 794
G + KT
Sbjct: 832 AGTNRSVKT 840
Score = 47.2 bits (107), Expect = 6e-04
Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L E G D++ H +A + A G+ D + +++ +N + G+TPL
Sbjct: 730 LNEEGLDINYSCEDGH-SALYSAAKNGHTDCVRLLLS------AEAQVNAADKNGFTPLC 782
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
A +GH + V L++ A ++ G++ L+LA ++G + LL + K +
Sbjct: 783 AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD 842
Query: 995 GRTALHLAAMNGYAHLVKFLI 1015
G T +H A G +K L+
Sbjct: 843 GWTPVHAAVDTGNVDSLKLLM 863
Score = 44.4 bits (100), Expect = 0.004
Identities = 37/149 (24%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A + G+ I LL+ G + V T D +T +H AV++ ++ L+ +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA 869
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP---NKATEDGMTPVHVAAKFGNLAT 779
H + E+ + + G++ + K N A +G T H+AA G
Sbjct: 870 HGNSFNEEESESSV-FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNC 928
Query: 780 LVLLLEDGG-DPLRKTKV--CIYDVVTGE 805
L +L GG +P R+ K ++DV T +
Sbjct: 929 LEILCRHGGLEPERRDKCNRTVHDVATDD 957
Score = 35.1 bits (77), Expect = 2.7
Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 13/125 (10%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L+ AA+ D C +LL + A N A ++G TP+ AA G+ + LL+ +
Sbjct: 748 LYSAAKNGHTD-CVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN---- 802
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIE-----FVKDHKGESVSTAFIDAVDEDGA 848
+ G+TPL +AC++ + ++ L+E VK G + A +D + D
Sbjct: 803 ---INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL 859
Query: 849 SALHY 853
L Y
Sbjct: 860 KLLMY 864
>DQ388141-2|ABD72208.1| 1663|Homo sapiens CTTNBP2 protein.
Length = 1663
Score = 91.5 bits (217), Expect = 3e-17
Identities = 54/155 (34%), Positives = 85/155 (54%), Gaps = 2/155 (1%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
T L AA GN ++ +LLN G+ + S E+G++ L+ A GH V LLLS A++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINY-SCEDGHSALYSAAKNGHTDCVRLLLSAEAQV 770
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D++G T L A+ GH++ VE+L+ A IN G TPL+ A K G+ +KLL
Sbjct: 771 -NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
E+G + +T P+ A + D L+ L++
Sbjct: 830 LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY 864
Score = 87.8 bits (208), Expect = 4e-16
Identities = 68/223 (30%), Positives = 103/223 (46%), Gaps = 8/223 (3%)
Query: 966 LHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
L AA G + + LL + IN +G +AL+ AA NG+ V+ L+ A ++
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQVNA 772
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TPL AAA G E +LL+ ANI+ + GQ P++ A +N E ++L L+
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
N + TT DG T H A G+V ++ LM + R +S +GG
Sbjct: 833 GTNRSVKTT-DGWTPVHAAVDTGNVDSLKLLM-YHRIPAHGNSFNEEESESSVFDLDGGE 890
Query: 1145 AD---VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ + +V A NR G TA H+AA G N L+++
Sbjct: 891 ESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEIL 932
Score = 77.8 bits (183), Expect = 4e-13
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 21/270 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T LQ AA G+ ++ +L+ G G +A++ AA++GHT+ + ++ S
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPL AA G E V L+S+ + A+ G TPL+LA
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-------------ADGGQTPLYLAC 818
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
NGN+ ++LLL AG + + G+ P+H A G++ + LL+ ++
Sbjct: 819 KNGNKECIKLLLE-AGTNRSVKTTD-GWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE 876
Query: 1313 GKTGLHIASTHGHYQMVEVL---LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC-ES 1368
++ + G + E + + IN ++ GWT H AA G N +++LC
Sbjct: 877 EESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G P+ N + A+++ +LE L
Sbjct: 937 GLEPERRDKCN-RTVHDVATDDCKHLLENL 965
Score = 70.1 bits (164), Expect = 8e-11
Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 6/129 (4%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y DG ++++AA+ GH + LL V+ + +T L A VE L+
Sbjct: 739 YSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS 798
Query: 718 YGADV-HIRGGKQRETPLHIAARIPDGDK-CALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y A++ H G Q TPL++A + +G+K C +LL++G + T DG TPVH A G
Sbjct: 799 YDANINHAADGGQ--TPLYLACK--NGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
Query: 776 NLATLVLLL 784
N+ +L LL+
Sbjct: 855 NVDSLKLLM 863
Score = 68.5 bits (160), Expect = 2e-10
Identities = 57/196 (29%), Positives = 94/196 (47%), Gaps = 10/196 (5%)
Query: 51 WKKLIRDLVFQRGKVPL-----LL--AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH 103
W + L+ G PL LL A GN +++ LL+ + + + + G +AL+
Sbjct: 691 WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLD-INYSCEDGHSALY 749
Query: 104 LAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE 163
AA+ D R+L+ A V+A + G TPL AAA+G V+ AN A +
Sbjct: 750 SAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG 809
Query: 164 DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
+TP++LA +NG+ I+LL + + +T DG T +H A G+ D +L +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEA-GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
Query: 224 LHMPNKYFEKQTFDEV 239
H N + E+++ V
Sbjct: 869 AH-GNSFNEEESESSV 883
Score = 68.5 bits (160), Expect = 2e-10
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 4/192 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G + L A GH V LL+ A+V+ D G + L AA G+ + + L++ A I
Sbjct: 744 GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI 803
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N A G+T L+LA NG +K L+ + V T TP+H A +G ++ KLL
Sbjct: 804 NHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Query: 1049 L--ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP-NLVMATTKDGNTCAHIAAI 1105
+ + A+ ++ +E + + P +L+ ++G T AHIAA
Sbjct: 863 MYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS 922
Query: 1106 QGSVKVIEELMK 1117
+G +E L +
Sbjct: 923 KGFKNCLEILCR 934
Score = 61.3 bits (142), Expect = 4e-08
Identities = 58/230 (25%), Positives = 105/230 (45%), Gaps = 30/230 (13%)
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
AAAQ N + ++ + L + + + +DG++ + AA G + L+ + ++A
Sbjct: 717 AAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--VNAA 773
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
+K N TPL AA GH + V +L+ A+ G T ++LA ++G+ + ++
Sbjct: 774 DK-NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTVKS-----------------EA 1229
T R G TP+H A G ++++ L+ H +P S E+
Sbjct: 833 GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEES 892
Query: 1230 PTGVSLVPVLGAE-------SGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
P G+S PV+ A+ G T H+AA G +N + +L G++ +
Sbjct: 893 PEGIS-KPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
Score = 56.8 bits (131), Expect = 8e-07
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 4/156 (2%)
Query: 997 TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID 1056
T L AA G L+ L+ + I+ + L+ AA +G + +LLL A ++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1057 ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
A D+ G P+ AAA + E V+L + N+ A G T ++A G+ + I+ L+
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-ADGGQTPLYLACKNGNKECIKLLL 830
Query: 1117 KFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+ G + + TP+ A + G+ D +++L+
Sbjct: 831 E---AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 56.0 bits (129), Expect = 1e-06
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 667 IHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+ AA G+V +++ LL ++G ++ + D ++AL+ A ++ V LL A V+
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA- 772
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
K TPL AA +C +L+ A N A + G TP+++A K GN + LLLE
Sbjct: 773 ADKNGFTPL-CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 786 DGGDPLRKT 794
G + KT
Sbjct: 832 AGTNRSVKT 840
Score = 47.2 bits (107), Expect = 6e-04
Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L E G D++ H +A + A G+ D + +++ +N + G+TPL
Sbjct: 730 LNEEGLDINYSCEDGH-SALYSAAKNGHTDCVRLLLS------AEAQVNAADKNGFTPLC 782
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
A +GH + V L++ A ++ G++ L+LA ++G + LL + K +
Sbjct: 783 AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD 842
Query: 995 GRTALHLAAMNGYAHLVKFLI 1015
G T +H A G +K L+
Sbjct: 843 GWTPVHAAVDTGNVDSLKLLM 863
Score = 44.4 bits (100), Expect = 0.004
Identities = 37/149 (24%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A + G+ I LL+ G + V T D +T +H AV++ ++ L+ +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA 869
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP---NKATEDGMTPVHVAAKFGNLAT 779
H + E+ + + G++ + K N A +G T H+AA G
Sbjct: 870 HGNSFNEEESESSV-FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNC 928
Query: 780 LVLLLEDGG-DPLRKTKV--CIYDVVTGE 805
L +L GG +P R+ K ++DV T +
Sbjct: 929 LEILCRHGGLEPERRDKCNRTVHDVATDD 957
Score = 35.1 bits (77), Expect = 2.7
Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 13/125 (10%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L+ AA+ D C +LL + A N A ++G TP+ AA G+ + LL+ +
Sbjct: 748 LYSAAKNGHTD-CVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN---- 802
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIE-----FVKDHKGESVSTAFIDAVDEDGA 848
+ G+TPL +AC++ + ++ L+E VK G + A +D + D
Sbjct: 803 ---INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL 859
Query: 849 SALHY 853
L Y
Sbjct: 860 KLLMY 864
>DQ388140-2|ABD72206.1| 1663|Homo sapiens CTTNBP2 protein.
Length = 1663
Score = 91.5 bits (217), Expect = 3e-17
Identities = 54/155 (34%), Positives = 85/155 (54%), Gaps = 2/155 (1%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
T L AA GN ++ +LLN G+ + S E+G++ L+ A GH V LLLS A++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINY-SCEDGHSALYSAAKNGHTDCVRLLLSAEAQV 770
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D++G T L A+ GH++ VE+L+ A IN G TPL+ A K G+ +KLL
Sbjct: 771 -NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
E+G + +T P+ A + D L+ L++
Sbjct: 830 LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY 864
Score = 87.8 bits (208), Expect = 4e-16
Identities = 68/223 (30%), Positives = 103/223 (46%), Gaps = 8/223 (3%)
Query: 966 LHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
L AA G + + LL + IN +G +AL+ AA NG+ V+ L+ A ++
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQVNA 772
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TPL AAA G E +LL+ ANI+ + GQ P++ A +N E ++L L+
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
N + TT DG T H A G+V ++ LM + R +S +GG
Sbjct: 833 GTNRSVKTT-DGWTPVHAAVDTGNVDSLKLLM-YHRIPAHGNSFNEEESESSVFDLDGGE 890
Query: 1145 AD---VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ + +V A NR G TA H+AA G N L+++
Sbjct: 891 ESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEIL 932
Score = 77.8 bits (183), Expect = 4e-13
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 21/270 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T LQ AA G+ ++ +L+ G G +A++ AA++GHT+ + ++ S
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPL AA G E V L+S+ + A+ G TPL+LA
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-------------ADGGQTPLYLAC 818
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
NGN+ ++LLL AG + + G+ P+H A G++ + LL+ ++
Sbjct: 819 KNGNKECIKLLLE-AGTNRSVKTTD-GWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE 876
Query: 1313 GKTGLHIASTHGHYQMVEVL---LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC-ES 1368
++ + G + E + + IN ++ GWT H AA G N +++LC
Sbjct: 877 EESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G P+ N + A+++ +LE L
Sbjct: 937 GLEPERRDKCN-RTVHDVATDDCKHLLENL 965
Score = 70.1 bits (164), Expect = 8e-11
Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 6/129 (4%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y DG ++++AA+ GH + LL V+ + +T L A VE L+
Sbjct: 739 YSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS 798
Query: 718 YGADV-HIRGGKQRETPLHIAARIPDGDK-CALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y A++ H G Q TPL++A + +G+K C +LL++G + T DG TPVH A G
Sbjct: 799 YDANINHAADGGQ--TPLYLACK--NGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
Query: 776 NLATLVLLL 784
N+ +L LL+
Sbjct: 855 NVDSLKLLM 863
Score = 68.5 bits (160), Expect = 2e-10
Identities = 57/196 (29%), Positives = 94/196 (47%), Gaps = 10/196 (5%)
Query: 51 WKKLIRDLVFQRGKVPL-----LL--AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH 103
W + L+ G PL LL A GN +++ LL+ + + + + G +AL+
Sbjct: 691 WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLD-INYSCEDGHSALY 749
Query: 104 LAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE 163
AA+ D R+L+ A V+A + G TPL AAA+G V+ AN A +
Sbjct: 750 SAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG 809
Query: 164 DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
+TP++LA +NG+ I+LL + + +T DG T +H A G+ D +L +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEA-GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
Query: 224 LHMPNKYFEKQTFDEV 239
H N + E+++ V
Sbjct: 869 AH-GNSFNEEESESSV 883
Score = 68.5 bits (160), Expect = 2e-10
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 4/192 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G + L A GH V LL+ A+V+ D G + L AA G+ + + L++ A I
Sbjct: 744 GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI 803
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N A G+T L+LA NG +K L+ + V T TP+H A +G ++ KLL
Sbjct: 804 NHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Query: 1049 L--ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP-NLVMATTKDGNTCAHIAAI 1105
+ + A+ ++ +E + + P +L+ ++G T AHIAA
Sbjct: 863 MYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS 922
Query: 1106 QGSVKVIEELMK 1117
+G +E L +
Sbjct: 923 KGFKNCLEILCR 934
Score = 61.3 bits (142), Expect = 4e-08
Identities = 58/230 (25%), Positives = 105/230 (45%), Gaps = 30/230 (13%)
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
AAAQ N + ++ + L + + + +DG++ + AA G + L+ + ++A
Sbjct: 717 AAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--VNAA 773
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
+K N TPL AA GH + V +L+ A+ G T ++LA ++G+ + ++
Sbjct: 774 DK-NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTVKS-----------------EA 1229
T R G TP+H A G ++++ L+ H +P S E+
Sbjct: 833 GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEES 892
Query: 1230 PTGVSLVPVLGAE-------SGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
P G+S PV+ A+ G T H+AA G +N + +L G++ +
Sbjct: 893 PEGIS-KPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
Score = 56.8 bits (131), Expect = 8e-07
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 4/156 (2%)
Query: 997 TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID 1056
T L AA G L+ L+ + I+ + L+ AA +G + +LLL A ++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1057 ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
A D+ G P+ AAA + E V+L + N+ A G T ++A G+ + I+ L+
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-ADGGQTPLYLACKNGNKECIKLLL 830
Query: 1117 KFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+ G + + TP+ A + G+ D +++L+
Sbjct: 831 E---AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 56.0 bits (129), Expect = 1e-06
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 667 IHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+ AA G+V +++ LL ++G ++ + D ++AL+ A ++ V LL A V+
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA- 772
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
K TPL AA +C +L+ A N A + G TP+++A K GN + LLLE
Sbjct: 773 ADKNGFTPL-CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 786 DGGDPLRKT 794
G + KT
Sbjct: 832 AGTNRSVKT 840
Score = 47.2 bits (107), Expect = 6e-04
Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L E G D++ H +A + A G+ D + +++ +N + G+TPL
Sbjct: 730 LNEEGLDINYSCEDGH-SALYSAAKNGHTDCVRLLLS------AEAQVNAADKNGFTPLC 782
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
A +GH + V L++ A ++ G++ L+LA ++G + LL + K +
Sbjct: 783 AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD 842
Query: 995 GRTALHLAAMNGYAHLVKFLI 1015
G T +H A G +K L+
Sbjct: 843 GWTPVHAAVDTGNVDSLKLLM 863
Score = 44.4 bits (100), Expect = 0.004
Identities = 37/149 (24%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A + G+ I LL+ G + V T D +T +H AV++ ++ L+ +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA 869
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP---NKATEDGMTPVHVAAKFGNLAT 779
H + E+ + + G++ + K N A +G T H+AA G
Sbjct: 870 HGNSFNEEESESSV-FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNC 928
Query: 780 LVLLLEDGG-DPLRKTKV--CIYDVVTGE 805
L +L GG +P R+ K ++DV T +
Sbjct: 929 LEILCRHGGLEPERRDKCNRTVHDVATDD 957
Score = 35.1 bits (77), Expect = 2.7
Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 13/125 (10%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L+ AA+ D C +LL + A N A ++G TP+ AA G+ + LL+ +
Sbjct: 748 LYSAAKNGHTD-CVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN---- 802
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIE-----FVKDHKGESVSTAFIDAVDEDGA 848
+ G+TPL +AC++ + ++ L+E VK G + A +D + D
Sbjct: 803 ---INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL 859
Query: 849 SALHY 853
L Y
Sbjct: 860 KLLMY 864
>DQ388139-2|ABD72204.1| 1663|Homo sapiens CTTNBP2 protein.
Length = 1663
Score = 91.5 bits (217), Expect = 3e-17
Identities = 54/155 (34%), Positives = 85/155 (54%), Gaps = 2/155 (1%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
T L AA GN ++ +LLN G+ + S E+G++ L+ A GH V LLLS A++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINY-SCEDGHSALYSAAKNGHTDCVRLLLSAEAQV 770
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D++G T L A+ GH++ VE+L+ A IN G TPL+ A K G+ +KLL
Sbjct: 771 -NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
E+G + +T P+ A + D L+ L++
Sbjct: 830 LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY 864
Score = 87.8 bits (208), Expect = 4e-16
Identities = 68/223 (30%), Positives = 103/223 (46%), Gaps = 8/223 (3%)
Query: 966 LHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
L AA G + + LL + IN +G +AL+ AA NG+ V+ L+ A ++
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQVNA 772
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TPL AAA G E +LL+ ANI+ + GQ P++ A +N E ++L L+
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
N + TT DG T H A G+V ++ LM + R +S +GG
Sbjct: 833 GTNRSVKTT-DGWTPVHAAVDTGNVDSLKLLM-YHRIPAHGNSFNEEESESSVFDLDGGE 890
Query: 1145 AD---VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ + +V A NR G TA H+AA G N L+++
Sbjct: 891 ESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEIL 932
Score = 77.8 bits (183), Expect = 4e-13
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 21/270 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T LQ AA G+ ++ +L+ G G +A++ AA++GHT+ + ++ S
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPL AA G E V L+S+ + A+ G TPL+LA
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-------------ADGGQTPLYLAC 818
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
NGN+ ++LLL AG + + G+ P+H A G++ + LL+ ++
Sbjct: 819 KNGNKECIKLLLE-AGTNRSVKTTD-GWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE 876
Query: 1313 GKTGLHIASTHGHYQMVEVL---LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC-ES 1368
++ + G + E + + IN ++ GWT H AA G N +++LC
Sbjct: 877 EESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G P+ N + A+++ +LE L
Sbjct: 937 GLEPERRDKCN-RTVHDVATDDCKHLLENL 965
Score = 70.1 bits (164), Expect = 8e-11
Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 6/129 (4%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y DG ++++AA+ GH + LL V+ + +T L A VE L+
Sbjct: 739 YSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS 798
Query: 718 YGADV-HIRGGKQRETPLHIAARIPDGDK-CALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y A++ H G Q TPL++A + +G+K C +LL++G + T DG TPVH A G
Sbjct: 799 YDANINHAADGGQ--TPLYLACK--NGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
Query: 776 NLATLVLLL 784
N+ +L LL+
Sbjct: 855 NVDSLKLLM 863
Score = 68.5 bits (160), Expect = 2e-10
Identities = 57/196 (29%), Positives = 94/196 (47%), Gaps = 10/196 (5%)
Query: 51 WKKLIRDLVFQRGKVPL-----LL--AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH 103
W + L+ G PL LL A GN +++ LL+ + + + + G +AL+
Sbjct: 691 WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLD-INYSCEDGHSALY 749
Query: 104 LAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE 163
AA+ D R+L+ A V+A + G TPL AAA+G V+ AN A +
Sbjct: 750 SAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG 809
Query: 164 DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
+TP++LA +NG+ I+LL + + +T DG T +H A G+ D +L +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEA-GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
Query: 224 LHMPNKYFEKQTFDEV 239
H N + E+++ V
Sbjct: 869 AH-GNSFNEEESESSV 883
Score = 68.5 bits (160), Expect = 2e-10
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 4/192 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G + L A GH V LL+ A+V+ D G + L AA G+ + + L++ A I
Sbjct: 744 GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI 803
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N A G+T L+LA NG +K L+ + V T TP+H A +G ++ KLL
Sbjct: 804 NHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Query: 1049 L--ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP-NLVMATTKDGNTCAHIAAI 1105
+ + A+ ++ +E + + P +L+ ++G T AHIAA
Sbjct: 863 MYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS 922
Query: 1106 QGSVKVIEELMK 1117
+G +E L +
Sbjct: 923 KGFKNCLEILCR 934
Score = 61.3 bits (142), Expect = 4e-08
Identities = 58/230 (25%), Positives = 105/230 (45%), Gaps = 30/230 (13%)
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
AAAQ N + ++ + L + + + +DG++ + AA G + L+ + ++A
Sbjct: 717 AAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--VNAA 773
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
+K N TPL AA GH + V +L+ A+ G T ++LA ++G+ + ++
Sbjct: 774 DK-NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTVKS-----------------EA 1229
T R G TP+H A G ++++ L+ H +P S E+
Sbjct: 833 GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEES 892
Query: 1230 PTGVSLVPVLGAE-------SGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
P G+S PV+ A+ G T H+AA G +N + +L G++ +
Sbjct: 893 PEGIS-KPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
Score = 56.8 bits (131), Expect = 8e-07
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 4/156 (2%)
Query: 997 TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID 1056
T L AA G L+ L+ + I+ + L+ AA +G + +LLL A ++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1057 ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
A D+ G P+ AAA + E V+L + N+ A G T ++A G+ + I+ L+
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-ADGGQTPLYLACKNGNKECIKLLL 830
Query: 1117 KFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+ G + + TP+ A + G+ D +++L+
Sbjct: 831 E---AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 56.0 bits (129), Expect = 1e-06
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 667 IHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+ AA G+V +++ LL ++G ++ + D ++AL+ A ++ V LL A V+
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA- 772
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
K TPL AA +C +L+ A N A + G TP+++A K GN + LLLE
Sbjct: 773 ADKNGFTPL-CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 786 DGGDPLRKT 794
G + KT
Sbjct: 832 AGTNRSVKT 840
Score = 47.2 bits (107), Expect = 6e-04
Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L E G D++ H +A + A G+ D + +++ +N + G+TPL
Sbjct: 730 LNEEGLDINYSCEDGH-SALYSAAKNGHTDCVRLLLS------AEAQVNAADKNGFTPLC 782
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
A +GH + V L++ A ++ G++ L+LA ++G + LL + K +
Sbjct: 783 AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD 842
Query: 995 GRTALHLAAMNGYAHLVKFLI 1015
G T +H A G +K L+
Sbjct: 843 GWTPVHAAVDTGNVDSLKLLM 863
Score = 44.4 bits (100), Expect = 0.004
Identities = 37/149 (24%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A + G+ I LL+ G + V T D +T +H AV++ ++ L+ +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA 869
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP---NKATEDGMTPVHVAAKFGNLAT 779
H + E+ + + G++ + K N A +G T H+AA G
Sbjct: 870 HGNSFNEEESESSV-FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNC 928
Query: 780 LVLLLEDGG-DPLRKTKV--CIYDVVTGE 805
L +L GG +P R+ K ++DV T +
Sbjct: 929 LEILCRHGGLEPERRDKCNRTVHDVATDD 957
Score = 35.1 bits (77), Expect = 2.7
Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 13/125 (10%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L+ AA+ D C +LL + A N A ++G TP+ AA G+ + LL+ +
Sbjct: 748 LYSAAKNGHTD-CVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN---- 802
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIE-----FVKDHKGESVSTAFIDAVDEDGA 848
+ G+TPL +AC++ + ++ L+E VK G + A +D + D
Sbjct: 803 ---INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL 859
Query: 849 SALHY 853
L Y
Sbjct: 860 KLLMY 864
>DQ388138-2|ABD72202.1| 1663|Homo sapiens CTTNBP2 protein.
Length = 1663
Score = 91.5 bits (217), Expect = 3e-17
Identities = 54/155 (34%), Positives = 85/155 (54%), Gaps = 2/155 (1%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
T L AA GN ++ +LLN G+ + S E+G++ L+ A GH V LLLS A++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINY-SCEDGHSALYSAAKNGHTDCVRLLLSAEAQV 770
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D++G T L A+ GH++ VE+L+ A IN G TPL+ A K G+ +KLL
Sbjct: 771 -NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
E+G + +T P+ A + D L+ L++
Sbjct: 830 LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY 864
Score = 87.8 bits (208), Expect = 4e-16
Identities = 68/223 (30%), Positives = 103/223 (46%), Gaps = 8/223 (3%)
Query: 966 LHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
L AA G + + LL + IN +G +AL+ AA NG+ V+ L+ A ++
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQVNA 772
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TPL AAA G E +LL+ ANI+ + GQ P++ A +N E ++L L+
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
N + TT DG T H A G+V ++ LM + R +S +GG
Sbjct: 833 GTNRSVKTT-DGWTPVHAAVDTGNVDSLKLLM-YHRIPAHGNSFNEEESESSVFDLDGGE 890
Query: 1145 AD---VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ + +V A NR G TA H+AA G N L+++
Sbjct: 891 ESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEIL 932
Score = 77.8 bits (183), Expect = 4e-13
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 21/270 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T LQ AA G+ ++ +L+ G G +A++ AA++GHT+ + ++ S
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPL AA G E V L+S+ + A+ G TPL+LA
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-------------ADGGQTPLYLAC 818
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
NGN+ ++LLL AG + + G+ P+H A G++ + LL+ ++
Sbjct: 819 KNGNKECIKLLLE-AGTNRSVKTTD-GWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE 876
Query: 1313 GKTGLHIASTHGHYQMVEVL---LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC-ES 1368
++ + G + E + + IN ++ GWT H AA G N +++LC
Sbjct: 877 EESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G P+ N + A+++ +LE L
Sbjct: 937 GLEPERRDKCN-RTVHDVATDDCKHLLENL 965
Score = 70.1 bits (164), Expect = 8e-11
Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 6/129 (4%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y DG ++++AA+ GH + LL V+ + +T L A VE L+
Sbjct: 739 YSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS 798
Query: 718 YGADV-HIRGGKQRETPLHIAARIPDGDK-CALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y A++ H G Q TPL++A + +G+K C +LL++G + T DG TPVH A G
Sbjct: 799 YDANINHAADGGQ--TPLYLACK--NGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
Query: 776 NLATLVLLL 784
N+ +L LL+
Sbjct: 855 NVDSLKLLM 863
Score = 68.5 bits (160), Expect = 2e-10
Identities = 57/196 (29%), Positives = 94/196 (47%), Gaps = 10/196 (5%)
Query: 51 WKKLIRDLVFQRGKVPL-----LL--AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH 103
W + L+ G PL LL A GN +++ LL+ + + + + G +AL+
Sbjct: 691 WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLD-INYSCEDGHSALY 749
Query: 104 LAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE 163
AA+ D R+L+ A V+A + G TPL AAA+G V+ AN A +
Sbjct: 750 SAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG 809
Query: 164 DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
+TP++LA +NG+ I+LL + + +T DG T +H A G+ D +L +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEA-GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
Query: 224 LHMPNKYFEKQTFDEV 239
H N + E+++ V
Sbjct: 869 AH-GNSFNEEESESSV 883
Score = 68.5 bits (160), Expect = 2e-10
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 4/192 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G + L A GH V LL+ A+V+ D G + L AA G+ + + L++ A I
Sbjct: 744 GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI 803
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N A G+T L+LA NG +K L+ + V T TP+H A +G ++ KLL
Sbjct: 804 NHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Query: 1049 L--ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP-NLVMATTKDGNTCAHIAAI 1105
+ + A+ ++ +E + + P +L+ ++G T AHIAA
Sbjct: 863 MYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS 922
Query: 1106 QGSVKVIEELMK 1117
+G +E L +
Sbjct: 923 KGFKNCLEILCR 934
Score = 61.3 bits (142), Expect = 4e-08
Identities = 58/230 (25%), Positives = 105/230 (45%), Gaps = 30/230 (13%)
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
AAAQ N + ++ + L + + + +DG++ + AA G + L+ + ++A
Sbjct: 717 AAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--VNAA 773
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
+K N TPL AA GH + V +L+ A+ G T ++LA ++G+ + ++
Sbjct: 774 DK-NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTVKS-----------------EA 1229
T R G TP+H A G ++++ L+ H +P S E+
Sbjct: 833 GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEES 892
Query: 1230 PTGVSLVPVLGAE-------SGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
P G+S PV+ A+ G T H+AA G +N + +L G++ +
Sbjct: 893 PEGIS-KPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
Score = 56.8 bits (131), Expect = 8e-07
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 4/156 (2%)
Query: 997 TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID 1056
T L AA G L+ L+ + I+ + L+ AA +G + +LLL A ++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1057 ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
A D+ G P+ AAA + E V+L + N+ A G T ++A G+ + I+ L+
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-ADGGQTPLYLACKNGNKECIKLLL 830
Query: 1117 KFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+ G + + TP+ A + G+ D +++L+
Sbjct: 831 E---AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 56.0 bits (129), Expect = 1e-06
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 667 IHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+ AA G+V +++ LL ++G ++ + D ++AL+ A ++ V LL A V+
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA- 772
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
K TPL AA +C +L+ A N A + G TP+++A K GN + LLLE
Sbjct: 773 ADKNGFTPL-CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 786 DGGDPLRKT 794
G + KT
Sbjct: 832 AGTNRSVKT 840
Score = 47.2 bits (107), Expect = 6e-04
Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L E G D++ H +A + A G+ D + +++ +N + G+TPL
Sbjct: 730 LNEEGLDINYSCEDGH-SALYSAAKNGHTDCVRLLLS------AEAQVNAADKNGFTPLC 782
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
A +GH + V L++ A ++ G++ L+LA ++G + LL + K +
Sbjct: 783 AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD 842
Query: 995 GRTALHLAAMNGYAHLVKFLI 1015
G T +H A G +K L+
Sbjct: 843 GWTPVHAAVDTGNVDSLKLLM 863
Score = 44.4 bits (100), Expect = 0.004
Identities = 37/149 (24%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A + G+ I LL+ G + V T D +T +H AV++ ++ L+ +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA 869
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP---NKATEDGMTPVHVAAKFGNLAT 779
H + E+ + + G++ + K N A +G T H+AA G
Sbjct: 870 HGNSFNEEESESSV-FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNC 928
Query: 780 LVLLLEDGG-DPLRKTKV--CIYDVVTGE 805
L +L GG +P R+ K ++DV T +
Sbjct: 929 LEILCRHGGLEPERRDKCNRTVHDVATDD 957
Score = 35.1 bits (77), Expect = 2.7
Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 13/125 (10%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L+ AA+ D C +LL + A N A ++G TP+ AA G+ + LL+ +
Sbjct: 748 LYSAAKNGHTD-CVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN---- 802
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIE-----FVKDHKGESVSTAFIDAVDEDGA 848
+ G+TPL +AC++ + ++ L+E VK G + A +D + D
Sbjct: 803 ---INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL 859
Query: 849 SALHY 853
L Y
Sbjct: 860 KLLMY 864
>DQ388137-2|ABD72200.1| 1663|Homo sapiens CTTNBP2 protein.
Length = 1663
Score = 91.5 bits (217), Expect = 3e-17
Identities = 54/155 (34%), Positives = 85/155 (54%), Gaps = 2/155 (1%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
T L AA GN ++ +LLN G+ + S E+G++ L+ A GH V LLLS A++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINY-SCEDGHSALYSAAKNGHTDCVRLLLSAEAQV 770
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D++G T L A+ GH++ VE+L+ A IN G TPL+ A K G+ +KLL
Sbjct: 771 -NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
E+G + +T P+ A + D L+ L++
Sbjct: 830 LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY 864
Score = 87.8 bits (208), Expect = 4e-16
Identities = 68/223 (30%), Positives = 103/223 (46%), Gaps = 8/223 (3%)
Query: 966 LHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
L AA G + + LL + IN +G +AL+ AA NG+ V+ L+ A ++
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQVNA 772
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TPL AAA G E +LL+ ANI+ + GQ P++ A +N E ++L L+
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
N + TT DG T H A G+V ++ LM + R +S +GG
Sbjct: 833 GTNRSVKTT-DGWTPVHAAVDTGNVDSLKLLM-YHRIPAHGNSFNEEESESSVFDLDGGE 890
Query: 1145 AD---VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ + +V A NR G TA H+AA G N L+++
Sbjct: 891 ESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEIL 932
Score = 77.8 bits (183), Expect = 4e-13
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 21/270 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T LQ AA G+ ++ +L+ G G +A++ AA++GHT+ + ++ S
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPL AA G E V L+S+ + A+ G TPL+LA
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-------------ADGGQTPLYLAC 818
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
NGN+ ++LLL AG + + G+ P+H A G++ + LL+ ++
Sbjct: 819 KNGNKECIKLLLE-AGTNRSVKTTD-GWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE 876
Query: 1313 GKTGLHIASTHGHYQMVEVL---LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC-ES 1368
++ + G + E + + IN ++ GWT H AA G N +++LC
Sbjct: 877 EESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G P+ N + A+++ +LE L
Sbjct: 937 GLEPERRDKCN-RTVHDVATDDCKHLLENL 965
Score = 70.1 bits (164), Expect = 8e-11
Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 6/129 (4%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y DG ++++AA+ GH + LL V+ + +T L A VE L+
Sbjct: 739 YSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS 798
Query: 718 YGADV-HIRGGKQRETPLHIAARIPDGDK-CALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y A++ H G Q TPL++A + +G+K C +LL++G + T DG TPVH A G
Sbjct: 799 YDANINHAADGGQ--TPLYLACK--NGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
Query: 776 NLATLVLLL 784
N+ +L LL+
Sbjct: 855 NVDSLKLLM 863
Score = 68.5 bits (160), Expect = 2e-10
Identities = 57/196 (29%), Positives = 94/196 (47%), Gaps = 10/196 (5%)
Query: 51 WKKLIRDLVFQRGKVPL-----LL--AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH 103
W + L+ G PL LL A GN +++ LL+ + + + + G +AL+
Sbjct: 691 WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLD-INYSCEDGHSALY 749
Query: 104 LAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE 163
AA+ D R+L+ A V+A + G TPL AAA+G V+ AN A +
Sbjct: 750 SAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG 809
Query: 164 DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
+TP++LA +NG+ I+LL + + +T DG T +H A G+ D +L +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEA-GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
Query: 224 LHMPNKYFEKQTFDEV 239
H N + E+++ V
Sbjct: 869 AH-GNSFNEEESESSV 883
Score = 68.5 bits (160), Expect = 2e-10
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 4/192 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G + L A GH V LL+ A+V+ D G + L AA G+ + + L++ A I
Sbjct: 744 GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI 803
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N A G+T L+LA NG +K L+ + V T TP+H A +G ++ KLL
Sbjct: 804 NHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Query: 1049 L--ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP-NLVMATTKDGNTCAHIAAI 1105
+ + A+ ++ +E + + P +L+ ++G T AHIAA
Sbjct: 863 MYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS 922
Query: 1106 QGSVKVIEELMK 1117
+G +E L +
Sbjct: 923 KGFKNCLEILCR 934
Score = 61.3 bits (142), Expect = 4e-08
Identities = 58/230 (25%), Positives = 105/230 (45%), Gaps = 30/230 (13%)
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
AAAQ N + ++ + L + + + +DG++ + AA G + L+ + ++A
Sbjct: 717 AAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--VNAA 773
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
+K N TPL AA GH + V +L+ A+ G T ++LA ++G+ + ++
Sbjct: 774 DK-NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTVKS-----------------EA 1229
T R G TP+H A G ++++ L+ H +P S E+
Sbjct: 833 GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEES 892
Query: 1230 PTGVSLVPVLGAE-------SGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
P G+S PV+ A+ G T H+AA G +N + +L G++ +
Sbjct: 893 PEGIS-KPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
Score = 56.8 bits (131), Expect = 8e-07
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 4/156 (2%)
Query: 997 TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID 1056
T L AA G L+ L+ + I+ + L+ AA +G + +LLL A ++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1057 ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
A D+ G P+ AAA + E V+L + N+ A G T ++A G+ + I+ L+
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-ADGGQTPLYLACKNGNKECIKLLL 830
Query: 1117 KFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+ G + + TP+ A + G+ D +++L+
Sbjct: 831 E---AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 56.0 bits (129), Expect = 1e-06
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 667 IHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+ AA G+V +++ LL ++G ++ + D ++AL+ A ++ V LL A V+
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA- 772
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
K TPL AA +C +L+ A N A + G TP+++A K GN + LLLE
Sbjct: 773 ADKNGFTPL-CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 786 DGGDPLRKT 794
G + KT
Sbjct: 832 AGTNRSVKT 840
Score = 47.2 bits (107), Expect = 6e-04
Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L E G D++ H +A + A G+ D + +++ +N + G+TPL
Sbjct: 730 LNEEGLDINYSCEDGH-SALYSAAKNGHTDCVRLLLS------AEAQVNAADKNGFTPLC 782
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
A +GH + V L++ A ++ G++ L+LA ++G + LL + K +
Sbjct: 783 AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD 842
Query: 995 GRTALHLAAMNGYAHLVKFLI 1015
G T +H A G +K L+
Sbjct: 843 GWTPVHAAVDTGNVDSLKLLM 863
Score = 44.4 bits (100), Expect = 0.004
Identities = 37/149 (24%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A + G+ I LL+ G + V T D +T +H AV++ ++ L+ +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA 869
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP---NKATEDGMTPVHVAAKFGNLAT 779
H + E+ + + G++ + K N A +G T H+AA G
Sbjct: 870 HGNSFNEEESESSV-FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNC 928
Query: 780 LVLLLEDGG-DPLRKTKV--CIYDVVTGE 805
L +L GG +P R+ K ++DV T +
Sbjct: 929 LEILCRHGGLEPERRDKCNRTVHDVATDD 957
Score = 35.1 bits (77), Expect = 2.7
Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 13/125 (10%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L+ AA+ D C +LL + A N A ++G TP+ AA G+ + LL+ +
Sbjct: 748 LYSAAKNGHTD-CVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN---- 802
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIE-----FVKDHKGESVSTAFIDAVDEDGA 848
+ G+TPL +AC++ + ++ L+E VK G + A +D + D
Sbjct: 803 ---INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL 859
Query: 849 SALHY 853
L Y
Sbjct: 860 KLLMY 864
>DQ388136-2|ABD72198.1| 1663|Homo sapiens CTTNBP2 protein.
Length = 1663
Score = 91.5 bits (217), Expect = 3e-17
Identities = 54/155 (34%), Positives = 85/155 (54%), Gaps = 2/155 (1%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
T L AA GN ++ +LLN G+ + S E+G++ L+ A GH V LLLS A++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINY-SCEDGHSALYSAAKNGHTDCVRLLLSAEAQV 770
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D++G T L A+ GH++ VE+L+ A IN G TPL+ A K G+ +KLL
Sbjct: 771 -NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
E+G + +T P+ A + D L+ L++
Sbjct: 830 LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY 864
Score = 87.8 bits (208), Expect = 4e-16
Identities = 68/223 (30%), Positives = 103/223 (46%), Gaps = 8/223 (3%)
Query: 966 LHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
L AA G + + LL + IN +G +AL+ AA NG+ V+ L+ A ++
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQVNA 772
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TPL AAA G E +LL+ ANI+ + GQ P++ A +N E ++L L+
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
N + TT DG T H A G+V ++ LM + R +S +GG
Sbjct: 833 GTNRSVKTT-DGWTPVHAAVDTGNVDSLKLLM-YHRIPAHGNSFNEEESESSVFDLDGGE 890
Query: 1145 AD---VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ + +V A NR G TA H+AA G N L+++
Sbjct: 891 ESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEIL 932
Score = 77.8 bits (183), Expect = 4e-13
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 21/270 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T LQ AA G+ ++ +L+ G G +A++ AA++GHT+ + ++ S
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPL AA G E V L+S+ + A+ G TPL+LA
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-------------ADGGQTPLYLAC 818
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
NGN+ ++LLL AG + + G+ P+H A G++ + LL+ ++
Sbjct: 819 KNGNKECIKLLLE-AGTNRSVKTTD-GWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE 876
Query: 1313 GKTGLHIASTHGHYQMVEVL---LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC-ES 1368
++ + G + E + + IN ++ GWT H AA G N +++LC
Sbjct: 877 EESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G P+ N + A+++ +LE L
Sbjct: 937 GLEPERRDKCN-RTVHDVATDDCKHLLENL 965
Score = 70.1 bits (164), Expect = 8e-11
Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 6/129 (4%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y DG ++++AA+ GH + LL V+ + +T L A VE L+
Sbjct: 739 YSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS 798
Query: 718 YGADV-HIRGGKQRETPLHIAARIPDGDK-CALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y A++ H G Q TPL++A + +G+K C +LL++G + T DG TPVH A G
Sbjct: 799 YDANINHAADGGQ--TPLYLACK--NGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
Query: 776 NLATLVLLL 784
N+ +L LL+
Sbjct: 855 NVDSLKLLM 863
Score = 68.5 bits (160), Expect = 2e-10
Identities = 57/196 (29%), Positives = 94/196 (47%), Gaps = 10/196 (5%)
Query: 51 WKKLIRDLVFQRGKVPL-----LL--AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH 103
W + L+ G PL LL A GN +++ LL+ + + + + G +AL+
Sbjct: 691 WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLD-INYSCEDGHSALY 749
Query: 104 LAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE 163
AA+ D R+L+ A V+A + G TPL AAA+G V+ AN A +
Sbjct: 750 SAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG 809
Query: 164 DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
+TP++LA +NG+ I+LL + + +T DG T +H A G+ D +L +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEA-GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
Query: 224 LHMPNKYFEKQTFDEV 239
H N + E+++ V
Sbjct: 869 AH-GNSFNEEESESSV 883
Score = 68.5 bits (160), Expect = 2e-10
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 4/192 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G + L A GH V LL+ A+V+ D G + L AA G+ + + L++ A I
Sbjct: 744 GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI 803
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N A G+T L+LA NG +K L+ + V T TP+H A +G ++ KLL
Sbjct: 804 NHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Query: 1049 L--ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP-NLVMATTKDGNTCAHIAAI 1105
+ + A+ ++ +E + + P +L+ ++G T AHIAA
Sbjct: 863 MYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS 922
Query: 1106 QGSVKVIEELMK 1117
+G +E L +
Sbjct: 923 KGFKNCLEILCR 934
Score = 61.3 bits (142), Expect = 4e-08
Identities = 58/230 (25%), Positives = 105/230 (45%), Gaps = 30/230 (13%)
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
AAAQ N + ++ + L + + + +DG++ + AA G + L+ + ++A
Sbjct: 717 AAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--VNAA 773
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
+K N TPL AA GH + V +L+ A+ G T ++LA ++G+ + ++
Sbjct: 774 DK-NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTVKS-----------------EA 1229
T R G TP+H A G ++++ L+ H +P S E+
Sbjct: 833 GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEES 892
Query: 1230 PTGVSLVPVLGAE-------SGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
P G+S PV+ A+ G T H+AA G +N + +L G++ +
Sbjct: 893 PEGIS-KPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
Score = 56.8 bits (131), Expect = 8e-07
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 4/156 (2%)
Query: 997 TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID 1056
T L AA G L+ L+ + I+ + L+ AA +G + +LLL A ++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1057 ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
A D+ G P+ AAA + E V+L + N+ A G T ++A G+ + I+ L+
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-ADGGQTPLYLACKNGNKECIKLLL 830
Query: 1117 KFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+ G + + TP+ A + G+ D +++L+
Sbjct: 831 E---AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 56.0 bits (129), Expect = 1e-06
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 667 IHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+ AA G+V +++ LL ++G ++ + D ++AL+ A ++ V LL A V+
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA- 772
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
K TPL AA +C +L+ A N A + G TP+++A K GN + LLLE
Sbjct: 773 ADKNGFTPL-CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 786 DGGDPLRKT 794
G + KT
Sbjct: 832 AGTNRSVKT 840
Score = 47.2 bits (107), Expect = 6e-04
Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L E G D++ H +A + A G+ D + +++ +N + G+TPL
Sbjct: 730 LNEEGLDINYSCEDGH-SALYSAAKNGHTDCVRLLLS------AEAQVNAADKNGFTPLC 782
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
A +GH + V L++ A ++ G++ L+LA ++G + LL + K +
Sbjct: 783 AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD 842
Query: 995 GRTALHLAAMNGYAHLVKFLI 1015
G T +H A G +K L+
Sbjct: 843 GWTPVHAAVDTGNVDSLKLLM 863
Score = 44.4 bits (100), Expect = 0.004
Identities = 37/149 (24%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A + G+ I LL+ G + V T D +T +H AV++ ++ L+ +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA 869
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP---NKATEDGMTPVHVAAKFGNLAT 779
H + E+ + + G++ + K N A +G T H+AA G
Sbjct: 870 HGNSFNEEESESSV-FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNC 928
Query: 780 LVLLLEDGG-DPLRKTKV--CIYDVVTGE 805
L +L GG +P R+ K ++DV T +
Sbjct: 929 LEILCRHGGLEPERRDKCNRTVHDVATDD 957
Score = 35.1 bits (77), Expect = 2.7
Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 13/125 (10%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L+ AA+ D C +LL + A N A ++G TP+ AA G+ + LL+ +
Sbjct: 748 LYSAAKNGHTD-CVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN---- 802
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIE-----FVKDHKGESVSTAFIDAVDEDGA 848
+ G+TPL +AC++ + ++ L+E VK G + A +D + D
Sbjct: 803 ---INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL 859
Query: 849 SALHY 853
L Y
Sbjct: 860 KLLMY 864
>DQ388135-2|ABD72196.1| 1663|Homo sapiens CTTNBP2 protein.
Length = 1663
Score = 91.5 bits (217), Expect = 3e-17
Identities = 54/155 (34%), Positives = 85/155 (54%), Gaps = 2/155 (1%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
T L AA GN ++ +LLN G+ + S E+G++ L+ A GH V LLLS A++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINY-SCEDGHSALYSAAKNGHTDCVRLLLSAEAQV 770
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D++G T L A+ GH++ VE+L+ A IN G TPL+ A K G+ +KLL
Sbjct: 771 -NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
E+G + +T P+ A + D L+ L++
Sbjct: 830 LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY 864
Score = 87.8 bits (208), Expect = 4e-16
Identities = 68/223 (30%), Positives = 103/223 (46%), Gaps = 8/223 (3%)
Query: 966 LHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
L AA G + + LL + IN +G +AL+ AA NG+ V+ L+ A ++
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQVNA 772
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TPL AAA G E +LL+ ANI+ + GQ P++ A +N E ++L L+
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
N + TT DG T H A G+V ++ LM + R +S +GG
Sbjct: 833 GTNRSVKTT-DGWTPVHAAVDTGNVDSLKLLM-YHRIPAHGNSFNEEESESSVFDLDGGE 890
Query: 1145 AD---VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ + +V A NR G TA H+AA G N L+++
Sbjct: 891 ESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEIL 932
Score = 77.8 bits (183), Expect = 4e-13
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 21/270 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T LQ AA G+ ++ +L+ G G +A++ AA++GHT+ + ++ S
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPL AA G E V L+S+ + A+ G TPL+LA
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-------------ADGGQTPLYLAC 818
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
NGN+ ++LLL AG + + G+ P+H A G++ + LL+ ++
Sbjct: 819 KNGNKECIKLLLE-AGTNRSVKTTD-GWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE 876
Query: 1313 GKTGLHIASTHGHYQMVEVL---LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC-ES 1368
++ + G + E + + IN ++ GWT H AA G N +++LC
Sbjct: 877 EESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G P+ N + A+++ +LE L
Sbjct: 937 GLEPERRDKCN-RTVHDVATDDCKHLLENL 965
Score = 70.1 bits (164), Expect = 8e-11
Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 6/129 (4%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y DG ++++AA+ GH + LL V+ + +T L A VE L+
Sbjct: 739 YSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS 798
Query: 718 YGADV-HIRGGKQRETPLHIAARIPDGDK-CALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y A++ H G Q TPL++A + +G+K C +LL++G + T DG TPVH A G
Sbjct: 799 YDANINHAADGGQ--TPLYLACK--NGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
Query: 776 NLATLVLLL 784
N+ +L LL+
Sbjct: 855 NVDSLKLLM 863
Score = 68.5 bits (160), Expect = 2e-10
Identities = 57/196 (29%), Positives = 94/196 (47%), Gaps = 10/196 (5%)
Query: 51 WKKLIRDLVFQRGKVPL-----LL--AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH 103
W + L+ G PL LL A GN +++ LL+ + + + + G +AL+
Sbjct: 691 WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLD-INYSCEDGHSALY 749
Query: 104 LAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE 163
AA+ D R+L+ A V+A + G TPL AAA+G V+ AN A +
Sbjct: 750 SAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG 809
Query: 164 DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
+TP++LA +NG+ I+LL + + +T DG T +H A G+ D +L +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEA-GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
Query: 224 LHMPNKYFEKQTFDEV 239
H N + E+++ V
Sbjct: 869 AH-GNSFNEEESESSV 883
Score = 68.5 bits (160), Expect = 2e-10
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 4/192 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G + L A GH V LL+ A+V+ D G + L AA G+ + + L++ A I
Sbjct: 744 GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI 803
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N A G+T L+LA NG +K L+ + V T TP+H A +G ++ KLL
Sbjct: 804 NHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Query: 1049 L--ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP-NLVMATTKDGNTCAHIAAI 1105
+ + A+ ++ +E + + P +L+ ++G T AHIAA
Sbjct: 863 MYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS 922
Query: 1106 QGSVKVIEELMK 1117
+G +E L +
Sbjct: 923 KGFKNCLEILCR 934
Score = 61.3 bits (142), Expect = 4e-08
Identities = 58/230 (25%), Positives = 105/230 (45%), Gaps = 30/230 (13%)
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
AAAQ N + ++ + L + + + +DG++ + AA G + L+ + ++A
Sbjct: 717 AAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--VNAA 773
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
+K N TPL AA GH + V +L+ A+ G T ++LA ++G+ + ++
Sbjct: 774 DK-NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTVKS-----------------EA 1229
T R G TP+H A G ++++ L+ H +P S E+
Sbjct: 833 GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEES 892
Query: 1230 PTGVSLVPVLGAE-------SGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
P G+S PV+ A+ G T H+AA G +N + +L G++ +
Sbjct: 893 PEGIS-KPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
Score = 56.8 bits (131), Expect = 8e-07
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 4/156 (2%)
Query: 997 TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID 1056
T L AA G L+ L+ + I+ + L+ AA +G + +LLL A ++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1057 ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
A D+ G P+ AAA + E V+L + N+ A G T ++A G+ + I+ L+
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-ADGGQTPLYLACKNGNKECIKLLL 830
Query: 1117 KFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+ G + + TP+ A + G+ D +++L+
Sbjct: 831 E---AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 56.0 bits (129), Expect = 1e-06
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 667 IHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+ AA G+V +++ LL ++G ++ + D ++AL+ A ++ V LL A V+
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA- 772
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
K TPL AA +C +L+ A N A + G TP+++A K GN + LLLE
Sbjct: 773 ADKNGFTPL-CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 786 DGGDPLRKT 794
G + KT
Sbjct: 832 AGTNRSVKT 840
Score = 47.2 bits (107), Expect = 6e-04
Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L E G D++ H +A + A G+ D + +++ +N + G+TPL
Sbjct: 730 LNEEGLDINYSCEDGH-SALYSAAKNGHTDCVRLLLS------AEAQVNAADKNGFTPLC 782
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
A +GH + V L++ A ++ G++ L+LA ++G + LL + K +
Sbjct: 783 AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD 842
Query: 995 GRTALHLAAMNGYAHLVKFLI 1015
G T +H A G +K L+
Sbjct: 843 GWTPVHAAVDTGNVDSLKLLM 863
Score = 44.4 bits (100), Expect = 0.004
Identities = 37/149 (24%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A + G+ I LL+ G + V T D +T +H AV++ ++ L+ +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA 869
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP---NKATEDGMTPVHVAAKFGNLAT 779
H + E+ + + G++ + K N A +G T H+AA G
Sbjct: 870 HGNSFNEEESESSV-FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNC 928
Query: 780 LVLLLEDGG-DPLRKTKV--CIYDVVTGE 805
L +L GG +P R+ K ++DV T +
Sbjct: 929 LEILCRHGGLEPERRDKCNRTVHDVATDD 957
Score = 35.1 bits (77), Expect = 2.7
Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 13/125 (10%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L+ AA+ D C +LL + A N A ++G TP+ AA G+ + LL+ +
Sbjct: 748 LYSAAKNGHTD-CVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN---- 802
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIE-----FVKDHKGESVSTAFIDAVDEDGA 848
+ G+TPL +AC++ + ++ L+E VK G + A +D + D
Sbjct: 803 ---INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL 859
Query: 849 SALHY 853
L Y
Sbjct: 860 KLLMY 864
>DQ388134-2|ABD72194.1| 1663|Homo sapiens CTTNBP2 protein.
Length = 1663
Score = 91.5 bits (217), Expect = 3e-17
Identities = 54/155 (34%), Positives = 85/155 (54%), Gaps = 2/155 (1%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
T L AA GN ++ +LLN G+ + S E+G++ L+ A GH V LLLS A++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINY-SCEDGHSALYSAAKNGHTDCVRLLLSAEAQV 770
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D++G T L A+ GH++ VE+L+ A IN G TPL+ A K G+ +KLL
Sbjct: 771 -NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
E+G + +T P+ A + D L+ L++
Sbjct: 830 LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY 864
Score = 87.8 bits (208), Expect = 4e-16
Identities = 68/223 (30%), Positives = 103/223 (46%), Gaps = 8/223 (3%)
Query: 966 LHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
L AA G + + LL + IN +G +AL+ AA NG+ V+ L+ A ++
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQVNA 772
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TPL AAA G E +LL+ ANI+ + GQ P++ A +N E ++L L+
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
N + TT DG T H A G+V ++ LM + R +S +GG
Sbjct: 833 GTNRSVKTT-DGWTPVHAAVDTGNVDSLKLLM-YHRIPAHGNSFNEEESESSVFDLDGGE 890
Query: 1145 AD---VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ + +V A NR G TA H+AA G N L+++
Sbjct: 891 ESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEIL 932
Score = 77.8 bits (183), Expect = 4e-13
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 21/270 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T LQ AA G+ ++ +L+ G G +A++ AA++GHT+ + ++ S
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPL AA G E V L+S+ + A+ G TPL+LA
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-------------ADGGQTPLYLAC 818
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
NGN+ ++LLL AG + + G+ P+H A G++ + LL+ ++
Sbjct: 819 KNGNKECIKLLLE-AGTNRSVKTTD-GWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE 876
Query: 1313 GKTGLHIASTHGHYQMVEVL---LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC-ES 1368
++ + G + E + + IN ++ GWT H AA G N +++LC
Sbjct: 877 EESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G P+ N + A+++ +LE L
Sbjct: 937 GLEPERRDKCN-RTVHDVATDDCKHLLENL 965
Score = 70.1 bits (164), Expect = 8e-11
Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 6/129 (4%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y DG ++++AA+ GH + LL V+ + +T L A VE L+
Sbjct: 739 YSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS 798
Query: 718 YGADV-HIRGGKQRETPLHIAARIPDGDK-CALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y A++ H G Q TPL++A + +G+K C +LL++G + T DG TPVH A G
Sbjct: 799 YDANINHAADGGQ--TPLYLACK--NGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
Query: 776 NLATLVLLL 784
N+ +L LL+
Sbjct: 855 NVDSLKLLM 863
Score = 68.5 bits (160), Expect = 2e-10
Identities = 57/196 (29%), Positives = 94/196 (47%), Gaps = 10/196 (5%)
Query: 51 WKKLIRDLVFQRGKVPL-----LL--AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH 103
W + L+ G PL LL A GN +++ LL+ + + + + G +AL+
Sbjct: 691 WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLD-INYSCEDGHSALY 749
Query: 104 LAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE 163
AA+ D R+L+ A V+A + G TPL AAA+G V+ AN A +
Sbjct: 750 SAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG 809
Query: 164 DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
+TP++LA +NG+ I+LL + + +T DG T +H A G+ D +L +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEA-GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
Query: 224 LHMPNKYFEKQTFDEV 239
H N + E+++ V
Sbjct: 869 AH-GNSFNEEESESSV 883
Score = 68.5 bits (160), Expect = 2e-10
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 4/192 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G + L A GH V LL+ A+V+ D G + L AA G+ + + L++ A I
Sbjct: 744 GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI 803
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N A G+T L+LA NG +K L+ + V T TP+H A +G ++ KLL
Sbjct: 804 NHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Query: 1049 L--ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP-NLVMATTKDGNTCAHIAAI 1105
+ + A+ ++ +E + + P +L+ ++G T AHIAA
Sbjct: 863 MYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS 922
Query: 1106 QGSVKVIEELMK 1117
+G +E L +
Sbjct: 923 KGFKNCLEILCR 934
Score = 61.3 bits (142), Expect = 4e-08
Identities = 58/230 (25%), Positives = 105/230 (45%), Gaps = 30/230 (13%)
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
AAAQ N + ++ + L + + + +DG++ + AA G + L+ + ++A
Sbjct: 717 AAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--VNAA 773
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
+K N TPL AA GH + V +L+ A+ G T ++LA ++G+ + ++
Sbjct: 774 DK-NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTVKS-----------------EA 1229
T R G TP+H A G ++++ L+ H +P S E+
Sbjct: 833 GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEES 892
Query: 1230 PTGVSLVPVLGAE-------SGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
P G+S PV+ A+ G T H+AA G +N + +L G++ +
Sbjct: 893 PEGIS-KPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
Score = 56.8 bits (131), Expect = 8e-07
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 4/156 (2%)
Query: 997 TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID 1056
T L AA G L+ L+ + I+ + L+ AA +G + +LLL A ++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1057 ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
A D+ G P+ AAA + E V+L + N+ A G T ++A G+ + I+ L+
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-ADGGQTPLYLACKNGNKECIKLLL 830
Query: 1117 KFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+ G + + TP+ A + G+ D +++L+
Sbjct: 831 E---AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 56.0 bits (129), Expect = 1e-06
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 667 IHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+ AA G+V +++ LL ++G ++ + D ++AL+ A ++ V LL A V+
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA- 772
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
K TPL AA +C +L+ A N A + G TP+++A K GN + LLLE
Sbjct: 773 ADKNGFTPL-CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 786 DGGDPLRKT 794
G + KT
Sbjct: 832 AGTNRSVKT 840
Score = 47.2 bits (107), Expect = 6e-04
Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L E G D++ H +A + A G+ D + +++ +N + G+TPL
Sbjct: 730 LNEEGLDINYSCEDGH-SALYSAAKNGHTDCVRLLLS------AEAQVNAADKNGFTPLC 782
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
A +GH + V L++ A ++ G++ L+LA ++G + LL + K +
Sbjct: 783 AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD 842
Query: 995 GRTALHLAAMNGYAHLVKFLI 1015
G T +H A G +K L+
Sbjct: 843 GWTPVHAAVDTGNVDSLKLLM 863
Score = 44.4 bits (100), Expect = 0.004
Identities = 37/149 (24%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A + G+ I LL+ G + V T D +T +H AV++ ++ L+ +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA 869
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP---NKATEDGMTPVHVAAKFGNLAT 779
H + E+ + + G++ + K N A +G T H+AA G
Sbjct: 870 HGNSFNEEESESSV-FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNC 928
Query: 780 LVLLLEDGG-DPLRKTKV--CIYDVVTGE 805
L +L GG +P R+ K ++DV T +
Sbjct: 929 LEILCRHGGLEPERRDKCNRTVHDVATDD 957
Score = 35.1 bits (77), Expect = 2.7
Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 13/125 (10%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L+ AA+ D C +LL + A N A ++G TP+ AA G+ + LL+ +
Sbjct: 748 LYSAAKNGHTD-CVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN---- 802
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIE-----FVKDHKGESVSTAFIDAVDEDGA 848
+ G+TPL +AC++ + ++ L+E VK G + A +D + D
Sbjct: 803 ---INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL 859
Query: 849 SALHY 853
L Y
Sbjct: 860 KLLMY 864
>DQ388133-2|ABD72192.1| 1663|Homo sapiens CTTNBP2 protein.
Length = 1663
Score = 91.5 bits (217), Expect = 3e-17
Identities = 54/155 (34%), Positives = 85/155 (54%), Gaps = 2/155 (1%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
T L AA GN ++ +LLN G+ + S E+G++ L+ A GH V LLLS A++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINY-SCEDGHSALYSAAKNGHTDCVRLLLSAEAQV 770
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D++G T L A+ GH++ VE+L+ A IN G TPL+ A K G+ +KLL
Sbjct: 771 -NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
E+G + +T P+ A + D L+ L++
Sbjct: 830 LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY 864
Score = 87.8 bits (208), Expect = 4e-16
Identities = 68/223 (30%), Positives = 103/223 (46%), Gaps = 8/223 (3%)
Query: 966 LHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
L AA G + + LL + IN +G +AL+ AA NG+ V+ L+ A ++
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQVNA 772
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TPL AAA G E +LL+ ANI+ + GQ P++ A +N E ++L L+
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
N + TT DG T H A G+V ++ LM + R +S +GG
Sbjct: 833 GTNRSVKTT-DGWTPVHAAVDTGNVDSLKLLM-YHRIPAHGNSFNEEESESSVFDLDGGE 890
Query: 1145 AD---VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ + +V A NR G TA H+AA G N L+++
Sbjct: 891 ESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEIL 932
Score = 77.8 bits (183), Expect = 4e-13
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 21/270 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T LQ AA G+ ++ +L+ G G +A++ AA++GHT+ + ++ S
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPL AA G E V L+S+ + A+ G TPL+LA
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-------------ADGGQTPLYLAC 818
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
NGN+ ++LLL AG + + G+ P+H A G++ + LL+ ++
Sbjct: 819 KNGNKECIKLLLE-AGTNRSVKTTD-GWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE 876
Query: 1313 GKTGLHIASTHGHYQMVEVL---LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC-ES 1368
++ + G + E + + IN ++ GWT H AA G N +++LC
Sbjct: 877 EESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G P+ N + A+++ +LE L
Sbjct: 937 GLEPERRDKCN-RTVHDVATDDCKHLLENL 965
Score = 70.1 bits (164), Expect = 8e-11
Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 6/129 (4%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y DG ++++AA+ GH + LL V+ + +T L A VE L+
Sbjct: 739 YSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS 798
Query: 718 YGADV-HIRGGKQRETPLHIAARIPDGDK-CALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y A++ H G Q TPL++A + +G+K C +LL++G + T DG TPVH A G
Sbjct: 799 YDANINHAADGGQ--TPLYLACK--NGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
Query: 776 NLATLVLLL 784
N+ +L LL+
Sbjct: 855 NVDSLKLLM 863
Score = 68.5 bits (160), Expect = 2e-10
Identities = 57/196 (29%), Positives = 94/196 (47%), Gaps = 10/196 (5%)
Query: 51 WKKLIRDLVFQRGKVPL-----LL--AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH 103
W + L+ G PL LL A GN +++ LL+ + + + + G +AL+
Sbjct: 691 WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLD-INYSCEDGHSALY 749
Query: 104 LAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE 163
AA+ D R+L+ A V+A + G TPL AAA+G V+ AN A +
Sbjct: 750 SAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG 809
Query: 164 DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
+TP++LA +NG+ I+LL + + +T DG T +H A G+ D +L +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEA-GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
Query: 224 LHMPNKYFEKQTFDEV 239
H N + E+++ V
Sbjct: 869 AH-GNSFNEEESESSV 883
Score = 68.5 bits (160), Expect = 2e-10
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 4/192 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G + L A GH V LL+ A+V+ D G + L AA G+ + + L++ A I
Sbjct: 744 GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI 803
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N A G+T L+LA NG +K L+ + V T TP+H A +G ++ KLL
Sbjct: 804 NHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Query: 1049 L--ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP-NLVMATTKDGNTCAHIAAI 1105
+ + A+ ++ +E + + P +L+ ++G T AHIAA
Sbjct: 863 MYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS 922
Query: 1106 QGSVKVIEELMK 1117
+G +E L +
Sbjct: 923 KGFKNCLEILCR 934
Score = 61.3 bits (142), Expect = 4e-08
Identities = 58/230 (25%), Positives = 105/230 (45%), Gaps = 30/230 (13%)
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
AAAQ N + ++ + L + + + +DG++ + AA G + L+ + ++A
Sbjct: 717 AAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--VNAA 773
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
+K N TPL AA GH + V +L+ A+ G T ++LA ++G+ + ++
Sbjct: 774 DK-NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTVKS-----------------EA 1229
T R G TP+H A G ++++ L+ H +P S E+
Sbjct: 833 GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEES 892
Query: 1230 PTGVSLVPVLGAE-------SGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
P G+S PV+ A+ G T H+AA G +N + +L G++ +
Sbjct: 893 PEGIS-KPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
Score = 56.8 bits (131), Expect = 8e-07
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 4/156 (2%)
Query: 997 TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID 1056
T L AA G L+ L+ + I+ + L+ AA +G + +LLL A ++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1057 ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
A D+ G P+ AAA + E V+L + N+ A G T ++A G+ + I+ L+
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-ADGGQTPLYLACKNGNKECIKLLL 830
Query: 1117 KFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+ G + + TP+ A + G+ D +++L+
Sbjct: 831 E---AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 56.0 bits (129), Expect = 1e-06
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 667 IHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+ AA G+V +++ LL ++G ++ + D ++AL+ A ++ V LL A V+
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA- 772
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
K TPL AA +C +L+ A N A + G TP+++A K GN + LLLE
Sbjct: 773 ADKNGFTPL-CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 786 DGGDPLRKT 794
G + KT
Sbjct: 832 AGTNRSVKT 840
Score = 47.2 bits (107), Expect = 6e-04
Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L E G D++ H +A + A G+ D + +++ +N + G+TPL
Sbjct: 730 LNEEGLDINYSCEDGH-SALYSAAKNGHTDCVRLLLS------AEAQVNAADKNGFTPLC 782
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
A +GH + V L++ A ++ G++ L+LA ++G + LL + K +
Sbjct: 783 AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD 842
Query: 995 GRTALHLAAMNGYAHLVKFLI 1015
G T +H A G +K L+
Sbjct: 843 GWTPVHAAVDTGNVDSLKLLM 863
Score = 44.4 bits (100), Expect = 0.004
Identities = 37/149 (24%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A + G+ I LL+ G + V T D +T +H AV++ ++ L+ +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA 869
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP---NKATEDGMTPVHVAAKFGNLAT 779
H + E+ + + G++ + K N A +G T H+AA G
Sbjct: 870 HGNSFNEEESESSV-FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNC 928
Query: 780 LVLLLEDGG-DPLRKTKV--CIYDVVTGE 805
L +L GG +P R+ K ++DV T +
Sbjct: 929 LEILCRHGGLEPERRDKCNRTVHDVATDD 957
Score = 35.1 bits (77), Expect = 2.7
Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 13/125 (10%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L+ AA+ D C +LL + A N A ++G TP+ AA G+ + LL+ +
Sbjct: 748 LYSAAKNGHTD-CVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN---- 802
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIE-----FVKDHKGESVSTAFIDAVDEDGA 848
+ G+TPL +AC++ + ++ L+E VK G + A +D + D
Sbjct: 803 ---INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL 859
Query: 849 SALHY 853
L Y
Sbjct: 860 KLLMY 864
>DQ388132-2|ABD72190.1| 1663|Homo sapiens CTTNBP2 protein.
Length = 1663
Score = 91.5 bits (217), Expect = 3e-17
Identities = 54/155 (34%), Positives = 85/155 (54%), Gaps = 2/155 (1%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
T L AA GN ++ +LLN G+ + S E+G++ L+ A GH V LLLS A++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINY-SCEDGHSALYSAAKNGHTDCVRLLLSAEAQV 770
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D++G T L A+ GH++ VE+L+ A IN G TPL+ A K G+ +KLL
Sbjct: 771 -NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
E+G + +T P+ A + D L+ L++
Sbjct: 830 LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY 864
Score = 87.8 bits (208), Expect = 4e-16
Identities = 68/223 (30%), Positives = 103/223 (46%), Gaps = 8/223 (3%)
Query: 966 LHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
L AA G + + LL + IN +G +AL+ AA NG+ V+ L+ A ++
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQVNA 772
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TPL AAA G E +LL+ ANI+ + GQ P++ A +N E ++L L+
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
N + TT DG T H A G+V ++ LM + R +S +GG
Sbjct: 833 GTNRSVKTT-DGWTPVHAAVDTGNVDSLKLLM-YHRIPAHGNSFNEEESESSVFDLDGGE 890
Query: 1145 AD---VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ + +V A NR G TA H+AA G N L+++
Sbjct: 891 ESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEIL 932
Score = 77.8 bits (183), Expect = 4e-13
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 21/270 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T LQ AA G+ ++ +L+ G G +A++ AA++GHT+ + ++ S
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPL AA G E V L+S+ + A+ G TPL+LA
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-------------ADGGQTPLYLAC 818
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
NGN+ ++LLL AG + + G+ P+H A G++ + LL+ ++
Sbjct: 819 KNGNKECIKLLLE-AGTNRSVKTTD-GWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE 876
Query: 1313 GKTGLHIASTHGHYQMVEVL---LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC-ES 1368
++ + G + E + + IN ++ GWT H AA G N +++LC
Sbjct: 877 EESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G P+ N + A+++ +LE L
Sbjct: 937 GLEPERRDKCN-RTVHDVATDDCKHLLENL 965
Score = 70.1 bits (164), Expect = 8e-11
Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 6/129 (4%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y DG ++++AA+ GH + LL V+ + +T L A VE L+
Sbjct: 739 YSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS 798
Query: 718 YGADV-HIRGGKQRETPLHIAARIPDGDK-CALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y A++ H G Q TPL++A + +G+K C +LL++G + T DG TPVH A G
Sbjct: 799 YDANINHAADGGQ--TPLYLACK--NGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
Query: 776 NLATLVLLL 784
N+ +L LL+
Sbjct: 855 NVDSLKLLM 863
Score = 68.5 bits (160), Expect = 2e-10
Identities = 57/196 (29%), Positives = 94/196 (47%), Gaps = 10/196 (5%)
Query: 51 WKKLIRDLVFQRGKVPL-----LL--AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH 103
W + L+ G PL LL A GN +++ LL+ + + + + G +AL+
Sbjct: 691 WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLD-INYSCEDGHSALY 749
Query: 104 LAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE 163
AA+ D R+L+ A V+A + G TPL AAA+G V+ AN A +
Sbjct: 750 SAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG 809
Query: 164 DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
+TP++LA +NG+ I+LL + + +T DG T +H A G+ D +L +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEA-GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
Query: 224 LHMPNKYFEKQTFDEV 239
H N + E+++ V
Sbjct: 869 AH-GNSFNEEESESSV 883
Score = 68.5 bits (160), Expect = 2e-10
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 4/192 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G + L A GH V LL+ A+V+ D G + L AA G+ + + L++ A I
Sbjct: 744 GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI 803
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N A G+T L+LA NG +K L+ + V T TP+H A +G ++ KLL
Sbjct: 804 NHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Query: 1049 L--ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP-NLVMATTKDGNTCAHIAAI 1105
+ + A+ ++ +E + + P +L+ ++G T AHIAA
Sbjct: 863 MYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS 922
Query: 1106 QGSVKVIEELMK 1117
+G +E L +
Sbjct: 923 KGFKNCLEILCR 934
Score = 61.3 bits (142), Expect = 4e-08
Identities = 58/230 (25%), Positives = 105/230 (45%), Gaps = 30/230 (13%)
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
AAAQ N + ++ + L + + + +DG++ + AA G + L+ + ++A
Sbjct: 717 AAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--VNAA 773
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
+K N TPL AA GH + V +L+ A+ G T ++LA ++G+ + ++
Sbjct: 774 DK-NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTVKS-----------------EA 1229
T R G TP+H A G ++++ L+ H +P S E+
Sbjct: 833 GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEES 892
Query: 1230 PTGVSLVPVLGAE-------SGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
P G+S PV+ A+ G T H+AA G +N + +L G++ +
Sbjct: 893 PEGIS-KPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
Score = 56.8 bits (131), Expect = 8e-07
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 4/156 (2%)
Query: 997 TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID 1056
T L AA G L+ L+ + I+ + L+ AA +G + +LLL A ++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1057 ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
A D+ G P+ AAA + E V+L + N+ A G T ++A G+ + I+ L+
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-ADGGQTPLYLACKNGNKECIKLLL 830
Query: 1117 KFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+ G + + TP+ A + G+ D +++L+
Sbjct: 831 E---AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 56.0 bits (129), Expect = 1e-06
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 667 IHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+ AA G+V +++ LL ++G ++ + D ++AL+ A ++ V LL A V+
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA- 772
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
K TPL AA +C +L+ A N A + G TP+++A K GN + LLLE
Sbjct: 773 ADKNGFTPL-CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 786 DGGDPLRKT 794
G + KT
Sbjct: 832 AGTNRSVKT 840
Score = 47.2 bits (107), Expect = 6e-04
Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L E G D++ H +A + A G+ D + +++ +N + G+TPL
Sbjct: 730 LNEEGLDINYSCEDGH-SALYSAAKNGHTDCVRLLLS------AEAQVNAADKNGFTPLC 782
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
A +GH + V L++ A ++ G++ L+LA ++G + LL + K +
Sbjct: 783 AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD 842
Query: 995 GRTALHLAAMNGYAHLVKFLI 1015
G T +H A G +K L+
Sbjct: 843 GWTPVHAAVDTGNVDSLKLLM 863
Score = 44.4 bits (100), Expect = 0.004
Identities = 37/149 (24%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A + G+ I LL+ G + V T D +T +H AV++ ++ L+ +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA 869
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP---NKATEDGMTPVHVAAKFGNLAT 779
H + E+ + + G++ + K N A +G T H+AA G
Sbjct: 870 HGNSFNEEESESSV-FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNC 928
Query: 780 LVLLLEDGG-DPLRKTKV--CIYDVVTGE 805
L +L GG +P R+ K ++DV T +
Sbjct: 929 LEILCRHGGLEPERRDKCNRTVHDVATDD 957
Score = 35.1 bits (77), Expect = 2.7
Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 13/125 (10%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L+ AA+ D C +LL + A N A ++G TP+ AA G+ + LL+ +
Sbjct: 748 LYSAAKNGHTD-CVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN---- 802
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIE-----FVKDHKGESVSTAFIDAVDEDGA 848
+ G+TPL +AC++ + ++ L+E VK G + A +D + D
Sbjct: 803 ---INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL 859
Query: 849 SALHY 853
L Y
Sbjct: 860 KLLMY 864
>DQ388131-2|ABD72188.1| 1663|Homo sapiens CTTNBP2 protein.
Length = 1663
Score = 91.5 bits (217), Expect = 3e-17
Identities = 54/155 (34%), Positives = 85/155 (54%), Gaps = 2/155 (1%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
T L AA GN ++ +LLN G+ + S E+G++ L+ A GH V LLLS A++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINY-SCEDGHSALYSAAKNGHTDCVRLLLSAEAQV 770
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D++G T L A+ GH++ VE+L+ A IN G TPL+ A K G+ +KLL
Sbjct: 771 -NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
E+G + +T P+ A + D L+ L++
Sbjct: 830 LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY 864
Score = 87.8 bits (208), Expect = 4e-16
Identities = 68/223 (30%), Positives = 103/223 (46%), Gaps = 8/223 (3%)
Query: 966 LHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
L AA G + + LL + IN +G +AL+ AA NG+ V+ L+ A ++
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQVNA 772
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TPL AAA G E +LL+ ANI+ + GQ P++ A +N E ++L L+
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
N + TT DG T H A G+V ++ LM + R +S +GG
Sbjct: 833 GTNRSVKTT-DGWTPVHAAVDTGNVDSLKLLM-YHRIPAHGNSFNEEESESSVFDLDGGE 890
Query: 1145 AD---VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ + +V A NR G TA H+AA G N L+++
Sbjct: 891 ESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEIL 932
Score = 77.8 bits (183), Expect = 4e-13
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 21/270 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T LQ AA G+ ++ +L+ G G +A++ AA++GHT+ + ++ S
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPL AA G E V L+S+ + A+ G TPL+LA
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-------------ADGGQTPLYLAC 818
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
NGN+ ++LLL AG + + G+ P+H A G++ + LL+ ++
Sbjct: 819 KNGNKECIKLLLE-AGTNRSVKTTD-GWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE 876
Query: 1313 GKTGLHIASTHGHYQMVEVL---LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC-ES 1368
++ + G + E + + IN ++ GWT H AA G N +++LC
Sbjct: 877 EESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G P+ N + A+++ +LE L
Sbjct: 937 GLEPERRDKCN-RTVHDVATDDCKHLLENL 965
Score = 70.1 bits (164), Expect = 8e-11
Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 6/129 (4%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y DG ++++AA+ GH + LL V+ + +T L A VE L+
Sbjct: 739 YSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS 798
Query: 718 YGADV-HIRGGKQRETPLHIAARIPDGDK-CALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y A++ H G Q TPL++A + +G+K C +LL++G + T DG TPVH A G
Sbjct: 799 YDANINHAADGGQ--TPLYLACK--NGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
Query: 776 NLATLVLLL 784
N+ +L LL+
Sbjct: 855 NVDSLKLLM 863
Score = 68.5 bits (160), Expect = 2e-10
Identities = 57/196 (29%), Positives = 94/196 (47%), Gaps = 10/196 (5%)
Query: 51 WKKLIRDLVFQRGKVPL-----LL--AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH 103
W + L+ G PL LL A GN +++ LL+ + + + + G +AL+
Sbjct: 691 WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLD-INYSCEDGHSALY 749
Query: 104 LAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE 163
AA+ D R+L+ A V+A + G TPL AAA+G V+ AN A +
Sbjct: 750 SAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG 809
Query: 164 DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
+TP++LA +NG+ I+LL + + +T DG T +H A G+ D +L +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEA-GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
Query: 224 LHMPNKYFEKQTFDEV 239
H N + E+++ V
Sbjct: 869 AH-GNSFNEEESESSV 883
Score = 68.5 bits (160), Expect = 2e-10
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 4/192 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G + L A GH V LL+ A+V+ D G + L AA G+ + + L++ A I
Sbjct: 744 GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI 803
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N A G+T L+LA NG +K L+ + V T TP+H A +G ++ KLL
Sbjct: 804 NHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Query: 1049 L--ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP-NLVMATTKDGNTCAHIAAI 1105
+ + A+ ++ +E + + P +L+ ++G T AHIAA
Sbjct: 863 MYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS 922
Query: 1106 QGSVKVIEELMK 1117
+G +E L +
Sbjct: 923 KGFKNCLEILCR 934
Score = 61.3 bits (142), Expect = 4e-08
Identities = 58/230 (25%), Positives = 105/230 (45%), Gaps = 30/230 (13%)
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
AAAQ N + ++ + L + + + +DG++ + AA G + L+ + ++A
Sbjct: 717 AAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--VNAA 773
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
+K N TPL AA GH + V +L+ A+ G T ++LA ++G+ + ++
Sbjct: 774 DK-NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTVKS-----------------EA 1229
T R G TP+H A G ++++ L+ H +P S E+
Sbjct: 833 GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEES 892
Query: 1230 PTGVSLVPVLGAE-------SGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
P G+S PV+ A+ G T H+AA G +N + +L G++ +
Sbjct: 893 PEGIS-KPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
Score = 56.8 bits (131), Expect = 8e-07
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 4/156 (2%)
Query: 997 TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID 1056
T L AA G L+ L+ + I+ + L+ AA +G + +LLL A ++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1057 ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
A D+ G P+ AAA + E V+L + N+ A G T ++A G+ + I+ L+
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-ADGGQTPLYLACKNGNKECIKLLL 830
Query: 1117 KFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+ G + + TP+ A + G+ D +++L+
Sbjct: 831 E---AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 56.0 bits (129), Expect = 1e-06
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 667 IHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+ AA G+V +++ LL ++G ++ + D ++AL+ A ++ V LL A V+
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA- 772
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
K TPL AA +C +L+ A N A + G TP+++A K GN + LLLE
Sbjct: 773 ADKNGFTPL-CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 786 DGGDPLRKT 794
G + KT
Sbjct: 832 AGTNRSVKT 840
Score = 47.2 bits (107), Expect = 6e-04
Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L E G D++ H +A + A G+ D + +++ +N + G+TPL
Sbjct: 730 LNEEGLDINYSCEDGH-SALYSAAKNGHTDCVRLLLS------AEAQVNAADKNGFTPLC 782
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
A +GH + V L++ A ++ G++ L+LA ++G + LL + K +
Sbjct: 783 AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD 842
Query: 995 GRTALHLAAMNGYAHLVKFLI 1015
G T +H A G +K L+
Sbjct: 843 GWTPVHAAVDTGNVDSLKLLM 863
Score = 44.4 bits (100), Expect = 0.004
Identities = 37/149 (24%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A + G+ I LL+ G + V T D +T +H AV++ ++ L+ +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA 869
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP---NKATEDGMTPVHVAAKFGNLAT 779
H + E+ + + G++ + K N A +G T H+AA G
Sbjct: 870 HGNSFNEEESESSV-FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNC 928
Query: 780 LVLLLEDGG-DPLRKTKV--CIYDVVTGE 805
L +L GG +P R+ K ++DV T +
Sbjct: 929 LEILCRHGGLEPERRDKCNRTVHDVATDD 957
Score = 35.1 bits (77), Expect = 2.7
Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 13/125 (10%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L+ AA+ D C +LL + A N A ++G TP+ AA G+ + LL+ +
Sbjct: 748 LYSAAKNGHTD-CVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN---- 802
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIE-----FVKDHKGESVSTAFIDAVDEDGA 848
+ G+TPL +AC++ + ++ L+E VK G + A +D + D
Sbjct: 803 ---INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL 859
Query: 849 SALHY 853
L Y
Sbjct: 860 KLLMY 864
>DQ388130-2|ABD72186.1| 1663|Homo sapiens CTTNBP2 protein.
Length = 1663
Score = 91.5 bits (217), Expect = 3e-17
Identities = 54/155 (34%), Positives = 85/155 (54%), Gaps = 2/155 (1%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
T L AA GN ++ +LLN G+ + S E+G++ L+ A GH V LLLS A++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINY-SCEDGHSALYSAAKNGHTDCVRLLLSAEAQV 770
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D++G T L A+ GH++ VE+L+ A IN G TPL+ A K G+ +KLL
Sbjct: 771 -NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
E+G + +T P+ A + D L+ L++
Sbjct: 830 LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY 864
Score = 87.8 bits (208), Expect = 4e-16
Identities = 68/223 (30%), Positives = 103/223 (46%), Gaps = 8/223 (3%)
Query: 966 LHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
L AA G + + LL + IN +G +AL+ AA NG+ V+ L+ A ++
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQVNA 772
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TPL AAA G E +LL+ ANI+ + GQ P++ A +N E ++L L+
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
N + TT DG T H A G+V ++ LM + R +S +GG
Sbjct: 833 GTNRSVKTT-DGWTPVHAAVDTGNVDSLKLLM-YHRIPAHGNSFNEEESESSVFDLDGGE 890
Query: 1145 AD---VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ + +V A NR G TA H+AA G N L+++
Sbjct: 891 ESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEIL 932
Score = 77.8 bits (183), Expect = 4e-13
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 21/270 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T LQ AA G+ ++ +L+ G G +A++ AA++GHT+ + ++ S
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPL AA G E V L+S+ + A+ G TPL+LA
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-------------ADGGQTPLYLAC 818
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
NGN+ ++LLL AG + + G+ P+H A G++ + LL+ ++
Sbjct: 819 KNGNKECIKLLLE-AGTNRSVKTTD-GWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE 876
Query: 1313 GKTGLHIASTHGHYQMVEVL---LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC-ES 1368
++ + G + E + + IN ++ GWT H AA G N +++LC
Sbjct: 877 EESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G P+ N + A+++ +LE L
Sbjct: 937 GLEPERRDKCN-RTVHDVATDDCKHLLENL 965
Score = 70.1 bits (164), Expect = 8e-11
Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 6/129 (4%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y DG ++++AA+ GH + LL V+ + +T L A VE L+
Sbjct: 739 YSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS 798
Query: 718 YGADV-HIRGGKQRETPLHIAARIPDGDK-CALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y A++ H G Q TPL++A + +G+K C +LL++G + T DG TPVH A G
Sbjct: 799 YDANINHAADGGQ--TPLYLACK--NGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
Query: 776 NLATLVLLL 784
N+ +L LL+
Sbjct: 855 NVDSLKLLM 863
Score = 68.5 bits (160), Expect = 2e-10
Identities = 57/196 (29%), Positives = 94/196 (47%), Gaps = 10/196 (5%)
Query: 51 WKKLIRDLVFQRGKVPL-----LL--AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH 103
W + L+ G PL LL A GN +++ LL+ + + + + G +AL+
Sbjct: 691 WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLD-INYSCEDGHSALY 749
Query: 104 LAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE 163
AA+ D R+L+ A V+A + G TPL AAA+G V+ AN A +
Sbjct: 750 SAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG 809
Query: 164 DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
+TP++LA +NG+ I+LL + + +T DG T +H A G+ D +L +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEA-GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
Query: 224 LHMPNKYFEKQTFDEV 239
H N + E+++ V
Sbjct: 869 AH-GNSFNEEESESSV 883
Score = 68.5 bits (160), Expect = 2e-10
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 4/192 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G + L A GH V LL+ A+V+ D G + L AA G+ + + L++ A I
Sbjct: 744 GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI 803
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N A G+T L+LA NG +K L+ + V T TP+H A +G ++ KLL
Sbjct: 804 NHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Query: 1049 L--ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP-NLVMATTKDGNTCAHIAAI 1105
+ + A+ ++ +E + + P +L+ ++G T AHIAA
Sbjct: 863 MYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS 922
Query: 1106 QGSVKVIEELMK 1117
+G +E L +
Sbjct: 923 KGFKNCLEILCR 934
Score = 61.3 bits (142), Expect = 4e-08
Identities = 58/230 (25%), Positives = 105/230 (45%), Gaps = 30/230 (13%)
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
AAAQ N + ++ + L + + + +DG++ + AA G + L+ + ++A
Sbjct: 717 AAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--VNAA 773
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
+K N TPL AA GH + V +L+ A+ G T ++LA ++G+ + ++
Sbjct: 774 DK-NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTVKS-----------------EA 1229
T R G TP+H A G ++++ L+ H +P S E+
Sbjct: 833 GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEES 892
Query: 1230 PTGVSLVPVLGAE-------SGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
P G+S PV+ A+ G T H+AA G +N + +L G++ +
Sbjct: 893 PEGIS-KPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
Score = 56.8 bits (131), Expect = 8e-07
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 4/156 (2%)
Query: 997 TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID 1056
T L AA G L+ L+ + I+ + L+ AA +G + +LLL A ++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1057 ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
A D+ G P+ AAA + E V+L + N+ A G T ++A G+ + I+ L+
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-ADGGQTPLYLACKNGNKECIKLLL 830
Query: 1117 KFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+ G + + TP+ A + G+ D +++L+
Sbjct: 831 E---AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 56.0 bits (129), Expect = 1e-06
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 667 IHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+ AA G+V +++ LL ++G ++ + D ++AL+ A ++ V LL A V+
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA- 772
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
K TPL AA +C +L+ A N A + G TP+++A K GN + LLLE
Sbjct: 773 ADKNGFTPL-CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 786 DGGDPLRKT 794
G + KT
Sbjct: 832 AGTNRSVKT 840
Score = 47.2 bits (107), Expect = 6e-04
Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L E G D++ H +A + A G+ D + +++ +N + G+TPL
Sbjct: 730 LNEEGLDINYSCEDGH-SALYSAAKNGHTDCVRLLLS------AEAQVNAADKNGFTPLC 782
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
A +GH + V L++ A ++ G++ L+LA ++G + LL + K +
Sbjct: 783 AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD 842
Query: 995 GRTALHLAAMNGYAHLVKFLI 1015
G T +H A G +K L+
Sbjct: 843 GWTPVHAAVDTGNVDSLKLLM 863
Score = 44.4 bits (100), Expect = 0.004
Identities = 37/149 (24%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A + G+ I LL+ G + V T D +T +H AV++ ++ L+ +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA 869
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP---NKATEDGMTPVHVAAKFGNLAT 779
H + E+ + + G++ + K N A +G T H+AA G
Sbjct: 870 HGNSFNEEESESSV-FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNC 928
Query: 780 LVLLLEDGG-DPLRKTKV--CIYDVVTGE 805
L +L GG +P R+ K ++DV T +
Sbjct: 929 LEILCRHGGLEPERRDKCNRTVHDVATDD 957
Score = 35.1 bits (77), Expect = 2.7
Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 13/125 (10%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L+ AA+ D C +LL + A N A ++G TP+ AA G+ + LL+ +
Sbjct: 748 LYSAAKNGHTD-CVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN---- 802
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIE-----FVKDHKGESVSTAFIDAVDEDGA 848
+ G+TPL +AC++ + ++ L+E VK G + A +D + D
Sbjct: 803 ---INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL 859
Query: 849 SALHY 853
L Y
Sbjct: 860 KLLMY 864
>DQ388129-2|ABD72184.1| 1663|Homo sapiens CTTNBP2 protein.
Length = 1663
Score = 91.5 bits (217), Expect = 3e-17
Identities = 54/155 (34%), Positives = 85/155 (54%), Gaps = 2/155 (1%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
T L AA GN ++ +LLN G+ + S E+G++ L+ A GH V LLLS A++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINY-SCEDGHSALYSAAKNGHTDCVRLLLSAEAQV 770
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D++G T L A+ GH++ VE+L+ A IN G TPL+ A K G+ +KLL
Sbjct: 771 -NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
E+G + +T P+ A + D L+ L++
Sbjct: 830 LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY 864
Score = 87.8 bits (208), Expect = 4e-16
Identities = 68/223 (30%), Positives = 103/223 (46%), Gaps = 8/223 (3%)
Query: 966 LHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
L AA G + + LL + IN +G +AL+ AA NG+ V+ L+ A ++
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQVNA 772
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TPL AAA G E +LL+ ANI+ + GQ P++ A +N E ++L L+
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
N + TT DG T H A G+V ++ LM + R +S +GG
Sbjct: 833 GTNRSVKTT-DGWTPVHAAVDTGNVDSLKLLM-YHRIPAHGNSFNEEESESSVFDLDGGE 890
Query: 1145 AD---VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ + +V A NR G TA H+AA G N L+++
Sbjct: 891 ESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEIL 932
Score = 77.8 bits (183), Expect = 4e-13
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 21/270 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T LQ AA G+ ++ +L+ G G +A++ AA++GHT+ + ++ S
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPL AA G E V L+S+ + A+ G TPL+LA
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-------------ADGGQTPLYLAC 818
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
NGN+ ++LLL AG + + G+ P+H A G++ + LL+ ++
Sbjct: 819 KNGNKECIKLLLE-AGTNRSVKTTD-GWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE 876
Query: 1313 GKTGLHIASTHGHYQMVEVL---LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC-ES 1368
++ + G + E + + IN ++ GWT H AA G N +++LC
Sbjct: 877 EESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G P+ N + A+++ +LE L
Sbjct: 937 GLEPERRDKCN-RTVHDVATDDCKHLLENL 965
Score = 70.1 bits (164), Expect = 8e-11
Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 6/129 (4%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y DG ++++AA+ GH + LL V+ + +T L A VE L+
Sbjct: 739 YSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS 798
Query: 718 YGADV-HIRGGKQRETPLHIAARIPDGDK-CALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y A++ H G Q TPL++A + +G+K C +LL++G + T DG TPVH A G
Sbjct: 799 YDANINHAADGGQ--TPLYLACK--NGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
Query: 776 NLATLVLLL 784
N+ +L LL+
Sbjct: 855 NVDSLKLLM 863
Score = 68.5 bits (160), Expect = 2e-10
Identities = 57/196 (29%), Positives = 94/196 (47%), Gaps = 10/196 (5%)
Query: 51 WKKLIRDLVFQRGKVPL-----LL--AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH 103
W + L+ G PL LL A GN +++ LL+ + + + + G +AL+
Sbjct: 691 WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLD-INYSCEDGHSALY 749
Query: 104 LAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE 163
AA+ D R+L+ A V+A + G TPL AAA+G V+ AN A +
Sbjct: 750 SAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG 809
Query: 164 DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
+TP++LA +NG+ I+LL + + +T DG T +H A G+ D +L +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEA-GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
Query: 224 LHMPNKYFEKQTFDEV 239
H N + E+++ V
Sbjct: 869 AH-GNSFNEEESESSV 883
Score = 68.5 bits (160), Expect = 2e-10
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 4/192 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G + L A GH V LL+ A+V+ D G + L AA G+ + + L++ A I
Sbjct: 744 GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI 803
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N A G+T L+LA NG +K L+ + V T TP+H A +G ++ KLL
Sbjct: 804 NHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Query: 1049 L--ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP-NLVMATTKDGNTCAHIAAI 1105
+ + A+ ++ +E + + P +L+ ++G T AHIAA
Sbjct: 863 MYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS 922
Query: 1106 QGSVKVIEELMK 1117
+G +E L +
Sbjct: 923 KGFKNCLEILCR 934
Score = 61.3 bits (142), Expect = 4e-08
Identities = 58/230 (25%), Positives = 105/230 (45%), Gaps = 30/230 (13%)
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
AAAQ N + ++ + L + + + +DG++ + AA G + L+ + ++A
Sbjct: 717 AAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--VNAA 773
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
+K N TPL AA GH + V +L+ A+ G T ++LA ++G+ + ++
Sbjct: 774 DK-NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTVKS-----------------EA 1229
T R G TP+H A G ++++ L+ H +P S E+
Sbjct: 833 GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEES 892
Query: 1230 PTGVSLVPVLGAE-------SGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
P G+S PV+ A+ G T H+AA G +N + +L G++ +
Sbjct: 893 PEGIS-KPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
Score = 56.8 bits (131), Expect = 8e-07
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 4/156 (2%)
Query: 997 TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID 1056
T L AA G L+ L+ + I+ + L+ AA +G + +LLL A ++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1057 ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
A D+ G P+ AAA + E V+L + N+ A G T ++A G+ + I+ L+
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-ADGGQTPLYLACKNGNKECIKLLL 830
Query: 1117 KFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+ G + + TP+ A + G+ D +++L+
Sbjct: 831 E---AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 56.0 bits (129), Expect = 1e-06
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 667 IHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+ AA G+V +++ LL ++G ++ + D ++AL+ A ++ V LL A V+
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA- 772
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
K TPL AA +C +L+ A N A + G TP+++A K GN + LLLE
Sbjct: 773 ADKNGFTPL-CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 786 DGGDPLRKT 794
G + KT
Sbjct: 832 AGTNRSVKT 840
Score = 47.2 bits (107), Expect = 6e-04
Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L E G D++ H +A + A G+ D + +++ +N + G+TPL
Sbjct: 730 LNEEGLDINYSCEDGH-SALYSAAKNGHTDCVRLLLS------AEAQVNAADKNGFTPLC 782
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
A +GH + V L++ A ++ G++ L+LA ++G + LL + K +
Sbjct: 783 AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD 842
Query: 995 GRTALHLAAMNGYAHLVKFLI 1015
G T +H A G +K L+
Sbjct: 843 GWTPVHAAVDTGNVDSLKLLM 863
Score = 44.4 bits (100), Expect = 0.004
Identities = 37/149 (24%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A + G+ I LL+ G + V T D +T +H AV++ ++ L+ +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA 869
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP---NKATEDGMTPVHVAAKFGNLAT 779
H + E+ + + G++ + K N A +G T H+AA G
Sbjct: 870 HGNSFNEEESESSV-FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNC 928
Query: 780 LVLLLEDGG-DPLRKTKV--CIYDVVTGE 805
L +L GG +P R+ K ++DV T +
Sbjct: 929 LEILCRHGGLEPERRDKCNRTVHDVATDD 957
Score = 35.1 bits (77), Expect = 2.7
Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 13/125 (10%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L+ AA+ D C +LL + A N A ++G TP+ AA G+ + LL+ +
Sbjct: 748 LYSAAKNGHTD-CVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN---- 802
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIE-----FVKDHKGESVSTAFIDAVDEDGA 848
+ G+TPL +AC++ + ++ L+E VK G + A +D + D
Sbjct: 803 ---INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL 859
Query: 849 SALHY 853
L Y
Sbjct: 860 KLLMY 864
>DQ388128-2|ABD72182.1| 1663|Homo sapiens CTTNBP2 protein.
Length = 1663
Score = 91.5 bits (217), Expect = 3e-17
Identities = 54/155 (34%), Positives = 85/155 (54%), Gaps = 2/155 (1%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
T L AA GN ++ +LLN G+ + S E+G++ L+ A GH V LLLS A++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINY-SCEDGHSALYSAAKNGHTDCVRLLLSAEAQV 770
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D++G T L A+ GH++ VE+L+ A IN G TPL+ A K G+ +KLL
Sbjct: 771 -NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
E+G + +T P+ A + D L+ L++
Sbjct: 830 LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY 864
Score = 87.8 bits (208), Expect = 4e-16
Identities = 68/223 (30%), Positives = 103/223 (46%), Gaps = 8/223 (3%)
Query: 966 LHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
L AA G + + LL + IN +G +AL+ AA NG+ V+ L+ A ++
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQVNA 772
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TPL AAA G E +LL+ ANI+ + GQ P++ A +N E ++L L+
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
N + TT DG T H A G+V ++ LM + R +S +GG
Sbjct: 833 GTNRSVKTT-DGWTPVHAAVDTGNVDSLKLLM-YHRIPAHGNSFNEEESESSVFDLDGGE 890
Query: 1145 AD---VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ + +V A NR G TA H+AA G N L+++
Sbjct: 891 ESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEIL 932
Score = 77.8 bits (183), Expect = 4e-13
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 21/270 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T LQ AA G+ ++ +L+ G G +A++ AA++GHT+ + ++ S
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPL AA G E V L+S+ + A+ G TPL+LA
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-------------ADGGQTPLYLAC 818
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
NGN+ ++LLL AG + + G+ P+H A G++ + LL+ ++
Sbjct: 819 KNGNKECIKLLLE-AGTNRSVKTTD-GWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE 876
Query: 1313 GKTGLHIASTHGHYQMVEVL---LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC-ES 1368
++ + G + E + + IN ++ GWT H AA G N +++LC
Sbjct: 877 EESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G P+ N + A+++ +LE L
Sbjct: 937 GLEPERRDKCN-RTVHDVATDDCKHLLENL 965
Score = 70.1 bits (164), Expect = 8e-11
Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 6/129 (4%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y DG ++++AA+ GH + LL V+ + +T L A VE L+
Sbjct: 739 YSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS 798
Query: 718 YGADV-HIRGGKQRETPLHIAARIPDGDK-CALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y A++ H G Q TPL++A + +G+K C +LL++G + T DG TPVH A G
Sbjct: 799 YDANINHAADGGQ--TPLYLACK--NGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
Query: 776 NLATLVLLL 784
N+ +L LL+
Sbjct: 855 NVDSLKLLM 863
Score = 68.5 bits (160), Expect = 2e-10
Identities = 57/196 (29%), Positives = 94/196 (47%), Gaps = 10/196 (5%)
Query: 51 WKKLIRDLVFQRGKVPL-----LL--AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH 103
W + L+ G PL LL A GN +++ LL+ + + + + G +AL+
Sbjct: 691 WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLD-INYSCEDGHSALY 749
Query: 104 LAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE 163
AA+ D R+L+ A V+A + G TPL AAA+G V+ AN A +
Sbjct: 750 SAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG 809
Query: 164 DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
+TP++LA +NG+ I+LL + + +T DG T +H A G+ D +L +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEA-GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
Query: 224 LHMPNKYFEKQTFDEV 239
H N + E+++ V
Sbjct: 869 AH-GNSFNEEESESSV 883
Score = 68.5 bits (160), Expect = 2e-10
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 4/192 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G + L A GH V LL+ A+V+ D G + L AA G+ + + L++ A I
Sbjct: 744 GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI 803
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N A G+T L+LA NG +K L+ + V T TP+H A +G ++ KLL
Sbjct: 804 NHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Query: 1049 L--ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP-NLVMATTKDGNTCAHIAAI 1105
+ + A+ ++ +E + + P +L+ ++G T AHIAA
Sbjct: 863 MYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS 922
Query: 1106 QGSVKVIEELMK 1117
+G +E L +
Sbjct: 923 KGFKNCLEILCR 934
Score = 61.3 bits (142), Expect = 4e-08
Identities = 58/230 (25%), Positives = 105/230 (45%), Gaps = 30/230 (13%)
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
AAAQ N + ++ + L + + + +DG++ + AA G + L+ + ++A
Sbjct: 717 AAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--VNAA 773
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
+K N TPL AA GH + V +L+ A+ G T ++LA ++G+ + ++
Sbjct: 774 DK-NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTVKS-----------------EA 1229
T R G TP+H A G ++++ L+ H +P S E+
Sbjct: 833 GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEES 892
Query: 1230 PTGVSLVPVLGAE-------SGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
P G+S PV+ A+ G T H+AA G +N + +L G++ +
Sbjct: 893 PEGIS-KPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
Score = 56.8 bits (131), Expect = 8e-07
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 4/156 (2%)
Query: 997 TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID 1056
T L AA G L+ L+ + I+ + L+ AA +G + +LLL A ++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1057 ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
A D+ G P+ AAA + E V+L + N+ A G T ++A G+ + I+ L+
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-ADGGQTPLYLACKNGNKECIKLLL 830
Query: 1117 KFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+ G + + TP+ A + G+ D +++L+
Sbjct: 831 E---AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 56.0 bits (129), Expect = 1e-06
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 667 IHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+ AA G+V +++ LL ++G ++ + D ++AL+ A ++ V LL A V+
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA- 772
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
K TPL AA +C +L+ A N A + G TP+++A K GN + LLLE
Sbjct: 773 ADKNGFTPL-CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 786 DGGDPLRKT 794
G + KT
Sbjct: 832 AGTNRSVKT 840
Score = 47.2 bits (107), Expect = 6e-04
Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L E G D++ H +A + A G+ D + +++ +N + G+TPL
Sbjct: 730 LNEEGLDINYSCEDGH-SALYSAAKNGHTDCVRLLLS------AEAQVNAADKNGFTPLC 782
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
A +GH + V L++ A ++ G++ L+LA ++G + LL + K +
Sbjct: 783 AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD 842
Query: 995 GRTALHLAAMNGYAHLVKFLI 1015
G T +H A G +K L+
Sbjct: 843 GWTPVHAAVDTGNVDSLKLLM 863
Score = 44.4 bits (100), Expect = 0.004
Identities = 37/149 (24%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A + G+ I LL+ G + V T D +T +H AV++ ++ L+ +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA 869
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP---NKATEDGMTPVHVAAKFGNLAT 779
H + E+ + + G++ + K N A +G T H+AA G
Sbjct: 870 HGNSFNEEESESSV-FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNC 928
Query: 780 LVLLLEDGG-DPLRKTKV--CIYDVVTGE 805
L +L GG +P R+ K ++DV T +
Sbjct: 929 LEILCRHGGLEPERRDKCNRTVHDVATDD 957
Score = 35.1 bits (77), Expect = 2.7
Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 13/125 (10%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L+ AA+ D C +LL + A N A ++G TP+ AA G+ + LL+ +
Sbjct: 748 LYSAAKNGHTD-CVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN---- 802
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIE-----FVKDHKGESVSTAFIDAVDEDGA 848
+ G+TPL +AC++ + ++ L+E VK G + A +D + D
Sbjct: 803 ---INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL 859
Query: 849 SALHY 853
L Y
Sbjct: 860 KLLMY 864
>DQ356264-2|ABC87066.1| 1663|Homo sapiens CTTNBP2 protein.
Length = 1663
Score = 91.5 bits (217), Expect = 3e-17
Identities = 54/155 (34%), Positives = 85/155 (54%), Gaps = 2/155 (1%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
T L AA GN ++ +LLN G+ + S E+G++ L+ A GH V LLLS A++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINY-SCEDGHSALYSAAKNGHTDCVRLLLSAEAQV 770
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D++G T L A+ GH++ VE+L+ A IN G TPL+ A K G+ +KLL
Sbjct: 771 -NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
E+G + +T P+ A + D L+ L++
Sbjct: 830 LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY 864
Score = 87.8 bits (208), Expect = 4e-16
Identities = 68/223 (30%), Positives = 103/223 (46%), Gaps = 8/223 (3%)
Query: 966 LHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
L AA G + + LL + IN +G +AL+ AA NG+ V+ L+ A ++
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQVNA 772
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TPL AAA G E +LL+ ANI+ + GQ P++ A +N E ++L L+
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
N + TT DG T H A G+V ++ LM + R +S +GG
Sbjct: 833 GTNRSVKTT-DGWTPVHAAVDTGNVDSLKLLM-YHRIPAHGNSFNEEESESSVFDLDGGE 890
Query: 1145 AD---VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ + +V A NR G TA H+AA G N L+++
Sbjct: 891 ESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEIL 932
Score = 77.8 bits (183), Expect = 4e-13
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 21/270 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T LQ AA G+ ++ +L+ G G +A++ AA++GHT+ + ++ S
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPL AA G E V L+S+ + A+ G TPL+LA
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-------------ADGGQTPLYLAC 818
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
NGN+ ++LLL AG + + G+ P+H A G++ + LL+ ++
Sbjct: 819 KNGNKECIKLLLE-AGTNRSVKTTD-GWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE 876
Query: 1313 GKTGLHIASTHGHYQMVEVL---LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC-ES 1368
++ + G + E + + IN ++ GWT H AA G N +++LC
Sbjct: 877 EESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G P+ N + A+++ +LE L
Sbjct: 937 GLEPERRDKCN-RTVHDVATDDCKHLLENL 965
Score = 70.1 bits (164), Expect = 8e-11
Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 6/129 (4%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y DG ++++AA+ GH + LL V+ + +T L A VE L+
Sbjct: 739 YSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS 798
Query: 718 YGADV-HIRGGKQRETPLHIAARIPDGDK-CALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y A++ H G Q TPL++A + +G+K C +LL++G + T DG TPVH A G
Sbjct: 799 YDANINHAADGGQ--TPLYLACK--NGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
Query: 776 NLATLVLLL 784
N+ +L LL+
Sbjct: 855 NVDSLKLLM 863
Score = 68.5 bits (160), Expect = 2e-10
Identities = 57/196 (29%), Positives = 94/196 (47%), Gaps = 10/196 (5%)
Query: 51 WKKLIRDLVFQRGKVPL-----LL--AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH 103
W + L+ G PL LL A GN +++ LL+ + + + + G +AL+
Sbjct: 691 WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLD-INYSCEDGHSALY 749
Query: 104 LAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE 163
AA+ D R+L+ A V+A + G TPL AAA+G V+ AN A +
Sbjct: 750 SAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG 809
Query: 164 DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
+TP++LA +NG+ I+LL + + +T DG T +H A G+ D +L +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEA-GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
Query: 224 LHMPNKYFEKQTFDEV 239
H N + E+++ V
Sbjct: 869 AH-GNSFNEEESESSV 883
Score = 68.5 bits (160), Expect = 2e-10
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 4/192 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G + L A GH V LL+ A+V+ D G + L AA G+ + + L++ A I
Sbjct: 744 GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI 803
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N A G+T L+LA NG +K L+ + V T TP+H A +G ++ KLL
Sbjct: 804 NHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Query: 1049 L--ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP-NLVMATTKDGNTCAHIAAI 1105
+ + A+ ++ +E + + P +L+ ++G T AHIAA
Sbjct: 863 MYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS 922
Query: 1106 QGSVKVIEELMK 1117
+G +E L +
Sbjct: 923 KGFKNCLEILCR 934
Score = 61.3 bits (142), Expect = 4e-08
Identities = 58/230 (25%), Positives = 105/230 (45%), Gaps = 30/230 (13%)
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
AAAQ N + ++ + L + + + +DG++ + AA G + L+ + ++A
Sbjct: 717 AAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--VNAA 773
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
+K N TPL AA GH + V +L+ A+ G T ++LA ++G+ + ++
Sbjct: 774 DK-NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTVKS-----------------EA 1229
T R G TP+H A G ++++ L+ H +P S E+
Sbjct: 833 GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEES 892
Query: 1230 PTGVSLVPVLGAE-------SGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
P G+S PV+ A+ G T H+AA G +N + +L G++ +
Sbjct: 893 PEGIS-KPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
Score = 56.8 bits (131), Expect = 8e-07
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 4/156 (2%)
Query: 997 TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID 1056
T L AA G L+ L+ + I+ + L+ AA +G + +LLL A ++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1057 ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
A D+ G P+ AAA + E V+L + N+ A G T ++A G+ + I+ L+
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-ADGGQTPLYLACKNGNKECIKLLL 830
Query: 1117 KFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+ G + + TP+ A + G+ D +++L+
Sbjct: 831 E---AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 56.0 bits (129), Expect = 1e-06
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 667 IHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+ AA G+V +++ LL ++G ++ + D ++AL+ A ++ V LL A V+
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA- 772
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
K TPL AA +C +L+ A N A + G TP+++A K GN + LLLE
Sbjct: 773 ADKNGFTPL-CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 786 DGGDPLRKT 794
G + KT
Sbjct: 832 AGTNRSVKT 840
Score = 47.2 bits (107), Expect = 6e-04
Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L E G D++ H +A + A G+ D + +++ +N + G+TPL
Sbjct: 730 LNEEGLDINYSCEDGH-SALYSAAKNGHTDCVRLLLS------AEAQVNAADKNGFTPLC 782
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
A +GH + V L++ A ++ G++ L+LA ++G + LL + K +
Sbjct: 783 AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD 842
Query: 995 GRTALHLAAMNGYAHLVKFLI 1015
G T +H A G +K L+
Sbjct: 843 GWTPVHAAVDTGNVDSLKLLM 863
Score = 44.4 bits (100), Expect = 0.004
Identities = 37/149 (24%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A + G+ I LL+ G + V T D +T +H AV++ ++ L+ +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA 869
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP---NKATEDGMTPVHVAAKFGNLAT 779
H + E+ + + G++ + K N A +G T H+AA G
Sbjct: 870 HGNSFNEEESESSV-FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNC 928
Query: 780 LVLLLEDGG-DPLRKTKV--CIYDVVTGE 805
L +L GG +P R+ K ++DV T +
Sbjct: 929 LEILCRHGGLEPERRDKCNRTVHDVATDD 957
Score = 35.1 bits (77), Expect = 2.7
Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 13/125 (10%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L+ AA+ D C +LL + A N A ++G TP+ AA G+ + LL+ +
Sbjct: 748 LYSAAKNGHTD-CVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN---- 802
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIE-----FVKDHKGESVSTAFIDAVDEDGA 848
+ G+TPL +AC++ + ++ L+E VK G + A +D + D
Sbjct: 803 ---INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL 859
Query: 849 SALHY 853
L Y
Sbjct: 860 KLLMY 864
>DQ356263-2|ABC87064.1| 1663|Homo sapiens CTTNBP2 protein.
Length = 1663
Score = 91.5 bits (217), Expect = 3e-17
Identities = 54/155 (34%), Positives = 85/155 (54%), Gaps = 2/155 (1%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
T L AA GN ++ +LLN G+ + S E+G++ L+ A GH V LLLS A++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINY-SCEDGHSALYSAAKNGHTDCVRLLLSAEAQV 770
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D++G T L A+ GH++ VE+L+ A IN G TPL+ A K G+ +KLL
Sbjct: 771 -NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
E+G + +T P+ A + D L+ L++
Sbjct: 830 LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY 864
Score = 87.8 bits (208), Expect = 4e-16
Identities = 68/223 (30%), Positives = 103/223 (46%), Gaps = 8/223 (3%)
Query: 966 LHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
L AA G + + LL + IN +G +AL+ AA NG+ V+ L+ A ++
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQVNA 772
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TPL AAA G E +LL+ ANI+ + GQ P++ A +N E ++L L+
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
N + TT DG T H A G+V ++ LM + R +S +GG
Sbjct: 833 GTNRSVKTT-DGWTPVHAAVDTGNVDSLKLLM-YHRIPAHGNSFNEEESESSVFDLDGGE 890
Query: 1145 AD---VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ + +V A NR G TA H+AA G N L+++
Sbjct: 891 ESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEIL 932
Score = 77.8 bits (183), Expect = 4e-13
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 21/270 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T LQ AA G+ ++ +L+ G G +A++ AA++GHT+ + ++ S
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPL AA G E V L+S+ + A+ G TPL+LA
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-------------ADGGQTPLYLAC 818
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
NGN+ ++LLL AG + + G+ P+H A G++ + LL+ ++
Sbjct: 819 KNGNKECIKLLLE-AGTNRSVKTTD-GWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE 876
Query: 1313 GKTGLHIASTHGHYQMVEVL---LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC-ES 1368
++ + G + E + + IN ++ GWT H AA G N +++LC
Sbjct: 877 EESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G P+ N + A+++ +LE L
Sbjct: 937 GLEPERRDKCN-RTVHDVATDDCKHLLENL 965
Score = 70.1 bits (164), Expect = 8e-11
Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 6/129 (4%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y DG ++++AA+ GH + LL V+ + +T L A VE L+
Sbjct: 739 YSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS 798
Query: 718 YGADV-HIRGGKQRETPLHIAARIPDGDK-CALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y A++ H G Q TPL++A + +G+K C +LL++G + T DG TPVH A G
Sbjct: 799 YDANINHAADGGQ--TPLYLACK--NGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
Query: 776 NLATLVLLL 784
N+ +L LL+
Sbjct: 855 NVDSLKLLM 863
Score = 68.5 bits (160), Expect = 2e-10
Identities = 57/196 (29%), Positives = 94/196 (47%), Gaps = 10/196 (5%)
Query: 51 WKKLIRDLVFQRGKVPL-----LL--AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH 103
W + L+ G PL LL A GN +++ LL+ + + + + G +AL+
Sbjct: 691 WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLD-INYSCEDGHSALY 749
Query: 104 LAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE 163
AA+ D R+L+ A V+A + G TPL AAA+G V+ AN A +
Sbjct: 750 SAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG 809
Query: 164 DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
+TP++LA +NG+ I+LL + + +T DG T +H A G+ D +L +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEA-GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
Query: 224 LHMPNKYFEKQTFDEV 239
H N + E+++ V
Sbjct: 869 AH-GNSFNEEESESSV 883
Score = 68.5 bits (160), Expect = 2e-10
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 4/192 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G + L A GH V LL+ A+V+ D G + L AA G+ + + L++ A I
Sbjct: 744 GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI 803
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N A G+T L+LA NG +K L+ + V T TP+H A +G ++ KLL
Sbjct: 804 NHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Query: 1049 L--ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP-NLVMATTKDGNTCAHIAAI 1105
+ + A+ ++ +E + + P +L+ ++G T AHIAA
Sbjct: 863 MYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS 922
Query: 1106 QGSVKVIEELMK 1117
+G +E L +
Sbjct: 923 KGFKNCLEILCR 934
Score = 61.3 bits (142), Expect = 4e-08
Identities = 58/230 (25%), Positives = 105/230 (45%), Gaps = 30/230 (13%)
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
AAAQ N + ++ + L + + + +DG++ + AA G + L+ + ++A
Sbjct: 717 AAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--VNAA 773
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
+K N TPL AA GH + V +L+ A+ G T ++LA ++G+ + ++
Sbjct: 774 DK-NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTVKS-----------------EA 1229
T R G TP+H A G ++++ L+ H +P S E+
Sbjct: 833 GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEES 892
Query: 1230 PTGVSLVPVLGAE-------SGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
P G+S PV+ A+ G T H+AA G +N + +L G++ +
Sbjct: 893 PEGIS-KPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
Score = 56.8 bits (131), Expect = 8e-07
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 4/156 (2%)
Query: 997 TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID 1056
T L AA G L+ L+ + I+ + L+ AA +G + +LLL A ++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1057 ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
A D+ G P+ AAA + E V+L + N+ A G T ++A G+ + I+ L+
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-ADGGQTPLYLACKNGNKECIKLLL 830
Query: 1117 KFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+ G + + TP+ A + G+ D +++L+
Sbjct: 831 E---AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 56.0 bits (129), Expect = 1e-06
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 667 IHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+ AA G+V +++ LL ++G ++ + D ++AL+ A ++ V LL A V+
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA- 772
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
K TPL AA +C +L+ A N A + G TP+++A K GN + LLLE
Sbjct: 773 ADKNGFTPL-CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 786 DGGDPLRKT 794
G + KT
Sbjct: 832 AGTNRSVKT 840
Score = 47.2 bits (107), Expect = 6e-04
Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L E G D++ H +A + A G+ D + +++ +N + G+TPL
Sbjct: 730 LNEEGLDINYSCEDGH-SALYSAAKNGHTDCVRLLLS------AEAQVNAADKNGFTPLC 782
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
A +GH + V L++ A ++ G++ L+LA ++G + LL + K +
Sbjct: 783 AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD 842
Query: 995 GRTALHLAAMNGYAHLVKFLI 1015
G T +H A G +K L+
Sbjct: 843 GWTPVHAAVDTGNVDSLKLLM 863
Score = 44.4 bits (100), Expect = 0.004
Identities = 37/149 (24%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A + G+ I LL+ G + V T D +T +H AV++ ++ L+ +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA 869
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP---NKATEDGMTPVHVAAKFGNLAT 779
H + E+ + + G++ + K N A +G T H+AA G
Sbjct: 870 HGNSFNEEESESSV-FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNC 928
Query: 780 LVLLLEDGG-DPLRKTKV--CIYDVVTGE 805
L +L GG +P R+ K ++DV T +
Sbjct: 929 LEILCRHGGLEPERRDKCNRTVHDVATDD 957
Score = 35.1 bits (77), Expect = 2.7
Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 13/125 (10%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L+ AA+ D C +LL + A N A ++G TP+ AA G+ + LL+ +
Sbjct: 748 LYSAAKNGHTD-CVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN---- 802
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIE-----FVKDHKGESVSTAFIDAVDEDGA 848
+ G+TPL +AC++ + ++ L+E VK G + A +D + D
Sbjct: 803 ---INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL 859
Query: 849 SALHY 853
L Y
Sbjct: 860 KLLMY 864
>DQ356262-2|ABC87062.1| 1663|Homo sapiens CTTNBP2 protein.
Length = 1663
Score = 91.5 bits (217), Expect = 3e-17
Identities = 54/155 (34%), Positives = 85/155 (54%), Gaps = 2/155 (1%)
Query: 1246 TPLHLAAYNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAEL 1305
T L AA GN ++ +LLN G+ + S E+G++ L+ A GH V LLLS A++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINY-SCEDGHSALYSAAKNGHTDCVRLLLSAEAQV 770
Query: 1306 LHSTDRHGKTGLHIASTHGHYQMVEVLLGQGAEINATDKNGWTPLHCAAKAGHLNVVKLL 1365
++ D++G T L A+ GH++ VE+L+ A IN G TPL+ A K G+ +KLL
Sbjct: 771 -NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL 829
Query: 1366 CESGASPKSETNLNCAPIWFAASENHNDVLEYLLH 1400
E+G + +T P+ A + D L+ L++
Sbjct: 830 LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY 864
Score = 87.8 bits (208), Expect = 4e-16
Identities = 68/223 (30%), Positives = 103/223 (46%), Gaps = 8/223 (3%)
Query: 966 LHLAAEHGYLQVCDALLTNKAF-INSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDV 1024
L AA G + + LL + IN +G +AL+ AA NG+ V+ L+ A ++
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQVNA 772
Query: 1025 LTLKKQTPLHLAAASGQIEVCKLLLELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQ 1084
TPL AAA G E +LL+ ANI+ + GQ P++ A +N E ++L L+
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1085 HPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGH 1144
N + TT DG T H A G+V ++ LM + R +S +GG
Sbjct: 833 GTNRSVKTT-DGWTPVHAAVDTGNVDSLKLLM-YHRIPAHGNSFNEEESESSVFDLDGGE 890
Query: 1145 AD---VVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVM 1184
+ + +V A NR G TA H+AA G N L+++
Sbjct: 891 ESPEGISKPVVPADL-INHANREGWTAAHIAASKGFKNCLEIL 932
Score = 77.8 bits (183), Expect = 4e-13
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 21/270 (7%)
Query: 1134 TPLQLAAEGGHADVVRVLVRA-GASCTDENRAGLTAVHLAAEHGHTNVLDVMRSTNTLRI 1192
T LQ AA G+ ++ +L+ G G +A++ AA++GHT+ + ++ S
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1193 SSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPTGVSLVPVLGAESGLTPLHLAA 1252
++ K G TPL AA G E V L+S+ + A+ G TPL+LA
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-------------ADGGQTPLYLAC 818
Query: 1253 YNGNENVVRLLLNSAGVQADAASNENGYNPLHLACFGGHMSIVGLLLSRSAELLHSTDRH 1312
NGN+ ++LLL AG + + G+ P+H A G++ + LL+ ++
Sbjct: 819 KNGNKECIKLLLE-AGTNRSVKTTD-GWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNE 876
Query: 1313 GKTGLHIASTHGHYQMVEVL---LGQGAEINATDKNGWTPLHCAAKAGHLNVVKLLC-ES 1368
++ + G + E + + IN ++ GWT H AA G N +++LC
Sbjct: 877 EESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHG 936
Query: 1369 GASPKSETNLNCAPIWFAASENHNDVLEYL 1398
G P+ N + A+++ +LE L
Sbjct: 937 GLEPERRDKCN-RTVHDVATDDCKHLLENL 965
Score = 70.1 bits (164), Expect = 8e-11
Identities = 44/129 (34%), Positives = 68/129 (52%), Gaps = 6/129 (4%)
Query: 658 YKHFDGARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLG 717
Y DG ++++AA+ GH + LL V+ + +T L A VE L+
Sbjct: 739 YSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS 798
Query: 718 YGADV-HIRGGKQRETPLHIAARIPDGDK-CALMLLKSGAGPNKATEDGMTPVHVAAKFG 775
Y A++ H G Q TPL++A + +G+K C +LL++G + T DG TPVH A G
Sbjct: 799 YDANINHAADGGQ--TPLYLACK--NGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
Query: 776 NLATLVLLL 784
N+ +L LL+
Sbjct: 855 NVDSLKLLM 863
Score = 68.5 bits (160), Expect = 2e-10
Identities = 57/196 (29%), Positives = 94/196 (47%), Gaps = 10/196 (5%)
Query: 51 WKKLIRDLVFQRGKVPL-----LL--AVEAGNQSMVRELLSAQTAEQLKATTPAGDTALH 103
W + L+ G PL LL A GN +++ LL+ + + + + G +AL+
Sbjct: 691 WSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLD-INYSCEDGHSALY 749
Query: 104 LAARRRDVDMARILVDYGAVVDATNGAGQTPLHIAAAEGDEPLVKYFYGVRANAAIADNE 163
AA+ D R+L+ A V+A + G TPL AAA+G V+ AN A +
Sbjct: 750 SAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG 809
Query: 164 DRTPMHLAAENGHAAIIELLADKFKASIFERTKDGSTLMHIASLNGHADCAMMLFKKGVY 223
+TP++LA +NG+ I+LL + + +T DG T +H A G+ D +L +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEA-GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP 868
Query: 224 LHMPNKYFEKQTFDEV 239
H N + E+++ V
Sbjct: 869 AH-GNSFNEEESESSV 883
Score = 68.5 bits (160), Expect = 2e-10
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 4/192 (2%)
Query: 929 GWTPLLIACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFI 988
G + L A GH V LL+ A+V+ D G + L AA G+ + + L++ A I
Sbjct: 744 GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI 803
Query: 989 NSKARNGRTALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLL 1048
N A G+T L+LA NG +K L+ + V T TP+H A +G ++ KLL
Sbjct: 804 NHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Query: 1049 L--ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQQHP-NLVMATTKDGNTCAHIAAI 1105
+ + A+ ++ +E + + P +L+ ++G T AHIAA
Sbjct: 863 MYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS 922
Query: 1106 QGSVKVIEELMK 1117
+G +E L +
Sbjct: 923 KGFKNCLEILCR 934
Score = 61.3 bits (142), Expect = 4e-08
Identities = 58/230 (25%), Positives = 105/230 (45%), Gaps = 30/230 (13%)
Query: 1068 AAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELMKFDRTGVISAR 1127
AAAQ N + ++ + L + + + +DG++ + AA G + L+ + ++A
Sbjct: 717 AAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--VNAA 773
Query: 1128 NKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLAAEHGHTNVLDVMRST 1187
+K N TPL AA GH + V +L+ A+ G T ++LA ++G+ + ++
Sbjct: 774 DK-NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA 832
Query: 1188 NTLRISSKKLGLTPLHIAAYYGQAETVRELLSH-VPGTVKS-----------------EA 1229
T R G TP+H A G ++++ L+ H +P S E+
Sbjct: 833 GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEES 892
Query: 1230 PTGVSLVPVLGAE-------SGLTPLHLAAYNGNENVVRLLLNSAGVQAD 1272
P G+S PV+ A+ G T H+AA G +N + +L G++ +
Sbjct: 893 PEGIS-KPVVPADLINHANREGWTAAHIAASKGFKNCLEILCRHGGLEPE 941
Score = 56.8 bits (131), Expect = 8e-07
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 4/156 (2%)
Query: 997 TALHLAAMNGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASGQIEVCKLLLELGANID 1056
T L AA G L+ L+ + I+ + L+ AA +G + +LLL A ++
Sbjct: 712 TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN 771
Query: 1057 ATDELGQKPIHAAAQNNYSEVVQLFLQQHPNLVMATTKDGNTCAHIAAIQGSVKVIEELM 1116
A D+ G P+ AAA + E V+L + N+ A G T ++A G+ + I+ L+
Sbjct: 772 AADKNGFTPLCAAAAQGHFECVELLISYDANINHA-ADGGQTPLYLACKNGNKECIKLLL 830
Query: 1117 KFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLV 1152
+ G + + TP+ A + G+ D +++L+
Sbjct: 831 E---AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 56.0 bits (129), Expect = 1e-06
Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 667 IHTAARYGHVGIINTLL-QKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADVHIR 725
+ AA G+V +++ LL ++G ++ + D ++AL+ A ++ V LL A V+
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA- 772
Query: 726 GGKQRETPLHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLE 785
K TPL AA +C +L+ A N A + G TP+++A K GN + LLLE
Sbjct: 773 ADKNGFTPL-CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE 831
Query: 786 DGGDPLRKT 794
G + KT
Sbjct: 832 AGTNRSVKT 840
Score = 47.2 bits (107), Expect = 6e-04
Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 7/141 (4%)
Query: 875 LIENGADVSLQTRHNHETAFHYCAIAGNNDVMTEMIAHISTADVSRALNRQNSIGWTPLL 934
L E G D++ H +A + A G+ D + +++ +N + G+TPL
Sbjct: 730 LNEEGLDINYSCEDGH-SALYSAAKNGHTDCVRLLLS------AEAQVNAADKNGFTPLC 782
Query: 935 IACHRGHMQLVNTLLTNHARVDVFDVEGRSALHLAAEHGYLQVCDALLTNKAFINSKARN 994
A +GH + V L++ A ++ G++ L+LA ++G + LL + K +
Sbjct: 783 AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD 842
Query: 995 GRTALHLAAMNGYAHLVKFLI 1015
G T +H A G +K L+
Sbjct: 843 GWTPVHAAVDTGNVDSLKLLM 863
Score = 44.4 bits (100), Expect = 0.004
Identities = 37/149 (24%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 663 GARSIHTAARYGHVGIINTLLQKGESVDVTTNDNYTALHIAVESCKPAVVETLLGYGADV 722
G ++ A + G+ I LL+ G + V T D +T +H AV++ ++ L+ +
Sbjct: 810 GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA 869
Query: 723 HIRGGKQRETPLHIAARIPDGDKCALMLLKSGAGP---NKATEDGMTPVHVAAKFGNLAT 779
H + E+ + + G++ + K N A +G T H+AA G
Sbjct: 870 HGNSFNEEESESSV-FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNC 928
Query: 780 LVLLLEDGG-DPLRKTKV--CIYDVVTGE 805
L +L GG +P R+ K ++DV T +
Sbjct: 929 LEILCRHGGLEPERRDKCNRTVHDVATDD 957
Score = 35.1 bits (77), Expect = 2.7
Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 13/125 (10%)
Query: 734 LHIAARIPDGDKCALMLLKSGAGPNKATEDGMTPVHVAAKFGNLATLVLLLEDGGDPLRK 793
L+ AA+ D C +LL + A N A ++G TP+ AA G+ + LL+ +
Sbjct: 748 LYSAAKNGHTD-CVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN---- 802
Query: 794 TKVCIYDVVTGETPLQMACRSCMPDIVRHLIE-----FVKDHKGESVSTAFIDAVDEDGA 848
+ G+TPL +AC++ + ++ L+E VK G + A +D + D
Sbjct: 803 ---INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL 859
Query: 849 SALHY 853
L Y
Sbjct: 860 KLLMY 864
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.321 0.136 0.405
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 296,302,898
Number of Sequences: 224733
Number of extensions: 12470127
Number of successful extensions: 74577
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 1143
Number of HSP's successfully gapped in prelim test: 171
Number of HSP's that attempted gapping in prelim test: 28259
Number of HSP's gapped (non-prelim): 19433
length of query: 2086
length of database: 73,234,838
effective HSP length: 101
effective length of query: 1985
effective length of database: 50,536,805
effective search space: 100315557925
effective search space used: 100315557925
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 73 (33.5 bits)
- SilkBase 1999-2023 -