Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA005142-TA|BGIBMGA005142-PA|IPR000602|Glycoside
hydrolase, family 38, IPR011682|Glycosyl hydrolases 38, C-terminal,
IPR011013|Galactose mutarotase-like
(1027 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
D63998-1|BAA10017.1| 1143|Homo sapiens golgi alpha-mannosidaseII... 748 0.0
U31520-1|AAC50302.1| 1144|Homo sapiens alpha mannosidase II prot... 744 0.0
D55649-1|BAA09510.1| 1139|Homo sapiens alpha mannosidase II isoz... 638 0.0
L28821-1|AAA92022.1| 796|Homo sapiens alpha mannosidase II isoz... 620 e-177
BC094773-1|AAH94773.1| 1009|Homo sapiens mannosidase, alpha, cla... 219 3e-56
BC033307-1|AAH33307.1| 1009|Homo sapiens mannosidase, alpha, cla... 219 3e-56
AB023152-1|BAA76779.2| 952|Homo sapiens KIAA0935 protein protein. 219 3e-56
AL833071-1|CAD89971.1| 1009|Homo sapiens hypothetical protein pr... 215 7e-55
U68567-1|AAC50812.1| 988|Homo sapiens lysosomal acid alpha-mann... 198 8e-50
U60266-1|AAC34130.1| 1011|Homo sapiens lysosomal alpha-mannosida... 198 1e-49
AB209921-1|BAD93158.1| 1007|Homo sapiens mannosidase, alpha, cla... 197 2e-49
U60899-1|AAC51362.1| 1010|Homo sapiens lysosomal alpha-mannosida... 195 8e-49
BC000736-1|AAH00736.1| 1011|Homo sapiens mannosidase, alpha, cla... 195 8e-49
U05572-1|AAB03816.1| 987|Homo sapiens alpha-mannosidase protein. 193 3e-48
U68382-1|AAC50811.1| 323|Homo sapiens truncated lysosomal acid ... 147 2e-34
BC036836-1|AAH36836.1| 358|Homo sapiens MAN2B2 protein protein. 60 4e-08
BC080191-1|AAH80191.1| 1017|Homo sapiens MAN2C1 protein protein. 41 0.026
BC050550-1|AAH50550.1| 1040|Homo sapiens mannosidase, alpha, cla... 41 0.026
AF044414-1|AAC00190.2| 1062|Homo sapiens alpha mannosidase 6A8B ... 41 0.026
BX640905-1|CAE45950.1| 1706|Homo sapiens hypothetical protein pr... 35 1.7
AY137776-1|AAN11306.1| 1706|Homo sapiens DNA strand-exchange pro... 35 1.7
AL133623-1|CAB63749.1| 1159|Homo sapiens hypothetical protein pr... 35 1.7
>D63998-1|BAA10017.1| 1143|Homo sapiens golgi alpha-mannosidaseII
protein.
Length = 1143
Score = 748 bits (1849), Expect = 0.0
Identities = 410/997 (41%), Positives = 591/997 (59%), Gaps = 39/997 (3%)
Query: 1 QMLSLYERIMFDDKDGGVWKQGWNIEYNENQWSQKNKLKVFIVPHSHNDPGWLKTFENYY 60
QML +Y I FD+ DGGVWKQG++I Y N+W + L+VF+VPHSHNDPGWLKTF +Y+
Sbjct: 130 QMLDVYSLISFDNPDGGVWKQGFDITYESNEWDTE-PLQVFVVPHSHNDPGWLKTFNDYF 188
Query: 61 KSQTRAIFNNMIEKLNEGVGRKFIWAEISFLSLWWNNDATEKDKTAFLNLLKSKKLEIVT 120
+ +T+ IFNNM+ KL E RKFIW+EIS+LS WW+ +K K A +L+++ +LEIVT
Sbjct: 189 RDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQK-KDAVKSLIENGQLEIVT 247
Query: 121 GGWVMNDEANSHWLSVVQQLTTGHQWLLDNLGYVPKNAWSIDPFGYSSAQPYLLKIAGFD 180
GGWVM DEA H+ +++ QL GHQWL +N+G P++ W+IDPFG+S YLL AG
Sbjct: 248 GGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYLLNRAGLS 307
Query: 181 NSMIQRVHYRIKKELASNRQLEFRWRQLWDGVGKTDMFTHLFPFYSYDVPHSCGPDPKIC 240
+ +IQRVHY +KK A ++ LEF WRQ WD TD+ H+ PFYSYD+PH+CGPDPKIC
Sbjct: 308 HMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTCGPDPKIC 367
Query: 241 CQFDFKRLPGNGVTCPWGVAPQRITQKNVDERAFKILDQWRKKAQLYRSNVLFFPLGDDF 300
CQFDFKRLPG CPWGV P+ I NV RA +LDQ+RKK++L+R+ VL PLGDDF
Sbjct: 368 CQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLLAPLGDDF 427
Query: 301 RYDHANEWDNQYQNYDMLIEYINSNDAWNTEVQYGTLEDYFKALH--DEVK----LSNFP 354
RY EWD Q++NY L +Y+NS + ++Q+GTL D+F AL DE + S FP
Sbjct: 428 RYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRDKGQSMFP 487
Query: 355 VLSGDFFTYADRNQHYWSGYYTSRPFYKNMDRVLLAYVRAAEII---TAQATDTHAVSYI 411
VLSGDFFTYADR+ HYWSGY+TSRPFYK MDR++ +++RAAEI+ + + ++
Sbjct: 488 VLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAHKYKINKF 547
Query: 412 MSLQLRDRVEQARRSLSLFQHHDGITGTSRDEVREDYAKKMLTAIKYSQSAIQQAAYYL- 470
+S L + +ARR+L LFQHHD ITGT++D V DY ++ ++ + I +A+ L
Sbjct: 548 LSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIGNSAFLLI 607
Query: 471 LKQPHIQDQTQEDIFLDVDDIWRRHDEIPSRITIALDVVSPSRRLVLYNALAFRRQEILT 530
LK D D FL++D + D +P + I L + R LV+YN L R +++
Sbjct: 608 LKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLS--AEPRYLVVYNPLEQDRISLVS 665
Query: 531 VLVSTPHVEVFDPEGEPIMAQVSPVVAGERRLGLANNKYQLSFPVTIGPLALTVYSVSLR 590
V VS+P V+VF G+P+ QVS V + ++ Y++SF I PL L VY +
Sbjct: 666 VYVSSPTVQVFSASGKPVEVQVSAV--WDTANTISETAYEISFRAHIPPLGLKVYKI--- 720
Query: 591 DAMSINKYTSFSHVRIYNADYWSVVLPKIFPIEQPSARLNEDVSFQAGNSTRVVT-NMNG 649
+ +S SH+ Y V IF I+ +N + NS ++ + G
Sbjct: 721 ----LESASSNSHLADYVLYKNKVEDSGIFTIKN---MINTEEGITLENSFVLLRFDQTG 773
Query: 650 LVKTIVSR-DGVATPVHMDFVQYDTQKGRDNNSGAYLFIPSGPAKDFKSDPYPEIVVTEG 708
L+K ++++ DG V++ F Y T RD SGAYLF+P G AK + P + VT G
Sbjct: 774 LMKQMMTKEDGKHHEVNVQFSWYGTTIKRD-KSGAYLFLPDGNAKPYVYTTPPFVRVTHG 832
Query: 709 IHKSTLYAALVGPKTAEIILSVTVYNNPSLPHAELEVSSALLIDPQVDDLELALRLSTSV 768
+Y+ V + V +Y+ + +EVS+ + I +V + E+A+++S+ +
Sbjct: 833 ----RIYSE-VTCFFDHVTHRVRLYHIQGIEGQSVEVSNIVDI-RKVYNREIAMKISSDI 886
Query: 769 RNGDVFYTDLNGMQMIKRRYFEKIPLQANFYPLPAAAYIEDENIRFTVLTSTPLGMAALQ 828
++ + FYTDLNG Q+ R K+PLQAN YP+ AYI+D R T+L++ LG+++L
Sbjct: 887 KSQNRFYTDLNGYQIQPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLN 946
Query: 829 PGQIEVMQDRRLSRDDNRGMNQGVLDNVRTRHTFRLIAEPALGHCAKPPSDHPSGWLTLG 888
GQIEV+ DRRL +DDNRG+ QG+ DN T + FR++ E + S + +L
Sbjct: 947 SGQIEVIMDRRLMQDDNRGLEQGIQDNKITANLFRILLEKRSAVNTEEEKKSVS-YPSLL 1005
Query: 889 SHVSQQMLLQP--PLVLHYTPRGDEPRPNYQRASVNAADIVLASYRTHTTTKKEGTNLHG 946
SH++ ++ P P+ ++P + S DI L + RT +K + +
Sbjct: 1006 SHITSSLMNHPVIPMANKFSPTLELQGEFSPLQSSLPCDIHLVNLRT-IQSKVGNGHSNE 1064
Query: 947 MGLTFQRVALDTCYGHKDTVEAYPLSDGQFRLSDLID 983
L R D + K T + G+ + L++
Sbjct: 1065 AALILHRKGFDCRFSSKGTGLFCSTTQGKILVQKLLN 1101
>U31520-1|AAC50302.1| 1144|Homo sapiens alpha mannosidase II protein.
Length = 1144
Score = 744 bits (1840), Expect = 0.0
Identities = 393/911 (43%), Positives = 561/911 (61%), Gaps = 36/911 (3%)
Query: 1 QMLSLYERIMFDDKDGGVWKQGWNIEYNENQWSQKNKLKVFIVPHSHNDPGWLKTFENYY 60
QML +Y I FD+ DGGVWKQG++I Y N+W + L+VF+VPHSHNDPGWLKTF +Y+
Sbjct: 130 QMLDVYSLISFDNPDGGVWKQGFDITYESNEWDTE-PLQVFVVPHSHNDPGWLKTFNDYF 188
Query: 61 KSQTRAIFNNMIEKLNEGVGRKFIWAEISFLSLWWNNDATEKDKTAFLNLLKSKKLEIVT 120
+ +T+ IFNNM+ KL E RKFIW+EIS+LS WW+ +K K A +L+++ +LEIVT
Sbjct: 189 RDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQK-KDAVKSLIENGQLEIVT 247
Query: 121 GGWVMNDEANSHWLSVVQQLTTGHQWLLDNLGYVPKNAWSIDPFGYSSAQPYLLKIAGFD 180
GGWVM DEA H+ +++ QL GHQWL +N+G P++ W+IDPFG+S YLL AG
Sbjct: 248 GGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYLLNRAGLS 307
Query: 181 NSMIQRVHYRIKKELASNRQLEFRWRQLWDGVGKTDMFTHLFPFYSYDVPHSCGPDPKIC 240
+ +IQRVHY +KK A ++ LEF WRQ WD TD+ H+ PFYSYD+PH+CGPDPKIC
Sbjct: 308 HMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTCGPDPKIC 367
Query: 241 CQFDFKRLPGNGVTCPWGVAPQRITQKNVDERAFKILDQWRKKAQLYRSNVLFFPLGDDF 300
CQFDFKRLPG CPWGV P+ I NV RA +LDQ+RKK++L+R+ VL PLGDDF
Sbjct: 368 CQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLLAPLGDDF 427
Query: 301 RYDHANEWDNQYQNYDMLIEYINSNDAWNTEVQYGTLEDYFKALH--DEVK----LSNFP 354
RY EWD Q++NY L +Y+NS + ++Q+GTL D+F AL DE + S FP
Sbjct: 428 RYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRDKGQSMFP 487
Query: 355 VLSGDFFTYADRNQHYWSGYYTSRPFYKNMDRVLLAYVRAAEII---TAQATDTHAVSYI 411
VLSGDFFTYADR+ HYWSGY+TSRPFYK MDR++ +++RAAEI+ + + ++
Sbjct: 488 VLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAHKYKINKF 547
Query: 412 MSLQLRDRVEQARRSLSLFQHHDGITGTSRDEVREDYAKKMLTAIKYSQSAIQQAAYYLL 471
+S L + +ARR+L LFQHHD ITGT++D V DY ++ ++ + I +A+ L+
Sbjct: 548 LSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIGNSAFLLI 607
Query: 472 -KQPHIQDQTQEDIFLDVDDIWRRHDEIPSRITIALDVVSPSRRLVLYNALAFRRQEILT 530
K D D FL++D + D +P + I L + R LV+YN L R +++
Sbjct: 608 GKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLS--AEPRYLVVYNPLEQDRISLVS 665
Query: 531 VLVSTPHVEVFDPEGEPIMAQVSPVVAGERRLGLANNKYQLSFPVTIGPLALTVYSVSLR 590
V VS+P V+VF G+P+ QVS V + ++ Y++SF I PL L VY +
Sbjct: 666 VYVSSPTVQVFSASGKPVEVQVSAV--WDTANTISETAYEISFRAHIPPLGLKVYKI--- 720
Query: 591 DAMSINKYTSFSHVRIYNADYWSVVLPKIFPIEQPSARLNEDVSFQAGNSTRVVT-NMNG 649
+ +S SH+ Y V IF I+ +N + NS ++ + G
Sbjct: 721 ----LESASSNSHLADYVLYKNKVEDSGIFTIKN---MINTEEGITLENSFVLLRFDQTG 773
Query: 650 LVKTIVSR-DGVATPVHMDFVQYDTQKGRDNNSGAYLFIPSGPAKDFKSDPYPEIVVTEG 708
L+K ++++ DG V++ F Y T RD SGAYLF+P G AK + P + VT G
Sbjct: 774 LMKQMMTKEDGKHHEVNVQFSWYGTTIKRD-KSGAYLFLPDGNAKPYVYTTPPFVRVTHG 832
Query: 709 IHKSTLYAALVGPKTAEIILSVTVYNNPSLPHAELEVSSALLIDPQVDDLELALRLSTSV 768
+Y+ V + V +Y+ + +EVS+ + I +V + E+A+++S+ +
Sbjct: 833 ----RIYSE-VTCFFDHVTHRVRLYHIQGIEGQSVEVSNIVDI-RKVYNREIAMKISSDI 886
Query: 769 RNGDVFYTDLNGMQMIKRRYFEKIPLQANFYPLPAAAYIEDENIRFTVLTSTPLGMAALQ 828
++ + FYTDLNG Q+ R K+PLQAN YP+ AYI+D R T+L++ LG+++L
Sbjct: 887 KSQNRFYTDLNGYQIQPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLN 946
Query: 829 PGQIEVMQDRRLSRDDNRGMNQGVLDNVRTRHTFRLIAEPALGHCAKPPSDHPSGWLTLG 888
GQIEV+ DRRL +DDNRG+ QG+ DN T + FR++ E + S + +L
Sbjct: 947 SGQIEVIMDRRLMQDDNRGLEQGIQDNKITANLFRILLEKRSAVNTEEEKKSVS-YPSLL 1005
Query: 889 SHVSQQMLLQP 899
SH++ ++ P
Sbjct: 1006 SHITSSLMNHP 1016
>D55649-1|BAA09510.1| 1139|Homo sapiens alpha mannosidase II isozyme
protein.
Length = 1139
Score = 638 bits (1575), Expect = 0.0
Identities = 327/706 (46%), Positives = 440/706 (62%), Gaps = 27/706 (3%)
Query: 1 QMLSLYERIMFDDKDGGVWKQGWNIEYNENQWSQKNKLKVFIVPHSHNDPGWLKTFENYY 60
QML++ E + FD+ DGGVW+QG++I Y+ + W ++ L+VF+VPHSHNDPGW+KTF+ YY
Sbjct: 130 QMLTVSEELPFDNVDGGVWRQGFDISYDPHDWDAED-LQVFVVPHSHNDPGWIKTFDKYY 188
Query: 61 KSQTRAIFNNMIEKLNEGVGRKFIWAEISFLSLWWNNDATEKDKTAFLNLLKSKKLEIVT 120
QT+ I N+M+ KL E R+F+WAE+SF + WW+N +K + A L+ + +LEI T
Sbjct: 189 TEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNINVQK-RAAVRRLVGNGQLEIAT 247
Query: 121 GGWVMNDEANSHWLSVVQQLTTGHQWLLDNLGYVPKNAWSIDPFGYSSAQPYLLKIAGFD 180
GGWVM DEANSH+ +++ QL GHQWL NLG P++ W++DPFGYSS PYLL+ A
Sbjct: 248 GGWVMPDEANSHYFALIDQLIEGHQWLERNLGATPRSGWAVDPFGYSSTMPYLLRRANLT 307
Query: 181 NSMIQRVHYRIKKELASNRQLEFRWRQLWDGVGKTDMFTHLFPFYSYDVPHSCGPDPKIC 240
+ +IQRVHY IKK A+ LEF WRQ WD TD+F H+ PFYSYDVPH+CGPDPKIC
Sbjct: 308 SMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKIC 367
Query: 241 CQFDFKRLPGNGVTCPWGVAPQRITQKNVDERAFKILDQWRKKAQLYRSNVLFFPLGDDF 300
CQFDFKRLPG + CPW V P+ IT+ NV ERA +LDQ+RKK+QL+RSNVL PLGDDF
Sbjct: 368 CQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQYRKKSQLFRSNVLLVPLGDDF 427
Query: 301 RYDHANEWDNQYQNYDMLIEYINSNDAWNTEVQYGTLEDYFKALHDEVKLS------NFP 354
RYD EWD Q+ NY L ++ NS + + Q+GTL DYF AL+ + FP
Sbjct: 428 RYDKPQEWDAQFFNYQRLFDFFNSRPNLHVQAQFGTLSDYFDALYKRTGVEPGARPPGFP 487
Query: 355 VLSGDFFTYADRNQHYWSGYYTSRPFYKNMDRVLLAYVRAAEII-TAQATDTHAVSYIMS 413
VLSGDFF+YADR HYW+GYYTSRPFYK++DRVL A++R AE++ + A
Sbjct: 488 VLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVLYSLAAAHARRSGLAGR 547
Query: 414 LQLRD--RVEQARRSLSLFQHHDGITGTSRDEVREDYAKKMLTAIKYSQSAIQQAAYYL- 470
L D + +ARR+L LFQHHD ITGT+++ V DY ++L ++ + I AA+YL
Sbjct: 548 YPLSDFTLLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVNLKQVIIHAAHYLV 607
Query: 471 LKQPHIQDQTQEDIFLDVDDIWRRHDEIPSRITIALDVVSPSRRLVLYNALAFRRQEILT 530
L E FL VDD HD +P R I LD S R +VL+N L R +++
Sbjct: 608 LGDKETYHFDPEAPFLQVDDTRLSHDALPERTVIQLD--SSPRFVVLFNPLEQERFSMVS 665
Query: 531 VLVSTPHVEVFDPEGEPIMAQVSPVVAGERRLGLANNKYQLSFPVTIGPLALTVYSVSLR 590
+LV++P V V EG+P+ Q+S + + YQ+S PV + L L V + L
Sbjct: 666 LLVNSPRVRVLSEEGQPLAVQISAHWSSATE--AVPDVYQVSVPVRLPALGLGVLQLQL- 722
Query: 591 DAMSINKYTSFSHVRIY-NADYWSVVLPKIFPIEQPSARLNEDVSFQAGNSTRVV--TNM 647
+ ++ T S VRIY + SV + FP+ + ++ F N V + +
Sbjct: 723 -GLDGHR-TLPSSVRIYLHGRQLSVSRHEAFPLRVIDSGTSD---FALSNRYMQVWFSGL 777
Query: 648 NGLVKTIVSRDGV-ATPVHMDFVQYDTQKGRDNNSGAYLFIPSGPA 692
GL+K+I D V M + Y T+ +D SGAYLF+P G A
Sbjct: 778 TGLLKSIRRVDEEHEQQVDMQVLVYGTRTSKD-KSGAYLFLPDGEA 822
Score = 110 bits (264), Expect = 3e-23
Identities = 58/140 (41%), Positives = 88/140 (62%), Gaps = 3/140 (2%)
Query: 765 STSVRNGDVFYTDLNGMQMIKRRYFEKIPLQANFYPLPAAAYIEDENIRFTVLTSTPLGM 824
+TS R+ + ++ RRY +K+PLQANFYP+P AYI+D R T+ T+ LG+
Sbjct: 878 TTSTRSWPCTSIQTSTARVQPRRYLKKLPLQANFYPMPVMAYIQDAQKRLTLHTAQALGV 937
Query: 825 AALQPGQIEVMQDRRLSRDDNRGMNQGVLDNVRTRHTFRLIAE-PALGHCAKPPSDHPSG 883
++L+ GQ+EV+ DRRL +DDNRG+ QG+ DN RT + FRL+ E +G ++ H +
Sbjct: 938 SSLKDGQLEVILDRRLMQDDNRGLGQGLKDNKRTCNRFRLLLERRTVG--SEVQDSHSTS 995
Query: 884 WLTLGSHVSQQMLLQPPLVL 903
+ +L SH++ L P L L
Sbjct: 996 YPSLLSHLTSMYLNAPALAL 1015
>L28821-1|AAA92022.1| 796|Homo sapiens alpha mannosidase II isozyme
protein.
Length = 796
Score = 620 bits (1531), Expect = e-177
Identities = 305/633 (48%), Positives = 407/633 (64%), Gaps = 20/633 (3%)
Query: 1 QMLSLYERIMFDDKDGGVWKQGWNIEYNENQWSQKNKLKVFIVPHSHNDPGWLKTFENYY 60
QML++ E + FD+ DGGVW+QG++I Y+ + W ++ L+VF+VPHSHNDPGW+KTF+ YY
Sbjct: 130 QMLTVSEELPFDNVDGGVWRQGFDISYDPHDWDAED-LQVFVVPHSHNDPGWIKTFDKYY 188
Query: 61 KSQTRAIFNNMIEKLNEGVGRKFIWAEISFLSLWWNNDATEKDKTAFLNLLKSKKLEIVT 120
QT+ I N+M+ KL E R+F+WAE+SF + WW+N +K + A L+ + +LEI T
Sbjct: 189 TEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNINVQK-RAAVRRLVGNGQLEIAT 247
Query: 121 GGWVMNDEANSHWLSVVQQLTTGHQWLLDNLGYVPKNAWSIDPFGYSSAQPYLLKIAGFD 180
GGWVM DEANSH+ +++ QL GHQWL NLG P++ W++DPFGYSS PYLL+ A
Sbjct: 248 GGWVMPDEANSHYFALIDQLIEGHQWLERNLGATPRSGWAVDPFGYSSTMPYLLRRANLT 307
Query: 181 NSMIQRVHYRIKKELASNRQLEFRWRQLWDGVGKTDMFTHLFPFYSYDVPHSCGPDPKIC 240
+ +IQRVHY IKK A+ LEF WRQ WD TD+F H+ PFYSYDVPH+CGPDPKIC
Sbjct: 308 SMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKIC 367
Query: 241 CQFDFKRLPGNGVTCPWGVAPQRITQKNVDERAFKILDQWRKKAQLYRSNVLFFPLGDDF 300
CQFDFKRLPG + CPW V P+ IT+ NV ERA +LDQ+RKK+QL+RSNVL PLGDDF
Sbjct: 368 CQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQYRKKSQLFRSNVLLVPLGDDF 427
Query: 301 RYDHANEWDNQYQNYDMLIEYINSNDAWNTEVQYGTLEDYFKALHDEVKLS------NFP 354
RYD EWD Q+ NY L ++ NS + + Q+GTL DYF AL+ + FP
Sbjct: 428 RYDKPQEWDAQFFNYQRLFDFFNSRPNLHVQAQFGTLSDYFDALYKRTGVEPGARPPGFP 487
Query: 355 VLSGDFFTYADRNQHYWSGYYTSRPFYKNMDRVLLAYVRAAEII-TAQATDTHAVSYIMS 413
VLSGDFF+YADR HYW+GYYTSRPFYK++DRVL A++R AE++ + A
Sbjct: 488 VLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVLYSLAAAHARRSGLAGR 547
Query: 414 LQLRD--RVEQARRSLSLFQHHDGITGTSRDEVREDYAKKMLTAIKYSQSAIQQAAYYL- 470
L D + +ARR+L LFQHHD ITGT+++ V DY ++L ++ + I AA+YL
Sbjct: 548 YPLSDFTLLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVNLKQVIIHAAHYLV 607
Query: 471 LKQPHIQDQTQEDIFLDVDDIWRRHDEIPSRITIALDVVSPSRRLVLYNALAFRRQEILT 530
L E FL VDD HD +P R I LD S R +VL+N L R +++
Sbjct: 608 LGDKETYHFDPEAPFLQVDDTRLSHDALPERTVIQLD--SSPRFVVLFNPLEQERFSMVS 665
Query: 531 VLVSTPHVEVFDPEGEPIMAQVSPVVAGERRLGLANNKYQLSFPVTIGPLALTVYSVSLR 590
+LV++P V V EG+P+ Q+S + + YQ+S PV + L L V + L
Sbjct: 666 LLVNSPRVRVLSEEGQPLAVQISAHWSSATE--AVPDVYQVSVPVRLPALGLGVLQLQL- 722
Query: 591 DAMSINKYTSFSHVRIY-NADYWSVVLPKIFPI 622
+ ++ T S VRIY + SV + FP+
Sbjct: 723 -GLDGHR-TLPSSVRIYLHGRQLSVSRHEAFPL 753
>BC094773-1|AAH94773.1| 1009|Homo sapiens mannosidase, alpha, class
2B, member 2 protein.
Length = 1009
Score = 219 bits (536), Expect = 3e-56
Identities = 131/424 (30%), Positives = 222/424 (52%), Gaps = 12/424 (2%)
Query: 38 LKVFIVPHSHNDPGWLKTFENYYKSQTRAIFNNMIEKLNEGVGRKFIWAEISFLSLWWNN 97
++ F+VPHSH D GW+ T + ++ ++ +++E+L G R+FI E F LWW+
Sbjct: 27 IRAFVVPHSHMDVGWVYTVQESMRAYAANVYTSVVEELARGQQRRFIAVEQEFFRLWWDG 86
Query: 98 DATEKDKTAFLNLLKSKKLEIVTGGWVMNDEANSHWLSVVQQLTTGHQWLLDNLGYVPKN 157
A+++ K LL+ +LE V GG VM+DEA +H + QLT GH +L + G P+
Sbjct: 87 VASDQQKYQVRQLLEEGRLEFVIGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGIRPQF 146
Query: 158 AWSIDPFGYSSAQPYLLKIAGFDNSMIQRVHYRIKKELASNRQLEFRWRQLWDGVGKTDM 217
+W +DPFG S+ P L +AGF+ + R+ Y +K + R L+F WR + ++
Sbjct: 147 SWHVDPFGASATTPTLFALAGFNAHLGSRIDYDLKAAMQEARGLQFVWRGSPSLSERQEI 206
Query: 218 FTHLFPFYSYDVPHSCGPDPKICCQFD----FKRLPGNGVTCPWGVAPQRITQKNVDERA 273
FTH+ YSY P + ++ F + P +GV + + +T N++ A
Sbjct: 207 FTHIMDQYSYCTPSHIPFSNRSGFYWNGVAVFPKPPPDGV---YPNMSEPVTPANINLYA 263
Query: 274 FKILDQWRKKAQLYRSNVLFFPLGDDFRYDHANEWDNQYQNYDMLIEYINSNDA-WNTEV 332
++ +++A +R+ + +P G D ++ +A+ Q+ N D L+++INS+ A V
Sbjct: 264 EALVANVKQRAAWFRTPHVLWPWGCDKQFFNASV---QFANMDPLLDHINSHAAELGVSV 320
Query: 333 QYGTLEDYFKALHDEVKLSNFPVLSGDFFTYADRNQHYWSGYYTSRPFYKNMDRVLLAYV 392
QY TL DYF+ALH + ++ DF Y+ W+G+YTSR K + R A +
Sbjct: 321 QYATLGDYFRALH-ALNVTWRVRDHHDFLPYSTEPFQAWTGFYTSRSSLKGLARRASALL 379
Query: 393 RAAEIITAQATDTHAVSYIMSLQLRDRVEQARRSLSLFQHHDGITGTSRDEVREDYAKKM 452
A E + + ++ +++Q R ++S QHHD ITGT +VR+ YA +
Sbjct: 380 YAGESMFTRYLWPAPRGHLDPTWALQQLQQLRWAVSEVQHHDAITGTESPKVRDMYATHL 439
Query: 453 LTAI 456
+ +
Sbjct: 440 ASGM 443
Score = 60.1 bits (139), Expect = 4e-08
Identities = 31/84 (36%), Positives = 49/84 (58%), Gaps = 2/84 (2%)
Query: 759 ELALRLSTSVRNGDVFYTDLNGMQMIKRRYFEKI--PLQANFYPLPAAAYIEDENIRFTV 816
E LR ST++ + V Y+D NG QM +R Y + + N+YP+ +A++ED R +
Sbjct: 714 EAVLRTSTNLNSQQVIYSDNNGYQMQRRPYVSYVNNSIARNYYPMVQSAFMEDGKSRLVL 773
Query: 817 LTSTPLGMAALQPGQIEVMQDRRL 840
L+ G+++ GQ+EVM RRL
Sbjct: 774 LSERAHGISSQGNGQVEVMLHRRL 797
>BC033307-1|AAH33307.1| 1009|Homo sapiens mannosidase, alpha, class
2B, member 2 protein.
Length = 1009
Score = 219 bits (536), Expect = 3e-56
Identities = 131/424 (30%), Positives = 222/424 (52%), Gaps = 12/424 (2%)
Query: 38 LKVFIVPHSHNDPGWLKTFENYYKSQTRAIFNNMIEKLNEGVGRKFIWAEISFLSLWWNN 97
++ F+VPHSH D GW+ T + ++ ++ +++E+L G R+FI E F LWW+
Sbjct: 27 IRAFVVPHSHMDVGWVYTVQESMRAYAANVYTSVVEELARGQQRRFIAVEQEFFRLWWDG 86
Query: 98 DATEKDKTAFLNLLKSKKLEIVTGGWVMNDEANSHWLSVVQQLTTGHQWLLDNLGYVPKN 157
A+++ K LL+ +LE V GG VM+DEA +H + QLT GH +L + G P+
Sbjct: 87 VASDQQKYQVRQLLEEGRLEFVIGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGIRPQF 146
Query: 158 AWSIDPFGYSSAQPYLLKIAGFDNSMIQRVHYRIKKELASNRQLEFRWRQLWDGVGKTDM 217
+W +DPFG S+ P L +AGF+ + R+ Y +K + R L+F WR + ++
Sbjct: 147 SWHVDPFGASATTPTLFALAGFNAHLGSRIDYDLKAAMQEARGLQFVWRGSPSLSERQEI 206
Query: 218 FTHLFPFYSYDVPHSCGPDPKICCQFD----FKRLPGNGVTCPWGVAPQRITQKNVDERA 273
FTH+ YSY P + ++ F + P +GV + + +T N++ A
Sbjct: 207 FTHIMDQYSYCTPSHIPFSNRSGFYWNGVAVFPKPPPDGV---YPNMSEPVTPANINLYA 263
Query: 274 FKILDQWRKKAQLYRSNVLFFPLGDDFRYDHANEWDNQYQNYDMLIEYINSNDA-WNTEV 332
++ +++A +R+ + +P G D ++ +A+ Q+ N D L+++INS+ A V
Sbjct: 264 EALVANVKQRAAWFRTPHVLWPWGCDKQFFNASV---QFANMDPLLDHINSHAAELGVSV 320
Query: 333 QYGTLEDYFKALHDEVKLSNFPVLSGDFFTYADRNQHYWSGYYTSRPFYKNMDRVLLAYV 392
QY TL DYF+ALH + ++ DF Y+ W+G+YTSR K + R A +
Sbjct: 321 QYATLGDYFRALH-ALNVTWRVRDHHDFLPYSTEPFQAWTGFYTSRSSLKGLARRASALL 379
Query: 393 RAAEIITAQATDTHAVSYIMSLQLRDRVEQARRSLSLFQHHDGITGTSRDEVREDYAKKM 452
A E + + ++ +++Q R ++S QHHD ITGT +VR+ YA +
Sbjct: 380 YAGESMFTRYLWPAPRGHLDPTWALQQLQQLRWAVSEVQHHDAITGTESPKVRDMYATHL 439
Query: 453 LTAI 456
+ +
Sbjct: 440 ASGM 443
Score = 60.1 bits (139), Expect = 4e-08
Identities = 31/84 (36%), Positives = 49/84 (58%), Gaps = 2/84 (2%)
Query: 759 ELALRLSTSVRNGDVFYTDLNGMQMIKRRYFEKI--PLQANFYPLPAAAYIEDENIRFTV 816
E LR ST++ + V Y+D NG QM +R Y + + N+YP+ +A++ED R +
Sbjct: 714 EAVLRTSTNLNSQQVIYSDNNGYQMQRRPYVSYVNNSIARNYYPMVQSAFMEDGKSRLVL 773
Query: 817 LTSTPLGMAALQPGQIEVMQDRRL 840
L+ G+++ GQ+EVM RRL
Sbjct: 774 LSERAHGISSQGNGQVEVMLHRRL 797
>AB023152-1|BAA76779.2| 952|Homo sapiens KIAA0935 protein protein.
Length = 952
Score = 219 bits (536), Expect = 3e-56
Identities = 131/424 (30%), Positives = 222/424 (52%), Gaps = 12/424 (2%)
Query: 38 LKVFIVPHSHNDPGWLKTFENYYKSQTRAIFNNMIEKLNEGVGRKFIWAEISFLSLWWNN 97
++ F+VPHSH D GW+ T + ++ ++ +++E+L G R+FI E F LWW+
Sbjct: 25 IRAFVVPHSHMDVGWVYTVQESMRAYAANVYTSVVEELARGQQRRFIAVEQEFFRLWWDG 84
Query: 98 DATEKDKTAFLNLLKSKKLEIVTGGWVMNDEANSHWLSVVQQLTTGHQWLLDNLGYVPKN 157
A+++ K LL+ +LE V GG VM+DEA +H + QLT GH +L + G P+
Sbjct: 85 VASDQQKYQVRQLLEEGRLEFVIGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGIRPQF 144
Query: 158 AWSIDPFGYSSAQPYLLKIAGFDNSMIQRVHYRIKKELASNRQLEFRWRQLWDGVGKTDM 217
+W +DPFG S+ P L +AGF+ + R+ Y +K + R L+F WR + ++
Sbjct: 145 SWHVDPFGASATTPTLFALAGFNAHLGSRIDYDLKAAMQEARGLQFVWRGSPSLSERQEI 204
Query: 218 FTHLFPFYSYDVPHSCGPDPKICCQFD----FKRLPGNGVTCPWGVAPQRITQKNVDERA 273
FTH+ YSY P + ++ F + P +GV + + +T N++ A
Sbjct: 205 FTHIMDQYSYCTPSHIPFSNRSGFYWNGVAVFPKPPPDGV---YPNMSEPVTPANINLYA 261
Query: 274 FKILDQWRKKAQLYRSNVLFFPLGDDFRYDHANEWDNQYQNYDMLIEYINSNDA-WNTEV 332
++ +++A +R+ + +P G D ++ +A+ Q+ N D L+++INS+ A V
Sbjct: 262 EALVANVKQRAAWFRTPHVLWPWGCDKQFFNASV---QFANMDPLLDHINSHAAELGVSV 318
Query: 333 QYGTLEDYFKALHDEVKLSNFPVLSGDFFTYADRNQHYWSGYYTSRPFYKNMDRVLLAYV 392
QY TL DYF+ALH + ++ DF Y+ W+G+YTSR K + R A +
Sbjct: 319 QYATLGDYFRALH-ALNVTWRVRDHHDFLPYSTEPFQAWTGFYTSRSSLKGLARRASALL 377
Query: 393 RAAEIITAQATDTHAVSYIMSLQLRDRVEQARRSLSLFQHHDGITGTSRDEVREDYAKKM 452
A E + + ++ +++Q R ++S QHHD ITGT +VR+ YA +
Sbjct: 378 YAGESMFTRYLWPAPRGHLDPTWALQQLQQLRWAVSEVQHHDAITGTESPKVRDMYATHL 437
Query: 453 LTAI 456
+ +
Sbjct: 438 ASGM 441
Score = 60.1 bits (139), Expect = 4e-08
Identities = 31/84 (36%), Positives = 49/84 (58%), Gaps = 2/84 (2%)
Query: 759 ELALRLSTSVRNGDVFYTDLNGMQMIKRRYFEKI--PLQANFYPLPAAAYIEDENIRFTV 816
E LR ST++ + V Y+D NG QM +R Y + + N+YP+ +A++ED R +
Sbjct: 712 EAVLRTSTNLNSQQVIYSDNNGYQMQRRPYVSYVNNSIARNYYPMVQSAFMEDGKSRLVL 771
Query: 817 LTSTPLGMAALQPGQIEVMQDRRL 840
L+ G+++ GQ+EVM RRL
Sbjct: 772 LSERAHGISSQGNGQVEVMLHRRL 795
>AL833071-1|CAD89971.1| 1009|Homo sapiens hypothetical protein
protein.
Length = 1009
Score = 215 bits (525), Expect = 7e-55
Identities = 129/424 (30%), Positives = 221/424 (52%), Gaps = 12/424 (2%)
Query: 38 LKVFIVPHSHNDPGWLKTFENYYKSQTRAIFNNMIEKLNEGVGRKFIWAEISFLSLWWNN 97
++ F+VPHSH D GW+ T + ++ ++ +++E+L G R+FI E LWW+
Sbjct: 27 IRAFVVPHSHMDVGWVYTVQESMRAYAANVYTSVVEELARGQQRRFIAVEQESFRLWWDG 86
Query: 98 DATEKDKTAFLNLLKSKKLEIVTGGWVMNDEANSHWLSVVQQLTTGHQWLLDNLGYVPKN 157
A+++ K LL+ +LE V GG VM+DEA +H + QLT GH +L + G P+
Sbjct: 87 VASDQQKYQVRQLLEEGRLEFVIGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGIRPQF 146
Query: 158 AWSIDPFGYSSAQPYLLKIAGFDNSMIQRVHYRIKKELASNRQLEFRWRQLWDGVGKTDM 217
+W +DPFG S+ P L +AGF+ + R+ Y +K + R L+F WR + ++
Sbjct: 147 SWHVDPFGASATTPTLFALAGFNAHLGSRIDYDLKAAMQEARGLQFVWRGSPSLSERQEI 206
Query: 218 FTHLFPFYSYDVPHSCGPDPKICCQFD----FKRLPGNGVTCPWGVAPQRITQKNVDERA 273
FTH+ YSY P + ++ F + P +GV + + +T N++ A
Sbjct: 207 FTHIMDQYSYCTPSHIPFSNRSGFYWNGVAVFPKPPQDGV---YPNMSEPVTPANINLYA 263
Query: 274 FKILDQWRKKAQLYRSNVLFFPLGDDFRYDHANEWDNQYQNYDMLIEYINSNDA-WNTEV 332
++ +++A +R+ + +P G D ++ +A+ Q+ N D L+++INS+ A +
Sbjct: 264 EALVANVKQRAAWFRTPHVLWPWGCDKQFFNASV---QFANMDPLLDHINSHAAELGVSM 320
Query: 333 QYGTLEDYFKALHDEVKLSNFPVLSGDFFTYADRNQHYWSGYYTSRPFYKNMDRVLLAYV 392
QY TL DYF+ALH + ++ DF Y+ W+G+YTSR K + R A +
Sbjct: 321 QYATLGDYFRALH-ALNVTWRVRDHHDFLPYSTEPFQAWTGFYTSRSSLKGLARRASALL 379
Query: 393 RAAEIITAQATDTHAVSYIMSLQLRDRVEQARRSLSLFQHHDGITGTSRDEVREDYAKKM 452
A E + + ++ +++Q R ++S QHHD ITGT +VR+ YA +
Sbjct: 380 YAGESMFTRYLWPAPRGHLDPTWALQQLQQLRWAVSEVQHHDAITGTESPKVRDMYATHL 439
Query: 453 LTAI 456
+ +
Sbjct: 440 ASGM 443
Score = 60.1 bits (139), Expect = 4e-08
Identities = 31/84 (36%), Positives = 49/84 (58%), Gaps = 2/84 (2%)
Query: 759 ELALRLSTSVRNGDVFYTDLNGMQMIKRRYFEKI--PLQANFYPLPAAAYIEDENIRFTV 816
E LR ST++ + V Y+D NG QM +R Y + + N+YP+ +A++ED R +
Sbjct: 714 EAVLRTSTNLNSQQVIYSDNNGYQMQRRPYVSYVNNSIARNYYPMVQSAFMEDGKSRLVL 773
Query: 817 LTSTPLGMAALQPGQIEVMQDRRL 840
L+ G+++ GQ+EVM RRL
Sbjct: 774 LSERAHGISSQGNGQVEVMLHRRL 797
>U68567-1|AAC50812.1| 988|Homo sapiens lysosomal acid
alpha-mannosidase protein.
Length = 988
Score = 198 bits (483), Expect = 8e-50
Identities = 135/432 (31%), Positives = 213/432 (49%), Gaps = 38/432 (8%)
Query: 34 QKNKLKVFIVPHSHNDPGWLKTFENYY--------KSQTRAIFNNMIEKLNEGVGRKFIW 85
Q N L V ++PH+H+D GWLKT + Y+ + + I +++I L R+FI+
Sbjct: 36 QPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIY 95
Query: 86 AEISFLSLWWNNDATEKDKTAFLNLLKSKKLEIVTGGWVMNDEANSHWLSVVQQLTTGHQ 145
EI+F S WW+ T + +L++ +LE GGWVMNDEA +H+ ++V Q+T G +
Sbjct: 96 VEIAFFSRWWHQQ-TNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLR 154
Query: 146 WLLDNLGYV--PKNAWSIDPFGYSSAQPYLLKIAGFDNSMIQRVHYRIKKELASNRQLEF 203
+L D G P+ AW IDPFG+S Q L GFD R+ Y+ K ++E
Sbjct: 155 FLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQ 214
Query: 204 RWRQLWDGVGKT-DMFTHLFPFYSYDVPHSCGPDPKICCQFDFKRLPGNGVTCPWGVAPQ 262
WR T D+FT + P Y+ P + D + C V P V
Sbjct: 215 VWRASTSLKPPTADLFTGVLP-NGYNPPRNLCWD--VLC-----------VDQPL-VEDP 259
Query: 263 RITQKNVDERAFKILDQWRKKAQLYRSNVLFFPLGDDFRYDHANEWDNQYQNYDMLIEYI 322
R + N E L+ + + YR+N + +G DF+Y++AN W ++N D LI+ +
Sbjct: 260 RSPEYNAKELVDYFLNVATAQGRYYRTNHIVMTMGSDFQYENANMW---FKNLDKLIQLV 316
Query: 323 NSNDAWNTEVQ--YGTLEDYFKALHDEVKLSNFPVLSGDFFTYADRNQHYWSGYYTSRPF 380
N+ A + V Y T Y L+ + L+ + V DFF YAD + +W+GY++SRP
Sbjct: 317 NAQQAKGSSVHVLYSTPACYLWELN-KANLT-WSVKHDDFFPYADGHHQFWTGYFSSRPA 374
Query: 381 YKNMDRVLLAYVRAAEIITAQATDTHAVSYIMSLQLRDRVEQARRSLSLFQHHDGITGTS 440
K +R+ +++ + A V S ++++ QHHD ++GTS
Sbjct: 375 LKRYERLSYNFLQVCNQLEALVGLAANVGPYGS----GDSAPLNEAMAVLQHHDAVSGTS 430
Query: 441 RDEVREDYAKKM 452
R V DYA+++
Sbjct: 431 RQHVANDYARQL 442
Score = 77.4 bits (182), Expect = 2e-13
Identities = 68/229 (29%), Positives = 108/229 (47%), Gaps = 24/229 (10%)
Query: 649 GLVKTIVSRDG-VATPVHMDFVQYDTQKG---RDNNSGAYLFIPSGPAKDFKSDPYPEIV 704
GL+ I++ + + PV F Y+ G D SGAY+F P+ K + +I
Sbjct: 598 GLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAYIFRPN-QQKPLPVSRWAQIH 656
Query: 705 VTEGIHKSTLYAALVGPKTAEIILSVTVYNNPSLPHAELEVSSALLIDPQVDDLELALRL 764
+ K+ L + +A V +Y P H ELE S + E+ R
Sbjct: 657 LV----KTPLVQEVHQNFSAWCSQVVRLY--PGQRHLELEWSVGPIPVGDTWGKEVISRF 710
Query: 765 STSVRNGDVFYTDLNGMQMIKRR--------YFEKIPLQANFYPLPAAAYIEDENIRFTV 816
T + FYTD NG ++++RR + P+ N+YP+ YI D N++ TV
Sbjct: 711 DTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTV 770
Query: 817 LTSTPLGMAALQPGQIEVMQDRRLSRDDNRGMNQGVLDN-----VRTRH 860
LT G ++L+ G +E+M RRL +DD RG+++ +++N VR RH
Sbjct: 771 LTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVRGRH 819
>U60266-1|AAC34130.1| 1011|Homo sapiens lysosomal alpha-mannosidase
protein.
Length = 1011
Score = 198 bits (482), Expect = 1e-49
Identities = 136/432 (31%), Positives = 211/432 (48%), Gaps = 38/432 (8%)
Query: 34 QKNKLKVFIVPHSHNDPGWLKTFENYY--------KSQTRAIFNNMIEKLNEGVGRKFIW 85
Q N L V ++PH+H+D GWLKT + Y+ + + I +++I L R+FI+
Sbjct: 59 QPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIY 118
Query: 86 AEISFLSLWWNNDATEKDKTAFLNLLKSKKLEIVTGGWVMNDEANSHWLSVVQQLTTGHQ 145
EI+F S WW+ T + +L++ +LE GGWVMNDEA +H+ ++V Q+T G +
Sbjct: 119 VEIAFFSRWWHQQ-TNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLR 177
Query: 146 WLLDNLGYV--PKNAWSIDPFGYSSAQPYLLKIAGFDNSMIQRVHYRIKKELASNRQLEF 203
+L D G V P+ AW IDPFG+S Q L GFD R+ Y+ K ++E
Sbjct: 178 FLEDTFGNVGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQ 237
Query: 204 RWRQLWDGVGKT-DMFTHLFPFYSYDVPHSCGPDPKICCQFDFKRLPGNGVTCPWGVAPQ 262
WR T D+FT + P Y+ P + D + C V P V
Sbjct: 238 VWRASTSLKPPTADLFTGVLP-NGYNPPRNLCWD--VLC-----------VDQPL-VEDP 282
Query: 263 RITQKNVDERAFKILDQWRKKAQLYRSNVLFFPLGDDFRYDHANEWDNQYQNYDMLIEYI 322
R + N E L+ + + YR+N +G DF+Y++AN W ++N D LI +
Sbjct: 283 RSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQYENANMW---FKNLDKLIRLV 339
Query: 323 NSNDAWNTEVQ--YGTLEDYFKALHDEVKLSNFPVLSGDFFTYADRNQHYWSGYYTSRPF 380
N+ A + V Y T Y L+ + L+ + V DFF YAD +W+GY++SRP
Sbjct: 340 NAQQAKGSSVHVLYSTPACYLWELN-KANLT-WSVKHDDFFPYADGPHQFWTGYFSSRPA 397
Query: 381 YKNMDRVLLAYVRAAEIITAQATDTHAVSYIMSLQLRDRVEQARRSLSLFQHHDGITGTS 440
K +R+ +++ + A V S ++++ QHHD ++GTS
Sbjct: 398 LKRYERLSYNFLQVCNQLEALVGLAANVGPYGS----GDSAPLNEAMAVLQHHDAVSGTS 453
Query: 441 RDEVREDYAKKM 452
R V DYA+++
Sbjct: 454 RQHVANDYARQL 465
Score = 77.4 bits (182), Expect = 2e-13
Identities = 68/229 (29%), Positives = 108/229 (47%), Gaps = 24/229 (10%)
Query: 649 GLVKTIVSRDG-VATPVHMDFVQYDTQKG---RDNNSGAYLFIPSGPAKDFKSDPYPEIV 704
GL+ I++ + + PV F Y+ G D SGAY+F P+ K + +I
Sbjct: 621 GLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAYIFRPN-QQKPLPVSRWAQIH 679
Query: 705 VTEGIHKSTLYAALVGPKTAEIILSVTVYNNPSLPHAELEVSSALLIDPQVDDLELALRL 764
+ K+ L + +A V +Y P H ELE S + E+ R
Sbjct: 680 LV----KTPLVQEVHQNFSAWCSQVVRLY--PGQRHLELEWSVGPIPVGDTWGKEVISRF 733
Query: 765 STSVRNGDVFYTDLNGMQMIKRR--------YFEKIPLQANFYPLPAAAYIEDENIRFTV 816
T + FYTD NG ++++RR + P+ N+YP+ YI D N++ TV
Sbjct: 734 DTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTV 793
Query: 817 LTSTPLGMAALQPGQIEVMQDRRLSRDDNRGMNQGVLDN-----VRTRH 860
LT G ++L+ G +E+M RRL +DD RG+++ +++N VR RH
Sbjct: 794 LTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVRGRH 842
>AB209921-1|BAD93158.1| 1007|Homo sapiens mannosidase, alpha, class
2B, member 1 precursor variant protein.
Length = 1007
Score = 197 bits (480), Expect = 2e-49
Identities = 135/432 (31%), Positives = 212/432 (49%), Gaps = 38/432 (8%)
Query: 34 QKNKLKVFIVPHSHNDPGWLKTFENYY--------KSQTRAIFNNMIEKLNEGVGRKFIW 85
Q N L V ++PH+H+D GWLKT + Y+ + + I +++I L R+FI+
Sbjct: 55 QPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIY 114
Query: 86 AEISFLSLWWNNDATEKDKTAFLNLLKSKKLEIVTGGWVMNDEANSHWLSVVQQLTTGHQ 145
EI+F S WW+ T + +L++ +LE GGWVMNDEA +H+ ++V Q+T G +
Sbjct: 115 VEIAFFSRWWHQQ-TNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLR 173
Query: 146 WLLDNLGYV--PKNAWSIDPFGYSSAQPYLLKIAGFDNSMIQRVHYRIKKELASNRQLEF 203
+L D G P+ AW IDPFG+S Q L GFD R+ Y+ K ++E
Sbjct: 174 FLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQ 233
Query: 204 RWRQLWDGVGKT-DMFTHLFPFYSYDVPHSCGPDPKICCQFDFKRLPGNGVTCPWGVAPQ 262
WR T D+FT + P Y+ P + D + C V P V
Sbjct: 234 VWRASTSLKPPTADLFTGVLP-NGYNPPRNLCWD--VLC-----------VDQPL-VEDP 278
Query: 263 RITQKNVDERAFKILDQWRKKAQLYRSNVLFFPLGDDFRYDHANEWDNQYQNYDMLIEYI 322
R + N E L+ + + YR+N + +G DF+Y++AN W ++N D LI+ +
Sbjct: 279 RSPEYNAKELVDYFLNVATAQGRYYRTNHIVMTMGSDFQYENANMW---FKNLDKLIQLV 335
Query: 323 NSNDAWNTEVQ--YGTLEDYFKALHDEVKLSNFPVLSGDFFTYADRNQHYWSGYYTSRPF 380
N+ A + V Y T Y L+ + L+ + V DFF YAD +W+GY++SRP
Sbjct: 336 NAQQAKGSSVHVLYSTPACYLWELN-KANLT-WSVKHDDFFPYADGPHQFWTGYFSSRPA 393
Query: 381 YKNMDRVLLAYVRAAEIITAQATDTHAVSYIMSLQLRDRVEQARRSLSLFQHHDGITGTS 440
K +R+ +++ + A V S ++++ QHHD ++GTS
Sbjct: 394 LKRYERLSYNFLQVCNQLEALVGLAANVGPYGS----GDSAPLNEAMAVLQHHDAVSGTS 449
Query: 441 RDEVREDYAKKM 452
R V DYA+++
Sbjct: 450 RQHVANDYARQL 461
Score = 77.4 bits (182), Expect = 2e-13
Identities = 68/229 (29%), Positives = 108/229 (47%), Gaps = 24/229 (10%)
Query: 649 GLVKTIVSRDG-VATPVHMDFVQYDTQKG---RDNNSGAYLFIPSGPAKDFKSDPYPEIV 704
GL+ I++ + + PV F Y+ G D SGAY+F P+ K + +I
Sbjct: 617 GLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAYIFRPN-QQKPLPVSRWAQIH 675
Query: 705 VTEGIHKSTLYAALVGPKTAEIILSVTVYNNPSLPHAELEVSSALLIDPQVDDLELALRL 764
+ K+ L + +A V +Y P H ELE S + E+ R
Sbjct: 676 LV----KTPLVQEVHQNFSAWCSQVVRLY--PGQRHLELEWSVGPIPVGDTWGKEVISRF 729
Query: 765 STSVRNGDVFYTDLNGMQMIKRR--------YFEKIPLQANFYPLPAAAYIEDENIRFTV 816
T + FYTD NG ++++RR + P+ N+YP+ YI D N++ TV
Sbjct: 730 DTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTV 789
Query: 817 LTSTPLGMAALQPGQIEVMQDRRLSRDDNRGMNQGVLDN-----VRTRH 860
LT G ++L+ G +E+M RRL +DD RG+++ +++N VR RH
Sbjct: 790 LTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVRGRH 838
>U60899-1|AAC51362.1| 1010|Homo sapiens lysosomal alpha-mannosidase
protein.
Length = 1010
Score = 195 bits (475), Expect = 8e-49
Identities = 135/432 (31%), Positives = 210/432 (48%), Gaps = 38/432 (8%)
Query: 34 QKNKLKVFIVPHSHNDPGWLKTFENYY--------KSQTRAIFNNMIEKLNEGVGRKFIW 85
Q N L V ++PH+H+D GWLKT + Y+ + + I +++I L R+FI+
Sbjct: 58 QPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIY 117
Query: 86 AEISFLSLWWNNDATEKDKTAFLNLLKSKKLEIVTGGWVMNDEANSHWLSVVQQLTTGHQ 145
EI+F S WW+ T + +L++ +LE GGWVMNDEA +H+ ++V Q+T G +
Sbjct: 118 VEIAFFSRWWHQQ-TNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLR 176
Query: 146 WLLDNLGYV--PKNAWSIDPFGYSSAQPYLLKIAGFDNSMIQRVHYRIKKELASNRQLEF 203
+L D G P+ AW IDPFG+S Q L GFD R+ Y+ K ++E
Sbjct: 177 FLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQ 236
Query: 204 RWRQLWDGVGKT-DMFTHLFPFYSYDVPHSCGPDPKICCQFDFKRLPGNGVTCPWGVAPQ 262
WR T D+FT + P Y+ P + D + C V P V
Sbjct: 237 VWRASTSLKPPTADLFTGVLP-NGYNPPRNLCWD--VLC-----------VDQPL-VEDP 281
Query: 263 RITQKNVDERAFKILDQWRKKAQLYRSNVLFFPLGDDFRYDHANEWDNQYQNYDMLIEYI 322
R + N E L+ + + YR+N +G DF+Y++AN W ++N D LI +
Sbjct: 282 RSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQYENANMW---FKNLDKLIRLV 338
Query: 323 NSNDAWNTEVQ--YGTLEDYFKALHDEVKLSNFPVLSGDFFTYADRNQHYWSGYYTSRPF 380
N+ A + V Y T Y L+ + L+ + V DFF YAD +W+GY++SRP
Sbjct: 339 NAQQAKGSSVHVLYSTPACYLWELN-KANLT-WSVKHDDFFPYADGPHQFWTGYFSSRPA 396
Query: 381 YKNMDRVLLAYVRAAEIITAQATDTHAVSYIMSLQLRDRVEQARRSLSLFQHHDGITGTS 440
K +R+ +++ + A V S ++++ QHHD ++GTS
Sbjct: 397 LKRYERLSYNFLQVCNQLEALVGLAANVGPYGS----GDSAPLNEAMAVLQHHDAVSGTS 452
Query: 441 RDEVREDYAKKM 452
R V DYA+++
Sbjct: 453 RQHVANDYARQL 464
Score = 77.4 bits (182), Expect = 2e-13
Identities = 68/229 (29%), Positives = 108/229 (47%), Gaps = 24/229 (10%)
Query: 649 GLVKTIVSRDG-VATPVHMDFVQYDTQKG---RDNNSGAYLFIPSGPAKDFKSDPYPEIV 704
GL+ I++ + + PV F Y+ G D SGAY+F P+ K + +I
Sbjct: 620 GLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAYIFRPN-QQKPLPVSRWAQIH 678
Query: 705 VTEGIHKSTLYAALVGPKTAEIILSVTVYNNPSLPHAELEVSSALLIDPQVDDLELALRL 764
+ K+ L + +A V +Y P H ELE S + E+ R
Sbjct: 679 LV----KTPLVQEVHQNFSAWCSQVVRLY--PGQRHLELEWSVGPIPVGDTWGKEVISRF 732
Query: 765 STSVRNGDVFYTDLNGMQMIKRR--------YFEKIPLQANFYPLPAAAYIEDENIRFTV 816
T + FYTD NG ++++RR + P+ N+YP+ YI D N++ TV
Sbjct: 733 DTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTV 792
Query: 817 LTSTPLGMAALQPGQIEVMQDRRLSRDDNRGMNQGVLDN-----VRTRH 860
LT G ++L+ G +E+M RRL +DD RG+++ +++N VR RH
Sbjct: 793 LTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVRGRH 841
>BC000736-1|AAH00736.1| 1011|Homo sapiens mannosidase, alpha, class
2B, member 1 protein.
Length = 1011
Score = 195 bits (475), Expect = 8e-49
Identities = 135/432 (31%), Positives = 210/432 (48%), Gaps = 38/432 (8%)
Query: 34 QKNKLKVFIVPHSHNDPGWLKTFENYY--------KSQTRAIFNNMIEKLNEGVGRKFIW 85
Q N L V ++PH+H+D GWLKT + Y+ + + I +++I L R+FI+
Sbjct: 59 QPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIY 118
Query: 86 AEISFLSLWWNNDATEKDKTAFLNLLKSKKLEIVTGGWVMNDEANSHWLSVVQQLTTGHQ 145
EI+F S WW+ T + +L++ +LE GGWVMNDEA +H+ ++V Q+T G +
Sbjct: 119 VEIAFFSRWWHQQ-TNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLR 177
Query: 146 WLLDNLGYV--PKNAWSIDPFGYSSAQPYLLKIAGFDNSMIQRVHYRIKKELASNRQLEF 203
+L D G P+ AW IDPFG+S Q L GFD R+ Y+ K ++E
Sbjct: 178 FLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQ 237
Query: 204 RWRQLWDGVGKT-DMFTHLFPFYSYDVPHSCGPDPKICCQFDFKRLPGNGVTCPWGVAPQ 262
WR T D+FT + P Y+ P + D + C V P V
Sbjct: 238 VWRASTSLKPPTADLFTGVLP-NGYNPPRNLCWD--VLC-----------VDQPL-VEDP 282
Query: 263 RITQKNVDERAFKILDQWRKKAQLYRSNVLFFPLGDDFRYDHANEWDNQYQNYDMLIEYI 322
R + N E L+ + + YR+N +G DF+Y++AN W ++N D LI +
Sbjct: 283 RSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQYENANMW---FKNLDKLIRLV 339
Query: 323 NSNDAWNTEVQ--YGTLEDYFKALHDEVKLSNFPVLSGDFFTYADRNQHYWSGYYTSRPF 380
N+ A + V Y T Y L+ + L+ + V DFF YAD +W+GY++SRP
Sbjct: 340 NAQQAKGSSVHVLYSTPACYLWELN-KANLT-WSVKHDDFFPYADGPHQFWTGYFSSRPA 397
Query: 381 YKNMDRVLLAYVRAAEIITAQATDTHAVSYIMSLQLRDRVEQARRSLSLFQHHDGITGTS 440
K +R+ +++ + A V S ++++ QHHD ++GTS
Sbjct: 398 LKRYERLSYNFLQVCNQLEALVGLAANVGPYGS----GDSAPLNEAMAVLQHHDAVSGTS 453
Query: 441 RDEVREDYAKKM 452
R V DYA+++
Sbjct: 454 RQHVANDYARQL 465
Score = 77.4 bits (182), Expect = 2e-13
Identities = 68/229 (29%), Positives = 108/229 (47%), Gaps = 24/229 (10%)
Query: 649 GLVKTIVSRDG-VATPVHMDFVQYDTQKG---RDNNSGAYLFIPSGPAKDFKSDPYPEIV 704
GL+ I++ + + PV F Y+ G D SGAY+F P+ K + +I
Sbjct: 621 GLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAYIFRPN-QQKPLPVSRWAQIH 679
Query: 705 VTEGIHKSTLYAALVGPKTAEIILSVTVYNNPSLPHAELEVSSALLIDPQVDDLELALRL 764
+ K+ L + +A V +Y P H ELE S + E+ R
Sbjct: 680 LV----KTPLVQEVHQNFSAWCSQVVRLY--PGQRHLELEWSVGPIPVGDTWGKEVISRF 733
Query: 765 STSVRNGDVFYTDLNGMQMIKRR--------YFEKIPLQANFYPLPAAAYIEDENIRFTV 816
T + FYTD NG ++++RR + P+ N+YP+ YI D N++ TV
Sbjct: 734 DTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTV 793
Query: 817 LTSTPLGMAALQPGQIEVMQDRRLSRDDNRGMNQGVLDN-----VRTRH 860
LT G ++L+ G +E+M RRL +DD RG+++ +++N VR RH
Sbjct: 794 LTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVRGRH 842
>U05572-1|AAB03816.1| 987|Homo sapiens alpha-mannosidase protein.
Length = 987
Score = 193 bits (470), Expect = 3e-48
Identities = 134/431 (31%), Positives = 210/431 (48%), Gaps = 37/431 (8%)
Query: 34 QKNKLKVFIVPHSHNDPGWLKTFENYY--------KSQTRAIFNNMIEKLNEGVGRKFIW 85
Q N L V ++PH+H+D GWLKT + Y+ + + I +++I L R+FI+
Sbjct: 36 QPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIY 95
Query: 86 AEISFLSLWWNNDATEKDKTAFLNLLKSKKLEIVTGGWVMNDEANSHWLSVVQQLTTGHQ 145
EI+F S WW+ T + +L++ +LE GGWVMNDEA +H+ ++V Q+T G +
Sbjct: 96 VEIAFFSRWWHQQ-TNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLR 154
Query: 146 WLLDNLGYV--PKNAWSIDPFGYSSAQPYLLKIAGFDNSMIQRVHYRIKKELASNRQLEF 203
+L D G P+ AW IDPFG+S Q L GFD R+ Y+ K ++E
Sbjct: 155 FLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQ 214
Query: 204 RWRQLWDGVGKT-DMFTHLFPFYSYDVPHSCGPDPKICCQFDFKRLPGNGVTCPWGVAPQ 262
WR T D+FT + P Y+ P + D + C V P V
Sbjct: 215 VWRASTSLKPPTADLFTGVLP-NGYNPPRNLCWD--VLC-----------VDQPL-VEDP 259
Query: 263 RITQKNVDERAFKILDQWRKKAQLYRSNVLFFPLGDDFRYDHANEWDNQYQNYDMLIEYI 322
R + N E L+ + + YR+N +G DF+Y++AN W ++N D LI +
Sbjct: 260 RSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQYENANMW---FKNLDKLIRLV 316
Query: 323 NSNDAWNT-EVQYGTLEDYFKALHDEVKLSNFPVLSGDFFTYADRNQHYWSGYYTSRPFY 381
N+ ++ V Y T Y L+ + L+ + V DFF YAD +W+GY++SRP
Sbjct: 317 NAQAKGSSVHVLYSTPACYLWELN-KANLT-WSVKHDDFFPYADGPHQFWTGYFSSRPAL 374
Query: 382 KNMDRVLLAYVRAAEIITAQATDTHAVSYIMSLQLRDRVEQARRSLSLFQHHDGITGTSR 441
K +R+ +++ + A V S ++++ QHHD ++GTSR
Sbjct: 375 KRYERLSYNFLQVCNQLEALVGLAANVGPYGS----GDSAPLNEAMAVLQHHDAVSGTSR 430
Query: 442 DEVREDYAKKM 452
V DYA+++
Sbjct: 431 QHVANDYARQL 441
Score = 77.4 bits (182), Expect = 2e-13
Identities = 68/229 (29%), Positives = 108/229 (47%), Gaps = 24/229 (10%)
Query: 649 GLVKTIVSRDG-VATPVHMDFVQYDTQKG---RDNNSGAYLFIPSGPAKDFKSDPYPEIV 704
GL+ I++ + + PV F Y+ G D SGAY+F P+ K + +I
Sbjct: 597 GLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAYIFRPN-QQKPLPVSRWAQIH 655
Query: 705 VTEGIHKSTLYAALVGPKTAEIILSVTVYNNPSLPHAELEVSSALLIDPQVDDLELALRL 764
+ K+ L + +A V +Y P H ELE S + E+ R
Sbjct: 656 LV----KTPLVQEVHQNFSAWCSQVVRLY--PGQRHLELEWSVGPIPVGDTWGKEVISRF 709
Query: 765 STSVRNGDVFYTDLNGMQMIKRR--------YFEKIPLQANFYPLPAAAYIEDENIRFTV 816
T + FYTD NG ++++RR + P+ N+YP+ YI D N++ TV
Sbjct: 710 DTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTV 769
Query: 817 LTSTPLGMAALQPGQIEVMQDRRLSRDDNRGMNQGVLDN-----VRTRH 860
LT G ++L+ G +E+M RRL +DD RG+++ +++N VR RH
Sbjct: 770 LTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVRGRH 818
>U68382-1|AAC50811.1| 323|Homo sapiens truncated lysosomal acid
alpha-mannosidase protein.
Length = 323
Score = 147 bits (357), Expect = 2e-34
Identities = 99/302 (32%), Positives = 150/302 (49%), Gaps = 30/302 (9%)
Query: 34 QKNKLKVFIVPHSHNDPGWLKTFENYY--------KSQTRAIFNNMIEKLNEGVGRKFIW 85
Q N L V ++PH+H+D GWLKT + Y+ + + I +++I L E R+FI+
Sbjct: 36 QPNMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLEDPTRRFIY 95
Query: 86 AEISFLSLWWNNDATEKDKTAFLNLLKSKKLEIVTGGWVMNDEANSHWLSVVQQLTTGHQ 145
EI+F S WW+ T + +L++ +LE GGWVMNDEA +H+ ++V Q+T G +
Sbjct: 96 VEIAFFSRWWHQQ-TNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLR 154
Query: 146 WLLDNLGYV--PKNAWSIDPFGYSSAQPYLLKIAGFDNSMIQRVHYRIKKELASNRQLEF 203
+L D G P+ AW IDPFG+S Q L GFD R+ Y+ K ++E
Sbjct: 155 FLEDTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQ 214
Query: 204 RWRQLWDGVGKT-DMFTHLFPFYSYDVPHSCGPDPKICCQFDFKRLPGNGVTCPWGVAPQ 262
WR T D+FT + P Y+ P + D + C V P V
Sbjct: 215 VWRASTSLKPPTADLFTGVLP-NGYNPPRNLCWD--VLC-----------VDQPL-VEDP 259
Query: 263 RITQKNVDERAFKILDQWRKKAQLYRSNVLFFPLGDDFRYDHANEWDNQYQNYDMLIEYI 322
R + N E L+ + + YR+N +G DF+Y++AN W ++N D LI +
Sbjct: 260 RSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQYENANMW---FKNLDKLIRLV 316
Query: 323 NS 324
N+
Sbjct: 317 NA 318
>BC036836-1|AAH36836.1| 358|Homo sapiens MAN2B2 protein protein.
Length = 358
Score = 60.1 bits (139), Expect = 4e-08
Identities = 31/84 (36%), Positives = 49/84 (58%), Gaps = 2/84 (2%)
Query: 759 ELALRLSTSVRNGDVFYTDLNGMQMIKRRYFEKI--PLQANFYPLPAAAYIEDENIRFTV 816
E LR ST++ + V Y+D NG QM +R Y + + N+YP+ +A++ED R +
Sbjct: 63 EAVLRTSTNLNSQQVIYSDNNGYQMQRRPYVSYVNNSIARNYYPMVQSAFMEDGKSRLVL 122
Query: 817 LTSTPLGMAALQPGQIEVMQDRRL 840
L+ G+++ GQ+EVM RRL
Sbjct: 123 LSERAHGISSQGNGQVEVMLHRRL 146
>BC080191-1|AAH80191.1| 1017|Homo sapiens MAN2C1 protein protein.
Length = 1017
Score = 40.7 bits (91), Expect = 0.026
Identities = 69/329 (20%), Positives = 114/329 (34%), Gaps = 20/329 (6%)
Query: 45 HSHNDPGWLKTFENYYKSQTRAIFNNMIEKLNEGVGRKFIWAEISFLSLWWNNDATEKDK 104
H H D WL F+ + R+ + +L E +FI+A L W
Sbjct: 258 HCHIDTAWLWPFKETVRKCARSWVTAL--QLMER-NPEFIFACSQAQQLEWVKSRYPGLY 314
Query: 105 TAFLNLLKSKKLEIVTGGWVMNDEANSHWLSVVQQLTTGHQWLLDNLGYVPKNAWSIDPF 164
+ + V G WV D ++V+Q G + L G + W D F
Sbjct: 315 SRIQEFACCGQFVPVGGTWVEMDGNLPSGEAMVRQFLQGQNFFLQEFGKMCSEFWLPDTF 374
Query: 165 GYSSAQPYLLKIAGFDNSMIQRVHYRIKKELASNRQLEFRWRQLWDGVGKTDMFTHLFPF 224
GYS+ P ++ G + Q++ + + + W+G+ + + H P
Sbjct: 375 GYSAQLPQIMHGCGIRRFLTQKLSWNLVNSFPHH-------TFFWEGLDGSRVLVHFPPG 427
Query: 225 YSYDVPHSCGPDPK-ICCQFDFKRLPGNGVTCPWGVAPQRITQKNVDERAFKILDQWRKK 283
SY + S K + D R + +G TQ +D +
Sbjct: 428 DSYGMQGSVEEVLKTVANNRDKGRANHSAFLFGFGDGGGGPTQTMLDRLKRLSNTDGLPR 487
Query: 284 AQLYRSNVLFFPLGDDFRYDHANEWDNQYQNYDMLIEYINSNDAWNTEVQYGTLEDYFKA 343
QL LF L D + W ++ +E N + +++ G E +
Sbjct: 488 VQLSSPRQLFSALESD--SEQLCTWVG-----ELFLELHNGTYTTHAQIKKGNRE-CERI 539
Query: 344 LHDEVKLSNFPVLSGDFFTY-ADRNQHYW 371
LHD LS+ + F Y A + QH W
Sbjct: 540 LHDVELLSSLALARSAQFLYPAAQLQHLW 568
>BC050550-1|AAH50550.1| 1040|Homo sapiens mannosidase, alpha, class
2C, member 1 protein.
Length = 1040
Score = 40.7 bits (91), Expect = 0.026
Identities = 69/329 (20%), Positives = 114/329 (34%), Gaps = 20/329 (6%)
Query: 45 HSHNDPGWLKTFENYYKSQTRAIFNNMIEKLNEGVGRKFIWAEISFLSLWWNNDATEKDK 104
H H D WL F+ + R+ + +L E +FI+A L W
Sbjct: 258 HCHIDTAWLWPFKETVRKCARSWVTAL--QLMER-NPEFIFACSQAQQLEWVKSRYPGLY 314
Query: 105 TAFLNLLKSKKLEIVTGGWVMNDEANSHWLSVVQQLTTGHQWLLDNLGYVPKNAWSIDPF 164
+ + V G WV D ++V+Q G + L G + W D F
Sbjct: 315 SRIQEFACRGQFVPVGGTWVEMDGNLPSGEAMVRQFLQGQNFFLQEFGKMCSEFWLPDTF 374
Query: 165 GYSSAQPYLLKIAGFDNSMIQRVHYRIKKELASNRQLEFRWRQLWDGVGKTDMFTHLFPF 224
GYS+ P ++ G + Q++ + + + W+G+ + + H P
Sbjct: 375 GYSAQLPQIMHGCGIRRFLTQKLSWNLVNSFPHH-------TFFWEGLDGSRVLVHFPPG 427
Query: 225 YSYDVPHSCGPDPK-ICCQFDFKRLPGNGVTCPWGVAPQRITQKNVDERAFKILDQWRKK 283
SY + S K + D R + +G TQ +D +
Sbjct: 428 DSYGMQGSVEEVLKTVANNRDKGRANHSAFLFGFGDGGGGPTQTMLDRLKRLSNTDGLPR 487
Query: 284 AQLYRSNVLFFPLGDDFRYDHANEWDNQYQNYDMLIEYINSNDAWNTEVQYGTLEDYFKA 343
QL LF L D + W ++ +E N + +++ G E +
Sbjct: 488 VQLSSPRQLFSALESD--SEQLCTWVG-----ELFLELHNGTYTTHAQIKKGNRE-CERI 539
Query: 344 LHDEVKLSNFPVLSGDFFTY-ADRNQHYW 371
LHD LS+ + F Y A + QH W
Sbjct: 540 LHDVELLSSLALARSAQFLYPAAQLQHLW 568
>AF044414-1|AAC00190.2| 1062|Homo sapiens alpha mannosidase 6A8B
protein.
Length = 1062
Score = 40.7 bits (91), Expect = 0.026
Identities = 69/329 (20%), Positives = 114/329 (34%), Gaps = 20/329 (6%)
Query: 45 HSHNDPGWLKTFENYYKSQTRAIFNNMIEKLNEGVGRKFIWAEISFLSLWWNNDATEKDK 104
H H D WL F+ + R+ + +L E +FI+A L W
Sbjct: 258 HCHIDTAWLWPFKETVRKCARSWVTAL--QLMER-NPEFIFACSQAQQLEWVKSRYPGLY 314
Query: 105 TAFLNLLKSKKLEIVTGGWVMNDEANSHWLSVVQQLTTGHQWLLDNLGYVPKNAWSIDPF 164
+ + V G WV D ++V+Q G + L G + W D F
Sbjct: 315 SRIQEFACRGQFVPVGGTWVEMDGNLPSGEAMVRQFLQGQNFFLQEFGKMCSEFWLPDTF 374
Query: 165 GYSSAQPYLLKIAGFDNSMIQRVHYRIKKELASNRQLEFRWRQLWDGVGKTDMFTHLFPF 224
GYS+ P ++ G + Q++ + + + W+G+ + + H P
Sbjct: 375 GYSAQLPQIMHGCGIRRFLTQKLSWNLVNSFPHH-------TFFWEGLDGSRVLVHFPPG 427
Query: 225 YSYDVPHSCGPDPK-ICCQFDFKRLPGNGVTCPWGVAPQRITQKNVDERAFKILDQWRKK 283
SY + S K + D R + +G TQ +D +
Sbjct: 428 DSYGMQGSVEEVLKTVANNRDKGRANHSAFLFGFGDGGGGPTQTMLDRLKRLSNTDGLPR 487
Query: 284 AQLYRSNVLFFPLGDDFRYDHANEWDNQYQNYDMLIEYINSNDAWNTEVQYGTLEDYFKA 343
QL LF L D + W ++ +E N + +++ G E +
Sbjct: 488 VQLSSPRQLFSALESD--SEQLCTWVG-----ELFLELHNGTYTTHAQIKKGNRE-CERI 539
Query: 344 LHDEVKLSNFPVLSGDFFTY-ADRNQHYW 371
LHD LS+ + F Y A + QH W
Sbjct: 540 LHDVELLSSLALARSAQFLYPAAQLQHLW 568
>BX640905-1|CAE45950.1| 1706|Homo sapiens hypothetical protein
protein.
Length = 1706
Score = 34.7 bits (76), Expect = 1.7
Identities = 22/61 (36%), Positives = 33/61 (54%), Gaps = 5/61 (8%)
Query: 441 RDEVREDYAKKMLTAIKYSQSAIQQAAYYLLKQP----HIQDQTQEDIFLDVDDIWRRHD 496
++E Y KK+ + YS +A Q A YL + P +I +QED+F + DDIW +
Sbjct: 962 KNEEVPGYTKKVGSEWMYSSAAEQLLAEYLERAPELFSYIAKNSQEDVFYE-DDIWPGEN 1020
Query: 497 E 497
E
Sbjct: 1021 E 1021
>AY137776-1|AAN11306.1| 1706|Homo sapiens DNA strand-exchange protein
SEP1 protein.
Length = 1706
Score = 34.7 bits (76), Expect = 1.7
Identities = 22/61 (36%), Positives = 33/61 (54%), Gaps = 5/61 (8%)
Query: 441 RDEVREDYAKKMLTAIKYSQSAIQQAAYYLLKQP----HIQDQTQEDIFLDVDDIWRRHD 496
++E Y KK+ + YS +A Q A YL + P +I +QED+F + DDIW +
Sbjct: 962 KNEEVPGYTKKVGSEWMYSSAAEQLLAEYLERAPELFSYIAKNSQEDVFYE-DDIWPGEN 1020
Query: 497 E 497
E
Sbjct: 1021 E 1021
>AL133623-1|CAB63749.1| 1159|Homo sapiens hypothetical protein
protein.
Length = 1159
Score = 34.7 bits (76), Expect = 1.7
Identities = 22/61 (36%), Positives = 33/61 (54%), Gaps = 5/61 (8%)
Query: 441 RDEVREDYAKKMLTAIKYSQSAIQQAAYYLLKQP----HIQDQTQEDIFLDVDDIWRRHD 496
++E Y KK+ + YS +A Q A YL + P +I +QED+F + DDIW +
Sbjct: 427 KNEEVPGYTKKVGSEWMYSSAAEQLLAEYLERAPELFSYIAKNSQEDVFYE-DDIWPGEN 485
Query: 497 E 497
E
Sbjct: 486 E 486
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.320 0.135 0.413
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 154,953,237
Number of Sequences: 224733
Number of extensions: 6845653
Number of successful extensions: 10719
Number of sequences better than 10.0: 22
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 10580
Number of HSP's gapped (non-prelim): 48
length of query: 1027
length of database: 73,234,838
effective HSP length: 97
effective length of query: 930
effective length of database: 51,435,737
effective search space: 47835235410
effective search space used: 47835235410
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 70 (32.3 bits)
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