Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA004872-TA|BGIBMGA004872-PA|IPR011009|Protein
kinase-like, IPR006575|RWD, IPR000719|Protein kinase,
IPR008271|Serine/threonine protein kinase, active site,
IPR008266|Tyrosine protein kinase, active site, IPR001245|Tyrosine
protein kinase, IPR002290|Serine/threonine protein kinase
(1564 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AB037759-1|BAA92576.1| 1495|Homo sapiens KIAA1338 protein protein. 594 e-169
AL157497-1|CAB75678.1| 938|Homo sapiens hypothetical protein pr... 440 e-122
BC009350-1|AAH09350.2| 829|Homo sapiens EIF2AK4 protein protein. 401 e-111
AK027011-1|BAB15625.1| 806|Homo sapiens protein ( Homo sapiens ... 369 e-101
BC078179-1|AAH78179.1| 616|Homo sapiens EIF2AK4 protein protein. 222 9e-57
AJ243428-1|CAB58360.1| 548|Homo sapiens putative eIF2 alpha kin... 172 7e-42
U50648-1|AAC50768.1| 551|Homo sapiens interferon-inducible RNA-... 113 6e-24
M85294-1|AAA18253.1| 551|Homo sapiens P1/eIF-2a protein kinase ... 113 6e-24
M35663-1|AAA36409.1| 551|Homo sapiens protein ( Human p68 kinas... 113 6e-24
BC126356-1|AAI26357.1| 1115|Homo sapiens eukaryotic translation ... 113 6e-24
BC126354-1|AAI26355.1| 1116|Homo sapiens eukaryotic translation ... 113 6e-24
BC101475-1|AAI01476.1| 551|Homo sapiens eukaryotic translation ... 113 6e-24
BC093676-1|AAH93676.1| 551|Homo sapiens eukaryotic translation ... 113 6e-24
AY302136-1|AAP57628.1| 510|Homo sapiens interferon-inducible do... 113 6e-24
AY228338-1|AAO38055.1| 551|Homo sapiens protein kinase, interfe... 113 6e-24
AF284615-1|AAF91480.1| 1115|Homo sapiens initiation factor 2-alp... 113 6e-24
AF193339-1|AAF61199.1| 1115|Homo sapiens eukaryotic translation ... 113 6e-24
AF110146-1|AAD19961.1| 1115|Homo sapiens eukaryotic translation ... 113 6e-24
AC104134-2|AAY24331.1| 970|Homo sapiens unknown protein. 113 6e-24
AC007899-1|AAY24317.1| 551|Homo sapiens unknown protein. 113 6e-24
AK075192-1|BAC11461.1| 630|Homo sapiens protein ( Homo sapiens ... 111 3e-23
BC006524-1|AAH06524.1| 630|Homo sapiens eukaryotic translation ... 110 3e-23
AF255050-1|AAF70289.1| 629|Homo sapiens heme-regulated eukaryot... 110 3e-23
AF183414-1|AAG09683.1| 630|Homo sapiens hemin-sensitive initiat... 110 3e-23
AF181071-1|AAF18391.1| 630|Homo sapiens heme-regulated initiati... 110 3e-23
AF147094-1|AAF66736.1| 629|Homo sapiens heme-regulated initiati... 110 3e-23
AF100784-1|AAP97223.1| 630|Homo sapiens hemin-sensitive initita... 110 3e-23
AC005995-1|AAS00388.1| 386|Homo sapiens unknown protein. 110 3e-23
AB037790-1|BAA92607.1| 653|Homo sapiens KIAA1369 protein protein. 110 3e-23
AF167472-1|AAF13156.1| 551|Homo sapiens double stranded RNA act... 109 8e-23
BC057805-1|AAH57805.1| 513|Homo sapiens EIF2AK2 protein protein. 105 1e-21
BC040851-1|AAH40851.1| 513|Homo sapiens EIF2AK2 protein protein. 105 1e-21
U50062-1|AAC32232.1| 671|Homo sapiens RIP protein kinase protein. 89 1e-16
BC126256-1|AAI26257.1| 671|Homo sapiens receptor (TNFRSF)-inter... 89 1e-16
BC126254-1|AAI26255.1| 671|Homo sapiens receptor (TNFRSF)-inter... 89 1e-16
AY682848-1|AAT74626.1| 671|Homo sapiens receptor (TNFRSF)-inter... 89 1e-16
AL031963-3|CAD70625.1| 671|Homo sapiens receptor (TNFRSF)-inter... 89 1e-16
D86968-1|BAA13204.2| 1626|Homo sapiens KIAA0213 protein. 88 3e-16
AL596452-3|CAI41309.1| 1498|Homo sapiens mitogen-activated prote... 88 3e-16
AL596452-2|CAI41310.1| 1544|Homo sapiens mitogen-activated prote... 88 3e-16
AL591045-2|CAH70639.1| 1498|Homo sapiens mitogen-activated prote... 88 3e-16
AL591045-1|CAH70640.1| 1544|Homo sapiens mitogen-activated prote... 88 3e-16
AL139393-2|CAI20815.1| 1498|Homo sapiens mitogen-activated prote... 88 3e-16
AL139393-1|CAI20816.1| 1544|Homo sapiens mitogen-activated prote... 88 3e-16
AL109942-4|CAI21477.1| 1498|Homo sapiens mitogen-activated prote... 88 3e-16
AL109942-3|CAC12766.2| 1544|Homo sapiens mitogen-activated prote... 88 3e-16
AF002715-1|AAB68804.1| 1607|Homo sapiens MAP kinase kinase kinas... 88 3e-16
AC004895-3|AAS00356.1| 243|Homo sapiens unknown protein. 83 6e-15
BC112101-1|AAI12102.1| 979|Homo sapiens NIMA related kinase 9 p... 83 8e-15
BC093881-1|AAH93881.1| 979|Homo sapiens NIMA (never in mitosis ... 83 8e-15
AY080896-1|AAL87410.1| 979|Homo sapiens NIMA-family kinase NERC... 83 8e-15
AY048580-1|AAL05428.1| 979|Homo sapiens NIMA-related kinase Nek... 83 8e-15
AC007055-5|AAD31940.1| 312|Homo sapiens protein ( Homo sapiens ... 83 8e-15
AB082526-1|BAC02704.1| 1011|Homo sapiens KIAA1995 protein protein. 83 8e-15
AK131198-1|BAD18393.1| 706|Homo sapiens protein ( Homo sapiens ... 81 3e-14
L19559-1|AAA36659.1| 603|Homo sapiens protein kinase protein. 79 9e-14
X75932-1|CAA53536.1| 603|Homo sapiens Serine/Threonine protein ... 79 1e-13
X73458-1|CAA51837.1| 603|Homo sapiens protein kinase protein. 79 2e-13
U01038-1|AAA56634.1| 603|Homo sapiens pLK protein. 79 2e-13
BC014846-1|AAH14846.1| 603|Homo sapiens polo-like kinase 1 (Dro... 79 2e-13
BC003002-1|AAH03002.1| 603|Homo sapiens polo-like kinase 1 (Dro... 79 2e-13
BC002369-1|AAH02369.1| 603|Homo sapiens polo-like kinase 1 (Dro... 79 2e-13
BC017575-1|AAH17575.1| 476|Homo sapiens CHK1 checkpoint homolog... 78 2e-13
BC004202-1|AAH04202.1| 476|Homo sapiens CHEK1 protein protein. 78 2e-13
AF527555-1|AAM78553.1| 476|Homo sapiens CHK1 checkpoint homolog... 78 2e-13
AF032874-1|AAB88852.1| 476|Homo sapiens protein kinase protein. 78 2e-13
AF016582-1|AAC51736.1| 476|Homo sapiens Chk1 protein. 78 2e-13
AB032387-1|BAA84577.1| 476|Homo sapiens checkpoint kinase protein. 78 2e-13
BC099843-1|AAH99843.1| 416|Homo sapiens serine/threonine protei... 77 4e-13
Z11518-1|CAA77607.1| 509|Homo sapiens histidyl-tRNA synthetase ... 77 7e-13
BC080514-1|AAH80514.1| 509|Homo sapiens histidyl-tRNA synthetas... 77 7e-13
BC011807-1|AAH11807.1| 509|Homo sapiens histidyl-tRNA synthetas... 77 7e-13
BT020099-1|AAV38902.1| 416|Homo sapiens Mst3 and SOK1-related k... 76 1e-12
BC103503-1|AAI03504.1| 416|Homo sapiens serine/threonine protei... 76 1e-12
BC098315-1|AAH98315.1| 416|Homo sapiens serine/threonine protei... 76 1e-12
AL109749-1|CAI42079.1| 416|Homo sapiens Mst3 and SOK1-related k... 76 1e-12
AK075150-1|BAC11435.1| 392|Homo sapiens protein ( Homo sapiens ... 76 1e-12
AK075107-1|BAC11406.1| 339|Homo sapiens protein ( Homo sapiens ... 76 1e-12
AF344882-1|AAK29620.1| 416|Homo sapiens serine/threonine protei... 76 1e-12
AF231012-1|AAK38484.1| 416|Homo sapiens STE20-like kinase MST4 ... 76 1e-12
AB040057-1|BAA92785.2| 416|Homo sapiens serine/threonine protei... 76 1e-12
U56816-1|AAC50949.1| 499|Homo sapiens kinase Myt1 protein. 75 2e-12
BC130011-1|AAI30012.1| 485|Homo sapiens PKMYT1 protein protein. 75 2e-12
BC121162-1|AAI21163.1| 485|Homo sapiens PKMYT1 protein protein. 75 2e-12
BC121161-1|AAI21162.1| 485|Homo sapiens PKMYT1 protein protein. 75 2e-12
AF549406-1|AAN40703.1| 499|Homo sapiens membrane-associated tyr... 75 2e-12
AF014118-1|AAB71843.1| 499|Homo sapiens membrane-associated kin... 75 2e-12
AC004235-1|AAC04477.1| 495|Homo sapiens Myt1 protein. 75 2e-12
AC004233-1|AAC04478.1| 499|Homo sapiens Myt1 protein. 75 2e-12
AB209179-1|BAD92416.1| 546|Homo sapiens polo-like kinase varian... 75 2e-12
BC026060-1|AAH26060.1| 541|Homo sapiens calcium/calmodulin-depe... 75 2e-12
BC000318-1|AAH00318.2| 266|Homo sapiens CAMKK2 protein protein. 75 2e-12
AY995220-1|AAX99363.1| 509|Homo sapiens histidyl-tRNA synthetas... 75 2e-12
AL834322-1|CAD38990.1| 365|Homo sapiens hypothetical protein pr... 75 2e-12
AF321402-1|AAK91829.1| 588|Homo sapiens Ca2+/calmodulin-depende... 75 2e-12
AF321401-1|AAK91830.1| 533|Homo sapiens Ca2+/calmodulin-depende... 75 2e-12
AF321388-1|AAL37218.1| 498|Homo sapiens CaMKK beta 1 isoform pr... 75 2e-12
AF321387-1|AAL37217.1| 541|Homo sapiens CaMKK beta 1 isoform pr... 75 2e-12
AF321386-1|AAL37216.1| 545|Homo sapiens CaMKK beta 1 isoform pr... 75 2e-12
AF321385-1|AAL37215.1| 490|Homo sapiens CaMKK beta 2 isoform pr... 75 2e-12
AF287631-1|AAK64601.1| 533|Homo sapiens calcium/calmodulin-depe... 75 2e-12
AF287630-1|AAK64600.1| 588|Homo sapiens calcium/calmodulin-depe... 75 2e-12
AF101264-1|AAD04566.1| 417|Homo sapiens Ca2+/calmodulin-depende... 75 2e-12
AB081337-1|BAC19841.1| 498|Homo sapiens Ca2+/calmodulin-depende... 75 2e-12
AB081336-1|BAC19840.1| 541|Homo sapiens Ca2+/calmodulin-depende... 75 2e-12
AB018330-1|BAA34507.2| 557|Homo sapiens KIAA0787 protein protein. 75 2e-12
BT019619-1|AAV38425.1| 431|Homo sapiens serine/threonine kinase... 75 3e-12
BC071579-1|AAH71579.1| 873|Homo sapiens MAP4K3 protein protein. 75 3e-12
BC065378-1|AAH65378.1| 431|Homo sapiens serine/threonine kinase... 75 3e-12
BC063885-1|AAH63885.1| 708|Homo sapiens NIMA (never in mitosis ... 75 3e-12
BC035578-1|AAH35578.1| 431|Homo sapiens serine/threonine kinase... 75 3e-12
BC031231-1|AAH31231.1| 514|Homo sapiens serine/threonine kinase... 75 3e-12
AL356423-3|CAI13115.1| 431|Homo sapiens serine/threonine kinase... 75 3e-12
AL356423-2|CAI13114.1| 443|Homo sapiens serine/threonine kinase... 75 3e-12
AL139082-5|CAI12892.2| 708|Homo sapiens NIMA (never in mitosis ... 75 3e-12
AL137249-7|CAI39457.1| 431|Homo sapiens serine/threonine kinase... 75 3e-12
AL137249-3|CAI39453.1| 443|Homo sapiens serine/threonine kinase... 75 3e-12
AK093251-1|BAC04109.1| 514|Homo sapiens protein ( Homo sapiens ... 75 3e-12
AJ303380-1|CAC29064.1| 514|Homo sapiens serine/threonine kinase... 75 3e-12
AF445413-2|AAN75850.1| 873|Homo sapiens MAP4K3 protein. 75 3e-12
AF445413-1|AAN75849.1| 894|Homo sapiens MAP4K3 protein. 75 3e-12
AF083420-1|AAD42039.1| 443|Homo sapiens brain-specific STE20-li... 75 3e-12
AF024636-1|AAB82560.1| 431|Homo sapiens STE20-like kinase 3 pro... 75 3e-12
AF000145-1|AAC15472.1| 884|Homo sapiens germinal center kinase ... 75 3e-12
AC007684-1|AAF19240.1| 712|Homo sapiens unknown protein. 75 3e-12
U63973-1|AAB05929.1| 563|Homo sapiens rhodopsin kinase protein. 74 4e-12
L77503-1|AAG50439.1| 563|Homo sapiens rhodopsin kinase protein. 74 4e-12
L77502-1|AAT00534.2| 563|Homo sapiens rhodopsin kinase protein. 74 4e-12
AJ271722-1|CAB71146.1| 714|Homo sapiens putative serine/threoni... 74 4e-12
U18937-1|AAA73974.1| 506|Homo sapiens histidyl-tRNA synthetase ... 74 5e-12
BC047865-1|AAH47865.1| 812|Homo sapiens MAP4K2 protein protein. 74 5e-12
BC014982-1|AAH14982.1| 506|Homo sapiens histidyl-tRNA synthetas... 74 5e-12
BC007680-1|AAH07680.1| 506|Homo sapiens histidyl-tRNA synthetas... 74 5e-12
AL356423-1|CAI13113.1| 368|Homo sapiens serine/threonine kinase... 74 5e-12
AL137249-2|CAI39452.1| 368|Homo sapiens serine/threonine kinase... 74 5e-12
AF140507-1|AAD31507.1| 588|Homo sapiens Ca2+/calmodulin-depende... 74 5e-12
U07349-1|AAA20968.1| 819|Homo sapiens GC kinase protein. 73 8e-12
M60725-1|AAA36411.1| 502|Homo sapiens p70 ribosomal S6 kinase a... 73 8e-12
M60724-1|AAA36410.1| 525|Homo sapiens p70 ribosomal S6 kinase a... 73 8e-12
BC053365-1|AAH53365.1| 451|Homo sapiens RPS6KB1 protein protein. 73 8e-12
U56998-1|AAC50637.1| 607|Homo sapiens putative serine/threonine... 73 1e-11
BC013899-1|AAH13899.1| 646|Homo sapiens polo-like kinase 3 (Dro... 73 1e-11
AY764184-1|AAU88146.1| 646|Homo sapiens polo-like kinase 3 (Dro... 73 1e-11
AL592166-11|CAI13006.1| 646|Homo sapiens polo-like kinase 3 (Dr... 73 1e-11
AJ293866-1|CAC10659.1| 646|Homo sapiens FNK serine/threonine pr... 73 1e-11
AB209875-1|BAD93112.1| 621|Homo sapiens polo-like kinase 3 vari... 73 1e-11
X99325-1|CAA67700.1| 426|Homo sapiens Ste20-like kinase protein. 72 1e-11
D63780-1|BAA20420.1| 426|Homo sapiens YSK1 protein. 72 1e-11
DQ093965-1|AAY88740.1| 426|Homo sapiens serine/threonine kinase... 72 1e-11
CR542227-1|CAG47023.1| 431|Homo sapiens STK24 protein. 72 1e-11
BT019961-1|AAV38764.1| 426|Homo sapiens serine/threonine kinase... 72 1e-11
BC114491-1|AAI14492.1| 1189|Homo sapiens NEK1 protein protein. 72 1e-11
BC091505-1|AAH91505.1| 426|Homo sapiens STK25 protein protein. 72 1e-11
BC015793-1|AAH15793.1| 426|Homo sapiens STK25 protein protein. 72 1e-11
BC015147-1|AAH15147.1| 403|Homo sapiens Unknown (protein for IM... 72 1e-11
BC007852-1|AAH07852.1| 426|Homo sapiens serine/threonine kinase... 72 1e-11
AF030403-1|AAD01901.1| 547|Homo sapiens Ste20-like protein kina... 72 1e-11
AC110299-2|AAY14683.1| 426|Homo sapiens unknown protein. 72 1e-11
AB067488-1|BAB67794.1| 1265|Homo sapiens KIAA1901 protein protein. 72 1e-11
Z11694-1|CAA77752.1| 360|Homo sapiens 41kD protein kinase protein. 72 2e-11
X69117-1|CAA48870.1| 688|Homo sapiens beta-adrenergic kinase 2 ... 71 3e-11
M95712-1|AAA35609.2| 766|Homo sapiens B-raf protein protein. 71 3e-11
M21001-1|AAA96495.1| 328|Homo sapiens B-raf protein protein. 71 3e-11
BC112079-1|AAI12080.1| 766|Homo sapiens v-raf murine sarcoma vi... 71 3e-11
BC101757-1|AAI01758.1| 766|Homo sapiens v-raf murine sarcoma vi... 71 3e-11
AY803272-1|AAW30454.1| 1492|Homo sapiens AKAP9-BRAF fusion prote... 71 3e-11
AC006344-3|AAD43193.1| 651|Homo sapiens WUGSC:H_DJ0726N20.3 pro... 71 3e-11
Z11695-1|CAA77753.1| 348|Homo sapiens 40kDa protein kinase prot... 71 3e-11
M84489-1|AAA58459.1| 360|Homo sapiens protein kinase 2 protein. 71 3e-11
DQ508104-1|ABF47102.1| 360|Homo sapiens mitogen-activated prote... 71 3e-11
BC017832-1|AAH17832.1| 360|Homo sapiens mitogen-activated prote... 71 3e-11
AF172271-1|AAF03789.1| 1268|Homo sapiens Traf2 and NCK interacti... 71 3e-11
AF172270-1|AAF03788.1| 1297|Homo sapiens Traf2 and NCK interacti... 71 3e-11
AF172269-1|AAF03787.1| 1323|Homo sapiens Traf2 and NCK interacti... 71 3e-11
AF172268-1|AAF03786.1| 1276|Homo sapiens Traf2 and NCK interacti... 71 3e-11
AF172267-1|AAF03785.1| 1352|Homo sapiens Traf2 and NCK interacti... 71 3e-11
AF172266-1|AAF03784.1| 1305|Homo sapiens Traf2 and NCK interacti... 71 3e-11
AF172265-1|AAF03783.1| 1331|Homo sapiens Traf2 and NCK interacti... 71 3e-11
AF172264-1|AAF03782.1| 1360|Homo sapiens Traf2 and NCK interacti... 71 3e-11
AB011123-1|BAA25477.2| 1385|Homo sapiens KIAA0551 protein protein. 71 3e-11
U77129-1|AAB48435.1| 846|Homo sapiens KHS1 protein. 71 4e-11
BC070077-1|AAH70077.1| 968|Homo sapiens serine/threonine kinase... 71 4e-11
BC036013-1|AAH36013.1| 846|Homo sapiens mitogen-activated prote... 71 4e-11
AK000556-1|BAA91251.1| 293|Homo sapiens protein ( Homo sapiens ... 71 4e-11
AB015718-1|BAA35073.1| 968|Homo sapiens protein kinase protein. 71 4e-11
U64205-1|AAC15093.1| 729|Homo sapiens Cdc25C associated protein... 70 6e-11
L07861-1|AAA03175.1| 676|Homo sapiens protein kinase C-delta 13... 70 6e-11
L07860-1|AAA03176.1| 676|Homo sapiens protein kinase C-delta 13... 70 6e-11
D10495-1|BAA01381.1| 626|Homo sapiens protein kinase C delta-ty... 70 6e-11
BC043350-1|AAH43350.1| 676|Homo sapiens protein kinase C, delta... 70 6e-11
BC024773-1|AAH24773.1| 729|Homo sapiens MAP/microtubule affinit... 70 6e-11
AL022329-1|CAB45657.1| 688|Homo sapiens adrenergic, beta, recep... 70 6e-11
AK098832-1|BAC05427.1| 404|Homo sapiens protein ( Homo sapiens ... 70 6e-11
AF387637-1|AAK82367.1| 744|Homo sapiens Ser/Thr protein kinase ... 70 6e-11
X61157-1|CAA43470.1| 689|Homo sapiens beta-adrenergic receptor ... 70 8e-11
X59727-1|CAA42411.1| 557|Homo sapiens 63kDa protein kinase prot... 70 8e-11
U08438-1|AAB60689.1| 689|Homo sapiens beta-adrenergic receptor ... 70 8e-11
M80776-1|AAA58391.1| 689|Homo sapiens receptor kinase protein. 70 8e-11
M80359-1|AAA59991.1| 713|Homo sapiens protein p78 protein. 70 8e-11
BC117216-1|AAI17217.1| 587|Homo sapiens mitogen-activated prote... 70 8e-11
BC090863-1|AAH90863.1| 689|Homo sapiens ADRBK1 protein protein. 70 8e-11
BC050299-1|AAH50299.1| 587|Homo sapiens mitogen-activated prote... 70 8e-11
BC037963-1|AAH37963.1| 689|Homo sapiens adrenergic, beta, recep... 70 8e-11
AY120867-1|AAM55491.1| 752|Homo sapiens MAP/microtubule affinit... 70 8e-11
AY057448-1|AAL23683.1| 752|Homo sapiens MARK4 serine/threonine ... 70 8e-11
AK075272-1|BAC11510.1| 752|Homo sapiens protein ( Homo sapiens ... 70 8e-11
AF465413-1|AAL69982.1| 753|Homo sapiens MAP/microtubule affinit... 70 8e-11
AF099989-1|AAC72238.1| 547|Homo sapiens Ste-20 related kinase S... 70 8e-11
AC067940-1|AAY24032.1| 363|Homo sapiens unknown protein. 70 8e-11
AB088047-1|BAC03375.1| 752|Homo sapiens microtubule affinity-re... 70 8e-11
AB058763-1|BAB47489.1| 689|Homo sapiens KIAA1860 protein protein. 70 8e-11
AB049127-1|BAB39380.1| 688|Homo sapiens MAP/microtubule affinit... 70 8e-11
Y15056-1|CAA75341.1| 556|Homo sapiens PkB kinase protein. 69 1e-10
U59305-1|AAB37126.1| 496|Homo sapiens ser-thr protein kinase PK... 69 1e-10
L07032-1|AAA60101.1| 706|Homo sapiens protein kinase C-theta pr... 69 1e-10
L01087-1|AAA75571.1| 706|Homo sapiens protein kinase C-theta pr... 69 1e-10
CR536517-1|CAG38755.1| 556|Homo sapiens PDPK1 protein. 69 1e-10
BC113359-1|AAI13360.1| 706|Homo sapiens protein kinase C, theta... 69 1e-10
BC101465-1|AAI01466.1| 706|Homo sapiens protein kinase C, theta... 69 1e-10
BC099905-1|AAH99905.1| 360|Homo sapiens mitogen-activated prote... 69 1e-10
BC012103-1|AAH12103.1| 556|Homo sapiens 3-phosphoinositide depe... 69 1e-10
AL627308-5|CAH71336.1| 1732|Homo sapiens CDC42 binding protein k... 69 1e-10
AL627308-4|CAH71338.1| 1638|Homo sapiens CDC42 binding protein k... 69 1e-10
AL627308-3|CAH71337.1| 1719|Homo sapiens CDC42 binding protein k... 69 1e-10
AL451047-3|CAH71185.1| 1732|Homo sapiens CDC42 binding protein k... 69 1e-10
AL451047-2|CAH71184.1| 1638|Homo sapiens CDC42 binding protein k... 69 1e-10
AL451047-1|CAH71183.1| 1719|Homo sapiens CDC42 binding protein k... 69 1e-10
AL353689-9|CAI19109.1| 1732|Homo sapiens CDC42 binding protein k... 69 1e-10
AL353689-8|CAI19110.1| 1638|Homo sapiens CDC42 binding protein k... 69 1e-10
AL353689-7|CAI19108.1| 1719|Homo sapiens CDC42 binding protein k... 69 1e-10
AL158043-2|CAC12904.2| 706|Homo sapiens protein kinase C, theta... 69 1e-10
AL158043-1|CAI16127.1| 478|Homo sapiens protein kinase C, theta... 69 1e-10
AL137145-2|CAC10200.2| 706|Homo sapiens protein kinase C, theta... 69 1e-10
AL137145-1|CAI15756.1| 478|Homo sapiens protein kinase C, theta... 69 1e-10
AJ518976-1|CAD57746.1| 1638|Homo sapiens CDC42 binding protein k... 69 1e-10
AJ518975-1|CAD57745.1| 1719|Homo sapiens CDC42 binding protein k... 69 1e-10
AF017995-1|AAC51825.1| 556|Homo sapiens 3-phosphoinositide depe... 69 1e-10
AC005591-1|AAC33797.1| 367|Homo sapiens PkB-like protein. 69 1e-10
AB209835-1|BAD93072.1| 492|Homo sapiens 3-phosphoinositide depe... 69 1e-10
AB208968-1|BAD92205.1| 1702|Homo sapiens CDC42 binding protein k... 69 1e-10
L41816-1|AAA99458.1| 370|Homo sapiens cam kinase I protein. 69 1e-10
BC106755-1|AAI06756.1| 370|Homo sapiens calcium/calmodulin-depe... 69 1e-10
BC106754-1|AAI06755.1| 370|Homo sapiens calcium/calmodulin-depe... 69 1e-10
BC036797-1|AAH36797.1| 387|Homo sapiens ADRBK2 protein protein. 69 1e-10
AY166586-1|AAN86031.1| 1638|Homo sapiens CDC42-binding protein k... 69 2e-10
U29727-1|AAA82933.1| 816|Homo sapiens BMK1 gamma kinase protein. 68 2e-10
U29726-1|AAA82932.1| 816|Homo sapiens BMK1 beta kinase protein. 68 2e-10
U29725-1|AAA82931.1| 816|Homo sapiens BMK1 alpha kinase protein. 68 2e-10
U25278-1|AAA81381.1| 815|Homo sapiens ERK5 protein. 68 2e-10
DQ201638-1|ABA27097.1| 527|Homo sapiens oxidative-stress respon... 68 2e-10
BC113705-1|AAI13706.1| 692|Homo sapiens NIMA (never in mitosis ... 68 2e-10
BC112240-1|AAI12241.1| 692|Homo sapiens NIMA-related kinase 8 p... 68 2e-10
BC111088-1|AAI11089.1| 252|Homo sapiens TSSK4 protein protein. 68 2e-10
BC047896-1|AAH47896.1| 524|Homo sapiens RPS6KA4 protein protein. 68 2e-10
BC034673-1|AAH34673.1| 1332|Homo sapiens misshapen-like kinase 1... 68 2e-10
BC030134-1|AAH30134.1| 816|Homo sapiens mitogen-activated prote... 68 2e-10
BC028079-1|AAH28079.1| 556|Homo sapiens Unknown (protein for IM... 68 2e-10
BC009963-1|AAH09963.1| 816|Homo sapiens mitogen-activated prote... 68 2e-10
BC008726-1|AAH08726.1| 527|Homo sapiens oxidative-stress respon... 68 2e-10
AY775058-1|AAV41830.1| 1312|Homo sapiens misshapen/NIKs-related ... 68 2e-10
AY534741-1|AAS38577.1| 533|Homo sapiens mitogen activated prote... 68 2e-10
AY461663-1|AAS17971.1| 328|Homo sapiens testis-specific serine ... 68 2e-10
AY267371-1|AAP04006.1| 692|Homo sapiens NIMA-family kinase NEK8... 68 2e-10
AY242354-1|AAO88243.1| 692|Homo sapiens NIMA-related kinase 12a... 68 2e-10
AK223561-1|BAD97281.1| 765|Homo sapiens ribosomal protein S6 ki... 68 2e-10
AJ010119-1|CAA09009.1| 772|Homo sapiens Ribosomal protein kinas... 68 2e-10
AF074715-1|AAC67395.1| 705|Homo sapiens mitogen- and stress-act... 68 2e-10
AF059681-1|AAC77369.1| 275|Homo sapiens serine/threonine kinase... 68 2e-10
AB041926-1|BAA94838.1| 1303|Homo sapiens GCK family kinase MINK-... 68 2e-10
AB035698-1|BAA90753.1| 1295|Homo sapiens Misshapen/NIK-related k... 68 2e-10
AB029024-1|BAA83053.2| 467|Homo sapiens KIAA1101 protein protein. 68 2e-10
AB017642-1|BAA75674.1| 527|Homo sapiens oxidative-stress respon... 68 2e-10
M55284-1|AAA60100.1| 682|Homo sapiens protein kinase C-L protein. 68 3e-10
BC037268-1|AAH37268.1| 683|Homo sapiens protein kinase C, eta p... 68 3e-10
AY994058-1|AAY44299.1| 254|Homo sapiens extracellular regulated... 68 3e-10
X65293-1|CAA46388.1| 737|Homo sapiens protein kinase C epsilon... 67 4e-10
X03484-1|CAA27204.1| 648|Homo sapiens protein ( Human mRNA for ... 67 4e-10
L00212-1|AAA60247.1| 421|Homo sapiens RAF1 protein. 67 4e-10
BC114478-1|AAI14479.1| 795|Homo sapiens MARK1 protein protein. 67 4e-10
BC113869-1|AAI13870.1| 795|Homo sapiens MARK1 protein protein. 67 4e-10
BC109034-1|AAI09035.1| 737|Homo sapiens protein kinase C, epsil... 67 4e-10
BC109033-1|AAI09034.1| 737|Homo sapiens protein kinase C, epsil... 67 4e-10
BC024179-1|AAH24179.1| 719|Homo sapiens p21(CDKN1A)-activated k... 67 4e-10
BC018119-1|AAH18119.1| 648|Homo sapiens v-raf-1 murine leukemia... 67 4e-10
AY271661-1|AAP03432.1| 648|Homo sapiens v-raf-1 murine leukemia... 67 4e-10
AY065978-1|AAL40897.1| 544|Homo sapiens extracellular signal-re... 67 4e-10
AY033608-1|AAK52330.1| 335|Homo sapiens extracellular signal-re... 67 4e-10
AL592406-3|CAH72463.1| 795|Homo sapiens MAP/microtubule affinit... 67 4e-10
AL353612-1|CAI23529.1| 719|Homo sapiens p21(CDKN1A)-activated k... 67 4e-10
AL135935-1|CAH71126.1| 719|Homo sapiens p21(CDKN1A)-activated k... 67 4e-10
AL031652-1|CAI42211.1| 719|Homo sapiens p21(CDKN1A)-activated k... 67 4e-10
AF154845-1|AAF72103.1| 795|Homo sapiens MARK protein. 67 4e-10
AB209611-1|BAD92848.1| 453|Homo sapiens Mitogen activated prote... 67 4e-10
AB040812-1|BAA94194.1| 719|Homo sapiens protein kinase PAK5 pro... 67 4e-10
AB033090-1|BAA86578.1| 753|Homo sapiens KIAA1264 protein protein. 67 4e-10
U85755-1|AAD00575.1| 299|Homo sapiens serum-inducible kinase pr... 67 5e-10
BC034511-1|AAH34511.1| 501|Homo sapiens PAK4 protein protein. 67 5e-10
BC025282-1|AAH25282.1| 591|Homo sapiens p21(CDKN1A)-activated k... 67 5e-10
BC013879-1|AAH13879.1| 685|Homo sapiens polo-like kinase 2 (Dro... 67 5e-10
BC011368-1|AAH11368.1| 591|Homo sapiens p21(CDKN1A)-activated k... 67 5e-10
BC002921-1|AAH02921.1| 426|Homo sapiens p21(CDKN1A)-activated k... 67 5e-10
AY629298-1|AAT65492.1| 476|Homo sapiens small intestine SPAK-li... 67 5e-10
AK222581-1|BAD96301.1| 556|Homo sapiens 3-phosphoinositide depe... 67 5e-10
AK098163-1|BAC05247.1| 372|Homo sapiens protein ( Homo sapiens ... 67 5e-10
AK074728-1|BAC11166.1| 240|Homo sapiens protein ( Homo sapiens ... 67 5e-10
AJ785968-1|CAH05056.1| 396|Homo sapiens PDPK2 protein protein. 67 5e-10
AJ011855-1|CAA09820.1| 591|Homo sapiens PAK4 protein protein. 67 5e-10
AF223574-1|AAF62897.1| 685|Homo sapiens serum-inducible kinase ... 67 5e-10
AF059617-1|AAC14573.1| 685|Homo sapiens serum-inducible kinase ... 67 5e-10
AF005046-1|AAD01210.1| 591|Homo sapiens serine/threonine kinase... 67 5e-10
AB062450-1|BAB85632.1| 302|Homo sapiens NEK7 protein. 67 5e-10
AB032968-1|BAA86456.1| 467|Homo sapiens KIAA1142 protein protein. 67 5e-10
Z11696-1|CAA77754.1| 355|Homo sapiens 44kDa protein kinase prot... 66 7e-10
X97630-1|CAA66229.1| 745|Homo sapiens serine/threonine protein ... 66 7e-10
M84490-1|AAA36142.1| 366|Homo sapiens kinase 1 protein. 66 7e-10
BX537897-1|CAD97888.1| 323|Homo sapiens hypothetical protein pr... 66 7e-10
BT007342-1|AAP36006.1| 755|Homo sapiens MAP/microtubule affinit... 66 7e-10
BC084540-1|AAH84540.1| 724|Homo sapiens MAP/microtubule affinit... 66 7e-10
BC013992-1|AAH13992.1| 379|Homo sapiens mitogen-activated prote... 66 7e-10
BC008771-1|AAH08771.2| 778|Homo sapiens MARK2 protein protein. 66 7e-10
AF387638-1|AAK82368.1| 691|Homo sapiens Ser/Thr protein kinase ... 66 7e-10
AC017006-1|AAX93253.1| 258|Homo sapiens unknown protein. 66 7e-10
AB188493-1|BAD37141.1| 719|Homo sapiens serine/threonine kinase... 66 7e-10
Z92542-3|CAI42485.1| 1030|Homo sapiens cyclin-dependent kinase-l... 66 9e-10
Y15057-1|CAA75342.1| 1030|Homo sapiens STK9 protein protein. 66 9e-10
X80692-1|CAA56709.1| 721|Homo sapiens p97mapk protein. 66 9e-10
M80629-1|AAA58424.1| 418|Homo sapiens cdc2-related protein kina... 66 9e-10
L77964-1|AAA98769.1| 721|Homo sapiens ERK3 protein kinase protein. 66 9e-10
BC035492-1|AAH35492.1| 721|Homo sapiens mitogen-activated prote... 66 9e-10
BC015515-1|AAH15515.1| 451|Homo sapiens Unknown (protein for IM... 66 9e-10
BC007992-1|AAH07992.1| 677|Homo sapiens mitogen-activated prote... 66 9e-10
BC007404-1|AAH07404.1| 677|Homo sapiens mitogen-activated prote... 66 9e-10
BC001274-1|AAH01274.1| 324|Homo sapiens CDC2L5 protein protein. 66 9e-10
AY574905-1|AAT81414.1| 462|Homo sapiens regulated in COPD kinas... 66 9e-10
AY574904-1|AAT81413.1| 510|Homo sapiens regulated in COPD kinas... 66 9e-10
AY574902-1|AAT81411.1| 1215|Homo sapiens regulated in COPD kinas... 66 9e-10
AY574901-1|AAT81410.1| 1328|Homo sapiens regulated in COPD kinas... 66 9e-10
AY217744-1|AAO64440.1| 1030|Homo sapiens serine/threonine kinase... 66 9e-10
AY212247-1|AAO32626.1| 1239|Homo sapiens Ste20 group protein kin... 66 9e-10
AL109798-1|CAI41159.1| 1030|Homo sapiens cyclin-dependent kinase... 66 9e-10
AF420474-1|AAL17605.1| 721|Homo sapiens ERK-3 protein. 66 9e-10
AF096300-1|AAD16137.1| 1165|Homo sapiens HPK/GCK-like kinase HGK... 66 9e-10
AC005035-1|AAY14969.1| 1260|Homo sapiens unknown protein. 66 9e-10
AB014587-1|BAA31662.1| 1175|Homo sapiens KIAA0687 protein protein. 66 9e-10
Y13120-1|CAA73587.1| 346|Homo sapiens serine/threonine protein ... 66 1e-09
X79193-1|CAA55785.1| 346|Homo sapiens MO15/CDK-activating kinas... 66 1e-09
X77743-1|CAA54793.1| 346|Homo sapiens CDK activating kinase pro... 66 1e-09
X77303-1|CAA54508.1| 346|Homo sapiens Cdk-activating kinase pro... 66 1e-09
U35005-1|AAC50611.1| 427|Homo sapiens JNK1 beta2 protein kinase... 66 1e-09
U35004-1|AAC50610.1| 384|Homo sapiens JNK1 beta1 protein kinase... 66 1e-09
L20321-1|AAA36658.1| 841|Homo sapiens protein serine/threonine ... 66 1e-09
L20320-1|AAA36657.1| 346|Homo sapiens protein serine/threonine ... 66 1e-09
BC130572-1|AAI30573.1| 427|Homo sapiens mitogen-activated prote... 66 1e-09
BC130570-1|AAI30571.1| 427|Homo sapiens mitogen-activated prote... 66 1e-09
BC063044-1|AAH63044.1| 781|Homo sapiens NEK4 protein protein. 66 1e-09
BC043487-1|AAH43487.1| 505|Homo sapiens calcium/calmodulin-depe... 66 1e-09
BC000834-1|AAH00834.1| 346|Homo sapiens cyclin-dependent kinase... 66 1e-09
AY130859-1|AAM77799.1| 346|Homo sapiens cyclin-dependent kinase... 66 1e-09
AK074578-1|BAC11070.1| 426|Homo sapiens protein ( Homo sapiens ... 66 1e-09
AF425301-1|AAN37387.1| 505|Homo sapiens CAMKK alpha protein pro... 66 1e-09
AF425232-1|AAN37386.1| 505|Homo sapiens CaMKK alpha protein pro... 66 1e-09
AC005581-1|AAC33487.1| 462|Homo sapiens R31237_1, partial CDS p... 66 1e-09
U35003-1|AAC50609.1| 424|Homo sapiens JNK2 beta2 protein kinase... 65 2e-09
U35002-1|AAC50608.1| 382|Homo sapiens JNK2 beta1 protein kinase... 65 2e-09
L15388-1|AAA58620.1| 590|Homo sapiens G protein-coupled recepto... 65 2e-09
D79997-1|BAA11492.2| 656|Homo sapiens KIAA0175 protein. 65 2e-09
CR542222-1|CAG47018.1| 306|Homo sapiens NEK6 protein. 65 2e-09
CR536581-1|CAG38818.1| 429|Homo sapiens SGKL protein. 65 2e-09
CR457091-1|CAG33372.1| 306|Homo sapiens NEK6 protein. 65 2e-09
BC064506-1|AAH64506.1| 590|Homo sapiens G protein-coupled recep... 65 2e-09
BC015816-1|AAH15816.2| 792|Homo sapiens MAST2 protein protein. 65 2e-09
BC015326-1|AAH15326.1| 496|Homo sapiens serum/glucocorticoid re... 65 2e-09
BC014039-1|AAH14039.1| 651|Homo sapiens maternal embryonic leuc... 65 2e-09
BC012761-1|AAH12761.1| 313|Homo sapiens NIMA (never in mitosis ... 65 2e-09
BC006166-1|AAH06166.1| 792|Homo sapiens MAST2 protein protein. 65 2e-09
BC004209-1|AAH04209.2| 313|Homo sapiens NEK6 protein protein. 65 2e-09
BC004174-1|AAH04174.2| 313|Homo sapiens NEK6 protein protein. 65 2e-09
BC000101-1|AAH00101.2| 313|Homo sapiens NEK6 protein protein. 65 2e-09
AL583824-2|CAI16759.1| 590|Homo sapiens G protein-coupled recep... 65 2e-09
AL442063-1|CAI16995.2| 651|Homo sapiens maternal embryonic leuc... 65 2e-09
AL355861-4|CAI15804.1| 590|Homo sapiens G protein-coupled recep... 65 2e-09
AL355273-2|CAI16487.1| 590|Homo sapiens G protein-coupled recep... 65 2e-09
AL354932-1|CAI11034.2| 651|Homo sapiens maternal embryonic leuc... 65 2e-09
AL162724-9|CAH70254.1| 313|Homo sapiens NIMA (never in mitosis ... 65 2e-09
AL162724-8|CAH70253.1| 201|Homo sapiens NIMA (never in mitosis ... 65 2e-09
AL162724-2|CAH70247.1| 347|Homo sapiens NIMA (never in mitosis ... 65 2e-09
AL137846-13|CAI10883.1| 313|Homo sapiens NIMA (never in mitosis... 65 2e-09
AL137846-12|CAI10882.1| 201|Homo sapiens NIMA (never in mitosis... 65 2e-09
AL137846-6|CAI10876.1| 347|Homo sapiens NIMA (never in mitosis ... 65 2e-09
AK223523-1|BAD97243.1| 496|Homo sapiens serum/glucocorticoid re... 65 2e-09
AK222811-1|BAD96531.1| 651|Homo sapiens maternal embryonic leuc... 65 2e-09
AF169035-1|AAF12758.1| 429|Homo sapiens protein kinase protein. 65 2e-09
AF087909-1|AAG13417.1| 338|Homo sapiens NIMA-related kinase 6 p... 65 2e-09
AD000092-1|AAB51171.1| 1237|Homo sapiens hypothetical human seri... 65 2e-09
AB047005-1|BAB40778.1| 1734|Homo sapiens MAST205 protein. 65 2e-09
AB026289-1|BAA85045.1| 306|Homo sapiens protein kinase SID6-151... 65 2e-09
AB023190-1|BAA76817.1| 1583|Homo sapiens KIAA0973 protein protein. 65 2e-09
AB018350-1|BAA34527.2| 1329|Homo sapiens KIAA0807 protein protein. 65 2e-09
X60188-1|CAA42744.1| 379|Homo sapiens protein serine/threonine ... 65 2e-09
U34822-1|AAC50607.1| 427|Homo sapiens JNK1 alpha2 protein kinas... 65 2e-09
L26318-1|AAA36131.1| 384|Homo sapiens protein kinase protein. 65 2e-09
D84212-1|BAA23592.1| 402|Homo sapiens aurora/IPL1-related kinas... 65 2e-09
BX538345-1|CAD98108.1| 1582|Homo sapiens hypothetical protein pr... 65 2e-09
AY987010-1|AAX88805.1| 393|Homo sapiens serum/glucocorticoid re... 65 2e-09
AY679523-1|AAT74623.1| 1512|Homo sapiens cell division cycle 2-l... 65 2e-09
AY033607-1|AAK52329.1| 357|Homo sapiens extracellular signal-re... 65 2e-09
AJ297710-1|CAC10401.1| 1452|Homo sapiens CDC2L5 protein kinase p... 65 2e-09
AJ297709-1|CAC10400.1| 1512|Homo sapiens CDC2L5 protein kinase p... 65 2e-09
AF227198-1|AAF36401.1| 1490|Homo sapiens CrkRS protein. 65 2e-09
AF059198-1|AAC25991.1| 977|Homo sapiens protein kinase/endoribo... 65 2e-09
AB020711-1|BAA74927.2| 1535|Homo sapiens KIAA0904 protein protein. 65 2e-09
Z98752-8|CAI42315.1| 366|Homo sapiens serum/glucocorticoid regu... 64 3e-09
Z98752-7|CAC18509.1| 367|Homo sapiens serum/glucocorticoid regu... 64 3e-09
Z98752-5|CAI42312.1| 427|Homo sapiens serum/glucocorticoid regu... 64 3e-09
Z15114-1|CAA78820.1| 536|Homo sapiens protein kinase C gamma pr... 64 3e-09
Z15108-1|CAA78813.1| 584|Homo sapiens protein kinase C zeta pro... 64 3e-09
X52479-1|CAA36718.1| 672|Homo sapiens protein ( Human PKC alpha... 64 3e-09
U34820-1|AAC50605.1| 422|Homo sapiens JNK3 alpha1 protein kinas... 64 3e-09
U34819-1|AAC50604.1| 464|Homo sapiens JNK3 alpha2 protein kinas... 64 3e-09
U07620-1|AAC50101.1| 422|Homo sapiens MAP kinase protein. 64 3e-09
L14283-1|AAA36488.1| 592|Homo sapiens protein kinase C zeta pro... 64 3e-09
D87931-1|BAA75636.1| 1388|Homo sapiens Rho kinase protein. 64 3e-09
DQ355971-1|ABC67469.1| 1711|Homo sapiens CDC42 binding protein k... 64 3e-09
BT007082-1|AAP35745.1| 592|Homo sapiens protein kinase C, zeta ... 64 3e-09
BC130407-1|AAI30408.1| 977|Homo sapiens endoplasmic reticulum t... 64 3e-09
BC130405-1|AAI30406.1| 977|Homo sapiens endoplasmic reticulum t... 64 3e-09
BC109274-1|AAI09275.1| 672|Homo sapiens protein kinase C, alpha... 64 3e-09
BC109273-1|AAI09274.1| 672|Homo sapiens protein kinase C, alpha... 64 3e-09
BC065511-1|AAH65511.1| 367|Homo sapiens SGK2 protein protein. 64 3e-09
BC065499-1|AAH65499.1| 1797|Homo sapiens microtubule associated ... 64 3e-09
BC048261-1|AAH48261.1| 492|Homo sapiens CDC42BPB protein protein. 64 3e-09
BC047876-1|AAH47876.1| 697|Homo sapiens protein kinase C, gamma... 64 3e-09
BC047871-1|AAH47871.1| 933|Homo sapiens CDC42BPB protein protein. 64 3e-09
BC035745-1|AAH35745.1| 385|Homo sapiens calcium/calmodulin-depe... 64 3e-09
BC035057-1|AAH35057.1| 464|Homo sapiens MAPK10 protein protein. 64 3e-09
BC014270-1|AAH14270.1| 592|Homo sapiens protein kinase C, zeta ... 64 3e-09
BC014037-1|AAH14037.3| 367|Homo sapiens serum/glucocorticoid re... 64 3e-09
BC008058-1|AAH08058.1| 592|Homo sapiens protein kinase C, zeta ... 64 3e-09
AY633609-1|AAV33302.1| 672|Homo sapiens aging-associated gene 6... 64 3e-09
AL731559-2|CAI14675.1| 385|Homo sapiens calcium/calmodulin-depe... 64 3e-09
AL731559-1|CAI14674.1| 357|Homo sapiens calcium/calmodulin-depe... 64 3e-09
AL645703-1|CAI21535.1| 592|Homo sapiens protein kinase C, zeta ... 64 3e-09
AL645480-2|CAH73245.1| 792|Homo sapiens microtubule associated ... 64 3e-09
AL645480-1|CAH73244.1| 1798|Homo sapiens microtubule associated ... 64 3e-09
AL603888-3|CAI16563.1| 792|Homo sapiens microtubule associated ... 64 3e-09
AL603888-2|CAI16562.1| 1798|Homo sapiens microtubule associated ... 64 3e-09
AL603882-2|CAI16217.1| 1798|Homo sapiens microtubule associated ... 64 3e-09
AL592406-2|CAH72462.1| 758|Homo sapiens MAP/microtubule affinit... 64 3e-09
AL590822-6|CAI12484.1| 592|Homo sapiens protein kinase C, zeta ... 64 3e-09
AL512783-2|CAH74036.1| 385|Homo sapiens calcium/calmodulin-depe... 64 3e-09
AL512783-1|CAH74035.1| 357|Homo sapiens calcium/calmodulin-depe... 64 3e-09
AL512284-2|CAH71694.1| 385|Homo sapiens calcium/calmodulin-depe... 64 3e-09
AL512284-1|CAH71693.1| 357|Homo sapiens calcium/calmodulin-depe... 64 3e-09
AL391845-5|CAI15438.1| 592|Homo sapiens protein kinase C, zeta ... 64 3e-09
AL391314-2|CAI14410.1| 385|Homo sapiens calcium/calmodulin-depe... 64 3e-09
AL391314-1|CAI14409.1| 357|Homo sapiens calcium/calmodulin-depe... 64 3e-09
AL358075-6|CAI21706.1| 792|Homo sapiens microtubule associated ... 64 3e-09
AL358075-5|CAI21705.1| 1798|Homo sapiens microtubule associated ... 64 3e-09
AK027493-1|BAB55152.1| 638|Homo sapiens protein ( Homo sapiens ... 64 3e-09
AF345987-1|AAK13533.1| 697|Homo sapiens protein kinase C gamma ... 64 3e-09
AF286366-1|AAG00534.1| 357|Homo sapiens CamKI-like protein kina... 64 3e-09
AF186470-1|AAG17012.1| 427|Homo sapiens protein kinase protein. 64 3e-09
AF169034-1|AAF12757.2| 367|Homo sapiens protein kinase protein. 64 3e-09
AF128625-1|AAD37506.1| 1711|Homo sapiens CDC42-binding protein k... 64 3e-09
AC018463-2|AAX93049.1| 1337|Homo sapiens unknown protein. 64 3e-09
AB209869-1|BAD93106.1| 1006|Homo sapiens endoplasmic reticulum t... 64 3e-09
AB081726-1|BAC19846.1| 385|Homo sapiens CaM-kinase I delta prot... 64 3e-09
AB040910-1|BAA96001.1| 870|Homo sapiens KIAA1477 protein protein. 64 3e-09
AB032950-1|BAA86438.2| 1760|Homo sapiens KIAA1124 protein protein. 64 3e-09
AB014519-1|BAA31594.2| 1428|Homo sapiens KIAA0619 protein protein. 64 3e-09
Y14440-1|CAA74792.1| 364|Homo sapiens stress activated protein ... 64 4e-09
Y00272-1|CAA68376.1| 297|Homo sapiens protein ( Human cell cycl... 64 4e-09
X61622-1|CAA43807.1| 298|Homo sapiens CDK2 protein. 64 4e-09
X05360-1|CAA28963.1| 297|Homo sapiens protein ( Human CDC2 gene... 64 4e-09
U92268-1|AAB66313.1| 364|Homo sapiens mitogen activated protein... 64 4e-09
U53442-1|AAB05036.1| 372|Homo sapiens p38Beta MAP kinase protein. 64 4e-09
L07597-1|AAC82497.1| 735|Homo sapiens ribosomal protein S6 kina... 64 4e-09
DQ279722-1|ABB72677.1| 364|Homo sapiens mitogen-activated prote... 64 4e-09
CR456514-1|CAG30400.1| 364|Homo sapiens MAPK11 protein. 64 4e-09
BT007004-1|AAP35650.1| 297|Homo sapiens cell division cycle 2, ... 64 4e-09
BC107750-1|AAI07751.1| 225|Homo sapiens CDC2 protein protein. 64 4e-09
BC062584-1|AAH62584.1| 518|Homo sapiens receptor-interacting se... 64 4e-09
BC036422-1|AAH36422.1| 436|Homo sapiens hypothetical protein MG... 64 4e-09
BC028034-1|AAH28034.1| 277|Homo sapiens MAPK15 protein protein. 64 4e-09
BC027933-1|AAH27933.1| 364|Homo sapiens mitogen-activated prote... 64 4e-09
BC017306-1|AAH17306.1| 628|Homo sapiens NUAK family, SNF1-like ... 64 4e-09
BC014966-1|AAH14966.1| 735|Homo sapiens ribosomal protein S6 ki... 64 4e-09
BC014563-1|AAH14563.1| 297|Homo sapiens cell division cycle 2, ... 64 4e-09
BC007769-1|AAH07769.1| 384|Homo sapiens EIF2AK2 protein protein. 64 4e-09
BC005298-1|AAH05298.1| 346|Homo sapiens cyclin-dependent kinase... 64 4e-09
AY494983-1|AAS75517.1| 231|Homo sapiens RIP3 gamma protein. 64 4e-09
AY494982-1|AAS75516.1| 252|Homo sapiens RIP3 beta protein. 64 4e-09
AY453693-1|AAS16359.1| 518|Homo sapiens receptor interacting pr... 64 4e-09
AL627313-6|CAI14649.1| 735|Homo sapiens ribosomal protein S6 ki... 64 4e-09
AL627313-4|CAI14647.1| 578|Homo sapiens ribosomal protein S6 ki... 64 4e-09
AL022328-13|CAB51539.1| 364|Homo sapiens mitogen-activated prot... 64 4e-09
AK075275-1|BAC11512.1| 427|Homo sapiens protein ( Homo sapiens ... 64 4e-09
AK074830-1|BAC11234.1| 628|Homo sapiens protein ( Homo sapiens ... 64 4e-09
AJ541797-1|CAD62569.2| 765|Homo sapiens ankyrin repeat and kina... 64 4e-09
AF525298-1|AAM91924.1| 765|Homo sapiens X-kinase protein. 64 4e-09
>AB037759-1|BAA92576.1| 1495|Homo sapiens KIAA1338 protein protein.
Length = 1495
Score = 594 bits (1468), Expect = e-169
Identities = 439/1419 (30%), Positives = 709/1419 (49%), Gaps = 136/1419 (9%)
Query: 156 EEERQKIKDEIQRRQEILKGAGRQRVRVSSLCH-DNSTEQDCTDEKVDA------PELVF 208
+ E Q+ K+EI+ ++ + A ++R+ ++SL + D+++++D + A P+ V
Sbjct: 22 QHEIQRRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVG 81
Query: 209 YADDKMSPVKKSTRLRNMEVPCTCNTRG---VQVLRVTQRNNKKVYIGSCLGHSST-GAT 264
+ + +S R R V + ++ G + + + V+ G C+G G
Sbjct: 82 NGKHRANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKL 141
Query: 265 TYLAIDDDTGESLIAKKWSIP------PASDFQTRNK------QLTSIQQDVKSLARLSN 312
Y A++ TG ++ +W + P Q + K Q+ + + SL +LS+
Sbjct: 142 VYNALETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSH 201
Query: 313 ASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVA 372
+++ Y+AM + ++ + I + G SL LS S V L R+ A
Sbjct: 202 PNVVRYLAMNL----KEQDDSIVVDILVEHISGVSL---AAHLS-HSGPIPVHQLRRYTA 253
Query: 373 DGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAEMLDND-------NY 425
+LS L+ LH+ +++H+ + + NV VD G VK+ S+ RLA++ D +
Sbjct: 254 Q-LLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRF 312
Query: 426 CDKQTPAQ-----DIYATGQLLLSIV----CKEKSYTEIPQELPCVAKDFISRCLTEDEH 476
D P + D++ G LLLS+ C E T IP +LP +DF+ +C+ D+
Sbjct: 313 SDNALPYKTGKKGDVWRLGLLLLSLSQGQECGEYPVT-IPSDLPADFQDFLKKCVCLDDK 371
Query: 477 SQWSAKQLMSHYFLVEAPTKKPYVKRAXXXXXXXXXXXAV---KKIRHMSF---ANNGLS 530
+WS +QL+ H F+ P K P V+++ V ++ +F S
Sbjct: 372 ERWSPQQLLKHSFINPQP-KMPLVEQSPEDSGGQDYVETVIPSNRLPSAAFFSETQRQFS 430
Query: 531 RLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL 590
R EFE L LGKGAFG V+KV+NKLDG YA+KR+ +NP S Q ++I EV LLSRL
Sbjct: 431 RYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQF-RRIKGEVTLLSRL 489
Query: 591 NHENVVRYYNAWIESTTEPIDCEESPTKT-PTRKPS-------------LEGIVAKLGQE 636
+HEN+VRYYNAWIE P P + P K L+ + A
Sbjct: 490 HHENIVRYYNAWIERHERPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPP 549
Query: 637 V---KVEWSMS-------EGPAQMTNSXXXXXXXXXXXXXXWFNIISPGDESSELIEFEK 686
+ VEWS S PA S + P +S I F+
Sbjct: 550 ILSSSVEWSTSGERSASARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDN 609
Query: 687 TSDDEESQTLPSEDVVDA-------PRPQSERLKQVLYIQMEFCEKHTLRQAIDNGLFQE 739
++ +SQ ED + P +E + LYIQME+CEK TLR ID GL+++
Sbjct: 610 EDENSKSQN-QDEDCNEKNGCHESEPSVTTEAV-HYLYIQMEYCEKSTLRDTIDQGLYRD 667
Query: 740 HFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATK--AFTGLPV 797
R WRLFREI++GLA++H++GMIHRDLKPVNIFLDS+DHVKIGDFGLAT AF+
Sbjct: 668 TVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSK 727
Query: 798 EDKTKQEEI----GGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPP 853
+D + I G LTG +GTALYV+PE +Q +TK YNQKVD++SLGII FEM + P
Sbjct: 728 QDDQTGDLIKSDPSGHLTGMVGTALYVSPE-VQGSTKSAYNQKVDLFSLGIIFFEMSYHP 786
Query: 854 LETGMERMMVLTNLRS-KDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEH 912
+ T ER+ VL LR P FD E+ KQ VI WLLNH+ + RPT ELL SE
Sbjct: 787 MVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSEL 846
Query: 913 V-PRAVPEXXXXXXXXXXXXDRTARGYQRLVAACLDQRPSAAEDYTYHN-----GMKTKP 966
+ P + E + + Y+ ++A QR S A DYTY + +
Sbjct: 847 LPPPQMEESELHEVLHHTLTNVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRT 906
Query: 967 ARLLEFVKDAVVKVFKSHGALEFAPPLLIPRARAWDQYPNAVKVMTSSGSVCHLPHDLRL 1026
A++ + V + ++++FK HGA++ PLL+PR R ++ A M SG + LP DLR+
Sbjct: 907 AKMQQHVCETIIRIFKRHGAVQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRI 966
Query: 1027 PFARHIAYSGIKNLRRFIVDRVYREKHVQGFHPKEILECAYDIVTPKTDSLWPDAELI-- 1084
PFAR++A + I NL+R+ ++RV+R + + FHPKE+LECA+DIVT T+S P AE+I
Sbjct: 967 PFARYVARNNILNLKRYCIERVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYT 1026
Query: 1085 --EVASRAASECSLKVSIQLNHTELIRVLLQSCGVPTDKQADIYPVLVDVSFGRIXXXXX 1142
E+ + SI LNHT L++ +L CG+P DK + +Y +L D ++
Sbjct: 1027 IYEIIQEFPALQERNYSIYLNHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREV 1086
Query: 1143 XXXXXXXCITNRDVTNLVRLMEADAPVQELRELVTPLVKQ-AKCSRIASQAVHDLEAVYR 1201
+++ + L + +E +Q+L + L+KQ +++ + DLE V
Sbjct: 1087 EAKFCNLSLSSNSLCRLYKFIEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVG 1146
Query: 1202 NAKALGCECPMTVAPLSAYNVTQHSGVFWQ-MSVVRSEQKSITKRRSGDLIAAGGRYDAL 1260
K LG + + + Y V QH+G+ +Q ++ ++ Q+++ +++AAGGRYD L
Sbjct: 1147 LLKKLGIKLQVLINLGLVYKVQQHNGIIFQFVAFIKRRQRAVP-----EILAAGGRYDLL 1201
Query: 1261 VKEFWNVASAENDQDSADLNVCSVGFSMSLERMAAFLNKLETQTNVPIKSNETPLVHVRV 1320
+ +F Q + ++G S+++++++A + L + +V I S + +V V
Sbjct: 1202 IPQF------RGPQALGPVPT-AIGVSIAIDKISAAV--LNMEESVTISSCDLLVVSVGQ 1252
Query: 1321 WXXXXXXXXXXXXXXXXXXXXDL--WAGGLRAGLHAGDAPDLAPGAVLAEHDPPLVRLSC 1378
+ W+ ++ A++++ + V++
Sbjct: 1253 MSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQEYCRHHEITYVALVSDKEGSHVKVKS 1312
Query: 1379 WDQDRIREHRVPYVDVVDFIKQKI---IGDSSRNPEGSST----NRSISWSESS---EKY 1428
++++R E RV ++VD + QK+ + D E S N S+S +S E +
Sbjct: 1313 FEKERQTEKRVLETELVDHVLQKLRTKVTDERNGREASDNLAVQNLKGSFSNASGLFEIH 1372
Query: 1429 NSPNISVTFITASDRMTKNSKRHCENQINTQVTSILVSL 1467
+ + + + A ++++ +++R E Q+ T++ + L +L
Sbjct: 1373 GATVVPIVSVLAPEKLSASTRRRYETQVQTRLQTSLANL 1411
>AL157497-1|CAB75678.1| 938|Homo sapiens hypothetical protein
protein.
Length = 938
Score = 440 bits (1085), Expect = e-122
Identities = 266/783 (33%), Positives = 427/783 (54%), Gaps = 46/783 (5%)
Query: 716 LYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLD 775
LYIQME+CEK TLR ID GL+++ R WRLFREI++GLA++H++GMIHRDLKPVNIFLD
Sbjct: 87 LYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLD 146
Query: 776 SNDHVKIGDFGLATK--AFTGLPVEDKTKQEEI----GGSLTGQIGTALYVAPELLQSAT 829
S+DHVKIGDFGLAT AF+ +D + I G LTG +GTALYV+PE +Q +T
Sbjct: 147 SDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPE-VQGST 205
Query: 830 KVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVLTNLRS-KDIVIPNKFDVDENVKQIH 888
K YNQKVD++SLGII FEM + P+ T ER+ VL LR P FD E+ KQ
Sbjct: 206 KSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKS 265
Query: 889 VIRWLLNHEASLRPTCAELLASEHV-PRAVPEXXXXXXXXXXXXDRTARGYQRLVAACLD 947
VI WLLNH+ + RPT ELL SE + P + E + + Y+ ++A
Sbjct: 266 VISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLTNVDGKAYRTMMAQIFS 325
Query: 948 QRPSAAEDYTYHN-----GMKTKPARLLEFVKDAVVKVFKSHGALEFAPPLLIPRARAWD 1002
QR S A DYTY + + A++ + V + ++++FK HGA++ PLL+PR R
Sbjct: 326 QRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGAVQLCTPLLLPRNRQIY 385
Query: 1003 QYPNAVKVMTSSGSVCHLPHDLRLPFARHIAYSGIKNLRRFIVDRVYREKHVQGFHPKEI 1062
++ A M SG + LP DLR+PFAR++A + I NL+R+ ++RV+R + + FHPKE+
Sbjct: 386 EHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIERVFRPRKLDRFHPKEL 445
Query: 1063 LECAYDIVTPKTDSLWPDAELI----EVASRAASECSLKVSIQLNHTELIRVLLQSCGVP 1118
LECA+DIVT T+S P AE+I E+ + SI LNHT L++ +L CG+P
Sbjct: 446 LECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYLNHTMLLKAILLHCGIP 505
Query: 1119 TDKQADIYPVLVDVSFGRIXXXXXXXXXXXXCITNRDVTNLVRLMEADAPVQELRELVTP 1178
DK + +Y +L D ++ +++ + L + +E +Q+L +
Sbjct: 506 EDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKFIEQKGDLQDLMPTINS 565
Query: 1179 LVKQ-AKCSRIASQAVHDLEAVYRNAKALGCECPMTVAPLSAYNVTQHSGVFWQ-MSVVR 1236
L+KQ +++ + DLE V K LG + + + Y V QH+G+ +Q ++ ++
Sbjct: 566 LIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYKVQQHNGIIFQFVAFIK 625
Query: 1237 SEQKSITKRRSGDLIAAGGRYDALVKEFWNVASAENDQDSADLNVCSVGFSMSLERMAAF 1296
Q+++ +++AAGGRYD L+ +F Q + ++G S+++++++A
Sbjct: 626 RRQRAVP-----EILAAGGRYDLLIPQF------RGPQALGPVPT-AIGVSIAIDKISAA 673
Query: 1297 LNKLETQTNVPIKSNETPLVHVRVWXXXXXXXXXXXXXXXXXXXXDL--WAGGLRAGLHA 1354
+ L + +V I S + +V V + W+
Sbjct: 674 V--LNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQEY 731
Query: 1355 GDAPDLAPGAVLAEHDPPLVRLSCWDQDRIREHRVPYVDVVDFIKQKI---IGDSSRNPE 1411
++ A++++ + V++ ++++R E RV ++VD + QK+ + D E
Sbjct: 732 CRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNGRE 791
Query: 1412 GSST----NRSISWSESS---EKYNSPNISVTFITASDRMTKNSKRHCENQINTQVTSIL 1464
S N S+S +S E + + + + + A ++++ +++R E Q+ T++ + L
Sbjct: 792 ASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQTSL 851
Query: 1465 VSL 1467
+L
Sbjct: 852 ANL 854
Score = 33.5 bits (73), Expect = 6.2
Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 5/79 (6%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
+YI + ++L++ + + + D + L R + DG L +H +IHRD++
Sbjct: 87 LYIQMEYCEKSTLRDTIDQ-GLYRDTVRLWRLFREILDG----LAYIHEKGMIHRDLKPV 141
Query: 396 NVFVDDVGQVKLVGASLDT 414
N+F+D VK+ L T
Sbjct: 142 NIFLDSDDHVKIGDFGLAT 160
>BC009350-1|AAH09350.2| 829|Homo sapiens EIF2AK4 protein protein.
Length = 829
Score = 401 bits (988), Expect = e-111
Identities = 249/757 (32%), Positives = 407/757 (53%), Gaps = 46/757 (6%)
Query: 742 RAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATK--AFTGLPVED 799
R WRLFREI++GLA++H++GMIHRDLKPVNIFLDS+DHVKIGDFGLAT AF+ +D
Sbjct: 4 RLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQD 63
Query: 800 KTKQEEI----GGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLE 855
+ I G LTG +GTALYV+PE+ Q +TK YNQKVD++SLGII FEM + P+
Sbjct: 64 DQTGDLIKSDPSGHLTGMVGTALYVSPEV-QGSTKSAYNQKVDLFSLGIIFFEMSYHPMV 122
Query: 856 TGMERMMVLTNLRSKDIV-IPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEHVP 914
T ER+ VL LR P FD E+ KQ VI WLLNH+ + RPT ELL SE +P
Sbjct: 123 TASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLP 182
Query: 915 RA-VPEXXXXXXXXXXXXDRTARGYQRLVAACLDQRPSAAEDYTYHNGM-----KTKPAR 968
+ E + + Y+ ++A QR S A DYTY + + + A+
Sbjct: 183 PPQMEESELHEVLHHTLTNVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAK 242
Query: 969 LLEFVKDAVVKVFKSHGALEFAPPLLIPRARAWDQYPNAVKVMTSSGSVCHLPHDLRLPF 1028
+ + V + ++++FK HGA++ PLL+PR R ++ A M SG + LP DLR+PF
Sbjct: 243 MQQHVCETIIRIFKRHGAVQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPF 302
Query: 1029 ARHIAYSGIKNLRRFIVDRVYREKHVQGFHPKEILECAYDIVTPKTDSLWPDAELI---- 1084
AR++A + I NL+R+ ++RV+R + + FHPKE+LECA+DIVT T+S P AE+I
Sbjct: 303 ARYVARNNILNLKRYCIERVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIY 362
Query: 1085 EVASRAASECSLKVSIQLNHTELIRVLLQSCGVPTDKQADIYPVLVDVSFGRIXXXXXXX 1144
E+ + SI LNHT L++ +L CG+P DK + +Y +L D ++
Sbjct: 363 EIIQEFPALQERNYSIYLNHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEA 422
Query: 1145 XXXXXCITNRDVTNLVRLMEADAPVQELRELVTPLVKQ-AKCSRIASQAVHDLEAVYRNA 1203
+++ + L + +E +Q+L + L+KQ +++ + DLE V
Sbjct: 423 KFCNLSLSSNSLCRLYKFIEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLL 482
Query: 1204 KALGCECPMTVAPLSAYNVTQHSGVFWQ-MSVVRSEQKSITKRRSGDLIAAGGRYDALVK 1262
K L + + + Y V QH+G+ +Q ++ ++ Q+++ +++AAGGRYD L+
Sbjct: 483 KKLCIKLQVLINLGLVYKVQQHNGIIFQFVAFIKRRQRAVP-----EILAAGGRYDLLIP 537
Query: 1263 EFWNVASAENDQDSADLNVCSVGFSMSLERMAAFLNKLETQTNVPIKSNETPLVHVRVWX 1322
+F Q + ++G S+++++++A + L + +V I S + +V V
Sbjct: 538 QF------RGPQALGPVPT-AIGVSIAIDKISAAV--LNMEESVTISSCDLLVVSVGQMS 588
Query: 1323 XXXXXXXXXXXXXXXXXXXDL--WAGGLRAGLHAGDAPDLAPGAVLAEHDPPLVRLSCWD 1380
+ W+ ++ A++++ + V++ ++
Sbjct: 589 MSRAINLTQKLWTAGITAEIMYDWSQSQEELQEYCRHHEITYVALVSDKEGSHVKVKSFE 648
Query: 1381 QDRIREHRVPYVDVVDFIKQKI---IGDSSRNPEGSST----NRSISWSESS---EKYNS 1430
++R E RV ++VD + QK+ + D E S N S+S +S E + +
Sbjct: 649 KERQTEKRVLETELVDHVLQKLRTKVTDERNGREASDNLAVQNLKGSFSNASGLFEIHGA 708
Query: 1431 PNISVTFITASDRMTKNSKRHCENQINTQVTSILVSL 1467
+ + + A ++++ +++R E Q+ T++ + L +L
Sbjct: 709 TVVPIVSVLAPEKLSASTRRRYETQVQTRLQTSLANL 745
>AK027011-1|BAB15625.1| 806|Homo sapiens protein ( Homo sapiens cDNA:
FLJ23358 fis, clone HEP14996. ).
Length = 806
Score = 369 bits (907), Expect = e-101
Identities = 236/737 (32%), Positives = 388/737 (52%), Gaps = 46/737 (6%)
Query: 762 MIHRDLKPVNIFLDSNDHVKIGDFGLATK--AFTGLPVEDKTKQEEI----GGSLTGQIG 815
MIHRDLKPVNIFLD +DHVKIGDFGLAT AF+ +D + I G LTG +G
Sbjct: 1 MIHRDLKPVNIFLDFDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVG 60
Query: 816 TALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVLTNLRSKDIV-I 874
TALYV+PE+ Q +TK YNQKVD++SLGII FEM + P+ T ER+ VL LR
Sbjct: 61 TALYVSPEV-QGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSPKF 119
Query: 875 PNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEHVPRA-VPEXXXXXXXXXXXXDR 933
P FD E+ KQ VI WLLNH+ + RPT ELL SE +P + E +
Sbjct: 120 PEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLTNV 179
Query: 934 TARGYQRLVAACLDQRPSAAEDYTYHNGM-----KTKPARLLEFVKDAVVKVFKSHGALE 988
+ Y+ ++A QR S A DYTY + + + A++ + V + ++++FK HGA++
Sbjct: 180 DGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGAVQ 239
Query: 989 FAPPLLIPRARAWDQYPNAVKVMTSSGSVCHLPHDLRLPFARHIAYSGIKNLRRFIVDRV 1048
PLL+PR R ++ A M SG + LP DLR+PFAR++A + I NL+R+ ++RV
Sbjct: 240 LCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIERV 299
Query: 1049 YREKHVQGFHPKEILECAYDIVTPKTDSLWPDAELI----EVASRAASECSLKVSIQLNH 1104
+R + + FHPKE+LECA+DIVT T+S P AE+I E+ + SI LNH
Sbjct: 300 FRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYLNH 359
Query: 1105 TELIRVLLQSCGVPTDKQADIYPVLVDVSFGRIXXXXXXXXXXXXCITNRDVTNLVRLME 1164
T L++ +L CG+P DK + +Y +L D ++ +++ + L + +E
Sbjct: 360 TMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKFIE 419
Query: 1165 ADAPVQELRELVTPLVKQ-AKCSRIASQAVHDLEAVYRNAKALGCECPMTVAPLSAYNVT 1223
+Q+L + L+KQ +++ + DLE V K LG + + + Y V
Sbjct: 420 QKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYKVQ 479
Query: 1224 QHSGVFWQ-MSVVRSEQKSITKRRSGDLIAAGGRYDALVKEFWNVASAENDQDSADLNVC 1282
QH+G+ +Q ++ ++ Q+++ +++AAGGRYD L+ +F Q +
Sbjct: 480 QHNGIIFQFVAFIKRRQRAVP-----EILAAGGRYDLLIPQF------RGPQALGPVPT- 527
Query: 1283 SVGFSMSLERMAAFLNKLETQTNVPIKSNETPLVHVRVWXXXXXXXXXXXXXXXXXXXXD 1342
++G S+++++++A + L + +V I S + +V V
Sbjct: 528 AIGVSIAIDKISAAV--LNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEI 585
Query: 1343 L--WAGGLRAGLHAGDAPDLAPGAVLAEHDPPLVRLSCWDQDRIREHRVPYVDVVDFIKQ 1400
+ W+ ++ A++++ + V++ ++++R E RV ++VD + Q
Sbjct: 586 MYDWSQSQEELQEYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQ 645
Query: 1401 KI---IGDSSRNPEGSST----NRSISWSESS---EKYNSPNISVTFITASDRMTKNSKR 1450
K+ + D E S N S+S +S E + + + + + A ++++ +++R
Sbjct: 646 KLRTKVTDERNGREASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRR 705
Query: 1451 HCENQINTQVTSILVSL 1467
E Q+ T++ + L +L
Sbjct: 706 RYETQVQTRLQTSLANL 722
>BC078179-1|AAH78179.1| 616|Homo sapiens EIF2AK4 protein protein.
Length = 616
Score = 222 bits (542), Expect = 9e-57
Identities = 184/603 (30%), Positives = 300/603 (49%), Gaps = 65/603 (10%)
Query: 4 ESYEERQNNELTALQAIYGDAVIDNRENIAWKVWRPLDIMLTLNPLHNSDIQGVHCSVTL 63
ESY +RQ++EL AL+AIYG D R + V P +I L L P + + V+ V L
Sbjct: 17 ESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLYPQGLTG-EEVYVKVDL 75
Query: 64 HLKCCNNYPDKPPSLAIHKMHGLSTDNATKLLAELETLSHQLCGEVMIFQLAQHAQQFLH 123
+KC YPD P + + GLS ++ L + LE L+ + CGEVMIF+LA H Q FL
Sbjct: 76 RVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGEVMIFELAYHVQSFLS 135
Query: 124 DHNK-PILSFYDEMLKQKNEMEKLKLHDLQTKEEEERQKIKDEIQRRQEILKG------- 175
+HNK P SF++EML+++ + E+ +L + + KEE+E+++I EIQRR+E +K
Sbjct: 136 EHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQRRKEEIKEEKKRKEM 195
Query: 176 AGRQRVRVSSLCH-DNSTEQDCTDEKVDA------PELVFYADDKMSPVKKSTRLRNMEV 228
A ++R+ ++SL + D+++++D + A P+ V + + +S R R V
Sbjct: 196 AKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHRANSSGRSRRERQYSV 255
Query: 229 PCTCNTRG---VQVLRVTQRNNKKVYIGSCLG-HSSTGATTYLAIDDDTGESLIAKKW-- 282
+ ++ G + + + V+ G C+G G Y A++ TG ++ +W
Sbjct: 256 CNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNALETATGGFVLLYEWVL 315
Query: 283 ----SIPPASDFQTR------NKQLTSIQQDVKSLARLSNASLIPYVAMEMCKEVNKRTS 332
+ P Q + KQ+ + + SL +LS+ +++ Y+AM + ++
Sbjct: 316 QWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNL----KEQDD 371
Query: 333 KQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDV 392
+ I + G S L LS S V L R+ A +LS L+ LH+ +++H+ +
Sbjct: 372 SIVVDILVEHISGVS---LAAHLS-HSGPIPVHQLRRYTAQ-LLSGLDYLHSNSVVHKVL 426
Query: 393 RSENVFVDDVGQVKLVGASLDTRLAEMLDND-------NYCDKQTPAQ-----DIYATGQ 440
+ NV VD G VK+ S+ RLA++ D + D P + D++ G
Sbjct: 427 SASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGDVWRLGL 486
Query: 441 LLLSI----VCKEKSYTEIPQELPCVAKDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTK 496
LLLS+ C E T IP +LP +DF+ +C+ D+ +WS +QL+ H F+ P K
Sbjct: 487 LLLSLSQGQECGEYPVT-IPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFINPQP-K 544
Query: 497 KPYVKRAXXXXXXXXXXXAV---KKIRHMSF---ANNGLSRLDAEFEVLAWLGKGAFGDV 550
P V+++ V ++ +F SR EFE L LGKGAFG V
Sbjct: 545 MPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGAFGAV 604
Query: 551 LKV 553
+KV
Sbjct: 605 IKV 607
Score = 35.5 bits (78), Expect = 1.5
Identities = 16/62 (25%), Positives = 33/62 (53%), Gaps = 1/62 (1%)
Query: 745 RLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQE 804
R +++ GL ++H ++H+ L N+ +D+ VKI D+ + +K + ED +Q
Sbjct: 404 RYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSI-SKRLADICKEDVFEQT 462
Query: 805 EI 806
+
Sbjct: 463 RV 464
>AJ243428-1|CAB58360.1| 548|Homo sapiens putative eIF2 alpha kinase
protein.
Length = 548
Score = 172 bits (419), Expect = 7e-42
Identities = 121/475 (25%), Positives = 234/475 (49%), Gaps = 32/475 (6%)
Query: 1011 MTSSGSVCHLPHDLRLPFARHIAYSGIKNLRRFIVDRVYREKHVQGFHPKEILECAYDIV 1070
M SG + LP DLR+PFAR++A + I L+R+ ++RV+R + + FHPKE+LECA+DIV
Sbjct: 4 MDHSGMLVMLPFDLRIPFARYVARNNILILKRYCIERVFRPRKLDRFHPKELLECAFDIV 63
Query: 1071 TPKTDSLWPDAELI----EVASRAASECSLKVSIQLNHTELIRVLLQSCGVPTDKQADIY 1126
T T+S P AE+I E+ + SI LNHT L++ +L CG+P DK + +Y
Sbjct: 64 TSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYLNHTMLLKAILLHCGIPEDKLSQVY 123
Query: 1127 PVLVDVSFGRIXXXXXXXXXXXXCITNRDVTNLVRLMEADAPVQELRELVTPLVKQ-AKC 1185
+L D ++ +++ + L + +E +Q+L + L+KQ
Sbjct: 124 IILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKFIEQKGDLQDLMPTINSLIKQKTGI 183
Query: 1186 SRIASQAVHDLEAVYRNAKALGCECPMTVAPLSAYNVTQHSGVFWQ-MSVVRSEQKSITK 1244
+++ + DLE V K LG + + + Y V QH+G+ +Q ++ ++ Q+++
Sbjct: 184 AQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYKVQQHNGIIFQFVAFIKRRQRAVP- 242
Query: 1245 RRSGDLIAAGGRYDALVKEFWNVASAENDQDSADLNVCSVGFSMSLERMAAFLNKLETQT 1304
+++AAGGRYD L+ +F Q + ++G S+++++++A + L +
Sbjct: 243 ----EILAAGGRYDLLIPQF------RGPQALGPVPT-AIGVSIAIDKISAAV--LNMEE 289
Query: 1305 NVPIKSNETPLVHVRVWXXXXXXXXXXXXXXXXXXXXDL--WAGGLRAGLHAGDAPDLAP 1362
+V I S + +V V + W+ ++
Sbjct: 290 SVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQEYCRHHEITY 349
Query: 1363 GAVLAEHDPPLVRLSCWDQDRIREHRVPYVDVVDFIKQKI---IGDSSRNPEGSST---- 1415
A++++ + V++ ++++R E RV ++VD + QK+ + D E S
Sbjct: 350 VALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNGREASDNLAVQ 409
Query: 1416 NRSISWSESS---EKYNSPNISVTFITASDRMTKNSKRHCENQINTQVTSILVSL 1467
N S+S +S E + + + + + A ++++ +++R E Q+ T++ + L +L
Sbjct: 410 NLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQTSLANL 464
>U50648-1|AAC50768.1| 551|Homo sapiens interferon-inducible
RNA-dependent protein kinase protein.
Length = 551
Score = 113 bits (271), Expect = 6e-24
Identities = 87/237 (36%), Positives = 124/237 (52%), Gaps = 30/237 (12%)
Query: 686 KTSDDEESQTLPSEDVVDAPRPQSERLK-QVLYIQMEFCEKHTLRQAIDN--GLFQEHFR 742
+TSDD +L S D S R K + L+IQMEFC+K TL Q I+ G +
Sbjct: 335 ETSDD----SLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVL 390
Query: 743 AWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTK 802
A LF +I +G+ ++H + +IHRDLKP NIFL VKIGDFGL T K
Sbjct: 391 ALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVT----------SLK 440
Query: 803 QEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMM 862
+ G T GT Y++PE + S Y ++VD+Y+LG+IL E+ H +T E
Sbjct: 441 ND---GKRTRSKGTLRYMSPEQISSQD---YGKEVDLYALGLILAELLH-VCDTAFETSK 493
Query: 863 VLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEHVPRAVPE 919
T+LR D +I + FD E +++ LL+ + RP +E+L + V + PE
Sbjct: 494 FFTDLR--DGIISDIFDKKEKT----LLQKLLSKKPEDRPNTSEILRTLTVWKKSPE 544
Score = 64.1 bits (149), Expect = 4e-09
Identities = 32/85 (37%), Positives = 48/85 (56%), Gaps = 6/85 (7%)
Query: 531 RLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL 590
R +F+ + +G G FG V K K+++DG Y IKRV+ N N+K REVK L++L
Sbjct: 262 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYN------NEKAEREVKALAKL 315
Query: 591 NHENVVRYYNAWIESTTEPIDCEES 615
+H N+V Y W +P ++S
Sbjct: 316 DHVNIVHYNGCWDGFDYDPETSDDS 340
Score = 41.1 bits (92), Expect = 0.031
Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 5/90 (5%)
Query: 328 NKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFS-DCFEVLGLLRHVADGVLSALNELHAAN 386
+ R+ +C++I F +L+ ++K G D L L + GV + +H+
Sbjct: 354 SSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGV----DYIHSKK 409
Query: 387 IIHRDVRSENVFVDDVGQVKLVGASLDTRL 416
+IHRD++ N+F+ D QVK+ L T L
Sbjct: 410 LIHRDLKPSNIFLVDTKQVKIGDFGLVTSL 439
>M85294-1|AAA18253.1| 551|Homo sapiens P1/eIF-2a protein kinase
protein.
Length = 551
Score = 113 bits (271), Expect = 6e-24
Identities = 87/237 (36%), Positives = 124/237 (52%), Gaps = 30/237 (12%)
Query: 686 KTSDDEESQTLPSEDVVDAPRPQSERLK-QVLYIQMEFCEKHTLRQAIDN--GLFQEHFR 742
+TSDD +L S D S R K + L+IQMEFC+K TL Q I+ G +
Sbjct: 335 ETSDD----SLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVL 390
Query: 743 AWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTK 802
A LF +I +G+ ++H + +IHRDLKP NIFL VKIGDFGL T K
Sbjct: 391 ALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVT----------SLK 440
Query: 803 QEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMM 862
+ G T GT Y++PE + S Y ++VD+Y+LG+IL E+ H +T E
Sbjct: 441 ND---GKRTRSKGTLRYMSPEQISSQD---YGKEVDLYALGLILAELLH-VCDTAFETSK 493
Query: 863 VLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEHVPRAVPE 919
T+LR D +I + FD E +++ LL+ + RP +E+L + V + PE
Sbjct: 494 FFTDLR--DGIISDIFDKKEKT----LLQKLLSKKPEDRPNTSEILRTLTVWKKSPE 544
Score = 64.1 bits (149), Expect = 4e-09
Identities = 32/85 (37%), Positives = 48/85 (56%), Gaps = 6/85 (7%)
Query: 531 RLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL 590
R +F+ + +G G FG V K K+++DG Y IKRV+ N N+K REVK L++L
Sbjct: 262 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYN------NEKAEREVKALAKL 315
Query: 591 NHENVVRYYNAWIESTTEPIDCEES 615
+H N+V Y W +P ++S
Sbjct: 316 DHVNIVHYNGCWDGFDYDPETSDDS 340
Score = 41.1 bits (92), Expect = 0.031
Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 5/90 (5%)
Query: 328 NKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFS-DCFEVLGLLRHVADGVLSALNELHAAN 386
+ R+ +C++I F +L+ ++K G D L L + GV + +H+
Sbjct: 354 SSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGV----DYIHSKK 409
Query: 387 IIHRDVRSENVFVDDVGQVKLVGASLDTRL 416
+IHRD++ N+F+ D QVK+ L T L
Sbjct: 410 LIHRDLKPSNIFLVDTKQVKIGDFGLVTSL 439
>M35663-1|AAA36409.1| 551|Homo sapiens protein ( Human p68 kinase
mRNA, complete cds. ).
Length = 551
Score = 113 bits (271), Expect = 6e-24
Identities = 87/237 (36%), Positives = 124/237 (52%), Gaps = 30/237 (12%)
Query: 686 KTSDDEESQTLPSEDVVDAPRPQSERLK-QVLYIQMEFCEKHTLRQAIDN--GLFQEHFR 742
+TSDD +L S D S R K + L+IQMEFC+K TL Q I+ G +
Sbjct: 335 ETSDD----SLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVL 390
Query: 743 AWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTK 802
A LF +I +G+ ++H + +IHRDLKP NIFL VKIGDFGL T K
Sbjct: 391 ALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVT----------SLK 440
Query: 803 QEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMM 862
+ G T GT Y++PE + S Y ++VD+Y+LG+IL E+ H +T E
Sbjct: 441 ND---GKRTRSKGTLRYMSPEQISSQD---YGKEVDLYALGLILAELLH-VCDTAFETSK 493
Query: 863 VLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEHVPRAVPE 919
T+LR D +I + FD E +++ LL+ + RP +E+L + V + PE
Sbjct: 494 FFTDLR--DGIISDIFDKKEKT----LLQKLLSKKPEDRPNTSEILRTLTVWKKSPE 544
Score = 64.1 bits (149), Expect = 4e-09
Identities = 32/85 (37%), Positives = 48/85 (56%), Gaps = 6/85 (7%)
Query: 531 RLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL 590
R +F+ + +G G FG V K K+++DG Y IKRV+ N N+K REVK L++L
Sbjct: 262 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYN------NEKAEREVKALAKL 315
Query: 591 NHENVVRYYNAWIESTTEPIDCEES 615
+H N+V Y W +P ++S
Sbjct: 316 DHVNIVHYNGCWDGFDYDPETSDDS 340
Score = 41.1 bits (92), Expect = 0.031
Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 5/90 (5%)
Query: 328 NKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFS-DCFEVLGLLRHVADGVLSALNELHAAN 386
+ R+ +C++I F +L+ ++K G D L L + GV + +H+
Sbjct: 354 SSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGV----DYIHSKK 409
Query: 387 IIHRDVRSENVFVDDVGQVKLVGASLDTRL 416
+IHRD++ N+F+ D QVK+ L T L
Sbjct: 410 LIHRDLKPSNIFLVDTKQVKIGDFGLVTSL 439
>BC126356-1|AAI26357.1| 1115|Homo sapiens eukaryotic translation
initiation factor 2-alpha kinase 3 protein.
Length = 1115
Score = 113 bits (271), Expect = 6e-24
Identities = 63/160 (39%), Positives = 93/160 (58%), Gaps = 7/160 (4%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGL-FQEHFRA--WRLFREIVEGLAHVHQRGMIHRDLKP 769
K LYIQM+ C K L+ ++ +E R+ +F +I E + +H +G++HRDLKP
Sbjct: 880 KVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKP 939
Query: 770 VNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSAT 829
NIF +D VK+GDFGL T + TGQ+GT LY++PE + +
Sbjct: 940 SNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNS 999
Query: 830 KVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVLTNLRS 869
Y+ KVDI+SLG+ILFE+ + P T MER+ LT++R+
Sbjct: 1000 ---YSHKVDIFSLGLILFELLY-PFSTQMERVRTLTDVRN 1035
Score = 79.4 bits (187), Expect = 9e-14
Identities = 39/84 (46%), Positives = 56/84 (66%), Gaps = 2/84 (2%)
Query: 526 NNG-LSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREV 584
N+G +SR +FE + LG+G FG V + KNK+D YAIKR++L P +K+ REV
Sbjct: 581 NSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRL-PNRELAREKVMREV 639
Query: 585 KLLSRLNHENVVRYYNAWIESTTE 608
K L++L H +VRY+NAW+E+ E
Sbjct: 640 KALAKLEHPGIVRYFNAWLEAPPE 663
>BC126354-1|AAI26355.1| 1116|Homo sapiens eukaryotic translation
initiation factor 2-alpha kinase 3 protein.
Length = 1116
Score = 113 bits (271), Expect = 6e-24
Identities = 63/160 (39%), Positives = 93/160 (58%), Gaps = 7/160 (4%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGL-FQEHFRA--WRLFREIVEGLAHVHQRGMIHRDLKP 769
K LYIQM+ C K L+ ++ +E R+ +F +I E + +H +G++HRDLKP
Sbjct: 881 KVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKP 940
Query: 770 VNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSAT 829
NIF +D VK+GDFGL T + TGQ+GT LY++PE + +
Sbjct: 941 SNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNS 1000
Query: 830 KVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVLTNLRS 869
Y+ KVDI+SLG+ILFE+ + P T MER+ LT++R+
Sbjct: 1001 ---YSHKVDIFSLGLILFELLY-PFSTQMERVRTLTDVRN 1036
Score = 79.4 bits (187), Expect = 9e-14
Identities = 39/84 (46%), Positives = 56/84 (66%), Gaps = 2/84 (2%)
Query: 526 NNG-LSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREV 584
N+G +SR +FE + LG+G FG V + KNK+D YAIKR++L P +K+ REV
Sbjct: 582 NSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRL-PNRELAREKVMREV 640
Query: 585 KLLSRLNHENVVRYYNAWIESTTE 608
K L++L H +VRY+NAW+E+ E
Sbjct: 641 KALAKLEHPGIVRYFNAWLEAPPE 664
>BC101475-1|AAI01476.1| 551|Homo sapiens eukaryotic translation
initiation factor 2-alpha kinase 2 protein.
Length = 551
Score = 113 bits (271), Expect = 6e-24
Identities = 87/237 (36%), Positives = 124/237 (52%), Gaps = 30/237 (12%)
Query: 686 KTSDDEESQTLPSEDVVDAPRPQSERLK-QVLYIQMEFCEKHTLRQAIDN--GLFQEHFR 742
+TSDD +L S D S R K + L+IQMEFC+K TL Q I+ G +
Sbjct: 335 ETSDD----SLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVL 390
Query: 743 AWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTK 802
A LF +I +G+ ++H + +IHRDLKP NIFL VKIGDFGL T K
Sbjct: 391 ALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVT----------SLK 440
Query: 803 QEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMM 862
+ G T GT Y++PE + S Y ++VD+Y+LG+IL E+ H +T E
Sbjct: 441 ND---GKRTRSKGTLRYMSPEQISSQD---YGKEVDLYALGLILAELLH-VCDTAFETSK 493
Query: 863 VLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEHVPRAVPE 919
T+LR D +I + FD E +++ LL+ + RP +E+L + V + PE
Sbjct: 494 FFTDLR--DGIISDIFDKKEKT----LLQKLLSKKPEDRPNTSEILRTLTVWKKSPE 544
Score = 64.1 bits (149), Expect = 4e-09
Identities = 32/85 (37%), Positives = 48/85 (56%), Gaps = 6/85 (7%)
Query: 531 RLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL 590
R +F+ + +G G FG V K K+++DG Y IKRV+ N N+K REVK L++L
Sbjct: 262 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYN------NEKAEREVKALAKL 315
Query: 591 NHENVVRYYNAWIESTTEPIDCEES 615
+H N+V Y W +P ++S
Sbjct: 316 DHVNIVHYNGCWDGFDYDPETSDDS 340
Score = 41.1 bits (92), Expect = 0.031
Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 5/90 (5%)
Query: 328 NKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFS-DCFEVLGLLRHVADGVLSALNELHAAN 386
+ R+ +C++I F +L+ ++K G D L L + GV + +H+
Sbjct: 354 SSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGV----DYIHSKK 409
Query: 387 IIHRDVRSENVFVDDVGQVKLVGASLDTRL 416
+IHRD++ N+F+ D QVK+ L T L
Sbjct: 410 LIHRDLKPSNIFLVDTKQVKIGDFGLVTSL 439
>BC093676-1|AAH93676.1| 551|Homo sapiens eukaryotic translation
initiation factor 2-alpha kinase 2 protein.
Length = 551
Score = 113 bits (271), Expect = 6e-24
Identities = 87/237 (36%), Positives = 124/237 (52%), Gaps = 30/237 (12%)
Query: 686 KTSDDEESQTLPSEDVVDAPRPQSERLK-QVLYIQMEFCEKHTLRQAIDN--GLFQEHFR 742
+TSDD +L S D S R K + L+IQMEFC+K TL Q I+ G +
Sbjct: 335 ETSDD----SLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVL 390
Query: 743 AWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTK 802
A LF +I +G+ ++H + +IHRDLKP NIFL VKIGDFGL T K
Sbjct: 391 ALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVT----------SLK 440
Query: 803 QEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMM 862
+ G T GT Y++PE + S Y ++VD+Y+LG+IL E+ H +T E
Sbjct: 441 ND---GKRTRSKGTLRYMSPEQISSQD---YGKEVDLYALGLILAELLH-VCDTAFETSK 493
Query: 863 VLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEHVPRAVPE 919
T+LR D +I + FD E +++ LL+ + RP +E+L + V + PE
Sbjct: 494 FFTDLR--DGIISDIFDKKEKT----LLQKLLSKKPEDRPNTSEILRTLTVWKKSPE 544
Score = 64.1 bits (149), Expect = 4e-09
Identities = 32/85 (37%), Positives = 48/85 (56%), Gaps = 6/85 (7%)
Query: 531 RLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL 590
R +F+ + +G G FG V K K+++DG Y IKRV+ N N+K REVK L++L
Sbjct: 262 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYN------NEKAEREVKALAKL 315
Query: 591 NHENVVRYYNAWIESTTEPIDCEES 615
+H N+V Y W +P ++S
Sbjct: 316 DHVNIVHYNGCWDGFDYDPETSDDS 340
Score = 41.1 bits (92), Expect = 0.031
Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 5/90 (5%)
Query: 328 NKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFS-DCFEVLGLLRHVADGVLSALNELHAAN 386
+ R+ +C++I F +L+ ++K G D L L + GV + +H+
Sbjct: 354 SSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGV----DYIHSKK 409
Query: 387 IIHRDVRSENVFVDDVGQVKLVGASLDTRL 416
+IHRD++ N+F+ D QVK+ L T L
Sbjct: 410 LIHRDLKPSNIFLVDTKQVKIGDFGLVTSL 439
>AY302136-1|AAP57628.1| 510|Homo sapiens interferon-inducible
double-stranded RNA-dependent protein kinase protein.
Length = 510
Score = 113 bits (271), Expect = 6e-24
Identities = 87/237 (36%), Positives = 124/237 (52%), Gaps = 30/237 (12%)
Query: 686 KTSDDEESQTLPSEDVVDAPRPQSERLK-QVLYIQMEFCEKHTLRQAIDN--GLFQEHFR 742
+TSDD +L S D S R K + L+IQMEFC+K TL Q I+ G +
Sbjct: 294 ETSDD----SLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVL 349
Query: 743 AWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTK 802
A LF +I +G+ ++H + +IHRDLKP NIFL VKIGDFGL T K
Sbjct: 350 ALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVT----------SLK 399
Query: 803 QEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMM 862
+ G T GT Y++PE + S Y ++VD+Y+LG+IL E+ H +T E
Sbjct: 400 ND---GKRTRSKGTLRYMSPEQISSQD---YGKEVDLYALGLILAELLH-VCDTAFETSK 452
Query: 863 VLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEHVPRAVPE 919
T+LR D +I + FD E +++ LL+ + RP +E+L + V + PE
Sbjct: 453 FFTDLR--DGIISDIFDKKEKT----LLQKLLSKKPEDRPNTSEILRTLTVWKKSPE 503
Score = 41.1 bits (92), Expect = 0.031
Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 5/90 (5%)
Query: 328 NKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFS-DCFEVLGLLRHVADGVLSALNELHAAN 386
+ R+ +C++I F +L+ ++K G D L L + GV + +H+
Sbjct: 313 SSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGV----DYIHSKK 368
Query: 387 IIHRDVRSENVFVDDVGQVKLVGASLDTRL 416
+IHRD++ N+F+ D QVK+ L T L
Sbjct: 369 LIHRDLKPSNIFLVDTKQVKIGDFGLVTSL 398
Score = 33.1 bits (72), Expect = 8.1
Identities = 14/38 (36%), Positives = 22/38 (57%)
Query: 578 KKITREVKLLSRLNHENVVRYYNAWIESTTEPIDCEES 615
+K REVK L++L+H N+V Y W +P ++S
Sbjct: 262 RKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDS 299
>AY228338-1|AAO38055.1| 551|Homo sapiens protein kinase,
interferon-inducible double stranded RNA dependent
protein.
Length = 551
Score = 113 bits (271), Expect = 6e-24
Identities = 87/237 (36%), Positives = 124/237 (52%), Gaps = 30/237 (12%)
Query: 686 KTSDDEESQTLPSEDVVDAPRPQSERLK-QVLYIQMEFCEKHTLRQAIDN--GLFQEHFR 742
+TSDD +L S D S R K + L+IQMEFC+K TL Q I+ G +
Sbjct: 335 ETSDD----SLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVL 390
Query: 743 AWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTK 802
A LF +I +G+ ++H + +IHRDLKP NIFL VKIGDFGL T K
Sbjct: 391 ALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVT----------SLK 440
Query: 803 QEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMM 862
+ G T GT Y++PE + S Y ++VD+Y+LG+IL E+ H +T E
Sbjct: 441 ND---GKRTRSKGTLRYMSPEQISSQD---YGKEVDLYALGLILAELLH-VCDTAFETSK 493
Query: 863 VLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEHVPRAVPE 919
T+LR D +I + FD E +++ LL+ + RP +E+L + V + PE
Sbjct: 494 FFTDLR--DGIISDIFDKKEKT----LLQKLLSKKPEDRPNTSEILRTLTVWKKSPE 544
Score = 64.1 bits (149), Expect = 4e-09
Identities = 32/85 (37%), Positives = 48/85 (56%), Gaps = 6/85 (7%)
Query: 531 RLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL 590
R +F+ + +G G FG V K K+++DG Y IKRV+ N N+K REVK L++L
Sbjct: 262 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYN------NEKAEREVKALAKL 315
Query: 591 NHENVVRYYNAWIESTTEPIDCEES 615
+H N+V Y W +P ++S
Sbjct: 316 DHVNIVHYNGCWDGFDYDPETSDDS 340
Score = 41.1 bits (92), Expect = 0.031
Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 5/90 (5%)
Query: 328 NKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFS-DCFEVLGLLRHVADGVLSALNELHAAN 386
+ R+ +C++I F +L+ ++K G D L L + GV + +H+
Sbjct: 354 SSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGV----DYIHSKK 409
Query: 387 IIHRDVRSENVFVDDVGQVKLVGASLDTRL 416
+IHRD++ N+F+ D QVK+ L T L
Sbjct: 410 LIHRDLKPSNIFLVDTKQVKIGDFGLVTSL 439
>AF284615-1|AAF91480.1| 1115|Homo sapiens initiation factor 2-alpha
kinase 3 protein.
Length = 1115
Score = 113 bits (271), Expect = 6e-24
Identities = 63/160 (39%), Positives = 93/160 (58%), Gaps = 7/160 (4%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGL-FQEHFRA--WRLFREIVEGLAHVHQRGMIHRDLKP 769
K LYIQM+ C K L+ ++ +E R+ +F +I E + +H +G++HRDLKP
Sbjct: 880 KVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKP 939
Query: 770 VNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSAT 829
NIF +D VK+GDFGL T + TGQ+GT LY++PE + +
Sbjct: 940 SNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNS 999
Query: 830 KVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVLTNLRS 869
Y+ KVDI+SLG+ILFE+ + P T MER+ LT++R+
Sbjct: 1000 ---YSHKVDIFSLGLILFELLY-PFSTQMERVRTLTDVRN 1035
Score = 79.4 bits (187), Expect = 9e-14
Identities = 39/84 (46%), Positives = 56/84 (66%), Gaps = 2/84 (2%)
Query: 526 NNG-LSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREV 584
N+G +SR +FE + LG+G FG V + KNK+D YAIKR++L P +K+ REV
Sbjct: 581 NSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRL-PNRELAREKVMREV 639
Query: 585 KLLSRLNHENVVRYYNAWIESTTE 608
K L++L H +VRY+NAW+E+ E
Sbjct: 640 KALAKLEHPGIVRYFNAWLEAPPE 663
>AF193339-1|AAF61199.1| 1115|Homo sapiens eukaryotic translation
initiation factor 2 alpha kinase PEK protein.
Length = 1115
Score = 113 bits (271), Expect = 6e-24
Identities = 63/160 (39%), Positives = 93/160 (58%), Gaps = 7/160 (4%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGL-FQEHFRA--WRLFREIVEGLAHVHQRGMIHRDLKP 769
K LYIQM+ C K L+ ++ +E R+ +F +I E + +H +G++HRDLKP
Sbjct: 880 KVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKP 939
Query: 770 VNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSAT 829
NIF +D VK+GDFGL T + TGQ+GT LY++PE + +
Sbjct: 940 SNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNS 999
Query: 830 KVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVLTNLRS 869
Y+ KVDI+SLG+ILFE+ + P T MER+ LT++R+
Sbjct: 1000 ---YSHKVDIFSLGLILFELLY-PFSTQMERVRTLTDVRN 1035
Score = 79.4 bits (187), Expect = 9e-14
Identities = 39/84 (46%), Positives = 56/84 (66%), Gaps = 2/84 (2%)
Query: 526 NNG-LSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREV 584
N+G +SR +FE + LG+G FG V + KNK+D YAIKR++L P +K+ REV
Sbjct: 581 NSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRL-PNRELAREKVMREV 639
Query: 585 KLLSRLNHENVVRYYNAWIESTTE 608
K L++L H +VRY+NAW+E+ E
Sbjct: 640 KALAKLEHPGIVRYFNAWLEAPPE 663
>AF110146-1|AAD19961.1| 1115|Homo sapiens eukaryotic translation
initiation factor 2 alpha kinase PEK protein.
Length = 1115
Score = 113 bits (271), Expect = 6e-24
Identities = 63/160 (39%), Positives = 93/160 (58%), Gaps = 7/160 (4%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGL-FQEHFRA--WRLFREIVEGLAHVHQRGMIHRDLKP 769
K LYIQM+ C K L+ ++ +E R+ +F +I E + +H +G++HRDLKP
Sbjct: 880 KVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKP 939
Query: 770 VNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSAT 829
NIF +D VK+GDFGL T + TGQ+GT LY++PE + +
Sbjct: 940 SNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNS 999
Query: 830 KVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVLTNLRS 869
Y+ KVDI+SLG+ILFE+ + P T MER+ LT++R+
Sbjct: 1000 ---YSHKVDIFSLGLILFELLY-PFSTQMERVRTLTDVRN 1035
Score = 79.4 bits (187), Expect = 9e-14
Identities = 39/84 (46%), Positives = 56/84 (66%), Gaps = 2/84 (2%)
Query: 526 NNG-LSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREV 584
N+G +SR +FE + LG+G FG V + KNK+D YAIKR++L P +K+ REV
Sbjct: 581 NSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRL-PNRELAREKVMREV 639
Query: 585 KLLSRLNHENVVRYYNAWIESTTE 608
K L++L H +VRY+NAW+E+ E
Sbjct: 640 KALAKLEHPGIVRYFNAWLEAPPE 663
>AC104134-2|AAY24331.1| 970|Homo sapiens unknown protein.
Length = 970
Score = 113 bits (271), Expect = 6e-24
Identities = 63/160 (39%), Positives = 93/160 (58%), Gaps = 7/160 (4%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGL-FQEHFRA--WRLFREIVEGLAHVHQRGMIHRDLKP 769
K LYIQM+ C K L+ ++ +E R+ +F +I E + +H +G++HRDLKP
Sbjct: 735 KVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKP 794
Query: 770 VNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSAT 829
NIF +D VK+GDFGL T + TGQ+GT LY++PE + +
Sbjct: 795 SNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNS 854
Query: 830 KVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVLTNLRS 869
Y+ KVDI+SLG+ILFE+ + P T MER+ LT++R+
Sbjct: 855 ---YSHKVDIFSLGLILFELLY-PFSTQMERVRTLTDVRN 890
Score = 79.4 bits (187), Expect = 9e-14
Identities = 39/84 (46%), Positives = 56/84 (66%), Gaps = 2/84 (2%)
Query: 526 NNG-LSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREV 584
N+G +SR +FE + LG+G FG V + KNK+D YAIKR++L P +K+ REV
Sbjct: 436 NSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRL-PNRELAREKVMREV 494
Query: 585 KLLSRLNHENVVRYYNAWIESTTE 608
K L++L H +VRY+NAW+E+ E
Sbjct: 495 KALAKLEHPGIVRYFNAWLEAPPE 518
>AC007899-1|AAY24317.1| 551|Homo sapiens unknown protein.
Length = 551
Score = 113 bits (271), Expect = 6e-24
Identities = 87/237 (36%), Positives = 124/237 (52%), Gaps = 30/237 (12%)
Query: 686 KTSDDEESQTLPSEDVVDAPRPQSERLK-QVLYIQMEFCEKHTLRQAIDN--GLFQEHFR 742
+TSDD +L S D S R K + L+IQMEFC+K TL Q I+ G +
Sbjct: 335 ETSDD----SLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVL 390
Query: 743 AWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTK 802
A LF +I +G+ ++H + +IHRDLKP NIFL VKIGDFGL T K
Sbjct: 391 ALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVT----------SLK 440
Query: 803 QEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMM 862
+ G T GT Y++PE + S Y ++VD+Y+LG+IL E+ H +T E
Sbjct: 441 ND---GKRTRSKGTLRYMSPEQISSQD---YGKEVDLYALGLILAELLH-VCDTAFETSK 493
Query: 863 VLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEHVPRAVPE 919
T+LR D +I + FD E +++ LL+ + RP +E+L + V + PE
Sbjct: 494 FFTDLR--DGIISDIFDKKEKT----LLQKLLSKKPEDRPNTSEILRTLTVWKKSPE 544
Score = 64.1 bits (149), Expect = 4e-09
Identities = 32/85 (37%), Positives = 48/85 (56%), Gaps = 6/85 (7%)
Query: 531 RLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL 590
R +F+ + +G G FG V K K+++DG Y IKRV+ N N+K REVK L++L
Sbjct: 262 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYN------NEKAEREVKALAKL 315
Query: 591 NHENVVRYYNAWIESTTEPIDCEES 615
+H N+V Y W +P ++S
Sbjct: 316 DHVNIVHYNGCWDGFDYDPETSDDS 340
Score = 41.1 bits (92), Expect = 0.031
Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 5/90 (5%)
Query: 328 NKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFS-DCFEVLGLLRHVADGVLSALNELHAAN 386
+ R+ +C++I F +L+ ++K G D L L + GV + +H+
Sbjct: 354 SSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGV----DYIHSKK 409
Query: 387 IIHRDVRSENVFVDDVGQVKLVGASLDTRL 416
+IHRD++ N+F+ D QVK+ L T L
Sbjct: 410 LIHRDLKPSNIFLVDTKQVKIGDFGLVTSL 439
>AK075192-1|BAC11461.1| 630|Homo sapiens protein ( Homo sapiens
cDNA FLJ90711 fis, clone PLACE1008282, highly similar to
HEME-REGULATED EUKARYOTIC INITIATION FACTOR EIF-2-ALPHA
KINASE ).
Length = 630
Score = 111 bits (266), Expect = 3e-23
Identities = 68/170 (40%), Positives = 97/170 (57%), Gaps = 8/170 (4%)
Query: 743 AWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSND-HVKIGDFGLATKAFTGLPVEDKT 801
A ++F+E+VEG+ ++H G++HRDLKP NIFL D VKIGDFGLA +
Sbjct: 419 ATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTN 478
Query: 802 KQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERM 861
+ + + T ++GT LY +PE L+ + Y+ K D+YSLG++L E+F P T MER
Sbjct: 479 RNGKRTPTHTSRVGTCLYASPEQLEGSE---YDAKSDMYSLGVVLLELFQ-PFGTEMERA 534
Query: 862 MVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASE 911
VLT LR+ +P V Q I+ L +S RP+ +LL SE
Sbjct: 535 EVLTGLRTGQ--LPESLRKRCPV-QARYIQHLTRRNSSQRPSAIQLLQSE 581
Score = 83.4 bits (197), Expect = 6e-15
Identities = 43/90 (47%), Positives = 58/90 (64%), Gaps = 1/90 (1%)
Query: 516 VKKIRHMSFANNG-LSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESV 574
++KIR A SR EFE LA LGKG +G V KV+NKLDG +YAIK++ + +
Sbjct: 146 IQKIRSREVALEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATK 205
Query: 575 QLNKKITREVKLLSRLNHENVVRYYNAWIE 604
+ K+ REVK+L+ L H N+V Y+ AWIE
Sbjct: 206 TVCMKVLREVKVLAGLQHPNIVGYHTAWIE 235
>BC006524-1|AAH06524.1| 630|Homo sapiens eukaryotic translation
initiation factor 2-alpha kinase 1 protein.
Length = 630
Score = 110 bits (265), Expect = 3e-23
Identities = 68/170 (40%), Positives = 97/170 (57%), Gaps = 8/170 (4%)
Query: 743 AWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSND-HVKIGDFGLATKAFTGLPVEDKT 801
A ++F+E+VEG+ ++H G++HRDLKP NIFL D VKIGDFGLA +
Sbjct: 419 ATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTN 478
Query: 802 KQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERM 861
+ + + T ++GT LY +PE L+ + Y+ K D+YSLG++L E+F P T MER
Sbjct: 479 RNGKRTPTHTSRVGTCLYASPEQLEGSE---YDAKSDMYSLGVVLLELFQ-PFGTEMERA 534
Query: 862 MVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASE 911
VLT LR+ +P V Q I+ L +S RP+ +LL SE
Sbjct: 535 EVLTGLRTGQ--LPESLRKRCPV-QAKYIQHLTRRNSSQRPSAIQLLQSE 581
Score = 83.4 bits (197), Expect = 6e-15
Identities = 43/90 (47%), Positives = 58/90 (64%), Gaps = 1/90 (1%)
Query: 516 VKKIRHMSFANNG-LSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESV 574
++KIR A SR EFE LA LGKG +G V KV+NKLDG +YAIK++ + +
Sbjct: 146 IQKIRSREVALEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATK 205
Query: 575 QLNKKITREVKLLSRLNHENVVRYYNAWIE 604
+ K+ REVK+L+ L H N+V Y+ AWIE
Sbjct: 206 TVCMKVLREVKVLAGLQHPNIVGYHTAWIE 235
>AF255050-1|AAF70289.1| 629|Homo sapiens heme-regulated eukaryotic
initiation factor 2 alpha kinase protein.
Length = 629
Score = 110 bits (265), Expect = 3e-23
Identities = 68/170 (40%), Positives = 97/170 (57%), Gaps = 8/170 (4%)
Query: 743 AWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSND-HVKIGDFGLATKAFTGLPVEDKT 801
A ++F+E+VEG+ ++H G++HRDLKP NIFL D VKIGDFGLA +
Sbjct: 418 ATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTN 477
Query: 802 KQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERM 861
+ + + T ++GT LY +PE L+ + Y+ K D+YSLG++L E+F P T MER
Sbjct: 478 RNGKRTPTHTSRVGTCLYASPEQLEGSE---YDAKSDMYSLGVVLLELFQ-PFGTEMERA 533
Query: 862 MVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASE 911
VLT LR+ +P V Q I+ L +S RP+ +LL SE
Sbjct: 534 EVLTGLRTGQ--LPESLRKRCPV-QAKYIQHLTRRNSSQRPSAIQLLQSE 580
Score = 83.4 bits (197), Expect = 6e-15
Identities = 43/90 (47%), Positives = 58/90 (64%), Gaps = 1/90 (1%)
Query: 516 VKKIRHMSFANNG-LSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESV 574
++KIR A SR EFE LA LGKG +G V KV+NKLDG +YAIK++ + +
Sbjct: 145 IQKIRSREVALEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATK 204
Query: 575 QLNKKITREVKLLSRLNHENVVRYYNAWIE 604
+ K+ REVK+L+ L H N+V Y+ AWIE
Sbjct: 205 TVCMKVLREVKVLAGLQHPNIVGYHTAWIE 234
>AF183414-1|AAG09683.1| 630|Homo sapiens hemin-sensitive initiation
factor 2a kinase protein.
Length = 630
Score = 110 bits (265), Expect = 3e-23
Identities = 68/170 (40%), Positives = 97/170 (57%), Gaps = 8/170 (4%)
Query: 743 AWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSND-HVKIGDFGLATKAFTGLPVEDKT 801
A ++F+E+VEG+ ++H G++HRDLKP NIFL D VKIGDFGLA +
Sbjct: 419 ATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTN 478
Query: 802 KQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERM 861
+ + + T ++GT LY +PE L+ + Y+ K D+YSLG++L E+F P T MER
Sbjct: 479 RNGKRTPTHTSRVGTCLYASPEQLEGSE---YDAKSDMYSLGVVLLELFQ-PFGTEMERA 534
Query: 862 MVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASE 911
VLT LR+ +P V Q I+ L +S RP+ +LL SE
Sbjct: 535 EVLTGLRTGQ--LPESLRKRCPV-QAKYIQHLTRRNSSQRPSAIQLLQSE 581
Score = 83.4 bits (197), Expect = 6e-15
Identities = 43/90 (47%), Positives = 58/90 (64%), Gaps = 1/90 (1%)
Query: 516 VKKIRHMSFANNG-LSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESV 574
++KIR A SR EFE LA LGKG +G V KV+NKLDG +YAIK++ + +
Sbjct: 146 IQKIRSREVALEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATK 205
Query: 575 QLNKKITREVKLLSRLNHENVVRYYNAWIE 604
+ K+ REVK+L+ L H N+V Y+ AWIE
Sbjct: 206 TVCMKVLREVKVLAGLQHPNIVGYHTAWIE 235
>AF181071-1|AAF18391.1| 630|Homo sapiens heme-regulated initiation
factor 2-alpha kinase protein.
Length = 630
Score = 110 bits (265), Expect = 3e-23
Identities = 68/170 (40%), Positives = 97/170 (57%), Gaps = 8/170 (4%)
Query: 743 AWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSND-HVKIGDFGLATKAFTGLPVEDKT 801
A ++F+E+VEG+ ++H G++HRDLKP NIFL D VKIGDFGLA +
Sbjct: 419 ATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTN 478
Query: 802 KQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERM 861
+ + + T ++GT LY +PE L+ + Y+ K D+YSLG++L E+F P T MER
Sbjct: 479 RNGKRTPTHTSRVGTCLYASPEQLEGSE---YDAKSDMYSLGVVLLELFQ-PFGTEMERA 534
Query: 862 MVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASE 911
VLT LR+ +P V Q I+ L +S RP+ +LL SE
Sbjct: 535 EVLTGLRTGQ--LPESLRKRCPV-QAKYIQHLTRRNSSQRPSAIQLLQSE 581
Score = 81.8 bits (193), Expect = 2e-14
Identities = 42/90 (46%), Positives = 57/90 (63%), Gaps = 1/90 (1%)
Query: 516 VKKIRHMSFANNG-LSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESV 574
++KIR A SR EFE L LGKG +G V KV+NKLDG +YAIK++ + +
Sbjct: 146 IQKIRSREVALEAQTSRYLNEFEELVILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATK 205
Query: 575 QLNKKITREVKLLSRLNHENVVRYYNAWIE 604
+ K+ REVK+L+ L H N+V Y+ AWIE
Sbjct: 206 TVCMKVLREVKVLAGLQHPNIVGYHTAWIE 235
>AF147094-1|AAF66736.1| 629|Homo sapiens heme-regulated initiation
factor 2 alpha kinase protein.
Length = 629
Score = 110 bits (265), Expect = 3e-23
Identities = 68/170 (40%), Positives = 97/170 (57%), Gaps = 8/170 (4%)
Query: 743 AWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSND-HVKIGDFGLATKAFTGLPVEDKT 801
A ++F+E+VEG+ ++H G++HRDLKP NIFL D VKIGDFGLA +
Sbjct: 418 ATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTN 477
Query: 802 KQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERM 861
+ + + T ++GT LY +PE L+ + Y+ K D+YSLG++L E+F P T MER
Sbjct: 478 RNGKRTPTHTSRVGTCLYASPEQLEGSE---YDAKSDMYSLGVVLLELFQ-PFGTEMERA 533
Query: 862 MVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASE 911
VLT LR+ +P V Q I+ L +S RP+ +LL SE
Sbjct: 534 EVLTGLRTGQ--LPESLRKRCPV-QAKYIQHLTRRNSSQRPSAIQLLQSE 580
Score = 83.4 bits (197), Expect = 6e-15
Identities = 43/90 (47%), Positives = 58/90 (64%), Gaps = 1/90 (1%)
Query: 516 VKKIRHMSFANNG-LSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESV 574
++KIR A SR EFE LA LGKG +G V KV+NKLDG +YAIK++ + +
Sbjct: 146 IQKIRSREVALEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATK 205
Query: 575 QLNKKITREVKLLSRLNHENVVRYYNAWIE 604
+ K+ REVK+L+ L H N+V Y+ AWIE
Sbjct: 206 PVCMKVLREVKVLAGLQHPNIVGYHTAWIE 235
>AF100784-1|AAP97223.1| 630|Homo sapiens hemin-sensitive
inititation factor 2a kinase protein.
Length = 630
Score = 110 bits (265), Expect = 3e-23
Identities = 68/170 (40%), Positives = 97/170 (57%), Gaps = 8/170 (4%)
Query: 743 AWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSND-HVKIGDFGLATKAFTGLPVEDKT 801
A ++F+E+VEG+ ++H G++HRDLKP NIFL D VKIGDFGLA +
Sbjct: 419 ATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTN 478
Query: 802 KQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERM 861
+ + + T ++GT LY +PE L+ + Y+ K D+YSLG++L E+F P T MER
Sbjct: 479 RNGKRTPTHTSRVGTCLYASPEQLEGSE---YDAKSDMYSLGVVLLELFQ-PFGTEMERA 534
Query: 862 MVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASE 911
VLT LR+ +P V Q I+ L +S RP+ +LL SE
Sbjct: 535 EVLTGLRTGQ--LPESLRKRCPV-QAKYIQHLTRRNSSQRPSAIQLLQSE 581
Score = 83.4 bits (197), Expect = 6e-15
Identities = 43/90 (47%), Positives = 58/90 (64%), Gaps = 1/90 (1%)
Query: 516 VKKIRHMSFANNG-LSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESV 574
++KIR A SR EFE LA LGKG +G V KV+NKLDG +YAIK++ + +
Sbjct: 146 IQKIRSREVALEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATK 205
Query: 575 QLNKKITREVKLLSRLNHENVVRYYNAWIE 604
+ K+ REVK+L+ L H N+V Y+ AWIE
Sbjct: 206 TVCMKVLREVKVLAGLQHPNIVGYHTAWIE 235
>AC005995-1|AAS00388.1| 386|Homo sapiens unknown protein.
Length = 386
Score = 110 bits (265), Expect = 3e-23
Identities = 68/170 (40%), Positives = 97/170 (57%), Gaps = 8/170 (4%)
Query: 743 AWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSND-HVKIGDFGLATKAFTGLPVEDKT 801
A ++F+E+VEG+ ++H G++HRDLKP NIFL D VKIGDFGLA +
Sbjct: 175 ATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTN 234
Query: 802 KQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERM 861
+ + + T ++GT LY +PE L+ + Y+ K D+YSLG++L E+F P T MER
Sbjct: 235 RNGKRTPTHTSRVGTCLYASPEQLEGSE---YDAKSDMYSLGVVLLELFQ-PFGTEMERA 290
Query: 862 MVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASE 911
VLT LR+ +P V Q I+ L +S RP+ +LL SE
Sbjct: 291 EVLTGLRTGQ--LPESLRKRCPV-QAKYIQHLTRRNSSQRPSAIQLLQSE 337
>AB037790-1|BAA92607.1| 653|Homo sapiens KIAA1369 protein protein.
Length = 653
Score = 110 bits (265), Expect = 3e-23
Identities = 68/170 (40%), Positives = 97/170 (57%), Gaps = 8/170 (4%)
Query: 743 AWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSND-HVKIGDFGLATKAFTGLPVEDKT 801
A ++F+E+VEG+ ++H G++HRDLKP NIFL D VKIGDFGLA +
Sbjct: 442 ATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTN 501
Query: 802 KQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERM 861
+ + + T ++GT LY +PE L+ + Y+ K D+YSLG++L E+F P T MER
Sbjct: 502 RNGKRTPTHTSRVGTCLYASPEQLEGSE---YDAKSDMYSLGVVLLELFQ-PFGTEMERA 557
Query: 862 MVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASE 911
VLT LR+ +P V Q I+ L +S RP+ +LL SE
Sbjct: 558 EVLTGLRTGQ--LPESLRKRCPV-QAKYIQHLTRRNSSQRPSAIQLLQSE 604
Score = 83.4 bits (197), Expect = 6e-15
Identities = 43/90 (47%), Positives = 58/90 (64%), Gaps = 1/90 (1%)
Query: 516 VKKIRHMSFANNG-LSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESV 574
++KIR A SR EFE LA LGKG +G V KV+NKLDG +YAIK++ + +
Sbjct: 169 IQKIRSREVALEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATK 228
Query: 575 QLNKKITREVKLLSRLNHENVVRYYNAWIE 604
+ K+ REVK+L+ L H N+V Y+ AWIE
Sbjct: 229 TVCMKVLREVKVLAGLQHPNIVGYHTAWIE 258
>AF167472-1|AAF13156.1| 551|Homo sapiens double stranded RNA
activated protein kinase protein.
Length = 551
Score = 109 bits (262), Expect = 8e-23
Identities = 86/237 (36%), Positives = 122/237 (51%), Gaps = 30/237 (12%)
Query: 686 KTSDDEESQTLPSEDVVDAPRPQSERLK-QVLYIQMEFCEKHTLRQAIDN--GLFQEHFR 742
+TSDD +L S D S R K + L+IQMEFC+K TL Q I+ G +
Sbjct: 335 ETSDD----SLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVL 390
Query: 743 AWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTK 802
A LF +I +G+ ++H + +IHRDLKP NIFL VKIGDFGL T K
Sbjct: 391 ALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVT----------SLK 440
Query: 803 QEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMM 862
+ G T GT Y++PE + S Y ++VD+Y+LG+IL E+ H +T E
Sbjct: 441 ND---GKRTRSKGTLRYMSPEQISSQD---YGKEVDLYALGLILAELLH-VCDTAFETSK 493
Query: 863 VLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEHVPRAVPE 919
T+LR D +I + D E +++ LL+ RP +E+L + V + PE
Sbjct: 494 FFTDLR--DGIISDIXDKKEET----LLQKLLSKXPEDRPNTSEILRTLTVWKKSPE 544
Score = 64.1 bits (149), Expect = 4e-09
Identities = 32/85 (37%), Positives = 48/85 (56%), Gaps = 6/85 (7%)
Query: 531 RLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL 590
R +F+ + +G G FG V K K+++DG Y IKRV+ N N+K REVK L++L
Sbjct: 262 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYN------NEKAEREVKALAKL 315
Query: 591 NHENVVRYYNAWIESTTEPIDCEES 615
+H N+V Y W +P ++S
Sbjct: 316 DHVNIVHYNGCWDGFDYDPETSDDS 340
Score = 41.1 bits (92), Expect = 0.031
Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 5/90 (5%)
Query: 328 NKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFS-DCFEVLGLLRHVADGVLSALNELHAAN 386
+ R+ +C++I F +L+ ++K G D L L + GV + +H+
Sbjct: 354 SSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGV----DYIHSKK 409
Query: 387 IIHRDVRSENVFVDDVGQVKLVGASLDTRL 416
+IHRD++ N+F+ D QVK+ L T L
Sbjct: 410 LIHRDLKPSNIFLVDTKQVKIGDFGLVTSL 439
>BC057805-1|AAH57805.1| 513|Homo sapiens EIF2AK2 protein protein.
Length = 513
Score = 105 bits (252), Expect = 1e-21
Identities = 77/197 (39%), Positives = 105/197 (53%), Gaps = 26/197 (13%)
Query: 686 KTSDDEESQTLPSEDVVDAPRPQSERLK-QVLYIQMEFCEKHTLRQAIDN--GLFQEHFR 742
+TSDD +L S D S R K + L+IQMEFC+K TL Q I+ G +
Sbjct: 335 ETSDD----SLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVL 390
Query: 743 AWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTK 802
A LF +I +G+ ++H + +IHRDLKP NIFL VKIGDFGL T K
Sbjct: 391 ALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVT----------SLK 440
Query: 803 QEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMM 862
+ G T GT Y++PE + S Y ++VD+Y+LG+IL E+ H +T E
Sbjct: 441 ND---GKRTRSKGTLRYMSPEQISSQD---YGKEVDLYALGLILAELLH-VCDTAFETSK 493
Query: 863 VLTNLRSKDIVIPNKFD 879
T+LR D +I + FD
Sbjct: 494 FFTDLR--DGIISDIFD 508
Score = 64.1 bits (149), Expect = 4e-09
Identities = 32/85 (37%), Positives = 48/85 (56%), Gaps = 6/85 (7%)
Query: 531 RLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL 590
R +F+ + +G G FG V K K+++DG Y IKRV+ N N+K REVK L++L
Sbjct: 262 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYN------NEKAEREVKALAKL 315
Query: 591 NHENVVRYYNAWIESTTEPIDCEES 615
+H N+V Y W +P ++S
Sbjct: 316 DHVNIVHYNGCWDGFDYDPETSDDS 340
Score = 41.1 bits (92), Expect = 0.031
Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 5/90 (5%)
Query: 328 NKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFS-DCFEVLGLLRHVADGVLSALNELHAAN 386
+ R+ +C++I F +L+ ++K G D L L + GV + +H+
Sbjct: 354 SSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGV----DYIHSKK 409
Query: 387 IIHRDVRSENVFVDDVGQVKLVGASLDTRL 416
+IHRD++ N+F+ D QVK+ L T L
Sbjct: 410 LIHRDLKPSNIFLVDTKQVKIGDFGLVTSL 439
>BC040851-1|AAH40851.1| 513|Homo sapiens EIF2AK2 protein protein.
Length = 513
Score = 105 bits (252), Expect = 1e-21
Identities = 77/197 (39%), Positives = 105/197 (53%), Gaps = 26/197 (13%)
Query: 686 KTSDDEESQTLPSEDVVDAPRPQSERLK-QVLYIQMEFCEKHTLRQAIDN--GLFQEHFR 742
+TSDD +L S D S R K + L+IQMEFC+K TL Q I+ G +
Sbjct: 335 ETSDD----SLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVL 390
Query: 743 AWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTK 802
A LF +I +G+ ++H + +IHRDLKP NIFL VKIGDFGL T K
Sbjct: 391 ALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVT----------SLK 440
Query: 803 QEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMM 862
+ G T GT Y++PE + S Y ++VD+Y+LG+IL E+ H +T E
Sbjct: 441 ND---GKRTRSKGTLRYMSPEQISSQD---YGKEVDLYALGLILAELLH-VCDTAFETSK 493
Query: 863 VLTNLRSKDIVIPNKFD 879
T+LR D +I + FD
Sbjct: 494 FFTDLR--DGIISDIFD 508
Score = 64.1 bits (149), Expect = 4e-09
Identities = 32/85 (37%), Positives = 48/85 (56%), Gaps = 6/85 (7%)
Query: 531 RLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL 590
R +F+ + +G G FG V K K+++DG Y IKRV+ N N+K REVK L++L
Sbjct: 262 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYN------NEKAEREVKALAKL 315
Query: 591 NHENVVRYYNAWIESTTEPIDCEES 615
+H N+V Y W +P ++S
Sbjct: 316 DHVNIVHYNGCWDGFDYDPETSDDS 340
Score = 41.1 bits (92), Expect = 0.031
Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 5/90 (5%)
Query: 328 NKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFS-DCFEVLGLLRHVADGVLSALNELHAAN 386
+ R+ +C++I F +L+ ++K G D L L + GV + +H+
Sbjct: 354 SSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGV----DYIHSKK 409
Query: 387 IIHRDVRSENVFVDDVGQVKLVGASLDTRL 416
+IHRD++ N+F+ D QVK+ L T L
Sbjct: 410 LIHRDLKPSNIFLVDTKQVKIGDFGLVTSL 439
>U50062-1|AAC32232.1| 671|Homo sapiens RIP protein kinase protein.
Length = 671
Score = 89.0 bits (211), Expect = 1e-16
Identities = 59/191 (30%), Positives = 99/191 (51%), Gaps = 12/191 (6%)
Query: 720 MEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDH 779
ME+ EK L + + R+ EI+EG+ ++H +G+IH+DLKP NI +D++ H
Sbjct: 92 MEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFH 151
Query: 780 VKIGDFGLAT-KAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVD 838
+KI D GLA+ K ++ L E+ + E+ G+ GT Y+APE L +K D
Sbjct: 152 IKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLND-VNAKPTEKSD 210
Query: 839 IYSLGIILFEMF--HPPLETGMERMMVLTNLRSKDIVIPNKFDVDE----NVKQIHVIRW 892
+YS ++L+ +F P E + ++ ++S + P+ D+ E + + + W
Sbjct: 211 VYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGN--RPDVDDITEYCPREIISLMKLCW 268
Query: 893 LLNHEASLRPT 903
N EA RPT
Sbjct: 269 EANPEA--RPT 277
Score = 33.1 bits (72), Expect = 8.1
Identities = 13/52 (25%), Positives = 30/52 (57%), Gaps = 1/52 (1%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDT-RLAEMLDNDNY 425
++ + LH +IH+D++ EN+ VD+ +K+ L + ++ L+N+ +
Sbjct: 122 IIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEH 173
>BC126256-1|AAI26257.1| 671|Homo sapiens receptor
(TNFRSF)-interacting serine-threonine kinase 1 protein.
Length = 671
Score = 89.0 bits (211), Expect = 1e-16
Identities = 59/191 (30%), Positives = 99/191 (51%), Gaps = 12/191 (6%)
Query: 720 MEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDH 779
ME+ EK L + + R+ EI+EG+ ++H +G+IH+DLKP NI +D++ H
Sbjct: 92 MEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFH 151
Query: 780 VKIGDFGLAT-KAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVD 838
+KI D GLA+ K ++ L E+ + E+ G+ GT Y+APE L +K D
Sbjct: 152 IKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLND-VNAKPTEKSD 210
Query: 839 IYSLGIILFEMF--HPPLETGMERMMVLTNLRSKDIVIPNKFDVDE----NVKQIHVIRW 892
+YS ++L+ +F P E + ++ ++S + P+ D+ E + + + W
Sbjct: 211 VYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGN--RPDVDDITEYCPREIISLMKLCW 268
Query: 893 LLNHEASLRPT 903
N EA RPT
Sbjct: 269 EANPEA--RPT 277
Score = 33.1 bits (72), Expect = 8.1
Identities = 13/52 (25%), Positives = 30/52 (57%), Gaps = 1/52 (1%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDT-RLAEMLDNDNY 425
++ + LH +IH+D++ EN+ VD+ +K+ L + ++ L+N+ +
Sbjct: 122 IIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEH 173
>BC126254-1|AAI26255.1| 671|Homo sapiens receptor
(TNFRSF)-interacting serine-threonine kinase 1 protein.
Length = 671
Score = 89.0 bits (211), Expect = 1e-16
Identities = 59/191 (30%), Positives = 99/191 (51%), Gaps = 12/191 (6%)
Query: 720 MEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDH 779
ME+ EK L + + R+ EI+EG+ ++H +G+IH+DLKP NI +D++ H
Sbjct: 92 MEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFH 151
Query: 780 VKIGDFGLAT-KAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVD 838
+KI D GLA+ K ++ L E+ + E+ G+ GT Y+APE L +K D
Sbjct: 152 IKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLND-VNAKPTEKSD 210
Query: 839 IYSLGIILFEMF--HPPLETGMERMMVLTNLRSKDIVIPNKFDVDE----NVKQIHVIRW 892
+YS ++L+ +F P E + ++ ++S + P+ D+ E + + + W
Sbjct: 211 VYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGN--RPDVDDITEYCPREIISLMKLCW 268
Query: 893 LLNHEASLRPT 903
N EA RPT
Sbjct: 269 EANPEA--RPT 277
Score = 33.1 bits (72), Expect = 8.1
Identities = 13/52 (25%), Positives = 30/52 (57%), Gaps = 1/52 (1%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDT-RLAEMLDNDNY 425
++ + LH +IH+D++ EN+ VD+ +K+ L + ++ L+N+ +
Sbjct: 122 IIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEH 173
>AY682848-1|AAT74626.1| 671|Homo sapiens receptor
(TNFRSF)-interacting serine-threonine kinase 1 protein.
Length = 671
Score = 89.0 bits (211), Expect = 1e-16
Identities = 59/191 (30%), Positives = 99/191 (51%), Gaps = 12/191 (6%)
Query: 720 MEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDH 779
ME+ EK L + + R+ EI+EG+ ++H +G+IH+DLKP NI +D++ H
Sbjct: 92 MEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFH 151
Query: 780 VKIGDFGLAT-KAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVD 838
+KI D GLA+ K ++ L E+ + E+ G+ GT Y+APE L +K D
Sbjct: 152 IKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLND-VNAKPTEKSD 210
Query: 839 IYSLGIILFEMF--HPPLETGMERMMVLTNLRSKDIVIPNKFDVDE----NVKQIHVIRW 892
+YS ++L+ +F P E + ++ ++S + P+ D+ E + + + W
Sbjct: 211 VYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGN--RPDVDDITEYCPREIISLMKLCW 268
Query: 893 LLNHEASLRPT 903
N EA RPT
Sbjct: 269 EANPEA--RPT 277
Score = 33.1 bits (72), Expect = 8.1
Identities = 13/52 (25%), Positives = 30/52 (57%), Gaps = 1/52 (1%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDT-RLAEMLDNDNY 425
++ + LH +IH+D++ EN+ VD+ +K+ L + ++ L+N+ +
Sbjct: 122 IIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEH 173
>AL031963-3|CAD70625.1| 671|Homo sapiens receptor
(TNFRSF)-interacting serine-threonine kinase 1 protein.
Length = 671
Score = 89.0 bits (211), Expect = 1e-16
Identities = 59/191 (30%), Positives = 99/191 (51%), Gaps = 12/191 (6%)
Query: 720 MEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDH 779
ME+ EK L + + R+ EI+EG+ ++H +G+IH+DLKP NI +D++ H
Sbjct: 92 MEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFH 151
Query: 780 VKIGDFGLAT-KAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVD 838
+KI D GLA+ K ++ L E+ + E+ G+ GT Y+APE L +K D
Sbjct: 152 IKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLND-VNAKPTEKSD 210
Query: 839 IYSLGIILFEMF--HPPLETGMERMMVLTNLRSKDIVIPNKFDVDE----NVKQIHVIRW 892
+YS ++L+ +F P E + ++ ++S + P+ D+ E + + + W
Sbjct: 211 VYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGN--RPDVDDITEYCPREIISLMKLCW 268
Query: 893 LLNHEASLRPT 903
N EA RPT
Sbjct: 269 EANPEA--RPT 277
Score = 33.1 bits (72), Expect = 8.1
Identities = 13/52 (25%), Positives = 30/52 (57%), Gaps = 1/52 (1%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDT-RLAEMLDNDNY 425
++ + LH +IH+D++ EN+ VD+ +K+ L + ++ L+N+ +
Sbjct: 122 IIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEH 173
>D86968-1|BAA13204.2| 1626|Homo sapiens KIAA0213 protein.
Length = 1626
Score = 87.8 bits (208), Expect = 3e-16
Identities = 49/138 (35%), Positives = 81/138 (58%), Gaps = 12/138 (8%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLF-REIVEGLAHVHQRGMIHRDLKPVN 771
++ +YI ME+C++ TL + GL QEH RL+ ++I + +H+ G++HRD+K N
Sbjct: 1430 REEMYIFMEYCDEGTLEEVSRLGL-QEH--VIRLYSKQITIAINVLHEHGIVHRDIKGAN 1486
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
IFL S+ +K+GDFG + K K + + G + +GTA Y+APE++ A
Sbjct: 1487 IFLTSSGLIKLGDFGCSVKL--------KNNAQTMPGEVNSTLGTAAYMAPEVITRAKGE 1538
Query: 832 IYNQKVDIYSLGIILFEM 849
+ + DI+SLG ++ EM
Sbjct: 1539 GHGRAADIWSLGCVVIEM 1556
Score = 42.7 bits (96), Expect = 0.010
Identities = 38/155 (24%), Positives = 70/155 (45%), Gaps = 21/155 (13%)
Query: 253 GSCLGHSSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSN 312
G+ +G G Y I DTGE + K+ P +K + ++K + +
Sbjct: 1364 GNKIGEGQYGKV-YTCISVDTGELMAMKEIRFQPND-----HKTIKETADELKIFEGIKH 1417
Query: 313 ASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVA 372
+L+ Y +E+ +E +YIF + +L+ V +L G + ++R +
Sbjct: 1418 PNLVRYFGVELHREE--------MYIFMEYCDEGTLEE-VSRL-GLQE-----HVIRLYS 1462
Query: 373 DGVLSALNELHAANIIHRDVRSENVFVDDVGQVKL 407
+ A+N LH I+HRD++ N+F+ G +KL
Sbjct: 1463 KQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKL 1497
Score = 40.3 bits (90), Expect = 0.054
Identities = 16/36 (44%), Positives = 22/36 (61%)
Query: 455 IPQELPCVAKDFISRCLTEDEHSQWSAKQLMSHYFL 490
IP+ L KDF+S CL D +W+A QL+ H F+
Sbjct: 1584 IPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV 1619
Score = 37.1 bits (82), Expect = 0.50
Identities = 18/72 (25%), Positives = 37/72 (51%)
Query: 528 GLSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLL 587
GL ++ +++ +G+G +G V + G A+K ++ P + K+ E+K+
Sbjct: 1353 GLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIF 1412
Query: 588 SRLNHENVVRYY 599
+ H N+VRY+
Sbjct: 1413 EGIKHPNLVRYF 1424
>AL596452-3|CAI41309.1| 1498|Homo sapiens mitogen-activated protein
kinase kinase kinase 4 protein.
Length = 1498
Score = 87.8 bits (208), Expect = 3e-16
Identities = 49/138 (35%), Positives = 81/138 (58%), Gaps = 12/138 (8%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLF-REIVEGLAHVHQRGMIHRDLKPVN 771
++ +YI ME+C++ TL + GL QEH RL+ ++I + +H+ G++HRD+K N
Sbjct: 1362 REEMYIFMEYCDEGTLEEVSRLGL-QEH--VIRLYSKQITIAINVLHEHGIVHRDIKGAN 1418
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
IFL S+ +K+GDFG + K K + + G + +GTA Y+APE++ A
Sbjct: 1419 IFLTSSGLIKLGDFGCSVKL--------KNNAQTMPGEVNSTLGTAAYMAPEVITRAKGE 1470
Query: 832 IYNQKVDIYSLGIILFEM 849
+ + DI+SLG ++ EM
Sbjct: 1471 GHGRAADIWSLGCVVIEM 1488
Score = 42.7 bits (96), Expect = 0.010
Identities = 38/155 (24%), Positives = 70/155 (45%), Gaps = 21/155 (13%)
Query: 253 GSCLGHSSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSN 312
G+ +G G Y I DTGE + K+ P +K + ++K + +
Sbjct: 1296 GNKIGEGQYGKV-YTCISVDTGELMAMKEIRFQPND-----HKTIKETADELKIFEGIKH 1349
Query: 313 ASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVA 372
+L+ Y +E+ +E +YIF + +L+ V +L G + ++R +
Sbjct: 1350 PNLVRYFGVELHREE--------MYIFMEYCDEGTLEE-VSRL-GLQE-----HVIRLYS 1394
Query: 373 DGVLSALNELHAANIIHRDVRSENVFVDDVGQVKL 407
+ A+N LH I+HRD++ N+F+ G +KL
Sbjct: 1395 KQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKL 1429
Score = 37.1 bits (82), Expect = 0.50
Identities = 18/72 (25%), Positives = 37/72 (51%)
Query: 528 GLSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLL 587
GL ++ +++ +G+G +G V + G A+K ++ P + K+ E+K+
Sbjct: 1285 GLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIF 1344
Query: 588 SRLNHENVVRYY 599
+ H N+VRY+
Sbjct: 1345 EGIKHPNLVRYF 1356
>AL596452-2|CAI41310.1| 1544|Homo sapiens mitogen-activated protein
kinase kinase kinase 4 protein.
Length = 1544
Score = 87.8 bits (208), Expect = 3e-16
Identities = 49/138 (35%), Positives = 81/138 (58%), Gaps = 12/138 (8%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLF-REIVEGLAHVHQRGMIHRDLKPVN 771
++ +YI ME+C++ TL + GL QEH RL+ ++I + +H+ G++HRD+K N
Sbjct: 1408 REEMYIFMEYCDEGTLEEVSRLGL-QEH--VIRLYSKQITIAINVLHEHGIVHRDIKGAN 1464
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
IFL S+ +K+GDFG + K K + + G + +GTA Y+APE++ A
Sbjct: 1465 IFLTSSGLIKLGDFGCSVKL--------KNNAQTMPGEVNSTLGTAAYMAPEVITRAKGE 1516
Query: 832 IYNQKVDIYSLGIILFEM 849
+ + DI+SLG ++ EM
Sbjct: 1517 GHGRAADIWSLGCVVIEM 1534
Score = 42.7 bits (96), Expect = 0.010
Identities = 38/155 (24%), Positives = 70/155 (45%), Gaps = 21/155 (13%)
Query: 253 GSCLGHSSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSN 312
G+ +G G Y I DTGE + K+ P +K + ++K + +
Sbjct: 1342 GNKIGEGQYGKV-YTCISVDTGELMAMKEIRFQPND-----HKTIKETADELKIFEGIKH 1395
Query: 313 ASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVA 372
+L+ Y +E+ +E +YIF + +L+ V +L G + ++R +
Sbjct: 1396 PNLVRYFGVELHREE--------MYIFMEYCDEGTLEE-VSRL-GLQE-----HVIRLYS 1440
Query: 373 DGVLSALNELHAANIIHRDVRSENVFVDDVGQVKL 407
+ A+N LH I+HRD++ N+F+ G +KL
Sbjct: 1441 KQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKL 1475
Score = 37.1 bits (82), Expect = 0.50
Identities = 18/72 (25%), Positives = 37/72 (51%)
Query: 528 GLSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLL 587
GL ++ +++ +G+G +G V + G A+K ++ P + K+ E+K+
Sbjct: 1331 GLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIF 1390
Query: 588 SRLNHENVVRYY 599
+ H N+VRY+
Sbjct: 1391 EGIKHPNLVRYF 1402
>AL591045-2|CAH70639.1| 1498|Homo sapiens mitogen-activated protein
kinase kinase kinase 4 protein.
Length = 1498
Score = 87.8 bits (208), Expect = 3e-16
Identities = 49/138 (35%), Positives = 81/138 (58%), Gaps = 12/138 (8%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLF-REIVEGLAHVHQRGMIHRDLKPVN 771
++ +YI ME+C++ TL + GL QEH RL+ ++I + +H+ G++HRD+K N
Sbjct: 1362 REEMYIFMEYCDEGTLEEVSRLGL-QEH--VIRLYSKQITIAINVLHEHGIVHRDIKGAN 1418
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
IFL S+ +K+GDFG + K K + + G + +GTA Y+APE++ A
Sbjct: 1419 IFLTSSGLIKLGDFGCSVKL--------KNNAQTMPGEVNSTLGTAAYMAPEVITRAKGE 1470
Query: 832 IYNQKVDIYSLGIILFEM 849
+ + DI+SLG ++ EM
Sbjct: 1471 GHGRAADIWSLGCVVIEM 1488
Score = 42.7 bits (96), Expect = 0.010
Identities = 38/155 (24%), Positives = 70/155 (45%), Gaps = 21/155 (13%)
Query: 253 GSCLGHSSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSN 312
G+ +G G Y I DTGE + K+ P +K + ++K + +
Sbjct: 1296 GNKIGEGQYGKV-YTCISVDTGELMAMKEIRFQPND-----HKTIKETADELKIFEGIKH 1349
Query: 313 ASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVA 372
+L+ Y +E+ +E +YIF + +L+ V +L G + ++R +
Sbjct: 1350 PNLVRYFGVELHREE--------MYIFMEYCDEGTLEE-VSRL-GLQE-----HVIRLYS 1394
Query: 373 DGVLSALNELHAANIIHRDVRSENVFVDDVGQVKL 407
+ A+N LH I+HRD++ N+F+ G +KL
Sbjct: 1395 KQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKL 1429
Score = 37.1 bits (82), Expect = 0.50
Identities = 18/72 (25%), Positives = 37/72 (51%)
Query: 528 GLSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLL 587
GL ++ +++ +G+G +G V + G A+K ++ P + K+ E+K+
Sbjct: 1285 GLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIF 1344
Query: 588 SRLNHENVVRYY 599
+ H N+VRY+
Sbjct: 1345 EGIKHPNLVRYF 1356
>AL591045-1|CAH70640.1| 1544|Homo sapiens mitogen-activated protein
kinase kinase kinase 4 protein.
Length = 1544
Score = 87.8 bits (208), Expect = 3e-16
Identities = 49/138 (35%), Positives = 81/138 (58%), Gaps = 12/138 (8%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLF-REIVEGLAHVHQRGMIHRDLKPVN 771
++ +YI ME+C++ TL + GL QEH RL+ ++I + +H+ G++HRD+K N
Sbjct: 1408 REEMYIFMEYCDEGTLEEVSRLGL-QEH--VIRLYSKQITIAINVLHEHGIVHRDIKGAN 1464
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
IFL S+ +K+GDFG + K K + + G + +GTA Y+APE++ A
Sbjct: 1465 IFLTSSGLIKLGDFGCSVKL--------KNNAQTMPGEVNSTLGTAAYMAPEVITRAKGE 1516
Query: 832 IYNQKVDIYSLGIILFEM 849
+ + DI+SLG ++ EM
Sbjct: 1517 GHGRAADIWSLGCVVIEM 1534
Score = 42.7 bits (96), Expect = 0.010
Identities = 38/155 (24%), Positives = 70/155 (45%), Gaps = 21/155 (13%)
Query: 253 GSCLGHSSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSN 312
G+ +G G Y I DTGE + K+ P +K + ++K + +
Sbjct: 1342 GNKIGEGQYGKV-YTCISVDTGELMAMKEIRFQPND-----HKTIKETADELKIFEGIKH 1395
Query: 313 ASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVA 372
+L+ Y +E+ +E +YIF + +L+ V +L G + ++R +
Sbjct: 1396 PNLVRYFGVELHREE--------MYIFMEYCDEGTLEE-VSRL-GLQE-----HVIRLYS 1440
Query: 373 DGVLSALNELHAANIIHRDVRSENVFVDDVGQVKL 407
+ A+N LH I+HRD++ N+F+ G +KL
Sbjct: 1441 KQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKL 1475
Score = 37.1 bits (82), Expect = 0.50
Identities = 18/72 (25%), Positives = 37/72 (51%)
Query: 528 GLSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLL 587
GL ++ +++ +G+G +G V + G A+K ++ P + K+ E+K+
Sbjct: 1331 GLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIF 1390
Query: 588 SRLNHENVVRYY 599
+ H N+VRY+
Sbjct: 1391 EGIKHPNLVRYF 1402
>AL139393-2|CAI20815.1| 1498|Homo sapiens mitogen-activated protein
kinase kinase kinase 4 protein.
Length = 1498
Score = 87.8 bits (208), Expect = 3e-16
Identities = 49/138 (35%), Positives = 81/138 (58%), Gaps = 12/138 (8%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLF-REIVEGLAHVHQRGMIHRDLKPVN 771
++ +YI ME+C++ TL + GL QEH RL+ ++I + +H+ G++HRD+K N
Sbjct: 1362 REEMYIFMEYCDEGTLEEVSRLGL-QEH--VIRLYSKQITIAINVLHEHGIVHRDIKGAN 1418
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
IFL S+ +K+GDFG + K K + + G + +GTA Y+APE++ A
Sbjct: 1419 IFLTSSGLIKLGDFGCSVKL--------KNNAQTMPGEVNSTLGTAAYMAPEVITRAKGE 1470
Query: 832 IYNQKVDIYSLGIILFEM 849
+ + DI+SLG ++ EM
Sbjct: 1471 GHGRAADIWSLGCVVIEM 1488
Score = 42.7 bits (96), Expect = 0.010
Identities = 38/155 (24%), Positives = 70/155 (45%), Gaps = 21/155 (13%)
Query: 253 GSCLGHSSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSN 312
G+ +G G Y I DTGE + K+ P +K + ++K + +
Sbjct: 1296 GNKIGEGQYGKV-YTCISVDTGELMAMKEIRFQPND-----HKTIKETADELKIFEGIKH 1349
Query: 313 ASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVA 372
+L+ Y +E+ +E +YIF + +L+ V +L G + ++R +
Sbjct: 1350 PNLVRYFGVELHREE--------MYIFMEYCDEGTLEE-VSRL-GLQE-----HVIRLYS 1394
Query: 373 DGVLSALNELHAANIIHRDVRSENVFVDDVGQVKL 407
+ A+N LH I+HRD++ N+F+ G +KL
Sbjct: 1395 KQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKL 1429
Score = 37.1 bits (82), Expect = 0.50
Identities = 18/72 (25%), Positives = 37/72 (51%)
Query: 528 GLSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLL 587
GL ++ +++ +G+G +G V + G A+K ++ P + K+ E+K+
Sbjct: 1285 GLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIF 1344
Query: 588 SRLNHENVVRYY 599
+ H N+VRY+
Sbjct: 1345 EGIKHPNLVRYF 1356
>AL139393-1|CAI20816.1| 1544|Homo sapiens mitogen-activated protein
kinase kinase kinase 4 protein.
Length = 1544
Score = 87.8 bits (208), Expect = 3e-16
Identities = 49/138 (35%), Positives = 81/138 (58%), Gaps = 12/138 (8%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLF-REIVEGLAHVHQRGMIHRDLKPVN 771
++ +YI ME+C++ TL + GL QEH RL+ ++I + +H+ G++HRD+K N
Sbjct: 1408 REEMYIFMEYCDEGTLEEVSRLGL-QEH--VIRLYSKQITIAINVLHEHGIVHRDIKGAN 1464
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
IFL S+ +K+GDFG + K K + + G + +GTA Y+APE++ A
Sbjct: 1465 IFLTSSGLIKLGDFGCSVKL--------KNNAQTMPGEVNSTLGTAAYMAPEVITRAKGE 1516
Query: 832 IYNQKVDIYSLGIILFEM 849
+ + DI+SLG ++ EM
Sbjct: 1517 GHGRAADIWSLGCVVIEM 1534
Score = 42.7 bits (96), Expect = 0.010
Identities = 38/155 (24%), Positives = 70/155 (45%), Gaps = 21/155 (13%)
Query: 253 GSCLGHSSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSN 312
G+ +G G Y I DTGE + K+ P +K + ++K + +
Sbjct: 1342 GNKIGEGQYGKV-YTCISVDTGELMAMKEIRFQPND-----HKTIKETADELKIFEGIKH 1395
Query: 313 ASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVA 372
+L+ Y +E+ +E +YIF + +L+ V +L G + ++R +
Sbjct: 1396 PNLVRYFGVELHREE--------MYIFMEYCDEGTLEE-VSRL-GLQE-----HVIRLYS 1440
Query: 373 DGVLSALNELHAANIIHRDVRSENVFVDDVGQVKL 407
+ A+N LH I+HRD++ N+F+ G +KL
Sbjct: 1441 KQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKL 1475
Score = 37.1 bits (82), Expect = 0.50
Identities = 18/72 (25%), Positives = 37/72 (51%)
Query: 528 GLSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLL 587
GL ++ +++ +G+G +G V + G A+K ++ P + K+ E+K+
Sbjct: 1331 GLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIF 1390
Query: 588 SRLNHENVVRYY 599
+ H N+VRY+
Sbjct: 1391 EGIKHPNLVRYF 1402
>AL109942-4|CAI21477.1| 1498|Homo sapiens mitogen-activated protein
kinase kinase kinase 4 protein.
Length = 1498
Score = 87.8 bits (208), Expect = 3e-16
Identities = 49/138 (35%), Positives = 81/138 (58%), Gaps = 12/138 (8%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLF-REIVEGLAHVHQRGMIHRDLKPVN 771
++ +YI ME+C++ TL + GL QEH RL+ ++I + +H+ G++HRD+K N
Sbjct: 1362 REEMYIFMEYCDEGTLEEVSRLGL-QEH--VIRLYSKQITIAINVLHEHGIVHRDIKGAN 1418
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
IFL S+ +K+GDFG + K K + + G + +GTA Y+APE++ A
Sbjct: 1419 IFLTSSGLIKLGDFGCSVKL--------KNNAQTMPGEVNSTLGTAAYMAPEVITRAKGE 1470
Query: 832 IYNQKVDIYSLGIILFEM 849
+ + DI+SLG ++ EM
Sbjct: 1471 GHGRAADIWSLGCVVIEM 1488
Score = 42.7 bits (96), Expect = 0.010
Identities = 38/155 (24%), Positives = 70/155 (45%), Gaps = 21/155 (13%)
Query: 253 GSCLGHSSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSN 312
G+ +G G Y I DTGE + K+ P +K + ++K + +
Sbjct: 1296 GNKIGEGQYGKV-YTCISVDTGELMAMKEIRFQPND-----HKTIKETADELKIFEGIKH 1349
Query: 313 ASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVA 372
+L+ Y +E+ +E +YIF + +L+ V +L G + ++R +
Sbjct: 1350 PNLVRYFGVELHREE--------MYIFMEYCDEGTLEE-VSRL-GLQE-----HVIRLYS 1394
Query: 373 DGVLSALNELHAANIIHRDVRSENVFVDDVGQVKL 407
+ A+N LH I+HRD++ N+F+ G +KL
Sbjct: 1395 KQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKL 1429
Score = 37.1 bits (82), Expect = 0.50
Identities = 18/72 (25%), Positives = 37/72 (51%)
Query: 528 GLSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLL 587
GL ++ +++ +G+G +G V + G A+K ++ P + K+ E+K+
Sbjct: 1285 GLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIF 1344
Query: 588 SRLNHENVVRYY 599
+ H N+VRY+
Sbjct: 1345 EGIKHPNLVRYF 1356
>AL109942-3|CAC12766.2| 1544|Homo sapiens mitogen-activated protein
kinase kinase kinase 4 protein.
Length = 1544
Score = 87.8 bits (208), Expect = 3e-16
Identities = 49/138 (35%), Positives = 81/138 (58%), Gaps = 12/138 (8%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLF-REIVEGLAHVHQRGMIHRDLKPVN 771
++ +YI ME+C++ TL + GL QEH RL+ ++I + +H+ G++HRD+K N
Sbjct: 1408 REEMYIFMEYCDEGTLEEVSRLGL-QEH--VIRLYSKQITIAINVLHEHGIVHRDIKGAN 1464
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
IFL S+ +K+GDFG + K K + + G + +GTA Y+APE++ A
Sbjct: 1465 IFLTSSGLIKLGDFGCSVKL--------KNNAQTMPGEVNSTLGTAAYMAPEVITRAKGE 1516
Query: 832 IYNQKVDIYSLGIILFEM 849
+ + DI+SLG ++ EM
Sbjct: 1517 GHGRAADIWSLGCVVIEM 1534
Score = 42.7 bits (96), Expect = 0.010
Identities = 38/155 (24%), Positives = 70/155 (45%), Gaps = 21/155 (13%)
Query: 253 GSCLGHSSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSN 312
G+ +G G Y I DTGE + K+ P +K + ++K + +
Sbjct: 1342 GNKIGEGQYGKV-YTCISVDTGELMAMKEIRFQPND-----HKTIKETADELKIFEGIKH 1395
Query: 313 ASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVA 372
+L+ Y +E+ +E +YIF + +L+ V +L G + ++R +
Sbjct: 1396 PNLVRYFGVELHREE--------MYIFMEYCDEGTLEE-VSRL-GLQE-----HVIRLYS 1440
Query: 373 DGVLSALNELHAANIIHRDVRSENVFVDDVGQVKL 407
+ A+N LH I+HRD++ N+F+ G +KL
Sbjct: 1441 KQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKL 1475
Score = 37.1 bits (82), Expect = 0.50
Identities = 18/72 (25%), Positives = 37/72 (51%)
Query: 528 GLSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLL 587
GL ++ +++ +G+G +G V + G A+K ++ P + K+ E+K+
Sbjct: 1331 GLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIF 1390
Query: 588 SRLNHENVVRYY 599
+ H N+VRY+
Sbjct: 1391 EGIKHPNLVRYF 1402
>AF002715-1|AAB68804.1| 1607|Homo sapiens MAP kinase kinase kinase
protein.
Length = 1607
Score = 87.8 bits (208), Expect = 3e-16
Identities = 49/138 (35%), Positives = 81/138 (58%), Gaps = 12/138 (8%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLF-REIVEGLAHVHQRGMIHRDLKPVN 771
++ +YI ME+C++ TL + GL QEH RL+ ++I + +H+ G++HRD+K N
Sbjct: 1411 REEMYIFMEYCDEGTLEEVSRLGL-QEH--VIRLYSKQITIAINVLHEHGIVHRDIKGAN 1467
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
IFL S+ +K+GDFG + K K + + G + +GTA Y+APE++ A
Sbjct: 1468 IFLTSSGLIKLGDFGCSVKL--------KNNAQTMPGEVNSTLGTAAYMAPEVITRAKGE 1519
Query: 832 IYNQKVDIYSLGIILFEM 849
+ + DI+SLG ++ EM
Sbjct: 1520 GHGRAADIWSLGCVVIEM 1537
Score = 42.7 bits (96), Expect = 0.010
Identities = 38/155 (24%), Positives = 70/155 (45%), Gaps = 21/155 (13%)
Query: 253 GSCLGHSSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSN 312
G+ +G G Y I DTGE + K+ P +K + ++K + +
Sbjct: 1345 GNKIGEGQYGKV-YTCISVDTGELMAMKEIRFQPND-----HKTIKETADELKIFEGIKH 1398
Query: 313 ASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVA 372
+L+ Y +E+ +E +YIF + +L+ V +L G + ++R +
Sbjct: 1399 PNLVRYFGVELHREE--------MYIFMEYCDEGTLEE-VSRL-GLQE-----HVIRLYS 1443
Query: 373 DGVLSALNELHAANIIHRDVRSENVFVDDVGQVKL 407
+ A+N LH I+HRD++ N+F+ G +KL
Sbjct: 1444 KQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKL 1478
Score = 40.3 bits (90), Expect = 0.054
Identities = 16/36 (44%), Positives = 22/36 (61%)
Query: 455 IPQELPCVAKDFISRCLTEDEHSQWSAKQLMSHYFL 490
IP+ L KDF+S CL D +W+A QL+ H F+
Sbjct: 1565 IPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV 1600
Score = 37.1 bits (82), Expect = 0.50
Identities = 18/72 (25%), Positives = 37/72 (51%)
Query: 528 GLSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLL 587
GL ++ +++ +G+G +G V + G A+K ++ P + K+ E+K+
Sbjct: 1334 GLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIF 1393
Query: 588 SRLNHENVVRYY 599
+ H N+VRY+
Sbjct: 1394 EGIKHPNLVRYF 1405
>AC004895-3|AAS00356.1| 243|Homo sapiens unknown protein.
Length = 243
Score = 83.4 bits (197), Expect = 6e-15
Identities = 43/90 (47%), Positives = 58/90 (64%), Gaps = 1/90 (1%)
Query: 516 VKKIRHMSFANNG-LSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESV 574
++KIR A SR EFE LA LGKG +G V KV+NKLDG +YAIK++ + +
Sbjct: 146 IQKIRSREVALEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATK 205
Query: 575 QLNKKITREVKLLSRLNHENVVRYYNAWIE 604
+ K+ REVK+L+ L H N+V Y+ AWIE
Sbjct: 206 TVCMKVLREVKVLAGLQHPNIVGYHTAWIE 235
>BC112101-1|AAI12102.1| 979|Homo sapiens NIMA related kinase 9
protein.
Length = 979
Score = 83.0 bits (196), Expect = 8e-15
Identities = 63/199 (31%), Positives = 104/199 (52%), Gaps = 25/199 (12%)
Query: 716 LYIQMEFCEKHTLRQAI---DNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
L I++E+C L I + LF+E W LF +IV ++ +H+ G++HRD+K +NI
Sbjct: 124 LLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLF-QIVSAVSCIHKAGILHRDIKTLNI 182
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVI 832
FL + +K+GD+GLA K + + +L +GT Y++PEL Q V
Sbjct: 183 FLTKANLIKLGDYGLAKKL---------NSEYSMAETL---VGTPYYMSPELCQG---VK 227
Query: 833 YNQKVDIYSLGIILFEMFHPPLETGMERMMVLTNLRSKDIVIPNKFDVDE---NVKQIHV 889
YN K DI+++G ++FE+ L+ + L NL K + +VD +++ I +
Sbjct: 228 YNFKSDIWAVGCVIFELL--TLKRTFDATNPL-NLCVKIVQGIRAMEVDSSQYSLELIQM 284
Query: 890 IRWLLNHEASLRPTCAELL 908
+ L+ + RPT ELL
Sbjct: 285 VHSCLDQDPEQRPTADELL 303
Score = 48.8 bits (111), Expect = 2e-04
Identities = 23/72 (31%), Positives = 39/72 (54%)
Query: 542 LGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENVVRYYNA 601
LG+GAFG+ + D K V L S + + E+ +L+ L H+N++ YYN
Sbjct: 58 LGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNH 117
Query: 602 WIESTTEPIDCE 613
++++TT I+ E
Sbjct: 118 FMDNTTLLIELE 129
Score = 36.3 bits (80), Expect = 0.87
Identities = 35/139 (25%), Positives = 65/139 (46%), Gaps = 16/139 (11%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRL------AEMLDNDNY--- 425
++SA++ +H A I+HRD+++ N+F+ +KL L +L AE L Y
Sbjct: 160 IVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMS 219
Query: 426 ---CD--KQTPAQDIYATGQLLLSIVCKEKSYTEIPQELPCVAKDFISRCLTEDEHSQWS 480
C K DI+A G ++ ++ ++++ + L K E + SQ+S
Sbjct: 220 PELCQGVKYNFKSDIWAVGCVIFELLTLKRTF-DATNPLNLCVKIVQGIRAMEVDSSQYS 278
Query: 481 AKQL-MSHYFLVEAPTKKP 498
+ + M H L + P ++P
Sbjct: 279 LELIQMVHSCLDQDPEQRP 297
>BC093881-1|AAH93881.1| 979|Homo sapiens NIMA (never in mitosis
gene a)- related kinase 9 protein.
Length = 979
Score = 83.0 bits (196), Expect = 8e-15
Identities = 63/199 (31%), Positives = 104/199 (52%), Gaps = 25/199 (12%)
Query: 716 LYIQMEFCEKHTLRQAI---DNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
L I++E+C L I + LF+E W LF +IV ++ +H+ G++HRD+K +NI
Sbjct: 124 LLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLF-QIVSAVSCIHKAGILHRDIKTLNI 182
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVI 832
FL + +K+GD+GLA K + + +L +GT Y++PEL Q V
Sbjct: 183 FLTKANLIKLGDYGLAKKL---------NSEYSMAETL---VGTPYYMSPELCQG---VK 227
Query: 833 YNQKVDIYSLGIILFEMFHPPLETGMERMMVLTNLRSKDIVIPNKFDVDE---NVKQIHV 889
YN K DI+++G ++FE+ L+ + L NL K + +VD +++ I +
Sbjct: 228 YNFKSDIWAVGCVIFELL--TLKRTFDATNPL-NLCVKIVQGIRAMEVDSSQYSLELIQM 284
Query: 890 IRWLLNHEASLRPTCAELL 908
+ L+ + RPT ELL
Sbjct: 285 VHSCLDQDPEQRPTADELL 303
Score = 48.8 bits (111), Expect = 2e-04
Identities = 23/72 (31%), Positives = 39/72 (54%)
Query: 542 LGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENVVRYYNA 601
LG+GAFG+ + D K V L S + + E+ +L+ L H+N++ YYN
Sbjct: 58 LGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNH 117
Query: 602 WIESTTEPIDCE 613
++++TT I+ E
Sbjct: 118 FMDNTTLLIELE 129
Score = 36.3 bits (80), Expect = 0.87
Identities = 35/139 (25%), Positives = 65/139 (46%), Gaps = 16/139 (11%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRL------AEMLDNDNY--- 425
++SA++ +H A I+HRD+++ N+F+ +KL L +L AE L Y
Sbjct: 160 IVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMS 219
Query: 426 ---CD--KQTPAQDIYATGQLLLSIVCKEKSYTEIPQELPCVAKDFISRCLTEDEHSQWS 480
C K DI+A G ++ ++ ++++ + L K E + SQ+S
Sbjct: 220 PELCQGVKYNFKSDIWAVGCVIFELLTLKRTF-DATNPLNLCVKIVQGIRAMEVDSSQYS 278
Query: 481 AKQL-MSHYFLVEAPTKKP 498
+ + M H L + P ++P
Sbjct: 279 LELIQMVHSCLDQDPEQRP 297
>AY080896-1|AAL87410.1| 979|Homo sapiens NIMA-family kinase NERCC1
protein.
Length = 979
Score = 83.0 bits (196), Expect = 8e-15
Identities = 63/199 (31%), Positives = 104/199 (52%), Gaps = 25/199 (12%)
Query: 716 LYIQMEFCEKHTLRQAI---DNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
L I++E+C L I + LF+E W LF +IV ++ +H+ G++HRD+K +NI
Sbjct: 124 LLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLF-QIVSAVSCIHKAGILHRDIKTLNI 182
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVI 832
FL + +K+GD+GLA K + + +L +GT Y++PEL Q V
Sbjct: 183 FLTKANLIKLGDYGLAKKL---------NSEYSMAETL---VGTPYYMSPELCQG---VK 227
Query: 833 YNQKVDIYSLGIILFEMFHPPLETGMERMMVLTNLRSKDIVIPNKFDVDE---NVKQIHV 889
YN K DI+++G ++FE+ L+ + L NL K + +VD +++ I +
Sbjct: 228 YNFKSDIWAVGCVIFELL--TLKRTFDATNPL-NLCVKIVQGIRAMEVDSSQYSLELIQM 284
Query: 890 IRWLLNHEASLRPTCAELL 908
+ L+ + RPT ELL
Sbjct: 285 VHSCLDQDPEQRPTADELL 303
Score = 48.8 bits (111), Expect = 2e-04
Identities = 23/72 (31%), Positives = 39/72 (54%)
Query: 542 LGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENVVRYYNA 601
LG+GAFG+ + D K V L S + + E+ +L+ L H+N++ YYN
Sbjct: 58 LGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNH 117
Query: 602 WIESTTEPIDCE 613
++++TT I+ E
Sbjct: 118 FMDNTTLLIELE 129
Score = 36.3 bits (80), Expect = 0.87
Identities = 35/139 (25%), Positives = 65/139 (46%), Gaps = 16/139 (11%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRL------AEMLDNDNY--- 425
++SA++ +H A I+HRD+++ N+F+ +KL L +L AE L Y
Sbjct: 160 IVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMS 219
Query: 426 ---CD--KQTPAQDIYATGQLLLSIVCKEKSYTEIPQELPCVAKDFISRCLTEDEHSQWS 480
C K DI+A G ++ ++ ++++ + L K E + SQ+S
Sbjct: 220 PELCQGVKYNFKSDIWAVGCVIFELLTLKRTF-DATNPLNLCVKIVQGIRAMEVDSSQYS 278
Query: 481 AKQL-MSHYFLVEAPTKKP 498
+ + M H L + P ++P
Sbjct: 279 LELIQMVHSCLDQDPEQRP 297
>AY048580-1|AAL05428.1| 979|Homo sapiens NIMA-related kinase Nek8
protein.
Length = 979
Score = 83.0 bits (196), Expect = 8e-15
Identities = 63/199 (31%), Positives = 104/199 (52%), Gaps = 25/199 (12%)
Query: 716 LYIQMEFCEKHTLRQAI---DNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
L I++E+C L I + LF+E W LF +IV ++ +H+ G++HRD+K +NI
Sbjct: 124 LLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLF-QIVSAVSCIHKAGILHRDIKTLNI 182
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVI 832
FL + +K+GD+GLA K + + +L +GT Y++PEL Q V
Sbjct: 183 FLTKANLIKLGDYGLAKKL---------NSEYSMAETL---VGTPYYMSPELCQG---VK 227
Query: 833 YNQKVDIYSLGIILFEMFHPPLETGMERMMVLTNLRSKDIVIPNKFDVDE---NVKQIHV 889
YN K DI+++G ++FE+ L+ + L NL K + +VD +++ I +
Sbjct: 228 YNFKSDIWAVGCVIFELL--TLKRTFDATNPL-NLCVKIVQGIRAMEVDSSQYSLELIQM 284
Query: 890 IRWLLNHEASLRPTCAELL 908
+ L+ + RPT ELL
Sbjct: 285 VHSCLDQDPEQRPTADELL 303
Score = 48.8 bits (111), Expect = 2e-04
Identities = 23/72 (31%), Positives = 39/72 (54%)
Query: 542 LGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENVVRYYNA 601
LG+GAFG+ + D K V L S + + E+ +L+ L H+N++ YYN
Sbjct: 58 LGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNH 117
Query: 602 WIESTTEPIDCE 613
++++TT I+ E
Sbjct: 118 FMDNTTLLIELE 129
Score = 36.3 bits (80), Expect = 0.87
Identities = 35/139 (25%), Positives = 65/139 (46%), Gaps = 16/139 (11%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRL------AEMLDNDNY--- 425
++SA++ +H A I+HRD+++ N+F+ +KL L +L AE L Y
Sbjct: 160 IVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMS 219
Query: 426 ---CD--KQTPAQDIYATGQLLLSIVCKEKSYTEIPQELPCVAKDFISRCLTEDEHSQWS 480
C K DI+A G ++ ++ ++++ + L K E + SQ+S
Sbjct: 220 PELCQGVKYNFKSDIWAVGCVIFELLTLKRTF-DATNPLNLCVKIVQGIRAMEVDSSQYS 278
Query: 481 AKQL-MSHYFLVEAPTKKP 498
+ + M H L + P ++P
Sbjct: 279 LELIQMVHSCLDQDPEQRP 297
>AC007055-5|AAD31940.1| 312|Homo sapiens protein ( Homo sapiens
chromosome 14 clone BAC 201F1 map 14q24.3, complete
sequence. ).
Length = 312
Score = 83.0 bits (196), Expect = 8e-15
Identities = 63/199 (31%), Positives = 104/199 (52%), Gaps = 25/199 (12%)
Query: 716 LYIQMEFCEKHTLRQAI---DNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
L I++E+C L I + LF+E W LF +IV ++ +H+ G++HRD+K +NI
Sbjct: 124 LLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLF-QIVSAVSCIHKAGILHRDIKTLNI 182
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVI 832
FL + +K+GD+GLA K + + +L +GT Y++PEL Q V
Sbjct: 183 FLTKANLIKLGDYGLAKKL---------NSEYSMAETL---VGTPYYMSPELCQG---VK 227
Query: 833 YNQKVDIYSLGIILFEMFHPPLETGMERMMVLTNLRSKDIVIPNKFDVDE---NVKQIHV 889
YN K DI+++G ++FE+ L+ + L NL K + +VD +++ I +
Sbjct: 228 YNFKSDIWAVGCVIFELL--TLKRTFDATNPL-NLCVKIVQGIRAMEVDSSQYSLELIQM 284
Query: 890 IRWLLNHEASLRPTCAELL 908
+ L+ + RPT ELL
Sbjct: 285 VHSCLDQDPEQRPTADELL 303
Score = 48.8 bits (111), Expect = 2e-04
Identities = 23/72 (31%), Positives = 39/72 (54%)
Query: 542 LGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENVVRYYNA 601
LG+GAFG+ + D K V L S + + E+ +L+ L H+N++ YYN
Sbjct: 58 LGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNH 117
Query: 602 WIESTTEPIDCE 613
++++TT I+ E
Sbjct: 118 FMDNTTLLIELE 129
Score = 36.3 bits (80), Expect = 0.87
Identities = 35/139 (25%), Positives = 65/139 (46%), Gaps = 16/139 (11%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRL------AEMLDNDNY--- 425
++SA++ +H A I+HRD+++ N+F+ +KL L +L AE L Y
Sbjct: 160 IVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMS 219
Query: 426 ---CD--KQTPAQDIYATGQLLLSIVCKEKSYTEIPQELPCVAKDFISRCLTEDEHSQWS 480
C K DI+A G ++ ++ ++++ + L K E + SQ+S
Sbjct: 220 PELCQGVKYNFKSDIWAVGCVIFELLTLKRTF-DATNPLNLCVKIVQGIRAMEVDSSQYS 278
Query: 481 AKQL-MSHYFLVEAPTKKP 498
+ + M H L + P ++P
Sbjct: 279 LELIQMVHSCLDQDPEQRP 297
>AB082526-1|BAC02704.1| 1011|Homo sapiens KIAA1995 protein protein.
Length = 1011
Score = 83.0 bits (196), Expect = 8e-15
Identities = 63/199 (31%), Positives = 104/199 (52%), Gaps = 25/199 (12%)
Query: 716 LYIQMEFCEKHTLRQAI---DNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
L I++E+C L I + LF+E W LF +IV ++ +H+ G++HRD+K +NI
Sbjct: 156 LLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLF-QIVSAVSCIHKAGILHRDIKTLNI 214
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVI 832
FL + +K+GD+GLA K + + +L +GT Y++PEL Q V
Sbjct: 215 FLTKANLIKLGDYGLAKKL---------NSEYSMAETL---VGTPYYMSPELCQG---VK 259
Query: 833 YNQKVDIYSLGIILFEMFHPPLETGMERMMVLTNLRSKDIVIPNKFDVDE---NVKQIHV 889
YN K DI+++G ++FE+ L+ + L NL K + +VD +++ I +
Sbjct: 260 YNFKSDIWAVGCVIFELL--TLKRTFDATNPL-NLCVKIVQGIRAMEVDSSQYSLELIQM 316
Query: 890 IRWLLNHEASLRPTCAELL 908
+ L+ + RPT ELL
Sbjct: 317 VHSCLDQDPEQRPTADELL 335
Score = 48.8 bits (111), Expect = 2e-04
Identities = 23/72 (31%), Positives = 39/72 (54%)
Query: 542 LGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENVVRYYNA 601
LG+GAFG+ + D K V L S + + E+ +L+ L H+N++ YYN
Sbjct: 90 LGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNH 149
Query: 602 WIESTTEPIDCE 613
++++TT I+ E
Sbjct: 150 FMDNTTLLIELE 161
Score = 36.3 bits (80), Expect = 0.87
Identities = 35/139 (25%), Positives = 65/139 (46%), Gaps = 16/139 (11%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRL------AEMLDNDNY--- 425
++SA++ +H A I+HRD+++ N+F+ +KL L +L AE L Y
Sbjct: 192 IVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMS 251
Query: 426 ---CD--KQTPAQDIYATGQLLLSIVCKEKSYTEIPQELPCVAKDFISRCLTEDEHSQWS 480
C K DI+A G ++ ++ ++++ + L K E + SQ+S
Sbjct: 252 PELCQGVKYNFKSDIWAVGCVIFELLTLKRTF-DATNPLNLCVKIVQGIRAMEVDSSQYS 310
Query: 481 AKQL-MSHYFLVEAPTKKP 498
+ + M H L + P ++P
Sbjct: 311 LELIQMVHSCLDQDPEQRP 329
>AK131198-1|BAD18393.1| 706|Homo sapiens protein ( Homo sapiens
cDNA FLJ16039 fis, clone ADRGL2001554, weakly similar
to SERINE/THREONINE-PROTEIN KINASE PLK (EC 2.7.1.-). ).
Length = 706
Score = 81.0 bits (191), Expect = 3e-14
Identities = 60/194 (30%), Positives = 96/194 (49%), Gaps = 16/194 (8%)
Query: 717 YIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDS 776
Y+ +E C TL + +I++ ++++H+R +IHRDLK NIFLD
Sbjct: 113 YLILELCSNETLAHLLRVRECLTEPEVQYFLLQIIDAVSYLHKRCIIHRDLKLGNIFLDE 172
Query: 777 NDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQK 836
N VK+GD GLA A P E K GT Y+APE+LQS K Y+ +
Sbjct: 173 NLEVKVGDLGLA--AQLNEPNERKKT----------MCGTPNYIAPEILQSNDKRAYSYE 220
Query: 837 VDIYSLGIILFEMF--HPPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLL 894
VDI+++G+I + M P + G + + +R ++ P K D + + IR +L
Sbjct: 221 VDIWAVGVITYTMLIGKAPFDGG-SKEITYRKIRENELSFPIK-DHHISHQARMFIRSIL 278
Query: 895 NHEASLRPTCAELL 908
N + + R T +++
Sbjct: 279 NPDPTQRLTLEQMV 292
Score = 35.5 bits (78), Expect = 1.5
Identities = 26/78 (33%), Positives = 40/78 (51%), Gaps = 4/78 (5%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAEMLDNDNYCDKQTPAQD 434
++ A++ LH IIHRD++ N+F+D+ +VK VG D LA L+ N K
Sbjct: 146 IIDAVSYLHKRCIIHRDLKLGNIFLDENLEVK-VG---DLGLAAQLNEPNERKKTMCGTP 201
Query: 435 IYATGQLLLSIVCKEKSY 452
Y ++L S + SY
Sbjct: 202 NYIAPEILQSNDKRAYSY 219
>L19559-1|AAA36659.1| 603|Homo sapiens protein kinase protein.
Length = 603
Score = 79.4 bits (187), Expect = 9e-14
Identities = 62/200 (31%), Positives = 102/200 (51%), Gaps = 26/200 (13%)
Query: 716 LYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLD 775
+++ +E C + +L + A R+IV G ++H+ +IHRDLK N+FL+
Sbjct: 126 VFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN 185
Query: 776 SNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQ 835
+ VKIGDFGLATK E G GT Y+APE+L +K ++
Sbjct: 186 EDLEVKIGDFGLATKV------------EYDGERKKTLCGTPNYIAPEVL---SKKGHSF 230
Query: 836 KVDIYSLGIILFEMF--HPPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQI--HVIR 891
+VD++S+G I++ + PP ET + T LR K N++ + +++ + +I+
Sbjct: 231 EVDVWSIGCIMYTLLVGKPPFETS---CLKETYLRIK----KNEYSIPKHINPVAASLIQ 283
Query: 892 WLLNHEASLRPTCAELLASE 911
+L + + RPT ELL E
Sbjct: 284 KMLQTDPTARPTINELLGDE 303
>X75932-1|CAA53536.1| 603|Homo sapiens Serine/Threonine protein
kinase protein.
Length = 603
Score = 79.0 bits (186), Expect = 1e-13
Identities = 62/200 (31%), Positives = 102/200 (51%), Gaps = 26/200 (13%)
Query: 716 LYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLD 775
+++ +E C + +L + A R+IV G ++H+ +IHRDLK N+FL+
Sbjct: 126 VFVVLELCRRRSLLEPHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN 185
Query: 776 SNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQ 835
+ VKIGDFGLATK E G GT Y+APE+L +K ++
Sbjct: 186 EDLEVKIGDFGLATKV------------EYDGERKKTLCGTPNYIAPEVL---SKKEHSF 230
Query: 836 KVDIYSLGIILFEMF--HPPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQI--HVIR 891
+VD++S+G I++ + PP ET + T LR K N++ + +++ + +I+
Sbjct: 231 EVDVWSIGCIMYTLLVGKPPFETS---CLKETYLRIK----KNEYSIPKHINPVAASLIQ 283
Query: 892 WLLNHEASLRPTCAELLASE 911
+L + + RPT ELL E
Sbjct: 284 KMLQTDPTARPTINELLNDE 303
>X73458-1|CAA51837.1| 603|Homo sapiens protein kinase protein.
Length = 603
Score = 78.6 bits (185), Expect = 2e-13
Identities = 62/200 (31%), Positives = 102/200 (51%), Gaps = 26/200 (13%)
Query: 716 LYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLD 775
+++ +E C + +L + A R+IV G ++H+ +IHRDLK N+FL+
Sbjct: 126 VFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN 185
Query: 776 SNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQ 835
+ VKIGDFGLATK E G GT Y+APE+L +K ++
Sbjct: 186 EDLEVKIGDFGLATKV------------EYDGERKKTLCGTPNYIAPEVL---SKKGHSF 230
Query: 836 KVDIYSLGIILFEMF--HPPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQI--HVIR 891
+VD++S+G I++ + PP ET + T LR K N++ + +++ + +I+
Sbjct: 231 EVDVWSIGCIMYTLLVGKPPFETS---CLKETYLRIK----KNEYSIPKHINPVAASLIQ 283
Query: 892 WLLNHEASLRPTCAELLASE 911
+L + + RPT ELL E
Sbjct: 284 KMLQTDPTARPTINELLNDE 303
>U01038-1|AAA56634.1| 603|Homo sapiens pLK protein.
Length = 603
Score = 78.6 bits (185), Expect = 2e-13
Identities = 62/200 (31%), Positives = 102/200 (51%), Gaps = 26/200 (13%)
Query: 716 LYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLD 775
+++ +E C + +L + A R+IV G ++H+ +IHRDLK N+FL+
Sbjct: 126 VFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN 185
Query: 776 SNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQ 835
+ VKIGDFGLATK E G GT Y+APE+L +K ++
Sbjct: 186 EDLEVKIGDFGLATKV------------EYDGERKKTLCGTPNYIAPEVL---SKKGHSF 230
Query: 836 KVDIYSLGIILFEMF--HPPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQI--HVIR 891
+VD++S+G I++ + PP ET + T LR K N++ + +++ + +I+
Sbjct: 231 EVDVWSIGCIMYTLLVGKPPFETS---CLKETYLRIK----KNEYSIPKHINPVAASLIQ 283
Query: 892 WLLNHEASLRPTCAELLASE 911
+L + + RPT ELL E
Sbjct: 284 KMLQTDPTARPTINELLNDE 303
>BC014846-1|AAH14846.1| 603|Homo sapiens polo-like kinase 1
(Drosophila) protein.
Length = 603
Score = 78.6 bits (185), Expect = 2e-13
Identities = 62/200 (31%), Positives = 102/200 (51%), Gaps = 26/200 (13%)
Query: 716 LYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLD 775
+++ +E C + +L + A R+IV G ++H+ +IHRDLK N+FL+
Sbjct: 126 VFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN 185
Query: 776 SNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQ 835
+ VKIGDFGLATK E G GT Y+APE+L +K ++
Sbjct: 186 EDLEVKIGDFGLATKV------------EYDGERKKTLCGTPNYIAPEVL---SKKGHSF 230
Query: 836 KVDIYSLGIILFEMF--HPPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQI--HVIR 891
+VD++S+G I++ + PP ET + T LR K N++ + +++ + +I+
Sbjct: 231 EVDVWSIGCIMYTLLVGKPPFETS---CLKETYLRIK----KNEYSIPKHINPVAASLIQ 283
Query: 892 WLLNHEASLRPTCAELLASE 911
+L + + RPT ELL E
Sbjct: 284 KMLQTDPTARPTINELLNDE 303
>BC003002-1|AAH03002.1| 603|Homo sapiens polo-like kinase 1
(Drosophila) protein.
Length = 603
Score = 78.6 bits (185), Expect = 2e-13
Identities = 62/200 (31%), Positives = 102/200 (51%), Gaps = 26/200 (13%)
Query: 716 LYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLD 775
+++ +E C + +L + A R+IV G ++H+ +IHRDLK N+FL+
Sbjct: 126 VFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN 185
Query: 776 SNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQ 835
+ VKIGDFGLATK E G GT Y+APE+L +K ++
Sbjct: 186 EDLEVKIGDFGLATKV------------EYDGERKKTLCGTPNYIAPEVL---SKKGHSF 230
Query: 836 KVDIYSLGIILFEMF--HPPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQI--HVIR 891
+VD++S+G I++ + PP ET + T LR K N++ + +++ + +I+
Sbjct: 231 EVDVWSIGCIMYTLLVGKPPFETS---CLKETYLRIK----KNEYSIPKHINPVAASLIQ 283
Query: 892 WLLNHEASLRPTCAELLASE 911
+L + + RPT ELL E
Sbjct: 284 KMLQTDPTARPTINELLNDE 303
>BC002369-1|AAH02369.1| 603|Homo sapiens polo-like kinase 1
(Drosophila) protein.
Length = 603
Score = 78.6 bits (185), Expect = 2e-13
Identities = 62/200 (31%), Positives = 102/200 (51%), Gaps = 26/200 (13%)
Query: 716 LYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLD 775
+++ +E C + +L + A R+IV G ++H+ +IHRDLK N+FL+
Sbjct: 126 VFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN 185
Query: 776 SNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQ 835
+ VKIGDFGLATK E G GT Y+APE+L +K ++
Sbjct: 186 EDLEVKIGDFGLATKV------------EYDGERKKTLCGTPNYIAPEVL---SKKGHSF 230
Query: 836 KVDIYSLGIILFEMF--HPPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQI--HVIR 891
+VD++S+G I++ + PP ET + T LR K N++ + +++ + +I+
Sbjct: 231 EVDVWSIGCIMYTLLVGKPPFETS---CLKETYLRIK----KNEYSIPKHINPVAASLIQ 283
Query: 892 WLLNHEASLRPTCAELLASE 911
+L + + RPT ELL E
Sbjct: 284 KMLQTDPTARPTINELLNDE 303
>BC017575-1|AAH17575.1| 476|Homo sapiens CHK1 checkpoint homolog
(S. pombe) protein.
Length = 476
Score = 78.2 bits (184), Expect = 2e-13
Identities = 47/135 (34%), Positives = 73/135 (54%), Gaps = 12/135 (8%)
Query: 715 VLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
+ Y+ +E+C L I+ + A R F +++ G+ ++H G+ HRD+KP N+ L
Sbjct: 79 IQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLL 138
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
D D++KI DFGLAT V +E + L GT YVAPELL+ + +
Sbjct: 139 DERDNLKISDFGLAT-------VFRYNNRERL---LNKMCGTLPYVAPELLK--RREFHA 186
Query: 835 QKVDIYSLGIILFEM 849
+ VD++S GI+L M
Sbjct: 187 EPVDVWSCGIVLTAM 201
Score = 44.0 bits (99), Expect = 0.004
Identities = 21/65 (32%), Positives = 40/65 (61%), Gaps = 1/65 (1%)
Query: 535 EFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHEN 594
+++++ LG+GA+G+V N++ A+K V + +V + I +E+ + LNHEN
Sbjct: 8 DWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK-RAVDCPENIKKEICINKMLNHEN 66
Query: 595 VVRYY 599
VV++Y
Sbjct: 67 VVKFY 71
>BC004202-1|AAH04202.1| 476|Homo sapiens CHEK1 protein protein.
Length = 476
Score = 78.2 bits (184), Expect = 2e-13
Identities = 47/135 (34%), Positives = 73/135 (54%), Gaps = 12/135 (8%)
Query: 715 VLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
+ Y+ +E+C L I+ + A R F +++ G+ ++H G+ HRD+KP N+ L
Sbjct: 79 IQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLL 138
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
D D++KI DFGLAT V +E + L GT YVAPELL+ + +
Sbjct: 139 DERDNLKISDFGLAT-------VFRYNNRERL---LNKMCGTLPYVAPELLK--RREFHA 186
Query: 835 QKVDIYSLGIILFEM 849
+ VD++S GI+L M
Sbjct: 187 EPVDVWSCGIVLTAM 201
Score = 44.0 bits (99), Expect = 0.004
Identities = 21/65 (32%), Positives = 40/65 (61%), Gaps = 1/65 (1%)
Query: 535 EFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHEN 594
+++++ LG+GA+G+V N++ A+K V + +V + I +E+ + LNHEN
Sbjct: 8 DWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK-RAVDCPENIKKEICINKMLNHEN 66
Query: 595 VVRYY 599
VV++Y
Sbjct: 67 VVKFY 71
>AF527555-1|AAM78553.1| 476|Homo sapiens CHK1 checkpoint homolog
(S. pombe) protein.
Length = 476
Score = 78.2 bits (184), Expect = 2e-13
Identities = 47/135 (34%), Positives = 73/135 (54%), Gaps = 12/135 (8%)
Query: 715 VLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
+ Y+ +E+C L I+ + A R F +++ G+ ++H G+ HRD+KP N+ L
Sbjct: 79 IQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLL 138
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
D D++KI DFGLAT V +E + L GT YVAPELL+ + +
Sbjct: 139 DERDNLKISDFGLAT-------VFRYNNRERL---LNKMCGTLPYVAPELLK--RREFHA 186
Query: 835 QKVDIYSLGIILFEM 849
+ VD++S GI+L M
Sbjct: 187 EPVDVWSCGIVLTAM 201
Score = 44.0 bits (99), Expect = 0.004
Identities = 21/65 (32%), Positives = 40/65 (61%), Gaps = 1/65 (1%)
Query: 535 EFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHEN 594
+++++ LG+GA+G+V N++ A+K V + +V + I +E+ + LNHEN
Sbjct: 8 DWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK-RAVDCPENIKKEICINKMLNHEN 66
Query: 595 VVRYY 599
VV++Y
Sbjct: 67 VVKFY 71
>AF032874-1|AAB88852.1| 476|Homo sapiens protein kinase protein.
Length = 476
Score = 78.2 bits (184), Expect = 2e-13
Identities = 47/135 (34%), Positives = 73/135 (54%), Gaps = 12/135 (8%)
Query: 715 VLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
+ Y+ +E+C L I+ + A R F +++ G+ ++H G+ HRD+KP N+ L
Sbjct: 79 IQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLL 138
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
D D++KI DFGLAT V +E + L GT YVAPELL+ + +
Sbjct: 139 DERDNLKISDFGLAT-------VFRYNNRERL---LNKMCGTLPYVAPELLK--RREFHA 186
Query: 835 QKVDIYSLGIILFEM 849
+ VD++S GI+L M
Sbjct: 187 EPVDVWSCGIVLTAM 201
Score = 44.0 bits (99), Expect = 0.004
Identities = 21/65 (32%), Positives = 40/65 (61%), Gaps = 1/65 (1%)
Query: 535 EFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHEN 594
+++++ LG+GA+G+V N++ A+K V + +V + I +E+ + LNHEN
Sbjct: 8 DWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK-RAVDCPENIKKEICINKMLNHEN 66
Query: 595 VVRYY 599
VV++Y
Sbjct: 67 VVKFY 71
>AF016582-1|AAC51736.1| 476|Homo sapiens Chk1 protein.
Length = 476
Score = 78.2 bits (184), Expect = 2e-13
Identities = 47/135 (34%), Positives = 73/135 (54%), Gaps = 12/135 (8%)
Query: 715 VLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
+ Y+ +E+C L I+ + A R F +++ G+ ++H G+ HRD+KP N+ L
Sbjct: 79 IQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLL 138
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
D D++KI DFGLAT V +E + L GT YVAPELL+ + +
Sbjct: 139 DERDNLKISDFGLAT-------VFRYNNRERL---LNKMCGTLPYVAPELLK--RREFHA 186
Query: 835 QKVDIYSLGIILFEM 849
+ VD++S GI+L M
Sbjct: 187 EPVDVWSCGIVLTAM 201
Score = 44.0 bits (99), Expect = 0.004
Identities = 21/65 (32%), Positives = 40/65 (61%), Gaps = 1/65 (1%)
Query: 535 EFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHEN 594
+++++ LG+GA+G+V N++ A+K V + +V + I +E+ + LNHEN
Sbjct: 8 DWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK-RAVDCPENIKKEICINKMLNHEN 66
Query: 595 VVRYY 599
VV++Y
Sbjct: 67 VVKFY 71
>AB032387-1|BAA84577.1| 476|Homo sapiens checkpoint kinase protein.
Length = 476
Score = 78.2 bits (184), Expect = 2e-13
Identities = 47/135 (34%), Positives = 73/135 (54%), Gaps = 12/135 (8%)
Query: 715 VLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
+ Y+ +E+C L I+ + A R F +++ G+ ++H G+ HRD+KP N+ L
Sbjct: 79 IQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLL 138
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
D D++KI DFGLAT V +E + L GT YVAPELL+ + +
Sbjct: 139 DERDNLKISDFGLAT-------VFRYNNRERL---LNKMCGTLPYVAPELLK--RREFHA 186
Query: 835 QKVDIYSLGIILFEM 849
+ VD++S GI+L M
Sbjct: 187 EPVDVWSCGIVLTAM 201
Score = 44.0 bits (99), Expect = 0.004
Identities = 21/65 (32%), Positives = 40/65 (61%), Gaps = 1/65 (1%)
Query: 535 EFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHEN 594
+++++ LG+GA+G+V N++ A+K V + +V + I +E+ + LNHEN
Sbjct: 8 DWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK-RAVDCPENIKKEICINKMLNHEN 66
Query: 595 VVRYY 599
VV++Y
Sbjct: 67 VVKFY 71
>BC099843-1|AAH99843.1| 416|Homo sapiens serine/threonine protein
kinase MST4 protein.
Length = 416
Score = 77.4 bits (182), Expect = 4e-13
Identities = 63/199 (31%), Positives = 97/199 (48%), Gaps = 20/199 (10%)
Query: 716 LYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLD 775
L+I ME+ + + G F E F+ + +EI++GL ++H IHRD+K N+ L
Sbjct: 95 LWIIMEYLGGGSALDLLRAGPFDE-FQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLS 153
Query: 776 SNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQ 835
VK+ DFG+A G + + K+ +GT ++APE++Q + Y+
Sbjct: 154 EQGDVKLADFGVA-----GQLTDTQIKRNTF-------VGTPFWMAPEVIQQSA---YDS 198
Query: 836 KVDIYSLGIILFEMFH-PPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLL 894
K DI+SLGI E+ P + M M VL L K+ D E+ K+ I L
Sbjct: 199 KADIWSLGITAIELAKGEPPNSDMHPMRVLF-LIPKNNPPTLVGDFTESFKEF--IDACL 255
Query: 895 NHEASLRPTCAELLASEHV 913
N + S RPT ELL + +
Sbjct: 256 NKDPSFRPTAKELLKHKFI 274
Score = 42.3 bits (95), Expect = 0.013
Identities = 31/130 (23%), Positives = 66/130 (50%), Gaps = 14/130 (10%)
Query: 289 DFQTRNKQLTSIQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSL 348
D + ++ IQQ++ L++ ++ + Y + + SK ++I ++ G S
Sbjct: 56 DLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYL------KGSK--LWIIMEYLGGGSA 107
Query: 349 KNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLV 408
+L++ +G D F++ +L+ + G L+ LH+ IHRD+++ NV + + G VKL
Sbjct: 108 LDLLR--AGPFDEFQIATMLKEILKG----LDYLHSEKKIHRDIKAANVLLSEQGDVKLA 161
Query: 409 GASLDTRLAE 418
+ +L +
Sbjct: 162 DFGVAGQLTD 171
Score = 37.9 bits (84), Expect = 0.29
Identities = 21/80 (26%), Positives = 43/80 (53%), Gaps = 1/80 (1%)
Query: 527 NGLSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKL 586
N ++ + F L +GKG+FG+V K + AIK + L ++ + I +E+ +
Sbjct: 15 NNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEI-EDIQQEITV 73
Query: 587 LSRLNHENVVRYYNAWIEST 606
LS+ + V +YY ++++ +
Sbjct: 74 LSQCDSSYVTKYYGSYLKGS 93
Score = 33.5 bits (73), Expect = 6.2
Identities = 14/37 (37%), Positives = 23/37 (62%)
Query: 464 KDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTKKPYV 500
K+FI CL +D + +AK+L+ H F+V+ K Y+
Sbjct: 248 KEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYL 284
>Z11518-1|CAA77607.1| 509|Homo sapiens histidyl-tRNA synthetase
protein.
Length = 509
Score = 76.6 bits (180), Expect = 7e-13
Identities = 79/357 (22%), Positives = 160/357 (44%), Gaps = 29/357 (8%)
Query: 971 EFVKDAVVKVFKSHGALEFAPPLLIPRARAWDQYPNAVKVM----TSSGSVCHLPHDLRL 1026
E V D +++ FK HGA P+ + +Y K++ G + L +DL +
Sbjct: 74 EKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTV 133
Query: 1027 PFARHIAYSGIKNLRRFIVDRVYREKH---VQGFHPKEILECAYDIVTPKTDSLWPDAEL 1083
PFAR++A + + N++R+ + +VYR + +G + +E +C +DI D + PDAE
Sbjct: 134 PFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRY-REFYQCDFDI-AGNFDPMIPDAEC 191
Query: 1084 IEVASRAASECSL-KVSIQLNHTELIRVLLQSCGVPTDKQADI---YPVLVDVSFGRIXX 1139
+++ S + +++N ++ + CGV K I L VS+ +
Sbjct: 192 LKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKN 251
Query: 1140 XXXXXXXXXXCITNRDVTNLVRLMEADAPVQELRELVTPLVKQAKCSRIASQAVHDLEAV 1199
+ +R + + V+ + V++L L P + Q ++ A + + DL+ +
Sbjct: 252 EMVGEKGLAPEVADR-IGDYVQQHGGVSLVEQL--LQDPKLSQ---NKQALEGLGDLKLL 305
Query: 1200 YRNAKALGCECPMTVAPLSAYNVTQHSGVFWQMSVVRSEQKSITKRRSGDLIAAGGRYDA 1259
+ G + ++ A + ++GV ++ ++++ ++ + +AAGGRYD
Sbjct: 306 FEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDG 365
Query: 1260 LVKEFWNVASAENDQDSADLNVCSVGFSMSLERMAAFLNKLETQTNVPIKSNETPLV 1316
LV F D V VG S+ +ER+ + + + I++ ET ++
Sbjct: 366 LVGMF----------DPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVL 412
>BC080514-1|AAH80514.1| 509|Homo sapiens histidyl-tRNA synthetase
protein.
Length = 509
Score = 76.6 bits (180), Expect = 7e-13
Identities = 79/357 (22%), Positives = 160/357 (44%), Gaps = 29/357 (8%)
Query: 971 EFVKDAVVKVFKSHGALEFAPPLLIPRARAWDQYPNAVKVM----TSSGSVCHLPHDLRL 1026
E V D +++ FK HGA P+ + +Y K++ G + L +DL +
Sbjct: 74 EKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTV 133
Query: 1027 PFARHIAYSGIKNLRRFIVDRVYREKH---VQGFHPKEILECAYDIVTPKTDSLWPDAEL 1083
PFAR++A + + N++R+ + +VYR + +G + +E +C +DI D + PDAE
Sbjct: 134 PFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRY-REFYQCDFDI-AGNFDPMIPDAEC 191
Query: 1084 IEVASRAASECSL-KVSIQLNHTELIRVLLQSCGVPTDKQADI---YPVLVDVSFGRIXX 1139
+++ S + +++N ++ + CGV K I L VS+ +
Sbjct: 192 LKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKN 251
Query: 1140 XXXXXXXXXXCITNRDVTNLVRLMEADAPVQELRELVTPLVKQAKCSRIASQAVHDLEAV 1199
+ +R + + V+ + V++L L P + Q ++ A + + DL+ +
Sbjct: 252 EMVGEKGLAPEVADR-IGDYVQQHGGVSLVEQL--LQDPKLSQ---NKQALEGLGDLKLL 305
Query: 1200 YRNAKALGCECPMTVAPLSAYNVTQHSGVFWQMSVVRSEQKSITKRRSGDLIAAGGRYDA 1259
+ G + ++ A + ++GV ++ ++++ ++ + +AAGGRYD
Sbjct: 306 FEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDG 365
Query: 1260 LVKEFWNVASAENDQDSADLNVCSVGFSMSLERMAAFLNKLETQTNVPIKSNETPLV 1316
LV F D V VG S+ +ER+ + + + I++ ET ++
Sbjct: 366 LVGMF----------DPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVL 412
>BC011807-1|AAH11807.1| 509|Homo sapiens histidyl-tRNA synthetase
protein.
Length = 509
Score = 76.6 bits (180), Expect = 7e-13
Identities = 79/357 (22%), Positives = 160/357 (44%), Gaps = 29/357 (8%)
Query: 971 EFVKDAVVKVFKSHGALEFAPPLLIPRARAWDQYPNAVKVM----TSSGSVCHLPHDLRL 1026
E V D +++ FK HGA P+ + +Y K++ G + L +DL +
Sbjct: 74 EKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTV 133
Query: 1027 PFARHIAYSGIKNLRRFIVDRVYREKH---VQGFHPKEILECAYDIVTPKTDSLWPDAEL 1083
PFAR++A + + N++R+ + +VYR + +G + +E +C +DI D + PDAE
Sbjct: 134 PFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRY-REFYQCDFDI-AGNFDPMIPDAEC 191
Query: 1084 IEVASRAASECSL-KVSIQLNHTELIRVLLQSCGVPTDKQADI---YPVLVDVSFGRIXX 1139
+++ S + +++N ++ + CGV K I L VS+ +
Sbjct: 192 LKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKN 251
Query: 1140 XXXXXXXXXXCITNRDVTNLVRLMEADAPVQELRELVTPLVKQAKCSRIASQAVHDLEAV 1199
+ +R + + V+ + V++L L P + Q ++ A + + DL+ +
Sbjct: 252 EMVGEKGLAPEVADR-IGDYVQQHGGVSLVEQL--LQDPKLSQ---NKQALEGLGDLKLL 305
Query: 1200 YRNAKALGCECPMTVAPLSAYNVTQHSGVFWQMSVVRSEQKSITKRRSGDLIAAGGRYDA 1259
+ G + ++ A + ++GV ++ ++++ ++ + +AAGGRYD
Sbjct: 306 FEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDG 365
Query: 1260 LVKEFWNVASAENDQDSADLNVCSVGFSMSLERMAAFLNKLETQTNVPIKSNETPLV 1316
LV F D V VG S+ +ER+ + + + I++ ET ++
Sbjct: 366 LVGMF----------DPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVL 412
>BT020099-1|AAV38902.1| 416|Homo sapiens Mst3 and SOK1-related
kinase protein.
Length = 416
Score = 75.8 bits (178), Expect = 1e-12
Identities = 62/199 (31%), Positives = 97/199 (48%), Gaps = 20/199 (10%)
Query: 716 LYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLD 775
L+I ME+ + + G F E F+ + +EI++GL ++H IHRD+K N+ L
Sbjct: 95 LWIIMEYLGGGSALDLLRAGPFDE-FQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLS 153
Query: 776 SNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQ 835
VK+ DFG+A G + + K+ +GT ++APE++Q + Y+
Sbjct: 154 EQGDVKLADFGVA-----GQLTDTQIKRNTF-------VGTPFWMAPEVIQQSA---YDS 198
Query: 836 KVDIYSLGIILFEMFH-PPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLL 894
K DI+SLGI E+ P + M M VL L K+ D ++ K+ I L
Sbjct: 199 KADIWSLGITAIELAKGEPPNSDMHPMRVLF-LIPKNNPPTLVGDFTKSFKEF--IDACL 255
Query: 895 NHEASLRPTCAELLASEHV 913
N + S RPT ELL + +
Sbjct: 256 NKDPSFRPTAKELLKHKFI 274
Score = 42.3 bits (95), Expect = 0.013
Identities = 31/130 (23%), Positives = 66/130 (50%), Gaps = 14/130 (10%)
Query: 289 DFQTRNKQLTSIQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSL 348
D + ++ IQQ++ L++ ++ + Y + + SK ++I ++ G S
Sbjct: 56 DLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYL------KGSK--LWIIMEYLGGGSA 107
Query: 349 KNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLV 408
+L++ +G D F++ +L+ + G L+ LH+ IHRD+++ NV + + G VKL
Sbjct: 108 LDLLR--AGPFDEFQIATMLKEILKG----LDYLHSEKKIHRDIKAANVLLSEQGDVKLA 161
Query: 409 GASLDTRLAE 418
+ +L +
Sbjct: 162 DFGVAGQLTD 171
Score = 37.9 bits (84), Expect = 0.29
Identities = 21/80 (26%), Positives = 43/80 (53%), Gaps = 1/80 (1%)
Query: 527 NGLSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKL 586
N ++ + F L +GKG+FG+V K + AIK + L ++ + I +E+ +
Sbjct: 15 NNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEI-EDIQQEITV 73
Query: 587 LSRLNHENVVRYYNAWIEST 606
LS+ + V +YY ++++ +
Sbjct: 74 LSQCDSSYVTKYYGSYLKGS 93
Score = 33.5 bits (73), Expect = 6.2
Identities = 14/37 (37%), Positives = 23/37 (62%)
Query: 464 KDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTKKPYV 500
K+FI CL +D + +AK+L+ H F+V+ K Y+
Sbjct: 248 KEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYL 284
>BC103503-1|AAI03504.1| 416|Homo sapiens serine/threonine protein
kinase MST4 protein.
Length = 416
Score = 75.8 bits (178), Expect = 1e-12
Identities = 62/199 (31%), Positives = 97/199 (48%), Gaps = 20/199 (10%)
Query: 716 LYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLD 775
L+I ME+ + + G F E F+ + +EI++GL ++H IHRD+K N+ L
Sbjct: 95 LWIIMEYLGGGSALDLLRAGPFDE-FQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLS 153
Query: 776 SNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQ 835
VK+ DFG+A G + + K+ +GT ++APE++Q + Y+
Sbjct: 154 EQGDVKLADFGVA-----GQLTDTQIKRNTF-------VGTPFWMAPEVIQQSA---YDS 198
Query: 836 KVDIYSLGIILFEMFH-PPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLL 894
K DI+SLGI E+ P + M M VL L K+ D ++ K+ I L
Sbjct: 199 KADIWSLGITAIELAKGEPPNSDMHPMRVLF-LIPKNNPPTLVGDFTKSFKEF--IDACL 255
Query: 895 NHEASLRPTCAELLASEHV 913
N + S RPT ELL + +
Sbjct: 256 NKDPSFRPTAKELLKHKFI 274
Score = 42.3 bits (95), Expect = 0.013
Identities = 31/130 (23%), Positives = 66/130 (50%), Gaps = 14/130 (10%)
Query: 289 DFQTRNKQLTSIQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSL 348
D + ++ IQQ++ L++ ++ + Y + + SK ++I ++ G S
Sbjct: 56 DLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYL------KGSK--LWIIMEYLGGGSA 107
Query: 349 KNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLV 408
+L++ +G D F++ +L+ + G L+ LH+ IHRD+++ NV + + G VKL
Sbjct: 108 LDLLR--AGPFDEFQIATMLKEILKG----LDYLHSEKKIHRDIKAANVLLSEQGDVKLA 161
Query: 409 GASLDTRLAE 418
+ +L +
Sbjct: 162 DFGVAGQLTD 171
Score = 37.9 bits (84), Expect = 0.29
Identities = 21/80 (26%), Positives = 43/80 (53%), Gaps = 1/80 (1%)
Query: 527 NGLSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKL 586
N ++ + F L +GKG+FG+V K + AIK + L ++ + I +E+ +
Sbjct: 15 NNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEI-EDIQQEITV 73
Query: 587 LSRLNHENVVRYYNAWIEST 606
LS+ + V +YY ++++ +
Sbjct: 74 LSQCDSSYVTKYYGSYLKGS 93
Score = 33.5 bits (73), Expect = 6.2
Identities = 14/37 (37%), Positives = 23/37 (62%)
Query: 464 KDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTKKPYV 500
K+FI CL +D + +AK+L+ H F+V+ K Y+
Sbjct: 248 KEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYL 284
>BC098315-1|AAH98315.1| 416|Homo sapiens serine/threonine protein
kinase MST4 protein.
Length = 416
Score = 75.8 bits (178), Expect = 1e-12
Identities = 62/199 (31%), Positives = 97/199 (48%), Gaps = 20/199 (10%)
Query: 716 LYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLD 775
L+I ME+ + + G F E F+ + +EI++GL ++H IHRD+K N+ L
Sbjct: 95 LWIIMEYLGGGSALDLLRAGPFDE-FQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLS 153
Query: 776 SNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQ 835
VK+ DFG+A G + + K+ +GT ++APE++Q + Y+
Sbjct: 154 EQGDVKLADFGVA-----GQLTDTQIKRNTF-------VGTPFWMAPEVIQQSA---YDS 198
Query: 836 KVDIYSLGIILFEMFH-PPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLL 894
K DI+SLGI E+ P + M M VL L K+ D ++ K+ I L
Sbjct: 199 KADIWSLGITAIELAKGEPPNSDMHPMRVLF-LIPKNNPPTLVGDFTKSFKEF--IDACL 255
Query: 895 NHEASLRPTCAELLASEHV 913
N + S RPT ELL + +
Sbjct: 256 NKDPSFRPTAKELLKHKFI 274
Score = 42.3 bits (95), Expect = 0.013
Identities = 31/130 (23%), Positives = 66/130 (50%), Gaps = 14/130 (10%)
Query: 289 DFQTRNKQLTSIQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSL 348
D + ++ IQQ++ L++ ++ + Y + + SK ++I ++ G S
Sbjct: 56 DLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYL------KGSK--LWIIMEYLGGGSA 107
Query: 349 KNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLV 408
+L++ +G D F++ +L+ + G L+ LH+ IHRD+++ NV + + G VKL
Sbjct: 108 LDLLR--AGPFDEFQIATMLKEILKG----LDYLHSEKKIHRDIKAANVLLSEQGDVKLA 161
Query: 409 GASLDTRLAE 418
+ +L +
Sbjct: 162 DFGVAGQLTD 171
Score = 37.9 bits (84), Expect = 0.29
Identities = 21/80 (26%), Positives = 43/80 (53%), Gaps = 1/80 (1%)
Query: 527 NGLSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKL 586
N ++ + F L +GKG+FG+V K + AIK + L ++ + I +E+ +
Sbjct: 15 NNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEI-EDIQQEITV 73
Query: 587 LSRLNHENVVRYYNAWIEST 606
LS+ + V +YY ++++ +
Sbjct: 74 LSQCDSSYVTKYYGSYLKGS 93
Score = 33.5 bits (73), Expect = 6.2
Identities = 14/37 (37%), Positives = 23/37 (62%)
Query: 464 KDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTKKPYV 500
K+FI CL +D + +AK+L+ H F+V+ K Y+
Sbjct: 248 KEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYL 284
>AL109749-1|CAI42079.1| 416|Homo sapiens Mst3 and SOK1-related
kinase (MST4) protein.
Length = 416
Score = 75.8 bits (178), Expect = 1e-12
Identities = 62/199 (31%), Positives = 97/199 (48%), Gaps = 20/199 (10%)
Query: 716 LYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLD 775
L+I ME+ + + G F E F+ + +EI++GL ++H IHRD+K N+ L
Sbjct: 95 LWIIMEYLGGGSALDLLRAGPFDE-FQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLS 153
Query: 776 SNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQ 835
VK+ DFG+A G + + K+ +GT ++APE++Q + Y+
Sbjct: 154 EQGDVKLADFGVA-----GQLTDTQIKRNTF-------VGTPFWMAPEVIQQSA---YDS 198
Query: 836 KVDIYSLGIILFEMFH-PPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLL 894
K DI+SLGI E+ P + M M VL L K+ D ++ K+ I L
Sbjct: 199 KADIWSLGITAIELAKGEPPNSDMHPMRVLF-LIPKNNPPTLVGDFTKSFKEF--IDACL 255
Query: 895 NHEASLRPTCAELLASEHV 913
N + S RPT ELL + +
Sbjct: 256 NKDPSFRPTAKELLKHKFI 274
Score = 42.3 bits (95), Expect = 0.013
Identities = 31/130 (23%), Positives = 66/130 (50%), Gaps = 14/130 (10%)
Query: 289 DFQTRNKQLTSIQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSL 348
D + ++ IQQ++ L++ ++ + Y + + SK ++I ++ G S
Sbjct: 56 DLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYL------KGSK--LWIIMEYLGGGSA 107
Query: 349 KNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLV 408
+L++ +G D F++ +L+ + G L+ LH+ IHRD+++ NV + + G VKL
Sbjct: 108 LDLLR--AGPFDEFQIATMLKEILKG----LDYLHSEKKIHRDIKAANVLLSEQGDVKLA 161
Query: 409 GASLDTRLAE 418
+ +L +
Sbjct: 162 DFGVAGQLTD 171
Score = 37.9 bits (84), Expect = 0.29
Identities = 21/80 (26%), Positives = 43/80 (53%), Gaps = 1/80 (1%)
Query: 527 NGLSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKL 586
N ++ + F L +GKG+FG+V K + AIK + L ++ + I +E+ +
Sbjct: 15 NNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEI-EDIQQEITV 73
Query: 587 LSRLNHENVVRYYNAWIEST 606
LS+ + V +YY ++++ +
Sbjct: 74 LSQCDSSYVTKYYGSYLKGS 93
Score = 33.5 bits (73), Expect = 6.2
Identities = 14/37 (37%), Positives = 23/37 (62%)
Query: 464 KDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTKKPYV 500
K+FI CL +D + +AK+L+ H F+V+ K Y+
Sbjct: 248 KEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYL 284
>AK075150-1|BAC11435.1| 392|Homo sapiens protein ( Homo sapiens
cDNA FLJ90669 fis, clone PLACE1005519, moderately
similar to Homo sapiens STE20-like kinase 3 (mst-3)
mRNA. ).
Length = 392
Score = 75.8 bits (178), Expect = 1e-12
Identities = 62/199 (31%), Positives = 97/199 (48%), Gaps = 20/199 (10%)
Query: 716 LYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLD 775
L+I ME+ + + G F E F+ + +EI++GL ++H IHRD+K N+ L
Sbjct: 95 LWIIMEYLGGGSALDLLRAGPFDE-FQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLS 153
Query: 776 SNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQ 835
VK+ DFG+A G + + K+ +GT ++APE++Q + Y+
Sbjct: 154 EQGDVKLADFGVA-----GQLTDTQIKRNTF-------VGTPFWMAPEVIQQSA---YDS 198
Query: 836 KVDIYSLGIILFEMFH-PPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLL 894
K DI+SLGI E+ P + M M VL L K+ D ++ K+ I L
Sbjct: 199 KADIWSLGITAIELAKGEPPNSDMHPMRVLF-LIPKNNPPTLVGDFTKSFKEF--IDACL 255
Query: 895 NHEASLRPTCAELLASEHV 913
N + S RPT ELL + +
Sbjct: 256 NKDPSFRPTAKELLKHKFI 274
Score = 42.3 bits (95), Expect = 0.013
Identities = 31/130 (23%), Positives = 66/130 (50%), Gaps = 14/130 (10%)
Query: 289 DFQTRNKQLTSIQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSL 348
D + ++ IQQ++ L++ ++ + Y + + SK ++I ++ G S
Sbjct: 56 DLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYL------KGSK--LWIIMEYLGGGSA 107
Query: 349 KNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLV 408
+L++ +G D F++ +L+ + G L+ LH+ IHRD+++ NV + + G VKL
Sbjct: 108 LDLLR--AGPFDEFQIATMLKEILKG----LDYLHSEKKIHRDIKAANVLLSEQGDVKLA 161
Query: 409 GASLDTRLAE 418
+ +L +
Sbjct: 162 DFGVAGQLTD 171
Score = 37.9 bits (84), Expect = 0.29
Identities = 21/80 (26%), Positives = 43/80 (53%), Gaps = 1/80 (1%)
Query: 527 NGLSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKL 586
N ++ + F L +GKG+FG+V K + AIK + L ++ + I +E+ +
Sbjct: 15 NNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEI-EDIQQEITV 73
Query: 587 LSRLNHENVVRYYNAWIEST 606
LS+ + V +YY ++++ +
Sbjct: 74 LSQCDSSYVTKYYGSYLKGS 93
Score = 33.5 bits (73), Expect = 6.2
Identities = 14/37 (37%), Positives = 23/37 (62%)
Query: 464 KDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTKKPYV 500
K+FI CL +D + +AK+L+ H F+V+ K Y+
Sbjct: 248 KEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYL 284
>AK075107-1|BAC11406.1| 339|Homo sapiens protein ( Homo sapiens
cDNA FLJ90626 fis, clone PLACE1003135, weakly similar to
SPORULATION-SPECIFIC PROTEIN 1 (EC 2.7.1.-). ).
Length = 339
Score = 75.8 bits (178), Expect = 1e-12
Identities = 62/199 (31%), Positives = 97/199 (48%), Gaps = 20/199 (10%)
Query: 716 LYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLD 775
L+I ME+ + + G F E F+ + +EI++GL ++H IHRD+K N+ L
Sbjct: 18 LWIIMEYLGGGSALDLLRAGPFDE-FQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLS 76
Query: 776 SNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQ 835
VK+ DFG+A G + + K+ +GT ++APE++Q + Y+
Sbjct: 77 EQGDVKLADFGVA-----GQLTDTQIKRNTF-------VGTPFWMAPEVIQQSA---YDS 121
Query: 836 KVDIYSLGIILFEMFH-PPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLL 894
K DI+SLGI E+ P + M M VL L K+ D ++ K+ I L
Sbjct: 122 KADIWSLGITAIELAKGEPPNSDMHPMRVLF-LIPKNNPPTLVGDFTKSFKEF--IDACL 178
Query: 895 NHEASLRPTCAELLASEHV 913
N + S RPT ELL + +
Sbjct: 179 NKDPSFRPTAKELLKHKFI 197
Score = 39.1 bits (87), Expect = 0.12
Identities = 23/83 (27%), Positives = 46/83 (55%), Gaps = 6/83 (7%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
++I ++ G S +L++ +G D F++ +L+ + G L+ LH+ IHRD+++
Sbjct: 18 LWIIMEYLGGGSALDLLR--AGPFDEFQIATMLKEILKG----LDYLHSEKKIHRDIKAA 71
Query: 396 NVFVDDVGQVKLVGASLDTRLAE 418
NV + + G VKL + +L +
Sbjct: 72 NVLLSEQGDVKLADFGVAGQLTD 94
Score = 33.5 bits (73), Expect = 6.2
Identities = 14/37 (37%), Positives = 23/37 (62%)
Query: 464 KDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTKKPYV 500
K+FI CL +D + +AK+L+ H F+V+ K Y+
Sbjct: 171 KEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYL 207
>AF344882-1|AAK29620.1| 416|Homo sapiens serine/threonine protein
kinase MST4 protein.
Length = 416
Score = 75.8 bits (178), Expect = 1e-12
Identities = 62/199 (31%), Positives = 97/199 (48%), Gaps = 20/199 (10%)
Query: 716 LYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLD 775
L+I ME+ + + G F E F+ + +EI++GL ++H IHRD+K N+ L
Sbjct: 95 LWIIMEYLGGGSALDLLRAGPFDE-FQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLS 153
Query: 776 SNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQ 835
VK+ DFG+A G + + K+ +GT ++APE++Q + Y+
Sbjct: 154 EQGDVKLADFGVA-----GQLTDTQIKRNTF-------VGTPFWMAPEVIQQSA---YDS 198
Query: 836 KVDIYSLGIILFEMFH-PPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLL 894
K DI+SLGI E+ P + M M VL L K+ D ++ K+ I L
Sbjct: 199 KADIWSLGITAIELAKGEPPNSDMHPMRVLF-LIPKNNPPTLVGDFTKSFKEF--IDACL 255
Query: 895 NHEASLRPTCAELLASEHV 913
N + S RPT ELL + +
Sbjct: 256 NKDPSFRPTAKELLKHKFI 274
Score = 42.3 bits (95), Expect = 0.013
Identities = 31/130 (23%), Positives = 66/130 (50%), Gaps = 14/130 (10%)
Query: 289 DFQTRNKQLTSIQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSL 348
D + ++ IQQ++ L++ ++ + Y + + SK ++I ++ G S
Sbjct: 56 DLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYL------KGSK--LWIIMEYLGGGSA 107
Query: 349 KNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLV 408
+L++ +G D F++ +L+ + G L+ LH+ IHRD+++ NV + + G VKL
Sbjct: 108 LDLLR--AGPFDEFQIATMLKEILKG----LDYLHSEKKIHRDIKAANVLLSEQGDVKLA 161
Query: 409 GASLDTRLAE 418
+ +L +
Sbjct: 162 DFGVAGQLTD 171
Score = 37.9 bits (84), Expect = 0.29
Identities = 21/80 (26%), Positives = 43/80 (53%), Gaps = 1/80 (1%)
Query: 527 NGLSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKL 586
N ++ + F L +GKG+FG+V K + AIK + L ++ + I +E+ +
Sbjct: 15 NNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEI-EDIQQEITV 73
Query: 587 LSRLNHENVVRYYNAWIEST 606
LS+ + V +YY ++++ +
Sbjct: 74 LSQCDSSYVTKYYGSYLKGS 93
Score = 33.5 bits (73), Expect = 6.2
Identities = 14/37 (37%), Positives = 23/37 (62%)
Query: 464 KDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTKKPYV 500
K+FI CL +D + +AK+L+ H F+V+ K Y+
Sbjct: 248 KEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYL 284
>AF231012-1|AAK38484.1| 416|Homo sapiens STE20-like kinase MST4
protein.
Length = 416
Score = 75.8 bits (178), Expect = 1e-12
Identities = 62/199 (31%), Positives = 97/199 (48%), Gaps = 20/199 (10%)
Query: 716 LYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLD 775
L+I ME+ + + G F E F+ + +EI++GL ++H IHRD+K N+ L
Sbjct: 95 LWIIMEYLGGGSALDLLRAGPFDE-FQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLS 153
Query: 776 SNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQ 835
VK+ DFG+A G + + K+ +GT ++APE++Q + Y+
Sbjct: 154 EQGDVKLADFGVA-----GQLTDTQIKRNTF-------VGTPFWMAPEVIQQSA---YDS 198
Query: 836 KVDIYSLGIILFEMFH-PPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLL 894
K DI+SLGI E+ P + M M VL L K+ D ++ K+ I L
Sbjct: 199 KADIWSLGITAIELAKGEPPNSDMHPMRVLF-LIPKNNPPTLVGDFTKSFKEF--IDACL 255
Query: 895 NHEASLRPTCAELLASEHV 913
N + S RPT ELL + +
Sbjct: 256 NKDPSFRPTAKELLKHKFI 274
Score = 42.3 bits (95), Expect = 0.013
Identities = 31/130 (23%), Positives = 66/130 (50%), Gaps = 14/130 (10%)
Query: 289 DFQTRNKQLTSIQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSL 348
D + ++ IQQ++ L++ ++ + Y + + SK ++I ++ G S
Sbjct: 56 DLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYL------KGSK--LWIIMEYLGGGSA 107
Query: 349 KNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLV 408
+L++ +G D F++ +L+ + G L+ LH+ IHRD+++ NV + + G VKL
Sbjct: 108 LDLLR--AGPFDEFQIATMLKEILKG----LDYLHSEKKIHRDIKAANVLLSEQGDVKLA 161
Query: 409 GASLDTRLAE 418
+ +L +
Sbjct: 162 DFGVAGQLTD 171
Score = 37.9 bits (84), Expect = 0.29
Identities = 21/80 (26%), Positives = 43/80 (53%), Gaps = 1/80 (1%)
Query: 527 NGLSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKL 586
N ++ + F L +GKG+FG+V K + AIK + L ++ + I +E+ +
Sbjct: 15 NNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEI-EDIQQEITV 73
Query: 587 LSRLNHENVVRYYNAWIEST 606
LS+ + V +YY ++++ +
Sbjct: 74 LSQCDSSYVTKYYGSYLKGS 93
Score = 33.5 bits (73), Expect = 6.2
Identities = 14/37 (37%), Positives = 23/37 (62%)
Query: 464 KDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTKKPYV 500
K+FI CL +D + +AK+L+ H F+V+ K Y+
Sbjct: 248 KEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYL 284
>AB040057-1|BAA92785.2| 416|Homo sapiens serine/threonine protein
kinase MASK protein.
Length = 416
Score = 75.8 bits (178), Expect = 1e-12
Identities = 62/199 (31%), Positives = 97/199 (48%), Gaps = 20/199 (10%)
Query: 716 LYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLD 775
L+I ME+ + + G F E F+ + +EI++GL ++H IHRD+K N+ L
Sbjct: 95 LWIIMEYLGGGSALDLLRAGPFDE-FQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLS 153
Query: 776 SNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQ 835
VK+ DFG+A G + + K+ +GT ++APE++Q + Y+
Sbjct: 154 EQGDVKLADFGVA-----GQLTDTQIKRNTF-------VGTPFWMAPEVIQQSA---YDS 198
Query: 836 KVDIYSLGIILFEMFH-PPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLL 894
K DI+SLGI E+ P + M M VL L K+ D ++ K+ I L
Sbjct: 199 KADIWSLGITAIELAKGEPPNSDMHPMRVLF-LIPKNNPPTLVGDFTKSFKEF--IDACL 255
Query: 895 NHEASLRPTCAELLASEHV 913
N + S RPT ELL + +
Sbjct: 256 NKDPSFRPTAKELLKHKFI 274
Score = 42.3 bits (95), Expect = 0.013
Identities = 31/130 (23%), Positives = 66/130 (50%), Gaps = 14/130 (10%)
Query: 289 DFQTRNKQLTSIQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSL 348
D + ++ IQQ++ L++ ++ + Y + + SK ++I ++ G S
Sbjct: 56 DLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYL------KGSK--LWIIMEYLGGGSA 107
Query: 349 KNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLV 408
+L++ +G D F++ +L+ + G L+ LH+ IHRD+++ NV + + G VKL
Sbjct: 108 LDLLR--AGPFDEFQIATMLKEILKG----LDYLHSEKKIHRDIKAANVLLSEQGDVKLA 161
Query: 409 GASLDTRLAE 418
+ +L +
Sbjct: 162 DFGVAGQLTD 171
Score = 37.9 bits (84), Expect = 0.29
Identities = 21/80 (26%), Positives = 43/80 (53%), Gaps = 1/80 (1%)
Query: 527 NGLSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKL 586
N ++ + F L +GKG+FG+V K + AIK + L ++ + I +E+ +
Sbjct: 15 NNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEI-EDIQQEITV 73
Query: 587 LSRLNHENVVRYYNAWIEST 606
LS+ + V +YY ++++ +
Sbjct: 74 LSQCDSSYVTKYYGSYLKGS 93
Score = 33.5 bits (73), Expect = 6.2
Identities = 14/37 (37%), Positives = 23/37 (62%)
Query: 464 KDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTKKPYV 500
K+FI CL +D + +AK+L+ H F+V+ K Y+
Sbjct: 248 KEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYL 284
>U56816-1|AAC50949.1| 499|Homo sapiens kinase Myt1 protein.
Length = 499
Score = 75.4 bits (177), Expect = 2e-12
Identities = 58/196 (29%), Positives = 88/196 (44%), Gaps = 23/196 (11%)
Query: 715 VLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
+LY+Q E C + G + W R+ + LAH+H +G++H D+KP NIFL
Sbjct: 182 ILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFL 241
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
K+GDFGL + T G+ Q G Y+APELLQ + Y
Sbjct: 242 GPRGRCKLGDFGLLVELGT-------------AGAGEVQEGDPRYMAPELLQGS----YG 284
Query: 835 QKVDIYSLGIILFEM-FHPPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWL 893
D++SLG+ + E+ + L G E L + +P +F + + V+ +
Sbjct: 285 TAADVFSLGLTILEVACNMELPHGGEGWQQL-----RQGYLPPEFTAGLSSELRSVLVMM 339
Query: 894 LNHEASLRPTCAELLA 909
L + LR T LLA
Sbjct: 340 LEPDPKLRATAEALLA 355
Score = 39.1 bits (87), Expect = 0.12
Identities = 24/70 (34%), Positives = 36/70 (51%), Gaps = 1/70 (1%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL-NHEN 594
F+ L+ LG G++G+V KV++K DG YA+KR + + EV ++ H
Sbjct: 110 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPC 169
Query: 595 VVRYYNAWIE 604
VR AW E
Sbjct: 170 CVRLEQAWEE 179
>BC130011-1|AAI30012.1| 485|Homo sapiens PKMYT1 protein protein.
Length = 485
Score = 75.4 bits (177), Expect = 2e-12
Identities = 58/196 (29%), Positives = 88/196 (44%), Gaps = 23/196 (11%)
Query: 715 VLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
+LY+Q E C + G + W R+ + LAH+H +G++H D+KP NIFL
Sbjct: 182 ILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFL 241
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
K+GDFGL + T G+ Q G Y+APELLQ + Y
Sbjct: 242 GPRGRCKLGDFGLLVELGT-------------AGAGEVQEGDPRYMAPELLQGS----YG 284
Query: 835 QKVDIYSLGIILFEM-FHPPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWL 893
D++SLG+ + E+ + L G E L + +P +F + + V+ +
Sbjct: 285 TAADVFSLGLTILEVACNMELPHGGEGWQQL-----RQGYLPPEFTAGLSSELRSVLVMM 339
Query: 894 LNHEASLRPTCAELLA 909
L + LR T LLA
Sbjct: 340 LEPDPKLRATAEALLA 355
Score = 39.1 bits (87), Expect = 0.12
Identities = 24/70 (34%), Positives = 36/70 (51%), Gaps = 1/70 (1%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL-NHEN 594
F+ L+ LG G++G+V KV++K DG YA+KR + + EV ++ H
Sbjct: 110 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPC 169
Query: 595 VVRYYNAWIE 604
VR AW E
Sbjct: 170 CVRLEQAWEE 179
>BC121162-1|AAI21163.1| 485|Homo sapiens PKMYT1 protein protein.
Length = 485
Score = 75.4 bits (177), Expect = 2e-12
Identities = 58/196 (29%), Positives = 88/196 (44%), Gaps = 23/196 (11%)
Query: 715 VLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
+LY+Q E C + G + W R+ + LAH+H +G++H D+KP NIFL
Sbjct: 182 ILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFL 241
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
K+GDFGL + T G+ Q G Y+APELLQ + Y
Sbjct: 242 GPRGRCKLGDFGLLVELGT-------------AGAGEVQEGDPRYMAPELLQGS----YG 284
Query: 835 QKVDIYSLGIILFEM-FHPPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWL 893
D++SLG+ + E+ + L G E L + +P +F + + V+ +
Sbjct: 285 TAADVFSLGLTILEVACNMELPHGGEGWQQL-----RQGYLPPEFTAGLSSELRSVLVMM 339
Query: 894 LNHEASLRPTCAELLA 909
L + LR T LLA
Sbjct: 340 LEPDPKLRATAEALLA 355
Score = 39.1 bits (87), Expect = 0.12
Identities = 24/70 (34%), Positives = 36/70 (51%), Gaps = 1/70 (1%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL-NHEN 594
F+ L+ LG G++G+V KV++K DG YA+KR + + EV ++ H
Sbjct: 110 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPC 169
Query: 595 VVRYYNAWIE 604
VR AW E
Sbjct: 170 CVRLEQAWEE 179
>BC121161-1|AAI21162.1| 485|Homo sapiens PKMYT1 protein protein.
Length = 485
Score = 75.4 bits (177), Expect = 2e-12
Identities = 58/196 (29%), Positives = 88/196 (44%), Gaps = 23/196 (11%)
Query: 715 VLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
+LY+Q E C + G + W R+ + LAH+H +G++H D+KP NIFL
Sbjct: 182 ILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFL 241
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
K+GDFGL + T G+ Q G Y+APELLQ + Y
Sbjct: 242 GPRGRCKLGDFGLLVELGT-------------AGAGEVQEGDPRYMAPELLQGS----YG 284
Query: 835 QKVDIYSLGIILFEM-FHPPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWL 893
D++SLG+ + E+ + L G E L + +P +F + + V+ +
Sbjct: 285 TAADVFSLGLTILEVACNMELPHGGEGWQQL-----RQGYLPPEFTAGLSSELRSVLVMM 339
Query: 894 LNHEASLRPTCAELLA 909
L + LR T LLA
Sbjct: 340 LEPDPKLRATAEALLA 355
Score = 39.1 bits (87), Expect = 0.12
Identities = 24/70 (34%), Positives = 36/70 (51%), Gaps = 1/70 (1%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL-NHEN 594
F+ L+ LG G++G+V KV++K DG YA+KR + + EV ++ H
Sbjct: 110 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPC 169
Query: 595 VVRYYNAWIE 604
VR AW E
Sbjct: 170 CVRLEQAWEE 179
>AF549406-1|AAN40703.1| 499|Homo sapiens membrane-associated
tyrosine- and threonine-specific cdc2-inhibitory kinase
protein.
Length = 499
Score = 75.4 bits (177), Expect = 2e-12
Identities = 58/196 (29%), Positives = 88/196 (44%), Gaps = 23/196 (11%)
Query: 715 VLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
+LY+Q E C + G + W R+ + LAH+H +G++H D+KP NIFL
Sbjct: 182 ILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFL 241
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
K+GDFGL + T G+ Q G Y+APELLQ + Y
Sbjct: 242 GPRGRCKLGDFGLLVELGT-------------AGAGEVQEGDPRYMAPELLQGS----YG 284
Query: 835 QKVDIYSLGIILFEM-FHPPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWL 893
D++SLG+ + E+ + L G E L + +P +F + + V+ +
Sbjct: 285 TAADVFSLGLTILEVACNMELPHGGEGWQQL-----RQGYLPPEFTAGLSSELRSVLVMM 339
Query: 894 LNHEASLRPTCAELLA 909
L + LR T LLA
Sbjct: 340 LEPDPKLRATAEALLA 355
Score = 39.1 bits (87), Expect = 0.12
Identities = 24/70 (34%), Positives = 36/70 (51%), Gaps = 1/70 (1%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL-NHEN 594
F+ L+ LG G++G+V KV++K DG YA+KR + + EV ++ H
Sbjct: 110 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPC 169
Query: 595 VVRYYNAWIE 604
VR AW E
Sbjct: 170 CVRLEQAWEE 179
>AF014118-1|AAB71843.1| 499|Homo sapiens membrane-associated kinase
protein.
Length = 499
Score = 75.4 bits (177), Expect = 2e-12
Identities = 58/196 (29%), Positives = 88/196 (44%), Gaps = 23/196 (11%)
Query: 715 VLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
+LY+Q E C + G + W R+ + LAH+H +G++H D+KP NIFL
Sbjct: 182 ILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFL 241
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
K+GDFGL + T G+ Q G Y+APELLQ + Y
Sbjct: 242 GPRGRCKLGDFGLLVELGT-------------AGAGEVQEGDPRYMAPELLQGS----YG 284
Query: 835 QKVDIYSLGIILFEM-FHPPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWL 893
D++SLG+ + E+ + L G E L + +P +F + + V+ +
Sbjct: 285 TAADVFSLGLTILEVACNMELPHGGEGWQQL-----RQGYLPPEFTAGLSSELRSVLVMM 339
Query: 894 LNHEASLRPTCAELLA 909
L + LR T LLA
Sbjct: 340 LEPDPKLRATAEALLA 355
Score = 39.1 bits (87), Expect = 0.12
Identities = 24/70 (34%), Positives = 36/70 (51%), Gaps = 1/70 (1%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL-NHEN 594
F+ L+ LG G++G+V KV++K DG YA+KR + + EV ++ H
Sbjct: 110 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPC 169
Query: 595 VVRYYNAWIE 604
VR AW E
Sbjct: 170 CVRLEQAWEE 179
>AC004235-1|AAC04477.1| 495|Homo sapiens Myt1 protein.
Length = 495
Score = 75.4 bits (177), Expect = 2e-12
Identities = 58/196 (29%), Positives = 88/196 (44%), Gaps = 23/196 (11%)
Query: 715 VLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
+LY+Q E C + G + W R+ + LAH+H +G++H D+KP NIFL
Sbjct: 178 ILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFL 237
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
K+GDFGL + T G+ Q G Y+APELLQ + Y
Sbjct: 238 GPRGRCKLGDFGLLVELGT-------------AGAGEVQEGDPRYMAPELLQGS----YG 280
Query: 835 QKVDIYSLGIILFEM-FHPPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWL 893
D++SLG+ + E+ + L G E L + +P +F + + V+ +
Sbjct: 281 TAADVFSLGLTILEVACNMELPHGGEGWQQL-----RQGYLPPEFTAGLSSELRSVLVMM 335
Query: 894 LNHEASLRPTCAELLA 909
L + LR T LLA
Sbjct: 336 LEPDPKLRATAEALLA 351
Score = 39.1 bits (87), Expect = 0.12
Identities = 24/70 (34%), Positives = 36/70 (51%), Gaps = 1/70 (1%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL-NHEN 594
F+ L+ LG G++G+V KV++K DG YA+KR + + EV ++ H
Sbjct: 106 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPC 165
Query: 595 VVRYYNAWIE 604
VR AW E
Sbjct: 166 CVRLEQAWEE 175
>AC004233-1|AAC04478.1| 499|Homo sapiens Myt1 protein.
Length = 499
Score = 75.4 bits (177), Expect = 2e-12
Identities = 58/196 (29%), Positives = 88/196 (44%), Gaps = 23/196 (11%)
Query: 715 VLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
+LY+Q E C + G + W R+ + LAH+H +G++H D+KP NIFL
Sbjct: 182 ILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFL 241
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
K+GDFGL + T G+ Q G Y+APELLQ + Y
Sbjct: 242 GPRGRCKLGDFGLLVELGT-------------AGAGEVQEGDPRYMAPELLQGS----YG 284
Query: 835 QKVDIYSLGIILFEM-FHPPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWL 893
D++SLG+ + E+ + L G E L + +P +F + + V+ +
Sbjct: 285 TAADVFSLGLTILEVACNMELPHGGEGWQQL-----RQGYLPPEFTAGLSSELRSVLVMM 339
Query: 894 LNHEASLRPTCAELLA 909
L + LR T LLA
Sbjct: 340 LEPDPKLRATAEALLA 355
Score = 39.1 bits (87), Expect = 0.12
Identities = 24/70 (34%), Positives = 36/70 (51%), Gaps = 1/70 (1%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL-NHEN 594
F+ L+ LG G++G+V KV++K DG YA+KR + + EV ++ H
Sbjct: 110 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPC 169
Query: 595 VVRYYNAWIE 604
VR AW E
Sbjct: 170 CVRLEQAWEE 179
>AB209179-1|BAD92416.1| 546|Homo sapiens polo-like kinase variant
protein.
Length = 546
Score = 75.4 bits (177), Expect = 2e-12
Identities = 58/168 (34%), Positives = 91/168 (54%), Gaps = 26/168 (15%)
Query: 748 REIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIG 807
R+IV G ++H+ +IHRDLK N+FL+ + VKIGDFGLATK E G
Sbjct: 101 RQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKV------------EYDG 148
Query: 808 GSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMF--HPPLETGMERMMVLT 865
GT Y+APE+L +K ++ +VD++S+G I++ + PP ET + T
Sbjct: 149 ERKKTLCGTPNYIAPEVL---SKKGHSFEVDVWSIGCIMYTLLVGKPPFETS---CLKET 202
Query: 866 NLRSKDIVIPNKFDVDENVKQI--HVIRWLLNHEASLRPTCAELLASE 911
LR K N++ + +++ + +I+ +L + + RPT ELL E
Sbjct: 203 YLRIK----KNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDE 246
>BC026060-1|AAH26060.1| 541|Homo sapiens
calcium/calmodulin-dependent protein kinase kinase 2,
beta protein.
Length = 541
Score = 74.9 bits (176), Expect = 2e-12
Identities = 38/142 (26%), Positives = 81/142 (57%), Gaps = 13/142 (9%)
Query: 747 FREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEI 806
F+++++G+ ++H + +IHRD+KP N+ + + H+KI DFG++ + F G
Sbjct: 293 FQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE-FKG-----------S 340
Query: 807 GGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVL-T 865
L+ +GT ++APE L K+ + +D++++G+ L+ ER+M L +
Sbjct: 341 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHS 400
Query: 866 NLRSKDIVIPNKFDVDENVKQI 887
++S+ + P++ D+ E++K +
Sbjct: 401 KIKSQALEFPDQPDIAEDLKDL 422
>BC000318-1|AAH00318.2| 266|Homo sapiens CAMKK2 protein protein.
Length = 266
Score = 74.9 bits (176), Expect = 2e-12
Identities = 38/142 (26%), Positives = 81/142 (57%), Gaps = 13/142 (9%)
Query: 747 FREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEI 806
F+++++G+ ++H + +IHRD+KP N+ + + H+KI DFG++ + F G
Sbjct: 61 FQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE-FKG-----------S 108
Query: 807 GGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVL-T 865
L+ +GT ++APE L K+ + +D++++G+ L+ ER+M L +
Sbjct: 109 DALLSNTVGTPAFMAPESLSETCKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHS 168
Query: 866 NLRSKDIVIPNKFDVDENVKQI 887
++S+ + P++ D+ E++K +
Sbjct: 169 KIKSQALEFPDQPDIAEDLKDL 190
>AY995220-1|AAX99363.1| 509|Homo sapiens histidyl-tRNA synthetase
protein.
Length = 509
Score = 74.9 bits (176), Expect = 2e-12
Identities = 78/357 (21%), Positives = 159/357 (44%), Gaps = 29/357 (8%)
Query: 971 EFVKDAVVKVFKSHGALEFAPPLLIPRARAWDQYPNAVKVM----TSSGSVCHLPHDLRL 1026
E V D +++ FK HGA P+ + +Y K++ G + L +DL +
Sbjct: 74 EKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTV 133
Query: 1027 PFARHIAYSGIKNLRRFIVDRVYREKH---VQGFHPKEILECAYDIVTPKTDSLWPDAEL 1083
PFAR++A + + N++R+ + +VYR + +G + +E +C +DI D + PDAE
Sbjct: 134 PFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRY-REFYQCDFDI-AGNFDPMIPDAEC 191
Query: 1084 IEVASRAASECSL-KVSIQLNHTELIRVLLQSCGVPTDKQADI---YPVLVDVSFGRIXX 1139
+++ S + +++N ++ + CGV K I L VS+ +
Sbjct: 192 LKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKN 251
Query: 1140 XXXXXXXXXXCITNRDVTNLVRLMEADAPVQELRELVTPLVKQAKCSRIASQAVHDLEAV 1199
+ +R + + V+ + ++L L P + Q ++ A + + DL+ +
Sbjct: 252 EMVGEKGLAPEVADR-IGDYVQQHGGVSLAEQL--LQDPKLSQ---NKQALEGLGDLKLL 305
Query: 1200 YRNAKALGCECPMTVAPLSAYNVTQHSGVFWQMSVVRSEQKSITKRRSGDLIAAGGRYDA 1259
+ G + ++ A + ++GV ++ ++++ ++ + +AAGGRYD
Sbjct: 306 FEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDG 365
Query: 1260 LVKEFWNVASAENDQDSADLNVCSVGFSMSLERMAAFLNKLETQTNVPIKSNETPLV 1316
LV F D V VG S+ +ER+ + + + I++ ET ++
Sbjct: 366 LVGMF----------DPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVL 412
>AL834322-1|CAD38990.1| 365|Homo sapiens hypothetical protein
protein.
Length = 365
Score = 74.9 bits (176), Expect = 2e-12
Identities = 38/142 (26%), Positives = 81/142 (57%), Gaps = 13/142 (9%)
Query: 747 FREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEI 806
F+++++G+ ++H + +IHRD+KP N+ + + H+KI DFG++ + F G
Sbjct: 102 FQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE-FKG-----------S 149
Query: 807 GGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVL-T 865
L+ +GT ++APE L K+ + +D++++G+ L+ ER+M L +
Sbjct: 150 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHS 209
Query: 866 NLRSKDIVIPNKFDVDENVKQI 887
++S+ + P++ D+ E++K +
Sbjct: 210 KIKSQALEFPDQPDIAEDLKDL 231
>AF321402-1|AAK91829.1| 588|Homo sapiens Ca2+/calmodulin-dependent
protein kinase kinase beta 1 protein.
Length = 588
Score = 74.9 bits (176), Expect = 2e-12
Identities = 38/142 (26%), Positives = 81/142 (57%), Gaps = 13/142 (9%)
Query: 747 FREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEI 806
F+++++G+ ++H + +IHRD+KP N+ + + H+KI DFG++ + F G
Sbjct: 293 FQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE-FKG-----------S 340
Query: 807 GGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVL-T 865
L+ +GT ++APE L K+ + +D++++G+ L+ ER+M L +
Sbjct: 341 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHS 400
Query: 866 NLRSKDIVIPNKFDVDENVKQI 887
++S+ + P++ D+ E++K +
Sbjct: 401 KIKSQALEFPDQPDIAEDLKDL 422
>AF321401-1|AAK91830.1| 533|Homo sapiens Ca2+/calmodulin-dependent
protein kinase kinase beta 2 protein.
Length = 533
Score = 74.9 bits (176), Expect = 2e-12
Identities = 38/142 (26%), Positives = 81/142 (57%), Gaps = 13/142 (9%)
Query: 747 FREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEI 806
F+++++G+ ++H + +IHRD+KP N+ + + H+KI DFG++ + F G
Sbjct: 293 FQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE-FKG-----------S 340
Query: 807 GGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVL-T 865
L+ +GT ++APE L K+ + +D++++G+ L+ ER+M L +
Sbjct: 341 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHS 400
Query: 866 NLRSKDIVIPNKFDVDENVKQI 887
++S+ + P++ D+ E++K +
Sbjct: 401 KIKSQALEFPDQPDIAEDLKDL 422
>AF321388-1|AAL37218.1| 498|Homo sapiens CaMKK beta 1 isoform
protein.
Length = 498
Score = 74.9 bits (176), Expect = 2e-12
Identities = 38/142 (26%), Positives = 81/142 (57%), Gaps = 13/142 (9%)
Query: 747 FREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEI 806
F+++++G+ ++H + +IHRD+KP N+ + + H+KI DFG++ + F G
Sbjct: 293 FQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE-FKG-----------S 340
Query: 807 GGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVL-T 865
L+ +GT ++APE L K+ + +D++++G+ L+ ER+M L +
Sbjct: 341 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHS 400
Query: 866 NLRSKDIVIPNKFDVDENVKQI 887
++S+ + P++ D+ E++K +
Sbjct: 401 KIKSQALEFPDQPDIAEDLKDL 422
>AF321387-1|AAL37217.1| 541|Homo sapiens CaMKK beta 1 isoform
protein.
Length = 541
Score = 74.9 bits (176), Expect = 2e-12
Identities = 38/142 (26%), Positives = 81/142 (57%), Gaps = 13/142 (9%)
Query: 747 FREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEI 806
F+++++G+ ++H + +IHRD+KP N+ + + H+KI DFG++ + F G
Sbjct: 293 FQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE-FKG-----------S 340
Query: 807 GGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVL-T 865
L+ +GT ++APE L K+ + +D++++G+ L+ ER+M L +
Sbjct: 341 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHS 400
Query: 866 NLRSKDIVIPNKFDVDENVKQI 887
++S+ + P++ D+ E++K +
Sbjct: 401 KIKSQALEFPDQPDIAEDLKDL 422
>AF321386-1|AAL37216.1| 545|Homo sapiens CaMKK beta 1 isoform
protein.
Length = 545
Score = 74.9 bits (176), Expect = 2e-12
Identities = 38/142 (26%), Positives = 81/142 (57%), Gaps = 13/142 (9%)
Query: 747 FREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEI 806
F+++++G+ ++H + +IHRD+KP N+ + + H+KI DFG++ + F G
Sbjct: 293 FQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE-FKG-----------S 340
Query: 807 GGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVL-T 865
L+ +GT ++APE L K+ + +D++++G+ L+ ER+M L +
Sbjct: 341 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHS 400
Query: 866 NLRSKDIVIPNKFDVDENVKQI 887
++S+ + P++ D+ E++K +
Sbjct: 401 KIKSQALEFPDQPDIAEDLKDL 422
>AF321385-1|AAL37215.1| 490|Homo sapiens CaMKK beta 2 isoform
protein.
Length = 490
Score = 74.9 bits (176), Expect = 2e-12
Identities = 38/142 (26%), Positives = 81/142 (57%), Gaps = 13/142 (9%)
Query: 747 FREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEI 806
F+++++G+ ++H + +IHRD+KP N+ + + H+KI DFG++ + F G
Sbjct: 293 FQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE-FKG-----------S 340
Query: 807 GGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVL-T 865
L+ +GT ++APE L K+ + +D++++G+ L+ ER+M L +
Sbjct: 341 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHS 400
Query: 866 NLRSKDIVIPNKFDVDENVKQI 887
++S+ + P++ D+ E++K +
Sbjct: 401 KIKSQALEFPDQPDIAEDLKDL 422
>AF287631-1|AAK64601.1| 533|Homo sapiens
calcium/calmodulin-dependent protein kinase kinase b2
protein.
Length = 533
Score = 74.9 bits (176), Expect = 2e-12
Identities = 38/142 (26%), Positives = 81/142 (57%), Gaps = 13/142 (9%)
Query: 747 FREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEI 806
F+++++G+ ++H + +IHRD+KP N+ + + H+KI DFG++ + F G
Sbjct: 293 FQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE-FKG-----------S 340
Query: 807 GGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVL-T 865
L+ +GT ++APE L K+ + +D++++G+ L+ ER+M L +
Sbjct: 341 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHS 400
Query: 866 NLRSKDIVIPNKFDVDENVKQI 887
++S+ + P++ D+ E++K +
Sbjct: 401 KIKSQALEFPDQPDIAEDLKDL 422
>AF287630-1|AAK64600.1| 588|Homo sapiens
calcium/calmodulin-dependent protein kinase kinase b1
protein.
Length = 588
Score = 74.9 bits (176), Expect = 2e-12
Identities = 38/142 (26%), Positives = 81/142 (57%), Gaps = 13/142 (9%)
Query: 747 FREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEI 806
F+++++G+ ++H + +IHRD+KP N+ + + H+KI DFG++ + F G
Sbjct: 293 FQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE-FKG-----------S 340
Query: 807 GGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVL-T 865
L+ +GT ++APE L K+ + +D++++G+ L+ ER+M L +
Sbjct: 341 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHS 400
Query: 866 NLRSKDIVIPNKFDVDENVKQI 887
++S+ + P++ D+ E++K +
Sbjct: 401 KIKSQALEFPDQPDIAEDLKDL 422
>AF101264-1|AAD04566.1| 417|Homo sapiens Ca2+/calmodulin-dependent
kinase kinase protein.
Length = 417
Score = 74.9 bits (176), Expect = 2e-12
Identities = 38/142 (26%), Positives = 81/142 (57%), Gaps = 13/142 (9%)
Query: 747 FREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEI 806
F+++++G+ ++H + +IHRD+KP N+ + + H+KI DFG++ + F G
Sbjct: 177 FQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE-FKG-----------S 224
Query: 807 GGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVL-T 865
L+ +GT ++APE L K+ + +D++++G+ L+ ER+M L +
Sbjct: 225 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHS 284
Query: 866 NLRSKDIVIPNKFDVDENVKQI 887
++S+ + P++ D+ E++K +
Sbjct: 285 KIKSQALEFPDQPDIAEDLKDL 306
>AB081337-1|BAC19841.1| 498|Homo sapiens Ca2+/calmodulin-dependent
protein kinase kinase beta-3x protein.
Length = 498
Score = 74.9 bits (176), Expect = 2e-12
Identities = 38/142 (26%), Positives = 81/142 (57%), Gaps = 13/142 (9%)
Query: 747 FREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEI 806
F+++++G+ ++H + +IHRD+KP N+ + + H+KI DFG++ + F G
Sbjct: 293 FQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE-FKG-----------S 340
Query: 807 GGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVL-T 865
L+ +GT ++APE L K+ + +D++++G+ L+ ER+M L +
Sbjct: 341 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHS 400
Query: 866 NLRSKDIVIPNKFDVDENVKQI 887
++S+ + P++ D+ E++K +
Sbjct: 401 KIKSQALEFPDQPDIAEDLKDL 422
>AB081336-1|BAC19840.1| 541|Homo sapiens Ca2+/calmodulin-dependent
protein kinase kinase beta-3 protein.
Length = 541
Score = 74.9 bits (176), Expect = 2e-12
Identities = 38/142 (26%), Positives = 81/142 (57%), Gaps = 13/142 (9%)
Query: 747 FREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEI 806
F+++++G+ ++H + +IHRD+KP N+ + + H+KI DFG++ + F G
Sbjct: 293 FQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE-FKG-----------S 340
Query: 807 GGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVL-T 865
L+ +GT ++APE L K+ + +D++++G+ L+ ER+M L +
Sbjct: 341 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHS 400
Query: 866 NLRSKDIVIPNKFDVDENVKQI 887
++S+ + P++ D+ E++K +
Sbjct: 401 KIKSQALEFPDQPDIAEDLKDL 422
>AB018330-1|BAA34507.2| 557|Homo sapiens KIAA0787 protein protein.
Length = 557
Score = 74.9 bits (176), Expect = 2e-12
Identities = 38/142 (26%), Positives = 81/142 (57%), Gaps = 13/142 (9%)
Query: 747 FREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEI 806
F+++++G+ ++H + +IHRD+KP N+ + + H+KI DFG++ + F G
Sbjct: 294 FQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE-FKG-----------S 341
Query: 807 GGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVL-T 865
L+ +GT ++APE L K+ + +D++++G+ L+ ER+M L +
Sbjct: 342 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHS 401
Query: 866 NLRSKDIVIPNKFDVDENVKQI 887
++S+ + P++ D+ E++K +
Sbjct: 402 KIKSQALEFPDQPDIAEDLKDL 423
>BT019619-1|AAV38425.1| 431|Homo sapiens serine/threonine kinase 24
(STE20 homolog, yeast) protein.
Length = 431
Score = 74.5 bits (175), Expect = 3e-12
Identities = 67/243 (27%), Positives = 113/243 (46%), Gaps = 26/243 (10%)
Query: 680 ELIEFEKTSDDEES--QTLPSEDVVDAP---RPQSERLKQV-LYIQMEFCEKHTLRQAID 733
++I+ E+ D+ E Q + D+P + LK L+I ME+ + ++
Sbjct: 53 KIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE 112
Query: 734 NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFT 793
G E A + REI++GL ++H IHRD+K N+ L + VK+ DFG+A
Sbjct: 113 PGPLDETQIA-TILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVA----- 166
Query: 794 GLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH-P 852
G + + K+ +GT ++APE+++ + Y+ K DI+SLGI E+
Sbjct: 167 GQLTDTQIKRNTF-------VGTPFWMAPEVIKQSA---YDSKADIWSLGITAIELARGE 216
Query: 853 PLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEH 912
P + + M VL + + P + + + + LN E S RPT ELL +
Sbjct: 217 PPHSELHPMKVLFLIPKNN---PPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKF 273
Query: 913 VPR 915
+ R
Sbjct: 274 ILR 276
Score = 40.7 bits (91), Expect = 0.041
Identities = 53/243 (21%), Positives = 105/243 (43%), Gaps = 45/243 (18%)
Query: 289 DFQTRNKQLTSIQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSL 348
D + ++ IQQ++ L++ + PYV K ++I ++ G S
Sbjct: 56 DLEEAEDEIEDIQQEITVLSQCDS----PYVT----KYYGSYLKDTKLWIIMEYLGGGSA 107
Query: 349 KNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLV 408
+L++ G D ++ +LR + G L+ LH+ IHRD+++ NV + + G+VKL
Sbjct: 108 LDLLEP--GPLDETQIATILREILKG----LDYLHSEKKIHRDIKAANVLLSEHGEVKLA 161
Query: 409 GASLDTRLAE-MLDNDNYCD----------KQT---PAQDIYATGQLLLSIVCKEKSYTE 454
+ +L + + + + KQ+ DI++ G + + E ++E
Sbjct: 162 DFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSE 221
Query: 455 ---------IPQELPCV--------AKDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTKK 497
IP+ P K+F+ CL ++ + +AK+L+ H F++ K
Sbjct: 222 LHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKT 281
Query: 498 PYV 500
Y+
Sbjct: 282 SYL 284
Score = 38.3 bits (85), Expect = 0.22
Identities = 21/71 (29%), Positives = 39/71 (54%), Gaps = 1/71 (1%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENV 595
F L +GKG+FG+V K + AIK + L ++ + I +E+ +LS+ + V
Sbjct: 24 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEI-EDIQQEITVLSQCDSPYV 82
Query: 596 VRYYNAWIEST 606
+YY ++++ T
Sbjct: 83 TKYYGSYLKDT 93
>BC071579-1|AAH71579.1| 873|Homo sapiens MAP4K3 protein protein.
Length = 873
Score = 74.5 bits (175), Expect = 3e-12
Identities = 59/211 (27%), Positives = 102/211 (48%), Gaps = 24/211 (11%)
Query: 716 LYIQMEFCEKHTLRQAID-NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
L+I MEFC +L+ G E A+ + RE ++GL ++H +G +HRD+K NI L
Sbjct: 86 LWICMEFCGGGSLQDIYHVTGPLSELQIAY-VSRETLQGLYYLHSKGKMHRDIKGANILL 144
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
N HVK+ DFG++ + + K++ IGT ++APE+ K YN
Sbjct: 145 TDNGHVKLADFGVSAQITATI-----AKRKSF-------IGTPYWMAPEVAAVERKGGYN 192
Query: 835 QKVDIYSLGIILFEM--FHPPLET--GMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVI 890
Q D++++GI E+ PP+ M + ++T + + +K + H +
Sbjct: 193 QLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFH--HFV 250
Query: 891 RWLLNHEASLRPTCAELL----ASEHVPRAV 917
+ L RPT +LL ++H+ R++
Sbjct: 251 KMALTKNPKKRPTAEKLLQHPFVTQHLTRSL 281
Score = 44.0 bits (99), Expect = 0.004
Identities = 21/70 (30%), Positives = 40/70 (57%), Gaps = 4/70 (5%)
Query: 535 EFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNP-ESVQLNKKITREVKLLSRLNHE 593
+FE++ +G G +GDV K +N G AIK ++L P E + + +E+ ++ H
Sbjct: 15 DFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV---VQQEIIMMKDCKHP 71
Query: 594 NVVRYYNAWI 603
N+V Y+ +++
Sbjct: 72 NIVAYFGSYL 81
Score = 38.7 bits (86), Expect = 0.16
Identities = 36/158 (22%), Positives = 66/158 (41%), Gaps = 20/158 (12%)
Query: 259 SSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSNASLIPY 318
S T Y A + +TGE K + P DF +QQ++ + + +++ Y
Sbjct: 24 SGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV-------VQQEIIMMKDCKHPNIVAY 76
Query: 319 VAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSA 378
+ R K ++I F G SL+++ S+ + +V+ L
Sbjct: 77 FGSYL------RRDK--LWICMEFCGGGSLQDIYHVTGPLSEL-----QIAYVSRETLQG 123
Query: 379 LNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRL 416
L LH+ +HRD++ N+ + D G VKL + ++
Sbjct: 124 LYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQI 161
>BC065378-1|AAH65378.1| 431|Homo sapiens serine/threonine kinase 24
(STE20 homolog, yeast) protein.
Length = 431
Score = 74.5 bits (175), Expect = 3e-12
Identities = 67/243 (27%), Positives = 113/243 (46%), Gaps = 26/243 (10%)
Query: 680 ELIEFEKTSDDEES--QTLPSEDVVDAP---RPQSERLKQV-LYIQMEFCEKHTLRQAID 733
++I+ E+ D+ E Q + D+P + LK L+I ME+ + ++
Sbjct: 53 KIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE 112
Query: 734 NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFT 793
G E A + REI++GL ++H IHRD+K N+ L + VK+ DFG+A
Sbjct: 113 PGPLDETQIA-TILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVA----- 166
Query: 794 GLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH-P 852
G + + K+ +GT ++APE+++ + Y+ K DI+SLGI E+
Sbjct: 167 GQLTDTQIKRNTF-------VGTPFWMAPEVIKQSA---YDSKADIWSLGITAIELARGE 216
Query: 853 PLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEH 912
P + + M VL + + P + + + + LN E S RPT ELL +
Sbjct: 217 PPHSELHPMKVLFLIPKNN---PPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKF 273
Query: 913 VPR 915
+ R
Sbjct: 274 ILR 276
Score = 40.7 bits (91), Expect = 0.041
Identities = 53/243 (21%), Positives = 105/243 (43%), Gaps = 45/243 (18%)
Query: 289 DFQTRNKQLTSIQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSL 348
D + ++ IQQ++ L++ + PYV K ++I ++ G S
Sbjct: 56 DLEEAEDEIEDIQQEITVLSQCDS----PYVT----KYYGSYLKDTKLWIIMEYLGGGSA 107
Query: 349 KNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLV 408
+L++ G D ++ +LR + G L+ LH+ IHRD+++ NV + + G+VKL
Sbjct: 108 LDLLEP--GPLDETQIATILREILKG----LDYLHSEKKIHRDIKAANVLLSEHGEVKLA 161
Query: 409 GASLDTRLAE-MLDNDNYCD----------KQT---PAQDIYATGQLLLSIVCKEKSYTE 454
+ +L + + + + KQ+ DI++ G + + E ++E
Sbjct: 162 DFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSE 221
Query: 455 ---------IPQELPCV--------AKDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTKK 497
IP+ P K+F+ CL ++ + +AK+L+ H F++ K
Sbjct: 222 LHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKT 281
Query: 498 PYV 500
Y+
Sbjct: 282 SYL 284
Score = 38.3 bits (85), Expect = 0.22
Identities = 21/71 (29%), Positives = 39/71 (54%), Gaps = 1/71 (1%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENV 595
F L +GKG+FG+V K + AIK + L ++ + I +E+ +LS+ + V
Sbjct: 24 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEI-EDIQQEITVLSQCDSPYV 82
Query: 596 VRYYNAWIEST 606
+YY ++++ T
Sbjct: 83 TKYYGSYLKDT 93
>BC063885-1|AAH63885.1| 708|Homo sapiens NIMA (never in mitosis
gene a)-related kinase 5 protein.
Length = 708
Score = 74.5 bits (175), Expect = 3e-12
Identities = 52/139 (37%), Positives = 75/139 (53%), Gaps = 22/139 (15%)
Query: 716 LYIQMEFCEKHTLRQAIDNG---LFQE-HFRAWRLFREIVEGLAHVHQRGMIHRDLKPVN 771
L+I ME+C+ L + I+ LF E W F +I GL H+H R ++HRD+K N
Sbjct: 76 LFIVMEYCDGGDLMKRINRQRGVLFSEDQILGW--FVQISLGLKHIHDRKILHRDIKAQN 133
Query: 772 IFLDSNDHV-KIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATK 830
IFL N V K+GDFG+A + E+ + IGT Y++PE+ Q+
Sbjct: 134 IFLSKNGMVAKLGDFGIARVLNNSM---------ELARTC---IGTPYYLSPEICQNKP- 180
Query: 831 VIYNQKVDIYSLGIILFEM 849
YN K DI+SLG +L+E+
Sbjct: 181 --YNNKTDIWSLGCVLYEL 197
Score = 48.4 bits (110), Expect = 2e-04
Identities = 21/71 (29%), Positives = 39/71 (54%)
Query: 535 EFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHEN 594
+++V+ +G+GAFG K K D IK + +Q + +EV LL ++ H N
Sbjct: 3 KYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHPN 62
Query: 595 VVRYYNAWIES 605
+V ++N++ E+
Sbjct: 63 IVAFFNSFQEN 73
Score = 35.9 bits (79), Expect = 1.2
Identities = 30/119 (25%), Positives = 55/119 (46%), Gaps = 15/119 (12%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSG--FSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVR 393
++I + G L + + G FS+ ++LG ++ G L +H I+HRD++
Sbjct: 76 LFIVMEYCDGGDLMKRINRQRGVLFSED-QILGWFVQISLG----LKHIHDRKILHRDIK 130
Query: 394 SENVFVDDVGQVKLVGASLDTRLAEMLDNDNYCDKQTPAQDIYATGQLLLSIVCKEKSY 452
++N+F+ G V +G D +A +L+N A+ T L +C+ K Y
Sbjct: 131 AQNIFLSKNGMVAKLG---DFGIARVLNN-----SMELARTCIGTPYYLSPEICQNKPY 181
>BC035578-1|AAH35578.1| 431|Homo sapiens serine/threonine kinase 24
(STE20 homolog, yeast) protein.
Length = 431
Score = 74.5 bits (175), Expect = 3e-12
Identities = 67/243 (27%), Positives = 113/243 (46%), Gaps = 26/243 (10%)
Query: 680 ELIEFEKTSDDEES--QTLPSEDVVDAP---RPQSERLKQV-LYIQMEFCEKHTLRQAID 733
++I+ E+ D+ E Q + D+P + LK L+I ME+ + ++
Sbjct: 53 KIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE 112
Query: 734 NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFT 793
G E A + REI++GL ++H IHRD+K N+ L + VK+ DFG+A
Sbjct: 113 PGPLDETQIA-TILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVA----- 166
Query: 794 GLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH-P 852
G + + K+ +GT ++APE+++ + Y+ K DI+SLGI E+
Sbjct: 167 GQLTDTQIKRNTF-------VGTPFWMAPEVIKQSA---YDSKADIWSLGITAIELARGE 216
Query: 853 PLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEH 912
P + + M VL + + P + + + + LN E S RPT ELL +
Sbjct: 217 PPHSELHPMKVLFLIPKNN---PPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKF 273
Query: 913 VPR 915
+ R
Sbjct: 274 ILR 276
Score = 40.7 bits (91), Expect = 0.041
Identities = 53/243 (21%), Positives = 105/243 (43%), Gaps = 45/243 (18%)
Query: 289 DFQTRNKQLTSIQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSL 348
D + ++ IQQ++ L++ + PYV K ++I ++ G S
Sbjct: 56 DLEEAEDEIEDIQQEITVLSQCDS----PYVT----KYYGSYLKDTKLWIIMEYLGGGSA 107
Query: 349 KNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLV 408
+L++ G D ++ +LR + G L+ LH+ IHRD+++ NV + + G+VKL
Sbjct: 108 LDLLEP--GPLDETQIATILREILKG----LDYLHSEKKIHRDIKAANVLLSEHGEVKLA 161
Query: 409 GASLDTRLAE-MLDNDNYCD----------KQT---PAQDIYATGQLLLSIVCKEKSYTE 454
+ +L + + + + KQ+ DI++ G + + E ++E
Sbjct: 162 DFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSE 221
Query: 455 ---------IPQELPCV--------AKDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTKK 497
IP+ P K+F+ CL ++ + +AK+L+ H F++ K
Sbjct: 222 LHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKT 281
Query: 498 PYV 500
Y+
Sbjct: 282 SYL 284
Score = 38.3 bits (85), Expect = 0.22
Identities = 21/71 (29%), Positives = 39/71 (54%), Gaps = 1/71 (1%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENV 595
F L +GKG+FG+V K + AIK + L ++ + I +E+ +LS+ + V
Sbjct: 24 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEI-EDIQQEITVLSQCDSPYV 82
Query: 596 VRYYNAWIEST 606
+YY ++++ T
Sbjct: 83 TKYYGSYLKDT 93
>BC031231-1|AAH31231.1| 514|Homo sapiens serine/threonine kinase 33
protein.
Length = 514
Score = 74.5 bits (175), Expect = 3e-12
Identities = 59/211 (27%), Positives = 108/211 (51%), Gaps = 34/211 (16%)
Query: 716 LYIQMEFCEKHTLRQAIDN-GLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
+Y+ ME CE L++ +D G F E+ W + + + +A++H ++HRDLK NI +
Sbjct: 188 MYLVMELCEDGELKEILDRKGHFSENETRW-IIQSLASAIAYLHNNDIVHRDLKLENIMV 246
Query: 775 ------DSND---HVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELL 825
D+N+ ++K+ DFGLA K KQ L GT +Y+APE++
Sbjct: 247 KSSLIDDNNEINLNIKVTDFGLAVK-----------KQSRSEAMLQATCGTPIYMAPEVI 295
Query: 826 QSATKVIYNQKVDIYSLGIILFEMF--HPP-LETGMERMMVLTNLRSKDIVIPNKF--DV 880
+ Y+Q+ DI+S+G++++ + PP L + E++ L +R ++ N +
Sbjct: 296 SAHD---YSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFEL--IRKGELHFENAVWNSI 350
Query: 881 DENVKQIHVIRWLLNHEASLRPTCAELLASE 911
+ K V++ L+ + + R T ELL ++
Sbjct: 351 SDCAKS--VLKQLMKVDPAHRITAKELLDNQ 379
Score = 39.5 bits (88), Expect = 0.094
Identities = 25/105 (23%), Positives = 47/105 (44%), Gaps = 2/105 (1%)
Query: 492 EAPTKKPYVKRAXXXXXXXXXXXAVKKIRHMSFANNGLSRLDAEFEVLAWLGKGAFGDVL 551
+ P++ V+R K+ H+ N + ++ + LGKG+FG V+
Sbjct: 74 DLPSRTSNVERKASQQQWGRGNFTEGKVPHIRIENG--AAIEEIYTFGRILGKGSFGIVI 131
Query: 552 KVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENVV 596
+ +K +AIK+V K + REV +L + HE+++
Sbjct: 132 EATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHII 176
Score = 33.1 bits (72), Expect = 8.1
Identities = 35/153 (22%), Positives = 67/153 (43%), Gaps = 20/153 (13%)
Query: 248 KKVY-IGSCLGHSSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKS 306
+++Y G LG S G A D +T KW+I + + + + ++++V
Sbjct: 113 EEIYTFGRILGKGSFGIVIE-ATDKET-----ETKWAIKKVNKEKAGSSAVKLLEREVNI 166
Query: 307 LARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLG 366
L + + +I +E E K+ +Y+ LK ++ + FS+
Sbjct: 167 LKSVKHEHIIH---LEQVFETPKK-----MYLVMELCEDGELKEILDRKGHFSE-----N 213
Query: 367 LLRHVADGVLSALNELHAANIIHRDVRSENVFV 399
R + + SA+ LH +I+HRD++ EN+ V
Sbjct: 214 ETRWIIQSLASAIAYLHNNDIVHRDLKLENIMV 246
>AL356423-3|CAI13115.1| 431|Homo sapiens serine/threonine kinase 24
(STE20 homolog, yeast) protein.
Length = 431
Score = 74.5 bits (175), Expect = 3e-12
Identities = 67/243 (27%), Positives = 113/243 (46%), Gaps = 26/243 (10%)
Query: 680 ELIEFEKTSDDEES--QTLPSEDVVDAP---RPQSERLKQV-LYIQMEFCEKHTLRQAID 733
++I+ E+ D+ E Q + D+P + LK L+I ME+ + ++
Sbjct: 53 KIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE 112
Query: 734 NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFT 793
G E A + REI++GL ++H IHRD+K N+ L + VK+ DFG+A
Sbjct: 113 PGPLDETQIA-TILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVA----- 166
Query: 794 GLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH-P 852
G + + K+ +GT ++APE+++ + Y+ K DI+SLGI E+
Sbjct: 167 GQLTDTQIKRNTF-------VGTPFWMAPEVIKQSA---YDSKADIWSLGITAIELARGE 216
Query: 853 PLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEH 912
P + + M VL + + P + + + + LN E S RPT ELL +
Sbjct: 217 PPHSELHPMKVLFLIPKNN---PPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKF 273
Query: 913 VPR 915
+ R
Sbjct: 274 ILR 276
Score = 40.7 bits (91), Expect = 0.041
Identities = 53/243 (21%), Positives = 105/243 (43%), Gaps = 45/243 (18%)
Query: 289 DFQTRNKQLTSIQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSL 348
D + ++ IQQ++ L++ + PYV K ++I ++ G S
Sbjct: 56 DLEEAEDEIEDIQQEITVLSQCDS----PYVT----KYYGSYLKDTKLWIIMEYLGGGSA 107
Query: 349 KNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLV 408
+L++ G D ++ +LR + G L+ LH+ IHRD+++ NV + + G+VKL
Sbjct: 108 LDLLEP--GPLDETQIATILREILKG----LDYLHSEKKIHRDIKAANVLLSEHGEVKLA 161
Query: 409 GASLDTRLAE-MLDNDNYCD----------KQT---PAQDIYATGQLLLSIVCKEKSYTE 454
+ +L + + + + KQ+ DI++ G + + E ++E
Sbjct: 162 DFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSE 221
Query: 455 ---------IPQELPCV--------AKDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTKK 497
IP+ P K+F+ CL ++ + +AK+L+ H F++ K
Sbjct: 222 LHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKT 281
Query: 498 PYV 500
Y+
Sbjct: 282 SYL 284
Score = 38.3 bits (85), Expect = 0.22
Identities = 21/71 (29%), Positives = 39/71 (54%), Gaps = 1/71 (1%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENV 595
F L +GKG+FG+V K + AIK + L ++ + I +E+ +LS+ + V
Sbjct: 24 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEI-EDIQQEITVLSQCDSPYV 82
Query: 596 VRYYNAWIEST 606
+YY ++++ T
Sbjct: 83 TKYYGSYLKDT 93
>AL356423-2|CAI13114.1| 443|Homo sapiens serine/threonine kinase 24
(STE20 homolog, yeast) protein.
Length = 443
Score = 74.5 bits (175), Expect = 3e-12
Identities = 67/243 (27%), Positives = 113/243 (46%), Gaps = 26/243 (10%)
Query: 680 ELIEFEKTSDDEES--QTLPSEDVVDAP---RPQSERLKQV-LYIQMEFCEKHTLRQAID 733
++I+ E+ D+ E Q + D+P + LK L+I ME+ + ++
Sbjct: 65 KIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE 124
Query: 734 NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFT 793
G E A + REI++GL ++H IHRD+K N+ L + VK+ DFG+A
Sbjct: 125 PGPLDETQIA-TILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVA----- 178
Query: 794 GLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH-P 852
G + + K+ +GT ++APE+++ + Y+ K DI+SLGI E+
Sbjct: 179 GQLTDTQIKRNTF-------VGTPFWMAPEVIKQSA---YDSKADIWSLGITAIELARGE 228
Query: 853 PLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEH 912
P + + M VL + + P + + + + LN E S RPT ELL +
Sbjct: 229 PPHSELHPMKVLFLIPKNN---PPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKF 285
Query: 913 VPR 915
+ R
Sbjct: 286 ILR 288
Score = 40.7 bits (91), Expect = 0.041
Identities = 53/243 (21%), Positives = 105/243 (43%), Gaps = 45/243 (18%)
Query: 289 DFQTRNKQLTSIQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSL 348
D + ++ IQQ++ L++ + PYV K ++I ++ G S
Sbjct: 68 DLEEAEDEIEDIQQEITVLSQCDS----PYVT----KYYGSYLKDTKLWIIMEYLGGGSA 119
Query: 349 KNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLV 408
+L++ G D ++ +LR + G L+ LH+ IHRD+++ NV + + G+VKL
Sbjct: 120 LDLLEP--GPLDETQIATILREILKG----LDYLHSEKKIHRDIKAANVLLSEHGEVKLA 173
Query: 409 GASLDTRLAE-MLDNDNYCD----------KQT---PAQDIYATGQLLLSIVCKEKSYTE 454
+ +L + + + + KQ+ DI++ G + + E ++E
Sbjct: 174 DFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSE 233
Query: 455 ---------IPQELPCV--------AKDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTKK 497
IP+ P K+F+ CL ++ + +AK+L+ H F++ K
Sbjct: 234 LHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKT 293
Query: 498 PYV 500
Y+
Sbjct: 294 SYL 296
Score = 38.3 bits (85), Expect = 0.22
Identities = 21/71 (29%), Positives = 39/71 (54%), Gaps = 1/71 (1%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENV 595
F L +GKG+FG+V K + AIK + L ++ + I +E+ +LS+ + V
Sbjct: 36 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEI-EDIQQEITVLSQCDSPYV 94
Query: 596 VRYYNAWIEST 606
+YY ++++ T
Sbjct: 95 TKYYGSYLKDT 105
>AL139082-5|CAI12892.2| 708|Homo sapiens NIMA (never in mitosis
gene a)-related kinase 5 protein.
Length = 708
Score = 74.5 bits (175), Expect = 3e-12
Identities = 52/139 (37%), Positives = 75/139 (53%), Gaps = 22/139 (15%)
Query: 716 LYIQMEFCEKHTLRQAIDNG---LFQE-HFRAWRLFREIVEGLAHVHQRGMIHRDLKPVN 771
L+I ME+C+ L + I+ LF E W F +I GL H+H R ++HRD+K N
Sbjct: 76 LFIVMEYCDGGDLMKRINRQRGVLFSEDQILGW--FVQISLGLKHIHDRKILHRDIKAQN 133
Query: 772 IFLDSNDHV-KIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATK 830
IFL N V K+GDFG+A + E+ + IGT Y++PE+ Q+
Sbjct: 134 IFLSKNGMVAKLGDFGIARVLNNSM---------ELARTC---IGTPYYLSPEICQNKP- 180
Query: 831 VIYNQKVDIYSLGIILFEM 849
YN K DI+SLG +L+E+
Sbjct: 181 --YNNKTDIWSLGCVLYEL 197
Score = 48.4 bits (110), Expect = 2e-04
Identities = 21/71 (29%), Positives = 39/71 (54%)
Query: 535 EFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHEN 594
+++V+ +G+GAFG K K D IK + +Q + +EV LL ++ H N
Sbjct: 3 KYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHPN 62
Query: 595 VVRYYNAWIES 605
+V ++N++ E+
Sbjct: 63 IVAFFNSFQEN 73
Score = 35.9 bits (79), Expect = 1.2
Identities = 30/119 (25%), Positives = 55/119 (46%), Gaps = 15/119 (12%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSG--FSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVR 393
++I + G L + + G FS+ ++LG ++ G L +H I+HRD++
Sbjct: 76 LFIVMEYCDGGDLMKRINRQRGVLFSED-QILGWFVQISLG----LKHIHDRKILHRDIK 130
Query: 394 SENVFVDDVGQVKLVGASLDTRLAEMLDNDNYCDKQTPAQDIYATGQLLLSIVCKEKSY 452
++N+F+ G V +G D +A +L+N A+ T L +C+ K Y
Sbjct: 131 AQNIFLSKNGMVAKLG---DFGIARVLNN-----SMELARTCIGTPYYLSPEICQNKPY 181
>AL137249-7|CAI39457.1| 431|Homo sapiens serine/threonine kinase 24
(STE20 homolog, yeast) protein.
Length = 431
Score = 74.5 bits (175), Expect = 3e-12
Identities = 67/243 (27%), Positives = 113/243 (46%), Gaps = 26/243 (10%)
Query: 680 ELIEFEKTSDDEES--QTLPSEDVVDAP---RPQSERLKQV-LYIQMEFCEKHTLRQAID 733
++I+ E+ D+ E Q + D+P + LK L+I ME+ + ++
Sbjct: 53 KIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE 112
Query: 734 NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFT 793
G E A + REI++GL ++H IHRD+K N+ L + VK+ DFG+A
Sbjct: 113 PGPLDETQIA-TILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVA----- 166
Query: 794 GLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH-P 852
G + + K+ +GT ++APE+++ + Y+ K DI+SLGI E+
Sbjct: 167 GQLTDTQIKRNTF-------VGTPFWMAPEVIKQSA---YDSKADIWSLGITAIELARGE 216
Query: 853 PLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEH 912
P + + M VL + + P + + + + LN E S RPT ELL +
Sbjct: 217 PPHSELHPMKVLFLIPKNN---PPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKF 273
Query: 913 VPR 915
+ R
Sbjct: 274 ILR 276
Score = 40.7 bits (91), Expect = 0.041
Identities = 53/243 (21%), Positives = 105/243 (43%), Gaps = 45/243 (18%)
Query: 289 DFQTRNKQLTSIQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSL 348
D + ++ IQQ++ L++ + PYV K ++I ++ G S
Sbjct: 56 DLEEAEDEIEDIQQEITVLSQCDS----PYVT----KYYGSYLKDTKLWIIMEYLGGGSA 107
Query: 349 KNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLV 408
+L++ G D ++ +LR + G L+ LH+ IHRD+++ NV + + G+VKL
Sbjct: 108 LDLLEP--GPLDETQIATILREILKG----LDYLHSEKKIHRDIKAANVLLSEHGEVKLA 161
Query: 409 GASLDTRLAE-MLDNDNYCD----------KQT---PAQDIYATGQLLLSIVCKEKSYTE 454
+ +L + + + + KQ+ DI++ G + + E ++E
Sbjct: 162 DFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSE 221
Query: 455 ---------IPQELPCV--------AKDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTKK 497
IP+ P K+F+ CL ++ + +AK+L+ H F++ K
Sbjct: 222 LHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKT 281
Query: 498 PYV 500
Y+
Sbjct: 282 SYL 284
Score = 38.3 bits (85), Expect = 0.22
Identities = 21/71 (29%), Positives = 39/71 (54%), Gaps = 1/71 (1%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENV 595
F L +GKG+FG+V K + AIK + L ++ + I +E+ +LS+ + V
Sbjct: 24 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEI-EDIQQEITVLSQCDSPYV 82
Query: 596 VRYYNAWIEST 606
+YY ++++ T
Sbjct: 83 TKYYGSYLKDT 93
>AL137249-3|CAI39453.1| 443|Homo sapiens serine/threonine kinase 24
(STE20 homolog, yeast) protein.
Length = 443
Score = 74.5 bits (175), Expect = 3e-12
Identities = 67/243 (27%), Positives = 113/243 (46%), Gaps = 26/243 (10%)
Query: 680 ELIEFEKTSDDEES--QTLPSEDVVDAP---RPQSERLKQV-LYIQMEFCEKHTLRQAID 733
++I+ E+ D+ E Q + D+P + LK L+I ME+ + ++
Sbjct: 65 KIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE 124
Query: 734 NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFT 793
G E A + REI++GL ++H IHRD+K N+ L + VK+ DFG+A
Sbjct: 125 PGPLDETQIA-TILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVA----- 178
Query: 794 GLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH-P 852
G + + K+ +GT ++APE+++ + Y+ K DI+SLGI E+
Sbjct: 179 GQLTDTQIKRNTF-------VGTPFWMAPEVIKQSA---YDSKADIWSLGITAIELARGE 228
Query: 853 PLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEH 912
P + + M VL + + P + + + + LN E S RPT ELL +
Sbjct: 229 PPHSELHPMKVLFLIPKNN---PPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKF 285
Query: 913 VPR 915
+ R
Sbjct: 286 ILR 288
Score = 40.7 bits (91), Expect = 0.041
Identities = 53/243 (21%), Positives = 105/243 (43%), Gaps = 45/243 (18%)
Query: 289 DFQTRNKQLTSIQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSL 348
D + ++ IQQ++ L++ + PYV K ++I ++ G S
Sbjct: 68 DLEEAEDEIEDIQQEITVLSQCDS----PYVT----KYYGSYLKDTKLWIIMEYLGGGSA 119
Query: 349 KNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLV 408
+L++ G D ++ +LR + G L+ LH+ IHRD+++ NV + + G+VKL
Sbjct: 120 LDLLEP--GPLDETQIATILREILKG----LDYLHSEKKIHRDIKAANVLLSEHGEVKLA 173
Query: 409 GASLDTRLAE-MLDNDNYCD----------KQT---PAQDIYATGQLLLSIVCKEKSYTE 454
+ +L + + + + KQ+ DI++ G + + E ++E
Sbjct: 174 DFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSE 233
Query: 455 ---------IPQELPCV--------AKDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTKK 497
IP+ P K+F+ CL ++ + +AK+L+ H F++ K
Sbjct: 234 LHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKT 293
Query: 498 PYV 500
Y+
Sbjct: 294 SYL 296
Score = 38.3 bits (85), Expect = 0.22
Identities = 21/71 (29%), Positives = 39/71 (54%), Gaps = 1/71 (1%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENV 595
F L +GKG+FG+V K + AIK + L ++ + I +E+ +LS+ + V
Sbjct: 36 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEI-EDIQQEITVLSQCDSPYV 94
Query: 596 VRYYNAWIEST 606
+YY ++++ T
Sbjct: 95 TKYYGSYLKDT 105
>AK093251-1|BAC04109.1| 514|Homo sapiens protein ( Homo sapiens
cDNA FLJ35932 fis, clone TESTI2011286, weakly similar to
MYOSIN LIGHT CHAIN KINASE (EC 2.7.1.117). ).
Length = 514
Score = 74.5 bits (175), Expect = 3e-12
Identities = 59/211 (27%), Positives = 108/211 (51%), Gaps = 34/211 (16%)
Query: 716 LYIQMEFCEKHTLRQAIDN-GLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
+Y+ ME CE L++ +D G F E+ W + + + +A++H ++HRDLK NI +
Sbjct: 188 MYLVMELCEDGELKEILDRKGHFSENETRW-IIQSLASAIAYLHNNDIVHRDLKLENIMV 246
Query: 775 ------DSND---HVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELL 825
D+N+ ++K+ DFGLA K KQ L GT +Y+APE++
Sbjct: 247 KSSLIDDNNEINLNIKVTDFGLAVK-----------KQSRSEAMLQATCGTPIYMAPEVI 295
Query: 826 QSATKVIYNQKVDIYSLGIILFEMF--HPP-LETGMERMMVLTNLRSKDIVIPNKF--DV 880
+ Y+Q+ DI+S+G++++ + PP L + E++ L +R ++ N +
Sbjct: 296 SAHD---YSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFEL--IRKGELHFENAVWNSI 350
Query: 881 DENVKQIHVIRWLLNHEASLRPTCAELLASE 911
+ K V++ L+ + + R T ELL ++
Sbjct: 351 SDCAKS--VLKQLMKVDPAHRITAKELLDNQ 379
Score = 39.5 bits (88), Expect = 0.094
Identities = 25/105 (23%), Positives = 47/105 (44%), Gaps = 2/105 (1%)
Query: 492 EAPTKKPYVKRAXXXXXXXXXXXAVKKIRHMSFANNGLSRLDAEFEVLAWLGKGAFGDVL 551
+ P++ V+R K+ H+ N + ++ + LGKG+FG V+
Sbjct: 74 DLPSRTSNVERKASQQQWGRGNFTEGKVPHIRIENG--AAIEEIYTFGRILGKGSFGIVI 131
Query: 552 KVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENVV 596
+ +K +AIK+V K + REV +L + HE+++
Sbjct: 132 EATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHII 176
Score = 33.1 bits (72), Expect = 8.1
Identities = 35/153 (22%), Positives = 67/153 (43%), Gaps = 20/153 (13%)
Query: 248 KKVY-IGSCLGHSSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKS 306
+++Y G LG S G A D +T KW+I + + + + ++++V
Sbjct: 113 EEIYTFGRILGKGSFGIVIE-ATDKET-----ETKWAIKKVNKEKAGSSAVKLLEREVNI 166
Query: 307 LARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLG 366
L + + +I +E E K+ +Y+ LK ++ + FS+
Sbjct: 167 LKSVKHEHIIH---LEQVFETPKK-----MYLVMELCEDGELKEILDRKGHFSE-----N 213
Query: 367 LLRHVADGVLSALNELHAANIIHRDVRSENVFV 399
R + + SA+ LH +I+HRD++ EN+ V
Sbjct: 214 ETRWIIQSLASAIAYLHNNDIVHRDLKLENIMV 246
>AJ303380-1|CAC29064.1| 514|Homo sapiens serine/threonine kinase 33
protein.
Length = 514
Score = 74.5 bits (175), Expect = 3e-12
Identities = 59/211 (27%), Positives = 108/211 (51%), Gaps = 34/211 (16%)
Query: 716 LYIQMEFCEKHTLRQAIDN-GLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
+Y+ ME CE L++ +D G F E+ W + + + +A++H ++HRDLK NI +
Sbjct: 188 MYLVMELCEDGELKEILDRKGHFSENETRW-IIQSLASAIAYLHNNDIVHRDLKLENIMV 246
Query: 775 ------DSND---HVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELL 825
D+N+ ++K+ DFGLA K KQ L GT +Y+APE++
Sbjct: 247 KSSLIDDNNEINLNIKVTDFGLAVK-----------KQSRSEAMLQATCGTPIYMAPEVI 295
Query: 826 QSATKVIYNQKVDIYSLGIILFEMF--HPP-LETGMERMMVLTNLRSKDIVIPNKF--DV 880
+ Y+Q+ DI+S+G++++ + PP L + E++ L +R ++ N +
Sbjct: 296 SAHD---YSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFEL--IRKGELHFENAVWNSI 350
Query: 881 DENVKQIHVIRWLLNHEASLRPTCAELLASE 911
+ K V++ L+ + + R T ELL ++
Sbjct: 351 SDCAKS--VLKQLMKVDPAHRITAKELLDNQ 379
Score = 39.5 bits (88), Expect = 0.094
Identities = 25/105 (23%), Positives = 47/105 (44%), Gaps = 2/105 (1%)
Query: 492 EAPTKKPYVKRAXXXXXXXXXXXAVKKIRHMSFANNGLSRLDAEFEVLAWLGKGAFGDVL 551
+ P++ V+R K+ H+ N + ++ + LGKG+FG V+
Sbjct: 74 DLPSRTSNVERKASQQQWGRGNFTEGKVPHIRIENG--AAIEEIYTFGRILGKGSFGIVI 131
Query: 552 KVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENVV 596
+ +K +AIK+V K + REV +L + HE+++
Sbjct: 132 EATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHII 176
Score = 33.1 bits (72), Expect = 8.1
Identities = 35/153 (22%), Positives = 67/153 (43%), Gaps = 20/153 (13%)
Query: 248 KKVY-IGSCLGHSSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKS 306
+++Y G LG S G A D +T KW+I + + + + ++++V
Sbjct: 113 EEIYTFGRILGKGSFGIVIE-ATDKET-----ETKWAIKKVNKEKAGSSAVKLLEREVNI 166
Query: 307 LARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLG 366
L + + +I +E E K+ +Y+ LK ++ + FS+
Sbjct: 167 LKSVKHEHIIH---LEQVFETPKK-----MYLVMELCEDGELKEILDRKGHFSE-----N 213
Query: 367 LLRHVADGVLSALNELHAANIIHRDVRSENVFV 399
R + + SA+ LH +I+HRD++ EN+ V
Sbjct: 214 ETRWIIQSLASAIAYLHNNDIVHRDLKLENIMV 246
>AF445413-2|AAN75850.1| 873|Homo sapiens MAP4K3 protein.
Length = 873
Score = 74.5 bits (175), Expect = 3e-12
Identities = 59/211 (27%), Positives = 102/211 (48%), Gaps = 24/211 (11%)
Query: 716 LYIQMEFCEKHTLRQAID-NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
L+I MEFC +L+ G E A+ + RE ++GL ++H +G +HRD+K NI L
Sbjct: 86 LWICMEFCGGGSLQDIYHVTGPLSELQIAY-VSRETLQGLYYLHSKGKMHRDIKGANILL 144
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
N HVK+ DFG++ + + K++ IGT ++APE+ K YN
Sbjct: 145 TDNGHVKLADFGVSAQITATI-----AKRKSF-------IGTPYWMAPEVAAVERKGGYN 192
Query: 835 QKVDIYSLGIILFEM--FHPPLET--GMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVI 890
Q D++++GI E+ PP+ M + ++T + + +K + H +
Sbjct: 193 QLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFH--HFV 250
Query: 891 RWLLNHEASLRPTCAELL----ASEHVPRAV 917
+ L RPT +LL ++H+ R++
Sbjct: 251 KMALTKNPKKRPTAEKLLQHPFVTQHLTRSL 281
Score = 44.0 bits (99), Expect = 0.004
Identities = 21/70 (30%), Positives = 40/70 (57%), Gaps = 4/70 (5%)
Query: 535 EFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNP-ESVQLNKKITREVKLLSRLNHE 593
+FE++ +G G +GDV K +N G AIK ++L P E + + +E+ ++ H
Sbjct: 15 DFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV---VQQEIIMMKDCKHP 71
Query: 594 NVVRYYNAWI 603
N+V Y+ +++
Sbjct: 72 NIVAYFGSYL 81
Score = 38.7 bits (86), Expect = 0.16
Identities = 36/158 (22%), Positives = 66/158 (41%), Gaps = 20/158 (12%)
Query: 259 SSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSNASLIPY 318
S T Y A + +TGE K + P DF +QQ++ + + +++ Y
Sbjct: 24 SGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV-------VQQEIIMMKDCKHPNIVAY 76
Query: 319 VAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSA 378
+ R K ++I F G SL+++ S+ + +V+ L
Sbjct: 77 FGSYL------RRDK--LWICMEFCGGGSLQDIYHVTGPLSEL-----QIAYVSRETLQG 123
Query: 379 LNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRL 416
L LH+ +HRD++ N+ + D G VKL + ++
Sbjct: 124 LYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQI 161
>AF445413-1|AAN75849.1| 894|Homo sapiens MAP4K3 protein.
Length = 894
Score = 74.5 bits (175), Expect = 3e-12
Identities = 59/211 (27%), Positives = 102/211 (48%), Gaps = 24/211 (11%)
Query: 716 LYIQMEFCEKHTLRQAID-NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
L+I MEFC +L+ G E A+ + RE ++GL ++H +G +HRD+K NI L
Sbjct: 86 LWICMEFCGGGSLQDIYHVTGPLSELQIAY-VSRETLQGLYYLHSKGKMHRDIKGANILL 144
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
N HVK+ DFG++ + + K++ IGT ++APE+ K YN
Sbjct: 145 TDNGHVKLADFGVSAQITATI-----AKRKSF-------IGTPYWMAPEVAAVERKGGYN 192
Query: 835 QKVDIYSLGIILFEM--FHPPLET--GMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVI 890
Q D++++GI E+ PP+ M + ++T + + +K + H +
Sbjct: 193 QLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFH--HFV 250
Query: 891 RWLLNHEASLRPTCAELL----ASEHVPRAV 917
+ L RPT +LL ++H+ R++
Sbjct: 251 KMALTKNPKKRPTAEKLLQHPFVTQHLTRSL 281
Score = 44.0 bits (99), Expect = 0.004
Identities = 21/70 (30%), Positives = 40/70 (57%), Gaps = 4/70 (5%)
Query: 535 EFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNP-ESVQLNKKITREVKLLSRLNHE 593
+FE++ +G G +GDV K +N G AIK ++L P E + + +E+ ++ H
Sbjct: 15 DFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV---VQQEIIMMKDCKHP 71
Query: 594 NVVRYYNAWI 603
N+V Y+ +++
Sbjct: 72 NIVAYFGSYL 81
Score = 38.7 bits (86), Expect = 0.16
Identities = 36/158 (22%), Positives = 66/158 (41%), Gaps = 20/158 (12%)
Query: 259 SSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSNASLIPY 318
S T Y A + +TGE K + P DF +QQ++ + + +++ Y
Sbjct: 24 SGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV-------VQQEIIMMKDCKHPNIVAY 76
Query: 319 VAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSA 378
+ R K ++I F G SL+++ S+ + +V+ L
Sbjct: 77 FGSYL------RRDK--LWICMEFCGGGSLQDIYHVTGPLSEL-----QIAYVSRETLQG 123
Query: 379 LNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRL 416
L LH+ +HRD++ N+ + D G VKL + ++
Sbjct: 124 LYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQI 161
>AF083420-1|AAD42039.1| 443|Homo sapiens brain-specific STE20-like
protein kinase 3 protein.
Length = 443
Score = 74.5 bits (175), Expect = 3e-12
Identities = 67/243 (27%), Positives = 113/243 (46%), Gaps = 26/243 (10%)
Query: 680 ELIEFEKTSDDEES--QTLPSEDVVDAP---RPQSERLKQV-LYIQMEFCEKHTLRQAID 733
++I+ E+ D+ E Q + D+P + LK L+I ME+ + ++
Sbjct: 65 KIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE 124
Query: 734 NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFT 793
G E A + REI++GL ++H IHRD+K N+ L + VK+ DFG+A
Sbjct: 125 PGPLDETQIA-TILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVA----- 178
Query: 794 GLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH-P 852
G + + K+ +GT ++APE+++ + Y+ K DI+SLGI E+
Sbjct: 179 GQLTDTQIKRNTF-------VGTPFWMAPEVIKQSA---YDSKADIWSLGITAIELARGE 228
Query: 853 PLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEH 912
P + + M VL + + P + + + + LN E S RPT ELL +
Sbjct: 229 PPHSELHPMKVLFLIPKNN---PPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKF 285
Query: 913 VPR 915
+ R
Sbjct: 286 ILR 288
Score = 40.7 bits (91), Expect = 0.041
Identities = 53/243 (21%), Positives = 105/243 (43%), Gaps = 45/243 (18%)
Query: 289 DFQTRNKQLTSIQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSL 348
D + ++ IQQ++ L++ + PYV K ++I ++ G S
Sbjct: 68 DLEEAEDEIEDIQQEITVLSQCDS----PYVT----KYYGSYLKDTKLWIIMEYLGGGSA 119
Query: 349 KNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLV 408
+L++ G D ++ +LR + G L+ LH+ IHRD+++ NV + + G+VKL
Sbjct: 120 LDLLEP--GPLDETQIATILREILKG----LDYLHSEKKIHRDIKAANVLLSEHGEVKLA 173
Query: 409 GASLDTRLAE-MLDNDNYCD----------KQT---PAQDIYATGQLLLSIVCKEKSYTE 454
+ +L + + + + KQ+ DI++ G + + E ++E
Sbjct: 174 DFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSE 233
Query: 455 ---------IPQELPCV--------AKDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTKK 497
IP+ P K+F+ CL ++ + +AK+L+ H F++ K
Sbjct: 234 LHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKT 293
Query: 498 PYV 500
Y+
Sbjct: 294 SYL 296
Score = 38.3 bits (85), Expect = 0.22
Identities = 21/71 (29%), Positives = 39/71 (54%), Gaps = 1/71 (1%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENV 595
F L +GKG+FG+V K + AIK + L ++ + I +E+ +LS+ + V
Sbjct: 36 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEI-EDIQQEITVLSQCDSPYV 94
Query: 596 VRYYNAWIEST 606
+YY ++++ T
Sbjct: 95 TKYYGSYLKDT 105
>AF024636-1|AAB82560.1| 431|Homo sapiens STE20-like kinase 3
protein.
Length = 431
Score = 74.5 bits (175), Expect = 3e-12
Identities = 67/243 (27%), Positives = 113/243 (46%), Gaps = 26/243 (10%)
Query: 680 ELIEFEKTSDDEES--QTLPSEDVVDAP---RPQSERLKQV-LYIQMEFCEKHTLRQAID 733
++I+ E+ D+ E Q + D+P + LK L+I ME+ + ++
Sbjct: 53 KIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE 112
Query: 734 NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFT 793
G E A + REI++GL ++H IHRD+K N+ L + VK+ DFG+A
Sbjct: 113 PGPLDETQIA-TILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVA----- 166
Query: 794 GLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH-P 852
G + + K+ +GT ++APE+++ + Y+ K DI+SLGI E+
Sbjct: 167 GQLTDTQIKRNTF-------VGTPFWMAPEVIKQSA---YDSKADIWSLGITAIELARGE 216
Query: 853 PLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEH 912
P + + M VL + + P + + + + LN E S RPT ELL +
Sbjct: 217 PPHSELHPMKVLFLIPKNN---PPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKF 273
Query: 913 VPR 915
+ R
Sbjct: 274 ILR 276
Score = 40.7 bits (91), Expect = 0.041
Identities = 53/243 (21%), Positives = 105/243 (43%), Gaps = 45/243 (18%)
Query: 289 DFQTRNKQLTSIQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSL 348
D + ++ IQQ++ L++ + PYV K ++I ++ G S
Sbjct: 56 DLEEAEDEIEDIQQEITVLSQCDS----PYVT----KYYGSYLKDTKLWIIMEYLGGGSA 107
Query: 349 KNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLV 408
+L++ G D ++ +LR + G L+ LH+ IHRD+++ NV + + G+VKL
Sbjct: 108 LDLLEP--GPLDETQIATILREILKG----LDYLHSEKKIHRDIKAANVLLSEHGEVKLA 161
Query: 409 GASLDTRLAE-MLDNDNYCD----------KQT---PAQDIYATGQLLLSIVCKEKSYTE 454
+ +L + + + + KQ+ DI++ G + + E ++E
Sbjct: 162 DFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSE 221
Query: 455 ---------IPQELPCV--------AKDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTKK 497
IP+ P K+F+ CL ++ + +AK+L+ H F++ K
Sbjct: 222 LHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKT 281
Query: 498 PYV 500
Y+
Sbjct: 282 SYL 284
Score = 38.3 bits (85), Expect = 0.22
Identities = 21/71 (29%), Positives = 39/71 (54%), Gaps = 1/71 (1%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENV 595
F L +GKG+FG+V K + AIK + L ++ + I +E+ +LS+ + V
Sbjct: 24 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEI-EDIQQEITVLSQCDSPYV 82
Query: 596 VRYYNAWIEST 606
+YY ++++ T
Sbjct: 83 TKYYGSYLKDT 93
>AF000145-1|AAC15472.1| 884|Homo sapiens germinal center kinase
related protein kinase protein.
Length = 884
Score = 74.5 bits (175), Expect = 3e-12
Identities = 59/211 (27%), Positives = 102/211 (48%), Gaps = 24/211 (11%)
Query: 716 LYIQMEFCEKHTLRQAID-NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
L+I MEFC +L+ G E A+ + RE ++GL ++H +G +HRD+K NI L
Sbjct: 76 LWICMEFCGGGSLQDIYHVTGPLSELQIAY-VSRETLQGLYYLHSKGKMHRDIKGANILL 134
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
N HVK+ DFG++ + + K++ IGT ++APE+ K YN
Sbjct: 135 TDNGHVKLADFGVSAQITATI-----AKRKSF-------IGTPYWMAPEVAAVERKGGYN 182
Query: 835 QKVDIYSLGIILFEM--FHPPLET--GMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVI 890
Q D++++GI E+ PP+ M + ++T + + +K + H +
Sbjct: 183 QLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFH--HFV 240
Query: 891 RWLLNHEASLRPTCAELL----ASEHVPRAV 917
+ L RPT +LL ++H+ R++
Sbjct: 241 KMALTKNPKKRPTAEKLLQHPFVTQHLTRSL 271
Score = 44.0 bits (99), Expect = 0.004
Identities = 21/70 (30%), Positives = 40/70 (57%), Gaps = 4/70 (5%)
Query: 535 EFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNP-ESVQLNKKITREVKLLSRLNHE 593
+FE++ +G G +GDV K +N G AIK ++L P E + + +E+ ++ H
Sbjct: 5 DFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV---VQQEIIMMKDCKHP 61
Query: 594 NVVRYYNAWI 603
N+V Y+ +++
Sbjct: 62 NIVAYFGSYL 71
Score = 38.7 bits (86), Expect = 0.16
Identities = 36/158 (22%), Positives = 66/158 (41%), Gaps = 20/158 (12%)
Query: 259 SSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSNASLIPY 318
S T Y A + +TGE K + P DF +QQ++ + + +++ Y
Sbjct: 14 SGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV-------VQQEIIMMKDCKHPNIVAY 66
Query: 319 VAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSA 378
+ R K ++I F G SL+++ S+ + +V+ L
Sbjct: 67 FGSYL------RRDK--LWICMEFCGGGSLQDIYHVTGPLSEL-----QIAYVSRETLQG 113
Query: 379 LNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRL 416
L LH+ +HRD++ N+ + D G VKL + ++
Sbjct: 114 LYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQI 151
>AC007684-1|AAF19240.1| 712|Homo sapiens unknown protein.
Length = 712
Score = 74.5 bits (175), Expect = 3e-12
Identities = 59/211 (27%), Positives = 102/211 (48%), Gaps = 24/211 (11%)
Query: 716 LYIQMEFCEKHTLRQAID-NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
L+I MEFC +L+ G E A+ + RE ++GL ++H +G +HRD+K NI L
Sbjct: 86 LWICMEFCGGGSLQDIYHVTGPLSELQIAY-VSRETLQGLYYLHSKGKMHRDIKGANILL 144
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
N HVK+ DFG++ + + K++ IGT ++APE+ K YN
Sbjct: 145 TDNGHVKLADFGVSAQITATI-----AKRKSF-------IGTPYWMAPEVAAVERKGGYN 192
Query: 835 QKVDIYSLGIILFEM--FHPPLET--GMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVI 890
Q D++++GI E+ PP+ M + ++T + + +K + H +
Sbjct: 193 QLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFH--HFV 250
Query: 891 RWLLNHEASLRPTCAELL----ASEHVPRAV 917
+ L RPT +LL ++H+ R++
Sbjct: 251 KMALTKNPKKRPTAEKLLQHPFVTQHLTRSL 281
Score = 44.0 bits (99), Expect = 0.004
Identities = 21/70 (30%), Positives = 40/70 (57%), Gaps = 4/70 (5%)
Query: 535 EFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNP-ESVQLNKKITREVKLLSRLNHE 593
+FE++ +G G +GDV K +N G AIK ++L P E + + +E+ ++ H
Sbjct: 15 DFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV---VQQEIIMMKDCKHP 71
Query: 594 NVVRYYNAWI 603
N+V Y+ +++
Sbjct: 72 NIVAYFGSYL 81
Score = 38.7 bits (86), Expect = 0.16
Identities = 36/158 (22%), Positives = 66/158 (41%), Gaps = 20/158 (12%)
Query: 259 SSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSNASLIPY 318
S T Y A + +TGE K + P DF +QQ++ + + +++ Y
Sbjct: 24 SGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV-------VQQEIIMMKDCKHPNIVAY 76
Query: 319 VAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSA 378
+ R K ++I F G SL+++ S+ + +V+ L
Sbjct: 77 FGSYL------RRDK--LWICMEFCGGGSLQDIYHVTGPLSEL-----QIAYVSRETLQG 123
Query: 379 LNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRL 416
L LH+ +HRD++ N+ + D G VKL + ++
Sbjct: 124 LYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQI 161
>U63973-1|AAB05929.1| 563|Homo sapiens rhodopsin kinase protein.
Length = 563
Score = 74.1 bits (174), Expect = 4e-12
Identities = 42/101 (41%), Positives = 62/101 (61%), Gaps = 15/101 (14%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
+I+ GL H+HQR +++RDLKP N+ LD++ +V+I D GLA + G + KTK
Sbjct: 300 QIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDG---QSKTK------ 350
Query: 809 SLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEM 849
G GT ++APELLQ Y+ VD ++LG+ L+EM
Sbjct: 351 ---GYAGTPGFMAPELLQGEE---YDFSVDYFALGVTLYEM 385
Score = 35.1 bits (77), Expect = 2.0
Identities = 14/44 (31%), Positives = 25/44 (56%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAE 418
++ L LH I++RD++ ENV +D+ G V++ L L +
Sbjct: 301 IICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLD 344
>L77503-1|AAG50439.1| 563|Homo sapiens rhodopsin kinase protein.
Length = 563
Score = 74.1 bits (174), Expect = 4e-12
Identities = 42/101 (41%), Positives = 62/101 (61%), Gaps = 15/101 (14%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
+I+ GL H+HQR +++RDLKP N+ LD++ +V+I D GLA + G + KTK
Sbjct: 300 QIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDG---QSKTK------ 350
Query: 809 SLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEM 849
G GT ++APELLQ Y+ VD ++LG+ L+EM
Sbjct: 351 ---GYAGTPGFMAPELLQGEE---YDFSVDYFALGVTLYEM 385
Score = 35.1 bits (77), Expect = 2.0
Identities = 14/44 (31%), Positives = 25/44 (56%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAE 418
++ L LH I++RD++ ENV +D+ G V++ L L +
Sbjct: 301 IICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLD 344
>L77502-1|AAT00534.2| 563|Homo sapiens rhodopsin kinase protein.
Length = 563
Score = 74.1 bits (174), Expect = 4e-12
Identities = 42/101 (41%), Positives = 62/101 (61%), Gaps = 15/101 (14%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
+I+ GL H+HQR +++RDLKP N+ LD++ +V+I D GLA + G + KTK
Sbjct: 300 QIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDG---QSKTK------ 350
Query: 809 SLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEM 849
G GT ++APELLQ Y+ VD ++LG+ L+EM
Sbjct: 351 ---GYAGTPGFMAPELLQGEE---YDFSVDYFALGVTLYEM 385
Score = 35.1 bits (77), Expect = 2.0
Identities = 14/44 (31%), Positives = 25/44 (56%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAE 418
++ L LH I++RD++ ENV +D+ G V++ L L +
Sbjct: 301 IICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLD 344
>AJ271722-1|CAB71146.1| 714|Homo sapiens putative serine/threonine
protein kinase MAK-V protein.
Length = 714
Score = 74.1 bits (174), Expect = 4e-12
Identities = 54/194 (27%), Positives = 88/194 (45%), Gaps = 13/194 (6%)
Query: 717 YIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDS 776
Y+ ME C L I E A R R+++ + H+H+ G++HRDLK N+ LD
Sbjct: 137 YLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDE 196
Query: 777 NDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQK 836
++++K+ DFGL+ A L D + Q G+ Y APELL + Y K
Sbjct: 197 DNNIKLIDFGLSNCAGI-LGYSD---------PFSTQCGSPAYAAPELL---ARKKYGPK 243
Query: 837 VDIYSLGIILFEMFHPPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNH 896
+D++S+G+ ++ M L +E + + N + I +R LL
Sbjct: 244 IDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEP 303
Query: 897 EASLRPTCAELLAS 910
+ RP + LA+
Sbjct: 304 DPVKRPNIQQALAN 317
Score = 39.1 bits (87), Expect = 0.12
Identities = 14/38 (36%), Positives = 26/38 (68%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASL 412
++SA+ LH A ++HRD++ EN+ +D+ +KL+ L
Sbjct: 170 LISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGL 207
>U18937-1|AAA73974.1| 506|Homo sapiens histidyl-tRNA synthetase
homologue protein.
Length = 506
Score = 73.7 bits (173), Expect = 5e-12
Identities = 79/354 (22%), Positives = 158/354 (44%), Gaps = 29/354 (8%)
Query: 971 EFVKDAVVKVFKSHGALEFAPPLLIPRARAWDQYPNAVKVM----TSSGSVCHLPHDLRL 1026
E + D V+ FK HGA P + ++Y +M G + L +DL +
Sbjct: 75 EKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSGLMYDLKDQGGELLSLRYDLTV 134
Query: 1027 PFARHIAYSGIKNLRRFIVDRVYREKH---VQGFHPKEILECAYDIVTPKTDSLWPDAEL 1083
PFAR++A + +K ++R+ V +V+R + VQG + +E +C +DI + D + PDAE
Sbjct: 135 PFARYLAMNKVKKMKRYHVGKVWRRESPTIVQGRY-REFCQCDFDI-AGQFDPMIPDAEC 192
Query: 1084 IEVASRAASECSL-KVSIQLNHTELIRVLLQSCGVPTDKQADI---YPVLVDVSFGRIXX 1139
+++ S L I++N ++ + CGVP K I L +++ +
Sbjct: 193 LKIMCEILSGLQLGDFLIKVNDRRIVDGMFAVCGVPESKFRAICSSIDKLDKMAWKDVRH 252
Query: 1140 XXXXXXXXXXCITNRDVTNLVRLMEADAPVQELRELVTPLVKQAKCSRIASQAVHDLEAV 1199
+ +R + + V+ + V+++ + P + Q ++ A + + DL+ +
Sbjct: 253 EMVVKKGLAPEVADR-IGDYVQCHGGVSLVEQMFQ--DPRLSQ---NKQALEGLGDLKLL 306
Query: 1200 YRNAKALGCECPMTVAPLSAYNVTQHSGVFWQMSVVRSEQKSITKRRSGDLIAAGGRYDA 1259
+ G ++ A + ++GV ++ ++++ ++ + + +AAGGRYD
Sbjct: 307 FEYLTLFGIADKISFDLSLARGLDYYTGVIYEAVLLQTPTQAGEEPLNVGSVAAGGRYDG 366
Query: 1260 LVKEFWNVASAENDQDSADLNVCSVGFSMSLERMAAFLNKLETQTNVPIKSNET 1313
LV F D V VG S+ +ER+ + + +++ ET
Sbjct: 367 LVGMF----------DPKGHKVPCVGLSIGVERIFYIVEQRMKTKGEKVRTTET 410
>BC047865-1|AAH47865.1| 812|Homo sapiens MAP4K2 protein protein.
Length = 812
Score = 73.7 bits (173), Expect = 5e-12
Identities = 62/211 (29%), Positives = 102/211 (48%), Gaps = 24/211 (11%)
Query: 716 LYIQMEFCEKHTLRQAID-NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
L+I MEFC +L++ G +E A+ + RE ++GL H+H +G IHRD+K N+ L
Sbjct: 86 LWICMEFCGGGSLQEIYHATGPLEERQIAY-VCREALKGLHHLHSQGKIHRDIKGANLLL 144
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
VK+ DFG+ +G K+ IGT ++APE+ K YN
Sbjct: 145 TLQGDVKLADFGV-----SGELTASVAKRRSF-------IGTPYWMAPEVAAVERKGGYN 192
Query: 835 QKVDIYSLGIILFEM--FHPPL--ETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVI 890
+ D+++LGI E+ PPL M +M+++ + + +K +N H +
Sbjct: 193 ELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFH--HFL 250
Query: 891 RWLLNHEASLRPTCAELL----ASEHVPRAV 917
+ L RPT +LL ++ +PRA+
Sbjct: 251 KLALTKNPKKRPTAEKLLQHPFTTQQLPRAL 281
Score = 42.3 bits (95), Expect = 0.013
Identities = 21/70 (30%), Positives = 38/70 (54%), Gaps = 2/70 (2%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENV 595
FE+L +G G +GDV K ++ + A+K V+L+P + +E+ +L H NV
Sbjct: 16 FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDD--ISSLQQEITILRECRHPNV 73
Query: 596 VRYYNAWIES 605
V Y +++ +
Sbjct: 74 VAYIGSYLRN 83
Score = 34.7 bits (76), Expect = 2.7
Identities = 35/149 (23%), Positives = 61/149 (40%), Gaps = 20/149 (13%)
Query: 259 SSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSNASLIPY 318
+ T Y A D T E K + P D ++S+QQ++ L + +++ Y
Sbjct: 24 AGTYGDVYKARDTVTSELAAVKIVKLDPGDD-------ISSLQQEITILRECRHPNVVAY 76
Query: 319 VAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSA 378
+ + N R ++I F G SL+ + + + +V L
Sbjct: 77 IGSYLR---NDR-----LWICMEFCGGGSLQEIYHATGPLEE-----RQIAYVCREALKG 123
Query: 379 LNELHAANIIHRDVRSENVFVDDVGQVKL 407
L+ LH+ IHRD++ N+ + G VKL
Sbjct: 124 LHHLHSQGKIHRDIKGANLLLTLQGDVKL 152
>BC014982-1|AAH14982.1| 506|Homo sapiens histidyl-tRNA synthetase 2,
mitochondrial (putative) protein.
Length = 506
Score = 73.7 bits (173), Expect = 5e-12
Identities = 79/354 (22%), Positives = 158/354 (44%), Gaps = 29/354 (8%)
Query: 971 EFVKDAVVKVFKSHGALEFAPPLLIPRARAWDQYPNAVKVM----TSSGSVCHLPHDLRL 1026
E + D V+ FK HGA P + ++Y +M G + L +DL +
Sbjct: 75 EKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSGLMYDLKDQGGELLSLRYDLTV 134
Query: 1027 PFARHIAYSGIKNLRRFIVDRVYREKH---VQGFHPKEILECAYDIVTPKTDSLWPDAEL 1083
PFAR++A + +K ++R+ V +V+R + VQG + +E +C +DI + D + PDAE
Sbjct: 135 PFARYLAMNKVKKMKRYHVGKVWRRESPTIVQGRY-REFCQCDFDI-AGQFDPMIPDAEC 192
Query: 1084 IEVASRAASECSL-KVSIQLNHTELIRVLLQSCGVPTDKQADI---YPVLVDVSFGRIXX 1139
+++ S L I++N ++ + CGVP K I L +++ +
Sbjct: 193 LKIMCEILSGLQLGDFLIKVNDRRIVDGMFAVCGVPESKFRAICSSIDKLDKMAWKDVRH 252
Query: 1140 XXXXXXXXXXCITNRDVTNLVRLMEADAPVQELRELVTPLVKQAKCSRIASQAVHDLEAV 1199
+ +R + + V+ + V+++ + P + Q ++ A + + DL+ +
Sbjct: 253 EMVVKKGLAPEVADR-IGDYVQCHGGVSLVEQMFQ--DPRLSQ---NKQALEGLGDLKLL 306
Query: 1200 YRNAKALGCECPMTVAPLSAYNVTQHSGVFWQMSVVRSEQKSITKRRSGDLIAAGGRYDA 1259
+ G ++ A + ++GV ++ ++++ ++ + + +AAGGRYD
Sbjct: 307 FEYLTLFGIADKISFDLSLARGLDYYTGVIYEAVLLQTPTQAGEEPLNVGSVAAGGRYDG 366
Query: 1260 LVKEFWNVASAENDQDSADLNVCSVGFSMSLERMAAFLNKLETQTNVPIKSNET 1313
LV F D V VG S+ +ER+ + + +++ ET
Sbjct: 367 LVGMF----------DPKGHKVPCVGLSIGVERIFYIVEQRMKTKGEKVRTTET 410
>BC007680-1|AAH07680.1| 506|Homo sapiens histidyl-tRNA synthetase 2,
mitochondrial (putative) protein.
Length = 506
Score = 73.7 bits (173), Expect = 5e-12
Identities = 79/354 (22%), Positives = 158/354 (44%), Gaps = 29/354 (8%)
Query: 971 EFVKDAVVKVFKSHGALEFAPPLLIPRARAWDQYPNAVKVM----TSSGSVCHLPHDLRL 1026
E + D V+ FK HGA P + ++Y +M G + L +DL +
Sbjct: 75 EKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSGLMYDLKDQGGELLSLRYDLTV 134
Query: 1027 PFARHIAYSGIKNLRRFIVDRVYREKH---VQGFHPKEILECAYDIVTPKTDSLWPDAEL 1083
PFAR++A + +K ++R+ V +V+R + VQG + +E +C +DI + D + PDAE
Sbjct: 135 PFARYLAMNKVKKMKRYHVGKVWRRESPTIVQGRY-REFCQCDFDI-AGQFDPMIPDAEC 192
Query: 1084 IEVASRAASECSL-KVSIQLNHTELIRVLLQSCGVPTDKQADI---YPVLVDVSFGRIXX 1139
+++ S L I++N ++ + CGVP K I L +++ +
Sbjct: 193 LKIMCEILSGLQLGDFLIKVNDRRIVDGMFAVCGVPESKFRAICSSIDKLDKMAWKDVRH 252
Query: 1140 XXXXXXXXXXCITNRDVTNLVRLMEADAPVQELRELVTPLVKQAKCSRIASQAVHDLEAV 1199
+ +R + + V+ + V+++ + P + Q ++ A + + DL+ +
Sbjct: 253 EMVVKKGLAPEVADR-IGDYVQCHGGVSLVEQMFQ--DPRLSQ---NKQALEGLGDLKLL 306
Query: 1200 YRNAKALGCECPMTVAPLSAYNVTQHSGVFWQMSVVRSEQKSITKRRSGDLIAAGGRYDA 1259
+ G ++ A + ++GV ++ ++++ ++ + + +AAGGRYD
Sbjct: 307 FEYLTLFGIADKISFDLSLARGLDYYTGVIYEAVLLQTPTQAGEEPLNVGSVAAGGRYDG 366
Query: 1260 LVKEFWNVASAENDQDSADLNVCSVGFSMSLERMAAFLNKLETQTNVPIKSNET 1313
LV F D V VG S+ +ER+ + + +++ ET
Sbjct: 367 LVGMF----------DPKGHKVPCVGLSIGVERIFYIVEQRMKTKGEKVRTTET 410
>AL356423-1|CAI13113.1| 368|Homo sapiens serine/threonine kinase 24
(STE20 homolog, yeast) protein.
Length = 368
Score = 73.7 bits (173), Expect = 5e-12
Identities = 58/201 (28%), Positives = 96/201 (47%), Gaps = 20/201 (9%)
Query: 716 LYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLD 775
L+I ME+ + ++ G E A + REI++GL ++H IHRD+K N+ L
Sbjct: 12 LWIIMEYLGGGSALDLLEPGPLDETQIA-TILREILKGLDYLHSEKKIHRDIKAANVLLS 70
Query: 776 SNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQ 835
+ VK+ DFG+A G + + K+ +GT ++APE+++ + Y+
Sbjct: 71 EHGEVKLADFGVA-----GQLTDTQIKRNTF-------VGTPFWMAPEVIKQSA---YDS 115
Query: 836 KVDIYSLGIILFEMFH-PPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLL 894
K DI+SLGI E+ P + + M VL + + P + + + + L
Sbjct: 116 KADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNN---PPTLEGNYSKPLKEFVEACL 172
Query: 895 NHEASLRPTCAELLASEHVPR 915
N E S RPT ELL + + R
Sbjct: 173 NKEPSFRPTAKELLKHKFILR 193
Score = 37.5 bits (83), Expect = 0.38
Identities = 44/196 (22%), Positives = 88/196 (44%), Gaps = 37/196 (18%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
++I ++ G S +L++ G D ++ +LR + G L+ LH+ IHRD+++
Sbjct: 12 LWIIMEYLGGGSALDLLEP--GPLDETQIATILREILKG----LDYLHSEKKIHRDIKAA 65
Query: 396 NVFVDDVGQVKLVGASLDTRLAE-MLDNDNYCD----------KQT---PAQDIYATGQL 441
NV + + G+VKL + +L + + + + KQ+ DI++ G
Sbjct: 66 NVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGIT 125
Query: 442 LLSIVCKEKSYTE---------IPQELPCV--------AKDFISRCLTEDEHSQWSAKQL 484
+ + E ++E IP+ P K+F+ CL ++ + +AK+L
Sbjct: 126 AIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKEL 185
Query: 485 MSHYFLVEAPTKKPYV 500
+ H F++ K Y+
Sbjct: 186 LKHKFILRNAKKTSYL 201
>AL137249-2|CAI39452.1| 368|Homo sapiens serine/threonine kinase 24
(STE20 homolog, yeast) protein.
Length = 368
Score = 73.7 bits (173), Expect = 5e-12
Identities = 58/201 (28%), Positives = 96/201 (47%), Gaps = 20/201 (9%)
Query: 716 LYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLD 775
L+I ME+ + ++ G E A + REI++GL ++H IHRD+K N+ L
Sbjct: 12 LWIIMEYLGGGSALDLLEPGPLDETQIA-TILREILKGLDYLHSEKKIHRDIKAANVLLS 70
Query: 776 SNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQ 835
+ VK+ DFG+A G + + K+ +GT ++APE+++ + Y+
Sbjct: 71 EHGEVKLADFGVA-----GQLTDTQIKRNTF-------VGTPFWMAPEVIKQSA---YDS 115
Query: 836 KVDIYSLGIILFEMFH-PPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLL 894
K DI+SLGI E+ P + + M VL + + P + + + + L
Sbjct: 116 KADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNN---PPTLEGNYSKPLKEFVEACL 172
Query: 895 NHEASLRPTCAELLASEHVPR 915
N E S RPT ELL + + R
Sbjct: 173 NKEPSFRPTAKELLKHKFILR 193
Score = 37.5 bits (83), Expect = 0.38
Identities = 44/196 (22%), Positives = 88/196 (44%), Gaps = 37/196 (18%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
++I ++ G S +L++ G D ++ +LR + G L+ LH+ IHRD+++
Sbjct: 12 LWIIMEYLGGGSALDLLEP--GPLDETQIATILREILKG----LDYLHSEKKIHRDIKAA 65
Query: 396 NVFVDDVGQVKLVGASLDTRLAE-MLDNDNYCD----------KQT---PAQDIYATGQL 441
NV + + G+VKL + +L + + + + KQ+ DI++ G
Sbjct: 66 NVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGIT 125
Query: 442 LLSIVCKEKSYTE---------IPQELPCV--------AKDFISRCLTEDEHSQWSAKQL 484
+ + E ++E IP+ P K+F+ CL ++ + +AK+L
Sbjct: 126 AIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKEL 185
Query: 485 MSHYFLVEAPTKKPYV 500
+ H F++ K Y+
Sbjct: 186 LKHKFILRNAKKTSYL 201
>AF140507-1|AAD31507.1| 588|Homo sapiens Ca2+/calmodulin-dependent
protein kinase kinase beta protein.
Length = 588
Score = 73.7 bits (173), Expect = 5e-12
Identities = 38/142 (26%), Positives = 80/142 (56%), Gaps = 13/142 (9%)
Query: 747 FREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEI 806
F+++++G+ ++H + +IHRD+KP N+ + + H+KI DFG++ + F G
Sbjct: 293 FQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE-FKG-----------S 340
Query: 807 GGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVL-T 865
L+ +GT ++APE L K+ + D++++G+ L+ ER+M L +
Sbjct: 341 DALLSNYVGTPAFMAPESLSETRKIFSGKAKDVWAMGVTLYCFVFGQCPFMDERIMCLHS 400
Query: 866 NLRSKDIVIPNKFDVDENVKQI 887
++S+ + P++ D+ E++K +
Sbjct: 401 KIKSQALEFPDQPDIAEDLKDL 422
>U07349-1|AAA20968.1| 819|Homo sapiens GC kinase protein.
Length = 819
Score = 72.9 bits (171), Expect = 8e-12
Identities = 62/211 (29%), Positives = 102/211 (48%), Gaps = 24/211 (11%)
Query: 716 LYIQMEFCEKHTLRQAID-NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
L+I MEFC +L++ G +E A+ + RE ++GL H+H +G IHRD+K N+ L
Sbjct: 85 LWICMEFCGGGSLQEIYHATGPLEERQIAY-VCRERLKGLHHLHSQGKIHRDIKGANLLL 143
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
VK+ DFG+ +G K+ IGT ++APE+ K YN
Sbjct: 144 TLQGDVKLADFGV-----SGELTASVAKRRSF-------IGTPYWMAPEVAAVERKGGYN 191
Query: 835 QKVDIYSLGIILFEM--FHPPL--ETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVI 890
+ D+++LGI E+ PPL M +M+++ + + +K +N H +
Sbjct: 192 ELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFH--HFL 249
Query: 891 RWLLNHEASLRPTCAELL----ASEHVPRAV 917
+ L RPT +LL ++ +PRA+
Sbjct: 250 KLALTKNPKKRPTAEKLLQHPFTTQQLPRAL 280
Score = 42.3 bits (95), Expect = 0.013
Identities = 21/70 (30%), Positives = 38/70 (54%), Gaps = 2/70 (2%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENV 595
FE+L +G G +GDV K ++ + A+K V+L+P + +E+ +L H NV
Sbjct: 15 FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDD--ISSLQQEITILRECRHPNV 72
Query: 596 VRYYNAWIES 605
V Y +++ +
Sbjct: 73 VAYIGSYLRN 82
Score = 33.5 bits (73), Expect = 6.2
Identities = 35/149 (23%), Positives = 61/149 (40%), Gaps = 20/149 (13%)
Query: 259 SSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSNASLIPY 318
+ T Y A D T E K + P D ++S+QQ++ L + +++ Y
Sbjct: 23 AGTYGDVYKARDTVTSELAAVKIVKLDPGDD-------ISSLQQEITILRECRHPNVVAY 75
Query: 319 VAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSA 378
+ + N R ++I F G SL+ + + + +V L
Sbjct: 76 IGSYLR---NDR-----LWICMEFCGGGSLQEIYHATGPLEE-----RQIAYVCRERLKG 122
Query: 379 LNELHAANIIHRDVRSENVFVDDVGQVKL 407
L+ LH+ IHRD++ N+ + G VKL
Sbjct: 123 LHHLHSQGKIHRDIKGANLLLTLQGDVKL 151
>M60725-1|AAA36411.1| 502|Homo sapiens p70 ribosomal S6 kinase
alpha-II protein.
Length = 502
Score = 72.9 bits (171), Expect = 8e-12
Identities = 53/163 (32%), Positives = 83/163 (50%), Gaps = 20/163 (12%)
Query: 716 LYIQMEFCEKHTLRQAIDN-GLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
LY+ +E+ L ++ G+F E + L EI L H+HQ+G+I+RDLKP NI L
Sbjct: 145 LYLILEYLSGGELFMQLEREGIFMEDTACFYL-AEISMALGHLHQKGIIYRDLKPENIML 203
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
+ HVK+ DFGL ++ + D T GT Y+APE+L + +N
Sbjct: 204 NHQGHVKLTDFGLCKES-----IHDGTVTHTF-------CGTIEYMAPEILMRSG---HN 248
Query: 835 QKVDIYSLGIILFEMF--HPPLETGMERMMVLTNLRSKDIVIP 875
+ VD +SLG ++++M PP TG R + + + +P
Sbjct: 249 RAVDWWSLGALMYDMLTGAPPF-TGENRKKTIDKILKCKLNLP 290
Score = 33.9 bits (74), Expect = 4.7
Identities = 15/35 (42%), Positives = 21/35 (60%)
Query: 378 ALNELHAANIIHRDVRSENVFVDDVGQVKLVGASL 412
AL LH II+RD++ EN+ ++ G VKL L
Sbjct: 182 ALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGL 216
>M60724-1|AAA36410.1| 525|Homo sapiens p70 ribosomal S6 kinase
alpha-I protein.
Length = 525
Score = 72.9 bits (171), Expect = 8e-12
Identities = 53/163 (32%), Positives = 83/163 (50%), Gaps = 20/163 (12%)
Query: 716 LYIQMEFCEKHTLRQAIDN-GLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
LY+ +E+ L ++ G+F E + L EI L H+HQ+G+I+RDLKP NI L
Sbjct: 168 LYLILEYLSGGELFMQLEREGIFMEDTACFYL-AEISMALGHLHQKGIIYRDLKPENIML 226
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
+ HVK+ DFGL ++ + D T GT Y+APE+L + +N
Sbjct: 227 NHQGHVKLTDFGLCKES-----IHDGTVTHTF-------CGTIEYMAPEILMRSG---HN 271
Query: 835 QKVDIYSLGIILFEMF--HPPLETGMERMMVLTNLRSKDIVIP 875
+ VD +SLG ++++M PP TG R + + + +P
Sbjct: 272 RAVDWWSLGALMYDMLTGAPPF-TGENRKKTIDKILKCKLNLP 313
Score = 33.9 bits (74), Expect = 4.7
Identities = 15/35 (42%), Positives = 21/35 (60%)
Query: 378 ALNELHAANIIHRDVRSENVFVDDVGQVKLVGASL 412
AL LH II+RD++ EN+ ++ G VKL L
Sbjct: 205 ALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGL 239
>BC053365-1|AAH53365.1| 451|Homo sapiens RPS6KB1 protein protein.
Length = 451
Score = 72.9 bits (171), Expect = 8e-12
Identities = 53/163 (32%), Positives = 83/163 (50%), Gaps = 20/163 (12%)
Query: 716 LYIQMEFCEKHTLRQAIDN-GLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFL 774
LY+ +E+ L ++ G+F E + L EI L H+HQ+G+I+RDLKP NI L
Sbjct: 168 LYLILEYLSGGELFMQLEREGIFMEDTACFYL-AEISMALGHLHQKGIIYRDLKPENIML 226
Query: 775 DSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYN 834
+ HVK+ DFGL ++ + D T GT Y+APE+L + +N
Sbjct: 227 NHQGHVKLTDFGLCKES-----IHDGTVTHTF-------CGTIEYMAPEILMRSG---HN 271
Query: 835 QKVDIYSLGIILFEMF--HPPLETGMERMMVLTNLRSKDIVIP 875
+ VD +SLG ++++M PP TG R + + + +P
Sbjct: 272 RAVDWWSLGALMYDMLTGAPPF-TGENRKKTIDKILKCKLNLP 313
Score = 33.9 bits (74), Expect = 4.7
Identities = 15/35 (42%), Positives = 21/35 (60%)
Query: 378 ALNELHAANIIHRDVRSENVFVDDVGQVKLVGASL 412
AL LH II+RD++ EN+ ++ G VKL L
Sbjct: 205 ALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGL 239
>U56998-1|AAC50637.1| 607|Homo sapiens putative serine/threonine
protein kinase PRK protein.
Length = 607
Score = 72.5 bits (170), Expect = 1e-11
Identities = 49/145 (33%), Positives = 77/145 (53%), Gaps = 21/145 (14%)
Query: 716 LYIQMEFCEKHTLRQA--IDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIF 773
+YI +E C + +L + L + R + R+I+ GL ++HQRG++HRDLK N F
Sbjct: 96 IYIFLELCSRKSLAHIWKARHTLLEPEVRYY--LRQILSGLKYLHQRGILHRDLKLGNFF 153
Query: 774 LDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIY 833
+ N +K+GDFGLA + P E + K GT YVAPE+L + +
Sbjct: 154 ITENMELKVGDFGLAARL---EPPEQRKKT---------ICGTPNYVAPEVL---LRQGH 198
Query: 834 NQKVDIYSLGIILFEMF--HPPLET 856
+ D++SLG +++ + PP ET
Sbjct: 199 GPEADVWSLGCVMYTLLCGSPPFET 223
Score = 33.1 bits (72), Expect = 8.1
Identities = 16/49 (32%), Positives = 27/49 (55%)
Query: 368 LRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRL 416
+R+ +LS L LH I+HRD++ N F+ + ++K+ L RL
Sbjct: 123 VRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARL 171
>BC013899-1|AAH13899.1| 646|Homo sapiens polo-like kinase 3
(Drosophila) protein.
Length = 646
Score = 72.5 bits (170), Expect = 1e-11
Identities = 49/145 (33%), Positives = 77/145 (53%), Gaps = 21/145 (14%)
Query: 716 LYIQMEFCEKHTLRQA--IDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIF 773
+YI +E C + +L + L + R + R+I+ GL ++HQRG++HRDLK N F
Sbjct: 135 IYIFLELCSRKSLAHIWKARHTLLEPEVRYY--LRQILSGLKYLHQRGILHRDLKLGNFF 192
Query: 774 LDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIY 833
+ N +K+GDFGLA + P E + K GT YVAPE+L + +
Sbjct: 193 ITENMELKVGDFGLAARL---EPPEQRKKT---------ICGTPNYVAPEVL---LRQGH 237
Query: 834 NQKVDIYSLGIILFEMF--HPPLET 856
+ D++SLG +++ + PP ET
Sbjct: 238 GPEADVWSLGCVMYTLLCGSPPFET 262
Score = 33.1 bits (72), Expect = 8.1
Identities = 16/49 (32%), Positives = 27/49 (55%)
Query: 368 LRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRL 416
+R+ +LS L LH I+HRD++ N F+ + ++K+ L RL
Sbjct: 162 VRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARL 210
>AY764184-1|AAU88146.1| 646|Homo sapiens polo-like kinase 3
(Drosophila) protein.
Length = 646
Score = 72.5 bits (170), Expect = 1e-11
Identities = 49/145 (33%), Positives = 77/145 (53%), Gaps = 21/145 (14%)
Query: 716 LYIQMEFCEKHTLRQA--IDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIF 773
+YI +E C + +L + L + R + R+I+ GL ++HQRG++HRDLK N F
Sbjct: 135 IYIFLELCSRKSLAHIWKARHTLLEPEVRYY--LRQILSGLKYLHQRGILHRDLKLGNFF 192
Query: 774 LDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIY 833
+ N +K+GDFGLA + P E + K GT YVAPE+L + +
Sbjct: 193 ITENMELKVGDFGLAARL---EPPEQRKKT---------ICGTPNYVAPEVL---LRQGH 237
Query: 834 NQKVDIYSLGIILFEMF--HPPLET 856
+ D++SLG +++ + PP ET
Sbjct: 238 GPEADVWSLGCVMYTLLCGSPPFET 262
Score = 33.1 bits (72), Expect = 8.1
Identities = 16/49 (32%), Positives = 27/49 (55%)
Query: 368 LRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRL 416
+R+ +LS L LH I+HRD++ N F+ + ++K+ L RL
Sbjct: 162 VRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARL 210
>AL592166-11|CAI13006.1| 646|Homo sapiens polo-like kinase 3
(Drosophila) protein.
Length = 646
Score = 72.5 bits (170), Expect = 1e-11
Identities = 49/145 (33%), Positives = 77/145 (53%), Gaps = 21/145 (14%)
Query: 716 LYIQMEFCEKHTLRQA--IDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIF 773
+YI +E C + +L + L + R + R+I+ GL ++HQRG++HRDLK N F
Sbjct: 135 IYIFLELCSRKSLAHIWKARHTLLEPEVRYY--LRQILSGLKYLHQRGILHRDLKLGNFF 192
Query: 774 LDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIY 833
+ N +K+GDFGLA + P E + K GT YVAPE+L + +
Sbjct: 193 ITENMELKVGDFGLAARL---EPPEQRKKT---------ICGTPNYVAPEVL---LRQGH 237
Query: 834 NQKVDIYSLGIILFEMF--HPPLET 856
+ D++SLG +++ + PP ET
Sbjct: 238 GPEADVWSLGCVMYTLLCGSPPFET 262
Score = 33.1 bits (72), Expect = 8.1
Identities = 16/49 (32%), Positives = 27/49 (55%)
Query: 368 LRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRL 416
+R+ +LS L LH I+HRD++ N F+ + ++K+ L RL
Sbjct: 162 VRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARL 210
>AJ293866-1|CAC10659.1| 646|Homo sapiens FNK serine/threonine
protein kinase protein.
Length = 646
Score = 72.5 bits (170), Expect = 1e-11
Identities = 49/145 (33%), Positives = 77/145 (53%), Gaps = 21/145 (14%)
Query: 716 LYIQMEFCEKHTLRQA--IDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIF 773
+YI +E C + +L + L + R + R+I+ GL ++HQRG++HRDLK N F
Sbjct: 135 IYIFLELCSRKSLAHIWKARHTLLEPEVRYY--LRQILSGLKYLHQRGILHRDLKLGNFF 192
Query: 774 LDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIY 833
+ N +K+GDFGLA + P E + K GT YVAPE+L + +
Sbjct: 193 ITENMELKVGDFGLAARL---EPPEQRKKT---------ICGTPNYVAPEVL---LRQGH 237
Query: 834 NQKVDIYSLGIILFEMF--HPPLET 856
+ D++SLG +++ + PP ET
Sbjct: 238 GPEADVWSLGCVMYTLLCGSPPFET 262
Score = 33.1 bits (72), Expect = 8.1
Identities = 16/49 (32%), Positives = 27/49 (55%)
Query: 368 LRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRL 416
+R+ +LS L LH I+HRD++ N F+ + ++K+ L RL
Sbjct: 162 VRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARL 210
>AB209875-1|BAD93112.1| 621|Homo sapiens polo-like kinase 3 variant
protein.
Length = 621
Score = 72.5 bits (170), Expect = 1e-11
Identities = 49/145 (33%), Positives = 77/145 (53%), Gaps = 21/145 (14%)
Query: 716 LYIQMEFCEKHTLRQA--IDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIF 773
+YI +E C + +L + L + R + R+I+ GL ++HQRG++HRDLK N F
Sbjct: 110 IYIFLELCSRKSLAHIWKARHTLLEPEVRYY--LRQILSGLKYLHQRGILHRDLKLGNFF 167
Query: 774 LDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIY 833
+ N +K+GDFGLA + P E + K GT YVAPE+L + +
Sbjct: 168 ITENMELKVGDFGLAARL---EPPEQRKKT---------ICGTPNYVAPEVL---LRQGH 212
Query: 834 NQKVDIYSLGIILFEMF--HPPLET 856
+ D++SLG +++ + PP ET
Sbjct: 213 GPEADVWSLGCVMYTLLCGSPPFET 237
Score = 33.1 bits (72), Expect = 8.1
Identities = 16/49 (32%), Positives = 27/49 (55%)
Query: 368 LRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRL 416
+R+ +LS L LH I+HRD++ N F+ + ++K+ L RL
Sbjct: 137 VRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARL 185
>X99325-1|CAA67700.1| 426|Homo sapiens Ste20-like kinase protein.
Length = 426
Score = 72.1 bits (169), Expect = 1e-11
Identities = 66/243 (27%), Positives = 110/243 (45%), Gaps = 26/243 (10%)
Query: 680 ELIEFEKTSDDEES--QTLPSEDVVDAP---RPQSERLKQV-LYIQMEFCEKHTLRQAID 733
++I+ E+ D+ E Q + D+P R LK L+I ME+ + +
Sbjct: 49 KIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK 108
Query: 734 NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFT 793
G +E + A + REI++GL ++H IHRD+K N+ L VK+ DFG+A
Sbjct: 109 PGPLEETYIA-TILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVA----- 162
Query: 794 GLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH-P 852
G + + K+ +GT ++APE+++ + Y+ K DI+SLGI E+
Sbjct: 163 GQLTDTQIKRNTF-------VGTPFWMAPEVIKQSA---YDFKADIWSLGITAIELAKGE 212
Query: 853 PLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEH 912
P + + M VL + P + + + LN + RPT ELL +
Sbjct: 213 PPNSDLHPMRVLFLIPKNS---PPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKF 269
Query: 913 VPR 915
+ R
Sbjct: 270 ITR 272
Score = 41.9 bits (94), Expect = 0.018
Identities = 28/85 (32%), Positives = 48/85 (56%), Gaps = 4/85 (4%)
Query: 524 FANNGLSRLDAE--FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKIT 581
FAN SR+D E F L +GKG+FG+V K + AIK + L ++ + I
Sbjct: 7 FANQH-SRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEI-EDIQ 64
Query: 582 REVKLLSRLNHENVVRYYNAWIEST 606
+E+ +LS+ + + RY+ ++++ST
Sbjct: 65 QEITVLSQCDSPYITRYFGSYLKST 89
Score = 39.1 bits (87), Expect = 0.12
Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 21/163 (12%)
Query: 256 LGHSSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSNASL 315
+G S G Y ID+ T E + K + A D ++ IQQ++ L++ + +
Sbjct: 26 IGKGSFGEV-YKGIDNHTKEVVAIKIIDLEEAED------EIEDIQQEITVLSQCDSPYI 78
Query: 316 IPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGV 375
Y + +++K ++I ++ G S +L+K G + + +LR + G
Sbjct: 79 TRYFGSYL------KSTK--LWIIMEYLGGGSALDLLKP--GPLEETYIATILREILKG- 127
Query: 376 LSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAE 418
L+ LH+ IHRD+++ NV + + G VKL + +L +
Sbjct: 128 ---LDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTD 167
>D63780-1|BAA20420.1| 426|Homo sapiens YSK1 protein.
Length = 426
Score = 72.1 bits (169), Expect = 1e-11
Identities = 66/243 (27%), Positives = 110/243 (45%), Gaps = 26/243 (10%)
Query: 680 ELIEFEKTSDDEES--QTLPSEDVVDAP---RPQSERLKQV-LYIQMEFCEKHTLRQAID 733
++I+ E+ D+ E Q + D+P R LK L+I ME+ + +
Sbjct: 49 KIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK 108
Query: 734 NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFT 793
G +E + A + REI++GL ++H IHRD+K N+ L VK+ DFG+A
Sbjct: 109 PGPLEETYIA-TILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVA----- 162
Query: 794 GLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH-P 852
G + + K+ +GT ++APE+++ + Y+ K DI+SLGI E+
Sbjct: 163 GQLTDTQIKRNTF-------VGTPFWMAPEVIKQSA---YDFKADIWSLGITAIELAKGE 212
Query: 853 PLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEH 912
P + + M VL + P + + + LN + RPT ELL +
Sbjct: 213 PPNSDLHPMRVLFLIPKNS---PPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKF 269
Query: 913 VPR 915
+ R
Sbjct: 270 ITR 272
Score = 41.9 bits (94), Expect = 0.018
Identities = 28/85 (32%), Positives = 48/85 (56%), Gaps = 4/85 (4%)
Query: 524 FANNGLSRLDAE--FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKIT 581
FAN SR+D E F L +GKG+FG+V K + AIK + L ++ + I
Sbjct: 7 FANQH-SRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEI-EDIQ 64
Query: 582 REVKLLSRLNHENVVRYYNAWIEST 606
+E+ +LS+ + + RY+ ++++ST
Sbjct: 65 QEITVLSQCDSPYITRYFGSYLKST 89
Score = 39.1 bits (87), Expect = 0.12
Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 21/163 (12%)
Query: 256 LGHSSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSNASL 315
+G S G Y ID+ T E + K + A D ++ IQQ++ L++ + +
Sbjct: 26 IGKGSFGEV-YKGIDNHTKEVVAIKIIDLEEAED------EIEDIQQEITVLSQCDSPYI 78
Query: 316 IPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGV 375
Y + +++K ++I ++ G S +L+K G + + +LR + G
Sbjct: 79 TRYFGSYL------KSTK--LWIIMEYLGGGSALDLLKP--GPLEETYIATILREILKG- 127
Query: 376 LSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAE 418
L+ LH+ IHRD+++ NV + + G VKL + +L +
Sbjct: 128 ---LDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTD 167
>DQ093965-1|AAY88740.1| 426|Homo sapiens serine/threonine kinase 25
(STE20 homolog, yeast) protein.
Length = 426
Score = 72.1 bits (169), Expect = 1e-11
Identities = 66/243 (27%), Positives = 110/243 (45%), Gaps = 26/243 (10%)
Query: 680 ELIEFEKTSDDEES--QTLPSEDVVDAP---RPQSERLKQV-LYIQMEFCEKHTLRQAID 733
++I+ E+ D+ E Q + D+P R LK L+I ME+ + +
Sbjct: 49 KIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK 108
Query: 734 NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFT 793
G +E + A + REI++GL ++H IHRD+K N+ L VK+ DFG+A
Sbjct: 109 PGPLEETYIA-TILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVA----- 162
Query: 794 GLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH-P 852
G + + K+ +GT ++APE+++ + Y+ K DI+SLGI E+
Sbjct: 163 GQLTDTQIKRNTF-------VGTPFWMAPEVIKQSA---YDFKADIWSLGITAIELAKGE 212
Query: 853 PLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEH 912
P + + M VL + P + + + LN + RPT ELL +
Sbjct: 213 PPNSDLHPMRVLFLIPKNS---PPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKF 269
Query: 913 VPR 915
+ R
Sbjct: 270 ITR 272
Score = 41.9 bits (94), Expect = 0.018
Identities = 28/85 (32%), Positives = 48/85 (56%), Gaps = 4/85 (4%)
Query: 524 FANNGLSRLDAE--FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKIT 581
FAN SR+D E F L +GKG+FG+V K + AIK + L ++ + I
Sbjct: 7 FANQH-SRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEI-EDIQ 64
Query: 582 REVKLLSRLNHENVVRYYNAWIEST 606
+E+ +LS+ + + RY+ ++++ST
Sbjct: 65 QEITVLSQCDSPYITRYFGSYLKST 89
Score = 39.1 bits (87), Expect = 0.12
Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 21/163 (12%)
Query: 256 LGHSSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSNASL 315
+G S G Y ID+ T E + K + A D ++ IQQ++ L++ + +
Sbjct: 26 IGKGSFGEV-YKGIDNHTKEVVAIKIIDLEEAED------EIEDIQQEITVLSQCDSPYI 78
Query: 316 IPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGV 375
Y + +++K ++I ++ G S +L+K G + + +LR + G
Sbjct: 79 TRYFGSYL------KSTK--LWIIMEYLGGGSALDLLKP--GPLEETYIATILREILKG- 127
Query: 376 LSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAE 418
L+ LH+ IHRD+++ NV + + G VKL + +L +
Sbjct: 128 ---LDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTD 167
>CR542227-1|CAG47023.1| 431|Homo sapiens STK24 protein.
Length = 431
Score = 72.1 bits (169), Expect = 1e-11
Identities = 66/243 (27%), Positives = 112/243 (46%), Gaps = 26/243 (10%)
Query: 680 ELIEFEKTSDDEES--QTLPSEDVVDAP---RPQSERLKQV-LYIQMEFCEKHTLRQAID 733
++I+ E+ D+ E Q + D+P + LK L+I ME+ + ++
Sbjct: 53 KIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE 112
Query: 734 NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFT 793
G E A + REI++GL ++H IHRD+K N+ L + VK+ D G+A
Sbjct: 113 PGPLDETQIA-TILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADIGVA----- 166
Query: 794 GLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH-P 852
G + + K+ +GT ++APE+++ + Y+ K DI+SLGI E+
Sbjct: 167 GQLTDTQIKRNTF-------VGTPFWMAPEVIKQSA---YDSKADIWSLGITAIELARGE 216
Query: 853 PLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEH 912
P + + M VL + + P + + + + LN E S RPT ELL +
Sbjct: 217 PPHSELHPMKVLFLIPKNN---PPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKF 273
Query: 913 VPR 915
+ R
Sbjct: 274 ILR 276
Score = 41.1 bits (92), Expect = 0.031
Identities = 53/243 (21%), Positives = 105/243 (43%), Gaps = 45/243 (18%)
Query: 289 DFQTRNKQLTSIQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSL 348
D + ++ IQQ++ L++ + PYV K ++I ++ G S
Sbjct: 56 DLEEAEDEIEDIQQEITVLSQCDS----PYVT----KYYGSYLKDTKLWIIMEYLGGGSA 107
Query: 349 KNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLV 408
+L++ G D ++ +LR + G L+ LH+ IHRD+++ NV + + G+VKL
Sbjct: 108 LDLLEP--GPLDETQIATILREILKG----LDYLHSEKKIHRDIKAANVLLSEHGEVKLA 161
Query: 409 GASLDTRLAE-MLDNDNYCD----------KQT---PAQDIYATGQLLLSIVCKEKSYTE 454
+ +L + + + + KQ+ DI++ G + + E ++E
Sbjct: 162 DIGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSE 221
Query: 455 ---------IPQELPCV--------AKDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTKK 497
IP+ P K+F+ CL ++ + +AK+L+ H F++ K
Sbjct: 222 LHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKT 281
Query: 498 PYV 500
Y+
Sbjct: 282 SYL 284
Score = 38.3 bits (85), Expect = 0.22
Identities = 21/71 (29%), Positives = 39/71 (54%), Gaps = 1/71 (1%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENV 595
F L +GKG+FG+V K + AIK + L ++ + I +E+ +LS+ + V
Sbjct: 24 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEI-EDIQQEITVLSQCDSPYV 82
Query: 596 VRYYNAWIEST 606
+YY ++++ T
Sbjct: 83 TKYYGSYLKDT 93
>BT019961-1|AAV38764.1| 426|Homo sapiens serine/threonine kinase 25
(STE20 homolog, yeast) protein.
Length = 426
Score = 72.1 bits (169), Expect = 1e-11
Identities = 66/243 (27%), Positives = 110/243 (45%), Gaps = 26/243 (10%)
Query: 680 ELIEFEKTSDDEES--QTLPSEDVVDAP---RPQSERLKQV-LYIQMEFCEKHTLRQAID 733
++I+ E+ D+ E Q + D+P R LK L+I ME+ + +
Sbjct: 49 KIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK 108
Query: 734 NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFT 793
G +E + A + REI++GL ++H IHRD+K N+ L VK+ DFG+A
Sbjct: 109 PGPLEETYIA-TILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVA----- 162
Query: 794 GLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH-P 852
G + + K+ +GT ++APE+++ + Y+ K DI+SLGI E+
Sbjct: 163 GQLTDTQIKRNTF-------VGTPFWMAPEVIKQSA---YDFKADIWSLGITAIELAKGE 212
Query: 853 PLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEH 912
P + + M VL + P + + + LN + RPT ELL +
Sbjct: 213 PPNSDLHPMRVLFLIPKNS---PPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKF 269
Query: 913 VPR 915
+ R
Sbjct: 270 ITR 272
Score = 41.9 bits (94), Expect = 0.018
Identities = 28/85 (32%), Positives = 48/85 (56%), Gaps = 4/85 (4%)
Query: 524 FANNGLSRLDAE--FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKIT 581
FAN SR+D E F L +GKG+FG+V K + AIK + L ++ + I
Sbjct: 7 FANQH-SRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEI-EDIQ 64
Query: 582 REVKLLSRLNHENVVRYYNAWIEST 606
+E+ +LS+ + + RY+ ++++ST
Sbjct: 65 QEITVLSQCDSPYITRYFGSYLKST 89
Score = 39.1 bits (87), Expect = 0.12
Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 21/163 (12%)
Query: 256 LGHSSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSNASL 315
+G S G Y ID+ T E + K + A D ++ IQQ++ L++ + +
Sbjct: 26 IGKGSFGEV-YKGIDNHTKEVVAIKIIDLEEAED------EIEDIQQEITVLSQCDSPYI 78
Query: 316 IPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGV 375
Y + +++K ++I ++ G S +L+K G + + +LR + G
Sbjct: 79 TRYFGSYL------KSTK--LWIIMEYLGGGSALDLLKP--GPLEETYIATILREILKG- 127
Query: 376 LSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAE 418
L+ LH+ IHRD+++ NV + + G VKL + +L +
Sbjct: 128 ---LDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTD 167
>BC114491-1|AAI14492.1| 1189|Homo sapiens NEK1 protein protein.
Length = 1189
Score = 72.1 bits (169), Expect = 1e-11
Identities = 56/155 (36%), Positives = 83/155 (53%), Gaps = 23/155 (14%)
Query: 716 LYIQMEFCEKHTLRQAID---NGLFQE-HFRAWRLFREIVEGLAHVHQRGMIHRDLKPVN 771
LYI M++CE L + I+ LFQE W F +I L HVH R ++HRD+K N
Sbjct: 76 LYIVMDYCEGGDLFKRINAQKGVLFQEDQILDW--FVQICLALKHVHDRKILHRDIKSQN 133
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
IFL + V++GDFG+A V + T E+ + IGT Y++PE+ ++
Sbjct: 134 IFLTKDGTVQLGDFGIAR-------VLNST--VELARTC---IGTPYYLSPEICENKP-- 179
Query: 832 IYNQKVDIYSLGIILFEM--FHPPLETGMERMMVL 864
YN K DI++LG +L+E+ E G + +VL
Sbjct: 180 -YNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVL 213
Score = 48.0 bits (109), Expect = 3e-04
Identities = 21/64 (32%), Positives = 40/64 (62%)
Query: 542 LGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENVVRYYNA 601
+G+G+FG + VK+ DG Y IK + ++ S + ++ REV +L+ + H N+V+Y +
Sbjct: 10 IGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQYRES 69
Query: 602 WIES 605
+ E+
Sbjct: 70 FEEN 73
Score = 34.3 bits (75), Expect = 3.5
Identities = 13/30 (43%), Positives = 21/30 (70%)
Query: 378 ALNELHAANIIHRDVRSENVFVDDVGQVKL 407
AL +H I+HRD++S+N+F+ G V+L
Sbjct: 115 ALKHVHDRKILHRDIKSQNIFLTKDGTVQL 144
>BC091505-1|AAH91505.1| 426|Homo sapiens STK25 protein protein.
Length = 426
Score = 72.1 bits (169), Expect = 1e-11
Identities = 66/243 (27%), Positives = 110/243 (45%), Gaps = 26/243 (10%)
Query: 680 ELIEFEKTSDDEES--QTLPSEDVVDAP---RPQSERLKQV-LYIQMEFCEKHTLRQAID 733
++I+ E+ D+ E Q + D+P R LK L+I ME+ + +
Sbjct: 49 KIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK 108
Query: 734 NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFT 793
G +E + A + REI++GL ++H IHRD+K N+ L VK+ DFG+A
Sbjct: 109 PGPLEETYIA-TILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVA----- 162
Query: 794 GLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH-P 852
G + + K+ +GT ++APE+++ + Y+ K DI+SLGI E+
Sbjct: 163 GQLTDTQIKRNTF-------VGTPFWMAPEVIKQSA---YDFKADIWSLGITAIELAKGE 212
Query: 853 PLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEH 912
P + + M VL + P + + + LN + RPT ELL +
Sbjct: 213 PPNSDLHPMRVLFLIPKNS---PPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKF 269
Query: 913 VPR 915
+ R
Sbjct: 270 ITR 272
Score = 41.9 bits (94), Expect = 0.018
Identities = 28/85 (32%), Positives = 48/85 (56%), Gaps = 4/85 (4%)
Query: 524 FANNGLSRLDAE--FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKIT 581
FAN SR+D E F L +GKG+FG+V K + AIK + L ++ + I
Sbjct: 7 FANQH-SRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEI-EDIQ 64
Query: 582 REVKLLSRLNHENVVRYYNAWIEST 606
+E+ +LS+ + + RY+ ++++ST
Sbjct: 65 QEITVLSQCDSPYITRYFGSYLKST 89
Score = 39.1 bits (87), Expect = 0.12
Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 21/163 (12%)
Query: 256 LGHSSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSNASL 315
+G S G Y ID+ T E + K + A D ++ IQQ++ L++ + +
Sbjct: 26 IGKGSFGEV-YKGIDNHTKEVVAIKIIDLEEAED------EIEDIQQEITVLSQCDSPYI 78
Query: 316 IPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGV 375
Y + +++K ++I ++ G S +L+K G + + +LR + G
Sbjct: 79 TRYFGSYL------KSTK--LWIIMEYLGGGSALDLLKP--GPLEETYIATILREILKG- 127
Query: 376 LSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAE 418
L+ LH+ IHRD+++ NV + + G VKL + +L +
Sbjct: 128 ---LDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTD 167
>BC015793-1|AAH15793.1| 426|Homo sapiens STK25 protein protein.
Length = 426
Score = 72.1 bits (169), Expect = 1e-11
Identities = 66/243 (27%), Positives = 110/243 (45%), Gaps = 26/243 (10%)
Query: 680 ELIEFEKTSDDEES--QTLPSEDVVDAP---RPQSERLKQV-LYIQMEFCEKHTLRQAID 733
++I+ E+ D+ E Q + D+P R LK L+I ME+ + +
Sbjct: 49 KIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK 108
Query: 734 NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFT 793
G +E + A + REI++GL ++H IHRD+K N+ L VK+ DFG+A
Sbjct: 109 PGPLEETYIA-TILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVA----- 162
Query: 794 GLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH-P 852
G + + K+ +GT ++APE+++ + Y+ K DI+SLGI E+
Sbjct: 163 GQLTDTQIKRNTF-------VGTPFWMAPEVIKQSA---YDFKADIWSLGITAIELAKGE 212
Query: 853 PLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEH 912
P + + M VL + P + + + LN + RPT ELL +
Sbjct: 213 PPNSDLHPMRVLFLIPKNS---PPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKF 269
Query: 913 VPR 915
+ R
Sbjct: 270 ITR 272
Score = 41.9 bits (94), Expect = 0.018
Identities = 28/85 (32%), Positives = 48/85 (56%), Gaps = 4/85 (4%)
Query: 524 FANNGLSRLDAE--FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKIT 581
FAN SR+D E F L +GKG+FG+V K + AIK + L ++ + I
Sbjct: 7 FANQH-SRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEI-EDIQ 64
Query: 582 REVKLLSRLNHENVVRYYNAWIEST 606
+E+ +LS+ + + RY+ ++++ST
Sbjct: 65 QEITVLSQCDSPYITRYFGSYLKST 89
Score = 39.1 bits (87), Expect = 0.12
Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 21/163 (12%)
Query: 256 LGHSSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSNASL 315
+G S G Y ID+ T E + K + A D ++ IQQ++ L++ + +
Sbjct: 26 IGKGSFGEV-YKGIDNHTKEVVAIKIIDLEEAED------EIEDIQQEITVLSQCDSPYI 78
Query: 316 IPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGV 375
Y + +++K ++I ++ G S +L+K G + + +LR + G
Sbjct: 79 TRYFGSYL------KSTK--LWIIMEYLGGGSALDLLKP--GPLEETYIATILREILKG- 127
Query: 376 LSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAE 418
L+ LH+ IHRD+++ NV + + G VKL + +L +
Sbjct: 128 ---LDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTD 167
>BC015147-1|AAH15147.1| 403|Homo sapiens Unknown (protein for
IMAGE:4063881) protein.
Length = 403
Score = 72.1 bits (169), Expect = 1e-11
Identities = 56/155 (36%), Positives = 83/155 (53%), Gaps = 23/155 (14%)
Query: 716 LYIQMEFCEKHTLRQAID---NGLFQE-HFRAWRLFREIVEGLAHVHQRGMIHRDLKPVN 771
LYI M++CE L + I+ LFQE W F +I L HVH R ++HRD+K N
Sbjct: 76 LYIVMDYCEGGDLFKRINAQKGVLFQEDQILDW--FVQICLALKHVHDRKILHRDIKSQN 133
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
IFL + V++GDFG+A V + T E+ + IGT Y++PE+ ++
Sbjct: 134 IFLTKDGTVQLGDFGIAR-------VLNST--VELARTC---IGTPYYLSPEICENKP-- 179
Query: 832 IYNQKVDIYSLGIILFEM--FHPPLETGMERMMVL 864
YN K DI++LG +L+E+ E G + +VL
Sbjct: 180 -YNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVL 213
Score = 48.0 bits (109), Expect = 3e-04
Identities = 21/64 (32%), Positives = 40/64 (62%)
Query: 542 LGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENVVRYYNA 601
+G+G+FG + VK+ DG Y IK + ++ S + ++ REV +L+ + H N+V+Y +
Sbjct: 10 IGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQYRES 69
Query: 602 WIES 605
+ E+
Sbjct: 70 FEEN 73
Score = 34.3 bits (75), Expect = 3.5
Identities = 13/30 (43%), Positives = 21/30 (70%)
Query: 378 ALNELHAANIIHRDVRSENVFVDDVGQVKL 407
AL +H I+HRD++S+N+F+ G V+L
Sbjct: 115 ALKHVHDRKILHRDIKSQNIFLTKDGTVQL 144
>BC007852-1|AAH07852.1| 426|Homo sapiens serine/threonine kinase 25
(STE20 homolog, yeast) protein.
Length = 426
Score = 72.1 bits (169), Expect = 1e-11
Identities = 66/243 (27%), Positives = 110/243 (45%), Gaps = 26/243 (10%)
Query: 680 ELIEFEKTSDDEES--QTLPSEDVVDAP---RPQSERLKQV-LYIQMEFCEKHTLRQAID 733
++I+ E+ D+ E Q + D+P R LK L+I ME+ + +
Sbjct: 49 KIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK 108
Query: 734 NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFT 793
G +E + A + REI++GL ++H IHRD+K N+ L VK+ DFG+A
Sbjct: 109 PGPLEETYIA-TILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVA----- 162
Query: 794 GLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH-P 852
G + + K+ +GT ++APE+++ + Y+ K DI+SLGI E+
Sbjct: 163 GQLTDTQIKRNTF-------VGTPFWMAPEVIKQSA---YDFKADIWSLGITAIELAKGE 212
Query: 853 PLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEH 912
P + + M VL + P + + + LN + RPT ELL +
Sbjct: 213 PPNSDLHPMRVLFLIPKNS---PPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKF 269
Query: 913 VPR 915
+ R
Sbjct: 270 ITR 272
Score = 41.9 bits (94), Expect = 0.018
Identities = 28/85 (32%), Positives = 48/85 (56%), Gaps = 4/85 (4%)
Query: 524 FANNGLSRLDAE--FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKIT 581
FAN SR+D E F L +GKG+FG+V K + AIK + L ++ + I
Sbjct: 7 FANQH-SRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEI-EDIQ 64
Query: 582 REVKLLSRLNHENVVRYYNAWIEST 606
+E+ +LS+ + + RY+ ++++ST
Sbjct: 65 QEITVLSQCDSPYITRYFGSYLKST 89
Score = 39.1 bits (87), Expect = 0.12
Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 21/163 (12%)
Query: 256 LGHSSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSNASL 315
+G S G Y ID+ T E + K + A D ++ IQQ++ L++ + +
Sbjct: 26 IGKGSFGEV-YKGIDNHTKEVVAIKIIDLEEAED------EIEDIQQEITVLSQCDSPYI 78
Query: 316 IPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGV 375
Y + +++K ++I ++ G S +L+K G + + +LR + G
Sbjct: 79 TRYFGSYL------KSTK--LWIIMEYLGGGSALDLLKP--GPLEETYIATILREILKG- 127
Query: 376 LSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAE 418
L+ LH+ IHRD+++ NV + + G VKL + +L +
Sbjct: 128 ---LDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTD 167
>AF030403-1|AAD01901.1| 547|Homo sapiens Ste20-like protein kinase
protein.
Length = 547
Score = 72.1 bits (169), Expect = 1e-11
Identities = 54/190 (28%), Positives = 93/190 (48%), Gaps = 17/190 (8%)
Query: 734 NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFT 793
NG+ +E A +F+E++EGL ++H+ G IHRDLK NI L + V+I DFG++ T
Sbjct: 163 NGVLEEAIIA-TIFKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLAT 221
Query: 794 GLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMF--H 851
G V ++ +GT ++APE+++ Y+ K D++S GI E+
Sbjct: 222 GGDVTRNKVRKTF-------VGTPCWMAPEVMEQVRG--YDFKADMWSFGITAIELATGA 272
Query: 852 PPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQI-----HVIRWLLNHEASLRPTCAE 906
P +++ L++ + + E +K+ ++ L + S RPT AE
Sbjct: 273 APYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAE 332
Query: 907 LLASEHVPRA 916
LL + +A
Sbjct: 333 LLKCKFFQKA 342
Score = 33.9 bits (74), Expect = 4.7
Identities = 19/68 (27%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENV 595
+E+ +G GA V K AIKR+ L +++ + +E++ +S+ +H NV
Sbjct: 65 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDE-LLKEIQAMSQCSHPNV 123
Query: 596 VRYYNAWI 603
V YY +++
Sbjct: 124 VTYYTSFV 131
>AC110299-2|AAY14683.1| 426|Homo sapiens unknown protein.
Length = 426
Score = 72.1 bits (169), Expect = 1e-11
Identities = 66/243 (27%), Positives = 110/243 (45%), Gaps = 26/243 (10%)
Query: 680 ELIEFEKTSDDEES--QTLPSEDVVDAP---RPQSERLKQV-LYIQMEFCEKHTLRQAID 733
++I+ E+ D+ E Q + D+P R LK L+I ME+ + +
Sbjct: 49 KIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK 108
Query: 734 NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFT 793
G +E + A + REI++GL ++H IHRD+K N+ L VK+ DFG+A
Sbjct: 109 PGPLEETYIA-TILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVA----- 162
Query: 794 GLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH-P 852
G + + K+ +GT ++APE+++ + Y+ K DI+SLGI E+
Sbjct: 163 GQLTDTQIKRNTF-------VGTPFWMAPEVIKQSA---YDFKADIWSLGITAIELAKGE 212
Query: 853 PLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEH 912
P + + M VL + P + + + LN + RPT ELL +
Sbjct: 213 PPNSDLHPMRVLFLIPKNS---PPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKF 269
Query: 913 VPR 915
+ R
Sbjct: 270 ITR 272
Score = 41.9 bits (94), Expect = 0.018
Identities = 28/85 (32%), Positives = 48/85 (56%), Gaps = 4/85 (4%)
Query: 524 FANNGLSRLDAE--FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKIT 581
FAN SR+D E F L +GKG+FG+V K + AIK + L ++ + I
Sbjct: 7 FANQH-SRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEI-EDIQ 64
Query: 582 REVKLLSRLNHENVVRYYNAWIEST 606
+E+ +LS+ + + RY+ ++++ST
Sbjct: 65 QEITVLSQCDSPYITRYFGSYLKST 89
Score = 39.1 bits (87), Expect = 0.12
Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 21/163 (12%)
Query: 256 LGHSSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSNASL 315
+G S G Y ID+ T E + K + A D ++ IQQ++ L++ + +
Sbjct: 26 IGKGSFGEV-YKGIDNHTKEVVAIKIIDLEEAED------EIEDIQQEITVLSQCDSPYI 78
Query: 316 IPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGV 375
Y + +++K ++I ++ G S +L+K G + + +LR + G
Sbjct: 79 TRYFGSYL------KSTK--LWIIMEYLGGGSALDLLKP--GPLEETYIATILREILKG- 127
Query: 376 LSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAE 418
L+ LH+ IHRD+++ NV + + G VKL + +L +
Sbjct: 128 ---LDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTD 167
>AB067488-1|BAB67794.1| 1265|Homo sapiens KIAA1901 protein protein.
Length = 1265
Score = 72.1 bits (169), Expect = 1e-11
Identities = 56/155 (36%), Positives = 83/155 (53%), Gaps = 23/155 (14%)
Query: 716 LYIQMEFCEKHTLRQAID---NGLFQE-HFRAWRLFREIVEGLAHVHQRGMIHRDLKPVN 771
LYI M++CE L + I+ LFQE W F +I L HVH R ++HRD+K N
Sbjct: 83 LYIVMDYCEGGDLFKRINAQKGVLFQEDQILDW--FVQICLALKHVHDRKILHRDIKSQN 140
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
IFL + V++GDFG+A V + T E+ + IGT Y++PE+ ++
Sbjct: 141 IFLTKDGTVQLGDFGIAR-------VLNST--VELARTC---IGTPYYLSPEICENKP-- 186
Query: 832 IYNQKVDIYSLGIILFEM--FHPPLETGMERMMVL 864
YN K DI++LG +L+E+ E G + +VL
Sbjct: 187 -YNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVL 220
Score = 48.8 bits (111), Expect = 2e-04
Identities = 23/75 (30%), Positives = 45/75 (60%)
Query: 531 RLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL 590
R+ ++ L +G+G+FG + VK+ DG Y IK + ++ S + ++ REV +L+ +
Sbjct: 6 RIMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANM 65
Query: 591 NHENVVRYYNAWIES 605
H N+V+Y ++ E+
Sbjct: 66 KHPNIVQYRESFEEN 80
Score = 34.3 bits (75), Expect = 3.5
Identities = 13/30 (43%), Positives = 21/30 (70%)
Query: 378 ALNELHAANIIHRDVRSENVFVDDVGQVKL 407
AL +H I+HRD++S+N+F+ G V+L
Sbjct: 122 ALKHVHDRKILHRDIKSQNIFLTKDGTVQL 151
>Z11694-1|CAA77752.1| 360|Homo sapiens 41kD protein kinase protein.
Length = 360
Score = 71.7 bits (168), Expect = 2e-11
Identities = 52/150 (34%), Positives = 80/150 (53%), Gaps = 16/150 (10%)
Query: 700 DVVDAPRPQSERLKQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQ 759
D++ AP E++K V YI + E + L +H + L+ +I+ GL ++H
Sbjct: 88 DIIQAPT--IEQMKDV-YIVQDLMETDLYKLLKTQHLSNDHI-CYFLY-QILRGLKYIHS 142
Query: 760 RGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALY 819
++HRDLKP N+ L++ +KI DFGLA A P D T G LT + T Y
Sbjct: 143 ANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD---PDHDHT------GFLTEYVATRWY 193
Query: 820 VAPELLQSATKVIYNQKVDIYSLGIILFEM 849
APE++ ++ Y + +DI+S+G IL EM
Sbjct: 194 RAPEIMLNSKG--YTKSIDIWSVGCILAEM 221
Score = 36.3 bits (80), Expect = 0.87
Identities = 17/58 (29%), Positives = 33/58 (56%), Gaps = 1/58 (1%)
Query: 539 LAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENVV 596
L+++G+GA+G V + ++ AIK++ + + RE+K+L R HEN++
Sbjct: 28 LSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTL-REIKILLRFRHENII 84
>X69117-1|CAA48870.1| 688|Homo sapiens beta-adrenergic kinase 2
protein.
Length = 688
Score = 71.3 bits (167), Expect = 3e-11
Identities = 57/173 (32%), Positives = 86/173 (49%), Gaps = 28/173 (16%)
Query: 734 NGLFQEHFRAWRLFR-EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAF 792
+G+F E + R + EI+ GL HVH R +++RDLKP NI LD + H +I D GLA
Sbjct: 286 HGVFSE--KEMRFYATEIILGLEHVHNRFVVYRDLKPANILLDEHGHARISDLGLAC--- 340
Query: 793 TGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMF-- 850
D +K++ +GT Y+APE+LQ T Y+ D +SLG +LF++
Sbjct: 341 ------DFSKKKP-----HASVGTHGYMAPEVLQKGT--AYDSSADWFSLGCMLFKLLRG 387
Query: 851 HPPL-------ETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNH 896
H P + ++RM + N+ D P + E + Q V + L H
Sbjct: 388 HSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCH 440
>M95712-1|AAA35609.2| 766|Homo sapiens B-raf protein protein.
Length = 766
Score = 71.3 bits (167), Expect = 3e-11
Identities = 60/214 (28%), Positives = 107/214 (50%), Gaps = 19/214 (8%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLF---REIVEGLAHVHQRGMIHRDLKP 769
K L I ++CE +L + + + F +L R+ +G+ ++H + +IHRDLK
Sbjct: 522 KPQLAIVTQWCEGSSLYHHLH--IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKS 579
Query: 770 VNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSAT 829
NIFL + VKIGDFGLAT V+ + L+G I L++APE+++
Sbjct: 580 NNIFLHEDLTVKIGDFGLAT-------VKSRWSGSHQFEQLSGSI---LWMAPEVIRMQD 629
Query: 830 KVIYNQKVDIYSLGIILFEMFHPPLE-TGMERMMVLTNLRSKDIVIPNKFDVDENVKQI- 887
K Y+ + D+Y+ GI+L+E+ L + + + + + + P+ V N +
Sbjct: 630 KNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAM 689
Query: 888 -HVIRWLLNHEASLRPTCAELLAS-EHVPRAVPE 919
++ L + RP ++LAS E + R++P+
Sbjct: 690 KRLMAECLKKKRDERPLFPQILASIELLARSLPK 723
Score = 36.3 bits (80), Expect = 0.87
Identities = 19/53 (35%), Positives = 32/53 (60%), Gaps = 1/53 (1%)
Query: 362 FEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDT 414
FE++ L+ +A ++ LHA +IIHRD++S N+F+ + VK+ L T
Sbjct: 548 FEMIKLI-DIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLAT 599
>M21001-1|AAA96495.1| 328|Homo sapiens B-raf protein protein.
Length = 328
Score = 71.3 bits (167), Expect = 3e-11
Identities = 60/214 (28%), Positives = 107/214 (50%), Gaps = 19/214 (8%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLF---REIVEGLAHVHQRGMIHRDLKP 769
K L I ++CE +L + + + F +L R+ +G+ ++H + +IHRDLK
Sbjct: 84 KPQLAIVTQWCEGSSLYHHLH--IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKS 141
Query: 770 VNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSAT 829
NIFL + VKIGDFGLAT V+ + L+G I L++APE+++
Sbjct: 142 NNIFLHEDLTVKIGDFGLAT-------VKSRWSGSHQFEQLSGSI---LWMAPEVIRMQD 191
Query: 830 KVIYNQKVDIYSLGIILFEMFHPPLE-TGMERMMVLTNLRSKDIVIPNKFDVDENVKQI- 887
K Y+ + D+Y+ GI+L+E+ L + + + + + + P+ V N +
Sbjct: 192 KNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAM 251
Query: 888 -HVIRWLLNHEASLRPTCAELLAS-EHVPRAVPE 919
++ L + RP ++LAS E + R++P+
Sbjct: 252 KRLMAECLKKKRDERPLFPQILASIELLARSLPK 285
Score = 36.3 bits (80), Expect = 0.87
Identities = 19/53 (35%), Positives = 32/53 (60%), Gaps = 1/53 (1%)
Query: 362 FEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDT 414
FE++ L+ +A ++ LHA +IIHRD++S N+F+ + VK+ L T
Sbjct: 110 FEMIKLI-DIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLAT 161
>BC112079-1|AAI12080.1| 766|Homo sapiens v-raf murine sarcoma viral
oncogene homolog B1 protein.
Length = 766
Score = 71.3 bits (167), Expect = 3e-11
Identities = 60/214 (28%), Positives = 107/214 (50%), Gaps = 19/214 (8%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLF---REIVEGLAHVHQRGMIHRDLKP 769
K L I ++CE +L + + + F +L R+ +G+ ++H + +IHRDLK
Sbjct: 522 KPQLAIVTQWCEGSSLYHHLH--IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKS 579
Query: 770 VNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSAT 829
NIFL + VKIGDFGLAT V+ + L+G I L++APE+++
Sbjct: 580 NNIFLHEDLTVKIGDFGLAT-------VKSRWSGSHQFEQLSGSI---LWMAPEVIRMQD 629
Query: 830 KVIYNQKVDIYSLGIILFEMFHPPLE-TGMERMMVLTNLRSKDIVIPNKFDVDENVKQI- 887
K Y+ + D+Y+ GI+L+E+ L + + + + + + P+ V N +
Sbjct: 630 KNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAM 689
Query: 888 -HVIRWLLNHEASLRPTCAELLAS-EHVPRAVPE 919
++ L + RP ++LAS E + R++P+
Sbjct: 690 KRLMAECLKKKRDERPLFPQILASIELLARSLPK 723
Score = 36.3 bits (80), Expect = 0.87
Identities = 19/53 (35%), Positives = 32/53 (60%), Gaps = 1/53 (1%)
Query: 362 FEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDT 414
FE++ L+ +A ++ LHA +IIHRD++S N+F+ + VK+ L T
Sbjct: 548 FEMIKLI-DIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLAT 599
>BC101757-1|AAI01758.1| 766|Homo sapiens v-raf murine sarcoma viral
oncogene homolog B1 protein.
Length = 766
Score = 71.3 bits (167), Expect = 3e-11
Identities = 60/214 (28%), Positives = 107/214 (50%), Gaps = 19/214 (8%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLF---REIVEGLAHVHQRGMIHRDLKP 769
K L I ++CE +L + + + F +L R+ +G+ ++H + +IHRDLK
Sbjct: 522 KPQLAIVTQWCEGSSLYHHLH--IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKS 579
Query: 770 VNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSAT 829
NIFL + VKIGDFGLAT V+ + L+G I L++APE+++
Sbjct: 580 NNIFLHEDLTVKIGDFGLAT-------VKSRWSGSHQFEQLSGSI---LWMAPEVIRMQD 629
Query: 830 KVIYNQKVDIYSLGIILFEMFHPPLE-TGMERMMVLTNLRSKDIVIPNKFDVDENVKQI- 887
K Y+ + D+Y+ GI+L+E+ L + + + + + + P+ V N +
Sbjct: 630 KNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAM 689
Query: 888 -HVIRWLLNHEASLRPTCAELLAS-EHVPRAVPE 919
++ L + RP ++LAS E + R++P+
Sbjct: 690 KRLMAECLKKKRDERPLFPQILASIELLARSLPK 723
Score = 36.3 bits (80), Expect = 0.87
Identities = 19/53 (35%), Positives = 32/53 (60%), Gaps = 1/53 (1%)
Query: 362 FEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDT 414
FE++ L+ +A ++ LHA +IIHRD++S N+F+ + VK+ L T
Sbjct: 548 FEMIKLI-DIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLAT 599
>AY803272-1|AAW30454.1| 1492|Homo sapiens AKAP9-BRAF fusion protein
protein.
Length = 1492
Score = 71.3 bits (167), Expect = 3e-11
Identities = 60/214 (28%), Positives = 107/214 (50%), Gaps = 19/214 (8%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLF---REIVEGLAHVHQRGMIHRDLKP 769
K L I ++CE +L + + + F +L R+ +G+ ++H + +IHRDLK
Sbjct: 1248 KPQLAIVTQWCEGSSLYHHLH--IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKS 1305
Query: 770 VNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSAT 829
NIFL + VKIGDFGLAT V+ + L+G I L++APE+++
Sbjct: 1306 NNIFLHEDLTVKIGDFGLAT-------VKSRWSGSHQFEQLSGSI---LWMAPEVIRMQD 1355
Query: 830 KVIYNQKVDIYSLGIILFEMFHPPLE-TGMERMMVLTNLRSKDIVIPNKFDVDENVKQI- 887
K Y+ + D+Y+ GI+L+E+ L + + + + + + P+ V N +
Sbjct: 1356 KNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAM 1415
Query: 888 -HVIRWLLNHEASLRPTCAELLAS-EHVPRAVPE 919
++ L + RP ++LAS E + R++P+
Sbjct: 1416 KRLMAECLKKKRDERPLFPQILASIELLARSLPK 1449
Score = 36.3 bits (80), Expect = 0.87
Identities = 19/53 (35%), Positives = 32/53 (60%), Gaps = 1/53 (1%)
Query: 362 FEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDT 414
FE++ L+ +A ++ LHA +IIHRD++S N+F+ + VK+ L T
Sbjct: 1274 FEMIKLI-DIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLAT 1325
>AC006344-3|AAD43193.1| 651|Homo sapiens WUGSC:H_DJ0726N20.3
protein.
Length = 651
Score = 71.3 bits (167), Expect = 3e-11
Identities = 60/214 (28%), Positives = 107/214 (50%), Gaps = 19/214 (8%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLF---REIVEGLAHVHQRGMIHRDLKP 769
K L I ++CE +L + + + F +L R+ +G+ ++H + +IHRDLK
Sbjct: 407 KPQLAIVTQWCEGSSLYHHLH--IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKS 464
Query: 770 VNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSAT 829
NIFL + VKIGDFGLAT V+ + L+G I L++APE+++
Sbjct: 465 NNIFLHEDLTVKIGDFGLAT-------VKSRWSGSHQFEQLSGSI---LWMAPEVIRMQD 514
Query: 830 KVIYNQKVDIYSLGIILFEMFHPPLE-TGMERMMVLTNLRSKDIVIPNKFDVDENVKQI- 887
K Y+ + D+Y+ GI+L+E+ L + + + + + + P+ V N +
Sbjct: 515 KNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAM 574
Query: 888 -HVIRWLLNHEASLRPTCAELLAS-EHVPRAVPE 919
++ L + RP ++LAS E + R++P+
Sbjct: 575 KRLMAECLKKKRDERPLFPQILASIELLARSLPK 608
Score = 36.3 bits (80), Expect = 0.87
Identities = 19/53 (35%), Positives = 32/53 (60%), Gaps = 1/53 (1%)
Query: 362 FEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDT 414
FE++ L+ +A ++ LHA +IIHRD++S N+F+ + VK+ L T
Sbjct: 433 FEMIKLI-DIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLAT 484
>Z11695-1|CAA77753.1| 348|Homo sapiens 40kDa protein kinase
protein.
Length = 348
Score = 70.9 bits (166), Expect = 3e-11
Identities = 52/150 (34%), Positives = 80/150 (53%), Gaps = 16/150 (10%)
Query: 700 DVVDAPRPQSERLKQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQ 759
D++ AP E++K V YI + E + L +H + L+ +I+ GL ++H
Sbjct: 76 DIIRAPT--IEQMKDV-YIVQDLMETDLYKLLKTQHLSNDHI-CYFLY-QILRGLKYIHS 130
Query: 760 RGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALY 819
++HRDLKP N+ L++ +KI DFGLA A P D T G LT + T Y
Sbjct: 131 ANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD---PDHDHT------GFLTEYVATRWY 181
Query: 820 VAPELLQSATKVIYNQKVDIYSLGIILFEM 849
APE++ ++ Y + +DI+S+G IL EM
Sbjct: 182 RAPEIMLNSKG--YTKSIDIWSVGCILAEM 209
Score = 36.3 bits (80), Expect = 0.87
Identities = 17/58 (29%), Positives = 33/58 (56%), Gaps = 1/58 (1%)
Query: 539 LAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENVV 596
L+++G+GA+G V + ++ AIK++ + + RE+K+L R HEN++
Sbjct: 16 LSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTL-REIKILLRFRHENII 72
>M84489-1|AAA58459.1| 360|Homo sapiens protein kinase 2 protein.
Length = 360
Score = 70.9 bits (166), Expect = 3e-11
Identities = 52/150 (34%), Positives = 80/150 (53%), Gaps = 16/150 (10%)
Query: 700 DVVDAPRPQSERLKQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQ 759
D++ AP E++K V YI + E + L +H + L+ +I+ GL ++H
Sbjct: 88 DIIRAPT--IEQMKDV-YIVQDLMETDLYKLLKTQHLSNDHI-CYFLY-QILRGLKYIHS 142
Query: 760 RGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALY 819
++HRDLKP N+ L++ +KI DFGLA A P D T G LT + T Y
Sbjct: 143 ANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD---PDHDHT------GFLTEYVATRWY 193
Query: 820 VAPELLQSATKVIYNQKVDIYSLGIILFEM 849
APE++ ++ Y + +DI+S+G IL EM
Sbjct: 194 RAPEIMLNSKG--YTKSIDIWSVGCILAEM 221
Score = 36.3 bits (80), Expect = 0.87
Identities = 17/58 (29%), Positives = 33/58 (56%), Gaps = 1/58 (1%)
Query: 539 LAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENVV 596
L+++G+GA+G V + ++ AIK++ + + RE+K+L R HEN++
Sbjct: 28 LSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTL-REIKILLRFRHENII 84
>DQ508104-1|ABF47102.1| 360|Homo sapiens mitogen-activated protein
kinase 1 protein.
Length = 360
Score = 70.9 bits (166), Expect = 3e-11
Identities = 52/150 (34%), Positives = 80/150 (53%), Gaps = 16/150 (10%)
Query: 700 DVVDAPRPQSERLKQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQ 759
D++ AP E++K V YI + E + L +H + L+ +I+ GL ++H
Sbjct: 88 DIIRAPT--IEQMKDV-YIVQDLMETDLYKLLKTQHLSNDHI-CYFLY-QILRGLKYIHS 142
Query: 760 RGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALY 819
++HRDLKP N+ L++ +KI DFGLA A P D T G LT + T Y
Sbjct: 143 ANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD---PDHDHT------GFLTEYVATRWY 193
Query: 820 VAPELLQSATKVIYNQKVDIYSLGIILFEM 849
APE++ ++ Y + +DI+S+G IL EM
Sbjct: 194 RAPEIMLNSKG--YTKSIDIWSVGCILAEM 221
Score = 36.3 bits (80), Expect = 0.87
Identities = 17/58 (29%), Positives = 33/58 (56%), Gaps = 1/58 (1%)
Query: 539 LAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENVV 596
L+++G+GA+G V + ++ AIK++ + + RE+K+L R HEN++
Sbjct: 28 LSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTL-REIKILLRFRHENII 84
>BC017832-1|AAH17832.1| 360|Homo sapiens mitogen-activated protein
kinase 1 protein.
Length = 360
Score = 70.9 bits (166), Expect = 3e-11
Identities = 52/150 (34%), Positives = 80/150 (53%), Gaps = 16/150 (10%)
Query: 700 DVVDAPRPQSERLKQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQ 759
D++ AP E++K V YI + E + L +H + L+ +I+ GL ++H
Sbjct: 88 DIIRAPT--IEQMKDV-YIVQDLMETDLYKLLKTQHLSNDHI-CYFLY-QILRGLKYIHS 142
Query: 760 RGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALY 819
++HRDLKP N+ L++ +KI DFGLA A P D T G LT + T Y
Sbjct: 143 ANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD---PDHDHT------GFLTEYVATRWY 193
Query: 820 VAPELLQSATKVIYNQKVDIYSLGIILFEM 849
APE++ ++ Y + +DI+S+G IL EM
Sbjct: 194 RAPEIMLNSKG--YTKSIDIWSVGCILAEM 221
Score = 36.3 bits (80), Expect = 0.87
Identities = 17/58 (29%), Positives = 33/58 (56%), Gaps = 1/58 (1%)
Query: 539 LAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENVV 596
L+++G+GA+G V + ++ AIK++ + + RE+K+L R HEN++
Sbjct: 28 LSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTL-REIKILLRFRHENII 84
>AF172271-1|AAF03789.1| 1268|Homo sapiens Traf2 and NCK interacting
kinase, splice variant 8 protein.
Length = 1268
Score = 70.9 bits (166), Expect = 3e-11
Identities = 51/146 (34%), Positives = 77/146 (52%), Gaps = 20/146 (13%)
Query: 716 LYIQMEFCEKHTLRQAIDN---GLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
L++ MEFC ++ I N +E + A+ + REI+ GL+H+HQ +IHRD+K N+
Sbjct: 101 LWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAY-ICREILRGLSHLHQHKVIHRDIKGQNV 159
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELL--QSATK 830
L N VK+ DFG++ + D+T G IGT ++APE++
Sbjct: 160 LLTENAEVKLVDFGVSAQL-------DRTV-----GRRNTFIGTPYWMAPEVIACDENPD 207
Query: 831 VIYNQKVDIYSLGIILFEMFH--PPL 854
Y+ K D++SLGI EM PPL
Sbjct: 208 ATYDFKSDLWSLGITAIEMAEGAPPL 233
Score = 39.9 bits (89), Expect = 0.071
Identities = 29/125 (23%), Positives = 57/125 (45%), Gaps = 4/125 (3%)
Query: 300 IQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFS 359
I+Q++ L + S+ I K+ N +++ F S+ +L+K G +
Sbjct: 66 IKQEINMLKKYSHHRNIATYYGAFIKK-NPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT 124
Query: 360 DCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAEM 419
E + ++ +L L+ LH +IHRD++ +NV + + +VKLV + +L
Sbjct: 125 LKEEWIA---YICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 420 LDNDN 424
+ N
Sbjct: 182 VGRRN 186
Score = 39.5 bits (88), Expect = 0.094
Identities = 21/77 (27%), Positives = 41/77 (53%), Gaps = 4/77 (5%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL-NHEN 594
FE++ +G G +G V K ++ G AIK + + + ++I +E+ +L + +H N
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDE---EEEIKQEINMLKKYSHHRN 81
Query: 595 VVRYYNAWIESTTEPID 611
+ YY A+I+ +D
Sbjct: 82 IATYYGAFIKKNPPGMD 98
>AF172270-1|AAF03788.1| 1297|Homo sapiens Traf2 and NCK interacting
kinase, splice variant 7 protein.
Length = 1297
Score = 70.9 bits (166), Expect = 3e-11
Identities = 51/146 (34%), Positives = 77/146 (52%), Gaps = 20/146 (13%)
Query: 716 LYIQMEFCEKHTLRQAIDN---GLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
L++ MEFC ++ I N +E + A+ + REI+ GL+H+HQ +IHRD+K N+
Sbjct: 101 LWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAY-ICREILRGLSHLHQHKVIHRDIKGQNV 159
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELL--QSATK 830
L N VK+ DFG++ + D+T G IGT ++APE++
Sbjct: 160 LLTENAEVKLVDFGVSAQL-------DRTV-----GRRNTFIGTPYWMAPEVIACDENPD 207
Query: 831 VIYNQKVDIYSLGIILFEMFH--PPL 854
Y+ K D++SLGI EM PPL
Sbjct: 208 ATYDFKSDLWSLGITAIEMAEGAPPL 233
Score = 39.9 bits (89), Expect = 0.071
Identities = 29/125 (23%), Positives = 57/125 (45%), Gaps = 4/125 (3%)
Query: 300 IQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFS 359
I+Q++ L + S+ I K+ N +++ F S+ +L+K G +
Sbjct: 66 IKQEINMLKKYSHHRNIATYYGAFIKK-NPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT 124
Query: 360 DCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAEM 419
E + ++ +L L+ LH +IHRD++ +NV + + +VKLV + +L
Sbjct: 125 LKEEWIA---YICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 420 LDNDN 424
+ N
Sbjct: 182 VGRRN 186
Score = 39.5 bits (88), Expect = 0.094
Identities = 21/77 (27%), Positives = 41/77 (53%), Gaps = 4/77 (5%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL-NHEN 594
FE++ +G G +G V K ++ G AIK + + + ++I +E+ +L + +H N
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDE---EEEIKQEINMLKKYSHHRN 81
Query: 595 VVRYYNAWIESTTEPID 611
+ YY A+I+ +D
Sbjct: 82 IATYYGAFIKKNPPGMD 98
>AF172269-1|AAF03787.1| 1323|Homo sapiens Traf2 and NCK interacting
kinase, splice variant 6 protein.
Length = 1323
Score = 70.9 bits (166), Expect = 3e-11
Identities = 51/146 (34%), Positives = 77/146 (52%), Gaps = 20/146 (13%)
Query: 716 LYIQMEFCEKHTLRQAIDN---GLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
L++ MEFC ++ I N +E + A+ + REI+ GL+H+HQ +IHRD+K N+
Sbjct: 101 LWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAY-ICREILRGLSHLHQHKVIHRDIKGQNV 159
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELL--QSATK 830
L N VK+ DFG++ + D+T G IGT ++APE++
Sbjct: 160 LLTENAEVKLVDFGVSAQL-------DRTV-----GRRNTFIGTPYWMAPEVIACDENPD 207
Query: 831 VIYNQKVDIYSLGIILFEMFH--PPL 854
Y+ K D++SLGI EM PPL
Sbjct: 208 ATYDFKSDLWSLGITAIEMAEGAPPL 233
Score = 39.9 bits (89), Expect = 0.071
Identities = 29/125 (23%), Positives = 57/125 (45%), Gaps = 4/125 (3%)
Query: 300 IQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFS 359
I+Q++ L + S+ I K+ N +++ F S+ +L+K G +
Sbjct: 66 IKQEINMLKKYSHHRNIATYYGAFIKK-NPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT 124
Query: 360 DCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAEM 419
E + ++ +L L+ LH +IHRD++ +NV + + +VKLV + +L
Sbjct: 125 LKEEWIA---YICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 420 LDNDN 424
+ N
Sbjct: 182 VGRRN 186
Score = 39.5 bits (88), Expect = 0.094
Identities = 21/77 (27%), Positives = 41/77 (53%), Gaps = 4/77 (5%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL-NHEN 594
FE++ +G G +G V K ++ G AIK + + + ++I +E+ +L + +H N
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDE---EEEIKQEINMLKKYSHHRN 81
Query: 595 VVRYYNAWIESTTEPID 611
+ YY A+I+ +D
Sbjct: 82 IATYYGAFIKKNPPGMD 98
>AF172268-1|AAF03786.1| 1276|Homo sapiens Traf2 and NCK interacting
kinase, splice variant 5 protein.
Length = 1276
Score = 70.9 bits (166), Expect = 3e-11
Identities = 51/146 (34%), Positives = 77/146 (52%), Gaps = 20/146 (13%)
Query: 716 LYIQMEFCEKHTLRQAIDN---GLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
L++ MEFC ++ I N +E + A+ + REI+ GL+H+HQ +IHRD+K N+
Sbjct: 101 LWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAY-ICREILRGLSHLHQHKVIHRDIKGQNV 159
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELL--QSATK 830
L N VK+ DFG++ + D+T G IGT ++APE++
Sbjct: 160 LLTENAEVKLVDFGVSAQL-------DRTV-----GRRNTFIGTPYWMAPEVIACDENPD 207
Query: 831 VIYNQKVDIYSLGIILFEMFH--PPL 854
Y+ K D++SLGI EM PPL
Sbjct: 208 ATYDFKSDLWSLGITAIEMAEGAPPL 233
Score = 39.9 bits (89), Expect = 0.071
Identities = 29/125 (23%), Positives = 57/125 (45%), Gaps = 4/125 (3%)
Query: 300 IQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFS 359
I+Q++ L + S+ I K+ N +++ F S+ +L+K G +
Sbjct: 66 IKQEINMLKKYSHHRNIATYYGAFIKK-NPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT 124
Query: 360 DCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAEM 419
E + ++ +L L+ LH +IHRD++ +NV + + +VKLV + +L
Sbjct: 125 LKEEWIA---YICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 420 LDNDN 424
+ N
Sbjct: 182 VGRRN 186
Score = 39.5 bits (88), Expect = 0.094
Identities = 21/77 (27%), Positives = 41/77 (53%), Gaps = 4/77 (5%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL-NHEN 594
FE++ +G G +G V K ++ G AIK + + + ++I +E+ +L + +H N
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDE---EEEIKQEINMLKKYSHHRN 81
Query: 595 VVRYYNAWIESTTEPID 611
+ YY A+I+ +D
Sbjct: 82 IATYYGAFIKKNPPGMD 98
>AF172267-1|AAF03785.1| 1352|Homo sapiens Traf2 and NCK interacting
kinase, splice variant 4 protein.
Length = 1352
Score = 70.9 bits (166), Expect = 3e-11
Identities = 51/146 (34%), Positives = 77/146 (52%), Gaps = 20/146 (13%)
Query: 716 LYIQMEFCEKHTLRQAIDN---GLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
L++ MEFC ++ I N +E + A+ + REI+ GL+H+HQ +IHRD+K N+
Sbjct: 101 LWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAY-ICREILRGLSHLHQHKVIHRDIKGQNV 159
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELL--QSATK 830
L N VK+ DFG++ + D+T G IGT ++APE++
Sbjct: 160 LLTENAEVKLVDFGVSAQL-------DRTV-----GRRNTFIGTPYWMAPEVIACDENPD 207
Query: 831 VIYNQKVDIYSLGIILFEMFH--PPL 854
Y+ K D++SLGI EM PPL
Sbjct: 208 ATYDFKSDLWSLGITAIEMAEGAPPL 233
Score = 39.9 bits (89), Expect = 0.071
Identities = 29/125 (23%), Positives = 57/125 (45%), Gaps = 4/125 (3%)
Query: 300 IQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFS 359
I+Q++ L + S+ I K+ N +++ F S+ +L+K G +
Sbjct: 66 IKQEINMLKKYSHHRNIATYYGAFIKK-NPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT 124
Query: 360 DCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAEM 419
E + ++ +L L+ LH +IHRD++ +NV + + +VKLV + +L
Sbjct: 125 LKEEWIA---YICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 420 LDNDN 424
+ N
Sbjct: 182 VGRRN 186
Score = 39.5 bits (88), Expect = 0.094
Identities = 21/77 (27%), Positives = 41/77 (53%), Gaps = 4/77 (5%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL-NHEN 594
FE++ +G G +G V K ++ G AIK + + + ++I +E+ +L + +H N
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDE---EEEIKQEINMLKKYSHHRN 81
Query: 595 VVRYYNAWIESTTEPID 611
+ YY A+I+ +D
Sbjct: 82 IATYYGAFIKKNPPGMD 98
>AF172266-1|AAF03784.1| 1305|Homo sapiens Traf2 and NCK interacting
kinase, splice variant 3 protein.
Length = 1305
Score = 70.9 bits (166), Expect = 3e-11
Identities = 51/146 (34%), Positives = 77/146 (52%), Gaps = 20/146 (13%)
Query: 716 LYIQMEFCEKHTLRQAIDN---GLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
L++ MEFC ++ I N +E + A+ + REI+ GL+H+HQ +IHRD+K N+
Sbjct: 101 LWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAY-ICREILRGLSHLHQHKVIHRDIKGQNV 159
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELL--QSATK 830
L N VK+ DFG++ + D+T G IGT ++APE++
Sbjct: 160 LLTENAEVKLVDFGVSAQL-------DRTV-----GRRNTFIGTPYWMAPEVIACDENPD 207
Query: 831 VIYNQKVDIYSLGIILFEMFH--PPL 854
Y+ K D++SLGI EM PPL
Sbjct: 208 ATYDFKSDLWSLGITAIEMAEGAPPL 233
Score = 39.9 bits (89), Expect = 0.071
Identities = 29/125 (23%), Positives = 57/125 (45%), Gaps = 4/125 (3%)
Query: 300 IQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFS 359
I+Q++ L + S+ I K+ N +++ F S+ +L+K G +
Sbjct: 66 IKQEINMLKKYSHHRNIATYYGAFIKK-NPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT 124
Query: 360 DCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAEM 419
E + ++ +L L+ LH +IHRD++ +NV + + +VKLV + +L
Sbjct: 125 LKEEWIA---YICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 420 LDNDN 424
+ N
Sbjct: 182 VGRRN 186
Score = 39.5 bits (88), Expect = 0.094
Identities = 21/77 (27%), Positives = 41/77 (53%), Gaps = 4/77 (5%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL-NHEN 594
FE++ +G G +G V K ++ G AIK + + + ++I +E+ +L + +H N
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDE---EEEIKQEINMLKKYSHHRN 81
Query: 595 VVRYYNAWIESTTEPID 611
+ YY A+I+ +D
Sbjct: 82 IATYYGAFIKKNPPGMD 98
>AF172265-1|AAF03783.1| 1331|Homo sapiens Traf2 and NCK interacting
kinase, splice variant 2 protein.
Length = 1331
Score = 70.9 bits (166), Expect = 3e-11
Identities = 51/146 (34%), Positives = 77/146 (52%), Gaps = 20/146 (13%)
Query: 716 LYIQMEFCEKHTLRQAIDN---GLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
L++ MEFC ++ I N +E + A+ + REI+ GL+H+HQ +IHRD+K N+
Sbjct: 101 LWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAY-ICREILRGLSHLHQHKVIHRDIKGQNV 159
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELL--QSATK 830
L N VK+ DFG++ + D+T G IGT ++APE++
Sbjct: 160 LLTENAEVKLVDFGVSAQL-------DRTV-----GRRNTFIGTPYWMAPEVIACDENPD 207
Query: 831 VIYNQKVDIYSLGIILFEMFH--PPL 854
Y+ K D++SLGI EM PPL
Sbjct: 208 ATYDFKSDLWSLGITAIEMAEGAPPL 233
Score = 39.9 bits (89), Expect = 0.071
Identities = 29/125 (23%), Positives = 57/125 (45%), Gaps = 4/125 (3%)
Query: 300 IQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFS 359
I+Q++ L + S+ I K+ N +++ F S+ +L+K G +
Sbjct: 66 IKQEINMLKKYSHHRNIATYYGAFIKK-NPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT 124
Query: 360 DCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAEM 419
E + ++ +L L+ LH +IHRD++ +NV + + +VKLV + +L
Sbjct: 125 LKEEWIA---YICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 420 LDNDN 424
+ N
Sbjct: 182 VGRRN 186
Score = 39.5 bits (88), Expect = 0.094
Identities = 21/77 (27%), Positives = 41/77 (53%), Gaps = 4/77 (5%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL-NHEN 594
FE++ +G G +G V K ++ G AIK + + + ++I +E+ +L + +H N
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDE---EEEIKQEINMLKKYSHHRN 81
Query: 595 VVRYYNAWIESTTEPID 611
+ YY A+I+ +D
Sbjct: 82 IATYYGAFIKKNPPGMD 98
>AF172264-1|AAF03782.1| 1360|Homo sapiens Traf2 and NCK interacting
kinase, splice variant 1 protein.
Length = 1360
Score = 70.9 bits (166), Expect = 3e-11
Identities = 51/146 (34%), Positives = 77/146 (52%), Gaps = 20/146 (13%)
Query: 716 LYIQMEFCEKHTLRQAIDN---GLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
L++ MEFC ++ I N +E + A+ + REI+ GL+H+HQ +IHRD+K N+
Sbjct: 101 LWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAY-ICREILRGLSHLHQHKVIHRDIKGQNV 159
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELL--QSATK 830
L N VK+ DFG++ + D+T G IGT ++APE++
Sbjct: 160 LLTENAEVKLVDFGVSAQL-------DRTV-----GRRNTFIGTPYWMAPEVIACDENPD 207
Query: 831 VIYNQKVDIYSLGIILFEMFH--PPL 854
Y+ K D++SLGI EM PPL
Sbjct: 208 ATYDFKSDLWSLGITAIEMAEGAPPL 233
Score = 39.9 bits (89), Expect = 0.071
Identities = 29/125 (23%), Positives = 57/125 (45%), Gaps = 4/125 (3%)
Query: 300 IQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFS 359
I+Q++ L + S+ I K+ N +++ F S+ +L+K G +
Sbjct: 66 IKQEINMLKKYSHHRNIATYYGAFIKK-NPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT 124
Query: 360 DCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAEM 419
E + ++ +L L+ LH +IHRD++ +NV + + +VKLV + +L
Sbjct: 125 LKEEWIA---YICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 420 LDNDN 424
+ N
Sbjct: 182 VGRRN 186
Score = 39.5 bits (88), Expect = 0.094
Identities = 21/77 (27%), Positives = 41/77 (53%), Gaps = 4/77 (5%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL-NHEN 594
FE++ +G G +G V K ++ G AIK + + + ++I +E+ +L + +H N
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDE---EEEIKQEINMLKKYSHHRN 81
Query: 595 VVRYYNAWIESTTEPID 611
+ YY A+I+ +D
Sbjct: 82 IATYYGAFIKKNPPGMD 98
>AB011123-1|BAA25477.2| 1385|Homo sapiens KIAA0551 protein protein.
Length = 1385
Score = 70.9 bits (166), Expect = 3e-11
Identities = 51/146 (34%), Positives = 77/146 (52%), Gaps = 20/146 (13%)
Query: 716 LYIQMEFCEKHTLRQAIDN---GLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
L++ MEFC ++ I N +E + A+ + REI+ GL+H+HQ +IHRD+K N+
Sbjct: 126 LWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAY-ICREILRGLSHLHQHKVIHRDIKGQNV 184
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELL--QSATK 830
L N VK+ DFG++ + D+T G IGT ++APE++
Sbjct: 185 LLTENAEVKLVDFGVSAQL-------DRTV-----GRRNTFIGTPYWMAPEVIACDENPD 232
Query: 831 VIYNQKVDIYSLGIILFEMFH--PPL 854
Y+ K D++SLGI EM PPL
Sbjct: 233 ATYDFKSDLWSLGITAIEMAEGAPPL 258
Score = 39.9 bits (89), Expect = 0.071
Identities = 29/125 (23%), Positives = 57/125 (45%), Gaps = 4/125 (3%)
Query: 300 IQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFS 359
I+Q++ L + S+ I K+ N +++ F S+ +L+K G +
Sbjct: 91 IKQEINMLKKYSHHRNIATYYGAFIKK-NPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT 149
Query: 360 DCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAEM 419
E + ++ +L L+ LH +IHRD++ +NV + + +VKLV + +L
Sbjct: 150 LKEEWIA---YICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 206
Query: 420 LDNDN 424
+ N
Sbjct: 207 VGRRN 211
Score = 39.5 bits (88), Expect = 0.094
Identities = 21/77 (27%), Positives = 41/77 (53%), Gaps = 4/77 (5%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRL-NHEN 594
FE++ +G G +G V K ++ G AIK + + + ++I +E+ +L + +H N
Sbjct: 50 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDE---EEEIKQEINMLKKYSHHRN 106
Query: 595 VVRYYNAWIESTTEPID 611
+ YY A+I+ +D
Sbjct: 107 IATYYGAFIKKNPPGMD 123
>U77129-1|AAB48435.1| 846|Homo sapiens KHS1 protein.
Length = 846
Score = 70.5 bits (165), Expect = 4e-11
Identities = 59/205 (28%), Positives = 94/205 (45%), Gaps = 18/205 (8%)
Query: 713 KQVLYIQMEFCEKHTLRQAID-NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVN 771
++ L+I ME+C +L+ G E A+ + RE ++GLA++H +G +HRD+K N
Sbjct: 87 REKLWICMEYCGGGSLQDIYHVTGPLSELQIAY-VCRETLQGLAYLHTKGKMHRDIKGAN 145
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
I L + VK+ DFG+A K + K++ IGT ++APE+
Sbjct: 146 ILLTDHGDVKLADFGVAAKITATI-----AKRKSF-------IGTPYWMAPEVAAVEKNG 193
Query: 832 IYNQKVDIYSLGIILFEM--FHPPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIH- 888
YNQ DI+++GI E+ PP+ + M L + + P D + H
Sbjct: 194 GYNQLCDIWAVGITAIELGELQPPM-FDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHN 252
Query: 889 VIRWLLNHEASLRPTCAELLASEHV 913
++ L RPT LL V
Sbjct: 253 FVKIALTKNPKKRPTAERLLTHTFV 277
Score = 41.5 bits (93), Expect = 0.023
Identities = 20/70 (28%), Positives = 40/70 (57%), Gaps = 4/70 (5%)
Query: 535 EFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNP-ESVQLNKKITREVKLLSRLNHE 593
++E++ +G G +GDV K +N G A+K ++L P + L I +E+ ++ H
Sbjct: 19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSL---IQQEIFMVKECKHC 75
Query: 594 NVVRYYNAWI 603
N+V Y+ +++
Sbjct: 76 NIVAYFGSYL 85
Score = 38.7 bits (86), Expect = 0.16
Identities = 35/149 (23%), Positives = 61/149 (40%), Gaps = 20/149 (13%)
Query: 259 SSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSNASLIPY 318
S T Y A + TGE K + P DF IQQ++ + + +++ Y
Sbjct: 28 SGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSL-------IQQEIFMVKECKHCNIVAY 80
Query: 319 VAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSA 378
+ S++ ++I + G SL+++ S+ + +V L
Sbjct: 81 FGSYL--------SREKLWICMEYCGGGSLQDIYHVTGPLSEL-----QIAYVCRETLQG 127
Query: 379 LNELHAANIIHRDVRSENVFVDDVGQVKL 407
L LH +HRD++ N+ + D G VKL
Sbjct: 128 LAYLHTKGKMHRDIKGANILLTDHGDVKL 156
>BC070077-1|AAH70077.1| 968|Homo sapiens serine/threonine kinase 10
protein.
Length = 968
Score = 70.5 bits (165), Expect = 4e-11
Identities = 57/202 (28%), Positives = 95/202 (47%), Gaps = 27/202 (13%)
Query: 716 LYIQMEFCEK---HTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
L+I +EFC + +D GL + + + R+++E L +H + +IHRDLK N+
Sbjct: 106 LWIMIEFCPGGAVDAIMLELDRGLTEPQIQ--EVCRQMLEALNFLHSKRIIHRDLKAGNV 163
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSAT--K 830
+ +++ DFG++ K L D IGT ++APE++ T
Sbjct: 164 LMTLEGDIRLADFGVSAKNLKTLQKRDSF------------IGTPYWMAPEVVMCETMKD 211
Query: 831 VIYNQKVDIYSLGIILFEMFH-PPLETGMERMMVLTNLRSKD---IVIPNKFDVDENVKQ 886
Y+ K DI+SLGI L EM P + M VL + D ++ P+K+ V+
Sbjct: 212 TPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFR--- 268
Query: 887 IHVIRWLLNHEASLRPTCAELL 908
++ L+ RP+ A+LL
Sbjct: 269 -DFLKIALDKNPETRPSAAQLL 289
Score = 41.5 bits (93), Expect = 0.023
Identities = 23/67 (34%), Positives = 37/67 (55%), Gaps = 2/67 (2%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENV 595
+E++ LG GAFG V K KNK G A K ++ E +L I E+++L+ +H +
Sbjct: 36 WEIVGELGDGAFGKVYKAKNKETGALVAAKVIETKSEE-ELEDYIV-EIEILATCDHPYI 93
Query: 596 VRYYNAW 602
V+ A+
Sbjct: 94 VKLLGAY 100
Score = 35.9 bits (79), Expect = 1.2
Identities = 16/40 (40%), Positives = 26/40 (65%)
Query: 368 LRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKL 407
++ V +L ALN LH+ IIHRD+++ NV + G ++L
Sbjct: 134 IQEVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRL 173
>BC036013-1|AAH36013.1| 846|Homo sapiens mitogen-activated protein
kinase kinase kinase kinase 5 protein.
Length = 846
Score = 70.5 bits (165), Expect = 4e-11
Identities = 59/205 (28%), Positives = 94/205 (45%), Gaps = 18/205 (8%)
Query: 713 KQVLYIQMEFCEKHTLRQAID-NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVN 771
++ L+I ME+C +L+ G E A+ + RE ++GLA++H +G +HRD+K N
Sbjct: 87 REKLWICMEYCGGGSLQDIYHVTGPLSELQIAY-VCRETLQGLAYLHTKGKMHRDIKGAN 145
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
I L + VK+ DFG+A K + K++ IGT ++APE+
Sbjct: 146 ILLTDHGDVKLADFGVAAKITATI-----AKRKSF-------IGTPYWMAPEVAAVEKNG 193
Query: 832 IYNQKVDIYSLGIILFEM--FHPPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIH- 888
YNQ DI+++GI E+ PP+ + M L + + P D + H
Sbjct: 194 GYNQLCDIWAVGITAIELGELQPPM-FDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHN 252
Query: 889 VIRWLLNHEASLRPTCAELLASEHV 913
++ L RPT LL V
Sbjct: 253 FVKIALTKNPKKRPTAERLLTHTFV 277
Score = 41.5 bits (93), Expect = 0.023
Identities = 20/70 (28%), Positives = 40/70 (57%), Gaps = 4/70 (5%)
Query: 535 EFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNP-ESVQLNKKITREVKLLSRLNHE 593
++E++ +G G +GDV K +N G A+K ++L P + L I +E+ ++ H
Sbjct: 19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSL---IQQEIFMVKECKHC 75
Query: 594 NVVRYYNAWI 603
N+V Y+ +++
Sbjct: 76 NIVAYFGSYL 85
Score = 38.7 bits (86), Expect = 0.16
Identities = 35/149 (23%), Positives = 61/149 (40%), Gaps = 20/149 (13%)
Query: 259 SSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSNASLIPY 318
S T Y A + TGE K + P DF IQQ++ + + +++ Y
Sbjct: 28 SGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSL-------IQQEIFMVKECKHCNIVAY 80
Query: 319 VAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSA 378
+ S++ ++I + G SL+++ S+ + +V L
Sbjct: 81 FGSYL--------SREKLWICMEYCGGGSLQDIYHVTGPLSEL-----QIAYVCRETLQG 127
Query: 379 LNELHAANIIHRDVRSENVFVDDVGQVKL 407
L LH +HRD++ N+ + D G VKL
Sbjct: 128 LAYLHTKGKMHRDIKGANILLTDHGDVKL 156
>AK000556-1|BAA91251.1| 293|Homo sapiens protein ( Homo sapiens
cDNA FLJ20549 fis, clone KAT11561. ).
Length = 293
Score = 70.5 bits (165), Expect = 4e-11
Identities = 54/169 (31%), Positives = 84/169 (49%), Gaps = 19/169 (11%)
Query: 746 LFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEE 805
+ +EI++GL ++H IHRD+K N+ L VK+ DFG+A G + + K+
Sbjct: 1 MLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVA-----GQLTDTQIKRNT 55
Query: 806 IGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH-PPLETGMERMMVL 864
+GT ++APE++Q + Y+ K DI+SLGI E+ P + M M VL
Sbjct: 56 F-------VGTPFWMAPEVIQQSA---YDSKADIWSLGITAIELAKGEPPNSDMHPMRVL 105
Query: 865 TNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEHV 913
L K+ D ++ K+ I LN + S RPT ELL + +
Sbjct: 106 F-LIPKNNPPTLVGDFTKSFKEF--IDACLNKDPSFRPTAKELLKHKFI 151
Score = 35.5 bits (78), Expect = 1.5
Identities = 15/44 (34%), Positives = 26/44 (59%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAE 418
+L L+ LH+ IHRD+++ NV + + G VKL + +L +
Sbjct: 5 ILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTD 48
Score = 33.5 bits (73), Expect = 6.2
Identities = 14/37 (37%), Positives = 23/37 (62%)
Query: 464 KDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTKKPYV 500
K+FI CL +D + +AK+L+ H F+V+ K Y+
Sbjct: 125 KEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYL 161
>AB015718-1|BAA35073.1| 968|Homo sapiens protein kinase protein.
Length = 968
Score = 70.5 bits (165), Expect = 4e-11
Identities = 57/202 (28%), Positives = 95/202 (47%), Gaps = 27/202 (13%)
Query: 716 LYIQMEFCEK---HTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
L+I +EFC + +D GL + + + R+++E L +H + +IHRDLK N+
Sbjct: 106 LWIMIEFCPGGAVDAIMLELDRGLTEPQIQV--VCRQMLEALNFLHSKRIIHRDLKAGNV 163
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSAT--K 830
+ +++ DFG++ K L D IGT ++APE++ T
Sbjct: 164 LMTLEGDIRLADFGVSAKNLKTLQKRDSF------------IGTPYWMAPEVVMCETMKD 211
Query: 831 VIYNQKVDIYSLGIILFEMFH-PPLETGMERMMVLTNLRSKD---IVIPNKFDVDENVKQ 886
Y+ K DI+SLGI L EM P + M VL + D ++ P+K+ V+
Sbjct: 212 TPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFR--- 268
Query: 887 IHVIRWLLNHEASLRPTCAELL 908
++ L+ RP+ A+LL
Sbjct: 269 -DFLKIALDKNPETRPSAAQLL 289
Score = 41.1 bits (92), Expect = 0.031
Identities = 23/67 (34%), Positives = 37/67 (55%), Gaps = 2/67 (2%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENV 595
+E++ LG GAFG V K KNK G A K ++ E +L I E+++L+ +H +
Sbjct: 36 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEE-ELEDYIV-EIEILATCDHPYI 93
Query: 596 VRYYNAW 602
V+ A+
Sbjct: 94 VKLLGAY 100
Score = 34.7 bits (76), Expect = 2.7
Identities = 15/33 (45%), Positives = 23/33 (69%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKL 407
+L ALN LH+ IIHRD+++ NV + G ++L
Sbjct: 141 MLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRL 173
>U64205-1|AAC15093.1| 729|Homo sapiens Cdc25C associated protein
kinase C-TAK1 protein.
Length = 729
Score = 70.1 bits (164), Expect = 6e-11
Identities = 46/138 (33%), Positives = 74/138 (53%), Gaps = 17/138 (12%)
Query: 713 KQVLYIQMEFCEK-HTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVN 771
++ LY+ ME+ + +G +E A FR+IV + + HQ+ ++HRDLK N
Sbjct: 125 EKTLYLIMEYASGGEVFDYLVAHGRMKEK-EARSKFRQIVSAVQYCHQKRIVHRDLKAEN 183
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
+ LD++ ++KI DFG + + FT +GG L G+ Y APEL Q K
Sbjct: 184 LLLDADMNIKIADFGFSNE-FT------------VGGKLDTFCGSPPYAAPELFQG--KK 228
Query: 832 IYNQKVDIYSLGIILFEM 849
+VD++SLG+IL+ +
Sbjct: 229 YDGPEVDVWSLGVILYTL 246
Score = 45.2 bits (102), Expect = 0.002
Identities = 26/67 (38%), Positives = 40/67 (59%), Gaps = 6/67 (8%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIK---RVQLNPESVQLNKKITREVKLLSRLNH 592
+ +L +GKG F V ++ L G AIK + QLNP S+Q K+ REV+++ LNH
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ---KLFREVRIMKILNH 112
Query: 593 ENVVRYY 599
N+V+ +
Sbjct: 113 PNIVKLF 119
>L07861-1|AAA03175.1| 676|Homo sapiens protein kinase C-delta 13
protein.
Length = 676
Score = 70.1 bits (164), Expect = 6e-11
Identities = 52/139 (37%), Positives = 71/139 (51%), Gaps = 19/139 (13%)
Query: 713 KQVLYIQMEFCEKHTLRQAI-DNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVN 771
K L+ MEF L I D G F E +RA EI+ GL +H +G+I+RDLK N
Sbjct: 420 KDHLFFVMEFLNGGDLMYHIQDKGRF-ELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDN 478
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQI-GTALYVAPELLQSATK 830
+ LD + H+KI DFG+ K+ G S GT Y+APE+LQ
Sbjct: 479 VLLDRDGHIKIADFGMC-------------KENIFGESRASTFCGTPDYIAPEILQG--- 522
Query: 831 VIYNQKVDIYSLGIILFEM 849
+ Y VD +S G++L+EM
Sbjct: 523 LKYTFSVDWWSFGVLLYEM 541
>L07860-1|AAA03176.1| 676|Homo sapiens protein kinase C-delta 13
protein.
Length = 676
Score = 70.1 bits (164), Expect = 6e-11
Identities = 52/139 (37%), Positives = 71/139 (51%), Gaps = 19/139 (13%)
Query: 713 KQVLYIQMEFCEKHTLRQAI-DNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVN 771
K L+ MEF L I D G F E +RA EI+ GL +H +G+I+RDLK N
Sbjct: 420 KDHLFFVMEFLNGGDLMYHIQDKGRF-ELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDN 478
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQI-GTALYVAPELLQSATK 830
+ LD + H+KI DFG+ K+ G S GT Y+APE+LQ
Sbjct: 479 VLLDRDGHIKIADFGMC-------------KENIFGESRASTFCGTPDYIAPEILQG--- 522
Query: 831 VIYNQKVDIYSLGIILFEM 849
+ Y VD +S G++L+EM
Sbjct: 523 LKYTFSVDWWSFGVLLYEM 541
>D10495-1|BAA01381.1| 626|Homo sapiens protein kinase C delta-type
protein.
Length = 626
Score = 70.1 bits (164), Expect = 6e-11
Identities = 52/139 (37%), Positives = 71/139 (51%), Gaps = 19/139 (13%)
Query: 713 KQVLYIQMEFCEKHTLRQAI-DNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVN 771
K L+ MEF L I D G F E +RA EI+ GL +H +G+I+RDLK N
Sbjct: 370 KDHLFFVMEFLNGGDLMYHIQDKGRF-ELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDN 428
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQI-GTALYVAPELLQSATK 830
+ LD + H+KI DFG+ K+ G S GT Y+APE+LQ
Sbjct: 429 VLLDRDGHIKIADFGMC-------------KENIFGESRASTFCGTPDYIAPEILQG--- 472
Query: 831 VIYNQKVDIYSLGIILFEM 849
+ Y VD +S G++L+EM
Sbjct: 473 LKYTFSVDWWSFGVLLYEM 491
>BC043350-1|AAH43350.1| 676|Homo sapiens protein kinase C, delta
protein.
Length = 676
Score = 70.1 bits (164), Expect = 6e-11
Identities = 52/139 (37%), Positives = 71/139 (51%), Gaps = 19/139 (13%)
Query: 713 KQVLYIQMEFCEKHTLRQAI-DNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVN 771
K L+ MEF L I D G F E +RA EI+ GL +H +G+I+RDLK N
Sbjct: 420 KDHLFFVMEFLNGGDLMYHIQDKGRF-ELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDN 478
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQI-GTALYVAPELLQSATK 830
+ LD + H+KI DFG+ K+ G S GT Y+APE+LQ
Sbjct: 479 VLLDRDGHIKIADFGMC-------------KENIFGESRASTFCGTPDYIAPEILQG--- 522
Query: 831 VIYNQKVDIYSLGIILFEM 849
+ Y VD +S G++L+EM
Sbjct: 523 LKYTFSVDWWSFGVLLYEM 541
>BC024773-1|AAH24773.1| 729|Homo sapiens MAP/microtubule
affinity-regulating kinase 3 protein.
Length = 729
Score = 70.1 bits (164), Expect = 6e-11
Identities = 46/138 (33%), Positives = 74/138 (53%), Gaps = 17/138 (12%)
Query: 713 KQVLYIQMEFCEK-HTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVN 771
++ LY+ ME+ + +G +E A FR+IV + + HQ+ ++HRDLK N
Sbjct: 125 EKTLYLIMEYASGGEVFDYLVAHGRMKEK-EARSKFRQIVSAVQYCHQKRIVHRDLKAEN 183
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
+ LD++ ++KI DFG + + FT +GG L G+ Y APEL Q K
Sbjct: 184 LLLDADMNIKIADFGFSNE-FT------------VGGKLDTFCGSPPYAAPELFQG--KK 228
Query: 832 IYNQKVDIYSLGIILFEM 849
+VD++SLG+IL+ +
Sbjct: 229 YDGPEVDVWSLGVILYTL 246
Score = 45.2 bits (102), Expect = 0.002
Identities = 26/67 (38%), Positives = 40/67 (59%), Gaps = 6/67 (8%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIK---RVQLNPESVQLNKKITREVKLLSRLNH 592
+ +L +GKG F V ++ L G AIK + QLNP S+Q K+ REV+++ LNH
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ---KLFREVRIMKILNH 112
Query: 593 ENVVRYY 599
N+V+ +
Sbjct: 113 PNIVKLF 119
>AL022329-1|CAB45657.1| 688|Homo sapiens adrenergic, beta, receptor
kinase 2 protein.
Length = 688
Score = 70.1 bits (164), Expect = 6e-11
Identities = 56/173 (32%), Positives = 86/173 (49%), Gaps = 28/173 (16%)
Query: 734 NGLFQEHFRAWRLFR-EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAF 792
+G+F E + R + EI+ GL H+H R +++RDLKP NI LD + H +I D GLA
Sbjct: 286 HGVFSE--KEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLAC--- 340
Query: 793 TGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMF-- 850
D +K++ +GT Y+APE+LQ T Y+ D +SLG +LF++
Sbjct: 341 ------DFSKKKP-----HASVGTHGYMAPEVLQKGT--AYDSSADWFSLGCMLFKLLRG 387
Query: 851 HPPL-------ETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNH 896
H P + ++RM + N+ D P + E + Q V + L H
Sbjct: 388 HSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCH 440
>AK098832-1|BAC05427.1| 404|Homo sapiens protein ( Homo sapiens
cDNA FLJ25966 fis, clone TST05207. ).
Length = 404
Score = 70.1 bits (164), Expect = 6e-11
Identities = 39/109 (35%), Positives = 62/109 (56%), Gaps = 17/109 (15%)
Query: 742 RAWRLFREIVEGLAHVH-QRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDK 800
R W++F ++ L ++H ++ ++HRDL P NI L D V + DFGLA
Sbjct: 27 RLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLA------------ 74
Query: 801 TKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEM 849
KQ++ LT +GT LY PE+L+S Y +K D++++G IL++M
Sbjct: 75 -KQKQENSKLTSVVGTILYSCPEVLKSEP---YGEKADVWAVGCILYQM 119
>AF387637-1|AAK82367.1| 744|Homo sapiens Ser/Thr protein kinase
PAR-1A protein.
Length = 744
Score = 70.1 bits (164), Expect = 6e-11
Identities = 46/138 (33%), Positives = 74/138 (53%), Gaps = 17/138 (12%)
Query: 713 KQVLYIQMEFCEK-HTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVN 771
++ LY+ ME+ + +G +E A FR+IV + + HQ+ ++HRDLK N
Sbjct: 125 EKTLYLIMEYASGGEVFDYLVAHGRMKEK-EARSKFRQIVSAVQYCHQKRIVHRDLKAEN 183
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
+ LD++ ++KI DFG + + FT +GG L G+ Y APEL Q K
Sbjct: 184 LLLDADMNIKIADFGFSNE-FT------------VGGKLDTFCGSPPYAAPELFQG--KK 228
Query: 832 IYNQKVDIYSLGIILFEM 849
+VD++SLG+IL+ +
Sbjct: 229 YDGPEVDVWSLGVILYTL 246
Score = 45.2 bits (102), Expect = 0.002
Identities = 26/67 (38%), Positives = 40/67 (59%), Gaps = 6/67 (8%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIK---RVQLNPESVQLNKKITREVKLLSRLNH 592
+ +L +GKG F V ++ L G AIK + QLNP S+Q K+ REV+++ LNH
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ---KLFREVRIMKILNH 112
Query: 593 ENVVRYY 599
N+V+ +
Sbjct: 113 PNIVKLF 119
>X61157-1|CAA43470.1| 689|Homo sapiens beta-adrenergic receptor
kinase protein.
Length = 689
Score = 69.7 bits (163), Expect = 8e-11
Identities = 43/107 (40%), Positives = 61/107 (57%), Gaps = 18/107 (16%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
EI+ GL H+H R +++RDLKP NI LD + HV+I D GLA D +K++
Sbjct: 300 EIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC---------DFSKKKP--- 347
Query: 809 SLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMF--HPP 853
+GT Y+APE+LQ V Y+ D +SLG +LF++ H P
Sbjct: 348 --HASVGTHGYMAPEVLQKG--VAYDSSADWFSLGCMLFKLLRGHSP 390
>X59727-1|CAA42411.1| 557|Homo sapiens 63kDa protein kinase
protein.
Length = 557
Score = 69.7 bits (163), Expect = 8e-11
Identities = 50/144 (34%), Positives = 74/144 (51%), Gaps = 15/144 (10%)
Query: 708 QSERLK-QVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRD 766
Q E K V YI E+ E R L +EH + + +++ GL ++H ++HRD
Sbjct: 92 QGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMY--QLLRGLKYIHSANVLHRD 149
Query: 767 LKPVNIFLDSNDHV-KIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELL 825
LKP NIF+ + D V KIGDFGLA + D+ + G L+ + T Y +P LL
Sbjct: 150 LKPANIFISTEDLVLKIGDFGLAR-------IVDQHYSHK--GYLSEGLVTKWYRSPRLL 200
Query: 826 QSATKVIYNQKVDIYSLGIILFEM 849
S Y + +D+++ G IL EM
Sbjct: 201 LSPNN--YTKAIDMWAAGCILAEM 222
Score = 35.5 bits (78), Expect = 1.5
Identities = 23/74 (31%), Positives = 41/74 (55%), Gaps = 8/74 (10%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAEMLDNDNYCDKQTPAQD 434
+L L +H+AN++HRD++ N+F+ V +G D LA ++D +Y K ++
Sbjct: 133 LLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIG---DFGLARIVD-QHYSHKGYLSEG 188
Query: 435 I----YATGQLLLS 444
+ Y + +LLLS
Sbjct: 189 LVTKWYRSPRLLLS 202
Score = 34.3 bits (75), Expect = 3.5
Identities = 19/58 (32%), Positives = 32/58 (55%), Gaps = 2/58 (3%)
Query: 542 LGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENVVRYY 599
LG G G VL + A+K++ L+ + K RE+K++ RL+H+N+V+ Y
Sbjct: 26 LGFGVNGLVLSAVDSRACRKVAVKKIALS--DARSMKHALREIKIIRRLDHDNIVKVY 81
>U08438-1|AAB60689.1| 689|Homo sapiens beta-adrenergic receptor
kinase protein.
Length = 689
Score = 69.7 bits (163), Expect = 8e-11
Identities = 43/107 (40%), Positives = 61/107 (57%), Gaps = 18/107 (16%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
EI+ GL H+H R +++RDLKP NI LD + HV+I D GLA D +K++
Sbjct: 300 EIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC---------DFSKKKP--- 347
Query: 809 SLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMF--HPP 853
+GT Y+APE+LQ V Y+ D +SLG +LF++ H P
Sbjct: 348 --HASVGTHGYMAPEVLQKG--VAYDSSADWFSLGCMLFKLLRGHSP 390
>M80776-1|AAA58391.1| 689|Homo sapiens receptor kinase protein.
Length = 689
Score = 69.7 bits (163), Expect = 8e-11
Identities = 43/107 (40%), Positives = 61/107 (57%), Gaps = 18/107 (16%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
EI+ GL H+H R +++RDLKP NI LD + HV+I D GLA D +K++
Sbjct: 300 EIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC---------DFSKKKP--- 347
Query: 809 SLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMF--HPP 853
+GT Y+APE+LQ V Y+ D +SLG +LF++ H P
Sbjct: 348 --HASVGTHGYMAPEVLQKG--VAYDSSADWFSLGCMLFKLLRGHSP 390
>M80359-1|AAA59991.1| 713|Homo sapiens protein p78 protein.
Length = 713
Score = 69.7 bits (163), Expect = 8e-11
Identities = 46/138 (33%), Positives = 74/138 (53%), Gaps = 17/138 (12%)
Query: 713 KQVLYIQMEFCEK-HTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVN 771
++ LY+ ME+ + +G +E A FR+IV + + HQ+ ++HRDLK N
Sbjct: 125 QKTLYLIMEYASGGKVFDYLVAHGRMKEK-EARSKFRQIVSAVQYCHQKRIVHRDLKAEN 183
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
+ LD++ ++KI DFG + + FT +GG L G+ Y APEL Q K
Sbjct: 184 LLLDADMNIKIADFGFSNE-FT------------VGGKLDTFCGSPPYAAPELFQG--KK 228
Query: 832 IYNQKVDIYSLGIILFEM 849
+VD++SLG+IL+ +
Sbjct: 229 YDGPEVDVWSLGVILYTL 246
Score = 45.2 bits (102), Expect = 0.002
Identities = 26/67 (38%), Positives = 40/67 (59%), Gaps = 6/67 (8%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIK---RVQLNPESVQLNKKITREVKLLSRLNH 592
+ +L +GKG F V ++ L G AIK + QLNP S+Q K+ REV+++ LNH
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ---KLFREVRIMKILNH 112
Query: 593 ENVVRYY 599
N+V+ +
Sbjct: 113 PNIVKLF 119
>BC117216-1|AAI17217.1| 587|Homo sapiens mitogen-activated protein
kinase 4 protein.
Length = 587
Score = 69.7 bits (163), Expect = 8e-11
Identities = 50/144 (34%), Positives = 74/144 (51%), Gaps = 15/144 (10%)
Query: 708 QSERLK-QVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRD 766
Q E K V YI E+ E R L +EH + + +++ GL ++H ++HRD
Sbjct: 92 QGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMY--QLLRGLKYIHSANVLHRD 149
Query: 767 LKPVNIFLDSNDHV-KIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELL 825
LKP NIF+ + D V KIGDFGLA + D+ + G L+ + T Y +P LL
Sbjct: 150 LKPANIFISTEDLVLKIGDFGLAR-------IVDQHYSHK--GYLSEGLVTKWYRSPRLL 200
Query: 826 QSATKVIYNQKVDIYSLGIILFEM 849
S Y + +D+++ G IL EM
Sbjct: 201 LSPNN--YTKAIDMWAAGCILAEM 222
Score = 35.5 bits (78), Expect = 1.5
Identities = 23/74 (31%), Positives = 41/74 (55%), Gaps = 8/74 (10%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAEMLDNDNYCDKQTPAQD 434
+L L +H+AN++HRD++ N+F+ V +G D LA ++D +Y K ++
Sbjct: 133 LLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIG---DFGLARIVD-QHYSHKGYLSEG 188
Query: 435 I----YATGQLLLS 444
+ Y + +LLLS
Sbjct: 189 LVTKWYRSPRLLLS 202
Score = 34.3 bits (75), Expect = 3.5
Identities = 19/58 (32%), Positives = 32/58 (55%), Gaps = 2/58 (3%)
Query: 542 LGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENVVRYY 599
LG G G VL + A+K++ L+ + K RE+K++ RL+H+N+V+ Y
Sbjct: 26 LGFGVNGLVLSAVDSRACRKVAVKKIALS--DARSMKHALREIKIIRRLDHDNIVKVY 81
>BC090863-1|AAH90863.1| 689|Homo sapiens ADRBK1 protein protein.
Length = 689
Score = 69.7 bits (163), Expect = 8e-11
Identities = 43/107 (40%), Positives = 61/107 (57%), Gaps = 18/107 (16%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
EI+ GL H+H R +++RDLKP NI LD + HV+I D GLA D +K++
Sbjct: 300 EIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC---------DFSKKKP--- 347
Query: 809 SLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMF--HPP 853
+GT Y+APE+LQ V Y+ D +SLG +LF++ H P
Sbjct: 348 --HASVGTHGYMAPEVLQKG--VAYDSSADWFSLGCMLFKLLRGHSP 390
>BC050299-1|AAH50299.1| 587|Homo sapiens mitogen-activated protein
kinase 4 protein.
Length = 587
Score = 69.7 bits (163), Expect = 8e-11
Identities = 50/144 (34%), Positives = 74/144 (51%), Gaps = 15/144 (10%)
Query: 708 QSERLK-QVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRD 766
Q E K V YI E+ E R L +EH + + +++ GL ++H ++HRD
Sbjct: 92 QGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMY--QLLRGLKYIHSANVLHRD 149
Query: 767 LKPVNIFLDSNDHV-KIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELL 825
LKP NIF+ + D V KIGDFGLA + D+ + G L+ + T Y +P LL
Sbjct: 150 LKPANIFISTEDLVLKIGDFGLAR-------IVDQHYSHK--GYLSEGLVTKWYRSPRLL 200
Query: 826 QSATKVIYNQKVDIYSLGIILFEM 849
S Y + +D+++ G IL EM
Sbjct: 201 LSPNN--YTKAIDMWAAGCILSEM 222
Score = 35.5 bits (78), Expect = 1.5
Identities = 23/74 (31%), Positives = 41/74 (55%), Gaps = 8/74 (10%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAEMLDNDNYCDKQTPAQD 434
+L L +H+AN++HRD++ N+F+ V +G D LA ++D +Y K ++
Sbjct: 133 LLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIG---DFGLARIVD-QHYSHKGYLSEG 188
Query: 435 I----YATGQLLLS 444
+ Y + +LLLS
Sbjct: 189 LVTKWYRSPRLLLS 202
Score = 34.7 bits (76), Expect = 2.7
Identities = 19/58 (32%), Positives = 32/58 (55%), Gaps = 2/58 (3%)
Query: 542 LGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENVVRYY 599
LG G G VL + A+K++ L+ + K RE+K++ RL+H+N+V+ Y
Sbjct: 26 LGFGVNGLVLSAMDSRACRKVAVKKIALS--DARSMKHALREIKIIRRLDHDNIVKVY 81
>BC037963-1|AAH37963.1| 689|Homo sapiens adrenergic, beta, receptor
kinase 1 protein.
Length = 689
Score = 69.7 bits (163), Expect = 8e-11
Identities = 43/107 (40%), Positives = 61/107 (57%), Gaps = 18/107 (16%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
EI+ GL H+H R +++RDLKP NI LD + HV+I D GLA D +K++
Sbjct: 300 EIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC---------DFSKKKP--- 347
Query: 809 SLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMF--HPP 853
+GT Y+APE+LQ V Y+ D +SLG +LF++ H P
Sbjct: 348 --HASVGTHGYMAPEVLQKG--VAYDSSADWFSLGCMLFKLLRGHSP 390
>AY120867-1|AAM55491.1| 752|Homo sapiens MAP/microtubule
affinity-regulating kinase-like 1 protein.
Length = 752
Score = 69.7 bits (163), Expect = 8e-11
Identities = 46/138 (33%), Positives = 72/138 (52%), Gaps = 17/138 (12%)
Query: 713 KQVLYIQMEFCEK-HTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVN 771
++ LY+ ME+ + +G +E A FR+IV + + HQ+ ++HRDLK N
Sbjct: 128 EKTLYLVMEYASAGEVFDYLVSHGRMKEK-EARAKFRQIVSAVHYCHQKNIVHRDLKAEN 186
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
+ LD+ ++KI DFG + + FT +G L G+ Y APEL Q K
Sbjct: 187 LLLDAEANIKIADFGFSNE-FT------------LGSKLDTFCGSPPYAAPELFQG--KK 231
Query: 832 IYNQKVDIYSLGIILFEM 849
+VDI+SLG+IL+ +
Sbjct: 232 YDGPEVDIWSLGVILYTL 249
Score = 46.0 bits (104), Expect = 0.001
Identities = 26/67 (38%), Positives = 40/67 (59%), Gaps = 6/67 (8%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIK---RVQLNPESVQLNKKITREVKLLSRLNH 592
+ +L +GKG F V ++ L G AIK + QLNP S+Q K+ REV+++ LNH
Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQ---KLFREVRIMKGLNH 115
Query: 593 ENVVRYY 599
N+V+ +
Sbjct: 116 PNIVKLF 122
Score = 37.1 bits (82), Expect = 0.50
Identities = 17/49 (34%), Positives = 30/49 (61%), Gaps = 2/49 (4%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLV--GASLDTRLAEMLD 421
++SA++ H NI+HRD+++EN+ +D +K+ G S + L LD
Sbjct: 165 IVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLD 213
>AY057448-1|AAL23683.1| 752|Homo sapiens MARK4 serine/threonine
protein kinase protein.
Length = 752
Score = 69.7 bits (163), Expect = 8e-11
Identities = 46/138 (33%), Positives = 72/138 (52%), Gaps = 17/138 (12%)
Query: 713 KQVLYIQMEFCEK-HTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVN 771
++ LY+ ME+ + +G +E A FR+IV + + HQ+ ++HRDLK N
Sbjct: 128 EKTLYLVMEYASAGEVFDYLVSHGRMKEK-EARAKFRQIVSAVHYCHQKNIVHRDLKAEN 186
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
+ LD+ ++KI DFG + + FT +G L G+ Y APEL Q K
Sbjct: 187 LLLDAEANIKIADFGFSNE-FT------------LGSKLDTFCGSPPYAAPELFQG--KK 231
Query: 832 IYNQKVDIYSLGIILFEM 849
+VDI+SLG+IL+ +
Sbjct: 232 YDGPEVDIWSLGVILYTL 249
Score = 46.0 bits (104), Expect = 0.001
Identities = 26/67 (38%), Positives = 40/67 (59%), Gaps = 6/67 (8%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIK---RVQLNPESVQLNKKITREVKLLSRLNH 592
+ +L +GKG F V ++ L G AIK + QLNP S+Q K+ REV+++ LNH
Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQ---KLFREVRIMKGLNH 115
Query: 593 ENVVRYY 599
N+V+ +
Sbjct: 116 PNIVKLF 122
Score = 37.1 bits (82), Expect = 0.50
Identities = 17/49 (34%), Positives = 30/49 (61%), Gaps = 2/49 (4%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLV--GASLDTRLAEMLD 421
++SA++ H NI+HRD+++EN+ +D +K+ G S + L LD
Sbjct: 165 IVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLD 213
>AK075272-1|BAC11510.1| 752|Homo sapiens protein ( Homo sapiens
cDNA FLJ90791 fis, clone THYRO1001593, moderately
similar to PUTATIVE SERINE/THREONINE-PROTEIN KINASE P78
(EC 2.7.1.-). ).
Length = 752
Score = 69.7 bits (163), Expect = 8e-11
Identities = 46/138 (33%), Positives = 72/138 (52%), Gaps = 17/138 (12%)
Query: 713 KQVLYIQMEFCEK-HTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVN 771
++ LY+ ME+ + +G +E A FR+IV + + HQ+ ++HRDLK N
Sbjct: 128 EKTLYLVMEYASAGEVFDYLVSHGRMKEK-EARAKFRQIVSAVHYCHQKNIVHRDLKAEN 186
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
+ LD+ ++KI DFG + + FT +G L G+ Y APEL Q K
Sbjct: 187 LLLDAEANIKIADFGFSNE-FT------------LGSKLDTFCGSPPYAAPELFQG--KK 231
Query: 832 IYNQKVDIYSLGIILFEM 849
+VDI+SLG+IL+ +
Sbjct: 232 YDGPEVDIWSLGVILYTL 249
Score = 46.0 bits (104), Expect = 0.001
Identities = 26/67 (38%), Positives = 40/67 (59%), Gaps = 6/67 (8%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIK---RVQLNPESVQLNKKITREVKLLSRLNH 592
+ +L +GKG F V ++ L G AIK + QLNP S+Q K+ REV+++ LNH
Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQ---KLFREVRIMKGLNH 115
Query: 593 ENVVRYY 599
N+V+ +
Sbjct: 116 PNIVKLF 122
Score = 37.1 bits (82), Expect = 0.50
Identities = 17/49 (34%), Positives = 30/49 (61%), Gaps = 2/49 (4%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLV--GASLDTRLAEMLD 421
++SA++ H NI+HRD+++EN+ +D +K+ G S + L LD
Sbjct: 165 IVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLD 213
>AF465413-1|AAL69982.1| 753|Homo sapiens MAP/microtubule
affinity-regulating kinase 3 long isoform protein.
Length = 753
Score = 69.7 bits (163), Expect = 8e-11
Identities = 46/138 (33%), Positives = 74/138 (53%), Gaps = 17/138 (12%)
Query: 713 KQVLYIQMEFCEK-HTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVN 771
++ LY+ ME+ + +G +E A FR+IV + + HQ+ ++HRDLK N
Sbjct: 125 EKTLYLIMEYASGGKVFDYLVAHGRMKEK-EARSKFRQIVSAVQYCHQKRIVHRDLKAEN 183
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
+ LD++ ++KI DFG + + FT +GG L G+ Y APEL Q K
Sbjct: 184 LLLDADMNIKIADFGFSNE-FT------------VGGKLDTFCGSPPYAAPELFQG--KK 228
Query: 832 IYNQKVDIYSLGIILFEM 849
+VD++SLG+IL+ +
Sbjct: 229 YDGPEVDVWSLGVILYTL 246
Score = 45.2 bits (102), Expect = 0.002
Identities = 26/67 (38%), Positives = 40/67 (59%), Gaps = 6/67 (8%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIK---RVQLNPESVQLNKKITREVKLLSRLNH 592
+ +L +GKG F V ++ L G AIK + QLNP S+Q K+ REV+++ LNH
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ---KLFREVRIMKILNH 112
Query: 593 ENVVRYY 599
N+V+ +
Sbjct: 113 PNIVKLF 119
>AF099989-1|AAC72238.1| 547|Homo sapiens Ste-20 related kinase SPAK
protein.
Length = 547
Score = 69.7 bits (163), Expect = 8e-11
Identities = 53/190 (27%), Positives = 92/190 (48%), Gaps = 17/190 (8%)
Query: 734 NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFT 793
NG+ +E A + +E++EGL ++H+ G IHRDLK NI L + V+I DFG++ T
Sbjct: 163 NGVLEEAIIA-TILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLAT 221
Query: 794 GLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMF--H 851
G V ++ +GT ++APE+++ Y+ K D++S GI E+
Sbjct: 222 GGDVTRNKVRKTF-------VGTPCWMAPEVMEQVRG--YDFKADMWSFGITAIELATGA 272
Query: 852 PPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQI-----HVIRWLLNHEASLRPTCAE 906
P +++ L++ + + E +K+ ++ L + S RPT AE
Sbjct: 273 APYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAE 332
Query: 907 LLASEHVPRA 916
LL + +A
Sbjct: 333 LLKCKFFQKA 342
Score = 33.9 bits (74), Expect = 4.7
Identities = 19/68 (27%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENV 595
+E+ +G GA V K AIKR+ L +++ + +E++ +S+ +H NV
Sbjct: 65 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDE-LLKEIQAMSQCSHPNV 123
Query: 596 VRYYNAWI 603
V YY +++
Sbjct: 124 VTYYTSFV 131
>AC067940-1|AAY24032.1| 363|Homo sapiens unknown protein.
Length = 363
Score = 69.7 bits (163), Expect = 8e-11
Identities = 53/190 (27%), Positives = 92/190 (48%), Gaps = 17/190 (8%)
Query: 734 NGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFT 793
NG+ +E A + +E++EGL ++H+ G IHRDLK NI L + V+I DFG++ T
Sbjct: 161 NGVLEEAIIA-TILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLAT 219
Query: 794 GLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMF--H 851
G V ++ +GT ++APE+++ Y+ K D++S GI E+
Sbjct: 220 GGDVTRNKVRKTF-------VGTPCWMAPEVMEQVRG--YDFKADMWSFGITAIELATGA 270
Query: 852 PPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQI-----HVIRWLLNHEASLRPTCAE 906
P +++ L++ + + E +K+ ++ L + S RPT AE
Sbjct: 271 APYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAE 330
Query: 907 LLASEHVPRA 916
LL + +A
Sbjct: 331 LLKCKFFQKA 340
Score = 33.9 bits (74), Expect = 4.7
Identities = 19/68 (27%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENV 595
+E+ +G GA V K AIKR+ L +++ + +E++ +S+ +H NV
Sbjct: 63 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDE-LLKEIQAMSQCSHPNV 121
Query: 596 VRYYNAWI 603
V YY +++
Sbjct: 122 VTYYTSFV 129
>AB088047-1|BAC03375.1| 752|Homo sapiens microtubule
affinity-regulating kinase-like1 protein.
Length = 752
Score = 69.7 bits (163), Expect = 8e-11
Identities = 46/138 (33%), Positives = 72/138 (52%), Gaps = 17/138 (12%)
Query: 713 KQVLYIQMEFCEK-HTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVN 771
++ LY+ ME+ + +G +E A FR+IV + + HQ+ ++HRDLK N
Sbjct: 128 EKTLYLVMEYASAGEVFDYLVSHGRMKEK-EARAKFRQIVSAVHYCHQKNIVHRDLKAEN 186
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
+ LD+ ++KI DFG + + FT +G L G+ Y APEL Q K
Sbjct: 187 LLLDAEANIKIADFGFSNE-FT------------LGSKLDTFCGSPPYAAPELFQG--KK 231
Query: 832 IYNQKVDIYSLGIILFEM 849
+VDI+SLG+IL+ +
Sbjct: 232 YDGPEVDIWSLGVILYTL 249
Score = 42.7 bits (96), Expect = 0.010
Identities = 25/67 (37%), Positives = 39/67 (58%), Gaps = 6/67 (8%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIK---RVQLNPESVQLNKKITREVKLLSRLNH 592
+ +L +GKG V ++ L G AIK + QLNP S+Q K+ REV+++ LNH
Sbjct: 59 YRLLRTIGKGNSAKVKLARHILTGREVAIKIIDKTQLNPSSLQ---KLFREVRIMKGLNH 115
Query: 593 ENVVRYY 599
N+V+ +
Sbjct: 116 PNIVKLF 122
Score = 37.1 bits (82), Expect = 0.50
Identities = 17/49 (34%), Positives = 30/49 (61%), Gaps = 2/49 (4%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLV--GASLDTRLAEMLD 421
++SA++ H NI+HRD+++EN+ +D +K+ G S + L LD
Sbjct: 165 IVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLD 213
>AB058763-1|BAB47489.1| 689|Homo sapiens KIAA1860 protein protein.
Length = 689
Score = 69.7 bits (163), Expect = 8e-11
Identities = 46/138 (33%), Positives = 72/138 (52%), Gaps = 17/138 (12%)
Query: 713 KQVLYIQMEFCEK-HTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVN 771
++ LY+ ME+ + +G +E A FR+IV + + HQ+ ++HRDLK N
Sbjct: 129 EKTLYLVMEYASAGEVFDYLVSHGRMKEK-EARAKFRQIVSAVHYCHQKNIVHRDLKAEN 187
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
+ LD+ ++KI DFG + + FT +G L G+ Y APEL Q K
Sbjct: 188 LLLDAEANIKIADFGFSNE-FT------------LGSKLDTFCGSPPYAAPELFQG--KK 232
Query: 832 IYNQKVDIYSLGIILFEM 849
+VDI+SLG+IL+ +
Sbjct: 233 YDGPEVDIWSLGVILYTL 250
Score = 46.0 bits (104), Expect = 0.001
Identities = 26/67 (38%), Positives = 40/67 (59%), Gaps = 6/67 (8%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIK---RVQLNPESVQLNKKITREVKLLSRLNH 592
+ +L +GKG F V ++ L G AIK + QLNP S+Q K+ REV+++ LNH
Sbjct: 60 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQ---KLFREVRIMKGLNH 116
Query: 593 ENVVRYY 599
N+V+ +
Sbjct: 117 PNIVKLF 123
Score = 37.1 bits (82), Expect = 0.50
Identities = 17/49 (34%), Positives = 30/49 (61%), Gaps = 2/49 (4%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLV--GASLDTRLAEMLD 421
++SA++ H NI+HRD+++EN+ +D +K+ G S + L LD
Sbjct: 166 IVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLD 214
>AB049127-1|BAB39380.1| 688|Homo sapiens MAP/microtubule
affinity-regulating kinase like 1 protein.
Length = 688
Score = 69.7 bits (163), Expect = 8e-11
Identities = 46/138 (33%), Positives = 72/138 (52%), Gaps = 17/138 (12%)
Query: 713 KQVLYIQMEFCEK-HTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVN 771
++ LY+ ME+ + +G +E A FR+IV + + HQ+ ++HRDLK N
Sbjct: 128 EKTLYLVMEYASAGEVFDYLVSHGRMKEK-EARAKFRQIVSAVHYCHQKNIVHRDLKAEN 186
Query: 772 IFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
+ LD+ ++KI DFG + + FT +G L G+ Y APEL Q K
Sbjct: 187 LLLDAEANIKIADFGFSNE-FT------------LGSKLDTFCGSPPYAAPELFQG--KK 231
Query: 832 IYNQKVDIYSLGIILFEM 849
+VDI+SLG+IL+ +
Sbjct: 232 YDGPEVDIWSLGVILYTL 249
Score = 42.7 bits (96), Expect = 0.010
Identities = 25/67 (37%), Positives = 39/67 (58%), Gaps = 6/67 (8%)
Query: 536 FEVLAWLGKGAFGDVLKVKNKLDGGFYAIK---RVQLNPESVQLNKKITREVKLLSRLNH 592
+ +L +GKG V ++ L G AIK + QLNP S+Q K+ REV+++ LNH
Sbjct: 59 YRLLRTIGKGNSAKVKLARHILTGREVAIKIIDKTQLNPSSLQ---KLFREVRIMKGLNH 115
Query: 593 ENVVRYY 599
N+V+ +
Sbjct: 116 PNIVKLF 122
Score = 37.1 bits (82), Expect = 0.50
Identities = 17/49 (34%), Positives = 30/49 (61%), Gaps = 2/49 (4%)
Query: 375 VLSALNELHAANIIHRDVRSENVFVDDVGQVKLV--GASLDTRLAEMLD 421
++SA++ H NI+HRD+++EN+ +D +K+ G S + L LD
Sbjct: 165 IVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLD 213
>Y15056-1|CAA75341.1| 556|Homo sapiens PkB kinase protein.
Length = 556
Score = 69.3 bits (162), Expect = 1e-10
Identities = 52/161 (32%), Positives = 83/161 (51%), Gaps = 20/161 (12%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
EIV L ++H +G+IHRDLKP NI L+ + H++I DFG T + ++KQ
Sbjct: 188 EIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG------TAKVLSPESKQARANS 241
Query: 809 SLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH--PPLETGMERMMVLTN 866
+GTA YV+PELL T+ + D+++LG I++++ PP G E ++
Sbjct: 242 F----VGTAQYVSPELL---TEKSACKSSDLWALGCIIYQLVAGLPPFRAGNE-YLIFQK 293
Query: 867 LRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAEL 907
+ + P KF K ++ LL +A+ R C E+
Sbjct: 294 IIKLEYDFPEKF----FPKARDLVEKLLVLDATKRLGCEEM 330
Score = 38.3 bits (85), Expect = 0.22
Identities = 29/116 (25%), Positives = 52/116 (44%), Gaps = 12/116 (10%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
+Y S+ L ++K+ F + R ++SAL LH IIHRD++ E
Sbjct: 155 LYFGLSYAKNGELLKYIRKIGSFDET-----CTRFYTAEIVSALEYLHGKGIIHRDLKPE 209
Query: 396 NVFVDDVGQVKLVGASLDTRLAEMLDNDNYCDKQTPAQDIYATGQLLLSIVCKEKS 451
N+ +++ +++ D A++L ++ KQ A T Q + + EKS
Sbjct: 210 NILLNEDMHIQIT----DFGTAKVLSPES---KQARANSFVGTAQYVSPELLTEKS 258
>U59305-1|AAB37126.1| 496|Homo sapiens ser-thr protein kinase PK428
protein.
Length = 496
Score = 69.3 bits (162), Expect = 1e-10
Identities = 47/145 (32%), Positives = 74/145 (51%), Gaps = 17/145 (11%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
E+V + VHQ +HRD+KP NI +D N H+++ DFG K +ED T Q +
Sbjct: 184 EMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKL-----MEDGTVQSSVA- 237
Query: 809 SLTGQIGTALYVAPELLQSAT--KVIYNQKVDIYSLGIILFEMFH--PPL--ETGMERMM 862
+GT Y++PE+LQ+ K Y + D +SLG+ ++EM + P E+ +E
Sbjct: 238 -----VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYG 292
Query: 863 VLTNLRSKDIVIPNKFDVDENVKQI 887
+ N + + DV EN K +
Sbjct: 293 KIMNHKERFQFPAQVTDVSENAKDL 317
Score = 34.3 bits (75), Expect = 3.5
Identities = 20/83 (24%), Positives = 42/83 (50%), Gaps = 4/83 (4%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
+Y+ + +G L L+ K F D ++A+ V+ A++ +H + +HRD++ +
Sbjct: 150 LYLVMDYYVGGDLLTLLSK---FEDRLPEDMARFYLAEMVI-AIDSVHQLHYVHRDIKPD 205
Query: 396 NVFVDDVGQVKLVGASLDTRLAE 418
N+ +D G ++L +L E
Sbjct: 206 NILMDMNGHIRLADFGSCLKLME 228
>L07032-1|AAA60101.1| 706|Homo sapiens protein kinase C-theta
protein.
Length = 706
Score = 69.3 bits (162), Expect = 1e-10
Identities = 47/138 (34%), Positives = 70/138 (50%), Gaps = 17/138 (12%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
K+ L+ ME+ L I + + RA EI+ GL +H +G+++RDLK NI
Sbjct: 451 KENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNI 510
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQI-GTALYVAPELLQSATKV 831
LD + H+KI DFG+ K+ +G + T GT Y+APE+L
Sbjct: 511 LLDKDGHIKIADFGMC-------------KENMLGDAKTNTFCGTPDYIAPEILLGQK-- 555
Query: 832 IYNQKVDIYSLGIILFEM 849
YN VD +S G++L+EM
Sbjct: 556 -YNHSVDWWSFGVLLYEM 572
>L01087-1|AAA75571.1| 706|Homo sapiens protein kinase C-theta
protein.
Length = 706
Score = 69.3 bits (162), Expect = 1e-10
Identities = 47/138 (34%), Positives = 70/138 (50%), Gaps = 17/138 (12%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
K+ L+ ME+ L I + + RA EI+ GL +H +G+++RDLK NI
Sbjct: 451 KENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNI 510
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQI-GTALYVAPELLQSATKV 831
LD + H+KI DFG+ K+ +G + T GT Y+APE+L
Sbjct: 511 LLDKDGHIKIADFGMC-------------KENMLGDAKTNTFCGTPDYIAPEILLGQK-- 555
Query: 832 IYNQKVDIYSLGIILFEM 849
YN VD +S G++L+EM
Sbjct: 556 -YNHSVDWWSFGVLLYEM 572
>CR536517-1|CAG38755.1| 556|Homo sapiens PDPK1 protein.
Length = 556
Score = 69.3 bits (162), Expect = 1e-10
Identities = 52/161 (32%), Positives = 83/161 (51%), Gaps = 20/161 (12%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
EIV L ++H +G+IHRDLKP NI L+ + H++I DFG T + ++KQ
Sbjct: 188 EIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG------TAKVLSPESKQARANS 241
Query: 809 SLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH--PPLETGMERMMVLTN 866
+GTA YV+PELL T+ + D+++LG I++++ PP G E ++
Sbjct: 242 F----VGTAQYVSPELL---TEKSACKSSDLWALGCIIYQLVAGLPPFRAGNE-YLIFQK 293
Query: 867 LRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAEL 907
+ + P KF K ++ LL +A+ R C E+
Sbjct: 294 IIKLEYDFPEKF----FPKARDLVEKLLVLDATKRLGCEEM 330
Score = 38.3 bits (85), Expect = 0.22
Identities = 29/116 (25%), Positives = 52/116 (44%), Gaps = 12/116 (10%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
+Y S+ L ++K+ F + R ++SAL LH IIHRD++ E
Sbjct: 155 LYFGLSYAKNGELLKYIRKIGSFDET-----CTRFYTAEIVSALEYLHGKGIIHRDLKPE 209
Query: 396 NVFVDDVGQVKLVGASLDTRLAEMLDNDNYCDKQTPAQDIYATGQLLLSIVCKEKS 451
N+ +++ +++ D A++L ++ KQ A T Q + + EKS
Sbjct: 210 NILLNEDMHIQIT----DFGTAKVLSPES---KQARANSFVGTAQYVSPELLTEKS 258
>BC113359-1|AAI13360.1| 706|Homo sapiens protein kinase C, theta
protein.
Length = 706
Score = 69.3 bits (162), Expect = 1e-10
Identities = 47/138 (34%), Positives = 70/138 (50%), Gaps = 17/138 (12%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
K+ L+ ME+ L I + + RA EI+ GL +H +G+++RDLK NI
Sbjct: 451 KENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNI 510
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQI-GTALYVAPELLQSATKV 831
LD + H+KI DFG+ K+ +G + T GT Y+APE+L
Sbjct: 511 LLDKDGHIKIADFGMC-------------KENMLGDAKTNTFCGTPDYIAPEILLGQK-- 555
Query: 832 IYNQKVDIYSLGIILFEM 849
YN VD +S G++L+EM
Sbjct: 556 -YNHSVDWWSFGVLLYEM 572
>BC101465-1|AAI01466.1| 706|Homo sapiens protein kinase C, theta
protein.
Length = 706
Score = 69.3 bits (162), Expect = 1e-10
Identities = 47/138 (34%), Positives = 70/138 (50%), Gaps = 17/138 (12%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
K+ L+ ME+ L I + + RA EI+ GL +H +G+++RDLK NI
Sbjct: 451 KENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNI 510
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQI-GTALYVAPELLQSATKV 831
LD + H+KI DFG+ K+ +G + T GT Y+APE+L
Sbjct: 511 LLDKDGHIKIADFGMC-------------KENMLGDAKTNTFCGTPDYIAPEILLGQK-- 555
Query: 832 IYNQKVDIYSLGIILFEM 849
YN VD +S G++L+EM
Sbjct: 556 -YNHSVDWWSFGVLLYEM 572
>BC099905-1|AAH99905.1| 360|Homo sapiens mitogen-activated protein
kinase 1 protein.
Length = 360
Score = 69.3 bits (162), Expect = 1e-10
Identities = 51/150 (34%), Positives = 80/150 (53%), Gaps = 16/150 (10%)
Query: 700 DVVDAPRPQSERLKQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQ 759
D++ AP E++K V YI + E + L +H + L+ +I+ GL ++H
Sbjct: 88 DIIRAPT--IEQMKDV-YIVQDLMETDLYKLLKTQHLSNDHI-CYFLY-QILRGLKYIHS 142
Query: 760 RGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALY 819
++HRDLKP N+ L++ ++I DFGLA A P D T G LT + T Y
Sbjct: 143 ANVLHRDLKPSNLLLNTTCDLEICDFGLARVAD---PDHDHT------GFLTEYVATRWY 193
Query: 820 VAPELLQSATKVIYNQKVDIYSLGIILFEM 849
APE++ ++ Y + +DI+S+G IL EM
Sbjct: 194 RAPEIMLNSKG--YTKSIDIWSVGCILAEM 221
Score = 35.5 bits (78), Expect = 1.5
Identities = 17/58 (29%), Positives = 33/58 (56%), Gaps = 1/58 (1%)
Query: 539 LAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENVV 596
L+++G+GA+G V + ++ AIK++ + + RE+K+L R HEN++
Sbjct: 28 LSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTL-REIKILLRSRHENII 84
>BC012103-1|AAH12103.1| 556|Homo sapiens 3-phosphoinositide
dependent protein kinase-1 protein.
Length = 556
Score = 69.3 bits (162), Expect = 1e-10
Identities = 52/161 (32%), Positives = 83/161 (51%), Gaps = 20/161 (12%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
EIV L ++H +G+IHRDLKP NI L+ + H++I DFG T + ++KQ
Sbjct: 188 EIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG------TAKVLSPESKQARANS 241
Query: 809 SLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH--PPLETGMERMMVLTN 866
+GTA YV+PELL T+ + D+++LG I++++ PP G E ++
Sbjct: 242 F----VGTAQYVSPELL---TEKSACKSSDLWALGCIIYQLVAGLPPFRAGNE-YLIFQK 293
Query: 867 LRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAEL 907
+ + P KF K ++ LL +A+ R C E+
Sbjct: 294 IIKLEYDFPEKF----FPKARDLVEKLLVLDATKRLGCEEM 330
Score = 38.3 bits (85), Expect = 0.22
Identities = 29/116 (25%), Positives = 52/116 (44%), Gaps = 12/116 (10%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
+Y S+ L ++K+ F + R ++SAL LH IIHRD++ E
Sbjct: 155 LYFGLSYAKNGELLKYIRKIGSFDET-----CTRFYTAEIVSALEYLHGKGIIHRDLKPE 209
Query: 396 NVFVDDVGQVKLVGASLDTRLAEMLDNDNYCDKQTPAQDIYATGQLLLSIVCKEKS 451
N+ +++ +++ D A++L ++ KQ A T Q + + EKS
Sbjct: 210 NILLNEDMHIQIT----DFGTAKVLSPES---KQARANSFVGTAQYVSPELLTEKS 258
>AL627308-5|CAH71336.1| 1732|Homo sapiens CDC42 binding protein
kinase alpha (DMPK-like) protein.
Length = 1732
Score = 69.3 bits (162), Expect = 1e-10
Identities = 47/145 (32%), Positives = 74/145 (51%), Gaps = 17/145 (11%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
E+V + VHQ +HRD+KP NI +D N H+++ DFG K +ED T Q +
Sbjct: 184 EMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKL-----MEDGTVQSSVA- 237
Query: 809 SLTGQIGTALYVAPELLQSAT--KVIYNQKVDIYSLGIILFEMFH--PPL--ETGMERMM 862
+GT Y++PE+LQ+ K Y + D +SLG+ ++EM + P E+ +E
Sbjct: 238 -----VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYG 292
Query: 863 VLTNLRSKDIVIPNKFDVDENVKQI 887
+ N + + DV EN K +
Sbjct: 293 KIMNHKERFQFPAQVTDVSENAKDL 317
Score = 34.3 bits (75), Expect = 3.5
Identities = 20/83 (24%), Positives = 42/83 (50%), Gaps = 4/83 (4%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
+Y+ + +G L L+ K F D ++A+ V+ A++ +H + +HRD++ +
Sbjct: 150 LYLVMDYYVGGDLLTLLSK---FEDRLPEDMARFYLAEMVI-AIDSVHQLHYVHRDIKPD 205
Query: 396 NVFVDDVGQVKLVGASLDTRLAE 418
N+ +D G ++L +L E
Sbjct: 206 NILMDMNGHIRLADFGSCLKLME 228
>AL627308-4|CAH71338.1| 1638|Homo sapiens CDC42 binding protein
kinase alpha (DMPK-like) protein.
Length = 1638
Score = 69.3 bits (162), Expect = 1e-10
Identities = 47/145 (32%), Positives = 74/145 (51%), Gaps = 17/145 (11%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
E+V + VHQ +HRD+KP NI +D N H+++ DFG K +ED T Q +
Sbjct: 184 EMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKL-----MEDGTVQSSVA- 237
Query: 809 SLTGQIGTALYVAPELLQSAT--KVIYNQKVDIYSLGIILFEMFH--PPL--ETGMERMM 862
+GT Y++PE+LQ+ K Y + D +SLG+ ++EM + P E+ +E
Sbjct: 238 -----VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYG 292
Query: 863 VLTNLRSKDIVIPNKFDVDENVKQI 887
+ N + + DV EN K +
Sbjct: 293 KIMNHKERFQFPAQVTDVSENAKDL 317
Score = 34.3 bits (75), Expect = 3.5
Identities = 20/83 (24%), Positives = 42/83 (50%), Gaps = 4/83 (4%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
+Y+ + +G L L+ K F D ++A+ V+ A++ +H + +HRD++ +
Sbjct: 150 LYLVMDYYVGGDLLTLLSK---FEDRLPEDMARFYLAEMVI-AIDSVHQLHYVHRDIKPD 205
Query: 396 NVFVDDVGQVKLVGASLDTRLAE 418
N+ +D G ++L +L E
Sbjct: 206 NILMDMNGHIRLADFGSCLKLME 228
>AL627308-3|CAH71337.1| 1719|Homo sapiens CDC42 binding protein
kinase alpha (DMPK-like) protein.
Length = 1719
Score = 69.3 bits (162), Expect = 1e-10
Identities = 47/145 (32%), Positives = 74/145 (51%), Gaps = 17/145 (11%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
E+V + VHQ +HRD+KP NI +D N H+++ DFG K +ED T Q +
Sbjct: 184 EMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKL-----MEDGTVQSSVA- 237
Query: 809 SLTGQIGTALYVAPELLQSAT--KVIYNQKVDIYSLGIILFEMFH--PPL--ETGMERMM 862
+GT Y++PE+LQ+ K Y + D +SLG+ ++EM + P E+ +E
Sbjct: 238 -----VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYG 292
Query: 863 VLTNLRSKDIVIPNKFDVDENVKQI 887
+ N + + DV EN K +
Sbjct: 293 KIMNHKERFQFPAQVTDVSENAKDL 317
Score = 34.3 bits (75), Expect = 3.5
Identities = 20/83 (24%), Positives = 42/83 (50%), Gaps = 4/83 (4%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
+Y+ + +G L L+ K F D ++A+ V+ A++ +H + +HRD++ +
Sbjct: 150 LYLVMDYYVGGDLLTLLSK---FEDRLPEDMARFYLAEMVI-AIDSVHQLHYVHRDIKPD 205
Query: 396 NVFVDDVGQVKLVGASLDTRLAE 418
N+ +D G ++L +L E
Sbjct: 206 NILMDMNGHIRLADFGSCLKLME 228
>AL451047-3|CAH71185.1| 1732|Homo sapiens CDC42 binding protein
kinase alpha (DMPK-like) protein.
Length = 1732
Score = 69.3 bits (162), Expect = 1e-10
Identities = 47/145 (32%), Positives = 74/145 (51%), Gaps = 17/145 (11%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
E+V + VHQ +HRD+KP NI +D N H+++ DFG K +ED T Q +
Sbjct: 184 EMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKL-----MEDGTVQSSVA- 237
Query: 809 SLTGQIGTALYVAPELLQSAT--KVIYNQKVDIYSLGIILFEMFH--PPL--ETGMERMM 862
+GT Y++PE+LQ+ K Y + D +SLG+ ++EM + P E+ +E
Sbjct: 238 -----VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYG 292
Query: 863 VLTNLRSKDIVIPNKFDVDENVKQI 887
+ N + + DV EN K +
Sbjct: 293 KIMNHKERFQFPAQVTDVSENAKDL 317
Score = 34.3 bits (75), Expect = 3.5
Identities = 20/83 (24%), Positives = 42/83 (50%), Gaps = 4/83 (4%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
+Y+ + +G L L+ K F D ++A+ V+ A++ +H + +HRD++ +
Sbjct: 150 LYLVMDYYVGGDLLTLLSK---FEDRLPEDMARFYLAEMVI-AIDSVHQLHYVHRDIKPD 205
Query: 396 NVFVDDVGQVKLVGASLDTRLAE 418
N+ +D G ++L +L E
Sbjct: 206 NILMDMNGHIRLADFGSCLKLME 228
>AL451047-2|CAH71184.1| 1638|Homo sapiens CDC42 binding protein
kinase alpha (DMPK-like) protein.
Length = 1638
Score = 69.3 bits (162), Expect = 1e-10
Identities = 47/145 (32%), Positives = 74/145 (51%), Gaps = 17/145 (11%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
E+V + VHQ +HRD+KP NI +D N H+++ DFG K +ED T Q +
Sbjct: 184 EMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKL-----MEDGTVQSSVA- 237
Query: 809 SLTGQIGTALYVAPELLQSAT--KVIYNQKVDIYSLGIILFEMFH--PPL--ETGMERMM 862
+GT Y++PE+LQ+ K Y + D +SLG+ ++EM + P E+ +E
Sbjct: 238 -----VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYG 292
Query: 863 VLTNLRSKDIVIPNKFDVDENVKQI 887
+ N + + DV EN K +
Sbjct: 293 KIMNHKERFQFPAQVTDVSENAKDL 317
Score = 34.3 bits (75), Expect = 3.5
Identities = 20/83 (24%), Positives = 42/83 (50%), Gaps = 4/83 (4%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
+Y+ + +G L L+ K F D ++A+ V+ A++ +H + +HRD++ +
Sbjct: 150 LYLVMDYYVGGDLLTLLSK---FEDRLPEDMARFYLAEMVI-AIDSVHQLHYVHRDIKPD 205
Query: 396 NVFVDDVGQVKLVGASLDTRLAE 418
N+ +D G ++L +L E
Sbjct: 206 NILMDMNGHIRLADFGSCLKLME 228
>AL451047-1|CAH71183.1| 1719|Homo sapiens CDC42 binding protein
kinase alpha (DMPK-like) protein.
Length = 1719
Score = 69.3 bits (162), Expect = 1e-10
Identities = 47/145 (32%), Positives = 74/145 (51%), Gaps = 17/145 (11%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
E+V + VHQ +HRD+KP NI +D N H+++ DFG K +ED T Q +
Sbjct: 184 EMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKL-----MEDGTVQSSVA- 237
Query: 809 SLTGQIGTALYVAPELLQSAT--KVIYNQKVDIYSLGIILFEMFH--PPL--ETGMERMM 862
+GT Y++PE+LQ+ K Y + D +SLG+ ++EM + P E+ +E
Sbjct: 238 -----VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYG 292
Query: 863 VLTNLRSKDIVIPNKFDVDENVKQI 887
+ N + + DV EN K +
Sbjct: 293 KIMNHKERFQFPAQVTDVSENAKDL 317
Score = 34.3 bits (75), Expect = 3.5
Identities = 20/83 (24%), Positives = 42/83 (50%), Gaps = 4/83 (4%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
+Y+ + +G L L+ K F D ++A+ V+ A++ +H + +HRD++ +
Sbjct: 150 LYLVMDYYVGGDLLTLLSK---FEDRLPEDMARFYLAEMVI-AIDSVHQLHYVHRDIKPD 205
Query: 396 NVFVDDVGQVKLVGASLDTRLAE 418
N+ +D G ++L +L E
Sbjct: 206 NILMDMNGHIRLADFGSCLKLME 228
>AL353689-9|CAI19109.1| 1732|Homo sapiens CDC42 binding protein
kinase alpha (DMPK-like) protein.
Length = 1732
Score = 69.3 bits (162), Expect = 1e-10
Identities = 47/145 (32%), Positives = 74/145 (51%), Gaps = 17/145 (11%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
E+V + VHQ +HRD+KP NI +D N H+++ DFG K +ED T Q +
Sbjct: 184 EMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKL-----MEDGTVQSSVA- 237
Query: 809 SLTGQIGTALYVAPELLQSAT--KVIYNQKVDIYSLGIILFEMFH--PPL--ETGMERMM 862
+GT Y++PE+LQ+ K Y + D +SLG+ ++EM + P E+ +E
Sbjct: 238 -----VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYG 292
Query: 863 VLTNLRSKDIVIPNKFDVDENVKQI 887
+ N + + DV EN K +
Sbjct: 293 KIMNHKERFQFPAQVTDVSENAKDL 317
Score = 34.3 bits (75), Expect = 3.5
Identities = 20/83 (24%), Positives = 42/83 (50%), Gaps = 4/83 (4%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
+Y+ + +G L L+ K F D ++A+ V+ A++ +H + +HRD++ +
Sbjct: 150 LYLVMDYYVGGDLLTLLSK---FEDRLPEDMARFYLAEMVI-AIDSVHQLHYVHRDIKPD 205
Query: 396 NVFVDDVGQVKLVGASLDTRLAE 418
N+ +D G ++L +L E
Sbjct: 206 NILMDMNGHIRLADFGSCLKLME 228
>AL353689-8|CAI19110.1| 1638|Homo sapiens CDC42 binding protein
kinase alpha (DMPK-like) protein.
Length = 1638
Score = 69.3 bits (162), Expect = 1e-10
Identities = 47/145 (32%), Positives = 74/145 (51%), Gaps = 17/145 (11%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
E+V + VHQ +HRD+KP NI +D N H+++ DFG K +ED T Q +
Sbjct: 184 EMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKL-----MEDGTVQSSVA- 237
Query: 809 SLTGQIGTALYVAPELLQSAT--KVIYNQKVDIYSLGIILFEMFH--PPL--ETGMERMM 862
+GT Y++PE+LQ+ K Y + D +SLG+ ++EM + P E+ +E
Sbjct: 238 -----VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYG 292
Query: 863 VLTNLRSKDIVIPNKFDVDENVKQI 887
+ N + + DV EN K +
Sbjct: 293 KIMNHKERFQFPAQVTDVSENAKDL 317
Score = 34.3 bits (75), Expect = 3.5
Identities = 20/83 (24%), Positives = 42/83 (50%), Gaps = 4/83 (4%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
+Y+ + +G L L+ K F D ++A+ V+ A++ +H + +HRD++ +
Sbjct: 150 LYLVMDYYVGGDLLTLLSK---FEDRLPEDMARFYLAEMVI-AIDSVHQLHYVHRDIKPD 205
Query: 396 NVFVDDVGQVKLVGASLDTRLAE 418
N+ +D G ++L +L E
Sbjct: 206 NILMDMNGHIRLADFGSCLKLME 228
>AL353689-7|CAI19108.1| 1719|Homo sapiens CDC42 binding protein
kinase alpha (DMPK-like) protein.
Length = 1719
Score = 69.3 bits (162), Expect = 1e-10
Identities = 47/145 (32%), Positives = 74/145 (51%), Gaps = 17/145 (11%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
E+V + VHQ +HRD+KP NI +D N H+++ DFG K +ED T Q +
Sbjct: 184 EMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKL-----MEDGTVQSSVA- 237
Query: 809 SLTGQIGTALYVAPELLQSAT--KVIYNQKVDIYSLGIILFEMFH--PPL--ETGMERMM 862
+GT Y++PE+LQ+ K Y + D +SLG+ ++EM + P E+ +E
Sbjct: 238 -----VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYG 292
Query: 863 VLTNLRSKDIVIPNKFDVDENVKQI 887
+ N + + DV EN K +
Sbjct: 293 KIMNHKERFQFPAQVTDVSENAKDL 317
Score = 34.3 bits (75), Expect = 3.5
Identities = 20/83 (24%), Positives = 42/83 (50%), Gaps = 4/83 (4%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
+Y+ + +G L L+ K F D ++A+ V+ A++ +H + +HRD++ +
Sbjct: 150 LYLVMDYYVGGDLLTLLSK---FEDRLPEDMARFYLAEMVI-AIDSVHQLHYVHRDIKPD 205
Query: 396 NVFVDDVGQVKLVGASLDTRLAE 418
N+ +D G ++L +L E
Sbjct: 206 NILMDMNGHIRLADFGSCLKLME 228
>AL158043-2|CAC12904.2| 706|Homo sapiens protein kinase C, theta
protein.
Length = 706
Score = 69.3 bits (162), Expect = 1e-10
Identities = 47/138 (34%), Positives = 70/138 (50%), Gaps = 17/138 (12%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
K+ L+ ME+ L I + + RA EI+ GL +H +G+++RDLK NI
Sbjct: 451 KENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNI 510
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQI-GTALYVAPELLQSATKV 831
LD + H+KI DFG+ K+ +G + T GT Y+APE+L
Sbjct: 511 LLDKDGHIKIADFGMC-------------KENMLGDAKTNTFCGTPDYIAPEILLGQK-- 555
Query: 832 IYNQKVDIYSLGIILFEM 849
YN VD +S G++L+EM
Sbjct: 556 -YNHSVDWWSFGVLLYEM 572
>AL158043-1|CAI16127.1| 478|Homo sapiens protein kinase C, theta
protein.
Length = 478
Score = 69.3 bits (162), Expect = 1e-10
Identities = 47/138 (34%), Positives = 70/138 (50%), Gaps = 17/138 (12%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
K+ L+ ME+ L I + + RA EI+ GL +H +G+++RDLK NI
Sbjct: 223 KENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNI 282
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQI-GTALYVAPELLQSATKV 831
LD + H+KI DFG+ K+ +G + T GT Y+APE+L
Sbjct: 283 LLDKDGHIKIADFGMC-------------KENMLGDAKTNTFCGTPDYIAPEILLGQK-- 327
Query: 832 IYNQKVDIYSLGIILFEM 849
YN VD +S G++L+EM
Sbjct: 328 -YNHSVDWWSFGVLLYEM 344
>AL137145-2|CAC10200.2| 706|Homo sapiens protein kinase C, theta
protein.
Length = 706
Score = 69.3 bits (162), Expect = 1e-10
Identities = 47/138 (34%), Positives = 70/138 (50%), Gaps = 17/138 (12%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
K+ L+ ME+ L I + + RA EI+ GL +H +G+++RDLK NI
Sbjct: 451 KENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNI 510
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQI-GTALYVAPELLQSATKV 831
LD + H+KI DFG+ K+ +G + T GT Y+APE+L
Sbjct: 511 LLDKDGHIKIADFGMC-------------KENMLGDAKTNTFCGTPDYIAPEILLGQK-- 555
Query: 832 IYNQKVDIYSLGIILFEM 849
YN VD +S G++L+EM
Sbjct: 556 -YNHSVDWWSFGVLLYEM 572
>AL137145-1|CAI15756.1| 478|Homo sapiens protein kinase C, theta
protein.
Length = 478
Score = 69.3 bits (162), Expect = 1e-10
Identities = 47/138 (34%), Positives = 70/138 (50%), Gaps = 17/138 (12%)
Query: 713 KQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNI 772
K+ L+ ME+ L I + + RA EI+ GL +H +G+++RDLK NI
Sbjct: 223 KENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNI 282
Query: 773 FLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQI-GTALYVAPELLQSATKV 831
LD + H+KI DFG+ K+ +G + T GT Y+APE+L
Sbjct: 283 LLDKDGHIKIADFGMC-------------KENMLGDAKTNTFCGTPDYIAPEILLGQK-- 327
Query: 832 IYNQKVDIYSLGIILFEM 849
YN VD +S G++L+EM
Sbjct: 328 -YNHSVDWWSFGVLLYEM 344
>AJ518976-1|CAD57746.1| 1638|Homo sapiens CDC42 binding protein
kinase alpha (DMPK-like) protein.
Length = 1638
Score = 69.3 bits (162), Expect = 1e-10
Identities = 47/145 (32%), Positives = 74/145 (51%), Gaps = 17/145 (11%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
E+V + VHQ +HRD+KP NI +D N H+++ DFG K +ED T Q +
Sbjct: 184 EMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKL-----MEDGTVQSSVA- 237
Query: 809 SLTGQIGTALYVAPELLQSAT--KVIYNQKVDIYSLGIILFEMFH--PPL--ETGMERMM 862
+GT Y++PE+LQ+ K Y + D +SLG+ ++EM + P E+ +E
Sbjct: 238 -----VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYG 292
Query: 863 VLTNLRSKDIVIPNKFDVDENVKQI 887
+ N + + DV EN K +
Sbjct: 293 KIMNHKERFQFPAQVTDVSENAKDL 317
Score = 34.3 bits (75), Expect = 3.5
Identities = 20/83 (24%), Positives = 42/83 (50%), Gaps = 4/83 (4%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
+Y+ + +G L L+ K F D ++A+ V+ A++ +H + +HRD++ +
Sbjct: 150 LYLVMDYYVGGDLLTLLSK---FEDRLPEDMARFYLAEMVI-AIDSVHQLHYVHRDIKPD 205
Query: 396 NVFVDDVGQVKLVGASLDTRLAE 418
N+ +D G ++L +L E
Sbjct: 206 NILMDMNGHIRLADFGSCLKLME 228
>AJ518975-1|CAD57745.1| 1719|Homo sapiens CDC42 binding protein
kinase alpha (DMPK-like) protein.
Length = 1719
Score = 69.3 bits (162), Expect = 1e-10
Identities = 47/145 (32%), Positives = 74/145 (51%), Gaps = 17/145 (11%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
E+V + VHQ +HRD+KP NI +D N H+++ DFG K +ED T Q +
Sbjct: 184 EMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKL-----MEDGTVQSSVA- 237
Query: 809 SLTGQIGTALYVAPELLQSAT--KVIYNQKVDIYSLGIILFEMFH--PPL--ETGMERMM 862
+GT Y++PE+LQ+ K Y + D +SLG+ ++EM + P E+ +E
Sbjct: 238 -----VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYG 292
Query: 863 VLTNLRSKDIVIPNKFDVDENVKQI 887
+ N + + DV EN K +
Sbjct: 293 KIMNHKERFQFPAQVTDVSENAKDL 317
Score = 34.3 bits (75), Expect = 3.5
Identities = 20/83 (24%), Positives = 42/83 (50%), Gaps = 4/83 (4%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
+Y+ + +G L L+ K F D ++A+ V+ A++ +H + +HRD++ +
Sbjct: 150 LYLVMDYYVGGDLLTLLSK---FEDRLPEDMARFYLAEMVI-AIDSVHQLHYVHRDIKPD 205
Query: 396 NVFVDDVGQVKLVGASLDTRLAE 418
N+ +D G ++L +L E
Sbjct: 206 NILMDMNGHIRLADFGSCLKLME 228
>AF017995-1|AAC51825.1| 556|Homo sapiens 3-phosphoinositide
dependent protein kinase-1 protein.
Length = 556
Score = 69.3 bits (162), Expect = 1e-10
Identities = 52/161 (32%), Positives = 83/161 (51%), Gaps = 20/161 (12%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
EIV L ++H +G+IHRDLKP NI L+ + H++I DFG T + ++KQ
Sbjct: 188 EIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG------TAKVLSPESKQARANS 241
Query: 809 SLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH--PPLETGMERMMVLTN 866
+GTA YV+PELL T+ + D+++LG I++++ PP G E ++
Sbjct: 242 F----VGTAQYVSPELL---TEKSACKSSDLWALGCIIYQLVAGLPPFRAGNE-YLIFQK 293
Query: 867 LRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAEL 907
+ + P KF K ++ LL +A+ R C E+
Sbjct: 294 IIKLEYDFPEKF----FPKARDLVEKLLVLDATKRLGCEEM 330
Score = 38.3 bits (85), Expect = 0.22
Identities = 29/116 (25%), Positives = 52/116 (44%), Gaps = 12/116 (10%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
+Y S+ L ++K+ F + R ++SAL LH IIHRD++ E
Sbjct: 155 LYFGLSYAKNGELLKYIRKIGSFDET-----CTRFYTAEIVSALEYLHGKGIIHRDLKPE 209
Query: 396 NVFVDDVGQVKLVGASLDTRLAEMLDNDNYCDKQTPAQDIYATGQLLLSIVCKEKS 451
N+ +++ +++ D A++L ++ KQ A T Q + + EKS
Sbjct: 210 NILLNEDMHIQIT----DFGTAKVLSPES---KQARANSFVGTAQYVSPELLTEKS 258
>AC005591-1|AAC33797.1| 367|Homo sapiens PkB-like protein.
Length = 367
Score = 69.3 bits (162), Expect = 1e-10
Identities = 52/161 (32%), Positives = 83/161 (51%), Gaps = 20/161 (12%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
EIV L ++H +G+IHRDLKP NI L+ + H++I DFG T + ++KQ
Sbjct: 180 EIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG------TAKVLSPESKQARANS 233
Query: 809 SLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH--PPLETGMERMMVLTN 866
+GTA YV+PELL T+ + D+++LG I++++ PP G E ++
Sbjct: 234 F----VGTAQYVSPELL---TEKSACKSSDLWALGCIIYQLVAGLPPFRAGNE-YLIFQK 285
Query: 867 LRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAEL 907
+ + P KF K ++ LL +A+ R C E+
Sbjct: 286 IIKLEYDFPEKF----FPKARDLVEKLLVLDATKRLGCEEM 322
Score = 38.3 bits (85), Expect = 0.22
Identities = 29/116 (25%), Positives = 52/116 (44%), Gaps = 12/116 (10%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
+Y S+ L ++K+ F + R ++SAL LH IIHRD++ E
Sbjct: 147 LYFGLSYAKNGELLKYIRKIGSFDET-----CTRFYTAEIVSALEYLHGKGIIHRDLKPE 201
Query: 396 NVFVDDVGQVKLVGASLDTRLAEMLDNDNYCDKQTPAQDIYATGQLLLSIVCKEKS 451
N+ +++ +++ D A++L ++ KQ A T Q + + EKS
Sbjct: 202 NILLNEDMHIQIT----DFGTAKVLSPES---KQARANSFVGTAQYVSPELLTEKS 250
>AB209835-1|BAD93072.1| 492|Homo sapiens 3-phosphoinositide
dependent protein kinase-1 variant protein.
Length = 492
Score = 69.3 bits (162), Expect = 1e-10
Identities = 52/161 (32%), Positives = 83/161 (51%), Gaps = 20/161 (12%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
EIV L ++H +G+IHRDLKP NI L+ + H++I DFG T + ++KQ
Sbjct: 226 EIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG------TAKVLSPESKQARANS 279
Query: 809 SLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFH--PPLETGMERMMVLTN 866
+GTA YV+PELL T+ + D+++LG I++++ PP G E ++
Sbjct: 280 F----VGTAQYVSPELL---TEKSACKSSDLWALGCIIYQLVAGLPPFRAGNE-YLIFQK 331
Query: 867 LRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAEL 907
+ + P KF K ++ LL +A+ R C E+
Sbjct: 332 IIKLEYDFPEKF----FPKARDLVEKLLVLDATKRLGCEEM 368
Score = 38.3 bits (85), Expect = 0.22
Identities = 29/116 (25%), Positives = 52/116 (44%), Gaps = 12/116 (10%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
+Y S+ L ++K+ F + R ++SAL LH IIHRD++ E
Sbjct: 193 LYFGLSYAKNGELLKYIRKIGSFDET-----CTRFYTAEIVSALEYLHGKGIIHRDLKPE 247
Query: 396 NVFVDDVGQVKLVGASLDTRLAEMLDNDNYCDKQTPAQDIYATGQLLLSIVCKEKS 451
N+ +++ +++ D A++L ++ KQ A T Q + + EKS
Sbjct: 248 NILLNEDMHIQIT----DFGTAKVLSPES---KQARANSFVGTAQYVSPELLTEKS 296
>AB208968-1|BAD92205.1| 1702|Homo sapiens CDC42 binding protein
kinase alpha variant protein.
Length = 1702
Score = 69.3 bits (162), Expect = 1e-10
Identities = 47/145 (32%), Positives = 74/145 (51%), Gaps = 17/145 (11%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
E+V + VHQ +HRD+KP NI +D N H+++ DFG K +ED T Q +
Sbjct: 195 EMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKL-----MEDGTVQSSVA- 248
Query: 809 SLTGQIGTALYVAPELLQSAT--KVIYNQKVDIYSLGIILFEMFH--PPL--ETGMERMM 862
+GT Y++PE+LQ+ K Y + D +SLG+ ++EM + P E+ +E
Sbjct: 249 -----VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYG 303
Query: 863 VLTNLRSKDIVIPNKFDVDENVKQI 887
+ N + + DV EN K +
Sbjct: 304 KIMNHKERFQFPAQVTDVSENAKDL 328
Score = 34.3 bits (75), Expect = 3.5
Identities = 20/83 (24%), Positives = 42/83 (50%), Gaps = 4/83 (4%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
+Y+ + +G L L+ K F D ++A+ V+ A++ +H + +HRD++ +
Sbjct: 161 LYLVMDYYVGGDLLTLLSK---FEDRLPEDMARFYLAEMVI-AIDSVHQLHYVHRDIKPD 216
Query: 396 NVFVDDVGQVKLVGASLDTRLAE 418
N+ +D G ++L +L E
Sbjct: 217 NILMDMNGHIRLADFGSCLKLME 239
>L41816-1|AAA99458.1| 370|Homo sapiens cam kinase I protein.
Length = 370
Score = 68.9 bits (161), Expect = 1e-10
Identities = 56/200 (28%), Positives = 98/200 (49%), Gaps = 26/200 (13%)
Query: 716 LYIQMEFCEKHTL-RQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIF- 773
LY+ M+ L + ++ G + E A RL ++++ + ++H G++HRDLKP N+
Sbjct: 91 LYLIMQLVSGGELFDRIVEKGFYTER-DASRLIFQVLDAVKYLHDLGIVHRDLKPENLLY 149
Query: 774 --LDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
LD + + I DFGL +K E+ G L+ GT YVAPE+L
Sbjct: 150 YSLDEDSKIMISDFGL-------------SKMEDPGSVLSTACGTPGYVAPEVLAQKP-- 194
Query: 832 IYNQKVDIYSLGIILFEMF--HPPLETGMERMMVLTNLRSK-DIVIPNKFDVDENVKQIH 888
Y++ VD +S+G+I + + +PP + + L+++ + P D+ ++ K
Sbjct: 195 -YSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDF- 252
Query: 889 VIRWLLNHEASLRPTCAELL 908
IR L+ + R TC + L
Sbjct: 253 -IRHLMEKDPEKRFTCEQAL 271
>BC106755-1|AAI06756.1| 370|Homo sapiens
calcium/calmodulin-dependent protein kinase I protein.
Length = 370
Score = 68.9 bits (161), Expect = 1e-10
Identities = 56/200 (28%), Positives = 98/200 (49%), Gaps = 26/200 (13%)
Query: 716 LYIQMEFCEKHTL-RQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIF- 773
LY+ M+ L + ++ G + E A RL ++++ + ++H G++HRDLKP N+
Sbjct: 91 LYLIMQLVSGGELFDRIVEKGFYTER-DASRLIFQVLDAVKYLHDLGIVHRDLKPENLLY 149
Query: 774 --LDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
LD + + I DFGL +K E+ G L+ GT YVAPE+L
Sbjct: 150 YSLDEDSKIMISDFGL-------------SKMEDPGSVLSTACGTPGYVAPEVLAQKP-- 194
Query: 832 IYNQKVDIYSLGIILFEMF--HPPLETGMERMMVLTNLRSK-DIVIPNKFDVDENVKQIH 888
Y++ VD +S+G+I + + +PP + + L+++ + P D+ ++ K
Sbjct: 195 -YSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDF- 252
Query: 889 VIRWLLNHEASLRPTCAELL 908
IR L+ + R TC + L
Sbjct: 253 -IRHLMEKDPEKRFTCEQAL 271
>BC106754-1|AAI06755.1| 370|Homo sapiens
calcium/calmodulin-dependent protein kinase I protein.
Length = 370
Score = 68.9 bits (161), Expect = 1e-10
Identities = 56/200 (28%), Positives = 98/200 (49%), Gaps = 26/200 (13%)
Query: 716 LYIQMEFCEKHTL-RQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIF- 773
LY+ M+ L + ++ G + E A RL ++++ + ++H G++HRDLKP N+
Sbjct: 91 LYLIMQLVSGGELFDRIVEKGFYTER-DASRLIFQVLDAVKYLHDLGIVHRDLKPENLLY 149
Query: 774 --LDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKV 831
LD + + I DFGL +K E+ G L+ GT YVAPE+L
Sbjct: 150 YSLDEDSKIMISDFGL-------------SKMEDPGSVLSTACGTPGYVAPEVLAQKP-- 194
Query: 832 IYNQKVDIYSLGIILFEMF--HPPLETGMERMMVLTNLRSK-DIVIPNKFDVDENVKQIH 888
Y++ VD +S+G+I + + +PP + + L+++ + P D+ ++ K
Sbjct: 195 -YSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDF- 252
Query: 889 VIRWLLNHEASLRPTCAELL 908
IR L+ + R TC + L
Sbjct: 253 -IRHLMEKDPEKRFTCEQAL 271
>BC036797-1|AAH36797.1| 387|Homo sapiens ADRBK2 protein protein.
Length = 387
Score = 68.9 bits (161), Expect = 1e-10
Identities = 44/117 (37%), Positives = 66/117 (56%), Gaps = 19/117 (16%)
Query: 734 NGLFQEHFRAWRLFR-EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAF 792
+G+F E + R + EI+ GL H+H R +++RDLKP NI LD + H +I D GLA
Sbjct: 286 HGVFSE--KEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLAC--- 340
Query: 793 TGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEM 849
D +K++ +GT Y+APE+LQ T Y+ D +SLG +LF++
Sbjct: 341 ------DFSKKKP-----HASVGTHGYMAPEVLQKGT--AYDSSADWFSLGCMLFKL 384
>AY166586-1|AAN86031.1| 1638|Homo sapiens CDC42-binding protein
kinase beta protein.
Length = 1638
Score = 68.5 bits (160), Expect = 2e-10
Identities = 38/105 (36%), Positives = 59/105 (56%), Gaps = 13/105 (12%)
Query: 749 EIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGG 808
E+V + VHQ +HRD+KP NI +D N H+++ DFG K +ED T Q +
Sbjct: 184 EMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKL-----MEDGTVQSSVA- 237
Query: 809 SLTGQIGTALYVAPELLQSAT--KVIYNQKVDIYSLGIILFEMFH 851
+GT Y++PE+LQ+ K Y + D +SLG+ ++EM +
Sbjct: 238 -----VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLY 277
Score = 34.3 bits (75), Expect = 3.5
Identities = 20/83 (24%), Positives = 42/83 (50%), Gaps = 4/83 (4%)
Query: 336 IYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSE 395
+Y+ + +G L L+ K F D ++A+ V+ A++ +H + +HRD++ +
Sbjct: 150 LYLVMDYYVGGDLLTLLSK---FEDRLPEDMARFYLAEMVI-AIDSVHQLHYVHRDIKPD 205
Query: 396 NVFVDDVGQVKLVGASLDTRLAE 418
N+ +D G ++L +L E
Sbjct: 206 NILMDMNGHIRLADFGSCLKLME 228
>U29727-1|AAA82933.1| 816|Homo sapiens BMK1 gamma kinase protein.
Length = 816
Score = 68.1 bits (159), Expect = 2e-10
Identities = 52/153 (33%), Positives = 80/153 (52%), Gaps = 17/153 (11%)
Query: 699 EDVVDAPRPQSERLKQVLYIQMEFCEKHTLRQAIDNG--LFQEHFRAWRLFREIVEGLAH 756
+D++ P E K V Y+ ++ E L Q I + L EH R + +++ GL +
Sbjct: 118 KDILRPTVPYGE-FKSV-YVVLDLMESD-LHQIIHSSQPLTLEHVRYF--LYQLLRGLKY 172
Query: 757 VHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGT 816
+H +IHRDLKP N+ ++ N +KIGDFG+A T P E + +T + T
Sbjct: 173 MHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTS-PAEHQY-------FMTEYVAT 224
Query: 817 ALYVAPELLQSATKVIYNQKVDIYSLGIILFEM 849
Y APEL+ S + Y Q +D++S+G I EM
Sbjct: 225 RWYRAPELMLSLHE--YTQAIDLWSVGCIFGEM 255
Score = 45.6 bits (103), Expect = 0.001
Identities = 20/62 (32%), Positives = 36/62 (58%)
Query: 535 EFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHEN 594
E+E++ +G GA+G V + +L G AIK++ + V K+ RE+K+L H+N
Sbjct: 54 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDN 113
Query: 595 VV 596
++
Sbjct: 114 II 115
Score = 33.9 bits (74), Expect = 4.7
Identities = 19/78 (24%), Positives = 38/78 (48%)
Query: 368 LRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAEMLDNDNYCD 427
+R+ +L L +H+A +IHRD++ N+ V++ ++K+ + L Y
Sbjct: 159 VRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFM 218
Query: 428 KQTPAQDIYATGQLLLSI 445
+ A Y +L+LS+
Sbjct: 219 TEYVATRWYRAPELMLSL 236
>U29726-1|AAA82932.1| 816|Homo sapiens BMK1 beta kinase protein.
Length = 816
Score = 68.1 bits (159), Expect = 2e-10
Identities = 52/153 (33%), Positives = 80/153 (52%), Gaps = 17/153 (11%)
Query: 699 EDVVDAPRPQSERLKQVLYIQMEFCEKHTLRQAIDNG--LFQEHFRAWRLFREIVEGLAH 756
+D++ P E K V Y+ ++ E L Q I + L EH R + +++ GL +
Sbjct: 118 KDILRPTVPYGE-FKSV-YVVLDLMESD-LHQIIHSSQPLTLEHVRYF--LYQLLRGLKY 172
Query: 757 VHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGT 816
+H +IHRDLKP N+ ++ N +KIGDFG+A T P E + +T + T
Sbjct: 173 MHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTS-PAEHQY-------FMTEYVAT 224
Query: 817 ALYVAPELLQSATKVIYNQKVDIYSLGIILFEM 849
Y APEL+ S + Y Q +D++S+G I EM
Sbjct: 225 RWYRAPELMLSLHE--YTQAIDLWSVGCIFGEM 255
Score = 45.6 bits (103), Expect = 0.001
Identities = 20/62 (32%), Positives = 36/62 (58%)
Query: 535 EFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHEN 594
E+E++ +G GA+G V + +L G AIK++ + V K+ RE+K+L H+N
Sbjct: 54 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDN 113
Query: 595 VV 596
++
Sbjct: 114 II 115
Score = 33.9 bits (74), Expect = 4.7
Identities = 19/78 (24%), Positives = 38/78 (48%)
Query: 368 LRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAEMLDNDNYCD 427
+R+ +L L +H+A +IHRD++ N+ V++ ++K+ + L Y
Sbjct: 159 VRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFM 218
Query: 428 KQTPAQDIYATGQLLLSI 445
+ A Y +L+LS+
Sbjct: 219 TEYVATRWYRAPELMLSL 236
>U29725-1|AAA82931.1| 816|Homo sapiens BMK1 alpha kinase protein.
Length = 816
Score = 68.1 bits (159), Expect = 2e-10
Identities = 52/153 (33%), Positives = 80/153 (52%), Gaps = 17/153 (11%)
Query: 699 EDVVDAPRPQSERLKQVLYIQMEFCEKHTLRQAIDNG--LFQEHFRAWRLFREIVEGLAH 756
+D++ P E K V Y+ ++ E L Q I + L EH R + +++ GL +
Sbjct: 118 KDILRPTVPYGE-FKSV-YVVLDLMESD-LHQIIHSSQPLTLEHVRYF--LYQLLRGLKY 172
Query: 757 VHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGT 816
+H +IHRDLKP N+ ++ N +KIGDFG+A T P E + +T + T
Sbjct: 173 MHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTS-PAEHQY-------FMTEYVAT 224
Query: 817 ALYVAPELLQSATKVIYNQKVDIYSLGIILFEM 849
Y APEL+ S + Y Q +D++S+G I EM
Sbjct: 225 RWYRAPELMLSLHE--YTQAIDLWSVGCIFGEM 255
Score = 45.6 bits (103), Expect = 0.001
Identities = 20/62 (32%), Positives = 36/62 (58%)
Query: 535 EFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHEN 594
E+E++ +G GA+G V + +L G AIK++ + V K+ RE+K+L H+N
Sbjct: 54 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDN 113
Query: 595 VV 596
++
Sbjct: 114 II 115
Score = 33.9 bits (74), Expect = 4.7
Identities = 19/78 (24%), Positives = 38/78 (48%)
Query: 368 LRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAEMLDNDNYCD 427
+R+ +L L +H+A +IHRD++ N+ V++ ++K+ + L Y
Sbjct: 159 VRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFM 218
Query: 428 KQTPAQDIYATGQLLLSI 445
+ A Y +L+LS+
Sbjct: 219 TEYVATRWYRAPELMLSL 236
>U25278-1|AAA81381.1| 815|Homo sapiens ERK5 protein.
Length = 815
Score = 68.1 bits (159), Expect = 2e-10
Identities = 52/153 (33%), Positives = 80/153 (52%), Gaps = 17/153 (11%)
Query: 699 EDVVDAPRPQSERLKQVLYIQMEFCEKHTLRQAIDNG--LFQEHFRAWRLFREIVEGLAH 756
+D++ P E K V Y+ ++ E L Q I + L EH R + +++ GL +
Sbjct: 117 KDILRPTVPYGE-FKSV-YVVLDLMESD-LHQIIHSSQPLTLEHVRYF--LYQLLRGLKY 171
Query: 757 VHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGT 816
+H +IHRDLKP N+ ++ N +KIGDFG+A T P E + +T + T
Sbjct: 172 MHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTS-PAEHQY-------FMTEYVAT 223
Query: 817 ALYVAPELLQSATKVIYNQKVDIYSLGIILFEM 849
Y APEL+ S + Y Q +D++S+G I EM
Sbjct: 224 RWYRAPELMLSLHE--YTQAIDLWSVGCIFGEM 254
Score = 45.6 bits (103), Expect = 0.001
Identities = 20/62 (32%), Positives = 36/62 (58%)
Query: 535 EFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHEN 594
E+E++ +G GA+G V + +L G AIK++ + V K+ RE+K+L H+N
Sbjct: 53 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDN 112
Query: 595 VV 596
++
Sbjct: 113 II 114
Score = 33.9 bits (74), Expect = 4.7
Identities = 19/78 (24%), Positives = 38/78 (48%)
Query: 368 LRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAEMLDNDNYCD 427
+R+ +L L +H+A +IHRD++ N+ V++ ++K+ + L Y
Sbjct: 158 VRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFM 217
Query: 428 KQTPAQDIYATGQLLLSI 445
+ A Y +L+LS+
Sbjct: 218 TEYVATRWYRAPELMLSL 235
>DQ201638-1|ABA27097.1| 527|Homo sapiens oxidative-stress
responsive 1 protein.
Length = 527
Score = 68.1 bits (159), Expect = 2e-10
Identities = 52/180 (28%), Positives = 90/180 (50%), Gaps = 20/180 (11%)
Query: 746 LFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEE 805
+ RE++EGL ++H+ G IHRD+K NI L + V+I DFG++ TG + ++
Sbjct: 126 ILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKT 185
Query: 806 IGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEM------FH--PPLETG 857
+GT ++APE+++ Y+ K DI+S GI E+ +H PP++
Sbjct: 186 F-------VGTPCWMAPEVMEQVRG--YDFKADIWSFGITAIELATGAAPYHKYPPMKVL 236
Query: 858 MERMMVLTNLRSKDIVIPNKFDVDENVKQIH-VIRWLLNHEASLRPTCAELLASEHVPRA 916
M + + + S + + +K + + K +I L + RPT AELL + +A
Sbjct: 237 M--LTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKA 294
Score = 33.1 bits (72), Expect = 8.1
Identities = 23/73 (31%), Positives = 37/73 (50%), Gaps = 7/73 (9%)
Query: 348 LKNLVKK---LSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQ 404
+K++V K SG D + +LR V +G L LH IHRDV++ N+ + + G
Sbjct: 104 IKHIVAKGEHKSGVLDESTIATILREVLEG----LEYLHKNGQIHRDVKAGNILLGEDGS 159
Query: 405 VKLVGASLDTRLA 417
V++ + LA
Sbjct: 160 VQIADFGVSAFLA 172
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.318 0.133 0.389
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 211,633,334
Number of Sequences: 224733
Number of extensions: 8389894
Number of successful extensions: 34643
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 2193
Number of HSP's successfully gapped in prelim test: 510
Number of HSP's that attempted gapping in prelim test: 24653
Number of HSP's gapped (non-prelim): 8445
length of query: 1564
length of database: 73,234,838
effective HSP length: 100
effective length of query: 1464
effective length of database: 50,761,538
effective search space: 74314891632
effective search space used: 74314891632
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 72 (33.1 bits)
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