Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA003151-TA|BGIBMGA003151-PA|IPR001631|DNA topoisomerase
I, C-terminal, IPR008336|DNA topoisomerase I, DNA binding,
eukaryotic-type, IPR013500|DNA topoisomerase I, catalytic core,
eukaryotic-type, IPR011010|DNA breaking-rejoining enzyme, catalytic
core, IPR013499|DNA topoisomerase I, C-terminal, eukaryotic-type
(686 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
U07804-1|AAB60379.1| 761|Homo sapiens DNA topoisomerase I protein. 655 0.0
M60706-1|AAA61206.1| 765|Homo sapiens topoisomerase I protein. 655 0.0
J03250-1|AAA61207.1| 765|Homo sapiens TOP1 protein. 655 0.0
AL035652-1|CAI19767.1| 765|Homo sapiens topoisomerase (DNA) I p... 655 0.0
AL022394-1|CAI42886.1| 765|Homo sapiens topoisomerase (DNA) I p... 655 0.0
U07806-1|AAB60380.1| 761|Homo sapiens DNA topoisomerase I protein. 651 0.0
AF349031-1|AAL10791.1| 601|Homo sapiens topoisomerase I protein. 611 e-174
AF349017-1|AAL05624.1| 601|Homo sapiens topoisomerase I protein. 611 e-174
BC071914-1|AAH71914.1| 601|Homo sapiens topoisomerase (DNA) I, ... 611 e-174
BC052285-1|AAH52285.1| 601|Homo sapiens topoisomerase (DNA) I, ... 611 e-174
BC044646-1|AAH44646.1| 602|Homo sapiens TOP1MT protein protein. 611 e-174
X16479-1|CAA34500.2| 225|Homo sapiens topoisomerase I protein. 285 5e-76
BC000943-1|AAH00943.1| 176|Homo sapiens Unknown (protein for IM... 204 6e-52
M27913-1|AAA61208.1| 109|Homo sapiens TOP1 protein. 114 1e-24
BC027453-1|AAH27453.1| 101|Homo sapiens TOP1MT protein protein. 103 3e-21
AY171233-1|AAO13168.1| 754|Homo sapiens protein tyrosine phosph... 36 0.36
AL360020-3|CAI14621.2| 806|Homo sapiens protein tyrosine phosph... 36 0.36
AL360020-2|CAM20720.1| 754|Homo sapiens protein tyrosine phosph... 36 0.36
BC118918-1|AAI18919.1| 1302|Homo sapiens cingulin-like 1 protein. 36 0.48
BC112049-1|AAI12050.1| 1302|Homo sapiens cingulin-like 1 protein. 36 0.48
BC093827-1|AAH93827.1| 1302|Homo sapiens cingulin-like 1 protein. 36 0.48
AY274808-1|AAP42073.1| 1302|Homo sapiens KIAA1749 protein protein. 36 0.48
AB051536-1|BAB21840.2| 1047|Homo sapiens KIAA1749 protein protein. 36 0.48
BC067120-1|AAH67120.1| 754|Homo sapiens protein tyrosine phosph... 36 0.63
AK027863-1|BAB55415.1| 612|Homo sapiens protein ( Homo sapiens ... 36 0.63
AY610514-1|AAT37906.1| 1302|Homo sapiens paracingulin protein. 34 1.5
AY528715-1|AAT44400.1| 1016|Homo sapiens antigen MU-RMS-40.16A p... 33 2.5
AJ131693-1|CAB40713.1| 3908|Homo sapiens AKAP450 protein protein. 33 2.5
AJ010770-1|CAA09361.1| 3911|Homo sapiens Hyperion protein protein. 33 2.5
AF083037-1|AAD22767.1| 3595|Homo sapiens A-kinase anchoring prot... 33 2.5
AC004013-1|AAB96867.2| 2058|Homo sapiens unknown protein. 33 2.5
Z82215-4|CAB05105.1| 1960|Homo sapiens myosin, heavy chain 9, no... 33 3.4
X90568-1|CAA62188.1|26926|Homo sapiens titin protein. 33 3.4
CR456526-1|CAG30412.1| 1960|Homo sapiens MYH9 protein. 33 3.4
AK131080-1|BAC85130.1| 563|Homo sapiens FLJ00279 protein protein. 33 3.4
AJ277892-2|CAD12456.1|30017|Homo sapiens Titin protein. 33 3.4
AJ277892-1|CAD12455.1|26926|Homo sapiens N2B-Titin Isoform protein. 33 3.4
AB191263-1|BAD52439.1| 1960|Homo sapiens non-muscle myosin heavy... 33 3.4
AB019691-1|BAA78718.1| 3899|Homo sapiens Centrosome- and Golgi-l... 33 3.4
AL832639-1|CAD89954.1| 1331|Homo sapiens hypothetical protein pr... 33 4.4
M31013-1|AAA36349.1| 1247|Homo sapiens protein ( Human nonmuscle... 32 5.9
BC060802-1|AAH60802.1| 487|Homo sapiens histamine receptor H1 p... 32 7.8
>U07804-1|AAB60379.1| 761|Homo sapiens DNA topoisomerase I protein.
Length = 761
Score = 655 bits (1619), Expect = 0.0
Identities = 304/430 (70%), Positives = 345/430 (80%), Gaps = 2/430 (0%)
Query: 259 KEYGFCTIDGHKEKIGNFRIEPPGLFRGRGEHPKMGKLKRRVMPEDVLINCSKDSKIPKP 318
KEYGFC +D HKE+I NF+IEPPGLFRGRG HPKMG LKRR+MPED++INCSKD+K+P P
Sbjct: 332 KEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSP 391
Query: 319 PSGHKWREVRHDNTVTWLASWTENVQQQAKYVMLNPSSKLKGEKDWQKYETARKLHKCID 378
P GHKW+EVRHDN VTWL SWTEN+Q KY+MLNPSS++KGEKDWQKYETAR+L KC+D
Sbjct: 392 PPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVD 451
Query: 379 KIRENYRADWKAKEMQVRQRAVALYFIDRLALRAGNEKDD-EQADTVGCCSLRVEHIQLH 437
KIR YR DWK+KEM+VRQRAVALYFID+LALRAGNEK++ E ADTVGCCSLRVEHI LH
Sbjct: 452 KIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLH 511
Query: 438 KEKDGKEYVVVFDFLGKDSIRYYNEVPVEKRVFKNLEIFIENKKDSDDLFDRLNTQTLNE 497
E DG+EYVV FDFLGKDSIRYYN+VPVEKRVFKNL++F+ENK+ DDLFDRLNT LN+
Sbjct: 512 PELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNK 571
Query: 498 HLKDLMPGLTAKVFRTYNASITLQKQLDELTDGDASVPEKILAYNRANRAVAILCNHQRA 557
HL+DLM GLTAKVFRTYNASITLQ+QL ELT D ++P KIL+YNRANRAVAILCNHQRA
Sbjct: 572 HLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRA 631
Query: 558 VPKGHSKSMEALKEKIQAKRDQIDEAEEDLQQASKAAK-RGSVXXXXXXXXXXXXXXXXX 616
PK KSM L+ KI AK++Q+ +A DL+ A AK
Sbjct: 632 PPKTFEKSMMNLQTKIDAKKEQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLE 691
Query: 617 XXXXXXXXXXTDRDENKTIALGTSKLNYLDPRISVAWCKKHGVPIEKIYNKTQRDKFRWA 676
TDR+ENK IALGTSKLNYLDPRI+VAWCKK GVPIEKIYNKTQR+KF WA
Sbjct: 692 EQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWA 751
Query: 677 IDMAGPDYVF 686
IDMA DY F
Sbjct: 752 IDMADEDYEF 761
Score = 108 bits (259), Expect = 7e-23
Identities = 43/58 (74%), Positives = 47/58 (81%)
Query: 173 PNKRKKKQDTETEQVWKWWEEEKTDDGTKWTFLEHKGPVFAPPYEPLPSNVKFYYDGK 230
P+ +KKK E EQ WKWWEEE+ +G KW FLEHKGPVFAPPYEPLP NVKFYYDGK
Sbjct: 184 PDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGK 241
>M60706-1|AAA61206.1| 765|Homo sapiens topoisomerase I protein.
Length = 765
Score = 655 bits (1619), Expect = 0.0
Identities = 304/430 (70%), Positives = 345/430 (80%), Gaps = 2/430 (0%)
Query: 259 KEYGFCTIDGHKEKIGNFRIEPPGLFRGRGEHPKMGKLKRRVMPEDVLINCSKDSKIPKP 318
KEYGFC +D HKE+I NF+IEPPGLFRGRG HPKMG LKRR+MPED++INCSKD+K+P P
Sbjct: 336 KEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSP 395
Query: 319 PSGHKWREVRHDNTVTWLASWTENVQQQAKYVMLNPSSKLKGEKDWQKYETARKLHKCID 378
P GHKW+EVRHDN VTWL SWTEN+Q KY+MLNPSS++KGEKDWQKYETAR+L KC+D
Sbjct: 396 PPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVD 455
Query: 379 KIRENYRADWKAKEMQVRQRAVALYFIDRLALRAGNEKDD-EQADTVGCCSLRVEHIQLH 437
KIR YR DWK+KEM+VRQRAVALYFID+LALRAGNEK++ E ADTVGCCSLRVEHI LH
Sbjct: 456 KIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLH 515
Query: 438 KEKDGKEYVVVFDFLGKDSIRYYNEVPVEKRVFKNLEIFIENKKDSDDLFDRLNTQTLNE 497
E DG+EYVV FDFLGKDSIRYYN+VPVEKRVFKNL++F+ENK+ DDLFDRLNT LN+
Sbjct: 516 PELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNK 575
Query: 498 HLKDLMPGLTAKVFRTYNASITLQKQLDELTDGDASVPEKILAYNRANRAVAILCNHQRA 557
HL+DLM GLTAKVFRTYNASITLQ+QL ELT D ++P KIL+YNRANRAVAILCNHQRA
Sbjct: 576 HLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRA 635
Query: 558 VPKGHSKSMEALKEKIQAKRDQIDEAEEDLQQASKAAK-RGSVXXXXXXXXXXXXXXXXX 616
PK KSM L+ KI AK++Q+ +A DL+ A AK
Sbjct: 636 PPKTFEKSMMNLQTKIDAKKEQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLE 695
Query: 617 XXXXXXXXXXTDRDENKTIALGTSKLNYLDPRISVAWCKKHGVPIEKIYNKTQRDKFRWA 676
TDR+ENK IALGTSKLNYLDPRI+VAWCKK GVPIEKIYNKTQR+KF WA
Sbjct: 696 EQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWA 755
Query: 677 IDMAGPDYVF 686
IDMA DY F
Sbjct: 756 IDMADEDYEF 765
Score = 108 bits (259), Expect = 7e-23
Identities = 43/58 (74%), Positives = 47/58 (81%)
Query: 173 PNKRKKKQDTETEQVWKWWEEEKTDDGTKWTFLEHKGPVFAPPYEPLPSNVKFYYDGK 230
P+ +KKK E EQ WKWWEEE+ +G KW FLEHKGPVFAPPYEPLP NVKFYYDGK
Sbjct: 188 PDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGK 245
>J03250-1|AAA61207.1| 765|Homo sapiens TOP1 protein.
Length = 765
Score = 655 bits (1619), Expect = 0.0
Identities = 304/430 (70%), Positives = 345/430 (80%), Gaps = 2/430 (0%)
Query: 259 KEYGFCTIDGHKEKIGNFRIEPPGLFRGRGEHPKMGKLKRRVMPEDVLINCSKDSKIPKP 318
KEYGFC +D HKE+I NF+IEPPGLFRGRG HPKMG LKRR+MPED++INCSKD+K+P P
Sbjct: 336 KEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSP 395
Query: 319 PSGHKWREVRHDNTVTWLASWTENVQQQAKYVMLNPSSKLKGEKDWQKYETARKLHKCID 378
P GHKW+EVRHDN VTWL SWTEN+Q KY+MLNPSS++KGEKDWQKYETAR+L KC+D
Sbjct: 396 PPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVD 455
Query: 379 KIRENYRADWKAKEMQVRQRAVALYFIDRLALRAGNEKDD-EQADTVGCCSLRVEHIQLH 437
KIR YR DWK+KEM+VRQRAVALYFID+LALRAGNEK++ E ADTVGCCSLRVEHI LH
Sbjct: 456 KIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLH 515
Query: 438 KEKDGKEYVVVFDFLGKDSIRYYNEVPVEKRVFKNLEIFIENKKDSDDLFDRLNTQTLNE 497
E DG+EYVV FDFLGKDSIRYYN+VPVEKRVFKNL++F+ENK+ DDLFDRLNT LN+
Sbjct: 516 PELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNK 575
Query: 498 HLKDLMPGLTAKVFRTYNASITLQKQLDELTDGDASVPEKILAYNRANRAVAILCNHQRA 557
HL+DLM GLTAKVFRTYNASITLQ+QL ELT D ++P KIL+YNRANRAVAILCNHQRA
Sbjct: 576 HLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRA 635
Query: 558 VPKGHSKSMEALKEKIQAKRDQIDEAEEDLQQASKAAK-RGSVXXXXXXXXXXXXXXXXX 616
PK KSM L+ KI AK++Q+ +A DL+ A AK
Sbjct: 636 PPKTFEKSMMNLQTKIDAKKEQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLE 695
Query: 617 XXXXXXXXXXTDRDENKTIALGTSKLNYLDPRISVAWCKKHGVPIEKIYNKTQRDKFRWA 676
TDR+ENK IALGTSKLNYLDPRI+VAWCKK GVPIEKIYNKTQR+KF WA
Sbjct: 696 EQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWA 755
Query: 677 IDMAGPDYVF 686
IDMA DY F
Sbjct: 756 IDMADEDYEF 765
Score = 108 bits (259), Expect = 7e-23
Identities = 43/58 (74%), Positives = 47/58 (81%)
Query: 173 PNKRKKKQDTETEQVWKWWEEEKTDDGTKWTFLEHKGPVFAPPYEPLPSNVKFYYDGK 230
P+ +KKK E EQ WKWWEEE+ +G KW FLEHKGPVFAPPYEPLP NVKFYYDGK
Sbjct: 188 PDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGK 245
>AL035652-1|CAI19767.1| 765|Homo sapiens topoisomerase (DNA) I
protein.
Length = 765
Score = 655 bits (1619), Expect = 0.0
Identities = 304/430 (70%), Positives = 345/430 (80%), Gaps = 2/430 (0%)
Query: 259 KEYGFCTIDGHKEKIGNFRIEPPGLFRGRGEHPKMGKLKRRVMPEDVLINCSKDSKIPKP 318
KEYGFC +D HKE+I NF+IEPPGLFRGRG HPKMG LKRR+MPED++INCSKD+K+P P
Sbjct: 336 KEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSP 395
Query: 319 PSGHKWREVRHDNTVTWLASWTENVQQQAKYVMLNPSSKLKGEKDWQKYETARKLHKCID 378
P GHKW+EVRHDN VTWL SWTEN+Q KY+MLNPSS++KGEKDWQKYETAR+L KC+D
Sbjct: 396 PPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVD 455
Query: 379 KIRENYRADWKAKEMQVRQRAVALYFIDRLALRAGNEKDD-EQADTVGCCSLRVEHIQLH 437
KIR YR DWK+KEM+VRQRAVALYFID+LALRAGNEK++ E ADTVGCCSLRVEHI LH
Sbjct: 456 KIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLH 515
Query: 438 KEKDGKEYVVVFDFLGKDSIRYYNEVPVEKRVFKNLEIFIENKKDSDDLFDRLNTQTLNE 497
E DG+EYVV FDFLGKDSIRYYN+VPVEKRVFKNL++F+ENK+ DDLFDRLNT LN+
Sbjct: 516 PELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNK 575
Query: 498 HLKDLMPGLTAKVFRTYNASITLQKQLDELTDGDASVPEKILAYNRANRAVAILCNHQRA 557
HL+DLM GLTAKVFRTYNASITLQ+QL ELT D ++P KIL+YNRANRAVAILCNHQRA
Sbjct: 576 HLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRA 635
Query: 558 VPKGHSKSMEALKEKIQAKRDQIDEAEEDLQQASKAAK-RGSVXXXXXXXXXXXXXXXXX 616
PK KSM L+ KI AK++Q+ +A DL+ A AK
Sbjct: 636 PPKTFEKSMMNLQTKIDAKKEQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLE 695
Query: 617 XXXXXXXXXXTDRDENKTIALGTSKLNYLDPRISVAWCKKHGVPIEKIYNKTQRDKFRWA 676
TDR+ENK IALGTSKLNYLDPRI+VAWCKK GVPIEKIYNKTQR+KF WA
Sbjct: 696 EQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWA 755
Query: 677 IDMAGPDYVF 686
IDMA DY F
Sbjct: 756 IDMADEDYEF 765
Score = 108 bits (259), Expect = 7e-23
Identities = 43/58 (74%), Positives = 47/58 (81%)
Query: 173 PNKRKKKQDTETEQVWKWWEEEKTDDGTKWTFLEHKGPVFAPPYEPLPSNVKFYYDGK 230
P+ +KKK E EQ WKWWEEE+ +G KW FLEHKGPVFAPPYEPLP NVKFYYDGK
Sbjct: 188 PDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGK 245
>AL022394-1|CAI42886.1| 765|Homo sapiens topoisomerase (DNA) I
protein.
Length = 765
Score = 655 bits (1619), Expect = 0.0
Identities = 304/430 (70%), Positives = 345/430 (80%), Gaps = 2/430 (0%)
Query: 259 KEYGFCTIDGHKEKIGNFRIEPPGLFRGRGEHPKMGKLKRRVMPEDVLINCSKDSKIPKP 318
KEYGFC +D HKE+I NF+IEPPGLFRGRG HPKMG LKRR+MPED++INCSKD+K+P P
Sbjct: 336 KEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSP 395
Query: 319 PSGHKWREVRHDNTVTWLASWTENVQQQAKYVMLNPSSKLKGEKDWQKYETARKLHKCID 378
P GHKW+EVRHDN VTWL SWTEN+Q KY+MLNPSS++KGEKDWQKYETAR+L KC+D
Sbjct: 396 PPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVD 455
Query: 379 KIRENYRADWKAKEMQVRQRAVALYFIDRLALRAGNEKDD-EQADTVGCCSLRVEHIQLH 437
KIR YR DWK+KEM+VRQRAVALYFID+LALRAGNEK++ E ADTVGCCSLRVEHI LH
Sbjct: 456 KIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLH 515
Query: 438 KEKDGKEYVVVFDFLGKDSIRYYNEVPVEKRVFKNLEIFIENKKDSDDLFDRLNTQTLNE 497
E DG+EYVV FDFLGKDSIRYYN+VPVEKRVFKNL++F+ENK+ DDLFDRLNT LN+
Sbjct: 516 PELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNK 575
Query: 498 HLKDLMPGLTAKVFRTYNASITLQKQLDELTDGDASVPEKILAYNRANRAVAILCNHQRA 557
HL+DLM GLTAKVFRTYNASITLQ+QL ELT D ++P KIL+YNRANRAVAILCNHQRA
Sbjct: 576 HLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRA 635
Query: 558 VPKGHSKSMEALKEKIQAKRDQIDEAEEDLQQASKAAK-RGSVXXXXXXXXXXXXXXXXX 616
PK KSM L+ KI AK++Q+ +A DL+ A AK
Sbjct: 636 PPKTFEKSMMNLQTKIDAKKEQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLE 695
Query: 617 XXXXXXXXXXTDRDENKTIALGTSKLNYLDPRISVAWCKKHGVPIEKIYNKTQRDKFRWA 676
TDR+ENK IALGTSKLNYLDPRI+VAWCKK GVPIEKIYNKTQR+KF WA
Sbjct: 696 EQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWA 755
Query: 677 IDMAGPDYVF 686
IDMA DY F
Sbjct: 756 IDMADEDYEF 765
Score = 108 bits (259), Expect = 7e-23
Identities = 43/58 (74%), Positives = 47/58 (81%)
Query: 173 PNKRKKKQDTETEQVWKWWEEEKTDDGTKWTFLEHKGPVFAPPYEPLPSNVKFYYDGK 230
P+ +KKK E EQ WKWWEEE+ +G KW FLEHKGPVFAPPYEPLP NVKFYYDGK
Sbjct: 188 PDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGK 245
>U07806-1|AAB60380.1| 761|Homo sapiens DNA topoisomerase I protein.
Length = 761
Score = 651 bits (1608), Expect = 0.0
Identities = 302/430 (70%), Positives = 344/430 (80%), Gaps = 2/430 (0%)
Query: 259 KEYGFCTIDGHKEKIGNFRIEPPGLFRGRGEHPKMGKLKRRVMPEDVLINCSKDSKIPKP 318
KEYGFC +D HKE+I NF+IEPPGLFRGRG HPK G LKRR+MPED++INCSKD+K+P P
Sbjct: 332 KEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKTGMLKRRIMPEDIIINCSKDAKVPSP 391
Query: 319 PSGHKWREVRHDNTVTWLASWTENVQQQAKYVMLNPSSKLKGEKDWQKYETARKLHKCID 378
P GHKW+EVRHDN VTWL SWTEN+Q KY+MLNPSS++KGEKDWQKYETAR+L KC+D
Sbjct: 392 PPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVD 451
Query: 379 KIRENYRADWKAKEMQVRQRAVALYFIDRLALRAGNEKDD-EQADTVGCCSLRVEHIQLH 437
KIR YR DWK+KEM+VRQRAVALYFID+LALRAGNEK++ E ADTVGCCSLRVEHI LH
Sbjct: 452 KIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLH 511
Query: 438 KEKDGKEYVVVFDFLGKDSIRYYNEVPVEKRVFKNLEIFIENKKDSDDLFDRLNTQTLNE 497
E DG+EYVV FDFLGKDSIRYYN+VPVEKRVFKNL++F+ENK+ DDLFDRLNT LN+
Sbjct: 512 PELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNK 571
Query: 498 HLKDLMPGLTAKVFRTYNASITLQKQLDELTDGDASVPEKILAYNRANRAVAILCNHQRA 557
HL+DLM GLTAKVFRTYNASITLQ+QL ELT D ++P KIL+YNRANRAVAILCNHQRA
Sbjct: 572 HLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRA 631
Query: 558 VPKGHSKSMEALKEKIQAKRDQIDEAEEDLQQASKAAK-RGSVXXXXXXXXXXXXXXXXX 616
PK KSM L+ KI AK++Q+ +A DL+ A AK
Sbjct: 632 PPKTFEKSMMNLQTKIDAKKEQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLE 691
Query: 617 XXXXXXXXXXTDRDENKTIALGTSKLNYLDPRISVAWCKKHGVPIEKIYNKTQRDKFRWA 676
TDR+ENK IALGTSKL+YLDPRI+VAWCKK GVPIEKIYNKTQR+KF WA
Sbjct: 692 EQLMKLEVQATDREENKQIALGTSKLSYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWA 751
Query: 677 IDMAGPDYVF 686
IDMA DY F
Sbjct: 752 IDMADEDYEF 761
Score = 108 bits (259), Expect = 7e-23
Identities = 43/58 (74%), Positives = 47/58 (81%)
Query: 173 PNKRKKKQDTETEQVWKWWEEEKTDDGTKWTFLEHKGPVFAPPYEPLPSNVKFYYDGK 230
P+ +KKK E EQ WKWWEEE+ +G KW FLEHKGPVFAPPYEPLP NVKFYYDGK
Sbjct: 184 PDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGK 241
>AF349031-1|AAL10791.1| 601|Homo sapiens topoisomerase I protein.
Length = 601
Score = 611 bits (1510), Expect = e-174
Identities = 280/432 (64%), Positives = 342/432 (79%), Gaps = 2/432 (0%)
Query: 257 IQKEYGFCTIDGHKEKIGNFRIEPPGLFRGRGEHPKMGKLKRRVMPEDVLINCSKDSKIP 316
+Q+E+G+C +DGH+EKIGNF+IEPPGLFRGRG+HPKMG LKRR+ PEDV+INCS+DSKIP
Sbjct: 170 LQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSKIP 229
Query: 317 KPPSGHKWREVRHDNTVTWLASWTENVQQQAKYVMLNPSSKLKGEKDWQKYETARKLHKC 376
+PP+GH+W+EVR DNTVTWLA+WTE+VQ KY+MLNP SKLKGE WQK+ETAR+L
Sbjct: 230 EPPAGHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFETARRLRGF 289
Query: 377 IDKIRENYRADWKAKEMQVRQRAVALYFIDRLALRAGNEKDD-EQADTVGCCSLRVEHIQ 435
+D+IR YRADWK++EM+ RQRAVALYFID+LALRAGNEK+D E ADTVGCCSLRVEH+Q
Sbjct: 290 VDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQ 349
Query: 436 LHKEKDGKEYVVVFDFLGKDSIRYYNEVPVEKRVFKNLEIFIENKKDSDDLFDRLNTQTL 495
LH E DG ++VV FDFLGKD IRYYN VPVEK V+KNL++F+ENK DDLFDRL T +L
Sbjct: 350 LHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDLFDRLTTTSL 409
Query: 496 NEHLKDLMPGLTAKVFRTYNASITLQKQLDELTDGDASVPEKILAYNRANRAVAILCNHQ 555
N+HL++LM GLTAKVFRTYNASITLQ+QL LT + S+ KIL+YNRANR VAILCNHQ
Sbjct: 410 NKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQ 469
Query: 556 RAVPKGHSKSMEALKEKIQAKRDQIDEAEEDLQQASKAAK-RGSVXXXXXXXXXXXXXXX 614
RA P KSM+ L+ KIQAK++Q+ EA +L++A K +G
Sbjct: 470 RATPSTFEKSMQNLQTKIQAKKEQVAEARAELRRARAEHKAQGDGKSRSVLEKKRRLLEK 529
Query: 615 XXXXXXXXXXXXTDRDENKTIALGTSKLNYLDPRISVAWCKKHGVPIEKIYNKTQRDKFR 674
TD++ENK +ALGTSKLNYLDPRIS+AWCK+ VP+EKIY+KTQR++F
Sbjct: 530 LQEQLAQLSVQATDKEENKQVALGTSKLNYLDPRISIAWCKRFRVPVEKIYSKTQRERFA 589
Query: 675 WAIDMAGPDYVF 686
WA+ MAG D+ F
Sbjct: 590 WALAMAGEDFEF 601
Score = 72.9 bits (171), Expect = 3e-12
Identities = 27/40 (67%), Positives = 33/40 (82%)
Query: 191 WEEEKTDDGTKWTFLEHKGPVFAPPYEPLPSNVKFYYDGK 230
WE+EK +DG KW LEHKGP FAPPYEPLP V+F+Y+G+
Sbjct: 42 WEKEKHEDGVKWRQLEHKGPYFAPPYEPLPDGVRFFYEGR 81
>AF349017-1|AAL05624.1| 601|Homo sapiens topoisomerase I protein.
Length = 601
Score = 611 bits (1510), Expect = e-174
Identities = 280/432 (64%), Positives = 342/432 (79%), Gaps = 2/432 (0%)
Query: 257 IQKEYGFCTIDGHKEKIGNFRIEPPGLFRGRGEHPKMGKLKRRVMPEDVLINCSKDSKIP 316
+Q+E+G+C +DGH+EKIGNF+IEPPGLFRGRG+HPKMG LKRR+ PEDV+INCS+DSKIP
Sbjct: 170 LQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSKIP 229
Query: 317 KPPSGHKWREVRHDNTVTWLASWTENVQQQAKYVMLNPSSKLKGEKDWQKYETARKLHKC 376
+PP+GH+W+EVR DNTVTWLA+WTE+VQ KY+MLNP SKLKGE WQK+ETAR+L
Sbjct: 230 EPPAGHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFETARRLRGF 289
Query: 377 IDKIRENYRADWKAKEMQVRQRAVALYFIDRLALRAGNEKDD-EQADTVGCCSLRVEHIQ 435
+D+IR YRADWK++EM+ RQRAVALYFID+LALRAGNEK+D E ADTVGCCSLRVEH+Q
Sbjct: 290 VDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQ 349
Query: 436 LHKEKDGKEYVVVFDFLGKDSIRYYNEVPVEKRVFKNLEIFIENKKDSDDLFDRLNTQTL 495
LH E DG ++VV FDFLGKD IRYYN VPVEK V+KNL++F+ENK DDLFDRL T +L
Sbjct: 350 LHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDLFDRLTTTSL 409
Query: 496 NEHLKDLMPGLTAKVFRTYNASITLQKQLDELTDGDASVPEKILAYNRANRAVAILCNHQ 555
N+HL++LM GLTAKVFRTYNASITLQ+QL LT + S+ KIL+YNRANR VAILCNHQ
Sbjct: 410 NKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQ 469
Query: 556 RAVPKGHSKSMEALKEKIQAKRDQIDEAEEDLQQASKAAK-RGSVXXXXXXXXXXXXXXX 614
RA P KSM+ L+ KIQAK++Q+ EA +L++A K +G
Sbjct: 470 RATPSTFEKSMQNLQTKIQAKKEQVAEARAELRRARAEHKAQGDGKSRSVLEKKRRLLEK 529
Query: 615 XXXXXXXXXXXXTDRDENKTIALGTSKLNYLDPRISVAWCKKHGVPIEKIYNKTQRDKFR 674
TD++ENK +ALGTSKLNYLDPRIS+AWCK+ VP+EKIY+KTQR++F
Sbjct: 530 LQEQLAQLSVQATDKEENKQVALGTSKLNYLDPRISIAWCKRFRVPVEKIYSKTQRERFA 589
Query: 675 WAIDMAGPDYVF 686
WA+ MAG D+ F
Sbjct: 590 WALAMAGEDFEF 601
Score = 72.9 bits (171), Expect = 3e-12
Identities = 27/40 (67%), Positives = 33/40 (82%)
Query: 191 WEEEKTDDGTKWTFLEHKGPVFAPPYEPLPSNVKFYYDGK 230
WE+EK +DG KW LEHKGP FAPPYEPLP V+F+Y+G+
Sbjct: 42 WEKEKHEDGVKWRQLEHKGPYFAPPYEPLPDGVRFFYEGR 81
>BC071914-1|AAH71914.1| 601|Homo sapiens topoisomerase (DNA) I,
mitochondrial protein.
Length = 601
Score = 611 bits (1509), Expect = e-174
Identities = 279/432 (64%), Positives = 342/432 (79%), Gaps = 2/432 (0%)
Query: 257 IQKEYGFCTIDGHKEKIGNFRIEPPGLFRGRGEHPKMGKLKRRVMPEDVLINCSKDSKIP 316
+Q+E+G+C +DGH+EKIGNF+IEPPGLFRGRG+HPKMG LKRR+ PEDV+INCS+DSKIP
Sbjct: 170 LQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSKIP 229
Query: 317 KPPSGHKWREVRHDNTVTWLASWTENVQQQAKYVMLNPSSKLKGEKDWQKYETARKLHKC 376
+PP+GH+W+EVR DNTVTWLA+WTE++Q KY+MLNP SKLKGE WQK+ETAR+L
Sbjct: 230 EPPAGHQWKEVRSDNTVTWLAAWTESIQNSIKYIMLNPCSKLKGETAWQKFETARRLRGF 289
Query: 377 IDKIRENYRADWKAKEMQVRQRAVALYFIDRLALRAGNEKDD-EQADTVGCCSLRVEHIQ 435
+D+IR YRADWK++EM+ RQRAVALYFID+LALRAGNEK+D E ADTVGCCSLRVEH+Q
Sbjct: 290 VDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQ 349
Query: 436 LHKEKDGKEYVVVFDFLGKDSIRYYNEVPVEKRVFKNLEIFIENKKDSDDLFDRLNTQTL 495
LH E DG ++VV FDFLGKD IRYYN VPVEK V+KNL++F+ENK DDLFDRL T +L
Sbjct: 350 LHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDLFDRLTTTSL 409
Query: 496 NEHLKDLMPGLTAKVFRTYNASITLQKQLDELTDGDASVPEKILAYNRANRAVAILCNHQ 555
N+HL++LM GLTAKVFRTYNASITLQ+QL LT + S+ KIL+YNRANR VAILCNHQ
Sbjct: 410 NKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQ 469
Query: 556 RAVPKGHSKSMEALKEKIQAKRDQIDEAEEDLQQASKAAK-RGSVXXXXXXXXXXXXXXX 614
RA P KSM+ L+ KIQAK++Q+ EA +L++A K +G
Sbjct: 470 RATPSTFEKSMQNLQTKIQAKKEQVAEARAELRRARAEHKAQGDGKSRSVLEKKRRLLEK 529
Query: 615 XXXXXXXXXXXXTDRDENKTIALGTSKLNYLDPRISVAWCKKHGVPIEKIYNKTQRDKFR 674
TD++ENK +ALGTSKLNYLDPRIS+AWCK+ VP+EKIY+KTQR++F
Sbjct: 530 LQEQLAQLSVQATDKEENKQVALGTSKLNYLDPRISIAWCKRFRVPVEKIYSKTQRERFA 589
Query: 675 WAIDMAGPDYVF 686
WA+ MAG D+ F
Sbjct: 590 WALAMAGEDFEF 601
Score = 72.9 bits (171), Expect = 3e-12
Identities = 27/40 (67%), Positives = 33/40 (82%)
Query: 191 WEEEKTDDGTKWTFLEHKGPVFAPPYEPLPSNVKFYYDGK 230
WE+EK +DG KW LEHKGP FAPPYEPLP V+F+Y+G+
Sbjct: 42 WEKEKHEDGVKWRQLEHKGPYFAPPYEPLPDGVRFFYEGR 81
>BC052285-1|AAH52285.1| 601|Homo sapiens topoisomerase (DNA) I,
mitochondrial protein.
Length = 601
Score = 611 bits (1509), Expect = e-174
Identities = 279/432 (64%), Positives = 342/432 (79%), Gaps = 2/432 (0%)
Query: 257 IQKEYGFCTIDGHKEKIGNFRIEPPGLFRGRGEHPKMGKLKRRVMPEDVLINCSKDSKIP 316
+Q+E+G+C +DGH+EKIGNF+IEPPGLFRGRG+HPKMG LKRR+ PEDV+INCS+DSKIP
Sbjct: 170 LQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSKIP 229
Query: 317 KPPSGHKWREVRHDNTVTWLASWTENVQQQAKYVMLNPSSKLKGEKDWQKYETARKLHKC 376
+PP+GH+W+EVR DNTVTWLA+WTE++Q KY+MLNP SKLKGE WQK+ETAR+L
Sbjct: 230 EPPAGHQWKEVRSDNTVTWLAAWTESIQNSIKYIMLNPCSKLKGETAWQKFETARRLRGF 289
Query: 377 IDKIRENYRADWKAKEMQVRQRAVALYFIDRLALRAGNEKDD-EQADTVGCCSLRVEHIQ 435
+D+IR YRADWK++EM+ RQRAVALYFID+LALRAGNEK+D E ADTVGCCSLRVEH+Q
Sbjct: 290 VDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQ 349
Query: 436 LHKEKDGKEYVVVFDFLGKDSIRYYNEVPVEKRVFKNLEIFIENKKDSDDLFDRLNTQTL 495
LH E DG ++VV FDFLGKD IRYYN VPVEK V+KNL++F+ENK DDLFDRL T +L
Sbjct: 350 LHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDLFDRLTTTSL 409
Query: 496 NEHLKDLMPGLTAKVFRTYNASITLQKQLDELTDGDASVPEKILAYNRANRAVAILCNHQ 555
N+HL++LM GLTAKVFRTYNASITLQ+QL LT + S+ KIL+YNRANR VAILCNHQ
Sbjct: 410 NKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQ 469
Query: 556 RAVPKGHSKSMEALKEKIQAKRDQIDEAEEDLQQASKAAK-RGSVXXXXXXXXXXXXXXX 614
RA P KSM+ L+ KIQAK++Q+ EA +L++A K +G
Sbjct: 470 RATPSTFEKSMQNLQTKIQAKKEQVAEARAELRRARAEHKAQGDGKSRSVLEKKRRLLEK 529
Query: 615 XXXXXXXXXXXXTDRDENKTIALGTSKLNYLDPRISVAWCKKHGVPIEKIYNKTQRDKFR 674
TD++ENK +ALGTSKLNYLDPRIS+AWCK+ VP+EKIY+KTQR++F
Sbjct: 530 LQEQLAQLSVQATDKEENKQVALGTSKLNYLDPRISIAWCKRFRVPVEKIYSKTQRERFA 589
Query: 675 WAIDMAGPDYVF 686
WA+ MAG D+ F
Sbjct: 590 WALAMAGEDFEF 601
Score = 72.9 bits (171), Expect = 3e-12
Identities = 27/40 (67%), Positives = 33/40 (82%)
Query: 191 WEEEKTDDGTKWTFLEHKGPVFAPPYEPLPSNVKFYYDGK 230
WE+EK +DG KW LEHKGP FAPPYEPLP V+F+Y+G+
Sbjct: 42 WEKEKHEDGVKWRQLEHKGPYFAPPYEPLPDGVRFFYEGR 81
>BC044646-1|AAH44646.1| 602|Homo sapiens TOP1MT protein protein.
Length = 602
Score = 611 bits (1509), Expect = e-174
Identities = 279/432 (64%), Positives = 342/432 (79%), Gaps = 2/432 (0%)
Query: 257 IQKEYGFCTIDGHKEKIGNFRIEPPGLFRGRGEHPKMGKLKRRVMPEDVLINCSKDSKIP 316
+Q+E+G+C +DGH+EKIGNF+IEPPGLFRGRG+HPKMG LKRR+ PEDV+INCS+DSKIP
Sbjct: 171 LQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSKIP 230
Query: 317 KPPSGHKWREVRHDNTVTWLASWTENVQQQAKYVMLNPSSKLKGEKDWQKYETARKLHKC 376
+PP+GH+W+EVR DNTVTWLA+WTE++Q KY+MLNP SKLKGE WQK+ETAR+L
Sbjct: 231 EPPAGHQWKEVRSDNTVTWLAAWTESIQNSIKYIMLNPCSKLKGETAWQKFETARRLRGF 290
Query: 377 IDKIRENYRADWKAKEMQVRQRAVALYFIDRLALRAGNEKDD-EQADTVGCCSLRVEHIQ 435
+D+IR YRADWK++EM+ RQRAVALYFID+LALRAGNEK+D E ADTVGCCSLRVEH+Q
Sbjct: 291 VDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQ 350
Query: 436 LHKEKDGKEYVVVFDFLGKDSIRYYNEVPVEKRVFKNLEIFIENKKDSDDLFDRLNTQTL 495
LH E DG ++VV FDFLGKD IRYYN VPVEK V+KNL++F+ENK DDLFDRL T +L
Sbjct: 351 LHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDLFDRLTTTSL 410
Query: 496 NEHLKDLMPGLTAKVFRTYNASITLQKQLDELTDGDASVPEKILAYNRANRAVAILCNHQ 555
N+HL++LM GLTAKVFRTYNASITLQ+QL LT + S+ KIL+YNRANR VAILCNHQ
Sbjct: 411 NKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQ 470
Query: 556 RAVPKGHSKSMEALKEKIQAKRDQIDEAEEDLQQASKAAK-RGSVXXXXXXXXXXXXXXX 614
RA P KSM+ L+ KIQAK++Q+ EA +L++A K +G
Sbjct: 471 RATPSTFEKSMQNLQTKIQAKKEQVAEARAELRRARAEHKAQGDGKSRSVLEKKRRLLEK 530
Query: 615 XXXXXXXXXXXXTDRDENKTIALGTSKLNYLDPRISVAWCKKHGVPIEKIYNKTQRDKFR 674
TD++ENK +ALGTSKLNYLDPRIS+AWCK+ VP+EKIY+KTQR++F
Sbjct: 531 LQEQLAQLSVQATDKEENKQVALGTSKLNYLDPRISIAWCKRFRVPVEKIYSKTQRERFA 590
Query: 675 WAIDMAGPDYVF 686
WA+ MAG D+ F
Sbjct: 591 WALAMAGEDFEF 602
Score = 72.9 bits (171), Expect = 3e-12
Identities = 27/40 (67%), Positives = 33/40 (82%)
Query: 191 WEEEKTDDGTKWTFLEHKGPVFAPPYEPLPSNVKFYYDGK 230
WE+EK +DG KW LEHKGP FAPPYEPLP V+F+Y+G+
Sbjct: 43 WEKEKHEDGVKWRQLEHKGPYFAPPYEPLPDGVRFFYEGR 82
>X16479-1|CAA34500.2| 225|Homo sapiens topoisomerase I protein.
Length = 225
Score = 285 bits (698), Expect = 5e-76
Identities = 143/225 (63%), Positives = 162/225 (72%), Gaps = 1/225 (0%)
Query: 463 VPVEKRVFKNLEIFIENKKDSDDLFDRLNTQTLNEHLKDLMPGLTAKVFRTYNASITLQK 522
VPVEKRVFKNL++F+ENK+ DDLFDRLNT LN+HL+DLM GLTAKVFRTYNASITLQ+
Sbjct: 1 VPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQ 60
Query: 523 QLDELTDGDASVPEKILAYNRANRAVAILCNHQRAVPKGHSKSMEALKEKIQAKRDQIDE 582
QL ELT D ++P KIL+YNRANRAVAILCNHQRA PK KSM L+ KI AK++Q+ +
Sbjct: 61 QLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLAD 120
Query: 583 AEEDLQQASKAAK-RGSVXXXXXXXXXXXXXXXXXXXXXXXXXXXTDRDENKTIALGTSK 641
A DL+ A AK TDR+ENK IALGTSK
Sbjct: 121 ARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSK 180
Query: 642 LNYLDPRISVAWCKKHGVPIEKIYNKTQRDKFRWAIDMAGPDYVF 686
LNYLDPRI+VAWCKK GVPIEKIYNKTQR+KF WAIDMA DY F
Sbjct: 181 LNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF 225
>BC000943-1|AAH00943.1| 176|Homo sapiens Unknown (protein for
IMAGE:3448011) protein.
Length = 176
Score = 204 bits (499), Expect = 6e-52
Identities = 105/176 (59%), Positives = 118/176 (67%), Gaps = 1/176 (0%)
Query: 512 RTYNASITLQKQLDELTDGDASVPEKILAYNRANRAVAILCNHQRAVPKGHSKSMEALKE 571
RTYNASITLQ+QL ELT D ++P KIL+YNRANRAVAILCNHQRA PK KSM L+
Sbjct: 1 RTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQT 60
Query: 572 KIQAKRDQIDEAEEDLQQASKAAK-RGSVXXXXXXXXXXXXXXXXXXXXXXXXXXXTDRD 630
KI AK++Q+ +A DL+ A AK TDR+
Sbjct: 61 KIDAKKEQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDRE 120
Query: 631 ENKTIALGTSKLNYLDPRISVAWCKKHGVPIEKIYNKTQRDKFRWAIDMAGPDYVF 686
ENK IALGTSKLNYLDPRI+VAWCKK GVPIEKIYNKTQR+KF WAIDMA DY F
Sbjct: 121 ENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF 176
>M27913-1|AAA61208.1| 109|Homo sapiens TOP1 protein.
Length = 109
Score = 114 bits (274), Expect = 1e-24
Identities = 51/60 (85%), Positives = 54/60 (90%)
Query: 627 TDRDENKTIALGTSKLNYLDPRISVAWCKKHGVPIEKIYNKTQRDKFRWAIDMAGPDYVF 686
TDR+ENK IALGTSKLNYLDPRI+VAWCKK GVPIEKIYNKTQR+KF WAIDMA DY F
Sbjct: 50 TDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF 109
>BC027453-1|AAH27453.1| 101|Homo sapiens TOP1MT protein protein.
Length = 101
Score = 103 bits (246), Expect = 3e-21
Identities = 42/60 (70%), Positives = 53/60 (88%)
Query: 627 TDRDENKTIALGTSKLNYLDPRISVAWCKKHGVPIEKIYNKTQRDKFRWAIDMAGPDYVF 686
TD++ENK +ALGTSKLNYLDPRIS+AWCK+ VP+EKIY+KTQR++F WA+ MAG D+ F
Sbjct: 42 TDKEENKQVALGTSKLNYLDPRISIAWCKRFRVPVEKIYSKTQRERFAWALAMAGEDFEF 101
>AY171233-1|AAO13168.1| 754|Homo sapiens protein tyrosine
phosphatase protein.
Length = 754
Score = 36.3 bits (80), Expect = 0.36
Identities = 27/97 (27%), Positives = 51/97 (52%), Gaps = 5/97 (5%)
Query: 504 PGLTAKVFRTYNASITLQKQLDELT-DGDASVPEK--ILAYNRANRAVAILCNHQRAVPK 560
PGL+A++ +T + +T+Q + L D D S P +A + NR + I N Q+ P
Sbjct: 314 PGLSAEIEKTMSEMVTMQLDKELLRHDSDVSNPPNPTAVAADFDNRGM-IFSNEQQFDPL 372
Query: 561 GHSKSMEALKEKIQAKRDQIDEAEEDLQQASKAAKRG 597
+++E L+ KR ++ ++ DL++A ++G
Sbjct: 373 WKRRNVECLQPLTHLKR-RLSYSDSDLKRAENLLEQG 408
>AL360020-3|CAI14621.2| 806|Homo sapiens protein tyrosine
phosphatase domain containing 1 protein.
Length = 806
Score = 36.3 bits (80), Expect = 0.36
Identities = 27/97 (27%), Positives = 51/97 (52%), Gaps = 5/97 (5%)
Query: 504 PGLTAKVFRTYNASITLQKQLDELT-DGDASVPEK--ILAYNRANRAVAILCNHQRAVPK 560
PGL+A++ +T + +T+Q + L D D S P +A + NR + I N Q+ P
Sbjct: 366 PGLSAEIEKTMSEMVTMQLDKELLRHDSDVSNPPNPTAVAADFDNRGM-IFSNEQQFDPL 424
Query: 561 GHSKSMEALKEKIQAKRDQIDEAEEDLQQASKAAKRG 597
+++E L+ KR ++ ++ DL++A ++G
Sbjct: 425 WKRRNVECLQPLTHLKR-RLSYSDSDLKRAENLLEQG 460
>AL360020-2|CAM20720.1| 754|Homo sapiens protein tyrosine
phosphatase domain containing 1 protein.
Length = 754
Score = 36.3 bits (80), Expect = 0.36
Identities = 27/97 (27%), Positives = 51/97 (52%), Gaps = 5/97 (5%)
Query: 504 PGLTAKVFRTYNASITLQKQLDELT-DGDASVPEK--ILAYNRANRAVAILCNHQRAVPK 560
PGL+A++ +T + +T+Q + L D D S P +A + NR + I N Q+ P
Sbjct: 314 PGLSAEIEKTMSEMVTMQLDKELLRHDSDVSNPPNPTAVAADFDNRGM-IFSNEQQFDPL 372
Query: 561 GHSKSMEALKEKIQAKRDQIDEAEEDLQQASKAAKRG 597
+++E L+ KR ++ ++ DL++A ++G
Sbjct: 373 WKRRNVECLQPLTHLKR-RLSYSDSDLKRAENLLEQG 408
>BC118918-1|AAI18919.1| 1302|Homo sapiens cingulin-like 1 protein.
Length = 1302
Score = 35.9 bits (79), Expect = 0.48
Identities = 26/128 (20%), Positives = 54/128 (42%), Gaps = 2/128 (1%)
Query: 471 KNLEIFIENKKDSDDLFDRLNTQTLNEHLKDLMPGLTAKVFRTYNASITLQKQLDELTDG 530
KN+E+ S+ D+ T+ + L++ L + LQ+Q+++L
Sbjct: 801 KNVEVLASRSNTSEQ--DQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGD 858
Query: 531 DASVPEKILAYNRANRAVAILCNHQRAVPKGHSKSMEALKEKIQAKRDQIDEAEEDLQQA 590
+A E + Y R + H R K + AL+ +++A + + + ++ +Q
Sbjct: 859 EAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQL 918
Query: 591 SKAAKRGS 598
S+ K S
Sbjct: 919 SEKLKEES 926
>BC112049-1|AAI12050.1| 1302|Homo sapiens cingulin-like 1 protein.
Length = 1302
Score = 35.9 bits (79), Expect = 0.48
Identities = 26/128 (20%), Positives = 54/128 (42%), Gaps = 2/128 (1%)
Query: 471 KNLEIFIENKKDSDDLFDRLNTQTLNEHLKDLMPGLTAKVFRTYNASITLQKQLDELTDG 530
KN+E+ S+ D+ T+ + L++ L + LQ+Q+++L
Sbjct: 801 KNVEVLASRSNTSEQ--DQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGD 858
Query: 531 DASVPEKILAYNRANRAVAILCNHQRAVPKGHSKSMEALKEKIQAKRDQIDEAEEDLQQA 590
+A E + Y R + H R K + AL+ +++A + + + ++ +Q
Sbjct: 859 EAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQL 918
Query: 591 SKAAKRGS 598
S+ K S
Sbjct: 919 SEKLKEES 926
>BC093827-1|AAH93827.1| 1302|Homo sapiens cingulin-like 1 protein.
Length = 1302
Score = 35.9 bits (79), Expect = 0.48
Identities = 26/128 (20%), Positives = 54/128 (42%), Gaps = 2/128 (1%)
Query: 471 KNLEIFIENKKDSDDLFDRLNTQTLNEHLKDLMPGLTAKVFRTYNASITLQKQLDELTDG 530
KN+E+ S+ D+ T+ + L++ L + LQ+Q+++L
Sbjct: 801 KNVEVLASRSNTSEQ--DQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGD 858
Query: 531 DASVPEKILAYNRANRAVAILCNHQRAVPKGHSKSMEALKEKIQAKRDQIDEAEEDLQQA 590
+A E + Y R + H R K + AL+ +++A + + + ++ +Q
Sbjct: 859 EAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQL 918
Query: 591 SKAAKRGS 598
S+ K S
Sbjct: 919 SEKLKEES 926
>AY274808-1|AAP42073.1| 1302|Homo sapiens KIAA1749 protein protein.
Length = 1302
Score = 35.9 bits (79), Expect = 0.48
Identities = 26/128 (20%), Positives = 54/128 (42%), Gaps = 2/128 (1%)
Query: 471 KNLEIFIENKKDSDDLFDRLNTQTLNEHLKDLMPGLTAKVFRTYNASITLQKQLDELTDG 530
KN+E+ S+ D+ T+ + L++ L + LQ+Q+++L
Sbjct: 801 KNVEVLASRSNTSEQ--DQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGD 858
Query: 531 DASVPEKILAYNRANRAVAILCNHQRAVPKGHSKSMEALKEKIQAKRDQIDEAEEDLQQA 590
+A E + Y R + H R K + AL+ +++A + + + ++ +Q
Sbjct: 859 EAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQL 918
Query: 591 SKAAKRGS 598
S+ K S
Sbjct: 919 SEKLKEES 926
>AB051536-1|BAB21840.2| 1047|Homo sapiens KIAA1749 protein protein.
Length = 1047
Score = 35.9 bits (79), Expect = 0.48
Identities = 26/128 (20%), Positives = 54/128 (42%), Gaps = 2/128 (1%)
Query: 471 KNLEIFIENKKDSDDLFDRLNTQTLNEHLKDLMPGLTAKVFRTYNASITLQKQLDELTDG 530
KN+E+ S+ D+ T+ + L++ L + LQ+Q+++L
Sbjct: 546 KNVEVLASRSNTSEQ--DQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGD 603
Query: 531 DASVPEKILAYNRANRAVAILCNHQRAVPKGHSKSMEALKEKIQAKRDQIDEAEEDLQQA 590
+A E + Y R + H R K + AL+ +++A + + + ++ +Q
Sbjct: 604 EAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQL 663
Query: 591 SKAAKRGS 598
S+ K S
Sbjct: 664 SEKLKEES 671
>BC067120-1|AAH67120.1| 754|Homo sapiens protein tyrosine
phosphatase domain containing 1 protein.
Length = 754
Score = 35.5 bits (78), Expect = 0.63
Identities = 27/97 (27%), Positives = 51/97 (52%), Gaps = 5/97 (5%)
Query: 504 PGLTAKVFRTYNASITLQKQLDELT-DGDASVPEK--ILAYNRANRAVAILCNHQRAVPK 560
PGL+A++ +T + +T+Q + L D D S P +A + NR + I N Q+ P
Sbjct: 314 PGLSAEIEKTMSEMVTMQLDKELLRHDSDFSNPPNPTAVAADFDNRGM-IFSNEQQFDPL 372
Query: 561 GHSKSMEALKEKIQAKRDQIDEAEEDLQQASKAAKRG 597
+++E L+ KR ++ ++ DL++A ++G
Sbjct: 373 WKRRNVECLQPLTHLKR-RLSYSDSDLKRAENLLEQG 408
>AK027863-1|BAB55415.1| 612|Homo sapiens protein ( Homo sapiens
cDNA FLJ14957 fis, clone PLACE4000009, weakly similar to
MYOSIN HEAVY CHAIN, NONMUSCLE TYPE B. ).
Length = 612
Score = 35.5 bits (78), Expect = 0.63
Identities = 26/128 (20%), Positives = 54/128 (42%), Gaps = 2/128 (1%)
Query: 471 KNLEIFIENKKDSDDLFDRLNTQTLNEHLKDLMPGLTAKVFRTYNASITLQKQLDELTDG 530
KN+E+ S+ D+ T+ + L++ L + LQ+Q+++L
Sbjct: 111 KNVEVLASRSNTSEQ--DQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGD 168
Query: 531 DASVPEKILAYNRANRAVAILCNHQRAVPKGHSKSMEALKEKIQAKRDQIDEAEEDLQQA 590
+A E + Y R + H R K + AL+ +++A + + + ++ +Q
Sbjct: 169 EAKAKETLKKYEGEIRQLEEALVHVRKEEKEAVSARRALENELEAAQGNLSQTTQEQKQL 228
Query: 591 SKAAKRGS 598
S+ K S
Sbjct: 229 SEKLKEES 236
>AY610514-1|AAT37906.1| 1302|Homo sapiens paracingulin protein.
Length = 1302
Score = 34.3 bits (75), Expect = 1.5
Identities = 25/128 (19%), Positives = 53/128 (41%), Gaps = 2/128 (1%)
Query: 471 KNLEIFIENKKDSDDLFDRLNTQTLNEHLKDLMPGLTAKVFRTYNASITLQKQLDELTDG 530
KN+E+ S+ D+ T+ + L++ L + LQ+Q+++L
Sbjct: 801 KNVEVLASRSNTSEQ--DQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGD 858
Query: 531 DASVPEKILAYNRANRAVAILCNHQRAVPKGHSKSMEALKEKIQAKRDQIDEAEEDLQQA 590
+A E + Y R + H R K + AL+ +++ + + + ++ +Q
Sbjct: 859 EAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEGAQGNLSQTTQEQKQL 918
Query: 591 SKAAKRGS 598
S+ K S
Sbjct: 919 SEKLKEES 926
>AY528715-1|AAT44400.1| 1016|Homo sapiens antigen MU-RMS-40.16A
protein.
Length = 1016
Score = 33.5 bits (73), Expect = 2.5
Identities = 30/135 (22%), Positives = 62/135 (45%), Gaps = 5/135 (3%)
Query: 462 EVPVEKRVFKNLEIFIENKKDSDDLFDRLNTQTLNEHLKDLMPGLTAKVFRTYNASITLQ 521
E+ VE++V + +E+ E +K+++ + R Q L + L+ + L + + Q
Sbjct: 384 EIDVEEQVSRFIEL--EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQ 441
Query: 522 KQLDELTDGDASVPEKILAYNRANRAVAILCNHQRAVPKGHSK---SMEALKEKIQAKRD 578
+++ +L VP R V L NH + S+ S E L+ IQ + +
Sbjct: 442 QEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNE 501
Query: 579 QIDEAEEDLQQASKA 593
+I++ E +++ +A
Sbjct: 502 EIEKLEFRVRELEQA 516
>AJ131693-1|CAB40713.1| 3908|Homo sapiens AKAP450 protein protein.
Length = 3908
Score = 33.5 bits (73), Expect = 2.5
Identities = 30/135 (22%), Positives = 62/135 (45%), Gaps = 5/135 (3%)
Query: 462 EVPVEKRVFKNLEIFIENKKDSDDLFDRLNTQTLNEHLKDLMPGLTAKVFRTYNASITLQ 521
E+ VE++V + +E+ E +K+++ + R Q L + L+ + L + + Q
Sbjct: 2028 EIDVEEQVSRFIEL--EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQ 2085
Query: 522 KQLDELTDGDASVPEKILAYNRANRAVAILCNHQRAVPKGHSK---SMEALKEKIQAKRD 578
+++ +L VP R V L NH + S+ S E L+ IQ + +
Sbjct: 2086 QEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNE 2145
Query: 579 QIDEAEEDLQQASKA 593
+I++ E +++ +A
Sbjct: 2146 EIEKLEFRVRELEQA 2160
>AJ010770-1|CAA09361.1| 3911|Homo sapiens Hyperion protein protein.
Length = 3911
Score = 33.5 bits (73), Expect = 2.5
Identities = 30/135 (22%), Positives = 62/135 (45%), Gaps = 5/135 (3%)
Query: 462 EVPVEKRVFKNLEIFIENKKDSDDLFDRLNTQTLNEHLKDLMPGLTAKVFRTYNASITLQ 521
E+ VE++V + +E+ E +K+++ + R Q L + L+ + L + + Q
Sbjct: 2039 EIDVEEQVSRFIEL--EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQ 2096
Query: 522 KQLDELTDGDASVPEKILAYNRANRAVAILCNHQRAVPKGHSK---SMEALKEKIQAKRD 578
+++ +L VP R V L NH + S+ S E L+ IQ + +
Sbjct: 2097 QEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNE 2156
Query: 579 QIDEAEEDLQQASKA 593
+I++ E +++ +A
Sbjct: 2157 EIEKLEFRVRELEQA 2171
>AF083037-1|AAD22767.1| 3595|Homo sapiens A-kinase anchoring protein
AKAP350 protein.
Length = 3595
Score = 33.5 bits (73), Expect = 2.5
Identities = 30/135 (22%), Positives = 62/135 (45%), Gaps = 5/135 (3%)
Query: 462 EVPVEKRVFKNLEIFIENKKDSDDLFDRLNTQTLNEHLKDLMPGLTAKVFRTYNASITLQ 521
E+ VE++V + +E+ E +K+++ + R Q L + L+ + L + + Q
Sbjct: 1715 EIDVEEQVSRFIEL--EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQ 1772
Query: 522 KQLDELTDGDASVPEKILAYNRANRAVAILCNHQRAVPKGHSK---SMEALKEKIQAKRD 578
+++ +L VP R V L NH + S+ S E L+ IQ + +
Sbjct: 1773 QEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNE 1832
Query: 579 QIDEAEEDLQQASKA 593
+I++ E +++ +A
Sbjct: 1833 EIEKLEFRVRELEQA 1847
>AC004013-1|AAB96867.2| 2058|Homo sapiens unknown protein.
Length = 2058
Score = 33.5 bits (73), Expect = 2.5
Identities = 30/135 (22%), Positives = 62/135 (45%), Gaps = 5/135 (3%)
Query: 462 EVPVEKRVFKNLEIFIENKKDSDDLFDRLNTQTLNEHLKDLMPGLTAKVFRTYNASITLQ 521
E+ VE++V + +E+ E +K+++ + R Q L + L+ + L + + Q
Sbjct: 237 EIDVEEQVSRFIEL--EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQ 294
Query: 522 KQLDELTDGDASVPEKILAYNRANRAVAILCNHQRAVPKGHSK---SMEALKEKIQAKRD 578
+++ +L VP R V L NH + S+ S E L+ IQ + +
Sbjct: 295 QEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNE 354
Query: 579 QIDEAEEDLQQASKA 593
+I++ E +++ +A
Sbjct: 355 EIEKLEFRVRELEQA 369
>Z82215-4|CAB05105.1| 1960|Homo sapiens myosin, heavy chain 9,
non-muscle protein.
Length = 1960
Score = 33.1 bits (72), Expect = 3.4
Identities = 26/133 (19%), Positives = 60/133 (45%), Gaps = 8/133 (6%)
Query: 472 NLEIFIENKKDSDDLFDRLNTQTLNEHLKDLMPGLTAKVFRTYNASIT--------LQKQ 523
N ++ +E + R + N+ LK + + V Y ASIT L++Q
Sbjct: 1763 NTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQ 1822
Query: 524 LDELTDGDASVPEKILAYNRANRAVAILCNHQRAVPKGHSKSMEALKEKIQAKRDQIDEA 583
LD T + +++ + + V + + +R + + + +++ + Q++EA
Sbjct: 1823 LDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEA 1882
Query: 584 EEDLQQASKAAKR 596
EE+ Q+A+ + ++
Sbjct: 1883 EEEAQRANASRRK 1895
>X90568-1|CAA62188.1|26926|Homo sapiens titin protein.
Length = 26926
Score = 33.1 bits (72), Expect = 3.4
Identities = 20/74 (27%), Positives = 35/74 (47%), Gaps = 4/74 (5%)
Query: 311 KDSKIPKPPSGHKWREVRHDN-TVTWLASWTENVQQQAKYVMLNPSSKLKGEKDWQKYET 369
K ++ P PP + D+ ++TWL + + YV+ + KG+K+W K
Sbjct: 19873 KITEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVV---EALEKGQKNWVKCAV 19929
Query: 370 ARKLHKCIDKIREN 383
A+ H + +REN
Sbjct: 19930 AKSTHHVVSGLREN 19943
>CR456526-1|CAG30412.1| 1960|Homo sapiens MYH9 protein.
Length = 1960
Score = 33.1 bits (72), Expect = 3.4
Identities = 26/133 (19%), Positives = 60/133 (45%), Gaps = 8/133 (6%)
Query: 472 NLEIFIENKKDSDDLFDRLNTQTLNEHLKDLMPGLTAKVFRTYNASIT--------LQKQ 523
N ++ +E + R + N+ LK + + V Y ASIT L++Q
Sbjct: 1763 NTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQ 1822
Query: 524 LDELTDGDASVPEKILAYNRANRAVAILCNHQRAVPKGHSKSMEALKEKIQAKRDQIDEA 583
LD T + +++ + + V + + +R + + + +++ + Q++EA
Sbjct: 1823 LDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEA 1882
Query: 584 EEDLQQASKAAKR 596
EE+ Q+A+ + ++
Sbjct: 1883 EEEAQRANASRRK 1895
>AK131080-1|BAC85130.1| 563|Homo sapiens FLJ00279 protein protein.
Length = 563
Score = 33.1 bits (72), Expect = 3.4
Identities = 26/133 (19%), Positives = 60/133 (45%), Gaps = 8/133 (6%)
Query: 472 NLEIFIENKKDSDDLFDRLNTQTLNEHLKDLMPGLTAKVFRTYNASIT--------LQKQ 523
N ++ +E + R + N+ LK + + V Y ASIT L++Q
Sbjct: 366 NTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQ 425
Query: 524 LDELTDGDASVPEKILAYNRANRAVAILCNHQRAVPKGHSKSMEALKEKIQAKRDQIDEA 583
LD T + +++ + + V + + +R + + + +++ + Q++EA
Sbjct: 426 LDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEA 485
Query: 584 EEDLQQASKAAKR 596
EE+ Q+A+ + ++
Sbjct: 486 EEEAQRANASRRK 498
>AJ277892-2|CAD12456.1|30017|Homo sapiens Titin protein.
Length = 30000
Score = 33.1 bits (72), Expect = 3.4
Identities = 20/74 (27%), Positives = 35/74 (47%), Gaps = 4/74 (5%)
Query: 311 KDSKIPKPPSGHKWREVRHDN-TVTWLASWTENVQQQAKYVMLNPSSKLKGEKDWQKYET 369
K ++ P PP + D+ ++TWL + + YV+ + KG+K+W K
Sbjct: 27297 KITEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVV---EALEKGQKNWVKCAV 27353
Query: 370 ARKLHKCIDKIREN 383
A+ H + +REN
Sbjct: 27354 AKSTHHVVSGLREN 27367
>AJ277892-1|CAD12455.1|26926|Homo sapiens N2B-Titin Isoform protein.
Length = 26926
Score = 33.1 bits (72), Expect = 3.4
Identities = 20/74 (27%), Positives = 35/74 (47%), Gaps = 4/74 (5%)
Query: 311 KDSKIPKPPSGHKWREVRHDN-TVTWLASWTENVQQQAKYVMLNPSSKLKGEKDWQKYET 369
K ++ P PP + D+ ++TWL + + YV+ + KG+K+W K
Sbjct: 19873 KITEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVV---EALEKGQKNWVKCAV 19929
Query: 370 ARKLHKCIDKIREN 383
A+ H + +REN
Sbjct: 19930 AKSTHHVVSGLREN 19943
>AB191263-1|BAD52439.1| 1960|Homo sapiens non-muscle myosin heavy
polypeptide 9 protein.
Length = 1960
Score = 33.1 bits (72), Expect = 3.4
Identities = 26/133 (19%), Positives = 60/133 (45%), Gaps = 8/133 (6%)
Query: 472 NLEIFIENKKDSDDLFDRLNTQTLNEHLKDLMPGLTAKVFRTYNASIT--------LQKQ 523
N ++ +E + R + N+ LK + + V Y ASIT L++Q
Sbjct: 1763 NTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQ 1822
Query: 524 LDELTDGDASVPEKILAYNRANRAVAILCNHQRAVPKGHSKSMEALKEKIQAKRDQIDEA 583
LD T + +++ + + V + + +R + + + +++ + Q++EA
Sbjct: 1823 LDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEA 1882
Query: 584 EEDLQQASKAAKR 596
EE+ Q+A+ + ++
Sbjct: 1883 EEEAQRANASRRK 1895
>AB019691-1|BAA78718.1| 3899|Homo sapiens Centrosome- and
Golgi-localized PKN-associated protein (CG-NAP) protein.
Length = 3899
Score = 33.1 bits (72), Expect = 3.4
Identities = 31/128 (24%), Positives = 58/128 (45%), Gaps = 6/128 (4%)
Query: 462 EVPVEKRVFKNLEIFIENKKDSDDLFDRLNTQTLNEHLKDLMPGLTAKVFRTYNASITLQ 521
E+ VE++V + +E+ E +K+++ + R Q L + L+ + L + + Q
Sbjct: 2027 EIDVEEQVSRFIEL--EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQ 2084
Query: 522 KQLDELTDGDASVPEKILAYNRANRAVAILCNHQRAVPKGHSKSMEALKEKIQAKRDQID 581
+++ +L VP R V L NH + + K E L K Q +RD I
Sbjct: 2085 QEIQKLEQQLKVVPRFQPISEHQTREVEQLANH---LKEKTDKCSELLLSKEQLQRD-IQ 2140
Query: 582 EAEEDLQQ 589
E E++++
Sbjct: 2141 ERNEEIEK 2148
>AL832639-1|CAD89954.1| 1331|Homo sapiens hypothetical protein
protein.
Length = 1331
Score = 32.7 bits (71), Expect = 4.4
Identities = 27/131 (20%), Positives = 58/131 (44%), Gaps = 8/131 (6%)
Query: 472 NLEIFIENKKDSDDLFDRLNTQTLNEHLKDLMPGLTAKVFRTYNASIT--------LQKQ 523
N ++ +E + R + N+ LK + + V Y ASIT L++Q
Sbjct: 1185 NTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQ 1244
Query: 524 LDELTDGDASVPEKILAYNRANRAVAILCNHQRAVPKGHSKSMEALKEKIQAKRDQIDEA 583
LD T + +++ + + V + + +R + + + +++ + Q++EA
Sbjct: 1245 LDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEA 1304
Query: 584 EEDLQQASKAA 594
EE+ Q+A+ A
Sbjct: 1305 EEEAQRATPPA 1315
>M31013-1|AAA36349.1| 1247|Homo sapiens protein ( Human nonmuscle
myosin heavy chain (NMHC) mRNA, 3' end. ).
Length = 1247
Score = 32.3 bits (70), Expect = 5.9
Identities = 24/116 (20%), Positives = 54/116 (46%), Gaps = 8/116 (6%)
Query: 489 RLNTQTLNEHLKDLMPGLTAKVFRTYNASIT--------LQKQLDELTDGDASVPEKILA 540
R + N+ LK + + V Y ASIT L++QLD T + +++
Sbjct: 1067 RQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRR 1126
Query: 541 YNRANRAVAILCNHQRAVPKGHSKSMEALKEKIQAKRDQIDEAEEDLQQASKAAKR 596
+ + V + + +R + + + +++ + Q++EAEE+ Q+A+ + ++
Sbjct: 1127 TEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRK 1182
>BC060802-1|AAH60802.1| 487|Homo sapiens histamine receptor H1
protein.
Length = 487
Score = 31.9 bits (69), Expect = 7.8
Identities = 12/35 (34%), Positives = 21/35 (60%)
Query: 414 NEKDDEQADTVGCCSLRVEHIQLHKEKDGKEYVVV 448
+++DD + D + C L +EH+Q E ++YV V
Sbjct: 290 SQEDDREVDKLYCFPLDIEHMQAAAEGSSRDYVAV 324
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.315 0.133 0.402
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 81,376,264
Number of Sequences: 224733
Number of extensions: 3300661
Number of successful extensions: 7061
Number of sequences better than 10.0: 42
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 6977
Number of HSP's gapped (non-prelim): 97
length of query: 686
length of database: 73,234,838
effective HSP length: 95
effective length of query: 591
effective length of database: 51,885,203
effective search space: 30664154973
effective search space used: 30664154973
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 42 (22.0 bits)
S2: 69 (31.9 bits)
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