Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002841-TA|BGIBMGA002841-PA|IPR001315|Caspase
Recruitment, IPR002138|Peptidase C14, caspase non-catalytic subunit
p10, IPR001309|Caspase, p20 subunit, IPR011600|Peptidase C14, caspase
catalytic, IPR002398|Peptidase C14, caspase precursor p45,
IPR011029|DEATH-like
(410 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_UPI00015B59A2 Cluster: PREDICTED: similar to ecdysone-i... 167 6e-40
UniRef50_Q4SC67 Cluster: Chromosome undetermined SCAF14659, whol... 155 2e-36
UniRef50_Q9XYF4 Cluster: Caspase Nc precursor (EC 3.4.22.-) (NED... 150 6e-35
UniRef50_Q16PQ5 Cluster: Ecdysone-inducible caspase, putative; n... 146 7e-34
UniRef50_Q4V923 Cluster: Zgc:101776 protein; n=8; Clupeocephala|... 140 8e-32
UniRef50_UPI0000D57084 Cluster: PREDICTED: similar to CG8091-PA;... 137 4e-31
UniRef50_Q90WU0 Cluster: Caspase 9; n=2; Gallus gallus|Rep: Casp... 118 2e-25
UniRef50_UPI0000586459 Cluster: PREDICTED: similar to caspase-3,... 111 4e-23
UniRef50_P42575 Cluster: Caspase-2 precursor (EC 3.4.22.55) (CAS... 106 1e-21
UniRef50_P55211 Cluster: Caspase-9 precursor (EC 3.4.22.62) (CAS... 105 2e-21
UniRef50_P42573 Cluster: Cell death protein 3 precursor (EC 3.4.... 99 2e-19
UniRef50_P55212 Cluster: Caspase-6 precursor (EC 3.4.22.59) (CAS... 99 2e-19
UniRef50_O01382 Cluster: Caspase precursor (EC 3.4.22.-) (drICE)... 98 4e-19
UniRef50_UPI0000E47F37 Cluster: PREDICTED: similar to caspase-3,... 95 2e-18
UniRef50_UPI0000E49D20 Cluster: PREDICTED: hypothetical protein;... 95 3e-18
UniRef50_UPI00015B57EE Cluster: PREDICTED: similar to ENSANGP000... 91 5e-17
UniRef50_Q6E5N8 Cluster: Caspase 8; n=1; Ictalurus punctatus|Rep... 90 8e-17
UniRef50_Q8I6Y2 Cluster: Caspase-3; n=2; Geodia cydonium|Rep: Ca... 87 1e-15
UniRef50_Q7Q1E0 Cluster: ENSANGP00000015118; n=2; Culicidae|Rep:... 86 1e-15
UniRef50_UPI0000E45DDA Cluster: PREDICTED: similar to caspase 3;... 86 2e-15
UniRef50_Q0Z8U7 Cluster: Caspase-8; n=1; Haemaphysalis longicorn... 86 2e-15
UniRef50_Q7Q803 Cluster: ENSANGP00000021367; n=6; Anopheles gamb... 85 2e-15
UniRef50_Q504J1 Cluster: Caspase b; n=7; Danio rerio|Rep: Caspas... 85 3e-15
UniRef50_UPI00015B4D75 Cluster: PREDICTED: similar to CG7788-PA;... 83 1e-14
UniRef50_A2BGE2 Cluster: Novel protein similar to caspase 8; n=4... 83 1e-14
UniRef50_P31944 Cluster: Caspase-14 precursor (EC 3.4.22.-) (CAS... 83 1e-14
UniRef50_Q5C0Y4 Cluster: SJCHGC07329 protein; n=1; Schistosoma j... 81 5e-14
UniRef50_Q3HL92 Cluster: Caspase-like protein; n=6; Eumetazoa|Re... 81 7e-14
UniRef50_UPI0000519DFF Cluster: PREDICTED: similar to Caspase pr... 80 9e-14
UniRef50_Q4FJK5 Cluster: Casp9 protein; n=20; Eutheria|Rep: Casp... 80 9e-14
UniRef50_UPI0000ECB87F Cluster: Caspase-10 precursor (EC 3.4.22.... 79 2e-13
UniRef50_UPI0000D55B5F Cluster: PREDICTED: similar to Caspase pr... 79 2e-13
UniRef50_A7S9L1 Cluster: Predicted protein; n=1; Nematostella ve... 79 2e-13
UniRef50_UPI0000E48555 Cluster: PREDICTED: similar to Lice2 cyst... 79 3e-13
UniRef50_Q0WYJ4 Cluster: Caspase 10; n=4; Percomorpha|Rep: Caspa... 77 6e-13
UniRef50_Q8ITP2 Cluster: AmphiCASP-6; n=2; Chordata|Rep: AmphiCA... 77 6e-13
UniRef50_Q9Y1U6 Cluster: Cell death protein CED-3; n=1; Pristion... 77 1e-12
UniRef50_O42284 Cluster: Caspase-1; n=3; Gallus gallus|Rep: Casp... 76 1e-12
UniRef50_P55865 Cluster: Caspase-1-A precursor; n=3; Xenopus|Rep... 76 2e-12
UniRef50_Q92851-2 Cluster: Isoform B of Q92851 ; n=9; Mammalia|R... 75 5e-12
UniRef50_Q92851 Cluster: Caspase-10 precursor (EC 3.4.22.63) (CA... 75 5e-12
UniRef50_A7S119 Cluster: Predicted protein; n=1; Nematostella ve... 74 6e-12
UniRef50_UPI0000587146 Cluster: PREDICTED: similar to caspase Xa... 74 8e-12
UniRef50_A7SPA7 Cluster: Predicted protein; n=1; Nematostella ve... 73 1e-11
UniRef50_Q7ZXD2 Cluster: MGC53258 protein; n=3; Xenopus|Rep: MGC... 73 2e-11
UniRef50_Q9IB62 Cluster: Caspase-10; n=5; Xenopus|Rep: Caspase-1... 72 2e-11
UniRef50_Q0PKX0 Cluster: Caspase Xa; n=4; Danio rerio|Rep: Caspa... 72 3e-11
UniRef50_Q3T2L0 Cluster: Caspase-15; n=11; Theria|Rep: Caspase-1... 72 3e-11
UniRef50_Q17FE3 Cluster: Caspase-1; n=3; Endopterygota|Rep: Casp... 72 3e-11
UniRef50_Q5DD62 Cluster: SJCHGC00800 protein; n=3; Schistosoma j... 71 4e-11
UniRef50_Q07BT4 Cluster: Caspase-1; n=2; Percomorpha|Rep: Caspas... 70 1e-10
UniRef50_A7S4V9 Cluster: Predicted protein; n=2; Nematostella ve... 69 2e-10
UniRef50_P55210 Cluster: Caspase-7 precursor (EC 3.4.22.60) (CAS... 68 4e-10
UniRef50_Q98UI8 Cluster: Caspase-3; n=4; Chordata|Rep: Caspase-3... 68 5e-10
UniRef50_Q5E9C1 Cluster: Caspase-4 precursor (EC 3.4.22.57) (CAS... 68 5e-10
UniRef50_UPI0000E47913 Cluster: PREDICTED: similar to cysteine p... 67 9e-10
UniRef50_A3QVU6 Cluster: Initiator caspase; n=3; Culicidae|Rep: ... 67 9e-10
UniRef50_UPI0000F1EBE3 Cluster: PREDICTED: similar to caspase 10... 66 2e-09
UniRef50_P51878 Cluster: Caspase-5 precursor (EC 3.4.22.58) (CAS... 66 2e-09
UniRef50_P49662 Cluster: Caspase-4 precursor (EC 3.4.22.57) (CAS... 66 2e-09
UniRef50_Q14790 Cluster: Caspase-8 precursor (EC 3.4.22.61) (CAS... 65 3e-09
UniRef50_P29466 Cluster: Caspase-1 precursor (EC 3.4.22.36) (CAS... 65 3e-09
UniRef50_UPI00015553DC Cluster: PREDICTED: similar to caspase-15... 64 5e-09
UniRef50_UPI0000661247 Cluster: Homolog of Brachydanio rerio "Ca... 64 5e-09
UniRef50_UPI0000F2DFE7 Cluster: PREDICTED: similar to apoptotic ... 64 6e-09
UniRef50_UPI0000F21D96 Cluster: PREDICTED: hypothetical protein,... 64 8e-09
UniRef50_P29466-2 Cluster: Isoform Beta of P29466 ; n=11; Theria... 62 2e-08
UniRef50_Q6KF63 Cluster: Caspase 10; n=3; Catarrhini|Rep: Caspas... 62 2e-08
UniRef50_Q5D0W5 Cluster: Caspase 3C; n=2; Hydra vulgaris|Rep: Ca... 62 3e-08
UniRef50_UPI0000E472FD Cluster: PREDICTED: similar to caspase 8;... 62 3e-08
UniRef50_UPI0000F2CF2D Cluster: PREDICTED: similar to evolutiona... 61 6e-08
UniRef50_UPI0000F2CF2E Cluster: PREDICTED: similar to caspase 12... 60 8e-08
UniRef50_Q9TZP6 Cluster: Caspase-related protein 1B; n=3; Caenor... 60 1e-07
UniRef50_Q9NHF9 Cluster: Caspase 6-like protein BG2; n=3; Sophop... 60 1e-07
UniRef50_UPI0000D56041 Cluster: PREDICTED: similar to CG7486-PB,... 59 2e-07
UniRef50_Q9GV89 Cluster: Caspase 3A; n=1; Hydra vulgaris|Rep: Ca... 59 2e-07
UniRef50_Q56VC9 Cluster: Caspase-8; n=3; Euteleostei|Rep: Caspas... 58 3e-07
UniRef50_Q4SNC6 Cluster: Chromosome 8 SCAF14543, whole genome sh... 58 3e-07
UniRef50_Q09HM6 Cluster: Caspase-8; n=1; Molgula tectiformis|Rep... 58 3e-07
UniRef50_Q7Q802 Cluster: ENSANGP00000021365; n=4; Cellia|Rep: EN... 58 6e-07
UniRef50_Q9Y055 Cluster: Caspase-related protein 2A; n=3; Caenor... 57 7e-07
UniRef50_Q4RG79 Cluster: Chromosome 2 SCAF15106, whole genome sh... 57 1e-06
UniRef50_Q4JQQ0 Cluster: Initiator caspase; n=2; Gallus gallus|R... 56 1e-06
UniRef50_Q7QKT2 Cluster: ENSANGP00000015505; n=3; Anopheles gamb... 56 1e-06
UniRef50_Q9I9L7 Cluster: Caspase; n=2; Danio rerio|Rep: Caspase ... 55 3e-06
UniRef50_A5JSK5 Cluster: Cysteine protease; n=2; Eukaryota|Rep: ... 54 5e-06
UniRef50_P29466-4 Cluster: Isoform Delta of P29466 ; n=2; Euarch... 54 9e-06
UniRef50_Q5BLH4 Cluster: Caspase c; n=4; Danio rerio|Rep: Caspas... 53 1e-05
UniRef50_UPI0001554FA5 Cluster: PREDICTED: similar to initiator ... 53 2e-05
UniRef50_Q16FR8 Cluster: Caspase-1; n=1; Aedes aegypti|Rep: Casp... 52 3e-05
UniRef50_Q0Z855 Cluster: Caspase-2; n=1; Haemaphysalis longicorn... 52 3e-05
UniRef50_Q4S1R8 Cluster: Chromosome undetermined SCAF14764, whol... 52 4e-05
UniRef50_Q5JRU9 Cluster: Caspase 9, apoptosis-related cysteine p... 52 4e-05
UniRef50_A4VB10 Cluster: Putative uncharacterized protein; n=1; ... 51 6e-05
UniRef50_UPI0000F2097E Cluster: PREDICTED: hypothetical protein;... 50 1e-04
UniRef50_UPI0000E48C15 Cluster: PREDICTED: similar to caspase 8;... 50 1e-04
UniRef50_A6NFM5 Cluster: Uncharacterized protein ENSP00000371619... 50 1e-04
UniRef50_P55213 Cluster: Caspase-3 precursor (EC 3.4.22.56) (CAS... 49 2e-04
UniRef50_Q2TM51 Cluster: Caspase; n=3; Penaeidae|Rep: Caspase - ... 49 3e-04
UniRef50_Q9IB64 Cluster: Caspase-8; n=1; Xenopus laevis|Rep: Cas... 48 3e-04
UniRef50_Q8I749 Cluster: Caspase-related protein; n=1; Suberites... 48 3e-04
UniRef50_O08736 Cluster: Caspase-12 precursor; n=12; Eutheria|Re... 48 3e-04
UniRef50_UPI00006A1E20 Cluster: Caspase-9 precursor (EC 3.4.22.6... 48 6e-04
UniRef50_Q9I8J3 Cluster: Caspase-8; n=11; Danio rerio|Rep: Caspa... 48 6e-04
UniRef50_Q69HP8 Cluster: Caspase-1-like; n=1; Ciona intestinalis... 48 6e-04
UniRef50_UPI0000E4A029 Cluster: PREDICTED: similar to PDZ domain... 47 0.001
UniRef50_UPI0000F2CF2F Cluster: PREDICTED: similar to caspase 12... 46 0.001
UniRef50_Q8JIS8 Cluster: Caspase 3A; n=3; Euteleostomi|Rep: Casp... 46 0.001
UniRef50_Q2HZ04 Cluster: ICE-5; n=3; Bombyx mori|Rep: ICE-5 - Bo... 46 0.001
UniRef50_UPI0000E4699D Cluster: PREDICTED: similar to caspase 2;... 46 0.002
UniRef50_UPI000065FEF6 Cluster: Homolog of Ictalurus punctatus "... 45 0.004
UniRef50_A7SYJ3 Cluster: Predicted protein; n=1; Nematostella ve... 45 0.004
UniRef50_Q28GK9 Cluster: Novel protein; n=1; Xenopus tropicalis|... 44 0.006
UniRef50_UPI0000F1EFFE Cluster: PREDICTED: hypothetical protein;... 44 0.007
UniRef50_Q7QGN0 Cluster: ENSANGP00000018113; n=4; Anopheles gamb... 44 0.010
UniRef50_A1L2P4 Cluster: LOC100036910 protein; n=1; Xenopus laev... 43 0.017
UniRef50_UPI0000E25016 Cluster: PREDICTED: similar to caspase 14... 42 0.029
UniRef50_A7M858 Cluster: Caspase-like protease; n=1; Suberites d... 41 0.051
UniRef50_UPI0000E82482 Cluster: PREDICTED: hypothetical protein;... 41 0.068
UniRef50_Q8IRY7 Cluster: Caspase-8 precursor (EC 3.4.22.61) (Dea... 40 0.090
UniRef50_UPI0000DB7195 Cluster: PREDICTED: similar to caspase 10... 40 0.12
UniRef50_Q28XB8 Cluster: GA14832-PA; n=1; Drosophila pseudoobscu... 40 0.12
UniRef50_UPI0000F2DFE8 Cluster: PREDICTED: similar to initiator ... 39 0.21
UniRef50_Q5K5C1 Cluster: Caspase 7-like protein; n=1; Spodoptera... 39 0.21
UniRef50_Q98IJ6 Cluster: Mll2372 protein; n=1; Mesorhizobium lot... 39 0.27
UniRef50_A4KXL9 Cluster: Caspase-like protein; n=1; Heliothis vi... 38 0.48
UniRef50_Q1JPW7 Cluster: Cflar protein; n=3; Danio rerio|Rep: Cf... 36 1.9
UniRef50_UPI0000587370 Cluster: PREDICTED: similar to caspase 8,... 36 2.6
UniRef50_Q89M43 Cluster: Blr4350 protein; n=9; Bradyrhizobiaceae... 35 3.4
UniRef50_A7SXL6 Cluster: Predicted protein; n=1; Nematostella ve... 34 5.9
UniRef50_Q9TW65 Cluster: Dystrophin-1; n=4; root|Rep: Dystrophin... 34 5.9
UniRef50_A7RTN5 Cluster: Predicted protein; n=2; Nematostella ve... 34 7.8
UniRef50_A2G8I8 Cluster: Putative uncharacterized protein; n=1; ... 34 7.8
UniRef50_Q5X4J1 Cluster: [Protein-PII] uridylyltransferase; n=4;... 34 7.8
>UniRef50_UPI00015B59A2 Cluster: PREDICTED: similar to
ecdysone-inducible caspase, putative; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to
ecdysone-inducible caspase, putative - Nasonia
vitripennis
Length = 438
Score = 167 bits (405), Expect = 6e-40
Identities = 127/442 (28%), Positives = 211/442 (47%), Gaps = 45/442 (10%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIE-PYRDTSITPRERKRILYR 59
M+ + ++ I + L+ D+ + L E V+++ + P +++ E R +
Sbjct: 1 MELKDRQKIDHLCNQLLPSLDIKRLWPKLLEHKVYNRDDVNIPNWQKNLSSLETVRDICC 60
Query: 60 EITRRGPQAFTMLLEALREMGHWDLVRDLDP-------NSPLQLRARRPVLPPTRQGSDA 112
I RGP+A+ L+ +LR+ H +V L+ N+ +PP +
Sbjct: 61 TIKTRGPRAYAALIASLRQSDHQHVVDQLENDGASSSVNNANNNTTTEDNVPPVNDSLEN 120
Query: 113 XXXXXXXNSSEPVAIPCFH-------------VKKSTHFFEDDVSRDIQLYRTRSRKRGV 159
++ + + +H VKK+ F ++ SR I+ Y RS RG+
Sbjct: 121 SLESASNSNYQEHSEDDYHTKLYTEYEPLVIKVKKAELFRDEPQSRGIERYAMRSNPRGL 180
Query: 160 LVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV- 218
+++ + I + I R D D L LF E+GF V+ Y+NLT + + + + S +
Sbjct: 181 VLMITNIDY--KILDRRPSAKYDEDNLTNLFEEMGFRVIKYKNLTGNEIKKKVREFSQMK 238
Query: 219 -LAGYECVFLVVSSHGHERRYSSDTDIRCSD---GKFISLYA--IVDYFNNRKLPNFTDL 272
LA + VF+++SSHG R +T+I+ D + S++ I+D F + P+ +
Sbjct: 239 ELARVDSVFVIISSHGSGERGKQETEIQGIDYMLSTYESIFCTDIIDNFTAMQCPSLINK 298
Query: 273 PKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNI 332
PK+FIFQ CRG+ A + A D V YS+
Sbjct: 299 PKIFIFQTCRGDKHQ-------QAVVSRFATDAVVTKEASSDSHKPFGVSMRN---YSDT 348
Query: 333 LIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLR-LRFGR--- 388
+IA +TLPG++S+RD GSW+IQ+LCEVF A + HV +LFT+ D R++ LR G
Sbjct: 349 IIAYATLPGYVSYRDTHNGSWFIQILCEVFMNYACEKHVQDLFTMTDGRIKNLRTGSDQC 408
Query: 389 QTSSVDRWGFNNKLYLHPGLYE 410
QT SV GF++ YL+PGL++
Sbjct: 409 QTLSVINEGFHH-CYLNPGLFD 429
>UniRef50_Q4SC67 Cluster: Chromosome undetermined SCAF14659, whole
genome shotgun sequence; n=2; Deuterostomia|Rep:
Chromosome undetermined SCAF14659, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 445
Score = 155 bits (377), Expect = 2e-36
Identities = 119/382 (31%), Positives = 174/382 (45%), Gaps = 18/382 (4%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M+E HKK +QRN +LV + ++ L EKGVF+ MI+ + S R++ R L R+
Sbjct: 1 MEERHKKILQRNRINLVSELEPLNLYDGLIEKGVFTHDMIDEIK-CSGARRDQARQLVRD 59
Query: 61 ITRRGPQAFTMLLEALREMGHWDLVRDLDPNSP-LQLRARRPVLPPTRQGSDAXXXXXXX 119
+ RG +AF LE L+E G+ L L +P +Q++ P+
Sbjct: 60 LETRGSRAFPAFLECLKETGYHSLAELLQNGAPTVQIQPPTPIPVDRPVIQPLPISPPLV 119
Query: 120 NSSEPVA-IPCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIE-PNRD 177
EPV+ +P FF + Q YR + G ++ + + F NR+
Sbjct: 120 PPEEPVSPVPKPSTPGRASFFL--LPFVCQSYRMEANPLGHCLIINNVEFEPKSGLSNRN 177
Query: 178 GVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGHER 236
G NVDCD+L+ F + F V NL Q R L +S V + Y+C +V+ SHG E
Sbjct: 178 GSNVDCDRLERRFKALNFTVKVKTNLKQRQIRQELSALSKVDHSQYDCCVVVILSHGTEV 237
Query: 237 RYSSDTD-IRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENED--FVQGGG 293
+S + DG+F+ + I Y N + P+ PK+F QAC G+ +D F
Sbjct: 238 SHSRFPGAVYGVDGQFVPVQHIATYLNGQYCPSLQGKPKLFFIQACGGDEKDTGFQVSPD 297
Query: 294 ALAPAPQVARDGA-----VXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDV 348
P P V D V P S+IL++ ST PG++S RD
Sbjct: 298 EFEP-PVVGADDQTDAIPVSSSSDSLSMSDEPDARASLPTSSDILVSYSTFPGYVSWRDP 356
Query: 349 KAGSWYIQVLCEVFAERA--HD 368
KAGSWY++ L V E A HD
Sbjct: 357 KAGSWYVETLDRVLEENAALHD 378
>UniRef50_Q9XYF4 Cluster: Caspase Nc precursor (EC 3.4.22.-)
(NEDD2-like caspase DRONC) [Contains: Caspase Nc subunit
1; Caspase Nc subunit 2]; n=2; Sophophora|Rep: Caspase
Nc precursor (EC 3.4.22.-) (NEDD2-like caspase DRONC)
[Contains: Caspase Nc subunit 1; Caspase Nc subunit 2] -
Drosophila melanogaster (Fruit fly)
Length = 450
Score = 150 bits (364), Expect = 6e-35
Identities = 121/447 (27%), Positives = 199/447 (44%), Gaps = 46/447 (10%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPR--------- 51
M + H++ I++N + LVE T+ + + M ++G+ + QM+ +D + P
Sbjct: 10 MPKRHREHIRKNLNILVEWTNYERLAMECVQQGILTVQMLRNTQDLNGKPFNMDEKDVRV 69
Query: 52 ERKRILYREITRRGPQAFTMLLEALREMGHWDL------VRDLDPNSP-LQLRARRP--- 101
E+ R L +IT+RGP A+ +L+ ALR + D V + D P + L RR
Sbjct: 70 EQHRRLLLKITQRGPTAYNLLINALRNINCLDAAVLLESVDESDSRPPFISLNERRTSRK 129
Query: 102 ----VLPPTRQGSDAXXXXXXXNSSEPVAIPCF------HVKKSTHFFEDDVSRDIQLYR 151
V P+ + S+ N P VKKS D S + Y+
Sbjct: 130 SADIVDTPSPEASEGPCVSKLRNEPLGALTPYVGVVDGPEVKKSKKIHGGD-SAILGTYK 188
Query: 152 TRSR-KRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQ--T 208
+SR RGVL++ + + + + R G D L +LF E+ F + Y N+ +Q
Sbjct: 189 MQSRFNRGVLLMVNIMDYP-DQNRRRIGAEKDSKSLIHLFQELNFTIFPYGNVNQDQFFK 247
Query: 209 RATLEQMSSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPN 268
T+ SS + EC +V+ +HG+ + DG + + I D+F K P
Sbjct: 248 LLTMVTSSSYVQNTECFVMVLMTHGNS--VEGKEKVEFCDGSVVDMQKIKDHFQTAKCPY 305
Query: 269 FTDLPKVFIFQACRGENEDF--VQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEK 326
+ PKV +F CRG+ D + G L A++
Sbjct: 306 LVNKPKVLMFPFCRGDEYDLGHPKNQGNLMEPVYTAQE----EKWPDTQTEGIPSPSTNV 361
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRL---R 383
P ++ L+ + PG+++HRD+ GSWYIQ C+V A+ AHD ++++ + + R
Sbjct: 362 PSLADTLVCYANTPGYVTHRDLDTGSWYIQKFCQVMADHAHDTDLEDILKKTSEAVGNKR 421
Query: 384 LRFG-RQTSSVDRWGFNNKLYLHPGLY 409
+ G QT + D GFN KLY +PG +
Sbjct: 422 TKKGSMQTGAYDNLGFNKKLYFNPGFF 448
>UniRef50_Q16PQ5 Cluster: Ecdysone-inducible caspase, putative; n=2;
Culicidae|Rep: Ecdysone-inducible caspase, putative -
Aedes aegypti (Yellowfever mosquito)
Length = 449
Score = 146 bits (355), Expect = 7e-34
Identities = 85/272 (31%), Positives = 136/272 (50%), Gaps = 21/272 (7%)
Query: 145 RDIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLT 204
R ++ Y R R RGV+ + + I+++ P R+G D L LF ++GF V Y++LT
Sbjct: 192 RILEAYEMRRRNRGVVFIVNVITYINETHPTRNGAEADKYNLVSLFQQLGFTVFYYEDLT 251
Query: 205 LEQTRATLEQMS-SVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNN 263
++ ++++ S EC + +HG+ + I +D + + ++ FNN
Sbjct: 252 SDEFNNLIKELKQSSYLSTECFVFYILAHGNHTK--GRDKIYLNDNSVLYVEDVLALFNN 309
Query: 264 RKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXX 323
P PK+F F CRG+N D+ G L A RDG +
Sbjct: 310 ANCPKLIRRPKLFFFSICRGDNPDY----GTLRLAEHTERDGMINLKKDPPT-------- 357
Query: 324 XEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDK--- 380
P Y+++LI ST+PG+ +HRD + GSW+++ +C+V+A+ AHD V++L LV K
Sbjct: 358 -NMPTYADMLICFSTVPGYAAHRDKQYGSWFVESMCKVWAQHAHDTDVEQLMKLVGKDSS 416
Query: 381 --RLRLRFGRQTSSVDRWGFNNKLYLHPGLYE 410
R QT ++ GF N LYL+PG YE
Sbjct: 417 TYRTEHHNALQTLGSEQRGFFNVLYLNPGYYE 448
Score = 36.7 bits (81), Expect = 1.1
Identities = 19/73 (26%), Positives = 35/73 (47%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M + + IQ N L++ T+ ++ + + S+ M D R + L+ +
Sbjct: 1 MDQRDRHQIQHNMDQLIQHTNYGVLMAECVGRQMMSEVMKAIIEDRYPDEASRHKKLFEK 60
Query: 61 ITRRGPQAFTMLL 73
IT+RGP AF +L+
Sbjct: 61 ITKRGPHAFDILV 73
>UniRef50_Q4V923 Cluster: Zgc:101776 protein; n=8;
Clupeocephala|Rep: Zgc:101776 protein - Danio rerio
(Zebrafish) (Brachydanio rerio)
Length = 436
Score = 140 bits (338), Expect = 8e-32
Identities = 111/403 (27%), Positives = 187/403 (46%), Gaps = 29/403 (7%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M+++H++ +QR+ +LV+ + + + L KGVF+Q MI+ + + T R++ R L ++
Sbjct: 1 MEQKHRQILQRHRLNLVKALNPEDVCDKLLSKGVFTQDMIDEIQSKA-TRRDQARQLVKD 59
Query: 61 ITRRGPQAFTMLLEALREMGHWDLVRDLDPNS----PLQLRARRPVLPPTRQGSDAXXXX 116
+ RG AF L++LRE GH DL L P + + +P Q +
Sbjct: 60 LETRGSLAFPAFLDSLRETGHNDLAELLQSGDGVHRPPVISVQPSPIPLPVQNLNHTEKP 119
Query: 117 XXXNSSEPVAIPC----FHVKKSTHFFEDDVSR-------DIQLYRTRSRKRGVLVVFSY 165
+ + P +P V K+ + V R IQ Y+ + GV ++ +
Sbjct: 120 DKPDIASPRLVPLRPESLPVHKTYSPPSETVVRPTRPRRDSIQCYKMDASPCGVCLIINN 179
Query: 166 ISFLLNIEPN-RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYE 223
I+F E N R G N+DCDKL+ F + FEV +NL ++ R + ++ + Y+
Sbjct: 180 INFEKASELNDRKGSNIDCDKLEKRFKGLNFEVTVKRNLKSKRIRHEMASLAKKDHSTYD 239
Query: 224 CVFLVVSSHGHERRYSSDTD-IRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACR 282
C +++ SHG E ++ + DG + + I +Y N + P+ PK+F QAC
Sbjct: 240 CCVVIILSHGTEASHNRFPGAVHGVDGPAVPIQIITNYLNGQNCPSLQGKPKLFFIQACG 299
Query: 283 GENED--FVQGGGALAPAPQVARD--GAVXXXXXXXXXXXXXXXXXEK---PLYSNILIA 335
G +D F + P D A+ + P S+IL++
Sbjct: 300 GGEKDIGFEVSPDDVQPCIGGIDDEMDAIPMSSSSDSLSTASDELDARASLPTPSDILVS 359
Query: 336 NSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLV 378
ST PG++S RD +AGSWY++ L V E A D+L T++
Sbjct: 360 YSTFPGYVSWRDTEAGSWYVENLDRVLEENA---ITDDLVTML 399
>UniRef50_UPI0000D57084 Cluster: PREDICTED: similar to CG8091-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG8091-PA - Tribolium castaneum
Length = 395
Score = 137 bits (332), Expect = 4e-31
Identities = 112/416 (26%), Positives = 190/416 (45%), Gaps = 41/416 (9%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M EH+ I ++F LV DL+ ++ +L K +M++ + + IL++
Sbjct: 1 MLPEHESLIYKHFPDLVRDCDLERIMRSLSFKDPIISKMMDNVKIEEDRRHNNRCILFQL 60
Query: 61 ITRRGPQAFTMLLEALREMGHWDLVRDLDPNSPLQLRARRPVLPPTRQGSDAXXXXXXXN 120
+ F L+E LR + + +L L+ P Q V + +
Sbjct: 61 VKTNSSTVFLKLVETLRTLNYHELADKLEDKPPTQRYKHTTVCNKPPE-----------S 109
Query: 121 SSEPVAIPCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVN 180
E + I VK +T F + D D Y+TRSR RG +++ + + F R G
Sbjct: 110 HLEKLKID---VKYATKFCDTD---DF-CYKTRSRNRGQVLIINNMVFETERHITRRGAE 162
Query: 181 VDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMS--SVLAGYECVFLVVSSHGHERRY 238
VD LK LF ++GF V Y+NL+ ++ + +++ S + F+++ SHG +
Sbjct: 163 VDERNLKELFEKMGFYVDLYRNLSRDEIKTVVKKFSEKEYKEAPDMAFVIIMSHG--EKI 220
Query: 239 SSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPA 298
+ T I SDG+ + I+ FNN+ F + PK+ IF CRG+ D + A
Sbjct: 221 ENKTVIIGSDGQAVEEEWIIMQFNNQSCSLFRNKPKILIFNICRGDLVD-----NLVHFA 275
Query: 299 PQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVL 358
Q D A ++ YS+++I + ++ GF +HRDV G WYI+++
Sbjct: 276 QQTQSDSAC---------TKNPEVGDDERYYSDLMICHPSVEGFQAHRDVVRGCWYIELI 326
Query: 359 CEVFAERAHDCHVDELFTLVDKRLRLRFG----RQTSSVDRWGFNNKLYLHPGLYE 410
C F E + + V+ + +V++ L+ R RQTS+ F YL+PG+YE
Sbjct: 327 CTTFMENSCEVDVETMMKMVERGLKKRISEKMTRQTSTFLNIAFKT-CYLNPGIYE 381
>UniRef50_Q90WU0 Cluster: Caspase 9; n=2; Gallus gallus|Rep: Caspase
9 - Gallus gallus (Chicken)
Length = 403
Score = 118 bits (285), Expect = 2e-25
Identities = 92/330 (27%), Positives = 146/330 (44%), Gaps = 13/330 (3%)
Query: 50 PRERKRILYREITRRGPQAFTMLLEALREMGHWDLVRDLD-----PNSP-LQLRARRPVL 103
P+E+ R L ++ RG QAF + L LR+ GH DL LD P SP + LR + L
Sbjct: 33 PKEQARQLVIDLETRGKQAFPIFLSILRDTGHGDLADMLDEGCGSPMSPPVDLRPVQLEL 92
Query: 104 PPTRQGSDAXXXXXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQLYRTRSRKR-GVLVV 162
P R+ +P + D SR + + G ++
Sbjct: 93 PGDRRDKSVSTAERLSIPVQPESERFRMPPAPAQGSAVDKSRPTDWCTSCEQTPCGHCLI 152
Query: 163 FSYISFLLNIE-PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LA 220
F+ +SF + + R G ++DC+KL+ F + F V T +NL ++ L +++ + +
Sbjct: 153 FNNVSFSRDSDLSTRAGSDIDCEKLEKRFRSLCFHVRTLRNLKAQEIDVELRKLARLDHS 212
Query: 221 GYECVFLVVSSHGHERRYSS-DTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQ 279
+C +V+ SHG + + I +DGK I + IV+YFN + P+ PK+F Q
Sbjct: 213 ALDCCLVVILSHGCQTSHIQFPGGIYGTDGKIIPIERIVNYFNGSQCPSLRGKPKLFFIQ 272
Query: 280 ACRGENEDFVQGGGALAPAPQVAR---DGAVXXXXXXXXXXXXXXXXXEKPLYSNILIAN 336
AC GE +D +P + R + P +IL++
Sbjct: 273 ACGGEQKDQGFEVDCESPQDETCRRSIESDAIPFQAPSGNEDEPDAVASLPTPGDILVSY 332
Query: 337 STLPGFISHRDVKAGSWYIQVLCEVFAERA 366
ST PGF+S RD +GSWY++ L V A
Sbjct: 333 STFPGFVSWRDKVSGSWYVETLDSVLEHYA 362
>UniRef50_UPI0000586459 Cluster: PREDICTED: similar to caspase-3,
partial; n=10; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to caspase-3, partial -
Strongylocentrotus purpuratus
Length = 437
Score = 111 bits (266), Expect = 4e-23
Identities = 98/418 (23%), Positives = 176/418 (42%), Gaps = 41/418 (9%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M++ ++ I+R L D + L + +F IE + T RE+ L E
Sbjct: 1 MEQADRETIKRKNVILSTDMDFVGVTSGLIARRIFENHHIEKFNSERST-REKNMALLME 59
Query: 61 ITRRGPQAFTMLLEALREMGHWDLVRDLDPNSPLQLRARRPVLPPTRQGSDAXXXXXXXN 120
I RGP+AFT L+E+L E DL + L ++ + + T +
Sbjct: 60 IETRGPKAFTSLVESLIESNQVDLAKLLGYSASGPSQGQMGQTQATTPHDNRPGPFGQPT 119
Query: 121 SSEPVAIPCFHVKKSTHFFEDDVSR-------DIQL-YRTRSRKRGVLVVFSYISFLLNI 172
P+ P + D S D +L Y+ +S+ RG+ ++ + +F
Sbjct: 120 QQVPLVWPARDSTGDYSSTQMDASGSYPQTMVDSELVYKMKSKPRGIALIINNKNF--KT 177
Query: 173 EPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQM-SSVLAGYECVFLVVSS 231
P R G ++DC L+ +F+++ F+V+ + +L + +EQ+ + ++C + +
Sbjct: 178 MPPRRGTDIDCRNLENIFTQLDFDVVVHNDLKKRDIQQKIEQVRKHNHSQFDCFIFAILT 237
Query: 232 HGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGEN-EDFVQ 290
HG E + +DG + + IV F + + P PK+F QACRG+ +D V+
Sbjct: 238 HGEE------GSVCGTDGCLVKIEDIVGPFCSDRCPTLNGKPKLFFLQACRGKKLDDGVE 291
Query: 291 G--GGALAPAPQVARDGAVXXXX--------------------XXXXXXXXXXXXXEKPL 328
G A+ P A D + P
Sbjct: 292 ATDGQAVPPTDGAASDAQANAQAKPQVDAQINDEELAKMMLKMELDSTDSFASSRSKVPS 351
Query: 329 YSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRF 386
S++L+A +T+PGF+S R+ + GSW+IQ L E + A + + + T+V+ ++ F
Sbjct: 352 QSDMLLAYATVPGFVSWRNAERGSWFIQALTETILQHAGEEDLLSMITMVNGKVARAF 409
>UniRef50_P42575 Cluster: Caspase-2 precursor (EC 3.4.22.55)
(CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural
precursor cell expressed developmentally down- regulated
protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18;
Caspase-2 subunit p13; Caspase-2 subunit p12]; n=34;
Euteleostomi|Rep: Caspase-2 precursor (EC 3.4.22.55)
(CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural
precursor cell expressed developmentally down- regulated
protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18;
Caspase-2 subunit p13; Caspase-2 subunit p12] - Homo
sapiens (Human)
Length = 452
Score = 106 bits (254), Expect = 1e-21
Identities = 109/409 (26%), Positives = 171/409 (41%), Gaps = 43/409 (10%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M H++ +++N L + L ++ L EK + + +M E + + + L
Sbjct: 32 MHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQ-AKVGSFSQNVELLNL 90
Query: 61 ITRRGPQAFTMLLEALRE--MGHWD----------------LVRDLDPNSPLQLRARRPV 102
+ +RGPQAF EALRE GH + L D D + P + P+
Sbjct: 91 LPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPL 150
Query: 103 LPPTRQGSDAXXXXXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQL-YRTRSRKRGVLV 161
R +D N PV C VK T F QL YR +SR RG+ +
Sbjct: 151 YKKLRLSTDTVEHSLD-NKDGPV---CLQVKPCTPEF---YQTHFQLAYRLQSRPRGLAL 203
Query: 162 VFSYISFLLNIEPN-RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLA 220
V S + F E R G +VD L LF +G++V + T ++ + L+ + + A
Sbjct: 204 VLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPA 263
Query: 221 GY--ECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIF 278
+ + + SHG E I DGK + L + F+N P+ + PK+F
Sbjct: 264 HRVTDSCIVALLSHGVEGA------IYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFI 317
Query: 279 QACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANST 338
QACRG+ D Q ++ A P S+++ +
Sbjct: 318 QACRGDETD-------RGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYAC 370
Query: 339 LPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFG 387
L G + R+ K GSWYI+ L +VF+ERA D HV ++ V+ ++ R G
Sbjct: 371 LKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREG 419
>UniRef50_P55211 Cluster: Caspase-9 precursor (EC 3.4.22.62)
(CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6)
(Apoptotic protease Mch-6) (Apoptotic protease-
activating factor 3) (APAF-3) [Contains: Caspase-9
subunit p35; Caspase-9 subunit p10]; n=23;
Tetrapoda|Rep: Caspase-9 precursor (EC 3.4.22.62)
(CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6)
(Apoptotic protease Mch-6) (Apoptotic protease-
activating factor 3) (APAF-3) [Contains: Caspase-9
subunit p35; Caspase-9 subunit p10] - Homo sapiens
(Human)
Length = 416
Score = 105 bits (252), Expect = 2e-21
Identities = 97/389 (24%), Positives = 162/389 (41%), Gaps = 13/389 (3%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPY-RDTSITPRERKRILYR 59
M E ++ ++R LVE +D + AL + +F MIE R S + R++ R L
Sbjct: 1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
Query: 60 EITRRGPQAFTMLLEALREMGHWDLVRDLDPNSPLQLRARRPVL----PPTRQGSDAXXX 115
++ RG QA + + L + G D++ + + +P L P +
Sbjct: 61 DLETRGSQALPLFISCLEDTGQ-DMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPE 119
Query: 116 XXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIE-P 174
+ PV I + D+ Y G ++ + ++F
Sbjct: 120 VLRPETPRPVDIGSGGFGDVGALESLRGNADLA-YILSMEPCGHCLIINNVNFCRESGLR 178
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQ-TRATLEQMSSVLAGYECVFLVVSSHG 233
R G N+DC+KL+ FS + F V +LT ++ A LE +C +V+ SHG
Sbjct: 179 TRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHG 238
Query: 234 HERRYSSDTD-IRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGG 292
+ + + +DG +S+ IV+ FN P+ PK+F QAC GE +D
Sbjct: 239 CQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEV 298
Query: 293 GALAP---APQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVK 349
+ +P +P + P S+I ++ ST PGF+S RD K
Sbjct: 299 ASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPK 358
Query: 350 AGSWYIQVLCEVFAERAHDCHVDELFTLV 378
+GSWY++ L ++F + AH + L V
Sbjct: 359 SGSWYVETLDDIFEQWAHSEDLQSLLLRV 387
>UniRef50_P42573 Cluster: Cell death protein 3 precursor (EC
3.4.22.-) [Contains: Cell death protein 3 subunit 1;
Cell death protein 3 subunit 2]; n=3;
Caenorhabditis|Rep: Cell death protein 3 precursor (EC
3.4.22.-) [Contains: Cell death protein 3 subunit 1;
Cell death protein 3 subunit 2] - Caenorhabditis elegans
Length = 503
Score = 99.1 bits (236), Expect = 2e-19
Identities = 79/250 (31%), Positives = 110/250 (44%), Gaps = 18/250 (7%)
Query: 149 LYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQT 208
+YR S RG+ ++ + F P R+G D D L LF +G+ V+ NLT
Sbjct: 234 MYRNFSSPRGMCLIINNEHF--EQMPTRNGTKADKDNLTNLFRCMGYTVICKDNLTGRGM 291
Query: 209 RATLEQMSSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPN 268
T+ + + + LV+ SHG E DI IS + I D N P
Sbjct: 292 LLTIRDFAKHESHGDSAILVILSHGEENVIIGVDDIP------ISTHEIYDLLNAANAPR 345
Query: 269 FTDLPKVFIFQACRGENED-------FVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXX 321
+ PK+ QACRGE D V G A RDG +
Sbjct: 346 LANKPKIVFVQACRGERRDNGFPVLDSVDGVPAFLRRGWDNRDGPLFNFLGCVRPQVQQV 405
Query: 322 XXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKR 381
+KP ++ILIA +T ++S R+ GSW+IQ +CEVF+ A D V EL T V+K+
Sbjct: 406 WR-KKPSQADILIAYATTAQYVSWRNSARGSWFIQAVCEVFSTHAKDMDVVELLTEVNKK 464
Query: 382 LRLRFGRQTS 391
+ F QTS
Sbjct: 465 VACGF--QTS 472
Score = 43.2 bits (97), Expect = 0.013
Identities = 24/90 (26%), Positives = 42/90 (46%), Gaps = 1/90 (1%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M+++ + ++RN +D ++ L K V + + T RE++R + +
Sbjct: 2 MRQDRRSLLERNIMMFSSHLKVDEILEVLIAKQVLNSDNGDMINSCG-TVREKRREIVKA 60
Query: 61 ITRRGPQAFTMLLEALREMGHWDLVRDLDP 90
+ RRG AF +ALR GH L L+P
Sbjct: 61 VQRRGDVAFDAFYDALRSTGHEGLAEVLEP 90
>UniRef50_P55212 Cluster: Caspase-6 precursor (EC 3.4.22.59)
(CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6
subunit p18; Caspase-6 subunit p11]; n=35;
Euteleostomi|Rep: Caspase-6 precursor (EC 3.4.22.59)
(CASP-6) (Apoptotic protease Mch-2) [Contains: Caspase-6
subunit p18; Caspase-6 subunit p11] - Homo sapiens
(Human)
Length = 293
Score = 99.1 bits (236), Expect = 2e-19
Identities = 69/250 (27%), Positives = 109/250 (43%), Gaps = 17/250 (6%)
Query: 138 FFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIE-PNRDGVNVDCDKLKYLFSEIGFE 196
F++ ++ + Y+ R+RG+ ++F++ F ++ P R G D D L FS++GFE
Sbjct: 25 FYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFE 84
Query: 197 VLTYQNLTLEQTRATLEQMSSVL-AGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLY 255
V + +L E+ + ++S+V A +C V SHG I D K I +
Sbjct: 85 VKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHG------EGNHIYAYDAK-IEIQ 137
Query: 256 AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXX 315
+ F K + PK+FI QACRG D + P V
Sbjct: 138 TLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDV-----PVIPLDVVDNQ---TEKLDTNI 189
Query: 316 XXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELF 375
P ++ L+ S G+ SHR+ GSWYIQ LCE+ + EL
Sbjct: 190 TEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELL 249
Query: 376 TLVDKRLRLR 385
TLV++++ R
Sbjct: 250 TLVNRKVSQR 259
>UniRef50_O01382 Cluster: Caspase precursor (EC 3.4.22.-) (drICE)
[Contains: Caspase subunit p21; Caspase subunit p12];
n=13; Endopterygota|Rep: Caspase precursor (EC 3.4.22.-)
(drICE) [Contains: Caspase subunit p21; Caspase subunit
p12] - Drosophila melanogaster (Fruit fly)
Length = 339
Score = 97.9 bits (233), Expect = 4e-19
Identities = 66/239 (27%), Positives = 109/239 (45%), Gaps = 27/239 (11%)
Query: 150 YRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTR 209
Y R + RG+ ++F++ F + +R G NVDC+ L + ++ FEV Y++ +
Sbjct: 86 YNMRHKNRGMALIFNHEHFEVPTLKSRAGTNVDCENLTRVLKQLDFEVTVYKDCRYKDIL 145
Query: 210 ATLEQMSSV-LAGYECVFLVVSSHGHERR-YSSDTDIRCSDGKFISLYAIVDYFNNRKLP 267
T+E +S + +C+ + + SHG Y+ DT + + I +F P
Sbjct: 146 RTIEYAASQNHSDSDCILVAILSHGEMGYIYAKDTQYKLDN--------IWSFFTANHCP 197
Query: 268 NFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKP 327
+ PK+F QAC+G+ D GG Q DG + P
Sbjct: 198 SLAGKPKLFFIQACQGDRLD----GGVTMQRSQTETDG-------------DSSMSYKIP 240
Query: 328 LYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRF 386
++++ LIA ST+PGF S R+ GSW++Q LC A + L T V +R+ + F
Sbjct: 241 VHADFLIAYSTVPGFYSWRNTTRGSWFMQSLCAELAANGKRLDILTLLTFVCQRVAVDF 299
>UniRef50_UPI0000E47F37 Cluster: PREDICTED: similar to caspase-3,
partial; n=3; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to caspase-3, partial -
Strongylocentrotus purpuratus
Length = 608
Score = 95.5 bits (227), Expect = 2e-18
Identities = 74/243 (30%), Positives = 109/243 (44%), Gaps = 28/243 (11%)
Query: 155 RKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQ 214
R +G++ V + F + R G +VD +K++F+EIG+ QNLT E R L+
Sbjct: 4 RNKGLVFVLNNYLFGPDRTRERKGSDVDLANVKHVFTEIGYTADEAQNLTAEGIRQKLKS 63
Query: 215 MSS-VLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLP 273
++ +L+ + V LV SHG E I+ +D + +++ I D F+ P P
Sbjct: 64 LTQKILSSHTSVVLVFMSHGKE------AGIQGTDEEVVTVKEIKDMFSGNNCPALIGKP 117
Query: 274 KVFIFQACRGEN------------------EDFV--QGGGALAPAPQVARDGAVXXXXXX 313
K+ IFQACRGE DFV GG A V +D A
Sbjct: 118 KIMIFQACRGEKITPSAPSISSSGVDNGICTDFVGTDGGAGDGGATMVTKDEACLTSPGR 177
Query: 314 XXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDE 373
+++ IA ST G+ S R + GSW+IQ LCE AHD H+D+
Sbjct: 178 VGGGEVEFDCSVAD-NADMYIAQSTSEGYFSLRHRQNGSWFIQALCEELIASAHDHHLDD 236
Query: 374 LFT 376
+ T
Sbjct: 237 IMT 239
>UniRef50_UPI0000E49D20 Cluster: PREDICTED: hypothetical protein;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
hypothetical protein - Strongylocentrotus purpuratus
Length = 329
Score = 95.1 bits (226), Expect = 3e-18
Identities = 67/247 (27%), Positives = 108/247 (43%), Gaps = 18/247 (7%)
Query: 141 DDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIEPN-RDGVNVDCDKLKYLFSEIGFEVLT 199
+D +R + Y + RG+ V+F++ +F N R G N D + LK +GF+VL
Sbjct: 66 EDTTR-LLYYDMNHKNRGMAVIFNHENFDWKTGMNQRVGTNHDVENLKLHLGRLGFKVLV 124
Query: 200 YQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIV 258
+Q+ + + R LE S +C V +HG D I + + L +
Sbjct: 125 FQDASASELRRNLELASKADHTDSDCFMCVFLTHG-------DDGILYARDSTLDLQELF 177
Query: 259 DYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXX 318
++F K P PK+F+ QACRG+ + + P V A
Sbjct: 178 EFFRGEKCPTLIGKPKLFLIQACRGDRHEI-----GVDPPVDVTDSAAPEDEWVTVTDSG 232
Query: 319 XXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLV 378
P +++L++ S + G+ SHRD GSWYIQ L +V A + E+ TLV
Sbjct: 233 TRPTI---PAAADMLLSYSVVQGYYSHRDTAFGSWYIQALAKVLALHGTTMEITEILTLV 289
Query: 379 DKRLRLR 385
++ + R
Sbjct: 290 NQLISQR 296
>UniRef50_UPI00015B57EE Cluster: PREDICTED: similar to
ENSANGP00000010319; n=2; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000010319 - Nasonia
vitripennis
Length = 379
Score = 91.1 bits (216), Expect = 5e-17
Identities = 63/243 (25%), Positives = 107/243 (44%), Gaps = 25/243 (10%)
Query: 145 RDIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLT 204
+D Y R RG V+F++ +F E R+G +VD +++ F ++GF V +
Sbjct: 128 KDADRYNMEHRNRGKCVIFNHETFDTGFE-TREGSSVDARRIEQTFQQLGFTVEICDDYE 186
Query: 205 LEQTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNN 263
L ++S + +C+ + V +HG + D+ C+ L + F
Sbjct: 187 HSGVMNKLNELSEEDHSDNDCLCIFVLTHGLKN------DLICAKDVVYKLENVWKPFTA 240
Query: 264 RKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXX 323
K + PK+F FQACRG+N DG +
Sbjct: 241 DKCSSLAGKPKLFFFQACRGDN-----------------LDGGIKMMRSGTTETDSSSAS 283
Query: 324 XEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLR 383
+ P Y++ L A+ST+ GF S R+ + G+WY+Q LC+VF E A + +L T+ +++
Sbjct: 284 YQIPTYADFLFAHSTVQGFYSWRNPEEGTWYVQSLCDVFDEYAATHDLAKLMTITARKVA 343
Query: 384 LRF 386
F
Sbjct: 344 TNF 346
>UniRef50_Q6E5N8 Cluster: Caspase 8; n=1; Ictalurus punctatus|Rep:
Caspase 8 - Ictalurus punctatus (Channel catfish)
Length = 366
Score = 90.2 bits (214), Expect = 8e-17
Identities = 65/215 (30%), Positives = 97/215 (45%), Gaps = 11/215 (5%)
Query: 146 DIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTL 205
+I Y+ S RG V+ + ++F ++ R G +D D LK +F +GF V ++N T
Sbjct: 107 EITEYKMSSEPRGFCVIINNVNFASPLK-ERYGSKLDEDSLKEVFQWLGFNVCVHKNQTA 165
Query: 206 EQTRATLEQMSSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRK 265
EQ + L++ S +C + SHG SSD + +DG S I F+
Sbjct: 166 EQMKDLLKKYSQQHHDGDCFVCCIMSHG-----SSD-GVHGTDGAIASRDDIFGPFSGNS 219
Query: 266 LPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXE 325
P+ + PKVFI QACRG+ + P D
Sbjct: 220 CPSLINKPKVFIIQACRGKEYHLPV---EVQPDSYEEED-TEAETEDEKSLETDAVQMMT 275
Query: 326 KPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCE 360
P ++ LIA ST+ G+ S RD +GSW+IQ LC+
Sbjct: 276 IPADADFLIARSTVKGYYSMRDTISGSWFIQSLCQ 310
>UniRef50_Q8I6Y2 Cluster: Caspase-3; n=2; Geodia cydonium|Rep:
Caspase-3 - Geodia cydonium (Sponge)
Length = 426
Score = 86.6 bits (205), Expect = 1e-15
Identities = 86/371 (23%), Positives = 149/371 (40%), Gaps = 30/371 (8%)
Query: 57 LYREITRRGPQAFTMLLEALREM--GHWDLVRDLDPNSPLQLRARRPVLPPTRQGSDAXX 114
L + + RR +L+E L E + DL++ + P + R P PPT +
Sbjct: 59 LMKALRRRDSSVLDILVECLAEQQEANADLIKKIRSFFPE--KPRPPPPPPTIDSTPVTR 116
Query: 115 XXXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIEP 174
P A + D +D Y+ SR RG+ ++ + +F ++
Sbjct: 117 YDDWPAPIAPTATSHPPIPPPPEEGTDAGRKDA--YKMSSRPRGMALIINNRNFTCGMK- 173
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHG 233
R G + D + L LF+ +G + NLT + E ++ + Y+CV + + +HG
Sbjct: 174 ERVGTDKDAENLYGLFNWLGMATIRKDNLTGKAMTREFEDLARRDHSAYDCVVVAILTHG 233
Query: 234 HERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDF-VQGG 292
R S +DG I + + YF+ P+ PKVF+ QACRG D+ V+
Sbjct: 234 ISGRLYS------TDGDLIPVEDLTKYFDGVNRPSLIGKPKVFVVQACRGGKFDYGVESE 287
Query: 293 GALAPAPQVAR-----------DGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPG 341
V + D V P ++ ++A +T+PG
Sbjct: 288 STDGEGESVNKETANEMMEKQFDKVVEKALDADETDGGGYSREALPTEADFVLAYATVPG 347
Query: 342 FISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRF---GRQTS-SVDRWG 397
++S R+ + GSW+I+ + + A H ++ T V++++ F GR
Sbjct: 348 YVSWRNSEYGSWFIKAFVDTMRDLASKEHFMDILTEVNRKVAYDFQSRGRNKQIPAPVTM 407
Query: 398 FNNKLYLHPGL 408
KLY PG+
Sbjct: 408 LTRKLYFRPGV 418
>UniRef50_Q7Q1E0 Cluster: ENSANGP00000015118; n=2; Culicidae|Rep:
ENSANGP00000015118 - Anopheles gambiae str. PEST
Length = 294
Score = 86.2 bits (204), Expect = 1e-15
Identities = 61/243 (25%), Positives = 111/243 (45%), Gaps = 33/243 (13%)
Query: 143 VSRDIQLYRTRSRKRGVLVVFSYISF-LLNIE-PNRDGVNVDCDKLKYLFSEIGFEVLTY 200
+ R Y ++RG+ ++FS+ + + N+ P R+G +DC +LK F+V Y
Sbjct: 47 IERYAAYYPMNHKRRGMALIFSHNKYNVRNVSLPVREGSAIDCKRLKETLELFRFDVKVY 106
Query: 201 QNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVD 259
+ LE+ ++ + ++SS+ + +C + + +HG D I + + L I
Sbjct: 107 PDFKLEEIKSVIGKVSSMDHSDSDCFLVAILTHG------EDGGIVYAYDQPYELSLIWS 160
Query: 260 YFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXX 319
+F P+ PK+F+ QACRG D +V +DG
Sbjct: 161 FFTADNCPSLAGRPKIFVVQACRGNQLDH---------GVKVQKDGVARYSI-------- 203
Query: 320 XXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVD 379
P +++ L A +T+PGF++ R+ GSW+I LC+ E H ++ L T V
Sbjct: 204 -------PTHADFLFAYATIPGFMAFRNTTEGSWFINELCKELQENGHRYDINTLLTFVT 256
Query: 380 KRL 382
+++
Sbjct: 257 QKV 259
>UniRef50_UPI0000E45DDA Cluster: PREDICTED: similar to caspase 3;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
similar to caspase 3 - Strongylocentrotus purpuratus
Length = 526
Score = 85.8 bits (203), Expect = 2e-15
Identities = 67/243 (27%), Positives = 116/243 (47%), Gaps = 19/243 (7%)
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV--LAG---YECVFLVV 229
+R G VD + ++++F +IG+E + +NL+ + R+ L++ S L G + V LV+
Sbjct: 238 DRPGSEVDLENIEHVFRQIGYEPVIMKNLSANEIRSFLDKSVSRINLEGSIRHSSVVLVL 297
Query: 230 SSHGHERR-YSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGE--NE 286
SHG +R Y +D ++ +++ I F+ R+ P PK+F QACRG+ +
Sbjct: 298 MSHGEKRGIYGTDLEV-------VTIQEIKSKFSGRQCPALLGKPKIFFIQACRGQMRTK 350
Query: 287 DFVQGGGALAPAP-QVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISH 345
+ +P ++ D + + P ++I +A +T G+ S
Sbjct: 351 SALDTDDPRRLSPIEMVDDPDIDSCSSRRPTDDAVDIDGDVPDNADIYVAYATSEGYFSI 410
Query: 346 RDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGRQTSSVDRWGFNNKLYLH 405
R+ GSW+IQ LCE AH H+D+L T++++ R G S VD G K
Sbjct: 411 RNQVKGSWFIQSLCEELI--AH-VHIDDLDTIMNRVTRRVIGFTRSVVDGDGKKKKWLQT 467
Query: 406 PGL 408
P +
Sbjct: 468 PDI 470
>UniRef50_Q0Z8U7 Cluster: Caspase-8; n=1; Haemaphysalis
longicornis|Rep: Caspase-8 - Haemaphysalis longicornis
(Bush tick)
Length = 306
Score = 85.8 bits (203), Expect = 2e-15
Identities = 65/267 (24%), Positives = 117/267 (43%), Gaps = 21/267 (7%)
Query: 149 LYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQT 208
+Y + RG+ ++ + + F N P R G VD +++ LF + F V T+++L+ +
Sbjct: 48 VYPMTQKPRGLCIIINNVDFG-NRFPKRHGSEVDVRRMEDLFEALFFRVQTHRDLSADDM 106
Query: 209 RATLEQMSSV--LAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISL-YAIVDYFNNRK 265
++ L + EC+ +++ SHG + I +DGK+++L + FN+
Sbjct: 107 KSVLSDAAKEDKQKNAECLVVILMSHGE------NDGIYGTDGKWLNLKQEVYTQFNDSN 160
Query: 266 LPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXE 325
P+ PK+F QACRG +DF G AP R
Sbjct: 161 CPSLQGKPKLFFVQACRGREDDFRTDGMRGAPNSSHKRKDWPTLEQDRQSMDWIAD---- 216
Query: 326 KPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLR 385
S + IA +T P ++HRD GSW++ + ++F A + ++ L V + ++
Sbjct: 217 ---VSEMHIAEATRPELVAHRDTAFGSWFLSAVYKIFTCHAWELPLERLMERVQEEVQEN 273
Query: 386 FG----RQTSSVDRWGFNNKLYLHPGL 408
+Q + +LY +PGL
Sbjct: 274 TSDSNIKQFPLFTKLRATKELYFNPGL 300
>UniRef50_Q7Q803 Cluster: ENSANGP00000021367; n=6; Anopheles gambiae
str. PEST|Rep: ENSANGP00000021367 - Anopheles gambiae
str. PEST
Length = 320
Score = 85.4 bits (202), Expect = 2e-15
Identities = 61/241 (25%), Positives = 106/241 (43%), Gaps = 13/241 (5%)
Query: 150 YRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTR 209
Y +RGV VF++ FL E R G + DCD ++ + + FEV Y +LT ++ +
Sbjct: 57 YNMSHNRRGVAAVFNHRKFLHASE--RKGTDADCDNIRQVLIYLQFEVRVYDDLTRKEIK 114
Query: 210 ATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPN 268
L+ ++ +C+ +V+ +HG D + DG F ++ + + F P+
Sbjct: 115 QVLDDLAEEDHKNSDCLLVVIMTHG------DDDVLHAKDGTF-NVDRLWENFIGDSCPS 167
Query: 269 FTDLPKVFIFQACRGENEDF-VQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEK- 326
PK+F QACRG + D V + + A+ +
Sbjct: 168 LLGKPKLFFIQACRGSSFDTGVHFSQCMTQVAKTVVPYAMRELPQPSIVPGCPKSSIQYA 227
Query: 327 -PLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLR 385
P +++L+ ST G S R+ GSW+I+ LC+ E + + +L T V +R+
Sbjct: 228 IPSMADLLVMYSTYKGHYSWRNPSTGSWFIRALCDELREHGNSKELLQLLTSVSRRVAYE 287
Query: 386 F 386
F
Sbjct: 288 F 288
>UniRef50_Q504J1 Cluster: Caspase b; n=7; Danio rerio|Rep: Caspase b
- Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 404
Score = 85.0 bits (201), Expect = 3e-15
Identities = 78/289 (26%), Positives = 127/289 (43%), Gaps = 36/289 (12%)
Query: 127 IPCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKL 186
IPC K+T DI R+ ++++G+ ++ + I F N + NR+G + D +
Sbjct: 145 IPCSQETKNTLLKAH--GDDIYTPRSGTQRKGLALLITNIQFA-NTQHNRNGADRDEENA 201
Query: 187 KYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSSHGHERRYSSDTDI 244
++L +GF V+ Y+NL+ + R +E S + F+V+ SHG R + D +
Sbjct: 202 EWLLRSLGFAVIKYRNLSGKDIRRAVENFSKRREHEDADSTFIVIMSHG-TRIDNKDAIV 260
Query: 245 RCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARD 304
SD + + + N+ P D PKV + QACRG Q G LA A D
Sbjct: 261 GVSDDVYF-IEETFSHLNSVNCPALIDKPKVILIQACRGG-----QSSGVLAQDSVFASD 314
Query: 305 GAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAE 364
V + + + ST+P ++R+ GS++I + +VF
Sbjct: 315 SWVH-------------------MEKDFVCFMSTMPNTFAYRNPIEGSFFISYIVDVFCS 355
Query: 365 RAHDCHVDELFTLVDKRLR--LRFGRQTS---SVDRWGFNNKLYLHPGL 408
AH + ELF V R+ RF Q ++R + + YL PGL
Sbjct: 356 SAHRDDIMELFRKVTLRMEKDQRFQGQAKLLPCIERTSISKRFYLFPGL 404
>UniRef50_UPI00015B4D75 Cluster: PREDICTED: similar to CG7788-PA;
n=1; Nasonia vitripennis|Rep: PREDICTED: similar to
CG7788-PA - Nasonia vitripennis
Length = 456
Score = 83.4 bits (197), Expect = 1e-14
Identities = 69/256 (26%), Positives = 115/256 (44%), Gaps = 27/256 (10%)
Query: 147 IQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLE 206
I Y KRG+ ++F++ F + +R G NVDC+ L GFEV + +LT +
Sbjct: 208 ISRYENSCSKRGLALIFNHEFFEDDAINSRTGTNVDCENLASTLKSFGFEVRHFHDLTYQ 267
Query: 207 QTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRK 265
L +++ + + ++C+ +VV SHG ++ D K+ + +I F +
Sbjct: 268 CISNYLGEVAKMDHSQHDCLVVVVLSHG------DLGELYAHDRKY-NAESIWSSFTSSN 320
Query: 266 LPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXE 325
P+ P++F QACRG+ D G + DG
Sbjct: 321 CPSLEGKPRLFFIQACRGDQTD----EGIKLQYCRSEPDG-------------HPNLVFR 363
Query: 326 KPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLR 385
P + + LIA ST+PGF S R+ K GSW++Q LC + + T V +R+ +
Sbjct: 364 IPTHRDFLIAYSTIPGFYSWRNKKQGSWFVQALCSELDVYGDRQDLLTILTFVCQRVAID 423
Query: 386 FGRQTSSVDRWGFNNK 401
F ++ S +R F+ K
Sbjct: 424 F--ESYSPERANFHQK 437
>UniRef50_A2BGE2 Cluster: Novel protein similar to caspase 8; n=4;
Danio rerio|Rep: Novel protein similar to caspase 8 -
Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 366
Score = 83.4 bits (197), Expect = 1e-14
Identities = 69/230 (30%), Positives = 102/230 (44%), Gaps = 25/230 (10%)
Query: 142 DVSRDIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQ 201
D + + Y +S RG+ ++F+ +F + + R G +D LK LF +GF V Q
Sbjct: 115 DKTNTMNEYEMKSNPRGLCLIFNNENFK-DPDMKRHGSQMDTASLKDLFEWLGFSVEIKQ 173
Query: 202 NLTLEQTRATLEQMSSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYF 261
+ T+ + TL++ S +C V SHG+E + + SD K + I F
Sbjct: 174 DQTVSAMKRTLKEYSEDRKHGDCFVCCVLSHGNE------SGVLGSDEKICPVDDITSPF 227
Query: 262 NNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXX 321
N + PKVF QACRG +Q +A DG+
Sbjct: 228 NGANCSSLAGKPKVFFIQACRGHE---IQSKVMVA-------DGS-----GGSRTQKPGR 272
Query: 322 XXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAE---RAHD 368
P S+ LIA ST+ G++S RD +G+W+IQ LCE E R HD
Sbjct: 273 VSVSIPKDSDFLIARSTVEGYVSIRDRTSGTWFIQSLCENLKEGSKRGHD 322
>UniRef50_P31944 Cluster: Caspase-14 precursor (EC 3.4.22.-)
(CASP-14) [Contains: Caspase-14 subunit 1; Caspase-14
subunit 2]; n=14; Mammalia|Rep: Caspase-14 precursor (EC
3.4.22.-) (CASP-14) [Contains: Caspase-14 subunit 1;
Caspase-14 subunit 2] - Homo sapiens (Human)
Length = 242
Score = 83.0 bits (196), Expect = 1e-14
Identities = 63/221 (28%), Positives = 101/221 (45%), Gaps = 30/221 (13%)
Query: 166 ISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLAGYE-- 223
++ +L + R+G D D L+++F ++ FE ++ T EQ + LE+ + E
Sbjct: 19 LALILCVTKAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDP 78
Query: 224 --CVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQAC 281
C F+V+ +HG E + DG+ + L + + NN+ PKV+I QAC
Sbjct: 79 VSCAFVVLMAHGREGFLKGE------DGEMVKLENLFEALNNKNCQALRAKPKVYIIQAC 132
Query: 282 RGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPG 341
RGE D P V D V P Y++ L ST+ G
Sbjct: 133 RGEQRD---------PGETVGGDEIVMVIKDSPQTI---------PTYTDALHVYSTVEG 174
Query: 342 FISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRL 382
+I++R + GS +IQ L +VF +R H+ EL T V +R+
Sbjct: 175 YIAYRHDQKGSCFIQTLVDVFTKRKG--HILELLTEVTRRM 213
>UniRef50_Q5C0Y4 Cluster: SJCHGC07329 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC07329 protein - Schistosoma
japonicum (Blood fluke)
Length = 239
Score = 81.0 bits (191), Expect = 5e-14
Identities = 62/212 (29%), Positives = 95/212 (44%), Gaps = 21/212 (9%)
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLA--GYECVFLVVSSH 232
+R G + D KL+ LF + + V +N+ E + + + L++ +H
Sbjct: 15 SRLGSSHDVTKLQLLFEDFMYSVAVIRNVNGENLIKVVREFARKPEHNNVHAAVLIILAH 74
Query: 233 GHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGE--NEDFVQ 290
G E I SDG +S+ +V F N++ P PK + QACRGE N + +
Sbjct: 75 GLEHH------IIASDGIHVSIDELVSCFTNKRCPLLAGKPKFILIQACRGEERNHNDSK 128
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
G L P +R+ ++ P S+ +IA +TLPGF+S R
Sbjct: 129 MGDFLDSLPSNSREISLDPSSWLSL-----------PHMSDCVIAYTTLPGFVSWRSETE 177
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLVDKRL 382
GSWY++V EV H H+ EL T V+ RL
Sbjct: 178 GSWYVKVFVEVTRMHGHRLHMLELLTEVNNRL 209
>UniRef50_Q3HL92 Cluster: Caspase-like protein; n=6; Eumetazoa|Rep:
Caspase-like protein - Aiptasia pallida (Sea anemone)
Length = 415
Score = 80.6 bits (190), Expect = 7e-14
Identities = 103/407 (25%), Positives = 175/407 (42%), Gaps = 64/407 (15%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M++ H+ A++ N +L+ + + LY G+ + + + S T ER + L
Sbjct: 1 MEQIHRDALRSNRVALIRDLEASKVASNLYGAGILDENDKDTVQAKS-TREERAQTLLDM 59
Query: 61 ITRRGPQAFTMLLEALREMGHWDLVRDLDPNS-PLQ--------LRARRPVLPPTRQGSD 111
+ R+GP+AF +AL ++ L R L+P+S P Q +R R + P S
Sbjct: 60 LPRKGPKAFNAFCDALIDISP-HLERLLNPSSQPTQGAPTSESDVRVTRAAVHPRSVEST 118
Query: 112 -----------AXXXXXXXNSSE--PVAIPCFHVKKSTHFFEDDVSRDIQLYRTRSRKRG 158
A NS E P ST + +Y+ RG
Sbjct: 119 FSDQTAEKTPIASTDGASENSGEDNPDGGLSIFGSGSTRTRTSEPIDTRSMYKMDKTPRG 178
Query: 159 VLVVFSYISFL----LNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQ 214
V V+ + SFL ++ P R+G +VD D L +F ++GF L Y + ++ + + +
Sbjct: 179 VAVIINNKSFLPASGMHRYP-RNGTDVDRDALDKVFQKLGFNTLVYNDQSVYEIQKIFKS 237
Query: 215 MSSVLAGYECVFLV-VSSHGHER-RYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDL 272
+++ E +V + +HG E Y++D I+ D ++ +F K N
Sbjct: 238 LAARDYSKENALIVSILTHGEEGILYATDGTIQIRD--------MMRWF---KGTNLVGK 286
Query: 273 PKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNI 332
PK+FIFQAC+G +++ G A P R + P+ ++
Sbjct: 287 PKIFIFQACQG--HEYMDGVDATDAPPADKR--------------------VQIPVEADF 324
Query: 333 LIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVD 379
L A ST+PG+ S R+ GSW+IQ + EVF + A + + T V+
Sbjct: 325 LYAYSTVPGYYSWRNSVNGSWFIQSIAEVFDKYAKTTDLLTMMTRVN 371
>UniRef50_UPI0000519DFF Cluster: PREDICTED: similar to Caspase
precursor (drICE); n=1; Apis mellifera|Rep: PREDICTED:
similar to Caspase precursor (drICE) - Apis mellifera
Length = 280
Score = 80.2 bits (189), Expect = 9e-14
Identities = 66/253 (26%), Positives = 106/253 (41%), Gaps = 30/253 (11%)
Query: 145 RDIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLT 204
+D +Y +KRG V+F++ F N E R+G N D + FS +GFEV Y++L
Sbjct: 31 KDSPIYSMTQKKRGKCVIFNHEKFENNRESQRNGTNYDEKAINETFSTLGFEVKIYKDLK 90
Query: 205 LEQTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNN 263
+ + + + +C+ + +HG S DI + I FN+
Sbjct: 91 FNKIIEVITSLQNENHDDCDCICFFILTHGKIGDNVSAYDIS------YPVQMIWQPFNS 144
Query: 264 RKLPNFTDLPKVFIFQACRGENEDF-VQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXX 322
+ PK+F QACRG D +QG R G
Sbjct: 145 DNCISLAGKPKLFFIQACRGVTSDSGIQG-----------RSG-----------IDSDEM 182
Query: 323 XXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRL 382
P+ ++ L A ST+ G S RD GSWYIQ LC+V E + + ++ T+ +++
Sbjct: 183 TYVLPMTADFLYAYSTMEGCYSFRDTNKGSWYIQTLCKVINEHWKNYDMLKMLTITLRKV 242
Query: 383 RLRFGRQTSSVDR 395
+ Q +D+
Sbjct: 243 ATEYSSQHDEMDK 255
>UniRef50_Q4FJK5 Cluster: Casp9 protein; n=20; Eutheria|Rep: Casp9
protein - Mus musculus (Mouse)
Length = 454
Score = 80.2 bits (189), Expect = 9e-14
Identities = 59/208 (28%), Positives = 91/208 (43%), Gaps = 5/208 (2%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQ-TRATLEQMSSVLAGYECVFLVVSSHGH 234
R G N+D DKL++ F + F V +LT ++ A +E +C +V+ SHG
Sbjct: 218 RTGSNLDRDKLEHRFRWLRFMVEVKNDLTAKKMVTALMEMAHRNHRALDCFVVVILSHGC 277
Query: 235 ERRYSSDTD-IRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDF---VQ 290
+ + + +DG +S+ IV+ FN P+ PK+F QAC GE +D V
Sbjct: 278 QASHLQFPGAVYGTDGCSVSIEKIVNIFNGSGCPSLGGKPKLFFIQACGGEQKDHGFEVA 337
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
+ + P S+IL++ ST PGF+S RD K+
Sbjct: 338 CTSSQGRTLDSDSEPDAVPYQEGPRPLDQLDAVSSLPTPSDILVSYSTFPGFVSWRDKKS 397
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLV 378
GSWYI+ L + + A + L V
Sbjct: 398 GSWYIETLDGILEQWARSEDLQSLLLRV 425
>UniRef50_UPI0000ECB87F Cluster: Caspase-10 precursor (EC 3.4.22.63)
(CASP-10) (ICE-like apoptotic protease 4) (Apoptotic
protease Mch-4) (FAS-associated death domain protein
interleukin-1B-converting enzyme 2) (FLICE2) [Contains:
Caspase-10 subunit p23/17; Caspase-10 subunit p12].;
n=2; Gallus gallus|Rep: Caspase-10 precursor (EC
3.4.22.63) (CASP-10) (ICE-like apoptotic protease 4)
(Apoptotic protease Mch-4) (FAS-associated death domain
protein interleukin-1B-converting enzyme 2) (FLICE2)
[Contains: Caspase-10 subunit p23/17; Caspase-10 subunit
p12]. - Gallus gallus
Length = 537
Score = 79.4 bits (187), Expect = 2e-13
Identities = 58/215 (26%), Positives = 98/215 (45%), Gaps = 21/215 (9%)
Query: 147 IQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLE 206
+ Y+ +RG+ +V + + F + R G D +L+ +F+ +G +V TY + T +
Sbjct: 282 VSSYKMDGPRRGICLVINNVKFD-GVLQERKGSYKDACELERVFTWLGLDVRTYTDQTSD 340
Query: 207 QTRATLE--QMSSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNR 264
Q + ++ Q S +C + SHG + DGK +S+ I+ YF +
Sbjct: 341 QIKELMQAWQRSEDHKNRDCFVCCILSHGESGA------VYGKDGKLVSIRTIMTYFTAK 394
Query: 265 KLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXX 324
+ P T+ PK+F QAC+G+ VQ P V D V
Sbjct: 395 QCPQLTEKPKLFFVQACQGKE---VQ-----RPV-YVETDARVPDFSSVPQSTSPSESIP 445
Query: 325 EKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLC 359
E+ ++ L+ +T+ G+ S R V+ G+WYIQ LC
Sbjct: 446 EE---ADFLLGMATIDGYASFRHVQEGTWYIQALC 477
>UniRef50_UPI0000D55B5F Cluster: PREDICTED: similar to Caspase
precursor (drICE); n=1; Tribolium castaneum|Rep:
PREDICTED: similar to Caspase precursor (drICE) -
Tribolium castaneum
Length = 309
Score = 79.0 bits (186), Expect = 2e-13
Identities = 61/239 (25%), Positives = 107/239 (44%), Gaps = 28/239 (11%)
Query: 150 YRTRSRKRGVLVVFSYISF-LLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQT 208
Y + RG+ ++F++ F + N++P R G + D L+ + ++GFEV+ +Q+L
Sbjct: 62 YNMNHKNRGLALIFNHEVFDIHNLKP-RTGTDQDRKNLEDVLRKLGFEVIVFQDLRYHDI 120
Query: 209 RATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLP 267
++Q + +C+ + V +HG DT I + + YF + P
Sbjct: 121 ERQIKQAAKYDHTDSDCLCISVLTHG-------DTGILYARDTQYKPDLLWSYFAADRCP 173
Query: 268 NFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKP 327
+ PK+F QAC+G+ D GG L+ + DG + P
Sbjct: 174 SLAGKPKIFFLQACQGDKLD---GGVILS---RTETDGHLEIDSYRI------------P 215
Query: 328 LYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRF 386
++ L+ ST+ G+ S R+ GSW+IQ LCE + D + + T V +R+ F
Sbjct: 216 AQADFLVVYSTVKGYYSWRNTTRGSWFIQALCEELRNKGFDYDLGTILTFVSQRVAFDF 274
>UniRef50_A7S9L1 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 262
Score = 79.0 bits (186), Expect = 2e-13
Identities = 70/271 (25%), Positives = 120/271 (44%), Gaps = 22/271 (8%)
Query: 148 QLYRTRSRKRGVLVVFSYISFLLNIE------PNRDGVNVDCDKLKYLFSEIGFEVLT-Y 200
++Y+ S +G V+F+Y F +++ R G + D L L+ FEV Y
Sbjct: 1 EVYKMTSSPKGYAVIFNYKKFDSSLKFPSEKFDERLGSDKDTASLVRLWKAYDFEVPEPY 60
Query: 201 QNLTLEQTRATLEQMS-SVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVD 259
+L+ ++T+A + +++ + Y+C+ + + SHG E I SDG + + I
Sbjct: 61 LDLSYDETKAAVNKLALKDYSQYDCLAIFLMSHGKE------DFIYTSDGGELKINEIRK 114
Query: 260 YFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXX 319
F+N + + PK+F QACRGE +DF G + P+ +
Sbjct: 115 RFSNARCRSLAGKPKLFFIQACRGEKKDF---GTIVQDGPKTPEEHQETPYKFDLSPHNK 171
Query: 320 XXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVD 379
E ++ L+A ST+ G S R+ GS +I+ L FA + V + T V+
Sbjct: 172 GASTAE---MADFLLAYSTVGGHASFRNTADGSRFIRALVTTFALHSGSEDVLSMLTRVN 228
Query: 380 KRLRLR--FGRQTSSVDRWGFNNKLYLHPGL 408
+ + + G + S KL+L PGL
Sbjct: 229 REVNRQGDIGNKQVSQPETTLTKKLFLWPGL 259
>UniRef50_UPI0000E48555 Cluster: PREDICTED: similar to Lice2
cysteine protease, partial; n=2; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to Lice2 cysteine
protease, partial - Strongylocentrotus purpuratus
Length = 388
Score = 78.6 bits (185), Expect = 3e-13
Identities = 54/213 (25%), Positives = 97/213 (45%), Gaps = 21/213 (9%)
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMS-SVLAGYECVFLVVSSHG 233
NR+G + D + L +FS +GF + +LT+ + R L+++S + +C+ + SHG
Sbjct: 164 NREGTDPDIEGLDRVFSNLGFRTEAHSDLTIAEFRKLLKELSIEDFSNDDCLLFIAMSHG 223
Query: 234 HERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGG 293
E + C DG +++ +V P PK+F QACRG D G
Sbjct: 224 EE------GVLYCRDGT-VAVDELVCRLKGIMCPTLVGKPKLFFIQACRGTQMDH----G 272
Query: 294 ALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSW 353
PA + + P+ ++ L+A S+ PG+ S R ++ GSW
Sbjct: 273 VRVPAGEGDDEPDAALGQKMFYTI---------PVEADFLMAFSSTPGYYSWRSIREGSW 323
Query: 354 YIQVLCEVFAERAHDCHVDELFTLVDKRLRLRF 386
+IQ + +F + V+++ T V++ + R+
Sbjct: 324 FIQAIITIFEKYGTCMDVNQMMTRVNRAVAYRY 356
>UniRef50_Q0WYJ4 Cluster: Caspase 10; n=4; Percomorpha|Rep: Caspase
10 - Paralichthys olivaceus (Japanese flounder)
Length = 494
Score = 77.4 bits (182), Expect = 6e-13
Identities = 59/219 (26%), Positives = 102/219 (46%), Gaps = 24/219 (10%)
Query: 144 SRDIQLYRTRSRKRGV-LVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQN 202
S D+ +Y KRG+ L++ +++ +++P RDG +D + L+ +F +GF+V + N
Sbjct: 236 SEDLGIYPMTEAKRGICLIINNHVFPETSLKP-RDGTMIDEECLRDVFKWLGFDVEVHLN 294
Query: 203 LTLEQTRATLEQMS-SVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYF 261
T E+ + L + CV V SHG E + D K + + +++
Sbjct: 295 CTREKMLSLLWDLGRRDHRQMSCVACFVLSHGLE------GGVHGVDNKIVKINDLMEPL 348
Query: 262 NNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXX 321
N P PK+F QAC+G+ A PA + AV
Sbjct: 349 NAHNCPTLAQKPKLFFIQACQGKKGQSAVYIEADGPATSLICTDAVRDSF---------- 398
Query: 322 XXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCE 360
P+ ++ LI+ +T+P F+S+RD + G+W+IQ LC+
Sbjct: 399 -----PVDADFLISMATVPSFVSYRDKQRGTWFIQSLCK 432
>UniRef50_Q8ITP2 Cluster: AmphiCASP-6; n=2; Chordata|Rep:
AmphiCASP-6 - Branchiostoma floridae (Florida lancelet)
(Amphioxus)
Length = 400
Score = 77.4 bits (182), Expect = 6e-13
Identities = 63/253 (24%), Positives = 103/253 (40%), Gaps = 17/253 (6%)
Query: 142 DVSRDIQLYRTRSRKRGVLVVFSYISFLLNIEPNRD-GVNVDCDKLKYLFSEIGFEVLTY 200
++ +D+ Y +RG+ +VF F + NR G +VD LK +F +GF V
Sbjct: 135 ELLQDLPSYNMNHPQRGLCLVFDNEEFHWTTKMNRRRGSHVDAGNLKVMFEGLGFSVEVL 194
Query: 201 QNLTLEQTRATLEQMSSVL--AGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIV 258
++ + + R L + + +C V SHG D I +G + + +
Sbjct: 195 KDKEITEIRQILHSAALKYDHSQSDCFVCVFLSHGE------DGMIYGYNGT-VPIKELT 247
Query: 259 DYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXX 318
D F + + PK+F QACRG + + P DG
Sbjct: 248 DMFRADRCTSLKGKPKLFFIQACRGAKHE-------IPVEPLDEPDGLEGSGEAEPMDMV 300
Query: 319 XXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLV 378
P ++ L+A S GF SHRD GSWY+Q LC + + V ++ LV
Sbjct: 301 DAGVRPTLPAGADFLMAYSVSEGFYSHRDTVNGSWYVQDLCAALKQHGTNMEVHQILALV 360
Query: 379 DKRLRLRFGRQTS 391
++ + R +T+
Sbjct: 361 NRMVSCREVERTT 373
>UniRef50_Q9Y1U6 Cluster: Cell death protein CED-3; n=1;
Pristionchus pacificus|Rep: Cell death protein CED-3 -
Pristionchus pacificus
Length = 417
Score = 76.6 bits (180), Expect = 1e-12
Identities = 94/414 (22%), Positives = 167/414 (40%), Gaps = 46/414 (11%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
MQ EH+KA+ S + LD ++ L K V + I R S + L R
Sbjct: 5 MQNEHRKALIGFGDSSLPPLYLDPILDYLEVKQVLPESKINEIRRMS----NGRLDLMRS 60
Query: 61 ITRRGPQAF------------TMLLEALREMGHWDLVRDLDPNSPLQLRA------RRPV 102
+T++G AF L ++LR + ++ L+ Q + R
Sbjct: 61 LTKQGSIAFDEFFLSLVHSQQVHLADSLRPLVSQSVIASLENKGTEQKASSSIEGFERME 120
Query: 103 LPPTRQGSDAXXXXXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVV 162
+ R G S + ++K +E + ++Y+ S RG ++
Sbjct: 121 IDEERAGGGGRYDSDGNGKSSFSSFDLRDIEKKLASYE--AQKGERVYQFTS-PRGYALI 177
Query: 163 FSYISFLLNIEPNRDGVNVDCDKLKYLF-SEIGFEVLTYQNLTLEQTRATLEQM-SSVLA 220
S F P R G D LK LF S++G+EV ++NLT ++ ++ SS
Sbjct: 178 ISNEHF--RTMPQRRGTKADVIALKNLFISKLGYEVEVHENLTGKELHNNIKSFASSTKH 235
Query: 221 GYECVFLV-VSSHG-HERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIF 278
+ +V + +HG H+ Y D + + ++ ++ FN P+ PK+ +
Sbjct: 236 SFTSSAIVCILTHGEHDVLYGVDDQV-------VDVHYLLSSFNTHNAPHLAGKPKIILL 288
Query: 279 QACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANST 338
QACRGE +D + ++P S+IL+A +T
Sbjct: 289 QACRGERKDI--------GYEETDSGRPFAFLECLGMGGGGMMTRNKRPAESDILVAYAT 340
Query: 339 LPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGRQTSS 392
++S R+ + GSW+IQ EV +R+HD + + T V+ ++ + +S+
Sbjct: 341 PAHYVSWRNSEKGSWFIQSFVEVAEKRSHDSDLLSILTQVNAKVAETYKANSST 394
>UniRef50_O42284 Cluster: Caspase-1; n=3; Gallus gallus|Rep:
Caspase-1 - Gallus gallus (Chicken)
Length = 283
Score = 76.2 bits (179), Expect = 1e-12
Identities = 71/266 (26%), Positives = 106/266 (39%), Gaps = 17/266 (6%)
Query: 146 DIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTL 205
DI R R +R +L+ + L RDG VD ++ L +G+ V +++ T
Sbjct: 32 DIYQPRERRTRRALLICNTKFKHLRQ----RDGAEVDVKEMTKLLEGLGYNVECHEDKTS 87
Query: 206 EQTRATLEQMSSVLAGY--ECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNN 263
++ +++ + + FLV SHG +D +S I + FNN
Sbjct: 88 QEMTTVMKKFADHKDHLTSDSTFLVFMSHGMSTGICGTKSNGTTD--ILSFNTIYENFNN 145
Query: 264 RKLPNFTDLPKVFIFQACRGENEDFVQGGGALAP-APQVARDGAVXXXXXXXXXXXXXXX 322
+ PKV I Q CRG+N VQ ++ P P DG
Sbjct: 146 KHCRALMGKPKVVIIQCCRGDNIGSVQIRDSIDPEMPTSTSDG-------WRCVELQGSK 198
Query: 323 XXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRL 382
E L S+ S+ P +S R GS +IQ L E F A + + E+F V +
Sbjct: 199 TREAHLESDFATLYSSTPDTVSWRSPTEGSVFIQRLVEQFRNHAFNSDLQEMFRKVQRSF 258
Query: 383 RLRFGRQTSSVDRWGFNNKLYLHPGL 408
F RQ + +R K YL PGL
Sbjct: 259 E-NFPRQLPTQERTTMLKKFYLFPGL 283
>UniRef50_P55865 Cluster: Caspase-1-A precursor; n=3; Xenopus|Rep:
Caspase-1-A precursor - Xenopus laevis (African clawed
frog)
Length = 386
Score = 75.8 bits (178), Expect = 2e-12
Identities = 96/392 (24%), Positives = 164/392 (41%), Gaps = 47/392 (11%)
Query: 29 LYEKGVFSQQMIEPYRDTSITPRERKRILYREITRRGPQAFTMLLEALREMGHWDLVRDL 88
L EK V +E ++++ T R+R R + + ++G +LLE+L + H L + L
Sbjct: 28 LREKNVLVDSEVEHIKESNNTNRDRCRAMIDSVKKKGDDPSNILLESLVK-NHKTLAKSL 86
Query: 89 DPNSPLQLRARRPVLPPTRQGSDAXXXXXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQ 148
+ P P+ P Q +A N IPC + +D I
Sbjct: 87 GLHEP-------PMAPVPIQEHNADTIK---NKDIKGVIPCS--AEEFKKIQDTQGDKIY 134
Query: 149 LYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQT 208
R R ++G+ ++ F N+ R G VD D + L +E+G++V + NLT +
Sbjct: 135 DVRKREGRKGLALIICNEKFE-NLN-ERHGAKVDLDGMTKLLNELGYQVHPHTNLTKTEM 192
Query: 209 RATLEQMSSVL--AGYECVFLVVSSHGHERRYSSDTDIRCSD---GKF-----ISLYAIV 258
+++ ++ A + F+V+ SHG +R+ TD + ++ G++ + + I
Sbjct: 193 VKVMKEFAAQEEHADSDSTFIVLMSHG-DRQGVCGTDSKKTEKEKGQYEVTNLLEIDEIF 251
Query: 259 DYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXX 318
FNN + PKV I QACRGEN+ + +A +P + DG
Sbjct: 252 STFNNVNCSKLRNKPKVIIIQACRGENKGGLLVRDDVA-SPPLEDDGLHFVQRE------ 304
Query: 319 XXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLV 378
++ + S+ P +S RD GS +I L E E AH + ++F V
Sbjct: 305 -----------ADFICFCSSTPDTVSWRDPTKGSVFITHLIEKMNEYAHCQPLGDIFLEV 353
Query: 379 DKRLRLRFGRQTSSV---DRWGFNNKLYLHPG 407
+ + S + +R K YL PG
Sbjct: 354 QSLFKDKCPNSRSQMPTQERCTLTKKFYLFPG 385
>UniRef50_Q92851-2 Cluster: Isoform B of Q92851 ; n=9; Mammalia|Rep:
Isoform B of Q92851 - Homo sapiens (Human)
Length = 479
Score = 74.5 bits (175), Expect = 5e-12
Identities = 55/213 (25%), Positives = 98/213 (46%), Gaps = 26/213 (12%)
Query: 149 LYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQT 208
+YR RG+ V+ + SF +++ +R G + D + L ++F +GF V + N+T +
Sbjct: 232 VYRMNRNHRGLCVIVNNHSFT-SLK-DRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 289
Query: 209 RATLEQM--SSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKL 266
L++ + A +C + +HG R+ + + SD I + I+ +F +
Sbjct: 290 EMVLQKQKCNPAHADGDCFVFCILTHG---RFGA---VYSSDEALIPIREIMSHFTALQC 343
Query: 267 PNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEK 326
P + PK+F QAC+GE + P+ + D
Sbjct: 344 PRLAEKPKLFFIQACQGEE---------IQPSVSIEAD-------ALNPEQAPTSLQDSI 387
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLC 359
P ++ L+ +T+PG++S R V+ GSWYIQ LC
Sbjct: 388 PAEADFLLGLATVPGYVSFRHVEEGSWYIQSLC 420
>UniRef50_Q92851 Cluster: Caspase-10 precursor (EC 3.4.22.63)
(CASP-10) (ICE-like apoptotic protease 4) (Apoptotic
protease Mch-4) (FAS-associated death domain protein
interleukin-1B-converting enzyme 2) (FLICE2) [Contains:
Caspase-10 subunit p23/17; Caspase-10 subunit p12]; n=9;
Eutheria|Rep: Caspase-10 precursor (EC 3.4.22.63)
(CASP-10) (ICE-like apoptotic protease 4) (Apoptotic
protease Mch-4) (FAS-associated death domain protein
interleukin-1B-converting enzyme 2) (FLICE2) [Contains:
Caspase-10 subunit p23/17; Caspase-10 subunit p12] -
Homo sapiens (Human)
Length = 521
Score = 74.5 bits (175), Expect = 5e-12
Identities = 55/213 (25%), Positives = 98/213 (46%), Gaps = 26/213 (12%)
Query: 149 LYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQT 208
+YR RG+ V+ + SF +++ +R G + D + L ++F +GF V + N+T +
Sbjct: 275 VYRMNRNHRGLCVIVNNHSFT-SLK-DRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 332
Query: 209 RATLEQM--SSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKL 266
L++ + A +C + +HG R+ + + SD I + I+ +F +
Sbjct: 333 EMVLQKQKCNPAHADGDCFVFCILTHG---RFGA---VYSSDEALIPIREIMSHFTALQC 386
Query: 267 PNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEK 326
P + PK+F QAC+GE + P+ + D
Sbjct: 387 PRLAEKPKLFFIQACQGEE---------IQPSVSIEAD-------ALNPEQAPTSLQDSI 430
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLC 359
P ++ L+ +T+PG++S R V+ GSWYIQ LC
Sbjct: 431 PAEADFLLGLATVPGYVSFRHVEEGSWYIQSLC 463
>UniRef50_A7S119 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 229
Score = 74.1 bits (174), Expect = 6e-12
Identities = 59/228 (25%), Positives = 98/228 (42%), Gaps = 28/228 (12%)
Query: 156 KRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQM 215
K+G +++ + F + R G D +L LF + G V T QN T + LE+
Sbjct: 1 KKGYVLIINNQEFPSRSDVERKGSAEDVKQLYQLFDDFGMTVKTIQNKTSLEMLELLEET 60
Query: 216 SSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPK 274
S ++C ++ SHG S + I D K + + ++ + F P+ PK
Sbjct: 61 SEKDFTKFDCFICIILSHG------SHSGIYGVDEKAVQVESLTNKFRGSTCPSLQGKPK 114
Query: 275 VFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILI 334
VF QACRG ++ V P P + G P S+ LI
Sbjct: 115 VFFLQACRGAKKELVAVESDSEPVP-IRHSGL--------------------PSDSDFLI 153
Query: 335 ANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRL 382
++ PG+ S+R+ + GSW+I+ + +VF H+ +L V+ R+
Sbjct: 154 CYASSPGYESYRNPELGSWFIRSIVDVFRNFGETEHLMDLMLRVNHRV 201
>UniRef50_UPI0000587146 Cluster: PREDICTED: similar to caspase Xa;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
similar to caspase Xa - Strongylocentrotus purpuratus
Length = 221
Score = 73.7 bits (173), Expect = 8e-12
Identities = 72/242 (29%), Positives = 109/242 (45%), Gaps = 48/242 (19%)
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQ-MSSVLAGYEC--VFLVVSS 231
+R G VD + ++F EIGFE+ T+ +LT EQ + L M S C VF+++
Sbjct: 4 DRTGSEVDVRNIVHVFGEIGFEIETHSDLTAEQLKEKLGMFMKSPCHNGMCSAVFMLM-G 62
Query: 232 HGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQG 291
HG+E T I C + +SL I+ R + + PK+ FQ CRGE G
Sbjct: 63 HGNE------TGIECKHKQIVSLEIIMKQI--RGINSMIGKPKMIFFQCCRGE------G 108
Query: 292 GGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAG 351
G + QV D A+ S++L+ ++T G ++RD G
Sbjct: 109 TGKMEETDQVETDEAIAAK-------------------SDVLMVHATTYGNKAYRDRGKG 149
Query: 352 SWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGRQTSS-------VDRWGFNNKLYL 404
SW+IQ LCE E + H +L T++D R+ + G+ S V + G K+Y
Sbjct: 150 SWFIQKLCE---ELLANAHASDLSTMLD-RVTEQVGKMGSKNKGQCVVVTKQGIRKKIYF 205
Query: 405 HP 406
P
Sbjct: 206 LP 207
>UniRef50_A7SPA7 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 242
Score = 72.9 bits (171), Expect = 1e-11
Identities = 66/241 (27%), Positives = 95/241 (39%), Gaps = 24/241 (9%)
Query: 150 YRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTR 209
Y SR RG+ ++ S F RDG D + LK F + F V Q+ T +
Sbjct: 4 YPMTSRPRGICLIISNQHFDKPELRKRDGNEQDVENLKRTFENLHFVVEIRQDKTASEMY 63
Query: 210 ATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPN 268
+ SS+ + Y+ + SHG I SD I + I F P
Sbjct: 64 TIAREFSSIDHSAYDLFVCCILSHGMLG------SIYGSDSNLIEINEISSQFKGNACPT 117
Query: 269 FTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPL 328
PK+F QACRG +DF +G A A A D +P
Sbjct: 118 LAHKPKLFFIQACRG--QDFDRGIQADATRDMDASDAV---------------RQNAEPN 160
Query: 329 YSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGR 388
S+ L+ +T PG++S R GSWYI LCEV + + + V+ ++ F R
Sbjct: 161 ESHFLLGYATPPGYVSWRSQVHGSWYISFLCEVLSTYCERYDLVTMMVKVNDKVSEAFTR 220
Query: 389 Q 389
+
Sbjct: 221 K 221
>UniRef50_Q7ZXD2 Cluster: MGC53258 protein; n=3; Xenopus|Rep:
MGC53258 protein - Xenopus laevis (African clawed frog)
Length = 419
Score = 72.5 bits (170), Expect = 2e-11
Identities = 77/307 (25%), Positives = 125/307 (40%), Gaps = 37/307 (12%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQM---IEPYRDTSITPRERKRIL 57
MQ+ H+KA+QR SL ++ ++ L + + M I YR + + L
Sbjct: 5 MQQHHRKALQRLRVSLASEMIIEELLDHLVSSEILTNNMHSNIMAYR----SDYAQNVAL 60
Query: 58 YREITRRGPQAFTMLLEALREMGHWDLVRDLDPNSPLQ--------------LRARRPVL 103
+ +RGP+AF+ AL L + ++ + LQ L + L
Sbjct: 61 LNLLPKRGPRAFSAFCNALHSTNQEHLAQQVEKEALLQEEFITSKVHHGSFPLPVQESTL 120
Query: 104 P-PTRQGSDAXXXXXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVV 162
P RQ + PV + S +F+ ++ Q Y+ S RG ++
Sbjct: 121 SRPGRQFCREYREESIDDGDGPVTVQLC----SVNFY---ITHCQQAYKMHSCPRGRALL 173
Query: 163 FSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLA 220
S + F R G VD L+ LFS +G++V NL + + L S+ V +
Sbjct: 174 ISNVKFETPDLDYRCGGEVDLASLEKLFSSLGYQVDVRCNLNAQSMMSQLRAFSALPVHS 233
Query: 221 GYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQA 280
+ + + SHG D + +DGK + L + +N P + PK+F FQA
Sbjct: 234 SLDSCVVAILSHG------LDGAVYGTDGKLVQLQEVFTALDNAHCPQLQNKPKMFFFQA 287
Query: 281 CRGENED 287
CRGE D
Sbjct: 288 CRGEETD 294
>UniRef50_Q9IB62 Cluster: Caspase-10; n=5; Xenopus|Rep: Caspase-10 -
Xenopus laevis (African clawed frog)
Length = 520
Score = 72.1 bits (169), Expect = 2e-11
Identities = 67/246 (27%), Positives = 108/246 (43%), Gaps = 31/246 (12%)
Query: 144 SRDIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNL 203
S ++LY + RG ++ F+ R+G + D L +FS +G EV +NL
Sbjct: 262 SLQMELYHMNHKHRGYCLIIDNSIFMKG--KRREGSDKDAGALSDVFSWLGLEVEIVKNL 319
Query: 204 TLEQTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFN 262
EQ R L++ S + +C + +HG S T + SD K +S+ ++ YF
Sbjct: 320 GTEQIRGCLKRFKSKDHSERDCFVCCILTHGE-----SGT-VMGSDDKEVSIREVMSYFT 373
Query: 263 NRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXX 322
+ T PK+F QAC+G P+ +V D +V
Sbjct: 374 ATSCISLTLKPKLFFIQACQGIYTH---------PSSKVEPDASV--------PVEHKKY 416
Query: 323 XXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAE---RAHDCHVDELFTLVD 379
P ++ L+ ST+ G+ ++R K GSWYIQ LC+ E R D + + T V+
Sbjct: 417 IVNVPKEADFLLGMSTVDGYAAYRHKKYGSWYIQALCKNLVEMVPRGED--ILSILTKVN 474
Query: 380 KRLRLR 385
K + L+
Sbjct: 475 KDVSLK 480
>UniRef50_Q0PKX0 Cluster: Caspase Xa; n=4; Danio rerio|Rep: Caspase
Xa - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 345
Score = 71.7 bits (168), Expect = 3e-11
Identities = 62/230 (26%), Positives = 95/230 (41%), Gaps = 23/230 (10%)
Query: 130 FHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYL 189
F V + F V +++ Y+ RG+ V+ + + F E R G + D L +
Sbjct: 87 FPVLEGHAIFASSV-QEVSQYKITQNPRGICVIINNVDFTSMKE--RRGSDEDQKYLAKV 143
Query: 190 FSEIGFEVLTYQNLTLEQTRATLEQMSSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDG 249
F +GFEV+ ++N T + + L+ + + G +C V SHG + +DG
Sbjct: 144 FRWLGFEVVAHRNKTAAEMKNILQALGRTVDG-DCFVCCVLSHGMKEGVCG------TDG 196
Query: 250 KFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXX 309
+S+ I D F PK+F QACRG + L Q DG
Sbjct: 197 DLVSVDEIRDPFTGINCQKLVGKPKLFFIQACRGLRKQ-------LCVNAQADGDGESEM 249
Query: 310 XXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLC 359
P ++ LIA ST G +S+R+ GSW+IQ LC
Sbjct: 250 EVDGDDFEITI------PSDTDFLIARSTTDGHLSYREPDKGSWFIQSLC 293
>UniRef50_Q3T2L0 Cluster: Caspase-15; n=11; Theria|Rep: Caspase-15 -
Bos taurus (Bovine)
Length = 368
Score = 71.7 bits (168), Expect = 3e-11
Identities = 58/220 (26%), Positives = 97/220 (44%), Gaps = 28/220 (12%)
Query: 167 SFLLNIEPNRDGVNVDCDKLKYLFSEIGFE----VLTYQNLTLEQTRATLEQMSSVLAGY 222
+FL+ ++ NR G + D +K E FE + + L + + ++++ +
Sbjct: 145 AFLMCVKKNRLGAHQDVQLMKDWLKECKFEPTLCIDPDKMDLLGKITSFRDELNEIKDDI 204
Query: 223 ECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACR 282
C + + SHG E I+ DG+ +SL I + FNN+ P + PK+FI QACR
Sbjct: 205 GCCLVTLMSHGEEGF------IKMKDGEKVSLEDIFEMFNNKNCPALQEKPKIFIIQACR 258
Query: 283 GENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGF 342
GE D G P DG+ P +S+ I T
Sbjct: 259 GERRD---SGVETDDEPMDLDDGS---------------EKKRLPTFSDYFIVYPTQADH 300
Query: 343 ISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRL 382
++ RD + GS I+ + EVF + + H+ + FT+V+ R+
Sbjct: 301 VALRDPRTGSVMIKEMTEVFKQYGNKWHLADFFTIVNNRV 340
>UniRef50_Q17FE3 Cluster: Caspase-1; n=3; Endopterygota|Rep:
Caspase-1 - Aedes aegypti (Yellowfever mosquito)
Length = 293
Score = 71.7 bits (168), Expect = 3e-11
Identities = 59/240 (24%), Positives = 109/240 (45%), Gaps = 24/240 (10%)
Query: 148 QLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQ 207
+ Y T +++RG+ +VF +++F ++ R+G + D D + + F+V + +L+ ++
Sbjct: 35 EYYDTTNKRRGIALVFCHMNF--SVMAKRNGADKDRDDICNTLYGLDFDVRVFDDLSRKE 92
Query: 208 TRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKL 266
L+ +S + +C+ +V+ SHG + + D K+ ++ ++ F
Sbjct: 93 VLDRLKDVSREDHSDNDCLVVVMMSHGEQGV------LYARDNKY-NVDSLWKNFVGNAC 145
Query: 267 PNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEK 326
P+ PK+F QACRG E F +G A +P+ D
Sbjct: 146 PSLIGKPKMFFIQACRG--EQFDEGVAYAAKSPKDMVDSRQEQVLYSI------------ 191
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRF 386
P +++L+ ST G+ S R+ + GSW+IQ LC E + L T V +R F
Sbjct: 192 PAMADLLVMYSTYDGYYSWRNPRQGSWFIQSLCTELDENGRVRDLLTLLTGVSRRTAYEF 251
>UniRef50_Q5DD62 Cluster: SJCHGC00800 protein; n=3; Schistosoma
japonicum|Rep: SJCHGC00800 protein - Schistosoma
japonicum (Blood fluke)
Length = 288
Score = 71.3 bits (167), Expect = 4e-11
Identities = 57/227 (25%), Positives = 108/227 (47%), Gaps = 33/227 (14%)
Query: 173 EPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSS 231
+ R+G ++D D+++ +F + ++V N+T + TL + S + Y+ V+ +
Sbjct: 62 QSKRNGTDIDADRIERVFRSLNYKVTRILNITKKALDQTLIEASQKDHSSYDSFVFVMLT 121
Query: 232 HGHERR-YSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
HG + Y+SD +++ S I+ +F + P+ PK+F FQACRG + F +
Sbjct: 122 HGDKDVVYASDDEVQTS--------YIMSFFRGDRCPSLIGKPKLFFFQACRGVS--FDK 171
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
G + A D + + P+ ++IL++ ST+PG+ + R+
Sbjct: 172 GVSTMVAD---AGDDVI---------------VRKLPVEADILVSYSTVPGYFAWRNSTK 213
Query: 351 GSWYIQVLC---EVFAERAHDCHVDELFTLVDKRLRLRFGRQTSSVD 394
GSWYIQ LC E + + + L T+V + + ++ T V+
Sbjct: 214 GSWYIQELCNALETDIKNGNHTDIMTLLTVVARVVAYQYRSSTRQVE 260
>UniRef50_Q07BT4 Cluster: Caspase-1; n=2; Percomorpha|Rep: Caspase-1
- Dicentrarchus labrax (European sea bass)
Length = 394
Score = 69.7 bits (163), Expect = 1e-10
Identities = 64/263 (24%), Positives = 109/263 (41%), Gaps = 10/263 (3%)
Query: 151 RTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRA 210
+T R R L++ + I+F N + NR G D + ++ L +G++V+ NLT ++ A
Sbjct: 137 KTAFRNRVALLITN-ITFT-NEKYNRKGAEKDQENMEKLLKALGYDVVKRTNLTAKEIDA 194
Query: 211 TLEQMSS--VLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPN 268
+ + S L + V +V+ SHG + +F + I ++ + K P
Sbjct: 195 AMIEFSKNPKLRETDSVLVVIMSHGKLGAVLGVNYAEDNPDEF-PINNIYEHLGSEKCPA 253
Query: 269 FTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPL 328
+ PK+ I QACRG V ++ PA + K
Sbjct: 254 LLNKPKIIIIQACRGNAGGAVLVSDSVKPAVLCDDVNQLELSAGEENIEDDTLHFVHKE- 312
Query: 329 YSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLR---LR 385
+ + S+ P +S+R G + IQ + +V AH ++ELF V +R +
Sbjct: 313 -KDFISLLSSTPDTVSYRQPDRGCFLIQYIVDVINTSAHVDDIEELFRTVMQRFEDFPVP 371
Query: 386 FGRQTSSVDRWGFNNKLYLHPGL 408
RQ + DR + Y PGL
Sbjct: 372 NKRQMPTKDRCTLTKRFYFFPGL 394
>UniRef50_A7S4V9 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 358
Score = 69.3 bits (162), Expect = 2e-10
Identities = 63/243 (25%), Positives = 106/243 (43%), Gaps = 30/243 (12%)
Query: 146 DIQLYRTRSRKRGVLVVFSYISFLLNIE-PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLT 204
D +Y+ G ++ + + F + +R G ++D L+ LF + + V +LT
Sbjct: 115 DDDIYKMNRDPHGWCLIINNVRFDADSGLKSRAGSDIDASNLQSLFMSLRYRVKRLNDLT 174
Query: 205 LEQTRATLEQMS-SVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNN 263
+ Q + TL + + + V + + SHG E R I DG +++ ++ FN
Sbjct: 175 MRQMKNTLFDFAKNNHKNSDSVVVCILSHGLEGR------IYGVDGGLLNISDVISMFNG 228
Query: 264 RKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXX 323
+ + PK+F QACRG DF G A Q+
Sbjct: 229 YQAKDLIGKPKLFFLQACRG--GDFDHG----ARMEQI----------------DSPTDK 266
Query: 324 XEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLR 383
P ++ LIA +T+PG++S R + GSW+IQ L EVF A V + V++++
Sbjct: 267 SSLPSEADFLIAYATVPGYVSWRHQEKGSWFIQALVEVFKTDATTEDVLSMLIKVNRKVA 326
Query: 384 LRF 386
L F
Sbjct: 327 LEF 329
Score = 43.2 bits (97), Expect = 0.013
Identities = 21/76 (27%), Positives = 45/76 (59%), Gaps = 1/76 (1%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M+++H+ +++N +L + ++ ++++GVFS++ IE + + +RIL
Sbjct: 1 MEQKHRNLLRKNRVALARDLEPREVLNYIFQEGVFSERDIETVNSLTTRQTQAERIL-DI 59
Query: 61 ITRRGPQAFTMLLEAL 76
+ RRGP+AF + +AL
Sbjct: 60 LPRRGPRAFPVFCDAL 75
>UniRef50_P55210 Cluster: Caspase-7 precursor (EC 3.4.22.60)
(CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3)
(Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7
subunit p20; Caspase-7 subunit p11]; n=58;
Euteleostomi|Rep: Caspase-7 precursor (EC 3.4.22.60)
(CASP-7) (ICE-like apoptotic protease 3) (ICE-LAP3)
(Apoptotic protease Mch-3) (CMH-1) [Contains: Caspase-7
subunit p20; Caspase-7 subunit p11] - Homo sapiens
(Human)
Length = 303
Score = 68.1 bits (159), Expect = 4e-10
Identities = 55/217 (25%), Positives = 92/217 (42%), Gaps = 28/217 (12%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGH 234
R+G + D + L F +GF+V+ Y + + + + L++ S C ++ SHG
Sbjct: 87 RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGE 146
Query: 235 ERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRG-ENEDFVQGGG 293
E I DG + + +F + + PK+F QACRG E +D +Q
Sbjct: 147 ENV------IYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQ--- 196
Query: 294 ALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSW 353
A G + P+ ++ L A ST+PG+ S R GSW
Sbjct: 197 --------ADSGPINDTDANPRYKI--------PVEADFLFAYSTVPGYYSWRSPGRGSW 240
Query: 354 YIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGRQT 390
++Q LC + E D + ++ T V+ R+ F Q+
Sbjct: 241 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQS 277
>UniRef50_Q98UI8 Cluster: Caspase-3; n=4; Chordata|Rep: Caspase-3 -
Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 282
Score = 67.7 bits (158), Expect = 5e-10
Identities = 63/231 (27%), Positives = 101/231 (43%), Gaps = 38/231 (16%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMS----SVLAGYECVFLVVSS 231
R+G +VD + +F ++G+ V Y + T+ Q L ++ S A CV L S
Sbjct: 67 RNGTDVDAGNVMNVFRKLGYIVKVYNDQTVAQIMQVLTTVAHDDHSRCASLVCVLL---S 123
Query: 232 HGHERRY-SSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
HG E + +DT + L ++ F + P+ PK+F QACRG D
Sbjct: 124 HGDEGVFFGTDTSV--------DLKSLTSLFRGDRCPSLVGKPKLFFIQACRGTELD--- 172
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
P V D P+ ++ L A ST+PG+ S R+
Sbjct: 173 --------PGVETD--------HTDHPDIPDGRERIPVEADFLYAYSTVPGYYSWRNTMT 216
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGRQTSSVDRWGFNNK 401
GSW+IQ LCE+ + + + ++ T V+ ++ L F TS++ GF+ K
Sbjct: 217 GSWFIQSLCEMMTKYGSELELLQIMTRVNHKVALDF-ESTSNMP--GFDAK 264
>UniRef50_Q5E9C1 Cluster: Caspase-4 precursor (EC 3.4.22.57)
(CASP-4) [Contains: Caspase-4 subunit 1; Caspase-4
subunit 2]; n=9; Eutheria|Rep: Caspase-4 precursor (EC
3.4.22.57) (CASP-4) [Contains: Caspase-4 subunit 1;
Caspase-4 subunit 2] - Bos taurus (Bovine)
Length = 377
Score = 67.7 bits (158), Expect = 5e-10
Identities = 67/263 (25%), Positives = 104/263 (39%), Gaps = 13/263 (4%)
Query: 148 QLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQ 207
++Y + RK + + + P R+G +D +K L +G+ V + LT
Sbjct: 124 EIYPIKERKDRTRLALIICNTEFDHMPPRNGAALDILGMKQLLEGLGYTVEVEEKLTARD 183
Query: 208 TRATLEQMSS--VLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRK 265
+ L + ++ + FLV SHG + + I FNNR
Sbjct: 184 MESVLWKFAAREEHKSSDSTFLVFMSHGILDGICGTMHSE-EEPDVLPYDTIFRTFNNRN 242
Query: 266 LPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXE 325
+ D PKV I QACRG N +G ++ +P D + E
Sbjct: 243 CLSLKDKPKVIIVQACRGAN----RGELWVSDSPPALAD-SFSQSSENLEEDAVYKTHVE 297
Query: 326 KPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRL-RL 384
K I +ST P +S RD+K GS +I L F + A CH++E+F V + +
Sbjct: 298 KDF---IAFCSST-PHNVSWRDIKKGSLFITRLITCFQKYAWCCHLEEVFRKVQQSFEKP 353
Query: 385 RFGRQTSSVDRWGFNNKLYLHPG 407
Q +V+R YL PG
Sbjct: 354 NVKAQMPTVERLSMTRYFYLFPG 376
>UniRef50_UPI0000E47913 Cluster: PREDICTED: similar to cysteine
protease CPP32 isoform alpha; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to cysteine protease
CPP32 isoform alpha - Strongylocentrotus purpuratus
Length = 505
Score = 66.9 bits (156), Expect = 9e-10
Identities = 60/259 (23%), Positives = 114/259 (44%), Gaps = 21/259 (8%)
Query: 139 FEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEI-GFEV 197
+ED+V D + + RG ++ + +F +R G VD + LF ++
Sbjct: 236 YEDEVFSDDKDDTEYEQGRGYVLFIN--NFFTGKPEHRRGAEVDEKNINNLFKDVLNRYY 293
Query: 198 LTYQ-NLTLEQTRATLEQMSSVLA--GYECVFLVVSSHGHERRYSSDTDIR----CSDGK 250
L Y+ ++T Q + L + L+ Y ++ +HG + +D ++ +D K
Sbjct: 294 LQYEKDVTRSQLQNYLTGLKKTLSTGAYTNFIFILGTHGEPQSNGADRPLKDAVLMADNK 353
Query: 251 FISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXX 310
++ + I+ F+ ++P D PKVFI Q+CRG+ + Q G + + P +
Sbjct: 354 WMLVEDIISNFHGDQIPKMQDKPKVFIIQSCRGKEK---QRGVSSSDGPATELNPETMDY 410
Query: 311 XXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCH 370
+P+ S+ILIA +T + R+ GSW+++ LC V + H
Sbjct: 411 PEPAVTT--------RPVNSDILIAYATSQSKKAFRNQDNGSWFVEDLCNVIRKYYDKEH 462
Query: 371 VDELFTLVDKRLRLRFGRQ 389
+ ++ V+ R+ R Q
Sbjct: 463 ILDILVRVNSRMVKREATQ 481
>UniRef50_A3QVU6 Cluster: Initiator caspase; n=3; Culicidae|Rep:
Initiator caspase - Aedes aegypti (Yellowfever mosquito)
Length = 493
Score = 66.9 bits (156), Expect = 9e-10
Identities = 60/213 (28%), Positives = 93/213 (43%), Gaps = 31/213 (14%)
Query: 169 LLNIEP--NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLAGYECVF 226
LL EP NR G VD + LF+ +G+E + +N+ + +EQ + + C
Sbjct: 272 LLPSEPLKNRRGTEVDKTAILNLFTNLGYEPIVVENIPHLEIMNQVEQAVDRVEPHHCSL 331
Query: 227 LV-VSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGEN 285
++ + SHG E + I +S+ AI RKL T PK+ QAC+G
Sbjct: 332 VICLLSHGQEGKVYGSNSIP------VSVKAIERKMAARKL---TGKPKLLFVQACQGSG 382
Query: 286 EDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISH 345
A+ AP++ DG +Y + L+A ST+PGF S
Sbjct: 383 LQT-----AVDVAPRLEHDGPSSETTAS--------------VYVDFLVAWSTVPGFASI 423
Query: 346 RDVKAGSWYIQVLCEVFAERAHDCHVDELFTLV 378
R ++ GSW+IQ LC + H+ ++ T V
Sbjct: 424 RHIEKGSWFIQELCSKIRQLYERDHLMDILTAV 456
>UniRef50_UPI0000F1EBE3 Cluster: PREDICTED: similar to caspase 10;
n=2; Danio rerio|Rep: PREDICTED: similar to caspase 10 -
Danio rerio
Length = 306
Score = 66.1 bits (154), Expect = 2e-09
Identities = 60/229 (26%), Positives = 101/229 (44%), Gaps = 35/229 (15%)
Query: 147 IQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVD------C-------DKLKYLFSEI 193
++ Y + +RGV ++ + F NR+G ++D C D L+ +F +
Sbjct: 43 VEQYEMKGERRGVCLIINNYDFSACGWLNREGTDIDHAPVSKCVLFYVYSDSLRDVFEWL 102
Query: 194 GFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFI 252
GFE+LT ++ T +Q L +S+ +CV + SHG DI DGK +
Sbjct: 103 GFEILTRRDCTGDQILQALMDLSTQDHTQADCVVCCILSHGRLN------DIIGVDGKAV 156
Query: 253 SLYAIVDYFNNRKLPNFTDLPKVFIFQACRG-ENEDFVQGGGALAPAPQVARDGAVXXXX 311
+++ + + + PK+F QACRG +N+ V +A D V
Sbjct: 157 PFKELMETLSPFRCSSLYQKPKLFFIQACRGTQNQRAVFPQTFTEDEDVLASDAGVPRDS 216
Query: 312 XXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCE 360
P ++ L+A ST+P + S+RD G+W+IQ LC+
Sbjct: 217 I--------------PEMADYLMAMSTVPWYASYRDKSKGTWFIQSLCD 251
>UniRef50_P51878 Cluster: Caspase-5 precursor (EC 3.4.22.58)
(CASP-5) (ICH-3 protease) (TY protease) (ICE(rel)-III)
[Contains: Caspase-5 subunit p20; Caspase-5 subunit
p10]; n=25; Eutheria|Rep: Caspase-5 precursor (EC
3.4.22.58) (CASP-5) (ICH-3 protease) (TY protease)
(ICE(rel)-III) [Contains: Caspase-5 subunit p20;
Caspase-5 subunit p10] - Homo sapiens (Human)
Length = 418
Score = 65.7 bits (153), Expect = 2e-09
Identities = 64/238 (26%), Positives = 94/238 (39%), Gaps = 15/238 (6%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R+G + D +K L +G+ V+ +NLT + L ++ + FLV+ S
Sbjct: 191 PARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMS 250
Query: 232 HGHERRYSSDTDIRCSDGKFISLY-AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
HG + + LY I FNNR + D PKV I QACRGE
Sbjct: 251 HGILEGICGTAHKKKKPD--VLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKH---- 304
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
G L A + E+ + I +ST P +S RD
Sbjct: 305 --GELWVRDSPASLAVISSQSSENLEADSVCKIHEEKDF--IAFCSST-PHNVSWRDRTR 359
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGR-QTSSVDRWGFNNKLYLHPG 407
GS +I L F + + CH+ E+F V K + + Q +++R YL PG
Sbjct: 360 GSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPG 417
>UniRef50_P49662 Cluster: Caspase-4 precursor (EC 3.4.22.57)
(CASP-4) (ICH-2 protease) (TX protease) (ICE(rel)-II)
[Contains: Caspase-4 subunit 1; Caspase-4 subunit 2];
n=10; Mammalia|Rep: Caspase-4 precursor (EC 3.4.22.57)
(CASP-4) (ICH-2 protease) (TX protease) (ICE(rel)-II)
[Contains: Caspase-4 subunit 1; Caspase-4 subunit 2] -
Homo sapiens (Human)
Length = 377
Score = 65.7 bits (153), Expect = 2e-09
Identities = 67/239 (28%), Positives = 99/239 (41%), Gaps = 17/239 (7%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R+G + D +K L + + V +NLT + L ++ + FLV+ S
Sbjct: 150 PPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMS 209
Query: 232 HGH-ERRYSSDTDIRCSDGKFISLY-AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFV 289
HG E + D + D + LY I FNNR + D PKV I QACRG N
Sbjct: 210 HGILEGICGTVHDEKKPD---VLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGAN---- 262
Query: 290 QGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVK 349
+G + +P + + A EK I +ST P +S RD
Sbjct: 263 RGELWVRDSP-ASLEVASSQSSENLEEDAVYKTHVEKDF---IAFCSST-PHNVSWRDST 317
Query: 350 AGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRL-RFGRQTSSVDRWGFNNKLYLHPG 407
GS +I L F + + CH++E+F V + R Q +++R YL PG
Sbjct: 318 MGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPG 376
>UniRef50_Q14790 Cluster: Caspase-8 precursor (EC 3.4.22.61)
(CASP-8) (ICE-like apoptotic protease 5)
(MORT1-associated CED-3 homolog) (MACH) (FADD-homologous
ICE/CED-3-like protease) (FADD-like ICE) (FLICE)
(Apoptotic cysteine protease) (Apoptotic protease Mch-5)
(CAP4) [Contains: Caspase-8 subunit p18; Caspase-8
subunit p10]; n=35; Amniota|Rep: Caspase-8 precursor (EC
3.4.22.61) (CASP-8) (ICE-like apoptotic protease 5)
(MORT1-associated CED-3 homolog) (MACH) (FADD-homologous
ICE/CED-3-like protease) (FADD-like ICE) (FLICE)
(Apoptotic cysteine protease) (Apoptotic protease Mch-5)
(CAP4) [Contains: Caspase-8 subunit p18; Caspase-8
subunit p10] - Homo sapiens (Human)
Length = 479
Score = 65.3 bits (152), Expect = 3e-09
Identities = 56/236 (23%), Positives = 105/236 (44%), Gaps = 28/236 (11%)
Query: 140 EDDVSRDI-QLYRTRSRKRGVLVVFSYISFL--------LNIEPNRDGVNVDCDKLKYLF 190
+D S+ + ++Y+ +S+ RG ++ + +F L+ +R+G ++D L F
Sbjct: 215 QDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTF 274
Query: 191 SEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDG 249
E+ FE+ + + T+EQ L+ + + +C + SHG + I +DG
Sbjct: 275 EELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGI------IYGTDG 328
Query: 250 KFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXX 309
+ +Y + F K P+ PKVF QAC+G+N + +G P + +
Sbjct: 329 QEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDN--YQKG----IPVETDSEEQPYLE 382
Query: 310 XXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAER 365
P ++ L+ +T+ +S+R+ G+WYIQ LC+ ER
Sbjct: 383 MDLSSPQTRYI------PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER 432
>UniRef50_P29466 Cluster: Caspase-1 precursor (EC 3.4.22.36)
(CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1
beta-converting enzyme) (ICE) (Interleukin- 1
beta-converting enzyme) (p45) [Contains: Caspase-1
subunit p20; Caspase-1 subunit p10]; n=29; Eutheria|Rep:
Caspase-1 precursor (EC 3.4.22.36) (CASP-1)
(Interleukin-1 beta convertase) (IL-1BC) (IL-1
beta-converting enzyme) (ICE) (Interleukin- 1
beta-converting enzyme) (p45) [Contains: Caspase-1
subunit p20; Caspase-1 subunit p10] - Homo sapiens
(Human)
Length = 404
Score = 65.3 bits (152), Expect = 3e-09
Identities = 91/404 (22%), Positives = 153/404 (37%), Gaps = 27/404 (6%)
Query: 15 SLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYREITRRGPQAFTMLLE 74
S+ EGT ++ ++ L + V +++ +E + + T ++ R L + +G QA + +
Sbjct: 16 SMGEGT-INGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICIT 74
Query: 75 ALRE-----MGHWDLVRDLDPNSPLQLRARRPVLP--PTRQGSDAXXXXXXXNSSEPVAI 127
+ E G L D + L ++ + VL P Q + SE
Sbjct: 75 YICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVK 134
Query: 128 PCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLK 187
C ++++ ++ + + SR R L++ + + P R G VD +
Sbjct: 135 LC-SLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEE---FDSIPRRTGAEVDITGMT 190
Query: 188 YLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSSHG-HERRYSSDTDI 244
L +G+ V +NLT LE + + FLV SHG E
Sbjct: 191 MLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSE 250
Query: 245 RCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARD 304
+ D + L AI + N + P+ D PKV I QACRG++ V ++
Sbjct: 251 QVPD--ILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSV--------- 299
Query: 305 GAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAE 364
G + + + + S+ P +S R GS +I L E E
Sbjct: 300 GVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQE 359
Query: 365 RAHDCHVDELFTLVDKRLRLRFGR-QTSSVDRWGFNNKLYLHPG 407
A C V+E+F V GR Q + +R YL PG
Sbjct: 360 YACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPG 403
>UniRef50_UPI00015553DC Cluster: PREDICTED: similar to caspase-15;
n=1; Ornithorhynchus anatinus|Rep: PREDICTED: similar to
caspase-15 - Ornithorhynchus anatinus
Length = 237
Score = 64.5 bits (150), Expect = 5e-09
Identities = 57/220 (25%), Positives = 91/220 (41%), Gaps = 27/220 (12%)
Query: 167 SFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQN----LTLEQTRATLEQMSSVLAGY 222
+FL+ ++ R G D +KL+ + F V + + L+ R ++++
Sbjct: 7 AFLMGVKKGRSGATEDIEKLRKHLAAFRFSVQECIDPDGKVILQDLREFRDKINGSPYEM 66
Query: 223 ECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACR 282
C +++ SHG + I+ D K + L I FNN PN + PK+FI QACR
Sbjct: 67 SCCLVILMSHG------VNGFIKGKDEKVVDLEEIFKLFNNANCPNLREKPKIFIIQACR 120
Query: 283 GENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGF 342
G+ D G A P+ D P S+ I ST G
Sbjct: 121 GDRTD--GGVEAFDNVPEEMDD---------------TSNVKRLPTTSDFFIVYSTQKGH 163
Query: 343 ISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRL 382
+S R+ GS I+ + +VF+ + +LFT V+ L
Sbjct: 164 VSVRNPLMGSRMIEAMDDVFSRYGKKWQLTDLFTKVNDEL 203
>UniRef50_UPI0000661247 Cluster: Homolog of Brachydanio rerio
"Caspase.; n=4; Takifugu rubripes|Rep: Homolog of
Brachydanio rerio "Caspase. - Takifugu rubripes
Length = 358
Score = 64.5 bits (150), Expect = 5e-09
Identities = 62/240 (25%), Positives = 96/240 (40%), Gaps = 18/240 (7%)
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSSH 232
NR G D + ++ L +G+EV+ Y+NLT + S L + V +V+ SH
Sbjct: 130 NRKGAEKDEENMETLLKGLGYEVVKYRNLTGRAIEDAVIDFSKRPKLKDTDSVVVVIMSH 189
Query: 233 GHERRYSS-DTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQG 291
G + T + SL I + P + PK+ I QACRG+ +
Sbjct: 190 GRLGVVAGVSTQSPTFEDDLFSLDKIYRHLGPEHCPALLNKPKIIIIQACRGDERGEIIF 249
Query: 292 GGALAPA-PQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
P P V+ D + EK + + S P +S+R +
Sbjct: 250 NDQHPPENPPVSDDANI-------QEDAIRIEHKEK----DFIWLLSCTPDTVSYRALAK 298
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLVDKRLR---LRFGRQTSSVDRWGFNNKLYLHPG 407
GS+ +QVL +VF A ++ELF V R + RQ + DR + Y +PG
Sbjct: 299 GSFLVQVLVDVFNASAERDDLEELFRKVQHRFEDFPIGNRRQMPTRDRCTLTKRFYFYPG 358
>UniRef50_UPI0000F2DFE7 Cluster: PREDICTED: similar to apoptotic
cysteine protease proMch4; n=1; Monodelphis
domestica|Rep: PREDICTED: similar to apoptotic cysteine
protease proMch4 - Monodelphis domestica
Length = 452
Score = 64.1 bits (149), Expect = 6e-09
Identities = 56/217 (25%), Positives = 90/217 (41%), Gaps = 25/217 (11%)
Query: 145 RDIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLT 204
++ + YR RG ++F+ F R G D D+LK +F +GF V + N
Sbjct: 201 QEAKFYRMDHSHRGHCIIFNNFEF--QTMKRRRGSCKDADELKSVFEWLGFTVKIHPNTE 258
Query: 205 LEQTRATLEQMSSVLAGYE--CVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFN 262
+ L+Q S+ E C V +HG S SD + I++ + YF
Sbjct: 259 KREMEDILQQCSTSPEHRESDCFVCCVLTHGESGSVFS------SDEEKIAIRELTSYFK 312
Query: 263 NRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXX 322
+ P + PK+F FQAC+G + +Q L +++ V
Sbjct: 313 AHRCPGLANKPKLFFFQACQGPD---IQESMLLEEDAKISPPIQVETPQRYI-------- 361
Query: 323 XXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLC 359
P+ ++ L+ +T+ G + R GSWYIQ LC
Sbjct: 362 ----PVEADFLLGMATVDGCCAIRHTIKGSWYIQALC 394
>UniRef50_UPI0000F21D96 Cluster: PREDICTED: hypothetical protein,
partial; n=1; Danio rerio|Rep: PREDICTED: hypothetical
protein, partial - Danio rerio
Length = 170
Score = 63.7 bits (148), Expect = 8e-09
Identities = 41/141 (29%), Positives = 67/141 (47%), Gaps = 8/141 (5%)
Query: 148 QLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQ 207
Q Y + KRG+ ++F+ F L R G + D D L F E+ FEV Y + + ++
Sbjct: 16 QEYDMKHAKRGMALIFNQKDFSLLGLKTRKGTDKDRDSLVSRFEELDFEVKAYNDYSRDK 75
Query: 208 TRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKL 266
++++++ +C + SHG D + D K I + I D F K
Sbjct: 76 VLREIKEVAAADHVDADCFVCIFLSHGE------DGHVYARDKK-IKIPEITDLFKGDKC 128
Query: 267 PNFTDLPKVFIFQACRGENED 287
+ PK+FI+QACRG+ +D
Sbjct: 129 RSLVGKPKIFIWQACRGDKKD 149
>UniRef50_P29466-2 Cluster: Isoform Beta of P29466 ; n=11;
Theria|Rep: Isoform Beta of P29466 - Homo sapiens
(Human)
Length = 383
Score = 62.5 bits (145), Expect = 2e-08
Identities = 90/397 (22%), Positives = 150/397 (37%), Gaps = 34/397 (8%)
Query: 15 SLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYREITRRGPQAFTMLLE 74
S+ EGT ++ ++ L + V +++ +E + + T ++ R L + +G QA + +
Sbjct: 16 SMGEGT-INGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICIT 74
Query: 75 ALREMGHWDLVRDLDPNSPLQLRARRPVLPPTRQGSDAXXXXXXXNSSEPVAIPCFHVKK 134
+ E + L L ++ Q P +P T GS+ ++ + +K
Sbjct: 75 YICEEDSY-LAGTLGLSAAPQAVQDNPAMP-TSSGSEGNVKLCSLEEAQRI-----WKQK 127
Query: 135 STHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIG 194
S + + SR R L++ + + P R G VD + L +G
Sbjct: 128 SAEIYP--------IMDKSSRTRLALIICNEE---FDSIPRRTGAEVDITGMTMLLQNLG 176
Query: 195 FEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSSHG-HERRYSSDTDIRCSDGKF 251
+ V +NLT LE + + FLV SHG E + D
Sbjct: 177 YSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPD--I 234
Query: 252 ISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXX 311
+ L AI + N + P+ D PKV I QACRG++ V ++ G
Sbjct: 235 LQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSV---------GVSGNLS 285
Query: 312 XXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHV 371
+ + + + S+ P +S R GS +I L E E A C V
Sbjct: 286 LPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDV 345
Query: 372 DELFTLVDKRLRLRFGR-QTSSVDRWGFNNKLYLHPG 407
+E+F V GR Q + +R YL PG
Sbjct: 346 EEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPG 382
>UniRef50_Q6KF63 Cluster: Caspase 10; n=3; Catarrhini|Rep: Caspase
10 - Homo sapiens (Human)
Length = 455
Score = 62.5 bits (145), Expect = 2e-08
Identities = 45/176 (25%), Positives = 78/176 (44%), Gaps = 24/176 (13%)
Query: 186 LKYLFSEIGFEVLTYQNLTLEQTRATLEQM--SSVLAGYECVFLVVSSHGHERRYSSDTD 243
L ++F +GF V + N+T + L++ + A +C + +HG R+ +
Sbjct: 243 LSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHG---RFGA--- 296
Query: 244 IRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVAR 303
+ SD I + I+ +F + P + PK+F QAC+GE + P+ +
Sbjct: 297 VYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEE---------IQPSVSIEA 347
Query: 304 DGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLC 359
D P ++ L+ +T+PG++S R V+ GSWYIQ LC
Sbjct: 348 D-------ALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLC 396
>UniRef50_Q5D0W5 Cluster: Caspase 3C; n=2; Hydra vulgaris|Rep:
Caspase 3C - Hydra attenuata (Hydra) (Hydra vulgaris)
Length = 326
Score = 62.1 bits (144), Expect = 3e-08
Identities = 69/260 (26%), Positives = 115/260 (44%), Gaps = 43/260 (16%)
Query: 150 YRTRSRKRGVLVVFSYISFLLNIEPNRD---GVNVDCDKLKYLFSEIGFEVLTYQNLTLE 206
Y T + RG L + + +F+ + + D G +VD L LF ++GF++ N
Sbjct: 76 YDTNTFPRGTLTIINVNNFMKSSGRHDDPRLGTDVDAQSLCDLFLKLGFKIDRLDNPKST 135
Query: 207 QTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRK 265
L+Q ++ + C + + SHG E + I C++ + +++ I + F
Sbjct: 136 DVLNILKQAANEDYSSMSCCVVALLSHGEEGK------IFCTN-ESLNIREITNLFCTNA 188
Query: 266 LPNFTDLPKVFIFQACRG----ENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXX 321
L PK+F+ QACRG E+ D V G G P ++ + V
Sbjct: 189 LAG---KPKLFLIQACRGTKYMESIDTVDGFG-----PGLSNESNVL------------- 227
Query: 322 XXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKR 381
+ + S+ L A ST+ + S R+ K GSW+I + VF + AH V L T V+K
Sbjct: 228 ---DVTVESDFLYAYSTVQSYYSWRNQKLGSWFINAVVSVFRDYAHKMDVLRLLTRVNKE 284
Query: 382 LRLRFGRQTSSVDRWGFNNK 401
+ ++TS D +NK
Sbjct: 285 V----SKKTSITDNLTKDNK 300
>UniRef50_UPI0000E472FD Cluster: PREDICTED: similar to caspase 8;
n=2; Strongylocentrotus purpuratus|Rep: PREDICTED:
similar to caspase 8 - Strongylocentrotus purpuratus
Length = 790
Score = 61.7 bits (143), Expect = 3e-08
Identities = 53/218 (24%), Positives = 97/218 (44%), Gaps = 34/218 (15%)
Query: 146 DIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLF-SEIGFEVLTYQNLT 204
D+ Y+ RG+ ++F+ +F RDG D + L F + + F++ Q+ T
Sbjct: 424 DLPKYKMDRLPRGLCIIFNAENFTRKNLHKRDGTEKDVEALLNTFQNRLKFKIRVEQDPT 483
Query: 205 LEQTRATLEQMS-SVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNN 263
++ L++++ S + Y+C ++ SHG + + +DG+ + + A+ F
Sbjct: 484 ADKYLKCLQEIARSDHSEYDCFVCIILSHGCKGH------VYGTDGRLMPIDALTGLFRG 537
Query: 264 RKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXX 323
+P+ + PK+F QAC QG A A + +D
Sbjct: 538 EYVPSLVNKPKLFFIQAC--------QGDNAQR-AVDIQQDATTTL-------------- 574
Query: 324 XEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEV 361
P S+ L++ ST+ G+ S+R V G+W+I LC V
Sbjct: 575 ---PNESDTLVSMSTVSGYASNRSVSQGTWFISSLCMV 609
Score = 41.1 bits (92), Expect = 0.051
Identities = 21/58 (36%), Positives = 35/58 (60%), Gaps = 3/58 (5%)
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVD--ELFTLVDKRL 382
P S+ L++ ST+PG+ S+R V G+W+I LC + + +VD + TLV++ L
Sbjct: 703 PNESDTLVSMSTVPGYASNRSVSQGTWFITALCSII-NTYYKKNVDLLSMLTLVNEML 759
>UniRef50_UPI0000F2CF2D Cluster: PREDICTED: similar to
evolutionarily related interleukin-1beta converting
enzyme; n=1; Monodelphis domestica|Rep: PREDICTED:
similar to evolutionarily related interleukin-1beta
converting enzyme - Monodelphis domestica
Length = 372
Score = 60.9 bits (141), Expect = 6e-08
Identities = 62/283 (21%), Positives = 114/283 (40%), Gaps = 20/283 (7%)
Query: 128 PCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLK 187
P H KK F +++ + + RKR L++ + I F E R G VD ++
Sbjct: 106 PPEHFKK---FMKENEEKIYPVKEKEGRKRLALIICN-IEFTYYSE--RTGAEVDIKGME 159
Query: 188 YLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLA--GYECVFLVVSSHGHERRYSSDTDIR 245
L ++G+ V ++LT + + L + ++ + F+V+ SHG +
Sbjct: 160 GLLKDLGYTVDVQRDLTSSEMASELRKFAARQEHESSDSTFVVLMSHGILDAICGKNHKK 219
Query: 246 CSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDG 305
+ + I + N + P D PKV I QACRG G + +P+++ D
Sbjct: 220 -EEPDVLPYDTIFNILNTKNCPKLKDKPKVIIIQACRGVK----SGKVLMRDSPEISEDS 274
Query: 306 AVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAER 365
+ E + + + S+ P +S RD + GS +I + + +
Sbjct: 275 EI------NPELLEEDAIFETHVEKDFISFFSSTPNNVSWRDHENGSIFIIKVIDYIQKY 328
Query: 366 AHDCHVDELFTLVDKRL-RLRFGRQTSSVDRWGFNNKLYLHPG 407
+ CH+ ++F V + Q +++R YL PG
Sbjct: 329 SWCCHLVDIFQKVQRAFDTANVKLQMPTIERMTMTKNFYLFPG 371
>UniRef50_UPI0000F2CF2E Cluster: PREDICTED: similar to caspase 12;
n=1; Monodelphis domestica|Rep: PREDICTED: similar to
caspase 12 - Monodelphis domestica
Length = 405
Score = 60.5 bits (140), Expect = 8e-08
Identities = 58/245 (23%), Positives = 96/245 (39%), Gaps = 12/245 (4%)
Query: 167 SFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYEC 224
+ L + R G +D + L +G+ V+ NLT ++ + L++ + +
Sbjct: 170 NILFDYLDERQGAYLDIWGMWKLLENLGYTVIIKTNLTAQKMESVLKEFADRPEHLSSDS 229
Query: 225 VFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGE 284
FLV SHG + ++ I FN+ P+ PKV I QACRGE
Sbjct: 230 TFLVFMSHGLLNGICGIEHTK-QKPDLLATDVIFQIFNDSNCPSLKGKPKVIIIQACRGE 288
Query: 285 NEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFIS 344
G + P + + +K L + + ST P +S
Sbjct: 289 K----LGITYVMDTP----ESSAGTPDQPMEDHSGNNPLEQKLLEKDFISFCSTTPHNVS 340
Query: 345 HRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRL-RFGRQTSSVDRWGFNNKLY 403
R GS +I L F + A CH++E+F V K + + Q +++R + Y
Sbjct: 341 WRVDILGSVFINELIYCFQQYAWCCHLEEIFRKVQKSFEIPKILVQMPTIERQSISRYFY 400
Query: 404 LHPGL 408
L PG+
Sbjct: 401 LFPGI 405
>UniRef50_Q9TZP6 Cluster: Caspase-related protein 1B; n=3;
Caenorhabditis elegans|Rep: Caspase-related protein 1B -
Caenorhabditis elegans
Length = 268
Score = 59.7 bits (138), Expect = 1e-07
Identities = 56/227 (24%), Positives = 94/227 (41%), Gaps = 14/227 (6%)
Query: 150 YRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTR 209
Y S RG +++ S +F N+E R G D L LF ++ + V+ +NL E
Sbjct: 17 YEMNSNPRGTVLILSNENFK-NME-RRVGTKQDEVNLTKLFQKLQYTVICKRNLEAESML 74
Query: 210 ATLEQMSSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNF 269
+++ + +A + + L + SHG D + +S Y + Y N L
Sbjct: 75 EAIKEFAE-MAHTDSIILFLLSHGDGAGSVFGIDDMPVNVMEVSTY--LAYHQNLLLK-- 129
Query: 270 TDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLY 329
PK ACRG + G D L
Sbjct: 130 ---PKWVAVSACRGGKLNM----GVPVDGLPALEDKCAPISKFWNLMMSRIMPGTFTSLN 182
Query: 330 SNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFT 376
++++I+ ST GF S+RD +AG+WYI+ +C+VF + + H+ ++ T
Sbjct: 183 ADVIISFSTTDGFTSYRDEEAGTWYIKSMCKVFNKHSKTMHLLDILT 229
>UniRef50_Q9NHF9 Cluster: Caspase 6-like protein BG2; n=3;
Sophophora|Rep: Caspase 6-like protein BG2 - Drosophila
melanogaster (Fruit fly)
Length = 308
Score = 59.7 bits (138), Expect = 1e-07
Identities = 51/196 (26%), Positives = 80/196 (40%), Gaps = 19/196 (9%)
Query: 173 EPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSS 231
+ R G D D ++ GF+V T+ +LT + TL++++ + +C L V S
Sbjct: 69 QKQRVGTERDRDDMEATLQGFGFDVRTFDDLTFSEINDTLKEVAREDHSQNDCFVLAVMS 128
Query: 232 HGHERR-YSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
HG E + Y+ D + + + F + PK+F QACRG N
Sbjct: 129 HGTEGKVYAKDMSY--------PVERLWNPFLGDNCKTLKNKPKLFFIQACRGAN----- 175
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
L A + + + P ++IL+ ST F S R+V
Sbjct: 176 ----LEKAVEFSSFAVMTRELVPEPAAAVQPITYAIPSTADILVFYSTFDKFFSFRNVDD 231
Query: 351 GSWYIQVLCEVFAERA 366
GSW+IQ LC V + A
Sbjct: 232 GSWFIQSLCRVLDQAA 247
>UniRef50_UPI0000D56041 Cluster: PREDICTED: similar to CG7486-PB,
isoform B; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG7486-PB, isoform B - Tribolium castaneum
Length = 568
Score = 59.3 bits (137), Expect = 2e-07
Identities = 49/203 (24%), Positives = 82/203 (40%), Gaps = 23/203 (11%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLAGYECVFLVVSSHGHE 235
R G D DKL+ F + GF+ + NLT + +E++ + +F+ + SHG
Sbjct: 352 RIGTQYDRDKLEATFRQFGFKTIVENNLTHLEMLRKIEEVVQSVNDESSLFISIMSHGDV 411
Query: 236 RRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGAL 295
+ + + AI + P+ + PKV I Q+C+G +Q
Sbjct: 412 GVVYGVNSCQ------VDVKAIKRVMCTKNRPHLSGKPKVLILQSCQGTRCQKIQSDD-- 463
Query: 296 APAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYI 355
+ DG P +++ +T+PG+ + R+ K GSW+I
Sbjct: 464 ---DDIETDGP------------SSPVQESVPPIADLFTFWATVPGYGAIRNKKTGSWFI 508
Query: 356 QVLCEVFAERAHDCHVDELFTLV 378
Q LC E H H D++ T V
Sbjct: 509 QSLCGKMKELGHKYHFDDICTSV 531
>UniRef50_Q9GV89 Cluster: Caspase 3A; n=1; Hydra vulgaris|Rep:
Caspase 3A - Hydra attenuata (Hydra) (Hydra vulgaris)
Length = 347
Score = 59.3 bits (137), Expect = 2e-07
Identities = 54/188 (28%), Positives = 79/188 (42%), Gaps = 27/188 (14%)
Query: 173 EPNRDGVNVDCDKLKYLFS-EIGFEVLTYQNLTLEQTRATLEQMSSVLA-GYECVFLVVS 230
E NRDG VD L F +G+ V + NL E + +S V + +F+V+
Sbjct: 106 EENRDGSEVDVQALNSFFKGTLGWCVKSCNNLKREDIINIVYSLSQVKCFPFSALFIVIL 165
Query: 231 SHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
SHG E S I S+ I + ++++ F P F PKVFI QACRGE +D
Sbjct: 166 SHGSE---SGILGIDSSEE--IKINSLLENFKADNAPAFDKKPKVFIVQACRGEKDD--- 217
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
+ +DG P+ S+ ++A G+ + R
Sbjct: 218 ----------IRKDGIKDAKRTYYNESTI-------PMLSDFVVAYPCAAGYTALRSTVK 260
Query: 351 GSWYIQVL 358
GSW+IQ L
Sbjct: 261 GSWFIQEL 268
>UniRef50_Q56VC9 Cluster: Caspase-8; n=3; Euteleostei|Rep: Caspase-8
- Oryzias latipes (Medaka fish) (Japanese ricefish)
Length = 481
Score = 58.4 bits (135), Expect = 3e-07
Identities = 56/229 (24%), Positives = 91/229 (39%), Gaps = 20/229 (8%)
Query: 148 QLYRTRSRKRGVLVVFSYISFLLNIE-PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLE 206
+ Y RG+ V+F+ F R G D L LF GFEV+ + NLT +
Sbjct: 232 EYYSFTHEPRGLCVIFNNKLFFPESNLGERGGTEKDEKSLNNLFHRFGFEVVVHNNLTAD 291
Query: 207 QTRATLEQMSSVLAGYECVFLV-VSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRK 265
+ + ++ ++ +V V SHG + + DGK + L A+ F + +
Sbjct: 292 LIESEITKLGQRNFSHDDALVVCVLSHG------DNGCVYGIDGKKVQLRALTLPFPSYR 345
Query: 266 LPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXE 325
P+ PK+F QAC+G Q G P +V D +
Sbjct: 346 APSLIGKPKLFFIQACQG---TLAQSG--YLPGSEVKGDAELEADASSSTSNSV------ 394
Query: 326 KPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDEL 374
P ++ L+ +T+ S R+ GS YIQ LC A ++++
Sbjct: 395 -PNDADFLLGMATVAECKSFRNKYTGSIYIQELCRQLERAAESSKMEDI 442
>UniRef50_Q4SNC6 Cluster: Chromosome 8 SCAF14543, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 8
SCAF14543, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 397
Score = 58.4 bits (135), Expect = 3e-07
Identities = 73/306 (23%), Positives = 128/306 (41%), Gaps = 31/306 (10%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMA-LYEKGVFSQQMIEPYRDTSITPRERKRILYR 59
M E +A+++ + L + +D +++ L + + M E + + ++L+
Sbjct: 3 MVERDAQALKKQSAVLFKQLVVDELLIQFLQADDILTDSMAESILAEQTSHKRCWKLLHL 62
Query: 60 EITRRGPQAFTMLLEALREMGHWDL----VRDLDPN---SPLQLRARRPVLPPTRQGSDA 112
+ +RGP+AF+ ALRE L R N + L+ V PT++ A
Sbjct: 63 -LPKRGPKAFSSFCSALRETDQKHLCDLLARTSQENGNGTHLETCVDSSVPLPTQEAVPA 121
Query: 113 XXXXX------XXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYI 166
++ P+ P V T F S+ Q Y+ S RG+ +V S +
Sbjct: 122 KRARTQESMEISLDADSPINTP---VCPCTPDFYHSHSQ--QSYKMTSSPRGLALVISNV 176
Query: 167 SFLLNIEPN---RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAG 221
F P+ R G VD + L+ +F+E+ + V ++LT + + +E S
Sbjct: 177 RFSPFAAPDLDPRQGGEVDDEVLRKVFTELDYLVTVQRDLTAQGIKTCIENFSRRPEHQS 236
Query: 222 YECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQAC 281
+ + + SHG E + DGK + L + F+N P + PK+F QAC
Sbjct: 237 VDSCVVCLLSHGVEGA------VYGVDGKLLQLDWVFTAFDNAHCPLLQNKPKMFFIQAC 290
Query: 282 RGENED 287
RG+ D
Sbjct: 291 RGDEMD 296
>UniRef50_Q09HM6 Cluster: Caspase-8; n=1; Molgula tectiformis|Rep:
Caspase-8 - Molgula tectiformis
Length = 700
Score = 58.4 bits (135), Expect = 3e-07
Identities = 47/185 (25%), Positives = 77/185 (41%), Gaps = 21/185 (11%)
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHG 233
NR G +D D ++ +F+ F+V +L + + +++ S + + Y+ V+ SHG
Sbjct: 458 NRAGSKIDADAIEDIFTGFSFKVHRCNDLKHREMQICIQEFSEMDHSKYDSFVCVILSHG 517
Query: 234 HERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGG 293
S DG + I +F D PK+ QAC G NE ++G
Sbjct: 518 KRNIVYS------VDGYKFRISDIQSFFTTTTCSTLQDKPKLVFIQACAGANE--MEG-- 567
Query: 294 ALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSW 353
Q ++ + P ++ L+ANST PG+ S+R K GSW
Sbjct: 568 ---KEIQCQQESDIHSDGDDNIKEAT-------PFLADFLLANSTWPGYRSYRSTKTGSW 617
Query: 354 YIQVL 358
+I L
Sbjct: 618 FITAL 622
>UniRef50_Q7Q802 Cluster: ENSANGP00000021365; n=4; Cellia|Rep:
ENSANGP00000021365 - Anopheles gambiae str. PEST
Length = 296
Score = 57.6 bits (133), Expect = 6e-07
Identities = 55/234 (23%), Positives = 98/234 (41%), Gaps = 27/234 (11%)
Query: 150 YRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTR 209
Y T R+RG+ ++ ++ +F + R+G N D D + + + F+V Y +L ++
Sbjct: 50 YDTNHRRRGMAIILNHENF--ELMSKREGTNRDRDAATAVLTSMQFDVRVYNDLGRDELF 107
Query: 210 ATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPN 268
L ++S + +C+ +++ +HG D + DG + S+ + + F
Sbjct: 108 CVLLALASEDHSDCDCLLVMLMTHG------DDDVLYAYDGPY-SVDKLWESFMGNACTT 160
Query: 269 FTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPL 328
PK+F QACRG D G L RD P
Sbjct: 161 LLGKPKLFFVQACRGSTFD---KGVKLG-----CRD---------LDSDHFSSHKYVIPT 203
Query: 329 YSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRL 382
+++L+ S+ G +S R + GSW+IQ LC + +L T V +R+
Sbjct: 204 TADLLVMYSSYKGHVSWRSPRGGSWFIQALCVELETNWKHMELLQLLTGVSRRV 257
>UniRef50_Q9Y055 Cluster: Caspase-related protein 2A; n=3;
Caenorhabditis elegans|Rep: Caspase-related protein 2A -
Caenorhabditis elegans
Length = 826
Score = 57.2 bits (132), Expect = 7e-07
Identities = 53/209 (25%), Positives = 86/209 (41%), Gaps = 20/209 (9%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLAGYECVFLVVSSHGHE 235
R G + D KL LF +G++ +Y NL + T+ Q + G + + + + SHG +
Sbjct: 605 RIGSDKDKKKLSKLFERLGYQSTSYDNLKSSEILETVRQFTQSNHG-DSLIITIMSHGDQ 663
Query: 236 RRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENED-FVQGGGA 294
DG + + I+D L PK + CRG+ D V+ G
Sbjct: 664 GLLYG------VDGVPVQMLDIIDLMCTASLAK---KPKWLMCVCCRGDRIDRAVRCDGF 714
Query: 295 LAPAPQVARDGAVXXXXXXXXXXXXXXXXXE-KPLYSNILIANSTLPGFISHRDVKAGSW 353
+ D + +++L++ ST PGF+S RD G+W
Sbjct: 715 I--------DNFFDRFPKFFQFMKSKFPSHQTSSSQADLLVSFSTSPGFLSFRDETKGTW 766
Query: 354 YIQVLCEVFAERAHDCHVDELFTLVDKRL 382
YIQ L V E A D H+ +L ++R+
Sbjct: 767 YIQELYRVIIENAKDTHLADLLMETNRRV 795
>UniRef50_Q4RG79 Cluster: Chromosome 2 SCAF15106, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 2 SCAF15106, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 242
Score = 56.8 bits (131), Expect = 1e-06
Identities = 52/217 (23%), Positives = 85/217 (39%), Gaps = 13/217 (5%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGH 234
R+G + D +L F +GF+V Y + T E+ L + S + C ++ SHG
Sbjct: 4 RNGTDRDAGELYKCFKSLGFDVFIYNDQTCEKMEHLLREASEEDHSDSSCFACILLSHGE 63
Query: 235 ERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQ-ACRGENEDFVQGGG 293
E I +DG + + + F + PK+F Q + +D +
Sbjct: 64 EGM------IYGTDGA-MPIKTMTSMFRGDMCKSLVGKPKLFFIQFSAETATQDHNEMSS 116
Query: 294 AL---APAPQVARDGAVXXXXXXXXXXXXXXXXXEK-PLYSNILIANSTLPGFISHRDVK 349
L A DG K P+ ++ L A ST+PG+ S R+
Sbjct: 117 HLLHQACRGSEFDDGIQTDSGPPNDTMETDANPRHKIPVEADFLFAYSTVPGYYSWRNPG 176
Query: 350 AGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRF 386
GSW++Q LC V E + ++ T V+ + F
Sbjct: 177 RGSWFVQALCNVLNEFGKQLEIMQILTRVNYMVATSF 213
>UniRef50_Q4JQQ0 Cluster: Initiator caspase; n=2; Gallus gallus|Rep:
Initiator caspase - Gallus gallus (Chicken)
Length = 464
Score = 56.4 bits (130), Expect = 1e-06
Identities = 48/215 (22%), Positives = 88/215 (40%), Gaps = 24/215 (11%)
Query: 147 IQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLE 206
++ Y+ + G V+ + F N R G D LK +F + F+ + Y +L +
Sbjct: 213 VESYKMENNPHGYCVILNNYRFK-NPNETRKGTVEDGKALKRVFKWLQFDTIEYMDLEAK 271
Query: 207 QTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRK 265
Q A + + S + +C + SHG + + I+ D + +++ ++ F+
Sbjct: 272 QIFAKVNEYSKKDHSNMDCFVCFILSHGEKGK------IKGVDNELVNIKDLLSCFSGSN 325
Query: 266 LPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXE 325
P+ PK+F QAC+ G PA V D
Sbjct: 326 CPSLAGKPKLFFIQACQ---------GSVGHPAVTVKED-------CSGHLETDAIPALS 369
Query: 326 KPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCE 360
P +++L+ +T+ F +R ++ GS YIQ LC+
Sbjct: 370 IPDQADVLVGMATVEDFECYRSIETGSVYIQCLCD 404
>UniRef50_Q7QKT2 Cluster: ENSANGP00000015505; n=3; Anopheles gambiae
str. PEST|Rep: ENSANGP00000015505 - Anopheles gambiae
str. PEST
Length = 263
Score = 56.4 bits (130), Expect = 1e-06
Identities = 51/221 (23%), Positives = 92/221 (41%), Gaps = 25/221 (11%)
Query: 166 ISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYEC 224
I+ ++N +R G D L+ + S + F+V + T + R L+++S +C
Sbjct: 36 IAVVINNNRDRKGSEKDVKALQAVLSHLQFDVRLLSDKTTVEIRHALKEVSKEDHTNNDC 95
Query: 225 VFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGE 284
+ ++ +HG+ R D D ++ + + F K P+ PK+ Q+CRG
Sbjct: 96 LAIIAMAHGYNDRIKFDDD-------YLHIDELWTNFVGNKCPSLIGKPKLVFIQSCRGG 148
Query: 285 NEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFIS 344
D+ G ++A A AR G + P+Y+++L+ S+ S
Sbjct: 149 KLDY---GASIATAD--ARPG------------LEEPVDVKIPMYADLLVMYSSFEHHSS 191
Query: 345 HRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLR 385
R GSW+IQ C+V + L V + +R
Sbjct: 192 IRCRNEGSWFIQSFCQVLGANIAKTELQALLCHVSYLVSIR 232
>UniRef50_Q9I9L7 Cluster: Caspase; n=2; Danio rerio|Rep: Caspase -
Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 383
Score = 55.2 bits (127), Expect = 3e-06
Identities = 58/240 (24%), Positives = 94/240 (39%), Gaps = 25/240 (10%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLAGY--ECVFLVVSSHG 233
R G D + ++ L E+ ++V+ NL+ ++ + + + F+V+ SHG
Sbjct: 162 RSGSEKDEENMEKLLKELDYQVVKRPNLSAKEMDEAIRDFAQREEHKYSDSAFVVIMSHG 221
Query: 234 HERRYSSDTDIRCSD-GKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGG 292
R ++ + + N+ P D PKV + QACRG V
Sbjct: 222 KRDAIMGVHYHRTNNPSDSFPVDNVYRRLNSENCPALRDKPKVILIQACRGGEHGRVWAS 281
Query: 293 GALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGS 352
P D EK S + S P S+R V+ G+
Sbjct: 282 DGEPDEPIEIEDD--------------DFVHKEKDFISLM----SCTPDTKSYRHVQNGT 323
Query: 353 WYIQVLCEVFAERAHDCHVDELFTLVDKRLR----LRFGRQTSSVDRWGFNNKLYLHPGL 408
+Y+Q L +VF + AH+ H++ELF V +R + +Q + DR YL PGL
Sbjct: 324 FYVQTLVDVFIKCAHEDHIEELFRKVLRRFEHPNMIGNFKQMACKDRATLPKLFYLFPGL 383
>UniRef50_A5JSK5 Cluster: Cysteine protease; n=2; Eukaryota|Rep:
Cysteine protease - Oryzias latipes (Medaka fish)
(Japanese ricefish)
Length = 319
Score = 54.4 bits (125), Expect = 5e-06
Identities = 47/220 (21%), Positives = 93/220 (42%), Gaps = 8/220 (3%)
Query: 148 QLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQ 207
++Y+ +R G+ V+ + +FL R G D + L +FS +GF VL ++ T +Q
Sbjct: 56 EVYQLNTRPVGICVIINNQNFLDGSV--RRGTEKDAESLAEVFSWLGFRVLMCKDQTSDQ 113
Query: 208 TRATLEQMSSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLP 267
+ TLE + S+L+ + + + E RY+ F+ I+ + +
Sbjct: 114 MKGTLECL-SLLSSSTDLLKLQAQEWSESRYAGPQQALQHGDAFVC--CILSHGQKGMVL 170
Query: 268 NFTDLPKVF--IFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXE 325
+P I + + + + G + Q + G +
Sbjct: 171 GIDQMPVPIKHITRIFKASEQSALTGKPKMF-LIQACQGGQIHKGVALTDVEADDCSTQT 229
Query: 326 KPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAER 365
P ++IL+A +T+ + ++R + GSW++Q LC+ ER
Sbjct: 230 IPEEADILVALATVEDYPAYRHISEGSWFVQSLCQQLKER 269
>UniRef50_P29466-4 Cluster: Isoform Delta of P29466 ; n=2;
Euarchontoglires|Rep: Isoform Delta of P29466 - Homo
sapiens (Human)
Length = 263
Score = 53.6 bits (123), Expect = 9e-06
Identities = 37/115 (32%), Positives = 49/115 (42%), Gaps = 5/115 (4%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R G VD + L +G+ V +NLT LE + + FLV S
Sbjct: 84 PRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMS 143
Query: 232 HG-HERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGEN 285
HG E + D + L AI + N + P+ D PKV I QACRG+N
Sbjct: 144 HGIREGICGKKHSEQVPD--ILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDN 196
>UniRef50_Q5BLH4 Cluster: Caspase c; n=4; Danio rerio|Rep: Caspase c
- Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 400
Score = 53.2 bits (122), Expect = 1e-05
Identities = 38/127 (29%), Positives = 63/127 (49%), Gaps = 7/127 (5%)
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSSH 232
+R G D ++ L +G+ V+T ++LT + + + A + F+V+ SH
Sbjct: 244 DRKGAERDELSMEMLLKGLGYTVVTLRDLTAQGMLVAMRDFAQREEHAHSDSCFVVLMSH 303
Query: 233 GHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPN---FTDLPKVFIFQACRGENEDFV 289
G+ R + + + SDG+ L+ I + FN PN D PK+ + QACRG+NE V
Sbjct: 304 GNARGIAGVSK-QASDGED-DLFCIDEIFNCLNTPNCDGLRDKPKIILIQACRGDNEGSV 361
Query: 290 QGGGALA 296
+LA
Sbjct: 362 DVTDSLA 368
>UniRef50_UPI0001554FA5 Cluster: PREDICTED: similar to initiator
caspase, partial; n=1; Ornithorhynchus anatinus|Rep:
PREDICTED: similar to initiator caspase, partial -
Ornithorhynchus anatinus
Length = 480
Score = 52.8 bits (121), Expect = 2e-05
Identities = 58/223 (26%), Positives = 90/223 (40%), Gaps = 27/223 (12%)
Query: 150 YRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTR 209
Y+ G V+ + F N + R G + D L +FS + F+V + NL E
Sbjct: 229 YKMNHLPHGFCVIINNSEFQ-NPQNTRRGADKDAAALDKVFSWLQFKVEHHNNLKGEAIS 287
Query: 210 ATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPN 268
L S +C + SHG + +I +D + + L A++ F +
Sbjct: 288 RVLRAYSERDHTDQDCFICCLLSHGQKG------EILGTDWEPVPLRALLGLFTSSACRT 341
Query: 269 FTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPL 328
PK+F QAC+G QG G L+ R+GA+ P
Sbjct: 342 LATKPKIFFVQACQGG-----QGQGGLSLR---GREGALLEADAVVIPSV--------PD 385
Query: 329 YSNILIANSTLPGFISHRDVKAGSWYIQVLC---EVFAERAHD 368
++++L+ +T+ FI R + GS YIQ LC E F R D
Sbjct: 386 WADLLVGMATVEDFICFRRPRHGSEYIQALCRALETFCPRGKD 428
>UniRef50_Q16FR8 Cluster: Caspase-1; n=1; Aedes aegypti|Rep:
Caspase-1 - Aedes aegypti (Yellowfever mosquito)
Length = 283
Score = 52.0 bits (119), Expect = 3e-05
Identities = 54/242 (22%), Positives = 103/242 (42%), Gaps = 25/242 (10%)
Query: 161 VVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGF---EVLTYQNLTL-EQTRATLE-QM 215
V + ++F R G + D ++L ++ +GF ++ Y++ + E RA ++ ++
Sbjct: 39 VAWDKVTFEDTSYDERCGTHKDVERLFHVLPRLGFLKEDIHVYEDYSYGEIQRAAMKLEL 98
Query: 216 SSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKV 275
L +C+ + + +HG ++D + +D +LY +++F L + PK+
Sbjct: 99 DEELHQADCLMVFILTHGE----ANDKLMAQNDS--YNLYEFLEHFTPTALKSMAGKPKL 152
Query: 276 FIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIA 335
FI QACRG D G A + D A P ++++L+
Sbjct: 153 FIVQACRGRKLD----RGVQLRAKLIQADCAKDVVDSQSVVYTY-------PEFADLLLV 201
Query: 336 NSTLPGFISHRDVKAGSWYIQVLCEVFAE--RAHDCHVDELFTLVDKRLRLRFGRQTSSV 393
S+ G S R+ + GSW IQ C V E + +L T ++ + +R
Sbjct: 202 MSSHHGHYSFRN-ETGSWLIQEFCNVIEECDELATTSIYDLLTETNRAVSMRISNADGDK 260
Query: 394 DR 395
D+
Sbjct: 261 DK 262
>UniRef50_Q0Z855 Cluster: Caspase-2; n=1; Haemaphysalis
longicornis|Rep: Caspase-2 - Haemaphysalis longicornis
(Bush tick)
Length = 340
Score = 52.0 bits (119), Expect = 3e-05
Identities = 36/139 (25%), Positives = 63/139 (45%), Gaps = 9/139 (6%)
Query: 148 QLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQ 207
++Y RG ++ + F + R+G +D D++ LF ++ F V NL+ ++
Sbjct: 15 EIYSMTRNPRGSCIIVNNADFHDHSLRCREGSQLDVDRMAGLFRQLHFNVSIASNLSAKE 74
Query: 208 TRATLE--QMSSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISL-YAIVDYFNNR 264
T+ L Q + EC+ +++ SHG D + SDG+ + L + F+N
Sbjct: 75 TKDLLRGFQKAETQKDAECLAVILMSHG------EDGVLYGSDGEKLHLDRDVYQLFDNE 128
Query: 265 KLPNFTDLPKVFIFQACRG 283
PN PK+F RG
Sbjct: 129 NCPNLRGKPKLFFIPGSRG 147
Score = 50.0 bits (114), Expect = 1e-04
Identities = 27/82 (32%), Positives = 46/82 (56%), Gaps = 4/82 (4%)
Query: 330 SNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRF--- 386
S++ IA +T PG++S ++ GSW++ + EVF++ A +D L V + + R
Sbjct: 217 SDMYIAYATRPGYVSLKNEIIGSWFLSAVSEVFSQHACTLSLDGLMRRVSQNVMDRSAHD 276
Query: 387 -GRQTSSVDRWGFNNKLYLHPG 407
+QT SV G+ +LY +PG
Sbjct: 277 GSKQTPSVTTIGWRKELYFNPG 298
>UniRef50_Q4S1R8 Cluster: Chromosome undetermined SCAF14764, whole
genome shotgun sequence; n=2; Tetraodontidae|Rep:
Chromosome undetermined SCAF14764, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 279
Score = 51.6 bits (118), Expect = 4e-05
Identities = 64/243 (26%), Positives = 102/243 (41%), Gaps = 27/243 (11%)
Query: 153 RSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATL 212
R +R V+V + ++ R G + D +L ++GF+V +Q+L+ +
Sbjct: 12 RQGRRAVIVSVGEFYPQVGLQ-RRPGASRDAKRLHKTLMKMGFKVDIHQDLSSGEIYELF 70
Query: 213 EQMSSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDL 272
EQ S +C V+SSHG E + DG+ + L I YF+N+ + T
Sbjct: 71 EQESRRPVE-DCFLAVLSSHGEEGC------VYGWDGEPVQLSHIFAYFDNKCMEKKT-- 121
Query: 273 PKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNI 332
KVF+ QACRG+ D A A A A V PL + +
Sbjct: 122 -KVFLIQACRGDALDDGVEVDAAADADADASAACVFQQCLSV------------PLDTVV 168
Query: 333 LIANSTLPGFISHRDVKAGSWYIQVLCEVFAERA-HDCHVDELFTLVDKRLRLRFGRQTS 391
+ A T PG+ + + AGS + + C++ E D + L T V RL F +
Sbjct: 169 MYA--TAPGYAAFMNA-AGSPFFKAFCDLLLEDGQRDLELTRLLTRVSHRLAYTFQARGP 225
Query: 392 SVD 394
++D
Sbjct: 226 ALD 228
>UniRef50_Q5JRU9 Cluster: Caspase 9, apoptosis-related cysteine
peptidase; n=3; Homo sapiens|Rep: Caspase 9,
apoptosis-related cysteine peptidase - Homo sapiens
(Human)
Length = 266
Score = 51.6 bits (118), Expect = 4e-05
Identities = 22/52 (42%), Positives = 33/52 (63%)
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLV 378
P S+I ++ ST PGF+S RD K+GSWY++ L ++F + AH + L V
Sbjct: 186 PTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRV 237
Score = 36.3 bits (80), Expect = 1.5
Identities = 24/81 (29%), Positives = 40/81 (49%), Gaps = 1/81 (1%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEP-YRDTSITPRERKRILYR 59
M E ++ ++R LVE +D + AL + +F MIE R S + R++ R L
Sbjct: 1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
Query: 60 EITRRGPQAFTMLLEALREMG 80
++ RG QA + + L + G
Sbjct: 61 DLETRGSQALPLFISCLEDTG 81
>UniRef50_A4VB10 Cluster: Putative uncharacterized protein; n=1;
Platynereis dumerilii|Rep: Putative uncharacterized
protein - Platynereis dumerilii (Dumeril's clam worm)
Length = 158
Score = 50.8 bits (116), Expect = 6e-05
Identities = 26/86 (30%), Positives = 47/86 (54%), Gaps = 1/86 (1%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M+ +HKK +Q+N L DLDS+ L+E + + + +E ++T ++K +
Sbjct: 19 MEAKHKKILQKNHELLSNDLDLDSVKRFLFENEILTGEDLEKLALPTMTETQKKEYFLTQ 78
Query: 61 I-TRRGPQAFTMLLEALREMGHWDLV 85
I +RGP A+ +EAL++ H D +
Sbjct: 79 ILPKRGPGAYGKFIEALQQDSHDDYI 104
>UniRef50_UPI0000F2097E Cluster: PREDICTED: hypothetical protein;
n=3; Danio rerio|Rep: PREDICTED: hypothetical protein -
Danio rerio
Length = 266
Score = 50.0 bits (114), Expect = 1e-04
Identities = 35/113 (30%), Positives = 48/113 (42%), Gaps = 7/113 (6%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGH 234
R G +VD +L F +GF V NL+ Q L +S C V+ SHG
Sbjct: 46 RKGNSVDERRLSSTFKSLGFHVKVENNLSANQMIDALRTVSEEDHTDNSCFVCVLMSHGE 105
Query: 235 ERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENED 287
E I SD ++I + + + P+ D PK+F QACRG D
Sbjct: 106 EGT------ILGSDERWIPVKTLTSLLTSDLCPSLRDKPKIFFLQACRGVEYD 152
>UniRef50_UPI0000E48C15 Cluster: PREDICTED: similar to caspase 8;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
similar to caspase 8 - Strongylocentrotus purpuratus
Length = 300
Score = 49.6 bits (113), Expect = 1e-04
Identities = 46/196 (23%), Positives = 88/196 (44%), Gaps = 33/196 (16%)
Query: 169 LLNIEPNRDGVNVDCDK--LKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECV 225
+L + P R V ++ L + + F+ ++ T A+L+Q++++ ++C
Sbjct: 78 VLTVGPERPKEAVQNNEALLNTFHNNLKFKTYVKKDPTARDYVASLQQIANMDHTKFDCF 137
Query: 226 FLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGEN 285
V+ SHG + +DGK +S+ A+ F +P+ + PK+F QAC+G +
Sbjct: 138 VCVILSHGCRG------SVYGTDGKKVSIDALTGLFRGDYVPSLVNKPKLFFIQACQGND 191
Query: 286 EDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISH 345
QG A + +D P S+ L++++T+PG+ S
Sbjct: 192 ---AQG------AVDIQQDATATATL---------------PHNSDTLVSHATIPGYASF 227
Query: 346 RDVKAGSWYIQVLCEV 361
R+ +GS +I LC +
Sbjct: 228 RNAYSGSLFIISLCNI 243
>UniRef50_A6NFM5 Cluster: Uncharacterized protein ENSP00000371619;
n=11; Eutheria|Rep: Uncharacterized protein
ENSP00000371619 - Homo sapiens (Human)
Length = 408
Score = 49.6 bits (113), Expect = 1e-04
Identities = 60/229 (26%), Positives = 94/229 (41%), Gaps = 24/229 (10%)
Query: 167 SFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATL----EQMSSVLAGY 222
+ LL + R G D + L L +GFE + T + + L EQ+ +
Sbjct: 159 ALLLAVIQGRPGAQHDVEALGGLCWALGFETTVRTDPTAQAFQEELAQFREQLDTCRGPV 218
Query: 223 ECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACR 282
C + + +HG R + +DG+ + A++ + ++ PK+F+ QACR
Sbjct: 219 SCALVALMAHGGPRG-----QLLGADGQEVQPEALMQELSRCQV--LQGRPKIFLLQACR 271
Query: 283 GENEDFVQGGGAL--------APAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILI 334
G N D G AL AP P V V ++IL
Sbjct: 272 GGNRDAGVGPTALPWYWSWLRAP-PSVPSHADVLQIYAEAQGSSCRGTPPGSSDQADILT 330
Query: 335 ANSTLPGFISHRDVKAGSWYIQVLCEVF-AERAHDCHVDELFTLVDKRL 382
S G++++RD K GS +IQ L EV A D + EL T V++R+
Sbjct: 331 VYSAAEGYVAYRDDK-GSDFIQTLVEVLRANPGRD--LLELLTEVNRRV 376
>UniRef50_P55213 Cluster: Caspase-3 precursor (EC 3.4.22.56)
(CASP-3) (Apopain) (Cysteine protease CPP32) (Yama
protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1)
(LICE) (IRP) [Contains: Caspase-3 subunit p17; Caspase-3
subunit p12]; n=32; Euteleostomi|Rep: Caspase-3
precursor (EC 3.4.22.56) (CASP-3) (Apopain) (Cysteine
protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage
activity 1) (SCA-1) (LICE) (IRP) [Contains: Caspase-3
subunit p17; Caspase-3 subunit p12] - Rattus norvegicus
(Rat)
Length = 277
Score = 49.2 bits (112), Expect = 2e-04
Identities = 50/212 (23%), Positives = 84/212 (39%), Gaps = 29/212 (13%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLAGYECVFL-VVSSHGH 234
R+G +VD L+ F + +EV +LT E+ ++ +S F+ V+ SHG
Sbjct: 64 RNGTDVDAANLRETFMALKYEVRNKNDLTREEIMELMDSVSKEDHSKRSSFVCVILSHGD 123
Query: 235 ERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGA 294
E I ++G + L + +F + T PK+FI
Sbjct: 124 EGV------IFGTNGP-VDLKKLTSFFRGDYCRSLTGKPKLFII---------------- 160
Query: 295 LAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWY 354
Q R + + P+ ++ L A ST PG+ S R+ + GSW+
Sbjct: 161 -----QACRGTELDCGIETDSGTDDDMACQKIPVEADFLYAYSTAPGYYSWRNSRDGSWF 215
Query: 355 IQVLCEVFAERAHDCHVDELFTLVDKRLRLRF 386
IQ LC + AH + T V++++ F
Sbjct: 216 IQSLCAMLKLYAHKLEFMHILTRVNRKVATEF 247
>UniRef50_Q2TM51 Cluster: Caspase; n=3; Penaeidae|Rep: Caspase -
Fenneropenaeus merguiensis (Banana prawn) (Penaeus
merguiensis)
Length = 320
Score = 48.8 bits (111), Expect = 3e-04
Identities = 33/139 (23%), Positives = 61/139 (43%), Gaps = 2/139 (1%)
Query: 150 YRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTR 209
Y +R RG ++F++ F R D + F +GF + NLT ++
Sbjct: 61 YPMNNRPRGAALIFAHSEFKNESLRPRPSAAHDAEIASDAFKALGFLPEVFSNLTKDELE 120
Query: 210 ATLEQMSS-VLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPN 268
TL ++S +G + + +V SHG + ++ + D K + ++ F + +
Sbjct: 121 KTLHEVSKRDHSGSDALVIVFMSHGEVKPRNNMEFVWAKDDKIPTKELWIN-FTAERCAS 179
Query: 269 FTDLPKVFIFQACRGENED 287
PK++ QACRG + D
Sbjct: 180 LAGKPKLYFIQACRGLDVD 198
>UniRef50_Q9IB64 Cluster: Caspase-8; n=1; Xenopus laevis|Rep:
Caspase-8 - Xenopus laevis (African clawed frog)
Length = 500
Score = 48.4 bits (110), Expect = 3e-04
Identities = 48/201 (23%), Positives = 83/201 (41%), Gaps = 25/201 (12%)
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLAGYECVFLV-VSSHG 233
+R+G D +++ +F+ G+ +++LT + TLE S + F+ + SHG
Sbjct: 283 DREGTAKDAEEITRIFNARGYITEEHRDLTAANIQKTLEMYSKKDHAEKDSFVCFILSHG 342
Query: 234 HERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGG 293
T C DG+ + + + YFN + + + PK+F QAC+G+
Sbjct: 343 -----GVGTVCGC-DGEEVEIKRLTKYFNGQHCRSLINKPKIFFIQACQGKESH------ 390
Query: 294 ALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSW 353
P+V D PL ++ L A +T+ + S R + GS
Sbjct: 391 -----PKVDMD-------MDTSFYEPDANGSHLPLEADFLTAFATVEDYTSLRHRENGSI 438
Query: 354 YIQVLCEVFAERAHDCHVDEL 374
YIQ LC+ + +D L
Sbjct: 439 YIQQLCKALTTYTNQDLIDIL 459
>UniRef50_Q8I749 Cluster: Caspase-related protein; n=1; Suberites
domuncula|Rep: Caspase-related protein - Suberites
domuncula (Sponge)
Length = 496
Score = 48.4 bits (110), Expect = 3e-04
Identities = 42/209 (20%), Positives = 80/209 (38%), Gaps = 19/209 (9%)
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTL-EQTRATLEQMSSVLAGYECVFLVVSSHG 233
NR G ++D L F + ++V +N++ E + L + S Y+ ++ + G
Sbjct: 275 NRGGAHIDVHNLTQTFKYLRYKVEVVENISSSEMNKVMLRKASEDHPQYDSFVCIIMTQG 334
Query: 234 HERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGG 293
+ +D + ++LY + + P PK+F QACRG+ ++ G
Sbjct: 335 ------GSNIVHGADSEAVNLYDLTGVM--KMCPTLRGKPKIFFVQACRGD----IESMG 382
Query: 294 ALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSW 353
D P ++ +T G+ ++R + GSW
Sbjct: 383 FKNEEVSKTEDDLQADMPGGHLHTDTI------PQEADFFYGFATPLGYAAYRSRRHGSW 436
Query: 354 YIQVLCEVFAERAHDCHVDELFTLVDKRL 382
YI LC+VF + + + V+ R+
Sbjct: 437 YISELCQVFIKHPFTHSLGSMMKKVNNRV 465
>UniRef50_O08736 Cluster: Caspase-12 precursor; n=12; Eutheria|Rep:
Caspase-12 precursor - Mus musculus (Mouse)
Length = 419
Score = 48.4 bits (110), Expect = 3e-04
Identities = 52/236 (22%), Positives = 88/236 (37%), Gaps = 11/236 (4%)
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSSH 232
+RD + D ++ L +G+ V+ +NLT ++ L Q + + FLV SH
Sbjct: 191 DRDNADTDILNMQELLENLGYSVVLKENLTAQEMETELMQFAGRPEHQSSDSTFLVFMSH 250
Query: 233 GHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGG 292
G R + I FNN + + PK+ I QACRG G
Sbjct: 251 GILEGICG-VKHRNKKPDVLHDDTIFKIFNNSNCRSLRNKPKILIMQACRGR----YNGT 305
Query: 293 GALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGS 352
++ +A + + ++ + S+ P IS + K GS
Sbjct: 306 IWVSTNKGIA---TADTDEERVLSCKWNNSITKAHVETDFIAFKSSTPHNISWKVGKTGS 362
Query: 353 WYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFG-RQTSSVDRWGFNNKLYLHPG 407
+I L + F + H++E+F V + Q +++R YL PG
Sbjct: 363 LFISKLIDCFKKYCWCYHLEEIFRKVQHSFEVPGELTQMPTIERVSMTRYFYLFPG 418
>UniRef50_UPI00006A1E20 Cluster: Caspase-9 precursor (EC 3.4.22.62)
(CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6)
(Apoptotic protease Mch-6) (Apoptotic protease-
activating factor 3) (APAF-3) [Contains: Caspase-9
subunit p35; Caspase-9 subunit p10].; n=1; Xenopus
tropicalis|Rep: Caspase-9 precursor (EC 3.4.22.62)
(CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6)
(Apoptotic protease Mch-6) (Apoptotic protease-
activating factor 3) (APAF-3) [Contains: Caspase-9
subunit p35; Caspase-9 subunit p10]. - Xenopus
tropicalis
Length = 141
Score = 47.6 bits (108), Expect = 6e-04
Identities = 24/62 (38%), Positives = 33/62 (53%), Gaps = 1/62 (1%)
Query: 223 ECVFLVVSSHGHERRYSS-DTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQAC 281
+C +V+ SHG E R+ + +DG I + IV YFN K P+ PK+F QAC
Sbjct: 13 DCCLVVILSHGCETRHIQFPGGVYGTDGIRIPVERIVSYFNGSKCPSLRGKPKIFFIQAC 72
Query: 282 RG 283
G
Sbjct: 73 GG 74
Score = 36.7 bits (81), Expect = 1.1
Identities = 16/38 (42%), Positives = 22/38 (57%)
Query: 341 GFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLV 378
G++S RD GSWY++VL V AE A + L +V
Sbjct: 75 GYVSWRDKHTGSWYVEVLDNVLAEHAATDDLQSLLVMV 112
>UniRef50_Q9I8J3 Cluster: Caspase-8; n=11; Danio rerio|Rep:
Caspase-8 - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 476
Score = 47.6 bits (108), Expect = 6e-04
Identities = 50/220 (22%), Positives = 92/220 (41%), Gaps = 20/220 (9%)
Query: 148 QLYRTRSRKRGVLVVFSYISFLLNIEP-NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLE 206
+ Y R G ++ + +FL + R G ++D D+L LFS + F++ +L
Sbjct: 228 EYYILTQRPLGYCLIINNYNFLESTNLLKRTGTDMDKDRLAKLFSRMHFQIEVRNDLEAW 287
Query: 207 QTRATLEQMSS-VLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRK 265
+ ++Q ++ A + SHG + + +DGK + + + F +
Sbjct: 288 AIKDEIKQFANRNHASMGAFVCCILSHGEK------GTVLGTDGKPVEIREVTLPFAGCR 341
Query: 266 LPNFTDLPKVFIFQACRG-ENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXX 324
PK+F QAC+G EN+ V AP+ +
Sbjct: 342 --TLASKPKLFFIQACQGDENQAGVWTSDGREDAPEEDEE---------YEEDAGIIVLR 390
Query: 325 EKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAE 364
+ P+ ++ LI +T+ ++S+R K GS +IQ LC+ E
Sbjct: 391 KIPIEADFLIGMATVEHYLSYRHTKKGSIFIQELCKKMEE 430
>UniRef50_Q69HP8 Cluster: Caspase-1-like; n=1; Ciona
intestinalis|Rep: Caspase-1-like - Ciona intestinalis
(Transparent sea squirt)
Length = 254
Score = 47.6 bits (108), Expect = 6e-04
Identities = 36/144 (25%), Positives = 64/144 (44%), Gaps = 8/144 (5%)
Query: 142 DVSRDIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQ 201
DV D Y KRG+ ++F +F ++ R G +D L+ ++GF
Sbjct: 49 DVKFDYFEYNMSFPKRGIFLIFDQENFDYGLQ-QRVGSKLDRIVLEETAIKLGFTPNVCH 107
Query: 202 NLTLEQTRATLEQMSSVL-AGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDY 260
+ T + A L ++S + + Y+C + +HG E D + D + L ++
Sbjct: 108 DYTKDDVYAELRKISQMNHSQYDCFACAILTHGEE-----DEMVYAKDDS-MKLKTLISR 161
Query: 261 FNNRKLPNFTDLPKVFIFQACRGE 284
+ + P+ PK+F QACRG+
Sbjct: 162 VSATECPSLAGKPKLFFVQACRGK 185
>UniRef50_UPI0000E4A029 Cluster: PREDICTED: similar to PDZ domain
containing protein NHERF-2; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to PDZ domain
containing protein NHERF-2 - Strongylocentrotus
purpuratus
Length = 792
Score = 46.8 bits (106), Expect = 0.001
Identities = 20/47 (42%), Positives = 29/47 (61%)
Query: 341 GFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFG 387
G+ S R + GSW+IQ LCE AHD H+D++ T V R++ + G
Sbjct: 342 GYFSLRHKQNGSWFIQALCEELIASAHDHHLDDIMTKVTDRVKRQEG 388
Score = 34.3 bits (75), Expect = 5.9
Identities = 17/59 (28%), Positives = 31/59 (52%)
Query: 148 QLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLE 206
+ Y R +G++ + + F + R G +VD +K++F+EIG+ QNLT +
Sbjct: 255 ECYPMDQRNKGLVFILNNYRFGPDRTTERTGSDVDLANVKHVFTEIGYTADEAQNLTAQ 313
>UniRef50_UPI0000F2CF2F Cluster: PREDICTED: similar to caspase 12;
n=1; Monodelphis domestica|Rep: PREDICTED: similar to
caspase 12 - Monodelphis domestica
Length = 401
Score = 46.4 bits (105), Expect = 0.001
Identities = 46/230 (20%), Positives = 88/230 (38%), Gaps = 9/230 (3%)
Query: 182 DCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMS--SVLAGYECVFLVVSSHGHERRYS 239
D +++K L +G+ V + L+ + L+Q + + FL+ S+G
Sbjct: 178 DIERMKDLLQILGYRVEVKKELSSVDMESVLKQFALRQEHESSDSTFLIFMSYGTTTGIC 237
Query: 240 SDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAP 299
+ + ++ I FNN + PK+ I Q C+ + GA+A
Sbjct: 238 GIKHKQL-EPDILANDTIFKIFNNSNCSRLRNKPKIIIIQECQEGIRKQLFIHGAMA--- 293
Query: 300 QVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLC 359
A + ++ + + + +S P IS D + GS ++ +L
Sbjct: 294 --ASADSYNQSSSSDTEGFWKDAARKEHVEKDFICFHSITPNDISLEDNQEGSLFVTLLT 351
Query: 360 EVFAERAHDCHVDELFTLVDKRLRLR-FGRQTSSVDRWGFNNKLYLHPGL 408
+ F + + CHV++LF V K +++R YL PG+
Sbjct: 352 DCFQQYSWCCHVEDLFKKVQKSFATSPVPVPMPTIERQSMTRYFYLFPGI 401
>UniRef50_Q8JIS8 Cluster: Caspase 3A; n=3; Euteleostomi|Rep: Caspase
3A - Oryzias latipes (Medaka fish) (Japanese ricefish)
Length = 290
Score = 46.4 bits (105), Expect = 0.001
Identities = 34/112 (30%), Positives = 52/112 (46%), Gaps = 14/112 (12%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMS----SVLAGYECVFLVVSS 231
R+G + D F ++G+E+ Y + T++Q + QMS S A + CV L S
Sbjct: 77 RNGTDNDAAAAWKSFMKLGYEIQMYNDQTVDQMKKLFRQMSNQDHSKFASFACVIL---S 133
Query: 232 HGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRG 283
HG E I +DG +S +++ R + PK+F QACRG
Sbjct: 134 HGEE------GVIYGTDGP-VSFNKLIECLKGRSCLSLVGKPKLFFIQACRG 178
Score = 45.2 bits (102), Expect = 0.003
Identities = 25/75 (33%), Positives = 41/75 (54%), Gaps = 3/75 (4%)
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRF 386
PL ++ L A ST+ G+ S R GSW+IQ LCE+ + + + ++ T V+ ++ F
Sbjct: 198 PLEADFLFAYSTVSGYYSWRSTANGSWFIQSLCEMLEKFSKTLDLMQIMTRVNHKVATHF 257
Query: 387 GRQTSSVDRWGFNNK 401
SS + GF+ K
Sbjct: 258 ---ESSSNAPGFSGK 269
>UniRef50_Q2HZ04 Cluster: ICE-5; n=3; Bombyx mori|Rep: ICE-5 -
Bombyx mori (Silk moth)
Length = 312
Score = 46.4 bits (105), Expect = 0.001
Identities = 50/217 (23%), Positives = 83/217 (38%), Gaps = 22/217 (10%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQT-RATLEQMSSVLAGYECVFLVVSSHGH 234
R+G D LK LF + + V TY +L E E + CV + + +HG
Sbjct: 73 RNGTFEDVKSLKDLFEGLSYNVTTYTDLIYEDILNRVAEFCQRDHSKTSCVIVTILTHGD 132
Query: 235 ERR-YSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGG 293
+++D + SD + + N PK+F QACRG D +G
Sbjct: 133 SGEVFAADQPYKISD--------LTNMIENAH-HTLVGKPKIFFIQACRGPFMD--EGRT 181
Query: 294 ALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNI----LIANSTLP----GFISH 345
+ + P+ S I + + P G++S+
Sbjct: 182 VVLDGESRSVLRLPTHSDFLFLHSSVDELVTRVPVLSTISRLFAVFSFKKPRKRRGYLSY 241
Query: 346 RDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRL 382
RD + GSW IQ LCE+ + + + + T+V+K +
Sbjct: 242 RDSR-GSWLIQTLCEIIRKNHKEIDLLHMITMVNKSI 277
>UniRef50_UPI0000E4699D Cluster: PREDICTED: similar to caspase 2;
n=3; Strongylocentrotus purpuratus|Rep: PREDICTED:
similar to caspase 2 - Strongylocentrotus purpuratus
Length = 153
Score = 46.0 bits (104), Expect = 0.002
Identities = 32/117 (27%), Positives = 56/117 (47%), Gaps = 7/117 (5%)
Query: 166 ISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLAGYECV 225
+ FL N+ +R G +VD ++++F+EIG+E+ T+ +LT E + LE + + +
Sbjct: 8 LMFLFNMSKDRKGSDVDVRNIQHVFTEIGYEIETHSDLTAEDLQDKLETFAGYVRHHYMP 67
Query: 226 FLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACR 282
V G+ S T I C+D Y ++ +R + PK+ FQ R
Sbjct: 68 SAVFVIMGN----GSSTGIHCTDEPV--TYKFIENKVSR-MKYMKGKPKMIFFQGNR 117
>UniRef50_UPI000065FEF6 Cluster: Homolog of Ictalurus punctatus
"Caspase 8.; n=1; Takifugu rubripes|Rep: Homolog of
Ictalurus punctatus "Caspase 8. - Takifugu rubripes
Length = 340
Score = 44.8 bits (101), Expect = 0.004
Identities = 52/212 (24%), Positives = 87/212 (41%), Gaps = 31/212 (14%)
Query: 154 SRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQT-RATL 212
S+ G+ V+ + +FL R G N D L +F+ +GF VL ++ T E+ RA +
Sbjct: 112 SQPTGLCVIINNENFL--DMKQRSGTNKDAQSLAEVFTWLGFRVLMCKDQTKEKMDRAFV 169
Query: 213 EQMSSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDL 272
+ G + + SHG + + + DG+ + + I+ F +
Sbjct: 170 DLQVDPKHG-DAFICCILSHGEK------SAVLGIDGEPLCIKQIIRTFKATRQSALVSK 222
Query: 273 PKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNI 332
PK+F+ QAC QG G G + P ++I
Sbjct: 223 PKMFLIQAC--------QGKGT--------HRGVLLKDLQTDDCHTLSI-----PEEADI 261
Query: 333 LIANSTLPGFISHRDVKAGSWYIQVLCEVFAE 364
L+A +T+ ++S R GSW+IQ LC+ E
Sbjct: 262 LVATATVEDYVSFRHKIDGSWFIQSLCQELKE 293
>UniRef50_A7SYJ3 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 263
Score = 44.8 bits (101), Expect = 0.004
Identities = 26/89 (29%), Positives = 48/89 (53%), Gaps = 4/89 (4%)
Query: 325 EKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRL-- 382
+ P+ +++ A ST+ G+ S R+ + GSW+I + +VF++ A + + L T V +
Sbjct: 173 DAPVLQDVIFAYSTVEGYASFRNTQ-GSWFINAIVDVFSKHAWEEDIVSLLTYVSYEVSR 231
Query: 383 RLRF-GRQTSSVDRWGFNNKLYLHPGLYE 410
+L F G + + KL+L PG +E
Sbjct: 232 KLSFQGYKQIPAPQSTLTKKLFLLPGYFE 260
>UniRef50_Q28GK9 Cluster: Novel protein; n=1; Xenopus
tropicalis|Rep: Novel protein - Xenopus tropicalis
(Western clawed frog) (Silurana tropicalis)
Length = 239
Score = 44.4 bits (100), Expect = 0.006
Identities = 31/112 (27%), Positives = 54/112 (48%), Gaps = 7/112 (6%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLAGYECVFLVVSSHGHE 235
R GV D ++L + S +G++V + +++ ++ + ++ S + G E ++SSHG+E
Sbjct: 26 RKGVKRDVNRLFKVLSRLGYKVSLHMDVSAKEIKDIYQKESKMPQG-ESFISILSSHGNE 84
Query: 236 RRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENED 287
I G + L + D P +PK+F QACRGE D
Sbjct: 85 GL------IYDFYGTPVLLRDLYDILAPNNSPLLAGVPKLFFVQACRGEQFD 130
>UniRef50_UPI0000F1EFFE Cluster: PREDICTED: hypothetical protein;
n=4; Danio rerio|Rep: PREDICTED: hypothetical protein -
Danio rerio
Length = 277
Score = 44.0 bits (99), Expect = 0.007
Identities = 35/112 (31%), Positives = 51/112 (45%), Gaps = 10/112 (8%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLAGYECVFLVVSSHGHE 235
R GV D +L + SE+GF V ++ E+ + S EC ++SSHG E
Sbjct: 51 RIGVKRDSRRLYKILSELGFSVDIRLDIEAEEIYQAFKAESEQTVK-ECFVGIISSHGEE 109
Query: 236 RRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENED 287
C DG+ ++L I F + P D K+F+ QACRG + D
Sbjct: 110 -----GVVFGC-DGRAVNLAEIYSCFRS---PIMKDKSKLFLIQACRGGDLD 152
>UniRef50_Q7QGN0 Cluster: ENSANGP00000018113; n=4; Anopheles gambiae
str. PEST|Rep: ENSANGP00000018113 - Anopheles gambiae
str. PEST
Length = 214
Score = 43.6 bits (98), Expect = 0.010
Identities = 38/128 (29%), Positives = 60/128 (46%), Gaps = 11/128 (8%)
Query: 160 LVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTY-QNLT-LEQTRATLEQMSS 217
++VF + F N + NR+G D ++K + L +N T E TR E
Sbjct: 4 VLVFHHDQFK-NPKNNREGSANDMKQIKEFCQHYRCDRLDINENKTKAEVTRKMGEISRK 62
Query: 218 VLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYA-IVDYFNNRKLPNFTDLPKVF 276
C+ + + SHG S++ I DG+F S +V+Y + + N D PK+F
Sbjct: 63 DFTKNSCLIVFIMSHG-----SANDTIMAKDGQFYSFQDDVVEYCTSNRTLN--DKPKLF 115
Query: 277 IFQACRGE 284
+ QACRG+
Sbjct: 116 VLQACRGD 123
>UniRef50_A1L2P4 Cluster: LOC100036910 protein; n=1; Xenopus
laevis|Rep: LOC100036910 protein - Xenopus laevis
(African clawed frog)
Length = 235
Score = 42.7 bits (96), Expect = 0.017
Identities = 39/143 (27%), Positives = 61/143 (42%), Gaps = 15/143 (10%)
Query: 150 YRTRSRKRGVLVVFSYISFLLNIEPN-RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQT 208
YRT + GV ++ + +F + R+G +VD +L F+ +G++V +
Sbjct: 48 YRTDYPEMGVCLIINNKNFHSSTSMTVRNGTDVDARRLHETFTSLGYKVKVLNDQRCNDI 107
Query: 209 RATLEQMS----SVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNR 264
L++MS S + + C L SHG D I DG I + + D F
Sbjct: 108 FGHLKKMSEEDHSKRSSFACAIL---SHGE------DGLIYGVDGP-IPVKNLTDLFRGD 157
Query: 265 KLPNFTDLPKVFIFQACRGENED 287
+ PK+F QACRG D
Sbjct: 158 RCKTLVGKPKIFFIQACRGTELD 180
>UniRef50_UPI0000E25016 Cluster: PREDICTED: similar to caspase 14
precursor; n=1; Pan troglodytes|Rep: PREDICTED: similar
to caspase 14 precursor - Pan troglodytes
Length = 202
Score = 41.9 bits (94), Expect = 0.029
Identities = 22/56 (39%), Positives = 35/56 (62%), Gaps = 2/56 (3%)
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRL 382
P Y++ L ST+ G+I++R + GS +IQ L +VF +R H+ EL T V +R+
Sbjct: 120 PTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTKRKG--HILELLTEVTRRM 173
>UniRef50_A7M858 Cluster: Caspase-like protease; n=1; Suberites
domuncula|Rep: Caspase-like protease - Suberites
domuncula (Sponge)
Length = 477
Score = 41.1 bits (92), Expect = 0.051
Identities = 46/207 (22%), Positives = 81/207 (39%), Gaps = 11/207 (5%)
Query: 182 DCDKLKYLFSEIGFEVLTYQNLT---LEQTRATLEQMSSVLAGYECVFLVVSSHGHER-- 236
D ++ +F E+ + V N++ L+Q Q S+ Y+ + +V S HG +
Sbjct: 43 DGKRIADVFRELNYAVFHMYNVSEHQLDQLLYEATQKSTYPRCYQSIVVVYSGHGSIQVI 102
Query: 237 -RYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGAL 295
+S T + D + IV F P +PKVF+ AC G+ + + +
Sbjct: 103 NDQNSLTFLYTQDCFQYPIKEIVKCFMPSYSPKIGAMPKVFLIDACLGDKQMYTEA---- 158
Query: 296 APAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYI 355
P+ + V + P N ++A+ST G+ S+ +G +I
Sbjct: 159 VTVPK-SGGAEVRGLAMVSDKGGKEVPTIDVPPEGNYIVAHSTSVGYQSYEIKGSGGVWI 217
Query: 356 QVLCEVFAERAHDCHVDELFTLVDKRL 382
+ L E + D V + T V L
Sbjct: 218 KRLAEKIRFKGRDESVMNILTEVSGEL 244
>UniRef50_UPI0000E82482 Cluster: PREDICTED: hypothetical protein;
n=2; Gallus gallus|Rep: PREDICTED: hypothetical protein
- Gallus gallus
Length = 266
Score = 40.7 bits (91), Expect = 0.068
Identities = 31/114 (27%), Positives = 51/114 (44%), Gaps = 8/114 (7%)
Query: 170 LNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLAGYECVFLVV 229
+ + P R G + +KL + +++ + V N T ++ +Q S G + V+
Sbjct: 24 VGLRPRR-GARREAEKLSRVLAQLSYRVKLLHNRTAKEMEDLYQQECSREHG-DYFVSVI 81
Query: 230 SSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRG 283
SSHG E + C D + + L I + + P + PKVF QACRG
Sbjct: 82 SSHGEEGAV-----LGC-DCRPLRLTRIFHIVSAQNCPALAERPKVFFIQACRG 129
>UniRef50_Q8IRY7 Cluster: Caspase-8 precursor (EC 3.4.22.61)
(Death-related Ced-3/NEDD2-like protein) [Contains:
Caspase-8 subunit p15; Caspase-8 subunit p10]; n=7;
Sophophora|Rep: Caspase-8 precursor (EC 3.4.22.61)
(Death-related Ced-3/NEDD2-like protein) [Contains:
Caspase-8 subunit p15; Caspase-8 subunit p10] -
Drosophila melanogaster (Fruit fly)
Length = 516
Score = 40.3 bits (90), Expect = 0.090
Identities = 18/63 (28%), Positives = 34/63 (53%)
Query: 331 NILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGRQT 390
++L A ST+ G+ + R + GSW+I LC+ R+ H+ ++ T+V + + G
Sbjct: 436 DMLRAMSTVNGYAALRHTQTGSWFIGSLCDAIDRRSASEHIADILTIVTNEVSKKRGSND 495
Query: 391 SSV 393
S+
Sbjct: 496 ESM 498
>UniRef50_UPI0000DB7195 Cluster: PREDICTED: similar to caspase 10
isoform a preproprotein; n=1; Apis mellifera|Rep:
PREDICTED: similar to caspase 10 isoform a preproprotein
- Apis mellifera
Length = 247
Score = 39.9 bits (89), Expect = 0.12
Identities = 38/140 (27%), Positives = 59/140 (42%), Gaps = 28/140 (20%)
Query: 222 YECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQAC 281
Y+C+F+ + SHG+E S +D K + I F + +L D+ K+ I QAC
Sbjct: 78 YDCIFVCILSHGYEGGIIS------ADEKEVKTEEIEYKFCSIELK---DVIKIVIIQAC 128
Query: 282 RGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPG 341
+G+ V+ + DG + Y N I ST+ G
Sbjct: 129 QGKIIGQVEDS--------LVTDGFINCNISKNILS-----------YRNFCIFMSTIQG 169
Query: 342 FISHRDVKAGSWYIQVLCEV 361
F+S R + GSW+IQ C +
Sbjct: 170 FVSMRHKEKGSWFIQEFCNI 189
>UniRef50_Q28XB8 Cluster: GA14832-PA; n=1; Drosophila
pseudoobscura|Rep: GA14832-PA - Drosophila pseudoobscura
(Fruit fly)
Length = 196
Score = 39.9 bits (89), Expect = 0.12
Identities = 32/131 (24%), Positives = 60/131 (45%), Gaps = 11/131 (8%)
Query: 159 VLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV 218
++ +F++ +F ++ R G D L+ F ++ +++ ++ TL + + ++
Sbjct: 3 LIYIFNHETFKNDLHEPRIGSAKDVQALRKTFEKLQCQIIEIKDPTLAAVKEKISEIERK 62
Query: 219 -LAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLY--AIVDYFNNRKLPNFTDLPKV 275
+ +V+ SHG E I SD K SL+ ++ F N L PK+
Sbjct: 63 NFEQQSALIIVLLSHGGENEM-----IVASDNKEYSLHKDVLLPLFKNETLKG---KPKI 114
Query: 276 FIFQACRGENE 286
I QAC+GE E
Sbjct: 115 LIAQACKGELE 125
>UniRef50_UPI0000F2DFE8 Cluster: PREDICTED: similar to initiator
caspase; n=1; Monodelphis domestica|Rep: PREDICTED:
similar to initiator caspase - Monodelphis domestica
Length = 473
Score = 39.1 bits (87), Expect = 0.21
Identities = 30/139 (21%), Positives = 55/139 (39%), Gaps = 8/139 (5%)
Query: 150 YRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTR 209
Y+ G +V+ I F ++ R G D L+ +F + F+ + NL Q
Sbjct: 208 YKMEHVPHGYVVIIDNIHFSNPVDV-RIGTEKDVAALRKVFGRLQFKEKYHSNLDASQLH 266
Query: 210 ATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPN 268
++ S + + SHG + + +D K +++ ++ YF +
Sbjct: 267 EVMKDYSKRDYTDQDAFICCILSHGKKGV------VLGTDWKPVAIKKLLSYFTANECKT 320
Query: 269 FTDLPKVFIFQACRGENED 287
D PK+F QAC+ D
Sbjct: 321 LKDKPKLFFIQACQNGKSD 339
>UniRef50_Q5K5C1 Cluster: Caspase 7-like protein; n=1; Spodoptera
frugiperda ascovirus 1a|Rep: Caspase 7-like protein -
Spodoptera frugiperda ascovirus 1a
Length = 288
Score = 39.1 bits (87), Expect = 0.21
Identities = 39/143 (27%), Positives = 67/143 (46%), Gaps = 16/143 (11%)
Query: 150 YRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDK--LKYLFSEIGFEVLTYQNLTLEQ 207
Y T R++ +L++ L N + DG D D+ L F+++ F+V T +N +
Sbjct: 6 YDTVGREKRLLIINQRALALPNRTISSDGTCCDGDEYLLVDTFTKLNFKVQTIRNASKIV 65
Query: 208 TRATLEQ-MSSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFI--SLYAIVDYFNNR 264
T+ + + C F+VV + G++ +DT I +DG + LYA+ + R
Sbjct: 66 LETTVRNYIEKNVKRVACYFVVVLNDGND----ADT-ILTTDGTYSLSELYALFTLYTVR 120
Query: 265 KLPNFTDLPKVFIFQACRGENED 287
+P KVF+ Q+C G D
Sbjct: 121 AIP------KVFLIQSCLGAKID 137
>UniRef50_Q98IJ6 Cluster: Mll2372 protein; n=1; Mesorhizobium
loti|Rep: Mll2372 protein - Rhizobium loti
(Mesorhizobium loti)
Length = 388
Score = 38.7 bits (86), Expect = 0.27
Identities = 26/104 (25%), Positives = 46/104 (44%), Gaps = 4/104 (3%)
Query: 182 DCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLAGYECVFLVVSSHGHE---RRY 238
D + +GFEV++ +LT +QT+ T+ Q + + G + + HG + + Y
Sbjct: 33 DAQAMAERLQNLGFEVVSGFDLTKQQTQVTVAQFAKQVRGADVALFFYAGHGLQVSGKNY 92
Query: 239 SSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACR 282
D D + A+ F R++ T + VF+ ACR
Sbjct: 93 LLPVDAALEDETSLDFEAVSVDFILRQMSRETSIRLVFL-DACR 135
>UniRef50_A4KXL9 Cluster: Caspase-like protein; n=1; Heliothis
virescens ascovirus 3e|Rep: Caspase-like protein -
Heliothis virescens ascovirus 3e
Length = 314
Score = 37.9 bits (84), Expect = 0.48
Identities = 32/128 (25%), Positives = 60/128 (46%), Gaps = 12/128 (9%)
Query: 159 VLVVFSYISFLLNIEPNRDGV--NVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMS 216
+LVV + L + DG N D +++ FS++GF+ Y+N+T + + ++
Sbjct: 16 ILVVINQRCLALPSMMSADGTCCNGDENRVIDTFSKLGFQDFVYRNMTTADLKDIVTLLT 75
Query: 217 -SVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKV 275
Y CV +V+ + G ++ +I+ +DG Y + D+ + D PK+
Sbjct: 76 RHNHRTYSCVVVVILTDG-----AAVGEIKTADGS----YKLRDFMTLFDVDKLRDKPKM 126
Query: 276 FIFQACRG 283
F+ Q RG
Sbjct: 127 FVVQTNRG 134
>UniRef50_Q1JPW7 Cluster: Cflar protein; n=3; Danio rerio|Rep: Cflar
protein - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 461
Score = 35.9 bits (79), Expect = 1.9
Identities = 29/108 (26%), Positives = 52/108 (48%), Gaps = 12/108 (11%)
Query: 177 DGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMS--SVLAGYECVFLVVSSHGH 234
D V D + LK+ F +GF+V+ + L L++T+ LE +S +L C + S G
Sbjct: 255 DCVGYDGEMLKHTFECLGFKVVFHSLLGLKETQKVLEDLSLNRILQRVRCFVCCLISRG- 313
Query: 235 ERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACR 282
++T + +D + ++ + ++L N T PK+F Q R
Sbjct: 314 -----TNTHLLATDSNRLG----INLKDLKQLFNATKCPKIFFTQLYR 352
>UniRef50_UPI0000587370 Cluster: PREDICTED: similar to caspase 8,
partial; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to caspase 8, partial -
Strongylocentrotus purpuratus
Length = 447
Score = 35.5 bits (78), Expect = 2.6
Identities = 21/92 (22%), Positives = 44/92 (47%), Gaps = 2/92 (2%)
Query: 146 DIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLF-SEIGFEVLTYQNLT 204
D+ Y+ + RG+ ++F+ +F + R G D + L+ F + + F + T
Sbjct: 339 DLPKYKMDNTPRGICIIFNAENFAVEHLKKRKGTQKDVEALENTFQNNLKFTTQVKNDPT 398
Query: 205 LEQTRATLEQMSSV-LAGYECVFLVVSSHGHE 235
+ + L+++ + + Y+C V+ SHG E
Sbjct: 399 KNEYKECLQEIRRMDHSKYDCFVCVILSHGCE 430
>UniRef50_Q89M43 Cluster: Blr4350 protein; n=9;
Bradyrhizobiaceae|Rep: Blr4350 protein - Bradyrhizobium
japonicum
Length = 522
Score = 35.1 bits (77), Expect = 3.4
Identities = 30/121 (24%), Positives = 48/121 (39%), Gaps = 11/121 (9%)
Query: 192 EIGFEVLTYQNLTLEQTRATLEQMSSVLAGYECVFLVVSSHGHE---RRYSSDTDIRCSD 248
++GF V+ +N + +Q TL + + F + HG E + Y TD+ +
Sbjct: 80 QLGFSVMVAENQSRQQFSETLLAFDRAIEPGDTAFFFYAGHGFEIAGQNYLLPTDVPAAT 139
Query: 249 GKFISLYAIVDYFNNR---KLPNFTDLPKVFIFQACRG-----ENEDFVQGGGALAPAPQ 300
L +R +L N + +F ACR + V GGG LAP Q
Sbjct: 140 EGQEELVRDASILADRIVERLQNKKARTSILVFDACRNNPFERKGTRAVAGGGGLAPMMQ 199
Query: 301 V 301
+
Sbjct: 200 L 200
>UniRef50_A7SXL6 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 180
Score = 34.3 bits (75), Expect = 5.9
Identities = 19/60 (31%), Positives = 27/60 (45%), Gaps = 6/60 (10%)
Query: 228 VVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENED 287
V+ SHG + I +D F+ + I F P PK+F QACRG++ D
Sbjct: 3 VIMSHGGKN------GILTNDLNFVDVDEITGKFQGTNCPQLATKPKLFFIQACRGDDVD 56
>UniRef50_Q9TW65 Cluster: Dystrophin-1; n=4; root|Rep: Dystrophin-1 -
Caenorhabditis elegans
Length = 3674
Score = 34.3 bits (75), Expect = 5.9
Identities = 24/84 (28%), Positives = 41/84 (48%), Gaps = 5/84 (5%)
Query: 169 LLNIEPNRDG--VNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLAGYECVF 226
L N+E R G +N +C++LK ++E+G EV ++ L ++ L+++ LA EC
Sbjct: 2884 LANLEQRRRGLEINANCERLKKNWAELGIEVESWDKL-VQHAMQRLQELERNLA--ECQL 2940
Query: 227 LVVSSHGHERRYSSDTDIRCSDGK 250
+ SS + I D K
Sbjct: 2941 HLTSSENEIETMKAVEKIHLEDLK 2964
>UniRef50_A7RTN5 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 1477
Score = 33.9 bits (74), Expect = 7.8
Identities = 29/108 (26%), Positives = 46/108 (42%), Gaps = 10/108 (9%)
Query: 159 VLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV 218
VL F Y + I P+R V V C L + E G++ L Q+ R + S+
Sbjct: 554 VLFTFRYYDIVSMIGPDRSCVAVKC--LGKVLMEFGWKDLKNQDRWNVLDRVPSSSVYSI 611
Query: 219 LAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVD-YFNNRK 265
+ G+ C FL + D DI ++ Y + D Y+NN++
Sbjct: 612 VIGWICEFL-------DECNRQDQDILSEVALYLPKYVLFDPYYNNKR 652
>UniRef50_A2G8I8 Cluster: Putative uncharacterized protein; n=1;
Trichomonas vaginalis G3|Rep: Putative uncharacterized
protein - Trichomonas vaginalis G3
Length = 123
Score = 33.9 bits (74), Expect = 7.8
Identities = 18/56 (32%), Positives = 32/56 (57%), Gaps = 1/56 (1%)
Query: 7 KAIQRNFSSLV-EGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYREI 61
+A+ FS+++ E D++S V +E G ++ +P + IT + R+LYREI
Sbjct: 17 QALHNKFSNVLDEIKDINSKVNFFFEDGEEEEEEADPLFQSQITREQEIRLLYREI 72
>UniRef50_Q5X4J1 Cluster: [Protein-PII] uridylyltransferase; n=4;
Legionella pneumophila|Rep: [Protein-PII]
uridylyltransferase - Legionella pneumophila (strain
Paris)
Length = 861
Score = 33.9 bits (74), Expect = 7.8
Identities = 20/91 (21%), Positives = 46/91 (50%), Gaps = 4/91 (4%)
Query: 126 AIPCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDK 185
A+ F+VK +F +D+ + QL+ + + G+L S + LNI + + ++
Sbjct: 766 ALTHFNVKTQINFIDDNTNHQTQLFLVTNDRPGLLATISRVFLTLNIHLHNAKIATAGER 825
Query: 186 LK---YLFSEIGFEVLTYQNLTLEQTRATLE 213
++ Y+ ++ G+ L ++ T+ + + LE
Sbjct: 826 VEDMFYISNQTGYS-LNHEEKTILKEKLILE 855
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.322 0.138 0.414
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 432,674,060
Number of Sequences: 1657284
Number of extensions: 17136520
Number of successful extensions: 33259
Number of sequences better than 10.0: 134
Number of HSP's better than 10.0 without gapping: 94
Number of HSP's successfully gapped in prelim test: 40
Number of HSP's that attempted gapping in prelim test: 32940
Number of HSP's gapped (non-prelim): 251
length of query: 410
length of database: 575,637,011
effective HSP length: 103
effective length of query: 307
effective length of database: 404,936,759
effective search space: 124315585013
effective search space used: 124315585013
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 74 (33.9 bits)
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