Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002841-TA|BGIBMGA002841-PA|IPR001315|Caspase
Recruitment, IPR002138|Peptidase C14, caspase non-catalytic subunit
p10, IPR001309|Caspase, p20 subunit, IPR011600|Peptidase C14, caspase
catalytic, IPR002398|Peptidase C14, caspase precursor p45,
IPR011029|DEATH-like
(410 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AB209147-1|BAD92384.1| 456|Homo sapiens caspase 9 isoform alpha... 107 7e-23
U13021-1|AAA58959.1| 435|Homo sapiens ICH-1L protein. 106 2e-22
AY219042-1|AAO25653.1| 435|Homo sapiens caspase 2, apoptosis-re... 106 2e-22
AC073342-1|AAP22346.1| 435|Homo sapiens unknown protein. 106 2e-22
BT006911-1|AAP35557.1| 416|Homo sapiens caspase 9, apoptosis-re... 105 3e-22
BC006463-1|AAH06463.1| 416|Homo sapiens caspase 9, apoptosis-re... 105 3e-22
BC002452-1|AAH02452.1| 416|Homo sapiens caspase 9, apoptosis-re... 105 3e-22
AL512883-7|CAC42423.1| 416|Homo sapiens caspase 9, apoptosis-re... 105 3e-22
BT007240-1|AAP35904.1| 435|Homo sapiens caspase 2, apoptosis-re... 105 4e-22
BC002427-1|AAH02427.2| 452|Homo sapiens caspase 2, apoptosis-re... 105 4e-22
AY214168-1|AAO21133.1| 416|Homo sapiens caspase 9, apoptosis-re... 103 1e-21
U60521-1|AAC50776.1| 416|Homo sapiens proMch6 protein. 102 2e-21
U56390-1|AAC50640.1| 416|Homo sapiens ICE-LAP6 protein. 102 2e-21
AB019205-1|BAA82697.1| 416|Homo sapiens Caspase-9 protein. 102 2e-21
BC004460-1|AAH04460.1| 293|Homo sapiens caspase 6, apoptosis-re... 99 2e-20
BC000305-1|AAH00305.1| 293|Homo sapiens caspase 6, apoptosis-re... 99 2e-20
AY254046-1|AAO63494.1| 293|Homo sapiens caspase 6, apoptosis-re... 99 2e-20
U20536-1|AAC50168.1| 293|Homo sapiens cysteine protease Mch2 is... 96 2e-19
BC103869-1|AAI03870.1| 242|Homo sapiens caspase 14, apoptosis-r... 83 2e-15
BC103868-1|AAI03869.1| 242|Homo sapiens caspase 14, apoptosis-r... 83 2e-15
BC069541-1|AAH69541.1| 242|Homo sapiens caspase 14, apoptosis-r... 83 2e-15
AF097874-1|AAD16173.1| 242|Homo sapiens caspase 14 precursor pr... 83 2e-15
U13022-1|AAA58960.1| 312|Homo sapiens ICH-1S protein. 76 2e-13
CR541748-1|CAG46548.1| 312|Homo sapiens CASP2 protein. 76 2e-13
AC073342-3|AAP22347.1| 312|Homo sapiens unknown protein. 76 2e-13
U86214-1|AAB46730.1| 521|Homo sapiens Fas-associated death doma... 75 6e-13
U60519-1|AAC50644.1| 479|Homo sapiens apoptotic cysteine protea... 75 6e-13
EF050529-1|ABJ53426.1| 522|Homo sapiens caspase 10, apoptosis-r... 75 6e-13
BC042844-1|AAH42844.1| 522|Homo sapiens CASP10 protein protein. 75 6e-13
AJ487679-1|CAD32372.1| 478|Homo sapiens caspase 10 protein. 75 6e-13
AC007283-1|AAY24291.1| 522|Homo sapiens unknown protein. 75 6e-13
AB038979-2|BAB32553.1| 479|Homo sapiens caspase-10a protein. 75 6e-13
AB038979-1|BAB32554.1| 521|Homo sapiens caspase-10b protein. 75 6e-13
AF111345-1|AAD28403.1| 522|Homo sapiens caspase-10/d protein. 74 8e-13
U39613-1|AAC50346.1| 303|Homo sapiens ICE-LAP3 protein. 69 4e-11
U67320-1|AAC51153.1| 303|Homo sapiens Lice2 gamma cysteine prot... 68 5e-11
U67319-1|AAC51152.1| 336|Homo sapiens Lice2 beta cysteine prote... 68 5e-11
U67206-1|AAF21460.1| 303|Homo sapiens Lice2 alpha protein. 68 5e-11
U40281-1|AAC50352.1| 303|Homo sapiens CMH-1 protein. 68 5e-11
U37448-1|AAC50303.1| 303|Homo sapiens Mch3 isoform alpha protein. 68 5e-11
BT006683-1|AAP35329.1| 303|Homo sapiens caspase 7, apoptosis-re... 68 5e-11
BC015799-1|AAH15799.1| 303|Homo sapiens caspase 7, apoptosis-re... 68 5e-11
AL627395-1|CAI16004.1| 303|Homo sapiens caspase 7, apoptosis-re... 68 5e-11
AL592546-4|CAI12638.1| 303|Homo sapiens caspase 7, apoptosis-re... 68 5e-11
AF078533-1|AAC28380.1| 377|Homo sapiens evolutionarily related ... 68 7e-11
Z48810-1|CAA88750.1| 377|Homo sapiens TX protease precursor pro... 66 3e-10
U28979-2|AAC99854.1| 286|Homo sapiens Mih1/TX isoform delta pro... 66 3e-10
U28978-1|AAC99852.1| 321|Homo sapiens Mih1/TX isoform gamma pro... 66 3e-10
U28977-1|AAC99851.1| 331|Homo sapiens Mih1/TX isoform beta prot... 66 3e-10
U28976-1|AAC99850.1| 377|Homo sapiens Mih1/TX isoform alpha pro... 66 3e-10
U28015-1|AAA75172.1| 418|Homo sapiens cysteine protease protein. 66 3e-10
U28014-1|AAA75171.1| 377|Homo sapiens cysteine protease protein. 66 3e-10
U25804-1|AAA86890.1| 377|Homo sapiens Ich-2 protein. 66 3e-10
DQ508420-1|ABF47103.1| 418|Homo sapiens caspase 5, apoptosis-re... 66 3e-10
DQ228677-1|ABB58703.1| 447|Homo sapiens caspase-5/f protein. 66 3e-10
DQ228674-1|ABB58700.1| 292|Homo sapiens caspase-5/c protein. 66 3e-10
DQ228673-1|ABB58699.1| 376|Homo sapiens caspase-5/b protein. 66 3e-10
DQ228672-1|ABB58698.1| 434|Homo sapiens caspase-5/a protein. 66 3e-10
BC017839-1|AAH17839.1| 377|Homo sapiens caspase 4, apoptosis-re... 66 3e-10
X98173-1|CAA66854.1| 464|Homo sapiens MACH-alpha-2 protein. 65 4e-10
X98172-1|CAA66853.1| 479|Homo sapiens MACH-alpha-1 protein. 65 4e-10
X94993-1|CAA64450.1| 364|Homo sapiens TY protease protein. 65 4e-10
X65019-1|CAA46153.1| 404|Homo sapiens interleukin-1B converting... 65 4e-10
U60520-1|AAC50645.1| 496|Homo sapiens apoptotic cysteine protea... 65 4e-10
M87507-1|AAA66942.1| 404|Homo sapiens interleukin 1-beta conver... 65 4e-10
DQ355026-1|ABC67468.1| 496|Homo sapiens caspase 8, apoptosis-re... 65 4e-10
BC113406-1|AAI13407.1| 418|Homo sapiens caspase 5, apoptosis-re... 65 4e-10
BC074994-1|AAH74994.1| 418|Homo sapiens caspase 5, apoptosis-re... 65 4e-10
AF422925-1|AAL87628.1| 538|Homo sapiens procaspase-8L protein. 65 4e-10
AF009620-1|AAB70913.1| 464|Homo sapiens apoptotic caspase Mch5-... 65 4e-10
AC007256-3|AAY24225.1| 496|Homo sapiens unknown protein. 65 4e-10
AB038985-1|BAB32555.1| 496|Homo sapiens caspase-8 protein. 65 4e-10
U58143-1|AAC50602.1| 479|Homo sapiens FADD-homologous ICE/CED-3... 64 6e-10
AL512883-5|CAI12972.1| 266|Homo sapiens caspase 9, apoptosis-re... 64 9e-10
AF102146-1|AAD24962.1| 479|Homo sapiens caspase 8 protein. 64 9e-10
U26943-1|AAA74929.1| 277|Homo sapiens Yama protein protein. 62 3e-09
U13738-1|AAB60355.1| 277|Homo sapiens cysteine protease CPP32 i... 62 3e-09
U13697-1|AAC50107.1| 383|Homo sapiens Interleukin 1-beta conver... 62 3e-09
BC041689-1|AAH41689.1| 380|Homo sapiens CASP1 protein protein. 62 3e-09
BC016926-1|AAH16926.1| 277|Homo sapiens caspase 3, apoptosis-re... 62 3e-09
AY219866-1|AAO25654.1| 277|Homo sapiens caspase 3, apoptosis-re... 62 3e-09
AJ487678-1|CAD32371.1| 455|Homo sapiens caspase 10 protein. 62 3e-09
U13737-1|AAA65015.1| 277|Homo sapiens cysteine protease CPP32 i... 62 3e-09
AJ413269-1|CAC88866.1| 277|Homo sapiens caspase-3 protein. 62 3e-09
AK223503-1|BAD97223.1| 404|Homo sapiens caspase 1 isoform alpha... 61 6e-09
U13698-1|AAC50108.1| 311|Homo sapiens interleukin 1-beta conver... 61 8e-09
BC062327-1|AAH62327.1| 311|Homo sapiens caspase 1, apoptosis-re... 61 8e-09
AY660536-1|AAT72297.1| 365|Homo sapiens caspase-1 isoform zeta ... 61 8e-09
U20537-1|AAC50169.1| 204|Homo sapiens cysteine protease Mch2 is... 60 1e-08
AL512883-4|CAI12971.1| 197|Homo sapiens caspase 9, apoptosis-re... 59 2e-08
AY358222-1|AAQ88589.1| 341|Homo sapiens CASP12P1 protein. 58 4e-08
X98174-1|CAA66855.1| 266|Homo sapiens MACH-alpha-3 protein. 56 3e-07
U13699-1|AAC50109.1| 263|Homo sapiens Interleukin 1-beta conver... 54 1e-06
AL512883-6|CAI12973.1| 266|Homo sapiens caspase 9, apoptosis-re... 52 5e-06
AF110376-1|AAD13615.1| 266|Homo sapiens caspase-9S precursor pr... 52 5e-06
AF093130-1|AAD12248.1| 266|Homo sapiens caspase 9 short isoform... 52 5e-06
AB020979-1|BAA87905.1| 266|Homo sapiens caspase-9 protein. 52 5e-06
AB015653-1|BAA78780.1| 266|Homo sapiens caspase-9 beta protein. 52 5e-06
AB209640-1|BAD92877.1| 144|Homo sapiens caspase 2 isoform 2 pre... 50 2e-05
AL627395-3|CAI16006.1| 222|Homo sapiens caspase 7, apoptosis-re... 42 0.003
AL592546-5|CAI12640.1| 222|Homo sapiens caspase 7, apoptosis-re... 42 0.003
AF422927-1|AAL87630.1| 339|Homo sapiens procaspase-8 protein. 41 0.007
AL050391-1|CAB43686.2| 104|Homo sapiens hypothetical protein pr... 40 0.021
AL512883-8|CAI12974.1| 254|Homo sapiens caspase 9, apoptosis-re... 38 0.064
AF422928-1|AAL87631.1| 353|Homo sapiens procaspase-8 protein. 36 0.20
AY732490-1|AAV33129.1| 154|Homo sapiens caspase 9 splice varian... 35 0.60
AJ781267-1|CAH03131.1| 95|Homo sapiens caspase-9c protein prot... 35 0.60
BC131610-1|AAI31611.1| 90|Homo sapiens ICEBERG caspase-1 inhib... 32 4.2
AY358231-1|AAQ88598.1| 90|Homo sapiens ICEBERG protein. 32 4.2
AF208005-1|AAG23528.1| 90|Homo sapiens ICEBERG caspase-1 inhib... 32 4.2
U37449-1|AAC50304.1| 253|Homo sapiens Mch3 isoform beta protein. 31 5.6
AL627395-2|CAI16005.1| 253|Homo sapiens caspase 7, apoptosis-re... 31 5.6
AL592546-3|CAI12639.1| 253|Homo sapiens caspase 7, apoptosis-re... 31 5.6
AF314175-1|AAK00300.1| 77|Homo sapiens Casp-2S-Pro protein. 31 9.8
AF314174-1|AAK00299.1| 91|Homo sapiens Casp-2L-Pro protein. 31 9.8
AC073342-4|AAP22349.1| 77|Homo sapiens unknown protein. 31 9.8
AC073342-2|AAP22348.1| 91|Homo sapiens unknown protein. 31 9.8
>AB209147-1|BAD92384.1| 456|Homo sapiens caspase 9 isoform alpha
preproprotein variant protein.
Length = 456
Score = 107 bits (257), Expect = 7e-23
Identities = 103/411 (25%), Positives = 170/411 (41%), Gaps = 15/411 (3%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPY-RDTSITPRERKRILYR 59
M E ++ ++R LVE +D + AL + +F MIE R S + R++ R L
Sbjct: 36 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 95
Query: 60 EITRRGPQAFTMLLEALREMGHWDLVRDLDPNSPLQLRARRPVL----PPTRQGSDAXXX 115
++ RG QA + + L + G D++ + + +P L P +
Sbjct: 96 DLETRGSQALPLFISCLEDTGQ-DMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPE 154
Query: 116 XXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIE-P 174
+ PV I + D+ Y G ++ + ++F
Sbjct: 155 VLRPETPRPVDIGSGGFGDVGALESLRGNADLA-YILSMEPCGHCLIINNVNFCRESGLR 213
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQ-TRATLEQMSSVLAGYECVFLVVSSHG 233
R G N+DC+KL+ FS + F V +LT ++ A LE +C +V+ SHG
Sbjct: 214 TRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHG 273
Query: 234 HERRYSSDTD-IRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGG 292
+ + + +DG +S+ IV+ FN P+ PK+F QAC GE +D
Sbjct: 274 CQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEV 333
Query: 293 GALAP---APQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVK 349
+ +P +P + P S+I ++ ST PGF+S RD K
Sbjct: 334 ASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPK 393
Query: 350 AGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLR-FGR-QTSSVDRWGF 398
+GSWY++ L ++F + AH + L V + GR SV WG+
Sbjct: 394 SGSWYVETLDDIFEQWAHSEDLQSLLLRVSAAFLCKGEGRLLRGSVSSWGW 444
>U13021-1|AAA58959.1| 435|Homo sapiens ICH-1L protein.
Length = 435
Score = 106 bits (254), Expect = 2e-22
Identities = 109/409 (26%), Positives = 171/409 (41%), Gaps = 43/409 (10%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M H++ +++N L + L ++ L EK + + +M E + + + L
Sbjct: 15 MHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQ-AKVGSFSQNVELLNL 73
Query: 61 ITRRGPQAFTMLLEALRE--MGHWD----------------LVRDLDPNSPLQLRARRPV 102
+ +RGPQAF EALRE GH + L D D + P + P+
Sbjct: 74 LPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPL 133
Query: 103 LPPTRQGSDAXXXXXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQL-YRTRSRKRGVLV 161
R +D N PV C VK T F QL YR +SR RG+ +
Sbjct: 134 YKKLRLSTDTVEHSLD-NKDGPV---CLQVKPCTPEF---YQTHFQLAYRLQSRPRGLAL 186
Query: 162 VFSYISFLLNIEPN-RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLA 220
V S + F E R G +VD L LF +G++V + T ++ + L+ + + A
Sbjct: 187 VLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPA 246
Query: 221 GY--ECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIF 278
+ + + SHG E I DGK + L + F+N P+ + PK+F
Sbjct: 247 HRVTDSCIVALLSHGVEGA------IYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFI 300
Query: 279 QACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANST 338
QACRG+ D Q ++ A P S+++ +
Sbjct: 301 QACRGDETD-------RGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYAC 353
Query: 339 LPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFG 387
L G + R+ K GSWYI+ L +VF+ERA D HV ++ V+ ++ R G
Sbjct: 354 LKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREG 402
>AY219042-1|AAO25653.1| 435|Homo sapiens caspase 2,
apoptosis-related cysteine protease (neural precursor
cell expressed protein.
Length = 435
Score = 106 bits (254), Expect = 2e-22
Identities = 109/409 (26%), Positives = 171/409 (41%), Gaps = 43/409 (10%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M H++ +++N L + L ++ L EK + + +M E + + + L
Sbjct: 15 MHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQ-AKVGSFSQNVELLNL 73
Query: 61 ITRRGPQAFTMLLEALRE--MGHWD----------------LVRDLDPNSPLQLRARRPV 102
+ +RGPQAF EALRE GH + L D D + P + P+
Sbjct: 74 LPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPL 133
Query: 103 LPPTRQGSDAXXXXXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQL-YRTRSRKRGVLV 161
R +D N PV C VK T F QL YR +SR RG+ +
Sbjct: 134 YKKLRLSTDTVEHSLD-NKDGPV---CLQVKPCTPEF---YQTHFQLAYRLQSRPRGLAL 186
Query: 162 VFSYISFLLNIEPN-RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLA 220
V S + F E R G +VD L LF +G++V + T ++ + L+ + + A
Sbjct: 187 VLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPA 246
Query: 221 GY--ECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIF 278
+ + + SHG E I DGK + L + F+N P+ + PK+F
Sbjct: 247 HRVTDSCIVALLSHGVEGA------IYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFI 300
Query: 279 QACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANST 338
QACRG+ D Q ++ A P S+++ +
Sbjct: 301 QACRGDETD-------RGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYAC 353
Query: 339 LPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFG 387
L G + R+ K GSWYI+ L +VF+ERA D HV ++ V+ ++ R G
Sbjct: 354 LKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREG 402
>AC073342-1|AAP22346.1| 435|Homo sapiens unknown protein.
Length = 435
Score = 106 bits (254), Expect = 2e-22
Identities = 109/409 (26%), Positives = 171/409 (41%), Gaps = 43/409 (10%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M H++ +++N L + L ++ L EK + + +M E + + + L
Sbjct: 15 MHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQ-AKVGSFSQNVELLNL 73
Query: 61 ITRRGPQAFTMLLEALRE--MGHWD----------------LVRDLDPNSPLQLRARRPV 102
+ +RGPQAF EALRE GH + L D D + P + P+
Sbjct: 74 LPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPL 133
Query: 103 LPPTRQGSDAXXXXXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQL-YRTRSRKRGVLV 161
R +D N PV C VK T F QL YR +SR RG+ +
Sbjct: 134 YKKLRLSTDTVEHSLD-NKDGPV---CLQVKPCTPEF---YQTHFQLAYRLQSRPRGLAL 186
Query: 162 VFSYISFLLNIEPN-RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLA 220
V S + F E R G +VD L LF +G++V + T ++ + L+ + + A
Sbjct: 187 VLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPA 246
Query: 221 GY--ECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIF 278
+ + + SHG E I DGK + L + F+N P+ + PK+F
Sbjct: 247 HRVTDSCIVALLSHGVEGA------IYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFI 300
Query: 279 QACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANST 338
QACRG+ D Q ++ A P S+++ +
Sbjct: 301 QACRGDETD-------RGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYAC 353
Query: 339 LPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFG 387
L G + R+ K GSWYI+ L +VF+ERA D HV ++ V+ ++ R G
Sbjct: 354 LKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREG 402
>BT006911-1|AAP35557.1| 416|Homo sapiens caspase 9,
apoptosis-related cysteine protease protein.
Length = 416
Score = 105 bits (252), Expect = 3e-22
Identities = 97/389 (24%), Positives = 162/389 (41%), Gaps = 13/389 (3%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPY-RDTSITPRERKRILYR 59
M E ++ ++R LVE +D + AL + +F MIE R S + R++ R L
Sbjct: 1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
Query: 60 EITRRGPQAFTMLLEALREMGHWDLVRDLDPNSPLQLRARRPVL----PPTRQGSDAXXX 115
++ RG QA + + L + G D++ + + +P L P +
Sbjct: 61 DLETRGSQALPLFISCLEDTGQ-DMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPE 119
Query: 116 XXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIE-P 174
+ PV I + D+ Y G ++ + ++F
Sbjct: 120 VLRPETPRPVDIGSGGFGDVGALESLRGNADLA-YILSMEPCGHCLIINNVNFCRESGLR 178
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQ-TRATLEQMSSVLAGYECVFLVVSSHG 233
R G N+DC+KL+ FS + F V +LT ++ A LE +C +V+ SHG
Sbjct: 179 TRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHG 238
Query: 234 HERRYSSDTD-IRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGG 292
+ + + +DG +S+ IV+ FN P+ PK+F QAC GE +D
Sbjct: 239 CQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEV 298
Query: 293 GALAP---APQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVK 349
+ +P +P + P S+I ++ ST PGF+S RD K
Sbjct: 299 ASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPK 358
Query: 350 AGSWYIQVLCEVFAERAHDCHVDELFTLV 378
+GSWY++ L ++F + AH + L V
Sbjct: 359 SGSWYVETLDDIFEQWAHSEDLQSLLLRV 387
>BC006463-1|AAH06463.1| 416|Homo sapiens caspase 9,
apoptosis-related cysteine peptidase protein.
Length = 416
Score = 105 bits (252), Expect = 3e-22
Identities = 97/389 (24%), Positives = 162/389 (41%), Gaps = 13/389 (3%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPY-RDTSITPRERKRILYR 59
M E ++ ++R LVE +D + AL + +F MIE R S + R++ R L
Sbjct: 1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
Query: 60 EITRRGPQAFTMLLEALREMGHWDLVRDLDPNSPLQLRARRPVL----PPTRQGSDAXXX 115
++ RG QA + + L + G D++ + + +P L P +
Sbjct: 61 DLETRGSQALPLFISCLEDTGQ-DMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPE 119
Query: 116 XXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIE-P 174
+ PV I + D+ Y G ++ + ++F
Sbjct: 120 VLRPETPRPVDIGSGGFGDVGALESLRGNADLA-YILSMEPCGHCLIINNVNFCRESGLR 178
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQ-TRATLEQMSSVLAGYECVFLVVSSHG 233
R G N+DC+KL+ FS + F V +LT ++ A LE +C +V+ SHG
Sbjct: 179 TRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHG 238
Query: 234 HERRYSSDTD-IRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGG 292
+ + + +DG +S+ IV+ FN P+ PK+F QAC GE +D
Sbjct: 239 CQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEV 298
Query: 293 GALAP---APQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVK 349
+ +P +P + P S+I ++ ST PGF+S RD K
Sbjct: 299 ASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPK 358
Query: 350 AGSWYIQVLCEVFAERAHDCHVDELFTLV 378
+GSWY++ L ++F + AH + L V
Sbjct: 359 SGSWYVETLDDIFEQWAHSEDLQSLLLRV 387
>BC002452-1|AAH02452.1| 416|Homo sapiens caspase 9,
apoptosis-related cysteine peptidase protein.
Length = 416
Score = 105 bits (252), Expect = 3e-22
Identities = 97/389 (24%), Positives = 162/389 (41%), Gaps = 13/389 (3%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPY-RDTSITPRERKRILYR 59
M E ++ ++R LVE +D + AL + +F MIE R S + R++ R L
Sbjct: 1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
Query: 60 EITRRGPQAFTMLLEALREMGHWDLVRDLDPNSPLQLRARRPVL----PPTRQGSDAXXX 115
++ RG QA + + L + G D++ + + +P L P +
Sbjct: 61 DLETRGSQALPLFISCLEDTGQ-DMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPE 119
Query: 116 XXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIE-P 174
+ PV I + D+ Y G ++ + ++F
Sbjct: 120 VLRPETPRPVDIGSGGFGDVGALESLRGNADLA-YILSMEPCGHCLIINNVNFCRESGLR 178
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQ-TRATLEQMSSVLAGYECVFLVVSSHG 233
R G N+DC+KL+ FS + F V +LT ++ A LE +C +V+ SHG
Sbjct: 179 TRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHG 238
Query: 234 HERRYSSDTD-IRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGG 292
+ + + +DG +S+ IV+ FN P+ PK+F QAC GE +D
Sbjct: 239 CQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEV 298
Query: 293 GALAP---APQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVK 349
+ +P +P + P S+I ++ ST PGF+S RD K
Sbjct: 299 ASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPK 358
Query: 350 AGSWYIQVLCEVFAERAHDCHVDELFTLV 378
+GSWY++ L ++F + AH + L V
Sbjct: 359 SGSWYVETLDDIFEQWAHSEDLQSLLLRV 387
>AL512883-7|CAC42423.1| 416|Homo sapiens caspase 9,
apoptosis-related cysteine peptidase protein.
Length = 416
Score = 105 bits (252), Expect = 3e-22
Identities = 97/389 (24%), Positives = 162/389 (41%), Gaps = 13/389 (3%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPY-RDTSITPRERKRILYR 59
M E ++ ++R LVE +D + AL + +F MIE R S + R++ R L
Sbjct: 1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
Query: 60 EITRRGPQAFTMLLEALREMGHWDLVRDLDPNSPLQLRARRPVL----PPTRQGSDAXXX 115
++ RG QA + + L + G D++ + + +P L P +
Sbjct: 61 DLETRGSQALPLFISCLEDTGQ-DMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPE 119
Query: 116 XXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIE-P 174
+ PV I + D+ Y G ++ + ++F
Sbjct: 120 VLRPETPRPVDIGSGGFGDVGALESLRGNADLA-YILSMEPCGHCLIINNVNFCRESGLR 178
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQ-TRATLEQMSSVLAGYECVFLVVSSHG 233
R G N+DC+KL+ FS + F V +LT ++ A LE +C +V+ SHG
Sbjct: 179 TRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHG 238
Query: 234 HERRYSSDTD-IRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGG 292
+ + + +DG +S+ IV+ FN P+ PK+F QAC GE +D
Sbjct: 239 CQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEV 298
Query: 293 GALAP---APQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVK 349
+ +P +P + P S+I ++ ST PGF+S RD K
Sbjct: 299 ASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPK 358
Query: 350 AGSWYIQVLCEVFAERAHDCHVDELFTLV 378
+GSWY++ L ++F + AH + L V
Sbjct: 359 SGSWYVETLDDIFEQWAHSEDLQSLLLRV 387
>BT007240-1|AAP35904.1| 435|Homo sapiens caspase 2,
apoptosis-related cysteine protease (neural precursor
cell expressed protein.
Length = 435
Score = 105 bits (251), Expect = 4e-22
Identities = 108/409 (26%), Positives = 171/409 (41%), Gaps = 43/409 (10%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M H++ +++N L + L ++ L EK + + +M E + + + L
Sbjct: 15 MHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQ-AKVGSFSQNVELLNL 73
Query: 61 ITRRGPQAFTMLLEALRE--MGHWD----------------LVRDLDPNSPLQLRARRPV 102
+ +RGPQAF EALRE GH + L D D + P + P+
Sbjct: 74 LPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPL 133
Query: 103 LPPTRQGSDAXXXXXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQL-YRTRSRKRGVLV 161
R +D N P+ C VK T F QL YR +SR RG+ +
Sbjct: 134 YKKLRLSTDTVEHSLD-NKDGPL---CLQVKPCTPEF---YQTHFQLAYRLQSRPRGLAL 186
Query: 162 VFSYISFLLNIEPN-RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLA 220
V S + F E R G +VD L LF +G++V + T ++ + L+ + + A
Sbjct: 187 VLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPA 246
Query: 221 GY--ECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIF 278
+ + + SHG E I DGK + L + F+N P+ + PK+F
Sbjct: 247 HRVTDSCIVALLSHGVEGA------IYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFI 300
Query: 279 QACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANST 338
QACRG+ D Q ++ A P S+++ +
Sbjct: 301 QACRGDETD-------RGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYAC 353
Query: 339 LPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFG 387
L G + R+ K GSWYI+ L +VF+ERA D HV ++ V+ ++ R G
Sbjct: 354 LKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREG 402
>BC002427-1|AAH02427.2| 452|Homo sapiens caspase 2,
apoptosis-related cysteine peptidase (neural precursor
cell expresse protein.
Length = 452
Score = 105 bits (251), Expect = 4e-22
Identities = 108/409 (26%), Positives = 171/409 (41%), Gaps = 43/409 (10%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M H++ +++N L + L ++ L EK + + +M E + + + L
Sbjct: 32 MHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQ-AKVGSFSQNVELLNL 90
Query: 61 ITRRGPQAFTMLLEALRE--MGHWD----------------LVRDLDPNSPLQLRARRPV 102
+ +RGPQAF EALRE GH + L D D + P + P+
Sbjct: 91 LPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPL 150
Query: 103 LPPTRQGSDAXXXXXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQL-YRTRSRKRGVLV 161
R +D N P+ C VK T F QL YR +SR RG+ +
Sbjct: 151 YKKLRLSTDTVEHSLD-NKDGPL---CLQVKPCTPEF---YQTHFQLAYRLQSRPRGLAL 203
Query: 162 VFSYISFLLNIEPN-RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLA 220
V S + F E R G +VD L LF +G++V + T ++ + L+ + + A
Sbjct: 204 VLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPA 263
Query: 221 GY--ECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIF 278
+ + + SHG E I DGK + L + F+N P+ + PK+F
Sbjct: 264 HRVTDSCIVALLSHGVEGA------IYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFI 317
Query: 279 QACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANST 338
QACRG+ D Q ++ A P S+++ +
Sbjct: 318 QACRGDETD-------RGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYAC 370
Query: 339 LPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFG 387
L G + R+ K GSWYI+ L +VF+ERA D HV ++ V+ ++ R G
Sbjct: 371 LKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREG 419
>AY214168-1|AAO21133.1| 416|Homo sapiens caspase 9,
apoptosis-related cysteine protease protein.
Length = 416
Score = 103 bits (247), Expect = 1e-21
Identities = 96/389 (24%), Positives = 161/389 (41%), Gaps = 13/389 (3%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPY-RDTSITPRERKRILYR 59
M E ++ ++R LVE +D + L + +F MIE R S + R++ R L
Sbjct: 1 MDEADRRLLRRCRLRLVEELQVDQLWDVLLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
Query: 60 EITRRGPQAFTMLLEALREMGHWDLVRDLDPNSPLQLRARRPVL----PPTRQGSDAXXX 115
++ RG QA + + L + G D++ + + +P L P +
Sbjct: 61 DLETRGSQALPLFISCLEDTGQ-DMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPE 119
Query: 116 XXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIE-P 174
+ PV I + D+ Y G ++ + ++F
Sbjct: 120 VLRPETPRPVDIGSGGFGDVGALESLRGNADLA-YILSMEPCGHCLIINNVNFCRESGLR 178
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQ-TRATLEQMSSVLAGYECVFLVVSSHG 233
R G N+DC+KL+ FS + F V +LT ++ A LE +C +V+ SHG
Sbjct: 179 TRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELARQDHGALDCCVVVILSHG 238
Query: 234 HERRYSSDTD-IRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGG 292
+ + + +DG +S+ IV+ FN P+ PK+F QAC GE +D
Sbjct: 239 CQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEV 298
Query: 293 GALAP---APQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVK 349
+ +P +P + P S+I ++ ST PGF+S RD K
Sbjct: 299 ASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPK 358
Query: 350 AGSWYIQVLCEVFAERAHDCHVDELFTLV 378
+GSWY++ L ++F + AH + L V
Sbjct: 359 SGSWYVETLDDIFEQWAHSEDLQSLLLRV 387
>U60521-1|AAC50776.1| 416|Homo sapiens proMch6 protein.
Length = 416
Score = 102 bits (245), Expect = 2e-21
Identities = 97/389 (24%), Positives = 160/389 (41%), Gaps = 13/389 (3%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPY-RDTSITPRERKRILYR 59
M E ++ ++R LVE +D + AL +F MIE R S + R++ R L
Sbjct: 1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSSELFRPHMIEDIQRAGSGSRRDQARQLII 60
Query: 60 EITRRGPQAFTMLLEALREMGHWDLVRDLDPNSPLQLRARRPVL----PPTRQGSDAXXX 115
++ RG QA + + L + G D++ + + +P L P +
Sbjct: 61 DLETRGSQALPLFISCLEDTGQ-DMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPE 119
Query: 116 XXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIE-P 174
+ PV I + D+ Y G ++ + ++F
Sbjct: 120 VLRPETPRPVDIGSGGFGDVGALESLRGNADLA-YILSMEPCGHCLIINNVNFCRESGLR 178
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQ-TRATLEQMSSVLAGYECVFLVVSSHG 233
R G N+DC+KL+ FS F V +LT ++ A LE +C +V+ SHG
Sbjct: 179 TRTGSNIDCEKLRRRFSSPHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHG 238
Query: 234 HERRYSSDTD-IRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGG 292
+ + + +DG +S+ IV+ FN P+ PK+F QAC GE +D
Sbjct: 239 CQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEV 298
Query: 293 GALAP---APQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVK 349
+ +P +P + P S+I ++ ST PGF+S RD K
Sbjct: 299 ASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPK 358
Query: 350 AGSWYIQVLCEVFAERAHDCHVDELFTLV 378
+GSWY++ L ++F + AH + L V
Sbjct: 359 SGSWYVETLDDIFEQWAHSEDLQSLLLRV 387
>U56390-1|AAC50640.1| 416|Homo sapiens ICE-LAP6 protein.
Length = 416
Score = 102 bits (245), Expect = 2e-21
Identities = 98/389 (25%), Positives = 160/389 (41%), Gaps = 13/389 (3%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPY-RDTSITPRERKRILYR 59
M E ++ ++R LVE +D + L + +F MIE R S + R++ R L
Sbjct: 1 MDEADRRLLRRCRLRLVEELQVDQLWDVLLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
Query: 60 EITRRGPQAFTMLLEALREMGHWDLVRDLDPNSPLQLRARRPVL----PPTRQGSDAXXX 115
++ RG QA + + L + G L L N + +P L P +
Sbjct: 61 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAG-KLSKPTLENLTPVVLRPEIRKPE 119
Query: 116 XXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIE-P 174
+ PV I + D+ Y G ++ + ++F
Sbjct: 120 VLRPETPRPVDIGSGGFGDVGALESLRGNADLA-YILSMEPCGHCLIINNVNFCRESGLR 178
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQ-TRATLEQMSSVLAGYECVFLVVSSHG 233
R G N+DC+KL+ FS + F V +LT ++ A LE +C +V+ SHG
Sbjct: 179 TRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELARQDHGALDCCVVVILSHG 238
Query: 234 HERRYSSDTD-IRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGG 292
+ + + +DG +S+ IV+ FN P+ PK+F QAC GE +D
Sbjct: 239 CQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEV 298
Query: 293 GALAP---APQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVK 349
+ +P +P + P S+I ++ ST PGF+S RD K
Sbjct: 299 ASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPK 358
Query: 350 AGSWYIQVLCEVFAERAHDCHVDELFTLV 378
+GSWY++ L ++F + AH + L V
Sbjct: 359 SGSWYVETLDDIFEQWAHSEDLQSLLLRV 387
>AB019205-1|BAA82697.1| 416|Homo sapiens Caspase-9 protein.
Length = 416
Score = 102 bits (245), Expect = 2e-21
Identities = 97/389 (24%), Positives = 160/389 (41%), Gaps = 13/389 (3%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPY-RDTSITPRERKRILYR 59
M E ++ ++R LVE +D + AL +F MIE R S + R++ R L
Sbjct: 1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSSELFRPHMIEDIQRAGSGSRRDQARQLII 60
Query: 60 EITRRGPQAFTMLLEALREMGHWDLVRDLDPNSPLQLRARRPVL----PPTRQGSDAXXX 115
++ RG QA + + L + G D++ + + +P L P +
Sbjct: 61 DLETRGSQALPLFISCLEDTGQ-DMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPE 119
Query: 116 XXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIE-P 174
+ PV I + D+ Y G ++ + ++F
Sbjct: 120 VLRPETPRPVDIGSGGFGDVGALESLRGNADLA-YILSMEPCGHCLIINNVNFCRESGLR 178
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQ-TRATLEQMSSVLAGYECVFLVVSSHG 233
R G N+DC+KL+ FS F V +LT ++ A LE +C +V+ SHG
Sbjct: 179 TRTGSNIDCEKLRRRFSSPHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHG 238
Query: 234 HERRYSSDTD-IRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGG 292
+ + + +DG +S+ IV+ FN P+ PK+F QAC GE +D
Sbjct: 239 CQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEV 298
Query: 293 GALAP---APQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVK 349
+ +P +P + P S+I ++ ST PGF+S RD K
Sbjct: 299 ASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPK 358
Query: 350 AGSWYIQVLCEVFAERAHDCHVDELFTLV 378
+GSWY++ L ++F + AH + L V
Sbjct: 359 SGSWYVETLDDIFEQWAHSEDLQSLLLRV 387
>BC004460-1|AAH04460.1| 293|Homo sapiens caspase 6,
apoptosis-related cysteine peptidase protein.
Length = 293
Score = 99.1 bits (236), Expect = 2e-20
Identities = 69/250 (27%), Positives = 109/250 (43%), Gaps = 17/250 (6%)
Query: 138 FFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIE-PNRDGVNVDCDKLKYLFSEIGFE 196
F++ ++ + Y+ R+RG+ ++F++ F ++ P R G D D L FS++GFE
Sbjct: 25 FYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFE 84
Query: 197 VLTYQNLTLEQTRATLEQMSSVL-AGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLY 255
V + +L E+ + ++S+V A +C V SHG I D K I +
Sbjct: 85 VKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHG------EGNHIYAYDAK-IEIQ 137
Query: 256 AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXX 315
+ F K + PK+FI QACRG D + P V
Sbjct: 138 TLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDV-----PVIPLDVVDNQ---TEKLDTNI 189
Query: 316 XXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELF 375
P ++ L+ S G+ SHR+ GSWYIQ LCE+ + EL
Sbjct: 190 TEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELL 249
Query: 376 TLVDKRLRLR 385
TLV++++ R
Sbjct: 250 TLVNRKVSQR 259
>BC000305-1|AAH00305.1| 293|Homo sapiens caspase 6,
apoptosis-related cysteine peptidase protein.
Length = 293
Score = 99.1 bits (236), Expect = 2e-20
Identities = 69/250 (27%), Positives = 109/250 (43%), Gaps = 17/250 (6%)
Query: 138 FFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIE-PNRDGVNVDCDKLKYLFSEIGFE 196
F++ ++ + Y+ R+RG+ ++F++ F ++ P R G D D L FS++GFE
Sbjct: 25 FYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFE 84
Query: 197 VLTYQNLTLEQTRATLEQMSSVL-AGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLY 255
V + +L E+ + ++S+V A +C V SHG I D K I +
Sbjct: 85 VKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHG------EGNHIYAYDAK-IEIQ 137
Query: 256 AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXX 315
+ F K + PK+FI QACRG D + P V
Sbjct: 138 TLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDV-----PVIPLDVVDNQ---TEKLDTNI 189
Query: 316 XXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELF 375
P ++ L+ S G+ SHR+ GSWYIQ LCE+ + EL
Sbjct: 190 TEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELL 249
Query: 376 TLVDKRLRLR 385
TLV++++ R
Sbjct: 250 TLVNRKVSQR 259
>AY254046-1|AAO63494.1| 293|Homo sapiens caspase 6,
apoptosis-related cysteine protease protein.
Length = 293
Score = 99.1 bits (236), Expect = 2e-20
Identities = 69/250 (27%), Positives = 109/250 (43%), Gaps = 17/250 (6%)
Query: 138 FFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIE-PNRDGVNVDCDKLKYLFSEIGFE 196
F++ ++ + Y+ R+RG+ ++F++ F ++ P R G D D L FS++GFE
Sbjct: 25 FYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFE 84
Query: 197 VLTYQNLTLEQTRATLEQMSSVL-AGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLY 255
V + +L E+ + ++S+V A +C V SHG I D K I +
Sbjct: 85 VKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHG------EGNHIYAYDAK-IEIQ 137
Query: 256 AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXX 315
+ F K + PK+FI QACRG D + P V
Sbjct: 138 TLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDV-----PVIPLDVVDNQ---TEKLDTNI 189
Query: 316 XXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELF 375
P ++ L+ S G+ SHR+ GSWYIQ LCE+ + EL
Sbjct: 190 TEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELL 249
Query: 376 TLVDKRLRLR 385
TLV++++ R
Sbjct: 250 TLVNRKVSQR 259
>U20536-1|AAC50168.1| 293|Homo sapiens cysteine protease Mch2
isoform alpha protein.
Length = 293
Score = 95.9 bits (228), Expect = 2e-19
Identities = 68/250 (27%), Positives = 108/250 (43%), Gaps = 17/250 (6%)
Query: 138 FFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIE-PNRDGVNVDCDKLKYLFSEIGFE 196
F++ ++ + Y+ R+RG+ ++F++ F ++ P R D D L FS++GFE
Sbjct: 25 FYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRRTCADRDNLTRRFSDLGFE 84
Query: 197 VLTYQNLTLEQTRATLEQMSSVL-AGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLY 255
V + +L E+ + ++S+V A +C V SHG I D K I +
Sbjct: 85 VKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHGEGNH------IYAYDAK-IEIQ 137
Query: 256 AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXX 315
+ F K + PK+FI QACRG D + P V
Sbjct: 138 TLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDV-----PVIPLDVVDNQ---TEKLDTNI 189
Query: 316 XXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELF 375
P ++ L+ S G+ SHR+ GSWYIQ LCE+ + EL
Sbjct: 190 TEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELL 249
Query: 376 TLVDKRLRLR 385
TLV++++ R
Sbjct: 250 TLVNRKVSQR 259
>BC103869-1|AAI03870.1| 242|Homo sapiens caspase 14,
apoptosis-related cysteine peptidase protein.
Length = 242
Score = 83.0 bits (196), Expect = 2e-15
Identities = 63/221 (28%), Positives = 101/221 (45%), Gaps = 30/221 (13%)
Query: 166 ISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLAGYE-- 223
++ +L + R+G D D L+++F ++ FE ++ T EQ + LE+ + E
Sbjct: 19 LALILCVTKAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDP 78
Query: 224 --CVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQAC 281
C F+V+ +HG E + DG+ + L + + NN+ PKV+I QAC
Sbjct: 79 VSCAFVVLMAHGREGFLKGE------DGEMVKLENLFEALNNKNCQALRAKPKVYIIQAC 132
Query: 282 RGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPG 341
RGE D P V D V P Y++ L ST+ G
Sbjct: 133 RGEQRD---------PGETVGGDEIVMVIKDSPQTI---------PTYTDALHVYSTVEG 174
Query: 342 FISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRL 382
+I++R + GS +IQ L +VF +R H+ EL T V +R+
Sbjct: 175 YIAYRHDQKGSCFIQTLVDVFTKRKG--HILELLTEVTRRM 213
>BC103868-1|AAI03869.1| 242|Homo sapiens caspase 14,
apoptosis-related cysteine peptidase protein.
Length = 242
Score = 83.0 bits (196), Expect = 2e-15
Identities = 63/221 (28%), Positives = 101/221 (45%), Gaps = 30/221 (13%)
Query: 166 ISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLAGYE-- 223
++ +L + R+G D D L+++F ++ FE ++ T EQ + LE+ + E
Sbjct: 19 LALILCVTKAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDP 78
Query: 224 --CVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQAC 281
C F+V+ +HG E + DG+ + L + + NN+ PKV+I QAC
Sbjct: 79 VSCAFVVLMAHGREGFLKGE------DGEMVKLENLFEALNNKNCQALRAKPKVYIIQAC 132
Query: 282 RGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPG 341
RGE D P V D V P Y++ L ST+ G
Sbjct: 133 RGEQRD---------PGETVGGDEIVMVIKDSPQTI---------PTYTDALHVYSTVEG 174
Query: 342 FISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRL 382
+I++R + GS +IQ L +VF +R H+ EL T V +R+
Sbjct: 175 YIAYRHDQKGSCFIQTLVDVFTKRKG--HILELLTEVTRRM 213
>BC069541-1|AAH69541.1| 242|Homo sapiens caspase 14,
apoptosis-related cysteine peptidase protein.
Length = 242
Score = 83.0 bits (196), Expect = 2e-15
Identities = 63/221 (28%), Positives = 101/221 (45%), Gaps = 30/221 (13%)
Query: 166 ISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLAGYE-- 223
++ +L + R+G D D L+++F ++ FE ++ T EQ + LE+ + E
Sbjct: 19 LALILCVTKAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDP 78
Query: 224 --CVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQAC 281
C F+V+ +HG E + DG+ + L + + NN+ PKV+I QAC
Sbjct: 79 VSCAFVVLMAHGREGFLKGE------DGEMVKLENLFEALNNKNCQALRAKPKVYIIQAC 132
Query: 282 RGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPG 341
RGE D P V D V P Y++ L ST+ G
Sbjct: 133 RGEQRD---------PGETVGGDEIVMVIKDSPQTI---------PTYTDALHVYSTVEG 174
Query: 342 FISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRL 382
+I++R + GS +IQ L +VF +R H+ EL T V +R+
Sbjct: 175 YIAYRHDQKGSCFIQTLVDVFTKRKG--HILELLTEVTRRM 213
>AF097874-1|AAD16173.1| 242|Homo sapiens caspase 14 precursor
protein.
Length = 242
Score = 83.0 bits (196), Expect = 2e-15
Identities = 63/221 (28%), Positives = 101/221 (45%), Gaps = 30/221 (13%)
Query: 166 ISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLAGYE-- 223
++ +L + R+G D D L+++F ++ FE ++ T EQ + LE+ + E
Sbjct: 19 LALILCVTKAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDP 78
Query: 224 --CVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQAC 281
C F+V+ +HG E + DG+ + L + + NN+ PKV+I QAC
Sbjct: 79 VSCAFVVLMAHGREGFLKGE------DGEMVKLENLFEALNNKNCQALRAKPKVYIIQAC 132
Query: 282 RGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPG 341
RGE D P V D V P Y++ L ST+ G
Sbjct: 133 RGEQRD---------PGETVGGDEIVMVIKDSPQTI---------PTYTDALHVYSTVEG 174
Query: 342 FISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRL 382
+I++R + GS +IQ L +VF +R H+ EL T V +R+
Sbjct: 175 YIAYRHDQKGSCFIQTLVDVFTKRKG--HILELLTEVTRRM 213
>U13022-1|AAA58960.1| 312|Homo sapiens ICH-1S protein.
Length = 312
Score = 76.2 bits (179), Expect = 2e-13
Identities = 83/305 (27%), Positives = 128/305 (41%), Gaps = 36/305 (11%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M H++ +++N L + L ++ L EK + + +M E + + + L
Sbjct: 1 MHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQ-AKVGSFSQNVELLNL 59
Query: 61 ITRRGPQAFTMLLEALRE--MGHWD----------------LVRDLDPNSPLQLRARRPV 102
+ +RGPQAF EALRE GH + L D D + P + P+
Sbjct: 60 LPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPL 119
Query: 103 LPPTRQGSDAXXXXXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQL-YRTRSRKRGVLV 161
R +D N PV C VK T F QL YR +SR RG+ +
Sbjct: 120 YKKLRLSTDTVEHSLD-NKDGPV---CLQVKPCTPEF---YQTHFQLAYRLQSRPRGLAL 172
Query: 162 VFSYISFLLNIEPN-RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLA 220
V S + F E R G +VD L LF +G++V + T ++ + L+ + + A
Sbjct: 173 VLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPA 232
Query: 221 GY--ECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIF 278
+ + + SHG E I DGK + L + F+N P+ + PK+F
Sbjct: 233 HRVTDSCIVALLSHGVEGA------IYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFI 286
Query: 279 QACRG 283
QACRG
Sbjct: 287 QACRG 291
>CR541748-1|CAG46548.1| 312|Homo sapiens CASP2 protein.
Length = 312
Score = 76.2 bits (179), Expect = 2e-13
Identities = 83/305 (27%), Positives = 128/305 (41%), Gaps = 36/305 (11%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M H++ +++N L + L ++ L EK + + +M E + + + L
Sbjct: 1 MHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQ-AKVGSFSQNVELLNL 59
Query: 61 ITRRGPQAFTMLLEALRE--MGHWD----------------LVRDLDPNSPLQLRARRPV 102
+ +RGPQAF EALRE GH + L D D + P + P+
Sbjct: 60 LPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPL 119
Query: 103 LPPTRQGSDAXXXXXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQL-YRTRSRKRGVLV 161
R +D N PV C VK T F QL YR +SR RG+ +
Sbjct: 120 YKKLRLSTDTVEHSLD-NKDGPV---CLQVKPCTPEF---YQTHFQLAYRLQSRPRGLAL 172
Query: 162 VFSYISFLLNIEPN-RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLA 220
V S + F E R G +VD L LF +G++V + T ++ + L+ + + A
Sbjct: 173 VLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPA 232
Query: 221 GY--ECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIF 278
+ + + SHG E I DGK + L + F+N P+ + PK+F
Sbjct: 233 HRVTDSCIVALLSHGVEGA------IYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFI 286
Query: 279 QACRG 283
QACRG
Sbjct: 287 QACRG 291
>AC073342-3|AAP22347.1| 312|Homo sapiens unknown protein.
Length = 312
Score = 76.2 bits (179), Expect = 2e-13
Identities = 83/305 (27%), Positives = 128/305 (41%), Gaps = 36/305 (11%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M H++ +++N L + L ++ L EK + + +M E + + + L
Sbjct: 1 MHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQ-AKVGSFSQNVELLNL 59
Query: 61 ITRRGPQAFTMLLEALRE--MGHWD----------------LVRDLDPNSPLQLRARRPV 102
+ +RGPQAF EALRE GH + L D D + P + P+
Sbjct: 60 LPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPL 119
Query: 103 LPPTRQGSDAXXXXXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQL-YRTRSRKRGVLV 161
R +D N PV C VK T F QL YR +SR RG+ +
Sbjct: 120 YKKLRLSTDTVEHSLD-NKDGPV---CLQVKPCTPEF---YQTHFQLAYRLQSRPRGLAL 172
Query: 162 VFSYISFLLNIEPN-RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSVLA 220
V S + F E R G +VD L LF +G++V + T ++ + L+ + + A
Sbjct: 173 VLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPA 232
Query: 221 GY--ECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIF 278
+ + + SHG E I DGK + L + F+N P+ + PK+F
Sbjct: 233 HRVTDSCIVALLSHGVEGA------IYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFI 286
Query: 279 QACRG 283
QACRG
Sbjct: 287 QACRG 291
>U86214-1|AAB46730.1| 521|Homo sapiens Fas-associated death domain
protein interleukin-1b-converting enzyme 2 protein.
Length = 521
Score = 74.5 bits (175), Expect = 6e-13
Identities = 55/213 (25%), Positives = 98/213 (46%), Gaps = 26/213 (12%)
Query: 149 LYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQT 208
+YR RG+ V+ + SF +++ +R G + D + L ++F +GF V + N+T +
Sbjct: 275 VYRMNRNHRGLCVIVNNHSFT-SLK-DRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 332
Query: 209 RATLEQM--SSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKL 266
L++ + A +C + +HG R+ + + SD I + I+ +F +
Sbjct: 333 EMVLQKQKCNPAHADGDCFVFCILTHG---RFGA---VYSSDEALIPIREIMSHFTALQC 386
Query: 267 PNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEK 326
P + PK+F QAC+GE + P+ + D
Sbjct: 387 PRLAEKPKLFFIQACQGEE---------IQPSVSIEAD-------ALNPEQAPTSLQDSI 430
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLC 359
P ++ L+ +T+PG++S R V+ GSWYIQ LC
Sbjct: 431 PAEADFLLGLATVPGYVSFRHVEEGSWYIQSLC 463
>U60519-1|AAC50644.1| 479|Homo sapiens apoptotic cysteine protease
Mch4 protein.
Length = 479
Score = 74.5 bits (175), Expect = 6e-13
Identities = 55/213 (25%), Positives = 98/213 (46%), Gaps = 26/213 (12%)
Query: 149 LYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQT 208
+YR RG+ V+ + SF +++ +R G + D + L ++F +GF V + N+T +
Sbjct: 232 VYRMNRNHRGLCVIVNNHSFT-SLK-DRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 289
Query: 209 RATLEQM--SSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKL 266
L++ + A +C + +HG R+ + + SD I + I+ +F +
Sbjct: 290 EMVLQKQKCNPAHADGDCFVFCILTHG---RFGA---VYSSDEALIPIREIMSHFTALQC 343
Query: 267 PNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEK 326
P + PK+F QAC+GE + P+ + D
Sbjct: 344 PRLAEKPKLFFIQACQGEE---------IQPSVSIEAD-------ALNPEQAPTSLQDSI 387
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLC 359
P ++ L+ +T+PG++S R V+ GSWYIQ LC
Sbjct: 388 PAEADFLLGLATVPGYVSFRHVEEGSWYIQSLC 420
>EF050529-1|ABJ53426.1| 522|Homo sapiens caspase 10,
apoptosis-related cysteine peptidase protein.
Length = 522
Score = 74.5 bits (175), Expect = 6e-13
Identities = 55/213 (25%), Positives = 98/213 (46%), Gaps = 26/213 (12%)
Query: 149 LYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQT 208
+YR RG+ V+ + SF +++ +R G + D + L ++F +GF V + N+T +
Sbjct: 275 VYRMNRNHRGLCVIVNNHSFT-SLK-DRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 332
Query: 209 RATLEQM--SSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKL 266
L++ + A +C + +HG R+ + + SD I + I+ +F +
Sbjct: 333 EMVLQKQKCNPAHADGDCFVFCILTHG---RFGA---VYSSDEALIPIREIMSHFTALQC 386
Query: 267 PNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEK 326
P + PK+F QAC+GE + P+ + D
Sbjct: 387 PRLAEKPKLFFIQACQGEE---------IQPSVSIEAD-------ALNPEQAPTSLQDSI 430
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLC 359
P ++ L+ +T+PG++S R V+ GSWYIQ LC
Sbjct: 431 PAEADFLLGLATVPGYVSFRHVEEGSWYIQSLC 463
>BC042844-1|AAH42844.1| 522|Homo sapiens CASP10 protein protein.
Length = 522
Score = 74.5 bits (175), Expect = 6e-13
Identities = 55/213 (25%), Positives = 98/213 (46%), Gaps = 26/213 (12%)
Query: 149 LYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQT 208
+YR RG+ V+ + SF +++ +R G + D + L ++F +GF V + N+T +
Sbjct: 275 VYRMNRNHRGLCVIVNNHSFT-SLK-DRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 332
Query: 209 RATLEQM--SSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKL 266
L++ + A +C + +HG R+ + + SD I + I+ +F +
Sbjct: 333 EMVLQKQKCNPAHADGDCFVFCILTHG---RFGA---VYSSDEALIPIREIMSHFTALQC 386
Query: 267 PNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEK 326
P + PK+F QAC+GE + P+ + D
Sbjct: 387 PRLAEKPKLFFIQACQGEE---------IQPSVSIEAD-------ALNPEQAPTSLQDSI 430
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLC 359
P ++ L+ +T+PG++S R V+ GSWYIQ LC
Sbjct: 431 PAEADFLLGLATVPGYVSFRHVEEGSWYIQSLC 463
>AJ487679-1|CAD32372.1| 478|Homo sapiens caspase 10 protein.
Length = 478
Score = 74.5 bits (175), Expect = 6e-13
Identities = 55/213 (25%), Positives = 98/213 (46%), Gaps = 26/213 (12%)
Query: 149 LYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQT 208
+YR RG+ V+ + SF +++ +R G + D + L ++F +GF V + N+T +
Sbjct: 232 VYRMNRNHRGLCVIVNNHSFT-SLK-DRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 289
Query: 209 RATLEQM--SSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKL 266
L++ + A +C + +HG R+ + + SD I + I+ +F +
Sbjct: 290 EMVLQKQKCNPAHADGDCFVFCILTHG---RFGA---VYSSDEALIPIREIMSHFTALQC 343
Query: 267 PNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEK 326
P + PK+F QAC+GE + P+ + D
Sbjct: 344 PRLAEKPKLFFIQACQGEE---------IQPSVSIEAD-------ALNPEQAPTSLQDSI 387
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLC 359
P ++ L+ +T+PG++S R V+ GSWYIQ LC
Sbjct: 388 PAEADFLLGLATVPGYVSFRHVEEGSWYIQSLC 420
>AC007283-1|AAY24291.1| 522|Homo sapiens unknown protein.
Length = 522
Score = 74.5 bits (175), Expect = 6e-13
Identities = 55/213 (25%), Positives = 98/213 (46%), Gaps = 26/213 (12%)
Query: 149 LYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQT 208
+YR RG+ V+ + SF +++ +R G + D + L ++F +GF V + N+T +
Sbjct: 275 VYRMNRNHRGLCVIVNNHSFT-SLK-DRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 332
Query: 209 RATLEQM--SSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKL 266
L++ + A +C + +HG R+ + + SD I + I+ +F +
Sbjct: 333 EMVLQKQKCNPAHADGDCFVFCILTHG---RFGA---VYSSDEALIPIREIMSHFTALQC 386
Query: 267 PNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEK 326
P + PK+F QAC+GE + P+ + D
Sbjct: 387 PRLAEKPKLFFIQACQGEE---------IQPSVSIEAD-------ALNPEQAPTSLQDSI 430
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLC 359
P ++ L+ +T+PG++S R V+ GSWYIQ LC
Sbjct: 431 PAEADFLLGLATVPGYVSFRHVEEGSWYIQSLC 463
>AB038979-2|BAB32553.1| 479|Homo sapiens caspase-10a protein.
Length = 479
Score = 74.5 bits (175), Expect = 6e-13
Identities = 55/213 (25%), Positives = 98/213 (46%), Gaps = 26/213 (12%)
Query: 149 LYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQT 208
+YR RG+ V+ + SF +++ +R G + D + L ++F +GF V + N+T +
Sbjct: 232 VYRMNRNHRGLCVIVNNHSFT-SLK-DRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 289
Query: 209 RATLEQM--SSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKL 266
L++ + A +C + +HG R+ + + SD I + I+ +F +
Sbjct: 290 EMVLQKQKCNPAHADGDCFVFCILTHG---RFGA---VYSSDEALIPIREIMSHFTALQC 343
Query: 267 PNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEK 326
P + PK+F QAC+GE + P+ + D
Sbjct: 344 PRLAEKPKLFFIQACQGEE---------IQPSVSIEAD-------ALNPEQAPTSLQDSI 387
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLC 359
P ++ L+ +T+PG++S R V+ GSWYIQ LC
Sbjct: 388 PAEADFLLGLATVPGYVSFRHVEEGSWYIQSLC 420
>AB038979-1|BAB32554.1| 521|Homo sapiens caspase-10b protein.
Length = 521
Score = 74.5 bits (175), Expect = 6e-13
Identities = 55/213 (25%), Positives = 98/213 (46%), Gaps = 26/213 (12%)
Query: 149 LYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQT 208
+YR RG+ V+ + SF +++ +R G + D + L ++F +GF V + N+T +
Sbjct: 275 VYRMNRNHRGLCVIVNNHSFT-SLK-DRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 332
Query: 209 RATLEQM--SSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKL 266
L++ + A +C + +HG R+ + + SD I + I+ +F +
Sbjct: 333 EMVLQKQKCNPAHADGDCFVFCILTHG---RFGA---VYSSDEALIPIREIMSHFTALQC 386
Query: 267 PNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEK 326
P + PK+F QAC+GE + P+ + D
Sbjct: 387 PRLAEKPKLFFIQACQGEE---------IQPSVSIEAD-------ALNPEQAPTSLQDSI 430
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLC 359
P ++ L+ +T+PG++S R V+ GSWYIQ LC
Sbjct: 431 PAEADFLLGLATVPGYVSFRHVEEGSWYIQSLC 463
>AF111345-1|AAD28403.1| 522|Homo sapiens caspase-10/d protein.
Length = 522
Score = 74.1 bits (174), Expect = 8e-13
Identities = 55/213 (25%), Positives = 98/213 (46%), Gaps = 26/213 (12%)
Query: 149 LYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQT 208
+YR RG+ V+ + SF +++ +R G + D + L ++F +GF V + N+T +
Sbjct: 275 VYRMNRNHRGLCVIVNNHSFT-SLK-DRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 332
Query: 209 RATLEQM--SSVLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKL 266
L++ + A +C + +HG R+ + + SD I + I+ +F +
Sbjct: 333 EMVLQKQKCNPAHADGDCFVFCILTHG---RFGA---VYSSDEALIPIREIMSHFTALQC 386
Query: 267 PNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEK 326
P + PK+F QAC+GE + P+ + D
Sbjct: 387 PRLAEKPKLFFIQACQGEE---------IQPSISIEAD-------ALNPEQAPTSLQDSI 430
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLC 359
P ++ L+ +T+PG++S R V+ GSWYIQ LC
Sbjct: 431 PAEADFLLGLATVPGYVSFRHVEEGSWYIQSLC 463
>U39613-1|AAC50346.1| 303|Homo sapiens ICE-LAP3 protein.
Length = 303
Score = 68.5 bits (160), Expect = 4e-11
Identities = 55/217 (25%), Positives = 92/217 (42%), Gaps = 28/217 (12%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGH 234
R+G + D + L F +GF+V+ Y + + + + L++ S C ++ SHG
Sbjct: 87 RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGE 146
Query: 235 ERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRG-ENEDFVQGGG 293
E I DG + + +F + + PK+F QACRG E +D +Q
Sbjct: 147 ENV------IYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDAIQ--- 196
Query: 294 ALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSW 353
A G + P+ ++ L A ST+PG+ S R GSW
Sbjct: 197 --------ADSGPINDTDANPRYKI--------PVEADFLFAYSTVPGYYSWRSPGRGSW 240
Query: 354 YIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGRQT 390
++Q LC + E D + ++ T V+ R+ F Q+
Sbjct: 241 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQS 277
>U67320-1|AAC51153.1| 303|Homo sapiens Lice2 gamma cysteine
protease protein.
Length = 303
Score = 68.1 bits (159), Expect = 5e-11
Identities = 55/217 (25%), Positives = 92/217 (42%), Gaps = 28/217 (12%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGH 234
R+G + D + L F +GF+V+ Y + + + + L++ S C ++ SHG
Sbjct: 87 RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGE 146
Query: 235 ERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRG-ENEDFVQGGG 293
E I DG + + +F + + PK+F QACRG E +D +Q
Sbjct: 147 ENV------IYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQ--- 196
Query: 294 ALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSW 353
A G + P+ ++ L A ST+PG+ S R GSW
Sbjct: 197 --------ADSGPINDTDANPRYKI--------PVEADFLFAYSTVPGYYSWRSPGRGSW 240
Query: 354 YIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGRQT 390
++Q LC + E D + ++ T V+ R+ F Q+
Sbjct: 241 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQS 277
>U67319-1|AAC51152.1| 336|Homo sapiens Lice2 beta cysteine protease
protein.
Length = 336
Score = 68.1 bits (159), Expect = 5e-11
Identities = 55/217 (25%), Positives = 92/217 (42%), Gaps = 28/217 (12%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGH 234
R+G + D + L F +GF+V+ Y + + + + L++ S C ++ SHG
Sbjct: 120 RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGE 179
Query: 235 ERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRG-ENEDFVQGGG 293
E I DG + + +F + + PK+F QACRG E +D +Q
Sbjct: 180 ENV------IYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQ--- 229
Query: 294 ALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSW 353
A G + P+ ++ L A ST+PG+ S R GSW
Sbjct: 230 --------ADSGPINDTDANPRYKI--------PVEADFLFAYSTVPGYYSWRSPGRGSW 273
Query: 354 YIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGRQT 390
++Q LC + E D + ++ T V+ R+ F Q+
Sbjct: 274 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQS 310
>U67206-1|AAF21460.1| 303|Homo sapiens Lice2 alpha protein.
Length = 303
Score = 68.1 bits (159), Expect = 5e-11
Identities = 55/217 (25%), Positives = 92/217 (42%), Gaps = 28/217 (12%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGH 234
R+G + D + L F +GF+V+ Y + + + + L++ S C ++ SHG
Sbjct: 87 RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGE 146
Query: 235 ERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRG-ENEDFVQGGG 293
E I DG + + +F + + PK+F QACRG E +D +Q
Sbjct: 147 ENV------IYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQ--- 196
Query: 294 ALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSW 353
A G + P+ ++ L A ST+PG+ S R GSW
Sbjct: 197 --------ADSGPINDTDANPRYKI--------PVEADFLFAYSTVPGYYSWRSPGRGSW 240
Query: 354 YIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGRQT 390
++Q LC + E D + ++ T V+ R+ F Q+
Sbjct: 241 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQS 277
>U40281-1|AAC50352.1| 303|Homo sapiens CMH-1 protein.
Length = 303
Score = 68.1 bits (159), Expect = 5e-11
Identities = 55/217 (25%), Positives = 92/217 (42%), Gaps = 28/217 (12%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGH 234
R+G + D + L F +GF+V+ Y + + + + L++ S C ++ SHG
Sbjct: 87 RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGE 146
Query: 235 ERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRG-ENEDFVQGGG 293
E I DG + + +F + + PK+F QACRG E +D +Q
Sbjct: 147 ENV------IYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQ--- 196
Query: 294 ALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSW 353
A G + P+ ++ L A ST+PG+ S R GSW
Sbjct: 197 --------ADSGPINDTDANPRYKI--------PVEADFLFAYSTVPGYYSWRSPGRGSW 240
Query: 354 YIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGRQT 390
++Q LC + E D + ++ T V+ R+ F Q+
Sbjct: 241 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQS 277
>U37448-1|AAC50303.1| 303|Homo sapiens Mch3 isoform alpha protein.
Length = 303
Score = 68.1 bits (159), Expect = 5e-11
Identities = 55/217 (25%), Positives = 92/217 (42%), Gaps = 28/217 (12%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGH 234
R+G + D + L F +GF+V+ Y + + + + L++ S C ++ SHG
Sbjct: 87 RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGE 146
Query: 235 ERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRG-ENEDFVQGGG 293
E I DG + + +F + + PK+F QACRG E +D +Q
Sbjct: 147 ENV------IYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQ--- 196
Query: 294 ALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSW 353
A G + P+ ++ L A ST+PG+ S R GSW
Sbjct: 197 --------ADSGPINDTDANPRYKI--------PVEADFLFAYSTVPGYYSWRSPGRGSW 240
Query: 354 YIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGRQT 390
++Q LC + E D + ++ T V+ R+ F Q+
Sbjct: 241 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQS 277
>BT006683-1|AAP35329.1| 303|Homo sapiens caspase 7,
apoptosis-related cysteine protease protein.
Length = 303
Score = 68.1 bits (159), Expect = 5e-11
Identities = 55/217 (25%), Positives = 92/217 (42%), Gaps = 28/217 (12%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGH 234
R+G + D + L F +GF+V+ Y + + + + L++ S C ++ SHG
Sbjct: 87 RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGE 146
Query: 235 ERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRG-ENEDFVQGGG 293
E I DG + + +F + + PK+F QACRG E +D +Q
Sbjct: 147 ENV------IYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQ--- 196
Query: 294 ALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSW 353
A G + P+ ++ L A ST+PG+ S R GSW
Sbjct: 197 --------ADSGPINDTDANPRYKI--------PVEADFLFAYSTVPGYYSWRSPGRGSW 240
Query: 354 YIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGRQT 390
++Q LC + E D + ++ T V+ R+ F Q+
Sbjct: 241 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQS 277
>BC015799-1|AAH15799.1| 303|Homo sapiens caspase 7,
apoptosis-related cysteine peptidase protein.
Length = 303
Score = 68.1 bits (159), Expect = 5e-11
Identities = 55/217 (25%), Positives = 92/217 (42%), Gaps = 28/217 (12%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGH 234
R+G + D + L F +GF+V+ Y + + + + L++ S C ++ SHG
Sbjct: 87 RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGE 146
Query: 235 ERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRG-ENEDFVQGGG 293
E I DG + + +F + + PK+F QACRG E +D +Q
Sbjct: 147 ENV------IYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQ--- 196
Query: 294 ALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSW 353
A G + P+ ++ L A ST+PG+ S R GSW
Sbjct: 197 --------ADSGPINDTDANPRYKI--------PVEADFLFAYSTVPGYYSWRSPGRGSW 240
Query: 354 YIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGRQT 390
++Q LC + E D + ++ T V+ R+ F Q+
Sbjct: 241 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQS 277
>AL627395-1|CAI16004.1| 303|Homo sapiens caspase 7,
apoptosis-related cysteine peptidase protein.
Length = 303
Score = 68.1 bits (159), Expect = 5e-11
Identities = 55/217 (25%), Positives = 92/217 (42%), Gaps = 28/217 (12%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGH 234
R+G + D + L F +GF+V+ Y + + + + L++ S C ++ SHG
Sbjct: 87 RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGE 146
Query: 235 ERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRG-ENEDFVQGGG 293
E I DG + + +F + + PK+F QACRG E +D +Q
Sbjct: 147 ENV------IYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQ--- 196
Query: 294 ALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSW 353
A G + P+ ++ L A ST+PG+ S R GSW
Sbjct: 197 --------ADSGPINDTDANPRYKI--------PVEADFLFAYSTVPGYYSWRSPGRGSW 240
Query: 354 YIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGRQT 390
++Q LC + E D + ++ T V+ R+ F Q+
Sbjct: 241 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQS 277
>AL592546-4|CAI12638.1| 303|Homo sapiens caspase 7,
apoptosis-related cysteine peptidase protein.
Length = 303
Score = 68.1 bits (159), Expect = 5e-11
Identities = 55/217 (25%), Positives = 92/217 (42%), Gaps = 28/217 (12%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGH 234
R+G + D + L F +GF+V+ Y + + + + L++ S C ++ SHG
Sbjct: 87 RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGE 146
Query: 235 ERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRG-ENEDFVQGGG 293
E I DG + + +F + + PK+F QACRG E +D +Q
Sbjct: 147 ENV------IYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQ--- 196
Query: 294 ALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSW 353
A G + P+ ++ L A ST+PG+ S R GSW
Sbjct: 197 --------ADSGPINDTDANPRYKI--------PVEADFLFAYSTVPGYYSWRSPGRGSW 240
Query: 354 YIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGRQT 390
++Q LC + E D + ++ T V+ R+ F Q+
Sbjct: 241 FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQS 277
>AF078533-1|AAC28380.1| 377|Homo sapiens evolutionarily related
interleukin-1beta converting enzyme protein.
Length = 377
Score = 67.7 bits (158), Expect = 7e-11
Identities = 67/263 (25%), Positives = 104/263 (39%), Gaps = 13/263 (4%)
Query: 148 QLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQ 207
++Y + RK + + + P R+G +D +K L +G+ V + LT
Sbjct: 124 EIYPIKERKDRTRLALIICNTEFDHMPPRNGAALDILGMKQLLEGLGYTVEVEEKLTARD 183
Query: 208 TRATLEQMSS--VLAGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRK 265
+ L + ++ + FLV SHG + + I FNNR
Sbjct: 184 MESVLWKFAAREEHKSSDSTFLVFMSHGILDGICGTMHSE-EEPDVLPYDTIFRTFNNRN 242
Query: 266 LPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXE 325
+ D PKV I QACRG N +G ++ +P D + E
Sbjct: 243 CLSLKDKPKVIIVQACRGAN----RGELWVSDSPPALAD-SFSQSSENLEEDAVYKTHVE 297
Query: 326 KPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRL-RL 384
K I +ST P +S RD+K GS +I L F + A CH++E+F V + +
Sbjct: 298 KDF---IAFCSST-PHNVSWRDIKKGSLFITRLITCFQKYAWCCHLEEVFRKVQQSFEKP 353
Query: 385 RFGRQTSSVDRWGFNNKLYLHPG 407
Q +V+R YL PG
Sbjct: 354 NVKAQMPTVERLSMTRYFYLFPG 376
>Z48810-1|CAA88750.1| 377|Homo sapiens TX protease precursor
protein.
Length = 377
Score = 65.7 bits (153), Expect = 3e-10
Identities = 67/239 (28%), Positives = 99/239 (41%), Gaps = 17/239 (7%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R+G + D +K L + + V +NLT + L ++ + FLV+ S
Sbjct: 150 PPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMS 209
Query: 232 HGH-ERRYSSDTDIRCSDGKFISLY-AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFV 289
HG E + D + D + LY I FNNR + D PKV I QACRG N
Sbjct: 210 HGILEGICGTVHDEKKPD---VLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGAN---- 262
Query: 290 QGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVK 349
+G + +P + + A EK I +ST P +S RD
Sbjct: 263 RGELWVRDSP-ASLEVASSQSSENLEEDAVYKTHVEKDF---IAFCSST-PHNVSWRDST 317
Query: 350 AGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRL-RFGRQTSSVDRWGFNNKLYLHPG 407
GS +I L F + + CH++E+F V + R Q +++R YL PG
Sbjct: 318 MGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPG 376
>U28979-2|AAC99854.1| 286|Homo sapiens Mih1/TX isoform delta
protein.
Length = 286
Score = 65.7 bits (153), Expect = 3e-10
Identities = 67/239 (28%), Positives = 99/239 (41%), Gaps = 17/239 (7%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R+G + D +K L + + V +NLT + L ++ + FLV+ S
Sbjct: 59 PPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMS 118
Query: 232 HGH-ERRYSSDTDIRCSDGKFISLY-AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFV 289
HG E + D + D + LY I FNNR + D PKV I QACRG N
Sbjct: 119 HGILEGICGTVHDEKKPD---VLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGAN---- 171
Query: 290 QGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVK 349
+G + +P + + A EK I +ST P +S RD
Sbjct: 172 RGELWVRDSP-ASLEVASSQSSENLEEDAVYKTHVEKDF---IAFCSST-PHNVSWRDST 226
Query: 350 AGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRL-RFGRQTSSVDRWGFNNKLYLHPG 407
GS +I L F + + CH++E+F V + R Q +++R YL PG
Sbjct: 227 MGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPG 285
>U28978-1|AAC99852.1| 321|Homo sapiens Mih1/TX isoform gamma
protein.
Length = 321
Score = 65.7 bits (153), Expect = 3e-10
Identities = 67/239 (28%), Positives = 99/239 (41%), Gaps = 17/239 (7%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R+G + D +K L + + V +NLT + L ++ + FLV+ S
Sbjct: 94 PPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMS 153
Query: 232 HGH-ERRYSSDTDIRCSDGKFISLY-AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFV 289
HG E + D + D + LY I FNNR + D PKV I QACRG N
Sbjct: 154 HGILEGICGTVHDEKKPD---VLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGAN---- 206
Query: 290 QGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVK 349
+G + +P + + A EK I +ST P +S RD
Sbjct: 207 RGELWVRDSP-ASLEVASSQSSENLEEDAVYKTHVEKDF---IAFCSST-PHNVSWRDST 261
Query: 350 AGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRL-RFGRQTSSVDRWGFNNKLYLHPG 407
GS +I L F + + CH++E+F V + R Q +++R YL PG
Sbjct: 262 MGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPG 320
>U28977-1|AAC99851.1| 331|Homo sapiens Mih1/TX isoform beta
protein.
Length = 331
Score = 65.7 bits (153), Expect = 3e-10
Identities = 67/239 (28%), Positives = 99/239 (41%), Gaps = 17/239 (7%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R+G + D +K L + + V +NLT + L ++ + FLV+ S
Sbjct: 104 PPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMS 163
Query: 232 HGH-ERRYSSDTDIRCSDGKFISLY-AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFV 289
HG E + D + D + LY I FNNR + D PKV I QACRG N
Sbjct: 164 HGILEGICGTVHDEKKPD---VLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGAN---- 216
Query: 290 QGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVK 349
+G + +P + + A EK I +ST P +S RD
Sbjct: 217 RGELWVRDSP-ASLEVASSQSSENLEEDAVYKTHVEKDF---IAFCSST-PHNVSWRDST 271
Query: 350 AGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRL-RFGRQTSSVDRWGFNNKLYLHPG 407
GS +I L F + + CH++E+F V + R Q +++R YL PG
Sbjct: 272 MGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPG 330
>U28976-1|AAC99850.1| 377|Homo sapiens Mih1/TX isoform alpha
protein.
Length = 377
Score = 65.7 bits (153), Expect = 3e-10
Identities = 67/239 (28%), Positives = 99/239 (41%), Gaps = 17/239 (7%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R+G + D +K L + + V +NLT + L ++ + FLV+ S
Sbjct: 150 PPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMS 209
Query: 232 HGH-ERRYSSDTDIRCSDGKFISLY-AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFV 289
HG E + D + D + LY I FNNR + D PKV I QACRG N
Sbjct: 210 HGILEGICGTVHDEKKPD---VLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGAN---- 262
Query: 290 QGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVK 349
+G + +P + + A EK I +ST P +S RD
Sbjct: 263 RGELWVRDSP-ASLEVASSQSSENLEEDAVYKTHVEKDF---IAFCSST-PHNVSWRDST 317
Query: 350 AGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRL-RFGRQTSSVDRWGFNNKLYLHPG 407
GS +I L F + + CH++E+F V + R Q +++R YL PG
Sbjct: 318 MGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPG 376
>U28015-1|AAA75172.1| 418|Homo sapiens cysteine protease protein.
Length = 418
Score = 65.7 bits (153), Expect = 3e-10
Identities = 64/238 (26%), Positives = 94/238 (39%), Gaps = 15/238 (6%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R+G + D +K L +G+ V+ +NLT + L ++ + FLV+ S
Sbjct: 191 PARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMS 250
Query: 232 HGHERRYSSDTDIRCSDGKFISLY-AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
HG + + LY I FNNR + D PKV I QACRGE
Sbjct: 251 HGILEGICGTAHKKKKPD--VLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKH---- 304
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
G L A + E+ + I +ST P +S RD
Sbjct: 305 --GELWVRDSPASLAVISSQSSENLEADSVCKIHEEKDF--IAFCSST-PHNVSWRDRTR 359
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGR-QTSSVDRWGFNNKLYLHPG 407
GS +I L F + + CH+ E+F V K + + Q +++R YL PG
Sbjct: 360 GSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPG 417
>U28014-1|AAA75171.1| 377|Homo sapiens cysteine protease protein.
Length = 377
Score = 65.7 bits (153), Expect = 3e-10
Identities = 67/239 (28%), Positives = 99/239 (41%), Gaps = 17/239 (7%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R+G + D +K L + + V +NLT + L ++ + FLV+ S
Sbjct: 150 PPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMS 209
Query: 232 HGH-ERRYSSDTDIRCSDGKFISLY-AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFV 289
HG E + D + D + LY I FNNR + D PKV I QACRG N
Sbjct: 210 HGILEGICGTVHDEKKPD---VLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGAN---- 262
Query: 290 QGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVK 349
+G + +P + + A EK I +ST P +S RD
Sbjct: 263 RGELWVRDSP-ASLEVASSQSSENLEEDAVYKTHVEKDF---IAFCSST-PHNVSWRDST 317
Query: 350 AGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRL-RFGRQTSSVDRWGFNNKLYLHPG 407
GS +I L F + + CH++E+F V + R Q +++R YL PG
Sbjct: 318 MGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPG 376
>U25804-1|AAA86890.1| 377|Homo sapiens Ich-2 protein.
Length = 377
Score = 65.7 bits (153), Expect = 3e-10
Identities = 67/239 (28%), Positives = 99/239 (41%), Gaps = 17/239 (7%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R+G + D +K L + + V +NLT + L ++ + FLV+ S
Sbjct: 150 PPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMS 209
Query: 232 HGH-ERRYSSDTDIRCSDGKFISLY-AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFV 289
HG E + D + D + LY I FNNR + D PKV I QACRG N
Sbjct: 210 HGILEGICGTVHDEKKPD---VLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGAN---- 262
Query: 290 QGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVK 349
+G + +P + + A EK I +ST P +S RD
Sbjct: 263 RGELWVRDSP-ASLEVASSQSSENLEEDAVYKTHVEKDF---IAFCSST-PHNVSWRDST 317
Query: 350 AGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRL-RFGRQTSSVDRWGFNNKLYLHPG 407
GS +I L F + + CH++E+F V + R Q +++R YL PG
Sbjct: 318 MGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPG 376
>DQ508420-1|ABF47103.1| 418|Homo sapiens caspase 5,
apoptosis-related cysteine peptidase protein.
Length = 418
Score = 65.7 bits (153), Expect = 3e-10
Identities = 64/238 (26%), Positives = 94/238 (39%), Gaps = 15/238 (6%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R+G + D +K L +G+ V+ +NLT + L ++ + FLV+ S
Sbjct: 191 PARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMS 250
Query: 232 HGHERRYSSDTDIRCSDGKFISLY-AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
HG + + LY I FNNR + D PKV I QACRGE
Sbjct: 251 HGILEGICGTAHKKKKPD--VLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKH---- 304
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
G L A + E+ + I +ST P +S RD
Sbjct: 305 --GELWVRDSPASLAVISSQSSENLEADSVCKIHEEKDF--IAFCSST-PHNVSWRDRTR 359
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGR-QTSSVDRWGFNNKLYLHPG 407
GS +I L F + + CH+ E+F V K + + Q +++R YL PG
Sbjct: 360 GSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPG 417
>DQ228677-1|ABB58703.1| 447|Homo sapiens caspase-5/f protein.
Length = 447
Score = 65.7 bits (153), Expect = 3e-10
Identities = 64/238 (26%), Positives = 94/238 (39%), Gaps = 15/238 (6%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R+G + D +K L +G+ V+ +NLT + L ++ + FLV+ S
Sbjct: 220 PARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMS 279
Query: 232 HGHERRYSSDTDIRCSDGKFISLY-AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
HG + + LY I FNNR + D PKV I QACRGE
Sbjct: 280 HGILEGICGTAHKKKKPD--VLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKH---- 333
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
G L A + E+ + I +ST P +S RD
Sbjct: 334 --GELWVRDSPASLAVISSQSSENLEADSVCKIHEEKDF--IAFCSST-PHNVSWRDRTR 388
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGR-QTSSVDRWGFNNKLYLHPG 407
GS +I L F + + CH+ E+F V K + + Q +++R YL PG
Sbjct: 389 GSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPG 446
>DQ228674-1|ABB58700.1| 292|Homo sapiens caspase-5/c protein.
Length = 292
Score = 65.7 bits (153), Expect = 3e-10
Identities = 64/238 (26%), Positives = 94/238 (39%), Gaps = 15/238 (6%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R+G + D +K L +G+ V+ +NLT + L ++ + FLV+ S
Sbjct: 65 PARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMS 124
Query: 232 HGHERRYSSDTDIRCSDGKFISLY-AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
HG + + LY I FNNR + D PKV I QACRGE
Sbjct: 125 HGILEGICGTAHKKKKPD--VLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKH---- 178
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
G L A + E+ + I +ST P +S RD
Sbjct: 179 --GELWVRDSPASLAVISSQSSENLEADSVCKIHEEKDF--IAFCSST-PHNVSWRDRTR 233
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGR-QTSSVDRWGFNNKLYLHPG 407
GS +I L F + + CH+ E+F V K + + Q +++R YL PG
Sbjct: 234 GSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPG 291
>DQ228673-1|ABB58699.1| 376|Homo sapiens caspase-5/b protein.
Length = 376
Score = 65.7 bits (153), Expect = 3e-10
Identities = 64/238 (26%), Positives = 94/238 (39%), Gaps = 15/238 (6%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R+G + D +K L +G+ V+ +NLT + L ++ + FLV+ S
Sbjct: 149 PARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMS 208
Query: 232 HGHERRYSSDTDIRCSDGKFISLY-AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
HG + + LY I FNNR + D PKV I QACRGE
Sbjct: 209 HGILEGICGTAHKKKKPD--VLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKH---- 262
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
G L A + E+ + I +ST P +S RD
Sbjct: 263 --GELWVRDSPASLAVISSQSSENLEADSVCKIHEEKDF--IAFCSST-PHNVSWRDRTR 317
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGR-QTSSVDRWGFNNKLYLHPG 407
GS +I L F + + CH+ E+F V K + + Q +++R YL PG
Sbjct: 318 GSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPG 375
>DQ228672-1|ABB58698.1| 434|Homo sapiens caspase-5/a protein.
Length = 434
Score = 65.7 bits (153), Expect = 3e-10
Identities = 64/238 (26%), Positives = 94/238 (39%), Gaps = 15/238 (6%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R+G + D +K L +G+ V+ +NLT + L ++ + FLV+ S
Sbjct: 207 PARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMS 266
Query: 232 HGHERRYSSDTDIRCSDGKFISLY-AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
HG + + LY I FNNR + D PKV I QACRGE
Sbjct: 267 HGILEGICGTAHKKKKPD--VLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKH---- 320
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
G L A + E+ + I +ST P +S RD
Sbjct: 321 --GELWVRDSPASLAVISSQSSENLEADSVCKIHEEKDF--IAFCSST-PHNVSWRDRTR 375
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGR-QTSSVDRWGFNNKLYLHPG 407
GS +I L F + + CH+ E+F V K + + Q +++R YL PG
Sbjct: 376 GSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPG 433
>BC017839-1|AAH17839.1| 377|Homo sapiens caspase 4,
apoptosis-related cysteine peptidase protein.
Length = 377
Score = 65.7 bits (153), Expect = 3e-10
Identities = 67/239 (28%), Positives = 99/239 (41%), Gaps = 17/239 (7%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R+G + D +K L + + V +NLT + L ++ + FLV+ S
Sbjct: 150 PPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMS 209
Query: 232 HGH-ERRYSSDTDIRCSDGKFISLY-AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFV 289
HG E + D + D + LY I FNNR + D PKV I QACRG N
Sbjct: 210 HGILEGICGTVHDEKKPD---VLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGAN---- 262
Query: 290 QGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVK 349
+G + +P + + A EK I +ST P +S RD
Sbjct: 263 RGELWVRDSP-ASLEVASSQSSENLEEDAVYKTHVEKDF---IAFCSST-PHNVSWRDST 317
Query: 350 AGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRL-RFGRQTSSVDRWGFNNKLYLHPG 407
GS +I L F + + CH++E+F V + R Q +++R YL PG
Sbjct: 318 MGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPG 376
>X98173-1|CAA66854.1| 464|Homo sapiens MACH-alpha-2 protein.
Length = 464
Score = 65.3 bits (152), Expect = 4e-10
Identities = 56/236 (23%), Positives = 105/236 (44%), Gaps = 28/236 (11%)
Query: 140 EDDVSRDI-QLYRTRSRKRGVLVVFSYISFL--------LNIEPNRDGVNVDCDKLKYLF 190
+D S+ + ++Y+ +S+ RG ++ + +F L+ +R+G ++D L F
Sbjct: 200 QDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTF 259
Query: 191 SEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDG 249
E+ FE+ + + T+EQ L+ + + +C + SHG + I +DG
Sbjct: 260 EELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGI------IYGTDG 313
Query: 250 KFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXX 309
+ +Y + F K P+ PKVF QAC+G+N + +G P + +
Sbjct: 314 QEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDN--YQKG----IPVETDSEEQPYLE 367
Query: 310 XXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAER 365
P ++ L+ +T+ +S+R+ G+WYIQ LC+ ER
Sbjct: 368 MDLSSPQTRYI------PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER 417
>X98172-1|CAA66853.1| 479|Homo sapiens MACH-alpha-1 protein.
Length = 479
Score = 65.3 bits (152), Expect = 4e-10
Identities = 56/236 (23%), Positives = 105/236 (44%), Gaps = 28/236 (11%)
Query: 140 EDDVSRDI-QLYRTRSRKRGVLVVFSYISFL--------LNIEPNRDGVNVDCDKLKYLF 190
+D S+ + ++Y+ +S+ RG ++ + +F L+ +R+G ++D L F
Sbjct: 215 QDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTF 274
Query: 191 SEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDG 249
E+ FE+ + + T+EQ L+ + + +C + SHG + I +DG
Sbjct: 275 EELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGI------IYGTDG 328
Query: 250 KFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXX 309
+ +Y + F K P+ PKVF QAC+G+N + +G P + +
Sbjct: 329 QEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDN--YQKG----IPVETDSEEQPYLE 382
Query: 310 XXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAER 365
P ++ L+ +T+ +S+R+ G+WYIQ LC+ ER
Sbjct: 383 MDLSSPQTRYI------PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER 432
>X94993-1|CAA64450.1| 364|Homo sapiens TY protease protein.
Length = 364
Score = 65.3 bits (152), Expect = 4e-10
Identities = 64/238 (26%), Positives = 94/238 (39%), Gaps = 15/238 (6%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R+G + D +K L +G+ V+ +NLT + L ++ + FLV+ S
Sbjct: 137 PARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMS 196
Query: 232 HGHERRYSSDTDIRCSDGKFISLY-AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
HG + + LY I FNNR + D PKV I QACRGE
Sbjct: 197 HGILEGICGTAHKKKKPD--VLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKH---- 250
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
G L A + E+ + I +ST P +S RD
Sbjct: 251 --GELWVRDSPASLALISSQSSENLEADSVCKIHEEKDF--IAFCSST-PHNVSWRDRTR 305
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGR-QTSSVDRWGFNNKLYLHPG 407
GS +I L F + + CH+ E+F V K + + Q +++R YL PG
Sbjct: 306 GSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPG 363
>X65019-1|CAA46153.1| 404|Homo sapiens interleukin-1B converting
enzyme protein.
Length = 404
Score = 65.3 bits (152), Expect = 4e-10
Identities = 91/404 (22%), Positives = 153/404 (37%), Gaps = 27/404 (6%)
Query: 15 SLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYREITRRGPQAFTMLLE 74
S+ EGT ++ ++ L + V +++ +E + + T ++ R L + +G QA + +
Sbjct: 16 SMGEGT-INGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICIT 74
Query: 75 ALRE-----MGHWDLVRDLDPNSPLQLRARRPVLP--PTRQGSDAXXXXXXXNSSEPVAI 127
+ E G L D + L ++ + VL P Q + SE
Sbjct: 75 YICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVK 134
Query: 128 PCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLK 187
C ++++ ++ + + SR R L++ + + P R G VD +
Sbjct: 135 LC-SLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEE---FDSIPRRTGAEVDITGMT 190
Query: 188 YLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSSHG-HERRYSSDTDI 244
L +G+ V +NLT LE + + FLV SHG E
Sbjct: 191 MLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSE 250
Query: 245 RCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARD 304
+ D + L AI + N + P+ D PKV I QACRG++ V ++
Sbjct: 251 QVPD--ILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSV--------- 299
Query: 305 GAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAE 364
G + + + + S+ P +S R GS +I L E E
Sbjct: 300 GVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQE 359
Query: 365 RAHDCHVDELFTLVDKRLRLRFGR-QTSSVDRWGFNNKLYLHPG 407
A C V+E+F V GR Q + +R YL PG
Sbjct: 360 YACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPG 403
>U60520-1|AAC50645.1| 496|Homo sapiens apoptotic cysteine protease
Mch5 isoform alpha protein.
Length = 496
Score = 65.3 bits (152), Expect = 4e-10
Identities = 56/236 (23%), Positives = 105/236 (44%), Gaps = 28/236 (11%)
Query: 140 EDDVSRDI-QLYRTRSRKRGVLVVFSYISFL--------LNIEPNRDGVNVDCDKLKYLF 190
+D S+ + ++Y+ +S+ RG ++ + +F L+ +R+G ++D L F
Sbjct: 232 QDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTF 291
Query: 191 SEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDG 249
E+ FE+ + + T+EQ L+ + + +C + SHG + I +DG
Sbjct: 292 EELHFEIKPHHDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGI------IYGTDG 345
Query: 250 KFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXX 309
+ +Y + F K P+ PKVF QAC+G+N + +G P + +
Sbjct: 346 QEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDN--YQKG----IPVETDSEEQPYLE 399
Query: 310 XXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAER 365
P ++ L+ +T+ +S+R+ G+WYIQ LC+ ER
Sbjct: 400 MDLSSPQTRYI------PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER 449
>M87507-1|AAA66942.1| 404|Homo sapiens interleukin 1-beta
convertase protein.
Length = 404
Score = 65.3 bits (152), Expect = 4e-10
Identities = 91/404 (22%), Positives = 153/404 (37%), Gaps = 27/404 (6%)
Query: 15 SLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYREITRRGPQAFTMLLE 74
S+ EGT ++ ++ L + V +++ +E + + T ++ R L + +G QA + +
Sbjct: 16 SMGEGT-INGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICIT 74
Query: 75 ALRE-----MGHWDLVRDLDPNSPLQLRARRPVLP--PTRQGSDAXXXXXXXNSSEPVAI 127
+ E G L D + L ++ + VL P Q + SE
Sbjct: 75 YICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVK 134
Query: 128 PCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLK 187
C ++++ ++ + + SR R L++ + + P R G VD +
Sbjct: 135 LC-SLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEE---FDSIPRRTGAEVDITGMT 190
Query: 188 YLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSSHG-HERRYSSDTDI 244
L +G+ V +NLT LE + + FLV SHG E
Sbjct: 191 MLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSE 250
Query: 245 RCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARD 304
+ D + L AI + N + P+ D PKV I QACRG++ V ++
Sbjct: 251 QVPD--ILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSV--------- 299
Query: 305 GAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAE 364
G + + + + S+ P +S R GS +I L E E
Sbjct: 300 GVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQE 359
Query: 365 RAHDCHVDELFTLVDKRLRLRFGR-QTSSVDRWGFNNKLYLHPG 407
A C V+E+F V GR Q + +R YL PG
Sbjct: 360 YACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPG 403
>DQ355026-1|ABC67468.1| 496|Homo sapiens caspase 8,
apoptosis-related cysteine peptidase protein.
Length = 496
Score = 65.3 bits (152), Expect = 4e-10
Identities = 56/236 (23%), Positives = 105/236 (44%), Gaps = 28/236 (11%)
Query: 140 EDDVSRDI-QLYRTRSRKRGVLVVFSYISFL--------LNIEPNRDGVNVDCDKLKYLF 190
+D S+ + ++Y+ +S+ RG ++ + +F L+ +R+G ++D L F
Sbjct: 232 QDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTF 291
Query: 191 SEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDG 249
E+ FE+ + + T+EQ L+ + + +C + SHG + I +DG
Sbjct: 292 EELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGI------IYGTDG 345
Query: 250 KFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXX 309
+ +Y + F K P+ PKVF QAC+G+N + +G P + +
Sbjct: 346 QEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDN--YQKG----IPVETDSEEQPYLE 399
Query: 310 XXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAER 365
P ++ L+ +T+ +S+R+ G+WYIQ LC+ ER
Sbjct: 400 MDLSSPQTRYI------PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER 449
>BC113406-1|AAI13407.1| 418|Homo sapiens caspase 5,
apoptosis-related cysteine peptidase protein.
Length = 418
Score = 65.3 bits (152), Expect = 4e-10
Identities = 64/238 (26%), Positives = 94/238 (39%), Gaps = 15/238 (6%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R+G + D +K L +G+ V+ +NLT + L ++ + FLV+ S
Sbjct: 191 PARNGAHYDILGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMS 250
Query: 232 HGHERRYSSDTDIRCSDGKFISLY-AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
HG + + LY I FNNR + D PKV I QACRGE
Sbjct: 251 HGILEGICGTAHKKKKPD--VLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKH---- 304
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
G L A + E+ + I +ST P +S RD
Sbjct: 305 --GELWVRDSPASLAVISSQSSENLEADSVCKIHEEKDF--IAFCSST-PHNVSWRDRTR 359
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGR-QTSSVDRWGFNNKLYLHPG 407
GS +I L F + + CH+ E+F V K + + Q +++R YL PG
Sbjct: 360 GSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPG 417
>BC074994-1|AAH74994.1| 418|Homo sapiens caspase 5,
apoptosis-related cysteine peptidase protein.
Length = 418
Score = 65.3 bits (152), Expect = 4e-10
Identities = 64/238 (26%), Positives = 94/238 (39%), Gaps = 15/238 (6%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R+G + D +K L +G+ V+ +NLT + L ++ + FLV+ S
Sbjct: 191 PARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMS 250
Query: 232 HGHERRYSSDTDIRCSDGKFISLY-AIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
HG + + LY I FNNR + D PKV I QACRGE
Sbjct: 251 HGILEGICGTAHKKKKPD--VLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKH---- 304
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
G L A + E+ + I +ST P +S RD
Sbjct: 305 --GELWVRDSPASLALISSQSSENLEADSVCKIHEEKDF--IAFCSST-PHNVSWRDRTR 359
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGR-QTSSVDRWGFNNKLYLHPG 407
GS +I L F + + CH+ E+F V K + + Q +++R YL PG
Sbjct: 360 GSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPG 417
>AF422925-1|AAL87628.1| 538|Homo sapiens procaspase-8L protein.
Length = 538
Score = 65.3 bits (152), Expect = 4e-10
Identities = 56/236 (23%), Positives = 105/236 (44%), Gaps = 28/236 (11%)
Query: 140 EDDVSRDI-QLYRTRSRKRGVLVVFSYISFL--------LNIEPNRDGVNVDCDKLKYLF 190
+D S+ + ++Y+ +S+ RG ++ + +F L+ +R+G ++D L F
Sbjct: 274 QDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTF 333
Query: 191 SEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDG 249
E+ FE+ + + T+EQ L+ + + +C + SHG + I +DG
Sbjct: 334 EELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGI------IYGTDG 387
Query: 250 KFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXX 309
+ +Y + F K P+ PKVF QAC+G+N + +G P + +
Sbjct: 388 QEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDN--YQKG----IPVETDSEEQPYLE 441
Query: 310 XXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAER 365
P ++ L+ +T+ +S+R+ G+WYIQ LC+ ER
Sbjct: 442 MDLSSPQTRYI------PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER 491
>AF009620-1|AAB70913.1| 464|Homo sapiens apoptotic caspase
Mch5-beta protein.
Length = 464
Score = 65.3 bits (152), Expect = 4e-10
Identities = 56/236 (23%), Positives = 105/236 (44%), Gaps = 28/236 (11%)
Query: 140 EDDVSRDI-QLYRTRSRKRGVLVVFSYISFL--------LNIEPNRDGVNVDCDKLKYLF 190
+D S+ + ++Y+ +S+ RG ++ + +F L+ +R+G ++D L F
Sbjct: 200 QDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTF 259
Query: 191 SEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDG 249
E+ FE+ + + T+EQ L+ + + +C + SHG + I +DG
Sbjct: 260 EELHFEIKPHHDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGI------IYGTDG 313
Query: 250 KFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXX 309
+ +Y + F K P+ PKVF QAC+G+N + +G P + +
Sbjct: 314 QEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDN--YQKG----IPVETDSEEQPYLE 367
Query: 310 XXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAER 365
P ++ L+ +T+ +S+R+ G+WYIQ LC+ ER
Sbjct: 368 MDLSSPQTRYI------PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER 417
>AC007256-3|AAY24225.1| 496|Homo sapiens unknown protein.
Length = 496
Score = 65.3 bits (152), Expect = 4e-10
Identities = 56/236 (23%), Positives = 105/236 (44%), Gaps = 28/236 (11%)
Query: 140 EDDVSRDI-QLYRTRSRKRGVLVVFSYISFL--------LNIEPNRDGVNVDCDKLKYLF 190
+D S+ + ++Y+ +S+ RG ++ + +F L+ +R+G ++D L F
Sbjct: 232 QDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTF 291
Query: 191 SEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDG 249
E+ FE+ + + T+EQ L+ + + +C + SHG + I +DG
Sbjct: 292 EELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGI------IYGTDG 345
Query: 250 KFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXX 309
+ +Y + F K P+ PKVF QAC+G+N + +G P + +
Sbjct: 346 QEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDN--YQKG----IPVETDSEEQPYLE 399
Query: 310 XXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAER 365
P ++ L+ +T+ +S+R+ G+WYIQ LC+ ER
Sbjct: 400 MDLSSPQTRYI------PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER 449
>AB038985-1|BAB32555.1| 496|Homo sapiens caspase-8 protein.
Length = 496
Score = 65.3 bits (152), Expect = 4e-10
Identities = 56/236 (23%), Positives = 105/236 (44%), Gaps = 28/236 (11%)
Query: 140 EDDVSRDI-QLYRTRSRKRGVLVVFSYISFL--------LNIEPNRDGVNVDCDKLKYLF 190
+D S+ + ++Y+ +S+ RG ++ + +F L+ +R+G ++D L F
Sbjct: 232 QDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTF 291
Query: 191 SEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDG 249
E+ FE+ + + T+EQ L+ + + +C + SHG + I +DG
Sbjct: 292 EELHFEIKPHHDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGI------IYGTDG 345
Query: 250 KFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXX 309
+ +Y + F K P+ PKVF QAC+G+N + +G P + +
Sbjct: 346 QEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDN--YQKG----IPVETDSEEQPYLE 399
Query: 310 XXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAER 365
P ++ L+ +T+ +S+R+ G+WYIQ LC+ ER
Sbjct: 400 MDLSSPQTRYI------PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER 449
>U58143-1|AAC50602.1| 479|Homo sapiens FADD-homologous
ICE/CED-3-like protease protein.
Length = 479
Score = 64.5 bits (150), Expect = 6e-10
Identities = 56/236 (23%), Positives = 105/236 (44%), Gaps = 28/236 (11%)
Query: 140 EDDVSRDI-QLYRTRSRKRGVLVVFSYISFL--------LNIEPNRDGVNVDCDKLKYLF 190
+D S+ + ++Y+ +S+ RG ++ + +F L+ +R+G ++D L F
Sbjct: 215 QDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTF 274
Query: 191 SEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDG 249
E+ FE+ + + T+EQ L+ + + +C + SHG + I +DG
Sbjct: 275 EELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGI------IYGTDG 328
Query: 250 KFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXX 309
+ +Y + F K P+ PKVF QAC+G+N + +G P + +
Sbjct: 329 QEPPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDN--YQKG----IPVETDSEEQPYLE 382
Query: 310 XXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAER 365
P ++ L+ +T+ +S+R+ G+WYIQ LC+ ER
Sbjct: 383 MDLSSPQTRYI------PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER 432
>AL512883-5|CAI12972.1| 266|Homo sapiens caspase 9,
apoptosis-related cysteine peptidase protein.
Length = 266
Score = 64.1 bits (149), Expect = 9e-10
Identities = 38/114 (33%), Positives = 58/114 (50%), Gaps = 2/114 (1%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQ-TRATLEQMSSVLAGYECVFLVVSSHGH 234
R G N+DC+KL+ FS + F V +LT ++ A LE +C +V+ SHG
Sbjct: 97 RTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGC 156
Query: 235 ERRYSSDTD-IRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENED 287
+ + + +DG +S+ IV+ FN P+ PK+F QAC GE +D
Sbjct: 157 QASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKD 210
>AF102146-1|AAD24962.1| 479|Homo sapiens caspase 8 protein.
Length = 479
Score = 64.1 bits (149), Expect = 9e-10
Identities = 56/236 (23%), Positives = 105/236 (44%), Gaps = 28/236 (11%)
Query: 140 EDDVSRDI-QLYRTRSRKRGVLVVFSYISFL--------LNIEPNRDGVNVDCDKLKYLF 190
+D S+ + ++Y+ +S+ RG ++ + +F L+ +R+G ++D L F
Sbjct: 215 QDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTF 274
Query: 191 SEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDG 249
E+ FE+ + + T+EQ L+ + + +C + SHG + I +DG
Sbjct: 275 EELHFEIKPHDDCTVEQIYDILKIYQLMDHSNMDCFICCILSHGDKGI------IYGTDG 328
Query: 250 KFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXX 309
+ +Y + F K P+ PKVF QAC+G+N + +G P + +
Sbjct: 329 QEPPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDN--YQKG----IPVETDSEEQPYLE 382
Query: 310 XXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAER 365
P ++ L+ +T+ +S+R+ G+WYIQ LC+ ER
Sbjct: 383 MDLSSPQTRYI------PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER 432
>U26943-1|AAA74929.1| 277|Homo sapiens Yama protein protein.
Length = 277
Score = 62.5 bits (145), Expect = 3e-09
Identities = 59/216 (27%), Positives = 92/216 (42%), Gaps = 35/216 (16%)
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMS----SVLAGYECVFLVVS 230
+R G +VD L+ F + +EV +LT E+ + +S S + + CV L
Sbjct: 63 SRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLL--- 119
Query: 231 SHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
SHG E I ++G + L I ++F + + T PK+FI QACRG D
Sbjct: 120 SHGEEGI------IFGTNGP-VDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDC-- 170
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
+ D V P+ ++ L A ST PG+ S R+ K
Sbjct: 171 ---------GIETDSGVDDDMACHKI----------PVEADFLYAYSTAPGYYSWRNSKD 211
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRF 386
GSW+IQ LC + + A + T V++++ F
Sbjct: 212 GSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEF 247
>U13738-1|AAB60355.1| 277|Homo sapiens cysteine protease CPP32
isoform beta protein.
Length = 277
Score = 62.5 bits (145), Expect = 3e-09
Identities = 59/216 (27%), Positives = 92/216 (42%), Gaps = 35/216 (16%)
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMS----SVLAGYECVFLVVS 230
+R G +VD L+ F + +EV +LT E+ + +S S + + CV L
Sbjct: 63 SRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLL--- 119
Query: 231 SHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
SHG E I ++G + L I ++F + + T PK+FI QACRG D
Sbjct: 120 SHGEEGI------IFGTNGP-VDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDC-- 170
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
+ D V P+ ++ L A ST PG+ S R+ K
Sbjct: 171 ---------GIETDSGVDDDMACHKI----------PVEADFLYAYSTAPGYYSWRNSKD 211
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRF 386
GSW+IQ LC + + A + T V++++ F
Sbjct: 212 GSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEF 247
>U13697-1|AAC50107.1| 383|Homo sapiens Interleukin 1-beta
converting enzyme isoform beta protein.
Length = 383
Score = 62.5 bits (145), Expect = 3e-09
Identities = 90/397 (22%), Positives = 150/397 (37%), Gaps = 34/397 (8%)
Query: 15 SLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYREITRRGPQAFTMLLE 74
S+ EGT ++ ++ L + V +++ +E + + T ++ R L + +G QA + +
Sbjct: 16 SMGEGT-INGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICIT 74
Query: 75 ALREMGHWDLVRDLDPNSPLQLRARRPVLPPTRQGSDAXXXXXXXNSSEPVAIPCFHVKK 134
+ E + L L ++ Q P +P T GS+ ++ + +K
Sbjct: 75 YICEEDSY-LAGTLGLSAAPQAVQDNPAMP-TSSGSEGNVKLCSLEEAQRI-----WKQK 127
Query: 135 STHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIG 194
S + + SR R L++ + + P R G VD + L +G
Sbjct: 128 SAEIYP--------IMDKSSRTRLALIICNEE---FDSIPRRTGAEVDITGMTMLLQNLG 176
Query: 195 FEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSSHG-HERRYSSDTDIRCSDGKF 251
+ V +NLT LE + + FLV SHG E + D
Sbjct: 177 YSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPD--I 234
Query: 252 ISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXX 311
+ L AI + N + P+ D PKV I QACRG++ V ++ G
Sbjct: 235 LQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSV---------GVSGNLS 285
Query: 312 XXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHV 371
+ + + + S+ P +S R GS +I L E E A C V
Sbjct: 286 LPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDV 345
Query: 372 DELFTLVDKRLRLRFGR-QTSSVDRWGFNNKLYLHPG 407
+E+F V GR Q + +R YL PG
Sbjct: 346 EEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPG 382
>BC041689-1|AAH41689.1| 380|Homo sapiens CASP1 protein protein.
Length = 380
Score = 62.5 bits (145), Expect = 3e-09
Identities = 90/397 (22%), Positives = 150/397 (37%), Gaps = 34/397 (8%)
Query: 15 SLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYREITRRGPQAFTMLLE 74
S+ EGT ++ ++ L + V +++ +E + + T ++ R L + +G QA + +
Sbjct: 13 SMGEGT-INGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICIT 71
Query: 75 ALREMGHWDLVRDLDPNSPLQLRARRPVLPPTRQGSDAXXXXXXXNSSEPVAIPCFHVKK 134
+ E + L L ++ Q P +P T GS+ ++ + +K
Sbjct: 72 YICEEDSY-LAGTLGLSAAPQAVQDNPAMP-TSSGSEGNVKLCSLEEAQRI-----WKQK 124
Query: 135 STHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLKYLFSEIG 194
S + + SR R L++ + + P R G VD + L +G
Sbjct: 125 SAEIYP--------IMDKSSRTRLALIICNEE---FDSIPRRTGAEVDITGMTMLLQNLG 173
Query: 195 FEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSSHG-HERRYSSDTDIRCSDGKF 251
+ V +NLT LE + + FLV SHG E + D
Sbjct: 174 YSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPD--I 231
Query: 252 ISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVXXXX 311
+ L AI + N + P+ D PKV I QACRG++ V ++ G
Sbjct: 232 LQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSV---------GVSGNLS 282
Query: 312 XXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHV 371
+ + + + S+ P +S R GS +I L E E A C V
Sbjct: 283 LPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDV 342
Query: 372 DELFTLVDKRLRLRFGR-QTSSVDRWGFNNKLYLHPG 407
+E+F V GR Q + +R YL PG
Sbjct: 343 EEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPG 379
>BC016926-1|AAH16926.1| 277|Homo sapiens caspase 3,
apoptosis-related cysteine peptidase protein.
Length = 277
Score = 62.5 bits (145), Expect = 3e-09
Identities = 59/216 (27%), Positives = 92/216 (42%), Gaps = 35/216 (16%)
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMS----SVLAGYECVFLVVS 230
+R G +VD L+ F + +EV +LT E+ + +S S + + CV L
Sbjct: 63 SRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLL--- 119
Query: 231 SHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
SHG E I ++G + L I ++F + + T PK+FI QACRG D
Sbjct: 120 SHGEEGI------IFGTNGP-VDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDC-- 170
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
+ D V P+ ++ L A ST PG+ S R+ K
Sbjct: 171 ---------GIETDSGVDDDMACHKI----------PVEADFLYAYSTAPGYYSWRNSKD 211
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRF 386
GSW+IQ LC + + A + T V++++ F
Sbjct: 212 GSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEF 247
>AY219866-1|AAO25654.1| 277|Homo sapiens caspase 3,
apoptosis-related cysteine protease protein.
Length = 277
Score = 62.5 bits (145), Expect = 3e-09
Identities = 59/216 (27%), Positives = 92/216 (42%), Gaps = 35/216 (16%)
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMS----SVLAGYECVFLVVS 230
+R G +VD L+ F + +EV +LT E+ + +S S + + CV L
Sbjct: 63 SRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLL--- 119
Query: 231 SHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
SHG E I ++G + L I ++F + + T PK+FI QACRG D
Sbjct: 120 SHGEEGI------IFGTNGP-VDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDC-- 170
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
+ D V P+ ++ L A ST PG+ S R+ K
Sbjct: 171 ---------GIETDSGVDDDMACHKI----------PVEADFLYAYSTAPGYYSWRNSKD 211
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRF 386
GSW+IQ LC + + A + T V++++ F
Sbjct: 212 GSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEF 247
>AJ487678-1|CAD32371.1| 455|Homo sapiens caspase 10 protein.
Length = 455
Score = 62.5 bits (145), Expect = 3e-09
Identities = 45/176 (25%), Positives = 78/176 (44%), Gaps = 24/176 (13%)
Query: 186 LKYLFSEIGFEVLTYQNLTLEQTRATLEQM--SSVLAGYECVFLVVSSHGHERRYSSDTD 243
L ++F +GF V + N+T + L++ + A +C + +HG R+ +
Sbjct: 243 LSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHG---RFGA--- 296
Query: 244 IRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVAR 303
+ SD I + I+ +F + P + PK+F QAC+GE + P+ +
Sbjct: 297 VYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEE---------IQPSVSIEA 347
Query: 304 DGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLC 359
D P ++ L+ +T+PG++S R V+ GSWYIQ LC
Sbjct: 348 D-------ALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLC 396
>U13737-1|AAA65015.1| 277|Homo sapiens cysteine protease CPP32
isoform alpha protein.
Length = 277
Score = 62.1 bits (144), Expect = 3e-09
Identities = 59/216 (27%), Positives = 93/216 (43%), Gaps = 35/216 (16%)
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMS----SVLAGYECVFLVVS 230
+R G +VD L+ F + +EV +LT E+ + +S S + + CV L
Sbjct: 63 SRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLL--- 119
Query: 231 SHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
SHG E I ++G + L I ++F + + T PK+FI QACRG D
Sbjct: 120 SHGEEGI------IFGTNGP-VDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDC-- 170
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
+ D V + P+ ++ L A ST PG+ S R+ K
Sbjct: 171 ---------GIETDSGV----------DDDMACHKIPVDADFLYAYSTAPGYYSWRNSKD 211
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRF 386
GSW+IQ LC + + A + T V++++ F
Sbjct: 212 GSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEF 247
>AJ413269-1|CAC88866.1| 277|Homo sapiens caspase-3 protein.
Length = 277
Score = 62.1 bits (144), Expect = 3e-09
Identities = 59/216 (27%), Positives = 93/216 (43%), Gaps = 35/216 (16%)
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMS----SVLAGYECVFLVVS 230
+R G +VD L+ F + +EV +LT E+ + +S S + + CV L
Sbjct: 63 SRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLL--- 119
Query: 231 SHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
SHG E I ++G + L I ++F + + T PK+FI QACRG D
Sbjct: 120 SHGEEGI------IFGTNGP-VDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDC-- 170
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
+ D V + P+ ++ L A ST PG+ S R+ K
Sbjct: 171 ---------GIETDSGV----------DDDMACHKIPVDADFLYAYSTAPGYYSWRNSKD 211
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRF 386
GSW+IQ LC + + A + T V++++ F
Sbjct: 212 GSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEF 247
>AK223503-1|BAD97223.1| 404|Homo sapiens caspase 1 isoform alpha
precursor variant protein.
Length = 404
Score = 61.3 bits (142), Expect = 6e-09
Identities = 90/404 (22%), Positives = 152/404 (37%), Gaps = 27/404 (6%)
Query: 15 SLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYREITRRGPQAFTMLLE 74
S+ EGT ++ ++ L + V +++ +E + + T ++ R L + +G QA + +
Sbjct: 16 SMGEGT-INGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICIT 74
Query: 75 ALRE-----MGHWDLVRDLDPNSPLQLRARRPVLP--PTRQGSDAXXXXXXXNSSEPVAI 127
+ E G L D + L ++ + VL P Q + SE
Sbjct: 75 YICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVK 134
Query: 128 PCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIEPNRDGVNVDCDKLK 187
C ++++ ++ + + SR R L++ + + P R G VD +
Sbjct: 135 LC-SLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEE---FDSIPRRTGAEVDITGMT 190
Query: 188 YLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSSHG-HERRYSSDTDI 244
L +G+ V +NLT LE + + FLV SHG E
Sbjct: 191 MLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSE 250
Query: 245 RCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARD 304
+ D + L AI + N + P+ D PKV I QACRG++ V ++
Sbjct: 251 QVPD--ILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSV--------- 299
Query: 305 GAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAE 364
G + + + + S+ P +S R GS +I L E E
Sbjct: 300 GVSGNLSLPTTEEFEDDAIRKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQE 359
Query: 365 RAHDCHVDELFTLVDKRLRLRFGR-QTSSVDRWGFNNKLYLHPG 407
A C V+E+F V GR Q + +R YL G
Sbjct: 360 YACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFLG 403
>U13698-1|AAC50108.1| 311|Homo sapiens interleukin 1-beta
converting enzyme isoform gamma protein.
Length = 311
Score = 60.9 bits (141), Expect = 8e-09
Identities = 62/238 (26%), Positives = 88/238 (36%), Gaps = 15/238 (6%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R G VD + L +G+ V +NLT LE + + FLV S
Sbjct: 84 PRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMS 143
Query: 232 HG-HERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
HG E + D + L AI + N + P+ D PKV I QACRG++ V
Sbjct: 144 HGIREGICGKKHSEQVPD--ILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVW 201
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
++ G + + + + S+ P +S R
Sbjct: 202 FKDSV---------GVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTM 252
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGR-QTSSVDRWGFNNKLYLHPG 407
GS +I L E E A C V+E+F V GR Q + +R YL PG
Sbjct: 253 GSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPG 310
>BC062327-1|AAH62327.1| 311|Homo sapiens caspase 1,
apoptosis-related cysteine peptidase (interleukin 1,
beta, convertas protein.
Length = 311
Score = 60.9 bits (141), Expect = 8e-09
Identities = 62/238 (26%), Positives = 88/238 (36%), Gaps = 15/238 (6%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R G VD + L +G+ V +NLT LE + + FLV S
Sbjct: 84 PRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMS 143
Query: 232 HG-HERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
HG E + D + L AI + N + P+ D PKV I QACRG++ V
Sbjct: 144 HGIREGICGKKHSEQVPD--ILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVW 201
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
++ G + + + + S+ P +S R
Sbjct: 202 FKDSV---------GVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTM 252
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGR-QTSSVDRWGFNNKLYLHPG 407
GS +I L E E A C V+E+F V GR Q + +R YL PG
Sbjct: 253 GSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPG 310
>AY660536-1|AAT72297.1| 365|Homo sapiens caspase-1 isoform zeta
precursor protein.
Length = 365
Score = 60.9 bits (141), Expect = 8e-09
Identities = 62/238 (26%), Positives = 88/238 (36%), Gaps = 15/238 (6%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R G VD + L +G+ V +NLT LE + + FLV S
Sbjct: 138 PRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMS 197
Query: 232 HG-HERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQ 290
HG E + D + L AI + N + P+ D PKV I QACRG++ V
Sbjct: 198 HGIREGICGKKHSEQVPD--ILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVW 255
Query: 291 GGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKA 350
++ G + + + + S+ P +S R
Sbjct: 256 FKDSV---------GVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTM 306
Query: 351 GSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRFGR-QTSSVDRWGFNNKLYLHPG 407
GS +I L E E A C V+E+F V GR Q + +R YL PG
Sbjct: 307 GSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPG 364
>U20537-1|AAC50169.1| 204|Homo sapiens cysteine protease Mch2
isoform beta protein.
Length = 204
Score = 60.5 bits (140), Expect = 1e-08
Identities = 46/166 (27%), Positives = 63/166 (37%), Gaps = 15/166 (9%)
Query: 220 AGYECVFLVVSSHGHERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQ 279
A +C V SHG I D K I + + F K + PK+FI Q
Sbjct: 20 ADADCFVCVFLSHGEGNH------IYAYDAK-IEIQTLTGLFKGDKCHSLVGKPKIFIIQ 72
Query: 280 ACRGENEDFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTL 339
ACRG D + P V P ++ L+ S
Sbjct: 73 ACRGNQHDV-----PVIPLDVVDNQ---TEKLDTNITEVDAASVYTLPAGADFLMCYSVA 124
Query: 340 PGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLR 385
G+ SHR+ GSWYIQ LCE+ + EL TLV++++ R
Sbjct: 125 EGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQR 170
>AL512883-4|CAI12971.1| 197|Homo sapiens caspase 9,
apoptosis-related cysteine peptidase protein.
Length = 197
Score = 59.3 bits (137), Expect = 2e-08
Identities = 36/110 (32%), Positives = 55/110 (50%), Gaps = 2/110 (1%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQ-TRATLEQMSSVLAGYECVFLVVSSHGH 234
R G N+DC+KL+ FS + F V +LT ++ A LE +C +V+ SHG
Sbjct: 21 RTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGC 80
Query: 235 ERRYSSDTD-IRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRG 283
+ + + +DG +S+ IV+ FN P+ PK+F QAC G
Sbjct: 81 QASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGG 130
Score = 39.5 bits (88), Expect = 0.021
Identities = 16/38 (42%), Positives = 24/38 (63%)
Query: 341 GFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLV 378
GF+S RD K+GSWY++ L ++F + AH + L V
Sbjct: 131 GFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRV 168
>AY358222-1|AAQ88589.1| 341|Homo sapiens CASP12P1 protein.
Length = 341
Score = 58.4 bits (135), Expect = 4e-08
Identities = 57/242 (23%), Positives = 92/242 (38%), Gaps = 23/242 (9%)
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSSH 232
NR+G +D ++ L +G+ V+ +NLT ++ L Q ++ + FLV SH
Sbjct: 113 NRNGSELDLLGMRDLLENLGYSVVIKENLTAQEMETALRQFAAHPEHQSSDSTFLVFMSH 172
Query: 233 G------HERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENE 286
+ + + D+ D I + FNNR + D PKV I QACRG
Sbjct: 173 SILNGICGTKHWDQEPDVLHDD-------TIFEIFNNRNCQSLKDKPKVIIMQACRGNGA 225
Query: 287 DFVQGGGALAPAPQVARDGAVXXXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHR 346
V + + + D EK + + S+ P +S R
Sbjct: 226 GIV---WFTTDSGKASADTHGRLLQGNICNDAVTKAHVEK----DFIAFKSSTPHNVSWR 278
Query: 347 DVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRL-RFGRQTSSVDRWGFNNKLYLH 405
GS +I + F E + H++E+F V Q +++R YL
Sbjct: 279 HETNGSVFISQIIYYFREYSWSHHLEEIFQKVQHSFETPNILTQLPTIERLSMTRYFYLF 338
Query: 406 PG 407
PG
Sbjct: 339 PG 340
>X98174-1|CAA66855.1| 266|Homo sapiens MACH-alpha-3 protein.
Length = 266
Score = 55.6 bits (128), Expect = 3e-07
Identities = 44/177 (24%), Positives = 76/177 (42%), Gaps = 19/177 (10%)
Query: 190 FSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSD 248
F E+ FE+ + + T+EQ L+ + + +C + SHG + I +D
Sbjct: 61 FEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGI------IYGTD 114
Query: 249 GKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGENEDFVQGGGALAPAPQVARDGAVX 308
G+ +Y + F K P+ PKVF QAC+G+N + +G P + +
Sbjct: 115 GQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDN--YQKG----IPVETDSEEQPYL 168
Query: 309 XXXXXXXXXXXXXXXXEKPLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAER 365
P ++ L+ +T+ +S+R+ G+WYIQ LC+ ER
Sbjct: 169 EMDLSSPQTRYI------PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER 219
>U13699-1|AAC50109.1| 263|Homo sapiens Interleukin 1-beta
converting enzyme isoform delta protein.
Length = 263
Score = 53.6 bits (123), Expect = 1e-06
Identities = 37/115 (32%), Positives = 49/115 (42%), Gaps = 5/115 (4%)
Query: 174 PNRDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSS 231
P R G VD + L +G+ V +NLT LE + + FLV S
Sbjct: 84 PRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMS 143
Query: 232 HG-HERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRGEN 285
HG E + D + L AI + N + P+ D PKV I QACRG+N
Sbjct: 144 HGIREGICGKKHSEQVPD--ILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDN 196
>AL512883-6|CAI12973.1| 266|Homo sapiens caspase 9,
apoptosis-related cysteine peptidase protein.
Length = 266
Score = 51.6 bits (118), Expect = 5e-06
Identities = 22/52 (42%), Positives = 33/52 (63%)
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLV 378
P S+I ++ ST PGF+S RD K+GSWY++ L ++F + AH + L V
Sbjct: 186 PTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRV 237
Score = 36.3 bits (80), Expect = 0.20
Identities = 24/81 (29%), Positives = 40/81 (49%), Gaps = 1/81 (1%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEP-YRDTSITPRERKRILYR 59
M E ++ ++R LVE +D + AL + +F MIE R S + R++ R L
Sbjct: 1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
Query: 60 EITRRGPQAFTMLLEALREMG 80
++ RG QA + + L + G
Sbjct: 61 DLETRGSQALPLFISCLEDTG 81
>AF110376-1|AAD13615.1| 266|Homo sapiens caspase-9S precursor
protein.
Length = 266
Score = 51.6 bits (118), Expect = 5e-06
Identities = 22/52 (42%), Positives = 33/52 (63%)
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLV 378
P S+I ++ ST PGF+S RD K+GSWY++ L ++F + AH + L V
Sbjct: 186 PTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRV 237
Score = 34.7 bits (76), Expect = 0.60
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 1/81 (1%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEP-YRDTSITPRERKRILYR 59
M E ++ ++R LVE +D + L + +F MIE R S + R++ R L
Sbjct: 1 MDEADRRLLRRCRLRLVEELQVDQLWDVLLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
Query: 60 EITRRGPQAFTMLLEALREMG 80
++ RG QA + + L + G
Sbjct: 61 DLETRGSQALPLFISCLEDTG 81
>AF093130-1|AAD12248.1| 266|Homo sapiens caspase 9 short isoform
protein.
Length = 266
Score = 51.6 bits (118), Expect = 5e-06
Identities = 22/52 (42%), Positives = 33/52 (63%)
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLV 378
P S+I ++ ST PGF+S RD K+GSWY++ L ++F + AH + L V
Sbjct: 186 PTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRV 237
Score = 36.3 bits (80), Expect = 0.20
Identities = 24/81 (29%), Positives = 40/81 (49%), Gaps = 1/81 (1%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEP-YRDTSITPRERKRILYR 59
M E ++ ++R LVE +D + AL + +F MIE R S + R++ R L
Sbjct: 1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
Query: 60 EITRRGPQAFTMLLEALREMG 80
++ RG QA + + L + G
Sbjct: 61 DLETRGSQALPLFISCLEDTG 81
>AB020979-1|BAA87905.1| 266|Homo sapiens caspase-9 protein.
Length = 266
Score = 51.6 bits (118), Expect = 5e-06
Identities = 22/52 (42%), Positives = 33/52 (63%)
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLV 378
P S+I ++ ST PGF+S RD K+GSWY++ L ++F + AH + L V
Sbjct: 186 PTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRV 237
Score = 35.5 bits (78), Expect = 0.34
Identities = 24/81 (29%), Positives = 39/81 (48%), Gaps = 1/81 (1%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEP-YRDTSITPRERKRILYR 59
M E ++ ++R LVE +D + AL +F MIE R S + R++ R L
Sbjct: 1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSSELFRPHMIEDIQRAGSGSRRDQARQLII 60
Query: 60 EITRRGPQAFTMLLEALREMG 80
++ RG QA + + L + G
Sbjct: 61 DLETRGSQALPLFISCLEDTG 81
>AB015653-1|BAA78780.1| 266|Homo sapiens caspase-9 beta protein.
Length = 266
Score = 51.6 bits (118), Expect = 5e-06
Identities = 22/52 (42%), Positives = 33/52 (63%)
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLV 378
P S+I ++ ST PGF+S RD K+GSWY++ L ++F + AH + L V
Sbjct: 186 PTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRV 237
Score = 36.3 bits (80), Expect = 0.20
Identities = 24/81 (29%), Positives = 40/81 (49%), Gaps = 1/81 (1%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEP-YRDTSITPRERKRILYR 59
M E ++ ++R LVE +D + AL + +F MIE R S + R++ R L
Sbjct: 1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
Query: 60 EITRRGPQAFTMLLEALREMG 80
++ RG QA + + L + G
Sbjct: 61 DLETRGSQALPLFISCLEDTG 81
>AB209640-1|BAD92877.1| 144|Homo sapiens caspase 2 isoform 2
precursor variant protein.
Length = 144
Score = 49.6 bits (113), Expect = 2e-05
Identities = 23/61 (37%), Positives = 37/61 (60%)
Query: 327 PLYSNILIANSTLPGFISHRDVKAGSWYIQVLCEVFAERAHDCHVDELFTLVDKRLRLRF 386
P S+++ + L G + R+ K GSWYI+ L +VF+ERA D HV ++ V+ ++ R
Sbjct: 51 PTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDRE 110
Query: 387 G 387
G
Sbjct: 111 G 111
>AL627395-3|CAI16006.1| 222|Homo sapiens caspase 7,
apoptosis-related cysteine peptidase protein.
Length = 222
Score = 42.3 bits (95), Expect = 0.003
Identities = 31/117 (26%), Positives = 53/117 (45%), Gaps = 9/117 (7%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGH 234
R+G + D + L F +GF+V+ Y + + + + L++ S C ++ SHG
Sbjct: 87 RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGE 146
Query: 235 ERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRG-ENEDFVQ 290
E I DG + + +F + + PK+F QACRG E +D +Q
Sbjct: 147 E------NVIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQ 196
>AL592546-5|CAI12640.1| 222|Homo sapiens caspase 7,
apoptosis-related cysteine peptidase protein.
Length = 222
Score = 42.3 bits (95), Expect = 0.003
Identities = 31/117 (26%), Positives = 53/117 (45%), Gaps = 9/117 (7%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGH 234
R+G + D + L F +GF+V+ Y + + + + L++ S C ++ SHG
Sbjct: 87 RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGE 146
Query: 235 ERRYSSDTDIRCSDGKFISLYAIVDYFNNRKLPNFTDLPKVFIFQACRG-ENEDFVQ 290
E I DG + + +F + + PK+F QACRG E +D +Q
Sbjct: 147 E------NVIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQ 196
>AF422927-1|AAL87630.1| 339|Homo sapiens procaspase-8 protein.
Length = 339
Score = 41.1 bits (92), Expect = 0.007
Identities = 34/146 (23%), Positives = 67/146 (45%), Gaps = 16/146 (10%)
Query: 140 EDDVSRDI-QLYRTRSRKRGVLVVFSYISFL--------LNIEPNRDGVNVDCDKLKYLF 190
+D S+ + ++Y+ +S+ RG ++ + +F L+ +R+G ++D L F
Sbjct: 200 QDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTF 259
Query: 191 SEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDG 249
E+ FE+ + + T+EQ L+ + + +C + SHG + I +DG
Sbjct: 260 EELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDK------GIIYGTDG 313
Query: 250 KFISLYAIVDYFNNRKLPNFTDLPKV 275
+ +Y + F K P+ PKV
Sbjct: 314 QEAPIYELTSQFTGLKCPSLAGKPKV 339
>AL050391-1|CAB43686.2| 104|Homo sapiens hypothetical protein
protein.
Length = 104
Score = 39.5 bits (88), Expect = 0.021
Identities = 33/102 (32%), Positives = 46/102 (45%), Gaps = 7/102 (6%)
Query: 186 LKYLFSEIGFEVLTYQNLTLEQTRATLEQMSS--VLAGYECVFLVVSSHGH-ERRYSSDT 242
+K L + + V +NLT + L ++ + FLV+ SHG E +
Sbjct: 3 MKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVH 62
Query: 243 DIRCSDGKFISLY-AIVDYFNNRKLPNFTDLPKVFIFQACRG 283
D + D + LY I FNNR + D PKV I QACRG
Sbjct: 63 DEKKPD---VLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRG 101
>AL512883-8|CAI12974.1| 254|Homo sapiens caspase 9,
apoptosis-related cysteine peptidase protein.
Length = 254
Score = 37.9 bits (84), Expect = 0.064
Identities = 48/210 (22%), Positives = 83/210 (39%), Gaps = 8/210 (3%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEP-YRDTSITPRERKRILYR 59
M E ++ ++R LVE +D + AL + +F MIE R S + R++ R L
Sbjct: 1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
Query: 60 EITRRGPQAFTMLLEALREMGHWDLVRDLDPNSPLQLRARRPVL----PPTRQGSDAXXX 115
++ RG QA + + L + G D++ + + +P L P +
Sbjct: 61 DLETRGSQALPLFISCLEDTGQ-DMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPE 119
Query: 116 XXXXNSSEPVAIPCFHVKKSTHFFEDDVSRDIQLYRTRSRKRGVLVVFSYISFLLNIE-P 174
+ PV I + D+ Y G ++ + ++F
Sbjct: 120 VLRPETPRPVDIGSGGFGDVGALESLRGNADL-AYILSMEPCGHCLIINNVNFCRESGLR 178
Query: 175 NRDGVNVDCDKLKYLFSEIGFEVLTYQNLT 204
R G N+DC+KL+ FS + F V +LT
Sbjct: 179 TRTGSNIDCEKLRRRFSSLHFMVEVKGDLT 208
>AF422928-1|AAL87631.1| 353|Homo sapiens procaspase-8 protein.
Length = 353
Score = 36.3 bits (80), Expect = 0.20
Identities = 32/145 (22%), Positives = 65/145 (44%), Gaps = 16/145 (11%)
Query: 140 EDDVSRDI-QLYRTRSRKRGVLVVFSYISFL--------LNIEPNRDGVNVDCDKLKYLF 190
+D S+ + ++Y+ +S+ RG ++ + +F L+ +R+G ++D L F
Sbjct: 215 QDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTF 274
Query: 191 SEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGHERRYSSDTDIRCSDG 249
E+ FE+ + + T+EQ L+ + + +C + SHG + I +DG
Sbjct: 275 EELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDK------GIIYGTDG 328
Query: 250 KFISLYAIVDYFNNRKLPNFTDLPK 274
+ +Y + F P+ PK
Sbjct: 329 QEAPIYELTSQFTGFGCPSLAGKPK 353
>AY732490-1|AAV33129.1| 154|Homo sapiens caspase 9 splice variant
protein.
Length = 154
Score = 34.7 bits (76), Expect = 0.60
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 1/81 (1%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEP-YRDTSITPRERKRILYR 59
M E ++ ++R LVE +D + L + +F MIE R S + R++ R L
Sbjct: 1 MDEADRRLLRRCRLRLVEELQVDQLWDVLLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
Query: 60 EITRRGPQAFTMLLEALREMG 80
++ RG QA + + L + G
Sbjct: 61 DLETRGSQALPLFISCLEDTG 81
>AJ781267-1|CAH03131.1| 95|Homo sapiens caspase-9c protein
protein.
Length = 95
Score = 34.7 bits (76), Expect = 0.60
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 1/81 (1%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEP-YRDTSITPRERKRILYR 59
M E ++ ++R LVE +D + L + +F MIE R S + R++ R L
Sbjct: 1 MDEADRRPLRRCRLRLVEELQVDQLWDVLLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
Query: 60 EITRRGPQAFTMLLEALREMG 80
++ RG QA + + L + G
Sbjct: 61 DLETRGSQALPLFISCLEDTG 81
>BC131610-1|AAI31611.1| 90|Homo sapiens ICEBERG caspase-1
inhibitor protein.
Length = 90
Score = 31.9 bits (69), Expect = 4.2
Identities = 19/78 (24%), Positives = 40/78 (51%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M ++ + +R F V +++++ L E V SQ+ + RD + T ++ R+L
Sbjct: 1 MADQLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDL 60
Query: 61 ITRRGPQAFTMLLEALRE 78
+T +GP++ ++ L E
Sbjct: 61 VTGKGPKSCCKFIKHLCE 78
>AY358231-1|AAQ88598.1| 90|Homo sapiens ICEBERG protein.
Length = 90
Score = 31.9 bits (69), Expect = 4.2
Identities = 19/78 (24%), Positives = 40/78 (51%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M ++ + +R F V +++++ L E V SQ+ + RD + T ++ R+L
Sbjct: 1 MADQLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDL 60
Query: 61 ITRRGPQAFTMLLEALRE 78
+T +GP++ ++ L E
Sbjct: 61 VTGKGPKSCCKFIKHLCE 78
>AF208005-1|AAG23528.1| 90|Homo sapiens ICEBERG caspase-1
inhibitor protein.
Length = 90
Score = 31.9 bits (69), Expect = 4.2
Identities = 19/78 (24%), Positives = 40/78 (51%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M ++ + +R F V +++++ L E V SQ+ + RD + T ++ R+L
Sbjct: 1 MADQLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDL 60
Query: 61 ITRRGPQAFTMLLEALRE 78
+T +GP++ ++ L E
Sbjct: 61 VTGKGPKSCCKFIKHLCE 78
>U37449-1|AAC50304.1| 253|Homo sapiens Mch3 isoform beta protein.
Length = 253
Score = 31.5 bits (68), Expect = 5.6
Identities = 17/65 (26%), Positives = 31/65 (47%), Gaps = 1/65 (1%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGH 234
R+G + D + L F +GF+V+ Y + + + + L++ S C ++ SHG
Sbjct: 87 RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGE 146
Query: 235 ERRYS 239
E S
Sbjct: 147 ENMES 151
>AL627395-2|CAI16005.1| 253|Homo sapiens caspase 7,
apoptosis-related cysteine peptidase protein.
Length = 253
Score = 31.5 bits (68), Expect = 5.6
Identities = 17/65 (26%), Positives = 31/65 (47%), Gaps = 1/65 (1%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGH 234
R+G + D + L F +GF+V+ Y + + + + L++ S C ++ SHG
Sbjct: 87 RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGE 146
Query: 235 ERRYS 239
E S
Sbjct: 147 ENMES 151
>AL592546-3|CAI12639.1| 253|Homo sapiens caspase 7,
apoptosis-related cysteine peptidase protein.
Length = 253
Score = 31.5 bits (68), Expect = 5.6
Identities = 17/65 (26%), Positives = 31/65 (47%), Gaps = 1/65 (1%)
Query: 176 RDGVNVDCDKLKYLFSEIGFEVLTYQNLTLEQTRATLEQMSSV-LAGYECVFLVVSSHGH 234
R+G + D + L F +GF+V+ Y + + + + L++ S C ++ SHG
Sbjct: 87 RNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGE 146
Query: 235 ERRYS 239
E S
Sbjct: 147 ENMES 151
>AF314175-1|AAK00300.1| 77|Homo sapiens Casp-2S-Pro protein.
Length = 77
Score = 30.7 bits (66), Expect = 9.8
Identities = 20/76 (26%), Positives = 36/76 (47%), Gaps = 1/76 (1%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M H++ +++N L + L ++ L EK + + +M E + + + L
Sbjct: 1 MHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQ-AKVGSFSQNVELLNL 59
Query: 61 ITRRGPQAFTMLLEAL 76
+ +RGPQAF EAL
Sbjct: 60 LPKRGPQAFDAFCEAL 75
>AF314174-1|AAK00299.1| 91|Homo sapiens Casp-2L-Pro protein.
Length = 91
Score = 30.7 bits (66), Expect = 9.8
Identities = 20/76 (26%), Positives = 36/76 (47%), Gaps = 1/76 (1%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M H++ +++N L + L ++ L EK + + +M E + + + L
Sbjct: 15 MHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQ-AKVGSFSQNVELLNL 73
Query: 61 ITRRGPQAFTMLLEAL 76
+ +RGPQAF EAL
Sbjct: 74 LPKRGPQAFDAFCEAL 89
>AC073342-4|AAP22349.1| 77|Homo sapiens unknown protein.
Length = 77
Score = 30.7 bits (66), Expect = 9.8
Identities = 20/76 (26%), Positives = 36/76 (47%), Gaps = 1/76 (1%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M H++ +++N L + L ++ L EK + + +M E + + + L
Sbjct: 1 MHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQ-AKVGSFSQNVELLNL 59
Query: 61 ITRRGPQAFTMLLEAL 76
+ +RGPQAF EAL
Sbjct: 60 LPKRGPQAFDAFCEAL 75
>AC073342-2|AAP22348.1| 91|Homo sapiens unknown protein.
Length = 91
Score = 30.7 bits (66), Expect = 9.8
Identities = 20/76 (26%), Positives = 36/76 (47%), Gaps = 1/76 (1%)
Query: 1 MQEEHKKAIQRNFSSLVEGTDLDSMVMALYEKGVFSQQMIEPYRDTSITPRERKRILYRE 60
M H++ +++N L + L ++ L EK + + +M E + + + L
Sbjct: 15 MHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQ-AKVGSFSQNVELLNL 73
Query: 61 ITRRGPQAFTMLLEAL 76
+ +RGPQAF EAL
Sbjct: 74 LPKRGPQAFDAFCEAL 89
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.322 0.138 0.414
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 55,997,334
Number of Sequences: 224733
Number of extensions: 2171237
Number of successful extensions: 3410
Number of sequences better than 10.0: 117
Number of HSP's better than 10.0 without gapping: 103
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 3095
Number of HSP's gapped (non-prelim): 221
length of query: 410
length of database: 73,234,838
effective HSP length: 92
effective length of query: 318
effective length of database: 52,559,402
effective search space: 16713889836
effective search space used: 16713889836
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 66 (30.7 bits)
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