Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002748-TA|BGIBMGA002748-PA|IPR002126|Cadherin
(1518 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AY010111-1|AAG27034.2| 3354|Homo sapiens cadherin 23 protein. 161 1e-38
AL772287-2|CAI13626.1| 3359|Homo sapiens cadherin-like 23 protein. 161 1e-38
AL731541-6|CAI40841.1| 3359|Homo sapiens cadherin-like 23 protein. 161 1e-38
AL359183-3|CAI13426.1| 3359|Homo sapiens cadherin-like 23 protein. 161 1e-38
AF312024-1|AAG48303.1| 3354|Homo sapiens cadherin related 23 pro... 161 1e-38
X87241-1|CAA60685.1| 4590|Homo sapiens homologue of Drosophila F... 157 2e-37
AF231022-1|AAF61928.1| 4349|Homo sapiens protocadherin Fat 2 pro... 147 3e-34
AY356402-1|AAR13653.1| 3222|Homo sapiens fat-like cadherin FATJ ... 145 1e-33
AL031597-2|CAI23555.1| 3014|Homo sapiens cadherin, EGF LAG seven... 144 2e-33
AL031588-3|CAI19319.1| 3014|Homo sapiens cadherin, EGF LAG seven... 144 2e-33
AL021392-2|CAI20967.1| 3014|Homo sapiens cadherin, EGF LAG seven... 144 2e-33
AF231024-1|AAF61930.1| 3014|Homo sapiens protocadherin Flamingo ... 144 2e-33
BC065284-1|AAH65284.1| 1381|Homo sapiens CDH23 protein protein. 143 5e-33
BC032581-1|AAH32581.1| 1061|Homo sapiens CDH23 protein protein. 143 5e-33
BX537422-1|CAD97664.1| 1203|Homo sapiens hypothetical protein pr... 142 7e-33
AL834258-1|CAD38933.1| 1084|Homo sapiens hypothetical protein pr... 142 7e-33
AL603863-3|CAM17491.1| 1237|Homo sapiens protocadherin 9 protein. 142 7e-33
AL603863-2|CAH72759.1| 1203|Homo sapiens protocadherin 9 protein. 142 7e-33
AL603863-1|CAH72758.1| 1032|Homo sapiens protocadherin 9 protein. 142 7e-33
AL355173-2|CAH72612.1| 1203|Homo sapiens protocadherin 9 protein. 142 7e-33
AL355173-1|CAM17290.1| 1237|Homo sapiens protocadherin 9 protein. 142 7e-33
AL138814-1|CAM13066.1| 1237|Homo sapiens protocadherin 9 protein. 142 7e-33
AL136999-2|CAI12502.1| 1203|Homo sapiens protocadherin 9 protein. 142 7e-33
AL136999-1|CAM13771.1| 1237|Homo sapiens protocadherin 9 protein. 142 7e-33
AF169692-1|AAF89689.2| 1203|Homo sapiens protocadherin-9 protein. 142 7e-33
AY029237-1|AAK31804.1| 1955|Homo sapiens protocadherin 15 protein. 139 6e-32
AY029205-1|AAK31581.1| 1955|Homo sapiens protocadherin 15 protein. 139 6e-32
AL365496-10|CAM19874.1| 1957|Homo sapiens protocadherin 15 protein. 139 6e-32
AL365496-9|CAH73916.1| 1955|Homo sapiens protocadherin 15 protein. 139 6e-32
AL365496-8|CAM19873.1| 1952|Homo sapiens protocadherin 15 protein. 139 6e-32
AL365496-7|CAM19872.1| 1932|Homo sapiens protocadherin 15 protein. 139 6e-32
AL365496-4|CAM19869.1| 1539|Homo sapiens protocadherin 15 protein. 139 6e-32
AL365496-3|CAM19868.1| 1785|Homo sapiens protocadherin 15 protein. 139 6e-32
AL365496-1|CAM19866.1| 1684|Homo sapiens protocadherin 15 protein. 139 6e-32
AL360214-13|CAM21544.1| 1932|Homo sapiens protocadherin 15 protein. 139 6e-32
AL360214-12|CAM21543.1| 1952|Homo sapiens protocadherin 15 protein. 139 6e-32
AL360214-11|CAM21542.1| 1957|Homo sapiens protocadherin 15 protein. 139 6e-32
AL360214-10|CAI15201.1| 1955|Homo sapiens protocadherin 15 protein. 139 6e-32
AL360214-6|CAM21538.1| 1785|Homo sapiens protocadherin 15 protein. 139 6e-32
AL360214-5|CAM21537.1| 1539|Homo sapiens protocadherin 15 protein. 139 6e-32
AL360214-4|CAM21536.1| 1684|Homo sapiens protocadherin 15 protein. 139 6e-32
AL360214-3|CAI15200.1| 961|Homo sapiens protocadherin 15 protein. 139 6e-32
AL356114-13|CAH71769.1| 1955|Homo sapiens protocadherin 15 protein. 139 6e-32
AL356114-12|CAM15125.1| 1932|Homo sapiens protocadherin 15 protein. 139 6e-32
AL356114-11|CAM15124.1| 1957|Homo sapiens protocadherin 15 protein. 139 6e-32
AL356114-10|CAM15123.1| 1952|Homo sapiens protocadherin 15 protein. 139 6e-32
AL356114-7|CAM15120.1| 1539|Homo sapiens protocadherin 15 protein. 139 6e-32
AL356114-6|CAM15119.1| 1785|Homo sapiens protocadherin 15 protein. 139 6e-32
AL356114-4|CAM15117.1| 1684|Homo sapiens protocadherin 15 protein. 139 6e-32
AL356114-3|CAH71768.1| 961|Homo sapiens protocadherin 15 protein. 139 6e-32
AL353784-11|CAM16792.1| 1957|Homo sapiens protocadherin 15 protein. 139 6e-32
AL353784-10|CAH72390.1| 1955|Homo sapiens protocadherin 15 protein. 139 6e-32
AL353784-9|CAM16791.1| 1952|Homo sapiens protocadherin 15 protein. 139 6e-32
AL353784-7|CAM16789.1| 1785|Homo sapiens protocadherin 15 protein. 139 6e-32
AL353784-5|CAM16787.1| 1539|Homo sapiens protocadherin 15 protein. 139 6e-32
AL353784-3|CAM16785.1| 1684|Homo sapiens protocadherin 15 protein. 139 6e-32
AL353784-2|CAH72389.1| 961|Homo sapiens protocadherin 15 protein. 139 6e-32
AY861435-1|AAX56125.1| 1065|Homo sapiens protocadherin 11X isofo... 138 2e-31
AY861434-1|AAX56124.1| 1329|Homo sapiens protocadherin 11X isofo... 138 2e-31
AY861433-1|AAX56123.1| 1310|Homo sapiens protocadherin 11X isofo... 138 2e-31
AY861432-1|AAX56122.1| 1339|Homo sapiens protocadherin 11X isofo... 138 2e-31
AL133321-2|CAI41436.1| 1337|Homo sapiens protocadherin 11 X-link... 138 2e-31
AL133321-1|CAI41435.1| 1347|Homo sapiens protocadherin 11 X-link... 138 2e-31
AL133274-3|CAI41629.1| 1310|Homo sapiens protocadherin 11 X-link... 138 2e-31
AL133274-2|CAI41631.1| 1337|Homo sapiens protocadherin 11 X-link... 138 2e-31
AL133274-1|CAI41630.1| 1347|Homo sapiens protocadherin 11 X-link... 138 2e-31
AL121869-5|CAI41414.1| 1337|Homo sapiens protocadherin 11 X-link... 138 2e-31
AL121869-4|CAI41413.1| 1347|Homo sapiens protocadherin 11 X-link... 138 2e-31
AL121869-3|CAI41412.1| 1310|Homo sapiens protocadherin 11 X-link... 138 2e-31
AJ564963-1|CAD92434.1| 787|Homo sapiens protocadherin protein. 138 2e-31
AJ564962-1|CAD92433.1| 762|Homo sapiens protocadherin protein. 138 2e-31
AJ564961-1|CAD92432.1| 841|Homo sapiens protocadherin protein. 138 2e-31
AJ564960-1|CAD92431.1| 831|Homo sapiens protocadherin protein. 138 2e-31
AJ564936-1|CAD92415.1| 787|Homo sapiens protocadherin protein. 138 2e-31
AJ564935-1|CAD92414.1| 762|Homo sapiens protocadherin protein. 138 2e-31
AJ564934-1|CAD92413.1| 841|Homo sapiens protocadherin protein. 138 2e-31
AJ564933-1|CAD92412.1| 831|Homo sapiens protocadherin protein. 138 2e-31
AJ276804-1|CAC13123.1| 1025|Homo sapiens protocadherin protein. 138 2e-31
AJ276803-1|CAC13122.1| 1037|Homo sapiens protocadherin protein. 138 2e-31
AF332219-1|AAK13471.1| 1337|Homo sapiens protocadherin 11 protein. 138 2e-31
AF332218-1|AAK13470.1| 1347|Homo sapiens protocadherin 11 protein. 138 2e-31
AF332217-1|AAK13469.1| 1340|Homo sapiens protocadherin 11 protein. 138 2e-31
AF332216-1|AAK13468.1| 1048|Homo sapiens protocadherin 11 protein. 138 2e-31
AF277053-1|AAL55729.1| 1037|Homo sapiens protocadherin-PC protein. 138 2e-31
AB026187-1|BAA90765.1| 1021|Homo sapiens protocadherin-Xa protein. 138 2e-31
AL772287-1|CAI13625.2| 1066|Homo sapiens cadherin-like 23 protein. 135 1e-30
AL731541-5|CAM20296.1| 1066|Homo sapiens cadherin-like 23 protein. 135 1e-30
AL359183-2|CAI13425.2| 1066|Homo sapiens cadherin-like 23 protein. 135 1e-30
D87469-1|BAA13407.2| 2854|Homo sapiens KIAA0279 protein protein. 134 2e-30
AL390252-1|CAI13170.1| 2923|Homo sapiens cadherin, EGF LAG seven... 134 2e-30
AF234887-1|AAG00080.1| 2923|Homo sapiens FLAMINGO 1 protein. 134 2e-30
AB065955-1|BAC06168.1| 2923|Homo sapiens seven transmembrane hel... 134 2e-30
AF217288-1|AAK82656.1| 1310|Homo sapiens protocadherin-S protein. 133 4e-30
AF206516-1|AAK82655.1| 1347|Homo sapiens protocadherin-S protein. 133 4e-30
AF152515-1|AAD43775.1| 820|Homo sapiens protocadherin gamma A8 ... 128 2e-28
AF152328-1|AAD43722.1| 932|Homo sapiens protocadherin gamma A8 ... 128 2e-28
AB002325-1|BAA20785.2| 898|Homo sapiens KIAA0327 protein protein. 128 2e-28
AF152505-1|AAD43766.1| 837|Homo sapiens protocadherin gamma A11... 127 3e-28
AF152504-1|AAD43765.1| 750|Homo sapiens protocadherin gamma A11... 127 3e-28
AF152320-1|AAD43714.1| 935|Homo sapiens protocadherin gamma A11... 127 3e-28
BC013609-1|AAH13609.1| 796|Homo sapiens cadherin 11, type 2, OB... 126 5e-28
AB209760-1|BAD92997.1| 798|Homo sapiens cadherin 11, type 2 iso... 126 8e-28
BC000059-1|AAH00059.2| 771|Homo sapiens CELSR1 protein protein. 125 1e-27
D21255-1|BAA04799.1| 693|Homo sapiens OB-cadherin-2 protein. 125 1e-27
D21254-1|BAA04798.1| 796|Homo sapiens OB-cadherin-1 protein. 125 1e-27
AB006756-1|BAA25195.1| 1072|Homo sapiens PCDH7 (BH-Pcdh)b protein. 123 4e-27
AB006755-1|BAA25194.1| 1069|Homo sapiens PCDH7 (BH-Pcdh)a protein. 123 4e-27
AB075518-1|BAE45762.1| 656|Homo sapiens putative protein produc... 122 1e-26
AY354497-1|AAR10443.1| 2916|Homo sapiens cadherin protein protein. 122 1e-26
AF152519-1|AAD43779.1| 814|Homo sapiens protocadherin gamma B3 ... 121 2e-26
AF152332-1|AAD43726.1| 929|Homo sapiens protocadherin gamma B3 ... 121 2e-26
AF152511-1|AAD43771.1| 820|Homo sapiens protocadherin gamma A4 ... 120 3e-26
AF152324-1|AAD43718.1| 931|Homo sapiens protocadherin gamma A4 ... 120 3e-26
AY714129-1|AAU94938.1| 4186|Homo sapiens anchor protein protein. 118 1e-25
AF231023-1|AAF61929.1| 3312|Homo sapiens protocadherin Flamingo ... 118 1e-25
BC112084-1|AAI12085.1| 823|Homo sapiens protocadherin gamma sub... 117 3e-25
BC112082-1|AAI12083.1| 823|Homo sapiens protocadherin gamma sub... 117 3e-25
AB053446-1|BAB61903.2| 3434|Homo sapiens KIAA1773 protein protein. 117 3e-25
AF152507-1|AAD43768.1| 823|Homo sapiens protocadherin gamma A1 ... 117 4e-25
AF152318-1|AAD43712.1| 931|Homo sapiens protocadherin gamma A1 ... 117 4e-25
BC001186-1|AAH01186.1| 795|Homo sapiens protocadherin beta 5 pr... 115 1e-24
AF217753-1|AAK51620.1| 795|Homo sapiens protocadherin-beta5 pro... 115 1e-24
AF152498-1|AAD43759.1| 795|Homo sapiens protocadherin beta 5 pr... 115 1e-24
AF134474-1|AAP97251.1| 795|Homo sapiens protocadherin protein. 115 1e-24
AB209393-1|BAD92630.1| 796|Homo sapiens protocadherin beta 5 pr... 115 1e-24
AY358946-1|AAQ89305.1| 916|Homo sapiens cadherin FIB3 protein. 114 3e-24
AF152506-1|AAD43767.1| 820|Homo sapiens protocadherin gamma A12... 114 3e-24
AF152321-1|AAD43715.1| 932|Homo sapiens protocadherin gamma A12... 114 3e-24
AB011160-1|BAA25514.2| 938|Homo sapiens KIAA0588 protein protein. 114 3e-24
BC038797-1|AAH38797.1| 787|Homo sapiens protocadherin beta 15 p... 113 3e-24
AF217742-1|AAK51610.1| 787|Homo sapiens protocadherin-beta15 pr... 113 6e-24
AF152494-1|AAD43755.1| 787|Homo sapiens protocadherin beta 15 p... 113 6e-24
BC104817-1|AAI04818.1| 796|Homo sapiens protocadherin beta 3 pr... 112 1e-23
AK127704-1|BAC87093.1| 1366|Homo sapiens protein ( Homo sapiens ... 111 1e-23
AF217755-1|AAK51622.1| 796|Homo sapiens protocadherin-beta3 pro... 111 1e-23
AF152522-1|AAD43782.1| 820|Homo sapiens protocadherin gamma B6 ... 111 1e-23
AF152496-1|AAD43757.1| 796|Homo sapiens protocadherin beta 3 pr... 111 1e-23
AF152335-1|AAD43729.1| 930|Homo sapiens protocadherin gamma B6 ... 111 1e-23
AF152485-1|AAD43746.1| 789|Homo sapiens protocadherin alpha 7 s... 111 2e-23
AF152315-1|AAD43709.1| 937|Homo sapiens protocadherin alpha 7 p... 111 2e-23
AC005609-7|AAC34319.1| 789|Homo sapiens KIAA0345-like 7 protein. 111 2e-23
L11370-1|AAA36419.1| 1026|Homo sapiens protocadherin 42 protein. 111 2e-23
BC035812-1|AAH35812.1| 1060|Homo sapiens protocadherin 1 protein. 111 2e-23
AY013874-1|AAK21987.1| 896|Homo sapiens protocadherin 10 protein. 111 2e-23
AC105383-1|AAY41018.1| 1040|Homo sapiens unknown protein. 111 2e-23
AB037821-1|BAA92638.1| 1093|Homo sapiens KIAA1400 protein protein. 111 2e-23
BC113607-1|AAI13608.1| 803|Homo sapiens protocadherin gamma sub... 110 3e-23
BC112088-1|AAI12089.1| 803|Homo sapiens protocadherin gamma sub... 110 3e-23
BC033735-1|AAH33735.1| 890|Homo sapiens PCDHA5 protein protein. 110 3e-23
AF152520-1|AAD43780.1| 803|Homo sapiens protocadherin gamma B4 ... 110 3e-23
AF152333-1|AAD43727.1| 923|Homo sapiens protocadherin gamma B4 ... 110 3e-23
AF152483-1|AAD43744.1| 816|Homo sapiens protocadherin alpha 5 s... 110 4e-23
AF152313-1|AAD43707.1| 936|Homo sapiens protocadherin alpha 5 p... 110 4e-23
AC005609-9|AAC34321.1| 816|Homo sapiens KIAA0345-like 9 protein. 110 4e-23
BC111560-1|AAI11561.1| 1040|Homo sapiens protocadherin 10 protein. 109 6e-23
AB025106-1|BAA88957.1| 901|Homo sapiens E-cadherin protein. 109 6e-23
BC071934-1|AAH71934.1| 798|Homo sapiens protocadherin beta 13 p... 109 7e-23
BC051348-1|AAH51348.1| 798|Homo sapiens protocadherin beta 13 p... 109 7e-23
BC033068-1|AAH33068.1| 798|Homo sapiens protocadherin beta 13 p... 109 7e-23
AY358427-1|AAQ88793.1| 798|Homo sapiens PCDHB13 protein. 109 7e-23
AF217745-1|AAK51613.1| 798|Homo sapiens protocadherin-beta13 pr... 109 7e-23
AF152492-1|AAD43753.1| 798|Homo sapiens protocadherin beta 13 p... 109 7e-23
BC132769-1|AAI32770.1| 828|Homo sapiens protocadherin gamma sub... 109 1e-22
AF152516-1|AAD43776.1| 828|Homo sapiens protocadherin gamma A9 ... 109 1e-22
AF152329-1|AAD43723.1| 932|Homo sapiens protocadherin gamma A9 ... 109 1e-22
BC112098-1|AAI12099.1| 818|Homo sapiens protocadherin beta 1, p... 107 3e-22
BC112096-1|AAI12097.1| 818|Homo sapiens protocadherin beta 1, p... 107 3e-22
AF152488-1|AAD43749.1| 818|Homo sapiens protocadherin beta 1 pr... 107 3e-22
BC098346-1|AAH98346.1| 795|Homo sapiens protocadherin beta 4 pr... 107 4e-22
BC098139-1|AAH98139.1| 795|Homo sapiens protocadherin beta 4 pr... 107 4e-22
AF217754-1|AAK51621.1| 795|Homo sapiens protocadherin-beta4 pro... 107 4e-22
AF152497-1|AAD43758.1| 795|Homo sapiens protocadherin beta 4 pr... 107 4e-22
BC038799-1|AAH38799.1| 745|Homo sapiens PCDH21 protein protein. 106 5e-22
AB053448-1|BAB61905.1| 858|Homo sapiens KIAA1775 protein protein. 106 5e-22
BC093815-1|AAH93815.1| 1135|Homo sapiens protocadherin 18 protein. 106 7e-22
BC045637-1|AAH45637.1| 795|Homo sapiens protocadherin beta 12 p... 106 7e-22
AF217746-1|AAK51614.1| 795|Homo sapiens protocadherin-beta12 pr... 106 7e-22
AF152491-1|AAD43752.1| 795|Homo sapiens protocadherin beta 12 p... 106 7e-22
AB046782-1|BAB13388.1| 1136|Homo sapiens KIAA1562 protein protein. 106 7e-22
BC093879-1|AAH93879.1| 818|Homo sapiens protocadherin gamma sub... 105 9e-22
BC093877-1|AAH93877.1| 818|Homo sapiens protocadherin gamma sub... 105 9e-22
AF152521-1|AAD43781.1| 818|Homo sapiens protocadherin gamma B5 ... 105 9e-22
AF152514-1|AAD43774.1| 817|Homo sapiens protocadherin gamma A7 ... 105 9e-22
AF152334-1|AAD43728.1| 923|Homo sapiens protocadherin gamma B5 ... 105 9e-22
AF152327-1|AAD43721.1| 932|Homo sapiens protocadherin gamma A7 ... 105 9e-22
BC101049-1|AAI01050.1| 801|Homo sapiens cadherin 20, type 2 pro... 105 2e-21
BC101048-1|AAI01049.1| 801|Homo sapiens cadherin 20, type 2 pro... 105 2e-21
BC101047-1|AAI01048.1| 801|Homo sapiens cadherin 20, type 2 pro... 105 2e-21
BC051788-1|AAH51788.1| 929|Homo sapiens protocadherin gamma sub... 105 2e-21
AF217289-1|AAG23739.1| 801|Homo sapiens cadherin 20 protein. 105 2e-21
AF152523-1|AAD43783.1| 808|Homo sapiens protocadherin gamma B7 ... 105 2e-21
AF152478-1|AAD43739.1| 807|Homo sapiens protocadherin alpha 13 ... 105 2e-21
AF152336-1|AAD43730.1| 929|Homo sapiens protocadherin gamma B7 ... 105 2e-21
AF152309-1|AAD43703.1| 950|Homo sapiens protocadherin alpha 13 ... 105 2e-21
AC005609-1|AAC34314.1| 807|Homo sapiens KIAA0345-like 1 protein. 105 2e-21
AB208924-1|BAD92161.1| 921|Homo sapiens protocadherin alpha 13 ... 105 2e-21
BC103927-1|AAI03928.1| 810|Homo sapiens protocadherin gamma sub... 104 2e-21
BC103926-1|AAI03927.1| 810|Homo sapiens protocadherin gamma sub... 104 2e-21
BC052973-1|AAH52973.1| 1187|Homo sapiens PCDH12 protein protein. 104 2e-21
BC042634-1|AAH42634.1| 1187|Homo sapiens PCDH12 protein protein. 104 2e-21
AK024140-1|BAB14837.1| 1187|Homo sapiens protein ( Homo sapiens ... 104 2e-21
AF152517-1|AAD43777.1| 810|Homo sapiens protocadherin gamma B1 ... 104 2e-21
AF152330-1|AAD43724.1| 927|Homo sapiens protocadherin gamma B1 ... 104 2e-21
AB208958-1|BAD92195.1| 895|Homo sapiens protocadherin gamma sub... 104 2e-21
AL731541-3|CAI40838.1| 728|Homo sapiens cadherin-like 23 protein. 104 3e-21
AB058715-1|BAB47441.1| 803|Homo sapiens KIAA1812 protein protein. 104 3e-21
AB053445-1|BAB61902.1| 1147|Homo sapiens KIAA1774 protein protein. 104 3e-21
BC036062-1|AAH36062.1| 776|Homo sapiens protocadherin beta 16 p... 103 4e-21
AF282973-2|AAG10030.1| 776|Homo sapiens protocadherin-3x protein. 103 4e-21
AF217757-1|AAF81914.1| 776|Homo sapiens protocadherin 3X protein. 103 4e-21
AF240635-1|AAF73962.1| 1184|Homo sapiens vascular endothelial ca... 103 5e-21
AF231025-1|AAF61931.1| 1184|Homo sapiens protocadherin 12 protein. 103 5e-21
AB209225-1|BAD92462.1| 799|Homo sapiens protocadherin beta 11 p... 103 5e-21
AB026893-1|BAA95162.1| 1184|Homo sapiens vascular cadherin-2 pro... 103 5e-21
BC113611-1|AAI13612.1| 797|Homo sapiens protocadherin beta 11 p... 103 7e-21
BC113609-1|AAI13610.1| 798|Homo sapiens protocadherin alpha 4 p... 103 7e-21
BC112132-1|AAI12133.1| 797|Homo sapiens protocadherin beta 11 p... 103 7e-21
BC112102-1|AAI12103.1| 798|Homo sapiens protocadherin alpha 4, ... 103 7e-21
AY013878-1|AAK21988.1| 776|Homo sapiens protocadherin beta 8a p... 103 7e-21
AK093818-1|BAC04231.1| 455|Homo sapiens protein ( Homo sapiens ... 103 7e-21
AF217747-1|AAK51615.1| 797|Homo sapiens protocadherin-beta11 pr... 103 7e-21
AF152490-1|AAD43751.1| 797|Homo sapiens protocadherin beta 11 p... 103 7e-21
AF152482-1|AAD43743.1| 798|Homo sapiens protocadherin alpha 4 s... 103 7e-21
AF152312-1|AAD43706.1| 947|Homo sapiens protocadherin alpha 4 p... 103 7e-21
AC005609-10|AAC34322.1| 798|Homo sapiens KIAA0345-like 10 protein. 103 7e-21
AB208925-1|BAD92162.1| 921|Homo sapiens protocadherin alpha 4 i... 103 7e-21
AB046841-1|BAB13447.1| 787|Homo sapiens KIAA1621 protein protein. 103 7e-21
BC104804-1|AAI04805.1| 950|Homo sapiens protocadherin alpha 9 p... 102 9e-21
BC104802-1|AAI04803.1| 950|Homo sapiens protocadherin alpha 9 p... 102 9e-21
AY563166-1|AAT72166.1| 1079|Homo sapiens cadherin 23 isoform B2 ... 102 9e-21
AY563165-1|AAT72165.1| 1114|Homo sapiens cadherin 23 isoform B1 ... 102 9e-21
AJ007610-1|CAC22257.1| 950|Homo sapiens protocadherin alpha 9 p... 102 9e-21
AF217743-1|AAK51611.1| 734|Homo sapiens protocadherin-psi2 prot... 102 9e-21
AF152487-1|AAD43748.1| 842|Homo sapiens protocadherin alpha 9 s... 102 9e-21
AF152317-1|AAD43711.1| 950|Homo sapiens protocadherin alpha 9 p... 102 9e-21
AC005609-5|AAC34313.1| 842|Homo sapiens KIAA0345-like 5 protein. 102 9e-21
AB002343-1|BAA20803.2| 845|Homo sapiens KIAA0345 protein. 102 9e-21
AY358428-1|AAQ88794.1| 1184|Homo sapiens PCDH12 protein. 102 1e-20
AF152501-1|AAD43762.2| 801|Homo sapiens protocadherin beta 8 pr... 102 1e-20
BC103928-1|AAI03929.1| 810|Homo sapiens protocadherin gamma sub... 101 2e-20
BC101805-1|AAI01806.1| 811|Homo sapiens protocadherin gamma sub... 101 2e-20
AF152518-1|AAD43778.1| 811|Homo sapiens protocadherin gamma B2 ... 101 2e-20
AF152513-1|AAD43773.1| 818|Homo sapiens protocadherin gamma A6 ... 101 2e-20
AF152486-1|AAD43747.1| 814|Homo sapiens protocadherin alpha 8 s... 101 2e-20
AF152331-1|AAD43725.1| 931|Homo sapiens protocadherin gamma B2 ... 101 2e-20
AF152326-1|AAD43720.1| 932|Homo sapiens protocadherin gamma A6 ... 101 2e-20
AF152316-1|AAD43710.1| 950|Homo sapiens protocadherin alpha 8 p... 101 2e-20
AC005609-6|AAC34318.1| 814|Homo sapiens KIAA0345-like 6 protein. 101 2e-20
AB209178-1|BAD92415.1| 950|Homo sapiens protocadherin gamma sub... 101 2e-20
BC027907-1|AAH27907.1| 924|Homo sapiens protocadherin 20 protein. 100 3e-20
AL592490-1|CAH73802.2| 924|Homo sapiens protocadherin 20 protein. 100 3e-20
AF169693-1|AAF89690.1| 947|Homo sapiens protocadherin 13 protein. 100 3e-20
BC093875-1|AAH93875.1| 850|Homo sapiens protocadherin gamma sub... 100 5e-20
BC093873-1|AAH93873.1| 850|Homo sapiens protocadherin gamma sub... 100 5e-20
AF152503-1|AAD43764.1| 850|Homo sapiens protocadherin gamma A10... 100 5e-20
AF152319-1|AAD43713.1| 936|Homo sapiens protocadherin gamma A10... 100 5e-20
BC130331-1|AAI30332.1| 793|Homo sapiens protocadherin beta 7 pr... 99 6e-20
BC130282-1|AAI30283.1| 1310|Homo sapiens PCLKC protein protein. 99 6e-20
BC115409-1|AAI15410.1| 694|Homo sapiens PCDHGA3 protein protein. 99 6e-20
BC098574-1|AAH98574.1| 793|Homo sapiens protocadherin beta 7 pr... 99 6e-20
AK222560-1|BAD96280.1| 793|Homo sapiens protocadherin beta 7 pr... 99 6e-20
AF217750-1|AAK51617.1| 793|Homo sapiens protocadherin-beta7 pro... 99 6e-20
AF152500-1|AAD43761.1| 793|Homo sapiens protocadherin beta 7 pr... 99 6e-20
AB047004-1|BAB40777.1| 1310|Homo sapiens protocadherin LKC protein. 99 6e-20
L34056-1|AAA35622.1| 796|Homo sapiens cadherin-11 protein. 100 8e-20
BC133708-1|AAI33709.1| 693|Homo sapiens PCDHGA3 protein protein. 100 8e-20
BC115408-1|AAI15409.1| 694|Homo sapiens PCDHGA3 protein protein. 100 8e-20
BC112083-1|AAI12084.1| 878|Homo sapiens protocadherin gamma sub... 100 8e-20
BC112081-1|AAI12082.1| 878|Homo sapiens protocadherin gamma sub... 100 8e-20
AK021915-1|BAB13935.1| 744|Homo sapiens protein ( Homo sapiens ... 100 8e-20
AF152526-1|AAD43786.1| 878|Homo sapiens protocadherin gamma C5 ... 100 8e-20
AF152510-1|AAD43770.1| 829|Homo sapiens protocadherin gamma A3 ... 100 8e-20
AF152339-1|AAD43733.1| 944|Homo sapiens protocadherin gamma C5 ... 100 8e-20
AF152323-1|AAD43717.1| 932|Homo sapiens protocadherin gamma A3 ... 100 8e-20
AB208927-1|BAD92164.1| 961|Homo sapiens protocadherin gamma sub... 100 8e-20
D31784-1|BAA06562.1| 790|Homo sapiens cadherin-6 protein. 99 1e-19
BC130333-1|AAI30334.1| 793|Homo sapiens protocadherin beta 7 pr... 99 1e-19
BC000019-1|AAH00019.1| 663|Homo sapiens CDH6 protein protein. 99 1e-19
AK222678-1|BAD96398.1| 793|Homo sapiens protocadherin beta 7 pr... 99 1e-19
BC026218-1|AAH26218.1| 934|Homo sapiens protocadherin gamma sub... 99 1e-19
BC019299-1|AAH19299.1| 934|Homo sapiens protocadherin gamma sub... 99 1e-19
AF282973-3|AAG10032.1| 536|Homo sapiens protocadherin-beta9 pro... 99 1e-19
AF217749-1|AAF81913.1| 797|Homo sapiens protocadherin beta 9 pr... 99 1e-19
AF152524-1|AAD43784.1| 863|Homo sapiens protocadherin gamma C3 ... 99 1e-19
AF152337-1|AAD43731.1| 934|Homo sapiens protocadherin gamma C3 ... 99 1e-19
AF052685-1|AAC08350.1| 934|Homo sapiens protocadherin 43 protein. 99 1e-19
BC105640-1|AAI05641.1| 797|Homo sapiens protocadherin beta 9 pr... 98 2e-19
BC103494-1|AAI03495.1| 796|Homo sapiens PCDHB9 protein protein. 98 2e-19
AF152502-1|AAD43763.2| 797|Homo sapiens protocadherin beta 9 pr... 98 2e-19
L11373-1|AAA75391.1| 904|Homo sapiens protocadherin 43 protein. 98 2e-19
BC105636-1|AAI05637.1| 797|Homo sapiens protocadherin beta 9 pr... 98 2e-19
BC100672-1|AAI00673.1| 797|Homo sapiens protocadherin beta 9 pr... 98 2e-19
AB006757-1|BAA25196.1| 1200|Homo sapiens PCDH7 (BH-Pcdh)c protein. 98 2e-19
BC113372-1|AAI13373.1| 792|Homo sapiens protocadherin alpha 12 ... 97 4e-19
BC112280-1|AAI12281.1| 792|Homo sapiens protocadherin alpha 12,... 97 4e-19
AF152477-1|AAD43738.1| 792|Homo sapiens protocadherin alpha 12 ... 97 4e-19
AF152308-1|AAD43702.1| 941|Homo sapiens protocadherin alpha 12 ... 97 4e-19
AC005609-2|AAC34315.1| 792|Homo sapiens KIAA0345-like 2 protein. 97 4e-19
BC036674-1|AAH36674.1| 950|Homo sapiens PCDHA6 protein protein. 97 6e-19
AL834254-1|CAD38929.1| 647|Homo sapiens hypothetical protein pr... 97 6e-19
AL122081-1|CAB59256.1| 373|Homo sapiens hypothetical protein pr... 97 6e-19
AF169694-1|AAF89691.1| 695|Homo sapiens protocadherin alpha 6 a... 97 6e-19
AF152484-1|AAD43745.1| 803|Homo sapiens protocadherin alpha 6 s... 97 6e-19
AF152314-1|AAD43708.1| 950|Homo sapiens protocadherin alpha 6 p... 97 6e-19
AC005609-8|AAC34320.1| 803|Homo sapiens KIAA0345-like 8 protein. 97 6e-19
BC113460-1|AAI13461.1| 813|Homo sapiens protocadherin gamma sub... 96 7e-19
BC104926-1|AAI04927.1| 813|Homo sapiens protocadherin gamma sub... 96 7e-19
BC101038-1|AAI01039.1| 871|Homo sapiens protocadherin gamma sub... 96 7e-19
BC101036-1|AAI01037.1| 870|Homo sapiens PCDHGC4 protein protein. 96 7e-19
BC101035-1|AAI01036.1| 871|Homo sapiens protocadherin gamma sub... 96 7e-19
AJ007609-1|CAC22256.1| 949|Homo sapiens protocadherin alpha 11 ... 96 7e-19
AF169695-1|AAF89692.1| 686|Homo sapiens protocadherin alpha 1 a... 96 7e-19
AF152525-1|AAD43785.1| 871|Homo sapiens protocadherin gamma C4 ... 96 7e-19
AF152512-1|AAD43772.1| 813|Homo sapiens protocadherin gamma A5 ... 96 7e-19
AF152479-1|AAD43740.1| 807|Homo sapiens protocadherin alpha 1 s... 96 7e-19
AF152476-1|AAD43737.1| 810|Homo sapiens protocadherin alpha 11 ... 96 7e-19
AF152338-1|AAD43732.1| 938|Homo sapiens protocadherin gamma C4 ... 96 7e-19
AF152325-1|AAD43719.1| 931|Homo sapiens protocadherin gamma A5 ... 96 7e-19
AF152307-1|AAD43701.1| 949|Homo sapiens protocadherin alpha 11 ... 96 7e-19
AF152305-1|AAD43699.1| 950|Homo sapiens protocadherin alpha 1 p... 96 7e-19
AC005609-13|AAC34325.1| 807|Homo sapiens KIAA0345-like 13 protein. 96 7e-19
AC005609-3|AAC34316.1| 810|Homo sapiens KIAA0345-like 3 protein. 96 7e-19
BC117520-1|AAI17521.1| 669|Homo sapiens CDH5 protein protein. 96 1e-18
BC096365-1|AAH96365.1| 662|Homo sapiens CDH5 protein protein. 96 1e-18
BC096364-1|AAH96364.3| 669|Homo sapiens CDH5 protein protein. 96 1e-18
BC096363-1|AAH96363.1| 669|Homo sapiens CDH5 protein protein. 96 1e-18
AF217752-1|AAK51619.1| 794|Homo sapiens protocadherin-beta6 pro... 96 1e-18
AF152499-1|AAD43760.1| 794|Homo sapiens protocadherin beta 6 pr... 96 1e-18
X79981-1|CAA56306.1| 784|Homo sapiens VE-cadherin protein. 95 2e-18
BC099728-1|AAH99728.1| 798|Homo sapiens protocadherin beta 14 p... 95 2e-18
BC098144-1|AAH98144.1| 797|Homo sapiens PCDHB14 protein protein. 95 2e-18
AF217744-1|AAK51612.1| 798|Homo sapiens protocadherin-beta14 pr... 95 2e-18
AF152493-1|AAD43754.1| 798|Homo sapiens protocadherin beta 14 p... 95 2e-18
AB208959-1|BAD92196.1| 716|Homo sapiens protocadherin beta 9 pr... 95 2e-18
AB035304-1|BAA87418.1| 784|Homo sapiens cadherin-5 protein. 95 2e-18
BC104950-1|AAI04951.1| 823|Homo sapiens protocadherin gamma sub... 95 2e-18
BC093871-1|AAH93871.1| 823|Homo sapiens protocadherin gamma sub... 95 2e-18
AF152508-1|AAD43769.1| 823|Homo sapiens protocadherin gamma A2 ... 95 2e-18
AF152322-1|AAD43716.1| 932|Homo sapiens protocadherin gamma A2 ... 95 2e-18
BC113416-1|AAI13417.1| 799|Homo sapiens cadherin 8, type 2 prot... 94 3e-18
AB035305-1|BAA87419.1| 799|Homo sapiens cadherin-8 protein. 94 3e-18
BC098575-1|AAH98575.1| 798|Homo sapiens protocadherin beta 2 pr... 94 4e-18
BC098347-1|AAH98347.1| 798|Homo sapiens protocadherin beta 2, p... 94 4e-18
BC011570-1|AAH11570.1| 530|Homo sapiens cadherin-like 23 protein. 94 4e-18
AY358617-1|AAQ88980.1| 530|Homo sapiens CDH23 protein. 94 4e-18
AL360214-1|CAM21534.1| 718|Homo sapiens protocadherin 15 protein. 94 4e-18
AL356114-1|CAM15115.1| 718|Homo sapiens protocadherin 15 protein. 94 4e-18
AF217756-1|AAK51623.1| 798|Homo sapiens protocadherin-beta2 pro... 94 4e-18
AF152495-1|AAD43756.1| 798|Homo sapiens protocadherin beta 2 pr... 94 4e-18
L34060-1|AAA35628.1| 793|Homo sapiens cadherin-8 protein. 93 5e-18
L34057-1|AAA35623.1| 794|Homo sapiens cadherin-12 protein. 93 5e-18
BC130447-1|AAI30448.1| 685|Homo sapiens protocadherin alpha 10 ... 93 5e-18
BC047608-1|AAH47608.1| 794|Homo sapiens cadherin 12, type 2 (N-... 93 5e-18
AF152475-1|AAD43736.1| 844|Homo sapiens protocadherin alpha 10 ... 93 5e-18
AF152306-1|AAD43700.1| 948|Homo sapiens protocadherin alpha 10 ... 93 5e-18
AC005609-4|AAC34317.1| 844|Homo sapiens KIAA0345-like 4 protein. 93 5e-18
AB209745-1|BAD92982.1| 784|Homo sapiens protocadherin beta 2 pr... 93 5e-18
L33477-1|AAB48539.1| 794|Homo sapiens Br-cadherin protein. 93 7e-18
BC113745-1|AAI13746.1| 789|Homo sapiens cadherin 9, type 2, pre... 93 7e-18
BC107594-1|AAI07595.1| 789|Homo sapiens cadherin 9, type 2 (T1-... 93 7e-18
AF282973-1|AAG10031.1| 610|Homo sapiens protocadherin-beta8 pro... 93 7e-18
AF169689-1|AAF89329.1| 685|Homo sapiens protocadherin alpha 10 ... 93 7e-18
AB035302-1|BAA87416.1| 789|Homo sapiens cadherin-9 protein. 93 7e-18
X59796-1|CAA42468.1| 780|Homo sapiens cadherin-5 protein. 93 9e-18
U84722-1|AAB41796.1| 784|Homo sapiens vascular endothelial cadh... 93 9e-18
AB209908-1|BAD93145.1| 807|Homo sapiens cadherin 5, type 2 prep... 93 9e-18
AF152473-1|AAD43734.1| 818|Homo sapiens protocadherin alpha C1 ... 92 1e-17
AF152303-1|AAD43697.1| 963|Homo sapiens protocadherin alpha C1 ... 92 1e-17
U59325-1|AAB02933.1| 790|Homo sapiens cadherin-14 protein. 92 2e-17
AF039747-1|AAD44017.1| 788|Homo sapiens cadherin-10 protein. 92 2e-17
AB035303-1|BAA87417.1| 788|Homo sapiens cadherin-10 protein. 92 2e-17
D83542-1|BAA12012.1| 814|Homo sapiens cadherin-15 protein. 91 2e-17
BC105111-1|AAI05112.1| 884|Homo sapiens protocadherin alpha sub... 91 2e-17
BC104776-1|AAI04777.1| 884|Homo sapiens protocadherin alpha sub... 91 2e-17
BC063288-1|AAH63288.1| 1007|Homo sapiens protocadherin alpha sub... 91 2e-17
BC028165-1|AAH28165.1| 1159|Homo sapiens protocadherin 17 protein. 91 2e-17
BC008951-1|AAH08951.1| 814|Homo sapiens cadherin 15, M-cadherin... 91 2e-17
AL445288-1|CAI17092.1| 1159|Homo sapiens protocadherin 17 protein. 91 2e-17
AL445216-1|CAH71250.1| 1159|Homo sapiens protocadherin 17 protein. 91 2e-17
AF152474-1|AAD43735.1| 884|Homo sapiens protocadherin alpha C2 ... 91 2e-17
AF152304-1|AAD43698.1| 1007|Homo sapiens protocadherin alpha C2 ... 91 2e-17
AF217748-1|AAK51616.1| 800|Homo sapiens protocadherin-beta10 pr... 91 3e-17
AF135156-1|AAG43278.1| 260|Homo sapiens D-cadherin precursor pr... 91 3e-17
BC031837-1|AAH31837.1| 800|Homo sapiens protocadherin beta 10 p... 91 4e-17
AY358720-1|AAQ89082.1| 800|Homo sapiens PCDHB10 protein. 91 4e-17
AF152489-1|AAD43750.1| 800|Homo sapiens protocadherin beta 10 p... 91 4e-17
BC003126-1|AAH03126.1| 808|Homo sapiens protocadherin alpha 2 p... 90 6e-17
AF152480-1|AAD43741.1| 824|Homo sapiens protocadherin alpha 2 s... 90 6e-17
AF152310-1|AAD43704.1| 948|Homo sapiens protocadherin alpha 2 p... 90 6e-17
AC005609-12|AAC34324.1| 824|Homo sapiens KIAA0345-like 12 protein. 90 6e-17
AY358199-1|AAQ88566.1| 781|Homo sapiens CDH24 protein. 89 1e-16
AY260900-1|AAP20590.1| 781|Homo sapiens cadherin-24 protein. 89 1e-16
AJ007608-1|CAC22255.1| 963|Homo sapiens protocadherin alpha-C1 ... 89 1e-16
BC108254-1|AAI08255.1| 445|Homo sapiens CDH23 protein protein. 89 1e-16
BC036025-1|AAH36025.1| 1070|Homo sapiens protocadherin 8 protein. 89 1e-16
AY260901-1|AAP20591.1| 819|Homo sapiens cadherin-24 variant pro... 89 1e-16
AY013873-1|AAK21986.1| 973|Homo sapiens protocadherin ARCADLIN ... 89 1e-16
AL139085-5|CAI14111.1| 973|Homo sapiens protocadherin 8 protein. 89 1e-16
AL139085-4|CAI14110.1| 1070|Homo sapiens protocadherin 8 protein. 89 1e-16
AK057922-1|BAB71613.1| 493|Homo sapiens protein ( Homo sapiens ... 89 1e-16
AF061573-1|AAC70009.2| 1070|Homo sapiens protocadherin protein. 89 1e-16
Z35402-1|CAA84586.1| 827|Homo sapiens E-cadherin protein. 88 3e-16
Z18923-1|CAA79356.1| 882|Homo sapiens E-cadherin protein. 88 3e-16
Z13009-1|CAA78353.1| 882|Homo sapiens E-cadherin protein. 88 3e-16
L08599-1|AAA61259.1| 878|Homo sapiens uvomorulin protein. 88 3e-16
DQ090940-1|AAY68225.1| 882|Homo sapiens cadherin 1, type 1, E-c... 88 3e-16
BC141838-1|AAI41839.1| 647|Homo sapiens Unknown (protein for MG... 88 3e-16
BC036786-1|AAH36786.1| 630|Homo sapiens CDH7 protein protein. 88 3e-16
AJ007611-1|CAC13127.1| 784|Homo sapiens cadherin-7 protein. 88 3e-16
AF152481-1|AAD43742.1| 824|Homo sapiens protocadherin alpha 3 s... 88 3e-16
AF152311-1|AAD43705.1| 950|Homo sapiens protocadherin alpha 3 p... 88 3e-16
AC005609-11|AAC34323.1| 824|Homo sapiens KIAA0345-like 11 protein. 88 3e-16
AB035301-1|BAA87415.1| 785|Homo sapiens cadherin-7 protein. 88 3e-16
AB025105-1|BAA88956.1| 821|Homo sapiens E-cadherin protein. 88 3e-16
BC139903-1|AAI39904.1| 406|Homo sapiens Unknown (protein for MG... 87 5e-16
BC129807-1|AAI29808.1| 824|Homo sapiens protocadherin alpha 3 p... 87 6e-16
BC069064-1|AAH69064.1| 824|Homo sapiens PCDHA3 protein protein. 86 8e-16
AF029343-1|AAB84144.1| 889|Homo sapiens protocadherin 68 protein. 86 8e-16
BC042650-1|AAH42650.1| 605|Homo sapiens PCDHGC3 protein protein. 85 1e-15
X83929-1|CAA58781.1| 896|Homo sapiens desmocollin type 3 protein. 85 2e-15
D17427-1|BAA04249.1| 896|Homo sapiens desmocollin type 4 protein. 85 2e-15
AF293359-2|AAG23427.1| 839|Homo sapiens desmocollin 3b protein. 85 2e-15
AF293359-1|AAG23426.1| 896|Homo sapiens desmocollin 3a protein. 85 2e-15
AF217751-1|AAK51618.1| 587|Homo sapiens protocadherin-psi1 prot... 85 2e-15
BC031051-1|AAH31051.1| 790|Homo sapiens cadherin 18, type 2 pro... 84 3e-15
AL031687-1|CAB51587.2| 828|Homo sapiens cadherin-like 22 protein. 84 4e-15
AL365496-6|CAM19871.1| 981|Homo sapiens protocadherin 15 protein. 82 2e-14
AL360214-7|CAM21539.1| 981|Homo sapiens protocadherin 15 protein. 82 2e-14
AL356114-8|CAM15121.1| 981|Homo sapiens protocadherin 15 protein. 82 2e-14
AL353784-6|CAM16788.1| 981|Homo sapiens protocadherin 15 protein. 82 2e-14
AK074160-1|BAB84986.1| 535|Homo sapiens FLJ00233 protein protein. 82 2e-14
BC015877-1|AAH15877.1| 390|Homo sapiens CDH19 protein protein. 81 2e-14
AY358654-1|AAQ89017.1| 772|Homo sapiens CDH19 protein. 81 2e-14
AK023785-1|BAB14677.1| 808|Homo sapiens protein ( Homo sapiens ... 81 2e-14
AJ007607-1|CAC13126.1| 772|Homo sapiens cadherin-19 protein. 81 2e-14
BC036470-1|AAH36470.1| 906|Homo sapiens cadherin 2, type 1, N-c... 81 3e-14
AB160984-1|BAD08246.1| 1123|Homo sapiens KIAA0811 protein protein. 81 4e-14
X54315-1|CAA38213.1| 906|Homo sapiens protein ( Human mRNA for ... 80 5e-14
S42303-1|AAB22854.1| 905|Homo sapiens N-cadherin protein. 80 5e-14
M34064-1|AAA03236.1| 747|Homo sapiens NCAD protein. 80 5e-14
X56807-2|CAA40142.1| 914|Homo sapiens desmocollin type 2b protein. 78 2e-13
X56807-1|CAA40141.1| 860|Homo sapiens desmocollin type 2a protein. 78 2e-13
BC112150-1|AAI12151.1| 916|Homo sapiens cadherin 4, type 1, pre... 78 2e-13
BC101651-1|AAI01652.1| 916|Homo sapiens cadherin 4, type 1, R-c... 78 2e-13
BC063291-1|AAH63291.1| 901|Homo sapiens desmocollin 2 protein. 78 2e-13
AL365401-1|CAC26840.2| 916|Homo sapiens cadherin 4, type 1, R-c... 78 2e-13
AL365229-1|CAI16510.1| 916|Homo sapiens cadherin 4, type 1, R-c... 78 2e-13
AL162457-1|CAH73749.1| 916|Homo sapiens cadherin 4, type 1, R-c... 78 2e-13
AL109911-1|CAI19181.1| 916|Homo sapiens cadherin 4, type 1, R-c... 78 2e-13
AK091496-1|BAC03677.1| 824|Homo sapiens protein ( Homo sapiens ... 78 2e-13
AC079298-1|AAY41019.1| 959|Homo sapiens unknown protein. 78 3e-13
X57548-1|CAA40773.1| 748|Homo sapiens N-cadherin protein. 77 4e-13
M76482-1|AAA60230.1| 999|Homo sapiens pemphigus vulgaris antige... 77 4e-13
X83228-1|CAA58231.1| 832|Homo sapiens LI-cadherin protein. 77 5e-13
U07969-1|AAA19021.1| 832|Homo sapiens intestinal peptide-associ... 76 9e-13
BC113464-1|AAI13465.1| 832|Homo sapiens cadherin 17, LI cadheri... 76 9e-13
BC112013-1|AAI12014.1| 832|Homo sapiens cadherin 17, precursor ... 76 9e-13
X63629-1|CAA45177.1| 829|Homo sapiens p-cadherin protein. 75 1e-12
BC051287-1|AAH51287.1| 345|Homo sapiens PCDH1 protein protein. 75 1e-12
BC041846-1|AAH41846.1| 829|Homo sapiens cadherin 3, type 1, P-c... 75 1e-12
BC014462-1|AAH14462.1| 784|Homo sapiens CDH3 protein protein. 75 1e-12
AB074170-1|BAE45735.1| 348|Homo sapiens putative protein produc... 75 1e-12
AY354498-1|AAR10444.1| 702|Homo sapiens protocadherin protein p... 75 2e-12
Z34522-2|CAA84279.1| 894|Homo sapiens Dsc1b precursor protein. 75 3e-12
Z34522-1|CAA84278.1| 840|Homo sapiens Dsc1a precursor protein. 75 3e-12
X72925-2|CAA51429.1| 829|Homo sapiens Dsc1a precursor protein. 75 3e-12
X72925-1|CAA51428.1| 840|Homo sapiens Dsc1b precursor protein. 75 3e-12
AK000054-1|BAA90911.1| 959|Homo sapiens protein ( Homo sapiens ... 75 3e-12
AF293358-2|AAG23425.1| 840|Homo sapiens desmocollin 1b protein. 75 3e-12
AF293358-1|AAG23424.1| 894|Homo sapiens desmocollin 1a protein. 75 3e-12
AF169691-1|AAF89688.1| 398|Homo sapiens cadherin-like protein V... 74 3e-12
X56654-1|CAA39976.1| 1049|Homo sapiens desmoglein type 1 protein. 73 6e-12
AF097935-1|AAC83817.1| 1049|Homo sapiens desmoglein 1 protein. 73 6e-12
L34059-1|AAA35627.1| 916|Homo sapiens cadherin-4 protein. 69 1e-10
BC016722-1|AAH16722.1| 230|Homo sapiens FAT3 protein protein. 69 1e-10
AL137471-1|CAB70755.1| 709|Homo sapiens hypothetical protein pr... 69 1e-10
U59289-1|AAB18912.1| 713|Homo sapiens H-cadherin protein. 69 2e-10
U59288-1|AAB18911.1| 713|Homo sapiens H-cadherin protein. 69 2e-10
L34058-1|AAA35624.1| 713|Homo sapiens cadherin-13 protein. 69 2e-10
AB001103-1|BAA32411.1| 713|Homo sapiens H-cadherin protein. 69 2e-10
BC030653-1|AAH30653.1| 713|Homo sapiens cadherin 13, H-cadherin... 68 2e-10
BC028624-1|AAH28624.1| 713|Homo sapiens cadherin 13, H-cadherin... 68 2e-10
AK027282-1|BAB55016.1| 390|Homo sapiens protein ( Homo sapiens ... 68 3e-10
Z26317-1|CAA81226.1| 1117|Homo sapiens desmoglein 2 protein. 66 7e-10
BC099657-1|AAH99657.1| 1118|Homo sapiens desmoglein 2 protein. 66 7e-10
BC099656-1|AAH99656.1| 1118|Homo sapiens desmoglein 2 protein. 66 7e-10
BC099655-1|AAH99655.1| 1118|Homo sapiens desmoglein 2 protein. 66 7e-10
AF131761-1|AAD20038.1| 420|Homo sapiens Similar to protocadheri... 65 2e-09
D88798-1|BAA21568.1| 140|Homo sapiens cadherin protein. 64 4e-09
AB209205-1|BAD92442.1| 430|Homo sapiens protocadherin alpha 6 i... 64 4e-09
X52279-1|CAA36522.1| 128|Homo sapiens Arc-1/uvomorulin protein. 63 6e-09
BC132909-1|AAI32910.1| 1040|Homo sapiens desmoglein 4 protein. 63 6e-09
BC132907-1|AAI32908.1| 1040|Homo sapiens desmoglein 4 protein. 63 6e-09
AY228236-1|AAP49811.1| 1059|Homo sapiens desmoglein 4 protein. 63 6e-09
AY227350-1|AAP45000.1| 1040|Homo sapiens desmoglein 4 protein. 63 6e-09
AY177664-1|AAO47078.1| 1040|Homo sapiens desmoglein 4 preproprot... 63 6e-09
AY177663-1|AAO47077.1| 1040|Homo sapiens desmoglein 4 preproprot... 63 6e-09
AY168788-1|AAO43657.1| 1059|Homo sapiens desmoglein 4 protein. 63 6e-09
BC109240-1|AAI09241.1| 269|Homo sapiens IL19 protein protein. 63 9e-09
AY388963-1|AAR26468.1| 837|Homo sapiens protocadherin 15 isofor... 62 2e-08
>AY010111-1|AAG27034.2| 3354|Homo sapiens cadherin 23 protein.
Length = 3354
Score = 161 bits (392), Expect = 1e-38
Identities = 140/469 (29%), Positives = 215/469 (45%), Gaps = 25/469 (5%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L + +V VT++D NDN P+F + + + T + ++A+D D G NG V Y
Sbjct: 1614 LSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYA 1673
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAES---PILEGRHALFVEASDQPANPSERRYSLAVV 555
+ + I + F+I+ + G ++ A+ I GR+ L V A+DQ S R S V
Sbjct: 1674 IVAGN---IVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTV 1730
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGS-NVGIGTSVGQIRVNDAFEQNDVSYDLLHGY 614
+ V N P P P+E G + T + R D+ V Y ++ G
Sbjct: 1731 LVNVN-DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDR--DSGPNGQVEYSIMDGD 1787
Query: 615 EEGVPFAVEERSGVITVVDD--LSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVND 671
G F + GV+ V D L R Y+ A LS + V+D+ND
Sbjct: 1788 PLG-EFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDIND 1846
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
VLL + P+ + ENS ++ + H S + F I
Sbjct: 1847 NDPVLL---NLPMNITISENSPVSSF--VAHVLASDADSGCNARLTFNITAGNRERAFFI 1901
Query: 732 IAEDGTIFTQKPLDREKRDVYRMTVIAEFN--KGVISGAGIYQVTIYIEDENDNPPVFEH 789
A G + +PLDRE+ Y++T+ + N I+ + I++ DENDN P+F
Sbjct: 1902 NATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTK 1961
Query: 790 ATYEGFIMENSKIGTEIKMDN-IIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+TY+ +MENS GT + + N I A DAD+ A+ Y L G +FD++ +TGVV
Sbjct: 1962 STYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTV 2021
Query: 849 -IGDSLDRE--KKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFN 894
G +DRE + +L L+A D G L+S A L+I I D+NDN+P F+
Sbjct: 2022 RSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFS 2070
Score = 156 bits (378), Expect = 7e-37
Identities = 254/1016 (25%), Positives = 428/1016 (42%), Gaps = 138/1016 (13%)
Query: 439 LMSFVNVEVTLLDANDNNPVFV--PSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
L S + V + +LD NDN+PV + P N+ ++ N+ V + + V A D D G N +
Sbjct: 1831 LSSTMLVGIRVLDINDNDPVLLNLPMNI---TISENSPVSSFVAHVLASDADSGCNARLT 1887
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR---HALFVEASDQPANP--SERRYS 551
+++ + F IN TG V+V P+ R + L + D P NP + R Y
Sbjct: 1888 FNITAGNR---ERAFFINATTGIVTV-NRPLDRERIPEYKLTISVKDNPENPRIARRDYD 1943
Query: 552 LAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSV----GQIRVNDAFEQ--ND 605
L ++ + + P F + Y+ V N GT + G I DA +
Sbjct: 1944 LLLIFLS------DENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV 1997
Query: 606 VSYDLLHGYEEGVPFAVEERSGVITV----VDDLSRYNRPMYDFEAVALQENANLSIVTN 661
V+Y LL G + G+ F + +GV+TV + D ++ P+ + +A ++ L+ +
Sbjct: 1998 VTYQLL-GAQSGL-FDINSSTGVVTVRSGVIIDREAFSPPILELLLLA-EDIGLLNSTAH 2054
Query: 662 ATVHVVDVNDERGVLLKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLI 720
+ ++D ND R + + + H+ EN G ++ Q+ T+ S G V +
Sbjct: 2055 LLITILDDNDNRPTF---SPATLTVHLLENCPPGFSVLQVTATDEDS--GLNGELVYRIE 2109
Query: 721 ANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDE 780
A QD I + +DRE+++ YR+TV+A ++G + +G VTI I+D
Sbjct: 2110 AGAQD-RFLIHLVTGVIRVGNATIDREEQESYRLTVVAT-DRGTVPLSGTAIVTILIDDI 2167
Query: 781 NDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVD 840
ND+ P F + ++E+++ GT I NI T D N Y + G + D
Sbjct: 2168 NDSRPEFLNPIQTVSVLESAEPGTVIA--NI---TAIDHDLNPKLEYHIVG----IVAKD 2218
Query: 841 ENTGVVKFIGDSLD---REKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIE 897
+ +V D+ +M K S + R+ L + E+ + + D + PE +
Sbjct: 2219 DTDRLVPNQEDAFAVNINTGSVMVK-SPMNRE---LVATYEVTLSVIDNASDLPERSVSV 2274
Query: 898 ENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALD 957
N+K+ ++ + T F KP F + + I E GTT+I + A+D
Sbjct: 2275 PNAKLTVNVLDVNDNTPQF-----KP---FGITYY----MERILEGATPGTTLIAVAAVD 2322
Query: 958 LDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLN- 1016
D GLNG + Y +PP + + + G VI R++ E LN
Sbjct: 2323 PDKGLNGLVTYTLLD--LVPPGYVQLE----------DSSAGKVIANRTVDYEEVHWLNF 2370
Query: 1017 -ISALDGGNLNDNISVRVFVK--DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD 1073
+ A D G+ + V+++ D+ND+ P+F + Y V E ++ V ATDAD
Sbjct: 2371 TVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDAD 2430
Query: 1074 FGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG---XXXX 1130
G A + Y + D + F I+P TG + V LDRE +D YILT +A+DN
Sbjct: 2431 SGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNR 2488
Query: 1131 XXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENA 1190
DVND P+F P+ N + + AT ++
Sbjct: 2489 RENSVQVVIQVLDVNDCRPQF---------SKPQFSTSVYENEPAGTSVITMMATDQDEG 2539
Query: 1191 PIGTTVAKVFANDTD--FIGNGNGLILYSLPQRKNQQ--------NLGLPSLSSTAILMV 1240
P G + + + +GL+ P + ++ + G P L T +L+V
Sbjct: 2540 PNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLV 2599
Query: 1241 TVADVPDEVEMSDKPVFI--SRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILN 1296
V DV D ++PVF+ L I E + + + T+ E N +RY L
Sbjct: 2600 EVIDVND-----NRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLK 2654
Query: 1297 ENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVL 1356
F+IDP +G + + DRE + Y +I+ A + PV + +
Sbjct: 2655 TAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS---------DLGQPVPYETM 2705
Query: 1357 EGMTKYDVKVVVRIKDVNDNSPKFT----NGNRPLVTAIPTTAPFGYQVMQLKGAI 1408
+ + V ++D++DN P F + + +P +P G V + GA+
Sbjct: 2706 QPLQ-------VALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAV 2754
Score = 152 bits (369), Expect = 8e-36
Identities = 257/1011 (25%), Positives = 406/1011 (40%), Gaps = 135/1011 (13%)
Query: 432 IEYYDEQL---MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPD 488
+E Y+ L S V V V + D ND PVF ++ A +GT + V+A D D
Sbjct: 1178 VEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRD 1237
Query: 489 LGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPS 546
G G+V Y + + F+I+ +TG + E + + + V A+DQ A P
Sbjct: 1238 SGDGGLVNYRILSGAE----GKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQ-APPF 1292
Query: 547 ERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDV 606
+ + +T+ + F A YE + N+ +GT + +++ N +
Sbjct: 1293 NQGFCSVYITL------LNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQI 1346
Query: 607 SY--DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
+Y D + F ++ +GVITV + R Y VA + +
Sbjct: 1347 TYRFDAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYI 1406
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGT-GNVRFLIANQ 723
V+D ND + S + + E+ +GQ T + G+ G V F +A+
Sbjct: 1407 TVLDENDNSPRFDFTSDSAV--SIPED---CPVGQRVATVKAWDPDAGSNGQVVFSLASG 1461
Query: 724 QDV-TDDIAIAED--GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDE 780
+I D G +F +PLDRE+ D Y + V+A ++G + + + I D
Sbjct: 1462 NIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVAS-DRGTPPRKKDHILQVTILDI 1520
Query: 781 NDNPPVFEHAT-YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM-FD 838
NDNPPV E Y + EN GT + ++ATD D G N++ Y + K+M F
Sbjct: 1521 NDNPPVIESPFGYNVSVNENVGGGTAVVQ---VRATDRDIGINSVLSYYITEGNKDMTFR 1577
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQI 896
+D +G + DRE++ Y L D G LS+ + + I DENDN P F Q
Sbjct: 1578 MDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQ- 1636
Query: 897 EENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNAL 956
+ +V + T+ TI ALD+D+ GP + I G + N
Sbjct: 1637 -PHYEVLLDEGPDTLNTSLITI--------QALDLDE-GPNGTVTYAIVAGNIV---NTF 1683
Query: 957 DLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLN 1016
+D + G I +A L+ Y + + R+ ++ A P RL
Sbjct: 1684 RIDRHM-GVI--------------TAAKELD---YEISHGRYTLIVTATDQCPILSHRLT 1725
Query: 1017 ISALDGGNLND-NISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFG 1075
+ N+ND N +V F +D F V E Q RV + A D D G
Sbjct: 1726 STTTVLVNVNDINDNVPTFPRDYEG----------PFEVTEGQPGPRVWTFL-AHDRDSG 1774
Query: 1076 QNANLTYFIQPSDTDLPFEISPLTGVLSV--NGELDRETEDKYILTVVARDNGXXXXXXX 1133
N + Y I D F ISP+ GVL V + ELDRET Y LT+ ARD G
Sbjct: 1775 PNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRG-MPPLSS 1833
Query: 1134 XXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIG 1193
D+NDN P ++ +P+ TI EN+P+
Sbjct: 1834 TMLVGIRVLDINDNDP-------------------------VLLNLPM-NITISENSPVS 1867
Query: 1194 TTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPD---EVE 1250
+ VA V A+D D N + R+ + + T + +P+ +
Sbjct: 1868 SFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTIS 1927
Query: 1251 MSDKPV---FISRYYELEI----EENVNAPVELVSLNLTEHYENFK--MRYYILN----- 1296
+ D P R Y+L + +EN N P+ S E EN +LN
Sbjct: 1928 VKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILA 1987
Query: 1297 -ENDTDIRR--TFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAE 1353
+ D DI T+ + L+ + S V VI+ +R+ +S + ++ +AE
Sbjct: 1988 LDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVII--DREAFSPPILELLL-LAE 2044
Query: 1354 DVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQL 1404
D+ G+ +++ I D NDN P F+ L + P G+ V+Q+
Sbjct: 2045 DI--GLLNSTAHLLITILDDNDNRPTFSPAT--LTVHLLENCPPGFSVLQV 2091
Score = 143 bits (346), Expect = 5e-33
Identities = 215/799 (26%), Positives = 316/799 (39%), Gaps = 125/799 (15%)
Query: 403 WRRQPLETNAPLEKTT-YVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVP 461
W RQPL+ E T + D G T VN++V D NDN P F
Sbjct: 88 WLRQPLDRETKSEFTVEFSVSDHQGVITRK-----------VNIQVG--DVNDNAPTF-H 133
Query: 462 SNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVS 521
+ Y + N VGT I V A DPDLG G VLY Q S F I+ G V+
Sbjct: 134 NQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF-----FAIDSARGIVT 188
Query: 522 VAESPILEGRHA--LFVEASDQP-ANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPY 578
V E A L V A+DQ P +LA++ +V + P F+ PY
Sbjct: 189 VIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV-------QDMDPIFINLPY 241
Query: 579 EFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLS 636
+ + GT+V I D + Y ++ G + FA++ SGV+T+ L
Sbjct: 242 STNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSI-FALDYISGVLTLNGLLD 300
Query: 637 RYNRPMYDFEAVALQENANLS---------IVTNATVHVVDVNDERGVLLKGAHSPIIFH 687
R N P+Y + + L+ + T + V+D+ND +S I
Sbjct: 301 REN-PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITE 359
Query: 688 VKENSAGAAIG-QIFH-------TNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIF 739
+ + + Q+ +M +Y G + F+I+ + D I
Sbjct: 360 LAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIIS-----PTSVQGKADIRIR 414
Query: 740 TQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMEN 799
PLD E D Y + A N+ V G +V I + +ENDN P+F Y + EN
Sbjct: 415 VAIPLDYETVDRYDFDLFA--NESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYEN 472
Query: 800 SKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKI 859
+GT + + ATD D GT FGE V F D DR
Sbjct: 473 VTVGTSVLT---VLATDNDAGT--------FGE------------VSYFFSDDPDR---- 505
Query: 860 MYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTII 919
+ L +DTG LI++I + ++ I+ + I R+ T G I
Sbjct: 506 -FSLD---KDTG-------LIMLIA-----RLDYELIQRFTLTIIARDGGGEETTGRVRI 549
Query: 920 EVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPS 979
V N + + + EN P T +++L A D DS N QI Y S
Sbjct: 550 NVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITY----------S 599
Query: 980 KLSADALEVKRYFVINERHGHVIVARSLPPESE------FRLNISALDGGN--LNDNISV 1031
+SA A YF I+ G+ +++ S P + E L + A+D GN LN + V
Sbjct: 600 IVSASAFG--SYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPV 657
Query: 1032 RVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDL 1091
+ V D ND+ P F K Y +V E + ++ATD D + I +
Sbjct: 658 TIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST 717
Query: 1092 PFEISPLTGVLSVNGELDRETEDKYILTVVARDNG-XXXXXXXXXXXXXXXXDVNDNSPK 1150
F I+ +G ++ LDRET+ +YIL V A D G D+NDN P
Sbjct: 718 QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
Query: 1151 FY---AFDELLEWKHPEAD 1166
+ + L+E P++D
Sbjct: 778 WKDAPYYINLVEMTPPDSD 796
Score = 118 bits (285), Expect = 1e-25
Identities = 134/498 (26%), Positives = 206/498 (41%), Gaps = 48/498 (9%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
Q V +TLLD NDN+P + + Y ++ + + V AVDPDLG+NG ++Y
Sbjct: 757 QKTGIATVNITLLDINDNHPTWKDAPYY-INLVEMTPPDSDVTTVVAVDPDLGENGTLVY 815
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVA------ESP---ILEGRHALFVEASDQPANPSER 548
+Q + + +N TG + E+P E + V +D P +
Sbjct: 816 SIQPPNKF-----YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTD-CGRPPLK 869
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDV 606
S A V + + N D P F P+ V + G S+ Q+ D E V
Sbjct: 870 ATSSATVFVNL---LDLNDND-PTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLV 925
Query: 607 SYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVH 665
SY + G + F + SGV+ +L R Y VA S + T+H
Sbjct: 926 SYRMPVGMPR-MDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIH 984
Query: 666 VVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTG-NVR---FLIA 721
V+DVNDE P +++V S + + F + N G N F+
Sbjct: 985 VLDVNDETPTFF-----PAVYNV---SVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG 1036
Query: 722 NQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVIS--GAGIYQVTIYIED 779
D + D + T LDRE Y M ++ + G + G V + + D
Sbjct: 1037 GNVDGKFSVGY-RDAVVRTVVGLDRETTAAY-MLILEAIDNGPVGKRHTGTATVFVTVLD 1094
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMY-TLFGEGKEMFD 838
NDN P+F ++YE + E+ G I +KATDADEG Y L G F
Sbjct: 1095 VNDNRPIFLQSSYEASVPEDIPEGHSILQ---LKATDADEGEFGRVWYRILHGNHGNNFR 1151
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVA--RDTGGLSSEAELIIMIGDENDNKPEFNQI 896
+ + G++ LDRE+ + L + A D G + S +I+ + D ND P F Q
Sbjct: 1152 IHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQ- 1210
Query: 897 EENSKVRIHRETKLNGTA 914
++ S++ + RET GT+
Sbjct: 1211 QQYSRLGL-RETAGIGTS 1227
Score = 107 bits (257), Expect = 3e-22
Identities = 125/441 (28%), Positives = 195/441 (44%), Gaps = 37/441 (8%)
Query: 443 VNVEVTLLDANDNNPVF-VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQR 501
+ V + ++D NDNNP+F PS Y+ ++ + VGT+I V A D D G ++ Y L
Sbjct: 2386 IPVYLEIVDINDNNPIFDQPS--YQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGD 2443
Query: 502 TSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPAN-PSERRYSLAVVTIE 558
S F INP TG + V S E + + L A D P + S RR + V I+
Sbjct: 2444 GE-----SKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQ 2498
Query: 559 VTRGTKGNKPDI--PDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGY 614
V +P P F + YE N GTSV + D E +++Y L
Sbjct: 2499 VL-DVNDCRPQFSKPQFSTSVYE-----NEPAGTSVITMMATDQDEGPNGELTYSLEGPG 2552
Query: 615 EEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTNATVHVVDVNDER 673
E F V+ SG++T L Y + + VA L T V V+DVND R
Sbjct: 2553 VEA--FHVDMDSGLVTTQRPLQSYEK--FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNR 2608
Query: 674 GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFL-IANQQDVTDDIAI 732
V ++ + I+ +E + + +++ T+ NG FL A +D I
Sbjct: 2609 PVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGL-NGAVRYSFLKTAGNRDWEFFIID 2667
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH--- 789
G I T + LDRE + VY + ++A + + + + +ED +DN P+F
Sbjct: 2668 PISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPK 2727
Query: 790 --ATYEGF-IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVV 846
Y+ + E+S GT + N+ A DADEG NA+ Y + +E + G +
Sbjct: 2728 GSPQYQLLTVPEHSPRGTLV--GNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCL 2785
Query: 847 KFIGDSLDREKKIMYKLSLVA 867
+ D LDRE++ ++ + A
Sbjct: 2786 LVLRD-LDREREAIFSFIVKA 2805
Score = 105 bits (252), Expect = 1e-21
Identities = 122/457 (26%), Positives = 197/457 (43%), Gaps = 29/457 (6%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLT 506
+ +LD ND P F P+ +Y S+ + + + D D+G N + Y + +
Sbjct: 983 IHVLDVNDETPTFFPA-VYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFI---TGGN 1038
Query: 507 ITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIEVTRGTK 564
+ F + V E + L +EA D P +R++
Sbjct: 1039 VDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDN--GPVGKRHTGTATVFVTVLDVN 1096
Query: 565 GNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQN--DVSYDLLHGYEEGVPFAV 622
N+P F+ + YE V ++ G S+ Q++ DA E V Y +LHG G F +
Sbjct: 1097 DNRPI---FLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHG-NHGNNFRI 1152
Query: 623 EERSGVITVVD---DLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKG 679
+G++ D R + + EA S V V+V D+NDE V +
Sbjct: 1153 HVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSV-RVIVYVEDINDEAPVFTQQ 1211
Query: 680 AHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTI 738
+S + ++E + G ++ + T+ S G+G G V + I + + +I G I
Sbjct: 1212 QYSRL--GLRETAGIGTSVIVVQATDRDS--GDG-GLVNYRILSGAEGKFEID-ESTGLI 1265
Query: 739 FTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIME 798
T LD E + Y M V A ++ G V I + +E D F +A+YE I+E
Sbjct: 1266 ITVNYLDYETKTSYMMNVSAT-DQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILE 1324
Query: 799 NSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKK 858
N +GTEI + ++ T YT + K +F +D TGV+ G +DREK
Sbjct: 1325 NLALGTEIVRVQAYSIDNLNQITYRFDAYT-STQAKALFKIDAITGVITVQG-LVDREKG 1382
Query: 859 IMYKLSLVARDTG-GLSSEAELIIMIGDENDNKPEFN 894
Y L++VA D G + S ++ I + DENDN P F+
Sbjct: 1383 DFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFD 1419
Score = 105 bits (251), Expect = 2e-21
Identities = 118/439 (26%), Positives = 185/439 (42%), Gaps = 33/439 (7%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
S V V LLD NDN+P F NL + + G I +V A+D D G NG+V Y
Sbjct: 872 SSATVFVNLLDLNDNDPTF--QNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSY-- 927
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTI 557
R F IN ++G V E + L V ASD +L + +
Sbjct: 928 -RMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVL 986
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYE 615
+V T P F A Y V +V V + ND ++SY + G
Sbjct: 987 DVNDET-------PTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNV 1039
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQEN-ANLSIVTNATVHV--VDVNDE 672
+G F+V R V+ V L R Y A+ ATV V +DVND
Sbjct: 1040 DG-KFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDN 1098
Query: 673 RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI 732
R + L+ ++ + ++ G +I Q+ T+ G V + I + +
Sbjct: 1099 RPIFLQSSYEASV--PEDIPEGHSILQLKATDADE---GEFGRVWYRILHGNHGNNFRIH 1153
Query: 733 AEDGTIFT-QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
+G + +PLDRE+ + + ++ +N + +V +Y+ED ND PVF
Sbjct: 1154 VSNGLLMRGPRPLDRERNSSH-VLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQ 1212
Query: 792 YEGF-IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIG 850
Y + E + IGT + +++ATD D G L Y + + F++DE+TG++ +
Sbjct: 1213 YSRLGLRETAGIGTSVI---VVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITV- 1268
Query: 851 DSLDREKKIMYKLSLVARD 869
+ LD E K Y +++ A D
Sbjct: 1269 NYLDYETKTSYMMNVSATD 1287
Score = 104 bits (249), Expect = 3e-21
Identities = 91/334 (27%), Positives = 155/334 (46%), Gaps = 24/334 (7%)
Query: 71 GAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSL 128
G G NQ + +V + + D+NDN P + D PY++ + E+TP + + + P +G +
Sbjct: 752 GVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENG 811
Query: 129 TIPLTVPRGLTIFK------DIRA----FDRDKPNTPNSDVHYSIV-SGNDDGHFALESS 177
T+ ++ + IR DR+ P+ +++ IV S D G L+++
Sbjct: 812 TLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKAT 871
Query: 178 HKPVLLLRKVLDYDAGDKEFQ-LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELI 236
+ + +LD + D FQ L +A + + AID D G+ + Y +
Sbjct: 872 SSATVFVN-LLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP 930
Query: 237 SGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
G R F ++S +G + ELD + Q L+V AS P K++ + + I +
Sbjct: 931 VGMPRMDFLINSSSGVVVTTTELDRERIAEYQ-----LRVVASDAGTPTKSSTSTLTIHV 985
Query: 297 LDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSI 354
LD+ND P F YN+S+ E++P F V+ + TD D G N E +Y + + G FS+
Sbjct: 986 LDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSV 1045
Query: 355 DPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
R VR LDRE ++ + + A + P
Sbjct: 1046 GYRDA--VVRTVVGLDRETTAAYMLILEAIDNGP 1077
Score = 104 bits (249), Expect = 3e-21
Identities = 106/424 (25%), Positives = 180/424 (42%), Gaps = 22/424 (5%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI--APIGPSLTI 130
G+ +S+ + V + + D+NDN P+ L+ P ++T+ E +P L A G + +
Sbjct: 1827 GMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARL 1886
Query: 131 PLTVPRG-------LTIFKDIRAFDR--DKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
+ G + I +R D+ P + S+ ++ A +
Sbjct: 1887 TFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
Query: 182 LLLRKVLDYDA--GDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGN 239
+ L D +Q +M + + PI A+D D + A + Y+L+ G
Sbjct: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GA 2005
Query: 240 DRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
LF ++S G + + + +D E L + A + L + A + I +LD
Sbjct: 2006 QSGLFDINSSTGVVTVRSGVIIDREA-FSPPILELLLLAEDIG--LLNSTAHLLITILDD 2062
Query: 300 NDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD-DPKGAFSIDPRS 358
NDN P F + ++EN P GFSVLQV ATD+D G NGE Y+++ + F I +
Sbjct: 2063 NDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVT 2122
Query: 359 GWLTVRNQTVLDREAHSSLRMKVYAKETNP-SVVGTFADSQRIAKWRRQPLETNAPLEKT 417
G + V N T+ DRE S R+ V A + + GT + I E P++
Sbjct: 2123 GVIRVGNATI-DREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTV 2181
Query: 418 TYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGT 477
+ + + GT NI D L + + + A D+ VP+ F++ N G+
Sbjct: 2182 SVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAV--NINTGS 2239
Query: 478 VIGK 481
V+ K
Sbjct: 2240 VMVK 2243
Score = 101 bits (242), Expect = 2e-20
Identities = 135/518 (26%), Positives = 204/518 (39%), Gaps = 65/518 (12%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN T TI EV +N + + ENI G T++ LNA DLD Y
Sbjct: 651 LNSTVPVTI-EVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSR----EYG 705
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG---N 1024
S +Y +LE F IN R G + L E SE+ L + A+DGG N
Sbjct: 706 QESIIY---------SLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHN 756
Query: 1025 LNDNI-SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYF 1083
I +V + + D+ND+ P +K Y N+ E + V A D D G+N L Y
Sbjct: 757 QKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS 816
Query: 1084 IQPSDTDLPFEISPLTG-VLSVNGELDRETEDKY------ILTVVARDNGX-XXXXXXXX 1135
IQP + + ++ TG + + + LDRE D + + V D G
Sbjct: 817 IQPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 874
Query: 1136 XXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTT 1195
D+NDN P F + E +S + ++ + + P+G
Sbjct: 875 TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMP 934
Query: 1196 VAKVFANDTDFIG------NGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEV 1249
N + + + + Y L R + G P+ SST+ L + V DV DE
Sbjct: 935 RMDFLINSSSGVVVTTTELDRERIAEYQL--RVVASDAGTPTKSSTSTLTIHVLDVNDET 992
Query: 1250 EMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV 1307
P F Y + + E+V +V LN T++ N ++ Y+I N + F
Sbjct: 993 -----PTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGN---VDGKFS 1044
Query: 1308 IDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVV 1367
+ R+ + V DRE Y +I+ A PV + T V
Sbjct: 1045 VGYRDAVVRTVVGLDRETTAAYMLILEAIDNG----------PVGKRHTGTAT-----VF 1089
Query: 1368 VRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQLK 1405
V + DVNDN P F + ++P P G+ ++QLK
Sbjct: 1090 VTVLDVNDNRPIFLQSS--YEASVPEDIPEGHSILQLK 1125
Score = 101 bits (241), Expect = 3e-20
Identities = 120/487 (24%), Positives = 199/487 (40%), Gaps = 44/487 (9%)
Query: 427 TKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVD 486
T T+ +L S V V + D NDN P F F + + + G + A D
Sbjct: 1712 TATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEV-TEGQPGPRVWTFLAHD 1770
Query: 487 PDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVE----ASDQP 542
D G NG V Y + L F I+P G + V + L+ F A D+
Sbjct: 1771 RDSGPNGQVEYSIMDGDPL---GEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRG 1827
Query: 543 ANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE 602
P + + +++ N D P + P + N + + V + +DA
Sbjct: 1828 MPPLSSTMLVGIRVLDI------NDND-PVLLNLPMNITISENSPVSSFVAHVLASDADS 1880
Query: 603 QND--VSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT 660
+ +++++ G E F + +G++TV L R P Y N I
Sbjct: 1881 GCNARLTFNITAGNRERA-FFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIAR 1939
Query: 661 N----ATVHVVDVNDERGVLLKGAHSPIIFHVKENS-AGAAI----GQIFHTNMSS-IYG 710
+ + D ND + K + V ENS AG + G I + IY
Sbjct: 1940 RDYDLLLIFLSDENDNHPLFTKSTYQA---EVMENSPAGTPLTVLNGPILALDADQDIYA 1996
Query: 711 NGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDRE--KRDVYRMTVIAEFNKGVISGA 768
T + + D+ + T+ + +DRE + + ++AE + G+++
Sbjct: 1997 VVTYQLLGAQSGLFDINSSTGVV---TVRSGVIIDREAFSPPILELLLLAE-DIGLLNST 2052
Query: 769 GIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYT 828
+TI D+NDN P F AT ++EN G + + ATD D G N +Y
Sbjct: 2053 AHLLITIL--DDNDNRPTFSPATLTVHLLENCPPGFSVLQ---VTATDEDSGLNGELVYR 2107
Query: 829 LFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDE 886
+ ++ F + TGV++ ++DRE++ Y+L++VA D G LS A + I+I D
Sbjct: 2108 IEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDI 2167
Query: 887 NDNKPEF 893
ND++PEF
Sbjct: 2168 NDSRPEF 2174
Score = 98.7 bits (235), Expect = 1e-19
Identities = 176/726 (24%), Positives = 285/726 (39%), Gaps = 85/726 (11%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGK-VKAVDPD--LGQNGMV-LYDLQRT 502
+ ++D NDN P F S Y ++ A+VG + ++ VD D LG N M +Y +
Sbjct: 336 ILVIDINDNAPEFNSSE-YSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNN 394
Query: 503 SNLTITSPFKINPNTGT-VSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTR 561
S+ I SP + + VA E + + P Y+ +T+
Sbjct: 395 SHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINEN 454
Query: 562 GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVP 619
+ P F Y + NV +GTSV + NDA +VSY +
Sbjct: 455 DNR------PIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR--- 505
Query: 620 FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKG 679
F++++ +G+I ++ L + +A ++ ++V+DVND K
Sbjct: 506 FSLDKDTGLIMLIARLDYELIQRFTLTIIA-RDGGGEETTGRVRINVLDVNDNVPTFQKD 564
Query: 680 AHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTD--DIAIAED-G 736
A+ + ++EN ++ Q+ + + + I + DI++ E G
Sbjct: 565 AY---VGALRENEP--SVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYG 619
Query: 737 TIFTQKPLDREK--RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEG 794
I +PLD E+ + +TV+A + G VTI + DENDNPP F Y
Sbjct: 620 VISVSRPLDYEQISNGLIYLTVMA-MDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFV 678
Query: 795 FIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLD 854
++EN G + N + E +Y+L EG F ++ +G + LD
Sbjct: 679 SVVENIMAGATVLFLNATDLDRSREYGQESIIYSL--EGSTQFRINARSGEITTTS-LLD 735
Query: 855 REKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTA 914
RE K SE LI+ D + N K I T
Sbjct: 736 RETK----------------SEYILIVRAVDGG--------VGHNQKTGI-------ATV 764
Query: 915 GFTIIEVKPKNKFALDVDQLGPLFL-IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
T++++ + D P ++ + E P + + + A+D D G NG + Y
Sbjct: 765 NITLLDINDNHPTWKDA----PYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ-- 818
Query: 974 VYIPPSKL-SADALEVKRYFVINERHGHVIVARSLPPESEF--RLNISALDGGN--LNDN 1028
PP+K S ++ K I H + P E+E ++ +S D G L
Sbjct: 819 ---PPNKFYSLNSTTGK----IRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKAT 871
Query: 1029 ISVRVFVK--DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQP 1086
S VFV D+ND+ P F+ + V E + +V A D D G N ++Y +
Sbjct: 872 SSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPV 931
Query: 1087 SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+ F I+ +GV+ ELDRE +Y L VVA D G DVND
Sbjct: 932 GMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAG-TPTKSSTSTLTIHVLDVND 990
Query: 1147 NSPKFY 1152
+P F+
Sbjct: 991 ETPTFF 996
Score = 97.1 bits (231), Expect = 4e-19
Identities = 117/419 (27%), Positives = 173/419 (41%), Gaps = 53/419 (12%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
E IP G +I ++ A+DLD GLNG + Y V +P + F+IN G V
Sbjct: 901 EGIPAGVSIYQVVAIDLDEGLNGLVSYRM--PVGMP-----------RMDFLINSSSGVV 947
Query: 1002 IVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ L E +E++L + A D G + ++ + V DVND P F YN +V E
Sbjct: 948 VTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSED 1007
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYI 1117
+ ++ TD D G NA L+YFI + D F + V+ LDRET Y+
Sbjct: 1008 VPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYM 1067
Query: 1118 LTVVARDNG-XXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESV 1176
L + A DNG DVNDN P F E PE D H S+
Sbjct: 1068 LILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIF--LQSSYEASVPE-DIPEGH---SI 1121
Query: 1177 MMIPVYKATIEENAPIGTTVAKVFAND--TDF-IGNGNGLILYS---LPQRKNQQ----- 1225
+ + KAT + G ++ + +F I NGL++ L + +N
Sbjct: 1122 LQL---KATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIV 1178
Query: 1226 ---NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYY-ELEIEENVNAPVELVSLNL 1281
N L + S+ ++V V D+ DE PVF + Y L + E ++ +
Sbjct: 1179 EAYNHDLGPMRSSVRVIVYVEDINDEA-----PVFTQQQYSRLGLRETAGIGTSVIVVQA 1233
Query: 1282 TEH--YENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
T+ + + Y IL + F ID G + V D E K +Y + V A Q
Sbjct: 1234 TDRDSGDGGLVNYRIL----SGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQ 1288
Score = 95.5 bits (227), Expect = 1e-18
Identities = 131/529 (24%), Positives = 222/529 (41%), Gaps = 58/529 (10%)
Query: 440 MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
+ + V++TL++ NDN P+F LY S+ N VGT + V A D D G G V Y
Sbjct: 441 VGYAKVKITLINENDNRPIF-SQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF 499
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTI 557
+ F ++ +TG + + E R L + A D + R + V+ +
Sbjct: 500 SDDPD-----RFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDV 554
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYE 615
++P F Y + N T + ++R D+ N ++Y ++
Sbjct: 555 ---------NDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASA 605
Query: 616 EGVPFAVE--ERSGVITVVD--DLSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVDVN 670
G F + E GVI+V D + + + +A+ N L+ T+ V D N
Sbjct: 606 FGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDEN 665
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
D K A+ + V+ AGA + + T++ G ++ I + + T
Sbjct: 666 DNPPTFSKPAY--FVSVVENIMAGATVLFLNATDLDRSREYGQESI---IYSLEGSTQFR 720
Query: 731 AIAEDGTIFTQKPLDREKRDVYRMTVIA-EFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
A G I T LDRE + Y + V A + G GI V I + D NDN P ++
Sbjct: 721 INARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKD 780
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFI 849
A Y ++E + +++ + A D D G N +Y++ K + ++ TG ++
Sbjct: 781 APYYINLVEMTPPDSDV---TTVVAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTT 836
Query: 850 GDSLDREK------KIMYKLSLVARDTG----GLSSEAELIIMIGDENDNKPEFNQIEEN 899
LDRE ++M K+ + D G +S A + + + D NDN P F +
Sbjct: 837 HAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFV 896
Query: 900 SKVRIHRETKLNG-TAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIG 947
++V L G AG +I +V A+D+D+ G L+ +P+G
Sbjct: 897 AEV-------LEGIPAGVSIYQV-----VAIDLDE-GLNGLVSYRMPVG 932
Score = 93.9 bits (223), Expect = 4e-18
Identities = 91/329 (27%), Positives = 146/329 (44%), Gaps = 23/329 (6%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIFK 142
V + + DVNDN P F + PY V + E TP G IF++ P L +V
Sbjct: 118 VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTP--IFIVNATDPDLGAGGSVLYSFQPPS 175
Query: 143 DIRAFDRDKPN-TPNSDVHYSIVSGNDDGHFALESSH-KPVLLLRK--VLDYDAGDKEFQ 198
A D + T ++ Y A + +P+ L ++ D D +
Sbjct: 176 QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPI 235
Query: 199 LVIMASGKRIHKEI---LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFL 255
+ + I++ I AIDQD G + Y ++SGN +F+LD ++G L L
Sbjct: 236 FINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTL 295
Query: 256 EKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV----EIELLDLNDNLPEFEVDFY 311
LD E+ L ++ F+L V+ ++LN+ + A V I ++D+NDN PEF Y
Sbjct: 296 NGL--LDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEY 353
Query: 312 NISIVENLPNGFSV---LQVMATDKDQGENGEF-TYQLDDPKGAFSIDPRS----GWLTV 363
+++I E GF++ +QV+ D++ G N F Y + + F I P S + +
Sbjct: 354 SVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRI 413
Query: 364 RNQTVLDREAHSSLRMKVYAKETNPSVVG 392
R LD E ++A E+ P VG
Sbjct: 414 RVAIPLDYETVDRYDFDLFANESVPDHVG 442
Score = 87.4 bits (207), Expect = 3e-16
Identities = 93/351 (26%), Positives = 154/351 (43%), Gaps = 24/351 (6%)
Query: 85 VYIEDVNDNVPIFLDTP--YHVTVDELTPTGEKAFIFLIAP---IGPSLTIPLTVPRG-- 137
V I D+NDN P+ +++P Y+V+V+E G A + + A IG + + + G
Sbjct: 1515 VTILDINDNPPV-IESPFGYNVSVNE-NVGGGTAVVQVRATDRDIGINSVLSYYITEGNK 1572
Query: 138 -LTIFKD-IRAFDRDKPNTPNSD---VHYSIVSGNDDGHFALESS-HKPVLLLRKVLDYD 191
+T D I +P P+ + ++ + + D+G L ++ H V ++ + +
Sbjct: 1573 DMTFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAP 1632
Query: 192 AGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
+ V++ G L I A+D D G T+ Y +++GN F +D G
Sbjct: 1633 MFQQPHYEVLLDEGPDTLNTSLIT--IQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMG 1690
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
+ KELD + H Q L++ L T+ V + + D+NDN+P F D+
Sbjct: 1691 VITAAKELDYEISHGRYTLIVTATDQCPILSHRL-TSTTTVLVNVNDINDNVPTFPRDYE 1749
Query: 312 N-ISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTV 368
+ E P G V +A D+D G NG+ Y + DP G F I P G L VR
Sbjct: 1750 GPFEVTEGQP-GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVE 1808
Query: 369 LDREAHSSLRMKVYAKETN-PSVVGTFADSQRIAKWR-RQPLETNAPLEKT 417
LDRE + + + A++ P + T R+ P+ N P+ T
Sbjct: 1809 LDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNIT 1859
Score = 87.0 bits (206), Expect = 5e-16
Identities = 134/517 (25%), Positives = 211/517 (40%), Gaps = 72/517 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPE+ P+G + + A D D+G NGQ+ V+ S A A E+ N+ G
Sbjct: 1428 IPEDCPVGQRVATVKAWDPDAGSNGQV-------VFSLASGNIAGAFEI---VTTNDSIG 1477
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFKKTW-YNFN 1053
V VAR L E + L + A D G D+I ++V + D+ND+ PV + + YN +
Sbjct: 1478 EVFVARPLDREELDHYILQVVASDRGTPPRKKDHI-LQVTILDINDNPPVIESPFGYNVS 1536
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVN-GELDRET 1112
V E + +V ATD D G N+ L+Y+I + D+ F + ++G ++ DRE
Sbjct: 1537 VNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMTFRMDRISGEIATRPAPPDRER 1596
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYA--FDELLEWKHPEADELSN 1170
+ Y L D G D NDN+P F ++ LL+ + P+ S
Sbjct: 1597 QSFYHLVATVEDEG-TPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLD-EGPDTLNTSL 1654
Query: 1171 HNFESVMMIPVYKATIEENAPIGTTV----------AKVFANDTDF-IGNGNGLILYSLP 1219
+++ + T+ G V A + D+ I +G ++ +
Sbjct: 1655 ITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVT-- 1712
Query: 1220 QRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSL 1279
+Q + L+ST ++V V D+ D V P F R YE E P V
Sbjct: 1713 -ATDQCPILSHRLTSTTTVLVNVNDINDNV-----PTF-PRDYEGPFEVTEGQPGPRVWT 1765
Query: 1280 NLTEHYE---NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSP--DREVKDTYEVIVR 1334
L + N ++ Y I+ D D FVI P G L + + DRE Y + +
Sbjct: 1766 FLAHDRDSGPNGQVEYSIM---DGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTIC 1822
Query: 1335 AERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTT 1394
A R +P P++ +L G +R+ D+NDN P N P+ I
Sbjct: 1823 AR----DRGMP----PLSSTMLVG---------IRVLDINDNDPVLL--NLPMNITISEN 1863
Query: 1395 AP---FGYQVMQLKGAIGHHPTASRTVRADTDELVFF 1428
+P F V+ G + + + A E FF
Sbjct: 1864 SPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFF 1900
Score = 81.4 bits (192), Expect = 2e-14
Identities = 113/492 (22%), Positives = 204/492 (41%), Gaps = 54/492 (10%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + +LD ND P F + S+ N GT + + A D D G NG + Y L+
Sbjct: 2493 VQVVIQVLDVNDCRPQFSKPQ-FSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGP 2551
Query: 503 SNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F ++ ++G V+ + +L V A+D P L V I+V
Sbjct: 2552 G----VEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVN-- 2605
Query: 563 TKGNKPDIPDFMGAPYE--FWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLH--GYEE 616
N+P F+ P + + + ++V ++ D E V Y L G +
Sbjct: 2606 --DNRPV---FVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRD 2660
Query: 617 GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV--DVNDERG 674
F ++ SG+I L R ++ +Y VA + T + V D++D
Sbjct: 2661 WEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEP 2720
Query: 675 VLL---KGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
+ + KG+ + V E+S G +G + + + G F+ A ++ +
Sbjct: 2721 LFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGA-VDADEGPNAIVYYFIAAGNEE--KNF 2777
Query: 731 AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKG------------VISGAGIYQVTIYIE 778
+ DG + + LDRE+ ++ V A N+ +++ + +V + +E
Sbjct: 2778 HLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLE 2837
Query: 779 DENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG--EGKEM 836
D ND PP F A Y + ++K+G+E+ + A DAD G N+L Y++ + +
Sbjct: 2838 DINDQPPRFTKAEYTAGVATDAKVGSELIQ---VLALDADIGNNSLVFYSILAIHYFRAL 2894
Query: 837 FDVDENTGVVKFIG--DSLDREKKIM-------YKLSLVARDTGGLSSEAEL-IIMIGDE 886
+ E+ G V +G D + R + + + +VARD G + A + I ++ D+
Sbjct: 2895 ANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDD 2954
Query: 887 NDNKPEFNQIEE 898
K N+I +
Sbjct: 2955 QRVKIVINEIPD 2966
Score = 80.6 bits (190), Expect = 4e-14
Identities = 47/148 (31%), Positives = 78/148 (52%), Gaps = 4/148 (2%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G A + Y L G + F+++ G +++ LD + + +
Sbjct: 2424 VTATDADSGNFALIEYSLGDGESK--FAINPTTGDIYVLSSLDREKKDHYILTALAKDNP 2481
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
+N + + +V I++LD+ND P+F ++ S+ EN P G SV+ +MATD+D+G
Sbjct: 2482 GDVASNRRENS-VQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGP 2540
Query: 338 NGEFTYQLDDP-KGAFSIDPRSGWLTVR 364
NGE TY L+ P AF +D SG +T +
Sbjct: 2541 NGELTYSLEGPGVEAFHVDMDSGLVTTQ 2568
Score = 80.2 bits (189), Expect = 5e-14
Identities = 128/492 (26%), Positives = 206/492 (41%), Gaps = 65/492 (13%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
E++P+GT I+ + A D DSG I Y E K F IN G +
Sbjct: 2413 EDVPVGTIILTVTATDADSGNFALIEYSLGDG-------------ESK--FAINPTTGDI 2457
Query: 1002 IVARSLPPESEFRLNISALDGGNLND--------NISVRVFVKDVNDHFPVFKKTWYNFN 1053
V SL E + ++AL N D ++ V + V DVND P F K ++ +
Sbjct: 2458 YVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTS 2517
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETE 1113
V E + + + ATD D G N LTY ++ + F + +G+++ L ++
Sbjct: 2518 VYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA-FHVDMDSGLVTTQRPL--QSY 2574
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNF 1173
+K+ LTVVA D G DVNDN P F E L ++ +
Sbjct: 2575 EKFSLTVVATDGGEPPLWGTTMLLVEVI-DVNDNRPVFVRPPNGTILHIREEIPLRSNVY 2633
Query: 1174 ESVMMIPVYKATIEE--NAPIGTTVAKVFAN-DTDF--IGNGNGLILYSLPQRKNQQ--- 1225
E VY +E N + + K N D +F I +GLI + + Q
Sbjct: 2634 E------VYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY 2687
Query: 1226 -------NLGLPSLSSTAI-LMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELV 1277
+LG P T L V + D+ D + +P S Y+L + ++P +
Sbjct: 2688 SLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQL-LTVPEHSPRGTL 2746
Query: 1278 SLNLT-----EHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVI 1332
N+T + N + Y+I N+ + F + P +G L ++R DRE + + I
Sbjct: 2747 VGNVTGAVDADEGPNAIVYYFIAAGNE---EKNFHLQP-DGCLLVLRDLDREREAIFSFI 2802
Query: 1333 VRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIP 1392
V+A + S P P D++ +T +V+VV ++D+ND P+FT +
Sbjct: 2803 VKASSNR-SWTPPRGPSPTL-DLVADLTLQEVRVV--LEDINDQPPRFTKAE--YTAGVA 2856
Query: 1393 TTAPFGYQVMQL 1404
T A G +++Q+
Sbjct: 2857 TDAKVGSELIQV 2868
Score = 78.2 bits (184), Expect = 2e-13
Identities = 56/175 (32%), Positives = 88/175 (50%), Gaps = 12/175 (6%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
+ G ++ ++PLDRE + + + ++GVI+ +V I + D NDN P F + Y
Sbjct: 83 DTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITR----KVNIQVGDVNDNAPTFHNQPYS 138
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
I EN+ +GT I I+ ATD D G +Y+ F + F +D G+V I + L
Sbjct: 139 VRIPENTPVGTPI---FIVNATDPDLGAGGSVLYS-FQPPSQFFAIDSARGIVTVIRE-L 193
Query: 854 DREKKIMYKLSLVARD---TGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIH 905
D E Y+L++ A D T LS+ A L I+I D D P F + ++ + H
Sbjct: 194 DYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEH 248
Score = 77.8 bits (183), Expect = 3e-13
Identities = 54/177 (30%), Positives = 86/177 (48%), Gaps = 9/177 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSL-DSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A+D D G+ + Y L+ L DS G + + +D + H L V
Sbjct: 2318 VAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLN-----FTV 2372
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+AS +P + A+ V +E++D+NDN P F+ Y ++ E++P G +L V ATD D G
Sbjct: 2373 RASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSG 2432
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
Y L D + F+I+P +G + V + LDRE + AK+ NP V +
Sbjct: 2433 NFALIEYSLGDGESKFAINPTTGDIYVLSS--LDREKKDHYILTALAKD-NPGDVAS 2486
Score = 76.6 bits (180), Expect = 6e-13
Identities = 53/164 (32%), Positives = 83/164 (50%), Gaps = 12/164 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTFVL 274
+ A D D G + + L SGN F + + N G +F+ + LD + + + ++L
Sbjct: 1441 VKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDRE-----ELDHYIL 1495
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDK 333
QV AS P + +++ +LD+NDN P E F YN+S+ EN+ G +V+QV ATD+
Sbjct: 1496 QVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDR 1555
Query: 334 DQGENGEFTYQLDDPKG--AFSIDPRSGWLTVRNQTVLDREAHS 375
D G N +Y + + F +D SG + R DRE S
Sbjct: 1556 DIGINSVLSYYITEGNKDMTFRMDRISGEIATR-PAPPDRERQS 1598
Score = 74.5 bits (175), Expect = 3e-12
Identities = 84/328 (25%), Positives = 137/328 (41%), Gaps = 25/328 (7%)
Query: 77 ISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIF--LIAPIGPSLTIPLTV 134
+S ++ + I DV D PIF++ PY + E +P G I + G I T+
Sbjct: 216 LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI 275
Query: 135 PRGLTIFKDIRAFDR-----------DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLL 183
G T I A D D+ N S V G + S
Sbjct: 276 VSGNT--NSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTT 333
Query: 184 LR-KVLDYDAGDKEFQLVIMASGKRIHKEILFPEP--IHAIDQDLGVGATLRYEL-ISGN 239
V+D + EF + ++ F P I +D+D +G +E+ + GN
Sbjct: 334 FNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGN 393
Query: 240 DRKLFSLD--SVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELL 297
+ F + SV G + + + ++ + + + A++ + P A+V+I L+
Sbjct: 394 NSHHFIISPTSVQGKADIRIRVAIPLDYET-VDRYDFDLFANE-SVPDHVGYAKVKITLI 451
Query: 298 DLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPR 357
+ NDN P F YNIS+ EN+ G SVL V+ATD D G GE +Y D FS+D
Sbjct: 452 NENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKD 511
Query: 358 SGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+G + + + LD E + + A++
Sbjct: 512 TGLIMLIAR--LDYELIQRFTLTIIARD 537
Score = 73.7 bits (173), Expect = 5e-12
Identities = 87/331 (26%), Positives = 138/331 (41%), Gaps = 22/331 (6%)
Query: 73 GLNQISAYLSVTVYIE--DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLT- 129
G + A S TV++ D+NDN P F + P+ V E P G + + + L
Sbjct: 864 GRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNG 923
Query: 130 -----IPLTVPRGLTIFKDIRAFDRDKPNTPNSDV-HYSIVSGNDDGHFALESSHKPVLL 183
+P+ +PR + + Y + D +SS + +
Sbjct: 924 LVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTI 983
Query: 184 LRKVLDY-DAGDKEFQLVIMAS-GKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDR 241
VLD D F V S + + +E ++ D D+G+ A L Y + GN
Sbjct: 984 --HVLDVNDETPTFFPAVYNVSVSEDVPREFRVVW-LNCTDNDVGLNAELSYFITGGNVD 1040
Query: 242 KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLND 301
FS+ + + + LD E A +L+ + T A V + +LD+ND
Sbjct: 1041 GKFSVGYRDA--VVRTVVGLDRE-TTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVND 1097
Query: 302 NLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSG 359
N P F Y S+ E++P G S+LQ+ ATD D+GE G Y++ + F I +G
Sbjct: 1098 NRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNG 1157
Query: 360 WLTVRNQTVLDREAHSS--LRMKVYAKETNP 388
L +R LDRE +SS L ++ Y + P
Sbjct: 1158 -LLMRGPRPLDRERNSSHVLIVEAYNHDLGP 1187
Score = 73.3 bits (172), Expect = 6e-12
Identities = 84/322 (26%), Positives = 134/322 (41%), Gaps = 36/322 (11%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTD 1090
V++ + + ND+ P+F + YN ++ E + V ATD D G ++YF SD
Sbjct: 446 VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF--SDDP 503
Query: 1091 LPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
F + TG++ + LD E ++ LT++ARD G DVNDN P
Sbjct: 504 DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG---GEETTGRVRINVLDVNDNVPT 560
Query: 1151 FY--AFDELLEWKHPEADEL------------SNHNFESVMMIPVYKATIEENAPIGTTV 1196
F A+ L P +L +N S++ + + + + G V
Sbjct: 561 FQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGV 620
Query: 1197 AKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPV 1256
V + D+ NGLI ++ + G P L+ST + + V D E + P
Sbjct: 621 ISV-SRPLDYEQISNGLIYLTV----MAMDAGNPPLNSTVPVTIEVFD-----ENDNPPT 670
Query: 1257 FISRYYELEIEENVNAPVELVSLNLT--EHYENFKMRYYILN-ENDTDIRRTFVIDPRNG 1313
F Y + + EN+ A ++ LN T + + I + E T R I+ R+G
Sbjct: 671 FSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFR----INARSG 726
Query: 1314 TLYLVRSPDREVKDTYEVIVRA 1335
+ DRE K Y +IVRA
Sbjct: 727 EITTTSLLDRETKSEYILIVRA 748
Score = 70.9 bits (166), Expect = 3e-11
Identities = 121/490 (24%), Positives = 194/490 (39%), Gaps = 62/490 (12%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN+ GT ++++ A D D G+N + Y YI F ++ G
Sbjct: 1537 VNENVGGGTAVVQVRATDRDIGINSVLSY------YITEGNKDMT-------FRMDRISG 1583
Query: 1000 HVIVARSLPPESE----FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFN 1053
I R PP+ E + L + D G L+ V V + D ND+ P+F++ Y
Sbjct: 1584 E-IATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVL 1642
Query: 1054 VEEAQYTRRV-LGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRE- 1111
++E T L + A D D G N +TY I + F I GV++ ELD E
Sbjct: 1643 LDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEI 1702
Query: 1112 TEDKYILTVVARDNG--XXXXXXXXXXXXXXXXDVNDNSPKF---YA--FDELLEWKHPE 1164
+ +Y L V A D D+NDN P F Y F+ P
Sbjct: 1703 SHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPR 1762
Query: 1165 ADELSNHNFESVMMIPVYKATIEENAPIG----TTVAKVFANDTDFIGNGNGLILYSLPQ 1220
H+ +S V + +I + P+G + V V D + + Y+L
Sbjct: 1763 VWTFLAHDRDSGPNGQV-EYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTI 1821
Query: 1221 RKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVS 1278
+ G+P LSST ++ + V D+ D + PV ++ + I EN V++ V V
Sbjct: 1822 CARDR--GMPPLSSTMLVGIRVLDIND-----NDPVLLNLPMNITISENSPVSSFVAHVL 1874
Query: 1279 LNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
+ + N ++ + I N R F I+ G + + R DRE Y++ +
Sbjct: 1875 ASDADSGCNARLTFNITAGNR---ERAFFINATTGIVTVNRPLDRERIPEYKLTISV--- 1928
Query: 1339 KYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFG 1398
K + E P + YD+ +++ + D NDN P FT + +P G
Sbjct: 1929 KDNPENPRI----------ARRDYDL-LLIFLSDENDNHPLFTKST--YQAEVMENSPAG 1975
Query: 1399 YQVMQLKGAI 1408
+ L G I
Sbjct: 1976 TPLTVLNGPI 1985
Score = 70.9 bits (166), Expect = 3e-11
Identities = 88/331 (26%), Positives = 134/331 (40%), Gaps = 23/331 (6%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIA---PIGPSLT 129
G +SA V V I D NDN P+F Y V +DE T + I + A GP+ T
Sbjct: 1610 GTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGT 1669
Query: 130 IPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR---- 185
+ + G I R T ++ Y I G + P+L R
Sbjct: 1670 VTYAIVAG-NIVNTFRIDRHMGVITAAKELDYEISHGRYT-LIVTATDQCPILSHRLTST 1727
Query: 186 KVLDYDAGDKEFQLVIMASGKRIHKEILFPEP------IHAIDQDLGVGATLRYELISGN 239
+ + D + E+ +P A D+D G + Y ++ G+
Sbjct: 1728 TTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGD 1787
Query: 240 DRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
F + V G L + K+++LD E N L + A P ++ V I +LD+
Sbjct: 1788 PLGEFVISPVEGVLRVRKDVELDRETIAFYN---LTICARDRGMPPLSSTMLVGIRVLDI 1844
Query: 300 NDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPR 357
NDN P NI+I EN P V V+A+D D G N T+ + + + AF I+
Sbjct: 1845 NDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINAT 1904
Query: 358 SGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
+G +TV LDRE ++ + K+ NP
Sbjct: 1905 TGIVTVNRP--LDRERIPEYKLTISVKD-NP 1932
Score = 69.7 bits (163), Expect = 7e-11
Identities = 61/215 (28%), Positives = 86/215 (40%), Gaps = 21/215 (9%)
Query: 939 LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERH 998
LI E+ P+G+++ +L A D+D+ P E R+F +
Sbjct: 41 LISEDTPVGSSVTQLLAQDMDND----------------PLVFGVSGEEASRFFAVEPDT 84
Query: 999 GHVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
G V + + L E SEF + S D + V + V DVND+ P F Y+ + E
Sbjct: 85 GVVWLRQPLDRETKSEFTVEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPYSVRIPE 143
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKY 1116
+ V+ATD D G ++ Y QP F I G+++V ELD ET Y
Sbjct: 144 NTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF--FAIDSARGIVTVIRELDYETTQAY 201
Query: 1117 ILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
LTV A D DV D P F
Sbjct: 202 QLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIF 236
Score = 68.9 bits (161), Expect = 1e-10
Identities = 87/327 (26%), Positives = 137/327 (41%), Gaps = 27/327 (8%)
Query: 582 VGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRP 641
+ + +G+SV Q+ D ND + G E FAVE +GV+ + L R +
Sbjct: 42 ISEDTPVGSSVTQLLAQDM--DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKS 99
Query: 642 MYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIF 701
+ E ++ ++ + I + V DVND + P + EN+ IF
Sbjct: 100 EFTVE-FSVSDHQGV-ITRKVNIQVGDVNDNAPTF---HNQPYSVRIPENTPVGT--PIF 152
Query: 702 HTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEF 760
N + G+V + Q + AI + G + + LD E Y++TV A
Sbjct: 153 IVNATDPDLGAGGSVLYSF---QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATD 209
Query: 761 NKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEG 820
+ + + I I D D P+F + Y I E+S GT ++ II A D D+G
Sbjct: 210 QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR---IITAIDQDKG 266
Query: 821 TNALFMYTLF-GEGKEMFDVDENTGVVKFIGDSLDREKKIM-YKLSLVARDT----GGLS 874
YT+ G +F +D +GV+ G LDRE + + L + T
Sbjct: 267 RPRGIGYTIVSGNTNSIFALDYISGVLTLNG-LLDRENPLYSHGFILTVKGTELNDDRTP 325
Query: 875 SEAELI----IMIGDENDNKPEFNQIE 897
S+A + I++ D NDN PEFN E
Sbjct: 326 SDATVTTTFNILVIDINDNAPEFNSSE 352
Score = 67.3 bits (157), Expect = 4e-10
Identities = 54/173 (31%), Positives = 80/173 (46%), Gaps = 8/173 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G + Y ++ GN F + NG L + LD E N ++ VL V+
Sbjct: 1124 LKATDADEGEFGRVWYRILHGNHGNNFRIHVSNG-LLMRGPRPLDRERN---SSHVLIVE 1179
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN-ISIVENLPNGFSVLQVMATDKDQG 336
A + + RV + + D+ND P F Y+ + + E G SV+ V ATD+D G
Sbjct: 1180 AYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSG 1239
Query: 337 ENGEFTYQ-LDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
+ G Y+ L +G F ID +G + N LD E +S M V A + P
Sbjct: 1240 DGGLVNYRILSGAEGKFEIDESTGLIITVN--YLDYETKTSYMMNVSATDQAP 1290
Score = 63.7 bits (148), Expect = 5e-09
Identities = 59/211 (27%), Positives = 92/211 (43%), Gaps = 31/211 (14%)
Query: 929 LDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEF-------NSEV 974
LDV+ P+FL +PE+IP G +I++L A D D G G++ Y N +
Sbjct: 1093 LDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRI 1152
Query: 975 YIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVF 1034
++ L + R HV++ + D G + ++ V V+
Sbjct: 1153 HVSNGLLMRGPRPLDR----ERNSSHVLIVEAYNH-----------DLGPMRSSVRVIVY 1197
Query: 1035 VKDVNDHFPVFKKTWYN-FNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPF 1093
V+D+ND PVF + Y+ + E + V ATD D G + Y I S + F
Sbjct: 1198 VEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRIL-SGAEGKF 1256
Query: 1094 EISPLTGVLSVNGELDRETEDKYILTVVARD 1124
EI TG++ LD ET+ Y++ V A D
Sbjct: 1257 EIDESTGLIITVNYLDYETKTSYMMNVSATD 1287
Score = 62.9 bits (146), Expect = 9e-09
Identities = 53/170 (31%), Positives = 77/170 (45%), Gaps = 8/170 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGND-RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D+D + Y ++S + F + G + LD E + L V
Sbjct: 583 LRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ-ISNGLIYLTV 641
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A NP + V IE+ D NDN P F Y +S+VEN+ G +VL + ATD D+
Sbjct: 642 MAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRS 701
Query: 337 -ENGE--FTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
E G+ Y L+ F I+ RSG +T ++LDRE S + V A
Sbjct: 702 REYGQESIIYSLEG-STQFRINARSGEIT--TTSLLDRETKSEYILIVRA 748
Score = 62.5 bits (145), Expect = 1e-08
Identities = 57/225 (25%), Positives = 96/225 (42%), Gaps = 15/225 (6%)
Query: 236 ISGNDR-KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
+SG + + F+++ G ++L + LD + + + F ++ S + +V I
Sbjct: 69 VSGEEASRFFAVEPDTGVVWLRQPLDRETK-----SEFTVEFSVSDHQGVITR---KVNI 120
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
++ D+NDN P F Y++ I EN P G + V ATD D G G Y P F+I
Sbjct: 121 QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180
Query: 355 DPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPS-VVGTFADSQRIAK--WRRQPLETN 411
D G +TV + LD E + ++ V A + + + + T A+ I P+ N
Sbjct: 181 DSARGIVTVIRE--LDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFIN 238
Query: 412 APLEKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNN 456
P Y GT I D+ + T++ N N+
Sbjct: 239 LPYSTNIYEH-SPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNS 282
Score = 61.7 bits (143), Expect = 2e-08
Identities = 59/203 (29%), Positives = 92/203 (45%), Gaps = 23/203 (11%)
Query: 935 GPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVI 994
G + I E IP+ + + ++ A D D GLNG +RY F L +F+I
Sbjct: 2617 GTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSF----------LKTAGNRDWEFFII 2666
Query: 995 NERHGHVIVARSLPPESE--FRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFKK-- 1047
+ G + A+ L ES+ + L + A D G ++V ++D++D+ P+F +
Sbjct: 2667 DPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPP 2726
Query: 1048 ----TWYNFNVEEAQYTRRVLGKV-DATDADFGQNANLTYFIQPSDTDLPFEISPLTGVL 1102
+ V E ++G V A DAD G NA + YFI + + F + P G L
Sbjct: 2727 KGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCL 2785
Query: 1103 SVNGELDRETEDKYILTVVARDN 1125
V +LDRE E + V A N
Sbjct: 2786 LVLRDLDREREAIFSFIVKASSN 2808
Score = 60.5 bits (140), Expect = 5e-08
Identities = 36/141 (25%), Positives = 67/141 (47%), Gaps = 5/141 (3%)
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
N F+++ GS+ ++ ++ + + V+ + + A++ + +LD
Sbjct: 2226 NQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLD 2285
Query: 299 LNDNLPEFE---VDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD--PKGAFS 353
+NDN P+F+ + +Y I+E G +++ V A D D+G NG TY L D P G
Sbjct: 2286 VNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQ 2345
Query: 354 IDPRSGWLTVRNQTVLDREAH 374
++ S + N+TV E H
Sbjct: 2346 LEDSSAGKVIANRTVDYEEVH 2366
Score = 58.4 bits (135), Expect = 2e-07
Identities = 41/126 (32%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D G + Y DR FSLD G + L LD + F L + A
Sbjct: 484 ATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYEL-----IQRFTLTIIAR 536
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
T RV I +LD+NDN+P F+ D Y ++ EN P+ ++++ ATD+D N
Sbjct: 537 DGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNN 594
Query: 340 EFTYQL 345
+ TY +
Sbjct: 595 QITYSI 600
Score = 58.4 bits (135), Expect = 2e-07
Identities = 114/498 (22%), Positives = 199/498 (39%), Gaps = 50/498 (10%)
Query: 83 VTVYIE--DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI--APIGPSLTIPLTVPRGL 138
+ VY+E D+NDN PIF Y V E P G A G I ++ G
Sbjct: 2386 IPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGE 2445
Query: 139 TIFK------DI---RAFDRDKPNTPNSDVHYSI--VSGNDDGHFALESSHKPVLLLRKV 187
+ F DI + DR+K + HY + ++ ++ G A V ++ +V
Sbjct: 2446 SKFAINPTTGDIYVLSSLDREKKD------HYILTALAKDNPGDVASNRRENSVQVVIQV 2499
Query: 188 LDYDAGDKEFQLVIMASGKRIHKEI-LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSL 246
LD + +F ++ ++ + A DQD G L Y L G + F +
Sbjct: 2500 LDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHV 2558
Query: 247 DSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF 306
D +G + ++ L F L V A+ P + +E++D+NDN P F
Sbjct: 2559 DMDSGLVTTQRPLQ-------SYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVF 2611
Query: 307 --EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKG-----AFSIDPRSG 359
+ + I E +P +V +V ATDKD+G NG Y G F IDP SG
Sbjct: 2612 VRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISG 2671
Query: 360 WLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGTFADSQRIAKWRRQPLETNAPLEKTTY 419
+ + LDRE+ + + + A + V ++A + ++ N PL +
Sbjct: 2672 LIQTAQR--LDRESQAVYSLILVASDLGQPVPYETMQPLQVA---LEDIDDNEPL----F 2722
Query: 420 VFPDKVGTKTENIEYYDEQLMSFVNVEVT-LLDANDNNPVFVPSNLYEFSMKSNAKVGTV 478
V P K + + + + + VT +DA++ V + + + N +
Sbjct: 2723 VRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD 2782
Query: 479 IGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEA 538
+ D D + + + ++ +SN + T P +P T+ + L+ + +
Sbjct: 2783 GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSP---TLDLVADLTLQEVRVVLEDI 2839
Query: 539 SDQPANPSERRYSLAVVT 556
+DQP ++ Y+ V T
Sbjct: 2840 NDQPPRFTKAEYTAGVAT 2857
Score = 50.8 bits (116), Expect = 4e-05
Identities = 39/129 (30%), Positives = 63/129 (48%), Gaps = 10/129 (7%)
Query: 230 TLRYELISGNDRK-LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTA 288
T R++ + K LF +D++ G + ++ +D + + + + L V A P +
Sbjct: 1347 TYRFDAYTSTQAKALFKIDAITGVITVQGLVDRE-----KGDFYTLTVVADD-GGPKVDS 1400
Query: 289 QARVEIELLDLNDNLPEFEVDFYN-ISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-- 345
+V I +LD NDN P F+ + +SI E+ P G V V A D D G NG+ + L
Sbjct: 1401 TVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLAS 1460
Query: 346 DDPKGAFSI 354
+ GAF I
Sbjct: 1461 GNIAGAFEI 1469
Score = 49.2 bits (112), Expect = 1e-04
Identities = 79/323 (24%), Positives = 135/323 (41%), Gaps = 34/323 (10%)
Query: 81 LSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIA--PIGPS--LTIPLTVP- 135
+ V + + DVND P F + +V E P G + GP+ LT L P
Sbjct: 2493 VQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPG 2552
Query: 136 -RGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
+ D +P ++V+ D G L + +LL +V+D +
Sbjct: 2553 VEAFHVDMDSGLVTTQRPLQSYEKFSLTVVA-TDGGEPPLWGT---TMLLVEVIDVNDNR 2608
Query: 195 KEFQLVIMASGKRIHKEILFPE---PIHAIDQDLGVGATLRYELI--SGN-DRKLFSLDS 248
F + I +EI ++A D+D G+ +RY + +GN D + F +D
Sbjct: 2609 PVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDP 2668
Query: 249 VNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPL--KTAQARVEIELLDLNDNLPEF 306
++G + + LD +++ + L + AS L P+ +T Q +++ L D++DN P F
Sbjct: 2669 ISGLIQTAQRLDRESQ-----AVYSLILVASDLGQPVPYETMQP-LQVALEDIDDNEPLF 2722
Query: 307 ------EVDFYNISIVENLPNGFSVLQVM-ATDKDQGENGEFTYQL--DDPKGAFSIDPR 357
+ +++ E+ P G V V A D D+G N Y + + + F + P
Sbjct: 2723 VRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP- 2781
Query: 358 SGWLTVRNQTVLDREAHSSLRMK 380
G L V +REA S +K
Sbjct: 2782 DGCLLVLRDLDREREAIFSFIVK 2804
Score = 45.2 bits (102), Expect = 0.002
Identities = 35/137 (25%), Positives = 61/137 (44%), Gaps = 15/137 (10%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G A + Y + +GN+ K F L +G L + ++LD + E +F+++ ++
Sbjct: 2753 AVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIF---SFIVKASSN 2808
Query: 280 QLNNPLKTAQA-----------RVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQV 328
+ P + V + L D+ND P F Y + + G ++QV
Sbjct: 2809 RSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQV 2868
Query: 329 MATDKDQGENGEFTYQL 345
+A D D G N Y +
Sbjct: 2869 LALDADIGNNSLVFYSI 2885
Score = 44.8 bits (101), Expect = 0.002
Identities = 44/152 (28%), Positives = 72/152 (47%), Gaps = 28/152 (18%)
Query: 1233 SSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN--FKM 1290
+ TA + VTV DV D ++P+F+ YE + E++ ++ L T+ E ++
Sbjct: 1083 TGTATVFVTVLDVND-----NRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRV 1137
Query: 1291 RYYILNENDTDIRRTFVIDPRNGTLYLVRSP-DREVKDTYEVIVRAERQKYSRELPHMIY 1349
Y IL+ N + F I NG L P DRE ++ +IV A Y+ +L
Sbjct: 1138 WYRILHGNHGN---NFRIHVSNGLLMRGPRPLDRERNSSHVLIVEA----YNHDL----- 1185
Query: 1350 PVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
G + V+V+V ++D+ND +P FT
Sbjct: 1186 --------GPMRSSVRVIVYVEDINDEAPVFT 1209
Score = 40.7 bits (91), Expect = 0.039
Identities = 40/151 (26%), Positives = 67/151 (44%), Gaps = 12/151 (7%)
Query: 79 AYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS----LTIPLTV 134
A S+ + D+ VP P V ++++ + +F+ P G LT+P
Sbjct: 2685 AVYSLILVASDLGQPVPYETMQPLQVALEDID---DNEPLFVRPPKGSPQYQLLTVPEHS 2741
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
PRG + A D D+ PN+ V+Y I +GN++ +F L+ LL+ + LD + +
Sbjct: 2742 PRGTLVGNVTGAVDADEG--PNAIVYYFIAAGNEEKNFHLQPD--GCLLVLRDLDRER-E 2796
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAIDQDL 225
F ++ AS R P P + DL
Sbjct: 2797 AIFSFIVKASSNRSWTPPRGPSPTLDLVADL 2827
Score = 37.5 bits (83), Expect = 0.37
Identities = 19/51 (37%), Positives = 27/51 (52%), Gaps = 4/51 (7%)
Query: 1441 ATDSDIGINADIRYQILNEQAPR----FAIDPVSGTVRVVAALARDAGRVF 1487
ATD D G+N +RY L R F IDP+SG ++ L R++ V+
Sbjct: 2637 ATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY 2687
Score = 35.1 bits (77), Expect = 2.0
Identities = 21/54 (38%), Positives = 27/54 (50%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI 1084
VRV ++D+ND P F K Y V L +V A DAD G N+ + Y I
Sbjct: 2832 VRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSI 2885
Score = 33.5 bits (73), Expect = 6.0
Identities = 16/45 (35%), Positives = 25/45 (55%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTP 111
+V AG S+ ++T+++ DVND P F Y+V+V E P
Sbjct: 965 VVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVP 1009
>AL772287-2|CAI13626.1| 3359|Homo sapiens cadherin-like 23 protein.
Length = 3359
Score = 161 bits (392), Expect = 1e-38
Identities = 140/469 (29%), Positives = 215/469 (45%), Gaps = 25/469 (5%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L + +V VT++D NDN P+F + + + T + ++A+D D G NG V Y
Sbjct: 1619 LSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYA 1678
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAES---PILEGRHALFVEASDQPANPSERRYSLAVV 555
+ + I + F+I+ + G ++ A+ I GR+ L V A+DQ S R S V
Sbjct: 1679 IVAGN---IVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTV 1735
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGS-NVGIGTSVGQIRVNDAFEQNDVSYDLLHGY 614
+ V N P P P+E G + T + R D+ V Y ++ G
Sbjct: 1736 LVNVN-DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDR--DSGPNGQVEYSIMDGD 1792
Query: 615 EEGVPFAVEERSGVITVVDD--LSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVND 671
G F + GV+ V D L R Y+ A LS + V+D+ND
Sbjct: 1793 PLG-EFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDIND 1851
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
VLL + P+ + ENS ++ + H S + F I
Sbjct: 1852 NDPVLL---NLPMNITISENSPVSSF--VAHVLASDADSGCNARLTFNITAGNRERAFFI 1906
Query: 732 IAEDGTIFTQKPLDREKRDVYRMTVIAEFN--KGVISGAGIYQVTIYIEDENDNPPVFEH 789
A G + +PLDRE+ Y++T+ + N I+ + I++ DENDN P+F
Sbjct: 1907 NATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTK 1966
Query: 790 ATYEGFIMENSKIGTEIKMDN-IIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+TY+ +MENS GT + + N I A DAD+ A+ Y L G +FD++ +TGVV
Sbjct: 1967 STYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTV 2026
Query: 849 -IGDSLDRE--KKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFN 894
G +DRE + +L L+A D G L+S A L+I I D+NDN+P F+
Sbjct: 2027 RSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFS 2075
Score = 156 bits (378), Expect = 7e-37
Identities = 254/1016 (25%), Positives = 428/1016 (42%), Gaps = 138/1016 (13%)
Query: 439 LMSFVNVEVTLLDANDNNPVFV--PSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
L S + V + +LD NDN+PV + P N+ ++ N+ V + + V A D D G N +
Sbjct: 1836 LSSTMLVGIRVLDINDNDPVLLNLPMNI---TISENSPVSSFVAHVLASDADSGCNARLT 1892
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR---HALFVEASDQPANP--SERRYS 551
+++ + F IN TG V+V P+ R + L + D P NP + R Y
Sbjct: 1893 FNITAGNR---ERAFFINATTGIVTV-NRPLDRERIPEYKLTISVKDNPENPRIARRDYD 1948
Query: 552 LAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSV----GQIRVNDAFEQ--ND 605
L ++ + + P F + Y+ V N GT + G I DA +
Sbjct: 1949 LLLIFLS------DENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV 2002
Query: 606 VSYDLLHGYEEGVPFAVEERSGVITV----VDDLSRYNRPMYDFEAVALQENANLSIVTN 661
V+Y LL G + G+ F + +GV+TV + D ++ P+ + +A ++ L+ +
Sbjct: 2003 VTYQLL-GAQSGL-FDINSSTGVVTVRSGVIIDREAFSPPILELLLLA-EDIGLLNSTAH 2059
Query: 662 ATVHVVDVNDERGVLLKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLI 720
+ ++D ND R + + + H+ EN G ++ Q+ T+ S G V +
Sbjct: 2060 LLITILDDNDNRPTF---SPATLTVHLLENCPPGFSVLQVTATDEDS--GLNGELVYRIE 2114
Query: 721 ANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDE 780
A QD I + +DRE+++ YR+TV+A ++G + +G VTI I+D
Sbjct: 2115 AGAQD-RFLIHLVTGVIRVGNATIDREEQESYRLTVVAT-DRGTVPLSGTAIVTILIDDI 2172
Query: 781 NDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVD 840
ND+ P F + ++E+++ GT I NI T D N Y + G + D
Sbjct: 2173 NDSRPEFLNPIQTVSVLESAEPGTVIA--NI---TAIDHDLNPKLEYHIVG----IVAKD 2223
Query: 841 ENTGVVKFIGDSLD---REKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIE 897
+ +V D+ +M K S + R+ L + E+ + + D + PE +
Sbjct: 2224 DTDRLVPNQEDAFAVNINTGSVMVK-SPMNRE---LVATYEVTLSVIDNASDLPERSVSV 2279
Query: 898 ENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALD 957
N+K+ ++ + T F KP F + + I E GTT+I + A+D
Sbjct: 2280 PNAKLTVNVLDVNDNTPQF-----KP---FGITYY----MERILEGATPGTTLIAVAAVD 2327
Query: 958 LDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLN- 1016
D GLNG + Y +PP + + + G VI R++ E LN
Sbjct: 2328 PDKGLNGLVTYTLLD--LVPPGYVQLE----------DSSAGKVIANRTVDYEEVHWLNF 2375
Query: 1017 -ISALDGGNLNDNISVRVFVK--DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD 1073
+ A D G+ + V+++ D+ND+ P+F + Y V E ++ V ATDAD
Sbjct: 2376 TVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDAD 2435
Query: 1074 FGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG---XXXX 1130
G A + Y + D + F I+P TG + V LDRE +D YILT +A+DN
Sbjct: 2436 SGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNR 2493
Query: 1131 XXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENA 1190
DVND P+F P+ N + + AT ++
Sbjct: 2494 RENSVQVVIQVLDVNDCRPQF---------SKPQFSTSVYENEPAGTSVITMMATDQDEG 2544
Query: 1191 PIGTTVAKVFANDTD--FIGNGNGLILYSLPQRKNQQ--------NLGLPSLSSTAILMV 1240
P G + + + +GL+ P + ++ + G P L T +L+V
Sbjct: 2545 PNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLV 2604
Query: 1241 TVADVPDEVEMSDKPVFI--SRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILN 1296
V DV D ++PVF+ L I E + + + T+ E N +RY L
Sbjct: 2605 EVIDVND-----NRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLK 2659
Query: 1297 ENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVL 1356
F+IDP +G + + DRE + Y +I+ A + PV + +
Sbjct: 2660 TAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS---------DLGQPVPYETM 2710
Query: 1357 EGMTKYDVKVVVRIKDVNDNSPKFT----NGNRPLVTAIPTTAPFGYQVMQLKGAI 1408
+ + V ++D++DN P F + + +P +P G V + GA+
Sbjct: 2711 QPLQ-------VALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAV 2759
Score = 150 bits (364), Expect = 3e-35
Identities = 256/1011 (25%), Positives = 406/1011 (40%), Gaps = 135/1011 (13%)
Query: 432 IEYYDEQL---MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPD 488
+E Y+ L S V V V + D ND PVF ++ A +GT + V+A D D
Sbjct: 1183 VEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRD 1242
Query: 489 LGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPS 546
G G+V Y + + F+I+ +TG + E + + + V A+DQ A P
Sbjct: 1243 SGDGGLVNYRILSGAE----GKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQ-APPF 1297
Query: 547 ERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDV 606
+ + +T+ + F A YE + N+ +GT + +++ N +
Sbjct: 1298 NQGFCSVYITL------LNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQI 1351
Query: 607 SY--DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
+Y + + F ++ +GVITV + R Y VA + +
Sbjct: 1352 TYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYI 1411
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGT-GNVRFLIANQ 723
V+D ND + S + + E+ +GQ T + G+ G V F +A+
Sbjct: 1412 TVLDENDNSPRFDFTSDSAV--SIPED---CPVGQRVATVKAWDPDAGSNGQVVFSLASG 1466
Query: 724 QDV-TDDIAIAED--GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDE 780
+I D G +F +PLDRE+ D Y + V+A ++G + + + I D
Sbjct: 1467 NIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVAS-DRGTPPRKKDHILQVTILDI 1525
Query: 781 NDNPPVFEHAT-YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM-FD 838
NDNPPV E Y + EN GT + ++ATD D G N++ Y + K+M F
Sbjct: 1526 NDNPPVIESPFGYNVSVNENVGGGTAVVQ---VRATDRDIGINSVLSYYITEGNKDMAFR 1582
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQI 896
+D +G + DRE++ Y L D G LS+ + + I DENDN P F Q
Sbjct: 1583 MDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQ- 1641
Query: 897 EENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNAL 956
+ +V + T+ TI ALD+D+ GP + I G + N
Sbjct: 1642 -PHYEVLLDEGPDTLNTSLITI--------QALDLDE-GPNGTVTYAIVAGNIV---NTF 1688
Query: 957 DLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLN 1016
+D + G I +A L+ Y + + R+ ++ A P RL
Sbjct: 1689 RIDRHM-GVI--------------TAAKELD---YEISHGRYTLIVTATDQCPILSHRLT 1730
Query: 1017 ISALDGGNLND-NISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFG 1075
+ N+ND N +V F +D F V E Q RV + A D D G
Sbjct: 1731 STTTVLVNVNDINDNVPTFPRDYEG----------PFEVTEGQPGPRVWTFL-AHDRDSG 1779
Query: 1076 QNANLTYFIQPSDTDLPFEISPLTGVLSV--NGELDRETEDKYILTVVARDNGXXXXXXX 1133
N + Y I D F ISP+ GVL V + ELDRET Y LT+ ARD G
Sbjct: 1780 PNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRG-MPPLSS 1838
Query: 1134 XXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIG 1193
D+NDN P ++ +P+ TI EN+P+
Sbjct: 1839 TMLVGIRVLDINDNDP-------------------------VLLNLPM-NITISENSPVS 1872
Query: 1194 TTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPD---EVE 1250
+ VA V A+D D N + R+ + + T + +P+ +
Sbjct: 1873 SFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTIS 1932
Query: 1251 MSDKPV---FISRYYELEI----EENVNAPVELVSLNLTEHYENFK--MRYYILN----- 1296
+ D P R Y+L + +EN N P+ S E EN +LN
Sbjct: 1933 VKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILA 1992
Query: 1297 -ENDTDIRR--TFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAE 1353
+ D DI T+ + L+ + S V VI+ +R+ +S + ++ +AE
Sbjct: 1993 LDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVII--DREAFSPPILELLL-LAE 2049
Query: 1354 DVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQL 1404
D+ G+ +++ I D NDN P F+ L + P G+ V+Q+
Sbjct: 2050 DI--GLLNSTAHLLITILDDNDNRPTFSPAT--LTVHLLENCPPGFSVLQV 2096
Score = 135 bits (327), Expect = 1e-30
Identities = 215/803 (26%), Positives = 315/803 (39%), Gaps = 128/803 (15%)
Query: 403 WRRQPLETNAPLEKTT-YVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVF-- 459
W RQPL+ E T + D G T VN++V D NDN P F
Sbjct: 88 WLRQPLDRETKSEFTVEFSVSDHQGVITRK-----------VNIQVG--DVNDNAPTFHN 134
Query: 460 --VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNT 517
+ E N VGT I V A DPDLG G VLY Q S F I+
Sbjct: 135 QPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF-----FAIDSAR 189
Query: 518 GTVSVAESPILEGRHA--LFVEASDQP-ANPSERRYSLAVVTIEVTRGTKGNKPDIPDFM 574
G V+V E A L V A+DQ P +LA++ +V + P F+
Sbjct: 190 GIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV-------QDMDPIFI 242
Query: 575 GAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLH--GYEEGVPFAVEERSGVIT 630
PY + + GT+V I D + Y ++ G + FA++ SGV+T
Sbjct: 243 NLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNTNSI-FALDYISGVLT 301
Query: 631 VVDDLSRYNRPMYDFEAVALQENANLS---------IVTNATVHVVDVNDERGVLLKGAH 681
+ L R N P+Y + + L+ + T + V+D+ND +
Sbjct: 302 LNGLLDREN-PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEY 360
Query: 682 SPIIFHVKENSAGAAIG-QIFH-----TNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED 735
S I + + + Q+ +M +Y G + F+I+ + D
Sbjct: 361 SVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSHHFIIS-----PTSVQGKAD 415
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
I PLD E D Y + A N+ V G +V I + +ENDN P+F Y
Sbjct: 416 IRIRVAIPLDYETVDRYDFDLFA--NESVPDHVGYAKVKITLINENDNRPIFSQPLYNIS 473
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
+ EN +GT + + ATD D GT FGE V F D DR
Sbjct: 474 LYENVTVGTSVLT---VLATDNDAGT--------FGE------------VSYFFSDDPDR 510
Query: 856 EKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAG 915
+ L +DTG LI++I + ++ I+ + I R+ T G
Sbjct: 511 -----FSLD---KDTG-------LIMLIA-----RLDYELIQRFTLTIIARDGGGEETTG 550
Query: 916 FTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVY 975
I V N + + + EN P T +++L A D DS N QI Y
Sbjct: 551 RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITY------- 603
Query: 976 IPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE------FRLNISALDGGN--LND 1027
S +SA A YF I+ G+ +++ S P + E L + A+D GN LN
Sbjct: 604 ---SIVSASAFG--SYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNS 658
Query: 1028 NISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
+ V + V D ND+ P F K Y +V E + ++ATD D + I
Sbjct: 659 TVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL 718
Query: 1088 DTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG-XXXXXXXXXXXXXXXXDVND 1146
+ F I+ +G ++ LDRET+ +YIL V A D G D+ND
Sbjct: 719 EGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIND 778
Query: 1147 NSPKFY---AFDELLEWKHPEAD 1166
N P + + L+E P++D
Sbjct: 779 NHPTWKDAPYYINLVEMTPPDSD 801
Score = 118 bits (285), Expect = 1e-25
Identities = 134/498 (26%), Positives = 206/498 (41%), Gaps = 48/498 (9%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
Q V +TLLD NDN+P + + Y ++ + + V AVDPDLG+NG ++Y
Sbjct: 762 QKTGIATVNITLLDINDNHPTWKDAPYY-INLVEMTPPDSDVTTVVAVDPDLGENGTLVY 820
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVA------ESP---ILEGRHALFVEASDQPANPSER 548
+Q + + +N TG + E+P E + V +D P +
Sbjct: 821 SIQPPNKF-----YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTD-CGRPPLK 874
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDV 606
S A V + + N D P F P+ V + G S+ Q+ D E V
Sbjct: 875 ATSSATVFVNL---LDLNDND-PTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLV 930
Query: 607 SYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVH 665
SY + G + F + SGV+ +L R Y VA S + T+H
Sbjct: 931 SYRMPVGMPR-MDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIH 989
Query: 666 VVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTG-NVR---FLIA 721
V+DVNDE P +++V S + + F + N G N F+
Sbjct: 990 VLDVNDETPTFF-----PAVYNV---SVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG 1041
Query: 722 NQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVIS--GAGIYQVTIYIED 779
D + D + T LDRE Y M ++ + G + G V + + D
Sbjct: 1042 GNVDGKFSVGY-RDAVVRTVVGLDRETTAAY-MLILEAIDNGPVGKRHTGTATVFVTVLD 1099
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMY-TLFGEGKEMFD 838
NDN P+F ++YE + E+ G I +KATDADEG Y L G F
Sbjct: 1100 VNDNRPIFLQSSYEASVPEDIPEGHSILQ---LKATDADEGEFGRVWYRILHGNHGNNFR 1156
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVA--RDTGGLSSEAELIIMIGDENDNKPEFNQI 896
+ + G++ LDRE+ + L + A D G + S +I+ + D ND P F Q
Sbjct: 1157 IHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQ- 1215
Query: 897 EENSKVRIHRETKLNGTA 914
++ S++ + RET GT+
Sbjct: 1216 QQYSRLGL-RETAGIGTS 1232
Score = 107 bits (257), Expect = 3e-22
Identities = 125/441 (28%), Positives = 195/441 (44%), Gaps = 37/441 (8%)
Query: 443 VNVEVTLLDANDNNPVF-VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQR 501
+ V + ++D NDNNP+F PS Y+ ++ + VGT+I V A D D G ++ Y L
Sbjct: 2391 IPVYLEIVDINDNNPIFDQPS--YQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGD 2448
Query: 502 TSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPAN-PSERRYSLAVVTIE 558
S F INP TG + V S E + + L A D P + S RR + V I+
Sbjct: 2449 GE-----SKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQ 2503
Query: 559 VTRGTKGNKPDI--PDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGY 614
V +P P F + YE N GTSV + D E +++Y L
Sbjct: 2504 VL-DVNDCRPQFSKPQFSTSVYE-----NEPAGTSVITMMATDQDEGPNGELTYSLEGPG 2557
Query: 615 EEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTNATVHVVDVNDER 673
E F V+ SG++T L Y + + VA L T V V+DVND R
Sbjct: 2558 VEA--FHVDMDSGLVTTQRPLQSYEK--FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNR 2613
Query: 674 GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFL-IANQQDVTDDIAI 732
V ++ + I+ +E + + +++ T+ NG FL A +D I
Sbjct: 2614 PVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGL-NGAVRYSFLKTAGNRDWEFFIID 2672
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH--- 789
G I T + LDRE + VY + ++A + + + + +ED +DN P+F
Sbjct: 2673 PISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPK 2732
Query: 790 --ATYEGF-IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVV 846
Y+ + E+S GT + N+ A DADEG NA+ Y + +E + G +
Sbjct: 2733 GSPQYQLLTVPEHSPRGTLV--GNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCL 2790
Query: 847 KFIGDSLDREKKIMYKLSLVA 867
+ D LDRE++ ++ + A
Sbjct: 2791 LVLRD-LDREREAIFSFIVKA 2810
Score = 105 bits (252), Expect = 1e-21
Identities = 122/457 (26%), Positives = 197/457 (43%), Gaps = 29/457 (6%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLT 506
+ +LD ND P F P+ +Y S+ + + + D D+G N + Y + +
Sbjct: 988 IHVLDVNDETPTFFPA-VYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFI---TGGN 1043
Query: 507 ITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIEVTRGTK 564
+ F + V E + L +EA D P +R++
Sbjct: 1044 VDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDN--GPVGKRHTGTATVFVTVLDVN 1101
Query: 565 GNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQN--DVSYDLLHGYEEGVPFAV 622
N+P F+ + YE V ++ G S+ Q++ DA E V Y +LHG G F +
Sbjct: 1102 DNRPI---FLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHG-NHGNNFRI 1157
Query: 623 EERSGVITVVD---DLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKG 679
+G++ D R + + EA S V V+V D+NDE V +
Sbjct: 1158 HVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSV-RVIVYVEDINDEAPVFTQQ 1216
Query: 680 AHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTI 738
+S + ++E + G ++ + T+ S G+G G V + I + + +I G I
Sbjct: 1217 QYSRL--GLRETAGIGTSVIVVQATDRDS--GDG-GLVNYRILSGAEGKFEID-ESTGLI 1270
Query: 739 FTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIME 798
T LD E + Y M V A ++ G V I + +E D F +A+YE I+E
Sbjct: 1271 ITVNYLDYETKTSYMMNVSAT-DQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILE 1329
Query: 799 NSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKK 858
N +GTEI + ++ T YT + K +F +D TGV+ G +DREK
Sbjct: 1330 NLALGTEIVRVQAYSIDNLNQITYRFNAYT-STQAKALFKIDAITGVITVQG-LVDREKG 1387
Query: 859 IMYKLSLVARDTG-GLSSEAELIIMIGDENDNKPEFN 894
Y L++VA D G + S ++ I + DENDN P F+
Sbjct: 1388 DFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFD 1424
Score = 105 bits (251), Expect = 2e-21
Identities = 118/439 (26%), Positives = 185/439 (42%), Gaps = 33/439 (7%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
S V V LLD NDN+P F NL + + G I +V A+D D G NG+V Y
Sbjct: 877 SSATVFVNLLDLNDNDPTF--QNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSY-- 932
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTI 557
R F IN ++G V E + L V ASD +L + +
Sbjct: 933 -RMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVL 991
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYE 615
+V T P F A Y V +V V + ND ++SY + G
Sbjct: 992 DVNDET-------PTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNV 1044
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQEN-ANLSIVTNATVHV--VDVNDE 672
+G F+V R V+ V L R Y A+ ATV V +DVND
Sbjct: 1045 DG-KFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDN 1103
Query: 673 RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI 732
R + L+ ++ + ++ G +I Q+ T+ G V + I + +
Sbjct: 1104 RPIFLQSSYEASV--PEDIPEGHSILQLKATDADE---GEFGRVWYRILHGNHGNNFRIH 1158
Query: 733 AEDGTIFT-QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
+G + +PLDRE+ + + ++ +N + +V +Y+ED ND PVF
Sbjct: 1159 VSNGLLMRGPRPLDRERNSSH-VLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQ 1217
Query: 792 YEGF-IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIG 850
Y + E + IGT + +++ATD D G L Y + + F++DE+TG++ +
Sbjct: 1218 YSRLGLRETAGIGTSVI---VVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITV- 1273
Query: 851 DSLDREKKIMYKLSLVARD 869
+ LD E K Y +++ A D
Sbjct: 1274 NYLDYETKTSYMMNVSATD 1292
Score = 104 bits (249), Expect = 3e-21
Identities = 91/334 (27%), Positives = 155/334 (46%), Gaps = 24/334 (7%)
Query: 71 GAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSL 128
G G NQ + +V + + D+NDN P + D PY++ + E+TP + + + P +G +
Sbjct: 757 GVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENG 816
Query: 129 TIPLTVPRGLTIFK------DIRA----FDRDKPNTPNSDVHYSIV-SGNDDGHFALESS 177
T+ ++ + IR DR+ P+ +++ IV S D G L+++
Sbjct: 817 TLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKAT 876
Query: 178 HKPVLLLRKVLDYDAGDKEFQ-LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELI 236
+ + +LD + D FQ L +A + + AID D G+ + Y +
Sbjct: 877 SSATVFVN-LLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP 935
Query: 237 SGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
G R F ++S +G + ELD + Q L+V AS P K++ + + I +
Sbjct: 936 VGMPRMDFLINSSSGVVVTTTELDRERIAEYQ-----LRVVASDAGTPTKSSTSTLTIHV 990
Query: 297 LDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSI 354
LD+ND P F YN+S+ E++P F V+ + TD D G N E +Y + + G FS+
Sbjct: 991 LDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSV 1050
Query: 355 DPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
R VR LDRE ++ + + A + P
Sbjct: 1051 GYRDA--VVRTVVGLDRETTAAYMLILEAIDNGP 1082
Score = 104 bits (249), Expect = 3e-21
Identities = 106/424 (25%), Positives = 180/424 (42%), Gaps = 22/424 (5%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI--APIGPSLTI 130
G+ +S+ + V + + D+NDN P+ L+ P ++T+ E +P L A G + +
Sbjct: 1832 GMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARL 1891
Query: 131 PLTVPRG-------LTIFKDIRAFDR--DKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
+ G + I +R D+ P + S+ ++ A +
Sbjct: 1892 TFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1951
Query: 182 LLLRKVLDYDA--GDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGN 239
+ L D +Q +M + + PI A+D D + A + Y+L+ G
Sbjct: 1952 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GA 2010
Query: 240 DRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
LF ++S G + + + +D E L + A + L + A + I +LD
Sbjct: 2011 QSGLFDINSSTGVVTVRSGVIIDREA-FSPPILELLLLAEDIG--LLNSTAHLLITILDD 2067
Query: 300 NDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD-DPKGAFSIDPRS 358
NDN P F + ++EN P GFSVLQV ATD+D G NGE Y+++ + F I +
Sbjct: 2068 NDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVT 2127
Query: 359 GWLTVRNQTVLDREAHSSLRMKVYAKETNP-SVVGTFADSQRIAKWRRQPLETNAPLEKT 417
G + V N T+ DRE S R+ V A + + GT + I E P++
Sbjct: 2128 GVIRVGNATI-DREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTV 2186
Query: 418 TYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGT 477
+ + + GT NI D L + + + A D+ VP+ F++ N G+
Sbjct: 2187 SVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAV--NINTGS 2244
Query: 478 VIGK 481
V+ K
Sbjct: 2245 VMVK 2248
Score = 101 bits (242), Expect = 2e-20
Identities = 135/518 (26%), Positives = 204/518 (39%), Gaps = 65/518 (12%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN T TI EV +N + + ENI G T++ LNA DLD Y
Sbjct: 656 LNSTVPVTI-EVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSR----EYG 710
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG---N 1024
S +Y +LE F IN R G + L E SE+ L + A+DGG N
Sbjct: 711 QESIIY---------SLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHN 761
Query: 1025 LNDNI-SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYF 1083
I +V + + D+ND+ P +K Y N+ E + V A D D G+N L Y
Sbjct: 762 QKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS 821
Query: 1084 IQPSDTDLPFEISPLTG-VLSVNGELDRETEDKY------ILTVVARDNGX-XXXXXXXX 1135
IQP + + ++ TG + + + LDRE D + + V D G
Sbjct: 822 IQPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 879
Query: 1136 XXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTT 1195
D+NDN P F + E +S + ++ + + P+G
Sbjct: 880 TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMP 939
Query: 1196 VAKVFANDTDFIG------NGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEV 1249
N + + + + Y L R + G P+ SST+ L + V DV DE
Sbjct: 940 RMDFLINSSSGVVVTTTELDRERIAEYQL--RVVASDAGTPTKSSTSTLTIHVLDVNDET 997
Query: 1250 EMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV 1307
P F Y + + E+V +V LN T++ N ++ Y+I N + F
Sbjct: 998 -----PTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGN---VDGKFS 1049
Query: 1308 IDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVV 1367
+ R+ + V DRE Y +I+ A PV + T V
Sbjct: 1050 VGYRDAVVRTVVGLDRETTAAYMLILEAIDNG----------PVGKRHTGTAT-----VF 1094
Query: 1368 VRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQLK 1405
V + DVNDN P F + ++P P G+ ++QLK
Sbjct: 1095 VTVLDVNDNRPIFLQSS--YEASVPEDIPEGHSILQLK 1130
Score = 101 bits (241), Expect = 3e-20
Identities = 175/724 (24%), Positives = 284/724 (39%), Gaps = 83/724 (11%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGK-VKAVDPDLGQNGMV-LYDLQRTSN 504
+ ++D NDN P F S Y ++ A+VG + ++ VD D G N M +Y + S+
Sbjct: 343 ILVIDINDNAPEFNSSE-YSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSH 401
Query: 505 LTITSPFKINPNTGT-VSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRGT 563
I SP + + VA E + + P Y+ +T+
Sbjct: 402 HFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDN 461
Query: 564 KGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVPFA 621
+ P F Y + NV +GTSV + NDA +VSY + F+
Sbjct: 462 R------PIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR---FS 512
Query: 622 VEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAH 681
+++ +G+I ++ L + +A ++ ++V+DVND K A+
Sbjct: 513 LDKDTGLIMLIARLDYELIQRFTLTIIA-RDGGGEETTGRVRINVLDVNDNVPTFQKDAY 571
Query: 682 SPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTD--DIAIAED-GTI 738
+ ++EN ++ Q+ + + + I + DI++ E G I
Sbjct: 572 ---VGALRENEP--SVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVI 626
Query: 739 FTQKPLDREK--RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFI 796
+PLD E+ + +TV+A + G VTI + DENDNPP F Y +
Sbjct: 627 SVSRPLDYEQISNGLIYLTVMA-MDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSV 685
Query: 797 MENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE 856
+EN G + N + E +Y+L EG F ++ +G + LDRE
Sbjct: 686 VENIMAGATVLFLNATDLDRSREYGQESIIYSL--EGSTQFRINARSGEITTTS-LLDRE 742
Query: 857 KKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGF 916
K SE LI+ D + N K I T
Sbjct: 743 TK----------------SEYILIVRAVDGG--------VGHNQKTGI-------ATVNI 771
Query: 917 TIIEVKPKNKFALDVDQLGPLFL-IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVY 975
T++++ + D P ++ + E P + + + A+D D G NG + Y
Sbjct: 772 TLLDINDNHPTWKDA----PYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ---- 823
Query: 976 IPPSKL-SADALEVKRYFVINERHGHVIVARSLPPESEF--RLNISALDGGN--LNDNIS 1030
PP+K S ++ K I H + P E+E ++ +S D G L S
Sbjct: 824 -PPNKFYSLNSTTGK----IRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSS 878
Query: 1031 VRVFVK--DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
VFV D+ND+ P F+ + V E + +V A D D G N ++Y +
Sbjct: 879 ATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGM 938
Query: 1089 TDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
+ F I+ +GV+ ELDRE +Y L VVA D G DVND +
Sbjct: 939 PRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAG-TPTKSSTSTLTIHVLDVNDET 997
Query: 1149 PKFY 1152
P F+
Sbjct: 998 PTFF 1001
Score = 101 bits (241), Expect = 3e-20
Identities = 120/487 (24%), Positives = 199/487 (40%), Gaps = 44/487 (9%)
Query: 427 TKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVD 486
T T+ +L S V V + D NDN P F F + + + G + A D
Sbjct: 1717 TATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEV-TEGQPGPRVWTFLAHD 1775
Query: 487 PDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVE----ASDQP 542
D G NG V Y + L F I+P G + V + L+ F A D+
Sbjct: 1776 RDSGPNGQVEYSIMDGDPL---GEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRG 1832
Query: 543 ANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE 602
P + + +++ N D P + P + N + + V + +DA
Sbjct: 1833 MPPLSSTMLVGIRVLDI------NDND-PVLLNLPMNITISENSPVSSFVAHVLASDADS 1885
Query: 603 QND--VSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT 660
+ +++++ G E F + +G++TV L R P Y N I
Sbjct: 1886 GCNARLTFNITAGNRERA-FFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIAR 1944
Query: 661 N----ATVHVVDVNDERGVLLKGAHSPIIFHVKENS-AGAAI----GQIFHTNMSS-IYG 710
+ + D ND + K + V ENS AG + G I + IY
Sbjct: 1945 RDYDLLLIFLSDENDNHPLFTKSTYQA---EVMENSPAGTPLTVLNGPILALDADQDIYA 2001
Query: 711 NGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDRE--KRDVYRMTVIAEFNKGVISGA 768
T + + D+ + T+ + +DRE + + ++AE + G+++
Sbjct: 2002 VVTYQLLGAQSGLFDINSSTGVV---TVRSGVIIDREAFSPPILELLLLAE-DIGLLNST 2057
Query: 769 GIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYT 828
+TI D+NDN P F AT ++EN G + + ATD D G N +Y
Sbjct: 2058 AHLLITIL--DDNDNRPTFSPATLTVHLLENCPPGFSVLQ---VTATDEDSGLNGELVYR 2112
Query: 829 LFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDE 886
+ ++ F + TGV++ ++DRE++ Y+L++VA D G LS A + I+I D
Sbjct: 2113 IEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDI 2172
Query: 887 NDNKPEF 893
ND++PEF
Sbjct: 2173 NDSRPEF 2179
Score = 99.1 bits (236), Expect = 1e-19
Identities = 183/777 (23%), Positives = 305/777 (39%), Gaps = 88/777 (11%)
Query: 582 VGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRP 641
+ + +G+SV Q+ D ND + G E FAVE +GV+ + L R +
Sbjct: 42 ISEDTPVGSSVTQLLAQDM--DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKS 99
Query: 642 MYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIF 701
+ E ++ ++ + I + V DVND +S I V IF
Sbjct: 100 EFTVE-FSVSDHQGV-ITRKVNIQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIF 157
Query: 702 HTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEF 760
N + G+V + Q + AI + G + + LD E Y++TV A
Sbjct: 158 IVNATDPDLGAGGSVLYSF---QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATD 214
Query: 761 NKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEG 820
+ + + I I D D P+F + Y I E+S GT ++ II A D D+G
Sbjct: 215 QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR---IITAIDQDKG 271
Query: 821 TNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELI 880
YT+ V NT + +LD ++ L+ R+ L S ++
Sbjct: 272 RPRGIGYTIVS-------VAGNTNSIF----ALDYISGVLTLNGLLDRENP-LYSHGFIL 319
Query: 881 IMIGDE-NDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFL 939
+ G E ND+ R + + T +I++ N A + +
Sbjct: 320 TVKGTELNDD-------------RTPSDATVTTTFNILVIDI---NDNAPEFNSSEYSVA 363
Query: 940 IPENIPIGTTI-IKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERH 998
I E +G + + + +D D GLN EVY+ + ++ + V +
Sbjct: 364 ITELAQVGFALPLFIQVVDKDEGLNSMF------EVYLVGN--NSHHFIISPTSVQGKAD 415
Query: 999 GHVIVARSLPPESEFRLNISALDGGNLNDNIS---VRVFVKDVNDHFPVFKKTWYNFNVE 1055
+ VA L E+ R + ++ D++ V++ + + ND+ P+F + YN ++
Sbjct: 416 IRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLY 475
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E + V ATD D G ++YF SD F + TG++ + LD E +
Sbjct: 476 ENVTVGTSVLTVLATDNDAGTFGEVSYFF--SDDPDRFSLDKDTGLIMLIARLDYELIQR 533
Query: 1116 YILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY--AFDELLEWKHPEADEL----- 1168
+ LT++ARD G DVNDN P F A+ L P +L
Sbjct: 534 FTLTIIARDGG---GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRA 590
Query: 1169 -------SNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQR 1221
+N S++ + + + + G V V + D+ NGLI ++
Sbjct: 591 TDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISV-SRPLDYEQISNGLIYLTV--- 646
Query: 1222 KNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL 1281
+ G P L+ST + + V D E + P F Y + + EN+ A ++ LN
Sbjct: 647 -MAMDAGNPPLNSTVPVTIEVFD-----ENDNPPTFSKPAYFVSVVENIMAGATVLFLNA 700
Query: 1282 T--EHYENFKMRYYILN-ENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
T + + I + E T R I+ R+G + DRE K Y +IVRA
Sbjct: 701 TDLDRSREYGQESIIYSLEGSTQFR----INARSGEITTTSLLDRETKSEYILIVRA 753
Score = 97.1 bits (231), Expect = 4e-19
Identities = 117/419 (27%), Positives = 173/419 (41%), Gaps = 53/419 (12%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
E IP G +I ++ A+DLD GLNG + Y V +P + F+IN G V
Sbjct: 906 EGIPAGVSIYQVVAIDLDEGLNGLVSYRM--PVGMP-----------RMDFLINSSSGVV 952
Query: 1002 IVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ L E +E++L + A D G + ++ + V DVND P F YN +V E
Sbjct: 953 VTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSED 1012
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYI 1117
+ ++ TD D G NA L+YFI + D F + V+ LDRET Y+
Sbjct: 1013 VPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYM 1072
Query: 1118 LTVVARDNG-XXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESV 1176
L + A DNG DVNDN P F E PE D H S+
Sbjct: 1073 LILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIF--LQSSYEASVPE-DIPEGH---SI 1126
Query: 1177 MMIPVYKATIEENAPIGTTVAKVFAND--TDF-IGNGNGLILYS---LPQRKNQQ----- 1225
+ + KAT + G ++ + +F I NGL++ L + +N
Sbjct: 1127 LQL---KATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIV 1183
Query: 1226 ---NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYY-ELEIEENVNAPVELVSLNL 1281
N L + S+ ++V V D+ DE PVF + Y L + E ++ +
Sbjct: 1184 EAYNHDLGPMRSSVRVIVYVEDINDEA-----PVFTQQQYSRLGLRETAGIGTSVIVVQA 1238
Query: 1282 TEH--YENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
T+ + + Y IL + F ID G + V D E K +Y + V A Q
Sbjct: 1239 TDRDSGDGGLVNYRIL----SGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQ 1293
Score = 89.8 bits (213), Expect = 6e-17
Identities = 91/332 (27%), Positives = 145/332 (43%), Gaps = 24/332 (7%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF---IFLIAPIGPSLTIPLTVPRGLT 139
V + + DVNDN P F + PY V + E+ TG IF++ P L +V
Sbjct: 118 VNIQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQ 177
Query: 140 IFKDIRAFDRDKPN-TPNSDVHYSIVSGNDDGHFALESSH-KPVLLLRK--VLDYDAGDK 195
A D + T ++ Y A + +P+ L ++ D D
Sbjct: 178 PPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDM 237
Query: 196 EFQLVIMASGKRIHKEI---LFPEPIHAIDQDLGVGATLRYELIS--GNDRKLFSLDSVN 250
+ + + I++ I AIDQD G + Y ++S GN +F+LD ++
Sbjct: 238 DPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNTNSIFALDYIS 297
Query: 251 GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV----EIELLDLNDNLPEF 306
G L L LD E+ L ++ F+L V+ ++LN+ + A V I ++D+NDN PEF
Sbjct: 298 GVLTLNGLLD--RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEF 355
Query: 307 EVDFYNISIVENLPNGFSV-LQVMATDKDQGENGEF-TYQLDDPKGAFSIDPRS----GW 360
Y+++I E GF++ L + DKD+G N F Y + + F I P S
Sbjct: 356 NSSEYSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSHHFIISPTSVQGKAD 415
Query: 361 LTVRNQTVLDREAHSSLRMKVYAKETNPSVVG 392
+ +R LD E ++A E+ P VG
Sbjct: 416 IRIRVAIPLDYETVDRYDFDLFANESVPDHVG 447
Score = 87.0 bits (206), Expect = 5e-16
Identities = 134/517 (25%), Positives = 211/517 (40%), Gaps = 72/517 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPE+ P+G + + A D D+G NGQ+ V+ S A A E+ N+ G
Sbjct: 1433 IPEDCPVGQRVATVKAWDPDAGSNGQV-------VFSLASGNIAGAFEI---VTTNDSIG 1482
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFKKTW-YNFN 1053
V VAR L E + L + A D G D+I ++V + D+ND+ PV + + YN +
Sbjct: 1483 EVFVARPLDREELDHYILQVVASDRGTPPRKKDHI-LQVTILDINDNPPVIESPFGYNVS 1541
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVN-GELDRET 1112
V E + +V ATD D G N+ L+Y+I + D+ F + ++G ++ DRE
Sbjct: 1542 VNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRER 1601
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYA--FDELLEWKHPEADELSN 1170
+ Y L D G D NDN+P F ++ LL+ + P+ S
Sbjct: 1602 QSFYHLVATVEDEG-TPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLD-EGPDTLNTSL 1659
Query: 1171 HNFESVMMIPVYKATIEENAPIGTTV----------AKVFANDTDF-IGNGNGLILYSLP 1219
+++ + T+ G V A + D+ I +G ++ +
Sbjct: 1660 ITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVT-- 1717
Query: 1220 QRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSL 1279
+Q + L+ST ++V V D+ D V P F R YE E P V
Sbjct: 1718 -ATDQCPILSHRLTSTTTVLVNVNDINDNV-----PTF-PRDYEGPFEVTEGQPGPRVWT 1770
Query: 1280 NLTEHYE---NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSP--DREVKDTYEVIVR 1334
L + N ++ Y I+ D D FVI P G L + + DRE Y + +
Sbjct: 1771 FLAHDRDSGPNGQVEYSIM---DGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTIC 1827
Query: 1335 AERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTT 1394
A R +P P++ +L G +R+ D+NDN P N P+ I
Sbjct: 1828 AR----DRGMP----PLSSTMLVG---------IRVLDINDNDPVLL--NLPMNITISEN 1868
Query: 1395 AP---FGYQVMQLKGAIGHHPTASRTVRADTDELVFF 1428
+P F V+ G + + + A E FF
Sbjct: 1869 SPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFF 1905
Score = 86.2 bits (204), Expect = 8e-16
Identities = 62/205 (30%), Positives = 92/205 (44%), Gaps = 7/205 (3%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I A+D D G T+ Y +++GN F +D G + KELD + H Q
Sbjct: 1662 IQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQ 1721
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN-ISIVENLPNGFSVLQVMATDKDQG 336
L++ L T+ V + + D+NDN+P F D+ + E P G V +A D+D G
Sbjct: 1722 CPILSHRL-TSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP-GPRVWTFLAHDRDSG 1779
Query: 337 ENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETN-PSVVGT 393
NG+ Y + DP G F I P G L VR LDRE + + + A++ P + T
Sbjct: 1780 PNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSST 1839
Query: 394 FADSQRIAKWR-RQPLETNAPLEKT 417
R+ P+ N P+ T
Sbjct: 1840 MLVGIRVLDINDNDPVLLNLPMNIT 1864
Score = 81.4 bits (192), Expect = 2e-14
Identities = 113/492 (22%), Positives = 204/492 (41%), Gaps = 54/492 (10%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + +LD ND P F + S+ N GT + + A D D G NG + Y L+
Sbjct: 2498 VQVVIQVLDVNDCRPQFSKPQ-FSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGP 2556
Query: 503 SNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F ++ ++G V+ + +L V A+D P L V I+V
Sbjct: 2557 G----VEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVN-- 2610
Query: 563 TKGNKPDIPDFMGAPYE--FWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLH--GYEE 616
N+P F+ P + + + ++V ++ D E V Y L G +
Sbjct: 2611 --DNRPV---FVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRD 2665
Query: 617 GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV--DVNDERG 674
F ++ SG+I L R ++ +Y VA + T + V D++D
Sbjct: 2666 WEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEP 2725
Query: 675 VLL---KGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
+ + KG+ + V E+S G +G + + + G F+ A ++ +
Sbjct: 2726 LFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGA-VDADEGPNAIVYYFIAAGNEE--KNF 2782
Query: 731 AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKG------------VISGAGIYQVTIYIE 778
+ DG + + LDRE+ ++ V A N+ +++ + +V + +E
Sbjct: 2783 HLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLE 2842
Query: 779 DENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG--EGKEM 836
D ND PP F A Y + ++K+G+E+ + A DAD G N+L Y++ + +
Sbjct: 2843 DINDQPPRFTKAEYTAGVATDAKVGSELIQ---VLALDADIGNNSLVFYSILAIHYFRAL 2899
Query: 837 FDVDENTGVVKFIG--DSLDREKKIM-------YKLSLVARDTGGLSSEAEL-IIMIGDE 886
+ E+ G V +G D + R + + + +VARD G + A + I ++ D+
Sbjct: 2900 ANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDD 2959
Query: 887 NDNKPEFNQIEE 898
K N+I +
Sbjct: 2960 QRVKIVINEIPD 2971
Score = 80.6 bits (190), Expect = 4e-14
Identities = 47/148 (31%), Positives = 78/148 (52%), Gaps = 4/148 (2%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G A + Y L G + F+++ G +++ LD + + +
Sbjct: 2429 VTATDADSGNFALIEYSLGDGESK--FAINPTTGDIYVLSSLDREKKDHYILTALAKDNP 2486
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
+N + + +V I++LD+ND P+F ++ S+ EN P G SV+ +MATD+D+G
Sbjct: 2487 GDVASNRRENS-VQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGP 2545
Query: 338 NGEFTYQLDDP-KGAFSIDPRSGWLTVR 364
NGE TY L+ P AF +D SG +T +
Sbjct: 2546 NGELTYSLEGPGVEAFHVDMDSGLVTTQ 2573
Score = 80.2 bits (189), Expect = 5e-14
Identities = 128/492 (26%), Positives = 206/492 (41%), Gaps = 65/492 (13%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
E++P+GT I+ + A D DSG I Y E K F IN G +
Sbjct: 2418 EDVPVGTIILTVTATDADSGNFALIEYSLGDG-------------ESK--FAINPTTGDI 2462
Query: 1002 IVARSLPPESEFRLNISALDGGNLND--------NISVRVFVKDVNDHFPVFKKTWYNFN 1053
V SL E + ++AL N D ++ V + V DVND P F K ++ +
Sbjct: 2463 YVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTS 2522
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETE 1113
V E + + + ATD D G N LTY ++ + F + +G+++ L ++
Sbjct: 2523 VYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA-FHVDMDSGLVTTQRPL--QSY 2579
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNF 1173
+K+ LTVVA D G DVNDN P F E L ++ +
Sbjct: 2580 EKFSLTVVATDGGEPPLWGTTMLLVEVI-DVNDNRPVFVRPPNGTILHIREEIPLRSNVY 2638
Query: 1174 ESVMMIPVYKATIEE--NAPIGTTVAKVFAN-DTDF--IGNGNGLILYSLPQRKNQQ--- 1225
E VY +E N + + K N D +F I +GLI + + Q
Sbjct: 2639 E------VYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY 2692
Query: 1226 -------NLGLPSLSSTAI-LMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELV 1277
+LG P T L V + D+ D + +P S Y+L + ++P +
Sbjct: 2693 SLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQL-LTVPEHSPRGTL 2751
Query: 1278 SLNLT-----EHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVI 1332
N+T + N + Y+I N+ + F + P +G L ++R DRE + + I
Sbjct: 2752 VGNVTGAVDADEGPNAIVYYFIAAGNE---EKNFHLQP-DGCLLVLRDLDREREAIFSFI 2807
Query: 1333 VRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIP 1392
V+A + S P P D++ +T +V+VV ++D+ND P+FT +
Sbjct: 2808 VKASSNR-SWTPPRGPSPTL-DLVADLTLQEVRVV--LEDINDQPPRFTKAE--YTAGVA 2861
Query: 1393 TTAPFGYQVMQL 1404
T A G +++Q+
Sbjct: 2862 TDAKVGSELIQV 2873
Score = 78.2 bits (184), Expect = 2e-13
Identities = 54/164 (32%), Positives = 84/164 (51%), Gaps = 12/164 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTFVL 274
+ A D D G + + L SGN F + + N G +F+ + LD + + + ++L
Sbjct: 1446 VKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDRE-----ELDHYIL 1500
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDK 333
QV AS P + +++ +LD+NDN P E F YN+S+ EN+ G +V+QV ATD+
Sbjct: 1501 QVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDR 1560
Query: 334 DQGENGEFTYQLDDPKG--AFSIDPRSGWLTVRNQTVLDREAHS 375
D G N +Y + + AF +D SG + R DRE S
Sbjct: 1561 DIGINSVLSYYITEGNKDMAFRMDRISGEIATR-PAPPDRERQS 1603
Score = 77.8 bits (183), Expect = 3e-13
Identities = 54/177 (30%), Positives = 86/177 (48%), Gaps = 9/177 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSL-DSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A+D D G+ + Y L+ L DS G + + +D + H L V
Sbjct: 2323 VAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLN-----FTV 2377
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+AS +P + A+ V +E++D+NDN P F+ Y ++ E++P G +L V ATD D G
Sbjct: 2378 RASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSG 2437
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
Y L D + F+I+P +G + V + LDRE + AK+ NP V +
Sbjct: 2438 NFALIEYSLGDGESKFAINPTTGDIYVLSS--LDREKKDHYILTALAKD-NPGDVAS 2491
Score = 76.2 bits (179), Expect = 9e-13
Identities = 81/326 (24%), Positives = 133/326 (40%), Gaps = 21/326 (6%)
Query: 77 ISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIA------PIGPSLTI 130
+S ++ + I DV D PIF++ PY + E +P G I P G TI
Sbjct: 221 LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI 280
Query: 131 PLTVPRGLTIF-----KDIRAFDR--DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLL 183
+IF + + D+ N S V G + S
Sbjct: 281 VSVAGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTT 340
Query: 184 LR-KVLDYDAGDKEFQLVIMASGKRIHKEILFPEP--IHAIDQDLGVGATLRYELISGND 240
V+D + EF + ++ F P I +D+D G+ + L+ N
Sbjct: 341 FNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNS 400
Query: 241 RK-LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
+ S SV G + + + ++ + + + A++ + P A+V+I L++
Sbjct: 401 HHFIISPTSVQGKADIRIRVAIPLDYET-VDRYDFDLFANE-SVPDHVGYAKVKITLINE 458
Query: 300 NDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSG 359
NDN P F YNIS+ EN+ G SVL V+ATD D G GE +Y D FS+D +G
Sbjct: 459 NDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTG 518
Query: 360 WLTVRNQTVLDREAHSSLRMKVYAKE 385
+ + + LD E + + A++
Sbjct: 519 LIMLIAR--LDYELIQRFTLTIIARD 542
Score = 73.7 bits (173), Expect = 5e-12
Identities = 87/331 (26%), Positives = 138/331 (41%), Gaps = 22/331 (6%)
Query: 73 GLNQISAYLSVTVYIE--DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLT- 129
G + A S TV++ D+NDN P F + P+ V E P G + + + L
Sbjct: 869 GRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNG 928
Query: 130 -----IPLTVPRGLTIFKDIRAFDRDKPNTPNSDV-HYSIVSGNDDGHFALESSHKPVLL 183
+P+ +PR + + Y + D +SS + +
Sbjct: 929 LVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTI 988
Query: 184 LRKVLDY-DAGDKEFQLVIMAS-GKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDR 241
VLD D F V S + + +E ++ D D+G+ A L Y + GN
Sbjct: 989 --HVLDVNDETPTFFPAVYNVSVSEDVPREFRVVW-LNCTDNDVGLNAELSYFITGGNVD 1045
Query: 242 KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLND 301
FS+ + + + LD E A +L+ + T A V + +LD+ND
Sbjct: 1046 GKFSVGYRDA--VVRTVVGLDRE-TTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVND 1102
Query: 302 NLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSG 359
N P F Y S+ E++P G S+LQ+ ATD D+GE G Y++ + F I +G
Sbjct: 1103 NRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNG 1162
Query: 360 WLTVRNQTVLDREAHSS--LRMKVYAKETNP 388
L +R LDRE +SS L ++ Y + P
Sbjct: 1163 -LLMRGPRPLDRERNSSHVLIVEAYNHDLGP 1192
Score = 70.9 bits (166), Expect = 3e-11
Identities = 122/490 (24%), Positives = 195/490 (39%), Gaps = 62/490 (12%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN+ GT ++++ A D D G+N + Y YI A + R + E
Sbjct: 1542 VNENVGGGTAVVQVRATDRDIGINSVLSY------YITEGNKDM-AFRMDR--ISGE--- 1589
Query: 1000 HVIVARSLPPESE----FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFN 1053
I R PP+ E + L + D G L+ V V + D ND+ P+F++ Y
Sbjct: 1590 --IATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVL 1647
Query: 1054 VEEAQYTRRV-LGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRE- 1111
++E T L + A D D G N +TY I + F I GV++ ELD E
Sbjct: 1648 LDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEI 1707
Query: 1112 TEDKYILTVVARDNG--XXXXXXXXXXXXXXXXDVNDNSPKF---YA--FDELLEWKHPE 1164
+ +Y L V A D D+NDN P F Y F+ P
Sbjct: 1708 SHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPR 1767
Query: 1165 ADELSNHNFESVMMIPVYKATIEENAPIG----TTVAKVFANDTDFIGNGNGLILYSLPQ 1220
H+ +S V + +I + P+G + V V D + + Y+L
Sbjct: 1768 VWTFLAHDRDSGPNGQV-EYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTI 1826
Query: 1221 RKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVS 1278
+ G+P LSST ++ + V D+ D + PV ++ + I EN V++ V V
Sbjct: 1827 CARDR--GMPPLSSTMLVGIRVLDIND-----NDPVLLNLPMNITISENSPVSSFVAHVL 1879
Query: 1279 LNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
+ + N ++ + I N R F I+ G + + R DRE Y++ +
Sbjct: 1880 ASDADSGCNARLTFNITAGNR---ERAFFINATTGIVTVNRPLDRERIPEYKLTISV--- 1933
Query: 1339 KYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFG 1398
K + E P + YD+ +++ + D NDN P FT + +P G
Sbjct: 1934 KDNPENPRI----------ARRDYDL-LLIFLSDENDNHPLFTKST--YQAEVMENSPAG 1980
Query: 1399 YQVMQLKGAI 1408
+ L G I
Sbjct: 1981 TPLTVLNGPI 1990
Score = 70.9 bits (166), Expect = 3e-11
Identities = 88/331 (26%), Positives = 134/331 (40%), Gaps = 23/331 (6%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIA---PIGPSLT 129
G +SA V V I D NDN P+F Y V +DE T + I + A GP+ T
Sbjct: 1615 GTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGT 1674
Query: 130 IPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR---- 185
+ + G I R T ++ Y I G + P+L R
Sbjct: 1675 VTYAIVAG-NIVNTFRIDRHMGVITAAKELDYEISHGRYT-LIVTATDQCPILSHRLTST 1732
Query: 186 KVLDYDAGDKEFQLVIMASGKRIHKEILFPEP------IHAIDQDLGVGATLRYELISGN 239
+ + D + E+ +P A D+D G + Y ++ G+
Sbjct: 1733 TTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGD 1792
Query: 240 DRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
F + V G L + K+++LD E N L + A P ++ V I +LD+
Sbjct: 1793 PLGEFVISPVEGVLRVRKDVELDRETIAFYN---LTICARDRGMPPLSSTMLVGIRVLDI 1849
Query: 300 NDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPR 357
NDN P NI+I EN P V V+A+D D G N T+ + + + AF I+
Sbjct: 1850 NDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINAT 1909
Query: 358 SGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
+G +TV LDRE ++ + K+ NP
Sbjct: 1910 TGIVTVNRP--LDRERIPEYKLTISVKD-NP 1937
Score = 67.3 bits (157), Expect = 4e-10
Identities = 54/173 (31%), Positives = 80/173 (46%), Gaps = 8/173 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G + Y ++ GN F + NG L + LD E N ++ VL V+
Sbjct: 1129 LKATDADEGEFGRVWYRILHGNHGNNFRIHVSNG-LLMRGPRPLDRERN---SSHVLIVE 1184
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN-ISIVENLPNGFSVLQVMATDKDQG 336
A + + RV + + D+ND P F Y+ + + E G SV+ V ATD+D G
Sbjct: 1185 AYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSG 1244
Query: 337 ENGEFTYQ-LDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
+ G Y+ L +G F ID +G + N LD E +S M V A + P
Sbjct: 1245 DGGLVNYRILSGAEGKFEIDESTGLIITVN--YLDYETKTSYMMNVSATDQAP 1295
Score = 63.7 bits (148), Expect = 5e-09
Identities = 59/211 (27%), Positives = 92/211 (43%), Gaps = 31/211 (14%)
Query: 929 LDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEF-------NSEV 974
LDV+ P+FL +PE+IP G +I++L A D D G G++ Y N +
Sbjct: 1098 LDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRI 1157
Query: 975 YIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVF 1034
++ L + R HV++ + D G + ++ V V+
Sbjct: 1158 HVSNGLLMRGPRPLDR----ERNSSHVLIVEAYNH-----------DLGPMRSSVRVIVY 1202
Query: 1035 VKDVNDHFPVFKKTWYN-FNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPF 1093
V+D+ND PVF + Y+ + E + V ATD D G + Y I S + F
Sbjct: 1203 VEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRIL-SGAEGKF 1261
Query: 1094 EISPLTGVLSVNGELDRETEDKYILTVVARD 1124
EI TG++ LD ET+ Y++ V A D
Sbjct: 1262 EIDESTGLIITVNYLDYETKTSYMMNVSATD 1292
Score = 62.9 bits (146), Expect = 9e-09
Identities = 53/170 (31%), Positives = 77/170 (45%), Gaps = 8/170 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGND-RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D+D + Y ++S + F + G + LD E + L V
Sbjct: 588 LRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ-ISNGLIYLTV 646
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A NP + V IE+ D NDN P F Y +S+VEN+ G +VL + ATD D+
Sbjct: 647 MAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRS 706
Query: 337 -ENGE--FTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
E G+ Y L+ F I+ RSG +T ++LDRE S + V A
Sbjct: 707 REYGQESIIYSLEG-STQFRINARSGEIT--TTSLLDRETKSEYILIVRA 753
Score = 62.9 bits (146), Expect = 9e-09
Identities = 46/175 (26%), Positives = 77/175 (44%), Gaps = 10/175 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D+D+G+ + L Y + GN F +D ++G + + D E + + L
Sbjct: 1555 VRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEI-ATRPAPPDRERQ---SFYHLVAT 1610
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN-GFSVLQVMATDKDQG 336
P +A V + ++D NDN P F+ Y + + E S++ + A D D+G
Sbjct: 1611 VEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEG 1670
Query: 337 ENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDRE-AHSSLRMKVYAKETNP 388
NG TY + + F ID G +T + LD E +H + V A + P
Sbjct: 1671 PNGTVTYAIVAGNIVNTFRIDRHMGVITAAKE--LDYEISHGRYTLIVTATDQCP 1723
Score = 61.7 bits (143), Expect = 2e-08
Identities = 59/203 (29%), Positives = 92/203 (45%), Gaps = 23/203 (11%)
Query: 935 GPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVI 994
G + I E IP+ + + ++ A D D GLNG +RY F L +F+I
Sbjct: 2622 GTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSF----------LKTAGNRDWEFFII 2671
Query: 995 NERHGHVIVARSLPPESE--FRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFKK-- 1047
+ G + A+ L ES+ + L + A D G ++V ++D++D+ P+F +
Sbjct: 2672 DPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPP 2731
Query: 1048 ----TWYNFNVEEAQYTRRVLGKV-DATDADFGQNANLTYFIQPSDTDLPFEISPLTGVL 1102
+ V E ++G V A DAD G NA + YFI + + F + P G L
Sbjct: 2732 KGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCL 2790
Query: 1103 SVNGELDRETEDKYILTVVARDN 1125
V +LDRE E + V A N
Sbjct: 2791 LVLRDLDREREAIFSFIVKASSN 2813
Score = 60.5 bits (140), Expect = 5e-08
Identities = 36/141 (25%), Positives = 67/141 (47%), Gaps = 5/141 (3%)
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
N F+++ GS+ ++ ++ + + V+ + + A++ + +LD
Sbjct: 2231 NQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLD 2290
Query: 299 LNDNLPEFE---VDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD--PKGAFS 353
+NDN P+F+ + +Y I+E G +++ V A D D+G NG TY L D P G
Sbjct: 2291 VNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQ 2350
Query: 354 IDPRSGWLTVRNQTVLDREAH 374
++ S + N+TV E H
Sbjct: 2351 LEDSSAGKVIANRTVDYEEVH 2371
Score = 58.4 bits (135), Expect = 2e-07
Identities = 41/126 (32%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D G + Y DR FSLD G + L LD + F L + A
Sbjct: 489 ATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYEL-----IQRFTLTIIAR 541
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
T RV I +LD+NDN+P F+ D Y ++ EN P+ ++++ ATD+D N
Sbjct: 542 DGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNN 599
Query: 340 EFTYQL 345
+ TY +
Sbjct: 600 QITYSI 605
Score = 58.4 bits (135), Expect = 2e-07
Identities = 114/498 (22%), Positives = 199/498 (39%), Gaps = 50/498 (10%)
Query: 83 VTVYIE--DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI--APIGPSLTIPLTVPRGL 138
+ VY+E D+NDN PIF Y V E P G A G I ++ G
Sbjct: 2391 IPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGE 2450
Query: 139 TIFK------DI---RAFDRDKPNTPNSDVHYSI--VSGNDDGHFALESSHKPVLLLRKV 187
+ F DI + DR+K + HY + ++ ++ G A V ++ +V
Sbjct: 2451 SKFAINPTTGDIYVLSSLDREKKD------HYILTALAKDNPGDVASNRRENSVQVVIQV 2504
Query: 188 LDYDAGDKEFQLVIMASGKRIHKEI-LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSL 246
LD + +F ++ ++ + A DQD G L Y L G + F +
Sbjct: 2505 LDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHV 2563
Query: 247 DSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF 306
D +G + ++ L F L V A+ P + +E++D+NDN P F
Sbjct: 2564 DMDSGLVTTQRPLQ-------SYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVF 2616
Query: 307 --EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKG-----AFSIDPRSG 359
+ + I E +P +V +V ATDKD+G NG Y G F IDP SG
Sbjct: 2617 VRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISG 2676
Query: 360 WLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGTFADSQRIAKWRRQPLETNAPLEKTTY 419
+ + LDRE+ + + + A + V ++A + ++ N PL +
Sbjct: 2677 LIQTAQR--LDRESQAVYSLILVASDLGQPVPYETMQPLQVA---LEDIDDNEPL----F 2727
Query: 420 VFPDKVGTKTENIEYYDEQLMSFVNVEVT-LLDANDNNPVFVPSNLYEFSMKSNAKVGTV 478
V P K + + + + + VT +DA++ V + + + N +
Sbjct: 2728 VRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD 2787
Query: 479 IGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEA 538
+ D D + + + ++ +SN + T P +P T+ + L+ + +
Sbjct: 2788 GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSP---TLDLVADLTLQEVRVVLEDI 2844
Query: 539 SDQPANPSERRYSLAVVT 556
+DQP ++ Y+ V T
Sbjct: 2845 NDQPPRFTKAEYTAGVAT 2862
Score = 54.0 bits (124), Expect = 4e-06
Identities = 43/156 (27%), Positives = 72/156 (46%), Gaps = 16/156 (10%)
Query: 236 ISGNDR-KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
+SG + + F+++ G ++L + LD + + + F ++ S + +V I
Sbjct: 69 VSGEEASRFFAVEPDTGVVWLRQPLDRETK-----SEFTVEFSVSDHQGVITR---KVNI 120
Query: 295 ELLDLNDNLPEFEVDFYNISIVE-----NLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
++ D+NDN P F Y++ I E N P G + V ATD D G G Y P
Sbjct: 121 QVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS 180
Query: 350 GAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
F+ID G +TV + LD E + ++ V A +
Sbjct: 181 QFFAIDSARGIVTVIRE--LDYETTQAYQLTVNATD 214
Score = 50.0 bits (114), Expect = 6e-05
Identities = 39/129 (30%), Positives = 62/129 (48%), Gaps = 10/129 (7%)
Query: 230 TLRYELISGNDRK-LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTA 288
T R+ + K LF +D++ G + ++ +D + + + + L V A P +
Sbjct: 1352 TYRFNAYTSTQAKALFKIDAITGVITVQGLVDRE-----KGDFYTLTVVADD-GGPKVDS 1405
Query: 289 QARVEIELLDLNDNLPEFEVDFYN-ISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-- 345
+V I +LD NDN P F+ + +SI E+ P G V V A D D G NG+ + L
Sbjct: 1406 TVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLAS 1465
Query: 346 DDPKGAFSI 354
+ GAF I
Sbjct: 1466 GNIAGAFEI 1474
Score = 49.2 bits (112), Expect = 1e-04
Identities = 79/323 (24%), Positives = 135/323 (41%), Gaps = 34/323 (10%)
Query: 81 LSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIA--PIGPS--LTIPLTVP- 135
+ V + + DVND P F + +V E P G + GP+ LT L P
Sbjct: 2498 VQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPG 2557
Query: 136 -RGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
+ D +P ++V+ D G L + +LL +V+D +
Sbjct: 2558 VEAFHVDMDSGLVTTQRPLQSYEKFSLTVVA-TDGGEPPLWGT---TMLLVEVIDVNDNR 2613
Query: 195 KEFQLVIMASGKRIHKEILFPE---PIHAIDQDLGVGATLRYELI--SGN-DRKLFSLDS 248
F + I +EI ++A D+D G+ +RY + +GN D + F +D
Sbjct: 2614 PVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDP 2673
Query: 249 VNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPL--KTAQARVEIELLDLNDNLPEF 306
++G + + LD +++ + L + AS L P+ +T Q +++ L D++DN P F
Sbjct: 2674 ISGLIQTAQRLDRESQ-----AVYSLILVASDLGQPVPYETMQP-LQVALEDIDDNEPLF 2727
Query: 307 ------EVDFYNISIVENLPNGFSVLQVM-ATDKDQGENGEFTYQL--DDPKGAFSIDPR 357
+ +++ E+ P G V V A D D+G N Y + + + F + P
Sbjct: 2728 VRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP- 2786
Query: 358 SGWLTVRNQTVLDREAHSSLRMK 380
G L V +REA S +K
Sbjct: 2787 DGCLLVLRDLDREREAIFSFIVK 2809
Score = 45.2 bits (102), Expect = 0.002
Identities = 35/137 (25%), Positives = 61/137 (44%), Gaps = 15/137 (10%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G A + Y + +GN+ K F L +G L + ++LD + E +F+++ ++
Sbjct: 2758 AVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIF---SFIVKASSN 2813
Query: 280 QLNNPLKTAQA-----------RVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQV 328
+ P + V + L D+ND P F Y + + G ++QV
Sbjct: 2814 RSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQV 2873
Query: 329 MATDKDQGENGEFTYQL 345
+A D D G N Y +
Sbjct: 2874 LALDADIGNNSLVFYSI 2890
Score = 44.8 bits (101), Expect = 0.002
Identities = 44/152 (28%), Positives = 72/152 (47%), Gaps = 28/152 (18%)
Query: 1233 SSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN--FKM 1290
+ TA + VTV DV D ++P+F+ YE + E++ ++ L T+ E ++
Sbjct: 1088 TGTATVFVTVLDVND-----NRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRV 1142
Query: 1291 RYYILNENDTDIRRTFVIDPRNGTLYLVRSP-DREVKDTYEVIVRAERQKYSRELPHMIY 1349
Y IL+ N + F I NG L P DRE ++ +IV A Y+ +L
Sbjct: 1143 WYRILHGNHGN---NFRIHVSNGLLMRGPRPLDRERNSSHVLIVEA----YNHDL----- 1190
Query: 1350 PVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
G + V+V+V ++D+ND +P FT
Sbjct: 1191 --------GPMRSSVRVIVYVEDINDEAPVFT 1214
Score = 40.7 bits (91), Expect = 0.039
Identities = 40/151 (26%), Positives = 67/151 (44%), Gaps = 12/151 (7%)
Query: 79 AYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS----LTIPLTV 134
A S+ + D+ VP P V ++++ + +F+ P G LT+P
Sbjct: 2690 AVYSLILVASDLGQPVPYETMQPLQVALEDID---DNEPLFVRPPKGSPQYQLLTVPEHS 2746
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
PRG + A D D+ PN+ V+Y I +GN++ +F L+ LL+ + LD + +
Sbjct: 2747 PRGTLVGNVTGAVDADEG--PNAIVYYFIAAGNEEKNFHLQPD--GCLLVLRDLDRER-E 2801
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAIDQDL 225
F ++ AS R P P + DL
Sbjct: 2802 AIFSFIVKASSNRSWTPPRGPSPTLDLVADL 2832
Score = 37.5 bits (83), Expect = 0.37
Identities = 19/51 (37%), Positives = 27/51 (52%), Gaps = 4/51 (7%)
Query: 1441 ATDSDIGINADIRYQILNEQAPR----FAIDPVSGTVRVVAALARDAGRVF 1487
ATD D G+N +RY L R F IDP+SG ++ L R++ V+
Sbjct: 2642 ATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY 2692
Score = 35.1 bits (77), Expect = 2.0
Identities = 21/54 (38%), Positives = 27/54 (50%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI 1084
VRV ++D+ND P F K Y V L +V A DAD G N+ + Y I
Sbjct: 2837 VRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSI 2890
Score = 33.5 bits (73), Expect = 6.0
Identities = 16/45 (35%), Positives = 25/45 (55%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTP 111
+V AG S+ ++T+++ DVND P F Y+V+V E P
Sbjct: 970 VVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVP 1014
>AL731541-6|CAI40841.1| 3359|Homo sapiens cadherin-like 23 protein.
Length = 3359
Score = 161 bits (392), Expect = 1e-38
Identities = 140/469 (29%), Positives = 215/469 (45%), Gaps = 25/469 (5%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L + +V VT++D NDN P+F + + + T + ++A+D D G NG V Y
Sbjct: 1619 LSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYA 1678
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAES---PILEGRHALFVEASDQPANPSERRYSLAVV 555
+ + I + F+I+ + G ++ A+ I GR+ L V A+DQ S R S V
Sbjct: 1679 IVAGN---IVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTV 1735
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGS-NVGIGTSVGQIRVNDAFEQNDVSYDLLHGY 614
+ V N P P P+E G + T + R D+ V Y ++ G
Sbjct: 1736 LVNVN-DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDR--DSGPNGQVEYSIMDGD 1792
Query: 615 EEGVPFAVEERSGVITVVDD--LSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVND 671
G F + GV+ V D L R Y+ A LS + V+D+ND
Sbjct: 1793 PLG-EFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDIND 1851
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
VLL + P+ + ENS ++ + H S + F I
Sbjct: 1852 NDPVLL---NLPMNITISENSPVSSF--VAHVLASDADSGCNARLTFNITAGNRERAFFI 1906
Query: 732 IAEDGTIFTQKPLDREKRDVYRMTVIAEFN--KGVISGAGIYQVTIYIEDENDNPPVFEH 789
A G + +PLDRE+ Y++T+ + N I+ + I++ DENDN P+F
Sbjct: 1907 NATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTK 1966
Query: 790 ATYEGFIMENSKIGTEIKMDN-IIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+TY+ +MENS GT + + N I A DAD+ A+ Y L G +FD++ +TGVV
Sbjct: 1967 STYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTV 2026
Query: 849 -IGDSLDRE--KKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFN 894
G +DRE + +L L+A D G L+S A L+I I D+NDN+P F+
Sbjct: 2027 RSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFS 2075
Score = 156 bits (378), Expect = 7e-37
Identities = 254/1016 (25%), Positives = 428/1016 (42%), Gaps = 138/1016 (13%)
Query: 439 LMSFVNVEVTLLDANDNNPVFV--PSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
L S + V + +LD NDN+PV + P N+ ++ N+ V + + V A D D G N +
Sbjct: 1836 LSSTMLVGIRVLDINDNDPVLLNLPMNI---TISENSPVSSFVAHVLASDADSGCNARLT 1892
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR---HALFVEASDQPANP--SERRYS 551
+++ + F IN TG V+V P+ R + L + D P NP + R Y
Sbjct: 1893 FNITAGNR---ERAFFINATTGIVTV-NRPLDRERIPEYKLTISVKDNPENPRIARRDYD 1948
Query: 552 LAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSV----GQIRVNDAFEQ--ND 605
L ++ + + P F + Y+ V N GT + G I DA +
Sbjct: 1949 LLLIFLS------DENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV 2002
Query: 606 VSYDLLHGYEEGVPFAVEERSGVITV----VDDLSRYNRPMYDFEAVALQENANLSIVTN 661
V+Y LL G + G+ F + +GV+TV + D ++ P+ + +A ++ L+ +
Sbjct: 2003 VTYQLL-GAQSGL-FDINSSTGVVTVRSGVIIDREAFSPPILELLLLA-EDIGLLNSTAH 2059
Query: 662 ATVHVVDVNDERGVLLKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLI 720
+ ++D ND R + + + H+ EN G ++ Q+ T+ S G V +
Sbjct: 2060 LLITILDDNDNRPTF---SPATLTVHLLENCPPGFSVLQVTATDEDS--GLNGELVYRIE 2114
Query: 721 ANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDE 780
A QD I + +DRE+++ YR+TV+A ++G + +G VTI I+D
Sbjct: 2115 AGAQD-RFLIHLVTGVIRVGNATIDREEQESYRLTVVAT-DRGTVPLSGTAIVTILIDDI 2172
Query: 781 NDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVD 840
ND+ P F + ++E+++ GT I NI T D N Y + G + D
Sbjct: 2173 NDSRPEFLNPIQTVSVLESAEPGTVIA--NI---TAIDHDLNPKLEYHIVG----IVAKD 2223
Query: 841 ENTGVVKFIGDSLD---REKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIE 897
+ +V D+ +M K S + R+ L + E+ + + D + PE +
Sbjct: 2224 DTDRLVPNQEDAFAVNINTGSVMVK-SPMNRE---LVATYEVTLSVIDNASDLPERSVSV 2279
Query: 898 ENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALD 957
N+K+ ++ + T F KP F + + I E GTT+I + A+D
Sbjct: 2280 PNAKLTVNVLDVNDNTPQF-----KP---FGITYY----MERILEGATPGTTLIAVAAVD 2327
Query: 958 LDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLN- 1016
D GLNG + Y +PP + + + G VI R++ E LN
Sbjct: 2328 PDKGLNGLVTYTLLD--LVPPGYVQLE----------DSSAGKVIANRTVDYEEVHWLNF 2375
Query: 1017 -ISALDGGNLNDNISVRVFVK--DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD 1073
+ A D G+ + V+++ D+ND+ P+F + Y V E ++ V ATDAD
Sbjct: 2376 TVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDAD 2435
Query: 1074 FGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG---XXXX 1130
G A + Y + D + F I+P TG + V LDRE +D YILT +A+DN
Sbjct: 2436 SGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNR 2493
Query: 1131 XXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENA 1190
DVND P+F P+ N + + AT ++
Sbjct: 2494 RENSVQVVIQVLDVNDCRPQF---------SKPQFSTSVYENEPAGTSVITMMATDQDEG 2544
Query: 1191 PIGTTVAKVFANDTD--FIGNGNGLILYSLPQRKNQQ--------NLGLPSLSSTAILMV 1240
P G + + + +GL+ P + ++ + G P L T +L+V
Sbjct: 2545 PNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLV 2604
Query: 1241 TVADVPDEVEMSDKPVFI--SRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILN 1296
V DV D ++PVF+ L I E + + + T+ E N +RY L
Sbjct: 2605 EVIDVND-----NRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLK 2659
Query: 1297 ENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVL 1356
F+IDP +G + + DRE + Y +I+ A + PV + +
Sbjct: 2660 TAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS---------DLGQPVPYETM 2710
Query: 1357 EGMTKYDVKVVVRIKDVNDNSPKFT----NGNRPLVTAIPTTAPFGYQVMQLKGAI 1408
+ + V ++D++DN P F + + +P +P G V + GA+
Sbjct: 2711 QPLQ-------VALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAV 2759
Score = 150 bits (364), Expect = 3e-35
Identities = 256/1011 (25%), Positives = 406/1011 (40%), Gaps = 135/1011 (13%)
Query: 432 IEYYDEQL---MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPD 488
+E Y+ L S V V V + D ND PVF ++ A +GT + V+A D D
Sbjct: 1183 VEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRD 1242
Query: 489 LGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPS 546
G G+V Y + + F+I+ +TG + E + + + V A+DQ A P
Sbjct: 1243 SGDGGLVNYRILSGAE----GKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQ-APPF 1297
Query: 547 ERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDV 606
+ + +T+ + F A YE + N+ +GT + +++ N +
Sbjct: 1298 NQGFCSVYITL------LNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQI 1351
Query: 607 SY--DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
+Y + + F ++ +GVITV + R Y VA + +
Sbjct: 1352 TYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYI 1411
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGT-GNVRFLIANQ 723
V+D ND + S + + E+ +GQ T + G+ G V F +A+
Sbjct: 1412 TVLDENDNSPRFDFTSDSAV--SIPED---CPVGQRVATVKAWDPDAGSNGQVVFSLASG 1466
Query: 724 QDV-TDDIAIAED--GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDE 780
+I D G +F +PLDRE+ D Y + V+A ++G + + + I D
Sbjct: 1467 NIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVAS-DRGTPPRKKDHILQVTILDI 1525
Query: 781 NDNPPVFEHAT-YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM-FD 838
NDNPPV E Y + EN GT + ++ATD D G N++ Y + K+M F
Sbjct: 1526 NDNPPVIESPFGYNVSVNENVGGGTAVVQ---VRATDRDIGINSVLSYYITEGNKDMAFR 1582
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQI 896
+D +G + DRE++ Y L D G LS+ + + I DENDN P F Q
Sbjct: 1583 MDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQ- 1641
Query: 897 EENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNAL 956
+ +V + T+ TI ALD+D+ GP + I G + N
Sbjct: 1642 -PHYEVLLDEGPDTLNTSLITI--------QALDLDE-GPNGTVTYAIVAGNIV---NTF 1688
Query: 957 DLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLN 1016
+D + G I +A L+ Y + + R+ ++ A P RL
Sbjct: 1689 RIDRHM-GVI--------------TAAKELD---YEISHGRYTLIVTATDQCPILSHRLT 1730
Query: 1017 ISALDGGNLND-NISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFG 1075
+ N+ND N +V F +D F V E Q RV + A D D G
Sbjct: 1731 STTTVLVNVNDINDNVPTFPRDYEG----------PFEVTEGQPGPRVWTFL-AHDRDSG 1779
Query: 1076 QNANLTYFIQPSDTDLPFEISPLTGVLSV--NGELDRETEDKYILTVVARDNGXXXXXXX 1133
N + Y I D F ISP+ GVL V + ELDRET Y LT+ ARD G
Sbjct: 1780 PNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRG-MPPLSS 1838
Query: 1134 XXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIG 1193
D+NDN P ++ +P+ TI EN+P+
Sbjct: 1839 TMLVGIRVLDINDNDP-------------------------VLLNLPM-NITISENSPVS 1872
Query: 1194 TTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPD---EVE 1250
+ VA V A+D D N + R+ + + T + +P+ +
Sbjct: 1873 SFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTIS 1932
Query: 1251 MSDKPV---FISRYYELEI----EENVNAPVELVSLNLTEHYENFK--MRYYILN----- 1296
+ D P R Y+L + +EN N P+ S E EN +LN
Sbjct: 1933 VKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILA 1992
Query: 1297 -ENDTDIRR--TFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAE 1353
+ D DI T+ + L+ + S V VI+ +R+ +S + ++ +AE
Sbjct: 1993 LDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVII--DREAFSPPILELLL-LAE 2049
Query: 1354 DVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQL 1404
D+ G+ +++ I D NDN P F+ L + P G+ V+Q+
Sbjct: 2050 DI--GLLNSTAHLLITILDDNDNRPTFSPAT--LTVHLLENCPPGFSVLQV 2096
Score = 135 bits (327), Expect = 1e-30
Identities = 215/803 (26%), Positives = 315/803 (39%), Gaps = 128/803 (15%)
Query: 403 WRRQPLETNAPLEKTT-YVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVF-- 459
W RQPL+ E T + D G T VN++V D NDN P F
Sbjct: 88 WLRQPLDRETKSEFTVEFSVSDHQGVITRK-----------VNIQVG--DVNDNAPTFHN 134
Query: 460 --VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNT 517
+ E N VGT I V A DPDLG G VLY Q S F I+
Sbjct: 135 QPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF-----FAIDSAR 189
Query: 518 GTVSVAESPILEGRHA--LFVEASDQP-ANPSERRYSLAVVTIEVTRGTKGNKPDIPDFM 574
G V+V E A L V A+DQ P +LA++ +V + P F+
Sbjct: 190 GIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV-------QDMDPIFI 242
Query: 575 GAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLH--GYEEGVPFAVEERSGVIT 630
PY + + GT+V I D + Y ++ G + FA++ SGV+T
Sbjct: 243 NLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNTNSI-FALDYISGVLT 301
Query: 631 VVDDLSRYNRPMYDFEAVALQENANLS---------IVTNATVHVVDVNDERGVLLKGAH 681
+ L R N P+Y + + L+ + T + V+D+ND +
Sbjct: 302 LNGLLDREN-PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEY 360
Query: 682 SPIIFHVKENSAGAAIG-QIFH-----TNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED 735
S I + + + Q+ +M +Y G + F+I+ + D
Sbjct: 361 SVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSHHFIIS-----PTSVQGKAD 415
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
I PLD E D Y + A N+ V G +V I + +ENDN P+F Y
Sbjct: 416 IRIRVAIPLDYETVDRYDFDLFA--NESVPDHVGYAKVKITLINENDNRPIFSQPLYNIS 473
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
+ EN +GT + + ATD D GT FGE V F D DR
Sbjct: 474 LYENVTVGTSVLT---VLATDNDAGT--------FGE------------VSYFFSDDPDR 510
Query: 856 EKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAG 915
+ L +DTG LI++I + ++ I+ + I R+ T G
Sbjct: 511 -----FSLD---KDTG-------LIMLIA-----RLDYELIQRFTLTIIARDGGGEETTG 550
Query: 916 FTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVY 975
I V N + + + EN P T +++L A D DS N QI Y
Sbjct: 551 RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITY------- 603
Query: 976 IPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE------FRLNISALDGGN--LND 1027
S +SA A YF I+ G+ +++ S P + E L + A+D GN LN
Sbjct: 604 ---SIVSASAFG--SYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNS 658
Query: 1028 NISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
+ V + V D ND+ P F K Y +V E + ++ATD D + I
Sbjct: 659 TVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL 718
Query: 1088 DTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG-XXXXXXXXXXXXXXXXDVND 1146
+ F I+ +G ++ LDRET+ +YIL V A D G D+ND
Sbjct: 719 EGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIND 778
Query: 1147 NSPKFY---AFDELLEWKHPEAD 1166
N P + + L+E P++D
Sbjct: 779 NHPTWKDAPYYINLVEMTPPDSD 801
Score = 118 bits (285), Expect = 1e-25
Identities = 134/498 (26%), Positives = 206/498 (41%), Gaps = 48/498 (9%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
Q V +TLLD NDN+P + + Y ++ + + V AVDPDLG+NG ++Y
Sbjct: 762 QKTGIATVNITLLDINDNHPTWKDAPYY-INLVEMTPPDSDVTTVVAVDPDLGENGTLVY 820
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVA------ESP---ILEGRHALFVEASDQPANPSER 548
+Q + + +N TG + E+P E + V +D P +
Sbjct: 821 SIQPPNKF-----YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTD-CGRPPLK 874
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDV 606
S A V + + N D P F P+ V + G S+ Q+ D E V
Sbjct: 875 ATSSATVFVNL---LDLNDND-PTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLV 930
Query: 607 SYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVH 665
SY + G + F + SGV+ +L R Y VA S + T+H
Sbjct: 931 SYRMPVGMPR-MDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIH 989
Query: 666 VVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTG-NVR---FLIA 721
V+DVNDE P +++V S + + F + N G N F+
Sbjct: 990 VLDVNDETPTFF-----PAVYNV---SVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG 1041
Query: 722 NQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVIS--GAGIYQVTIYIED 779
D + D + T LDRE Y M ++ + G + G V + + D
Sbjct: 1042 GNVDGKFSVGY-RDAVVRTVVGLDRETTAAY-MLILEAIDNGPVGKRHTGTATVFVTVLD 1099
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMY-TLFGEGKEMFD 838
NDN P+F ++YE + E+ G I +KATDADEG Y L G F
Sbjct: 1100 VNDNRPIFLQSSYEASVPEDIPEGHSILQ---LKATDADEGEFGRVWYRILHGNHGNNFR 1156
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVA--RDTGGLSSEAELIIMIGDENDNKPEFNQI 896
+ + G++ LDRE+ + L + A D G + S +I+ + D ND P F Q
Sbjct: 1157 IHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQ- 1215
Query: 897 EENSKVRIHRETKLNGTA 914
++ S++ + RET GT+
Sbjct: 1216 QQYSRLGL-RETAGIGTS 1232
Score = 107 bits (257), Expect = 3e-22
Identities = 125/441 (28%), Positives = 195/441 (44%), Gaps = 37/441 (8%)
Query: 443 VNVEVTLLDANDNNPVF-VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQR 501
+ V + ++D NDNNP+F PS Y+ ++ + VGT+I V A D D G ++ Y L
Sbjct: 2391 IPVYLEIVDINDNNPIFDQPS--YQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGD 2448
Query: 502 TSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPAN-PSERRYSLAVVTIE 558
S F INP TG + V S E + + L A D P + S RR + V I+
Sbjct: 2449 GE-----SKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQ 2503
Query: 559 VTRGTKGNKPDI--PDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGY 614
V +P P F + YE N GTSV + D E +++Y L
Sbjct: 2504 VL-DVNDCRPQFSKPQFSTSVYE-----NEPAGTSVITMMATDQDEGPNGELTYSLEGPG 2557
Query: 615 EEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTNATVHVVDVNDER 673
E F V+ SG++T L Y + + VA L T V V+DVND R
Sbjct: 2558 VEA--FHVDMDSGLVTTQRPLQSYEK--FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNR 2613
Query: 674 GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFL-IANQQDVTDDIAI 732
V ++ + I+ +E + + +++ T+ NG FL A +D I
Sbjct: 2614 PVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGL-NGAVRYSFLKTAGNRDWEFFIID 2672
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH--- 789
G I T + LDRE + VY + ++A + + + + +ED +DN P+F
Sbjct: 2673 PISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPK 2732
Query: 790 --ATYEGF-IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVV 846
Y+ + E+S GT + N+ A DADEG NA+ Y + +E + G +
Sbjct: 2733 GSPQYQLLTVPEHSPRGTLV--GNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCL 2790
Query: 847 KFIGDSLDREKKIMYKLSLVA 867
+ D LDRE++ ++ + A
Sbjct: 2791 LVLRD-LDREREAIFSFIVKA 2810
Score = 105 bits (252), Expect = 1e-21
Identities = 122/457 (26%), Positives = 197/457 (43%), Gaps = 29/457 (6%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLT 506
+ +LD ND P F P+ +Y S+ + + + D D+G N + Y + +
Sbjct: 988 IHVLDVNDETPTFFPA-VYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFI---TGGN 1043
Query: 507 ITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIEVTRGTK 564
+ F + V E + L +EA D P +R++
Sbjct: 1044 VDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDN--GPVGKRHTGTATVFVTVLDVN 1101
Query: 565 GNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQN--DVSYDLLHGYEEGVPFAV 622
N+P F+ + YE V ++ G S+ Q++ DA E V Y +LHG G F +
Sbjct: 1102 DNRPI---FLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHG-NHGNNFRI 1157
Query: 623 EERSGVITVVD---DLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKG 679
+G++ D R + + EA S V V+V D+NDE V +
Sbjct: 1158 HVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSV-RVIVYVEDINDEAPVFTQQ 1216
Query: 680 AHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTI 738
+S + ++E + G ++ + T+ S G+G G V + I + + +I G I
Sbjct: 1217 QYSRL--GLRETAGIGTSVIVVQATDRDS--GDG-GLVNYRILSGAEGKFEID-ESTGLI 1270
Query: 739 FTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIME 798
T LD E + Y M V A ++ G V I + +E D F +A+YE I+E
Sbjct: 1271 ITVNYLDYETKTSYMMNVSAT-DQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILE 1329
Query: 799 NSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKK 858
N +GTEI + ++ T YT + K +F +D TGV+ G +DREK
Sbjct: 1330 NLALGTEIVRVQAYSIDNLNQITYRFNAYT-STQAKALFKIDAITGVITVQG-LVDREKG 1387
Query: 859 IMYKLSLVARDTG-GLSSEAELIIMIGDENDNKPEFN 894
Y L++VA D G + S ++ I + DENDN P F+
Sbjct: 1388 DFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFD 1424
Score = 105 bits (251), Expect = 2e-21
Identities = 118/439 (26%), Positives = 185/439 (42%), Gaps = 33/439 (7%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
S V V LLD NDN+P F NL + + G I +V A+D D G NG+V Y
Sbjct: 877 SSATVFVNLLDLNDNDPTF--QNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSY-- 932
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTI 557
R F IN ++G V E + L V ASD +L + +
Sbjct: 933 -RMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVL 991
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYE 615
+V T P F A Y V +V V + ND ++SY + G
Sbjct: 992 DVNDET-------PTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNV 1044
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQEN-ANLSIVTNATVHV--VDVNDE 672
+G F+V R V+ V L R Y A+ ATV V +DVND
Sbjct: 1045 DG-KFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDN 1103
Query: 673 RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI 732
R + L+ ++ + ++ G +I Q+ T+ G V + I + +
Sbjct: 1104 RPIFLQSSYEASV--PEDIPEGHSILQLKATDADE---GEFGRVWYRILHGNHGNNFRIH 1158
Query: 733 AEDGTIFT-QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
+G + +PLDRE+ + + ++ +N + +V +Y+ED ND PVF
Sbjct: 1159 VSNGLLMRGPRPLDRERNSSH-VLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQ 1217
Query: 792 YEGF-IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIG 850
Y + E + IGT + +++ATD D G L Y + + F++DE+TG++ +
Sbjct: 1218 YSRLGLRETAGIGTSVI---VVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITV- 1273
Query: 851 DSLDREKKIMYKLSLVARD 869
+ LD E K Y +++ A D
Sbjct: 1274 NYLDYETKTSYMMNVSATD 1292
Score = 104 bits (249), Expect = 3e-21
Identities = 91/334 (27%), Positives = 155/334 (46%), Gaps = 24/334 (7%)
Query: 71 GAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSL 128
G G NQ + +V + + D+NDN P + D PY++ + E+TP + + + P +G +
Sbjct: 757 GVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENG 816
Query: 129 TIPLTVPRGLTIFK------DIRA----FDRDKPNTPNSDVHYSIV-SGNDDGHFALESS 177
T+ ++ + IR DR+ P+ +++ IV S D G L+++
Sbjct: 817 TLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKAT 876
Query: 178 HKPVLLLRKVLDYDAGDKEFQ-LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELI 236
+ + +LD + D FQ L +A + + AID D G+ + Y +
Sbjct: 877 SSATVFVN-LLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP 935
Query: 237 SGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
G R F ++S +G + ELD + Q L+V AS P K++ + + I +
Sbjct: 936 VGMPRMDFLINSSSGVVVTTTELDRERIAEYQ-----LRVVASDAGTPTKSSTSTLTIHV 990
Query: 297 LDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSI 354
LD+ND P F YN+S+ E++P F V+ + TD D G N E +Y + + G FS+
Sbjct: 991 LDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSV 1050
Query: 355 DPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
R VR LDRE ++ + + A + P
Sbjct: 1051 GYRDA--VVRTVVGLDRETTAAYMLILEAIDNGP 1082
Score = 104 bits (249), Expect = 3e-21
Identities = 106/424 (25%), Positives = 180/424 (42%), Gaps = 22/424 (5%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI--APIGPSLTI 130
G+ +S+ + V + + D+NDN P+ L+ P ++T+ E +P L A G + +
Sbjct: 1832 GMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARL 1891
Query: 131 PLTVPRG-------LTIFKDIRAFDR--DKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
+ G + I +R D+ P + S+ ++ A +
Sbjct: 1892 TFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1951
Query: 182 LLLRKVLDYDA--GDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGN 239
+ L D +Q +M + + PI A+D D + A + Y+L+ G
Sbjct: 1952 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GA 2010
Query: 240 DRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
LF ++S G + + + +D E L + A + L + A + I +LD
Sbjct: 2011 QSGLFDINSSTGVVTVRSGVIIDREA-FSPPILELLLLAEDIG--LLNSTAHLLITILDD 2067
Query: 300 NDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD-DPKGAFSIDPRS 358
NDN P F + ++EN P GFSVLQV ATD+D G NGE Y+++ + F I +
Sbjct: 2068 NDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVT 2127
Query: 359 GWLTVRNQTVLDREAHSSLRMKVYAKETNP-SVVGTFADSQRIAKWRRQPLETNAPLEKT 417
G + V N T+ DRE S R+ V A + + GT + I E P++
Sbjct: 2128 GVIRVGNATI-DREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTV 2186
Query: 418 TYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGT 477
+ + + GT NI D L + + + A D+ VP+ F++ N G+
Sbjct: 2187 SVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAV--NINTGS 2244
Query: 478 VIGK 481
V+ K
Sbjct: 2245 VMVK 2248
Score = 101 bits (242), Expect = 2e-20
Identities = 135/518 (26%), Positives = 204/518 (39%), Gaps = 65/518 (12%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN T TI EV +N + + ENI G T++ LNA DLD Y
Sbjct: 656 LNSTVPVTI-EVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSR----EYG 710
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG---N 1024
S +Y +LE F IN R G + L E SE+ L + A+DGG N
Sbjct: 711 QESIIY---------SLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHN 761
Query: 1025 LNDNI-SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYF 1083
I +V + + D+ND+ P +K Y N+ E + V A D D G+N L Y
Sbjct: 762 QKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS 821
Query: 1084 IQPSDTDLPFEISPLTG-VLSVNGELDRETEDKY------ILTVVARDNGX-XXXXXXXX 1135
IQP + + ++ TG + + + LDRE D + + V D G
Sbjct: 822 IQPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 879
Query: 1136 XXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTT 1195
D+NDN P F + E +S + ++ + + P+G
Sbjct: 880 TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMP 939
Query: 1196 VAKVFANDTDFIG------NGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEV 1249
N + + + + Y L R + G P+ SST+ L + V DV DE
Sbjct: 940 RMDFLINSSSGVVVTTTELDRERIAEYQL--RVVASDAGTPTKSSTSTLTIHVLDVNDET 997
Query: 1250 EMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV 1307
P F Y + + E+V +V LN T++ N ++ Y+I N + F
Sbjct: 998 -----PTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGN---VDGKFS 1049
Query: 1308 IDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVV 1367
+ R+ + V DRE Y +I+ A PV + T V
Sbjct: 1050 VGYRDAVVRTVVGLDRETTAAYMLILEAIDNG----------PVGKRHTGTAT-----VF 1094
Query: 1368 VRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQLK 1405
V + DVNDN P F + ++P P G+ ++QLK
Sbjct: 1095 VTVLDVNDNRPIFLQSS--YEASVPEDIPEGHSILQLK 1130
Score = 101 bits (241), Expect = 3e-20
Identities = 175/724 (24%), Positives = 284/724 (39%), Gaps = 83/724 (11%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGK-VKAVDPDLGQNGMV-LYDLQRTSN 504
+ ++D NDN P F S Y ++ A+VG + ++ VD D G N M +Y + S+
Sbjct: 343 ILVIDINDNAPEFNSSE-YSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSH 401
Query: 505 LTITSPFKINPNTGT-VSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRGT 563
I SP + + VA E + + P Y+ +T+
Sbjct: 402 HFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDN 461
Query: 564 KGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVPFA 621
+ P F Y + NV +GTSV + NDA +VSY + F+
Sbjct: 462 R------PIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR---FS 512
Query: 622 VEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAH 681
+++ +G+I ++ L + +A ++ ++V+DVND K A+
Sbjct: 513 LDKDTGLIMLIARLDYELIQRFTLTIIA-RDGGGEETTGRVRINVLDVNDNVPTFQKDAY 571
Query: 682 SPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTD--DIAIAED-GTI 738
+ ++EN ++ Q+ + + + I + DI++ E G I
Sbjct: 572 ---VGALRENEP--SVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVI 626
Query: 739 FTQKPLDREK--RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFI 796
+PLD E+ + +TV+A + G VTI + DENDNPP F Y +
Sbjct: 627 SVSRPLDYEQISNGLIYLTVMA-MDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSV 685
Query: 797 MENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE 856
+EN G + N + E +Y+L EG F ++ +G + LDRE
Sbjct: 686 VENIMAGATVLFLNATDLDRSREYGQESIIYSL--EGSTQFRINARSGEITTTS-LLDRE 742
Query: 857 KKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGF 916
K SE LI+ D + N K I T
Sbjct: 743 TK----------------SEYILIVRAVDGG--------VGHNQKTGI-------ATVNI 771
Query: 917 TIIEVKPKNKFALDVDQLGPLFL-IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVY 975
T++++ + D P ++ + E P + + + A+D D G NG + Y
Sbjct: 772 TLLDINDNHPTWKDA----PYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ---- 823
Query: 976 IPPSKL-SADALEVKRYFVINERHGHVIVARSLPPESEF--RLNISALDGGN--LNDNIS 1030
PP+K S ++ K I H + P E+E ++ +S D G L S
Sbjct: 824 -PPNKFYSLNSTTGK----IRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSS 878
Query: 1031 VRVFVK--DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
VFV D+ND+ P F+ + V E + +V A D D G N ++Y +
Sbjct: 879 ATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGM 938
Query: 1089 TDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
+ F I+ +GV+ ELDRE +Y L VVA D G DVND +
Sbjct: 939 PRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAG-TPTKSSTSTLTIHVLDVNDET 997
Query: 1149 PKFY 1152
P F+
Sbjct: 998 PTFF 1001
Score = 101 bits (241), Expect = 3e-20
Identities = 120/487 (24%), Positives = 199/487 (40%), Gaps = 44/487 (9%)
Query: 427 TKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVD 486
T T+ +L S V V + D NDN P F F + + + G + A D
Sbjct: 1717 TATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEV-TEGQPGPRVWTFLAHD 1775
Query: 487 PDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVE----ASDQP 542
D G NG V Y + L F I+P G + V + L+ F A D+
Sbjct: 1776 RDSGPNGQVEYSIMDGDPL---GEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRG 1832
Query: 543 ANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE 602
P + + +++ N D P + P + N + + V + +DA
Sbjct: 1833 MPPLSSTMLVGIRVLDI------NDND-PVLLNLPMNITISENSPVSSFVAHVLASDADS 1885
Query: 603 QND--VSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT 660
+ +++++ G E F + +G++TV L R P Y N I
Sbjct: 1886 GCNARLTFNITAGNRERA-FFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIAR 1944
Query: 661 N----ATVHVVDVNDERGVLLKGAHSPIIFHVKENS-AGAAI----GQIFHTNMSS-IYG 710
+ + D ND + K + V ENS AG + G I + IY
Sbjct: 1945 RDYDLLLIFLSDENDNHPLFTKSTYQA---EVMENSPAGTPLTVLNGPILALDADQDIYA 2001
Query: 711 NGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDRE--KRDVYRMTVIAEFNKGVISGA 768
T + + D+ + T+ + +DRE + + ++AE + G+++
Sbjct: 2002 VVTYQLLGAQSGLFDINSSTGVV---TVRSGVIIDREAFSPPILELLLLAE-DIGLLNST 2057
Query: 769 GIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYT 828
+TI D+NDN P F AT ++EN G + + ATD D G N +Y
Sbjct: 2058 AHLLITIL--DDNDNRPTFSPATLTVHLLENCPPGFSVLQ---VTATDEDSGLNGELVYR 2112
Query: 829 LFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDE 886
+ ++ F + TGV++ ++DRE++ Y+L++VA D G LS A + I+I D
Sbjct: 2113 IEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDI 2172
Query: 887 NDNKPEF 893
ND++PEF
Sbjct: 2173 NDSRPEF 2179
Score = 99.1 bits (236), Expect = 1e-19
Identities = 183/777 (23%), Positives = 305/777 (39%), Gaps = 88/777 (11%)
Query: 582 VGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRP 641
+ + +G+SV Q+ D ND + G E FAVE +GV+ + L R +
Sbjct: 42 ISEDTPVGSSVTQLLAQDM--DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKS 99
Query: 642 MYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIF 701
+ E ++ ++ + I + V DVND +S I V IF
Sbjct: 100 EFTVE-FSVSDHQGV-ITRKVNIQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIF 157
Query: 702 HTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEF 760
N + G+V + Q + AI + G + + LD E Y++TV A
Sbjct: 158 IVNATDPDLGAGGSVLYSF---QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATD 214
Query: 761 NKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEG 820
+ + + I I D D P+F + Y I E+S GT ++ II A D D+G
Sbjct: 215 QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR---IITAIDQDKG 271
Query: 821 TNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELI 880
YT+ V NT + +LD ++ L+ R+ L S ++
Sbjct: 272 RPRGIGYTIVS-------VAGNTNSIF----ALDYISGVLTLNGLLDRENP-LYSHGFIL 319
Query: 881 IMIGDE-NDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFL 939
+ G E ND+ R + + T +I++ N A + +
Sbjct: 320 TVKGTELNDD-------------RTPSDATVTTTFNILVIDI---NDNAPEFNSSEYSVA 363
Query: 940 IPENIPIGTTI-IKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERH 998
I E +G + + + +D D GLN EVY+ + ++ + V +
Sbjct: 364 ITELAQVGFALPLFIQVVDKDEGLNSMF------EVYLVGN--NSHHFIISPTSVQGKAD 415
Query: 999 GHVIVARSLPPESEFRLNISALDGGNLNDNIS---VRVFVKDVNDHFPVFKKTWYNFNVE 1055
+ VA L E+ R + ++ D++ V++ + + ND+ P+F + YN ++
Sbjct: 416 IRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLY 475
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E + V ATD D G ++YF SD F + TG++ + LD E +
Sbjct: 476 ENVTVGTSVLTVLATDNDAGTFGEVSYFF--SDDPDRFSLDKDTGLIMLIARLDYELIQR 533
Query: 1116 YILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY--AFDELLEWKHPEADEL----- 1168
+ LT++ARD G DVNDN P F A+ L P +L
Sbjct: 534 FTLTIIARDGG---GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRA 590
Query: 1169 -------SNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQR 1221
+N S++ + + + + G V V + D+ NGLI ++
Sbjct: 591 TDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISV-SRPLDYEQISNGLIYLTV--- 646
Query: 1222 KNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL 1281
+ G P L+ST + + V D E + P F Y + + EN+ A ++ LN
Sbjct: 647 -MAMDAGNPPLNSTVPVTIEVFD-----ENDNPPTFSKPAYFVSVVENIMAGATVLFLNA 700
Query: 1282 T--EHYENFKMRYYILN-ENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
T + + I + E T R I+ R+G + DRE K Y +IVRA
Sbjct: 701 TDLDRSREYGQESIIYSLEGSTQFR----INARSGEITTTSLLDRETKSEYILIVRA 753
Score = 97.1 bits (231), Expect = 4e-19
Identities = 117/419 (27%), Positives = 173/419 (41%), Gaps = 53/419 (12%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
E IP G +I ++ A+DLD GLNG + Y V +P + F+IN G V
Sbjct: 906 EGIPAGVSIYQVVAIDLDEGLNGLVSYRM--PVGMP-----------RMDFLINSSSGVV 952
Query: 1002 IVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ L E +E++L + A D G + ++ + V DVND P F YN +V E
Sbjct: 953 VTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSED 1012
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYI 1117
+ ++ TD D G NA L+YFI + D F + V+ LDRET Y+
Sbjct: 1013 VPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYM 1072
Query: 1118 LTVVARDNG-XXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESV 1176
L + A DNG DVNDN P F E PE D H S+
Sbjct: 1073 LILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIF--LQSSYEASVPE-DIPEGH---SI 1126
Query: 1177 MMIPVYKATIEENAPIGTTVAKVFAND--TDF-IGNGNGLILYS---LPQRKNQQ----- 1225
+ + KAT + G ++ + +F I NGL++ L + +N
Sbjct: 1127 LQL---KATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIV 1183
Query: 1226 ---NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYY-ELEIEENVNAPVELVSLNL 1281
N L + S+ ++V V D+ DE PVF + Y L + E ++ +
Sbjct: 1184 EAYNHDLGPMRSSVRVIVYVEDINDEA-----PVFTQQQYSRLGLRETAGIGTSVIVVQA 1238
Query: 1282 TEH--YENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
T+ + + Y IL + F ID G + V D E K +Y + V A Q
Sbjct: 1239 TDRDSGDGGLVNYRIL----SGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQ 1293
Score = 89.8 bits (213), Expect = 6e-17
Identities = 91/332 (27%), Positives = 145/332 (43%), Gaps = 24/332 (7%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF---IFLIAPIGPSLTIPLTVPRGLT 139
V + + DVNDN P F + PY V + E+ TG IF++ P L +V
Sbjct: 118 VNIQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQ 177
Query: 140 IFKDIRAFDRDKPN-TPNSDVHYSIVSGNDDGHFALESSH-KPVLLLRK--VLDYDAGDK 195
A D + T ++ Y A + +P+ L ++ D D
Sbjct: 178 PPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDM 237
Query: 196 EFQLVIMASGKRIHKEI---LFPEPIHAIDQDLGVGATLRYELIS--GNDRKLFSLDSVN 250
+ + + I++ I AIDQD G + Y ++S GN +F+LD ++
Sbjct: 238 DPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNTNSIFALDYIS 297
Query: 251 GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV----EIELLDLNDNLPEF 306
G L L LD E+ L ++ F+L V+ ++LN+ + A V I ++D+NDN PEF
Sbjct: 298 GVLTLNGLLD--RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEF 355
Query: 307 EVDFYNISIVENLPNGFSV-LQVMATDKDQGENGEF-TYQLDDPKGAFSIDPRS----GW 360
Y+++I E GF++ L + DKD+G N F Y + + F I P S
Sbjct: 356 NSSEYSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSHHFIISPTSVQGKAD 415
Query: 361 LTVRNQTVLDREAHSSLRMKVYAKETNPSVVG 392
+ +R LD E ++A E+ P VG
Sbjct: 416 IRIRVAIPLDYETVDRYDFDLFANESVPDHVG 447
Score = 87.0 bits (206), Expect = 5e-16
Identities = 134/517 (25%), Positives = 211/517 (40%), Gaps = 72/517 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPE+ P+G + + A D D+G NGQ+ V+ S A A E+ N+ G
Sbjct: 1433 IPEDCPVGQRVATVKAWDPDAGSNGQV-------VFSLASGNIAGAFEI---VTTNDSIG 1482
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFKKTW-YNFN 1053
V VAR L E + L + A D G D+I ++V + D+ND+ PV + + YN +
Sbjct: 1483 EVFVARPLDREELDHYILQVVASDRGTPPRKKDHI-LQVTILDINDNPPVIESPFGYNVS 1541
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVN-GELDRET 1112
V E + +V ATD D G N+ L+Y+I + D+ F + ++G ++ DRE
Sbjct: 1542 VNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRER 1601
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYA--FDELLEWKHPEADELSN 1170
+ Y L D G D NDN+P F ++ LL+ + P+ S
Sbjct: 1602 QSFYHLVATVEDEG-TPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLD-EGPDTLNTSL 1659
Query: 1171 HNFESVMMIPVYKATIEENAPIGTTV----------AKVFANDTDF-IGNGNGLILYSLP 1219
+++ + T+ G V A + D+ I +G ++ +
Sbjct: 1660 ITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVT-- 1717
Query: 1220 QRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSL 1279
+Q + L+ST ++V V D+ D V P F R YE E P V
Sbjct: 1718 -ATDQCPILSHRLTSTTTVLVNVNDINDNV-----PTF-PRDYEGPFEVTEGQPGPRVWT 1770
Query: 1280 NLTEHYE---NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSP--DREVKDTYEVIVR 1334
L + N ++ Y I+ D D FVI P G L + + DRE Y + +
Sbjct: 1771 FLAHDRDSGPNGQVEYSIM---DGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTIC 1827
Query: 1335 AERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTT 1394
A R +P P++ +L G +R+ D+NDN P N P+ I
Sbjct: 1828 AR----DRGMP----PLSSTMLVG---------IRVLDINDNDPVLL--NLPMNITISEN 1868
Query: 1395 AP---FGYQVMQLKGAIGHHPTASRTVRADTDELVFF 1428
+P F V+ G + + + A E FF
Sbjct: 1869 SPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFF 1905
Score = 86.2 bits (204), Expect = 8e-16
Identities = 62/205 (30%), Positives = 92/205 (44%), Gaps = 7/205 (3%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I A+D D G T+ Y +++GN F +D G + KELD + H Q
Sbjct: 1662 IQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQ 1721
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN-ISIVENLPNGFSVLQVMATDKDQG 336
L++ L T+ V + + D+NDN+P F D+ + E P G V +A D+D G
Sbjct: 1722 CPILSHRL-TSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP-GPRVWTFLAHDRDSG 1779
Query: 337 ENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETN-PSVVGT 393
NG+ Y + DP G F I P G L VR LDRE + + + A++ P + T
Sbjct: 1780 PNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSST 1839
Query: 394 FADSQRIAKWR-RQPLETNAPLEKT 417
R+ P+ N P+ T
Sbjct: 1840 MLVGIRVLDINDNDPVLLNLPMNIT 1864
Score = 81.4 bits (192), Expect = 2e-14
Identities = 113/492 (22%), Positives = 204/492 (41%), Gaps = 54/492 (10%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + +LD ND P F + S+ N GT + + A D D G NG + Y L+
Sbjct: 2498 VQVVIQVLDVNDCRPQFSKPQ-FSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGP 2556
Query: 503 SNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F ++ ++G V+ + +L V A+D P L V I+V
Sbjct: 2557 G----VEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVN-- 2610
Query: 563 TKGNKPDIPDFMGAPYE--FWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLH--GYEE 616
N+P F+ P + + + ++V ++ D E V Y L G +
Sbjct: 2611 --DNRPV---FVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRD 2665
Query: 617 GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV--DVNDERG 674
F ++ SG+I L R ++ +Y VA + T + V D++D
Sbjct: 2666 WEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEP 2725
Query: 675 VLL---KGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
+ + KG+ + V E+S G +G + + + G F+ A ++ +
Sbjct: 2726 LFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGA-VDADEGPNAIVYYFIAAGNEE--KNF 2782
Query: 731 AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKG------------VISGAGIYQVTIYIE 778
+ DG + + LDRE+ ++ V A N+ +++ + +V + +E
Sbjct: 2783 HLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLE 2842
Query: 779 DENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG--EGKEM 836
D ND PP F A Y + ++K+G+E+ + A DAD G N+L Y++ + +
Sbjct: 2843 DINDQPPRFTKAEYTAGVATDAKVGSELIQ---VLALDADIGNNSLVFYSILAIHYFRAL 2899
Query: 837 FDVDENTGVVKFIG--DSLDREKKIM-------YKLSLVARDTGGLSSEAEL-IIMIGDE 886
+ E+ G V +G D + R + + + +VARD G + A + I ++ D+
Sbjct: 2900 ANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDD 2959
Query: 887 NDNKPEFNQIEE 898
K N+I +
Sbjct: 2960 QRVKIVINEIPD 2971
Score = 80.6 bits (190), Expect = 4e-14
Identities = 47/148 (31%), Positives = 78/148 (52%), Gaps = 4/148 (2%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G A + Y L G + F+++ G +++ LD + + +
Sbjct: 2429 VTATDADSGNFALIEYSLGDGESK--FAINPTTGDIYVLSSLDREKKDHYILTALAKDNP 2486
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
+N + + +V I++LD+ND P+F ++ S+ EN P G SV+ +MATD+D+G
Sbjct: 2487 GDVASNRRENS-VQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGP 2545
Query: 338 NGEFTYQLDDP-KGAFSIDPRSGWLTVR 364
NGE TY L+ P AF +D SG +T +
Sbjct: 2546 NGELTYSLEGPGVEAFHVDMDSGLVTTQ 2573
Score = 80.2 bits (189), Expect = 5e-14
Identities = 128/492 (26%), Positives = 206/492 (41%), Gaps = 65/492 (13%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
E++P+GT I+ + A D DSG I Y E K F IN G +
Sbjct: 2418 EDVPVGTIILTVTATDADSGNFALIEYSLGDG-------------ESK--FAINPTTGDI 2462
Query: 1002 IVARSLPPESEFRLNISALDGGNLND--------NISVRVFVKDVNDHFPVFKKTWYNFN 1053
V SL E + ++AL N D ++ V + V DVND P F K ++ +
Sbjct: 2463 YVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTS 2522
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETE 1113
V E + + + ATD D G N LTY ++ + F + +G+++ L ++
Sbjct: 2523 VYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA-FHVDMDSGLVTTQRPL--QSY 2579
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNF 1173
+K+ LTVVA D G DVNDN P F E L ++ +
Sbjct: 2580 EKFSLTVVATDGGEPPLWGTTMLLVEVI-DVNDNRPVFVRPPNGTILHIREEIPLRSNVY 2638
Query: 1174 ESVMMIPVYKATIEE--NAPIGTTVAKVFAN-DTDF--IGNGNGLILYSLPQRKNQQ--- 1225
E VY +E N + + K N D +F I +GLI + + Q
Sbjct: 2639 E------VYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY 2692
Query: 1226 -------NLGLPSLSSTAI-LMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELV 1277
+LG P T L V + D+ D + +P S Y+L + ++P +
Sbjct: 2693 SLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQL-LTVPEHSPRGTL 2751
Query: 1278 SLNLT-----EHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVI 1332
N+T + N + Y+I N+ + F + P +G L ++R DRE + + I
Sbjct: 2752 VGNVTGAVDADEGPNAIVYYFIAAGNE---EKNFHLQP-DGCLLVLRDLDREREAIFSFI 2807
Query: 1333 VRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIP 1392
V+A + S P P D++ +T +V+VV ++D+ND P+FT +
Sbjct: 2808 VKASSNR-SWTPPRGPSPTL-DLVADLTLQEVRVV--LEDINDQPPRFTKAE--YTAGVA 2861
Query: 1393 TTAPFGYQVMQL 1404
T A G +++Q+
Sbjct: 2862 TDAKVGSELIQV 2873
Score = 78.2 bits (184), Expect = 2e-13
Identities = 54/164 (32%), Positives = 84/164 (51%), Gaps = 12/164 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTFVL 274
+ A D D G + + L SGN F + + N G +F+ + LD + + + ++L
Sbjct: 1446 VKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDRE-----ELDHYIL 1500
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDK 333
QV AS P + +++ +LD+NDN P E F YN+S+ EN+ G +V+QV ATD+
Sbjct: 1501 QVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDR 1560
Query: 334 DQGENGEFTYQLDDPKG--AFSIDPRSGWLTVRNQTVLDREAHS 375
D G N +Y + + AF +D SG + R DRE S
Sbjct: 1561 DIGINSVLSYYITEGNKDMAFRMDRISGEIATR-PAPPDRERQS 1603
Score = 77.8 bits (183), Expect = 3e-13
Identities = 54/177 (30%), Positives = 86/177 (48%), Gaps = 9/177 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSL-DSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A+D D G+ + Y L+ L DS G + + +D + H L V
Sbjct: 2323 VAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLN-----FTV 2377
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+AS +P + A+ V +E++D+NDN P F+ Y ++ E++P G +L V ATD D G
Sbjct: 2378 RASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSG 2437
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
Y L D + F+I+P +G + V + LDRE + AK+ NP V +
Sbjct: 2438 NFALIEYSLGDGESKFAINPTTGDIYVLSS--LDREKKDHYILTALAKD-NPGDVAS 2491
Score = 76.2 bits (179), Expect = 9e-13
Identities = 81/326 (24%), Positives = 133/326 (40%), Gaps = 21/326 (6%)
Query: 77 ISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIA------PIGPSLTI 130
+S ++ + I DV D PIF++ PY + E +P G I P G TI
Sbjct: 221 LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI 280
Query: 131 PLTVPRGLTIF-----KDIRAFDR--DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLL 183
+IF + + D+ N S V G + S
Sbjct: 281 VSVAGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTT 340
Query: 184 LR-KVLDYDAGDKEFQLVIMASGKRIHKEILFPEP--IHAIDQDLGVGATLRYELISGND 240
V+D + EF + ++ F P I +D+D G+ + L+ N
Sbjct: 341 FNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNS 400
Query: 241 RK-LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
+ S SV G + + + ++ + + + A++ + P A+V+I L++
Sbjct: 401 HHFIISPTSVQGKADIRIRVAIPLDYET-VDRYDFDLFANE-SVPDHVGYAKVKITLINE 458
Query: 300 NDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSG 359
NDN P F YNIS+ EN+ G SVL V+ATD D G GE +Y D FS+D +G
Sbjct: 459 NDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTG 518
Query: 360 WLTVRNQTVLDREAHSSLRMKVYAKE 385
+ + + LD E + + A++
Sbjct: 519 LIMLIAR--LDYELIQRFTLTIIARD 542
Score = 73.7 bits (173), Expect = 5e-12
Identities = 87/331 (26%), Positives = 138/331 (41%), Gaps = 22/331 (6%)
Query: 73 GLNQISAYLSVTVYIE--DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLT- 129
G + A S TV++ D+NDN P F + P+ V E P G + + + L
Sbjct: 869 GRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNG 928
Query: 130 -----IPLTVPRGLTIFKDIRAFDRDKPNTPNSDV-HYSIVSGNDDGHFALESSHKPVLL 183
+P+ +PR + + Y + D +SS + +
Sbjct: 929 LVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTI 988
Query: 184 LRKVLDY-DAGDKEFQLVIMAS-GKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDR 241
VLD D F V S + + +E ++ D D+G+ A L Y + GN
Sbjct: 989 --HVLDVNDETPTFFPAVYNVSVSEDVPREFRVVW-LNCTDNDVGLNAELSYFITGGNVD 1045
Query: 242 KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLND 301
FS+ + + + LD E A +L+ + T A V + +LD+ND
Sbjct: 1046 GKFSVGYRDA--VVRTVVGLDRE-TTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVND 1102
Query: 302 NLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSG 359
N P F Y S+ E++P G S+LQ+ ATD D+GE G Y++ + F I +G
Sbjct: 1103 NRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNG 1162
Query: 360 WLTVRNQTVLDREAHSS--LRMKVYAKETNP 388
L +R LDRE +SS L ++ Y + P
Sbjct: 1163 -LLMRGPRPLDRERNSSHVLIVEAYNHDLGP 1192
Score = 70.9 bits (166), Expect = 3e-11
Identities = 122/490 (24%), Positives = 195/490 (39%), Gaps = 62/490 (12%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN+ GT ++++ A D D G+N + Y YI A + R + E
Sbjct: 1542 VNENVGGGTAVVQVRATDRDIGINSVLSY------YITEGNKDM-AFRMDR--ISGE--- 1589
Query: 1000 HVIVARSLPPESE----FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFN 1053
I R PP+ E + L + D G L+ V V + D ND+ P+F++ Y
Sbjct: 1590 --IATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVL 1647
Query: 1054 VEEAQYTRRV-LGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRE- 1111
++E T L + A D D G N +TY I + F I GV++ ELD E
Sbjct: 1648 LDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEI 1707
Query: 1112 TEDKYILTVVARDNG--XXXXXXXXXXXXXXXXDVNDNSPKF---YA--FDELLEWKHPE 1164
+ +Y L V A D D+NDN P F Y F+ P
Sbjct: 1708 SHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPR 1767
Query: 1165 ADELSNHNFESVMMIPVYKATIEENAPIG----TTVAKVFANDTDFIGNGNGLILYSLPQ 1220
H+ +S V + +I + P+G + V V D + + Y+L
Sbjct: 1768 VWTFLAHDRDSGPNGQV-EYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTI 1826
Query: 1221 RKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVS 1278
+ G+P LSST ++ + V D+ D + PV ++ + I EN V++ V V
Sbjct: 1827 CARDR--GMPPLSSTMLVGIRVLDIND-----NDPVLLNLPMNITISENSPVSSFVAHVL 1879
Query: 1279 LNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
+ + N ++ + I N R F I+ G + + R DRE Y++ +
Sbjct: 1880 ASDADSGCNARLTFNITAGNR---ERAFFINATTGIVTVNRPLDRERIPEYKLTISV--- 1933
Query: 1339 KYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFG 1398
K + E P + YD+ +++ + D NDN P FT + +P G
Sbjct: 1934 KDNPENPRI----------ARRDYDL-LLIFLSDENDNHPLFTKST--YQAEVMENSPAG 1980
Query: 1399 YQVMQLKGAI 1408
+ L G I
Sbjct: 1981 TPLTVLNGPI 1990
Score = 70.9 bits (166), Expect = 3e-11
Identities = 88/331 (26%), Positives = 134/331 (40%), Gaps = 23/331 (6%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIA---PIGPSLT 129
G +SA V V I D NDN P+F Y V +DE T + I + A GP+ T
Sbjct: 1615 GTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGT 1674
Query: 130 IPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR---- 185
+ + G I R T ++ Y I G + P+L R
Sbjct: 1675 VTYAIVAG-NIVNTFRIDRHMGVITAAKELDYEISHGRYT-LIVTATDQCPILSHRLTST 1732
Query: 186 KVLDYDAGDKEFQLVIMASGKRIHKEILFPEP------IHAIDQDLGVGATLRYELISGN 239
+ + D + E+ +P A D+D G + Y ++ G+
Sbjct: 1733 TTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGD 1792
Query: 240 DRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
F + V G L + K+++LD E N L + A P ++ V I +LD+
Sbjct: 1793 PLGEFVISPVEGVLRVRKDVELDRETIAFYN---LTICARDRGMPPLSSTMLVGIRVLDI 1849
Query: 300 NDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPR 357
NDN P NI+I EN P V V+A+D D G N T+ + + + AF I+
Sbjct: 1850 NDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINAT 1909
Query: 358 SGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
+G +TV LDRE ++ + K+ NP
Sbjct: 1910 TGIVTVNRP--LDRERIPEYKLTISVKD-NP 1937
Score = 67.3 bits (157), Expect = 4e-10
Identities = 54/173 (31%), Positives = 80/173 (46%), Gaps = 8/173 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G + Y ++ GN F + NG L + LD E N ++ VL V+
Sbjct: 1129 LKATDADEGEFGRVWYRILHGNHGNNFRIHVSNG-LLMRGPRPLDRERN---SSHVLIVE 1184
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN-ISIVENLPNGFSVLQVMATDKDQG 336
A + + RV + + D+ND P F Y+ + + E G SV+ V ATD+D G
Sbjct: 1185 AYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSG 1244
Query: 337 ENGEFTYQ-LDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
+ G Y+ L +G F ID +G + N LD E +S M V A + P
Sbjct: 1245 DGGLVNYRILSGAEGKFEIDESTGLIITVN--YLDYETKTSYMMNVSATDQAP 1295
Score = 63.7 bits (148), Expect = 5e-09
Identities = 59/211 (27%), Positives = 92/211 (43%), Gaps = 31/211 (14%)
Query: 929 LDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEF-------NSEV 974
LDV+ P+FL +PE+IP G +I++L A D D G G++ Y N +
Sbjct: 1098 LDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRI 1157
Query: 975 YIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVF 1034
++ L + R HV++ + D G + ++ V V+
Sbjct: 1158 HVSNGLLMRGPRPLDR----ERNSSHVLIVEAYNH-----------DLGPMRSSVRVIVY 1202
Query: 1035 VKDVNDHFPVFKKTWYN-FNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPF 1093
V+D+ND PVF + Y+ + E + V ATD D G + Y I S + F
Sbjct: 1203 VEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRIL-SGAEGKF 1261
Query: 1094 EISPLTGVLSVNGELDRETEDKYILTVVARD 1124
EI TG++ LD ET+ Y++ V A D
Sbjct: 1262 EIDESTGLIITVNYLDYETKTSYMMNVSATD 1292
Score = 62.9 bits (146), Expect = 9e-09
Identities = 53/170 (31%), Positives = 77/170 (45%), Gaps = 8/170 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGND-RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D+D + Y ++S + F + G + LD E + L V
Sbjct: 588 LRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ-ISNGLIYLTV 646
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A NP + V IE+ D NDN P F Y +S+VEN+ G +VL + ATD D+
Sbjct: 647 MAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRS 706
Query: 337 -ENGE--FTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
E G+ Y L+ F I+ RSG +T ++LDRE S + V A
Sbjct: 707 REYGQESIIYSLEG-STQFRINARSGEIT--TTSLLDRETKSEYILIVRA 753
Score = 62.9 bits (146), Expect = 9e-09
Identities = 46/175 (26%), Positives = 77/175 (44%), Gaps = 10/175 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D+D+G+ + L Y + GN F +D ++G + + D E + + L
Sbjct: 1555 VRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEI-ATRPAPPDRERQ---SFYHLVAT 1610
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN-GFSVLQVMATDKDQG 336
P +A V + ++D NDN P F+ Y + + E S++ + A D D+G
Sbjct: 1611 VEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEG 1670
Query: 337 ENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDRE-AHSSLRMKVYAKETNP 388
NG TY + + F ID G +T + LD E +H + V A + P
Sbjct: 1671 PNGTVTYAIVAGNIVNTFRIDRHMGVITAAKE--LDYEISHGRYTLIVTATDQCP 1723
Score = 61.7 bits (143), Expect = 2e-08
Identities = 59/203 (29%), Positives = 92/203 (45%), Gaps = 23/203 (11%)
Query: 935 GPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVI 994
G + I E IP+ + + ++ A D D GLNG +RY F L +F+I
Sbjct: 2622 GTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSF----------LKTAGNRDWEFFII 2671
Query: 995 NERHGHVIVARSLPPESE--FRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFKK-- 1047
+ G + A+ L ES+ + L + A D G ++V ++D++D+ P+F +
Sbjct: 2672 DPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPP 2731
Query: 1048 ----TWYNFNVEEAQYTRRVLGKV-DATDADFGQNANLTYFIQPSDTDLPFEISPLTGVL 1102
+ V E ++G V A DAD G NA + YFI + + F + P G L
Sbjct: 2732 KGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCL 2790
Query: 1103 SVNGELDRETEDKYILTVVARDN 1125
V +LDRE E + V A N
Sbjct: 2791 LVLRDLDREREAIFSFIVKASSN 2813
Score = 60.5 bits (140), Expect = 5e-08
Identities = 36/141 (25%), Positives = 67/141 (47%), Gaps = 5/141 (3%)
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
N F+++ GS+ ++ ++ + + V+ + + A++ + +LD
Sbjct: 2231 NQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLD 2290
Query: 299 LNDNLPEFE---VDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD--PKGAFS 353
+NDN P+F+ + +Y I+E G +++ V A D D+G NG TY L D P G
Sbjct: 2291 VNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQ 2350
Query: 354 IDPRSGWLTVRNQTVLDREAH 374
++ S + N+TV E H
Sbjct: 2351 LEDSSAGKVIANRTVDYEEVH 2371
Score = 58.4 bits (135), Expect = 2e-07
Identities = 41/126 (32%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D G + Y DR FSLD G + L LD + F L + A
Sbjct: 489 ATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYEL-----IQRFTLTIIAR 541
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
T RV I +LD+NDN+P F+ D Y ++ EN P+ ++++ ATD+D N
Sbjct: 542 DGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNN 599
Query: 340 EFTYQL 345
+ TY +
Sbjct: 600 QITYSI 605
Score = 58.4 bits (135), Expect = 2e-07
Identities = 114/498 (22%), Positives = 199/498 (39%), Gaps = 50/498 (10%)
Query: 83 VTVYIE--DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI--APIGPSLTIPLTVPRGL 138
+ VY+E D+NDN PIF Y V E P G A G I ++ G
Sbjct: 2391 IPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGE 2450
Query: 139 TIFK------DI---RAFDRDKPNTPNSDVHYSI--VSGNDDGHFALESSHKPVLLLRKV 187
+ F DI + DR+K + HY + ++ ++ G A V ++ +V
Sbjct: 2451 SKFAINPTTGDIYVLSSLDREKKD------HYILTALAKDNPGDVASNRRENSVQVVIQV 2504
Query: 188 LDYDAGDKEFQLVIMASGKRIHKEI-LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSL 246
LD + +F ++ ++ + A DQD G L Y L G + F +
Sbjct: 2505 LDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHV 2563
Query: 247 DSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF 306
D +G + ++ L F L V A+ P + +E++D+NDN P F
Sbjct: 2564 DMDSGLVTTQRPLQ-------SYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVF 2616
Query: 307 --EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKG-----AFSIDPRSG 359
+ + I E +P +V +V ATDKD+G NG Y G F IDP SG
Sbjct: 2617 VRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISG 2676
Query: 360 WLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGTFADSQRIAKWRRQPLETNAPLEKTTY 419
+ + LDRE+ + + + A + V ++A + ++ N PL +
Sbjct: 2677 LIQTAQR--LDRESQAVYSLILVASDLGQPVPYETMQPLQVA---LEDIDDNEPL----F 2727
Query: 420 VFPDKVGTKTENIEYYDEQLMSFVNVEVT-LLDANDNNPVFVPSNLYEFSMKSNAKVGTV 478
V P K + + + + + VT +DA++ V + + + N +
Sbjct: 2728 VRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD 2787
Query: 479 IGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEA 538
+ D D + + + ++ +SN + T P +P T+ + L+ + +
Sbjct: 2788 GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSP---TLDLVADLTLQEVRVVLEDI 2844
Query: 539 SDQPANPSERRYSLAVVT 556
+DQP ++ Y+ V T
Sbjct: 2845 NDQPPRFTKAEYTAGVAT 2862
Score = 54.0 bits (124), Expect = 4e-06
Identities = 43/156 (27%), Positives = 72/156 (46%), Gaps = 16/156 (10%)
Query: 236 ISGNDR-KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
+SG + + F+++ G ++L + LD + + + F ++ S + +V I
Sbjct: 69 VSGEEASRFFAVEPDTGVVWLRQPLDRETK-----SEFTVEFSVSDHQGVITR---KVNI 120
Query: 295 ELLDLNDNLPEFEVDFYNISIVE-----NLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
++ D+NDN P F Y++ I E N P G + V ATD D G G Y P
Sbjct: 121 QVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS 180
Query: 350 GAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
F+ID G +TV + LD E + ++ V A +
Sbjct: 181 QFFAIDSARGIVTVIRE--LDYETTQAYQLTVNATD 214
Score = 50.0 bits (114), Expect = 6e-05
Identities = 39/129 (30%), Positives = 62/129 (48%), Gaps = 10/129 (7%)
Query: 230 TLRYELISGNDRK-LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTA 288
T R+ + K LF +D++ G + ++ +D + + + + L V A P +
Sbjct: 1352 TYRFNAYTSTQAKALFKIDAITGVITVQGLVDRE-----KGDFYTLTVVADD-GGPKVDS 1405
Query: 289 QARVEIELLDLNDNLPEFEVDFYN-ISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-- 345
+V I +LD NDN P F+ + +SI E+ P G V V A D D G NG+ + L
Sbjct: 1406 TVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLAS 1465
Query: 346 DDPKGAFSI 354
+ GAF I
Sbjct: 1466 GNIAGAFEI 1474
Score = 49.2 bits (112), Expect = 1e-04
Identities = 79/323 (24%), Positives = 135/323 (41%), Gaps = 34/323 (10%)
Query: 81 LSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIA--PIGPS--LTIPLTVP- 135
+ V + + DVND P F + +V E P G + GP+ LT L P
Sbjct: 2498 VQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPG 2557
Query: 136 -RGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
+ D +P ++V+ D G L + +LL +V+D +
Sbjct: 2558 VEAFHVDMDSGLVTTQRPLQSYEKFSLTVVA-TDGGEPPLWGT---TMLLVEVIDVNDNR 2613
Query: 195 KEFQLVIMASGKRIHKEILFPE---PIHAIDQDLGVGATLRYELI--SGN-DRKLFSLDS 248
F + I +EI ++A D+D G+ +RY + +GN D + F +D
Sbjct: 2614 PVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDP 2673
Query: 249 VNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPL--KTAQARVEIELLDLNDNLPEF 306
++G + + LD +++ + L + AS L P+ +T Q +++ L D++DN P F
Sbjct: 2674 ISGLIQTAQRLDRESQ-----AVYSLILVASDLGQPVPYETMQP-LQVALEDIDDNEPLF 2727
Query: 307 ------EVDFYNISIVENLPNGFSVLQVM-ATDKDQGENGEFTYQL--DDPKGAFSIDPR 357
+ +++ E+ P G V V A D D+G N Y + + + F + P
Sbjct: 2728 VRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP- 2786
Query: 358 SGWLTVRNQTVLDREAHSSLRMK 380
G L V +REA S +K
Sbjct: 2787 DGCLLVLRDLDREREAIFSFIVK 2809
Score = 45.2 bits (102), Expect = 0.002
Identities = 35/137 (25%), Positives = 61/137 (44%), Gaps = 15/137 (10%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G A + Y + +GN+ K F L +G L + ++LD + E +F+++ ++
Sbjct: 2758 AVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIF---SFIVKASSN 2813
Query: 280 QLNNPLKTAQA-----------RVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQV 328
+ P + V + L D+ND P F Y + + G ++QV
Sbjct: 2814 RSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQV 2873
Query: 329 MATDKDQGENGEFTYQL 345
+A D D G N Y +
Sbjct: 2874 LALDADIGNNSLVFYSI 2890
Score = 44.8 bits (101), Expect = 0.002
Identities = 44/152 (28%), Positives = 72/152 (47%), Gaps = 28/152 (18%)
Query: 1233 SSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN--FKM 1290
+ TA + VTV DV D ++P+F+ YE + E++ ++ L T+ E ++
Sbjct: 1088 TGTATVFVTVLDVND-----NRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRV 1142
Query: 1291 RYYILNENDTDIRRTFVIDPRNGTLYLVRSP-DREVKDTYEVIVRAERQKYSRELPHMIY 1349
Y IL+ N + F I NG L P DRE ++ +IV A Y+ +L
Sbjct: 1143 WYRILHGNHGN---NFRIHVSNGLLMRGPRPLDRERNSSHVLIVEA----YNHDL----- 1190
Query: 1350 PVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
G + V+V+V ++D+ND +P FT
Sbjct: 1191 --------GPMRSSVRVIVYVEDINDEAPVFT 1214
Score = 40.7 bits (91), Expect = 0.039
Identities = 40/151 (26%), Positives = 67/151 (44%), Gaps = 12/151 (7%)
Query: 79 AYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS----LTIPLTV 134
A S+ + D+ VP P V ++++ + +F+ P G LT+P
Sbjct: 2690 AVYSLILVASDLGQPVPYETMQPLQVALEDID---DNEPLFVRPPKGSPQYQLLTVPEHS 2746
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
PRG + A D D+ PN+ V+Y I +GN++ +F L+ LL+ + LD + +
Sbjct: 2747 PRGTLVGNVTGAVDADEG--PNAIVYYFIAAGNEEKNFHLQPD--GCLLVLRDLDRER-E 2801
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAIDQDL 225
F ++ AS R P P + DL
Sbjct: 2802 AIFSFIVKASSNRSWTPPRGPSPTLDLVADL 2832
Score = 37.5 bits (83), Expect = 0.37
Identities = 19/51 (37%), Positives = 27/51 (52%), Gaps = 4/51 (7%)
Query: 1441 ATDSDIGINADIRYQILNEQAPR----FAIDPVSGTVRVVAALARDAGRVF 1487
ATD D G+N +RY L R F IDP+SG ++ L R++ V+
Sbjct: 2642 ATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY 2692
Score = 35.1 bits (77), Expect = 2.0
Identities = 21/54 (38%), Positives = 27/54 (50%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI 1084
VRV ++D+ND P F K Y V L +V A DAD G N+ + Y I
Sbjct: 2837 VRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSI 2890
Score = 33.5 bits (73), Expect = 6.0
Identities = 16/45 (35%), Positives = 25/45 (55%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTP 111
+V AG S+ ++T+++ DVND P F Y+V+V E P
Sbjct: 970 VVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVP 1014
>AL359183-3|CAI13426.1| 3359|Homo sapiens cadherin-like 23 protein.
Length = 3359
Score = 161 bits (392), Expect = 1e-38
Identities = 140/469 (29%), Positives = 215/469 (45%), Gaps = 25/469 (5%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L + +V VT++D NDN P+F + + + T + ++A+D D G NG V Y
Sbjct: 1619 LSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYA 1678
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAES---PILEGRHALFVEASDQPANPSERRYSLAVV 555
+ + I + F+I+ + G ++ A+ I GR+ L V A+DQ S R S V
Sbjct: 1679 IVAGN---IVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTV 1735
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGS-NVGIGTSVGQIRVNDAFEQNDVSYDLLHGY 614
+ V N P P P+E G + T + R D+ V Y ++ G
Sbjct: 1736 LVNVN-DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDR--DSGPNGQVEYSIMDGD 1792
Query: 615 EEGVPFAVEERSGVITVVDD--LSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVND 671
G F + GV+ V D L R Y+ A LS + V+D+ND
Sbjct: 1793 PLG-EFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDIND 1851
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
VLL + P+ + ENS ++ + H S + F I
Sbjct: 1852 NDPVLL---NLPMNITISENSPVSSF--VAHVLASDADSGCNARLTFNITAGNRERAFFI 1906
Query: 732 IAEDGTIFTQKPLDREKRDVYRMTVIAEFN--KGVISGAGIYQVTIYIEDENDNPPVFEH 789
A G + +PLDRE+ Y++T+ + N I+ + I++ DENDN P+F
Sbjct: 1907 NATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTK 1966
Query: 790 ATYEGFIMENSKIGTEIKMDN-IIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+TY+ +MENS GT + + N I A DAD+ A+ Y L G +FD++ +TGVV
Sbjct: 1967 STYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTV 2026
Query: 849 -IGDSLDRE--KKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFN 894
G +DRE + +L L+A D G L+S A L+I I D+NDN+P F+
Sbjct: 2027 RSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFS 2075
Score = 156 bits (378), Expect = 7e-37
Identities = 254/1016 (25%), Positives = 428/1016 (42%), Gaps = 138/1016 (13%)
Query: 439 LMSFVNVEVTLLDANDNNPVFV--PSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
L S + V + +LD NDN+PV + P N+ ++ N+ V + + V A D D G N +
Sbjct: 1836 LSSTMLVGIRVLDINDNDPVLLNLPMNI---TISENSPVSSFVAHVLASDADSGCNARLT 1892
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR---HALFVEASDQPANP--SERRYS 551
+++ + F IN TG V+V P+ R + L + D P NP + R Y
Sbjct: 1893 FNITAGNR---ERAFFINATTGIVTV-NRPLDRERIPEYKLTISVKDNPENPRIARRDYD 1948
Query: 552 LAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSV----GQIRVNDAFEQ--ND 605
L ++ + + P F + Y+ V N GT + G I DA +
Sbjct: 1949 LLLIFLS------DENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV 2002
Query: 606 VSYDLLHGYEEGVPFAVEERSGVITV----VDDLSRYNRPMYDFEAVALQENANLSIVTN 661
V+Y LL G + G+ F + +GV+TV + D ++ P+ + +A ++ L+ +
Sbjct: 2003 VTYQLL-GAQSGL-FDINSSTGVVTVRSGVIIDREAFSPPILELLLLA-EDIGLLNSTAH 2059
Query: 662 ATVHVVDVNDERGVLLKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLI 720
+ ++D ND R + + + H+ EN G ++ Q+ T+ S G V +
Sbjct: 2060 LLITILDDNDNRPTF---SPATLTVHLLENCPPGFSVLQVTATDEDS--GLNGELVYRIE 2114
Query: 721 ANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDE 780
A QD I + +DRE+++ YR+TV+A ++G + +G VTI I+D
Sbjct: 2115 AGAQD-RFLIHLVTGVIRVGNATIDREEQESYRLTVVAT-DRGTVPLSGTAIVTILIDDI 2172
Query: 781 NDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVD 840
ND+ P F + ++E+++ GT I NI T D N Y + G + D
Sbjct: 2173 NDSRPEFLNPIQTVSVLESAEPGTVIA--NI---TAIDHDLNPKLEYHIVG----IVAKD 2223
Query: 841 ENTGVVKFIGDSLD---REKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIE 897
+ +V D+ +M K S + R+ L + E+ + + D + PE +
Sbjct: 2224 DTDRLVPNQEDAFAVNINTGSVMVK-SPMNRE---LVATYEVTLSVIDNASDLPERSVSV 2279
Query: 898 ENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALD 957
N+K+ ++ + T F KP F + + I E GTT+I + A+D
Sbjct: 2280 PNAKLTVNVLDVNDNTPQF-----KP---FGITYY----MERILEGATPGTTLIAVAAVD 2327
Query: 958 LDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLN- 1016
D GLNG + Y +PP + + + G VI R++ E LN
Sbjct: 2328 PDKGLNGLVTYTLLD--LVPPGYVQLE----------DSSAGKVIANRTVDYEEVHWLNF 2375
Query: 1017 -ISALDGGNLNDNISVRVFVK--DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD 1073
+ A D G+ + V+++ D+ND+ P+F + Y V E ++ V ATDAD
Sbjct: 2376 TVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDAD 2435
Query: 1074 FGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG---XXXX 1130
G A + Y + D + F I+P TG + V LDRE +D YILT +A+DN
Sbjct: 2436 SGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNR 2493
Query: 1131 XXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENA 1190
DVND P+F P+ N + + AT ++
Sbjct: 2494 RENSVQVVIQVLDVNDCRPQF---------SKPQFSTSVYENEPAGTSVITMMATDQDEG 2544
Query: 1191 PIGTTVAKVFANDTD--FIGNGNGLILYSLPQRKNQQ--------NLGLPSLSSTAILMV 1240
P G + + + +GL+ P + ++ + G P L T +L+V
Sbjct: 2545 PNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLV 2604
Query: 1241 TVADVPDEVEMSDKPVFI--SRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILN 1296
V DV D ++PVF+ L I E + + + T+ E N +RY L
Sbjct: 2605 EVIDVND-----NRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLK 2659
Query: 1297 ENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVL 1356
F+IDP +G + + DRE + Y +I+ A + PV + +
Sbjct: 2660 TAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS---------DLGQPVPYETM 2710
Query: 1357 EGMTKYDVKVVVRIKDVNDNSPKFT----NGNRPLVTAIPTTAPFGYQVMQLKGAI 1408
+ + V ++D++DN P F + + +P +P G V + GA+
Sbjct: 2711 QPLQ-------VALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAV 2759
Score = 150 bits (364), Expect = 3e-35
Identities = 256/1011 (25%), Positives = 406/1011 (40%), Gaps = 135/1011 (13%)
Query: 432 IEYYDEQL---MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPD 488
+E Y+ L S V V V + D ND PVF ++ A +GT + V+A D D
Sbjct: 1183 VEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRD 1242
Query: 489 LGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPS 546
G G+V Y + + F+I+ +TG + E + + + V A+DQ A P
Sbjct: 1243 SGDGGLVNYRILSGAE----GKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQ-APPF 1297
Query: 547 ERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDV 606
+ + +T+ + F A YE + N+ +GT + +++ N +
Sbjct: 1298 NQGFCSVYITL------LNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQI 1351
Query: 607 SY--DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
+Y + + F ++ +GVITV + R Y VA + +
Sbjct: 1352 TYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYI 1411
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGT-GNVRFLIANQ 723
V+D ND + S + + E+ +GQ T + G+ G V F +A+
Sbjct: 1412 TVLDENDNSPRFDFTSDSAV--SIPED---CPVGQRVATVKAWDPDAGSNGQVVFSLASG 1466
Query: 724 QDV-TDDIAIAED--GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDE 780
+I D G +F +PLDRE+ D Y + V+A ++G + + + I D
Sbjct: 1467 NIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVAS-DRGTPPRKKDHILQVTILDI 1525
Query: 781 NDNPPVFEHAT-YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM-FD 838
NDNPPV E Y + EN GT + ++ATD D G N++ Y + K+M F
Sbjct: 1526 NDNPPVIESPFGYNVSVNENVGGGTAVVQ---VRATDRDIGINSVLSYYITEGNKDMAFR 1582
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQI 896
+D +G + DRE++ Y L D G LS+ + + I DENDN P F Q
Sbjct: 1583 MDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQ- 1641
Query: 897 EENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNAL 956
+ +V + T+ TI ALD+D+ GP + I G + N
Sbjct: 1642 -PHYEVLLDEGPDTLNTSLITI--------QALDLDE-GPNGTVTYAIVAGNIV---NTF 1688
Query: 957 DLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLN 1016
+D + G I +A L+ Y + + R+ ++ A P RL
Sbjct: 1689 RIDRHM-GVI--------------TAAKELD---YEISHGRYTLIVTATDQCPILSHRLT 1730
Query: 1017 ISALDGGNLND-NISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFG 1075
+ N+ND N +V F +D F V E Q RV + A D D G
Sbjct: 1731 STTTVLVNVNDINDNVPTFPRDYEG----------PFEVTEGQPGPRVWTFL-AHDRDSG 1779
Query: 1076 QNANLTYFIQPSDTDLPFEISPLTGVLSV--NGELDRETEDKYILTVVARDNGXXXXXXX 1133
N + Y I D F ISP+ GVL V + ELDRET Y LT+ ARD G
Sbjct: 1780 PNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRG-MPPLSS 1838
Query: 1134 XXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIG 1193
D+NDN P ++ +P+ TI EN+P+
Sbjct: 1839 TMLVGIRVLDINDNDP-------------------------VLLNLPM-NITISENSPVS 1872
Query: 1194 TTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPD---EVE 1250
+ VA V A+D D N + R+ + + T + +P+ +
Sbjct: 1873 SFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTIS 1932
Query: 1251 MSDKPV---FISRYYELEI----EENVNAPVELVSLNLTEHYENFK--MRYYILN----- 1296
+ D P R Y+L + +EN N P+ S E EN +LN
Sbjct: 1933 VKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILA 1992
Query: 1297 -ENDTDIRR--TFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAE 1353
+ D DI T+ + L+ + S V VI+ +R+ +S + ++ +AE
Sbjct: 1993 LDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVII--DREAFSPPILELLL-LAE 2049
Query: 1354 DVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQL 1404
D+ G+ +++ I D NDN P F+ L + P G+ V+Q+
Sbjct: 2050 DI--GLLNSTAHLLITILDDNDNRPTFSPAT--LTVHLLENCPPGFSVLQV 2096
Score = 135 bits (327), Expect = 1e-30
Identities = 215/803 (26%), Positives = 315/803 (39%), Gaps = 128/803 (15%)
Query: 403 WRRQPLETNAPLEKTT-YVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVF-- 459
W RQPL+ E T + D G T VN++V D NDN P F
Sbjct: 88 WLRQPLDRETKSEFTVEFSVSDHQGVITRK-----------VNIQVG--DVNDNAPTFHN 134
Query: 460 --VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNT 517
+ E N VGT I V A DPDLG G VLY Q S F I+
Sbjct: 135 QPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF-----FAIDSAR 189
Query: 518 GTVSVAESPILEGRHA--LFVEASDQP-ANPSERRYSLAVVTIEVTRGTKGNKPDIPDFM 574
G V+V E A L V A+DQ P +LA++ +V + P F+
Sbjct: 190 GIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV-------QDMDPIFI 242
Query: 575 GAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLH--GYEEGVPFAVEERSGVIT 630
PY + + GT+V I D + Y ++ G + FA++ SGV+T
Sbjct: 243 NLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNTNSI-FALDYISGVLT 301
Query: 631 VVDDLSRYNRPMYDFEAVALQENANLS---------IVTNATVHVVDVNDERGVLLKGAH 681
+ L R N P+Y + + L+ + T + V+D+ND +
Sbjct: 302 LNGLLDREN-PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEY 360
Query: 682 SPIIFHVKENSAGAAIG-QIFH-----TNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED 735
S I + + + Q+ +M +Y G + F+I+ + D
Sbjct: 361 SVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSHHFIIS-----PTSVQGKAD 415
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
I PLD E D Y + A N+ V G +V I + +ENDN P+F Y
Sbjct: 416 IRIRVAIPLDYETVDRYDFDLFA--NESVPDHVGYAKVKITLINENDNRPIFSQPLYNIS 473
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
+ EN +GT + + ATD D GT FGE V F D DR
Sbjct: 474 LYENVTVGTSVLT---VLATDNDAGT--------FGE------------VSYFFSDDPDR 510
Query: 856 EKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAG 915
+ L +DTG LI++I + ++ I+ + I R+ T G
Sbjct: 511 -----FSLD---KDTG-------LIMLIA-----RLDYELIQRFTLTIIARDGGGEETTG 550
Query: 916 FTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVY 975
I V N + + + EN P T +++L A D DS N QI Y
Sbjct: 551 RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITY------- 603
Query: 976 IPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE------FRLNISALDGGN--LND 1027
S +SA A YF I+ G+ +++ S P + E L + A+D GN LN
Sbjct: 604 ---SIVSASAFG--SYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNS 658
Query: 1028 NISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
+ V + V D ND+ P F K Y +V E + ++ATD D + I
Sbjct: 659 TVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL 718
Query: 1088 DTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG-XXXXXXXXXXXXXXXXDVND 1146
+ F I+ +G ++ LDRET+ +YIL V A D G D+ND
Sbjct: 719 EGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIND 778
Query: 1147 NSPKFY---AFDELLEWKHPEAD 1166
N P + + L+E P++D
Sbjct: 779 NHPTWKDAPYYINLVEMTPPDSD 801
Score = 118 bits (285), Expect = 1e-25
Identities = 134/498 (26%), Positives = 206/498 (41%), Gaps = 48/498 (9%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
Q V +TLLD NDN+P + + Y ++ + + V AVDPDLG+NG ++Y
Sbjct: 762 QKTGIATVNITLLDINDNHPTWKDAPYY-INLVEMTPPDSDVTTVVAVDPDLGENGTLVY 820
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVA------ESP---ILEGRHALFVEASDQPANPSER 548
+Q + + +N TG + E+P E + V +D P +
Sbjct: 821 SIQPPNKF-----YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTD-CGRPPLK 874
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDV 606
S A V + + N D P F P+ V + G S+ Q+ D E V
Sbjct: 875 ATSSATVFVNL---LDLNDND-PTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLV 930
Query: 607 SYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVH 665
SY + G + F + SGV+ +L R Y VA S + T+H
Sbjct: 931 SYRMPVGMPR-MDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIH 989
Query: 666 VVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTG-NVR---FLIA 721
V+DVNDE P +++V S + + F + N G N F+
Sbjct: 990 VLDVNDETPTFF-----PAVYNV---SVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG 1041
Query: 722 NQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVIS--GAGIYQVTIYIED 779
D + D + T LDRE Y M ++ + G + G V + + D
Sbjct: 1042 GNVDGKFSVGY-RDAVVRTVVGLDRETTAAY-MLILEAIDNGPVGKRHTGTATVFVTVLD 1099
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMY-TLFGEGKEMFD 838
NDN P+F ++YE + E+ G I +KATDADEG Y L G F
Sbjct: 1100 VNDNRPIFLQSSYEASVPEDIPEGHSILQ---LKATDADEGEFGRVWYRILHGNHGNNFR 1156
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVA--RDTGGLSSEAELIIMIGDENDNKPEFNQI 896
+ + G++ LDRE+ + L + A D G + S +I+ + D ND P F Q
Sbjct: 1157 IHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQ- 1215
Query: 897 EENSKVRIHRETKLNGTA 914
++ S++ + RET GT+
Sbjct: 1216 QQYSRLGL-RETAGIGTS 1232
Score = 107 bits (257), Expect = 3e-22
Identities = 125/441 (28%), Positives = 195/441 (44%), Gaps = 37/441 (8%)
Query: 443 VNVEVTLLDANDNNPVF-VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQR 501
+ V + ++D NDNNP+F PS Y+ ++ + VGT+I V A D D G ++ Y L
Sbjct: 2391 IPVYLEIVDINDNNPIFDQPS--YQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGD 2448
Query: 502 TSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPAN-PSERRYSLAVVTIE 558
S F INP TG + V S E + + L A D P + S RR + V I+
Sbjct: 2449 GE-----SKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQ 2503
Query: 559 VTRGTKGNKPDI--PDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGY 614
V +P P F + YE N GTSV + D E +++Y L
Sbjct: 2504 VL-DVNDCRPQFSKPQFSTSVYE-----NEPAGTSVITMMATDQDEGPNGELTYSLEGPG 2557
Query: 615 EEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTNATVHVVDVNDER 673
E F V+ SG++T L Y + + VA L T V V+DVND R
Sbjct: 2558 VEA--FHVDMDSGLVTTQRPLQSYEK--FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNR 2613
Query: 674 GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFL-IANQQDVTDDIAI 732
V ++ + I+ +E + + +++ T+ NG FL A +D I
Sbjct: 2614 PVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGL-NGAVRYSFLKTAGNRDWEFFIID 2672
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH--- 789
G I T + LDRE + VY + ++A + + + + +ED +DN P+F
Sbjct: 2673 PISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPK 2732
Query: 790 --ATYEGF-IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVV 846
Y+ + E+S GT + N+ A DADEG NA+ Y + +E + G +
Sbjct: 2733 GSPQYQLLTVPEHSPRGTLV--GNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCL 2790
Query: 847 KFIGDSLDREKKIMYKLSLVA 867
+ D LDRE++ ++ + A
Sbjct: 2791 LVLRD-LDREREAIFSFIVKA 2810
Score = 105 bits (252), Expect = 1e-21
Identities = 122/457 (26%), Positives = 197/457 (43%), Gaps = 29/457 (6%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLT 506
+ +LD ND P F P+ +Y S+ + + + D D+G N + Y + +
Sbjct: 988 IHVLDVNDETPTFFPA-VYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFI---TGGN 1043
Query: 507 ITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIEVTRGTK 564
+ F + V E + L +EA D P +R++
Sbjct: 1044 VDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDN--GPVGKRHTGTATVFVTVLDVN 1101
Query: 565 GNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQN--DVSYDLLHGYEEGVPFAV 622
N+P F+ + YE V ++ G S+ Q++ DA E V Y +LHG G F +
Sbjct: 1102 DNRPI---FLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHG-NHGNNFRI 1157
Query: 623 EERSGVITVVD---DLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKG 679
+G++ D R + + EA S V V+V D+NDE V +
Sbjct: 1158 HVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSV-RVIVYVEDINDEAPVFTQQ 1216
Query: 680 AHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTI 738
+S + ++E + G ++ + T+ S G+G G V + I + + +I G I
Sbjct: 1217 QYSRL--GLRETAGIGTSVIVVQATDRDS--GDG-GLVNYRILSGAEGKFEID-ESTGLI 1270
Query: 739 FTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIME 798
T LD E + Y M V A ++ G V I + +E D F +A+YE I+E
Sbjct: 1271 ITVNYLDYETKTSYMMNVSAT-DQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILE 1329
Query: 799 NSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKK 858
N +GTEI + ++ T YT + K +F +D TGV+ G +DREK
Sbjct: 1330 NLALGTEIVRVQAYSIDNLNQITYRFNAYT-STQAKALFKIDAITGVITVQG-LVDREKG 1387
Query: 859 IMYKLSLVARDTG-GLSSEAELIIMIGDENDNKPEFN 894
Y L++VA D G + S ++ I + DENDN P F+
Sbjct: 1388 DFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFD 1424
Score = 105 bits (251), Expect = 2e-21
Identities = 118/439 (26%), Positives = 185/439 (42%), Gaps = 33/439 (7%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
S V V LLD NDN+P F NL + + G I +V A+D D G NG+V Y
Sbjct: 877 SSATVFVNLLDLNDNDPTF--QNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSY-- 932
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTI 557
R F IN ++G V E + L V ASD +L + +
Sbjct: 933 -RMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVL 991
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYE 615
+V T P F A Y V +V V + ND ++SY + G
Sbjct: 992 DVNDET-------PTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNV 1044
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQEN-ANLSIVTNATVHV--VDVNDE 672
+G F+V R V+ V L R Y A+ ATV V +DVND
Sbjct: 1045 DG-KFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDN 1103
Query: 673 RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI 732
R + L+ ++ + ++ G +I Q+ T+ G V + I + +
Sbjct: 1104 RPIFLQSSYEASV--PEDIPEGHSILQLKATDADE---GEFGRVWYRILHGNHGNNFRIH 1158
Query: 733 AEDGTIFT-QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
+G + +PLDRE+ + + ++ +N + +V +Y+ED ND PVF
Sbjct: 1159 VSNGLLMRGPRPLDRERNSSH-VLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQ 1217
Query: 792 YEGF-IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIG 850
Y + E + IGT + +++ATD D G L Y + + F++DE+TG++ +
Sbjct: 1218 YSRLGLRETAGIGTSVI---VVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITV- 1273
Query: 851 DSLDREKKIMYKLSLVARD 869
+ LD E K Y +++ A D
Sbjct: 1274 NYLDYETKTSYMMNVSATD 1292
Score = 104 bits (249), Expect = 3e-21
Identities = 91/334 (27%), Positives = 155/334 (46%), Gaps = 24/334 (7%)
Query: 71 GAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSL 128
G G NQ + +V + + D+NDN P + D PY++ + E+TP + + + P +G +
Sbjct: 757 GVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENG 816
Query: 129 TIPLTVPRGLTIFK------DIRA----FDRDKPNTPNSDVHYSIV-SGNDDGHFALESS 177
T+ ++ + IR DR+ P+ +++ IV S D G L+++
Sbjct: 817 TLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKAT 876
Query: 178 HKPVLLLRKVLDYDAGDKEFQ-LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELI 236
+ + +LD + D FQ L +A + + AID D G+ + Y +
Sbjct: 877 SSATVFVN-LLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP 935
Query: 237 SGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
G R F ++S +G + ELD + Q L+V AS P K++ + + I +
Sbjct: 936 VGMPRMDFLINSSSGVVVTTTELDRERIAEYQ-----LRVVASDAGTPTKSSTSTLTIHV 990
Query: 297 LDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSI 354
LD+ND P F YN+S+ E++P F V+ + TD D G N E +Y + + G FS+
Sbjct: 991 LDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSV 1050
Query: 355 DPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
R VR LDRE ++ + + A + P
Sbjct: 1051 GYRDA--VVRTVVGLDRETTAAYMLILEAIDNGP 1082
Score = 104 bits (249), Expect = 3e-21
Identities = 106/424 (25%), Positives = 180/424 (42%), Gaps = 22/424 (5%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI--APIGPSLTI 130
G+ +S+ + V + + D+NDN P+ L+ P ++T+ E +P L A G + +
Sbjct: 1832 GMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARL 1891
Query: 131 PLTVPRG-------LTIFKDIRAFDR--DKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
+ G + I +R D+ P + S+ ++ A +
Sbjct: 1892 TFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1951
Query: 182 LLLRKVLDYDA--GDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGN 239
+ L D +Q +M + + PI A+D D + A + Y+L+ G
Sbjct: 1952 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GA 2010
Query: 240 DRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
LF ++S G + + + +D E L + A + L + A + I +LD
Sbjct: 2011 QSGLFDINSSTGVVTVRSGVIIDREA-FSPPILELLLLAEDIG--LLNSTAHLLITILDD 2067
Query: 300 NDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD-DPKGAFSIDPRS 358
NDN P F + ++EN P GFSVLQV ATD+D G NGE Y+++ + F I +
Sbjct: 2068 NDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVT 2127
Query: 359 GWLTVRNQTVLDREAHSSLRMKVYAKETNP-SVVGTFADSQRIAKWRRQPLETNAPLEKT 417
G + V N T+ DRE S R+ V A + + GT + I E P++
Sbjct: 2128 GVIRVGNATI-DREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTV 2186
Query: 418 TYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGT 477
+ + + GT NI D L + + + A D+ VP+ F++ N G+
Sbjct: 2187 SVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAV--NINTGS 2244
Query: 478 VIGK 481
V+ K
Sbjct: 2245 VMVK 2248
Score = 101 bits (242), Expect = 2e-20
Identities = 135/518 (26%), Positives = 204/518 (39%), Gaps = 65/518 (12%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN T TI EV +N + + ENI G T++ LNA DLD Y
Sbjct: 656 LNSTVPVTI-EVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSR----EYG 710
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG---N 1024
S +Y +LE F IN R G + L E SE+ L + A+DGG N
Sbjct: 711 QESIIY---------SLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHN 761
Query: 1025 LNDNI-SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYF 1083
I +V + + D+ND+ P +K Y N+ E + V A D D G+N L Y
Sbjct: 762 QKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS 821
Query: 1084 IQPSDTDLPFEISPLTG-VLSVNGELDRETEDKY------ILTVVARDNGX-XXXXXXXX 1135
IQP + + ++ TG + + + LDRE D + + V D G
Sbjct: 822 IQPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 879
Query: 1136 XXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTT 1195
D+NDN P F + E +S + ++ + + P+G
Sbjct: 880 TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMP 939
Query: 1196 VAKVFANDTDFIG------NGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEV 1249
N + + + + Y L R + G P+ SST+ L + V DV DE
Sbjct: 940 RMDFLINSSSGVVVTTTELDRERIAEYQL--RVVASDAGTPTKSSTSTLTIHVLDVNDET 997
Query: 1250 EMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV 1307
P F Y + + E+V +V LN T++ N ++ Y+I N + F
Sbjct: 998 -----PTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGN---VDGKFS 1049
Query: 1308 IDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVV 1367
+ R+ + V DRE Y +I+ A PV + T V
Sbjct: 1050 VGYRDAVVRTVVGLDRETTAAYMLILEAIDNG----------PVGKRHTGTAT-----VF 1094
Query: 1368 VRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQLK 1405
V + DVNDN P F + ++P P G+ ++QLK
Sbjct: 1095 VTVLDVNDNRPIFLQSS--YEASVPEDIPEGHSILQLK 1130
Score = 101 bits (241), Expect = 3e-20
Identities = 175/724 (24%), Positives = 284/724 (39%), Gaps = 83/724 (11%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGK-VKAVDPDLGQNGMV-LYDLQRTSN 504
+ ++D NDN P F S Y ++ A+VG + ++ VD D G N M +Y + S+
Sbjct: 343 ILVIDINDNAPEFNSSE-YSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSH 401
Query: 505 LTITSPFKINPNTGT-VSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRGT 563
I SP + + VA E + + P Y+ +T+
Sbjct: 402 HFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDN 461
Query: 564 KGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVPFA 621
+ P F Y + NV +GTSV + NDA +VSY + F+
Sbjct: 462 R------PIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR---FS 512
Query: 622 VEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAH 681
+++ +G+I ++ L + +A ++ ++V+DVND K A+
Sbjct: 513 LDKDTGLIMLIARLDYELIQRFTLTIIA-RDGGGEETTGRVRINVLDVNDNVPTFQKDAY 571
Query: 682 SPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTD--DIAIAED-GTI 738
+ ++EN ++ Q+ + + + I + DI++ E G I
Sbjct: 572 ---VGALRENEP--SVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVI 626
Query: 739 FTQKPLDREK--RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFI 796
+PLD E+ + +TV+A + G VTI + DENDNPP F Y +
Sbjct: 627 SVSRPLDYEQISNGLIYLTVMA-MDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSV 685
Query: 797 MENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE 856
+EN G + N + E +Y+L EG F ++ +G + LDRE
Sbjct: 686 VENIMAGATVLFLNATDLDRSREYGQESIIYSL--EGSTQFRINARSGEITTTS-LLDRE 742
Query: 857 KKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGF 916
K SE LI+ D + N K I T
Sbjct: 743 TK----------------SEYILIVRAVDGG--------VGHNQKTGI-------ATVNI 771
Query: 917 TIIEVKPKNKFALDVDQLGPLFL-IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVY 975
T++++ + D P ++ + E P + + + A+D D G NG + Y
Sbjct: 772 TLLDINDNHPTWKDA----PYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ---- 823
Query: 976 IPPSKL-SADALEVKRYFVINERHGHVIVARSLPPESEF--RLNISALDGGN--LNDNIS 1030
PP+K S ++ K I H + P E+E ++ +S D G L S
Sbjct: 824 -PPNKFYSLNSTTGK----IRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSS 878
Query: 1031 VRVFVK--DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
VFV D+ND+ P F+ + V E + +V A D D G N ++Y +
Sbjct: 879 ATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGM 938
Query: 1089 TDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
+ F I+ +GV+ ELDRE +Y L VVA D G DVND +
Sbjct: 939 PRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAG-TPTKSSTSTLTIHVLDVNDET 997
Query: 1149 PKFY 1152
P F+
Sbjct: 998 PTFF 1001
Score = 101 bits (241), Expect = 3e-20
Identities = 120/487 (24%), Positives = 199/487 (40%), Gaps = 44/487 (9%)
Query: 427 TKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVD 486
T T+ +L S V V + D NDN P F F + + + G + A D
Sbjct: 1717 TATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEV-TEGQPGPRVWTFLAHD 1775
Query: 487 PDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVE----ASDQP 542
D G NG V Y + L F I+P G + V + L+ F A D+
Sbjct: 1776 RDSGPNGQVEYSIMDGDPL---GEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRG 1832
Query: 543 ANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE 602
P + + +++ N D P + P + N + + V + +DA
Sbjct: 1833 MPPLSSTMLVGIRVLDI------NDND-PVLLNLPMNITISENSPVSSFVAHVLASDADS 1885
Query: 603 QND--VSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT 660
+ +++++ G E F + +G++TV L R P Y N I
Sbjct: 1886 GCNARLTFNITAGNRERA-FFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIAR 1944
Query: 661 N----ATVHVVDVNDERGVLLKGAHSPIIFHVKENS-AGAAI----GQIFHTNMSS-IYG 710
+ + D ND + K + V ENS AG + G I + IY
Sbjct: 1945 RDYDLLLIFLSDENDNHPLFTKSTYQA---EVMENSPAGTPLTVLNGPILALDADQDIYA 2001
Query: 711 NGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDRE--KRDVYRMTVIAEFNKGVISGA 768
T + + D+ + T+ + +DRE + + ++AE + G+++
Sbjct: 2002 VVTYQLLGAQSGLFDINSSTGVV---TVRSGVIIDREAFSPPILELLLLAE-DIGLLNST 2057
Query: 769 GIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYT 828
+TI D+NDN P F AT ++EN G + + ATD D G N +Y
Sbjct: 2058 AHLLITIL--DDNDNRPTFSPATLTVHLLENCPPGFSVLQ---VTATDEDSGLNGELVYR 2112
Query: 829 LFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDE 886
+ ++ F + TGV++ ++DRE++ Y+L++VA D G LS A + I+I D
Sbjct: 2113 IEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDI 2172
Query: 887 NDNKPEF 893
ND++PEF
Sbjct: 2173 NDSRPEF 2179
Score = 99.1 bits (236), Expect = 1e-19
Identities = 183/777 (23%), Positives = 305/777 (39%), Gaps = 88/777 (11%)
Query: 582 VGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRP 641
+ + +G+SV Q+ D ND + G E FAVE +GV+ + L R +
Sbjct: 42 ISEDTPVGSSVTQLLAQDM--DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKS 99
Query: 642 MYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIF 701
+ E ++ ++ + I + V DVND +S I V IF
Sbjct: 100 EFTVE-FSVSDHQGV-ITRKVNIQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIF 157
Query: 702 HTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEF 760
N + G+V + Q + AI + G + + LD E Y++TV A
Sbjct: 158 IVNATDPDLGAGGSVLYSF---QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATD 214
Query: 761 NKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEG 820
+ + + I I D D P+F + Y I E+S GT ++ II A D D+G
Sbjct: 215 QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR---IITAIDQDKG 271
Query: 821 TNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELI 880
YT+ V NT + +LD ++ L+ R+ L S ++
Sbjct: 272 RPRGIGYTIVS-------VAGNTNSIF----ALDYISGVLTLNGLLDRENP-LYSHGFIL 319
Query: 881 IMIGDE-NDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFL 939
+ G E ND+ R + + T +I++ N A + +
Sbjct: 320 TVKGTELNDD-------------RTPSDATVTTTFNILVIDI---NDNAPEFNSSEYSVA 363
Query: 940 IPENIPIGTTI-IKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERH 998
I E +G + + + +D D GLN EVY+ + ++ + V +
Sbjct: 364 ITELAQVGFALPLFIQVVDKDEGLNSMF------EVYLVGN--NSHHFIISPTSVQGKAD 415
Query: 999 GHVIVARSLPPESEFRLNISALDGGNLNDNIS---VRVFVKDVNDHFPVFKKTWYNFNVE 1055
+ VA L E+ R + ++ D++ V++ + + ND+ P+F + YN ++
Sbjct: 416 IRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLY 475
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E + V ATD D G ++YF SD F + TG++ + LD E +
Sbjct: 476 ENVTVGTSVLTVLATDNDAGTFGEVSYFF--SDDPDRFSLDKDTGLIMLIARLDYELIQR 533
Query: 1116 YILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY--AFDELLEWKHPEADEL----- 1168
+ LT++ARD G DVNDN P F A+ L P +L
Sbjct: 534 FTLTIIARDGG---GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRA 590
Query: 1169 -------SNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQR 1221
+N S++ + + + + G V V + D+ NGLI ++
Sbjct: 591 TDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISV-SRPLDYEQISNGLIYLTV--- 646
Query: 1222 KNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL 1281
+ G P L+ST + + V D E + P F Y + + EN+ A ++ LN
Sbjct: 647 -MAMDAGNPPLNSTVPVTIEVFD-----ENDNPPTFSKPAYFVSVVENIMAGATVLFLNA 700
Query: 1282 T--EHYENFKMRYYILN-ENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
T + + I + E T R I+ R+G + DRE K Y +IVRA
Sbjct: 701 TDLDRSREYGQESIIYSLEGSTQFR----INARSGEITTTSLLDRETKSEYILIVRA 753
Score = 97.1 bits (231), Expect = 4e-19
Identities = 117/419 (27%), Positives = 173/419 (41%), Gaps = 53/419 (12%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
E IP G +I ++ A+DLD GLNG + Y V +P + F+IN G V
Sbjct: 906 EGIPAGVSIYQVVAIDLDEGLNGLVSYRM--PVGMP-----------RMDFLINSSSGVV 952
Query: 1002 IVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ L E +E++L + A D G + ++ + V DVND P F YN +V E
Sbjct: 953 VTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSED 1012
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYI 1117
+ ++ TD D G NA L+YFI + D F + V+ LDRET Y+
Sbjct: 1013 VPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYM 1072
Query: 1118 LTVVARDNG-XXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESV 1176
L + A DNG DVNDN P F E PE D H S+
Sbjct: 1073 LILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIF--LQSSYEASVPE-DIPEGH---SI 1126
Query: 1177 MMIPVYKATIEENAPIGTTVAKVFAND--TDF-IGNGNGLILYS---LPQRKNQQ----- 1225
+ + KAT + G ++ + +F I NGL++ L + +N
Sbjct: 1127 LQL---KATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIV 1183
Query: 1226 ---NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYY-ELEIEENVNAPVELVSLNL 1281
N L + S+ ++V V D+ DE PVF + Y L + E ++ +
Sbjct: 1184 EAYNHDLGPMRSSVRVIVYVEDINDEA-----PVFTQQQYSRLGLRETAGIGTSVIVVQA 1238
Query: 1282 TEH--YENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
T+ + + Y IL + F ID G + V D E K +Y + V A Q
Sbjct: 1239 TDRDSGDGGLVNYRIL----SGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQ 1293
Score = 89.8 bits (213), Expect = 6e-17
Identities = 91/332 (27%), Positives = 145/332 (43%), Gaps = 24/332 (7%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF---IFLIAPIGPSLTIPLTVPRGLT 139
V + + DVNDN P F + PY V + E+ TG IF++ P L +V
Sbjct: 118 VNIQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQ 177
Query: 140 IFKDIRAFDRDKPN-TPNSDVHYSIVSGNDDGHFALESSH-KPVLLLRK--VLDYDAGDK 195
A D + T ++ Y A + +P+ L ++ D D
Sbjct: 178 PPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDM 237
Query: 196 EFQLVIMASGKRIHKEI---LFPEPIHAIDQDLGVGATLRYELIS--GNDRKLFSLDSVN 250
+ + + I++ I AIDQD G + Y ++S GN +F+LD ++
Sbjct: 238 DPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNTNSIFALDYIS 297
Query: 251 GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV----EIELLDLNDNLPEF 306
G L L LD E+ L ++ F+L V+ ++LN+ + A V I ++D+NDN PEF
Sbjct: 298 GVLTLNGLLD--RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEF 355
Query: 307 EVDFYNISIVENLPNGFSV-LQVMATDKDQGENGEF-TYQLDDPKGAFSIDPRS----GW 360
Y+++I E GF++ L + DKD+G N F Y + + F I P S
Sbjct: 356 NSSEYSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSHHFIISPTSVQGKAD 415
Query: 361 LTVRNQTVLDREAHSSLRMKVYAKETNPSVVG 392
+ +R LD E ++A E+ P VG
Sbjct: 416 IRIRVAIPLDYETVDRYDFDLFANESVPDHVG 447
Score = 87.0 bits (206), Expect = 5e-16
Identities = 134/517 (25%), Positives = 211/517 (40%), Gaps = 72/517 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPE+ P+G + + A D D+G NGQ+ V+ S A A E+ N+ G
Sbjct: 1433 IPEDCPVGQRVATVKAWDPDAGSNGQV-------VFSLASGNIAGAFEI---VTTNDSIG 1482
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFKKTW-YNFN 1053
V VAR L E + L + A D G D+I ++V + D+ND+ PV + + YN +
Sbjct: 1483 EVFVARPLDREELDHYILQVVASDRGTPPRKKDHI-LQVTILDINDNPPVIESPFGYNVS 1541
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVN-GELDRET 1112
V E + +V ATD D G N+ L+Y+I + D+ F + ++G ++ DRE
Sbjct: 1542 VNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRER 1601
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYA--FDELLEWKHPEADELSN 1170
+ Y L D G D NDN+P F ++ LL+ + P+ S
Sbjct: 1602 QSFYHLVATVEDEG-TPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLD-EGPDTLNTSL 1659
Query: 1171 HNFESVMMIPVYKATIEENAPIGTTV----------AKVFANDTDF-IGNGNGLILYSLP 1219
+++ + T+ G V A + D+ I +G ++ +
Sbjct: 1660 ITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVT-- 1717
Query: 1220 QRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSL 1279
+Q + L+ST ++V V D+ D V P F R YE E P V
Sbjct: 1718 -ATDQCPILSHRLTSTTTVLVNVNDINDNV-----PTF-PRDYEGPFEVTEGQPGPRVWT 1770
Query: 1280 NLTEHYE---NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSP--DREVKDTYEVIVR 1334
L + N ++ Y I+ D D FVI P G L + + DRE Y + +
Sbjct: 1771 FLAHDRDSGPNGQVEYSIM---DGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTIC 1827
Query: 1335 AERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTT 1394
A R +P P++ +L G +R+ D+NDN P N P+ I
Sbjct: 1828 AR----DRGMP----PLSSTMLVG---------IRVLDINDNDPVLL--NLPMNITISEN 1868
Query: 1395 AP---FGYQVMQLKGAIGHHPTASRTVRADTDELVFF 1428
+P F V+ G + + + A E FF
Sbjct: 1869 SPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFF 1905
Score = 86.2 bits (204), Expect = 8e-16
Identities = 62/205 (30%), Positives = 92/205 (44%), Gaps = 7/205 (3%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I A+D D G T+ Y +++GN F +D G + KELD + H Q
Sbjct: 1662 IQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQ 1721
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN-ISIVENLPNGFSVLQVMATDKDQG 336
L++ L T+ V + + D+NDN+P F D+ + E P G V +A D+D G
Sbjct: 1722 CPILSHRL-TSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP-GPRVWTFLAHDRDSG 1779
Query: 337 ENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETN-PSVVGT 393
NG+ Y + DP G F I P G L VR LDRE + + + A++ P + T
Sbjct: 1780 PNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSST 1839
Query: 394 FADSQRIAKWR-RQPLETNAPLEKT 417
R+ P+ N P+ T
Sbjct: 1840 MLVGIRVLDINDNDPVLLNLPMNIT 1864
Score = 81.4 bits (192), Expect = 2e-14
Identities = 113/492 (22%), Positives = 204/492 (41%), Gaps = 54/492 (10%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + +LD ND P F + S+ N GT + + A D D G NG + Y L+
Sbjct: 2498 VQVVIQVLDVNDCRPQFSKPQ-FSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGP 2556
Query: 503 SNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F ++ ++G V+ + +L V A+D P L V I+V
Sbjct: 2557 G----VEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVN-- 2610
Query: 563 TKGNKPDIPDFMGAPYE--FWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLH--GYEE 616
N+P F+ P + + + ++V ++ D E V Y L G +
Sbjct: 2611 --DNRPV---FVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRD 2665
Query: 617 GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV--DVNDERG 674
F ++ SG+I L R ++ +Y VA + T + V D++D
Sbjct: 2666 WEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEP 2725
Query: 675 VLL---KGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
+ + KG+ + V E+S G +G + + + G F+ A ++ +
Sbjct: 2726 LFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGA-VDADEGPNAIVYYFIAAGNEE--KNF 2782
Query: 731 AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKG------------VISGAGIYQVTIYIE 778
+ DG + + LDRE+ ++ V A N+ +++ + +V + +E
Sbjct: 2783 HLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLE 2842
Query: 779 DENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG--EGKEM 836
D ND PP F A Y + ++K+G+E+ + A DAD G N+L Y++ + +
Sbjct: 2843 DINDQPPRFTKAEYTAGVATDAKVGSELIQ---VLALDADIGNNSLVFYSILAIHYFRAL 2899
Query: 837 FDVDENTGVVKFIG--DSLDREKKIM-------YKLSLVARDTGGLSSEAEL-IIMIGDE 886
+ E+ G V +G D + R + + + +VARD G + A + I ++ D+
Sbjct: 2900 ANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDD 2959
Query: 887 NDNKPEFNQIEE 898
K N+I +
Sbjct: 2960 QRVKIVINEIPD 2971
Score = 80.6 bits (190), Expect = 4e-14
Identities = 47/148 (31%), Positives = 78/148 (52%), Gaps = 4/148 (2%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G A + Y L G + F+++ G +++ LD + + +
Sbjct: 2429 VTATDADSGNFALIEYSLGDGESK--FAINPTTGDIYVLSSLDREKKDHYILTALAKDNP 2486
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
+N + + +V I++LD+ND P+F ++ S+ EN P G SV+ +MATD+D+G
Sbjct: 2487 GDVASNRRENS-VQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGP 2545
Query: 338 NGEFTYQLDDP-KGAFSIDPRSGWLTVR 364
NGE TY L+ P AF +D SG +T +
Sbjct: 2546 NGELTYSLEGPGVEAFHVDMDSGLVTTQ 2573
Score = 80.2 bits (189), Expect = 5e-14
Identities = 128/492 (26%), Positives = 206/492 (41%), Gaps = 65/492 (13%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
E++P+GT I+ + A D DSG I Y E K F IN G +
Sbjct: 2418 EDVPVGTIILTVTATDADSGNFALIEYSLGDG-------------ESK--FAINPTTGDI 2462
Query: 1002 IVARSLPPESEFRLNISALDGGNLND--------NISVRVFVKDVNDHFPVFKKTWYNFN 1053
V SL E + ++AL N D ++ V + V DVND P F K ++ +
Sbjct: 2463 YVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTS 2522
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETE 1113
V E + + + ATD D G N LTY ++ + F + +G+++ L ++
Sbjct: 2523 VYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA-FHVDMDSGLVTTQRPL--QSY 2579
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNF 1173
+K+ LTVVA D G DVNDN P F E L ++ +
Sbjct: 2580 EKFSLTVVATDGGEPPLWGTTMLLVEVI-DVNDNRPVFVRPPNGTILHIREEIPLRSNVY 2638
Query: 1174 ESVMMIPVYKATIEE--NAPIGTTVAKVFAN-DTDF--IGNGNGLILYSLPQRKNQQ--- 1225
E VY +E N + + K N D +F I +GLI + + Q
Sbjct: 2639 E------VYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY 2692
Query: 1226 -------NLGLPSLSSTAI-LMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELV 1277
+LG P T L V + D+ D + +P S Y+L + ++P +
Sbjct: 2693 SLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQL-LTVPEHSPRGTL 2751
Query: 1278 SLNLT-----EHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVI 1332
N+T + N + Y+I N+ + F + P +G L ++R DRE + + I
Sbjct: 2752 VGNVTGAVDADEGPNAIVYYFIAAGNE---EKNFHLQP-DGCLLVLRDLDREREAIFSFI 2807
Query: 1333 VRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIP 1392
V+A + S P P D++ +T +V+VV ++D+ND P+FT +
Sbjct: 2808 VKASSNR-SWTPPRGPSPTL-DLVADLTLQEVRVV--LEDINDQPPRFTKAE--YTAGVA 2861
Query: 1393 TTAPFGYQVMQL 1404
T A G +++Q+
Sbjct: 2862 TDAKVGSELIQV 2873
Score = 78.2 bits (184), Expect = 2e-13
Identities = 54/164 (32%), Positives = 84/164 (51%), Gaps = 12/164 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTFVL 274
+ A D D G + + L SGN F + + N G +F+ + LD + + + ++L
Sbjct: 1446 VKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDRE-----ELDHYIL 1500
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDK 333
QV AS P + +++ +LD+NDN P E F YN+S+ EN+ G +V+QV ATD+
Sbjct: 1501 QVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDR 1560
Query: 334 DQGENGEFTYQLDDPKG--AFSIDPRSGWLTVRNQTVLDREAHS 375
D G N +Y + + AF +D SG + R DRE S
Sbjct: 1561 DIGINSVLSYYITEGNKDMAFRMDRISGEIATR-PAPPDRERQS 1603
Score = 77.8 bits (183), Expect = 3e-13
Identities = 54/177 (30%), Positives = 86/177 (48%), Gaps = 9/177 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSL-DSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A+D D G+ + Y L+ L DS G + + +D + H L V
Sbjct: 2323 VAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLN-----FTV 2377
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+AS +P + A+ V +E++D+NDN P F+ Y ++ E++P G +L V ATD D G
Sbjct: 2378 RASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSG 2437
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
Y L D + F+I+P +G + V + LDRE + AK+ NP V +
Sbjct: 2438 NFALIEYSLGDGESKFAINPTTGDIYVLSS--LDREKKDHYILTALAKD-NPGDVAS 2491
Score = 76.2 bits (179), Expect = 9e-13
Identities = 81/326 (24%), Positives = 133/326 (40%), Gaps = 21/326 (6%)
Query: 77 ISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIA------PIGPSLTI 130
+S ++ + I DV D PIF++ PY + E +P G I P G TI
Sbjct: 221 LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI 280
Query: 131 PLTVPRGLTIF-----KDIRAFDR--DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLL 183
+IF + + D+ N S V G + S
Sbjct: 281 VSVAGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTT 340
Query: 184 LR-KVLDYDAGDKEFQLVIMASGKRIHKEILFPEP--IHAIDQDLGVGATLRYELISGND 240
V+D + EF + ++ F P I +D+D G+ + L+ N
Sbjct: 341 FNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNS 400
Query: 241 RK-LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
+ S SV G + + + ++ + + + A++ + P A+V+I L++
Sbjct: 401 HHFIISPTSVQGKADIRIRVAIPLDYET-VDRYDFDLFANE-SVPDHVGYAKVKITLINE 458
Query: 300 NDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSG 359
NDN P F YNIS+ EN+ G SVL V+ATD D G GE +Y D FS+D +G
Sbjct: 459 NDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTG 518
Query: 360 WLTVRNQTVLDREAHSSLRMKVYAKE 385
+ + + LD E + + A++
Sbjct: 519 LIMLIAR--LDYELIQRFTLTIIARD 542
Score = 73.7 bits (173), Expect = 5e-12
Identities = 87/331 (26%), Positives = 138/331 (41%), Gaps = 22/331 (6%)
Query: 73 GLNQISAYLSVTVYIE--DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLT- 129
G + A S TV++ D+NDN P F + P+ V E P G + + + L
Sbjct: 869 GRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNG 928
Query: 130 -----IPLTVPRGLTIFKDIRAFDRDKPNTPNSDV-HYSIVSGNDDGHFALESSHKPVLL 183
+P+ +PR + + Y + D +SS + +
Sbjct: 929 LVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTI 988
Query: 184 LRKVLDY-DAGDKEFQLVIMAS-GKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDR 241
VLD D F V S + + +E ++ D D+G+ A L Y + GN
Sbjct: 989 --HVLDVNDETPTFFPAVYNVSVSEDVPREFRVVW-LNCTDNDVGLNAELSYFITGGNVD 1045
Query: 242 KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLND 301
FS+ + + + LD E A +L+ + T A V + +LD+ND
Sbjct: 1046 GKFSVGYRDA--VVRTVVGLDRE-TTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVND 1102
Query: 302 NLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSG 359
N P F Y S+ E++P G S+LQ+ ATD D+GE G Y++ + F I +G
Sbjct: 1103 NRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNG 1162
Query: 360 WLTVRNQTVLDREAHSS--LRMKVYAKETNP 388
L +R LDRE +SS L ++ Y + P
Sbjct: 1163 -LLMRGPRPLDRERNSSHVLIVEAYNHDLGP 1192
Score = 70.9 bits (166), Expect = 3e-11
Identities = 122/490 (24%), Positives = 195/490 (39%), Gaps = 62/490 (12%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN+ GT ++++ A D D G+N + Y YI A + R + E
Sbjct: 1542 VNENVGGGTAVVQVRATDRDIGINSVLSY------YITEGNKDM-AFRMDR--ISGE--- 1589
Query: 1000 HVIVARSLPPESE----FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFN 1053
I R PP+ E + L + D G L+ V V + D ND+ P+F++ Y
Sbjct: 1590 --IATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVL 1647
Query: 1054 VEEAQYTRRV-LGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRE- 1111
++E T L + A D D G N +TY I + F I GV++ ELD E
Sbjct: 1648 LDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEI 1707
Query: 1112 TEDKYILTVVARDNG--XXXXXXXXXXXXXXXXDVNDNSPKF---YA--FDELLEWKHPE 1164
+ +Y L V A D D+NDN P F Y F+ P
Sbjct: 1708 SHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPR 1767
Query: 1165 ADELSNHNFESVMMIPVYKATIEENAPIG----TTVAKVFANDTDFIGNGNGLILYSLPQ 1220
H+ +S V + +I + P+G + V V D + + Y+L
Sbjct: 1768 VWTFLAHDRDSGPNGQV-EYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTI 1826
Query: 1221 RKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVS 1278
+ G+P LSST ++ + V D+ D + PV ++ + I EN V++ V V
Sbjct: 1827 CARDR--GMPPLSSTMLVGIRVLDIND-----NDPVLLNLPMNITISENSPVSSFVAHVL 1879
Query: 1279 LNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
+ + N ++ + I N R F I+ G + + R DRE Y++ +
Sbjct: 1880 ASDADSGCNARLTFNITAGNR---ERAFFINATTGIVTVNRPLDRERIPEYKLTISV--- 1933
Query: 1339 KYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFG 1398
K + E P + YD+ +++ + D NDN P FT + +P G
Sbjct: 1934 KDNPENPRI----------ARRDYDL-LLIFLSDENDNHPLFTKST--YQAEVMENSPAG 1980
Query: 1399 YQVMQLKGAI 1408
+ L G I
Sbjct: 1981 TPLTVLNGPI 1990
Score = 70.9 bits (166), Expect = 3e-11
Identities = 88/331 (26%), Positives = 134/331 (40%), Gaps = 23/331 (6%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIA---PIGPSLT 129
G +SA V V I D NDN P+F Y V +DE T + I + A GP+ T
Sbjct: 1615 GTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGT 1674
Query: 130 IPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR---- 185
+ + G I R T ++ Y I G + P+L R
Sbjct: 1675 VTYAIVAG-NIVNTFRIDRHMGVITAAKELDYEISHGRYT-LIVTATDQCPILSHRLTST 1732
Query: 186 KVLDYDAGDKEFQLVIMASGKRIHKEILFPEP------IHAIDQDLGVGATLRYELISGN 239
+ + D + E+ +P A D+D G + Y ++ G+
Sbjct: 1733 TTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGD 1792
Query: 240 DRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
F + V G L + K+++LD E N L + A P ++ V I +LD+
Sbjct: 1793 PLGEFVISPVEGVLRVRKDVELDRETIAFYN---LTICARDRGMPPLSSTMLVGIRVLDI 1849
Query: 300 NDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPR 357
NDN P NI+I EN P V V+A+D D G N T+ + + + AF I+
Sbjct: 1850 NDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINAT 1909
Query: 358 SGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
+G +TV LDRE ++ + K+ NP
Sbjct: 1910 TGIVTVNRP--LDRERIPEYKLTISVKD-NP 1937
Score = 67.3 bits (157), Expect = 4e-10
Identities = 54/173 (31%), Positives = 80/173 (46%), Gaps = 8/173 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G + Y ++ GN F + NG L + LD E N ++ VL V+
Sbjct: 1129 LKATDADEGEFGRVWYRILHGNHGNNFRIHVSNG-LLMRGPRPLDRERN---SSHVLIVE 1184
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN-ISIVENLPNGFSVLQVMATDKDQG 336
A + + RV + + D+ND P F Y+ + + E G SV+ V ATD+D G
Sbjct: 1185 AYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSG 1244
Query: 337 ENGEFTYQ-LDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
+ G Y+ L +G F ID +G + N LD E +S M V A + P
Sbjct: 1245 DGGLVNYRILSGAEGKFEIDESTGLIITVN--YLDYETKTSYMMNVSATDQAP 1295
Score = 63.7 bits (148), Expect = 5e-09
Identities = 59/211 (27%), Positives = 92/211 (43%), Gaps = 31/211 (14%)
Query: 929 LDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEF-------NSEV 974
LDV+ P+FL +PE+IP G +I++L A D D G G++ Y N +
Sbjct: 1098 LDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRI 1157
Query: 975 YIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVF 1034
++ L + R HV++ + D G + ++ V V+
Sbjct: 1158 HVSNGLLMRGPRPLDR----ERNSSHVLIVEAYNH-----------DLGPMRSSVRVIVY 1202
Query: 1035 VKDVNDHFPVFKKTWYN-FNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPF 1093
V+D+ND PVF + Y+ + E + V ATD D G + Y I S + F
Sbjct: 1203 VEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRIL-SGAEGKF 1261
Query: 1094 EISPLTGVLSVNGELDRETEDKYILTVVARD 1124
EI TG++ LD ET+ Y++ V A D
Sbjct: 1262 EIDESTGLIITVNYLDYETKTSYMMNVSATD 1292
Score = 62.9 bits (146), Expect = 9e-09
Identities = 53/170 (31%), Positives = 77/170 (45%), Gaps = 8/170 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGND-RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D+D + Y ++S + F + G + LD E + L V
Sbjct: 588 LRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ-ISNGLIYLTV 646
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A NP + V IE+ D NDN P F Y +S+VEN+ G +VL + ATD D+
Sbjct: 647 MAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRS 706
Query: 337 -ENGE--FTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
E G+ Y L+ F I+ RSG +T ++LDRE S + V A
Sbjct: 707 REYGQESIIYSLEG-STQFRINARSGEIT--TTSLLDRETKSEYILIVRA 753
Score = 62.9 bits (146), Expect = 9e-09
Identities = 46/175 (26%), Positives = 77/175 (44%), Gaps = 10/175 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D+D+G+ + L Y + GN F +D ++G + + D E + + L
Sbjct: 1555 VRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEI-ATRPAPPDRERQ---SFYHLVAT 1610
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN-GFSVLQVMATDKDQG 336
P +A V + ++D NDN P F+ Y + + E S++ + A D D+G
Sbjct: 1611 VEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEG 1670
Query: 337 ENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDRE-AHSSLRMKVYAKETNP 388
NG TY + + F ID G +T + LD E +H + V A + P
Sbjct: 1671 PNGTVTYAIVAGNIVNTFRIDRHMGVITAAKE--LDYEISHGRYTLIVTATDQCP 1723
Score = 61.7 bits (143), Expect = 2e-08
Identities = 59/203 (29%), Positives = 92/203 (45%), Gaps = 23/203 (11%)
Query: 935 GPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVI 994
G + I E IP+ + + ++ A D D GLNG +RY F L +F+I
Sbjct: 2622 GTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSF----------LKTAGNRDWEFFII 2671
Query: 995 NERHGHVIVARSLPPESE--FRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFKK-- 1047
+ G + A+ L ES+ + L + A D G ++V ++D++D+ P+F +
Sbjct: 2672 DPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPP 2731
Query: 1048 ----TWYNFNVEEAQYTRRVLGKV-DATDADFGQNANLTYFIQPSDTDLPFEISPLTGVL 1102
+ V E ++G V A DAD G NA + YFI + + F + P G L
Sbjct: 2732 KGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCL 2790
Query: 1103 SVNGELDRETEDKYILTVVARDN 1125
V +LDRE E + V A N
Sbjct: 2791 LVLRDLDREREAIFSFIVKASSN 2813
Score = 60.5 bits (140), Expect = 5e-08
Identities = 36/141 (25%), Positives = 67/141 (47%), Gaps = 5/141 (3%)
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
N F+++ GS+ ++ ++ + + V+ + + A++ + +LD
Sbjct: 2231 NQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLD 2290
Query: 299 LNDNLPEFE---VDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD--PKGAFS 353
+NDN P+F+ + +Y I+E G +++ V A D D+G NG TY L D P G
Sbjct: 2291 VNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQ 2350
Query: 354 IDPRSGWLTVRNQTVLDREAH 374
++ S + N+TV E H
Sbjct: 2351 LEDSSAGKVIANRTVDYEEVH 2371
Score = 58.4 bits (135), Expect = 2e-07
Identities = 41/126 (32%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D G + Y DR FSLD G + L LD + F L + A
Sbjct: 489 ATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYEL-----IQRFTLTIIAR 541
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
T RV I +LD+NDN+P F+ D Y ++ EN P+ ++++ ATD+D N
Sbjct: 542 DGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNN 599
Query: 340 EFTYQL 345
+ TY +
Sbjct: 600 QITYSI 605
Score = 58.4 bits (135), Expect = 2e-07
Identities = 114/498 (22%), Positives = 199/498 (39%), Gaps = 50/498 (10%)
Query: 83 VTVYIE--DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI--APIGPSLTIPLTVPRGL 138
+ VY+E D+NDN PIF Y V E P G A G I ++ G
Sbjct: 2391 IPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGE 2450
Query: 139 TIFK------DI---RAFDRDKPNTPNSDVHYSI--VSGNDDGHFALESSHKPVLLLRKV 187
+ F DI + DR+K + HY + ++ ++ G A V ++ +V
Sbjct: 2451 SKFAINPTTGDIYVLSSLDREKKD------HYILTALAKDNPGDVASNRRENSVQVVIQV 2504
Query: 188 LDYDAGDKEFQLVIMASGKRIHKEI-LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSL 246
LD + +F ++ ++ + A DQD G L Y L G + F +
Sbjct: 2505 LDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHV 2563
Query: 247 DSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF 306
D +G + ++ L F L V A+ P + +E++D+NDN P F
Sbjct: 2564 DMDSGLVTTQRPLQ-------SYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVF 2616
Query: 307 --EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKG-----AFSIDPRSG 359
+ + I E +P +V +V ATDKD+G NG Y G F IDP SG
Sbjct: 2617 VRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISG 2676
Query: 360 WLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGTFADSQRIAKWRRQPLETNAPLEKTTY 419
+ + LDRE+ + + + A + V ++A + ++ N PL +
Sbjct: 2677 LIQTAQR--LDRESQAVYSLILVASDLGQPVPYETMQPLQVA---LEDIDDNEPL----F 2727
Query: 420 VFPDKVGTKTENIEYYDEQLMSFVNVEVT-LLDANDNNPVFVPSNLYEFSMKSNAKVGTV 478
V P K + + + + + VT +DA++ V + + + N +
Sbjct: 2728 VRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD 2787
Query: 479 IGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEA 538
+ D D + + + ++ +SN + T P +P T+ + L+ + +
Sbjct: 2788 GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSP---TLDLVADLTLQEVRVVLEDI 2844
Query: 539 SDQPANPSERRYSLAVVT 556
+DQP ++ Y+ V T
Sbjct: 2845 NDQPPRFTKAEYTAGVAT 2862
Score = 54.0 bits (124), Expect = 4e-06
Identities = 43/156 (27%), Positives = 72/156 (46%), Gaps = 16/156 (10%)
Query: 236 ISGNDR-KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
+SG + + F+++ G ++L + LD + + + F ++ S + +V I
Sbjct: 69 VSGEEASRFFAVEPDTGVVWLRQPLDRETK-----SEFTVEFSVSDHQGVITR---KVNI 120
Query: 295 ELLDLNDNLPEFEVDFYNISIVE-----NLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
++ D+NDN P F Y++ I E N P G + V ATD D G G Y P
Sbjct: 121 QVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS 180
Query: 350 GAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
F+ID G +TV + LD E + ++ V A +
Sbjct: 181 QFFAIDSARGIVTVIRE--LDYETTQAYQLTVNATD 214
Score = 50.0 bits (114), Expect = 6e-05
Identities = 39/129 (30%), Positives = 62/129 (48%), Gaps = 10/129 (7%)
Query: 230 TLRYELISGNDRK-LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTA 288
T R+ + K LF +D++ G + ++ +D + + + + L V A P +
Sbjct: 1352 TYRFNAYTSTQAKALFKIDAITGVITVQGLVDRE-----KGDFYTLTVVADD-GGPKVDS 1405
Query: 289 QARVEIELLDLNDNLPEFEVDFYN-ISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-- 345
+V I +LD NDN P F+ + +SI E+ P G V V A D D G NG+ + L
Sbjct: 1406 TVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLAS 1465
Query: 346 DDPKGAFSI 354
+ GAF I
Sbjct: 1466 GNIAGAFEI 1474
Score = 49.2 bits (112), Expect = 1e-04
Identities = 79/323 (24%), Positives = 135/323 (41%), Gaps = 34/323 (10%)
Query: 81 LSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIA--PIGPS--LTIPLTVP- 135
+ V + + DVND P F + +V E P G + GP+ LT L P
Sbjct: 2498 VQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPG 2557
Query: 136 -RGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
+ D +P ++V+ D G L + +LL +V+D +
Sbjct: 2558 VEAFHVDMDSGLVTTQRPLQSYEKFSLTVVA-TDGGEPPLWGT---TMLLVEVIDVNDNR 2613
Query: 195 KEFQLVIMASGKRIHKEILFPE---PIHAIDQDLGVGATLRYELI--SGN-DRKLFSLDS 248
F + I +EI ++A D+D G+ +RY + +GN D + F +D
Sbjct: 2614 PVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDP 2673
Query: 249 VNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPL--KTAQARVEIELLDLNDNLPEF 306
++G + + LD +++ + L + AS L P+ +T Q +++ L D++DN P F
Sbjct: 2674 ISGLIQTAQRLDRESQ-----AVYSLILVASDLGQPVPYETMQP-LQVALEDIDDNEPLF 2727
Query: 307 ------EVDFYNISIVENLPNGFSVLQVM-ATDKDQGENGEFTYQL--DDPKGAFSIDPR 357
+ +++ E+ P G V V A D D+G N Y + + + F + P
Sbjct: 2728 VRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP- 2786
Query: 358 SGWLTVRNQTVLDREAHSSLRMK 380
G L V +REA S +K
Sbjct: 2787 DGCLLVLRDLDREREAIFSFIVK 2809
Score = 45.2 bits (102), Expect = 0.002
Identities = 35/137 (25%), Positives = 61/137 (44%), Gaps = 15/137 (10%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G A + Y + +GN+ K F L +G L + ++LD + E +F+++ ++
Sbjct: 2758 AVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIF---SFIVKASSN 2813
Query: 280 QLNNPLKTAQA-----------RVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQV 328
+ P + V + L D+ND P F Y + + G ++QV
Sbjct: 2814 RSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQV 2873
Query: 329 MATDKDQGENGEFTYQL 345
+A D D G N Y +
Sbjct: 2874 LALDADIGNNSLVFYSI 2890
Score = 44.8 bits (101), Expect = 0.002
Identities = 44/152 (28%), Positives = 72/152 (47%), Gaps = 28/152 (18%)
Query: 1233 SSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN--FKM 1290
+ TA + VTV DV D ++P+F+ YE + E++ ++ L T+ E ++
Sbjct: 1088 TGTATVFVTVLDVND-----NRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRV 1142
Query: 1291 RYYILNENDTDIRRTFVIDPRNGTLYLVRSP-DREVKDTYEVIVRAERQKYSRELPHMIY 1349
Y IL+ N + F I NG L P DRE ++ +IV A Y+ +L
Sbjct: 1143 WYRILHGNHGN---NFRIHVSNGLLMRGPRPLDRERNSSHVLIVEA----YNHDL----- 1190
Query: 1350 PVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
G + V+V+V ++D+ND +P FT
Sbjct: 1191 --------GPMRSSVRVIVYVEDINDEAPVFT 1214
Score = 40.7 bits (91), Expect = 0.039
Identities = 40/151 (26%), Positives = 67/151 (44%), Gaps = 12/151 (7%)
Query: 79 AYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS----LTIPLTV 134
A S+ + D+ VP P V ++++ + +F+ P G LT+P
Sbjct: 2690 AVYSLILVASDLGQPVPYETMQPLQVALEDID---DNEPLFVRPPKGSPQYQLLTVPEHS 2746
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
PRG + A D D+ PN+ V+Y I +GN++ +F L+ LL+ + LD + +
Sbjct: 2747 PRGTLVGNVTGAVDADEG--PNAIVYYFIAAGNEEKNFHLQPD--GCLLVLRDLDRER-E 2801
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAIDQDL 225
F ++ AS R P P + DL
Sbjct: 2802 AIFSFIVKASSNRSWTPPRGPSPTLDLVADL 2832
Score = 37.5 bits (83), Expect = 0.37
Identities = 19/51 (37%), Positives = 27/51 (52%), Gaps = 4/51 (7%)
Query: 1441 ATDSDIGINADIRYQILNEQAPR----FAIDPVSGTVRVVAALARDAGRVF 1487
ATD D G+N +RY L R F IDP+SG ++ L R++ V+
Sbjct: 2642 ATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY 2692
Score = 35.1 bits (77), Expect = 2.0
Identities = 21/54 (38%), Positives = 27/54 (50%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI 1084
VRV ++D+ND P F K Y V L +V A DAD G N+ + Y I
Sbjct: 2837 VRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSI 2890
Score = 33.5 bits (73), Expect = 6.0
Identities = 16/45 (35%), Positives = 25/45 (55%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTP 111
+V AG S+ ++T+++ DVND P F Y+V+V E P
Sbjct: 970 VVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVP 1014
>AF312024-1|AAG48303.1| 3354|Homo sapiens cadherin related 23 protein.
Length = 3354
Score = 161 bits (392), Expect = 1e-38
Identities = 140/469 (29%), Positives = 215/469 (45%), Gaps = 25/469 (5%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L + +V VT++D NDN P+F + + + T + ++A+D D G NG V Y
Sbjct: 1614 LSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYA 1673
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAES---PILEGRHALFVEASDQPANPSERRYSLAVV 555
+ + I + F+I+ + G ++ A+ I GR+ L V A+DQ S R S V
Sbjct: 1674 IVAGN---IVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTV 1730
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGS-NVGIGTSVGQIRVNDAFEQNDVSYDLLHGY 614
+ V N P P P+E G + T + R D+ V Y ++ G
Sbjct: 1731 LVNVN-DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDR--DSGPNGQVEYSIMDGD 1787
Query: 615 EEGVPFAVEERSGVITVVDD--LSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVND 671
G F + GV+ V D L R Y+ A LS + V+D+ND
Sbjct: 1788 PLG-EFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDIND 1846
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
VLL + P+ + ENS ++ + H S + F I
Sbjct: 1847 NDPVLL---NLPMNITISENSPVSSF--VAHVLASDADSGCNARLTFNITAGNRERAFFI 1901
Query: 732 IAEDGTIFTQKPLDREKRDVYRMTVIAEFN--KGVISGAGIYQVTIYIEDENDNPPVFEH 789
A G + +PLDRE+ Y++T+ + N I+ + I++ DENDN P+F
Sbjct: 1902 NATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTK 1961
Query: 790 ATYEGFIMENSKIGTEIKMDN-IIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+TY+ +MENS GT + + N I A DAD+ A+ Y L G +FD++ +TGVV
Sbjct: 1962 STYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTV 2021
Query: 849 -IGDSLDRE--KKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFN 894
G +DRE + +L L+A D G L+S A L+I I D+NDN+P F+
Sbjct: 2022 RSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFS 2070
Score = 156 bits (378), Expect = 7e-37
Identities = 254/1016 (25%), Positives = 428/1016 (42%), Gaps = 138/1016 (13%)
Query: 439 LMSFVNVEVTLLDANDNNPVFV--PSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
L S + V + +LD NDN+PV + P N+ ++ N+ V + + V A D D G N +
Sbjct: 1831 LSSTMLVGIRVLDINDNDPVLLNLPMNI---TISENSPVSSFVAHVLASDADSGCNARLT 1887
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR---HALFVEASDQPANP--SERRYS 551
+++ + F IN TG V+V P+ R + L + D P NP + R Y
Sbjct: 1888 FNITAGNR---ERAFFINATTGIVTV-NRPLDRERIPEYKLTISVKDNPENPRIARRDYD 1943
Query: 552 LAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSV----GQIRVNDAFEQ--ND 605
L ++ + + P F + Y+ V N GT + G I DA +
Sbjct: 1944 LLLIFLS------DENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV 1997
Query: 606 VSYDLLHGYEEGVPFAVEERSGVITV----VDDLSRYNRPMYDFEAVALQENANLSIVTN 661
V+Y LL G + G+ F + +GV+TV + D ++ P+ + +A ++ L+ +
Sbjct: 1998 VTYQLL-GAQSGL-FDINSSTGVVTVRSGVIIDREAFSPPILELLLLA-EDIGLLNSTAH 2054
Query: 662 ATVHVVDVNDERGVLLKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLI 720
+ ++D ND R + + + H+ EN G ++ Q+ T+ S G V +
Sbjct: 2055 LLITILDDNDNRPTF---SPATLTVHLLENCPPGFSVLQVTATDEDS--GLNGELVYRIE 2109
Query: 721 ANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDE 780
A QD I + +DRE+++ YR+TV+A ++G + +G VTI I+D
Sbjct: 2110 AGAQD-RFLIHLVTGVIRVGNATIDREEQESYRLTVVAT-DRGTVPLSGTAIVTILIDDI 2167
Query: 781 NDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVD 840
ND+ P F + ++E+++ GT I NI T D N Y + G + D
Sbjct: 2168 NDSRPEFLNPIQTVSVLESAEPGTVIA--NI---TAIDHDLNPKLEYHIVG----IVAKD 2218
Query: 841 ENTGVVKFIGDSLD---REKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIE 897
+ +V D+ +M K S + R+ L + E+ + + D + PE +
Sbjct: 2219 DTDRLVPNQEDAFAVNINTGSVMVK-SPMNRE---LVATYEVTLSVIDNASDLPERSVSV 2274
Query: 898 ENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALD 957
N+K+ ++ + T F KP F + + I E GTT+I + A+D
Sbjct: 2275 PNAKLTVNVLDVNDNTPQF-----KP---FGITYY----MERILEGATPGTTLIAVAAVD 2322
Query: 958 LDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLN- 1016
D GLNG + Y +PP + + + G VI R++ E LN
Sbjct: 2323 PDKGLNGLVTYTLLD--LVPPGYVQLE----------DSSAGKVIANRTVDYEEVHWLNF 2370
Query: 1017 -ISALDGGNLNDNISVRVFVK--DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD 1073
+ A D G+ + V+++ D+ND+ P+F + Y V E ++ V ATDAD
Sbjct: 2371 TVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDAD 2430
Query: 1074 FGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG---XXXX 1130
G A + Y + D + F I+P TG + V LDRE +D YILT +A+DN
Sbjct: 2431 SGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNR 2488
Query: 1131 XXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENA 1190
DVND P+F P+ N + + AT ++
Sbjct: 2489 RENSVQVVIQVLDVNDCRPQF---------SKPQFSTSVYENEPAGTSVITMMATDQDEG 2539
Query: 1191 PIGTTVAKVFANDTD--FIGNGNGLILYSLPQRKNQQ--------NLGLPSLSSTAILMV 1240
P G + + + +GL+ P + ++ + G P L T +L+V
Sbjct: 2540 PNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLV 2599
Query: 1241 TVADVPDEVEMSDKPVFI--SRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILN 1296
V DV D ++PVF+ L I E + + + T+ E N +RY L
Sbjct: 2600 EVIDVND-----NRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLK 2654
Query: 1297 ENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVL 1356
F+IDP +G + + DRE + Y +I+ A + PV + +
Sbjct: 2655 TAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS---------DLGQPVPYETM 2705
Query: 1357 EGMTKYDVKVVVRIKDVNDNSPKFT----NGNRPLVTAIPTTAPFGYQVMQLKGAI 1408
+ + V ++D++DN P F + + +P +P G V + GA+
Sbjct: 2706 QPLQ-------VALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAV 2754
Score = 152 bits (369), Expect = 8e-36
Identities = 257/1011 (25%), Positives = 406/1011 (40%), Gaps = 135/1011 (13%)
Query: 432 IEYYDEQL---MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPD 488
+E Y+ L S V V V + D ND PVF ++ A +GT + V+A D D
Sbjct: 1178 VEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRD 1237
Query: 489 LGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPS 546
G G+V Y + + F+I+ +TG + E + + + V A+DQ A P
Sbjct: 1238 SGDGGLVNYRILSGAE----GKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQ-APPF 1292
Query: 547 ERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDV 606
+ + +T+ + F A YE + N+ +GT + +++ N +
Sbjct: 1293 NQGFCSVYITL------LNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQI 1346
Query: 607 SY--DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
+Y D + F ++ +GVITV + R Y VA + +
Sbjct: 1347 TYRFDAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYI 1406
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGT-GNVRFLIANQ 723
V+D ND + S + + E+ +GQ T + G+ G V F +A+
Sbjct: 1407 TVLDENDNSPRFDFTSDSAV--SIPED---CPVGQRVATVKAWDPDAGSNGQVVFSLASG 1461
Query: 724 QDV-TDDIAIAED--GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDE 780
+I D G +F +PLDRE+ D Y + V+A ++G + + + I D
Sbjct: 1462 NIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVAS-DRGTPPRKKDHILQVTILDI 1520
Query: 781 NDNPPVFEHAT-YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM-FD 838
NDNPPV E Y + EN GT + ++ATD D G N++ Y + K+M F
Sbjct: 1521 NDNPPVIESPFGYNVSVNENVGGGTAVVQ---VRATDRDIGINSVLSYYITEGNKDMTFR 1577
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQI 896
+D +G + DRE++ Y L D G LS+ + + I DENDN P F Q
Sbjct: 1578 MDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQ- 1636
Query: 897 EENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNAL 956
+ +V + T+ TI ALD+D+ GP + I G + N
Sbjct: 1637 -PHYEVLLDEGPDTLNTSLITI--------QALDLDE-GPNGTVTYAIVAGNIV---NTF 1683
Query: 957 DLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLN 1016
+D + G I +A L+ Y + + R+ ++ A P RL
Sbjct: 1684 RIDRHM-GVI--------------TAAKELD---YEISHGRYTLIVTATDQCPILSHRLT 1725
Query: 1017 ISALDGGNLND-NISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFG 1075
+ N+ND N +V F +D F V E Q RV + A D D G
Sbjct: 1726 STTTVLVNVNDINDNVPTFPRDYEG----------PFEVTEGQPGPRVWTFL-AHDRDSG 1774
Query: 1076 QNANLTYFIQPSDTDLPFEISPLTGVLSV--NGELDRETEDKYILTVVARDNGXXXXXXX 1133
N + Y I D F ISP+ GVL V + ELDRET Y LT+ ARD G
Sbjct: 1775 PNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRG-MPPLSS 1833
Query: 1134 XXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIG 1193
D+NDN P ++ +P+ TI EN+P+
Sbjct: 1834 TMLVGIRVLDINDNDP-------------------------VLLNLPM-NITISENSPVS 1867
Query: 1194 TTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPD---EVE 1250
+ VA V A+D D N + R+ + + T + +P+ +
Sbjct: 1868 SFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTIS 1927
Query: 1251 MSDKPV---FISRYYELEI----EENVNAPVELVSLNLTEHYENFK--MRYYILN----- 1296
+ D P R Y+L + +EN N P+ S E EN +LN
Sbjct: 1928 VKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILA 1987
Query: 1297 -ENDTDIRR--TFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAE 1353
+ D DI T+ + L+ + S V VI+ +R+ +S + ++ +AE
Sbjct: 1988 LDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVII--DREAFSPPILELLL-LAE 2044
Query: 1354 DVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQL 1404
D+ G+ +++ I D NDN P F+ L + P G+ V+Q+
Sbjct: 2045 DI--GLLNSTAHLLITILDDNDNRPTFSPAT--LTVHLLENCPPGFSVLQV 2091
Score = 143 bits (346), Expect = 5e-33
Identities = 215/799 (26%), Positives = 316/799 (39%), Gaps = 125/799 (15%)
Query: 403 WRRQPLETNAPLEKTT-YVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVP 461
W RQPL+ E T + D G T VN++V D NDN P F
Sbjct: 88 WLRQPLDRETKSEFTVEFSVSDHQGVITRK-----------VNIQVG--DVNDNAPTF-H 133
Query: 462 SNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVS 521
+ Y + N VGT I V A DPDLG G VLY Q S F I+ G V+
Sbjct: 134 NQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF-----FAIDSARGIVT 188
Query: 522 VAESPILEGRHA--LFVEASDQP-ANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPY 578
V E A L V A+DQ P +LA++ +V + P F+ PY
Sbjct: 189 VIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV-------QDMDPIFINLPY 241
Query: 579 EFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLS 636
+ + GT+V I D + Y ++ G + FA++ SGV+T+ L
Sbjct: 242 STNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSI-FALDYISGVLTLNGLLD 300
Query: 637 RYNRPMYDFEAVALQENANLS---------IVTNATVHVVDVNDERGVLLKGAHSPIIFH 687
R N P+Y + + L+ + T + V+D+ND +S I
Sbjct: 301 REN-PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITE 359
Query: 688 VKENSAGAAIG-QIFH-------TNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIF 739
+ + + Q+ +M +Y G + F+I+ + D I
Sbjct: 360 LAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIIS-----PTSVQGKADIRIR 414
Query: 740 TQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMEN 799
PLD E D Y + A N+ V G +V I + +ENDN P+F Y + EN
Sbjct: 415 VAIPLDYETVDRYDFDLFA--NESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYEN 472
Query: 800 SKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKI 859
+GT + + ATD D GT FGE V F D DR
Sbjct: 473 VTVGTSVLT---VLATDNDAGT--------FGE------------VSYFFSDDPDR---- 505
Query: 860 MYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTII 919
+ L +DTG LI++I + ++ I+ + I R+ T G I
Sbjct: 506 -FSLD---KDTG-------LIMLIA-----RLDYELIQRFTLTIIARDGGGEETTGRVRI 549
Query: 920 EVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPS 979
V N + + + EN P T +++L A D DS N QI Y S
Sbjct: 550 NVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITY----------S 599
Query: 980 KLSADALEVKRYFVINERHGHVIVARSLPPESE------FRLNISALDGGN--LNDNISV 1031
+SA A YF I+ G+ +++ S P + E L + A+D GN LN + V
Sbjct: 600 IVSASAFG--SYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPV 657
Query: 1032 RVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDL 1091
+ V D ND+ P F K Y +V E + ++ATD D + I +
Sbjct: 658 TIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST 717
Query: 1092 PFEISPLTGVLSVNGELDRETEDKYILTVVARDNG-XXXXXXXXXXXXXXXXDVNDNSPK 1150
F I+ +G ++ LDRET+ +YIL V A D G D+NDN P
Sbjct: 718 QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
Query: 1151 FY---AFDELLEWKHPEAD 1166
+ + L+E P++D
Sbjct: 778 WKDAPYYINLVEMTPPDSD 796
Score = 118 bits (285), Expect = 1e-25
Identities = 134/498 (26%), Positives = 206/498 (41%), Gaps = 48/498 (9%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
Q V +TLLD NDN+P + + Y ++ + + V AVDPDLG+NG ++Y
Sbjct: 757 QKTGIATVNITLLDINDNHPTWKDAPYY-INLVEMTPPDSDVTTVVAVDPDLGENGTLVY 815
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVA------ESP---ILEGRHALFVEASDQPANPSER 548
+Q + + +N TG + E+P E + V +D P +
Sbjct: 816 SIQPPNKF-----YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTD-CGRPPLK 869
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDV 606
S A V + + N D P F P+ V + G S+ Q+ D E V
Sbjct: 870 ATSSATVFVNL---LDLNDND-PTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLV 925
Query: 607 SYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVH 665
SY + G + F + SGV+ +L R Y VA S + T+H
Sbjct: 926 SYRMPVGMPR-MDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIH 984
Query: 666 VVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTG-NVR---FLIA 721
V+DVNDE P +++V S + + F + N G N F+
Sbjct: 985 VLDVNDETPTFF-----PAVYNV---SVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG 1036
Query: 722 NQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVIS--GAGIYQVTIYIED 779
D + D + T LDRE Y M ++ + G + G V + + D
Sbjct: 1037 GNVDGKFSVGY-RDAVVRTVVGLDRETTAAY-MLILEAIDNGPVGKRHTGTATVFVTVLD 1094
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMY-TLFGEGKEMFD 838
NDN P+F ++YE + E+ G I +KATDADEG Y L G F
Sbjct: 1095 VNDNRPIFLQSSYEASVPEDIPEGHSILQ---LKATDADEGEFGRVWYRILHGNHGNNFR 1151
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVA--RDTGGLSSEAELIIMIGDENDNKPEFNQI 896
+ + G++ LDRE+ + L + A D G + S +I+ + D ND P F Q
Sbjct: 1152 IHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQ- 1210
Query: 897 EENSKVRIHRETKLNGTA 914
++ S++ + RET GT+
Sbjct: 1211 QQYSRLGL-RETAGIGTS 1227
Score = 107 bits (257), Expect = 3e-22
Identities = 125/441 (28%), Positives = 195/441 (44%), Gaps = 37/441 (8%)
Query: 443 VNVEVTLLDANDNNPVF-VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQR 501
+ V + ++D NDNNP+F PS Y+ ++ + VGT+I V A D D G ++ Y L
Sbjct: 2386 IPVYLEIVDINDNNPIFDQPS--YQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGD 2443
Query: 502 TSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPAN-PSERRYSLAVVTIE 558
S F INP TG + V S E + + L A D P + S RR + V I+
Sbjct: 2444 GE-----SKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQ 2498
Query: 559 VTRGTKGNKPDI--PDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGY 614
V +P P F + YE N GTSV + D E +++Y L
Sbjct: 2499 VL-DVNDCRPQFSKPQFSTSVYE-----NEPAGTSVITMMATDQDEGPNGELTYSLEGPG 2552
Query: 615 EEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTNATVHVVDVNDER 673
E F V+ SG++T L Y + + VA L T V V+DVND R
Sbjct: 2553 VEA--FHVDMDSGLVTTQRPLQSYEK--FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNR 2608
Query: 674 GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFL-IANQQDVTDDIAI 732
V ++ + I+ +E + + +++ T+ NG FL A +D I
Sbjct: 2609 PVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGL-NGAVRYSFLKTAGNRDWEFFIID 2667
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH--- 789
G I T + LDRE + VY + ++A + + + + +ED +DN P+F
Sbjct: 2668 PISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPK 2727
Query: 790 --ATYEGF-IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVV 846
Y+ + E+S GT + N+ A DADEG NA+ Y + +E + G +
Sbjct: 2728 GSPQYQLLTVPEHSPRGTLV--GNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCL 2785
Query: 847 KFIGDSLDREKKIMYKLSLVA 867
+ D LDRE++ ++ + A
Sbjct: 2786 LVLRD-LDREREAIFSFIVKA 2805
Score = 105 bits (252), Expect = 1e-21
Identities = 122/457 (26%), Positives = 197/457 (43%), Gaps = 29/457 (6%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLT 506
+ +LD ND P F P+ +Y S+ + + + D D+G N + Y + +
Sbjct: 983 IHVLDVNDETPTFFPA-VYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFI---TGGN 1038
Query: 507 ITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIEVTRGTK 564
+ F + V E + L +EA D P +R++
Sbjct: 1039 VDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDN--GPVGKRHTGTATVFVTVLDVN 1096
Query: 565 GNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQN--DVSYDLLHGYEEGVPFAV 622
N+P F+ + YE V ++ G S+ Q++ DA E V Y +LHG G F +
Sbjct: 1097 DNRPI---FLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHG-NHGNNFRI 1152
Query: 623 EERSGVITVVD---DLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKG 679
+G++ D R + + EA S V V+V D+NDE V +
Sbjct: 1153 HVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSV-RVIVYVEDINDEAPVFTQQ 1211
Query: 680 AHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTI 738
+S + ++E + G ++ + T+ S G+G G V + I + + +I G I
Sbjct: 1212 QYSRL--GLRETAGIGTSVIVVQATDRDS--GDG-GLVNYRILSGAEGKFEID-ESTGLI 1265
Query: 739 FTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIME 798
T LD E + Y M V A ++ G V I + +E D F +A+YE I+E
Sbjct: 1266 ITVNYLDYETKTSYMMNVSAT-DQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILE 1324
Query: 799 NSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKK 858
N +GTEI + ++ T YT + K +F +D TGV+ G +DREK
Sbjct: 1325 NLALGTEIVRVQAYSIDNLNQITYRFDAYT-STQAKALFKIDAITGVITVQG-LVDREKG 1382
Query: 859 IMYKLSLVARDTG-GLSSEAELIIMIGDENDNKPEFN 894
Y L++VA D G + S ++ I + DENDN P F+
Sbjct: 1383 DFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFD 1419
Score = 105 bits (251), Expect = 2e-21
Identities = 118/439 (26%), Positives = 185/439 (42%), Gaps = 33/439 (7%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
S V V LLD NDN+P F NL + + G I +V A+D D G NG+V Y
Sbjct: 872 SSATVFVNLLDLNDNDPTF--QNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSY-- 927
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTI 557
R F IN ++G V E + L V ASD +L + +
Sbjct: 928 -RMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVL 986
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYE 615
+V T P F A Y V +V V + ND ++SY + G
Sbjct: 987 DVNDET-------PTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNV 1039
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQEN-ANLSIVTNATVHV--VDVNDE 672
+G F+V R V+ V L R Y A+ ATV V +DVND
Sbjct: 1040 DG-KFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDN 1098
Query: 673 RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI 732
R + L+ ++ + ++ G +I Q+ T+ G V + I + +
Sbjct: 1099 RPIFLQSSYEASV--PEDIPEGHSILQLKATDADE---GEFGRVWYRILHGNHGNNFRIH 1153
Query: 733 AEDGTIFT-QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
+G + +PLDRE+ + + ++ +N + +V +Y+ED ND PVF
Sbjct: 1154 VSNGLLMRGPRPLDRERNSSH-VLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQ 1212
Query: 792 YEGF-IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIG 850
Y + E + IGT + +++ATD D G L Y + + F++DE+TG++ +
Sbjct: 1213 YSRLGLRETAGIGTSVI---VVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITV- 1268
Query: 851 DSLDREKKIMYKLSLVARD 869
+ LD E K Y +++ A D
Sbjct: 1269 NYLDYETKTSYMMNVSATD 1287
Score = 104 bits (249), Expect = 3e-21
Identities = 91/334 (27%), Positives = 155/334 (46%), Gaps = 24/334 (7%)
Query: 71 GAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSL 128
G G NQ + +V + + D+NDN P + D PY++ + E+TP + + + P +G +
Sbjct: 752 GVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENG 811
Query: 129 TIPLTVPRGLTIFK------DIRA----FDRDKPNTPNSDVHYSIV-SGNDDGHFALESS 177
T+ ++ + IR DR+ P+ +++ IV S D G L+++
Sbjct: 812 TLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKAT 871
Query: 178 HKPVLLLRKVLDYDAGDKEFQ-LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELI 236
+ + +LD + D FQ L +A + + AID D G+ + Y +
Sbjct: 872 SSATVFVN-LLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP 930
Query: 237 SGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
G R F ++S +G + ELD + Q L+V AS P K++ + + I +
Sbjct: 931 VGMPRMDFLINSSSGVVVTTTELDRERIAEYQ-----LRVVASDAGTPTKSSTSTLTIHV 985
Query: 297 LDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSI 354
LD+ND P F YN+S+ E++P F V+ + TD D G N E +Y + + G FS+
Sbjct: 986 LDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSV 1045
Query: 355 DPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
R VR LDRE ++ + + A + P
Sbjct: 1046 GYRDA--VVRTVVGLDRETTAAYMLILEAIDNGP 1077
Score = 104 bits (249), Expect = 3e-21
Identities = 106/424 (25%), Positives = 180/424 (42%), Gaps = 22/424 (5%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI--APIGPSLTI 130
G+ +S+ + V + + D+NDN P+ L+ P ++T+ E +P L A G + +
Sbjct: 1827 GMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARL 1886
Query: 131 PLTVPRG-------LTIFKDIRAFDR--DKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
+ G + I +R D+ P + S+ ++ A +
Sbjct: 1887 TFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
Query: 182 LLLRKVLDYDA--GDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGN 239
+ L D +Q +M + + PI A+D D + A + Y+L+ G
Sbjct: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GA 2005
Query: 240 DRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
LF ++S G + + + +D E L + A + L + A + I +LD
Sbjct: 2006 QSGLFDINSSTGVVTVRSGVIIDREA-FSPPILELLLLAEDIG--LLNSTAHLLITILDD 2062
Query: 300 NDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD-DPKGAFSIDPRS 358
NDN P F + ++EN P GFSVLQV ATD+D G NGE Y+++ + F I +
Sbjct: 2063 NDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVT 2122
Query: 359 GWLTVRNQTVLDREAHSSLRMKVYAKETNP-SVVGTFADSQRIAKWRRQPLETNAPLEKT 417
G + V N T+ DRE S R+ V A + + GT + I E P++
Sbjct: 2123 GVIRVGNATI-DREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTV 2181
Query: 418 TYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGT 477
+ + + GT NI D L + + + A D+ VP+ F++ N G+
Sbjct: 2182 SVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAV--NINTGS 2239
Query: 478 VIGK 481
V+ K
Sbjct: 2240 VMVK 2243
Score = 101 bits (242), Expect = 2e-20
Identities = 135/518 (26%), Positives = 204/518 (39%), Gaps = 65/518 (12%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN T TI EV +N + + ENI G T++ LNA DLD Y
Sbjct: 651 LNSTVPVTI-EVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSR----EYG 705
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG---N 1024
S +Y +LE F IN R G + L E SE+ L + A+DGG N
Sbjct: 706 QESIIY---------SLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHN 756
Query: 1025 LNDNI-SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYF 1083
I +V + + D+ND+ P +K Y N+ E + V A D D G+N L Y
Sbjct: 757 QKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS 816
Query: 1084 IQPSDTDLPFEISPLTG-VLSVNGELDRETEDKY------ILTVVARDNGX-XXXXXXXX 1135
IQP + + ++ TG + + + LDRE D + + V D G
Sbjct: 817 IQPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 874
Query: 1136 XXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTT 1195
D+NDN P F + E +S + ++ + + P+G
Sbjct: 875 TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMP 934
Query: 1196 VAKVFANDTDFIG------NGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEV 1249
N + + + + Y L R + G P+ SST+ L + V DV DE
Sbjct: 935 RMDFLINSSSGVVVTTTELDRERIAEYQL--RVVASDAGTPTKSSTSTLTIHVLDVNDET 992
Query: 1250 EMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV 1307
P F Y + + E+V +V LN T++ N ++ Y+I N + F
Sbjct: 993 -----PTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGN---VDGKFS 1044
Query: 1308 IDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVV 1367
+ R+ + V DRE Y +I+ A PV + T V
Sbjct: 1045 VGYRDAVVRTVVGLDRETTAAYMLILEAIDNG----------PVGKRHTGTAT-----VF 1089
Query: 1368 VRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQLK 1405
V + DVNDN P F + ++P P G+ ++QLK
Sbjct: 1090 VTVLDVNDNRPIFLQSS--YEASVPEDIPEGHSILQLK 1125
Score = 101 bits (241), Expect = 3e-20
Identities = 120/487 (24%), Positives = 199/487 (40%), Gaps = 44/487 (9%)
Query: 427 TKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVD 486
T T+ +L S V V + D NDN P F F + + + G + A D
Sbjct: 1712 TATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEV-TEGQPGPRVWTFLAHD 1770
Query: 487 PDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVE----ASDQP 542
D G NG V Y + L F I+P G + V + L+ F A D+
Sbjct: 1771 RDSGPNGQVEYSIMDGDPL---GEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRG 1827
Query: 543 ANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE 602
P + + +++ N D P + P + N + + V + +DA
Sbjct: 1828 MPPLSSTMLVGIRVLDI------NDND-PVLLNLPMNITISENSPVSSFVAHVLASDADS 1880
Query: 603 QND--VSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT 660
+ +++++ G E F + +G++TV L R P Y N I
Sbjct: 1881 GCNARLTFNITAGNRERA-FFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIAR 1939
Query: 661 N----ATVHVVDVNDERGVLLKGAHSPIIFHVKENS-AGAAI----GQIFHTNMSS-IYG 710
+ + D ND + K + V ENS AG + G I + IY
Sbjct: 1940 RDYDLLLIFLSDENDNHPLFTKSTYQA---EVMENSPAGTPLTVLNGPILALDADQDIYA 1996
Query: 711 NGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDRE--KRDVYRMTVIAEFNKGVISGA 768
T + + D+ + T+ + +DRE + + ++AE + G+++
Sbjct: 1997 VVTYQLLGAQSGLFDINSSTGVV---TVRSGVIIDREAFSPPILELLLLAE-DIGLLNST 2052
Query: 769 GIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYT 828
+TI D+NDN P F AT ++EN G + + ATD D G N +Y
Sbjct: 2053 AHLLITIL--DDNDNRPTFSPATLTVHLLENCPPGFSVLQ---VTATDEDSGLNGELVYR 2107
Query: 829 LFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDE 886
+ ++ F + TGV++ ++DRE++ Y+L++VA D G LS A + I+I D
Sbjct: 2108 IEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDI 2167
Query: 887 NDNKPEF 893
ND++PEF
Sbjct: 2168 NDSRPEF 2174
Score = 98.7 bits (235), Expect = 1e-19
Identities = 176/726 (24%), Positives = 285/726 (39%), Gaps = 85/726 (11%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGK-VKAVDPD--LGQNGMV-LYDLQRT 502
+ ++D NDN P F S Y ++ A+VG + ++ VD D LG N M +Y +
Sbjct: 336 ILVIDINDNAPEFNSSE-YSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNN 394
Query: 503 SNLTITSPFKINPNTGT-VSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTR 561
S+ I SP + + VA E + + P Y+ +T+
Sbjct: 395 SHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINEN 454
Query: 562 GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVP 619
+ P F Y + NV +GTSV + NDA +VSY +
Sbjct: 455 DNR------PIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR--- 505
Query: 620 FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKG 679
F++++ +G+I ++ L + +A ++ ++V+DVND K
Sbjct: 506 FSLDKDTGLIMLIARLDYELIQRFTLTIIA-RDGGGEETTGRVRINVLDVNDNVPTFQKD 564
Query: 680 AHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTD--DIAIAED-G 736
A+ + ++EN ++ Q+ + + + I + DI++ E G
Sbjct: 565 AY---VGALRENEP--SVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYG 619
Query: 737 TIFTQKPLDREK--RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEG 794
I +PLD E+ + +TV+A + G VTI + DENDNPP F Y
Sbjct: 620 VISVSRPLDYEQISNGLIYLTVMA-MDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFV 678
Query: 795 FIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLD 854
++EN G + N + E +Y+L EG F ++ +G + LD
Sbjct: 679 SVVENIMAGATVLFLNATDLDRSREYGQESIIYSL--EGSTQFRINARSGEITTTS-LLD 735
Query: 855 REKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTA 914
RE K SE LI+ D + N K I T
Sbjct: 736 RETK----------------SEYILIVRAVDGG--------VGHNQKTGI-------ATV 764
Query: 915 GFTIIEVKPKNKFALDVDQLGPLFL-IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
T++++ + D P ++ + E P + + + A+D D G NG + Y
Sbjct: 765 NITLLDINDNHPTWKDA----PYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ-- 818
Query: 974 VYIPPSKL-SADALEVKRYFVINERHGHVIVARSLPPESEF--RLNISALDGGN--LNDN 1028
PP+K S ++ K I H + P E+E ++ +S D G L
Sbjct: 819 ---PPNKFYSLNSTTGK----IRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKAT 871
Query: 1029 ISVRVFVK--DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQP 1086
S VFV D+ND+ P F+ + V E + +V A D D G N ++Y +
Sbjct: 872 SSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPV 931
Query: 1087 SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+ F I+ +GV+ ELDRE +Y L VVA D G DVND
Sbjct: 932 GMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAG-TPTKSSTSTLTIHVLDVND 990
Query: 1147 NSPKFY 1152
+P F+
Sbjct: 991 ETPTFF 996
Score = 97.1 bits (231), Expect = 4e-19
Identities = 117/419 (27%), Positives = 173/419 (41%), Gaps = 53/419 (12%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
E IP G +I ++ A+DLD GLNG + Y V +P + F+IN G V
Sbjct: 901 EGIPAGVSIYQVVAIDLDEGLNGLVSYRM--PVGMP-----------RMDFLINSSSGVV 947
Query: 1002 IVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ L E +E++L + A D G + ++ + V DVND P F YN +V E
Sbjct: 948 VTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSED 1007
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYI 1117
+ ++ TD D G NA L+YFI + D F + V+ LDRET Y+
Sbjct: 1008 VPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYM 1067
Query: 1118 LTVVARDNG-XXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESV 1176
L + A DNG DVNDN P F E PE D H S+
Sbjct: 1068 LILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIF--LQSSYEASVPE-DIPEGH---SI 1121
Query: 1177 MMIPVYKATIEENAPIGTTVAKVFAND--TDF-IGNGNGLILYS---LPQRKNQQ----- 1225
+ + KAT + G ++ + +F I NGL++ L + +N
Sbjct: 1122 LQL---KATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIV 1178
Query: 1226 ---NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYY-ELEIEENVNAPVELVSLNL 1281
N L + S+ ++V V D+ DE PVF + Y L + E ++ +
Sbjct: 1179 EAYNHDLGPMRSSVRVIVYVEDINDEA-----PVFTQQQYSRLGLRETAGIGTSVIVVQA 1233
Query: 1282 TEH--YENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
T+ + + Y IL + F ID G + V D E K +Y + V A Q
Sbjct: 1234 TDRDSGDGGLVNYRIL----SGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQ 1288
Score = 95.5 bits (227), Expect = 1e-18
Identities = 131/529 (24%), Positives = 222/529 (41%), Gaps = 58/529 (10%)
Query: 440 MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
+ + V++TL++ NDN P+F LY S+ N VGT + V A D D G G V Y
Sbjct: 441 VGYAKVKITLINENDNRPIF-SQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF 499
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTI 557
+ F ++ +TG + + E R L + A D + R + V+ +
Sbjct: 500 SDDPD-----RFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDV 554
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYE 615
++P F Y + N T + ++R D+ N ++Y ++
Sbjct: 555 ---------NDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASA 605
Query: 616 EGVPFAVE--ERSGVITVVD--DLSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVDVN 670
G F + E GVI+V D + + + +A+ N L+ T+ V D N
Sbjct: 606 FGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDEN 665
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
D K A+ + V+ AGA + + T++ G ++ I + + T
Sbjct: 666 DNPPTFSKPAY--FVSVVENIMAGATVLFLNATDLDRSREYGQESI---IYSLEGSTQFR 720
Query: 731 AIAEDGTIFTQKPLDREKRDVYRMTVIA-EFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
A G I T LDRE + Y + V A + G GI V I + D NDN P ++
Sbjct: 721 INARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKD 780
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFI 849
A Y ++E + +++ + A D D G N +Y++ K + ++ TG ++
Sbjct: 781 APYYINLVEMTPPDSDV---TTVVAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTT 836
Query: 850 GDSLDREK------KIMYKLSLVARDTG----GLSSEAELIIMIGDENDNKPEFNQIEEN 899
LDRE ++M K+ + D G +S A + + + D NDN P F +
Sbjct: 837 HAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFV 896
Query: 900 SKVRIHRETKLNG-TAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIG 947
++V L G AG +I +V A+D+D+ G L+ +P+G
Sbjct: 897 AEV-------LEGIPAGVSIYQV-----VAIDLDE-GLNGLVSYRMPVG 932
Score = 93.9 bits (223), Expect = 4e-18
Identities = 91/329 (27%), Positives = 146/329 (44%), Gaps = 23/329 (6%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIFK 142
V + + DVNDN P F + PY V + E TP G IF++ P L +V
Sbjct: 118 VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTP--IFIVNATDPDLGAGGSVLYSFQPPS 175
Query: 143 DIRAFDRDKPN-TPNSDVHYSIVSGNDDGHFALESSH-KPVLLLRK--VLDYDAGDKEFQ 198
A D + T ++ Y A + +P+ L ++ D D +
Sbjct: 176 QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPI 235
Query: 199 LVIMASGKRIHKEI---LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFL 255
+ + I++ I AIDQD G + Y ++SGN +F+LD ++G L L
Sbjct: 236 FINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTL 295
Query: 256 EKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV----EIELLDLNDNLPEFEVDFY 311
LD E+ L ++ F+L V+ ++LN+ + A V I ++D+NDN PEF Y
Sbjct: 296 NGL--LDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEY 353
Query: 312 NISIVENLPNGFSV---LQVMATDKDQGENGEF-TYQLDDPKGAFSIDPRS----GWLTV 363
+++I E GF++ +QV+ D++ G N F Y + + F I P S + +
Sbjct: 354 SVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRI 413
Query: 364 RNQTVLDREAHSSLRMKVYAKETNPSVVG 392
R LD E ++A E+ P VG
Sbjct: 414 RVAIPLDYETVDRYDFDLFANESVPDHVG 442
Score = 87.4 bits (207), Expect = 3e-16
Identities = 93/351 (26%), Positives = 154/351 (43%), Gaps = 24/351 (6%)
Query: 85 VYIEDVNDNVPIFLDTP--YHVTVDELTPTGEKAFIFLIAP---IGPSLTIPLTVPRG-- 137
V I D+NDN P+ +++P Y+V+V+E G A + + A IG + + + G
Sbjct: 1515 VTILDINDNPPV-IESPFGYNVSVNE-NVGGGTAVVQVRATDRDIGINSVLSYYITEGNK 1572
Query: 138 -LTIFKD-IRAFDRDKPNTPNSD---VHYSIVSGNDDGHFALESS-HKPVLLLRKVLDYD 191
+T D I +P P+ + ++ + + D+G L ++ H V ++ + +
Sbjct: 1573 DMTFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAP 1632
Query: 192 AGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
+ V++ G L I A+D D G T+ Y +++GN F +D G
Sbjct: 1633 MFQQPHYEVLLDEGPDTLNTSLIT--IQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMG 1690
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
+ KELD + H Q L++ L T+ V + + D+NDN+P F D+
Sbjct: 1691 VITAAKELDYEISHGRYTLIVTATDQCPILSHRL-TSTTTVLVNVNDINDNVPTFPRDYE 1749
Query: 312 N-ISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTV 368
+ E P G V +A D+D G NG+ Y + DP G F I P G L VR
Sbjct: 1750 GPFEVTEGQP-GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVE 1808
Query: 369 LDREAHSSLRMKVYAKETN-PSVVGTFADSQRIAKWR-RQPLETNAPLEKT 417
LDRE + + + A++ P + T R+ P+ N P+ T
Sbjct: 1809 LDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNIT 1859
Score = 87.0 bits (206), Expect = 5e-16
Identities = 134/517 (25%), Positives = 211/517 (40%), Gaps = 72/517 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPE+ P+G + + A D D+G NGQ+ V+ S A A E+ N+ G
Sbjct: 1428 IPEDCPVGQRVATVKAWDPDAGSNGQV-------VFSLASGNIAGAFEI---VTTNDSIG 1477
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFKKTW-YNFN 1053
V VAR L E + L + A D G D+I ++V + D+ND+ PV + + YN +
Sbjct: 1478 EVFVARPLDREELDHYILQVVASDRGTPPRKKDHI-LQVTILDINDNPPVIESPFGYNVS 1536
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVN-GELDRET 1112
V E + +V ATD D G N+ L+Y+I + D+ F + ++G ++ DRE
Sbjct: 1537 VNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMTFRMDRISGEIATRPAPPDRER 1596
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYA--FDELLEWKHPEADELSN 1170
+ Y L D G D NDN+P F ++ LL+ + P+ S
Sbjct: 1597 QSFYHLVATVEDEG-TPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLD-EGPDTLNTSL 1654
Query: 1171 HNFESVMMIPVYKATIEENAPIGTTV----------AKVFANDTDF-IGNGNGLILYSLP 1219
+++ + T+ G V A + D+ I +G ++ +
Sbjct: 1655 ITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVT-- 1712
Query: 1220 QRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSL 1279
+Q + L+ST ++V V D+ D V P F R YE E P V
Sbjct: 1713 -ATDQCPILSHRLTSTTTVLVNVNDINDNV-----PTF-PRDYEGPFEVTEGQPGPRVWT 1765
Query: 1280 NLTEHYE---NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSP--DREVKDTYEVIVR 1334
L + N ++ Y I+ D D FVI P G L + + DRE Y + +
Sbjct: 1766 FLAHDRDSGPNGQVEYSIM---DGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTIC 1822
Query: 1335 AERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTT 1394
A R +P P++ +L G +R+ D+NDN P N P+ I
Sbjct: 1823 AR----DRGMP----PLSSTMLVG---------IRVLDINDNDPVLL--NLPMNITISEN 1863
Query: 1395 AP---FGYQVMQLKGAIGHHPTASRTVRADTDELVFF 1428
+P F V+ G + + + A E FF
Sbjct: 1864 SPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFF 1900
Score = 81.4 bits (192), Expect = 2e-14
Identities = 113/492 (22%), Positives = 204/492 (41%), Gaps = 54/492 (10%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + +LD ND P F + S+ N GT + + A D D G NG + Y L+
Sbjct: 2493 VQVVIQVLDVNDCRPQFSKPQ-FSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGP 2551
Query: 503 SNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F ++ ++G V+ + +L V A+D P L V I+V
Sbjct: 2552 G----VEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVN-- 2605
Query: 563 TKGNKPDIPDFMGAPYE--FWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLH--GYEE 616
N+P F+ P + + + ++V ++ D E V Y L G +
Sbjct: 2606 --DNRPV---FVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRD 2660
Query: 617 GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV--DVNDERG 674
F ++ SG+I L R ++ +Y VA + T + V D++D
Sbjct: 2661 WEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEP 2720
Query: 675 VLL---KGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
+ + KG+ + V E+S G +G + + + G F+ A ++ +
Sbjct: 2721 LFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGA-VDADEGPNAIVYYFIAAGNEE--KNF 2777
Query: 731 AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKG------------VISGAGIYQVTIYIE 778
+ DG + + LDRE+ ++ V A N+ +++ + +V + +E
Sbjct: 2778 HLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLE 2837
Query: 779 DENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG--EGKEM 836
D ND PP F A Y + ++K+G+E+ + A DAD G N+L Y++ + +
Sbjct: 2838 DINDQPPRFTKAEYTAGVATDAKVGSELIQ---VLALDADIGNNSLVFYSILAIHYFRAL 2894
Query: 837 FDVDENTGVVKFIG--DSLDREKKIM-------YKLSLVARDTGGLSSEAEL-IIMIGDE 886
+ E+ G V +G D + R + + + +VARD G + A + I ++ D+
Sbjct: 2895 ANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDD 2954
Query: 887 NDNKPEFNQIEE 898
K N+I +
Sbjct: 2955 QRVKIVINEIPD 2966
Score = 80.6 bits (190), Expect = 4e-14
Identities = 47/148 (31%), Positives = 78/148 (52%), Gaps = 4/148 (2%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G A + Y L G + F+++ G +++ LD + + +
Sbjct: 2424 VTATDADSGNFALIEYSLGDGESK--FAINPTTGDIYVLSSLDREKKDHYILTALAKDNP 2481
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
+N + + +V I++LD+ND P+F ++ S+ EN P G SV+ +MATD+D+G
Sbjct: 2482 GDVASNRRENS-VQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGP 2540
Query: 338 NGEFTYQLDDP-KGAFSIDPRSGWLTVR 364
NGE TY L+ P AF +D SG +T +
Sbjct: 2541 NGELTYSLEGPGVEAFHVDMDSGLVTTQ 2568
Score = 80.2 bits (189), Expect = 5e-14
Identities = 128/492 (26%), Positives = 206/492 (41%), Gaps = 65/492 (13%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
E++P+GT I+ + A D DSG I Y E K F IN G +
Sbjct: 2413 EDVPVGTIILTVTATDADSGNFALIEYSLGDG-------------ESK--FAINPTTGDI 2457
Query: 1002 IVARSLPPESEFRLNISALDGGNLND--------NISVRVFVKDVNDHFPVFKKTWYNFN 1053
V SL E + ++AL N D ++ V + V DVND P F K ++ +
Sbjct: 2458 YVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTS 2517
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETE 1113
V E + + + ATD D G N LTY ++ + F + +G+++ L ++
Sbjct: 2518 VYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA-FHVDMDSGLVTTQRPL--QSY 2574
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNF 1173
+K+ LTVVA D G DVNDN P F E L ++ +
Sbjct: 2575 EKFSLTVVATDGGEPPLWGTTMLLVEVI-DVNDNRPVFVRPPNGTILHIREEIPLRSNVY 2633
Query: 1174 ESVMMIPVYKATIEE--NAPIGTTVAKVFAN-DTDF--IGNGNGLILYSLPQRKNQQ--- 1225
E VY +E N + + K N D +F I +GLI + + Q
Sbjct: 2634 E------VYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY 2687
Query: 1226 -------NLGLPSLSSTAI-LMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELV 1277
+LG P T L V + D+ D + +P S Y+L + ++P +
Sbjct: 2688 SLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQL-LTVPEHSPRGTL 2746
Query: 1278 SLNLT-----EHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVI 1332
N+T + N + Y+I N+ + F + P +G L ++R DRE + + I
Sbjct: 2747 VGNVTGAVDADEGPNAIVYYFIAAGNE---EKNFHLQP-DGCLLVLRDLDREREAIFSFI 2802
Query: 1333 VRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIP 1392
V+A + S P P D++ +T +V+VV ++D+ND P+FT +
Sbjct: 2803 VKASSNR-SWTPPRGPSPTL-DLVADLTLQEVRVV--LEDINDQPPRFTKAE--YTAGVA 2856
Query: 1393 TTAPFGYQVMQL 1404
T A G +++Q+
Sbjct: 2857 TDAKVGSELIQV 2868
Score = 78.2 bits (184), Expect = 2e-13
Identities = 56/175 (32%), Positives = 88/175 (50%), Gaps = 12/175 (6%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
+ G ++ ++PLDRE + + + ++GVI+ +V I + D NDN P F + Y
Sbjct: 83 DTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITR----KVNIQVGDVNDNAPTFHNQPYS 138
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
I EN+ +GT I I+ ATD D G +Y+ F + F +D G+V I + L
Sbjct: 139 VRIPENTPVGTPI---FIVNATDPDLGAGGSVLYS-FQPPSQFFAIDSARGIVTVIRE-L 193
Query: 854 DREKKIMYKLSLVARD---TGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIH 905
D E Y+L++ A D T LS+ A L I+I D D P F + ++ + H
Sbjct: 194 DYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEH 248
Score = 77.8 bits (183), Expect = 3e-13
Identities = 54/177 (30%), Positives = 86/177 (48%), Gaps = 9/177 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSL-DSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A+D D G+ + Y L+ L DS G + + +D + H L V
Sbjct: 2318 VAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLN-----FTV 2372
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+AS +P + A+ V +E++D+NDN P F+ Y ++ E++P G +L V ATD D G
Sbjct: 2373 RASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSG 2432
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
Y L D + F+I+P +G + V + LDRE + AK+ NP V +
Sbjct: 2433 NFALIEYSLGDGESKFAINPTTGDIYVLSS--LDREKKDHYILTALAKD-NPGDVAS 2486
Score = 76.6 bits (180), Expect = 6e-13
Identities = 53/164 (32%), Positives = 83/164 (50%), Gaps = 12/164 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTFVL 274
+ A D D G + + L SGN F + + N G +F+ + LD + + + ++L
Sbjct: 1441 VKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDRE-----ELDHYIL 1495
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDK 333
QV AS P + +++ +LD+NDN P E F YN+S+ EN+ G +V+QV ATD+
Sbjct: 1496 QVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDR 1555
Query: 334 DQGENGEFTYQLDDPKG--AFSIDPRSGWLTVRNQTVLDREAHS 375
D G N +Y + + F +D SG + R DRE S
Sbjct: 1556 DIGINSVLSYYITEGNKDMTFRMDRISGEIATR-PAPPDRERQS 1598
Score = 74.5 bits (175), Expect = 3e-12
Identities = 84/328 (25%), Positives = 137/328 (41%), Gaps = 25/328 (7%)
Query: 77 ISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIF--LIAPIGPSLTIPLTV 134
+S ++ + I DV D PIF++ PY + E +P G I + G I T+
Sbjct: 216 LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI 275
Query: 135 PRGLTIFKDIRAFDR-----------DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLL 183
G T I A D D+ N S V G + S
Sbjct: 276 VSGNT--NSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTT 333
Query: 184 LR-KVLDYDAGDKEFQLVIMASGKRIHKEILFPEP--IHAIDQDLGVGATLRYEL-ISGN 239
V+D + EF + ++ F P I +D+D +G +E+ + GN
Sbjct: 334 FNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGN 393
Query: 240 DRKLFSLD--SVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELL 297
+ F + SV G + + + ++ + + + A++ + P A+V+I L+
Sbjct: 394 NSHHFIISPTSVQGKADIRIRVAIPLDYET-VDRYDFDLFANE-SVPDHVGYAKVKITLI 451
Query: 298 DLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPR 357
+ NDN P F YNIS+ EN+ G SVL V+ATD D G GE +Y D FS+D
Sbjct: 452 NENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKD 511
Query: 358 SGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+G + + + LD E + + A++
Sbjct: 512 TGLIMLIAR--LDYELIQRFTLTIIARD 537
Score = 73.7 bits (173), Expect = 5e-12
Identities = 87/331 (26%), Positives = 138/331 (41%), Gaps = 22/331 (6%)
Query: 73 GLNQISAYLSVTVYIE--DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLT- 129
G + A S TV++ D+NDN P F + P+ V E P G + + + L
Sbjct: 864 GRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNG 923
Query: 130 -----IPLTVPRGLTIFKDIRAFDRDKPNTPNSDV-HYSIVSGNDDGHFALESSHKPVLL 183
+P+ +PR + + Y + D +SS + +
Sbjct: 924 LVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTI 983
Query: 184 LRKVLDY-DAGDKEFQLVIMAS-GKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDR 241
VLD D F V S + + +E ++ D D+G+ A L Y + GN
Sbjct: 984 --HVLDVNDETPTFFPAVYNVSVSEDVPREFRVVW-LNCTDNDVGLNAELSYFITGGNVD 1040
Query: 242 KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLND 301
FS+ + + + LD E A +L+ + T A V + +LD+ND
Sbjct: 1041 GKFSVGYRDA--VVRTVVGLDRE-TTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVND 1097
Query: 302 NLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSG 359
N P F Y S+ E++P G S+LQ+ ATD D+GE G Y++ + F I +G
Sbjct: 1098 NRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNG 1157
Query: 360 WLTVRNQTVLDREAHSS--LRMKVYAKETNP 388
L +R LDRE +SS L ++ Y + P
Sbjct: 1158 -LLMRGPRPLDRERNSSHVLIVEAYNHDLGP 1187
Score = 73.3 bits (172), Expect = 6e-12
Identities = 84/322 (26%), Positives = 134/322 (41%), Gaps = 36/322 (11%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTD 1090
V++ + + ND+ P+F + YN ++ E + V ATD D G ++YF SD
Sbjct: 446 VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF--SDDP 503
Query: 1091 LPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
F + TG++ + LD E ++ LT++ARD G DVNDN P
Sbjct: 504 DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG---GEETTGRVRINVLDVNDNVPT 560
Query: 1151 FY--AFDELLEWKHPEADEL------------SNHNFESVMMIPVYKATIEENAPIGTTV 1196
F A+ L P +L +N S++ + + + + G V
Sbjct: 561 FQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGV 620
Query: 1197 AKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPV 1256
V + D+ NGLI ++ + G P L+ST + + V D E + P
Sbjct: 621 ISV-SRPLDYEQISNGLIYLTV----MAMDAGNPPLNSTVPVTIEVFD-----ENDNPPT 670
Query: 1257 FISRYYELEIEENVNAPVELVSLNLT--EHYENFKMRYYILN-ENDTDIRRTFVIDPRNG 1313
F Y + + EN+ A ++ LN T + + I + E T R I+ R+G
Sbjct: 671 FSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFR----INARSG 726
Query: 1314 TLYLVRSPDREVKDTYEVIVRA 1335
+ DRE K Y +IVRA
Sbjct: 727 EITTTSLLDRETKSEYILIVRA 748
Score = 70.9 bits (166), Expect = 3e-11
Identities = 121/490 (24%), Positives = 194/490 (39%), Gaps = 62/490 (12%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN+ GT ++++ A D D G+N + Y YI F ++ G
Sbjct: 1537 VNENVGGGTAVVQVRATDRDIGINSVLSY------YITEGNKDMT-------FRMDRISG 1583
Query: 1000 HVIVARSLPPESE----FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFN 1053
I R PP+ E + L + D G L+ V V + D ND+ P+F++ Y
Sbjct: 1584 E-IATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVL 1642
Query: 1054 VEEAQYTRRV-LGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRE- 1111
++E T L + A D D G N +TY I + F I GV++ ELD E
Sbjct: 1643 LDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEI 1702
Query: 1112 TEDKYILTVVARDNG--XXXXXXXXXXXXXXXXDVNDNSPKF---YA--FDELLEWKHPE 1164
+ +Y L V A D D+NDN P F Y F+ P
Sbjct: 1703 SHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPR 1762
Query: 1165 ADELSNHNFESVMMIPVYKATIEENAPIG----TTVAKVFANDTDFIGNGNGLILYSLPQ 1220
H+ +S V + +I + P+G + V V D + + Y+L
Sbjct: 1763 VWTFLAHDRDSGPNGQV-EYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTI 1821
Query: 1221 RKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVS 1278
+ G+P LSST ++ + V D+ D + PV ++ + I EN V++ V V
Sbjct: 1822 CARDR--GMPPLSSTMLVGIRVLDIND-----NDPVLLNLPMNITISENSPVSSFVAHVL 1874
Query: 1279 LNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
+ + N ++ + I N R F I+ G + + R DRE Y++ +
Sbjct: 1875 ASDADSGCNARLTFNITAGNR---ERAFFINATTGIVTVNRPLDRERIPEYKLTISV--- 1928
Query: 1339 KYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFG 1398
K + E P + YD+ +++ + D NDN P FT + +P G
Sbjct: 1929 KDNPENPRI----------ARRDYDL-LLIFLSDENDNHPLFTKST--YQAEVMENSPAG 1975
Query: 1399 YQVMQLKGAI 1408
+ L G I
Sbjct: 1976 TPLTVLNGPI 1985
Score = 70.9 bits (166), Expect = 3e-11
Identities = 88/331 (26%), Positives = 134/331 (40%), Gaps = 23/331 (6%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIA---PIGPSLT 129
G +SA V V I D NDN P+F Y V +DE T + I + A GP+ T
Sbjct: 1610 GTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGT 1669
Query: 130 IPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR---- 185
+ + G I R T ++ Y I G + P+L R
Sbjct: 1670 VTYAIVAG-NIVNTFRIDRHMGVITAAKELDYEISHGRYT-LIVTATDQCPILSHRLTST 1727
Query: 186 KVLDYDAGDKEFQLVIMASGKRIHKEILFPEP------IHAIDQDLGVGATLRYELISGN 239
+ + D + E+ +P A D+D G + Y ++ G+
Sbjct: 1728 TTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGD 1787
Query: 240 DRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
F + V G L + K+++LD E N L + A P ++ V I +LD+
Sbjct: 1788 PLGEFVISPVEGVLRVRKDVELDRETIAFYN---LTICARDRGMPPLSSTMLVGIRVLDI 1844
Query: 300 NDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPR 357
NDN P NI+I EN P V V+A+D D G N T+ + + + AF I+
Sbjct: 1845 NDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINAT 1904
Query: 358 SGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
+G +TV LDRE ++ + K+ NP
Sbjct: 1905 TGIVTVNRP--LDRERIPEYKLTISVKD-NP 1932
Score = 69.7 bits (163), Expect = 7e-11
Identities = 61/215 (28%), Positives = 86/215 (40%), Gaps = 21/215 (9%)
Query: 939 LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERH 998
LI E+ P+G+++ +L A D+D+ P E R+F +
Sbjct: 41 LISEDTPVGSSVTQLLAQDMDND----------------PLVFGVSGEEASRFFAVEPDT 84
Query: 999 GHVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
G V + + L E SEF + S D + V + V DVND+ P F Y+ + E
Sbjct: 85 GVVWLRQPLDRETKSEFTVEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPYSVRIPE 143
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKY 1116
+ V+ATD D G ++ Y QP F I G+++V ELD ET Y
Sbjct: 144 NTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF--FAIDSARGIVTVIRELDYETTQAY 201
Query: 1117 ILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
LTV A D DV D P F
Sbjct: 202 QLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIF 236
Score = 68.9 bits (161), Expect = 1e-10
Identities = 87/327 (26%), Positives = 137/327 (41%), Gaps = 27/327 (8%)
Query: 582 VGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRP 641
+ + +G+SV Q+ D ND + G E FAVE +GV+ + L R +
Sbjct: 42 ISEDTPVGSSVTQLLAQDM--DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKS 99
Query: 642 MYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIF 701
+ E ++ ++ + I + V DVND + P + EN+ IF
Sbjct: 100 EFTVE-FSVSDHQGV-ITRKVNIQVGDVNDNAPTF---HNQPYSVRIPENTPVGT--PIF 152
Query: 702 HTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEF 760
N + G+V + Q + AI + G + + LD E Y++TV A
Sbjct: 153 IVNATDPDLGAGGSVLYSF---QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATD 209
Query: 761 NKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEG 820
+ + + I I D D P+F + Y I E+S GT ++ II A D D+G
Sbjct: 210 QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR---IITAIDQDKG 266
Query: 821 TNALFMYTLF-GEGKEMFDVDENTGVVKFIGDSLDREKKIM-YKLSLVARDT----GGLS 874
YT+ G +F +D +GV+ G LDRE + + L + T
Sbjct: 267 RPRGIGYTIVSGNTNSIFALDYISGVLTLNG-LLDRENPLYSHGFILTVKGTELNDDRTP 325
Query: 875 SEAELI----IMIGDENDNKPEFNQIE 897
S+A + I++ D NDN PEFN E
Sbjct: 326 SDATVTTTFNILVIDINDNAPEFNSSE 352
Score = 67.3 bits (157), Expect = 4e-10
Identities = 54/173 (31%), Positives = 80/173 (46%), Gaps = 8/173 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G + Y ++ GN F + NG L + LD E N ++ VL V+
Sbjct: 1124 LKATDADEGEFGRVWYRILHGNHGNNFRIHVSNG-LLMRGPRPLDRERN---SSHVLIVE 1179
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN-ISIVENLPNGFSVLQVMATDKDQG 336
A + + RV + + D+ND P F Y+ + + E G SV+ V ATD+D G
Sbjct: 1180 AYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSG 1239
Query: 337 ENGEFTYQ-LDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
+ G Y+ L +G F ID +G + N LD E +S M V A + P
Sbjct: 1240 DGGLVNYRILSGAEGKFEIDESTGLIITVN--YLDYETKTSYMMNVSATDQAP 1290
Score = 63.7 bits (148), Expect = 5e-09
Identities = 59/211 (27%), Positives = 92/211 (43%), Gaps = 31/211 (14%)
Query: 929 LDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEF-------NSEV 974
LDV+ P+FL +PE+IP G +I++L A D D G G++ Y N +
Sbjct: 1093 LDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRI 1152
Query: 975 YIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVF 1034
++ L + R HV++ + D G + ++ V V+
Sbjct: 1153 HVSNGLLMRGPRPLDR----ERNSSHVLIVEAYNH-----------DLGPMRSSVRVIVY 1197
Query: 1035 VKDVNDHFPVFKKTWYN-FNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPF 1093
V+D+ND PVF + Y+ + E + V ATD D G + Y I S + F
Sbjct: 1198 VEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRIL-SGAEGKF 1256
Query: 1094 EISPLTGVLSVNGELDRETEDKYILTVVARD 1124
EI TG++ LD ET+ Y++ V A D
Sbjct: 1257 EIDESTGLIITVNYLDYETKTSYMMNVSATD 1287
Score = 62.9 bits (146), Expect = 9e-09
Identities = 53/170 (31%), Positives = 77/170 (45%), Gaps = 8/170 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGND-RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D+D + Y ++S + F + G + LD E + L V
Sbjct: 583 LRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ-ISNGLIYLTV 641
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A NP + V IE+ D NDN P F Y +S+VEN+ G +VL + ATD D+
Sbjct: 642 MAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRS 701
Query: 337 -ENGE--FTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
E G+ Y L+ F I+ RSG +T ++LDRE S + V A
Sbjct: 702 REYGQESIIYSLEG-STQFRINARSGEIT--TTSLLDRETKSEYILIVRA 748
Score = 62.5 bits (145), Expect = 1e-08
Identities = 57/225 (25%), Positives = 96/225 (42%), Gaps = 15/225 (6%)
Query: 236 ISGNDR-KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
+SG + + F+++ G ++L + LD + + + F ++ S + +V I
Sbjct: 69 VSGEEASRFFAVEPDTGVVWLRQPLDRETK-----SEFTVEFSVSDHQGVITR---KVNI 120
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
++ D+NDN P F Y++ I EN P G + V ATD D G G Y P F+I
Sbjct: 121 QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180
Query: 355 DPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPS-VVGTFADSQRIAK--WRRQPLETN 411
D G +TV + LD E + ++ V A + + + + T A+ I P+ N
Sbjct: 181 DSARGIVTVIRE--LDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFIN 238
Query: 412 APLEKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNN 456
P Y GT I D+ + T++ N N+
Sbjct: 239 LPYSTNIYEH-SPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNS 282
Score = 61.7 bits (143), Expect = 2e-08
Identities = 59/203 (29%), Positives = 92/203 (45%), Gaps = 23/203 (11%)
Query: 935 GPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVI 994
G + I E IP+ + + ++ A D D GLNG +RY F L +F+I
Sbjct: 2617 GTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSF----------LKTAGNRDWEFFII 2666
Query: 995 NERHGHVIVARSLPPESE--FRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFKK-- 1047
+ G + A+ L ES+ + L + A D G ++V ++D++D+ P+F +
Sbjct: 2667 DPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPP 2726
Query: 1048 ----TWYNFNVEEAQYTRRVLGKV-DATDADFGQNANLTYFIQPSDTDLPFEISPLTGVL 1102
+ V E ++G V A DAD G NA + YFI + + F + P G L
Sbjct: 2727 KGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCL 2785
Query: 1103 SVNGELDRETEDKYILTVVARDN 1125
V +LDRE E + V A N
Sbjct: 2786 LVLRDLDREREAIFSFIVKASSN 2808
Score = 60.5 bits (140), Expect = 5e-08
Identities = 36/141 (25%), Positives = 67/141 (47%), Gaps = 5/141 (3%)
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
N F+++ GS+ ++ ++ + + V+ + + A++ + +LD
Sbjct: 2226 NQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLD 2285
Query: 299 LNDNLPEFE---VDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD--PKGAFS 353
+NDN P+F+ + +Y I+E G +++ V A D D+G NG TY L D P G
Sbjct: 2286 VNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQ 2345
Query: 354 IDPRSGWLTVRNQTVLDREAH 374
++ S + N+TV E H
Sbjct: 2346 LEDSSAGKVIANRTVDYEEVH 2366
Score = 58.4 bits (135), Expect = 2e-07
Identities = 41/126 (32%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D G + Y DR FSLD G + L LD + F L + A
Sbjct: 484 ATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYEL-----IQRFTLTIIAR 536
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
T RV I +LD+NDN+P F+ D Y ++ EN P+ ++++ ATD+D N
Sbjct: 537 DGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNN 594
Query: 340 EFTYQL 345
+ TY +
Sbjct: 595 QITYSI 600
Score = 58.4 bits (135), Expect = 2e-07
Identities = 114/498 (22%), Positives = 199/498 (39%), Gaps = 50/498 (10%)
Query: 83 VTVYIE--DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI--APIGPSLTIPLTVPRGL 138
+ VY+E D+NDN PIF Y V E P G A G I ++ G
Sbjct: 2386 IPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGE 2445
Query: 139 TIFK------DI---RAFDRDKPNTPNSDVHYSI--VSGNDDGHFALESSHKPVLLLRKV 187
+ F DI + DR+K + HY + ++ ++ G A V ++ +V
Sbjct: 2446 SKFAINPTTGDIYVLSSLDREKKD------HYILTALAKDNPGDVASNRRENSVQVVIQV 2499
Query: 188 LDYDAGDKEFQLVIMASGKRIHKEI-LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSL 246
LD + +F ++ ++ + A DQD G L Y L G + F +
Sbjct: 2500 LDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHV 2558
Query: 247 DSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF 306
D +G + ++ L F L V A+ P + +E++D+NDN P F
Sbjct: 2559 DMDSGLVTTQRPLQ-------SYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVF 2611
Query: 307 --EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKG-----AFSIDPRSG 359
+ + I E +P +V +V ATDKD+G NG Y G F IDP SG
Sbjct: 2612 VRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISG 2671
Query: 360 WLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGTFADSQRIAKWRRQPLETNAPLEKTTY 419
+ + LDRE+ + + + A + V ++A + ++ N PL +
Sbjct: 2672 LIQTAQR--LDRESQAVYSLILVASDLGQPVPYETMQPLQVA---LEDIDDNEPL----F 2722
Query: 420 VFPDKVGTKTENIEYYDEQLMSFVNVEVT-LLDANDNNPVFVPSNLYEFSMKSNAKVGTV 478
V P K + + + + + VT +DA++ V + + + N +
Sbjct: 2723 VRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD 2782
Query: 479 IGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEA 538
+ D D + + + ++ +SN + T P +P T+ + L+ + +
Sbjct: 2783 GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSP---TLDLVADLTLQEVRVVLEDI 2839
Query: 539 SDQPANPSERRYSLAVVT 556
+DQP ++ Y+ V T
Sbjct: 2840 NDQPPRFTKAEYTAGVAT 2857
Score = 50.8 bits (116), Expect = 4e-05
Identities = 39/129 (30%), Positives = 63/129 (48%), Gaps = 10/129 (7%)
Query: 230 TLRYELISGNDRK-LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTA 288
T R++ + K LF +D++ G + ++ +D + + + + L V A P +
Sbjct: 1347 TYRFDAYTSTQAKALFKIDAITGVITVQGLVDRE-----KGDFYTLTVVADD-GGPKVDS 1400
Query: 289 QARVEIELLDLNDNLPEFEVDFYN-ISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-- 345
+V I +LD NDN P F+ + +SI E+ P G V V A D D G NG+ + L
Sbjct: 1401 TVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLAS 1460
Query: 346 DDPKGAFSI 354
+ GAF I
Sbjct: 1461 GNIAGAFEI 1469
Score = 49.2 bits (112), Expect = 1e-04
Identities = 79/323 (24%), Positives = 135/323 (41%), Gaps = 34/323 (10%)
Query: 81 LSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIA--PIGPS--LTIPLTVP- 135
+ V + + DVND P F + +V E P G + GP+ LT L P
Sbjct: 2493 VQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPG 2552
Query: 136 -RGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
+ D +P ++V+ D G L + +LL +V+D +
Sbjct: 2553 VEAFHVDMDSGLVTTQRPLQSYEKFSLTVVA-TDGGEPPLWGT---TMLLVEVIDVNDNR 2608
Query: 195 KEFQLVIMASGKRIHKEILFPE---PIHAIDQDLGVGATLRYELI--SGN-DRKLFSLDS 248
F + I +EI ++A D+D G+ +RY + +GN D + F +D
Sbjct: 2609 PVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDP 2668
Query: 249 VNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPL--KTAQARVEIELLDLNDNLPEF 306
++G + + LD +++ + L + AS L P+ +T Q +++ L D++DN P F
Sbjct: 2669 ISGLIQTAQRLDRESQ-----AVYSLILVASDLGQPVPYETMQP-LQVALEDIDDNEPLF 2722
Query: 307 ------EVDFYNISIVENLPNGFSVLQVM-ATDKDQGENGEFTYQL--DDPKGAFSIDPR 357
+ +++ E+ P G V V A D D+G N Y + + + F + P
Sbjct: 2723 VRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP- 2781
Query: 358 SGWLTVRNQTVLDREAHSSLRMK 380
G L V +REA S +K
Sbjct: 2782 DGCLLVLRDLDREREAIFSFIVK 2804
Score = 45.2 bits (102), Expect = 0.002
Identities = 35/137 (25%), Positives = 61/137 (44%), Gaps = 15/137 (10%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G A + Y + +GN+ K F L +G L + ++LD + E +F+++ ++
Sbjct: 2753 AVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIF---SFIVKASSN 2808
Query: 280 QLNNPLKTAQA-----------RVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQV 328
+ P + V + L D+ND P F Y + + G ++QV
Sbjct: 2809 RSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQV 2868
Query: 329 MATDKDQGENGEFTYQL 345
+A D D G N Y +
Sbjct: 2869 LALDADIGNNSLVFYSI 2885
Score = 44.8 bits (101), Expect = 0.002
Identities = 44/152 (28%), Positives = 72/152 (47%), Gaps = 28/152 (18%)
Query: 1233 SSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN--FKM 1290
+ TA + VTV DV D ++P+F+ YE + E++ ++ L T+ E ++
Sbjct: 1083 TGTATVFVTVLDVND-----NRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRV 1137
Query: 1291 RYYILNENDTDIRRTFVIDPRNGTLYLVRSP-DREVKDTYEVIVRAERQKYSRELPHMIY 1349
Y IL+ N + F I NG L P DRE ++ +IV A Y+ +L
Sbjct: 1138 WYRILHGNHGN---NFRIHVSNGLLMRGPRPLDRERNSSHVLIVEA----YNHDL----- 1185
Query: 1350 PVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
G + V+V+V ++D+ND +P FT
Sbjct: 1186 --------GPMRSSVRVIVYVEDINDEAPVFT 1209
Score = 40.7 bits (91), Expect = 0.039
Identities = 40/151 (26%), Positives = 67/151 (44%), Gaps = 12/151 (7%)
Query: 79 AYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS----LTIPLTV 134
A S+ + D+ VP P V ++++ + +F+ P G LT+P
Sbjct: 2685 AVYSLILVASDLGQPVPYETMQPLQVALEDID---DNEPLFVRPPKGSPQYQLLTVPEHS 2741
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
PRG + A D D+ PN+ V+Y I +GN++ +F L+ LL+ + LD + +
Sbjct: 2742 PRGTLVGNVTGAVDADEG--PNAIVYYFIAAGNEEKNFHLQPD--GCLLVLRDLDRER-E 2796
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAIDQDL 225
F ++ AS R P P + DL
Sbjct: 2797 AIFSFIVKASSNRSWTPPRGPSPTLDLVADL 2827
Score = 37.5 bits (83), Expect = 0.37
Identities = 19/51 (37%), Positives = 27/51 (52%), Gaps = 4/51 (7%)
Query: 1441 ATDSDIGINADIRYQILNEQAPR----FAIDPVSGTVRVVAALARDAGRVF 1487
ATD D G+N +RY L R F IDP+SG ++ L R++ V+
Sbjct: 2637 ATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY 2687
Score = 35.1 bits (77), Expect = 2.0
Identities = 21/54 (38%), Positives = 27/54 (50%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI 1084
VRV ++D+ND P F K Y V L +V A DAD G N+ + Y I
Sbjct: 2832 VRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSI 2885
Score = 33.5 bits (73), Expect = 6.0
Identities = 16/45 (35%), Positives = 25/45 (55%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTP 111
+V AG S+ ++T+++ DVND P F Y+V+V E P
Sbjct: 965 VVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVP 1009
>X87241-1|CAA60685.1| 4590|Homo sapiens homologue of Drosophila Fat
protein protein.
Length = 4590
Score = 157 bits (382), Expect = 2e-37
Identities = 150/499 (30%), Positives = 229/499 (45%), Gaps = 46/499 (9%)
Query: 429 TENIEYYD---EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAV 485
T NI YD Q ++ + V ++DANDN P F+ + Y + + +V + I +V+A
Sbjct: 789 TLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQES-YFVEVSEDKEVHSEIIQVEAT 847
Query: 486 DPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQP 542
D DLG NG V Y + LT T F I+ TG V++A P+ L+ H+L +EA DQ
Sbjct: 848 DKDLGPNGHVTYSI-----LTDTDTFSIDSVTGVVNIAR-PLDRELQHEHSLKIEARDQA 901
Query: 543 ANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAF- 601
E + V ++V+ + P P F+ Y V ++ GT + + +D
Sbjct: 902 R---EEPQLFSTVVVKVSLEDVNDNP--PTFIPPNYRVKVREDLPEGTVIMWLEAHDPDL 956
Query: 602 -EQNDVSYDLL-HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQEN--ANLS 657
+ V Y LL HG EG F V++ SG + +V L + +Y+ A + +LS
Sbjct: 957 GQSGQVRYSLLDHG--EG-NFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLS 1013
Query: 658 IVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSA---GAAIGQIFHTNMSSIYGNGT- 713
V VVDVN+ H P+ E A +G + T + G
Sbjct: 1014 STCYVEVEVVDVNEN-------LHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAGRD 1066
Query: 714 GNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQV 773
G +R+ I + V E G I T LDRE Y +TV A ++GV+ + ++
Sbjct: 1067 GEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFAT-DQGVVPLSSFIEI 1125
Query: 774 TIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GE 832
I +ED NDN P Y IMENS + I+A D D +N MY + G
Sbjct: 1126 YIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQ---IEAFDPDSSSNDKLMYKITSGN 1182
Query: 833 GKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNK 890
+ F + TG++ LDRE++ + L + D G S+ A +I+ I DENDNK
Sbjct: 1183 PQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNK 1242
Query: 891 PEFNQIEENSKVRIHRETK 909
P+F +++ K+R+ K
Sbjct: 1243 PQF--LQKFYKIRLPEREK 1259
Score = 140 bits (340), Expect = 3e-32
Identities = 137/467 (29%), Positives = 210/467 (44%), Gaps = 38/467 (8%)
Query: 440 MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
++F V V L D NDN P F + YE ++ S+A GT + K A D D G N + Y +
Sbjct: 2580 VAFCTVNVILTDDNDNAPQFRATK-YEVNIGSSAAKGTSVVK-SASDADEGSNADITYAI 2637
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPI-LEGRH-ALFVEASDQPANPSERRYSLAVVTI 557
+ S ++ +IN +G ++ ES I LE FV A D N S + S+ +V +
Sbjct: 2638 EADSE-SVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVD---NGSPSKESVVLVYV 2693
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGY--- 614
++ + +P F Y F V +V +GT + IR A V Y L+ G
Sbjct: 2694 KILPP----EMQLPKFSEPFYTFTVSEDVPVGTEIDLIR---AEHSGTVLYSLVKGNTPE 2746
Query: 615 -EEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVA--LQENANLSIVTNATVHVVDVND 671
F ++ +SG + + L Y F +A Q++ + + ++ V D ND
Sbjct: 2747 SNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDAND 2806
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTDD 729
V SP + EN G + ++ S G V + + Q +V +
Sbjct: 2807 NSPVF---ESSPYEAFIVENLPGGS--RVIQIRASDADSGTNGQVMYSLDQSQSVEVIES 2861
Query: 730 IAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
AI E G I T K LD EKRD Y++ V+A + I + V + + D ND+PP F
Sbjct: 2862 FAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFT 2921
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNALFMYTLFGE---GKEMFDVDENTG 844
Y+G + E+ G I I+ TDAD E N Y + G G+ + +N
Sbjct: 2922 AEIYKGTVSEDDPQGGVIA---ILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEW 2978
Query: 845 VVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKP 891
V ++ LDREK+ Y L++ A D G SS+A + + + D NDN P
Sbjct: 2979 KV-YVKKPLDREKRDNYLLTITATD-GTFSSKAIVEVKVLDANDNSP 3023
Score = 125 bits (301), Expect = 1e-27
Identities = 199/848 (23%), Positives = 350/848 (41%), Gaps = 93/848 (10%)
Query: 106 VDELTPTGEKAFIFLIAPIGPSLTIP-LTVP-RGLTIFKDIRA-FDRDKPNTPNSD-VHY 161
VD +P+ E + + + P + +P + P T+ +D+ + D +S V Y
Sbjct: 2678 VDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPVGTEIDLIRAEHSGTVLY 2737
Query: 162 SIVSGND-----DGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPE 216
S+V GN D F ++ L L K LD++ K +Q I+A + E+
Sbjct: 2738 SLVKGNTPESNRDESFVIDRQSGR-LKLEKSLDHET-TKWYQFSILARCTQDDHEM---- 2791
Query: 217 PIHAIDQDLGV-GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ ++D + V A + + + F ++++ G + + DA+ +
Sbjct: 2792 -VASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQV-MYS 2849
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV-----ENLP-NGFSVLQVM 329
+ SQ +++ +E + L + D Y I +V E + + +++ V
Sbjct: 2850 LDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVT 2909
Query: 330 ATDKDQGENGEFTYQLDDPKGAFSID-PRSGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
TD + FT ++ KG S D P+ G + + + T D E + +V T
Sbjct: 2910 VTDVNDSPP-RFTAEIY--KGTVSEDDPQGGVIAILSTTDADSE---EINRQVTYFITGG 2963
Query: 389 SVVGTFADSQRIAKWRRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVT 448
+G FA +W+ + PL++ +K I D S VEV
Sbjct: 2964 DPLGQFAVETIQNEWK---VYVKKPLDR------EKRDNYLLTITATDGTFSSKAIVEVK 3014
Query: 449 LLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTIT 508
+LDANDN+PV LY ++ + G +I ++ A D D+ N + Y L +
Sbjct: 3015 VLDANDNSPV-CEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSG----A 3069
Query: 509 SPFKINPNTGTVSVAESPILEGRHA---LFVEASDQPANPSERRYSLAVVTIEVTRGTKG 565
FK+NP+TG + + +P+ A L V A+D + + VVT+E
Sbjct: 3070 EKFKLNPDTGELKTS-TPLDREEQAVYHLLVRATDGGGRFCQ---ASIVVTLEDV----- 3120
Query: 566 NKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGYEEGVPFAVE 623
+ P+F PY V N GT + +++ DA + Y L+ + F++
Sbjct: 3121 -NDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADG--QFSIN 3177
Query: 624 ERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNAT--VHVVDVNDERGVLLKGAH 681
E SG+I + L R + +Y A+ + + T V V+D+ND
Sbjct: 3178 ELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDIND---------- 3227
Query: 682 SPIIFHVKENSAGAAIGQIFHTNMSSIYG-----NGTGNVRFLIANQQDVTDDIAIAEDG 736
+P +F +E A + + T + +Y + + I + + ++ G
Sbjct: 3228 NPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTG 3287
Query: 737 TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFI 796
+F + LD E Y +TV A + G S + + V + + D NDN PVF TY I
Sbjct: 3288 AVFIIENLDYESSHEYYLTVEAT-DGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVI 3346
Query: 797 MENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTGVVKFIGDSLDR 855
E++ + + + A DAD +N+ Y++ G F +D G VK + LDR
Sbjct: 3347 SEDAVLEQSV---ITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVK-VTKLLDR 3402
Query: 856 EKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
E Y L++ A D G + + I + D NDN P F++ N V I N
Sbjct: 3403 ETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSR--GNYSVIIQE----NKP 3456
Query: 914 AGFTIIEV 921
GF+++++
Sbjct: 3457 VGFSVLQL 3464
Score = 124 bits (299), Expect = 2e-27
Identities = 136/476 (28%), Positives = 213/476 (44%), Gaps = 35/476 (7%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
N+ D S V VT++ N ++P F+ N YE + NA + T++ +VK D D G
Sbjct: 2467 NLSVSDGVFRSSTQVHVTVIGGNLHSPAFL-QNEYEVELAENAPLHTLVMEVKTTDGDSG 2525
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRY 550
G V Y + N F IN G + E E A V + A + +
Sbjct: 2526 IYGHVTYHIV---NDFAKDRFYINER-GQIFTLEKLDRE-TPAEKVISVRLMAKDAGGKV 2580
Query: 551 SLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQN--DVSY 608
+ V + +T + + P F YE +GS+ GTSV + +DA E + D++Y
Sbjct: 2581 AFCTVNVILT----DDNDNAPQFRATKYEVNIGSSAAKGTSVVK-SASDADEGSNADITY 2635
Query: 609 DLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHV 666
+ E V + + SGVIT + L + F A+ +N + S + V+V
Sbjct: 2636 -AIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAV-DNGSPSKESVVLVYV 2693
Query: 667 VDVNDERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSI-YGNGTGNVRFLIANQQ 724
+ E L K + F V E+ G I I + ++ Y GN ++
Sbjct: 2694 KILPPEMQ-LPKFSEPFYTFTVSEDVPVGTEIDLIRAEHSGTVLYSLVKGNTPESNRDES 2752
Query: 725 DVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
V D + G + +K LD E Y+ +++A + V+I ++D NDN
Sbjct: 2753 FVID----RQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNS 2808
Query: 785 PVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKEMFDVD 840
PVFE + YE FI+EN G+ + I+A+DAD GTN MY+L E E F ++
Sbjct: 2809 PVFESSPYEAFIVENLPGGSRVIQ---IRASDADSGTNGQVMYSLDQSQSVEVIESFAIN 2865
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTG---GLSSEAELIIMIGDENDNKPEF 893
TG + + + LD EK+ Y++ +VA D G LSS A + + + D ND+ P F
Sbjct: 2866 METGWITTLKE-LDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRF 2920
Score = 122 bits (294), Expect = 1e-26
Identities = 166/700 (23%), Positives = 293/700 (41%), Gaps = 65/700 (9%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G + Y + + N F++D G++ + LD + L + L+++
Sbjct: 485 LSAVDPDEGENGYVTYSIANLNHVP-FAIDHFTGAVSTSENLD----YELMPRVYTLRIR 539
Query: 278 ASQLNNPLKT-AQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
AS P + + I L +LNDN P FE +I +L G + V A D D+
Sbjct: 540 ASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADEL 599
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGTFAD 396
+ ++ + + FS++P SG L+++ SL + AK + S+ T D
Sbjct: 600 QLVQYQIEAGNELDLFSLNPNSGVLSLKR----------SLMDGLGAKVSFHSLRITATD 649
Query: 397 SQRIAKWRRQPLETN---APLEKTTYVFPDKVGTKTENIE--YYDEQLMSFVNVEVTLLD 451
+ A PL N A K + ++ G E +L + VE D
Sbjct: 650 GENFAT----PLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFD 705
Query: 452 ANDNN---PVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTIT 508
++ N P F + +K N VG+ + + + D D G NG ++Y S
Sbjct: 706 SHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVY---AVSGGNED 762
Query: 509 SPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLAVVTIEVTRGTKG 565
S F I+ TG + + SP+ ++ L + D L VV ++
Sbjct: 763 SCFMIDMETGMLKIL-SPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDA-----N 816
Query: 566 NKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVPFAVE 623
+ P P+F+ Y V + + + + Q+ D V+Y +L + F+++
Sbjct: 817 DNP--PEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSILTDTD---TFSID 871
Query: 624 ERSGVITVVDDLSRYNRPMYDFEAVA---LQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+GV+ + L R + + + A +E L V + DVND +
Sbjct: 872 SVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPN 931
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ V+E+ + + + +G VR+ + + + D+ G +
Sbjct: 932 YR---VKVREDLPEGTVIMWLEAHDPDL--GQSGQVRYSLLDHGEGNFDVD-KLSGAVRI 985
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDN--PPVFEHATYEGFIME 798
+ LD EK+ VY +TV A+ +S + V + + D N+N PPVF +G + E
Sbjct: 986 VQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKE 1045
Query: 799 NSKIGTEIKMDNIIKATDADEGTNALFMYTL-FGEGKEMFDVDENTGVVKFIGDSLDREK 857
++ +G+ + + A D D G + Y++ G G +F + E TGV++ D LDRE
Sbjct: 1046 DAPVGSLVM---TVSAHDEDAGRDGEIRYSIRDGSGVGVFKIGEETGVIE-TSDRLDRES 1101
Query: 858 KIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ 895
Y L++ A D G LSS E+ I + D NDN P+ ++
Sbjct: 1102 TSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSE 1141
Score = 120 bits (288), Expect = 5e-26
Identities = 120/463 (25%), Positives = 204/463 (44%), Gaps = 32/463 (6%)
Query: 444 NVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTS 503
++ VTL D NDN P F ++ Y ++ N + GT++ +V+A D D G N +LY L ++
Sbjct: 3112 SIVVTLEDVNDNAPEF-SADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSA 3170
Query: 504 NLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN +G + + E P+ L+ + L ++A DQ RR + A T+ V+
Sbjct: 3171 D----GQFSINELSGIIQL-EKPLDRELQAVYTLSLKAVDQGL---PRRLT-ATGTVIVS 3221
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGV 618
+ P P F Y V ++ +GT V Q+ D +++Y ++ G E G
Sbjct: 3222 VLDINDNP--PVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHG- 3278
Query: 619 PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLL 677
F+++ ++G + ++++L + Y A +LS V V+V D+ND V
Sbjct: 3279 KFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFS 3338
Query: 678 KGAHSPIIFHVKENSAGAAIGQIFHTNMSS-IYGNGTGNVRFLIANQQDVTDDIAIAEDG 736
+ ++ +I S A + Q T M+ G ++ + I + + G
Sbjct: 3339 QDTYTTVI------SEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRG 3392
Query: 737 TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFI 796
+ K LDRE Y +TV A N G V I + D NDN PVF Y I
Sbjct: 3393 EVKVTKLLDRETISGYTLTVQASDN-GSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVII 3451
Query: 797 MENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE 856
EN +G + + ++ D+ F + G ++ F+V N V ++ R+
Sbjct: 3452 QENKPVGFSV-LQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEV--NPQGVLLTSSAIKRK 3508
Query: 857 KKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIE 897
+K Y L + D G LSS + I + +E+ P +E
Sbjct: 3509 EKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLE 3551
Score = 119 bits (286), Expect = 9e-26
Identities = 123/479 (25%), Positives = 209/479 (43%), Gaps = 42/479 (8%)
Query: 432 IEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQ 491
+E D V + ++D ND+ P F S YE + + T I ++ AVD D +
Sbjct: 1429 VEATDGTTTILTQVFIKVIDTNDHRPQFSTSK-YEVVIPEDTAPETEILQISAVDQD--E 1485
Query: 492 NGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHA--LFVEASDQPANPSERR 549
++Y LQ + + F+++P TG++ +E E L V DQ P +R
Sbjct: 1486 KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVSPAHLTVMVRDQDV-PVKRN 1544
Query: 550 YSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVS 607
++ VV + T P F + Y+ V + +G+ V Q+ D + +V
Sbjct: 1545 FARIVVNVSDTND------HAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVL 1598
Query: 608 YDLLHGY--EEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATV 664
Y + G G F ++ G I +L R N+ YD A + + +S +T+ +
Sbjct: 1599 YSIESGNIGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRI 1658
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIF-HTNMSSIYGNGTGNVRFLIANQ 723
V ++ +S + S G+ +G + H+ S +Y GN +
Sbjct: 1659 FVTIADNASPKFTSKEYSVELSETV--SIGSFVGMVTAHSQSSVVYEIKDGNT----GDA 1712
Query: 724 QDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDN 783
D+ GTI TQK LD E +Y + + G+ + V ++++DENDN
Sbjct: 1713 FDINP-----HSGTIITQKALDFETLPIYTLIIQGTNMAGLSTNT---TVLVHLQDENDN 1764
Query: 784 PPVFEHATYEGFIMENSKIGTEIKMDN----IIKATDADEGTNALFMYTLFGEG-KEMFD 838
PVF A Y G I E++ I + + D +I+A DAD+ +NAL +Y + F
Sbjct: 1765 APVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFA 1824
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSE--AELIIMIGDENDNKPEF 893
+D +TG + + SLD E+ ++ ++ D G L +E A + + + D ND P F
Sbjct: 1825 IDSSTGAIHTV-LSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVF 1882
Score = 112 bits (270), Expect = 8e-24
Identities = 127/479 (26%), Positives = 201/479 (41%), Gaps = 62/479 (12%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPE++ G I++++A D D N +I Y KL+ D E+K ++
Sbjct: 3034 IPEDVLPGKLIMQISATDADIRSNAEITYTLLGSG-AEKFKLNPDTGELKTSTPLDREE- 3091
Query: 1000 HVIVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQY 1059
++ + L + A DGG S+ V ++DVND+ P F Y V E
Sbjct: 3092 ----------QAVYHLLVRATDGGGRFCQASIVVTLEDVNDNAPEFSADPYAITVFENTE 3141
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
+L +V ATDAD G N + Y + S D F I+ L+G++ + LDRE + Y L+
Sbjct: 3142 PGTLLTRVQATDADAGLNRKILYSLIDS-ADGQFSINELSGIIQLEKPLDRELQAVYTLS 3200
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D G D+NDN P F E E+ ++++ ++
Sbjct: 3201 LKAVDQGLPRRLTATGTVIVSVLDINDNPPVF----EYREYGATVSEDI----LVGTEVL 3252
Query: 1180 PVYKAT--IEENAPIGTTVAKVFANDTDFIGNGNG--LILYSLPQRKNQQ--------NL 1227
VY A+ IE NA I ++ + I + G I+ +L + + +
Sbjct: 3253 QVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDG 3312
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSLNLTEHY 1285
G PSLS A + V V D+ D + PVF Y I E+ + V V + +
Sbjct: 3313 GTPSLSDVATVNVNVTDIND-----NTPVFSQDTYTTVISEDAVLEQSVITVMADDADGP 3367
Query: 1286 ENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
N + Y I++ N +F IDP G + + + DRE Y + V+A P
Sbjct: 3368 SNSHIHYSIIDGNQGS---SFTIDPVRGEVKVTKLLDRETISGYTLTVQAS----DNGSP 3420
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQL 1404
+ V + + DVNDN+P F+ GN ++ I P G+ V+QL
Sbjct: 3421 PRVNTTT-------------VNIDVSDVNDNAPVFSRGNYSVI--IQENKPVGFSVLQL 3464
Score = 109 bits (263), Expect = 6e-23
Identities = 129/447 (28%), Positives = 188/447 (42%), Gaps = 30/447 (6%)
Query: 436 DEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMV 495
+ QL S V V+V+L D NDN P F+P N Y ++ + GTVI ++A DPDLGQ+G V
Sbjct: 904 EPQLFSTVVVKVSLEDVNDNPPTFIPPN-YRVKVREDLPEGTVIMWLEAHDPDLGQSGQV 962
Query: 496 LYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLA 553
Y L F ++ +G V + + E + + L V A D+ S S
Sbjct: 963 RYSLLDHGE----GNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVS--LSSTC 1016
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN--DAFEQNDVSYDLL 611
V +EV + P P F + V + +G+ V + + DA ++ Y +
Sbjct: 1017 YVEVEVVDVNENLHP--PVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAGRDGEIRYSIR 1074
Query: 612 HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQEN-ANLSIVTNATVHVVDVN 670
G GV F + E +GVI D L R + Y A + LS + V DVN
Sbjct: 1075 DGSGVGV-FKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVN 1133
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
D + + P I + F + SS N + N Q
Sbjct: 1134 DNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSS---NDKLMYKITSGNPQGFFS-- 1188
Query: 731 AIAEDGTI-FTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
+ G I T + LDRE++D + + V N G + I +V + I DENDN P F
Sbjct: 1189 IHPKTGLITTTSRKLDREQQDEHILEVTVTDN-GSPPKSTIARVIVKILDENDNKPQFLQ 1247
Query: 790 ATYEGFIMENSKIGTE--IKMDNIIK--ATDADEGTNALFMYTL-FGEGKEMFDVDENTG 844
Y+ + E K E + + + + ATD DEG NA Y++ G F ++ TG
Sbjct: 1248 KFYKIRLPEREKPDRERNARREPLYRVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTG 1307
Query: 845 VVKFIGDSLDREKKIMYKLSLVARDTG 871
VV S E I LS+ A D G
Sbjct: 1308 VVSSKRFSAAGEYDI---LSIKAVDNG 1331
Score = 109 bits (262), Expect = 7e-23
Identities = 196/795 (24%), Positives = 328/795 (41%), Gaps = 86/795 (10%)
Query: 620 FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKG 679
F++ +G+I++++ + R ++ E A+ T V V+ N +
Sbjct: 411 FSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKAS----TKVLVKVLGANSNPPEFTQT 466
Query: 680 AHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNG-TGNVRFLIANQQDVTDDIAIAE-DGT 737
A+ EN IG + + G G V + IAN V AI G
Sbjct: 467 AYKAAF---DEN---VPIGTTIMSLSAVDPDEGENGYVTYSIANLNHVP--FAIDHFTGA 518
Query: 738 IFTQKPLDREKRD-VYRMTVIAEFNKGVISGAGIYQV-TIYIEDENDNPPVFEHATYEGF 795
+ T + LD E VY + + A + G+ + + TI + + NDN P+FE EG
Sbjct: 519 VSTSENLDYELMPRVYTLRIRAS-DWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGT 577
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTL-FGEGKEMFDVDENTGVVKFIGDSLD 854
I + +G +I + A DADE L Y + G ++F ++ N+GV+ +D
Sbjct: 578 IPRDLGVGEQI---TTVSAIDADE--LQLVQYQIEAGNELDLFSLNPNSGVLSLKRSLMD 632
Query: 855 R--EKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNG 912
K + L + A D G + L I I +K Q EE ++ E L
Sbjct: 633 GLGAKVSFHSLRITATD--GENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQA 690
Query: 913 TAGFTIIEVKPKNKFALDVDQLGPLFL--------IPENIPIGTTIIKLNALDLDSGLNG 964
EV+ + V+ P F + EN P+G+++I +N+ DLD+G NG
Sbjct: 691 NKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNG 750
Query: 965 QIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDG 1022
++ Y + + D+ F+I+ G + + L E+ ++ LNI+ D
Sbjct: 751 KLVYAVSGG--------NEDSC-----FMIDMETGMLKILSPLDRETTDKYTLNITVYDL 797
Query: 1023 GNLNDNI--SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANL 1080
G + V V D ND+ P F + Y V E + + +V+ATD D G N ++
Sbjct: 798 GIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHV 857
Query: 1081 TYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXX-XXXXXXXXXX 1139
TY I +DTD F I +TGV+++ LDRE + ++ L + ARD
Sbjct: 858 TYSIL-TDTD-TFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKV 915
Query: 1140 XXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKV 1199
DVNDN P F ++ ++L +M + + + ++ + ++
Sbjct: 916 SLEDVNDNPPTFIP----PNYRVKVREDLPEGTV--IMWLEAHDPDLGQSGQVRYSLLDH 969
Query: 1200 FAN--DTDFIGNGNGLILYSLPQRKNQQNL-------GLP-SLSSTAILMVTVADVPDEV 1249
D D + ++ ++K NL G P SLSST + V V DV + +
Sbjct: 970 GEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENL 1029
Query: 1250 EMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF----KMRYYILNENDTDIRRT 1305
PVF S + ++E +APV + + ++ H E+ ++RY I + + +
Sbjct: 1030 H---PPVFSSFVEKGTVKE--DAPVGSLVMTVSAHDEDAGRDGEIRYSIRDGSGVGV--- 1081
Query: 1306 FVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHM-IYPVAEDVLEGMTKYDV 1364
F I G + DRE Y + V A Q + IY EDV + +
Sbjct: 1082 FKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQ--T 1139
Query: 1365 KVVVRIKDVNDNSPK 1379
V ++ +NSPK
Sbjct: 1140 SEPVYYPEIMENSPK 1154
Score = 98.7 bits (235), Expect = 1e-19
Identities = 91/325 (28%), Positives = 142/325 (43%), Gaps = 24/325 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPL------TVP 135
S+ V +EDVNDN P F PY +TV E T G L + +
Sbjct: 3112 SIVVTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSAD 3171
Query: 136 RGLTIFKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
+I + +KP Y++ + D G ++ V++ VLD +
Sbjct: 3172 GQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIV--SVLDINDNP 3229
Query: 195 KEFQLVIMASGKRIHKEILFPEPI---HAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F+ G + ++IL + +A +D+ A + Y +ISGN+ FS+DS G
Sbjct: 3230 PVFE--YREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTG 3287
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
++F+ + LD ++ H + L V+A+ P + A V + + D+NDN P F D Y
Sbjct: 3288 AVFIIENLDYESSHE-----YYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTY 3342
Query: 312 NISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK--GAFSIDPRSGWLTVRNQTVL 369
I E+ SV+ VMA D D N Y + D +F+IDP G V+ +L
Sbjct: 3343 TTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRG--EVKVTKLL 3400
Query: 370 DREAHSSLRMKVYAKET-NPSVVGT 393
DRE S + V A + +P V T
Sbjct: 3401 DRETISGYTLTVQASDNGSPPRVNT 3425
Score = 98.3 bits (234), Expect = 2e-19
Identities = 126/474 (26%), Positives = 200/474 (42%), Gaps = 35/474 (7%)
Query: 430 ENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDL 489
E IE + ++ V V+V + D NDN PVFV Y +K + +VG VI V AVD D
Sbjct: 2055 EVIEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV-VKVDTEVGHVIRYVTAVDRDS 2113
Query: 490 GQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVA---ESPILEGRHALFVEASDQPANPS 546
G+NG V Y L+ F+I P G +S+ E L + + V A D NP+
Sbjct: 2114 GRNGEVHYYLKEHHE-----HFQIGP-LGEISLKKQFELDTLNKEYLVTVVAKDG-GNPA 2166
Query: 547 ERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDV 606
+S V+ + +T K +P F Y + ++ + + V ++ N E V
Sbjct: 2167 ---FSAEVI-VPITVMNKA----MPVFEKPFYSAEIAESIQVHSPVVHVQANSP-EGLKV 2217
Query: 607 SYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHV 666
Y + G + F + +GVI V+ L P Y A + V
Sbjct: 2218 FYSITDG-DPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIV 2276
Query: 667 VDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDV 726
D+ND V + +++ + + G ++ Q+ T+ S G F N
Sbjct: 2277 DDINDNPPVFAQQSYAVTLSEA--SVIGTSVVQVRATDSDSEPNRGISYQMF--GNHSKS 2332
Query: 727 TDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP 785
D + + G I + LD E+ + + V A + G+ + + VT+ + D N NPP
Sbjct: 2333 HDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRA-VDGGMPTLSSDVIVTVDVTDLNGNPP 2391
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYT-LFGEGKEMFDVDENTG 844
+FE YE I E++ G + +KA DAD Y+ L G + F +D TG
Sbjct: 2392 LFEQQIYEARISEHAPHGHFV---TCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATG 2448
Query: 845 VVKFIGDSLDREK-KIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIE 897
++ +L R K Y L+L D G S ++ + + N + P F Q E
Sbjct: 2449 IITL--SNLHRHALKPFYSLNLSVSD-GVFRSSTQVHVTVIGGNLHSPAFLQNE 2499
Score = 96.7 bits (230), Expect = 6e-19
Identities = 125/459 (27%), Positives = 186/459 (40%), Gaps = 64/459 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I EN+P G+ +I++ A D DSG NGQ+ Y + + ++EV F IN G
Sbjct: 2820 IVENLPGGSRVIQIRASDADSGTNGQVMYSLDQ----------SQSVEVIESFAINMETG 2869
Query: 1000 HVIVARSLPPESE--FRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFKKTWYNFNV 1054
+ + L E +++ + A D G L+ V V V DVND P F Y V
Sbjct: 2870 WITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTV 2929
Query: 1055 EEAQYTRRVLGKVDATDADFGQ-NANLTYFIQPSDTDLPFEISPLTG--VLSVNGELDRE 1111
E V+ + TDAD + N +TYFI D F + + + V LDRE
Sbjct: 2930 SEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDRE 2989
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
D Y+LT+ A D D NDNSP L PE D L
Sbjct: 2990 KRDNYLLTITATDG----TFSSKAIVEVKVLDANDNSP--VCEKTLYSDTIPE-DVLPG- 3041
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPS 1231
+ +M I A I NA I T+ A + G + S P + +Q +
Sbjct: 3042 --KLIMQISATDADIRSNAEITYTLLGSGAEKFK-LNPDTGELKTSTPLDREEQAVYHLL 3098
Query: 1232 LSST--------AILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTE 1283
+ +T A ++VT+ DV D + P F + Y + + EN L + T+
Sbjct: 3099 VRATDGGGRFCQASIVVTLEDVND-----NAPEFSADPYAITVFENTEPGTLLTRVQATD 3153
Query: 1284 HYE--NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYS 1341
N K+ Y +++ D F I+ +G + L + DRE++ Y + ++A Q
Sbjct: 3154 ADAGLNRKILYSLIDSADGQ----FSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLP 3209
Query: 1342 RELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF 1380
R L G V+V + D+NDN P F
Sbjct: 3210 RRL----------TATG------TVIVSVLDINDNPPVF 3232
Score = 91.9 bits (218), Expect = 2e-17
Identities = 102/388 (26%), Positives = 164/388 (42%), Gaps = 39/388 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ E+I +GT ++++ A D N +I Y S +S + F I+ + G
Sbjct: 3241 VSEDILVGTEVLQVYAASRDIEANAEITY----------SIISGNE---HGKFSIDSKTG 3287
Query: 1000 HVIVARSLPPES--EFRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
V + +L ES E+ L + A DGG +L+D +V V V D+ND+ PVF + Y +
Sbjct: 3288 AVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVIS 3347
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E + + V A DAD N+++ Y I + F I P+ G + V LDRET
Sbjct: 3348 EDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISG 3407
Query: 1116 YILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYA--FDELLEWKHPEADELSNHNF 1173
Y LTV A DNG DVNDN+P F + +++ P F
Sbjct: 3408 YTLTVQASDNG-SPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPV-------GF 3459
Query: 1174 ESVMMIPVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNLGLPSL 1232
+ ++ + + P T+ V ND F N G++L S ++ +++
Sbjct: 3460 SVLQLVVTDEDSSHNGPPFFFTI--VTGNDEKAFEVNPQGVLLTSSAIKRKEKD------ 3511
Query: 1233 SSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENFKMRY 1292
+L V VAD + ++S R E I P+E+ + E Y +
Sbjct: 3512 --HYLLQVKVAD-NGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYSGGVIGK 3568
Query: 1293 YILNENDTDIRRTFVIDPRNGTLYLVRS 1320
+ D T+ +DP+ L+ V S
Sbjct: 3569 IHATDQDVYDTLTYSLDPQMDNLFSVSS 3596
Score = 89.0 bits (211), Expect = 1e-16
Identities = 87/327 (26%), Positives = 144/327 (44%), Gaps = 20/327 (6%)
Query: 67 LVRIGAGL-NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP-- 123
L + GL +++A +V V + D+NDN P+F Y TV E G + A
Sbjct: 3201 LKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRD 3260
Query: 124 IGPSLTIPLTVPRG-----LTIFKDIRA-FDRDKPNTPNSDVHYSIVSGNDDGHFALESS 177
I + I ++ G +I A F + + +S +Y V D G +L
Sbjct: 3261 IEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDV 3320
Query: 178 HKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELIS 237
+ + + D + + S + ++ + + A D D + + Y +I
Sbjct: 3321 ATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVIT--VMADDADGPSNSHIHYSIID 3378
Query: 238 GNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELL 297
GN F++D V G + + K LD + + + L VQAS +P + V I++
Sbjct: 3379 GNQGSSFTIDPVRGEVKVTKLLDRET-----ISGYTLTVQASDNGSPPRVNTTTVNIDVS 3433
Query: 298 DLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGE---FTYQLDDPKGAFSI 354
D+NDN P F Y++ I EN P GFSVLQ++ TD+D NG FT + + AF +
Sbjct: 3434 DVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEV 3493
Query: 355 DPRSGWLTVRNQTVLDREAHSSLRMKV 381
+P+ G L + + H L++KV
Sbjct: 3494 NPQ-GVLLTSSAIKRKEKDHYLLQVKV 3519
Score = 81.8 bits (193), Expect = 2e-14
Identities = 125/482 (25%), Positives = 198/482 (41%), Gaps = 74/482 (15%)
Query: 938 FLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINER 997
F + E++P+GT I DL IR E + V K + FVI+ +
Sbjct: 2712 FTVSEDVPVGTEI------DL-------IRAEHSGTVLYSLVKGNTPESNRDESFVIDRQ 2758
Query: 998 HGHVIVARSLPPESEFRLNISAL-----DGGNLNDNISVRVFVKDVNDHFPVFKKTWYN- 1051
G + + +SL E+ S L D + ++ V + VKD ND+ PVF+ + Y
Sbjct: 2759 SGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEA 2818
Query: 1052 FNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS---DTDLPFEISPLTGVLSVNGEL 1108
F VE RV+ ++ A+DAD G N + Y + S + F I+ TG ++ EL
Sbjct: 2819 FIVENLPGGSRVI-QIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKEL 2877
Query: 1109 DRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYA--FDELLEWKHPEAD 1166
D E D Y + VVA D+G DVND+ P+F A + + P+
Sbjct: 2878 DHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGG 2937
Query: 1167 E---LSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKN 1223
LS + +S + I P+G FA +T I N + + R+
Sbjct: 2938 VIAILSTTDADSEEINRQVTYFITGGDPLGQ-----FAVET--IQNEWKVYVKKPLDREK 2990
Query: 1224 QQNLGLP------SLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELV 1277
+ N L + SS AI+ V V D D + PV Y I E+V ++
Sbjct: 2991 RDNYLLTITATDGTFSSKAIVEVKVLDAND-----NSPVCEKTLYSDTIPEDVLPGKLIM 3045
Query: 1278 SLNLTEH--YENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
++ T+ N ++ Y +L F ++P G L DRE + Y ++VRA
Sbjct: 3046 QISATDADIRSNAEITYTLLGSG----AEKFKLNPDTGELKTSTPLDREEQAVYHLLVRA 3101
Query: 1336 ERQKYSRELPHMIYPVAEDVLEGMTKY-DVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTT 1394
+G ++ +VV ++DVNDN+P+F + + +T T
Sbjct: 3102 --------------------TDGGGRFCQASIVVTLEDVNDNAPEF-SADPYAITVFENT 3140
Query: 1395 AP 1396
P
Sbjct: 3141 EP 3142
Score = 79.8 bits (188), Expect = 7e-14
Identities = 105/458 (22%), Positives = 181/458 (39%), Gaps = 58/458 (12%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I EN P +++++ A D DS N ++ Y+ S + +F I+ + G
Sbjct: 1148 IMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSG-------------NPQGFFSIHPKTG 1194
Query: 1000 HVIV-ARSLPPES--EFRLNISALDGGNLNDNISVRVFVK--DVNDHFPVFKKTWYNFNV 1054
+ +R L E E L ++ D G+ + RV VK D ND+ P F + +Y +
Sbjct: 1195 LITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRL 1254
Query: 1055 EEAQYT-------RRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGE 1107
E + R L +V ATD D G NA ++Y I+ + F I P TGV+S
Sbjct: 1255 PEREKPDRERNARREPLYRVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRF 1314
Query: 1108 LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE 1167
D IL++ A DNG + + + E+D
Sbjct: 1315 SAAGEYD--ILSIKAVDNGRPQKSSTTRLHIEWISKPKQSLEPISFEESFFTFTVMESDP 1372
Query: 1168 LSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLP---QRKNQ 1224
+++ MI V P+ + + + G G I+ + P ++K+
Sbjct: 1373 VAH-------MIGVISVE-PPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSN 1424
Query: 1225 QNLGLPSLSSTAILMVTVADVPDEVEMSD-KPVFISRYYELEIEENVNAPVELVSLNLTE 1283
NL + + T ++ V ++ +D +P F + YE+ I E+ E++ ++ +
Sbjct: 1425 YNLTVEATDGTTTILTQV--FIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVD 1482
Query: 1284 HYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRE 1343
E K+ Y + + D + F +DP G+LY D E + V Q
Sbjct: 1483 QDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVSPAHLTVMVRDQD---- 1538
Query: 1344 LPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
PV + ++VV + D ND++P FT
Sbjct: 1539 -----VPVKRNF--------ARIVVNVSDTNDHAPWFT 1563
Score = 77.4 bits (182), Expect = 4e-13
Identities = 122/486 (25%), Positives = 201/486 (41%), Gaps = 55/486 (11%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L SF+ + + + D NDN P Y M+++ K +V+ +++A DPD N ++Y
Sbjct: 1119 LSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV-QIEAFDPDSSSNDKLMYK 1177
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLAVV 555
+ TS F I+P TG ++ + + H L V +D N S + ++A V
Sbjct: 1178 I--TSG-NPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTD---NGSPPKSTIARV 1231
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV---------NDAFEQNDV 606
+++ NKP F+ Y+ + R D ++
Sbjct: 1232 IVKIL-DENDNKPQ---FLQKFYKIRLPEREKPDRERNARREPLYRVIATDKDEGPNAEI 1287
Query: 607 SYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRP-MYDFEAVALQENANLSIVTNATVH 665
SY + G E G F +E ++GV++ R++ YD ++ +N + +H
Sbjct: 1288 SYSIEDGNEHG-KFFIEPKTGVVSS----KRFSAAGEYDILSIKAVDNGRPQKSSTTRLH 1342
Query: 666 VVDVNDERGVL--LKGAHSPIIFHVKENSAGA-AIGQIFHTNMSSIYGNGTGNVRFLIAN 722
+ ++ + L + S F V E+ A IG I S+ G +
Sbjct: 1343 IEWISKPKQSLEPISFEESFFTFTVMESDPVAHMIGVI------SVEPPGIPLWFDITGG 1396
Query: 723 QQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEND 782
D D+ GTI KPLD E++ Y +TV A I + QV I + D ND
Sbjct: 1397 NYDSHFDVDKGT-GTIIVAKPLDAEQKSNYNLTVEATDGTTTI----LTQVFIKVIDTND 1451
Query: 783 NPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGE----GKEMFD 838
+ P F + YE I E++ TEI I A D DE N L +YTL + F
Sbjct: 1452 HRPQFSTSKYEVVIPEDTAPETEILQ---ISAVDQDE-KNKL-IYTLQSSRDPLSLKKFR 1506
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVAR--DTGGLSSEAELIIMIGDENDNKPEFNQI 896
+D TG + + + LD E L+++ R D + A +++ + D ND+ P F
Sbjct: 1507 LDPATGSL-YTSEKLDHEAVSPAHLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTAS 1565
Query: 897 EENSKV 902
+V
Sbjct: 1566 SYKGRV 1571
Score = 76.6 bits (180), Expect = 6e-13
Identities = 52/151 (34%), Positives = 78/151 (51%), Gaps = 13/151 (8%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I A D D L Y++ SGN + FS+ G L LD E Q + +L+V
Sbjct: 1161 IEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTG-LITTTSRKLDRE---QQDEHILEVT 1216
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVE-NLPN------GFSVLQVMA 330
+ +P K+ ARV +++LD NDN P+F FY I + E P+ + +V+A
Sbjct: 1217 VTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYRVIA 1276
Query: 331 TDKDQGENGEFTYQLDD--PKGAFSIDPRSG 359
TDKD+G N E +Y ++D G F I+P++G
Sbjct: 1277 TDKDEGPNAEISYSIEDGNEHGKFFIEPKTG 1307
Score = 75.8 bits (178), Expect = 1e-12
Identities = 114/474 (24%), Positives = 189/474 (39%), Gaps = 62/474 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ E+ P+G+ ++ ++A D D+G +G+IRY + V F I E G
Sbjct: 1043 VKEDAPVGSLVMTVSAHDEDAGRDGEIRYSIRD----------GSGVGV---FKIGEETG 1089
Query: 1000 HVIVARSLPPES--EFRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+ + L ES + L + A D G L+ I + + V+DVND+ P + Y +
Sbjct: 1090 VIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIM 1149
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG-ELDRETED 1114
E + +++A D D N L Y I + F I P TG+++ +LDRE +D
Sbjct: 1150 ENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQD 1209
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF-YAFDELLEWKHPEADELSNHNF 1173
++IL V DNG D NDN P+F F ++ + + D N
Sbjct: 1210 EHILEVTVTDNG-SPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARR 1268
Query: 1174 ESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLIL---------YSLPQRKNQ 1224
E + + NA I ++ + FI G++ Y + K
Sbjct: 1269 EPLYRVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDILSIKAV 1328
Query: 1225 QNLGLPSLSSTAILMVTVADVPDEVEMSDKPV-FISRYYELEIEENVNAPVELVSLNLTE 1283
N G P SST L + P + S +P+ F ++ + E + PV + ++
Sbjct: 1329 DN-GRPQKSSTTRLHIEWISKP---KQSLEPISFEESFFTFTVME--SDPVAHMIGVISV 1382
Query: 1284 HYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRE 1343
+ + I N F +D GT+ + + D E K Y + V A
Sbjct: 1383 EPPGIPLWFDITGGN---YDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEA-------- 1431
Query: 1344 LPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIP-TTAP 1396
+G T +V +++ D ND+ P+F+ +V IP TAP
Sbjct: 1432 ------------TDGTTTILTQVFIKVIDTNDHRPQFSTSKYEVV--IPEDTAP 1471
Score = 75.8 bits (178), Expect = 1e-12
Identities = 106/478 (22%), Positives = 193/478 (40%), Gaps = 39/478 (8%)
Query: 436 DEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMV 495
D + +V++ + ++ +++ F ++Y +K N+ + + A+ + N +
Sbjct: 1959 DGRFAGLTSVKINVKESKESHLKFT-QDVYSAVVKENSTEAETLAVITAIGSPI--NEPL 2015
Query: 496 LYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVV 555
Y + L FKI+ +G +S +P + EA D E AV
Sbjct: 2016 FYHI-----LNPDRRFKISRTSGVLSTTGTPFDREQQ----EAFDVVVEVIEEHKPSAVA 2066
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHG 613
+ V + + P F+ PY V + +G + + D+ +V Y L
Sbjct: 2067 HVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEH 2126
Query: 614 YEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDER 673
+E + E S + +L N+ V ++ N + V + +N
Sbjct: 2127 HEHFQIGPLGEIS--LKKQFELDTLNKEY--LVTVVAKDGGNPAFSAEVIVPITVMNKAM 2182
Query: 674 GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIA 733
V K +S I + + + H +S G V + I + +
Sbjct: 2183 PVFEKPFYSAEIAESIQVHS-----PVVHVQANSPEGL---KVFYSITDGDPFSQFTINF 2234
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQ-VTIYIEDENDNPPVFEHATY 792
G I PLD E Y++++ A + ++GA V I ++D NDNPPVF +Y
Sbjct: 2235 NTGVINVIAPLDFEAHPAYKLSIRATDS---LTGAHAEVFVDIIVDDINDNPPVFAQQSY 2291
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEMFDVDENTGVVKFI 849
+ E S IGT + ++ATD+D N Y +FG + + F VD +TG++ +
Sbjct: 2292 AVTLSEASVIGTSVVQ---VRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLL 2348
Query: 850 GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIH 905
+LD E+ + + + A D G LSS+ + + + D N N P F Q +++ H
Sbjct: 2349 -RTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNGNPPLFEQQIYEARISEH 2405
Score = 75.4 bits (177), Expect = 1e-12
Identities = 122/487 (25%), Positives = 198/487 (40%), Gaps = 89/487 (18%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ E++P GT I+ L A D D G +GQ+RY D E F +++ G
Sbjct: 936 VREDLPEGTVIMWLEAHDPDLGQSGQVRYSL------------LDHGEGN--FDVDKLSG 981
Query: 1000 HVIVARSLPPESE--FRLNISALDGG---NLNDNISVRVFVKDVND--HFPVFKKTWYNF 1052
V + + L E + + L + A D G +L+ V V V DVN+ H PVF
Sbjct: 982 AVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKG 1041
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRET 1112
V+E ++ V A D D G++ + Y I+ F+I TGV+ + LDRE+
Sbjct: 1042 TVKEDAPVGSLVMTVSAHDEDAGRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRES 1101
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHN 1172
Y LTV A D G DVNDN+ P+ E
Sbjct: 1102 TSHYWLTVFATDQGVVPLSSFIEIYIEVE-DVNDNA--------------PQTSE----- 1141
Query: 1173 FESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSL 1232
PVY I EN+P +V ++ A D D + N ++Y + Q G S+
Sbjct: 1142 -------PVYYPEIMENSPKDVSVVQIEAFDPD--SSSNDKLMYKITSGNPQ---GFFSI 1189
Query: 1233 SSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENFKMRY 1292
L+ T + D E D+ + E+ + +N + P ++ + +
Sbjct: 1190 HPKTGLITTTSRKLDR-EQQDEHIL-----EVTVTDNGSPPKSTIARVIVK--------- 1234
Query: 1293 YILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVA 1352
IL+END + F+ Y +R P+RE + +R++ +R P + +A
Sbjct: 1235 -ILDENDN--KPQFL-----QKFYKIRLPERE---------KPDRERNARREP-LYRVIA 1276
Query: 1353 EDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQLKGAIGHHP 1412
D EG + ++ I+D N++ F +V++ +A Y ++ +K P
Sbjct: 1277 TDKDEGP---NAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDILSIKAVDNGRP 1333
Query: 1413 TASRTVR 1419
S T R
Sbjct: 1334 QKSSTTR 1340
Score = 74.9 bits (176), Expect = 2e-12
Identities = 112/473 (23%), Positives = 196/473 (41%), Gaps = 49/473 (10%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGK-------VKAVDPDLGQ 491
L + V V L D NDN PVF+ + Y + +A + +V+ ++A D D
Sbjct: 1748 LSTNTTVLVHLQDENDNAPVFMQAE-YTGLISESASINSVVLTDRNVPLVIRAADADKDS 1806
Query: 492 NGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALF--VEASDQPANPSERR 549
N +++Y + S + + F I+ +TG + S E V+ D
Sbjct: 1807 NALLVYHIVEPS---VHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAE 1863
Query: 550 YSLAVVTIEVTRGTKGNKPDIPDFMGAP-YEFWVGSNVGIGTSVGQIRVNDAFEQ--NDV 606
Y+ A VT+ V + D P P YE + G V + DA + +
Sbjct: 1864 YA-ANVTVHVI-----DINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQL 1917
Query: 607 SYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHV 666
Y + G G F+++ ++G +TV + +R +E + + +T+ ++V
Sbjct: 1918 IYSITEG-NIGEKFSMDYKTGALTVQNTTQLRSR----YELTVRASDGRFAGLTSVKINV 1972
Query: 667 VDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDV 726
+ + + +S + VKENS A + + G+ F D
Sbjct: 1973 KESKESHLKFTQDVYSAV---VKENSTEAETLAVI-----TAIGSPINEPLFYHILNPDR 2024
Query: 727 TDDIAIAEDGTIFTQKPLDREKRDVYRMTV-IAEFNKGVISGAGIYQVTIYIEDENDNPP 785
I+ T P DRE+++ + + V + E +K S V + +ED+NDN P
Sbjct: 2025 RFKISRTSGVLSTTGTPFDREQQEAFDVVVEVIEEHKP--SAVAHVVVKVIVEDQNDNAP 2082
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDV---DEN 842
VF + Y + ++++G I+ + A D D G N Y L E E F + E
Sbjct: 2083 VFVNLPYYAVVKVDTEVGHVIR---YVTAVDRDSGRNGEVHYYL-KEHHEHFQIGPLGEI 2138
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQ 895
+ +F D+L++E Y +++VA+D G + AE+I+ I N P F +
Sbjct: 2139 SLKKQFELDTLNKE----YLVTVVAKDGGNPAFSAEVIVPITVMNKAMPVFEK 2187
Score = 74.9 bits (176), Expect = 2e-12
Identities = 108/436 (24%), Positives = 180/436 (41%), Gaps = 56/436 (12%)
Query: 990 RYFVINERHGHVIVAR----SLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVF 1045
++FVI+ G + ++ +L P + LN+S DG + V V V N H P F
Sbjct: 2439 KHFVIDSATGIITLSNLHRHALKPF--YSLNLSVSDGV-FRSSTQVHVTVIGGNLHSPAF 2495
Query: 1046 KKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVN 1105
+ Y + E ++ +V TD D G ++TY I F I+ + ++
Sbjct: 2496 LQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLE 2555
Query: 1106 GELDRETEDKYILTV--VARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHP 1163
+LDRET + +++V +A+D G D NDN+P+F A +
Sbjct: 2556 -KLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILT---DDNDNAPQFRATKYEVNIGSS 2611
Query: 1164 EA----------DELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGL 1213
A D N + I +++EN I ++ V IG N
Sbjct: 2612 AAKGTSVVKSASDADEGSNADITYAIEADSESVKENLEINK-LSGVITTKESLIGLENEF 2670
Query: 1214 ILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAP 1273
+ + N G PS S ++ V + +P E+++ P F +Y + E+V
Sbjct: 2671 FTFFVRAVDN----GSPSKESVVLVYVKI--LPPEMQL---PKFSEPFYTFTVSEDVPVG 2721
Query: 1274 VELVSLNLTEHYENFKMRYYILNENDTDIRR--TFVIDPRNGTLYLVRSPDREVKDTYEV 1331
E + L EH + + Y ++ N + R +FVID ++G L L +S D E Y+
Sbjct: 2722 TE-IDLIRAEH--SGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQF 2778
Query: 1332 IVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAI 1391
+ A + E+ VA V V +++KD NDNSP F + P I
Sbjct: 2779 SILARCTQDDHEM------VA----------SVDVSIQVKDANDNSPVFESS--PYEAFI 2820
Query: 1392 PTTAPFGYQVMQLKGA 1407
P G +V+Q++ +
Sbjct: 2821 VENLPGGSRVIQIRAS 2836
Score = 72.9 bits (171), Expect = 8e-12
Identities = 48/180 (26%), Positives = 83/180 (46%), Gaps = 8/180 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D+D G +RY + G+ +F + G + LD ++ + F
Sbjct: 1056 VSAHDEDAGRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQG 1115
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
L++ ++ + IE+ D+NDN P+ Y I+EN P SV+Q+ A D D
Sbjct: 1116 VVPLSSFIE-----IYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSS 1170
Query: 338 NGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
N + Y++ +P+G FSI P++G +T ++ LDRE ++V + T A
Sbjct: 1171 NDKLMYKITSGNPQGFFSIHPKTGLITTTSRK-LDREQQDEHILEVTVTDNGSPPKSTIA 1229
Score = 71.7 bits (168), Expect = 2e-11
Identities = 102/406 (25%), Positives = 169/406 (41%), Gaps = 58/406 (14%)
Query: 946 IGTTIIKLNALDLDSGLNGQIRY---EFNSEVYIPPSKLSADALEVKRYFVINERHGHVI 1002
+G I + A+D DSG NG++ Y E + I P + +K+ F ++ +
Sbjct: 2099 VGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQIGP----LGEISLKKQFELDTLN---- 2150
Query: 1003 VARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRR 1062
E+ + + A DGGN + V V + +N PVF+K +Y+ + E+ +
Sbjct: 2151 --------KEYLVTVVAKDGGNPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESI---Q 2199
Query: 1063 VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVA 1122
V V A+ + + Y I D F I+ TGV++V LD E Y L++ A
Sbjct: 2200 VHSPVVHVQANSPEGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRA 2259
Query: 1123 RDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVY 1182
D+ D+NDN P F + A LS + ++ V
Sbjct: 2260 TDS--LTGAHAEVFVDIIVDDINDNPPVFA--------QQSYAVTLSEASVIGTSVVQV- 2308
Query: 1183 KATIEENAPIGTTVAKVFAN-----DTDFIGNGNGLI--LYSLPQRKNQQNL-------- 1227
+AT ++ P ++F N D + + GLI L +L +++Q+
Sbjct: 2309 RATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDG 2368
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEHY 1285
G+P+LSS I+ V V D+ + P+F + YE I E+ V V +
Sbjct: 2369 GMPTLSSDVIVTVDVTDL-----NGNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSS 2423
Query: 1286 ENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEV 1331
+ K++Y IL+ ND + FVID G + L +K Y +
Sbjct: 2424 DIDKLQYSILSGND---HKHFVIDSATGIITLSNLHRHALKPFYSL 2466
Score = 71.3 bits (167), Expect = 2e-11
Identities = 126/552 (22%), Positives = 229/552 (41%), Gaps = 82/552 (14%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
GT+++K +A D D G N I Y + AD+ VK IN+ G + S
Sbjct: 2615 GTSVVK-SASDADEGSNADITYA-----------IEADSESVKENLEINKLSGVITTKES 2662
Query: 1007 LPP-ESEF-RLNISALDGGNLNDNISVRVFVKDVNDHF--PVFKKTWYNFNVEEAQYTRR 1062
L E+EF + A+D G+ + V V+VK + P F + +Y F V E
Sbjct: 2663 LIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPVGT 2722
Query: 1063 VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVA 1122
+ + A + + + S+ D F I +G L + LD ET Y +++A
Sbjct: 2723 EIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILA 2782
Query: 1123 RDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVY 1182
R D NDNSP FES Y
Sbjct: 2783 RCTQDDHEMVASVDVSIQVKDANDNSPV----------------------FES----SPY 2816
Query: 1183 KATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTV 1242
+A I EN P G+ V ++ A+D D NG ++YSL Q ++ + + +++ + T+
Sbjct: 2817 EAFIVENLPGGSRVIQIRASDAD--SGTNGQVMYSLDQSQSVEVIESFAINMETGWITTL 2874
Query: 1243 ADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDI 1302
++ E + + ++ + +I+ + A V++ ++ + F Y ++ D
Sbjct: 2875 KELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDD- 2933
Query: 1303 RRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIY---PVAEDVLEGM 1359
P+ G + ++ + D A+ ++ +R++ + I P+ + +E +
Sbjct: 2934 -------PQGGVIAILSTTD------------ADSEEINRQVTYFITGGDPLGQFAVETI 2974
Query: 1360 TKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQ-VMQLK--GAIGHHPTASR 1416
+ KV V K D + + L+T T F + ++++K A + P +
Sbjct: 2975 QN-EWKVYV--KKPLDREKR----DNYLLTITATDGTFSSKAIVEVKVLDANDNSPVCEK 3027
Query: 1417 TVRADT-DELVFFERLSLNGLTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRV 1475
T+ +DT E V +L + ATD+DI NA+I Y +L A +F ++P +G ++
Sbjct: 3028 TLYSDTIPEDVLPGKL----IMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKT 3083
Query: 1476 VAALARDAGRVF 1487
L R+ V+
Sbjct: 3084 STPLDREEQAVY 3095
Score = 69.3 bits (162), Expect = 1e-10
Identities = 56/179 (31%), Positives = 80/179 (44%), Gaps = 15/179 (8%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR---KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
I A+DQD L Y L S D K F LD GSL+ ++LD +A + L
Sbjct: 1478 ISAVDQD--EKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEA-----VSPAHL 1530
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
V + P+K AR+ + + D ND+ P F Y + E+ G VLQV A DKD
Sbjct: 1531 TVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKD 1590
Query: 335 QGENGEFTYQLDDPK-----GAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
+G+N E Y ++ +F IDP G + + +A L +K K + P
Sbjct: 1591 KGKNAEVLYSIESGNIGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPP 1649
Score = 67.7 bits (158), Expect = 3e-10
Identities = 93/365 (25%), Positives = 151/365 (41%), Gaps = 45/365 (12%)
Query: 991 YFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVK--DVNDHFPVFK 1046
+F +++ G +IVA+ L E S + L + A DG I +VF+K D NDH P F
Sbjct: 1401 HFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDG---TTTILTQVFIKVIDTNDHRPQFS 1457
Query: 1047 KTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDL---PFEISPLTGVLS 1103
+ Y + E + ++ A D D + L Y +Q S L F + P TG L
Sbjct: 1458 TSKYEVVIPEDTAPETEILQISAVDQD--EKNKLIYTLQSSRDPLSLKKFRLDPATGSLY 1515
Query: 1104 VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHP 1163
+ +LD E LTV+ RD D ND++P F
Sbjct: 1516 TSEKLDHEAVSPAHLTVMVRDQ-DVPVKRNFARIVVNVSDTNDHAPWF------------ 1562
Query: 1164 EADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGN-GNGL----ILYSL 1218
A +ES + V + G +++ ++ IGN GN +L S+
Sbjct: 1563 TASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNIGNSFMIDPVLGSI 1622
Query: 1219 P-----QRKNQ--QNLGLPSLSSTAILMVTVADVPDEVEMSD--KPVFISRYYELEIEEN 1269
R NQ +L + + + M + V V ++D P F S+ Y +E+ E
Sbjct: 1623 KTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSET 1682
Query: 1270 VNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTY 1329
V+ V + +T H ++ + Y I + N D F I+P +GT+ ++ D E Y
Sbjct: 1683 VSIG-SFVGM-VTAHSQS-SVVYEIKDGNTGD---AFDINPHSGTIITQKALDFETLPIY 1736
Query: 1330 EVIVR 1334
+I++
Sbjct: 1737 TLIIQ 1741
Score = 67.7 bits (158), Expect = 3e-10
Identities = 55/193 (28%), Positives = 86/193 (44%), Gaps = 21/193 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN P+ T ++++ D DSG+ G + Y ++ K F INER G
Sbjct: 2504 LAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDF-------------AKDRFYINER-G 2549
Query: 1000 HVIVARSL----PPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+ L P E + + A D G +V V + D ND+ P F+ T Y N+
Sbjct: 2550 QIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIG 2609
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP--FEISPLTGVLSVNGELDRETE 1113
+ + K A+DAD G NA++TY I+ + EI+ L+GV++ L
Sbjct: 2610 SSAAKGTSVVK-SASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLEN 2668
Query: 1114 DKYILTVVARDNG 1126
+ + V A DNG
Sbjct: 2669 EFFTFFVRAVDNG 2681
Score = 67.3 bits (157), Expect = 4e-10
Identities = 47/168 (27%), Positives = 79/168 (47%), Gaps = 8/168 (4%)
Query: 231 LRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANT-----FVLQVQASQLNNPL 285
+RY+++SG+ LF + F + + N + L V+A + N +
Sbjct: 70 VRYKIVSGDSENLFKAEEYILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNV 129
Query: 286 KTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+ A+ +V +++LD ND P F Y++S+ EN S+ +V ATD D G NGEF Y
Sbjct: 130 E-ARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSF 188
Query: 346 DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
D F+I P SG + + + LD M++ A + + G+
Sbjct: 189 KDRTDMFAIHPTSGVIVLTGR--LDYLETKLYEMEILAADRGMKLYGS 234
Score = 64.9 bits (151), Expect = 2e-09
Identities = 54/190 (28%), Positives = 88/190 (46%), Gaps = 15/190 (7%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V +L AN N P F + Y+ + N +GT I + AVDPD G+NG V Y + ++
Sbjct: 449 VLVKVLGANSNPPEFTQT-AYKAAFDENVPIGTTIMSLSAVDPDEGENGYVTYSIANLNH 507
Query: 505 LTITSPFKINPNTGTVSVAES---PILEGRHALFVEASDQPANPSERRYSLAVVTIEVTR 561
+ PF I+ TG VS +E+ ++ + L + ASD LA +T+
Sbjct: 508 V----PFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITL---- 559
Query: 562 GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFA 621
+ P F E + ++G+G + + DA E V Y + G E + F+
Sbjct: 560 --NNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDL-FS 616
Query: 622 VEERSGVITV 631
+ SGV+++
Sbjct: 617 LNPNSGVLSL 626
Score = 64.5 bits (150), Expect = 3e-09
Identities = 46/159 (28%), Positives = 72/159 (45%), Gaps = 9/159 (5%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A D D A L Y ++ + F++DS G++ LD + + + F
Sbjct: 1794 PLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYE-----ETSIFHF 1848
Query: 275 QVQASQLNNPLKTAQ--ARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
VQ + P A+ A V + ++D+ND P F Y S++ G V+ V ATD
Sbjct: 1849 TVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATD 1908
Query: 333 KDQGENGEFTYQLDDPK--GAFSIDPRSGWLTVRNQTVL 369
D + Y + + FS+D ++G LTV+N T L
Sbjct: 1909 ADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTTQL 1947
Score = 64.1 bits (149), Expect = 4e-09
Identities = 40/118 (33%), Positives = 59/118 (50%), Gaps = 3/118 (2%)
Query: 1010 ESEFRLNISALDGG-NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVD 1068
+ + L + AL+ N+ VRV V D ND P+F T Y+ ++ E R + +V
Sbjct: 113 KDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVS 172
Query: 1069 ATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
ATDAD G N Y+ TD+ F I P +GV+ + G LD Y + ++A D G
Sbjct: 173 ATDADIGTNGEF-YYSFKDRTDM-FAIHPTSGVIVLTGRLDYLETKLYEMEILAADRG 228
Score = 62.5 bits (145), Expect = 1e-08
Identities = 48/171 (28%), Positives = 81/171 (47%), Gaps = 13/171 (7%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G L +++ GN F +D G++ + K LD + + N + L V+A+ + T
Sbjct: 1386 GIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSN-----YNLTVEATDGTTTILT 1440
Query: 288 AQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD- 346
+V I+++D ND+ P+F Y + I E+ +LQ+ A D+D+ +T Q
Sbjct: 1441 ---QVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSR 1497
Query: 347 DPKG--AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
DP F +DP +G L + LD EA S + V ++ + V FA
Sbjct: 1498 DPLSLKKFRLDPATGSLYTSEK--LDHEAVSPAHLTVMVRDQDVPVKRNFA 1546
Score = 62.5 bits (145), Expect = 1e-08
Identities = 114/473 (24%), Positives = 183/473 (38%), Gaps = 59/473 (12%)
Query: 939 LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERH 998
+IPE+ T I++++A+D D E N +Y S S D L +K+ F ++
Sbjct: 1464 VIPEDTAPETEILQISAVDQD---------EKNKLIYTLQS--SRDPLSLKK-FRLDPAT 1511
Query: 999 GHVIVARSLPPE--SEFRLNISALDGG-NLNDNIS-VRVFVKDVNDHFPVFKKTWYNFNV 1054
G + + L E S L + D + N + + V V D NDH P F + Y V
Sbjct: 1512 GSLYTSEKLDHEAVSPAHLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRV 1571
Query: 1055 EEAQYTRRVLGKVDATDADFGQNANLTYFIQP---SDTDLPFEISPLTGVLSVNGELDRE 1111
E+ V+ +V A D D G+NA + Y I+ + F I P+ G + ELDR
Sbjct: 1572 YESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNIGNSFMIDPVLGSIKTAKELDRS 1631
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDN-SPKFYAFDELLEWKHPEADELSN 1170
+ +Y L V A D G + DN SPKF + + +E ++ +S
Sbjct: 1632 NQAEYDLMVKATDKGSPPMSEITSVRIFVT--IADNASPKFTSKEYSVEL----SETVSI 1685
Query: 1171 HNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLP-QRKNQQNLGL 1229
+F ++ + + E T A + I L +LP Q +
Sbjct: 1686 GSFVGMVTAHSQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNM 1745
Query: 1230 PSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNA-PVELVSLNL------- 1281
LS+ ++V + D E + PVF+ Y I E+ + V L N+
Sbjct: 1746 AGLSTNTTVLVHLQD-----ENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAA 1800
Query: 1282 -TEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKY 1340
+ N + Y+I+ + + F ID G ++ V S D E + V Q +
Sbjct: 1801 DADKDSNALLVYHIV---EPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTV----QVH 1853
Query: 1341 SRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPT 1393
P + +Y V V + D+ND P F +PT
Sbjct: 1854 DMGTPRL-----------FAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPT 1895
Score = 60.5 bits (140), Expect = 5e-08
Identities = 65/277 (23%), Positives = 125/277 (45%), Gaps = 27/277 (9%)
Query: 79 AYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKA-FIFLI-APIGPSLTIPLTVPR 136
A++ V V +ED NDN P+F++ PY+ V T G ++ + G + + +
Sbjct: 2066 AHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKE 2125
Query: 137 GLTIFK-----DIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSH-KPVLLLRKVLDY 190
F+ +I + + +T N + ++V+ D G+ A + P+ ++ K +
Sbjct: 2126 HHEHFQIGPLGEISLKKQFELDTLNKEYLVTVVA-KDGGNPAFSAEVIVPITVMNKAMP- 2183
Query: 191 DAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVN 250
+K F +A ++H P+ + + G + Y + G+ F+++
Sbjct: 2184 -VFEKPFYSAEIAESIQVHS------PVVHVQANSPEGLKVFYSITDGDPFSQFTINFNT 2236
Query: 251 GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELL--DLNDNLPEFEV 308
G + + LD +A + L ++A+ + L A A V ++++ D+NDN P F
Sbjct: 2237 GVINVIAPLDFEAHP-----AYKLSIRAT---DSLTGAHAEVFVDIIVDDINDNPPVFAQ 2288
Query: 309 DFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
Y +++ E G SV+QV ATD D N +YQ+
Sbjct: 2289 QSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQM 2325
Score = 60.5 bits (140), Expect = 5e-08
Identities = 77/333 (23%), Positives = 135/333 (40%), Gaps = 68/333 (20%)
Query: 70 IGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLT 129
+ G+ +S+ + VTV + D+N N P+F Y + E P G F+
Sbjct: 2366 VDGGMPTLSSDVIVTVDVTDLNGNPPLFEQQIYEARISEHAPHGH----FVTC------- 2414
Query: 130 IPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESS---------HKP 180
++A+D D + + YSI+SGND HF ++S+ H+
Sbjct: 2415 --------------VKAYDADSSDIDK--LQYSILSGNDHKHFVIDSATGIITLSNLHRH 2458
Query: 181 VLLLRKVLDYDAGDKEF----QLVIMASGKRIHK----------EILFPEPIHAI----- 221
L L+ D F Q+ + G +H E+ P+H +
Sbjct: 2459 ALKPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVK 2518
Query: 222 --DQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
D D G+ + Y +++ + F ++ G +F ++LD + V+ V+
Sbjct: 2519 TTDGDSGIYGHVTYHIVNDFAKDRFYINE-RGQIFTLEKLDRETPAEK-----VISVRLM 2572
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
+ K A V + L D NDN P+F Y ++I + G SV++ A+D D+G N
Sbjct: 2573 AKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVK-SASDADEGSNA 2631
Query: 340 EFTYQL----DDPKGAFSIDPRSGWLTVRNQTV 368
+ TY + + K I+ SG +T + +
Sbjct: 2632 DITYAIEADSESVKENLEINKLSGVITTKESLI 2664
Score = 59.3 bits (137), Expect = 1e-07
Identities = 99/452 (21%), Positives = 183/452 (40%), Gaps = 45/452 (9%)
Query: 457 PVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPN 516
P+ + + F++ + V +IG + P + + +D+ + S F ++
Sbjct: 1355 PISFEESFFTFTVMESDPVAHMIGVISVEPPGIP----LWFDI---TGGNYDSHFDVDKG 1407
Query: 517 TGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIPDFM 574
TGT+ VA+ E + + L VEA+D L V I+V T ++P F
Sbjct: 1408 TGTIIVAKPLDAEQKSNYNLTVEATDGTTT------ILTQVFIKVI-DTNDHRPQ---FS 1457
Query: 575 GAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE--EGVPFAVEERSGVITVV 632
+ YE + + T + QI D E+N + Y L + F ++ +G +
Sbjct: 1458 TSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTS 1517
Query: 633 DDLSRYN-RPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKEN 691
+ L P + V Q+ V+V D ND ++ ++ +
Sbjct: 1518 EKLDHEAVSPAHLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVY--ESA 1575
Query: 692 SAGAAIGQIFHT------NMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLD 745
+ G+ + Q+ N +Y +GN+ + + D + G+I T K LD
Sbjct: 1576 AVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNI--GNSFMIDPVL----GSIKTAKELD 1629
Query: 746 REKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTE 805
R + Y + V A +KG + I V I++ ++ P F Y + E IG+
Sbjct: 1630 RSNQAEYDLMVKAT-DKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSF 1688
Query: 806 IKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSL 865
+ M A ++ ++ G + FD++ ++G + +LD E +Y L +
Sbjct: 1689 VGM------VTAHSQSSVVYEIK-DGNTGDAFDINPHSGTI-ITQKALDFETLPIYTLII 1740
Query: 866 VARDTGGLSSEAELIIMIGDENDNKPEFNQIE 897
+ GLS+ +++ + DENDN P F Q E
Sbjct: 1741 QGTNMAGLSTNTTVLVHLQDENDNAPVFMQAE 1772
Score = 56.0 bits (129), Expect = 1e-06
Identities = 50/177 (28%), Positives = 80/177 (45%), Gaps = 15/177 (8%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D L+Y ++SGND K F +DS G + L H L+ + L +
Sbjct: 2415 VKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNL----HRHALKP-FYSLNLS 2469
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
S + + + +V + ++ N + P F + Y + + EN P V++V TD D G
Sbjct: 2470 VS---DGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGI 2526
Query: 338 NGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDRE--AHSSLRMKVYAKETNPSV 390
G TY + D K F I+ R T+ LDRE A + +++ AK+ V
Sbjct: 2527 YGHVTYHIVNDFAKDRFYINERGQIFTLEK---LDRETPAEKVISVRLMAKDAGGKV 2580
Score = 54.8 bits (126), Expect = 2e-06
Identities = 34/100 (34%), Positives = 56/100 (56%), Gaps = 4/100 (4%)
Query: 1028 NISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
++ V+V V+D ND+ PVF Y V+ V+ V A D D G+N + Y+++
Sbjct: 2067 HVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEH 2126
Query: 1088 DTDLPFEISPLTGVLSVNGELDRETEDK-YILTVVARDNG 1126
F+I PL G +S+ + + +T +K Y++TVVA+D G
Sbjct: 2127 HEH--FQIGPL-GEISLKKQFELDTLNKEYLVTVVAKDGG 2163
Score = 54.4 bits (125), Expect = 3e-06
Identities = 44/153 (28%), Positives = 68/153 (44%), Gaps = 11/153 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKL--FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A D D + Y++ + + F +DS G + L + LD E + Q FV
Sbjct: 2308 VRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDY--EQSRQHTIFVRA 2365
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
V P ++ V +++ DLN N P FE Y I E+ P+G V V A D D
Sbjct: 2366 VDGGM---PTLSSDVIVTVDVTDLNGNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADS 2422
Query: 336 GENGEFTYQL---DDPKGAFSIDPRSGWLTVRN 365
+ + Y + +D K F ID +G +T+ N
Sbjct: 2423 SDIDKLQYSILSGNDHK-HFVIDSATGIITLSN 2454
Score = 53.6 bits (123), Expect = 5e-06
Identities = 40/130 (30%), Positives = 62/130 (47%), Gaps = 11/130 (8%)
Query: 231 LRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQA 290
LRY + FSL+ G + + L+ QA F L+V S + A
Sbjct: 398 LRYVFKRTPGKAKFSLNYNTGLISI-----LEPVKRQQAAHFELEVTTSD-----RKAST 447
Query: 291 RVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKG 350
+V +++L N N PEF Y + EN+P G +++ + A D D+GENG TY + +
Sbjct: 448 KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTIMSLSAVDPDEGENGYVTYSIANLNH 507
Query: 351 A-FSIDPRSG 359
F+ID +G
Sbjct: 508 VPFAIDHFTG 517
Score = 50.8 bits (116), Expect = 4e-05
Identities = 94/487 (19%), Positives = 192/487 (39%), Gaps = 56/487 (11%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
+ +V + + A++ +P F S Y + +G+ +G V A V+Y+
Sbjct: 1650 MSEITSVRIFVTIADNASPKFT-SKEYSVELSETVSIGSFVGMVTA-----HSQSSVVYE 1703
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVT 556
++ + F INP++GT+ ++ E + L ++ ++ + V
Sbjct: 1704 IKDGNT---GDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLSTN-----TTVL 1755
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQ-------IRVNDAFEQNDVSYD 609
+ + + + P FM A Y + + I + V IR DA + ++
Sbjct: 1756 VHL----QDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALL- 1810
Query: 610 LLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSI----VTNAT 663
+ H E V FA++ +G I V L ++ F V + + + N T
Sbjct: 1811 VYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHF-TVQVHDMGTPRLFAEYAANVT 1869
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
VHV+D+ND V K + + ++ N + + + + I +
Sbjct: 1870 VHVIDINDCPPVFAKPLYEASLLLPTYKGV-----KVITVNATDADSSAFSQLIYSIT-E 1923
Query: 724 QDVTDDIAIA-EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEND 782
++ + ++ + G + Q R Y +TV A + AG+ V I +++ +
Sbjct: 1924 GNIGEKFSMDYKTGALTVQNTTQLRSR--YELTVRASDGRF----AGLTSVKINVKESKE 1977
Query: 783 NPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDEN 842
+ F Y + ENS TE + +I A + N Y + + F +
Sbjct: 1978 SHLKFTQDVYSAVVKENS---TEAETLAVITAIGSP--INEPLFYHILNPDRR-FKISRT 2031
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELII--MIGDENDNKPEFNQIEENS 900
+GV+ G DRE++ + + + + S+ A +++ ++ D+NDN P F + +
Sbjct: 2032 SGVLSTTGTPFDREQQEAFDVVVEVIEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYA 2091
Query: 901 KVRIHRE 907
V++ E
Sbjct: 2092 VVKVDTE 2098
Score = 50.0 bits (114), Expect = 6e-05
Identities = 26/76 (34%), Positives = 41/76 (53%), Gaps = 6/76 (7%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V +LD ND P+F P++ Y S+ N + T I +V A D D+G NG Y + ++
Sbjct: 135 VRVQVLDTNDLRPLFSPTS-YSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTD 193
Query: 505 LTITSPFKINPNTGTV 520
+ F I+P +G +
Sbjct: 194 M-----FAIHPTSGVI 204
Score = 50.0 bits (114), Expect = 6e-05
Identities = 45/161 (27%), Positives = 72/161 (44%), Gaps = 27/161 (16%)
Query: 1226 NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHY 1285
+LG+P ++ +L V V D D + P F+ Y +E+ E+ E++ + T+
Sbjct: 796 DLGIPQKAAWRLLHVVVVDAND-----NPPEFLQESYFVEVSEDKEVHSEIIQVEATDKD 850
Query: 1286 --ENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRE 1343
N + Y IL + DT F ID G + + R DRE++ + + + A Q +RE
Sbjct: 851 LGPNGHVTYSILTDTDT-----FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ--ARE 903
Query: 1344 LPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGN 1384
P + V V V ++DVNDN P F N
Sbjct: 904 EPQLFSTVV-------------VKVSLEDVNDNPPTFIPPN 931
Score = 49.2 bits (112), Expect = 1e-04
Identities = 89/358 (24%), Positives = 139/358 (38%), Gaps = 26/358 (7%)
Query: 25 RDLNRTHVSVILAQSIDSLVDSDSPQNVVKFRLGCDFDEGDDL---VRI-GAGLNQISAY 80
+D N V I+ S+ + DS + L D++E V++ G ++ A
Sbjct: 1804 KDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAE 1863
Query: 81 LS--VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS----LTIPLTV 134
+ VTV++ D+ND P+F Y ++ T G K S L +T
Sbjct: 1864 YAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITE 1923
Query: 135 PR-GLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
G D + NT Y + DG FA +S K + K ++
Sbjct: 1924 GNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLTSVKINVKESK----ESH 1979
Query: 194 DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSL 253
K Q V A K E I AI + L Y +++ + R F + +G L
Sbjct: 1980 LKFTQDVYSAVVKENSTEAETLAVITAIGSP--INEPLFYHILNPDRR--FKISRTSGVL 2035
Query: 254 FLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF-EVDFYN 312
D E Q F + V+ + + P A V++ + D NDN P F + +Y
Sbjct: 2036 STTGT-PFDRE---QQEAFDVVVEVIEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYA 2091
Query: 313 ISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLD 370
+ V+ G + V A D+D G NGE Y L + F I P G ++++ Q LD
Sbjct: 2092 VVKVDT-EVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQIGP-LGEISLKKQFELD 2147
Score = 49.2 bits (112), Expect = 1e-04
Identities = 43/169 (25%), Positives = 82/169 (48%), Gaps = 12/169 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D+D G + Y L ++ F + + G + L+K+ +LD + +++ V
Sbjct: 2106 VTAVDRDSGRNGEVHYYLKEHHEH--FQIGPL-GEISLKKQFELDTLNK----EYLVTVV 2158
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A NP +A+ V I ++ N +P FE FY+ I E++ V+ V A + +G
Sbjct: 2159 AKDGGNPAFSAEVIVPITVM--NKAMPVFEKPFYSAEIAESIQVHSPVVHVQA-NSPEGL 2215
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKET 386
++ DP F+I+ +G + V LD EAH + ++ + A ++
Sbjct: 2216 KVFYSITDGDPFSQFTINFNTGVINV--IAPLDFEAHPAYKLSIRATDS 2262
Score = 46.4 bits (105), Expect = 8e-04
Identities = 95/403 (23%), Positives = 151/403 (37%), Gaps = 55/403 (13%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G +I +NA D DS Q+ Y + F ++ + G + V +
Sbjct: 1898 GVKVITVNATDADSSAFSQLIYSITEG-------------NIGEKFSMDYKTGALTVQNT 1944
Query: 1007 LPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGK 1066
S + L + A DG SV++ VK+ + F + Y+ V+E L
Sbjct: 1945 TQLRSRYELTVRASDG-RFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAV 2003
Query: 1067 VDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG-ELDRETEDKYILTVVARDN 1125
+ A G N F + D F+IS +GVLS G DRE ++ + + V +
Sbjct: 2004 ITA----IGSPINEPLFYHILNPDRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEVIEE 2059
Query: 1126 GXXXXXXXXXXXXXXXXDVNDNSPKF-----YAFDEL-LEWKH-----PEADELSNHNFE 1174
D NDN+P F YA ++ E H D S N E
Sbjct: 2060 -HKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGE 2118
Query: 1175 SVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSS 1234
+ Y E+ IG + ++ + N L ++ + G P+ S+
Sbjct: 2119 ----VHYYLKEHHEHFQIG-PLGEISLKKQFELDTLNKEYLVTVVAKDG----GNPAFSA 2169
Query: 1235 TAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSLNLTEHYENFKMRY 1292
I+ +TV + PVF +Y EI E+ V++PV V N E K+ Y
Sbjct: 2170 EVIVPITVMN-------KAMPVFEKPFYSAEIAESIQVHSPVVHVQANSP---EGLKVFY 2219
Query: 1293 YILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
I D D F I+ G + ++ D E Y++ +RA
Sbjct: 2220 SI---TDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRA 2259
Score = 44.4 bits (100), Expect = 0.003
Identities = 59/244 (24%), Positives = 104/244 (42%), Gaps = 16/244 (6%)
Query: 635 LSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSA- 693
L+R + Y AL++N N+ T V V+D ND R + ++S + EN+A
Sbjct: 108 LNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYS---VSLPENTAI 164
Query: 694 GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVY 752
+I ++ T+ + I NG F +D TD AI G I LD + +Y
Sbjct: 165 RTSIARVSATD-ADIGTNGEFYYSF-----KDRTDMFAIHPTSGVIVLTGRLDYLETKLY 218
Query: 753 RMTVI-AEFNKGVISGAGI---YQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKM 808
M ++ A+ + +GI ++T++IE N+ PV T ++ + +
Sbjct: 219 EMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDPAYAIVTV 278
Query: 809 DNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGV-VKFIGDSLDREKKIMYKLSLVA 867
D+ + + D + ++ L + + + + VK IGD Y L+L A
Sbjct: 279 DDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGDIDWDSHPFGYNLTLQA 338
Query: 868 RDTG 871
+D G
Sbjct: 339 KDKG 342
Score = 40.7 bits (91), Expect = 0.039
Identities = 68/334 (20%), Positives = 126/334 (37%), Gaps = 24/334 (7%)
Query: 571 PDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVP-FAVEERSGVI 629
P F Y + N I TS+ ++ DA + + + +++ FA+ SGVI
Sbjct: 147 PLFSPTSYSVSLPENTAIRTSIARVSATDA--DIGTNGEFYYSFKDRTDMFAIHPTSGVI 204
Query: 630 TVVDDLSRYNRPMYDFEAVA------LQENANLSIVTNATVHVVDVNDERGVLLKGAHSP 683
+ L +Y+ E +A L ++ +S + TVH+ N+ V+ SP
Sbjct: 205 VLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSP 264
Query: 684 IIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKP 743
A + I V + Q +++ +
Sbjct: 265 SELDRDPAYAIVTVDDCDQGANGDI--ASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGD 322
Query: 744 LDREKRDV-YRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV-FEHATYEGFIMENSK 801
+D + Y +T+ A+ +KG +V + PV FE Y I E +
Sbjct: 323 IDWDSHPFGYNLTLQAK-DKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAP 381
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMY 861
T + M +KA A +F T GK F ++ NTG++ + + + R++ +
Sbjct: 382 PNTPVVM---VKAIPAYSHLRYVFKRT---PGKAKFSLNYNTGLISIL-EPVKRQQAAHF 434
Query: 862 KLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQ 895
+L + D + ++++ + N N PEF Q
Sbjct: 435 ELEVTTSDR---KASTKVLVKVLGANSNPPEFTQ 465
Score = 39.5 bits (88), Expect = 0.091
Identities = 18/52 (34%), Positives = 32/52 (61%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARDAGRVF 1487
LT QATD+D G+N I Y +++ +F+I+ +SG +++ L R+ V+
Sbjct: 3146 LTRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVY 3197
Score = 39.1 bits (87), Expect = 0.12
Identities = 26/80 (32%), Positives = 39/80 (48%), Gaps = 8/80 (10%)
Query: 899 NSKVRIHRETKLNGTAGFTIIEVKPKNKF-ALDVDQLGPLFL-------IPENIPIGTTI 950
N +V+ H + T +E + K + LD + L PLF +PEN I T+I
Sbjct: 109 NREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSI 168
Query: 951 IKLNALDLDSGLNGQIRYEF 970
+++A D D G NG+ Y F
Sbjct: 169 ARVSATDADIGTNGEFYYSF 188
Score = 39.1 bits (87), Expect = 0.12
Identities = 52/233 (22%), Positives = 86/233 (36%), Gaps = 21/233 (9%)
Query: 233 YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV 292
YE+ GN F ++ +G++ +K LD + L T ++Q N + V
Sbjct: 1702 YEIKDGNTGDAFDINPHSGTIITQKALDFE---TLPIYTLIIQ----GTNMAGLSTNTTV 1754
Query: 293 EIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQ-------VMATDKDQGENGEFTYQL 345
+ L D NDN P F Y I E+ VL + A D D+ N Y +
Sbjct: 1755 LVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHI 1814
Query: 346 DDPK--GAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKET-NPSVVGTFAD--SQRI 400
+P F+ID +G + LD E S V + P + +A + +
Sbjct: 1815 VEPSVHTYFAIDSSTG--AIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHV 1872
Query: 401 AKWRRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDAN 453
P PL + + + P G K + D +F + ++ + N
Sbjct: 1873 IDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGN 1925
Score = 37.1 bits (82), Expect = 0.48
Identities = 43/175 (24%), Positives = 73/175 (41%), Gaps = 14/175 (8%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
++A D D + L Y + GN + FS+D G+L ++ L + + L V+
Sbjct: 1904 VNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTTQLRSRYE-------LTVR 1956
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
AS T+ V+I + + ++ +F D Y+ + EN ++ + A E
Sbjct: 1957 ASDGRFAGLTS---VKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGSPINE 2013
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKV-YAKETNPSVV 391
Y + +P F I SG L+ T DRE + + V +E PS V
Sbjct: 2014 --PLFYHILNPDRRFKISRTSGVLSTTG-TPFDREQQEAFDVVVEVIEEHKPSAV 2065
Score = 36.7 bits (81), Expect = 0.64
Identities = 16/48 (33%), Positives = 28/48 (58%)
Query: 1440 QATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARDAGRVF 1487
+A D D+G + +RY +L+ F +D +SG VR+V L + +V+
Sbjct: 950 EAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLDFEKKQVY 997
Score = 36.3 bits (80), Expect = 0.85
Identities = 17/43 (39%), Positives = 25/43 (58%), Gaps = 1/43 (2%)
Query: 1440 QATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
+ATD D+G N + Y IL + F+ID V+G V + L R+
Sbjct: 845 EATDKDLGPNGHVTYSILTD-TDTFSIDSVTGVVNIARPLDRE 886
Score = 35.5 bits (78), Expect = 1.5
Identities = 13/41 (31%), Positives = 25/41 (60%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEK 115
+++ A + V++ ++D NDN P+F +PY + E P G +
Sbjct: 2789 HEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSR 2829
Score = 34.7 bits (76), Expect = 2.6
Identities = 40/176 (22%), Positives = 77/176 (43%), Gaps = 21/176 (11%)
Query: 220 AIDQDLGVGATLRYELISGND--RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
A D D G A + Y + + ++ ++ ++ ++G + ++ L L+ F V+
Sbjct: 2622 ASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLI-----GLENEFFTFFVR 2676
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A +P K + V +++L LP+F FY ++ E++P G + + A
Sbjct: 2677 AVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPVGTEIDLIRAE-----H 2731
Query: 338 NGEFTYQL---DDPKG----AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKET 386
+G Y L + P+ +F ID +SG L + LD E + + A+ T
Sbjct: 2732 SGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKS--LDHETTKWYQFSILARCT 2785
Score = 34.3 bits (75), Expect = 3.4
Identities = 17/38 (44%), Positives = 22/38 (57%)
Query: 76 QISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
Q+ + + V V +EDVNDN P F+ Y V V E P G
Sbjct: 906 QLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEG 943
Score = 34.3 bits (75), Expect = 3.4
Identities = 15/46 (32%), Positives = 24/46 (52%)
Query: 68 VRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
+R L A + V + ++D+NDN P+F Y VT+ E + G
Sbjct: 2257 IRATDSLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIG 2302
>AF231022-1|AAF61928.1| 4349|Homo sapiens protocadherin Fat 2 protein.
Length = 4349
Score = 147 bits (356), Expect = 3e-34
Identities = 158/690 (22%), Positives = 299/690 (43%), Gaps = 42/690 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D+D G + Y I+G FS+D G + K +D + L + +V+
Sbjct: 480 VTATDRDHGENGYVTYS-IAGPKALPFSIDPYLGIISTSKPMD----YELMKRIYTFRVR 534
Query: 278 ASQLNNPLKTA-QARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
AS +P + + + ++L +LNDN P FE SI ++ P G S++ + A D D+
Sbjct: 535 ASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDEL 594
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTV-LDREAHSSLRMKVYAKETNPSVVGTFA 395
+N ++ + F ++ SG ++++ + L +S +K+ A + T
Sbjct: 595 QNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPT-- 652
Query: 396 DSQRIAKWRRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDN 455
+ I + E +KT V T I +++ ++ N
Sbjct: 653 -TLNITVVKDPHFEVPVTCDKTG-VLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHY 710
Query: 456 NPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINP 515
P F + + + T + ++ A DPD G NG ++Y + + F I
Sbjct: 711 TPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNE---EGCFDIEL 767
Query: 516 NTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMG 575
TG ++VA E + + + + ++ S ++T+ V K + P F
Sbjct: 768 ETGLLTVAAPLDYEATNFYILNVTVYDLG-TPQKSSWKLLTVNV----KDWNDNAPRFPP 822
Query: 576 APYEFWVGSNVGIGTSVGQIRVNDAFEQND--VSYDLLHGYEEGVPFAVEERSGVITVVD 633
Y+ + + +GT++ ++ DA +++ V Y LL E+ F++ +G + V
Sbjct: 823 GGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK---FSLHPLTGELVVTG 879
Query: 634 DLSRYNRPMYDFEAVALQENA---NLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKE 690
L R + P Y + A + + L VT+ + + DVND + H+ + V E
Sbjct: 880 HLDRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCIT-EHNRL--KVPE 936
Query: 691 NSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRD 750
+ + + + G VR+++ + T + + G + ++ LD E+R
Sbjct: 937 DLPPGTVLTFLDASDPDL--GPAGEVRYVLMDGAHGTFRVDLM-TGALILERELDFERRA 993
Query: 751 VYRMTVIAEFNKGVISGAGIYQVTIYIEDENDN--PPVFEHATYEGFIMENSKIGTEIKM 808
Y +++ A ++ + V + + D N+N PP F ++G + ENS GT++
Sbjct: 994 GYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQV-- 1051
Query: 809 DNIIKATDADEGTNALFMYTL-FGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVA 867
++ A D D G + Y L G G F ++++TG+++ + LDRE Y L+++A
Sbjct: 1052 -IVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLA-PLDREFASYYWLTVLA 1109
Query: 868 RDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
D G LSS E+ I + D NDN P+ +Q
Sbjct: 1110 VDRGSVPLSSVTEVYIEVTDANDNPPQMSQ 1139
Score = 130 bits (313), Expect = 5e-29
Identities = 130/474 (27%), Positives = 211/474 (44%), Gaps = 30/474 (6%)
Query: 440 MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
++F V++ L D NDN P F S Y S++SN + + +V A D D GQN V Y +
Sbjct: 2566 VAFCTVKIILTDENDNPPQFKASE-YTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSV 2624
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPI-LEGRHA-LFVEASDQPANPSERRYSLAVVTI 557
+ +INP TG V V +S + LE + F++A D P SL V +
Sbjct: 2625 NPED--LVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQD--GGPPHWN-SLVPVRL 2679
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGY--- 614
+V K +P F Y F ++ G+ +G ++ A Q+ V Y L+ G
Sbjct: 2680 QVVP----KKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAA--QDPVIYSLVRGTTPE 2733
Query: 615 --EEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVA-LQENANLSIVTNATVHVVDVND 671
++GV F+++ +GVI V + + +Y + +A +N ++ + + + V DVND
Sbjct: 2734 SNKDGV-FSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVND 2792
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYG-NGTGNVRFLIANQQDVTDDI 730
R V + ++ + G ++ Q+ T + G +G + R +V +
Sbjct: 2793 NRPVFEADPYKAVL--TENMPVGTSVIQV--TAIDKDTGRDGQVSYRLSADPGSNVHELF 2848
Query: 731 AI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
AI +E G I T + LD E Y V+A + I + V + I DENDN P F
Sbjct: 2849 AIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFAS 2908
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFI 849
Y G ++ENS+ G + + A D E + Y G+ F + + +
Sbjct: 2909 EEYRGSVVENSEPGELVATLKTLDA-DISEQNRQVTCYITEGDPLGQFGISQVGDEWRIS 2967
Query: 850 G-DSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKV 902
+LDRE Y L + A D G + + I + D NDN P+ +Q+ KV
Sbjct: 2968 SRKTLDREHTAKYLLRVTASD-GKFQASVTVEIFVLDVNDNSPQCSQLLYTGKV 3020
Score = 125 bits (301), Expect = 1e-27
Identities = 128/460 (27%), Positives = 195/460 (42%), Gaps = 26/460 (5%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S V V + ++ + P F LY FS + G+ IG VKAV V+Y L
Sbjct: 2673 SLVPVRLQVVPKKVSLPKF-SEPLYTFSAPEDLPEGSEIGIVKAV----AAQDPVIYSLV 2727
Query: 501 R--TSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIE 558
R T F ++P+TG + V + P+ L+ D A+ + +++V++
Sbjct: 2728 RGTTPESNKDGVFSLDPDTGVIKVRK-PMDHESTKLY--QIDVMAHCLQNTDVVSLVSVN 2784
Query: 559 VTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEE 616
+ G + P F PY+ + N+ +GTSV Q+ D VSY L
Sbjct: 2785 IQVGDVNDNR--PVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGS 2842
Query: 617 GVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERG 674
V FA++ SG IT + +L Y F VA + + + A V V + DE
Sbjct: 2843 NVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQV-SITDEND 2901
Query: 675 VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA-IA 733
+ A V ENS + T + I ++ I+ +
Sbjct: 2902 NAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVG 2961
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
++ I ++K LDRE Y + V A K S V I++ D NDN P Y
Sbjct: 2962 DEWRISSRKTLDREHTAKYLLRVTASDGKFQAS----VTVEIFVLDVNDNSPQCSQLLYT 3017
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
G + E+ G I + ATD D TNA Y+L G G F +D +TG + + +L
Sbjct: 3018 GKVHEDVFPGHFILK---VSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELTTL-TAL 3073
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEF 893
DRE+K ++ L A D GG S +A++ + + D NDN P F
Sbjct: 3074 DRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRF 3113
Score = 119 bits (287), Expect = 7e-26
Identities = 149/580 (25%), Positives = 244/580 (42%), Gaps = 51/580 (8%)
Query: 589 GTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAV 648
G+ V +RV AF ++ Y +L E V F + R+G+IT + ++R Y
Sbjct: 378 GSRVVMVRVTPAFP--NLQY-VLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIR 434
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSS 707
A+ +V + +VD N+ + + ++ + EN G ++ + T+
Sbjct: 435 TSPGQASTVVV----IDIVDCNNHAPLFNRSSYDGTL---DENIPPGTSVLAVTATDRD- 486
Query: 708 IYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDRE-KRDVYRMTVIAEFNKGVIS 766
+G G V + IA + + I G I T KP+D E + +Y V A
Sbjct: 487 -HGEN-GYVTYSIAGPKALPFSID-PYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFR 543
Query: 767 GAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFM 826
+ + + + NDN P+FE G I ++ +G I + A D DE N +
Sbjct: 544 REKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMT---MSAIDVDELQNLKYE 600
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGD--SLDREKKIMYKLSLVARDTGGLSSEAEL-IIMI 883
+ G E FD++ +GV+ +L + Y L + A D +S L I ++
Sbjct: 601 I-VSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVV 659
Query: 884 GDENDNKP----EFNQIEENSKVRIH---RETKLNGTAGFTIIEVKPKNKFALDVDQLGP 936
D + P + + + +K +H + + + FT + N + + P
Sbjct: 660 KDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFP 719
Query: 937 LFL-IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVIN 995
+ + E++PI T + +L A D D+G NG++ Y + AD E + F I
Sbjct: 720 QSIDVLESVPINTPLARLAATDPDAGFNGKLVY------------VIADGNE-EGCFDIE 766
Query: 996 ERHGHVIVARSLPPESE--FRLNISALDGGNLNDNI--SVRVFVKDVNDHFPVFKKTWYN 1051
G + VA L E+ + LN++ D G + + V VKD ND+ P F Y
Sbjct: 767 LETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQ 826
Query: 1052 FNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRE 1111
+ E + ++ DAD N + Y + S T+ F + PLTG L V G LDRE
Sbjct: 827 LTISEDTEVGTTIAELTTKDADSEDNGRVRYTLL-SPTE-KFSLHPLTGELVVTGHLDRE 884
Query: 1112 TEDKYILTVVARDN-GXXXXXXXXXXXXXXXXDVNDNSPK 1150
+E +YIL V ARD DVNDNSP+
Sbjct: 885 SEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQ 924
Score = 111 bits (267), Expect = 2e-23
Identities = 130/487 (26%), Positives = 208/487 (42%), Gaps = 55/487 (11%)
Query: 431 NIEYYD---EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDP 487
N+ YD Q S+ + V + D NDN P F P Y+ ++ + +VGT I ++ D
Sbjct: 789 NVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG-YQLTISEDTEVGTTIAELTTKDA 847
Query: 488 DLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANP 545
D NG V Y L L+ T F ++P TG + V E R+ L VEA DQP+
Sbjct: 848 DSEDNGRVRYTL-----LSPTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSK- 901
Query: 546 SERRYSLA--VVTIEVTRG------TKGNKPDIPDFM--GAPYEFWVGSNVGIGTSVGQI 595
+ +S+ ++T+E T+ N+ +P+ + G F S+ +G + G++
Sbjct: 902 GHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPA-GEV 960
Query: 596 RVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN 655
R V D HG F V+ +G + + +L R Y+ A
Sbjct: 961 RY--------VLMDGAHG-----TFRVDLMTGALILERELDFERRAGYNLSLWASDGGRP 1007
Query: 656 LSIVTNATVHVV--DVNDERGVLLKGAHSPIIFH---VKENSAGAAIGQIFHTNMSSIYG 710
L+ T V V+ DVN+ L H H V+ENS Q+
Sbjct: 1008 LARRTLCHVEVIVLDVNEN----LHPPHFASFVHQGQVQENSPSGT--QVIVVAAQDDDS 1061
Query: 711 NGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGI 770
G +++ + + + G I T PLDRE Y +TV+A ++G + + +
Sbjct: 1062 GLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLA-VDRGSVPLSSV 1120
Query: 771 YQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL- 829
+V I + D NDNPP A + I E++ +GT + + A D D + + +
Sbjct: 1121 TEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQ---LDAWDPDSSSKGKLTFNIT 1177
Query: 830 FGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDEN 887
G F + TG++ LDRE K + L + D G L S + +++ I D N
Sbjct: 1178 SGNYMGFFMIHPVTGLLS-TAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVN 1236
Query: 888 DNKPEFN 894
DN P F+
Sbjct: 1237 DNPPIFS 1243
Score = 109 bits (262), Expect = 7e-23
Identities = 134/477 (28%), Positives = 204/477 (42%), Gaps = 43/477 (9%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + +AN +P F +LYE + NA VGT + + A+D D G G + Y +
Sbjct: 2465 VPVYINTTNANKYSPEF-QQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTI--- 2520
Query: 503 SNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
N + F INPN G ++ + E + + R +A T+++
Sbjct: 2521 INKLASEKFSINPN-GQIATLQKLDRENSTERVIAIKVMARDGGGR---VAFCTVKIILT 2576
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE-QN-DVSYDLLHGYEEGVPF 620
+ + P P F + Y + SNV + V Q+ DA E QN DV+Y + E+ V
Sbjct: 2577 DENDNP--PQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSV--NPEDLVKD 2632
Query: 621 AVEER--SGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHV-VDVNDERGVLL 677
+E +GV+ V D L DF + Q+ N+ V V + V ++ L
Sbjct: 2633 VIEINPVTGVVKVKDSLVGLENQTLDF-FIKAQDGGPPH--WNSLVPVRLQVVPKKVSLP 2689
Query: 678 KGAHSPIIFHVKEN-SAGAAIGQIFHTNMSS--IYGNGTGNVRFLIANQQDVTDDIAIAE 734
K + F E+ G+ IG + IY G +N+ V +
Sbjct: 2690 KFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTP--ESNKDGVFS--LDPD 2745
Query: 735 DGTIFTQKPLDREKRDVYRMTVIAEF--NKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
G I +KP+D E +Y++ V+A N V+S + V I + D NDN PVFE Y
Sbjct: 2746 TGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVS---LVSVNIQVGDVNDNRPVFEADPY 2802
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG----KEMFDVDENTGVVKF 848
+ + EN +GT + + A D D G + Y L + E+F +D +G +
Sbjct: 2803 KAVLTENMPVGTSVIQ---VTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITT 2859
Query: 849 IGDSLDREKKIMYKLSLVARDTG---GLSSEAELIIMIGDENDNKPEFNQIEENSKV 902
+ LD E Y +VA D G LSS+A + + I DENDN P F E V
Sbjct: 2860 L-QELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSV 2915
Score = 105 bits (251), Expect = 2e-21
Identities = 118/463 (25%), Positives = 206/463 (44%), Gaps = 42/463 (9%)
Query: 449 LLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTIT 508
+ + N + P F+ + YE + + G + +V+A+D D G++ ++Y + + +
Sbjct: 1438 IANINHHRPQFLETR-YEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHGSQDPGSA 1494
Query: 509 SPFKINPNTGT-VSVAESPILEG--RHALFVEASDQPANPSERRYSLAVVTIEVTRGTKG 565
S F+++P++G V+V + + G +H L V DQ P +R + VTI V G
Sbjct: 1495 SLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEI-PIKRNF--VWVTIHVEDGNL- 1550
Query: 566 NKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGYEEGVPFAVE 623
P P F YE V + GT + Q+R DA +V Y LL G EG F +
Sbjct: 1551 -HP--PRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGF-FNIN 1606
Query: 624 ERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLLKGAHS 682
G+IT+ L + N + A + + + +HV + + K S
Sbjct: 1607 ALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSK---S 1663
Query: 683 PIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQ 741
+ E+ G+ I + + S + T +R N+ V + + G I TQ
Sbjct: 1664 EYFVEIPESIPVGSPILLVSAMSPSEV----TYELRE--GNKDGVFSMNSYS--GLISTQ 1715
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
K LD EK Y++ + G + V + I DENDN P+F +T+ G I E +
Sbjct: 1716 KKLDHEKISSYQLKIRGSNMAGAFTDV---MVVVDIIDENDNAPMFLKSTFVGQISEAAP 1772
Query: 802 IGTEIKMDN----IIKATDADEGTNALFMYTLF-GEGKEMFDVDENTGVVKFIGDSLDRE 856
+ + I N +I A+D+D+ N+L +Y + E + F +D + G + + + +D E
Sbjct: 1773 LYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSE-MDYE 1831
Query: 857 KKIMYKLSLVARDTGG----LSSEAELIIMIGDENDNKPEFNQ 895
++ + D G A++II + D ND+ P F++
Sbjct: 1832 SMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSE 1874
Score = 102 bits (244), Expect = 1e-20
Identities = 116/454 (25%), Positives = 191/454 (42%), Gaps = 30/454 (6%)
Query: 451 DANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSP 510
D NDN P F PS+ ++ N V T + V A DPD G N V+Y L ++
Sbjct: 3105 DVNDNAPRFFPSHC-AVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAE----GH 3159
Query: 511 FKINPNTGTVSVAESPILEGRHA---LFVEASDQPANPSERRYSLAVVTIEVTRGTKGNK 567
F I+ TG + + E P+ A L V ASD P +L VT+ V G +
Sbjct: 3160 FSIDATTGVIRL-EKPLQVRPQAPLELTVRASDL-GTPIPLS-TLGTVTVSVV----GLE 3212
Query: 568 PDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSG 627
+P F+ + V + GT V Q+ Y ++ G E+G F ++ R+G
Sbjct: 3213 DYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVSGNEQG-RFRLDARTG 3271
Query: 628 VITVVDDLSRYNRPMYDFEA-VALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIF 686
++ V L P Y + + +++LS VT V++ DVN+ R + +S
Sbjct: 3272 ILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYST--- 3328
Query: 687 HVKENSAGAAIGQIFHT-NMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLD 745
V EN A +G + T + + G ++ + + + + G + K LD
Sbjct: 3329 RVLEN---ALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALD 3385
Query: 746 REKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTE 805
RE+ Y + + A + G + I + D NDNPP F Y + ENS IG++
Sbjct: 3386 REQASSYSLKLRAT-DSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSK 3444
Query: 806 IKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSL 865
+ + I+ D+ E G F V + +V + L R + Y+L +
Sbjct: 3445 V-LQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLV--TAEGLSRRAQEWYQLQI 3501
Query: 866 VARDTG--GLSSEAELIIMIGDENDNKPEFNQIE 897
A D+G LSS + + + +++ P +E
Sbjct: 3502 QASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLE 3535
Score = 99 bits (238), Expect = 6e-20
Identities = 142/588 (24%), Positives = 241/588 (40%), Gaps = 49/588 (8%)
Query: 324 SVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
+++QV TD++ +N + ++ +G+ + G L +T+ + + ++ Y
Sbjct: 2890 ALVQVSITDEN--DNAP-RFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYI 2946
Query: 384 KETNPSVVGTFADSQRIAKWRRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLMSFV 443
E +P +G F SQ +WR +T Y+ + D + + V
Sbjct: 2947 TEGDP--LGQFGISQVGDEWRISSRKTLDREHTAKYLL---------RVTASDGKFQASV 2995
Query: 444 NVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTS 503
VE+ +LD NDN+P LY + + G I KV A D D N + Y L
Sbjct: 2996 TVEIFVLDVNDNSPQ-CSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPG 3054
Query: 504 NLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRGT 563
FK++P+TG ++ + E + + A A R A +T+ V
Sbjct: 3055 ----AHEFKLDPHTGELTTLTALDRERKDVFNLVAK---ATDGGGRSCQADITLHV---- 3103
Query: 564 KGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGYEEGVPFA 621
+ + P F + V N + T V + D + V Y L E F+
Sbjct: 3104 EDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGH--FS 3161
Query: 622 VEERSGVITVVDDLS-RYNRPM-YDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKG 679
++ +GVI + L R P+ A L LS + TV VV + D V L
Sbjct: 3162 IDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNT 3221
Query: 680 AHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIF 739
HS + ++ G + Q+ ++ TG R + N+Q A G ++
Sbjct: 3222 EHSVQV--PEDAPPGTEVLQL--ATLTRPGAEKTG-YRVVSGNEQGRFR--LDARTGILY 3274
Query: 740 TQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMEN 799
LD E Y +++ K S + + V + I D N++ P F Y ++EN
Sbjct: 3275 VNASLDFETSPKYFLSIECS-RKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLEN 3333
Query: 800 SKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM--FDVDENTGVVKFIGDSLDREK 857
+ +G I + ATD D N+ Y+L G G ++ F + G ++ + +LDRE+
Sbjct: 3334 ALVGDVILT---VSATDEDGPLNSDITYSLIG-GNQLGHFTIHPKKGELQ-VAKALDREQ 3388
Query: 858 KIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVR 903
Y L L A D+G L + ++ I + D NDN P F Q+ ++ V+
Sbjct: 3389 ASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQ 3436
Score = 91.9 bits (218), Expect = 2e-17
Identities = 104/473 (21%), Positives = 203/473 (42%), Gaps = 34/473 (7%)
Query: 444 NVEVTLLDANDN-NPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
+VEV +LD N+N +P S +++ ++ N+ GT + V A D D G +G + Y L+
Sbjct: 1015 HVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAG 1074
Query: 503 SNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLAVVTIEV 559
+ L + F IN +TG + +P+ + L V A D+ + P S+ V IEV
Sbjct: 1075 TGL---AAFSINQDTGMIQTL-APLDREFASYYWLTVLAVDRGSVPLS---SVTEVYIEV 1127
Query: 560 TRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEG 617
T N P + + P + + +GTSV Q+ D+ + +++++ G G
Sbjct: 1128 T-DANDNPPQMSQAVFYPS---IQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMG 1183
Query: 618 VPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVL 676
F + +G+++ L R N+ + E L +L + V ++DVND +
Sbjct: 1184 F-FMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIF 1242
Query: 677 LKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDG 736
+H + E + + G ++ S + G V + I + + I + G
Sbjct: 1243 ---SHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSYEEAFSIDLVT-G 1298
Query: 737 TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFI 796
+ + + ++ + + + ++ I + P F+ Y +
Sbjct: 1299 VVSSNSTFTAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTV 1358
Query: 797 MENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM-FDVDENTGVVKFIGDSLDR 855
ME + + + ++ EG LF + + G K+M FD+++ TG + I LD
Sbjct: 1359 METDPVNHMVGVISV-------EGRPGLFWFNISGGDKDMDFDIEKTTGSI-VIARPLDT 1410
Query: 856 EKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRET 908
++ Y L++ D + I MI + N ++P+F +E +VR+ ++T
Sbjct: 1411 RRRSNYNLTVEVTDGSRTIATQVHIFMIANINHHRPQF--LETRYEVRVPQDT 1461
Score = 91.9 bits (218), Expect = 2e-17
Identities = 112/478 (23%), Positives = 192/478 (40%), Gaps = 41/478 (8%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
++S V+V + + D NDN PVF ++ Y+ + N VGT + +V A+D D G++G V Y
Sbjct: 2777 VVSLVSVNIQVGDVNDNRPVF-EADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYR 2835
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIE 558
L + F I+ +G ++ + E + + S A+V +
Sbjct: 2836 LSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVS 2895
Query: 559 VTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGV 618
+T + P F Y V N G V ++ DA + ++ + + EG
Sbjct: 2896 IT----DENDNAPRFASEEYRGSVVENSEPGELVATLKTLDA-DISEQNRQVTCYITEGD 2950
Query: 619 PFAVEERSGVITVVDDLSRYNRPMYDFEAVA------LQENANLSIVTNATVHVVDVNDE 672
P + G+ V D+ +R D E A + + V+DVND
Sbjct: 2951 PLG---QFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQASVTVEIFVLDVNDN 3007
Query: 673 ----RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYG-NGTGNVRFLIANQQDVT 727
+L G +F +A TN Y +G G F +
Sbjct: 3008 SPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLD------ 3061
Query: 728 DDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVF 787
G + T LDRE++DV+ + A G A +T+++ED NDN P F
Sbjct: 3062 -----PHTGELTTLTALDRERKDVFNLVAKATDGGGRSCQA---DITLHVEDVNDNAPRF 3113
Query: 788 EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVK 847
+ + +N+ + T + ++ A D D+G NA +Y+L + F +D TGV++
Sbjct: 3114 FPSHCAVAVFDNTTVKTPVA---VVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIR 3170
Query: 848 FIGDSLDREKKIMYKLSLVARDTG---GLSSEAELIIMIGDENDNKPEFNQIEENSKV 902
+ L + +L++ A D G LS+ + + + D P F E + +V
Sbjct: 3171 -LEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQV 3227
Score = 88.6 bits (210), Expect = 1e-16
Identities = 154/676 (22%), Positives = 256/676 (37%), Gaps = 63/676 (9%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
A G I T K +D R Y++ + G V I I D N++ P+F ++Y
Sbjct: 410 ARTGLITTTKLMDFHDRAHYQLHIRTS------PGQASTVVVIDIVDCNNHAPLFNRSSY 463
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDS 852
+G + EN GT + + ATD D G N Y++ G F +D G++
Sbjct: 464 DGTLDENIPPGTSVLA---VTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIIS-TSKP 519
Query: 853 LDRE-KKIMYKLSLVARDTGG---LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRET 908
+D E K +Y + A D G E + + + + NDN+P F ++ +R
Sbjct: 520 MDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPV 579
Query: 909 KLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRY 968
+ I+V ++ L N G +K ++L +G Y
Sbjct: 580 G-KSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQ--PTSY 636
Query: 969 EFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS----LPPESEFRLNISALDGGN 1024
+ S L + V+ + H V V L ++ L+ L
Sbjct: 637 SLKITASDGKNYASPTTLNIT---VVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQE 693
Query: 1025 LNDNISVRVFVKDVNDHFPVFKKTW-YNFNVEEAQYTRRVLGKVDATDADFGQNANLTYF 1083
+D + +N + P F+ + + +V E+ L ++ ATD D G N L Y
Sbjct: 694 SSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYV 753
Query: 1084 IQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXD 1143
I + + F+I TG+L+V LD E + YIL V D G D
Sbjct: 754 IADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLG-TPQKSSWKLLTVNVKD 812
Query: 1144 VNDNSPKF----YAF---------DELLEWKHPEADELSNHNFESVMMIPVYKATIEENA 1190
NDN+P+F Y + E +AD N ++ P K ++
Sbjct: 813 WNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLH--- 869
Query: 1191 PIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVE 1250
P+ T V D ++ + ++Q + G L S L++T+ DV D
Sbjct: 870 PL--TGELVVTGHLDRESEPRYILKV---EARDQPSKG-HQLFSVTDLIITLEDVND--- 920
Query: 1251 MSDKPVFISRYYELEIEENVNAPVELVSLNLTEH--YENFKMRYYILNENDTDIRRTFVI 1308
+ P I+ + L++ E++ L L+ ++ ++RY +++ TF +
Sbjct: 921 --NSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMD----GAHGTFRV 974
Query: 1309 DPRNGTLYLVRSPDREVKDTYEVIVRAE---RQKYSRELPHMIYPVAEDVLEGMTKYDVK 1365
D G L L R D E + Y + + A R R L H + + DV E +
Sbjct: 975 DLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCH-VEVIVLDVNENLHPPHFA 1033
Query: 1366 VVVRIKDVNDNSPKFT 1381
V V +NSP T
Sbjct: 1034 SFVHQGQVQENSPSGT 1049
Score = 84.6 bits (200), Expect = 2e-15
Identities = 87/338 (25%), Positives = 145/338 (42%), Gaps = 23/338 (6%)
Query: 1011 SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDAT 1070
+++ L ++A DG +++V +FV DVND+ P + Y V E + + KV AT
Sbjct: 2978 AKYLLRVTASDG-KFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSAT 3036
Query: 1071 DADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXX 1130
D D NA +TY + F++ P TG L+ LDRE +D + L A D G
Sbjct: 3037 DLDTDTNAQITYSLHGPGAH-EFKLDPHTGELTTLTALDRERKDVFNLVAKATDGG---G 3092
Query: 1131 XXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENA 1190
DVNDN+P+F+ H N ++ + + V+ ++ A
Sbjct: 3093 RSCQADITLHVEDVNDNAPRFFP-------SHCAVAVFDNTTVKTPVAV-VFARDPDQGA 3144
Query: 1191 PIGTTVAKVFANDTDF-IGNGNGLILYSLP-QRKNQQNLGLPSLSS---TAILMVTVADV 1245
+ + + F I G+I P Q + Q L L +S T I + T+ V
Sbjct: 3145 NAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTV 3204
Query: 1246 P-DEVEMSD-KPVFISRYYELEIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIR 1303
V + D PVF++ + +++ E+ E++ L K Y +++ N+ +
Sbjct: 3205 TVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVSGNE---Q 3261
Query: 1304 RTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYS 1341
F +D R G LY+ S D E Y + + R+ S
Sbjct: 3262 GRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSS 3299
Score = 82.6 bits (195), Expect = 1e-14
Identities = 55/173 (31%), Positives = 85/173 (49%), Gaps = 12/173 (6%)
Query: 223 QDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLN 282
QD + + +R N +FSLD G + + K +D ++ + + V A L
Sbjct: 2719 QDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHES-----TKLYQIDVMAHCLQ 2773
Query: 283 NPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFT 342
N + V I++ D+NDN P FE D Y + EN+P G SV+QV A DKD G +G+ +
Sbjct: 2774 NTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVS 2833
Query: 343 YQLDDPKGA-----FSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSV 390
Y+L G+ F+ID SGW+T + LD E + V A + ++
Sbjct: 2834 YRLSADPGSNVHELFAIDSESGWITTLQE--LDCETCQTYHFHVVAYDHGQTI 2884
Score = 81.4 bits (192), Expect = 2e-14
Identities = 123/506 (24%), Positives = 209/506 (41%), Gaps = 49/506 (9%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V++ D NDN P F Y ++ + G V+ +V A D DLG NG V Y+
Sbjct: 2056 VRVSIEDVNDNPPKFKHLPYYTI-IQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYT 2114
Query: 505 LTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F+I+P G +S+ + + ++ L V A D PS + +VT+
Sbjct: 2115 Y-----FRIDPYLGDISLKKPFDYQALNKYHLKVIARD-GGTPSLQSEEEVLVTVR---- 2164
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAV 622
K N P F Y+ V N+ + T + + E + Y+++ E + F
Sbjct: 2165 NKSN----PLFQSPYYKVRVPENITLYTPILHTQARSP-EGLRLIYNIVE-EEPLMLFTT 2218
Query: 623 EERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV--DVNDERGVLLKGA 680
+ ++GV+TV L ++ + F A + L + ATV V+ DVND +
Sbjct: 2219 DFKTGVLTVTGPLDYESKTKHVFTVRA--TDTALGSFSEATVEVLVEDVNDNPPTFSQLV 2276
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDGTIF 739
++ I + A + Q+ ++ S G ++ + DV+ I G +
Sbjct: 2277 YTTSI--SEGLPAQTPVIQLLASDQDS--GRNRDVSYQIVEDGSDVSKFFQINGSTGEMS 2332
Query: 740 TQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMEN 799
T + LD E + + + V A +KG G V + + D NDNPP F YE + E
Sbjct: 2333 TVQELDYEAQQHFHVKVRA-MDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSEL 2391
Query: 800 SKIGTEIKMDNIIKATDAD-EGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKK 858
+ G + ++A D D T+ L L G F ++ ++G++ + +
Sbjct: 2392 ATCGHLVLK---VQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMF-NLCKKHLD 2447
Query: 859 IMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQ------IEENSKV--------RI 904
Y L + A D G + + I + N PEF Q + EN+ V I
Sbjct: 2448 SSYNLRVGASD-GVFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAI 2506
Query: 905 HRETKLNGTAGFTIIEVKPKNKFALD 930
+++ GT +TII KF+++
Sbjct: 2507 DKDSGPYGTIDYTIINKLASEKFSIN 2532
Score = 81.4 bits (192), Expect = 2e-14
Identities = 95/398 (23%), Positives = 160/398 (40%), Gaps = 26/398 (6%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP--IGPSLTIPLTVPRGLTI 140
V V IEDVNDN P F PY+ + + T G+ F +G + + T
Sbjct: 2056 VRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYTY 2115
Query: 141 FKD---IRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAGDKE 196
F+ + KP + Y + V D G +L+S + ++ +R + +
Sbjct: 2116 FRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVR-----NKSNPL 2170
Query: 197 FQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLE 256
FQ R+ + I PI G L Y ++ LF+ D G L +
Sbjct: 2171 FQSPYYKV--RVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVT 2228
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
LD +++ + F ++ + L + ++A VE+ + D+NDN P F Y SI
Sbjct: 2229 GPLDYESKTK---HVFTVRATDTALGS---FSEATVEVLVEDVNDNPPTFSQLVYTTSIS 2282
Query: 317 ENLPNGFSVLQVMATDKDQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDRE 372
E LP V+Q++A+D+D G N + +YQ+ D F I+ +G ++ + LD E
Sbjct: 2283 EGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQE--LDYE 2340
Query: 373 AHSSLRMKVYAKET-NPSVVGTFADSQRIAKWRRQPLETNAPLEKTTYVFPDKVGTKTEN 431
A +KV A + +P + G ++ P E P + G
Sbjct: 2341 AQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLK 2400
Query: 432 IEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSM 469
++ D +E +L N + F+ S+ SM
Sbjct: 2401 VQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISM 2438
Score = 80.2 bits (189), Expect = 5e-14
Identities = 67/216 (31%), Positives = 102/216 (47%), Gaps = 18/216 (8%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN P GT +I + A D DSGL+G+++Y + + L+A F IN+ G
Sbjct: 1041 VQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAG-----TGLAA--------FSINQDTG 1087
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+ L E S + L + A+D G+ L+ V + V D ND+ P + + +++
Sbjct: 1088 MIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQ 1147
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E + ++DA D D LT+ I + F I P+TG+LS +LDRE +D+
Sbjct: 1148 EDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDE 1207
Query: 1116 YILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
+IL V DNG DVNDN P F
Sbjct: 1208 HILEVTVLDNG-EPSLKSTSRVVVGILDVNDNPPIF 1242
Score = 78.6 bits (185), Expect = 2e-13
Identities = 66/221 (29%), Positives = 100/221 (45%), Gaps = 24/221 (10%)
Query: 939 LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSAD-ALEVKRYFVINER 997
++ EN+P+GT++I++ A+D D+G +GQ+ Y +LSAD V F I+
Sbjct: 2805 VLTENMPVGTSVIQVTAIDKDTGRDGQVSY-----------RLSADPGSNVHELFAIDSE 2853
Query: 998 HGHVIVARSLPPES--EFRLNISALDGG---NLNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
G + + L E+ + ++ A D G L+ V+V + D ND+ P F Y
Sbjct: 2854 SGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRG 2913
Query: 1053 NVEEAQYTRRVLGKVDATDADFG-QNANLTYFIQPSDTDLPFEISPLTGV--LSVNGELD 1109
+V E ++ + DAD QN +T +I D F IS + +S LD
Sbjct: 2914 SVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLD 2973
Query: 1110 RETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
RE KY+L V A D DVNDNSP+
Sbjct: 2974 REHTAKYLLRVTASDG----KFQASVTVEIFVLDVNDNSPQ 3010
Score = 78.2 bits (184), Expect = 2e-13
Identities = 122/502 (24%), Positives = 206/502 (41%), Gaps = 66/502 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I E +P T +I+L A D DSG N + Y+ + D +V ++F IN G
Sbjct: 2281 ISEGLPAQTPVIQLLASDQDSGRNRDVSYQ-----------IVEDGSDVSKFFQINGSTG 2329
Query: 1000 HVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+ + L E++ F + + A+D G+ L V V V D+ND+ P F++ Y NV
Sbjct: 2330 EMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVS 2389
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E ++ KV A D D + L Y I + D F I+ +G++S+ + +
Sbjct: 2390 ELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSS 2449
Query: 1116 YILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFES 1175
Y L V A D + N SP+F +H EL+ +
Sbjct: 2450 YNLRVGASDG----VFRATVPVYINTTNANKYSPEFQ--------QHLYEAELAENAMVG 2497
Query: 1176 VMMIPVYKATIEENAPIGT---TVAKVFANDTDFIG-NGNGLILYSLPQRKNQQN-LGLP 1230
+I + A +++ P GT T+ A++ I NG L L + + + + +
Sbjct: 2498 TKVIDLL-AIDKDSGPYGTIDYTIINKLASEKFSINPNGQIATLQKLDRENSTERVIAIK 2556
Query: 1231 SLSSTA---ILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEHY 1285
++ + TV + + E + P F + Y + I+ NV ++PV V +
Sbjct: 2557 VMARDGGGRVAFCTVKIILTD-ENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEG 2615
Query: 1286 ENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
+N + Y + N D ++ I+P G + +VKD+ +V E Q
Sbjct: 2616 QNADVTYSV-NPEDL-VKDVIEINPVTGVV--------KVKDS---LVGLENQTLD---- 2658
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDV--NDNSPKFTNGNRPLVT-AIPTTAPFGYQVM 1402
+ A+D G ++ V VR++ V + PKF + PL T + P P G ++
Sbjct: 2659 --FFIKAQD--GGPPHWNSLVPVRLQVVPKKVSLPKF---SEPLYTFSAPEDLPEGSEIG 2711
Query: 1403 QLKGAIGHHPTASRTVRADTDE 1424
+K P VR T E
Sbjct: 2712 IVKAVAAQDPVIYSLVRGTTPE 2733
Score = 77.8 bits (183), Expect = 3e-13
Identities = 48/156 (30%), Positives = 82/156 (52%), Gaps = 9/156 (5%)
Query: 233 YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV 292
Y ++SGN++ F LD+ G L++ LD + + L ++ S+ ++ + V
Sbjct: 3253 YRVVSGNEQGRFRLDARTGILYVNASLDFETSPK-----YFLSIECSRKSSSSLSDVTTV 3307
Query: 293 EIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKG 350
+ + D+N++ P+F D Y+ ++EN G +L V ATD+D N + TY L + G
Sbjct: 3308 MVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLG 3367
Query: 351 AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKET 386
F+I P+ G L V LDRE SS +K+ A ++
Sbjct: 3368 HFTIHPKKGELQVAK--ALDREQASSYSLKLRATDS 3401
Score = 77.0 bits (181), Expect = 5e-13
Identities = 84/323 (26%), Positives = 141/323 (43%), Gaps = 27/323 (8%)
Query: 77 ISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPR 136
+S +VTV + + D +P+FL+T + V V E P G + + +A +LT P
Sbjct: 3198 LSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTE--VLQLA----TLTRPGAEKT 3251
Query: 137 GLTIFK-DIRAFDRDKPNTPNSDVHYSIVSGNDDGHF-ALESSHKPVLLLRKVLDY---- 190
G + + + R T V+ S+ +F ++E S K L V
Sbjct: 3252 GYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNI 3311
Query: 191 -DAGDKEFQLVIMASGKRIHKEILFPEPI---HAIDQDLGVGATLRYELISGNDRKLFSL 246
D + Q R+ + L + I A D+D + + + Y LI GN F++
Sbjct: 3312 TDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTI 3371
Query: 247 DSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF 306
G L + K LD + QA+++ L+++A+ P + I++ D+NDN P F
Sbjct: 3372 HPKKGELQVAKALDRE-----QASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRF 3426
Query: 307 EVDFYNISIVENLPNGFSVLQVMATDKDQGENG---EFTYQLDDPKGAFSIDPRSGWLTV 363
Y+ ++ EN P G VLQ++ +D D ENG F + AF + P GWL
Sbjct: 3427 FQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTP-DGWLVT 3485
Query: 364 RNQTVLDREAHSSLRMKVYAKET 386
L R A ++++ A ++
Sbjct: 3486 AEG--LSRRAQEWYQLQIQASDS 3506
Score = 74.5 bits (175), Expect = 3e-12
Identities = 107/473 (22%), Positives = 194/473 (41%), Gaps = 35/473 (7%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
QL S V+V++ D NDN P F S Y S+ N++ G ++ +K +D D+ +
Sbjct: 2885 QLSSQALVQVSITDENDNAPRFA-SEEYRGSVVENSEPGELVATLKTLDADISEQ----- 2938
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQ---PANPSERRYSLAV 554
+ Q T +T P G V + + R L E + + S+ ++ A
Sbjct: 2939 NRQVTCYITEGDPL---GQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQ-AS 2994
Query: 555 VTIEV-TRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND--VSYDLL 611
VT+E+ N P + Y V +V G + ++ D + ++Y L
Sbjct: 2995 VTVEIFVLDVNDNSPQCSQLL---YTGKVHEDVFPGHFILKVSATDLDTDTNAQITYS-L 3050
Query: 612 HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVND 671
HG F ++ +G +T + L R + +++ A A + S + T+HV DVND
Sbjct: 3051 HG-PGAHEFKLDPHTGELTTLTALDRERKDVFNLVAKA-TDGGGRSCQADITLHVEDVND 3108
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
+ +F + + +F + V + + + + I
Sbjct: 3109 NAPRFFPSHCAVAVF--DNTTVKTPVAVVFARDPDQ---GANAQVVYSLPDSAEGHFSID 3163
Query: 732 IAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
A G I +KPL + +TV A I + + VT+ + D PVF +
Sbjct: 3164 -ATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTE 3222
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD 851
+ + E++ GTE+ + AT G + G + F +D TG++ ++
Sbjct: 3223 HSVQVPEDAPPGTEV----LQLATLTRPGAEKTGYRVVSGNEQGRFRLDARTGIL-YVNA 3277
Query: 852 SLDREKKIMYKLSLVA--RDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKV 902
SLD E Y LS+ + + LS +++ I D N+++P+F Q +++V
Sbjct: 3278 SLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRV 3330
Score = 74.1 bits (174), Expect = 3e-12
Identities = 109/465 (23%), Positives = 194/465 (41%), Gaps = 41/465 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
+FV V + + D N + P F + YE S+ GT + +V+A+D D G N V Y L
Sbjct: 1537 NFVWVTIHVEDGNLHPPRFTQLH-YEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLL 1595
Query: 501 RTSNLTITSPFKINPNTGTVSVAE--SPILEGRHALFVEASDQPANPSERRYSLAVVTIE 558
+ ++ F IN G +++A+ H L V+A DQ S + + LA V I
Sbjct: 1596 KGNS---EGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQ---GSPQWHDLATVIIH 1649
Query: 559 VTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGV 618
V + P F + Y + ++ +G+ I + A ++V+Y+L G ++GV
Sbjct: 1650 VYPSDR----SAPIFSKSEYFVEIPESIPVGS---PILLVSAMSPSEVTYELREGNKDGV 1702
Query: 619 PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLK 678
F++ SG+I+ L Y + + A V ++D ND + LK
Sbjct: 1703 -FSMNSYSGLISTQKKLDHEKISSYQLK-IRGSNMAGAFTDVMVVVDIIDENDNAPMFLK 1760
Query: 679 GAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGN-----VRFLIANQQDVTDDIAIA 733
S + + E + ++ + N I+ + + + + I + +
Sbjct: 1761 ---STFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDP 1817
Query: 734 EDGTIFTQKPLDREKRDVYRMTV-IAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
GT+ +D E ++ V + + V+ QV I++ D ND+PP F Y
Sbjct: 1818 SMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIY 1877
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL-FGEGKEMFDVDENTGVVKFIGD 851
E I+ G E+ M ++A+D D N Y++ G E + TG + +
Sbjct: 1878 EVAIVGPIHPGMELLM---VRASDEDSEVN----YSIKTGNADEAVTIHPVTGSISVLNP 1930
Query: 852 SLDREKKIMYKLSLVARDTGGLSSEAELI-IMIGDENDNKPEFNQ 895
+ + KL++ A D GL + L+ I + D +F+Q
Sbjct: 1931 AF---LGLSRKLTIRASD--GLYQDTALVKISLTQVLDKSLQFDQ 1970
Score = 73.7 bits (173), Expect = 5e-12
Identities = 100/397 (25%), Positives = 165/397 (41%), Gaps = 43/397 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I E+ P+GT++++L+A D DS G++ + S Y+ +F+I+ G
Sbjct: 1146 IQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMG-------------FFMIHPVTG 1192
Query: 1000 HVIVARSLPPES--EFRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+ A+ L E+ E L ++ LD G +L V V + DVND+ P+F +N +
Sbjct: 1193 LLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLP 1252
Query: 1056 E--AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETE 1113
E + + + ++ A+D D G N +TY I+ S + F I +TGV+S N T
Sbjct: 1253 ERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSYEE-AFSIDLVTGVVSSNSTF---TA 1308
Query: 1114 DKY-ILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDE-LLEWKHPEADELSNH 1171
+Y ILT+ A D+G +S AFDE + E D + NH
Sbjct: 1309 GEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPL-AFDETYYSFTVMETDPV-NH 1366
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDF---IGNGNGLILYSLP---QRKNQQ 1225
M+ V E P G + D D I G I+ + P +R++
Sbjct: 1367 ------MVGVISV---EGRP-GLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNY 1416
Query: 1226 NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHY 1285
NL + + + V +P F+ YE+ + ++ VEL+ + +
Sbjct: 1417 NLTVEVTDGSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQD 1476
Query: 1286 ENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPD 1322
+ + Y I D F +DP +G L V D
Sbjct: 1477 KGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLD 1513
Score = 73.7 bits (173), Expect = 5e-12
Identities = 111/468 (23%), Positives = 199/468 (42%), Gaps = 52/468 (11%)
Query: 446 EVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGM-VLYDLQRTSN 504
EV + N +NP+F S Y+ + N + T I +A P+ G+ ++Y++
Sbjct: 2158 EVLVTVRNKSNPLF-QSPYYKVRVPENITLYTPILHTQARSPE----GLRLIYNIVEEEP 2212
Query: 505 LTI-TSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTR 561
L + T+ FK TG ++V E + H V A+D S + T+EV
Sbjct: 2213 LMLFTTDFK----TGVLTVTGPLDYESKTKHVFTVRATDTALG------SFSEATVEVLV 2262
Query: 562 GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH-GYEEGV 618
+ P P F Y + + T V Q+ +D + DVSY ++ G +
Sbjct: 2263 EDVNDNP--PTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSK 2320
Query: 619 PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVDVNDERGVLL 677
F + +G ++ V +L + + + A+ + + L+ T V+V D+ND
Sbjct: 2321 FFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFR 2380
Query: 678 KGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLI-ANQQDVTDDIAIAEDG 736
+ + + + + G + ++ + S T + +LI + QD I
Sbjct: 2381 QPQYEANVSELA--TCGHLVLKVQAIDPDS---RDTSRLEYLILSGNQD--RHFFINSSS 2433
Query: 737 TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTI--YIEDENDNP--PVFEHATY 792
I + L ++ D + +N V + G+++ T+ YI N N P F+ Y
Sbjct: 2434 GIISMFNLCKKHLD-------SSYNLRVGASDGVFRATVPVYINTTNANKYSPEFQQHLY 2486
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGE-GKEMFDVDENTGVVKFIGD 851
E + EN+ +GT++ +D + A D D G YT+ + E F ++ N +
Sbjct: 2487 EAELAENAMVGTKV-ID--LLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQIATL--Q 2541
Query: 852 SLDREKKI--MYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIE 897
LDRE + + ++ARD GG + + I++ DENDN P+F E
Sbjct: 2542 KLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASE 2589
Score = 72.5 bits (170), Expect = 1e-11
Identities = 166/726 (22%), Positives = 288/726 (39%), Gaps = 97/726 (13%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L S V + + DANDN P + Y S++ +A VGT + ++ A DPD G + ++
Sbjct: 1117 LSSVTEVYIEVTDANDNPPQMSQAVFYP-SIQEDAPVGTSVLQLDAWDPDSSSKGKLTFN 1175
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVT 556
+ + + F I+P TG +S A+ E + H L V D PS + S VV
Sbjct: 1176 ITSGNYMGF---FMIHPVTGLLSTAQQLDRENKDEHILEVTVLDN-GEPSLKSTSRVVVG 1231
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGY 614
I N P + S V G V ++ +D E V+Y + Y
Sbjct: 1232 I---LDVNDNPPIFSHKLFNVRLPERLSPVSPGP-VYRLVASDLDEGLNGRVTYSIEDSY 1287
Query: 615 EEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDER- 673
EE F+++ +GV++ S + Y+ + ++ + + +H+ + R
Sbjct: 1288 EEA--FSIDLVTGVVS---SNSTFTAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRP 1342
Query: 674 -GVLLKGAHSPIIFHVKENS-AGAAIGQIFHTNMSSIYGNGTGNVRFLIAN-QQDVTDDI 730
+ L + F V E +G I S+ G G F I+ +D+ DI
Sbjct: 1343 SSIPLAFDETYYSFTVMETDPVNHMVGVI------SVEGR-PGLFWFNISGGDKDMDFDI 1395
Query: 731 AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIY-IEDENDNPPVFEH 789
G+I +PLD +R Y +TV E G S QV I+ I + N + P F
Sbjct: 1396 E-KTTGSIVIARPLDTRRRSNYNLTV--EVTDG--SRTIATQVHIFMIANINHHRPQFLE 1450
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFI 849
YE + +++ G E+ ++A D D+G + + YT+ G ++ G
Sbjct: 1451 TRYEVRVPQDTVPGVELLR---VQAIDQDKGKSLI--YTIHGS--------QDPGSASLF 1497
Query: 850 GDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETK 909
LD ++ + + D G S+ L +M+ D+ E
Sbjct: 1498 --QLDPSSGVLVTVGKL--DLGSGPSQHTLTVMVRDQ--------------------EIP 1533
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
+ + I V+ N QL +P+ I GT ++++ A+D D G+N ++ Y
Sbjct: 1534 IKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHY- 1592
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPP--ESEFRLNISALDGGN--L 1025
S L ++ + +F IN G + +A+ L + L + A D G+
Sbjct: 1593 ---------SLLKGNS---EGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQW 1640
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
+D +V + V + P+F K+ Y + E+ + V A + +TY ++
Sbjct: 1641 HDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSP-----SEVTYELR 1695
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F ++ +G++S +LD E Y L + D N
Sbjct: 1696 EGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKI---RGSNMAGAFTDVMVVVDIIDEN 1752
Query: 1146 DNSPKF 1151
DN+P F
Sbjct: 1753 DNAPMF 1758
Score = 72.1 bits (169), Expect = 1e-11
Identities = 78/302 (25%), Positives = 127/302 (42%), Gaps = 32/302 (10%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS---------LTIPLT 133
V V + D+NDN P F Y V EL G + + I P L +
Sbjct: 2365 VVVNVSDINDNPPEFRQPQYEANVSELATCGH--LVLKVQAIDPDSRDTSRLEYLILSGN 2422
Query: 134 VPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
R I + D Y++ G DG F + PV + + +
Sbjct: 2423 QDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFR---ATVPVYI--NTTNANKY 2477
Query: 194 DKEFQLVI----MASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSV 249
EFQ + +A + +++ + AID+D G T+ Y +I+ + FS++
Sbjct: 2478 SPEFQQHLYEAELAENAMVGTKVI---DLLAIDKDSGPYGTIDYTIINKLASEKFSINP- 2533
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
NG + ++LD + N ++V A + A V+I L D NDN P+F+
Sbjct: 2534 NGQIATLQKLDRE---NSTERVIAIKVMARDGGG--RVAFCTVKIILTDENDNPPQFKAS 2588
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL---DDPKGAFSIDPRSGWLTVRNQ 366
Y +SI N+ V+QV+A D D+G+N + TY + D K I+P +G + V++
Sbjct: 2589 EYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDS 2648
Query: 367 TV 368
V
Sbjct: 2649 LV 2650
Score = 71.7 bits (168), Expect = 2e-11
Identities = 110/473 (23%), Positives = 193/473 (40%), Gaps = 38/473 (8%)
Query: 436 DEQLMSFVNVEVTLLDANDNNPVFVPS--NLYEFSMKSNAKVGTVIGKVKAVDPDLGQNG 493
+ L S V V +LD NDN P+F N+ S G V ++ A D D G NG
Sbjct: 1219 EPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVY-RLVASDLDEGLNG 1277
Query: 494 MVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRH-ALFVEASDQPANPSERRYSL 552
V Y ++ + F I+ TG VS + S G + L ++A+D P L
Sbjct: 1278 RVTYSIEDSYE----EAFSIDLVTGVVS-SNSTFTAGEYNILTIKATDSGQPPLSASVRL 1332
Query: 553 AVVTIEVTRGTKGNKPDIP-DFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLL 611
+ I R + IP F Y F V + VG I V + + + +
Sbjct: 1333 HIEWIPWPRPSS-----IPLAFDETYYSFTVMETDPVNHMVGVISVEG---RPGLFWFNI 1384
Query: 612 HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV-DVN 670
G ++ + F +E+ +G I + L R Y+ V + + + +I T + ++ ++N
Sbjct: 1385 SGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNL-TVEVTDGSR-TIATQVHIFMIANIN 1442
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
R L+ + + ++ G + ++ +I + ++ + I QD
Sbjct: 1443 HHRPQFLETRYEVRV--PQDTVPGVELLRV-----QAIDQDKGKSLIYTIHGSQDPGSAS 1495
Query: 731 AIAED---GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVF 787
D G + T LD + ++ + VTI++ED N +PP F
Sbjct: 1496 LFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRF 1555
Query: 788 EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTGVV 846
YE + + GTE+ ++A DAD G NA Y+L G + F+++ G++
Sbjct: 1556 TQLHYEASVPDTIAPGTELLQ---VRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGII 1612
Query: 847 KFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
+ LD+ + L++ A D G A +II + + + P F++ E
Sbjct: 1613 T-LAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSE 1664
Score = 71.3 bits (167), Expect = 2e-11
Identities = 92/357 (25%), Positives = 140/357 (39%), Gaps = 40/357 (11%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTD 1090
VRV ++DVND+ P FK Y +++ VL +V ATD D G N +TY T
Sbjct: 2056 VRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYT- 2114
Query: 1091 LPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
F I P G +S+ D + +KY L V+ARD G N ++P
Sbjct: 2115 -YFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVR---NKSNPL 2170
Query: 1151 FYAFDELLEWKHPEADELSNHNFESVMMIP-----VYKATIEENAPIGTTVAKVFANDTD 1205
F + + + PE L + P +Y EE + TT K
Sbjct: 2171 FQS--PYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVT 2228
Query: 1206 FIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELE 1265
+ + R LG S ++ +L+ V D P P F Y
Sbjct: 2229 GPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNP--------PTFSQLVYTTS 2280
Query: 1266 IEENVNAPVELVSLNLTEH--YENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDR 1323
I E + A ++ L ++ N + Y I+ E+ +D+ + F I+ G + V+ D
Sbjct: 2281 ISEGLPAQTPVIQLLASDQDSGRNRDVSYQIV-EDGSDVSKFFQINGSTGEMSTVQELDY 2339
Query: 1324 EVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF 1380
E + + V VRA + + L G T VVV + D+NDN P+F
Sbjct: 2340 EAQQHFHVKVRAMDK-------------GDPPLTGET----LVVVNVSDINDNPPEF 2379
Score = 70.1 bits (164), Expect = 6e-11
Identities = 66/223 (29%), Positives = 98/223 (43%), Gaps = 31/223 (13%)
Query: 992 FVINERHGHVIVARSLPPES--EFRLNI--SALDGGNLNDNISVRVFVKDVNDHFPVFKK 1047
F ++ R G + V SL E+ ++ L+I S +L+D +V V + DVN+H P F +
Sbjct: 3264 FRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQ 3323
Query: 1048 TWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGE 1107
Y+ V E V+ V ATD D N+++TY + + F I P G L V
Sbjct: 3324 DPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKA 3383
Query: 1108 LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE 1167
LDRE Y L + A D+G DVNDN P+F+ +
Sbjct: 3384 LDREQASSYSLKLRATDSG-QPPLHEDTDIAIQVADVNDNPPRFFQLN------------ 3430
Query: 1168 LSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNG 1210
Y T++EN+PIG+ V ++ +D D NG
Sbjct: 3431 --------------YSTTVQENSPIGSKVLQLILSDPDSPENG 3459
Score = 69.3 bits (162), Expect = 1e-10
Identities = 90/330 (27%), Positives = 149/330 (45%), Gaps = 67/330 (20%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIFK 142
V +++ DVND+ P F + Y V + + PI P + + +
Sbjct: 1858 VIIHVRDVNDSPPRFSEQIYEVAI--------------VGPIHPGMELLM---------- 1893
Query: 143 DIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALE------SSHKPVLL-LRKVLDYDAGDK 195
+RA D D S+V+YSI +GN D + S P L L + L A D
Sbjct: 1894 -VRASDED------SEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRKLTIRASDG 1946
Query: 196 EFQ---LVIMASGKRIHKEILFPEPIH--AIDQDLG-------VGA-------TLRYELI 236
+Q LV ++ + + K + F + ++ A+ ++L +GA TL Y L+
Sbjct: 1947 LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQGNHLNDTLSYFLL 2006
Query: 237 SGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
+G D +F + G L + + D E Q +T L V+ P + AQ V + +
Sbjct: 2007 NGTD--MFHMVQSAGVL-QTRGVAFDRE---QQDTHELAVEVRDNRTPQRVAQGLVRVSI 2060
Query: 297 LDLNDNLPEFE-VDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSID 355
D+NDN P+F+ + +Y I I + G + QV ATD+D G NG TY+ + F ID
Sbjct: 2061 EDVNDNPPKFKHLPYYTI-IQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYTYFRID 2119
Query: 356 PRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
P G ++++ D +A + +KV A++
Sbjct: 2120 PYLGDISLKKP--FDYQALNKYHLKVIARD 2147
Score = 68.1 bits (159), Expect = 2e-10
Identities = 109/462 (23%), Positives = 184/462 (39%), Gaps = 43/462 (9%)
Query: 489 LGQNGMVLYDLQRTSNLTITSPFKINPNTG---TVSVAESPILEGRHALFVEASDQPANP 545
LG G L D L T F + + G T VA + H L VE D N
Sbjct: 1990 LGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRD---NR 2046
Query: 546 SERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAF--EQ 603
+ +R + +V + + + P P F PY + G + Q+ D
Sbjct: 2047 TPQRVAQGLVRVSIE--DVNDNP--PKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTN 2102
Query: 604 NDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNAT 663
V+Y+ Y F ++ G I++ Y + +A ++ S+ +
Sbjct: 2103 GAVTYEFAEDYTY---FRIDPYLGDISLKKPFDYQALNKYHLKVIA-RDGGTPSLQSEEE 2158
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
V +V V ++ L + + + V EN I HT S G + + I +
Sbjct: 2159 V-LVTVRNKSNPLFQSPYYKV--RVPENIT--LYTPILHTQARSPEGL---RLIYNIVEE 2210
Query: 724 QDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIA-EFNKGVISGAGIYQVTIYIEDEND 782
+ + + G + PLD E + + TV A + G S A V + +ED ND
Sbjct: 2211 EPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEA---TVEVLVEDVND 2267
Query: 783 NPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM---FDV 839
NPP F Y I E T + + A+D D G N Y + +G ++ F +
Sbjct: 2268 NPPTFSQLVYTTSISEGLPAQTPVIQ---LLASDQDSGRNRDVSYQIVEDGSDVSKFFQI 2324
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
+ +TG + + LD E + + + + A D G L+ E +++ + D NDN PEF Q +
Sbjct: 2325 NGSTGEMSTV-QELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQ 2383
Query: 898 ENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFL 939
+ V ++L T G +++V+ + + D +L L L
Sbjct: 2384 YEANV-----SEL-ATCGHLVLKVQAIDPDSRDTSRLEYLIL 2419
Score = 65.7 bits (153), Expect = 1e-09
Identities = 44/138 (31%), Positives = 70/138 (50%), Gaps = 6/138 (4%)
Query: 231 LRYELISGNDRKLFSLDS--VNGSLFLE---KELDLDAEHNLQANTFVLQVQASQLNNPL 285
+RY +ISG+ +F + V FL K + + +++ L +QA++ L
Sbjct: 69 VRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLEL 128
Query: 286 KTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+ A RV + +LD ND P F Y ++I E++P + +V ATD D G+N EF Y
Sbjct: 129 E-ALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF 187
Query: 346 DDPKGAFSIDPRSGWLTV 363
+ F+I P SG +TV
Sbjct: 188 NTRSEMFAIHPTSGVVTV 205
Score = 65.7 bits (153), Expect = 1e-09
Identities = 45/130 (34%), Positives = 66/130 (50%), Gaps = 11/130 (8%)
Query: 231 LRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQA 290
L+Y L ++ F L++ G + K +D + Q + QAS +
Sbjct: 393 LQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTSPGQASTV--------- 443
Query: 291 RVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKG 350
V I+++D N++ P F Y+ ++ EN+P G SVL V ATD+D GENG TY + PK
Sbjct: 444 -VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKA 502
Query: 351 -AFSIDPRSG 359
FSIDP G
Sbjct: 503 LPFSIDPYLG 512
Score = 65.3 bits (152), Expect = 2e-09
Identities = 44/145 (30%), Positives = 73/145 (50%), Gaps = 8/145 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D L + + SGN F + V G L ++LD + + + +L+V
Sbjct: 1159 LDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENK-----DEHILEVT 1213
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLP--NGFSVLQVMATDKDQ 335
P + +RV + +LD+NDN P F +N+ + E L + V +++A+D D+
Sbjct: 1214 VLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDE 1273
Query: 336 GENGEFTYQLDDP-KGAFSIDPRSG 359
G NG TY ++D + AFSID +G
Sbjct: 1274 GLNGRVTYSIEDSYEEAFSIDLVTG 1298
Score = 65.3 bits (152), Expect = 2e-09
Identities = 45/164 (27%), Positives = 78/164 (47%), Gaps = 5/164 (3%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P IHA D D + L Y+++ K F +D G+L + E+D ++ + Q +V
Sbjct: 1784 PFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVH 1843
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ L P A+V I + D+ND+ P F Y ++IV + G +L V A+D+D
Sbjct: 1844 DQGSPVLFAP---RPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDED 1900
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLR 378
N ++ + + A +I P +G ++V N L ++R
Sbjct: 1901 SEVN--YSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRKLTIR 1942
Score = 64.5 bits (150), Expect = 3e-09
Identities = 64/218 (29%), Positives = 90/218 (41%), Gaps = 22/218 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PE++P GT + L+A D D G G++RY + F ++ G
Sbjct: 934 VPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMDGAH--------------GTFRVDLMTG 979
Query: 1000 HVIVARSLPPESEFRLNIS--ALDGGN---LNDNISVRVFVKDVND--HFPVFKKTWYNF 1052
+I+ R L E N+S A DGG V V V DVN+ H P F +
Sbjct: 980 ALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQG 1039
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRET 1112
V+E + + V A D D G + L YF++ F I+ TG++ LDRE
Sbjct: 1040 QVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREF 1099
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
Y LTV+A D G D NDN P+
Sbjct: 1100 ASYYWLTVLAVDRG-SVPLSSVTEVYIEVTDANDNPPQ 1136
Score = 64.5 bits (150), Expect = 3e-09
Identities = 109/480 (22%), Positives = 195/480 (40%), Gaps = 73/480 (15%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
II V P ++ A + IPE+IP+G+ I+ ++A+ ++ YE
Sbjct: 1647 IIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMS-----PSEVTYELREG---- 1697
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFV 1035
+ D + F +N G + + L E S ++L I + ++ V V +
Sbjct: 1698 ----NKDGV-----FSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVMVVVDI 1748
Query: 1036 KDVNDHFPVFKKTWYNFNVEEAQ-YTRRVLGK------VDATDADFGQNANLTYFIQPSD 1088
D ND+ P+F K+ + + EA ++ K + A+D+D N+ L Y I +
Sbjct: 1749 IDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPE 1808
Query: 1089 TDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGX-XXXXXXXXXXXXXXXDVNDN 1147
F+I P G L++ E+D E+ + V D G DVND+
Sbjct: 1809 ALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDS 1868
Query: 1148 SPKF--YAFDELLEWK-HPEADEL--SNHNFESVMMIPVYKATIEENAPIGTTVAKVFAN 1202
P+F ++ + HP + L + +S + + +E I +
Sbjct: 1869 PPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSIKTGNADEAVTIHPVTGSISVL 1928
Query: 1203 DTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYY 1262
+ F+G L + + + GL TA++ +++ V D+ D+ V Y
Sbjct: 1929 NPAFLGLSRKLTI--------RASDGL--YQDTALVKISLTQVLDKSLQFDQDV-----Y 1973
Query: 1263 ELEIEENVNAPVELVSLNLTEHYENFKMRYYILNENDT--DIRRTFVIDPRNGTLYLVRS 1320
++EN+ LV L ++ N + Y++LN D ++ V+ R G +
Sbjct: 1974 WAAVKENLQDRKALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQTR-GVAF---- 2028
Query: 1321 PDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF 1380
DRE +DT+E+ V + + V +G+ + V I+DVNDN PKF
Sbjct: 2029 -DREQQDTHELAVEVRDNR-----------TPQRVAQGLVR------VSIEDVNDNPPKF 2070
Score = 64.5 bits (150), Expect = 3e-09
Identities = 69/301 (22%), Positives = 129/301 (42%), Gaps = 17/301 (5%)
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
+V V V+DVND+ P F + Y ++ E + + ++ A+D D G+N +++Y I +
Sbjct: 2257 TVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGS 2316
Query: 1090 DLP--FEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDN 1147
D+ F+I+ TG +S ELD E + + + V A D G D+NDN
Sbjct: 2317 DVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKG-DPPLTGETLVVVNVSDINDN 2375
Query: 1148 SPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFI 1207
P+F EL+ V+ + + + + + + FI
Sbjct: 2376 PPEFRQ-----PQYEANVSELATCG-HLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFI 2429
Query: 1208 GNGNGLI-LYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSD-KPVFISRYYELE 1265
+ +G+I +++L ++ + L +S + TV + + P F YE E
Sbjct: 2430 NSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTNANKYSPEFQQHLYEAE 2489
Query: 1266 IEENVNAPVELVSLNLTEHYEN--FKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDR 1323
+ EN +++ L + + Y I+N+ ++ F I+P NG + ++ DR
Sbjct: 2490 LAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASE---KFSINP-NGQIATLQKLDR 2545
Query: 1324 E 1324
E
Sbjct: 2546 E 2546
Score = 63.7 bits (148), Expect = 5e-09
Identities = 51/157 (32%), Positives = 74/157 (47%), Gaps = 9/157 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G+ L+Y L +G FS++ G ++ LD E A+ + L V
Sbjct: 1054 VAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTG--MIQTLAPLDREF---ASYYWLTVL 1108
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A + ++ V IE+ D NDN P+ + SI E+ P G SVLQ+ A D D
Sbjct: 1109 AVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSS 1168
Query: 338 NGEFTYQLDDPK--GAFSIDPRSGWLTVRNQTVLDRE 372
G+ T+ + G F I P +G L+ Q LDRE
Sbjct: 1169 KGKLTFNITSGNYMGFFMIHPVTGLLSTAQQ--LDRE 1203
Score = 63.7 bits (148), Expect = 5e-09
Identities = 51/175 (29%), Positives = 82/175 (46%), Gaps = 12/175 (6%)
Query: 218 IHAIDQDLGVGATLRYELIS---GNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
+ AID+D G + Y L + N +LF++DS +G + +ELD + T+
Sbjct: 2819 VTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCET-----CQTYHF 2873
Query: 275 QVQASQLNNPLK-TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
V A ++ ++QA V++ + D NDN P F + Y S+VEN G V + D
Sbjct: 2874 HVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDA 2933
Query: 334 DQGE-NGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D E N + T + DP G F I + ++ LDRE + ++V A +
Sbjct: 2934 DISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASD 2988
Score = 62.9 bits (146), Expect = 9e-09
Identities = 46/139 (33%), Positives = 66/139 (47%), Gaps = 9/139 (6%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
+ G+ F + V + LD EH + ++L+V AS + A VEI
Sbjct: 2946 ITEGDPLGQFGISQVGDEWRISSRKTLDREHTAK---YLLRVTAS---DGKFQASVTVEI 2999
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKG-AFS 353
+LD+NDN P+ Y + E++ G +L+V ATD D N + TY L P F
Sbjct: 3000 FVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFK 3059
Query: 354 IDPRSGWLTVRNQTVLDRE 372
+DP +G LT T LDRE
Sbjct: 3060 LDPHTGELT--TLTALDRE 3076
Score = 62.1 bits (144), Expect = 1e-08
Identities = 75/300 (25%), Positives = 133/300 (44%), Gaps = 49/300 (16%)
Query: 129 TIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFAL-------------- 174
++P T+ G + + +RA D D+ N++VHYS++ GN +G F +
Sbjct: 1563 SVPDTIAPGTELLQ-VRAMDADRG--VNAEVHYSLLKGNSEGFFNINALLGIITLAQKLD 1619
Query: 175 ESSHKPVLLLRKVLDYDAGD-KEFQLVIM------ASGKRIHKEILF---PEPIHAIDQD 224
+++H P L K D + + VI+ S K F PE I
Sbjct: 1620 QANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPI 1679
Query: 225 LGVGAT----LRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQ 280
L V A + YEL GN +FS++S +G + +K+LD + + +++ L+++ S
Sbjct: 1680 LLVSAMSPSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHE-----KISSYQLKIRGSN 1734
Query: 281 LNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQ-------VMATDK 333
+ V ++++D NDN P F + I E P ++ + A+D
Sbjct: 1735 MAGAF--TDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDS 1792
Query: 334 DQGENGEFTYQLDDPKGA--FSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVV 391
D+ N Y++ +P+ F IDP G LT+ ++ +D E+ S + VY + V+
Sbjct: 1793 DKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSE--MDYESMPSFQFCVYVHDQGSPVL 1850
Score = 61.3 bits (142), Expect = 3e-08
Identities = 80/324 (24%), Positives = 126/324 (38%), Gaps = 31/324 (9%)
Query: 76 QISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGE-----KAFIFLIAPIGPSLTI 130
Q+S+ V V I D NDN P F Y +V E + GE K I+ +T
Sbjct: 2885 QLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTC 2944
Query: 131 PLTVPRGLTIFKDIRAFDRDKPNTPNS-----DVHYSIVSGNDDGHFALESSHKPVLLLR 185
+T L F + D + ++ + Y + DG F + + +L
Sbjct: 2945 YITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQASVTVEIFVL-- 3002
Query: 186 KVLDYDAGDKEFQLVIMASGKRIHKEIL---FPEPIHAIDQDLGVGATLRYELISGNDRK 242
D D Q + ++H+++ F + A D D A + Y L G
Sbjct: 3003 -----DVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSL-HGPGAH 3056
Query: 243 LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDN 302
F LD G L LD + + V + A + ++ QA + + + D+NDN
Sbjct: 3057 EFKLDPHTGELTTLTALDRERKD-------VFNLVAKATDGGGRSCQADITLHVEDVNDN 3109
Query: 303 LPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWL 361
P F +++ +N V V A D DQG N + Y L D +G FSID +G
Sbjct: 3110 APRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTG-- 3167
Query: 362 TVRNQTVLDREAHSSLRMKVYAKE 385
+R + L + L + V A +
Sbjct: 3168 VIRLEKPLQVRPQAPLELTVRASD 3191
Score = 60.1 bits (139), Expect = 6e-08
Identities = 94/420 (22%), Positives = 167/420 (39%), Gaps = 44/420 (10%)
Query: 939 LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERH 998
+I + G + +++A D D G NG + YEF +E Y YF I+
Sbjct: 2078 IIQDGTEPGDVLFQVSATDEDLGTNGAVTYEF-AEDYT--------------YFRIDPYL 2122
Query: 999 GHVIVARSLPPES--EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
G + + + ++ ++ L + A DGG + V V N P+F+ +Y V E
Sbjct: 2123 GDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVRNKSNPLFQSPYYKVRVPE 2182
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKY 1116
+ + T A + L Y I + + F TGVL+V G LD E++ K+
Sbjct: 2183 ---NITLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKH 2239
Query: 1117 ILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF------YAFDELLEWKHPEADELSN 1170
+ TV A D DVNDN P F + E L + P L++
Sbjct: 2240 VFTVRATD--TALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLAS 2297
Query: 1171 HNFESVMMIPVYKATIEENAPIGTTVAKVF-ANDTDFIGNGNGLILYSLPQ----RKNQQ 1225
+S V +E+ G+ V+K F N + + + Y Q +
Sbjct: 2298 DQ-DSGRNRDVSYQIVED----GSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAM 2352
Query: 1226 NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHY 1285
+ G P L+ +++V V+D+ D +P + + EL ++ V+ + +
Sbjct: 2353 DKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAID---PDSR 2409
Query: 1286 ENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
+ ++ Y IL+ N R F I+ +G + + + + +Y + V A + +P
Sbjct: 2410 DTSRLEYLILSGNQD---RHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVP 2466
Score = 58.8 bits (136), Expect = 1e-07
Identities = 52/173 (30%), Positives = 84/173 (48%), Gaps = 13/173 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGND---RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
+ AIDQD G +L Y + D LF LD +G L +LDL + + +T +
Sbjct: 1470 VQAIDQDKG--KSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPS--QHTLTV 1525
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
V+ ++ P+K V I + D N + P F Y S+ + + G +LQV A D D
Sbjct: 1526 MVRDQEI--PIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDAD 1583
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+G N E Y L + +G F+I+ G +T+ + LD+ H+ + V A++
Sbjct: 1584 RGVNAEVHYSLLKGNSEGFFNINALLGIITLAQK--LDQANHAPHTLTVKAED 1634
Score = 58.4 bits (135), Expect = 2e-07
Identities = 76/318 (23%), Positives = 129/318 (40%), Gaps = 27/318 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLT---VPRGL 138
+V V +EDVNDN P F Y ++ E P L + ++ V G
Sbjct: 2257 TVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGS 2316
Query: 139 TIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV----LLLRKVLDYDAGD 194
+ K + + ++ Y A++ P+ L++ V D +
Sbjct: 2317 DVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNP 2376
Query: 195 KEF-QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG-- 251
EF Q A+ + + AID D + L Y ++SGN + F ++S +G
Sbjct: 2377 PEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGII 2436
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
S+F + LD+ +NL+ ++ + A V I + N PEF+ Y
Sbjct: 2437 SMFNLCKKHLDSSYNLRVGA----------SDGVFRATVPVYINTTNANKYSPEFQQHLY 2486
Query: 312 NISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGA--FSIDPRSGWLTVRNQTVL 369
+ EN G V+ ++A DKD G G Y + + + FSI+P T++ L
Sbjct: 2487 EAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQIATLQK---L 2543
Query: 370 DREAHSS--LRMKVYAKE 385
DRE + + +KV A++
Sbjct: 2544 DRENSTERVIAIKVMARD 2561
Score = 56.8 bits (131), Expect = 6e-07
Identities = 46/167 (27%), Positives = 77/167 (46%), Gaps = 7/167 (4%)
Query: 992 FVINERHGHVIVARSLPPESE--FRLNISA--LDGGNLNDNISVRVFVKDVNDHFPVFKK 1047
F ++ G + V + + ES +++++ A L ++ +SV + V DVND+ PVF+
Sbjct: 2740 FSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEA 2799
Query: 1048 TWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQP---SDTDLPFEISPLTGVLSV 1104
Y + E + +V A D D G++ ++Y + S+ F I +G ++
Sbjct: 2800 DPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITT 2859
Query: 1105 NGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
ELD ET Y VVA D+G D NDN+P+F
Sbjct: 2860 LQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRF 2906
Score = 56.8 bits (131), Expect = 6e-07
Identities = 42/147 (28%), Positives = 69/147 (46%), Gaps = 7/147 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G A + Y L + FS+D+ G + LEK L + + L+ L V+
Sbjct: 3135 VFARDPDQGANAQVVYSLPDSAEGH-FSIDATTGVIRLEKPLQVRPQAPLE-----LTVR 3188
Query: 278 ASQLNNPLKTAQ-ARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
AS L P+ + V + ++ L D LP F +++ + E+ P G VLQ+ +
Sbjct: 3189 ASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGA 3248
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTV 363
E + + +G F +D R+G L V
Sbjct: 3249 EKTGYRVVSGNEQGRFRLDARTGILYV 3275
Score = 56.4 bits (130), Expect = 7e-07
Identities = 78/271 (28%), Positives = 104/271 (38%), Gaps = 44/271 (16%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I N+ + +I++ A D D G N + Y N P L D +E IN G
Sbjct: 2594 IQSNVSKDSPVIQVLAYDADEGQNADVTYSVN------PEDLVKDVIE------INPVTG 2641
Query: 1000 HVIVARSLPPESEFRLN--ISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
V V SL L+ I A DGG + N + VR+ V P F + Y F+
Sbjct: 2642 VVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAP 2701
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQP-SDTDLPFEISPLTGVLSVNGELDRETED 1114
E +G V A A +L P S+ D F + P TGV+ V +D E+
Sbjct: 2702 EDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTK 2761
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFE 1174
Y + V+A DVNDN P F EAD
Sbjct: 2762 LYQIDVMAHCL-QNTDVVSLVSVNIQVGDVNDNRPVF------------EADP------- 2801
Query: 1175 SVMMIPVYKATIEENAPIGTTVAKVFANDTD 1205
YKA + EN P+GT+V +V A D D
Sbjct: 2802 -------YKAVLTENMPVGTSVIQVTAIDKD 2825
Score = 55.2 bits (127), Expect = 2e-06
Identities = 37/107 (34%), Positives = 55/107 (51%), Gaps = 6/107 (5%)
Query: 744 LDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIG 803
L+RE RD Y T+I + + + + +V ++I D+ND P+F +Y I E+ +
Sbjct: 107 LNREVRDSY--TLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLK 164
Query: 804 TEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIG 850
+ I + ATDAD G NA F Y F EMF + +GVV G
Sbjct: 165 SPICK---VTATDADLGQNAEFYYA-FNTRSEMFAIHPTSGVVTVAG 207
Score = 54.8 bits (126), Expect = 2e-06
Identities = 50/190 (26%), Positives = 90/190 (47%), Gaps = 19/190 (10%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
EN +G I+ ++A D D LN I Y I ++L +F I+ + G +
Sbjct: 3332 ENALVGDVILTVSATDEDGPLNSDITYSL-----IGGNQLG--------HFTIHPKKGEL 3378
Query: 1002 IVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
VA++L E S + L + A D G L+++ + + V DVND+ P F + Y+ V+E
Sbjct: 3379 QVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQEN 3438
Query: 1058 QYTRRVLGKVDATDADFGQNA-NLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKY 1116
+ ++ +D D +N ++ I + F ++P +++ G L R ++ Y
Sbjct: 3439 SPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTAEG-LSRRAQEWY 3497
Query: 1117 ILTVVARDNG 1126
L + A D+G
Sbjct: 3498 QLQIQASDSG 3507
Score = 53.6 bits (123), Expect = 5e-06
Identities = 34/94 (36%), Positives = 51/94 (54%), Gaps = 2/94 (2%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTD 1090
V V + D ND P+F Y + E + + KV ATDAD GQNA Y+ + ++
Sbjct: 134 VVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEF-YYAFNTRSE 192
Query: 1091 LPFEISPLTGVLSVNGELDRETEDKYILTVVARD 1124
+ F I P +GV++V G+L+ K+ L V+A D
Sbjct: 193 M-FAIHPTSGVVTVAGKLNVTWRGKHELQVLAVD 225
Score = 53.2 bits (122), Expect = 7e-06
Identities = 42/126 (33%), Positives = 61/126 (48%), Gaps = 10/126 (7%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L + V V +LD ND P+F P + Y ++ + + + I KV A D DLGQN Y
Sbjct: 127 ELEALTRVVVHILDQNDLKPLFSPPS-YRVTISEDMPLKSPICKVTATDADLGQNAEFYY 185
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAE--SPILEGRHALFVEASDQPANPSERR--YSLA 553
S + F I+P +G V+VA + G+H L V A D+ SE SLA
Sbjct: 186 AFNTRSEM-----FAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLA 240
Query: 554 VVTIEV 559
+ + V
Sbjct: 241 ALVVHV 246
Score = 52.8 bits (121), Expect = 9e-06
Identities = 105/426 (24%), Positives = 171/426 (40%), Gaps = 55/426 (12%)
Query: 992 FVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVF-VKDVNDHFPVFKKT 1048
F I + G +++AR L S + L + DG V +F + ++N H P F +T
Sbjct: 1393 FDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIAT-QVHIFMIANINHHRPQFLET 1451
Query: 1049 WYNFNVEEAQYTRRVLGKVDATDADFGQNANLT-YFIQPSDTDLPFEISPLTGVLSVNGE 1107
Y V + L +V A D D G++ T + Q + F++ P +GVL G+
Sbjct: 1452 RYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGK 1511
Query: 1108 LDRET-EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEAD 1166
LD + ++ LTV+ RD D N + P+F L ++ D
Sbjct: 1512 LDLGSGPSQHTLTVMVRDQ-EIPIKRNFVWVTIHVEDGNLHPPRF----TQLHYEASVPD 1566
Query: 1167 ELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLI-LYSLPQRKNQQ 1225
++ ++ + A NA + ++ K N F N N L+ + +L Q+ +Q
Sbjct: 1567 TIAPGT--ELLQVRAMDADRGVNAEVHYSLLK--GNSEGFF-NINALLGIITLAQKLDQA 1621
Query: 1226 NLGLPSLSSTAILMVT-----VADVPDEVEMSDK--PVFISRYYELEIEEN--VNAPVEL 1276
N +L+ A + +A V V SD+ P+F Y +EI E+ V +P+ L
Sbjct: 1622 NHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILL 1681
Query: 1277 VSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAE 1336
VS Y L E + D F ++ +G + + D E +Y++ +R
Sbjct: 1682 VSAMSPSEVT------YELREGNKD--GVFSMNSYSGLISTQKKLDHEKISSYQLKIR-- 1731
Query: 1337 RQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAP 1396
++ T DV VVV I D NDN+P F V I AP
Sbjct: 1732 ---------------GSNMAGAFT--DVMVVVDIIDENDNAPMFLKST--FVGQISEAAP 1772
Query: 1397 FGYQVM 1402
+M
Sbjct: 1773 LYSMIM 1778
Score = 49.2 bits (112), Expect = 1e-04
Identities = 59/225 (26%), Positives = 95/225 (42%), Gaps = 20/225 (8%)
Query: 444 NVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTS 503
++ + + D NDN P F N Y +++ N+ +G+ + ++ DPD +NG Y + T
Sbjct: 3411 DIAIQVADVNDNPPRFFQLN-YSTTVQENSPIGSKVLQLILSDPDSPENGPP-YSFRITK 3468
Query: 504 NLTITSPFKINPNTGTVSVAE--SPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTR 561
S F++ P+ G + AE S + + L ++ASD P SL V + VT
Sbjct: 3469 GNN-GSAFRVTPD-GWLVTAEGLSRRAQEWYQLQIQASDSGIPPLS---SLTSVRVHVTE 3523
Query: 562 GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFA 621
+ P + VG + G VG+I D Q+ ++Y L G F+
Sbjct: 3524 QSHY----APSALPLEIFITVGEDEFQGGMVGKIHATDRDPQDTLTYSLAEEETLGRHFS 3579
Query: 622 VEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHV 666
V G I L R + Y F ++ + T A VHV
Sbjct: 3580 VGAPDGKIIAAQGLPRGH---YSFNVTV----SDGTFTTTAGVHV 3617
Score = 47.2 bits (107), Expect = 5e-04
Identities = 54/216 (25%), Positives = 86/216 (39%), Gaps = 24/216 (11%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
+N + T + + A D D G N Q+ Y +P S + +F I+ G +
Sbjct: 3124 DNTTVKTPVAVVFARDPDQGANAQVVYS------LPDS--------AEGHFSIDATTGVI 3169
Query: 1002 IVARSLP--PESEFRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFKKTWYNFNV-E 1055
+ + L P++ L + A D G L+ +V V V + D+ PVF T ++ V E
Sbjct: 3170 RLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPE 3229
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
+A VL T + Y + + F + TG+L VN LD ET K
Sbjct: 3230 DAPPGTEVLQLATLTRPGAEKTG---YRVVSGNEQGRFRLDARTGILYVNASLDFETSPK 3286
Query: 1116 YILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
Y L++ DVN++ P+F
Sbjct: 3287 YFLSIEC-SRKSSSSLSDVTTVMVNITDVNEHRPQF 3321
Score = 46.8 bits (106), Expect = 6e-04
Identities = 35/130 (26%), Positives = 67/130 (51%), Gaps = 11/130 (8%)
Query: 236 ISGNDRKL-FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
ISG D+ + F ++ GS+ + + LD N + L V+ + + + T Q + +
Sbjct: 1384 ISGGDKDMDFDIEKTTGSIVIARPLDTRRRSN-----YNLTVEVTDGSRTIAT-QVHIFM 1437
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFT-YQLDDPKGA-- 351
+ ++N + P+F Y + + ++ G +L+V A D+D+G++ +T + DP A
Sbjct: 1438 -IANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASL 1496
Query: 352 FSIDPRSGWL 361
F +DP SG L
Sbjct: 1497 FQLDPSSGVL 1506
Score = 44.4 bits (100), Expect = 0.003
Identities = 44/176 (25%), Positives = 75/176 (42%), Gaps = 29/176 (16%)
Query: 1231 SLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NF 1288
SLS +MV + DV + +P F Y + EN +++++ T+ N
Sbjct: 3300 SLSDVTTVMVNITDVNEH-----RPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNS 3354
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y ++ N F I P+ G L + ++ DRE +Y + +RA
Sbjct: 3355 DITYSLIGGNQLG---HFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQP------- 3404
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQL 1404
P+ ED + +++ DVNDN P+F N T + +P G +V+QL
Sbjct: 3405 -PLHEDT---------DIAIQVADVNDNPPRFFQLN--YSTTVQENSPIGSKVLQL 3448
Score = 41.5 bits (93), Expect = 0.022
Identities = 44/163 (26%), Positives = 69/163 (42%), Gaps = 28/163 (17%)
Query: 1226 NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL--TE 1283
+LG P SS +L V V D D P F Y+L I E+ + L +
Sbjct: 794 DLGTPQKSSWKLLTVNVKDWNDNA-----PRFPPGGYQLTISEDTEVGTTIAELTTKDAD 848
Query: 1284 HYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRE 1343
+N ++RY +L+ + F + P G L + DRE + Y + V A Q
Sbjct: 849 SEDNGRVRYTLLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKG- 902
Query: 1344 LPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPK-FTNGNR 1385
H ++ V + +++ ++DVNDNSP+ T NR
Sbjct: 903 --HQLFSVTD------------LIITLEDVNDNSPQCITEHNR 931
Score = 35.5 bits (78), Expect = 1.5
Identities = 18/39 (46%), Positives = 23/39 (58%), Gaps = 1/39 (2%)
Query: 1441 ATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAAL 1479
ATD+D+G NA+ Y N ++ FAI P SG V V L
Sbjct: 172 ATDADLGQNAEF-YYAFNTRSEMFAIHPTSGVVTVAGKL 209
Score = 35.5 bits (78), Expect = 1.5
Identities = 41/169 (24%), Positives = 71/169 (42%), Gaps = 13/169 (7%)
Query: 220 AIDQDLGVGATLRYELISGND--RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
A D D G A + Y ++ D + + ++ V G + ++ D+ L+ T ++
Sbjct: 2609 AYDADEGQNADVTYS-VNPEDLVKDVIEINPVTGVVKVK-----DSLVGLENQTLDFFIK 2662
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFS---VLQVMATDKD 334
A P + V ++++ +LP+F Y S E+LP G V V A D
Sbjct: 2663 AQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPV 2722
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
T + G FS+DP +G + VR +D E+ ++ V A
Sbjct: 2723 IYSLVRGTTPESNKDGVFSLDPDTGVIKVRKP--MDHESTKLYQIDVMA 2769
Score = 34.7 bits (76), Expect = 2.6
Identities = 18/47 (38%), Positives = 24/47 (51%)
Query: 1441 ATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARDAGRVF 1487
ATD D NA I Y + A F +DP +G + + AL R+ VF
Sbjct: 3035 ATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELTTLTALDRERKDVF 3081
Score = 34.3 bits (75), Expect = 3.4
Identities = 14/37 (37%), Positives = 21/37 (56%)
Query: 77 ISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
+ + +SV + + DVNDN P+F PY + E P G
Sbjct: 2777 VVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVG 2813
Score = 33.1 bits (72), Expect = 7.9
Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 1441 ATDSDIGINADIRYQIL-NEQAPRFAIDPVSGTVRVVAALARD 1482
ATD D +N+DI Y ++ Q F I P G ++V AL R+
Sbjct: 3345 ATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDRE 3387
>AY356402-1|AAR13653.1| 3222|Homo sapiens fat-like cadherin FATJ
protein protein.
Length = 3222
Score = 145 bits (351), Expect = 1e-33
Identities = 229/923 (24%), Positives = 385/923 (41%), Gaps = 119/923 (12%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S+ +++T+LD NDN P+F + + + N ++ V A+D D G NG + Y++
Sbjct: 949 SYEKLDITVLDVNDNAPIF-KEDPFISEILENLSPRKIL-TVSAMDKDSGPNGQLDYEIV 1006
Query: 501 RTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIE 558
N + + F IN TG + E + L +++SD+ +PS+ ++ I
Sbjct: 1007 ---NGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDK-GSPSQSTSVKVMINI- 1061
Query: 559 VTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGY---E 615
N P A V N +G +V ++ +D D+ + + Y +
Sbjct: 1062 --LDENDNAPRFSQIFSAH----VPENSPLGYTVTRVTTSD----EDIGINAISRYSIMD 1111
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGV 675
+PF + +G I + L+R + Y A ++ ++ T+ T+ V D+ND
Sbjct: 1112 ASLPFTINPSTGDIVISRPLNREDTDRYRIRVSA--HDSGWTVSTDVTIFVTDINDNAPR 1169
Query: 676 LLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED 735
+ ++ + E G+ + Q+F T+ G V + I +Q + A
Sbjct: 1170 FSRTSYYLDCPELTE--IGSKVTQVFATDPDE---GSNGQVFYFIKSQSEYFR--INATT 1222
Query: 736 GTIFTQKPLDREKR------DVYRMT-VIAEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
G IF ++ L + ++ R + ++ ++G S VTI I D NDN P F
Sbjct: 1223 GEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFL 1282
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ Y + +N K+GT K+ + D D G N+ Y + D + G K
Sbjct: 1283 KSKYFTPVTKNVKVGT--KLIRVTAIDDKDFGLNSEVEYFISN--------DNHLGKFK- 1331
Query: 849 IGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRET 908
LD DTG +S + LI D N N I +K + +
Sbjct: 1332 ----LDN-------------DTGWISVASSLI---SDLNQNF----FITVTAKDKGNPPL 1367
Query: 909 KLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRY 968
T T+ E +N + Q IPE+ IG+ + ++A D D+ +NG I+Y
Sbjct: 1368 SSQATVHITVTE---ENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKY 1424
Query: 969 EFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNL- 1025
+S + F IN G + +A++L E + + ISA+DGG +
Sbjct: 1425 SISSG-------------NEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVA 1471
Query: 1026 -NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI 1084
SV V V DVND+ PVF Y V E + + ++ATDAD G NA + Y +
Sbjct: 1472 RTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTV 1531
Query: 1085 QPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDV 1144
Q SD+DL F I P TGV++ G LD ET+ Y LTV A N
Sbjct: 1532 QSSDSDL-FVIDPNTGVITTQGFLDFETKQSYHLTVKA-FNVPDEERCSFATVNIQLKGT 1589
Query: 1145 NDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDT 1204
N+ P+F + +L + E+S + ++ V+ A+ + G +F N
Sbjct: 1590 NEYVPRFVS--KLYYF------EISEAAPKGTIVGEVF-ASDRDLGTDGEVHYLIFGNSR 1640
Query: 1205 D---FIGNGNGLILYS-LPQRKNQQNLGLPSLSST--AILMVTVADVPDEV---EMSDKP 1255
I G I S + R+ ++ + L L+ +I + +V V + +D P
Sbjct: 1641 KKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDANDPP 1700
Query: 1256 VFISRYYELEIEENV--NAPVELVSLNLTEHYENF-KMRYYILNENDTDIRRTFVIDPRN 1312
+F Y ++I E V V VS ++ ++ + Y+I + N+ F I+P+
Sbjct: 1701 IFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENG---AFSINPQT 1757
Query: 1313 GTLYLVRSPDREVKDTYEVIVRA 1335
G + + DRE Y + V A
Sbjct: 1758 GQITVTAELDRETLPIYNLSVLA 1780
Score = 130 bits (314), Expect = 4e-29
Identities = 130/477 (27%), Positives = 212/477 (44%), Gaps = 39/477 (8%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
VE+TL D NDN PVF P+++ + +++ N G+ I ++ A+D D G N +V Y + ++
Sbjct: 24 VEITLQDINDNPPVF-PTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGAD 82
Query: 505 LTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F+I+P +G + E R ++L V A D S+ R ++ V +
Sbjct: 83 ----DSFRIDPESGDLIATRRLDRERRSKYSLLVRA-DDGLQSSDMRINITVSDV----- 132
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVPF 620
P F Y F + + G+ V I +D+ +++Y + E+G+ F
Sbjct: 133 ----NDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGI-F 187
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ +GV + L Y Y V ++ +++DVND + +
Sbjct: 188 FLNPITGVFNLT-RLLDYEVQQYYILTVRAEDGGGQFTTIRVYFNILDVNDNPPIFSLNS 246
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+S + EN + +F N++ + + IA+ D + ++G +
Sbjct: 247 YSTSLM---ENLPVGSTVLVF--NVTDADDGINSQLTYSIAS-GDSLGQFTVDKNGVLKV 300
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISG--AGIYQVTIYIEDENDNPPVFEHATYEGFIME 798
K LDRE + Y + V + + QV+I + D NDNPP F +I E
Sbjct: 301 LKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLT-YIPE 359
Query: 799 NSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKK 858
N+ I T + +ATD D G N+ YTL F + G V+ G+ LDRE+
Sbjct: 360 NTPIDTVVFK---AQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGE-LDREEV 415
Query: 859 IMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
Y L++VA D G LSS E+++M+ D NDN P F Q KV I+ T L GT
Sbjct: 416 SNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQ--ALYKVEINENT-LTGT 469
Score = 128 bits (308), Expect = 2e-28
Identities = 129/471 (27%), Positives = 209/471 (44%), Gaps = 44/471 (9%)
Query: 442 FVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQR 501
+ +V V ++D NDN+PVF+ S+ Y ++ NA GT + + A D D G N ++ Y +Q
Sbjct: 1475 YCSVTVNVIDVNDNSPVFL-SDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQS 1533
Query: 502 TSNLTITSPFKINPNTGTVSVAESPILEGRHA--LFVEASDQPANPSERRYSLAVVTIEV 559
+ + F I+PNTG ++ E + + L V+A + P E R S A V I++
Sbjct: 1534 SD----SDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNV---PDEERCSFATVNIQL 1586
Query: 560 TRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN--DAFEQNDVSYDLLHGYEEG 617
KG +P F+ Y F + GT VG++ + D +V Y L+ G
Sbjct: 1587 ----KGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHY-LIFGNSRK 1641
Query: 618 VPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLL 677
F + +++G I V L R + +A N + A + V VN V +
Sbjct: 1642 KGFQINKKTGQIYVSGILDREKEERVSLKVLA----KNFGSIRGADIDEVTVN----VTV 1693
Query: 678 KGAHSPIIFHVK----ENSAGAAIGQIFHTNMSSIYGNGT----GNVRFLIANQQDVTDD 729
A+ P IF + + S G IG H S + + + + I + +
Sbjct: 1694 LDANDPPIFTLNIYSVQISEGVPIGT--HVTFVSAFDSDSIPSWSRFSYFIGSGNENGAF 1751
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
+ G I LDRE +Y ++V+A + G S G + + +ED NDN P+
Sbjct: 1752 SINPQTGQITVTAELDRETLPIYNLSVLA-VDSGTPSATGSASLLVTLEDINDNGPML-- 1808
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTN-ALFMYTLFGEGKEMFDVDENTGVVKF 848
EG +MEN + GT + +++TD D N F Y L G +T V
Sbjct: 1809 TVSEGEVMENKRPGTLVM---TLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTAGVLS 1865
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIE 897
+DRE+ + LS+V +D+G +SS + I + D+NDN + +E
Sbjct: 1866 TTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDNPSQSRTVE 1916
Score = 126 bits (303), Expect = 8e-28
Identities = 127/460 (27%), Positives = 202/460 (43%), Gaps = 32/460 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAV-DPDLGQNGMVLY 497
L+S V + ++D+NDN P F+ S Y + N KVGT + +V A+ D D G N V Y
Sbjct: 1261 LISETTVTINIVDSNDNAPQFLKSK-YFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEY 1319
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVE-ASDQPANPSERRYSLAVVT 556
+ ++L FK++ +TG +SVA S I + F+ + NP S A V
Sbjct: 1320 FISNDNHL---GKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPP--LSSQATVH 1374
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQI--RVNDAFEQNDVSYDLLHGY 614
I VT P+F + + + IG+ V + R DA + Y + G
Sbjct: 1375 ITVTE----ENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGN 1430
Query: 615 EEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQEN-ANLSIVTNATVHVVDVNDER 673
EEG+ FA+ +G++T+ L ++ A+ + + TV+V+DVND
Sbjct: 1431 EEGI-FAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNS 1489
Query: 674 GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIA 733
V L + P + EN+ + H N + +GT V D +
Sbjct: 1490 PVFLSDDYFPTVL---ENAPSGT--TVIHLNATDA-DSGTNAVIAYTVQSSDSDLFVIDP 1543
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
G I TQ LD E + Y +TV A FN V I ++ N+ P F Y
Sbjct: 1544 NTGVITTQGFLDFETKQSYHLTVKA-FNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYY 1602
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG-KEMFDVDENTGVVKFIGDS 852
I E + GT + + A+D D GT+ Y +FG K+ F +++ TG + ++
Sbjct: 1603 FEISEAAPKGTIV---GEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQI-YVSGI 1658
Query: 853 LDREKKIMYKLSLVARDTGGLS----SEAELIIMIGDEND 888
LDREK+ L ++A++ G + E + + + D ND
Sbjct: 1659 LDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDAND 1698
Score = 123 bits (297), Expect = 4e-27
Identities = 118/461 (25%), Positives = 192/461 (41%), Gaps = 35/461 (7%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S V + LLD NDN P F+ L + N + TV+ K +A DPD G N + Y L
Sbjct: 331 STAQVSIILLDVNDNPPTFLSPKLTY--IPENTPIDTVVFKAQATDPDSGPNSYIEYTLL 388
Query: 501 RTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIE 558
+ + F I G V + E + L V A+D+ + V+ ++
Sbjct: 389 NP----LGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLD 444
Query: 559 VTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGYEE 616
+ P F A Y+ + N GT + Q+ D E V Y +++G
Sbjct: 445 INDNN-------PIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNG-NT 496
Query: 617 GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNA-TVHVVDVNDERGV 675
F ++ +G ITV L R P Y A + T+ ++ ++D+ND V
Sbjct: 497 NQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPV 556
Query: 676 LLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED 735
SP +V EN + G+ + L +D + ++
Sbjct: 557 F---ELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNED--NAFTLSAS 611
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G + + LDRE ++ + + + A + G + G + + ++D NDN P F Y
Sbjct: 612 GELGVTQSLDRETKERFVLMITAT-DSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTT 670
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
I E++ GT++ ++ A+DAD NA+ + G G F ++ +TG + LDR
Sbjct: 671 IPEDAPTGTDVL---LVNASDADASKNAVI--RIIG-GNSQFTINPSTGQI-ITSALLDR 723
Query: 856 EKKIMYKLSLVARDTGG---LSSEAELIIMIGDENDNKPEF 893
E K Y L +V D G LSS +++ + D NDN P F
Sbjct: 724 ETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRF 764
Score = 118 bits (284), Expect = 2e-25
Identities = 122/464 (26%), Positives = 205/464 (44%), Gaps = 38/464 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + +T+ D ND+ P F +Y F + + G+++ + A D D G NG + Y +
Sbjct: 121 SDMRINITVSDVNDHTPKF-SRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVN 179
Query: 501 RTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIE 558
I F +NP TG ++ E + + L V A D + R ++ +
Sbjct: 180 EDDEDGI---FFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTTIRVYFNILDVN 236
Query: 559 VTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGYEE 616
+ P P F Y + N+ +G++V V DA + + ++Y + G
Sbjct: 237 -------DNP--PIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSL 287
Query: 617 GVPFAVEERSGVITVVDDLSRYNRPMYDF--EAVALQENANLSIVTNATVHVV--DVNDE 672
G F V+ ++GV+ V+ L R ++ Y+ + L + + A V ++ DVND
Sbjct: 288 G-QFTVD-KNGVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDN 345
Query: 673 RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI 732
L SP + ++ EN+ + +F + + + + N I
Sbjct: 346 PPTFL----SPKLTYIPENTPIDTV--VFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGT 399
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
DG + LDRE+ Y +TV+A +KG S + +V + + D NDN P+F A Y
Sbjct: 400 I-DGEVRLTGELDREEVSNYTLTVVAT-DKGQPSLSSSTEVVVMVLDINDNNPIFAQALY 457
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTGVVKFIGD 851
+ I EN+ GT+I + A D DEGTN Y + G + F +D TG + +
Sbjct: 458 KVEINENTLTGTDIIQ---VFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAIT-VAK 513
Query: 852 SLDREKKIMYKLSLVARDTGGL--SSEAELIIMIGDENDNKPEF 893
LDREK Y L++ A D G + + + I++ D ND P F
Sbjct: 514 PLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVF 557
Score = 117 bits (282), Expect = 3e-25
Identities = 113/419 (26%), Positives = 183/419 (43%), Gaps = 33/419 (7%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L S V V +LD NDNNP+F + LY+ + N GT I +V A D D G NG V Y
Sbjct: 432 LSSSTEVVVMVLDINDNNPIFAQA-LYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYG 490
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVT 556
+ N F+I+ TG ++VA+ E + L V+A+D+ + P ++++V
Sbjct: 491 IV---NGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVL 547
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVG-IGTSVGQI--RVNDAFEQNDVSYDLLHG 613
+++ +P F +PY V N+G + ++ Q+ R +D + +SY L G
Sbjct: 548 LDIN-------DFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGG 600
Query: 614 YEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV--DVND 671
E+ F + SG + V L R + + A ++ + ++ T++V+ DVND
Sbjct: 601 NEDNA-FTLSA-SGELGVTQSLDRETKERFVLMITAT-DSGSPALTGTGTINVIVDDVND 657
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
A+ I ++ G + N S + +R + N Q +
Sbjct: 658 NVPTFASKAYFTTI--PEDAPTGT---DVLLVNASDADASKNAVIRIIGGNSQFTINP-- 710
Query: 732 IAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
G I T LDRE +D Y + V+ + V + + D NDNPP F+H
Sbjct: 711 --STGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHP 768
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIG 850
Y I + G+ + + TDAD G N+ Y+L G E F +D G + G
Sbjct: 769 YVTHIPSPTLPGSFVFA---VTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAG 824
Score = 108 bits (259), Expect = 2e-22
Identities = 132/485 (27%), Positives = 199/485 (41%), Gaps = 69/485 (14%)
Query: 929 LDVDQLGPLFL------IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLS 982
LDV+ P FL IPEN PI T + K A D DSG N I Y + + +K S
Sbjct: 340 LDVNDNPPTFLSPKLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPL---GNKFS 396
Query: 983 ADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG--NLNDNISVRVFVKDV 1038
++ G V + L E S + L + A D G +L+ + V V V D+
Sbjct: 397 IGTID-----------GEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDI 445
Query: 1039 NDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPL 1098
ND+ P+F + Y + E T + +V A D D G N + Y I +T+ F I +
Sbjct: 446 NDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSV 505
Query: 1099 TGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELL 1158
TG ++V LDRE Y LTV A D G D+ND P F EL
Sbjct: 506 TGAITVAKPLDREKTPTYHLTVQATDRG-STPRTDTSTVSIVLLDINDFVPVF----ELS 560
Query: 1159 EWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGL--ILY 1216
+ + L +++ + N+ + + V D F + +G +
Sbjct: 561 PYSVNVPENLGTLP-RTILQVVARDDDRGSNSKL-SYVLFGGNEDNAFTLSASGELGVTQ 618
Query: 1217 SLPQRKNQQ--------NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEE 1268
SL + ++ + G P+L+ T + V V DV D V P F S+ Y I E
Sbjct: 619 SLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNV-----PTFASKAYFTTIPE 673
Query: 1269 NVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDT 1328
+ +++ +N ++ + I+ N F I+P G + DRE KD
Sbjct: 674 DAPTGTDVLLVNASDADASKNAVIRIIGGNS-----QFTINPSTGQIITSALLDRETKDN 728
Query: 1329 YEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLV 1388
Y ++V S E P++ V+V + DVNDN P+F + P V
Sbjct: 729 YTLVVVCS-DAGSPE------PLSS---------STSVLVTVTDVNDNPPRFQ--HHPYV 770
Query: 1389 TAIPT 1393
T IP+
Sbjct: 771 THIPS 775
Score = 105 bits (251), Expect = 2e-21
Identities = 124/455 (27%), Positives = 197/455 (43%), Gaps = 63/455 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ ENI G+ I++L A+D D G N + Y S AD F I+ G
Sbjct: 47 VEENIGDGSKIMQLTAMDADEGANALVTYTIIS---------GADDS-----FRIDPESG 92
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+I R L E S++ L + A DG +D + + + V DVNDH P F + Y+F++ E
Sbjct: 93 DLIATRRLDRERRSKYSLLVRADDGLQSSD-MRINITVSDVNDHTPKFSRPVYSFDIPED 151
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYI 1117
++ + ATD D G N +TY + D D F ++P+TGV ++ LD E + YI
Sbjct: 152 TIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYI 211
Query: 1118 LTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVM 1177
LTV A D G DVNDN P F S +++ + +
Sbjct: 212 LTVRAEDGG---GQFTTIRVYFNILDVNDNPPIF-----------------SLNSYSTSL 251
Query: 1178 MIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAI 1237
M EN P+G+TV VF N TD N + YS+ + +LG ++ +
Sbjct: 252 M---------ENLPVGSTVL-VF-NVTDADDGINSQLTYSI---ASGDSLGQFTVDKNGV 297
Query: 1238 LMVTVADVPDEVEMSDKPVFISRYYELEIEE-NVNAPVELVSLNLTEHYENF---KMRYY 1293
L V A + + V + ++ A V ++ L++ ++ F K+ Y
Sbjct: 298 LKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTYI 357
Query: 1294 ILNEN-DTDIRRTFVIDPRNG----TLYLVRSP--DREVKDTYEVIVRAERQKYSRELP- 1345
N DT + + DP +G Y + +P ++ T + VR + E+
Sbjct: 358 PENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGELDREEVSN 417
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF 1380
+ + VA D + +VVV + D+NDN+P F
Sbjct: 418 YTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIF 452
Score = 103 bits (248), Expect = 4e-21
Identities = 119/461 (25%), Positives = 187/461 (40%), Gaps = 32/461 (6%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E L S +V VT+ D NDN P F + Y + S G+ + V D D+G N +
Sbjct: 742 EPLSSSTSVLVTVTDVNDNPPRF-QHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELH 800
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALF-VEASDQPANPSERRYSLAVV 555
Y L + + F I+P G + +A P+ F V D + P + V
Sbjct: 801 YSLSGRN----SEKFHIDPLRGAI-MAAGPLNGASEVTFSVHVKDGGSFP---KTDSTTV 852
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
T+ NK D P F N + + V I + +SY + G
Sbjct: 853 TVRFV-----NKADFPKVRAKEQTFMFPENQPVSSLVTTI-TGSSLRGEPMSYYIASG-N 905
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQEN-ANLSIVTNATVHVVDVNDERG 674
G F +++ +G +++ L Y A S + V+DVND
Sbjct: 906 LGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAP 965
Query: 675 VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAE 734
+ P I + EN + I + + S G + + I N
Sbjct: 966 IF---KEDPFISEILENLSPRKILTVSAMDKDS---GPNGQLDYEIVNGNMENSFSINHA 1019
Query: 735 DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEG 794
G I + +PLDREK Y +T I +KG S + +V I I DENDN P F +
Sbjct: 1020 TGEIRSVRPLDREKVSHYVLT-IKSSDKGSPSQSTSVKVMINILDENDNAPRFSQ-IFSA 1077
Query: 795 FIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLD 854
+ ENS +G + + +D D G NA+ Y++ + F ++ +TG + I L+
Sbjct: 1078 HVPENSPLGYTVTR---VTTSDEDIGINAISRYSIM-DASLPFTINPSTGDI-VISRPLN 1132
Query: 855 REKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQ 895
RE Y++ + A D+G S ++ I + D NDN P F++
Sbjct: 1133 REDTDRYRIRVSAHDSGWTVS-TDVTIFVTDINDNAPRFSR 1172
Score = 102 bits (245), Expect = 9e-21
Identities = 99/351 (28%), Positives = 160/351 (45%), Gaps = 33/351 (9%)
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND--VSYDLL 611
V +E+T + P P F + V N+G G+ + Q+ DA E + V+Y ++
Sbjct: 21 VFIVEITLQDINDNP--PVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTII 78
Query: 612 HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVND 671
G ++ F ++ SG + L R R Y A + + N TV DVND
Sbjct: 79 SGADDS--FRIDPESGDLIATRRLDRERRSKYSLLVRADDGLQSSDMRINITVS--DVND 134
Query: 672 ERGVLLKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
+ +S F + E++ G+ + I T+ S G + +++ +D D I
Sbjct: 135 HTPKFSRPVYS---FDIPEDTIPGSLVAAILATDDDS---GVNGEITYIV--NEDDEDGI 186
Query: 731 AIAED--GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
G + LD E + Y +TV AE G + +Y I D NDNPP+F
Sbjct: 187 FFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTTIRVY---FNILDVNDNPPIFS 243
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL-FGEGKEMFDVDENTGVVK 847
+Y +MEN +G+ + + N+ TDAD+G N+ Y++ G+ F VD+N GV+K
Sbjct: 244 LNSYSTSLMENLPVGSTVLVFNV---TDADDGINSQLTYSIASGDSLGQFTVDKN-GVLK 299
Query: 848 FIGDSLDREKKIMYKLSLVARD-----TGGLSSEAELIIMIGDENDNKPEF 893
+ +LDRE + Y L + D +S A++ I++ D NDN P F
Sbjct: 300 VL-KALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTF 349
Score = 101 bits (241), Expect = 3e-20
Identities = 102/342 (29%), Positives = 166/342 (48%), Gaps = 30/342 (8%)
Query: 66 DLVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP-- 123
DL +I A ++ ++ V++ + DVNDN P FL +P + E TP F
Sbjct: 320 DLPQIPA--SRFTSTAQVSIILLDVNDNPPTFL-SPKLTYIPENTPIDTVVFKAQATDPD 376
Query: 124 IGPSLTIPLTVPRGLTIFKDIRAFDRDKPNTPNSD----VHYSI-VSGNDDGHFALESSH 178
GP+ I T+ L I D + T D +Y++ V D G +L SS
Sbjct: 377 SGPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSST 436
Query: 179 KPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPI---HAIDQDLGVGATLRYEL 235
+ V++ VLD + + F + I++ L I A D D G +RY +
Sbjct: 437 EVVVM---VLDINDNNPIFAQALYKV--EINENTLTGTDIIQVFAADGDEGTNGQVRYGI 491
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIE 295
++GN + F +DSV G++ + K LD + + T+ L VQA+ + +T + V I
Sbjct: 492 VNGNTNQEFRIDSVTGAITVAKPLDRE-----KTPTYHLTVQATDRGSTPRTDTSTVSIV 546
Query: 296 LLDLNDNLPEFEVDFYNISIVENLPN-GFSVLQVMATDKDQGENGEFTYQL--DDPKGAF 352
LLD+ND +P FE+ Y++++ ENL ++LQV+A D D+G N + +Y L + AF
Sbjct: 547 LLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAF 606
Query: 353 SIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKET-NPSVVGT 393
++ SG L V LDRE + + A ++ +P++ GT
Sbjct: 607 TLS-ASGELGVTQS--LDRETKERFVLMITATDSGSPALTGT 645
Score = 100 bits (239), Expect = 5e-20
Identities = 118/414 (28%), Positives = 175/414 (42%), Gaps = 46/414 (11%)
Query: 938 FLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINER 997
F IPE+ G+ + + A D DSG+NG+I Y N + D + F +N
Sbjct: 146 FDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNED--------DEDGI-----FFLNPI 192
Query: 998 HGHVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
G + R L E + + L + A DGG I V + DVND+ P+F Y+ ++
Sbjct: 193 TGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTTIRVYFNILDVNDNPPIFSLNSYSTSLM 252
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E + + TDAD G N+ LTY I D+ F + GVL V LDRE++
Sbjct: 253 ENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVDK-NGVLKVLKALDRESQSF 311
Query: 1116 YILTVVARD--NGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNF 1173
Y L V D DVNDN P F L + PE + F
Sbjct: 312 YNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTF--LSPKLTY-IPENTPIDTVVF 368
Query: 1174 ESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLI-LYSLPQRKNQQNL----- 1227
++ P N+ I T+ N IG +G + L R+ N
Sbjct: 369 KAQATDP----DSGPNSYIEYTLLNPLGNKFS-IGTIDGEVRLTGELDREEVSNYTLTVV 423
Query: 1228 ----GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTE 1283
G PSLSS+ ++V V D+ D + P+F Y++EI EN +++ + +
Sbjct: 424 ATDKGQPSLSSSTEVVVMVLDIND-----NNPIFAQALYKVEINENTLTGTDIIQVFAAD 478
Query: 1284 HYE--NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
E N ++RY I+N N + F ID G + + + DRE TY + V+A
Sbjct: 479 GDEGTNGQVRYGIVNGN---TNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQA 529
Score = 93.5 bits (222), Expect = 5e-18
Identities = 101/356 (28%), Positives = 155/356 (43%), Gaps = 26/356 (7%)
Query: 436 DEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMV 495
DE+ SF V + L N+ P FV S LY F + A GT++G+V A D DLG +G V
Sbjct: 1573 DEERCSFATVNIQLKGTNEYVPRFV-SKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEV 1631
Query: 496 LYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPAN-PSERRYSLAV 554
Y + S F+IN TG + V S IL+ V N S R +
Sbjct: 1632 HYLIFGNSR---KKGFQINKKTGQIYV--SGILDREKEERVSLKVLAKNFGSIRGADIDE 1686
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAF---EQNDVSYDLL 611
VT+ VT N P P F Y + V IGT V + D+ + SY +
Sbjct: 1687 VTVNVT-VLDANDP--PIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIG 1743
Query: 612 HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV--DV 669
G E G F++ ++G ITV +L R P+Y+ +A+ ++ S +A++ V D+
Sbjct: 1744 SGNENGA-FSINPQTGQITVTAELDRETLPIYNLSVLAV-DSGTPSATGSASLLVTLEDI 1801
Query: 670 NDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
ND G +L + V EN + + + N G + + + T
Sbjct: 1802 ND-NGPMLTVSEG----EVMENKRPGTLVMTLQSTDPDLPPN-QGPFTYYLLSTGPATSY 1855
Query: 730 IAIAEDGTIFTQKPLDREK-RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
+++ G + T + +DRE+ D Y V + +S G +T+ D+NDNP
Sbjct: 1856 FSLSTAGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVI--DQNDNP 1909
Score = 88.2 bits (209), Expect = 2e-16
Identities = 118/460 (25%), Positives = 194/460 (42%), Gaps = 41/460 (8%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
+ V + D NDN P F S Y ++ +A GT + V A D D +N ++
Sbjct: 648 INVIVDDVNDNVPTFA-SKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRI------- 699
Query: 505 LTITSPFKINPNTGTV--SVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
+ S F INP+TG + S + + L V SD A E S V + VT
Sbjct: 700 IGGNSQFTINPSTGQIITSALLDRETKDNYTLVVVCSD--AGSPEPLSSSTSVLVTVT-- 755
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAF--EQNDVSYDLLHGYEEGVPF 620
+ P P F PY + S G+ V + V DA +++ Y L E F
Sbjct: 756 DVNDNP--PRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSE--KF 811
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
++ G I L+ + + +V +++ + + TV V VN ++
Sbjct: 812 HIDPLRGAIMAAGPLNGASEVTF---SVHVKDGGSFPKTDSTTVTVRFVNKADFPKVRAK 868
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAE-DGTIF 739
+F EN +++ + SS+ G + + IA+ ++ + I + G +
Sbjct: 869 EQTFMF--PENQPVSSL--VTTITGSSLRGEP---MSYYIASG-NLGNTFQIDQLTGQVS 920
Query: 740 TQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMEN 799
+PLD EK Y + + A + G + ++ I + D NDN P+F+ + I+EN
Sbjct: 921 ISQPLDFEKIQKYVVWIEAR-DGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILEN 979
Query: 800 SKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTGVVKFIGDSLDREKK 858
+ + A D D G N Y + G + F ++ TG ++ + LDREK
Sbjct: 980 LSPRKILT----VSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRP-LDREKV 1034
Query: 859 IMYKLSLVARDTGGLSSEAELIIMIG--DENDNKPEFNQI 896
Y L++ + D G S + +MI DENDN P F+QI
Sbjct: 1035 SHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQI 1074
Score = 87.0 bits (206), Expect = 5e-16
Identities = 83/312 (26%), Positives = 134/312 (42%), Gaps = 19/312 (6%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+VT+ I D NDN P FL + Y V + G K I + A + V ++
Sbjct: 1266 TVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTK-LIRVTAIDDKDFGLNSEVEYFISND 1324
Query: 142 KDIRAFDRDKPNTPNSDVHYSIVSGNDDGHF----ALESSHKPV----LLLRKVLDYDAG 193
+ F D +T V S++S + F A + + P+ + V + +
Sbjct: 1325 NHLGKFKLDN-DTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYH 1383
Query: 194 DKEF-QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGS 252
EF Q + A+ H + A D+D + ++Y + SGN+ +F+++S G
Sbjct: 1384 TPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGI 1443
Query: 253 LFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN 312
L L K LD + + + A +T V + ++D+NDN P F D Y
Sbjct: 1444 LTLAKALDYEL-----CQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYF 1498
Query: 313 ISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTVLDR 371
+++EN P+G +V+ + ATD D G N Y + F IDP +G +T Q LD
Sbjct: 1499 PTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVIT--TQGFLDF 1556
Query: 372 EAHSSLRMKVYA 383
E S + V A
Sbjct: 1557 ETKQSYHLTVKA 1568
Score = 86.2 bits (204), Expect = 8e-16
Identities = 50/173 (28%), Positives = 92/173 (53%), Gaps = 8/173 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D+D G L YE+++GN FS++ G + + LD + + + +VL ++
Sbjct: 988 VSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDRE-----KVSHYVLTIK 1042
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
+S +P ++ +V I +LD NDN P F ++ + EN P G++V +V +D+D G
Sbjct: 1043 SSDKGSPSQSTSVKVMINILDENDNAPRFS-QIFSAHVPENSPLGYTVTRVTTSDEDIGI 1101
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSV 390
N Y + D F+I+P +G + + L+RE R++V A ++ +V
Sbjct: 1102 NAISRYSIMDASLPFTINPSTGDIVISRP--LNREDTDRYRIRVSAHDSGWTV 1152
Score = 85.8 bits (203), Expect = 1e-15
Identities = 88/330 (26%), Positives = 146/330 (44%), Gaps = 28/330 (8%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIF--LIAPIGPSLTIPLTVPRGLTI 140
V + ++D+NDN P+F +TV+E G K + A G + + T+ G
Sbjct: 24 VEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADD 83
Query: 141 FKDIRAFDRDKPNTPNSDVH----YSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKE 196
I D T D YS++ DDG L+SS + + V D + +
Sbjct: 84 SFRIDPESGDLIATRRLDRERRSKYSLLVRADDG---LQSSDMRINIT--VSDVNDHTPK 138
Query: 197 FQLVIMASGKRIHKEILFPEPIHAI---DQDLGVGATLRYELISGNDRKLFSLDSVNGSL 253
F + + I ++ + + AI D D GV + Y + ++ +F L+ + G
Sbjct: 139 FSRPVYSFD--IPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVF 196
Query: 254 FLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNI 313
L + LD + + ++L V+A T RV +LD+NDN P F ++ Y+
Sbjct: 197 NLTRLLDYEVQQY-----YILTVRAEDGGGQFTTI--RVYFNILDVNDNPPIFSLNSYST 249
Query: 314 SIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDR 371
S++ENLP G +VL TD D G N + TY + D G F++D ++G L V LDR
Sbjct: 250 SLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVD-KNGVLKVLK--ALDR 306
Query: 372 EAHSSLRMKVYAKETNPSVVGTFADSQRIA 401
E+ S + V + F + +++
Sbjct: 307 ESQSFYNLVVQVHDLPQIPASRFTSTAQVS 336
Score = 81.4 bits (192), Expect = 2e-14
Identities = 82/329 (24%), Positives = 139/329 (42%), Gaps = 23/329 (6%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP--I 124
+V G +S+ V V + D+NDN PIF Y V ++E T TG A
Sbjct: 422 VVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDE 481
Query: 125 GPSLTIPLTVPRGLT-----IFKDIRAFDRDKP-NTPNSDVHYSIVSGNDDGHFALESSH 178
G + + + G T I A KP + + ++ V D G +
Sbjct: 482 GTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTS 541
Query: 179 KPVLLLRKVLDYDAGDK--EFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELI 236
++L + D+ + + + + + + + IL + A D D G + L Y L
Sbjct: 542 TVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTIL---QVVARDDDRGSNSKLSYVLF 598
Query: 237 SGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
GN+ F+L S +G L + + LD + + FVL + A+ +P T + + +
Sbjct: 599 GGNEDNAFTL-SASGELGVTQSLDRETKER-----FVLMITATDSGSPALTGTGTINVIV 652
Query: 297 LDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDP 356
D+NDN+P F Y +I E+ P G VL V A+D D +N ++ F+I+P
Sbjct: 653 DDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNA--VIRIIGGNSQFTINP 710
Query: 357 RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+G + +LDRE + + V +
Sbjct: 711 STG--QIITSALLDRETKDNYTLVVVCSD 737
Score = 80.2 bits (189), Expect = 5e-14
Identities = 84/314 (26%), Positives = 140/314 (44%), Gaps = 25/314 (7%)
Query: 77 ISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI--APIGPSLTIPLTV 134
+S+ SV V + DVNDN P F PY + T G F + A IGP+ + ++
Sbjct: 744 LSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSL 803
Query: 135 P-RGLTIFK--DIR-AFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDY 190
R F +R A P S+V +S V D G F S + D+
Sbjct: 804 SGRNSEKFHIDPLRGAIMAAGPLNGASEVTFS-VHVKDGGSFPKTDSTTVTVRFVNKADF 862
Query: 191 DAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVN 250
+ Q + + + + I G + Y + SGN F +D +
Sbjct: 863 PKVRAKEQTFMFPENQPVSSLVT------TITGSSLRGEPMSYYIASGNLGNTFQIDQLT 916
Query: 251 GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDF 310
G + + + LD + + +V+ ++A P ++ +++I +LD+NDN P F+ D
Sbjct: 917 GQVSISQPLDFE-----KIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDP 971
Query: 311 YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTV 368
+ I+ENL + +L V A DKD G NG+ Y++ + + +FSI+ +G +R+
Sbjct: 972 FISEILENL-SPRKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATG--EIRSVRP 1028
Query: 369 LDRE--AHSSLRMK 380
LDRE +H L +K
Sbjct: 1029 LDREKVSHYVLTIK 1042
Score = 80.2 bits (189), Expect = 5e-14
Identities = 70/234 (29%), Positives = 111/234 (47%), Gaps = 23/234 (9%)
Query: 938 FLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINER 997
F I E P GT + ++ A D D G +G++ Y + S+ K+ F IN++
Sbjct: 1603 FEISEAAPKGTIVGEVFASDRDLGTDGEVHY-----LIFGNSR--------KKGFQINKK 1649
Query: 998 HGHVIVARSLPPESEFRLNISAL--DGGNLN----DNISVRVFVKDVNDHFPVFKKTWYN 1051
G + V+ L E E R+++ L + G++ D ++V V V D ND P+F Y+
Sbjct: 1650 TGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDANDP-PIFTLNIYS 1708
Query: 1052 FNVEEAQYTRRVLGKVDATDADFGQN-ANLTYFIQPSDTDLPFEISPLTGVLSVNGELDR 1110
+ E + V A D+D + + +YFI + + F I+P TG ++V ELDR
Sbjct: 1709 VQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDR 1768
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFD-ELLEWKHP 1163
ET Y L+V+A D+G D+NDN P + E++E K P
Sbjct: 1769 ETLPIYNLSVLAVDSG-TPSATGSASLLVTLEDINDNGPMLTVSEGEVMENKRP 1821
Score = 79.8 bits (188), Expect = 7e-14
Identities = 119/481 (24%), Positives = 193/481 (40%), Gaps = 75/481 (15%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPE+ P GT ++ +NA D D+ N IR + F IN G
Sbjct: 671 IPEDAPTGTDVLLVNASDADASKNAVIRI-----------------IGGNSQFTINPSTG 713
Query: 1000 HVIVARSLPPESE--FRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFKKTWYNFNV 1054
+I + L E++ + L + D G+ L+ + SV V V DVND+ P F+ Y ++
Sbjct: 714 QIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHI 773
Query: 1055 EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETED 1114
+ V TDAD G N+ L Y + +++ F I PL G + G L+ +E
Sbjct: 774 PSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSE-KFHIDPLRGAIMAAGPLNGASEV 832
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFE 1174
+ +V +D G + PK A ++ + PE +S+
Sbjct: 833 TF--SVHVKDGGSFPKTDSTTVTVRFVNKA--DFPKVRAKEQ--TFMFPENQPVSS---- 882
Query: 1175 SVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQ--RKNQQNL----- 1227
++ + P+ +A +T I G + S P K Q+ +
Sbjct: 883 ---LVTTITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEA 939
Query: 1228 ---GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVN-APVELVSLNLTE 1283
G P SS L +TV DV D + + FIS EI EN++ + VS +
Sbjct: 940 RDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFIS-----EILENLSPRKILTVSAMDKD 994
Query: 1284 HYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRE 1343
N ++ Y I+N N + +F I+ G + VR DRE Y + ++
Sbjct: 995 SGPNGQLDYEIVNGN---MENSFSINHATGEIRSVRPLDREKVSHYVLTIK--------- 1042
Query: 1344 LPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQ 1403
+ D VKV++ I D NDN+P+F ++ +P +P GY V +
Sbjct: 1043 --------SSDKGSPSQSTSVKVMINILDENDNAPRF---SQIFSAHVPENSPLGYTVTR 1091
Query: 1404 L 1404
+
Sbjct: 1092 V 1092
Score = 78.6 bits (185), Expect = 2e-13
Identities = 47/131 (35%), Positives = 72/131 (54%), Gaps = 5/131 (3%)
Query: 765 ISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNAL 824
++ A ++ V I ++D NDNPPVF + + EN G++I + A DADEG NAL
Sbjct: 16 LAAAEVFIVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQ---LTAMDADEGANAL 72
Query: 825 FMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIG 884
YT+ + F +D +G + LDRE++ Y L LV D G SS+ + I +
Sbjct: 73 VTYTIISGADDSFRIDPESGDL-IATRRLDRERRSKYSL-LVRADDGLQSSDMRINITVS 130
Query: 885 DENDNKPEFNQ 895
D ND+ P+F++
Sbjct: 131 DVNDHTPKFSR 141
Score = 74.9 bits (176), Expect = 2e-12
Identities = 101/374 (27%), Positives = 160/374 (42%), Gaps = 43/374 (11%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTD 1090
V + ++D+ND+ PVF + VEE + ++ A DAD G NA +TY I S D
Sbjct: 24 VEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTI-ISGAD 82
Query: 1091 LPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
F I P +G L LDRE KY L V A D DVND++PK
Sbjct: 83 DSFRIDPESGDLIATRRLDRERRSKYSLLVRADDG----LQSSDMRINITVSDVNDHTPK 138
Query: 1151 FYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTD---FI 1207
F + + PE D + ++ AT +++ G V +D D F+
Sbjct: 139 FSR--PVYSFDIPE-DTIPG------SLVAAILATDDDSGVNGEITYIVNEDDEDGIFFL 189
Query: 1208 GNGNGLI-LYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEV-EMSDK-PVFISRYYEL 1264
G+ L L + QQ L + T V + +++D P+F Y
Sbjct: 190 NPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTTIRVYFNILDVNDNPPIFSLNSYST 249
Query: 1265 EIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPD 1322
+ EN+ ++ N+T+ + N ++ Y I + D F +D +NG L ++++ D
Sbjct: 250 SLMENLPVGSTVLVFNVTDADDGINSQLTYSIAS---GDSLGQFTVD-KNGVLKVLKALD 305
Query: 1323 REVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTN 1382
RE + Y ++V+ +LP + P + T +V + + DVNDN P F +
Sbjct: 306 RESQSFYNLVVQV------HDLPQI--PASR-----FTS-TAQVSIILLDVNDNPPTFLS 351
Query: 1383 GNRPLVTAIPTTAP 1396
P +T IP P
Sbjct: 352 ---PKLTYIPENTP 362
Score = 73.3 bits (172), Expect = 6e-12
Identities = 85/333 (25%), Positives = 139/333 (41%), Gaps = 26/333 (7%)
Query: 68 VRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF-IFLIAPIGP 126
+R+ A + + VT+++ D+NDN P F T Y++ ELT G K +F P
Sbjct: 1141 IRVSAHDSGWTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEG 1200
Query: 127 SLTIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSG----NDDGH-FALESSH--K 179
S + + + I A + N + Y V+G N + H F + SS K
Sbjct: 1201 SNGQVFYFIKSQSEYFRINATTGEIFN--KQILKYQNVTGFSNVNINRHSFIVTSSDRGK 1258
Query: 180 PVLLLRKVLD---YDAGDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGATLR 232
P L+ + D+ D Q + + K + + + D+D G+ + +
Sbjct: 1259 PSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVE 1318
Query: 233 YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV 292
Y + + N F LD+ G + + L D N F + V A NP ++QA V
Sbjct: 1319 YFISNDNHLGKFKLDNDTGWISVASSLISDLNQN-----FFITVTAKDKGNPPLSSQATV 1373
Query: 293 EIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD--DPKG 350
I + + N + PEF + +I E+ G V V A D+D NG Y + + +G
Sbjct: 1374 HITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEG 1433
Query: 351 AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
F+I+ +G LT+ LD E M + A
Sbjct: 1434 IFAINSSTGILTLAK--ALDYELCQKHEMTISA 1464
Score = 71.3 bits (167), Expect = 2e-11
Identities = 50/169 (29%), Positives = 83/169 (49%), Gaps = 10/169 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
++A D D G A + Y + +D LF +D G + + LD + + + + L V+
Sbjct: 1514 LNATDADSGTNAVIAYT-VQSSDSDLFVIDPNTGVITTQGFLDFETKQS-----YHLTVK 1567
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A + + + + A V I+L N+ +P F Y I E P G V +V A+D+D G
Sbjct: 1568 AFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGT 1627
Query: 338 NGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAK 384
+GE Y + + K F I+ ++G + V +LDRE + +KV AK
Sbjct: 1628 DGEVHYLIFGNSRKKGFQINKKTGQIYVSG--ILDREKEERVSLKVLAK 1674
Score = 68.5 bits (160), Expect = 2e-10
Identities = 92/405 (22%), Positives = 165/405 (40%), Gaps = 42/405 (10%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPY-HVTVDELTPTGEKAFIFLIAPIGPSLTIP 131
G S+Y + + + DVNDN PIF + P+ ++ L+P + GP+ +
Sbjct: 943 GFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPRKILTVSAMDKDSGPNGQLD 1002
Query: 132 LTVPRG-----LTI------FKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKP 180
+ G +I + +R DR+K + HY + + D +S+
Sbjct: 1003 YEIVNGNMENSFSINHATGEIRSVRPLDREKVS------HYVLTIKSSDKGSPSQSTSVK 1056
Query: 181 VLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND 240
V++ +LD + F + A + D+D+G+ A RY ++ +
Sbjct: 1057 VMI--NILDENDNAPRFSQIFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDAS- 1113
Query: 241 RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLN 300
F+++ G + + + L+ + + + ++V A ++ T V I + D+N
Sbjct: 1114 -LPFTINPSTGDIVISRPLNRE-----DTDRYRIRVSA---HDSGWTVSTDVTIFVTDIN 1164
Query: 301 DNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGW 360
DN P F Y + E G V QV ATD D+G NG+ Y + F I+ +G
Sbjct: 1165 DNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINATTG- 1223
Query: 361 LTVRNQTVLDRE---AHSSLRMKVYAKETNPSVVG-TFADSQRIAKWRRQPLETNAP-LE 415
+ N+ +L + S++ + ++ S G S+ NAP
Sbjct: 1224 -EIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFL 1282
Query: 416 KTTYVFP----DKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNN 456
K+ Y P KVGTK + D++ +N EV +NDN+
Sbjct: 1283 KSKYFTPVTKNVKVGTKLIRVTAIDDKDFG-LNSEVEYFISNDNH 1326
Score = 68.5 bits (160), Expect = 2e-10
Identities = 56/181 (30%), Positives = 88/181 (48%), Gaps = 12/181 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKL-FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D+DLG + Y LI GN RK F ++ G +++ LD + E + VL
Sbjct: 1618 VFASDRDLGTDGEVHY-LIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLK--VLAK 1674
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+ + V + +LD ND P F ++ Y++ I E +P G V V A D D
Sbjct: 1675 NFGSIRGA-DIDEVTVNVTVLDANDP-PIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSI 1732
Query: 337 EN-GEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKET-NPSVVG 392
+ F+Y + + GAFSI+P++G +TV + LDRE + V A ++ PS G
Sbjct: 1733 PSWSRFSYFIGSGNENGAFSINPQTGQITVTAE--LDRETLPIYNLSVLAVDSGTPSATG 1790
Query: 393 T 393
+
Sbjct: 1791 S 1791
Score = 68.1 bits (159), Expect = 2e-10
Identities = 61/168 (36%), Positives = 83/168 (49%), Gaps = 13/168 (7%)
Query: 222 DQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAE--HNLQANTFVL-QVQA 278
D D G+ + L Y + SG+ F++D NG L + K LD +++ +NL L Q+ A
Sbjct: 268 DADDGINSQLTYSIASGDSLGQFTVDK-NGVLKVLKALDRESQSFYNLVVQVHDLPQIPA 326
Query: 279 SQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGEN 338
S+ T+ A+V I LLD+NDN P F + I EN P V + ATD D G N
Sbjct: 327 SRF-----TSTAQVSIILLDVNDNPPTF-LSPKLTYIPENTPIDTVVFKAQATDPDSGPN 380
Query: 339 GEFTYQLDDPKG-AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
Y L +P G FSI G VR LDRE S+ + V A +
Sbjct: 381 SYIEYTLLNPLGNKFSIGTIDG--EVRLTGELDREEVSNYTLTVVATD 426
Score = 66.5 bits (155), Expect = 7e-10
Identities = 40/107 (37%), Positives = 57/107 (53%), Gaps = 4/107 (3%)
Query: 281 LNNPLKTAQAR-VEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
L PL A+ VEI L D+NDN P F D ++++ EN+ +G ++Q+ A D D+G N
Sbjct: 12 LAQPLAAAEVFIVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANA 71
Query: 340 EFTYQ-LDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TY + +F IDP SG L + LDRE S + V A +
Sbjct: 72 LVTYTIISGADDSFRIDPESGDLIATRR--LDRERRSKYSLLVRADD 116
Score = 63.7 bits (148), Expect = 5e-09
Identities = 90/401 (22%), Positives = 159/401 (39%), Gaps = 51/401 (12%)
Query: 992 FVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVND-HFPVFKKTWY 1050
F I+ G ++ A L SE ++ DGG+ S V V+ VN FP +
Sbjct: 811 FHIDPLRGAIMAAGPLNGASEVTFSVHVKDGGSFPKTDSTTVTVRFVNKADFPKVRAKEQ 870
Query: 1051 NFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDR 1110
F E Q ++ + + + ++Y+I + F+I LTG +S++ LD
Sbjct: 871 TFMFPENQPVSSLVTTITGSSL---RGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDF 927
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSN 1170
E KY++ + ARD G DVNDN+P F D + ++ L N
Sbjct: 928 EKIQKYVVWIEARDGG-FPPFSSYEKLDITVLDVNDNAPIFKE-DPFI------SEILEN 979
Query: 1171 HNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLI--LYSLPQRK------ 1222
+ ++ + N + + ++ I + G I + L + K
Sbjct: 980 LSPRKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVL 1039
Query: 1223 --NQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLN 1280
+ G PS S++ +M+ + D E + P F S+ + + E N+P+
Sbjct: 1040 TIKSSDKGSPSQSTSVKVMINILD-----ENDNAPRF-SQIFSAHVPE--NSPLGYTVTR 1091
Query: 1281 LTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKY 1340
+T E+ + I + D F I+P G + + R +RE D Y + V A +
Sbjct: 1092 VTTSDEDIGIN-AISRYSIMDASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGW 1150
Query: 1341 SRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
+ V+ D V + + D+NDN+P+F+
Sbjct: 1151 T---------VSTD-----------VTIFVTDINDNAPRFS 1171
Score = 54.0 bits (124), Expect = 4e-06
Identities = 55/219 (25%), Positives = 99/219 (45%), Gaps = 23/219 (10%)
Query: 913 TAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNS 972
T T+++ F L++ + I E +PIGT + ++A D DS + R+ +
Sbjct: 1688 TVNVTVLDANDPPIFTLNIYSVQ----ISEGVPIGTHVTFVSAFDSDS-IPSWSRFSY-- 1740
Query: 973 EVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDN 1028
+I + F IN + G + V L E+ + L++ A+D G + +
Sbjct: 1741 --FIGSGNENGA-------FSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGS 1791
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNAN-LTYFIQPS 1087
S+ V ++D+ND+ P+ T V E + ++ + +TD D N TY++ +
Sbjct: 1792 ASLLVTLEDINDNGPML--TVSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLST 1849
Query: 1088 DTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+ GVLS E+DRE + L+VV +D+G
Sbjct: 1850 GPATSYFSLSTAGVLSTTREIDREQIADFYLSVVTKDSG 1888
Score = 50.4 bits (115), Expect = 5e-05
Identities = 40/147 (27%), Positives = 71/147 (48%), Gaps = 31/147 (21%)
Query: 1237 ILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYI 1294
I+ +T+ D+ D + PVF + +L +EEN+ +++ L + E N + Y I
Sbjct: 23 IVEITLQDIND-----NPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTI 77
Query: 1295 LNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAED 1354
++ D R IDP +G L R DRE + Y ++VRA+
Sbjct: 78 ISGADDSFR----IDPESGDLIATRRLDRERRSKYSLLVRAD------------------ 115
Query: 1355 VLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
+G+ D+++ + + DVND++PKF+
Sbjct: 116 --DGLQSSDMRINITVSDVNDHTPKFS 140
Score = 50.4 bits (115), Expect = 5e-05
Identities = 44/144 (30%), Positives = 64/144 (44%), Gaps = 11/144 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
++A D D A +R +I GN + F+++ G + LD + + N T V+
Sbjct: 684 VNASDADASKNAVIR--IIGGNSQ--FTINPSTGQIITSALLDRETKDNY---TLVVVCS 736
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVE-NLPNGFSVLQVMATDKDQG 336
+ PL ++ + V + + D+NDN P F+ Y I LP F V V TD D G
Sbjct: 737 DAGSPEPLSSSTS-VLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSF-VFAVTVTDADIG 794
Query: 337 ENGEFTYQLDDPKG-AFSIDPRSG 359
N E Y L F IDP G
Sbjct: 795 PNSELHYSLSGRNSEKFHIDPLRG 818
Score = 45.2 bits (102), Expect = 0.002
Identities = 49/171 (28%), Positives = 79/171 (46%), Gaps = 17/171 (9%)
Query: 36 LAQSIDSLVDSDSPQNVVKFRLGCDFDEGDDLVRIGAGL-NQISAYLSVTVYIEDVNDNV 94
L ++ + +D+ ++ KF+L D D G + + + L + ++ +TV +D N
Sbjct: 1313 LNSEVEYFISNDN--HLGKFKL--DNDTG--WISVASSLISDLNQNFFITVTAKD-KGNP 1365
Query: 95 PIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIFKDIRAFDRDKPNT 154
P+ H+TV E E + S TIP + G +I + + A DRD
Sbjct: 1366 PLSSQATVHITVTE-----ENYHTPEFSQSHMSATIPESHSIG-SIVRTVSARDRDA--A 1417
Query: 155 PNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASG 205
N + YSI SGN++G FA+ SS +L L K LDY+ K + G
Sbjct: 1418 MNGLIKYSISSGNEEGIFAINSS-TGILTLAKALDYELCQKHEMTISAIDG 1467
Score = 40.7 bits (91), Expect = 0.039
Identities = 19/36 (52%), Positives = 23/36 (63%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
+ Y SVTV + DVNDN P+FL Y TV E P+G
Sbjct: 1473 TGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSG 1508
Score = 37.9 bits (84), Expect = 0.28
Identities = 18/43 (41%), Positives = 25/43 (58%)
Query: 1440 QATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
QATD D G N+ I Y +LN +F+I + G VR+ L R+
Sbjct: 371 QATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGELDRE 413
Score = 35.1 bits (77), Expect = 2.0
Identities = 13/38 (34%), Positives = 22/38 (57%)
Query: 1442 TDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAAL 1479
TD+DIG N+++ Y + + +F IDP+ G + L
Sbjct: 789 TDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPL 826
Score = 35.1 bits (77), Expect = 2.0
Identities = 18/47 (38%), Positives = 27/47 (57%), Gaps = 1/47 (2%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
+T +D DIGINA RY I++ P F I+P +G + + L R+
Sbjct: 1089 VTRVTTSDEDIGINAISRYSIMDASLP-FTINPSTGDIVISRPLNRE 1134
Score = 33.1 bits (72), Expect = 7.9
Identities = 17/43 (39%), Positives = 22/43 (51%), Gaps = 1/43 (2%)
Query: 1441 ATDSDIGINADIRYQILNEQA-PRFAIDPVSGTVRVVAALARD 1482
A D D G N +RY I+N F ID V+G + V L R+
Sbjct: 476 AADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDRE 518
>AL031597-2|CAI23555.1| 3014|Homo sapiens cadherin, EGF LAG seven-pass
G-type receptor 1 (flamingo homolog, Drosophila) protein.
Length = 3014
Score = 144 bits (350), Expect = 2e-33
Identities = 190/705 (26%), Positives = 306/705 (43%), Gaps = 98/705 (13%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V +LD NDN P+FV S+ ++ ++ N +G + ++AVD D G+N + Y L T++
Sbjct: 551 VSVQVLDVNDNEPIFV-SSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTAS 609
Query: 505 L--------------TITSPFKINPNTGTVSV-AESPILEGRHALF-VEASDQPANPSER 548
T PF+I+ ++G ++V AE E H F VEA D + P
Sbjct: 610 TFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSS 669
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSY 608
S+++ ++V N D P F YE + + +G+SV ++ D + ++Y
Sbjct: 670 STSVSITVLDV------NDND-PVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITY 722
Query: 609 DLLHGYEEGVPFAVEER--SGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHV 666
L G FA+ + G+IT+ L Y A + S + ++V
Sbjct: 723 QLTGGNTRN-RFALSSQRGGGLITLALPLDYKQEQQYVLAVTA--SDGTRSHTAHVLINV 779
Query: 667 VDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTG-NVRFLIANQQD 725
D N R V + +H + ++ G +I + S TG N R Q
Sbjct: 780 TDANTHRPVF-QSSHYTVSVS-EDRPVGTSIATL------SANDEDTGENARITYVIQDP 831
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP 785
V + GT++T LD E + Y +T++A+ N G+ + + I I D NDN P
Sbjct: 832 VPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDN-GIPQKSDTTTLEILILDANDNAP 890
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG--EGKEMFDVDENT 843
F Y+G I E++ T I + ATD D G N +YT G +G F ++ +
Sbjct: 891 QFLWDFYQGSIFEDAPPSTSILQ---VSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTS 947
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTGG---LSSEAELIIMIGDENDNKPEFNQIEENS 900
GV++ LDRE +Y L +A D G LS+ E+ + I D NDN P F E
Sbjct: 948 GVIR-TQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF----EKD 1002
Query: 901 KVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDS 960
++ + E N G + +++ A D D+ GP I I G + LDL
Sbjct: 1003 ELELFVEE--NNPVGSVVAKIR-----ANDPDE-GPNAQIMYQIVEG-DMRHFFQLDL-- 1051
Query: 961 GLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISAL 1020
LNG +R + + D EV+R +V+ V+ A S P S ++I +
Sbjct: 1052 -LNGDLR-----------AMVELD-FEVRREYVL------VVQATSAPLVSRATVHILLV 1092
Query: 1021 DGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA-QYTRRVLGKVDATDADFGQNAN 1079
D NDN V P F+ + N+ ++ + V+G + A D D + N
Sbjct: 1093 D---QNDNPPV----------LPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLN 1139
Query: 1080 LTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARD 1124
T F+Q ++ L + P TG L ++ +LD + ++ V D
Sbjct: 1140 YT-FVQGNELRL-LLLDPATGELQLSRDLDNNRPLEALMEVSVSD 1182
Score = 127 bits (306), Expect = 3e-28
Identities = 130/471 (27%), Positives = 212/471 (45%), Gaps = 38/471 (8%)
Query: 430 ENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDL 489
E +++ + S +V +T+LD NDN+PVF YE + +A VG+ + ++A D D
Sbjct: 658 EAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPT-YELRLNEDAAVGSSVLTLQARDRDA 716
Query: 490 GQNGMVLYDLQRTSNLTITSPFKINPNTG----TVSVAESPILEGRHALFVEASDQPANP 545
N ++ Y L T T + F ++ G T+++ E ++ L V ASD
Sbjct: 717 --NSVITYQL--TGGNT-RNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT--- 768
Query: 546 SERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND 605
R A V I VT P F + Y V + +GTS+ + ND E
Sbjct: 769 ---RSHTAHVLINVTDANTHR----PVFQSSHYTVSVSEDRPVGTSIATLSAND--EDTG 819
Query: 606 VSYDLLHGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA--NLSIVTNA 662
+ + + ++ VP F ++ SG + + +L N+ Y +A Q+N S T
Sbjct: 820 ENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMA-QDNGIPQKSDTTTL 878
Query: 663 TVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIAN 722
+ ++D ND L + IF ++ +I Q+ T+ S G + +
Sbjct: 879 EILILDANDNAPQFLWDFYQGSIF--EDAPPSTSILQVSATDRDS---GPNGRLLYTFQG 933
Query: 723 QQDVTDDIAIAE-DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
D D I G I TQ+ LDRE VY + +A + ++ + I D N
Sbjct: 934 GDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDIN 993
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVD 840
DN P+FE E F+ EN+ +G+ + I+A D DEG NA MY + G+ + F +D
Sbjct: 994 DNAPMFEKDELELFVEENNPVGSVVAK---IRANDPDEGPNAQIMYQIVEGDMRHFFQLD 1050
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKP 891
G ++ + + LD E + Y L +V + L S A + I++ D+NDN P
Sbjct: 1051 LLNGDLRAMVE-LDFEVRREYVL-VVQATSAPLVSRATVHILLVDQNDNPP 1099
Score = 99.5 bits (237), Expect = 8e-20
Identities = 122/489 (24%), Positives = 216/489 (44%), Gaps = 44/489 (8%)
Query: 428 KTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDP 487
+ + ++Y + + V + D ND++PVF S Y ++ N +VG + ++A D
Sbjct: 322 RVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSE-YRERVRENLEVGYEVLTIRASDR 380
Query: 488 DLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANP 545
D N + Y + + F++N ++G VS E + L VEA+DQ NP
Sbjct: 381 DSPINANLRYRVLGGA----WDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNP 436
Query: 546 SERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE-QN 604
+ A V IEV + + P F Y V +VG+ T+V +++ D + QN
Sbjct: 437 GPLS-ATATVYIEV----EDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQN 491
Query: 605 -DVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNA- 662
+ Y +L G G F + SG++ V++ L + Y ++ Q+ ++ ++
Sbjct: 492 AAIHYSILSGNVAG-QFYLHSLSGILDVINPLDFEDVQKYSL-SIKAQDGGRPPLINSSG 549
Query: 663 --TVHVVDVNDERGVLLKG-------AHSPI---IFHVKENSAGAAIGQIFHTNM----S 706
+V V+DVND + + + P+ + H++ A + H + S
Sbjct: 550 VVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTAS 609
Query: 707 SIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVIS 766
+ G G+ + A D I G I LDRE+ + Y V A + G
Sbjct: 610 TFLGGGSAGPK-NPAPTPDFPFQIH-NSSGWITVCAELDREEVEHYSFGVEA-VDHGSPP 666
Query: 767 GAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFM 826
+ V+I + D NDN PVF TYE + E++ +G+ + ++A D D N++
Sbjct: 667 MSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVL---TLQARDRD--ANSVIT 721
Query: 827 YTLF-GEGKEMFDV-DENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIG 884
Y L G + F + + G + + LD +++ Y L++ A D G S A ++I +
Sbjct: 722 YQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD-GTRSHTAHVLINVT 780
Query: 885 DENDNKPEF 893
D N ++P F
Sbjct: 781 DANTHRPVF 789
Score = 98.3 bits (234), Expect = 2e-19
Identities = 116/437 (26%), Positives = 192/437 (43%), Gaps = 68/437 (15%)
Query: 929 LDVDQLGPLFLIP-------ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LDV+ P+F P E+ +G++++ L A D D+ N I Y+
Sbjct: 678 LDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA--NSVITYQLTGG-------- 727
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLNISALDGGNLNDNISVRVFVKD 1037
+ F ++ + G ++ +LP E ++ L ++A DG + V + V D
Sbjct: 728 -----NTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR-SHTAHVLINVTD 781
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISP 1097
N H PVF+ + Y +V E + + + A D D G+NA +TY IQ D F I P
Sbjct: 782 ANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ--DPVPQFRIDP 839
Query: 1098 LTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDEL 1157
+G + ELD E + Y LT++A+DNG D NDN+P+F
Sbjct: 840 DSGTMYTMMELDYENQVAYTLTIMAQDNG-IPQKSDTTTLEILILDANDNAPQFL----- 893
Query: 1158 LEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDT---DF-IGNGNGL 1213
W + + S ++ V AT ++ P G + D DF I +G+
Sbjct: 894 --WDFYQGSIFEDAP-PSTSILQV-SATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGV 949
Query: 1214 ILYSLPQRKNQQNL------------GLPS-LSSTAILMVTVADVPDEVEMSDKPVFISR 1260
I +R +++N+ G P+ LS++ + VT+ D+ D + P+F
Sbjct: 950 I--RTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDIND-----NAPMFEKD 1002
Query: 1261 YYELEIEEN--VNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLV 1318
EL +EEN V + V + N + N ++ Y I+ + D+R F +D NG L +
Sbjct: 1003 ELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV---EGDMRHFFQLDLLNGDLRAM 1059
Query: 1319 RSPDREVKDTYEVIVRA 1335
D EV+ Y ++V+A
Sbjct: 1060 VELDFEVRREYVLVVQA 1076
Score = 95.5 bits (227), Expect = 1e-18
Identities = 91/314 (28%), Positives = 136/314 (43%), Gaps = 31/314 (9%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPL 132
G +S+ SV++ + DVNDN P+F Y + ++E G + I
Sbjct: 663 GSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITY 722
Query: 133 TVPRGLTIFKDIRAFDRDK-------PNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR 185
+ G T + + R P + Y + DG SH +L+
Sbjct: 723 QLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG----TRSHTAHVLIN 778
Query: 186 KVLDYDAGDKEFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDR 241
V D + FQ V ++ + + I + A D+D G A + Y + +
Sbjct: 779 -VTDANTHRPVFQSSHYTVSVSEDRPVGTSIA---TLSANDEDTGENARITY--VIQDPV 832
Query: 242 KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLND 301
F +D +G+++ ELD + N A T + Q + + P K+ +EI +LD ND
Sbjct: 833 PQFRIDPDSGTMYTMMELDYE---NQVAYTLTIMAQDNGI--PQKSDTTTLEILILDAND 887
Query: 302 NLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL---DDPKGAFSIDPRS 358
N P+F DFY SI E+ P S+LQV ATD+D G NG Y DD G F I+P S
Sbjct: 888 NAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTS 947
Query: 359 GWLTVRNQTVLDRE 372
G +R Q LDRE
Sbjct: 948 G--VIRTQRRLDRE 959
Score = 93.5 bits (222), Expect = 5e-18
Identities = 61/180 (33%), Positives = 98/180 (54%), Gaps = 11/180 (6%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G + T LDRE ++ + + V A A Y +T+ ++D ND+ PVFE + Y
Sbjct: 303 GAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTY-ITVLVKDTNDHSPVFEQSEYRER 361
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
+ EN ++G E+ I+A+D D NA Y + G ++F ++E++GVV LDR
Sbjct: 362 VRENLEVGYEVL---TIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVS-TRAVLDR 417
Query: 856 EKKIMYKLSLVA----RDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
E+ Y+L + A R+ G LS+ A + I + DENDN P+F+ E+N V++ + LN
Sbjct: 418 EEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFS--EQNYVVQVPEDVGLN 475
Score = 91.9 bits (218), Expect = 2e-17
Identities = 121/449 (26%), Positives = 187/449 (41%), Gaps = 61/449 (13%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
IEV+ +N + + +PE++ + T ++++ A D D G N I Y
Sbjct: 447 IEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHY---------- 496
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN---LNDNISVRV 1033
S LS + V F ++ G + V L E ++ L+I A DGG +N + V V
Sbjct: 497 SILSGN---VAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSV 553
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI--------- 1084
V DVND+ P+F + + V E + + A DAD G+NA L Y +
Sbjct: 554 QVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLG 613
Query: 1085 -------QPSDT-DLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXX 1136
P+ T D PF+I +G ++V ELDRE + Y V A D+G
Sbjct: 614 GGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHG-SPPMSSSTS 672
Query: 1137 XXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTV 1196
DVNDN P F E + E + + + I G T
Sbjct: 673 VSITVLDVNDNDPVF--TQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTR 730
Query: 1197 AKVFANDTDFIGNGNGLILYSLP-QRKNQQNLGLP------SLSSTAILMVTVADVPDEV 1249
+ FA + G GLI +LP K +Q L + S TA +++ V D
Sbjct: 731 NR-FALSSQ---RGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDA---- 782
Query: 1250 EMSDKPVFISRYYELEIEEN--VNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFV 1307
+ +PVF S +Y + + E+ V + +S N + EN ++ Y I D F
Sbjct: 783 -NTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVI-----QDPVPQFR 836
Query: 1308 IDPRNGTLYLVRSPDREVKDTYEVIVRAE 1336
IDP +GT+Y + D E + Y + + A+
Sbjct: 837 IDPDSGTMYTMMELDYENQVAYTLTIMAQ 865
Score = 91.5 bits (217), Expect = 2e-17
Identities = 100/348 (28%), Positives = 152/348 (43%), Gaps = 58/348 (16%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ E+ P+GT+I L+A D D+G N +I Y V P ++ D+ G
Sbjct: 798 VSEDRPVGTSIATLSANDEDTGENARITYVIQDPV--PQFRIDPDS-------------G 842
Query: 1000 HVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNV- 1054
+ L E++ + L I A D G +D ++ + + D ND+ P F +Y ++
Sbjct: 843 TMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIF 902
Query: 1055 EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT-DLPFEISPLTGVLSVNGELDRETE 1113
E+A + +L +V ATD D G N L Y Q D D F I P +GV+ LDRE
Sbjct: 903 EDAPPSTSIL-QVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENV 961
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNF 1173
Y L +A D G D+NDN+P F E DEL
Sbjct: 962 AVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF------------EKDEL----- 1004
Query: 1174 ESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLS 1233
+ +EEN P+G+ VAK+ AND D N I+Y + + + L L+
Sbjct: 1005 ---------ELFVEENNPVGSVVAKIRANDPD--EGPNAQIMYQIVEGDMRHFFQLDLLN 1053
Query: 1234 STAILMVTV-ADVPDE----VEMSDKPVFISR--YYELEIEENVNAPV 1274
MV + +V E V+ + P+ +SR + L +++N N PV
Sbjct: 1054 GDLRAMVELDFEVRREYVLVVQATSAPL-VSRATVHILLVDQNDNPPV 1100
Score = 86.6 bits (205), Expect = 6e-16
Identities = 67/218 (30%), Positives = 100/218 (45%), Gaps = 20/218 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN+ +G ++ + A D DS +N +RY ++ A +V F +NE G
Sbjct: 362 VRENLEVGYEVLTIRASDRDSPINANLRY-----------RVLGGAWDV---FQLNESSG 407
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGN----LNDNISVRVFVKDVNDHFPVFKKTWYNFN 1053
V L E +E++L + A D G L+ +V + V+D ND++P F + Y
Sbjct: 408 VVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQ 467
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETE 1113
V E + +V ATD D GQNA + Y I + F + L+G+L V LD E
Sbjct: 468 VPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDV 527
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
KY L++ A+D G DVNDN P F
Sbjct: 528 QKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIF 565
Score = 83.8 bits (198), Expect = 4e-15
Identities = 53/163 (32%), Positives = 80/163 (49%), Gaps = 8/163 (4%)
Query: 223 QDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLN 282
+D + + Y+L GN R F+L S G + L LD + Q +VL V AS
Sbjct: 712 RDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQ---YVLAVTAS--- 765
Query: 283 NPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFT 342
+ ++ A V I + D N + P F+ Y +S+ E+ P G S+ + A D+D GEN T
Sbjct: 766 DGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARIT 825
Query: 343 YQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
Y + DP F IDP SG T+ LD E + + + A++
Sbjct: 826 YVIQDPVPQFRIDPDSG--TMYTMMELDYENQVAYTLTIMAQD 866
Score = 79.8 bits (188), Expect = 7e-14
Identities = 110/462 (23%), Positives = 186/462 (40%), Gaps = 45/462 (9%)
Query: 461 PSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTV 520
P Y+ ++ N GT+I ++ A G+ V Y ++ + F+I+ TG V
Sbjct: 246 PMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAV 305
Query: 521 SVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPY 578
S E + H L V+A D P R + +T+ V K P F + Y
Sbjct: 306 STDSVLDRETKETHVLRVKAVDYSTPP---RSATTYITVLV----KDTNDHSPVFEQSEY 358
Query: 579 EFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLS 636
V N+ +G V IR +D ++ Y +L G + F + E SGV++ L
Sbjct: 359 RERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWD--VFQLNESSGVVSTRAVLD 416
Query: 637 RYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKEN-SAGA 695
R Y A + N ++ ++V DE + + + V E+
Sbjct: 417 REEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNT 476
Query: 696 AIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMT 755
A+ ++ T+ G + + I + + G + PLD E Y ++
Sbjct: 477 AVLRVQATDRDQ--GQNAA-IHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLS 533
Query: 756 VIAEFN--KGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIK 813
+ A+ +I+ +G+ V++ + D NDN P+F + ++ ++EN +G + I+
Sbjct: 534 IKAQDGGRPPLINSSGV--VSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVH---IQ 588
Query: 814 ATDADEGTNALFMY-------TLFGEGKE-----------MFDVDENTGVVKFIGDSLDR 855
A DAD G NA Y T G G F + ++G + + LDR
Sbjct: 589 AVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAE-LDR 647
Query: 856 EKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
E+ Y + A D G +SS + I + D NDN P F Q
Sbjct: 648 EEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQ 689
Score = 79.0 bits (186), Expect = 1e-13
Identities = 114/457 (24%), Positives = 187/457 (40%), Gaps = 41/457 (8%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
EN P GT I++L+A G ++ Y + ++ S+ YF I+ G V
Sbjct: 256 ENEPAGTLILQLHAHYTIEGEEERVSY-YMEGLFDERSR---------GYFRIDSATGAV 305
Query: 1002 IVARSLPPESEFR--LNISALDGGNLNDNIS--VRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
L E++ L + A+D + + + V VKD NDH PVF+++ Y V E
Sbjct: 306 STDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVREN 365
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYI 1117
+ + A+D D NANL Y + D+ F+++ +GV+S LDRE +Y
Sbjct: 366 LEVGYEVLTIRASDRDSPINANLRYRVLGGAWDV-FQLNESSGVVSTRAVLDREEAAEYQ 424
Query: 1118 LTVVARDNGXX-XXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESV 1176
L V A D G D NDN P+F + +++ + ++
Sbjct: 425 LLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQAT 484
Query: 1177 MMIPVYKATIEENAPIGTTVAKVFAND----TDFIG--NGNGLILYSLPQRKNQQNLGLP 1230
A I + G + + + D I + + YSL K Q P
Sbjct: 485 DRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSL-SIKAQDGGRPP 543
Query: 1231 SLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEHYENF 1288
++S+ ++ V V DV D ++P+F+S ++ + ENV PV + + EN
Sbjct: 544 LINSSGVVSVQVLDVND-----NEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENA 598
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVK---DTYEVIVRAERQKYSRELP 1345
++ Y ++ D TF+ G +PD + + + V AE + E+
Sbjct: 599 RLHYRLV-----DTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDR--EEVE 651
Query: 1346 HMIYPV-AEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
H + V A D V + + DVNDN P FT
Sbjct: 652 HYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFT 688
Score = 78.2 bits (184), Expect = 2e-13
Identities = 43/135 (31%), Positives = 71/135 (52%), Gaps = 4/135 (2%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D+D G A + Y ++SGN F L S++G L + LD + ++Q + ++ Q
Sbjct: 481 VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFE---DVQKYSLSIKAQ 537
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
PL + V +++LD+NDN P F + +++EN+P G+ V+ + A D D GE
Sbjct: 538 DGG-RPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGE 596
Query: 338 NGEFTYQLDDPKGAF 352
N Y+L D F
Sbjct: 597 NARLHYRLVDTASTF 611
Score = 70.9 bits (166), Expect = 3e-11
Identities = 83/350 (23%), Positives = 148/350 (42%), Gaps = 30/350 (8%)
Query: 444 NVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTS 503
+V + + DAN + PVF S+ Y S+ + VGT I + A D D G+N + Y +Q
Sbjct: 774 HVLINVTDANTHRPVFQSSH-YTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDP- 831
Query: 504 NLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTR 561
F+I+P++GT+ E + + L + A D +L ++ ++
Sbjct: 832 ----VPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDAN- 886
Query: 562 GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLHGYEEGVP 619
+ P F+ Y+ + + TS+ Q+ D + + Y G +
Sbjct: 887 ------DNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGD 940
Query: 620 FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN--LSIVTNATVHVVDVNDERGVLL 677
F +E SGVI L R N +Y+ A+A+ + LS V ++D+ND +
Sbjct: 941 FYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFE 1000
Query: 678 KGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDG 736
K +F + N G+ + +I + + + I + D+ + +G
Sbjct: 1001 KDELE--LFVEENNPVGSVVAKIRANDPDE---GPNAQIMYQIV-EGDMRHFFQLDLLNG 1054
Query: 737 TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
+ LD E R Y + V A + ++S A ++ I + D+NDNPPV
Sbjct: 1055 DLRAMVELDFEVRREYVLVVQAT-SAPLVSRATVH---ILLVDQNDNPPV 1100
Score = 70.1 bits (164), Expect = 6e-11
Identities = 60/205 (29%), Positives = 98/205 (47%), Gaps = 11/205 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I A D+D + A LRY ++ G +F L+ +G + LD + +A + L V+
Sbjct: 375 IRASDRDSPINANLRYRVLGGA-WDVFQLNESSGVVSTRAVLDRE-----EAAEYQLLVE 428
Query: 278 AS-QLNNPLK-TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
A+ Q NP +A A V IE+ D NDN P+F Y + + E++ +VL+V ATD+DQ
Sbjct: 429 ANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQ 488
Query: 336 GENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
G+N Y + + G F + SG L V N + SL +K P + +
Sbjct: 489 GQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSS 548
Query: 394 FADSQRIAKWR-RQPLETNAPLEKT 417
S ++ +P+ ++P + T
Sbjct: 549 GVVSVQVLDVNDNEPIFVSSPFQAT 573
Score = 67.3 bits (157), Expect = 4e-10
Identities = 45/152 (29%), Positives = 73/152 (48%), Gaps = 8/152 (5%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
L R F +DS G++ + LD + + T VL+V+A + P ++A + +
Sbjct: 287 LFDERSRGYFRIDSATGAVSTDSVLDRETKE-----THVLRVKAVDYSTPPRSATTYITV 341
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ-LDDPKGAFS 353
+ D ND+ P FE Y + ENL G+ VL + A+D+D N Y+ L F
Sbjct: 342 LVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQ 401
Query: 354 IDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
++ SG V + VLDRE + ++ V A +
Sbjct: 402 LNESSG--VVSTRAVLDREEAAEYQLLVEAND 431
Score = 66.5 bits (155), Expect = 7e-10
Identities = 50/169 (29%), Positives = 79/169 (46%), Gaps = 9/169 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKL-FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D+D G L Y G+D F ++ +G + ++ LD E+ N + L V
Sbjct: 914 VSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLD--RENVAVYNLWALAV 971
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
PL +A +++ +LD+NDN P FE D + + EN P G V ++ A D D+G
Sbjct: 972 DRGS-PTPL-SASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEG 1029
Query: 337 ENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
N + YQ+ D + F +D +G +R LD E + V A
Sbjct: 1030 PNAQIMYQIVEGDMRHFFQLDLLNG--DLRAMVELDFEVRREYVLVVQA 1076
Score = 64.9 bits (151), Expect = 2e-09
Identities = 61/237 (25%), Positives = 107/237 (45%), Gaps = 17/237 (7%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L + V ++VT+LD NDN P+F L E ++ N VG+V+ K++A DPD G N ++Y
Sbjct: 979 LSASVEIQVTILDINDNAPMFEKDEL-ELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQ 1037
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVT 556
+ + F+++ G + E R + L V+A+ P S A V
Sbjct: 1038 IVEGD---MRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPL------VSRATVH 1088
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSV-GQIRVNDAFEQNDVSYDLLHGYE 615
I + N P +PDF + + T V G I +D + ++Y + G E
Sbjct: 1089 ILLV-DQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNE 1147
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDE 672
+ ++ +G + + DL NRP+ V++ + + S+ T+ V + D+
Sbjct: 1148 LRL-LLLDPATGELQLSRDLDN-NRPLEALMEVSVSDGIH-SVTAFCTLRVTIITDD 1201
Score = 61.7 bits (143), Expect = 2e-08
Identities = 52/170 (30%), Positives = 81/170 (47%), Gaps = 16/170 (9%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I A D D G A + Y+++ G+ R F LD +NG L ELD + +VL VQ
Sbjct: 1021 IRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRRE-----YVLVVQ 1075
Query: 278 ASQLNNPLKTAQARVEIELLDLNDN---LPEFEVDFYNISIVENLPNGFS---VLQVMAT 331
A+ PL ++A V I L+D NDN LP+F++ F N V N N F + + A
Sbjct: 1076 ATSA--PL-VSRATVHILLVDQNDNPPVLPDFQILFNN--YVTNKSNSFPTGVIGCIPAH 1130
Query: 332 DKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKV 381
D D ++ +T+ + +DP +G L + +R + + + V
Sbjct: 1131 DPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSV 1180
Score = 47.2 bits (107), Expect = 5e-04
Identities = 81/343 (23%), Positives = 130/343 (37%), Gaps = 37/343 (10%)
Query: 71 GAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPI----GP 126
G +SA +V + +ED NDN P F + Y V V E G + + G
Sbjct: 433 GRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPE--DVGLNTAVLRVQATDRDQGQ 490
Query: 127 SLTIPLTVPRG-----LTIFKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKP 180
+ I ++ G + D P YS+ + D G L +S
Sbjct: 491 NAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGV 550
Query: 181 VLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEP-IHAIDQDLGVGATLRYELISGN 239
V + +VLD + + F + + + +P I A+D D G A L Y L+
Sbjct: 551 VSV--QVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTA 608
Query: 240 DRKL---------------FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNP 284
L F N S ++ +LD E + + V+A +P
Sbjct: 609 STFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDRE---EVEHYSFGVEAVDHGSP 665
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
++ V I +LD+NDN P F Y + + E+ G SVL + A D+D N TYQ
Sbjct: 666 PMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQ 723
Query: 345 L--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
L + + F++ + G + LD + + V A +
Sbjct: 724 LTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD 766
Score = 39.1 bits (87), Expect = 0.12
Identities = 29/97 (29%), Positives = 46/97 (47%), Gaps = 9/97 (9%)
Query: 305 EFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD-----PKGAFSIDPRSG 359
+F + Y +++ EN P G +LQ+ A +GE +Y ++ +G F ID +G
Sbjct: 244 KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
Query: 360 WLTVRNQTVLDREAHSS--LRMKVYAKETNPSVVGTF 394
V +VLDRE + LR+K T P T+
Sbjct: 304 --AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTY 338
Score = 34.3 bits (75), Expect = 3.4
Identities = 17/39 (43%), Positives = 23/39 (58%), Gaps = 1/39 (2%)
Query: 1441 ATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAAL 1479
A D D G NA I Y ++ + P+F IDP SGT+ + L
Sbjct: 813 ANDEDTGENARITY-VIQDPVPQFRIDPDSGTMYTMMEL 850
>AL031588-3|CAI19319.1| 3014|Homo sapiens cadherin, EGF LAG seven-pass
G-type receptor 1 (flamingo homolog, Drosophila) protein.
Length = 3014
Score = 144 bits (350), Expect = 2e-33
Identities = 190/705 (26%), Positives = 306/705 (43%), Gaps = 98/705 (13%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V +LD NDN P+FV S+ ++ ++ N +G + ++AVD D G+N + Y L T++
Sbjct: 551 VSVQVLDVNDNEPIFV-SSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTAS 609
Query: 505 L--------------TITSPFKINPNTGTVSV-AESPILEGRHALF-VEASDQPANPSER 548
T PF+I+ ++G ++V AE E H F VEA D + P
Sbjct: 610 TFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSS 669
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSY 608
S+++ ++V N D P F YE + + +G+SV ++ D + ++Y
Sbjct: 670 STSVSITVLDV------NDND-PVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITY 722
Query: 609 DLLHGYEEGVPFAVEER--SGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHV 666
L G FA+ + G+IT+ L Y A + S + ++V
Sbjct: 723 QLTGGNTRN-RFALSSQRGGGLITLALPLDYKQEQQYVLAVTA--SDGTRSHTAHVLINV 779
Query: 667 VDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTG-NVRFLIANQQD 725
D N R V + +H + ++ G +I + S TG N R Q
Sbjct: 780 TDANTHRPVF-QSSHYTVSVS-EDRPVGTSIATL------SANDEDTGENARITYVIQDP 831
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP 785
V + GT++T LD E + Y +T++A+ N G+ + + I I D NDN P
Sbjct: 832 VPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDN-GIPQKSDTTTLEILILDANDNAP 890
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG--EGKEMFDVDENT 843
F Y+G I E++ T I + ATD D G N +YT G +G F ++ +
Sbjct: 891 QFLWDFYQGSIFEDAPPSTSILQ---VSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTS 947
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTGG---LSSEAELIIMIGDENDNKPEFNQIEENS 900
GV++ LDRE +Y L +A D G LS+ E+ + I D NDN P F E
Sbjct: 948 GVIR-TQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF----EKD 1002
Query: 901 KVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDS 960
++ + E N G + +++ A D D+ GP I I G + LDL
Sbjct: 1003 ELELFVEE--NNPVGSVVAKIR-----ANDPDE-GPNAQIMYQIVEG-DMRHFFQLDL-- 1051
Query: 961 GLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISAL 1020
LNG +R + + D EV+R +V+ V+ A S P S ++I +
Sbjct: 1052 -LNGDLR-----------AMVELD-FEVRREYVL------VVQATSAPLVSRATVHILLV 1092
Query: 1021 DGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA-QYTRRVLGKVDATDADFGQNAN 1079
D NDN V P F+ + N+ ++ + V+G + A D D + N
Sbjct: 1093 D---QNDNPPV----------LPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLN 1139
Query: 1080 LTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARD 1124
T F+Q ++ L + P TG L ++ +LD + ++ V D
Sbjct: 1140 YT-FVQGNELRL-LLLDPATGELQLSRDLDNNRPLEALMEVSVSD 1182
Score = 127 bits (306), Expect = 3e-28
Identities = 130/471 (27%), Positives = 212/471 (45%), Gaps = 38/471 (8%)
Query: 430 ENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDL 489
E +++ + S +V +T+LD NDN+PVF YE + +A VG+ + ++A D D
Sbjct: 658 EAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPT-YELRLNEDAAVGSSVLTLQARDRDA 716
Query: 490 GQNGMVLYDLQRTSNLTITSPFKINPNTG----TVSVAESPILEGRHALFVEASDQPANP 545
N ++ Y L T T + F ++ G T+++ E ++ L V ASD
Sbjct: 717 --NSVITYQL--TGGNT-RNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT--- 768
Query: 546 SERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND 605
R A V I VT P F + Y V + +GTS+ + ND E
Sbjct: 769 ---RSHTAHVLINVTDANTHR----PVFQSSHYTVSVSEDRPVGTSIATLSAND--EDTG 819
Query: 606 VSYDLLHGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA--NLSIVTNA 662
+ + + ++ VP F ++ SG + + +L N+ Y +A Q+N S T
Sbjct: 820 ENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMA-QDNGIPQKSDTTTL 878
Query: 663 TVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIAN 722
+ ++D ND L + IF ++ +I Q+ T+ S G + +
Sbjct: 879 EILILDANDNAPQFLWDFYQGSIF--EDAPPSTSILQVSATDRDS---GPNGRLLYTFQG 933
Query: 723 QQDVTDDIAIAE-DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
D D I G I TQ+ LDRE VY + +A + ++ + I D N
Sbjct: 934 GDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDIN 993
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVD 840
DN P+FE E F+ EN+ +G+ + I+A D DEG NA MY + G+ + F +D
Sbjct: 994 DNAPMFEKDELELFVEENNPVGSVVAK---IRANDPDEGPNAQIMYQIVEGDMRHFFQLD 1050
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKP 891
G ++ + + LD E + Y L +V + L S A + I++ D+NDN P
Sbjct: 1051 LLNGDLRAMVE-LDFEVRREYVL-VVQATSAPLVSRATVHILLVDQNDNPP 1099
Score = 99.5 bits (237), Expect = 8e-20
Identities = 122/489 (24%), Positives = 216/489 (44%), Gaps = 44/489 (8%)
Query: 428 KTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDP 487
+ + ++Y + + V + D ND++PVF S Y ++ N +VG + ++A D
Sbjct: 322 RVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSE-YRERVRENLEVGYEVLTIRASDR 380
Query: 488 DLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANP 545
D N + Y + + F++N ++G VS E + L VEA+DQ NP
Sbjct: 381 DSPINANLRYRVLGGA----WDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNP 436
Query: 546 SERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE-QN 604
+ A V IEV + + P F Y V +VG+ T+V +++ D + QN
Sbjct: 437 GPLS-ATATVYIEV----EDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQN 491
Query: 605 -DVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNA- 662
+ Y +L G G F + SG++ V++ L + Y ++ Q+ ++ ++
Sbjct: 492 AAIHYSILSGNVAG-QFYLHSLSGILDVINPLDFEDVQKYSL-SIKAQDGGRPPLINSSG 549
Query: 663 --TVHVVDVNDERGVLLKG-------AHSPI---IFHVKENSAGAAIGQIFHTNM----S 706
+V V+DVND + + + P+ + H++ A + H + S
Sbjct: 550 VVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTAS 609
Query: 707 SIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVIS 766
+ G G+ + A D I G I LDRE+ + Y V A + G
Sbjct: 610 TFLGGGSAGPK-NPAPTPDFPFQIH-NSSGWITVCAELDREEVEHYSFGVEA-VDHGSPP 666
Query: 767 GAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFM 826
+ V+I + D NDN PVF TYE + E++ +G+ + ++A D D N++
Sbjct: 667 MSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVL---TLQARDRD--ANSVIT 721
Query: 827 YTLF-GEGKEMFDV-DENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIG 884
Y L G + F + + G + + LD +++ Y L++ A D G S A ++I +
Sbjct: 722 YQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD-GTRSHTAHVLINVT 780
Query: 885 DENDNKPEF 893
D N ++P F
Sbjct: 781 DANTHRPVF 789
Score = 98.3 bits (234), Expect = 2e-19
Identities = 116/437 (26%), Positives = 192/437 (43%), Gaps = 68/437 (15%)
Query: 929 LDVDQLGPLFLIP-------ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LDV+ P+F P E+ +G++++ L A D D+ N I Y+
Sbjct: 678 LDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA--NSVITYQLTGG-------- 727
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLNISALDGGNLNDNISVRVFVKD 1037
+ F ++ + G ++ +LP E ++ L ++A DG + V + V D
Sbjct: 728 -----NTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR-SHTAHVLINVTD 781
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISP 1097
N H PVF+ + Y +V E + + + A D D G+NA +TY IQ D F I P
Sbjct: 782 ANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ--DPVPQFRIDP 839
Query: 1098 LTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDEL 1157
+G + ELD E + Y LT++A+DNG D NDN+P+F
Sbjct: 840 DSGTMYTMMELDYENQVAYTLTIMAQDNG-IPQKSDTTTLEILILDANDNAPQFL----- 893
Query: 1158 LEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDT---DF-IGNGNGL 1213
W + + S ++ V AT ++ P G + D DF I +G+
Sbjct: 894 --WDFYQGSIFEDAP-PSTSILQV-SATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGV 949
Query: 1214 ILYSLPQRKNQQNL------------GLPS-LSSTAILMVTVADVPDEVEMSDKPVFISR 1260
I +R +++N+ G P+ LS++ + VT+ D+ D + P+F
Sbjct: 950 I--RTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDIND-----NAPMFEKD 1002
Query: 1261 YYELEIEEN--VNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLV 1318
EL +EEN V + V + N + N ++ Y I+ + D+R F +D NG L +
Sbjct: 1003 ELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV---EGDMRHFFQLDLLNGDLRAM 1059
Query: 1319 RSPDREVKDTYEVIVRA 1335
D EV+ Y ++V+A
Sbjct: 1060 VELDFEVRREYVLVVQA 1076
Score = 95.5 bits (227), Expect = 1e-18
Identities = 91/314 (28%), Positives = 136/314 (43%), Gaps = 31/314 (9%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPL 132
G +S+ SV++ + DVNDN P+F Y + ++E G + I
Sbjct: 663 GSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITY 722
Query: 133 TVPRGLTIFKDIRAFDRDK-------PNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR 185
+ G T + + R P + Y + DG SH +L+
Sbjct: 723 QLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG----TRSHTAHVLIN 778
Query: 186 KVLDYDAGDKEFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDR 241
V D + FQ V ++ + + I + A D+D G A + Y + +
Sbjct: 779 -VTDANTHRPVFQSSHYTVSVSEDRPVGTSIA---TLSANDEDTGENARITY--VIQDPV 832
Query: 242 KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLND 301
F +D +G+++ ELD + N A T + Q + + P K+ +EI +LD ND
Sbjct: 833 PQFRIDPDSGTMYTMMELDYE---NQVAYTLTIMAQDNGI--PQKSDTTTLEILILDAND 887
Query: 302 NLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL---DDPKGAFSIDPRS 358
N P+F DFY SI E+ P S+LQV ATD+D G NG Y DD G F I+P S
Sbjct: 888 NAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTS 947
Query: 359 GWLTVRNQTVLDRE 372
G +R Q LDRE
Sbjct: 948 G--VIRTQRRLDRE 959
Score = 93.5 bits (222), Expect = 5e-18
Identities = 61/180 (33%), Positives = 98/180 (54%), Gaps = 11/180 (6%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G + T LDRE ++ + + V A A Y +T+ ++D ND+ PVFE + Y
Sbjct: 303 GAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTY-ITVLVKDTNDHSPVFEQSEYRER 361
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
+ EN ++G E+ I+A+D D NA Y + G ++F ++E++GVV LDR
Sbjct: 362 VRENLEVGYEVL---TIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVS-TRAVLDR 417
Query: 856 EKKIMYKLSLVA----RDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
E+ Y+L + A R+ G LS+ A + I + DENDN P+F+ E+N V++ + LN
Sbjct: 418 EEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFS--EQNYVVQVPEDVGLN 475
Score = 91.9 bits (218), Expect = 2e-17
Identities = 121/449 (26%), Positives = 187/449 (41%), Gaps = 61/449 (13%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
IEV+ +N + + +PE++ + T ++++ A D D G N I Y
Sbjct: 447 IEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHY---------- 496
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN---LNDNISVRV 1033
S LS + V F ++ G + V L E ++ L+I A DGG +N + V V
Sbjct: 497 SILSGN---VAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSV 553
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI--------- 1084
V DVND+ P+F + + V E + + A DAD G+NA L Y +
Sbjct: 554 QVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLG 613
Query: 1085 -------QPSDT-DLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXX 1136
P+ T D PF+I +G ++V ELDRE + Y V A D+G
Sbjct: 614 GGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHG-SPPMSSSTS 672
Query: 1137 XXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTV 1196
DVNDN P F E + E + + + I G T
Sbjct: 673 VSITVLDVNDNDPVF--TQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTR 730
Query: 1197 AKVFANDTDFIGNGNGLILYSLP-QRKNQQNLGLP------SLSSTAILMVTVADVPDEV 1249
+ FA + G GLI +LP K +Q L + S TA +++ V D
Sbjct: 731 NR-FALSSQ---RGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDA---- 782
Query: 1250 EMSDKPVFISRYYELEIEEN--VNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFV 1307
+ +PVF S +Y + + E+ V + +S N + EN ++ Y I D F
Sbjct: 783 -NTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVI-----QDPVPQFR 836
Query: 1308 IDPRNGTLYLVRSPDREVKDTYEVIVRAE 1336
IDP +GT+Y + D E + Y + + A+
Sbjct: 837 IDPDSGTMYTMMELDYENQVAYTLTIMAQ 865
Score = 91.5 bits (217), Expect = 2e-17
Identities = 100/348 (28%), Positives = 152/348 (43%), Gaps = 58/348 (16%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ E+ P+GT+I L+A D D+G N +I Y V P ++ D+ G
Sbjct: 798 VSEDRPVGTSIATLSANDEDTGENARITYVIQDPV--PQFRIDPDS-------------G 842
Query: 1000 HVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNV- 1054
+ L E++ + L I A D G +D ++ + + D ND+ P F +Y ++
Sbjct: 843 TMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIF 902
Query: 1055 EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT-DLPFEISPLTGVLSVNGELDRETE 1113
E+A + +L +V ATD D G N L Y Q D D F I P +GV+ LDRE
Sbjct: 903 EDAPPSTSIL-QVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENV 961
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNF 1173
Y L +A D G D+NDN+P F E DEL
Sbjct: 962 AVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF------------EKDEL----- 1004
Query: 1174 ESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLS 1233
+ +EEN P+G+ VAK+ AND D N I+Y + + + L L+
Sbjct: 1005 ---------ELFVEENNPVGSVVAKIRANDPD--EGPNAQIMYQIVEGDMRHFFQLDLLN 1053
Query: 1234 STAILMVTV-ADVPDE----VEMSDKPVFISR--YYELEIEENVNAPV 1274
MV + +V E V+ + P+ +SR + L +++N N PV
Sbjct: 1054 GDLRAMVELDFEVRREYVLVVQATSAPL-VSRATVHILLVDQNDNPPV 1100
Score = 86.6 bits (205), Expect = 6e-16
Identities = 67/218 (30%), Positives = 100/218 (45%), Gaps = 20/218 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN+ +G ++ + A D DS +N +RY ++ A +V F +NE G
Sbjct: 362 VRENLEVGYEVLTIRASDRDSPINANLRY-----------RVLGGAWDV---FQLNESSG 407
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGN----LNDNISVRVFVKDVNDHFPVFKKTWYNFN 1053
V L E +E++L + A D G L+ +V + V+D ND++P F + Y
Sbjct: 408 VVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQ 467
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETE 1113
V E + +V ATD D GQNA + Y I + F + L+G+L V LD E
Sbjct: 468 VPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDV 527
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
KY L++ A+D G DVNDN P F
Sbjct: 528 QKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIF 565
Score = 83.8 bits (198), Expect = 4e-15
Identities = 53/163 (32%), Positives = 80/163 (49%), Gaps = 8/163 (4%)
Query: 223 QDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLN 282
+D + + Y+L GN R F+L S G + L LD + Q +VL V AS
Sbjct: 712 RDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQ---YVLAVTAS--- 765
Query: 283 NPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFT 342
+ ++ A V I + D N + P F+ Y +S+ E+ P G S+ + A D+D GEN T
Sbjct: 766 DGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARIT 825
Query: 343 YQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
Y + DP F IDP SG T+ LD E + + + A++
Sbjct: 826 YVIQDPVPQFRIDPDSG--TMYTMMELDYENQVAYTLTIMAQD 866
Score = 79.8 bits (188), Expect = 7e-14
Identities = 110/462 (23%), Positives = 186/462 (40%), Gaps = 45/462 (9%)
Query: 461 PSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTV 520
P Y+ ++ N GT+I ++ A G+ V Y ++ + F+I+ TG V
Sbjct: 246 PMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAV 305
Query: 521 SVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPY 578
S E + H L V+A D P R + +T+ V K P F + Y
Sbjct: 306 STDSVLDRETKETHVLRVKAVDYSTPP---RSATTYITVLV----KDTNDHSPVFEQSEY 358
Query: 579 EFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLS 636
V N+ +G V IR +D ++ Y +L G + F + E SGV++ L
Sbjct: 359 RERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWD--VFQLNESSGVVSTRAVLD 416
Query: 637 RYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKEN-SAGA 695
R Y A + N ++ ++V DE + + + V E+
Sbjct: 417 REEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNT 476
Query: 696 AIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMT 755
A+ ++ T+ G + + I + + G + PLD E Y ++
Sbjct: 477 AVLRVQATDRDQ--GQNAA-IHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLS 533
Query: 756 VIAEFN--KGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIK 813
+ A+ +I+ +G+ V++ + D NDN P+F + ++ ++EN +G + I+
Sbjct: 534 IKAQDGGRPPLINSSGV--VSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVH---IQ 588
Query: 814 ATDADEGTNALFMY-------TLFGEGKE-----------MFDVDENTGVVKFIGDSLDR 855
A DAD G NA Y T G G F + ++G + + LDR
Sbjct: 589 AVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAE-LDR 647
Query: 856 EKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
E+ Y + A D G +SS + I + D NDN P F Q
Sbjct: 648 EEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQ 689
Score = 79.0 bits (186), Expect = 1e-13
Identities = 114/457 (24%), Positives = 187/457 (40%), Gaps = 41/457 (8%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
EN P GT I++L+A G ++ Y + ++ S+ YF I+ G V
Sbjct: 256 ENEPAGTLILQLHAHYTIEGEEERVSY-YMEGLFDERSR---------GYFRIDSATGAV 305
Query: 1002 IVARSLPPESEFR--LNISALDGGNLNDNIS--VRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
L E++ L + A+D + + + V VKD NDH PVF+++ Y V E
Sbjct: 306 STDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVREN 365
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYI 1117
+ + A+D D NANL Y + D+ F+++ +GV+S LDRE +Y
Sbjct: 366 LEVGYEVLTIRASDRDSPINANLRYRVLGGAWDV-FQLNESSGVVSTRAVLDREEAAEYQ 424
Query: 1118 LTVVARDNGXX-XXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESV 1176
L V A D G D NDN P+F + +++ + ++
Sbjct: 425 LLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQAT 484
Query: 1177 MMIPVYKATIEENAPIGTTVAKVFAND----TDFIG--NGNGLILYSLPQRKNQQNLGLP 1230
A I + G + + + D I + + YSL K Q P
Sbjct: 485 DRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSL-SIKAQDGGRPP 543
Query: 1231 SLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEHYENF 1288
++S+ ++ V V DV D ++P+F+S ++ + ENV PV + + EN
Sbjct: 544 LINSSGVVSVQVLDVND-----NEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENA 598
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVK---DTYEVIVRAERQKYSRELP 1345
++ Y ++ D TF+ G +PD + + + V AE + E+
Sbjct: 599 RLHYRLV-----DTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDR--EEVE 651
Query: 1346 HMIYPV-AEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
H + V A D V + + DVNDN P FT
Sbjct: 652 HYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFT 688
Score = 78.2 bits (184), Expect = 2e-13
Identities = 43/135 (31%), Positives = 71/135 (52%), Gaps = 4/135 (2%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D+D G A + Y ++SGN F L S++G L + LD + ++Q + ++ Q
Sbjct: 481 VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFE---DVQKYSLSIKAQ 537
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
PL + V +++LD+NDN P F + +++EN+P G+ V+ + A D D GE
Sbjct: 538 DGG-RPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGE 596
Query: 338 NGEFTYQLDDPKGAF 352
N Y+L D F
Sbjct: 597 NARLHYRLVDTASTF 611
Score = 70.9 bits (166), Expect = 3e-11
Identities = 83/350 (23%), Positives = 148/350 (42%), Gaps = 30/350 (8%)
Query: 444 NVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTS 503
+V + + DAN + PVF S+ Y S+ + VGT I + A D D G+N + Y +Q
Sbjct: 774 HVLINVTDANTHRPVFQSSH-YTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDP- 831
Query: 504 NLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTR 561
F+I+P++GT+ E + + L + A D +L ++ ++
Sbjct: 832 ----VPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDAN- 886
Query: 562 GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLHGYEEGVP 619
+ P F+ Y+ + + TS+ Q+ D + + Y G +
Sbjct: 887 ------DNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGD 940
Query: 620 FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN--LSIVTNATVHVVDVNDERGVLL 677
F +E SGVI L R N +Y+ A+A+ + LS V ++D+ND +
Sbjct: 941 FYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFE 1000
Query: 678 KGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDG 736
K +F + N G+ + +I + + + I + D+ + +G
Sbjct: 1001 KDELE--LFVEENNPVGSVVAKIRANDPDE---GPNAQIMYQIV-EGDMRHFFQLDLLNG 1054
Query: 737 TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
+ LD E R Y + V A + ++S A ++ I + D+NDNPPV
Sbjct: 1055 DLRAMVELDFEVRREYVLVVQAT-SAPLVSRATVH---ILLVDQNDNPPV 1100
Score = 70.1 bits (164), Expect = 6e-11
Identities = 60/205 (29%), Positives = 98/205 (47%), Gaps = 11/205 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I A D+D + A LRY ++ G +F L+ +G + LD + +A + L V+
Sbjct: 375 IRASDRDSPINANLRYRVLGGA-WDVFQLNESSGVVSTRAVLDRE-----EAAEYQLLVE 428
Query: 278 AS-QLNNPLK-TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
A+ Q NP +A A V IE+ D NDN P+F Y + + E++ +VL+V ATD+DQ
Sbjct: 429 ANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQ 488
Query: 336 GENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
G+N Y + + G F + SG L V N + SL +K P + +
Sbjct: 489 GQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSS 548
Query: 394 FADSQRIAKWR-RQPLETNAPLEKT 417
S ++ +P+ ++P + T
Sbjct: 549 GVVSVQVLDVNDNEPIFVSSPFQAT 573
Score = 67.3 bits (157), Expect = 4e-10
Identities = 45/152 (29%), Positives = 73/152 (48%), Gaps = 8/152 (5%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
L R F +DS G++ + LD + + T VL+V+A + P ++A + +
Sbjct: 287 LFDERSRGYFRIDSATGAVSTDSVLDRETKE-----THVLRVKAVDYSTPPRSATTYITV 341
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ-LDDPKGAFS 353
+ D ND+ P FE Y + ENL G+ VL + A+D+D N Y+ L F
Sbjct: 342 LVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQ 401
Query: 354 IDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
++ SG V + VLDRE + ++ V A +
Sbjct: 402 LNESSG--VVSTRAVLDREEAAEYQLLVEAND 431
Score = 66.5 bits (155), Expect = 7e-10
Identities = 50/169 (29%), Positives = 79/169 (46%), Gaps = 9/169 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKL-FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D+D G L Y G+D F ++ +G + ++ LD E+ N + L V
Sbjct: 914 VSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLD--RENVAVYNLWALAV 971
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
PL +A +++ +LD+NDN P FE D + + EN P G V ++ A D D+G
Sbjct: 972 DRGS-PTPL-SASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEG 1029
Query: 337 ENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
N + YQ+ D + F +D +G +R LD E + V A
Sbjct: 1030 PNAQIMYQIVEGDMRHFFQLDLLNG--DLRAMVELDFEVRREYVLVVQA 1076
Score = 64.9 bits (151), Expect = 2e-09
Identities = 61/237 (25%), Positives = 107/237 (45%), Gaps = 17/237 (7%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L + V ++VT+LD NDN P+F L E ++ N VG+V+ K++A DPD G N ++Y
Sbjct: 979 LSASVEIQVTILDINDNAPMFEKDEL-ELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQ 1037
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVT 556
+ + F+++ G + E R + L V+A+ P S A V
Sbjct: 1038 IVEGD---MRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPL------VSRATVH 1088
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSV-GQIRVNDAFEQNDVSYDLLHGYE 615
I + N P +PDF + + T V G I +D + ++Y + G E
Sbjct: 1089 ILLV-DQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNE 1147
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDE 672
+ ++ +G + + DL NRP+ V++ + + S+ T+ V + D+
Sbjct: 1148 LRL-LLLDPATGELQLSRDLDN-NRPLEALMEVSVSDGIH-SVTAFCTLRVTIITDD 1201
Score = 61.7 bits (143), Expect = 2e-08
Identities = 52/170 (30%), Positives = 81/170 (47%), Gaps = 16/170 (9%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I A D D G A + Y+++ G+ R F LD +NG L ELD + +VL VQ
Sbjct: 1021 IRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRRE-----YVLVVQ 1075
Query: 278 ASQLNNPLKTAQARVEIELLDLNDN---LPEFEVDFYNISIVENLPNGFS---VLQVMAT 331
A+ PL ++A V I L+D NDN LP+F++ F N V N N F + + A
Sbjct: 1076 ATSA--PL-VSRATVHILLVDQNDNPPVLPDFQILFNN--YVTNKSNSFPTGVIGCIPAH 1130
Query: 332 DKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKV 381
D D ++ +T+ + +DP +G L + +R + + + V
Sbjct: 1131 DPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSV 1180
Score = 47.2 bits (107), Expect = 5e-04
Identities = 81/343 (23%), Positives = 130/343 (37%), Gaps = 37/343 (10%)
Query: 71 GAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPI----GP 126
G +SA +V + +ED NDN P F + Y V V E G + + G
Sbjct: 433 GRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPE--DVGLNTAVLRVQATDRDQGQ 490
Query: 127 SLTIPLTVPRG-----LTIFKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKP 180
+ I ++ G + D P YS+ + D G L +S
Sbjct: 491 NAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGV 550
Query: 181 VLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEP-IHAIDQDLGVGATLRYELISGN 239
V + +VLD + + F + + + +P I A+D D G A L Y L+
Sbjct: 551 VSV--QVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTA 608
Query: 240 DRKL---------------FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNP 284
L F N S ++ +LD E + + V+A +P
Sbjct: 609 STFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDRE---EVEHYSFGVEAVDHGSP 665
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
++ V I +LD+NDN P F Y + + E+ G SVL + A D+D N TYQ
Sbjct: 666 PMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQ 723
Query: 345 L--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
L + + F++ + G + LD + + V A +
Sbjct: 724 LTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD 766
Score = 39.1 bits (87), Expect = 0.12
Identities = 29/97 (29%), Positives = 46/97 (47%), Gaps = 9/97 (9%)
Query: 305 EFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD-----PKGAFSIDPRSG 359
+F + Y +++ EN P G +LQ+ A +GE +Y ++ +G F ID +G
Sbjct: 244 KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
Query: 360 WLTVRNQTVLDREAHSS--LRMKVYAKETNPSVVGTF 394
V +VLDRE + LR+K T P T+
Sbjct: 304 --AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTY 338
Score = 34.3 bits (75), Expect = 3.4
Identities = 17/39 (43%), Positives = 23/39 (58%), Gaps = 1/39 (2%)
Query: 1441 ATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAAL 1479
A D D G NA I Y ++ + P+F IDP SGT+ + L
Sbjct: 813 ANDEDTGENARITY-VIQDPVPQFRIDPDSGTMYTMMEL 850
>AL021392-2|CAI20967.1| 3014|Homo sapiens cadherin, EGF LAG seven-pass
G-type receptor 1 (flamingo homolog, Drosophila) protein.
Length = 3014
Score = 144 bits (350), Expect = 2e-33
Identities = 190/705 (26%), Positives = 306/705 (43%), Gaps = 98/705 (13%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V +LD NDN P+FV S+ ++ ++ N +G + ++AVD D G+N + Y L T++
Sbjct: 551 VSVQVLDVNDNEPIFV-SSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTAS 609
Query: 505 L--------------TITSPFKINPNTGTVSV-AESPILEGRHALF-VEASDQPANPSER 548
T PF+I+ ++G ++V AE E H F VEA D + P
Sbjct: 610 TFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSS 669
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSY 608
S+++ ++V N D P F YE + + +G+SV ++ D + ++Y
Sbjct: 670 STSVSITVLDV------NDND-PVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITY 722
Query: 609 DLLHGYEEGVPFAVEER--SGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHV 666
L G FA+ + G+IT+ L Y A + S + ++V
Sbjct: 723 QLTGGNTRN-RFALSSQRGGGLITLALPLDYKQEQQYVLAVTA--SDGTRSHTAHVLINV 779
Query: 667 VDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTG-NVRFLIANQQD 725
D N R V + +H + ++ G +I + S TG N R Q
Sbjct: 780 TDANTHRPVF-QSSHYTVSVS-EDRPVGTSIATL------SANDEDTGENARITYVIQDP 831
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP 785
V + GT++T LD E + Y +T++A+ N G+ + + I I D NDN P
Sbjct: 832 VPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDN-GIPQKSDTTTLEILILDANDNAP 890
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG--EGKEMFDVDENT 843
F Y+G I E++ T I + ATD D G N +YT G +G F ++ +
Sbjct: 891 QFLWDFYQGSIFEDAPPSTSILQ---VSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTS 947
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTGG---LSSEAELIIMIGDENDNKPEFNQIEENS 900
GV++ LDRE +Y L +A D G LS+ E+ + I D NDN P F E
Sbjct: 948 GVIR-TQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF----EKD 1002
Query: 901 KVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDS 960
++ + E N G + +++ A D D+ GP I I G + LDL
Sbjct: 1003 ELELFVEE--NNPVGSVVAKIR-----ANDPDE-GPNAQIMYQIVEG-DMRHFFQLDL-- 1051
Query: 961 GLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISAL 1020
LNG +R + + D EV+R +V+ V+ A S P S ++I +
Sbjct: 1052 -LNGDLR-----------AMVELD-FEVRREYVL------VVQATSAPLVSRATVHILLV 1092
Query: 1021 DGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA-QYTRRVLGKVDATDADFGQNAN 1079
D NDN V P F+ + N+ ++ + V+G + A D D + N
Sbjct: 1093 D---QNDNPPV----------LPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLN 1139
Query: 1080 LTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARD 1124
T F+Q ++ L + P TG L ++ +LD + ++ V D
Sbjct: 1140 YT-FVQGNELRL-LLLDPATGELQLSRDLDNNRPLEALMEVSVSD 1182
Score = 127 bits (306), Expect = 3e-28
Identities = 130/471 (27%), Positives = 212/471 (45%), Gaps = 38/471 (8%)
Query: 430 ENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDL 489
E +++ + S +V +T+LD NDN+PVF YE + +A VG+ + ++A D D
Sbjct: 658 EAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPT-YELRLNEDAAVGSSVLTLQARDRDA 716
Query: 490 GQNGMVLYDLQRTSNLTITSPFKINPNTG----TVSVAESPILEGRHALFVEASDQPANP 545
N ++ Y L T T + F ++ G T+++ E ++ L V ASD
Sbjct: 717 --NSVITYQL--TGGNT-RNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT--- 768
Query: 546 SERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND 605
R A V I VT P F + Y V + +GTS+ + ND E
Sbjct: 769 ---RSHTAHVLINVTDANTHR----PVFQSSHYTVSVSEDRPVGTSIATLSAND--EDTG 819
Query: 606 VSYDLLHGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA--NLSIVTNA 662
+ + + ++ VP F ++ SG + + +L N+ Y +A Q+N S T
Sbjct: 820 ENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMA-QDNGIPQKSDTTTL 878
Query: 663 TVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIAN 722
+ ++D ND L + IF ++ +I Q+ T+ S G + +
Sbjct: 879 EILILDANDNAPQFLWDFYQGSIF--EDAPPSTSILQVSATDRDS---GPNGRLLYTFQG 933
Query: 723 QQDVTDDIAIAE-DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
D D I G I TQ+ LDRE VY + +A + ++ + I D N
Sbjct: 934 GDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDIN 993
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVD 840
DN P+FE E F+ EN+ +G+ + I+A D DEG NA MY + G+ + F +D
Sbjct: 994 DNAPMFEKDELELFVEENNPVGSVVAK---IRANDPDEGPNAQIMYQIVEGDMRHFFQLD 1050
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKP 891
G ++ + + LD E + Y L +V + L S A + I++ D+NDN P
Sbjct: 1051 LLNGDLRAMVE-LDFEVRREYVL-VVQATSAPLVSRATVHILLVDQNDNPP 1099
Score = 99.5 bits (237), Expect = 8e-20
Identities = 122/489 (24%), Positives = 216/489 (44%), Gaps = 44/489 (8%)
Query: 428 KTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDP 487
+ + ++Y + + V + D ND++PVF S Y ++ N +VG + ++A D
Sbjct: 322 RVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSE-YRERVRENLEVGYEVLTIRASDR 380
Query: 488 DLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANP 545
D N + Y + + F++N ++G VS E + L VEA+DQ NP
Sbjct: 381 DSPINANLRYRVLGGA----WDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNP 436
Query: 546 SERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE-QN 604
+ A V IEV + + P F Y V +VG+ T+V +++ D + QN
Sbjct: 437 GPLS-ATATVYIEV----EDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQN 491
Query: 605 -DVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNA- 662
+ Y +L G G F + SG++ V++ L + Y ++ Q+ ++ ++
Sbjct: 492 AAIHYSILSGNVAG-QFYLHSLSGILDVINPLDFEDVQKYSL-SIKAQDGGRPPLINSSG 549
Query: 663 --TVHVVDVNDERGVLLKG-------AHSPI---IFHVKENSAGAAIGQIFHTNM----S 706
+V V+DVND + + + P+ + H++ A + H + S
Sbjct: 550 VVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTAS 609
Query: 707 SIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVIS 766
+ G G+ + A D I G I LDRE+ + Y V A + G
Sbjct: 610 TFLGGGSAGPK-NPAPTPDFPFQIH-NSSGWITVCAELDREEVEHYSFGVEA-VDHGSPP 666
Query: 767 GAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFM 826
+ V+I + D NDN PVF TYE + E++ +G+ + ++A D D N++
Sbjct: 667 MSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVL---TLQARDRD--ANSVIT 721
Query: 827 YTLF-GEGKEMFDV-DENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIG 884
Y L G + F + + G + + LD +++ Y L++ A D G S A ++I +
Sbjct: 722 YQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD-GTRSHTAHVLINVT 780
Query: 885 DENDNKPEF 893
D N ++P F
Sbjct: 781 DANTHRPVF 789
Score = 98.3 bits (234), Expect = 2e-19
Identities = 116/437 (26%), Positives = 192/437 (43%), Gaps = 68/437 (15%)
Query: 929 LDVDQLGPLFLIP-------ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LDV+ P+F P E+ +G++++ L A D D+ N I Y+
Sbjct: 678 LDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA--NSVITYQLTGG-------- 727
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLNISALDGGNLNDNISVRVFVKD 1037
+ F ++ + G ++ +LP E ++ L ++A DG + V + V D
Sbjct: 728 -----NTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR-SHTAHVLINVTD 781
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISP 1097
N H PVF+ + Y +V E + + + A D D G+NA +TY IQ D F I P
Sbjct: 782 ANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ--DPVPQFRIDP 839
Query: 1098 LTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDEL 1157
+G + ELD E + Y LT++A+DNG D NDN+P+F
Sbjct: 840 DSGTMYTMMELDYENQVAYTLTIMAQDNG-IPQKSDTTTLEILILDANDNAPQFL----- 893
Query: 1158 LEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDT---DF-IGNGNGL 1213
W + + S ++ V AT ++ P G + D DF I +G+
Sbjct: 894 --WDFYQGSIFEDAP-PSTSILQV-SATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGV 949
Query: 1214 ILYSLPQRKNQQNL------------GLPS-LSSTAILMVTVADVPDEVEMSDKPVFISR 1260
I +R +++N+ G P+ LS++ + VT+ D+ D + P+F
Sbjct: 950 I--RTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDIND-----NAPMFEKD 1002
Query: 1261 YYELEIEEN--VNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLV 1318
EL +EEN V + V + N + N ++ Y I+ + D+R F +D NG L +
Sbjct: 1003 ELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV---EGDMRHFFQLDLLNGDLRAM 1059
Query: 1319 RSPDREVKDTYEVIVRA 1335
D EV+ Y ++V+A
Sbjct: 1060 VELDFEVRREYVLVVQA 1076
Score = 95.5 bits (227), Expect = 1e-18
Identities = 91/314 (28%), Positives = 136/314 (43%), Gaps = 31/314 (9%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPL 132
G +S+ SV++ + DVNDN P+F Y + ++E G + I
Sbjct: 663 GSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITY 722
Query: 133 TVPRGLTIFKDIRAFDRDK-------PNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR 185
+ G T + + R P + Y + DG SH +L+
Sbjct: 723 QLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG----TRSHTAHVLIN 778
Query: 186 KVLDYDAGDKEFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDR 241
V D + FQ V ++ + + I + A D+D G A + Y + +
Sbjct: 779 -VTDANTHRPVFQSSHYTVSVSEDRPVGTSIA---TLSANDEDTGENARITY--VIQDPV 832
Query: 242 KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLND 301
F +D +G+++ ELD + N A T + Q + + P K+ +EI +LD ND
Sbjct: 833 PQFRIDPDSGTMYTMMELDYE---NQVAYTLTIMAQDNGI--PQKSDTTTLEILILDAND 887
Query: 302 NLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL---DDPKGAFSIDPRS 358
N P+F DFY SI E+ P S+LQV ATD+D G NG Y DD G F I+P S
Sbjct: 888 NAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTS 947
Query: 359 GWLTVRNQTVLDRE 372
G +R Q LDRE
Sbjct: 948 G--VIRTQRRLDRE 959
Score = 93.5 bits (222), Expect = 5e-18
Identities = 61/180 (33%), Positives = 98/180 (54%), Gaps = 11/180 (6%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G + T LDRE ++ + + V A A Y +T+ ++D ND+ PVFE + Y
Sbjct: 303 GAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTY-ITVLVKDTNDHSPVFEQSEYRER 361
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
+ EN ++G E+ I+A+D D NA Y + G ++F ++E++GVV LDR
Sbjct: 362 VRENLEVGYEVL---TIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVS-TRAVLDR 417
Query: 856 EKKIMYKLSLVA----RDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
E+ Y+L + A R+ G LS+ A + I + DENDN P+F+ E+N V++ + LN
Sbjct: 418 EEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFS--EQNYVVQVPEDVGLN 475
Score = 91.9 bits (218), Expect = 2e-17
Identities = 121/449 (26%), Positives = 187/449 (41%), Gaps = 61/449 (13%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
IEV+ +N + + +PE++ + T ++++ A D D G N I Y
Sbjct: 447 IEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHY---------- 496
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN---LNDNISVRV 1033
S LS + V F ++ G + V L E ++ L+I A DGG +N + V V
Sbjct: 497 SILSGN---VAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSV 553
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI--------- 1084
V DVND+ P+F + + V E + + A DAD G+NA L Y +
Sbjct: 554 QVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLG 613
Query: 1085 -------QPSDT-DLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXX 1136
P+ T D PF+I +G ++V ELDRE + Y V A D+G
Sbjct: 614 GGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHG-SPPMSSSTS 672
Query: 1137 XXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTV 1196
DVNDN P F E + E + + + I G T
Sbjct: 673 VSITVLDVNDNDPVF--TQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTR 730
Query: 1197 AKVFANDTDFIGNGNGLILYSLP-QRKNQQNLGLP------SLSSTAILMVTVADVPDEV 1249
+ FA + G GLI +LP K +Q L + S TA +++ V D
Sbjct: 731 NR-FALSSQ---RGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDA---- 782
Query: 1250 EMSDKPVFISRYYELEIEEN--VNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFV 1307
+ +PVF S +Y + + E+ V + +S N + EN ++ Y I D F
Sbjct: 783 -NTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVI-----QDPVPQFR 836
Query: 1308 IDPRNGTLYLVRSPDREVKDTYEVIVRAE 1336
IDP +GT+Y + D E + Y + + A+
Sbjct: 837 IDPDSGTMYTMMELDYENQVAYTLTIMAQ 865
Score = 91.5 bits (217), Expect = 2e-17
Identities = 100/348 (28%), Positives = 152/348 (43%), Gaps = 58/348 (16%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ E+ P+GT+I L+A D D+G N +I Y V P ++ D+ G
Sbjct: 798 VSEDRPVGTSIATLSANDEDTGENARITYVIQDPV--PQFRIDPDS-------------G 842
Query: 1000 HVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNV- 1054
+ L E++ + L I A D G +D ++ + + D ND+ P F +Y ++
Sbjct: 843 TMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIF 902
Query: 1055 EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT-DLPFEISPLTGVLSVNGELDRETE 1113
E+A + +L +V ATD D G N L Y Q D D F I P +GV+ LDRE
Sbjct: 903 EDAPPSTSIL-QVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENV 961
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNF 1173
Y L +A D G D+NDN+P F E DEL
Sbjct: 962 AVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF------------EKDEL----- 1004
Query: 1174 ESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLS 1233
+ +EEN P+G+ VAK+ AND D N I+Y + + + L L+
Sbjct: 1005 ---------ELFVEENNPVGSVVAKIRANDPD--EGPNAQIMYQIVEGDMRHFFQLDLLN 1053
Query: 1234 STAILMVTV-ADVPDE----VEMSDKPVFISR--YYELEIEENVNAPV 1274
MV + +V E V+ + P+ +SR + L +++N N PV
Sbjct: 1054 GDLRAMVELDFEVRREYVLVVQATSAPL-VSRATVHILLVDQNDNPPV 1100
Score = 86.6 bits (205), Expect = 6e-16
Identities = 67/218 (30%), Positives = 100/218 (45%), Gaps = 20/218 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN+ +G ++ + A D DS +N +RY ++ A +V F +NE G
Sbjct: 362 VRENLEVGYEVLTIRASDRDSPINANLRY-----------RVLGGAWDV---FQLNESSG 407
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGN----LNDNISVRVFVKDVNDHFPVFKKTWYNFN 1053
V L E +E++L + A D G L+ +V + V+D ND++P F + Y
Sbjct: 408 VVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQ 467
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETE 1113
V E + +V ATD D GQNA + Y I + F + L+G+L V LD E
Sbjct: 468 VPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDV 527
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
KY L++ A+D G DVNDN P F
Sbjct: 528 QKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIF 565
Score = 83.8 bits (198), Expect = 4e-15
Identities = 53/163 (32%), Positives = 80/163 (49%), Gaps = 8/163 (4%)
Query: 223 QDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLN 282
+D + + Y+L GN R F+L S G + L LD + Q +VL V AS
Sbjct: 712 RDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQ---YVLAVTAS--- 765
Query: 283 NPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFT 342
+ ++ A V I + D N + P F+ Y +S+ E+ P G S+ + A D+D GEN T
Sbjct: 766 DGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARIT 825
Query: 343 YQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
Y + DP F IDP SG T+ LD E + + + A++
Sbjct: 826 YVIQDPVPQFRIDPDSG--TMYTMMELDYENQVAYTLTIMAQD 866
Score = 79.8 bits (188), Expect = 7e-14
Identities = 110/462 (23%), Positives = 186/462 (40%), Gaps = 45/462 (9%)
Query: 461 PSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTV 520
P Y+ ++ N GT+I ++ A G+ V Y ++ + F+I+ TG V
Sbjct: 246 PMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAV 305
Query: 521 SVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPY 578
S E + H L V+A D P R + +T+ V K P F + Y
Sbjct: 306 STDSVLDRETKETHVLRVKAVDYSTPP---RSATTYITVLV----KDTNDHSPVFEQSEY 358
Query: 579 EFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLS 636
V N+ +G V IR +D ++ Y +L G + F + E SGV++ L
Sbjct: 359 RERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWD--VFQLNESSGVVSTRAVLD 416
Query: 637 RYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKEN-SAGA 695
R Y A + N ++ ++V DE + + + V E+
Sbjct: 417 REEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNT 476
Query: 696 AIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMT 755
A+ ++ T+ G + + I + + G + PLD E Y ++
Sbjct: 477 AVLRVQATDRDQ--GQNAA-IHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLS 533
Query: 756 VIAEFN--KGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIK 813
+ A+ +I+ +G+ V++ + D NDN P+F + ++ ++EN +G + I+
Sbjct: 534 IKAQDGGRPPLINSSGV--VSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVH---IQ 588
Query: 814 ATDADEGTNALFMY-------TLFGEGKE-----------MFDVDENTGVVKFIGDSLDR 855
A DAD G NA Y T G G F + ++G + + LDR
Sbjct: 589 AVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAE-LDR 647
Query: 856 EKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
E+ Y + A D G +SS + I + D NDN P F Q
Sbjct: 648 EEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQ 689
Score = 79.0 bits (186), Expect = 1e-13
Identities = 114/457 (24%), Positives = 187/457 (40%), Gaps = 41/457 (8%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
EN P GT I++L+A G ++ Y + ++ S+ YF I+ G V
Sbjct: 256 ENEPAGTLILQLHAHYTIEGEEERVSY-YMEGLFDERSR---------GYFRIDSATGAV 305
Query: 1002 IVARSLPPESEFR--LNISALDGGNLNDNIS--VRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
L E++ L + A+D + + + V VKD NDH PVF+++ Y V E
Sbjct: 306 STDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVREN 365
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYI 1117
+ + A+D D NANL Y + D+ F+++ +GV+S LDRE +Y
Sbjct: 366 LEVGYEVLTIRASDRDSPINANLRYRVLGGAWDV-FQLNESSGVVSTRAVLDREEAAEYQ 424
Query: 1118 LTVVARDNGXX-XXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESV 1176
L V A D G D NDN P+F + +++ + ++
Sbjct: 425 LLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQAT 484
Query: 1177 MMIPVYKATIEENAPIGTTVAKVFAND----TDFIG--NGNGLILYSLPQRKNQQNLGLP 1230
A I + G + + + D I + + YSL K Q P
Sbjct: 485 DRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSL-SIKAQDGGRPP 543
Query: 1231 SLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEHYENF 1288
++S+ ++ V V DV D ++P+F+S ++ + ENV PV + + EN
Sbjct: 544 LINSSGVVSVQVLDVND-----NEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENA 598
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVK---DTYEVIVRAERQKYSRELP 1345
++ Y ++ D TF+ G +PD + + + V AE + E+
Sbjct: 599 RLHYRLV-----DTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDR--EEVE 651
Query: 1346 HMIYPV-AEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
H + V A D V + + DVNDN P FT
Sbjct: 652 HYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFT 688
Score = 78.2 bits (184), Expect = 2e-13
Identities = 43/135 (31%), Positives = 71/135 (52%), Gaps = 4/135 (2%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D+D G A + Y ++SGN F L S++G L + LD + ++Q + ++ Q
Sbjct: 481 VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFE---DVQKYSLSIKAQ 537
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
PL + V +++LD+NDN P F + +++EN+P G+ V+ + A D D GE
Sbjct: 538 DGG-RPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGE 596
Query: 338 NGEFTYQLDDPKGAF 352
N Y+L D F
Sbjct: 597 NARLHYRLVDTASTF 611
Score = 70.9 bits (166), Expect = 3e-11
Identities = 83/350 (23%), Positives = 148/350 (42%), Gaps = 30/350 (8%)
Query: 444 NVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTS 503
+V + + DAN + PVF S+ Y S+ + VGT I + A D D G+N + Y +Q
Sbjct: 774 HVLINVTDANTHRPVFQSSH-YTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDP- 831
Query: 504 NLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTR 561
F+I+P++GT+ E + + L + A D +L ++ ++
Sbjct: 832 ----VPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDAN- 886
Query: 562 GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLHGYEEGVP 619
+ P F+ Y+ + + TS+ Q+ D + + Y G +
Sbjct: 887 ------DNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGD 940
Query: 620 FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN--LSIVTNATVHVVDVNDERGVLL 677
F +E SGVI L R N +Y+ A+A+ + LS V ++D+ND +
Sbjct: 941 FYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFE 1000
Query: 678 KGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDG 736
K +F + N G+ + +I + + + I + D+ + +G
Sbjct: 1001 KDELE--LFVEENNPVGSVVAKIRANDPDE---GPNAQIMYQIV-EGDMRHFFQLDLLNG 1054
Query: 737 TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
+ LD E R Y + V A + ++S A ++ I + D+NDNPPV
Sbjct: 1055 DLRAMVELDFEVRREYVLVVQAT-SAPLVSRATVH---ILLVDQNDNPPV 1100
Score = 70.1 bits (164), Expect = 6e-11
Identities = 60/205 (29%), Positives = 98/205 (47%), Gaps = 11/205 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I A D+D + A LRY ++ G +F L+ +G + LD + +A + L V+
Sbjct: 375 IRASDRDSPINANLRYRVLGGA-WDVFQLNESSGVVSTRAVLDRE-----EAAEYQLLVE 428
Query: 278 AS-QLNNPLK-TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
A+ Q NP +A A V IE+ D NDN P+F Y + + E++ +VL+V ATD+DQ
Sbjct: 429 ANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQ 488
Query: 336 GENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
G+N Y + + G F + SG L V N + SL +K P + +
Sbjct: 489 GQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSS 548
Query: 394 FADSQRIAKWR-RQPLETNAPLEKT 417
S ++ +P+ ++P + T
Sbjct: 549 GVVSVQVLDVNDNEPIFVSSPFQAT 573
Score = 67.3 bits (157), Expect = 4e-10
Identities = 45/152 (29%), Positives = 73/152 (48%), Gaps = 8/152 (5%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
L R F +DS G++ + LD + + T VL+V+A + P ++A + +
Sbjct: 287 LFDERSRGYFRIDSATGAVSTDSVLDRETKE-----THVLRVKAVDYSTPPRSATTYITV 341
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ-LDDPKGAFS 353
+ D ND+ P FE Y + ENL G+ VL + A+D+D N Y+ L F
Sbjct: 342 LVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQ 401
Query: 354 IDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
++ SG V + VLDRE + ++ V A +
Sbjct: 402 LNESSG--VVSTRAVLDREEAAEYQLLVEAND 431
Score = 66.5 bits (155), Expect = 7e-10
Identities = 50/169 (29%), Positives = 79/169 (46%), Gaps = 9/169 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKL-FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D+D G L Y G+D F ++ +G + ++ LD E+ N + L V
Sbjct: 914 VSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLD--RENVAVYNLWALAV 971
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
PL +A +++ +LD+NDN P FE D + + EN P G V ++ A D D+G
Sbjct: 972 DRGS-PTPL-SASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEG 1029
Query: 337 ENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
N + YQ+ D + F +D +G +R LD E + V A
Sbjct: 1030 PNAQIMYQIVEGDMRHFFQLDLLNG--DLRAMVELDFEVRREYVLVVQA 1076
Score = 64.9 bits (151), Expect = 2e-09
Identities = 61/237 (25%), Positives = 107/237 (45%), Gaps = 17/237 (7%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L + V ++VT+LD NDN P+F L E ++ N VG+V+ K++A DPD G N ++Y
Sbjct: 979 LSASVEIQVTILDINDNAPMFEKDEL-ELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQ 1037
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVT 556
+ + F+++ G + E R + L V+A+ P S A V
Sbjct: 1038 IVEGD---MRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPL------VSRATVH 1088
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSV-GQIRVNDAFEQNDVSYDLLHGYE 615
I + N P +PDF + + T V G I +D + ++Y + G E
Sbjct: 1089 ILLV-DQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNE 1147
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDE 672
+ ++ +G + + DL NRP+ V++ + + S+ T+ V + D+
Sbjct: 1148 LRL-LLLDPATGELQLSRDLDN-NRPLEALMEVSVSDGIH-SVTAFCTLRVTIITDD 1201
Score = 61.7 bits (143), Expect = 2e-08
Identities = 52/170 (30%), Positives = 81/170 (47%), Gaps = 16/170 (9%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I A D D G A + Y+++ G+ R F LD +NG L ELD + +VL VQ
Sbjct: 1021 IRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRRE-----YVLVVQ 1075
Query: 278 ASQLNNPLKTAQARVEIELLDLNDN---LPEFEVDFYNISIVENLPNGFS---VLQVMAT 331
A+ PL ++A V I L+D NDN LP+F++ F N V N N F + + A
Sbjct: 1076 ATSA--PL-VSRATVHILLVDQNDNPPVLPDFQILFNN--YVTNKSNSFPTGVIGCIPAH 1130
Query: 332 DKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKV 381
D D ++ +T+ + +DP +G L + +R + + + V
Sbjct: 1131 DPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSV 1180
Score = 47.2 bits (107), Expect = 5e-04
Identities = 81/343 (23%), Positives = 130/343 (37%), Gaps = 37/343 (10%)
Query: 71 GAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPI----GP 126
G +SA +V + +ED NDN P F + Y V V E G + + G
Sbjct: 433 GRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPE--DVGLNTAVLRVQATDRDQGQ 490
Query: 127 SLTIPLTVPRG-----LTIFKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKP 180
+ I ++ G + D P YS+ + D G L +S
Sbjct: 491 NAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGV 550
Query: 181 VLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEP-IHAIDQDLGVGATLRYELISGN 239
V + +VLD + + F + + + +P I A+D D G A L Y L+
Sbjct: 551 VSV--QVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTA 608
Query: 240 DRKL---------------FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNP 284
L F N S ++ +LD E + + V+A +P
Sbjct: 609 STFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDRE---EVEHYSFGVEAVDHGSP 665
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
++ V I +LD+NDN P F Y + + E+ G SVL + A D+D N TYQ
Sbjct: 666 PMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQ 723
Query: 345 L--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
L + + F++ + G + LD + + V A +
Sbjct: 724 LTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD 766
Score = 39.1 bits (87), Expect = 0.12
Identities = 29/97 (29%), Positives = 46/97 (47%), Gaps = 9/97 (9%)
Query: 305 EFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD-----PKGAFSIDPRSG 359
+F + Y +++ EN P G +LQ+ A +GE +Y ++ +G F ID +G
Sbjct: 244 KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
Query: 360 WLTVRNQTVLDREAHSS--LRMKVYAKETNPSVVGTF 394
V +VLDRE + LR+K T P T+
Sbjct: 304 --AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTY 338
Score = 34.3 bits (75), Expect = 3.4
Identities = 17/39 (43%), Positives = 23/39 (58%), Gaps = 1/39 (2%)
Query: 1441 ATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAAL 1479
A D D G NA I Y ++ + P+F IDP SGT+ + L
Sbjct: 813 ANDEDTGENARITY-VIQDPVPQFRIDPDSGTMYTMMEL 850
>AF231024-1|AAF61930.1| 3014|Homo sapiens protocadherin Flamingo 2
protein.
Length = 3014
Score = 144 bits (350), Expect = 2e-33
Identities = 190/705 (26%), Positives = 306/705 (43%), Gaps = 98/705 (13%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V +LD NDN P+FV S+ ++ ++ N +G + ++AVD D G+N + Y L T++
Sbjct: 551 VSVQVLDVNDNEPIFV-SSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTAS 609
Query: 505 L--------------TITSPFKINPNTGTVSV-AESPILEGRHALF-VEASDQPANPSER 548
T PF+I+ ++G ++V AE E H F VEA D + P
Sbjct: 610 TFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSS 669
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSY 608
S+++ ++V N D P F YE + + +G+SV ++ D + ++Y
Sbjct: 670 STSVSITVLDV------NDND-PVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITY 722
Query: 609 DLLHGYEEGVPFAVEER--SGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHV 666
L G FA+ + G+IT+ L Y A + S + ++V
Sbjct: 723 QLTGGNTRN-RFALSSQRGGGLITLALPLDYKQEQQYVLAVTA--SDGTRSHTAHVLINV 779
Query: 667 VDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTG-NVRFLIANQQD 725
D N R V + +H + ++ G +I + S TG N R Q
Sbjct: 780 TDANTHRPVF-QSSHYTVSVS-EDRPVGTSIATL------SANDEDTGENARITYVIQDP 831
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP 785
V + GT++T LD E + Y +T++A+ N G+ + + I I D NDN P
Sbjct: 832 VPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDN-GIPQKSDTTTLEILILDANDNAP 890
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG--EGKEMFDVDENT 843
F Y+G I E++ T I + ATD D G N +YT G +G F ++ +
Sbjct: 891 QFLWDFYQGSIFEDAPPSTSILQ---VSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTS 947
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTGG---LSSEAELIIMIGDENDNKPEFNQIEENS 900
GV++ LDRE +Y L +A D G LS+ E+ + I D NDN P F E
Sbjct: 948 GVIR-TQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF----EKD 1002
Query: 901 KVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDS 960
++ + E N G + +++ A D D+ GP I I G + LDL
Sbjct: 1003 ELELFVEE--NNPVGSVVAKIR-----ANDPDE-GPNAQIMYQIVEG-DMRHFFQLDL-- 1051
Query: 961 GLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISAL 1020
LNG +R + + D EV+R +V+ V+ A S P S ++I +
Sbjct: 1052 -LNGDLR-----------AMVELD-FEVRREYVL------VVQATSAPLVSRATVHILLV 1092
Query: 1021 DGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA-QYTRRVLGKVDATDADFGQNAN 1079
D NDN V P F+ + N+ ++ + V+G + A D D + N
Sbjct: 1093 D---QNDNPPV----------LPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLN 1139
Query: 1080 LTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARD 1124
T F+Q ++ L + P TG L ++ +LD + ++ V D
Sbjct: 1140 YT-FVQGNELRL-LLLDPATGELQLSRDLDNNRPLEALMEVSVSD 1182
Score = 127 bits (306), Expect = 3e-28
Identities = 130/471 (27%), Positives = 212/471 (45%), Gaps = 38/471 (8%)
Query: 430 ENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDL 489
E +++ + S +V +T+LD NDN+PVF YE + +A VG+ + ++A D D
Sbjct: 658 EAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPT-YELRLNEDAAVGSSVLTLQARDRDA 716
Query: 490 GQNGMVLYDLQRTSNLTITSPFKINPNTG----TVSVAESPILEGRHALFVEASDQPANP 545
N ++ Y L T T + F ++ G T+++ E ++ L V ASD
Sbjct: 717 --NSVITYQL--TGGNT-RNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT--- 768
Query: 546 SERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND 605
R A V I VT P F + Y V + +GTS+ + ND E
Sbjct: 769 ---RSHTAHVLINVTDANTHR----PVFQSSHYTVSVSEDRPVGTSIATLSAND--EDTG 819
Query: 606 VSYDLLHGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA--NLSIVTNA 662
+ + + ++ VP F ++ SG + + +L N+ Y +A Q+N S T
Sbjct: 820 ENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMA-QDNGIPQKSDTTTL 878
Query: 663 TVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIAN 722
+ ++D ND L + IF ++ +I Q+ T+ S G + +
Sbjct: 879 EILILDANDNAPQFLWDFYQGSIF--EDAPPSTSILQVSATDRDS---GPNGRLLYTFQG 933
Query: 723 QQDVTDDIAIAE-DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
D D I G I TQ+ LDRE VY + +A + ++ + I D N
Sbjct: 934 GDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDIN 993
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVD 840
DN P+FE E F+ EN+ +G+ + I+A D DEG NA MY + G+ + F +D
Sbjct: 994 DNAPMFEKDELELFVEENNPVGSVVAK---IRANDPDEGPNAQIMYQIVEGDMRHFFQLD 1050
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKP 891
G ++ + + LD E + Y L +V + L S A + I++ D+NDN P
Sbjct: 1051 LLNGDLRAMVE-LDFEVRREYVL-VVQATSAPLVSRATVHILLVDQNDNPP 1099
Score = 99.5 bits (237), Expect = 8e-20
Identities = 122/489 (24%), Positives = 216/489 (44%), Gaps = 44/489 (8%)
Query: 428 KTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDP 487
+ + ++Y + + V + D ND++PVF S Y ++ N +VG + ++A D
Sbjct: 322 RVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSE-YRERVRENLEVGYEVLTIRASDR 380
Query: 488 DLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANP 545
D N + Y + + F++N ++G VS E + L VEA+DQ NP
Sbjct: 381 DSPINANLRYRVLGGA----WDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNP 436
Query: 546 SERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE-QN 604
+ A V IEV + + P F Y V +VG+ T+V +++ D + QN
Sbjct: 437 GPLS-ATATVYIEV----EDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQN 491
Query: 605 -DVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNA- 662
+ Y +L G G F + SG++ V++ L + Y ++ Q+ ++ ++
Sbjct: 492 AAIHYSILSGNVAG-QFYLHSLSGILDVINPLDFEDVQKYSL-SIKAQDGGRPPLINSSG 549
Query: 663 --TVHVVDVNDERGVLLKG-------AHSPI---IFHVKENSAGAAIGQIFHTNM----S 706
+V V+DVND + + + P+ + H++ A + H + S
Sbjct: 550 VVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTAS 609
Query: 707 SIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVIS 766
+ G G+ + A D I G I LDRE+ + Y V A + G
Sbjct: 610 TFLGGGSAGPK-NPAPTPDFPFQIH-NSSGWITVCAELDREEVEHYSFGVEA-VDHGSPP 666
Query: 767 GAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFM 826
+ V+I + D NDN PVF TYE + E++ +G+ + ++A D D N++
Sbjct: 667 MSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVL---TLQARDRD--ANSVIT 721
Query: 827 YTLF-GEGKEMFDV-DENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIG 884
Y L G + F + + G + + LD +++ Y L++ A D G S A ++I +
Sbjct: 722 YQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD-GTRSHTAHVLINVT 780
Query: 885 DENDNKPEF 893
D N ++P F
Sbjct: 781 DANTHRPVF 789
Score = 98.3 bits (234), Expect = 2e-19
Identities = 116/437 (26%), Positives = 192/437 (43%), Gaps = 68/437 (15%)
Query: 929 LDVDQLGPLFLIP-------ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LDV+ P+F P E+ +G++++ L A D D+ N I Y+
Sbjct: 678 LDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA--NSVITYQLTGG-------- 727
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLNISALDGGNLNDNISVRVFVKD 1037
+ F ++ + G ++ +LP E ++ L ++A DG + V + V D
Sbjct: 728 -----NTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR-SHTAHVLINVTD 781
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISP 1097
N H PVF+ + Y +V E + + + A D D G+NA +TY IQ D F I P
Sbjct: 782 ANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ--DPVPQFRIDP 839
Query: 1098 LTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDEL 1157
+G + ELD E + Y LT++A+DNG D NDN+P+F
Sbjct: 840 DSGTMYTMMELDYENQVAYTLTIMAQDNG-IPQKSDTTTLEILILDANDNAPQFL----- 893
Query: 1158 LEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDT---DF-IGNGNGL 1213
W + + S ++ V AT ++ P G + D DF I +G+
Sbjct: 894 --WDFYQGSIFEDAP-PSTSILQV-SATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGV 949
Query: 1214 ILYSLPQRKNQQNL------------GLPS-LSSTAILMVTVADVPDEVEMSDKPVFISR 1260
I +R +++N+ G P+ LS++ + VT+ D+ D + P+F
Sbjct: 950 I--RTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDIND-----NAPMFEKD 1002
Query: 1261 YYELEIEEN--VNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLV 1318
EL +EEN V + V + N + N ++ Y I+ + D+R F +D NG L +
Sbjct: 1003 ELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV---EGDMRHFFQLDLLNGDLRAM 1059
Query: 1319 RSPDREVKDTYEVIVRA 1335
D EV+ Y ++V+A
Sbjct: 1060 VELDFEVRREYVLVVQA 1076
Score = 95.5 bits (227), Expect = 1e-18
Identities = 91/314 (28%), Positives = 136/314 (43%), Gaps = 31/314 (9%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPL 132
G +S+ SV++ + DVNDN P+F Y + ++E G + I
Sbjct: 663 GSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITY 722
Query: 133 TVPRGLTIFKDIRAFDRDK-------PNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR 185
+ G T + + R P + Y + DG SH +L+
Sbjct: 723 QLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG----TRSHTAHVLIN 778
Query: 186 KVLDYDAGDKEFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDR 241
V D + FQ V ++ + + I + A D+D G A + Y + +
Sbjct: 779 -VTDANTHRPVFQSSHYTVSVSEDRPVGTSIA---TLSANDEDTGENARITY--VIQDPV 832
Query: 242 KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLND 301
F +D +G+++ ELD + N A T + Q + + P K+ +EI +LD ND
Sbjct: 833 PQFRIDPDSGTMYTMMELDYE---NQVAYTLTIMAQDNGI--PQKSDTTTLEILILDAND 887
Query: 302 NLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL---DDPKGAFSIDPRS 358
N P+F DFY SI E+ P S+LQV ATD+D G NG Y DD G F I+P S
Sbjct: 888 NAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTS 947
Query: 359 GWLTVRNQTVLDRE 372
G +R Q LDRE
Sbjct: 948 G--VIRTQRRLDRE 959
Score = 93.5 bits (222), Expect = 5e-18
Identities = 61/180 (33%), Positives = 98/180 (54%), Gaps = 11/180 (6%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G + T LDRE ++ + + V A A Y +T+ ++D ND+ PVFE + Y
Sbjct: 303 GAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTY-ITVLVKDTNDHSPVFEQSEYRER 361
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
+ EN ++G E+ I+A+D D NA Y + G ++F ++E++GVV LDR
Sbjct: 362 VRENLEVGYEVL---TIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVS-TRAVLDR 417
Query: 856 EKKIMYKLSLVA----RDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
E+ Y+L + A R+ G LS+ A + I + DENDN P+F+ E+N V++ + LN
Sbjct: 418 EEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFS--EQNYVVQVPEDVGLN 475
Score = 91.9 bits (218), Expect = 2e-17
Identities = 121/449 (26%), Positives = 187/449 (41%), Gaps = 61/449 (13%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
IEV+ +N + + +PE++ + T ++++ A D D G N I Y
Sbjct: 447 IEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHY---------- 496
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN---LNDNISVRV 1033
S LS + V F ++ G + V L E ++ L+I A DGG +N + V V
Sbjct: 497 SILSGN---VAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSV 553
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI--------- 1084
V DVND+ P+F + + V E + + A DAD G+NA L Y +
Sbjct: 554 QVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLG 613
Query: 1085 -------QPSDT-DLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXX 1136
P+ T D PF+I +G ++V ELDRE + Y V A D+G
Sbjct: 614 GGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHG-SPPMSSSTS 672
Query: 1137 XXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTV 1196
DVNDN P F E + E + + + I G T
Sbjct: 673 VSITVLDVNDNDPVF--TQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTR 730
Query: 1197 AKVFANDTDFIGNGNGLILYSLP-QRKNQQNLGLP------SLSSTAILMVTVADVPDEV 1249
+ FA + G GLI +LP K +Q L + S TA +++ V D
Sbjct: 731 NR-FALSSQ---RGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDA---- 782
Query: 1250 EMSDKPVFISRYYELEIEEN--VNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFV 1307
+ +PVF S +Y + + E+ V + +S N + EN ++ Y I D F
Sbjct: 783 -NTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVI-----QDPVPQFR 836
Query: 1308 IDPRNGTLYLVRSPDREVKDTYEVIVRAE 1336
IDP +GT+Y + D E + Y + + A+
Sbjct: 837 IDPDSGTMYTMMELDYENQVAYTLTIMAQ 865
Score = 91.5 bits (217), Expect = 2e-17
Identities = 100/348 (28%), Positives = 152/348 (43%), Gaps = 58/348 (16%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ E+ P+GT+I L+A D D+G N +I Y V P ++ D+ G
Sbjct: 798 VSEDRPVGTSIATLSANDEDTGENARITYVIQDPV--PQFRIDPDS-------------G 842
Query: 1000 HVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNV- 1054
+ L E++ + L I A D G +D ++ + + D ND+ P F +Y ++
Sbjct: 843 TMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIF 902
Query: 1055 EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT-DLPFEISPLTGVLSVNGELDRETE 1113
E+A + +L +V ATD D G N L Y Q D D F I P +GV+ LDRE
Sbjct: 903 EDAPPSTSIL-QVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENV 961
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNF 1173
Y L +A D G D+NDN+P F E DEL
Sbjct: 962 AVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF------------EKDEL----- 1004
Query: 1174 ESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLS 1233
+ +EEN P+G+ VAK+ AND D N I+Y + + + L L+
Sbjct: 1005 ---------ELFVEENNPVGSVVAKIRANDPD--EGPNAQIMYQIVEGDMRHFFQLDLLN 1053
Query: 1234 STAILMVTV-ADVPDE----VEMSDKPVFISR--YYELEIEENVNAPV 1274
MV + +V E V+ + P+ +SR + L +++N N PV
Sbjct: 1054 GDLRAMVELDFEVRREYVLVVQATSAPL-VSRATVHILLVDQNDNPPV 1100
Score = 86.6 bits (205), Expect = 6e-16
Identities = 67/218 (30%), Positives = 100/218 (45%), Gaps = 20/218 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN+ +G ++ + A D DS +N +RY ++ A +V F +NE G
Sbjct: 362 VRENLEVGYEVLTIRASDRDSPINANLRY-----------RVLGGAWDV---FQLNESSG 407
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGN----LNDNISVRVFVKDVNDHFPVFKKTWYNFN 1053
V L E +E++L + A D G L+ +V + V+D ND++P F + Y
Sbjct: 408 VVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQ 467
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETE 1113
V E + +V ATD D GQNA + Y I + F + L+G+L V LD E
Sbjct: 468 VPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDV 527
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
KY L++ A+D G DVNDN P F
Sbjct: 528 QKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIF 565
Score = 83.8 bits (198), Expect = 4e-15
Identities = 53/163 (32%), Positives = 80/163 (49%), Gaps = 8/163 (4%)
Query: 223 QDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLN 282
+D + + Y+L GN R F+L S G + L LD + Q +VL V AS
Sbjct: 712 RDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQ---YVLAVTAS--- 765
Query: 283 NPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFT 342
+ ++ A V I + D N + P F+ Y +S+ E+ P G S+ + A D+D GEN T
Sbjct: 766 DGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARIT 825
Query: 343 YQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
Y + DP F IDP SG T+ LD E + + + A++
Sbjct: 826 YVIQDPVPQFRIDPDSG--TMYTMMELDYENQVAYTLTIMAQD 866
Score = 79.8 bits (188), Expect = 7e-14
Identities = 110/462 (23%), Positives = 186/462 (40%), Gaps = 45/462 (9%)
Query: 461 PSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTV 520
P Y+ ++ N GT+I ++ A G+ V Y ++ + F+I+ TG V
Sbjct: 246 PMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAV 305
Query: 521 SVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPY 578
S E + H L V+A D P R + +T+ V K P F + Y
Sbjct: 306 STDSVLDRETKETHVLRVKAVDYSTPP---RSATTYITVLV----KDTNDHSPVFEQSEY 358
Query: 579 EFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLS 636
V N+ +G V IR +D ++ Y +L G + F + E SGV++ L
Sbjct: 359 RERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWD--VFQLNESSGVVSTRAVLD 416
Query: 637 RYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKEN-SAGA 695
R Y A + N ++ ++V DE + + + V E+
Sbjct: 417 REEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNT 476
Query: 696 AIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMT 755
A+ ++ T+ G + + I + + G + PLD E Y ++
Sbjct: 477 AVLRVQATDRDQ--GQNAA-IHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLS 533
Query: 756 VIAEFN--KGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIK 813
+ A+ +I+ +G+ V++ + D NDN P+F + ++ ++EN +G + I+
Sbjct: 534 IKAQDGGRPPLINSSGV--VSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVH---IQ 588
Query: 814 ATDADEGTNALFMY-------TLFGEGKE-----------MFDVDENTGVVKFIGDSLDR 855
A DAD G NA Y T G G F + ++G + + LDR
Sbjct: 589 AVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAE-LDR 647
Query: 856 EKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
E+ Y + A D G +SS + I + D NDN P F Q
Sbjct: 648 EEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQ 689
Score = 79.0 bits (186), Expect = 1e-13
Identities = 114/457 (24%), Positives = 187/457 (40%), Gaps = 41/457 (8%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
EN P GT I++L+A G ++ Y + ++ S+ YF I+ G V
Sbjct: 256 ENEPAGTLILQLHAHYTIEGEEERVSY-YMEGLFDERSR---------GYFRIDSATGAV 305
Query: 1002 IVARSLPPESEFR--LNISALDGGNLNDNIS--VRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
L E++ L + A+D + + + V VKD NDH PVF+++ Y V E
Sbjct: 306 STDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVREN 365
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYI 1117
+ + A+D D NANL Y + D+ F+++ +GV+S LDRE +Y
Sbjct: 366 LEVGYEVLTIRASDRDSPINANLRYRVLGGAWDV-FQLNESSGVVSTRAVLDREEAAEYQ 424
Query: 1118 LTVVARDNGXX-XXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESV 1176
L V A D G D NDN P+F + +++ + ++
Sbjct: 425 LLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQAT 484
Query: 1177 MMIPVYKATIEENAPIGTTVAKVFAND----TDFIG--NGNGLILYSLPQRKNQQNLGLP 1230
A I + G + + + D I + + YSL K Q P
Sbjct: 485 DRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSL-SIKAQDGGRPP 543
Query: 1231 SLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEHYENF 1288
++S+ ++ V V DV D ++P+F+S ++ + ENV PV + + EN
Sbjct: 544 LINSSGVVSVQVLDVND-----NEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENA 598
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVK---DTYEVIVRAERQKYSRELP 1345
++ Y ++ D TF+ G +PD + + + V AE + E+
Sbjct: 599 RLHYRLV-----DTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDR--EEVE 651
Query: 1346 HMIYPV-AEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
H + V A D V + + DVNDN P FT
Sbjct: 652 HYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFT 688
Score = 78.2 bits (184), Expect = 2e-13
Identities = 43/135 (31%), Positives = 71/135 (52%), Gaps = 4/135 (2%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D+D G A + Y ++SGN F L S++G L + LD + ++Q + ++ Q
Sbjct: 481 VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFE---DVQKYSLSIKAQ 537
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
PL + V +++LD+NDN P F + +++EN+P G+ V+ + A D D GE
Sbjct: 538 DGG-RPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGE 596
Query: 338 NGEFTYQLDDPKGAF 352
N Y+L D F
Sbjct: 597 NARLHYRLVDTASTF 611
Score = 70.9 bits (166), Expect = 3e-11
Identities = 83/350 (23%), Positives = 148/350 (42%), Gaps = 30/350 (8%)
Query: 444 NVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTS 503
+V + + DAN + PVF S+ Y S+ + VGT I + A D D G+N + Y +Q
Sbjct: 774 HVLINVTDANTHRPVFQSSH-YTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDP- 831
Query: 504 NLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTR 561
F+I+P++GT+ E + + L + A D +L ++ ++
Sbjct: 832 ----VPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDAN- 886
Query: 562 GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLHGYEEGVP 619
+ P F+ Y+ + + TS+ Q+ D + + Y G +
Sbjct: 887 ------DNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGD 940
Query: 620 FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN--LSIVTNATVHVVDVNDERGVLL 677
F +E SGVI L R N +Y+ A+A+ + LS V ++D+ND +
Sbjct: 941 FYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFE 1000
Query: 678 KGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDG 736
K +F + N G+ + +I + + + I + D+ + +G
Sbjct: 1001 KDELE--LFVEENNPVGSVVAKIRANDPDE---GPNAQIMYQIV-EGDMRHFFQLDLLNG 1054
Query: 737 TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
+ LD E R Y + V A + ++S A ++ I + D+NDNPPV
Sbjct: 1055 DLRAMVELDFEVRREYVLVVQAT-SAPLVSRATVH---ILLVDQNDNPPV 1100
Score = 70.1 bits (164), Expect = 6e-11
Identities = 60/205 (29%), Positives = 98/205 (47%), Gaps = 11/205 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I A D+D + A LRY ++ G +F L+ +G + LD + +A + L V+
Sbjct: 375 IRASDRDSPINANLRYRVLGGA-WDVFQLNESSGVVSTRAVLDRE-----EAAEYQLLVE 428
Query: 278 AS-QLNNPLK-TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
A+ Q NP +A A V IE+ D NDN P+F Y + + E++ +VL+V ATD+DQ
Sbjct: 429 ANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQ 488
Query: 336 GENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
G+N Y + + G F + SG L V N + SL +K P + +
Sbjct: 489 GQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSS 548
Query: 394 FADSQRIAKWR-RQPLETNAPLEKT 417
S ++ +P+ ++P + T
Sbjct: 549 GVVSVQVLDVNDNEPIFVSSPFQAT 573
Score = 67.3 bits (157), Expect = 4e-10
Identities = 45/152 (29%), Positives = 73/152 (48%), Gaps = 8/152 (5%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
L R F +DS G++ + LD + + T VL+V+A + P ++A + +
Sbjct: 287 LFDERSRGYFRIDSATGAVSTDSVLDRETKE-----THVLRVKAVDYSTPPRSATTYITV 341
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ-LDDPKGAFS 353
+ D ND+ P FE Y + ENL G+ VL + A+D+D N Y+ L F
Sbjct: 342 LVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQ 401
Query: 354 IDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
++ SG V + VLDRE + ++ V A +
Sbjct: 402 LNESSG--VVSTRAVLDREEAAEYQLLVEAND 431
Score = 66.5 bits (155), Expect = 7e-10
Identities = 50/169 (29%), Positives = 79/169 (46%), Gaps = 9/169 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKL-FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D+D G L Y G+D F ++ +G + ++ LD E+ N + L V
Sbjct: 914 VSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLD--RENVAVYNLWALAV 971
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
PL +A +++ +LD+NDN P FE D + + EN P G V ++ A D D+G
Sbjct: 972 DRGS-PTPL-SASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEG 1029
Query: 337 ENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
N + YQ+ D + F +D +G +R LD E + V A
Sbjct: 1030 PNAQIMYQIVEGDMRHFFQLDLLNG--DLRAMVELDFEVRREYVLVVQA 1076
Score = 64.9 bits (151), Expect = 2e-09
Identities = 61/237 (25%), Positives = 107/237 (45%), Gaps = 17/237 (7%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L + V ++VT+LD NDN P+F L E ++ N VG+V+ K++A DPD G N ++Y
Sbjct: 979 LSASVEIQVTILDINDNAPMFEKDEL-ELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQ 1037
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVT 556
+ + F+++ G + E R + L V+A+ P S A V
Sbjct: 1038 IVEGD---MRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPL------VSRATVH 1088
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSV-GQIRVNDAFEQNDVSYDLLHGYE 615
I + N P +PDF + + T V G I +D + ++Y + G E
Sbjct: 1089 ILLV-DQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNE 1147
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDE 672
+ ++ +G + + DL NRP+ V++ + + S+ T+ V + D+
Sbjct: 1148 LRL-LLLDPATGELQLSRDLDN-NRPLEALMEVSVSDGIH-SVTAFCTLRVTIITDD 1201
Score = 61.7 bits (143), Expect = 2e-08
Identities = 52/170 (30%), Positives = 81/170 (47%), Gaps = 16/170 (9%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I A D D G A + Y+++ G+ R F LD +NG L ELD + +VL VQ
Sbjct: 1021 IRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRRE-----YVLVVQ 1075
Query: 278 ASQLNNPLKTAQARVEIELLDLNDN---LPEFEVDFYNISIVENLPNGFS---VLQVMAT 331
A+ PL ++A V I L+D NDN LP+F++ F N V N N F + + A
Sbjct: 1076 ATSA--PL-VSRATVHILLVDQNDNPPVLPDFQILFNN--YVTNKSNSFPTGVIGCIPAH 1130
Query: 332 DKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKV 381
D D ++ +T+ + +DP +G L + +R + + + V
Sbjct: 1131 DPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSV 1180
Score = 47.2 bits (107), Expect = 5e-04
Identities = 81/343 (23%), Positives = 130/343 (37%), Gaps = 37/343 (10%)
Query: 71 GAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPI----GP 126
G +SA +V + +ED NDN P F + Y V V E G + + G
Sbjct: 433 GRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPE--DVGLNTAVLRVQATDRDQGQ 490
Query: 127 SLTIPLTVPRG-----LTIFKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKP 180
+ I ++ G + D P YS+ + D G L +S
Sbjct: 491 NAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGV 550
Query: 181 VLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEP-IHAIDQDLGVGATLRYELISGN 239
V + +VLD + + F + + + +P I A+D D G A L Y L+
Sbjct: 551 VSV--QVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTA 608
Query: 240 DRKL---------------FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNP 284
L F N S ++ +LD E + + V+A +P
Sbjct: 609 STFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDRE---EVEHYSFGVEAVDHGSP 665
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
++ V I +LD+NDN P F Y + + E+ G SVL + A D+D N TYQ
Sbjct: 666 PMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQ 723
Query: 345 L--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
L + + F++ + G + LD + + V A +
Sbjct: 724 LTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD 766
Score = 39.1 bits (87), Expect = 0.12
Identities = 29/97 (29%), Positives = 46/97 (47%), Gaps = 9/97 (9%)
Query: 305 EFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD-----PKGAFSIDPRSG 359
+F + Y +++ EN P G +LQ+ A +GE +Y ++ +G F ID +G
Sbjct: 244 KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
Query: 360 WLTVRNQTVLDREAHSS--LRMKVYAKETNPSVVGTF 394
V +VLDRE + LR+K T P T+
Sbjct: 304 --AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTY 338
Score = 34.3 bits (75), Expect = 3.4
Identities = 17/39 (43%), Positives = 23/39 (58%), Gaps = 1/39 (2%)
Query: 1441 ATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAAL 1479
A D D G NA I Y ++ + P+F IDP SGT+ + L
Sbjct: 813 ANDEDTGENARITY-VIQDPVPQFRIDPDSGTMYTMMEL 850
>BC065284-1|AAH65284.1| 1381|Homo sapiens CDH23 protein protein.
Length = 1381
Score = 143 bits (346), Expect = 5e-33
Identities = 215/799 (26%), Positives = 316/799 (39%), Gaps = 125/799 (15%)
Query: 403 WRRQPLETNAPLEKTT-YVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVP 461
W RQPL+ E T + D G T VN++V D NDN P F
Sbjct: 88 WLRQPLDRETKSEFTVEFSVSDHQGVITRK-----------VNIQVG--DVNDNAPTF-H 133
Query: 462 SNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVS 521
+ Y + N VGT I V A DPDLG G VLY Q S F I+ G V+
Sbjct: 134 NQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF-----FAIDSARGIVT 188
Query: 522 VAESPILEGRHA--LFVEASDQP-ANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPY 578
V E A L V A+DQ P +LA++ +V + P F+ PY
Sbjct: 189 VIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV-------QDMDPIFINLPY 241
Query: 579 EFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLS 636
+ + GT+V I D + Y ++ G + FA++ SGV+T+ L
Sbjct: 242 STNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSI-FALDYISGVLTLNGLLD 300
Query: 637 RYNRPMYDFEAVALQENANLS---------IVTNATVHVVDVNDERGVLLKGAHSPIIFH 687
R N P+Y + + L+ + T + V+D+ND +S I
Sbjct: 301 REN-PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITE 359
Query: 688 VKENSAGAAIG-QIFH-------TNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIF 739
+ + + Q+ +M +Y G + F+I+ + D I
Sbjct: 360 LAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIIS-----PTSVQGKADIRIR 414
Query: 740 TQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMEN 799
PLD E D Y + A N+ V G +V I + +ENDN P+F Y + EN
Sbjct: 415 VAIPLDYETVDRYDFDLFA--NESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYEN 472
Query: 800 SKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKI 859
+GT + + ATD D GT FGE V F D DR
Sbjct: 473 VTVGTSVLT---VLATDNDAGT--------FGE------------VSYFFSDDPDR---- 505
Query: 860 MYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTII 919
+ L +DTG LI++I + ++ I+ + I R+ T G I
Sbjct: 506 -FSLD---KDTG-------LIMLIA-----RLDYELIQRFTLTIIARDGGGEETTGRVRI 549
Query: 920 EVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPS 979
V N + + + EN P T +++L A D DS N QI Y S
Sbjct: 550 NVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITY----------S 599
Query: 980 KLSADALEVKRYFVINERHGHVIVARSLPPESE------FRLNISALDGGN--LNDNISV 1031
+SA A YF I+ G+ +++ S P + E L + A+D GN LN + V
Sbjct: 600 IVSASAFG--SYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPV 657
Query: 1032 RVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDL 1091
+ V D ND+ P F K Y +V E + ++ATD D + I +
Sbjct: 658 TIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST 717
Query: 1092 PFEISPLTGVLSVNGELDRETEDKYILTVVARDNG-XXXXXXXXXXXXXXXXDVNDNSPK 1150
F I+ +G ++ LDRET+ +YIL V A D G D+NDN P
Sbjct: 718 QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
Query: 1151 FY---AFDELLEWKHPEAD 1166
+ + L+E P++D
Sbjct: 778 WKDAPYYINLVEMTPPDSD 796
Score = 119 bits (286), Expect = 9e-26
Identities = 134/498 (26%), Positives = 206/498 (41%), Gaps = 48/498 (9%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
Q V +TLLD NDN+P + + Y ++ + + V AVDPDLG+NG ++Y
Sbjct: 757 QKTGIATVNITLLDINDNHPTWKDAPYY-INLVEMTPPDSDVTTVVAVDPDLGENGTLVY 815
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVA------ESP---ILEGRHALFVEASDQPANPSER 548
+Q + + +N TG + E+P E + V +D P +
Sbjct: 816 SIQPPNKF-----YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTD-CGRPPLK 869
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDV 606
S A V + + N D P F P+ V + G S+ Q+ D E V
Sbjct: 870 ATSSATVFVNL---LDLNDND-PTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLV 925
Query: 607 SYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVH 665
SY + G + F + SGV+ +L R Y VA S + T+H
Sbjct: 926 SYRMPVGMPR-MDFLINSSSGVVVTTTELDRERIAKYQLRVVASDAGTPTKSSTSTLTIH 984
Query: 666 VVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTG-NVR---FLIA 721
V+DVNDE P +++V S + + F + N G N F+
Sbjct: 985 VLDVNDETPTFF-----PAVYNV---SVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG 1036
Query: 722 NQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVIS--GAGIYQVTIYIED 779
D + D + T LDRE Y M ++ + G + G V + + D
Sbjct: 1037 GNVDGKFSVGY-RDAVVRTVVGLDRETTAAY-MLILEAIDNGPVGKRHTGTATVFVTVLD 1094
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMY-TLFGEGKEMFD 838
NDN P+F ++YE + E+ G I +KATDADEG Y L G F
Sbjct: 1095 VNDNRPIFLQSSYEASVPEDIPEGHSILQ---LKATDADEGEFGRVWYRILHGNHGNNFR 1151
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVA--RDTGGLSSEAELIIMIGDENDNKPEFNQI 896
+ + G++ LDRE+ + L + A D G + S +I+ + D ND P F Q
Sbjct: 1152 IHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQ- 1210
Query: 897 EENSKVRIHRETKLNGTA 914
++ S++ + RET GT+
Sbjct: 1211 QQYSRLGL-RETAGIGTS 1227
Score = 105 bits (253), Expect = 9e-22
Identities = 118/439 (26%), Positives = 186/439 (42%), Gaps = 33/439 (7%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
S V V LLD NDN+P F NL + + G I +V A+D D G NG+V Y
Sbjct: 872 SSATVFVNLLDLNDNDPTF--QNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSY-- 927
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTI 557
R F IN ++G V E ++ L V ASD +L + +
Sbjct: 928 -RMPVGMPRMDFLINSSSGVVVTTTELDRERIAKYQLRVVASDAGTPTKSSTSTLTIHVL 986
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYE 615
+V T P F A Y V +V V + ND ++SY + G
Sbjct: 987 DVNDET-------PTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNV 1039
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQEN-ANLSIVTNATVHV--VDVNDE 672
+G F+V R V+ V L R Y A+ ATV V +DVND
Sbjct: 1040 DG-KFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDN 1098
Query: 673 RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI 732
R + L+ ++ + ++ G +I Q+ T+ G V + I + +
Sbjct: 1099 RPIFLQSSYEASV--PEDIPEGHSILQLKATDADE---GEFGRVWYRILHGNHGNNFRIH 1153
Query: 733 AEDGTIFT-QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
+G + +PLDRE+ + + ++ +N + +V +Y+ED ND PVF
Sbjct: 1154 VSNGLLMRGPRPLDRERNSSH-VLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQ 1212
Query: 792 YEGF-IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIG 850
Y + E + IGT + +++ATD D G L Y + + F++DE+TG++ +
Sbjct: 1213 YSRLGLRETAGIGTSVI---VVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITV- 1268
Query: 851 DSLDREKKIMYKLSLVARD 869
+ LD E K Y +++ A D
Sbjct: 1269 NYLDYETKTSYMMNVSATD 1287
Score = 104 bits (249), Expect = 3e-21
Identities = 91/334 (27%), Positives = 155/334 (46%), Gaps = 24/334 (7%)
Query: 71 GAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSL 128
G G NQ + +V + + D+NDN P + D PY++ + E+TP + + + P +G +
Sbjct: 752 GVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENG 811
Query: 129 TIPLTVPRGLTIFK------DIRA----FDRDKPNTPNSDVHYSIV-SGNDDGHFALESS 177
T+ ++ + IR DR+ P+ +++ IV S D G L+++
Sbjct: 812 TLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKAT 871
Query: 178 HKPVLLLRKVLDYDAGDKEFQ-LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELI 236
+ + +LD + D FQ L +A + + AID D G+ + Y +
Sbjct: 872 SSATVFVN-LLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP 930
Query: 237 SGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
G R F ++S +G + ELD + Q L+V AS P K++ + + I +
Sbjct: 931 VGMPRMDFLINSSSGVVVTTTELDRERIAKYQ-----LRVVASDAGTPTKSSTSTLTIHV 985
Query: 297 LDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSI 354
LD+ND P F YN+S+ E++P F V+ + TD D G N E +Y + + G FS+
Sbjct: 986 LDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSV 1045
Query: 355 DPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
R VR LDRE ++ + + A + P
Sbjct: 1046 GYRDA--VVRTVVGLDRETTAAYMLILEAIDNGP 1077
Score = 101 bits (243), Expect = 2e-20
Identities = 135/518 (26%), Positives = 204/518 (39%), Gaps = 65/518 (12%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN T TI EV +N + + ENI G T++ LNA DLD Y
Sbjct: 651 LNSTVPVTI-EVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSR----EYG 705
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG---N 1024
S +Y +LE F IN R G + L E SE+ L + A+DGG N
Sbjct: 706 QESIIY---------SLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHN 756
Query: 1025 LNDNI-SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYF 1083
I +V + + D+ND+ P +K Y N+ E + V A D D G+N L Y
Sbjct: 757 QKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS 816
Query: 1084 IQPSDTDLPFEISPLTG-VLSVNGELDRETEDKY------ILTVVARDNGX-XXXXXXXX 1135
IQP + + ++ TG + + + LDRE D + + V D G
Sbjct: 817 IQPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 874
Query: 1136 XXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTT 1195
D+NDN P F + E +S + ++ + + P+G
Sbjct: 875 TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMP 934
Query: 1196 VAKVFANDTDFIG------NGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEV 1249
N + + + + Y L R + G P+ SST+ L + V DV DE
Sbjct: 935 RMDFLINSSSGVVVTTTELDRERIAKYQL--RVVASDAGTPTKSSTSTLTIHVLDVNDET 992
Query: 1250 EMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV 1307
P F Y + + E+V +V LN T++ N ++ Y+I N + F
Sbjct: 993 -----PTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGN---VDGKFS 1044
Query: 1308 IDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVV 1367
+ R+ + V DRE Y +I+ A PV + T V
Sbjct: 1045 VGYRDAVVRTVVGLDRETTAAYMLILEAIDNG----------PVGKRHTGTAT-----VF 1089
Query: 1368 VRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQLK 1405
V + DVNDN P F + ++P P G+ ++QLK
Sbjct: 1090 VTVLDVNDNRPIFLQSS--YEASVPEDIPEGHSILQLK 1125
Score = 100 bits (239), Expect = 5e-20
Identities = 177/726 (24%), Positives = 285/726 (39%), Gaps = 85/726 (11%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGK-VKAVDPD--LGQNGMV-LYDLQRT 502
+ ++D NDN P F S Y ++ A+VG + ++ VD D LG N M +Y +
Sbjct: 336 ILVIDINDNAPEFNSSE-YSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNN 394
Query: 503 SNLTITSPFKINPNTGT-VSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTR 561
S+ I SP + + VA E + + P Y+ +T+
Sbjct: 395 SHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINEN 454
Query: 562 GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVP 619
+ P F Y + NV +GTSV + NDA +VSY +
Sbjct: 455 DNR------PIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR--- 505
Query: 620 FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKG 679
F++++ +G+I ++ L + +A ++ ++V+DVND K
Sbjct: 506 FSLDKDTGLIMLIARLDYELIQRFTLTIIA-RDGGGEETTGRVRINVLDVNDNVPTFQKD 564
Query: 680 AHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTD--DIAIAED-G 736
A+ + ++EN ++ Q+ + + + I + DI++ E G
Sbjct: 565 AY---VGALRENEP--SVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYG 619
Query: 737 TIFTQKPLDREK--RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEG 794
I +PLD E+ + +TV+A + G VTI + DENDNPP F Y
Sbjct: 620 VISVSRPLDYEQISNGLIYLTVMA-MDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFV 678
Query: 795 FIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLD 854
++EN G + N + E +Y+L EG F ++ +G + LD
Sbjct: 679 SVVENIMAGATVLFLNATDLDRSREYGQESIIYSL--EGSTQFRINARSGEITTTS-LLD 735
Query: 855 REKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTA 914
RE K SE LI+ D + N K I T
Sbjct: 736 RETK----------------SEYILIVRAVDGG--------VGHNQKTGI-------ATV 764
Query: 915 GFTIIEVKPKNKFALDVDQLGPLFL-IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
T++++ + D P ++ + E P + + + A+D D G NG + Y
Sbjct: 765 NITLLDINDNHPTWKDA----PYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ-- 818
Query: 974 VYIPPSKL-SADALEVKRYFVINERHGHVIVARSLPPESEF--RLNISALDGGN--LNDN 1028
PP+K S ++ K I H + P E+E ++ +S D G L
Sbjct: 819 ---PPNKFYSLNSTTGK----IRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKAT 871
Query: 1029 ISVRVFVK--DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQP 1086
S VFV D+ND+ P F+ + V E + +V A D D G N ++Y +
Sbjct: 872 SSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPV 931
Query: 1087 SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+ F I+ +GV+ ELDRE KY L VVA D G DVND
Sbjct: 932 GMPRMDFLINSSSGVVVTTTELDRERIAKYQLRVVASDAG-TPTKSSTSTLTIHVLDVND 990
Query: 1147 NSPKFY 1152
+P F+
Sbjct: 991 ETPTFF 996
Score = 95.5 bits (227), Expect = 1e-18
Identities = 131/529 (24%), Positives = 222/529 (41%), Gaps = 58/529 (10%)
Query: 440 MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
+ + V++TL++ NDN P+F LY S+ N VGT + V A D D G G V Y
Sbjct: 441 VGYAKVKITLINENDNRPIF-SQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF 499
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTI 557
+ F ++ +TG + + E R L + A D + R + V+ +
Sbjct: 500 SDDPD-----RFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDV 554
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYE 615
++P F Y + N T + ++R D+ N ++Y ++
Sbjct: 555 ---------NDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASA 605
Query: 616 EGVPFAVE--ERSGVITVVD--DLSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVDVN 670
G F + E GVI+V D + + + +A+ N L+ T+ V D N
Sbjct: 606 FGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDEN 665
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
D K A+ + V+ AGA + + T++ G ++ I + + T
Sbjct: 666 DNPPTFSKPAY--FVSVVENIMAGATVLFLNATDLDRSREYGQESI---IYSLEGSTQFR 720
Query: 731 AIAEDGTIFTQKPLDREKRDVYRMTVIA-EFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
A G I T LDRE + Y + V A + G GI V I + D NDN P ++
Sbjct: 721 INARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKD 780
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFI 849
A Y ++E + +++ + A D D G N +Y++ K + ++ TG ++
Sbjct: 781 APYYINLVEMTPPDSDV---TTVVAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTT 836
Query: 850 GDSLDREK------KIMYKLSLVARDTG----GLSSEAELIIMIGDENDNKPEFNQIEEN 899
LDRE ++M K+ + D G +S A + + + D NDN P F +
Sbjct: 837 HAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFV 896
Query: 900 SKVRIHRETKLNG-TAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIG 947
++V L G AG +I +V A+D+D+ G L+ +P+G
Sbjct: 897 AEV-------LEGIPAGVSIYQV-----VAIDLDE-GLNGLVSYRMPVG 932
Score = 95.5 bits (227), Expect = 1e-18
Identities = 116/419 (27%), Positives = 173/419 (41%), Gaps = 53/419 (12%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
E IP G +I ++ A+DLD GLNG + Y V +P + F+IN G V
Sbjct: 901 EGIPAGVSIYQVVAIDLDEGLNGLVSYRM--PVGMP-----------RMDFLINSSSGVV 947
Query: 1002 IVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ L E ++++L + A D G + ++ + V DVND P F YN +V E
Sbjct: 948 VTTTELDRERIAKYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSED 1007
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYI 1117
+ ++ TD D G NA L+YFI + D F + V+ LDRET Y+
Sbjct: 1008 VPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYM 1067
Query: 1118 LTVVARDNG-XXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESV 1176
L + A DNG DVNDN P F E PE D H S+
Sbjct: 1068 LILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIF--LQSSYEASVPE-DIPEGH---SI 1121
Query: 1177 MMIPVYKATIEENAPIGTTVAKVFAND--TDF-IGNGNGLILYS---LPQRKNQQ----- 1225
+ + KAT + G ++ + +F I NGL++ L + +N
Sbjct: 1122 LQL---KATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIV 1178
Query: 1226 ---NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYY-ELEIEENVNAPVELVSLNL 1281
N L + S+ ++V V D+ DE PVF + Y L + E ++ +
Sbjct: 1179 EAYNHDLGPMRSSVRVIVYVEDINDEA-----PVFTQQQYSRLGLRETAGIGTSVIVVQA 1233
Query: 1282 TEH--YENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
T+ + + Y IL + F ID G + V D E K +Y + V A Q
Sbjct: 1234 TDRDSGDGGLVNYRIL----SGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQ 1288
Score = 93.9 bits (223), Expect = 4e-18
Identities = 91/329 (27%), Positives = 146/329 (44%), Gaps = 23/329 (6%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIFK 142
V + + DVNDN P F + PY V + E TP G IF++ P L +V
Sbjct: 118 VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTP--IFIVNATDPDLGAGGSVLYSFQPPS 175
Query: 143 DIRAFDRDKPN-TPNSDVHYSIVSGNDDGHFALESSH-KPVLLLRK--VLDYDAGDKEFQ 198
A D + T ++ Y A + +P+ L ++ D D +
Sbjct: 176 QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPI 235
Query: 199 LVIMASGKRIHKEI---LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFL 255
+ + I++ I AIDQD G + Y ++SGN +F+LD ++G L L
Sbjct: 236 FINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTL 295
Query: 256 EKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV----EIELLDLNDNLPEFEVDFY 311
LD E+ L ++ F+L V+ ++LN+ + A V I ++D+NDN PEF Y
Sbjct: 296 NGL--LDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEY 353
Query: 312 NISIVENLPNGFSV---LQVMATDKDQGENGEF-TYQLDDPKGAFSIDPRS----GWLTV 363
+++I E GF++ +QV+ D++ G N F Y + + F I P S + +
Sbjct: 354 SVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRI 413
Query: 364 RNQTVLDREAHSSLRMKVYAKETNPSVVG 392
R LD E ++A E+ P VG
Sbjct: 414 RVAIPLDYETVDRYDFDLFANESVPDHVG 442
Score = 78.2 bits (184), Expect = 2e-13
Identities = 56/175 (32%), Positives = 88/175 (50%), Gaps = 12/175 (6%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
+ G ++ ++PLDRE + + + ++GVI+ +V I + D NDN P F + Y
Sbjct: 83 DTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITR----KVNIQVGDVNDNAPTFHNQPYS 138
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
I EN+ +GT I I+ ATD D G +Y+ F + F +D G+V I + L
Sbjct: 139 VRIPENTPVGTPI---FIVNATDPDLGAGGSVLYS-FQPPSQFFAIDSARGIVTVIRE-L 193
Query: 854 DREKKIMYKLSLVARD---TGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIH 905
D E Y+L++ A D T LS+ A L I+I D D P F + ++ + H
Sbjct: 194 DYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEH 248
Score = 74.5 bits (175), Expect = 3e-12
Identities = 84/328 (25%), Positives = 137/328 (41%), Gaps = 25/328 (7%)
Query: 77 ISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIF--LIAPIGPSLTIPLTV 134
+S ++ + I DV D PIF++ PY + E +P G I + G I T+
Sbjct: 216 LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI 275
Query: 135 PRGLTIFKDIRAFDR-----------DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLL 183
G T I A D D+ N S V G + S
Sbjct: 276 VSGNT--NSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTT 333
Query: 184 LR-KVLDYDAGDKEFQLVIMASGKRIHKEILFPEP--IHAIDQDLGVGATLRYEL-ISGN 239
V+D + EF + ++ F P I +D+D +G +E+ + GN
Sbjct: 334 FNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGN 393
Query: 240 DRKLFSLD--SVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELL 297
+ F + SV G + + + ++ + + + A++ + P A+V+I L+
Sbjct: 394 NSHHFIISPTSVQGKADIRIRVAIPLDYET-VDRYDFDLFANE-SVPDHVGYAKVKITLI 451
Query: 298 DLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPR 357
+ NDN P F YNIS+ EN+ G SVL V+ATD D G GE +Y D FS+D
Sbjct: 452 NENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKD 511
Query: 358 SGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+G + + + LD E + + A++
Sbjct: 512 TGLIMLIAR--LDYELIQRFTLTIIARD 537
Score = 73.3 bits (172), Expect = 6e-12
Identities = 84/322 (26%), Positives = 134/322 (41%), Gaps = 36/322 (11%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTD 1090
V++ + + ND+ P+F + YN ++ E + V ATD D G ++YF SD
Sbjct: 446 VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF--SDDP 503
Query: 1091 LPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
F + TG++ + LD E ++ LT++ARD G DVNDN P
Sbjct: 504 DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG---GEETTGRVRINVLDVNDNVPT 560
Query: 1151 FY--AFDELLEWKHPEADEL------------SNHNFESVMMIPVYKATIEENAPIGTTV 1196
F A+ L P +L +N S++ + + + + G V
Sbjct: 561 FQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGV 620
Query: 1197 AKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPV 1256
V + D+ NGLI ++ + G P L+ST + + V D E + P
Sbjct: 621 ISV-SRPLDYEQISNGLIYLTV----MAMDAGNPPLNSTVPVTIEVFD-----ENDNPPT 670
Query: 1257 FISRYYELEIEENVNAPVELVSLNLT--EHYENFKMRYYILN-ENDTDIRRTFVIDPRNG 1313
F Y + + EN+ A ++ LN T + + I + E T R I+ R+G
Sbjct: 671 FSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFR----INARSG 726
Query: 1314 TLYLVRSPDREVKDTYEVIVRA 1335
+ DRE K Y +IVRA
Sbjct: 727 EITTTSLLDRETKSEYILIVRA 748
Score = 73.3 bits (172), Expect = 6e-12
Identities = 87/331 (26%), Positives = 138/331 (41%), Gaps = 22/331 (6%)
Query: 73 GLNQISAYLSVTVYIE--DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLT- 129
G + A S TV++ D+NDN P F + P+ V E P G + + + L
Sbjct: 864 GRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNG 923
Query: 130 -----IPLTVPRGLTIFKDIRAFDRDKPNTPNSDV-HYSIVSGNDDGHFALESSHKPVLL 183
+P+ +PR + + Y + D +SS + +
Sbjct: 924 LVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAKYQLRVVASDAGTPTKSSTSTLTI 983
Query: 184 LRKVLDY-DAGDKEFQLVIMAS-GKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDR 241
VLD D F V S + + +E ++ D D+G+ A L Y + GN
Sbjct: 984 --HVLDVNDETPTFFPAVYNVSVSEDVPREFRVVW-LNCTDNDVGLNAELSYFITGGNVD 1040
Query: 242 KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLND 301
FS+ + + + LD E A +L+ + T A V + +LD+ND
Sbjct: 1041 GKFSVGYRDA--VVRTVVGLDRE-TTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVND 1097
Query: 302 NLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSG 359
N P F Y S+ E++P G S+LQ+ ATD D+GE G Y++ + F I +G
Sbjct: 1098 NRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNG 1157
Query: 360 WLTVRNQTVLDREAHSS--LRMKVYAKETNP 388
L +R LDRE +SS L ++ Y + P
Sbjct: 1158 -LLMRGPRPLDRERNSSHVLIVEAYNHDLGP 1187
Score = 72.1 bits (169), Expect = 1e-11
Identities = 100/405 (24%), Positives = 166/405 (40%), Gaps = 27/405 (6%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLT 506
+ +LD ND P F P+ +Y S+ + + + D D+G N + Y + +
Sbjct: 983 IHVLDVNDETPTFFPA-VYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFI---TGGN 1038
Query: 507 ITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIEVTRGTK 564
+ F + V E + L +EA D P +R++
Sbjct: 1039 VDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDN--GPVGKRHTGTATVFVTVLDVN 1096
Query: 565 GNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQN--DVSYDLLHGYEEGVPFAV 622
N+P F+ + YE V ++ G S+ Q++ DA E V Y +LHG G F +
Sbjct: 1097 DNRPI---FLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHG-NHGNNFRI 1152
Query: 623 EERSGVITVVD---DLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKG 679
+G++ D R + + EA S V V+V D+NDE V +
Sbjct: 1153 HVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSV-RVIVYVEDINDEAPVFTQQ 1211
Query: 680 AHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTI 738
+S + ++E + G ++ + T+ S G+G G V + I + + +I G I
Sbjct: 1212 QYSRL--GLRETAGIGTSVIVVQATDRDS--GDG-GLVNYRILSGAEGKFEID-ESTGLI 1265
Query: 739 FTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIME 798
T LD E + Y M V A ++ G V I + +E D F +A+YE I+E
Sbjct: 1266 ITVNYLDYETKTSYMMNVSAT-DQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILE 1324
Query: 799 NSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENT 843
N +GTEI + ++ T YT + K +F +D T
Sbjct: 1325 NLALGTEIVRVQAYSIDNLNQITYRFDAYT-STQAKALFKIDAIT 1368
Score = 69.7 bits (163), Expect = 7e-11
Identities = 61/215 (28%), Positives = 86/215 (40%), Gaps = 21/215 (9%)
Query: 939 LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERH 998
LI E+ P+G+++ +L A D+D+ P E R+F +
Sbjct: 41 LISEDTPVGSSVTQLLAQDMDND----------------PLVFGVSGEEASRFFAVEPDT 84
Query: 999 GHVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
G V + + L E SEF + S D + V + V DVND+ P F Y+ + E
Sbjct: 85 GVVWLRQPLDRETKSEFTVEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPYSVRIPE 143
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKY 1116
+ V+ATD D G ++ Y QP F I G+++V ELD ET Y
Sbjct: 144 NTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF--FAIDSARGIVTVIRELDYETTQAY 201
Query: 1117 ILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
LTV A D DV D P F
Sbjct: 202 QLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIF 236
Score = 68.9 bits (161), Expect = 1e-10
Identities = 87/327 (26%), Positives = 137/327 (41%), Gaps = 27/327 (8%)
Query: 582 VGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRP 641
+ + +G+SV Q+ D ND + G E FAVE +GV+ + L R +
Sbjct: 42 ISEDTPVGSSVTQLLAQDM--DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKS 99
Query: 642 MYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIF 701
+ E ++ ++ + I + V DVND + P + EN+ IF
Sbjct: 100 EFTVE-FSVSDHQGV-ITRKVNIQVGDVNDNAPTF---HNQPYSVRIPENTPVGT--PIF 152
Query: 702 HTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEF 760
N + G+V + Q + AI + G + + LD E Y++TV A
Sbjct: 153 IVNATDPDLGAGGSVLYSF---QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATD 209
Query: 761 NKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEG 820
+ + + I I D D P+F + Y I E+S GT ++ II A D D+G
Sbjct: 210 QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR---IITAIDQDKG 266
Query: 821 TNALFMYTLF-GEGKEMFDVDENTGVVKFIGDSLDREKKIM-YKLSLVARDT----GGLS 874
YT+ G +F +D +GV+ G LDRE + + L + T
Sbjct: 267 RPRGIGYTIVSGNTNSIFALDYISGVLTLNG-LLDRENPLYSHGFILTVKGTELNDDRTP 325
Query: 875 SEAELI----IMIGDENDNKPEFNQIE 897
S+A + I++ D NDN PEFN E
Sbjct: 326 SDATVTTTFNILVIDINDNAPEFNSSE 352
Score = 67.3 bits (157), Expect = 4e-10
Identities = 54/173 (31%), Positives = 80/173 (46%), Gaps = 8/173 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G + Y ++ GN F + NG L + LD E N ++ VL V+
Sbjct: 1124 LKATDADEGEFGRVWYRILHGNHGNNFRIHVSNG-LLMRGPRPLDRERN---SSHVLIVE 1179
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN-ISIVENLPNGFSVLQVMATDKDQG 336
A + + RV + + D+ND P F Y+ + + E G SV+ V ATD+D G
Sbjct: 1180 AYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSG 1239
Query: 337 ENGEFTYQ-LDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
+ G Y+ L +G F ID +G + N LD E +S M V A + P
Sbjct: 1240 DGGLVNYRILSGAEGKFEIDESTGLIITVN--YLDYETKTSYMMNVSATDQAP 1290
Score = 63.7 bits (148), Expect = 5e-09
Identities = 59/211 (27%), Positives = 92/211 (43%), Gaps = 31/211 (14%)
Query: 929 LDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEF-------NSEV 974
LDV+ P+FL +PE+IP G +I++L A D D G G++ Y N +
Sbjct: 1093 LDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRI 1152
Query: 975 YIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVF 1034
++ L + R HV++ + D G + ++ V V+
Sbjct: 1153 HVSNGLLMRGPRPLDR----ERNSSHVLIVEAYNH-----------DLGPMRSSVRVIVY 1197
Query: 1035 VKDVNDHFPVFKKTWYN-FNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPF 1093
V+D+ND PVF + Y+ + E + V ATD D G + Y I S + F
Sbjct: 1198 VEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRIL-SGAEGKF 1256
Query: 1094 EISPLTGVLSVNGELDRETEDKYILTVVARD 1124
EI TG++ LD ET+ Y++ V A D
Sbjct: 1257 EIDESTGLIITVNYLDYETKTSYMMNVSATD 1287
Score = 62.9 bits (146), Expect = 9e-09
Identities = 53/170 (31%), Positives = 77/170 (45%), Gaps = 8/170 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGND-RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D+D + Y ++S + F + G + LD E + L V
Sbjct: 583 LRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ-ISNGLIYLTV 641
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A NP + V IE+ D NDN P F Y +S+VEN+ G +VL + ATD D+
Sbjct: 642 MAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRS 701
Query: 337 -ENGE--FTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
E G+ Y L+ F I+ RSG +T ++LDRE S + V A
Sbjct: 702 REYGQESIIYSLEG-STQFRINARSGEIT--TTSLLDRETKSEYILIVRA 748
Score = 62.5 bits (145), Expect = 1e-08
Identities = 57/225 (25%), Positives = 96/225 (42%), Gaps = 15/225 (6%)
Query: 236 ISGNDR-KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
+SG + + F+++ G ++L + LD + + + F ++ S + +V I
Sbjct: 69 VSGEEASRFFAVEPDTGVVWLRQPLDRETK-----SEFTVEFSVSDHQGVITR---KVNI 120
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
++ D+NDN P F Y++ I EN P G + V ATD D G G Y P F+I
Sbjct: 121 QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180
Query: 355 DPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPS-VVGTFADSQRIAK--WRRQPLETN 411
D G +TV + LD E + ++ V A + + + + T A+ I P+ N
Sbjct: 181 DSARGIVTVIRE--LDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFIN 238
Query: 412 APLEKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNN 456
P Y GT I D+ + T++ N N+
Sbjct: 239 LPYSTNIYEH-SPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNS 282
Score = 58.4 bits (135), Expect = 2e-07
Identities = 41/126 (32%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D G + Y DR FSLD G + L LD + F L + A
Sbjct: 484 ATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYEL-----IQRFTLTIIAR 536
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
T RV I +LD+NDN+P F+ D Y ++ EN P+ ++++ ATD+D N
Sbjct: 537 DGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNN 594
Query: 340 EFTYQL 345
+ TY +
Sbjct: 595 QITYSI 600
Score = 52.4 bits (120), Expect = 1e-05
Identities = 45/182 (24%), Positives = 78/182 (42%), Gaps = 16/182 (8%)
Query: 432 IEYYDEQL---MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPD 488
+E Y+ L S V V V + D ND PVF ++ A +GT + V+A D D
Sbjct: 1178 VEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRD 1237
Query: 489 LGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPS 546
G G+V Y + + F+I+ +TG + E + + + V A+DQ A P
Sbjct: 1238 SGDGGLVNYRILSGAE----GKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQ-APPF 1292
Query: 547 ERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDV 606
+ + +T+ + F A YE + N+ +GT + +++ N +
Sbjct: 1293 NQGFCSVYITL------LNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQI 1346
Query: 607 SY 608
+Y
Sbjct: 1347 TY 1348
Score = 44.8 bits (101), Expect = 0.002
Identities = 44/152 (28%), Positives = 72/152 (47%), Gaps = 28/152 (18%)
Query: 1233 SSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN--FKM 1290
+ TA + VTV DV D ++P+F+ YE + E++ ++ L T+ E ++
Sbjct: 1083 TGTATVFVTVLDVND-----NRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRV 1137
Query: 1291 RYYILNENDTDIRRTFVIDPRNGTLYLVRSP-DREVKDTYEVIVRAERQKYSRELPHMIY 1349
Y IL+ N + F I NG L P DRE ++ +IV A Y+ +L
Sbjct: 1138 WYRILHGNHGN---NFRIHVSNGLLMRGPRPLDRERNSSHVLIVEA----YNHDL----- 1185
Query: 1350 PVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
G + V+V+V ++D+ND +P FT
Sbjct: 1186 --------GPMRSSVRVIVYVEDINDEAPVFT 1209
Score = 33.5 bits (73), Expect = 6.0
Identities = 16/45 (35%), Positives = 25/45 (55%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTP 111
+V AG S+ ++T+++ DVND P F Y+V+V E P
Sbjct: 965 VVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVP 1009
>BC032581-1|AAH32581.1| 1061|Homo sapiens CDH23 protein protein.
Length = 1061
Score = 143 bits (346), Expect = 5e-33
Identities = 215/799 (26%), Positives = 316/799 (39%), Gaps = 125/799 (15%)
Query: 403 WRRQPLETNAPLEKTT-YVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVP 461
W RQPL+ E T + D G T VN++V D NDN P F
Sbjct: 88 WLRQPLDRETKSEFTVEFSVSDHQGVITRK-----------VNIQVG--DVNDNAPTF-H 133
Query: 462 SNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVS 521
+ Y + N VGT I V A DPDLG G VLY Q S F I+ G V+
Sbjct: 134 NQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF-----FAIDSARGIVT 188
Query: 522 VAESPILEGRHA--LFVEASDQP-ANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPY 578
V E A L V A+DQ P +LA++ +V + P F+ PY
Sbjct: 189 VIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV-------QDMDPIFINLPY 241
Query: 579 EFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLS 636
+ + GT+V I D + Y ++ G + FA++ SGV+T+ L
Sbjct: 242 STNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSI-FALDYISGVLTLNGLLD 300
Query: 637 RYNRPMYDFEAVALQENANLS---------IVTNATVHVVDVNDERGVLLKGAHSPIIFH 687
R N P+Y + + L+ + T + V+D+ND +S I
Sbjct: 301 REN-PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITE 359
Query: 688 VKENSAGAAIG-QIFH-------TNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIF 739
+ + + Q+ +M +Y G + F+I+ + D I
Sbjct: 360 LAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIIS-----PTSVQGKADIRIR 414
Query: 740 TQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMEN 799
PLD E D Y + A N+ V G +V I + +ENDN P+F Y + EN
Sbjct: 415 VAIPLDYETVDRYDFDLFA--NESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYEN 472
Query: 800 SKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKI 859
+GT + + ATD D GT FGE V F D DR
Sbjct: 473 VTVGTSVLT---VLATDNDAGT--------FGE------------VSYFFSDDPDR---- 505
Query: 860 MYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTII 919
+ L +DTG LI++I + ++ I+ + I R+ T G I
Sbjct: 506 -FSLD---KDTG-------LIMLIA-----RLDYELIQRFTLTIIARDGGGEETTGRVRI 549
Query: 920 EVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPS 979
V N + + + EN P T +++L A D DS N QI Y S
Sbjct: 550 NVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITY----------S 599
Query: 980 KLSADALEVKRYFVINERHGHVIVARSLPPESE------FRLNISALDGGN--LNDNISV 1031
+SA A YF I+ G+ +++ S P + E L + A+D GN LN + V
Sbjct: 600 IVSASAFG--SYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPV 657
Query: 1032 RVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDL 1091
+ V D ND+ P F K Y +V E + ++ATD D + I +
Sbjct: 658 TIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST 717
Query: 1092 PFEISPLTGVLSVNGELDRETEDKYILTVVARDNG-XXXXXXXXXXXXXXXXDVNDNSPK 1150
F I+ +G ++ LDRET+ +YIL V A D G D+NDN P
Sbjct: 718 QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
Query: 1151 FY---AFDELLEWKHPEAD 1166
+ + L+E P++D
Sbjct: 778 WKDAPYYINLVEMTPPDSD 796
Score = 98.7 bits (235), Expect = 1e-19
Identities = 176/726 (24%), Positives = 285/726 (39%), Gaps = 85/726 (11%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGK-VKAVDPD--LGQNGMV-LYDLQRT 502
+ ++D NDN P F S Y ++ A+VG + ++ VD D LG N M +Y +
Sbjct: 336 ILVIDINDNAPEFNSSE-YSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNN 394
Query: 503 SNLTITSPFKINPNTGT-VSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTR 561
S+ I SP + + VA E + + P Y+ +T+
Sbjct: 395 SHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINEN 454
Query: 562 GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVP 619
+ P F Y + NV +GTSV + NDA +VSY +
Sbjct: 455 DNR------PIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR--- 505
Query: 620 FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKG 679
F++++ +G+I ++ L + +A ++ ++V+DVND K
Sbjct: 506 FSLDKDTGLIMLIARLDYELIQRFTLTIIA-RDGGGEETTGRVRINVLDVNDNVPTFQKD 564
Query: 680 AHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTD--DIAIAED-G 736
A+ + ++EN ++ Q+ + + + I + DI++ E G
Sbjct: 565 AY---VGALRENEP--SVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYG 619
Query: 737 TIFTQKPLDREK--RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEG 794
I +PLD E+ + +TV+A + G VTI + DENDNPP F Y
Sbjct: 620 VISVSRPLDYEQISNGLIYLTVMA-MDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFV 678
Query: 795 FIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLD 854
++EN G + N + E +Y+L EG F ++ +G + LD
Sbjct: 679 SVVENIMAGATVLFLNATDLDRSREYGQESIIYSL--EGSTQFRINARSGEITTTS-LLD 735
Query: 855 REKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTA 914
RE K SE LI+ D + N K I T
Sbjct: 736 RETK----------------SEYILIVRAVDGG--------VGHNQKTGI-------ATV 764
Query: 915 GFTIIEVKPKNKFALDVDQLGPLFL-IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
T++++ + D P ++ + E P + + + A+D D G NG + Y
Sbjct: 765 NITLLDINDNHPTWKDA----PYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ-- 818
Query: 974 VYIPPSKL-SADALEVKRYFVINERHGHVIVARSLPPESEF--RLNISALDGGN--LNDN 1028
PP+K S ++ K I H + P E+E ++ +S D G L
Sbjct: 819 ---PPNKFYSLNSTTGK----IRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKAT 871
Query: 1029 ISVRVFVK--DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQP 1086
S VFV D+ND+ P F+ + V E + +V A D D G N ++Y +
Sbjct: 872 SSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPV 931
Query: 1087 SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+ F I+ +GV+ ELDRE +Y L VVA D G DVND
Sbjct: 932 GMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAG-TPTKSSTSTLTIHVLDVND 990
Query: 1147 NSPKFY 1152
+P F+
Sbjct: 991 ETPTFF 996
Score = 96.7 bits (230), Expect = 6e-19
Identities = 79/287 (27%), Positives = 135/287 (47%), Gaps = 20/287 (6%)
Query: 71 GAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSL 128
G G NQ + +V + + D+NDN P + D PY++ + E+TP + + + P +G +
Sbjct: 752 GVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENG 811
Query: 129 TIPLTVPRGLTIFK------DIRA----FDRDKPNTPNSDVHYSIV-SGNDDGHFALESS 177
T+ ++ + IR DR+ P+ +++ IV S D G L+++
Sbjct: 812 TLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKAT 871
Query: 178 HKPVLLLRKVLDYDAGDKEFQ-LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELI 236
+ + +LD + D FQ L +A + + AID D G+ + Y +
Sbjct: 872 SSATVFVN-LLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP 930
Query: 237 SGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
G R F ++S +G + ELD + Q L+V AS P K++ + + I +
Sbjct: 931 VGMPRMDFLINSSSGVVVTTTELDRERIAEYQ-----LRVVASDAGTPTKSSTSTLTIHV 985
Query: 297 LDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTY 343
LD+ND P F YN+S+ E++P F V+ + TD D G N E +Y
Sbjct: 986 LDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSY 1032
Score = 95.5 bits (227), Expect = 1e-18
Identities = 131/529 (24%), Positives = 222/529 (41%), Gaps = 58/529 (10%)
Query: 440 MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
+ + V++TL++ NDN P+F LY S+ N VGT + V A D D G G V Y
Sbjct: 441 VGYAKVKITLINENDNRPIF-SQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF 499
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTI 557
+ F ++ +TG + + E R L + A D + R + V+ +
Sbjct: 500 SDDPD-----RFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDV 554
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYE 615
++P F Y + N T + ++R D+ N ++Y ++
Sbjct: 555 ---------NDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASA 605
Query: 616 EGVPFAVE--ERSGVITVVD--DLSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVDVN 670
G F + E GVI+V D + + + +A+ N L+ T+ V D N
Sbjct: 606 FGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDEN 665
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
D K A+ + V+ AGA + + T++ G ++ I + + T
Sbjct: 666 DNPPTFSKPAY--FVSVVENIMAGATVLFLNATDLDRSREYGQESI---IYSLEGSTQFR 720
Query: 731 AIAEDGTIFTQKPLDREKRDVYRMTVIA-EFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
A G I T LDRE + Y + V A + G GI V I + D NDN P ++
Sbjct: 721 INARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKD 780
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFI 849
A Y ++E + +++ + A D D G N +Y++ K + ++ TG ++
Sbjct: 781 APYYINLVEMTPPDSDV---TTVVAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTT 836
Query: 850 GDSLDREK------KIMYKLSLVARDTG----GLSSEAELIIMIGDENDNKPEFNQIEEN 899
LDRE ++M K+ + D G +S A + + + D NDN P F +
Sbjct: 837 HAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFV 896
Query: 900 SKVRIHRETKLNG-TAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIG 947
++V L G AG +I +V A+D+D+ G L+ +P+G
Sbjct: 897 AEV-------LEGIPAGVSIYQV-----VAIDLDE-GLNGLVSYRMPVG 932
Score = 93.9 bits (223), Expect = 4e-18
Identities = 91/329 (27%), Positives = 146/329 (44%), Gaps = 23/329 (6%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIFK 142
V + + DVNDN P F + PY V + E TP G IF++ P L +V
Sbjct: 118 VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTP--IFIVNATDPDLGAGGSVLYSFQPPS 175
Query: 143 DIRAFDRDKPN-TPNSDVHYSIVSGNDDGHFALESSH-KPVLLLRK--VLDYDAGDKEFQ 198
A D + T ++ Y A + +P+ L ++ D D +
Sbjct: 176 QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPI 235
Query: 199 LVIMASGKRIHKEI---LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFL 255
+ + I++ I AIDQD G + Y ++SGN +F+LD ++G L L
Sbjct: 236 FINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTL 295
Query: 256 EKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV----EIELLDLNDNLPEFEVDFY 311
LD E+ L ++ F+L V+ ++LN+ + A V I ++D+NDN PEF Y
Sbjct: 296 NGL--LDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEY 353
Query: 312 NISIVENLPNGFSV---LQVMATDKDQGENGEF-TYQLDDPKGAFSIDPRS----GWLTV 363
+++I E GF++ +QV+ D++ G N F Y + + F I P S + +
Sbjct: 354 SVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRI 413
Query: 364 RNQTVLDREAHSSLRMKVYAKETNPSVVG 392
R LD E ++A E+ P VG
Sbjct: 414 RVAIPLDYETVDRYDFDLFANESVPDHVG 442
Score = 86.6 bits (205), Expect = 6e-16
Identities = 107/407 (26%), Positives = 162/407 (39%), Gaps = 45/407 (11%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN T TI EV +N + + ENI G T++ LNA DLD Y
Sbjct: 651 LNSTVPVTI-EVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSR----EYG 705
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG---N 1024
S +Y +LE F IN R G + L E SE+ L + A+DGG N
Sbjct: 706 QESIIY---------SLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHN 756
Query: 1025 LNDNI-SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYF 1083
I +V + + D+ND+ P +K Y N+ E + V A D D G+N L Y
Sbjct: 757 QKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS 816
Query: 1084 IQPSDTDLPFEISPLTG-VLSVNGELDRETEDKY------ILTVVARDNGX-XXXXXXXX 1135
IQP + + ++ TG + + + LDRE D + + V D G
Sbjct: 817 IQPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 874
Query: 1136 XXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTT 1195
D+NDN P F + E +S + ++ + + P+G
Sbjct: 875 TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMP 934
Query: 1196 VAKVFANDTDFIG------NGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEV 1249
N + + + + Y L R + G P+ SST+ L + V DV DE
Sbjct: 935 RMDFLINSSSGVVVTTTELDRERIAEYQL--RVVASDAGTPTKSSTSTLTIHVLDVNDET 992
Query: 1250 EMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYI 1294
P F Y + + E+V +V LN T++ N ++ Y+I
Sbjct: 993 -----PTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFI 1034
Score = 78.2 bits (184), Expect = 2e-13
Identities = 56/175 (32%), Positives = 88/175 (50%), Gaps = 12/175 (6%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
+ G ++ ++PLDRE + + + ++GVI+ +V I + D NDN P F + Y
Sbjct: 83 DTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITR----KVNIQVGDVNDNAPTFHNQPYS 138
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
I EN+ +GT I I+ ATD D G +Y+ F + F +D G+V I + L
Sbjct: 139 VRIPENTPVGTPI---FIVNATDPDLGAGGSVLYS-FQPPSQFFAIDSARGIVTVIRE-L 193
Query: 854 DREKKIMYKLSLVARD---TGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIH 905
D E Y+L++ A D T LS+ A L I+I D D P F + ++ + H
Sbjct: 194 DYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEH 248
Score = 76.6 bits (180), Expect = 6e-13
Identities = 60/174 (34%), Positives = 88/174 (50%), Gaps = 14/174 (8%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSL-----FLEKELDLDAEHNLQANTFVL 274
A+D DLG TL Y + N K +SL+S G + L++E E L V
Sbjct: 802 AVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVS 859
Query: 275 QVQASQLNNPLK-TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
+ PLK T+ A V + LLDLNDN P F+ + ++E +P G S+ QV+A D
Sbjct: 860 VTDCGR--PPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDL 917
Query: 334 DQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D+G NG +Y++ P+ F I+ SG V T LDRE + +++V A +
Sbjct: 918 DEGLNGLVSYRMPVGMPRMDFLINSSSG--VVVTTTELDRERIAEYQLRVVASD 969
Score = 74.5 bits (175), Expect = 3e-12
Identities = 84/328 (25%), Positives = 137/328 (41%), Gaps = 25/328 (7%)
Query: 77 ISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIF--LIAPIGPSLTIPLTV 134
+S ++ + I DV D PIF++ PY + E +P G I + G I T+
Sbjct: 216 LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI 275
Query: 135 PRGLTIFKDIRAFDR-----------DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLL 183
G T I A D D+ N S V G + S
Sbjct: 276 VSGNT--NSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTT 333
Query: 184 LR-KVLDYDAGDKEFQLVIMASGKRIHKEILFPEP--IHAIDQDLGVGATLRYEL-ISGN 239
V+D + EF + ++ F P I +D+D +G +E+ + GN
Sbjct: 334 FNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGN 393
Query: 240 DRKLFSLD--SVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELL 297
+ F + SV G + + + ++ + + + A++ + P A+V+I L+
Sbjct: 394 NSHHFIISPTSVQGKADIRIRVAIPLDYET-VDRYDFDLFANE-SVPDHVGYAKVKITLI 451
Query: 298 DLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPR 357
+ NDN P F YNIS+ EN+ G SVL V+ATD D G GE +Y D FS+D
Sbjct: 452 NENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKD 511
Query: 358 SGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+G + + + LD E + + A++
Sbjct: 512 TGLIMLIAR--LDYELIQRFTLTIIARD 537
Score = 73.3 bits (172), Expect = 6e-12
Identities = 84/322 (26%), Positives = 134/322 (41%), Gaps = 36/322 (11%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTD 1090
V++ + + ND+ P+F + YN ++ E + V ATD D G ++YF SD
Sbjct: 446 VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF--SDDP 503
Query: 1091 LPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
F + TG++ + LD E ++ LT++ARD G DVNDN P
Sbjct: 504 DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG---GEETTGRVRINVLDVNDNVPT 560
Query: 1151 FY--AFDELLEWKHPEADEL------------SNHNFESVMMIPVYKATIEENAPIGTTV 1196
F A+ L P +L +N S++ + + + + G V
Sbjct: 561 FQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGV 620
Query: 1197 AKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPV 1256
V + D+ NGLI ++ + G P L+ST + + V D E + P
Sbjct: 621 ISV-SRPLDYEQISNGLIYLTV----MAMDAGNPPLNSTVPVTIEVFD-----ENDNPPT 670
Query: 1257 FISRYYELEIEENVNAPVELVSLNLT--EHYENFKMRYYILN-ENDTDIRRTFVIDPRNG 1313
F Y + + EN+ A ++ LN T + + I + E T R I+ R+G
Sbjct: 671 FSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFR----INARSG 726
Query: 1314 TLYLVRSPDREVKDTYEVIVRA 1335
+ DRE K Y +IVRA
Sbjct: 727 EITTTSLLDRETKSEYILIVRA 748
Score = 69.7 bits (163), Expect = 7e-11
Identities = 61/215 (28%), Positives = 86/215 (40%), Gaps = 21/215 (9%)
Query: 939 LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERH 998
LI E+ P+G+++ +L A D+D+ P E R+F +
Sbjct: 41 LISEDTPVGSSVTQLLAQDMDND----------------PLVFGVSGEEASRFFAVEPDT 84
Query: 999 GHVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
G V + + L E SEF + S D + V + V DVND+ P F Y+ + E
Sbjct: 85 GVVWLRQPLDRETKSEFTVEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPYSVRIPE 143
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKY 1116
+ V+ATD D G ++ Y QP F I G+++V ELD ET Y
Sbjct: 144 NTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF--FAIDSARGIVTVIRELDYETTQAY 201
Query: 1117 ILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
LTV A D DV D P F
Sbjct: 202 QLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIF 236
Score = 68.9 bits (161), Expect = 1e-10
Identities = 87/327 (26%), Positives = 137/327 (41%), Gaps = 27/327 (8%)
Query: 582 VGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRP 641
+ + +G+SV Q+ D ND + G E FAVE +GV+ + L R +
Sbjct: 42 ISEDTPVGSSVTQLLAQDM--DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKS 99
Query: 642 MYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIF 701
+ E ++ ++ + I + V DVND + P + EN+ IF
Sbjct: 100 EFTVE-FSVSDHQGV-ITRKVNIQVGDVNDNAPTF---HNQPYSVRIPENTPVGT--PIF 152
Query: 702 HTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEF 760
N + G+V + Q + AI + G + + LD E Y++TV A
Sbjct: 153 IVNATDPDLGAGGSVLYSF---QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATD 209
Query: 761 NKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEG 820
+ + + I I D D P+F + Y I E+S GT ++ II A D D+G
Sbjct: 210 QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR---IITAIDQDKG 266
Query: 821 TNALFMYTLF-GEGKEMFDVDENTGVVKFIGDSLDREKKIM-YKLSLVARDT----GGLS 874
YT+ G +F +D +GV+ G LDRE + + L + T
Sbjct: 267 RPRGIGYTIVSGNTNSIFALDYISGVLTLNG-LLDRENPLYSHGFILTVKGTELNDDRTP 325
Query: 875 SEAELI----IMIGDENDNKPEFNQIE 897
S+A + I++ D NDN PEFN E
Sbjct: 326 SDATVTTTFNILVIDINDNAPEFNSSE 352
Score = 68.9 bits (161), Expect = 1e-10
Identities = 68/247 (27%), Positives = 102/247 (41%), Gaps = 24/247 (9%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
Q V +TLLD NDN+P + + Y ++ + + V AVDPDLG+NG ++Y
Sbjct: 757 QKTGIATVNITLLDINDNHPTWKDAPYY-INLVEMTPPDSDVTTVVAVDPDLGENGTLVY 815
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVA------ESP---ILEGRHALFVEASDQPANPSER 548
+Q + + +N TG + E+P E + V +D P +
Sbjct: 816 SIQPPNKF-----YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTD-CGRPPLK 869
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDV 606
S A V + + N D P F P+ V + G S+ Q+ D E V
Sbjct: 870 ATSSATVFVNL---LDLNDND-PTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLV 925
Query: 607 SYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVH 665
SY + G + F + SGV+ +L R Y VA S + T+H
Sbjct: 926 SYRMPVGMPR-MDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIH 984
Query: 666 VVDVNDE 672
V+DVNDE
Sbjct: 985 VLDVNDE 991
Score = 62.9 bits (146), Expect = 9e-09
Identities = 53/170 (31%), Positives = 77/170 (45%), Gaps = 8/170 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGND-RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D+D + Y ++S + F + G + LD E + L V
Sbjct: 583 LRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ-ISNGLIYLTV 641
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A NP + V IE+ D NDN P F Y +S+VEN+ G +VL + ATD D+
Sbjct: 642 MAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRS 701
Query: 337 -ENGE--FTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
E G+ Y L+ F I+ RSG +T ++LDRE S + V A
Sbjct: 702 REYGQESIIYSLEG-STQFRINARSGEIT--TTSLLDRETKSEYILIVRA 748
Score = 62.5 bits (145), Expect = 1e-08
Identities = 57/225 (25%), Positives = 96/225 (42%), Gaps = 15/225 (6%)
Query: 236 ISGNDR-KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
+SG + + F+++ G ++L + LD + + + F ++ S + +V I
Sbjct: 69 VSGEEASRFFAVEPDTGVVWLRQPLDRETK-----SEFTVEFSVSDHQGVITR---KVNI 120
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
++ D+NDN P F Y++ I EN P G + V ATD D G G Y P F+I
Sbjct: 121 QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180
Query: 355 DPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPS-VVGTFADSQRIAK--WRRQPLETN 411
D G +TV + LD E + ++ V A + + + + T A+ I P+ N
Sbjct: 181 DSARGIVTVIRE--LDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFIN 238
Query: 412 APLEKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNN 456
P Y GT I D+ + T++ N N+
Sbjct: 239 LPYSTNIYEH-SPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNS 282
Score = 62.1 bits (144), Expect = 1e-08
Identities = 72/264 (27%), Positives = 121/264 (45%), Gaps = 38/264 (14%)
Query: 144 IRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKP--VLLLRKVLDYDA-GDKEFQLV 200
+RA D D P PN+ + YSIVS + G + S ++ V+ + + LDY+ + L
Sbjct: 583 LRATDEDSP--PNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLT 640
Query: 201 IMA---------SGKRIHKEIL--------FPEPIHAID--QDLGVGATLRYELISGNDR 241
+MA S + E+ F +P + + +++ GAT+ + + DR
Sbjct: 641 VMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDR 700
Query: 242 -KLFSLDSVNGSLFLEKELDLDAEHNLQANT----------FVLQVQASQ--LNNPLKTA 288
+ + +S+ SL + ++A T ++L V+A + + KT
Sbjct: 701 SREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTG 760
Query: 289 QARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDP 348
A V I LLD+NDN P ++ Y I++VE P V V+A D D GENG Y + P
Sbjct: 761 IATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP 820
Query: 349 KGAFSIDPRSGWLTVRNQTVLDRE 372
+S++ +G + +LDRE
Sbjct: 821 NKFYSLNSTTGKIRT-THAMLDRE 843
Score = 58.4 bits (135), Expect = 2e-07
Identities = 41/126 (32%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D G + Y DR FSLD G + L LD + F L + A
Sbjct: 484 ATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYEL-----IQRFTLTIIAR 536
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
T RV I +LD+NDN+P F+ D Y ++ EN P+ ++++ ATD+D N
Sbjct: 537 DGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNN 594
Query: 340 EFTYQL 345
+ TY +
Sbjct: 595 QITYSI 600
Score = 52.8 bits (121), Expect = 9e-06
Identities = 99/413 (23%), Positives = 170/413 (41%), Gaps = 47/413 (11%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPD----LGQNGM 494
L S V V + + D NDN P F Y S+ N G + + A D D GQ
Sbjct: 651 LNSTVPVTIEVFDENDNPPTF-SKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQES- 708
Query: 495 VLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSL 552
++Y L+ ++ F+IN +G ++ E + + L V A D +++
Sbjct: 709 IIYSLEGSTQ------FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKT--- 759
Query: 553 AVVTIEVTR-GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQI-RVNDAFEQNDVSYDL 610
+ T+ +T N P D APY + + V + V+ +N L
Sbjct: 760 GIATVNITLLDINDNHPTWKD---APYYINLVEMTPPDSDVTTVVAVDPDLGENGT---L 813
Query: 611 LHGYEEGVPF-AVEERSGVI-TVVDDLSRYNRPMYDFE-----AVALQENAN--LSIVTN 661
++ + F ++ +G I T L R N ++ E V++ + L ++
Sbjct: 814 VYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSS 873
Query: 662 ATVHV--VDVNDERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRF 718
ATV V +D+ND + P + V E AG +I Q+ ++ NG + R
Sbjct: 874 ATVFVNLLDLNDNDPTF---QNLPFVAEVLEGIPAGVSIYQVVAIDLDEGL-NGLVSYRM 929
Query: 719 LIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIE 778
+ + D + + G + T LDRE+ Y++ V+A + G + + +TI++
Sbjct: 930 PVGMPR--MDFLINSSSGVVVTTTELDRERIAEYQLRVVAS-DAGTPTKSSTSTLTIHVL 986
Query: 779 DENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG 831
D ND P F A Y + E+ + E ++ + TD D G NA Y + G
Sbjct: 987 DVNDETPTFFPAVYNVSVSED--VPREFRV-VWLNCTDNDVGLNAELSYFITG 1036
Score = 44.0 bits (99), Expect = 0.004
Identities = 60/250 (24%), Positives = 103/250 (41%), Gaps = 36/250 (14%)
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTDFIGN-GNGLILYSLP-QRKNQQNLGLPSLSSTAI 1237
P Y ++ EN G TV + A D D G I+YSL + + N +++T++
Sbjct: 674 PAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSL 733
Query: 1238 LMVTVADVPDEVEMSDKPVFISRYYELEIEENVN---APVELVSLNLTEHYENFK-MRYY 1293
L + E + + I R + + N A V + L++ +++ +K YY
Sbjct: 734 L---------DRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYY 784
Query: 1294 I----LNENDTDIRRTFVIDP---RNGTL-YLVRSPDR---------EVKDTYEVIVRAE 1336
I + D+D+ +DP NGTL Y ++ P++ +++ T+ ++ R
Sbjct: 785 INLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDREN 844
Query: 1337 RQKYSRELPHMIYPVAEDVLEGMTKY--DVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTT 1394
+ EL I D K V V + D+NDN P F N P V +
Sbjct: 845 PDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ--NLPFVAEVLEG 902
Query: 1395 APFGYQVMQL 1404
P G + Q+
Sbjct: 903 IPAGVSIYQV 912
Score = 33.5 bits (73), Expect = 6.0
Identities = 16/45 (35%), Positives = 25/45 (55%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTP 111
+V AG S+ ++T+++ DVND P F Y+V+V E P
Sbjct: 965 VVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVP 1009
>BX537422-1|CAD97664.1| 1203|Homo sapiens hypothetical protein
protein.
Length = 1203
Score = 142 bits (345), Expect = 7e-33
Identities = 167/629 (26%), Positives = 276/629 (43%), Gaps = 82/629 (13%)
Query: 738 IFTQKPLDREKRDVYRMTV-IAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFI 796
+ Q+ LDRE++D Y M + + + S I QVT+ D NDN PVF+ E I
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV--SDVNDNRPVFKEGQVEVHI 261
Query: 797 MENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG-----KEMFDVDENTGVVKFIGD 851
EN+ +GT + + ATDAD G+NA Y +FG K +F ++ TG++ +
Sbjct: 262 PENAPVGTSVIQ---LHATDADIGSNAEIRY-IFGAQVAPATKRLFALNNTTGLIT-VQR 316
Query: 852 SLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
SLDRE+ ++K++++A D G S+ A + I N + N N +R + + +N
Sbjct: 317 SLDREETAIHKVTVLASD--GSSTPARATVTI-----NVTDVNDNPPNIDLR-YIISPIN 368
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
GT + E P+ T I + D D+ +NG++
Sbjct: 369 GTV------------------------YLSEKDPVNTKIALITVSDKDTDVNGKVICFIE 404
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGG--NLNDNI 1029
EV P L A + +Y + EF I A D G +LN
Sbjct: 405 REV---PFHLKA--VYDNQYLLETSS------LLDYEGTKEFSFKIVASDSGKPSLNQTA 453
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
VRV ++D ND+ P+F + +V E L + ATD D G+NA++ Y + P+ +
Sbjct: 454 LVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS 513
Query: 1090 DLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
F++ TGVL+ + DRE ++++I TV ARDNG D NDNSP
Sbjct: 514 F--FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVL-DENDNSP 570
Query: 1150 KFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGN 1209
KF ++ ++ L ++ +V +I V A EN + T++ + ND +
Sbjct: 571 KFTHN----HFQFFVSENLPKYS--TVGVITVTDADAGENKAV--TLSILNDNDNFVLDP 622
Query: 1210 GNGLILYSLPQRKNQQNL----------GLPSLSSTAILMVTVADVPDEVEMSDKPVFIS 1259
+G+I ++ + QQ+ G P SSTA + + V DV D + P +
Sbjct: 623 YSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNT 682
Query: 1260 RYYELEIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVR 1319
+ + + + V V + N +++Y I++ N+ + F IDP G + L
Sbjct: 683 SFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGL---FRIDPVTGNITLEE 739
Query: 1320 SPDREVKDTYEVIVRAERQKYSRELPHMI 1348
P + ++V Y + L ++
Sbjct: 740 KPAPTDVGLHRLVVNISDLGYPKSLHTLV 768
Score = 125 bits (301), Expect = 1e-27
Identities = 176/674 (26%), Positives = 278/674 (41%), Gaps = 60/674 (8%)
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGF-SVLQVMATDKD 334
V+ S + T R++ E L + E F+ + +V LPN F ++++ KD
Sbjct: 76 VKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVI-LPNDFFRLIKIKIIVKD 134
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLR-MKVYAKETNPSVVGT 393
+N P SI P + + R + + ++ Y SV G
Sbjct: 135 TNDNAPM---FPSPVINISI-PENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGL 190
Query: 394 -FADSQRIAKWRRQPLETNAPLE-KTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLD 451
++ KW + ++ N E K TYV KV + Q S ++VT+ D
Sbjct: 191 DIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVE------DGGTPQKSSTAILQVTVSD 244
Query: 452 ANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPF 511
NDN PVF + E + NA VGT + ++ A D D+G N + Y F
Sbjct: 245 VNDNRPVFKEGQV-EVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLF 303
Query: 512 KINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPD 569
+N TG ++V S E H + V ASD + P+ A VTI VT N P+
Sbjct: 304 ALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPAR-----ATVTINVT-DVNDNPPN 357
Query: 570 IP-DFMGAPYE--FWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF---AVE 623
I ++ +P ++ + T + I V+D + DV+ ++ E VPF AV
Sbjct: 358 IDLRYIISPINGTVYLSEKDPVNTKIALITVSD--KDTDVNGKVICFIEREVPFHLKAVY 415
Query: 624 ERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLLKGAHS 682
+ ++ L + F+ VA +L+ V + D ND + +
Sbjct: 416 DNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF----NQ 471
Query: 683 PII-FHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
P+I V EN+ G + I T+ S G V L N D + G +
Sbjct: 472 PVIELSVSENNRRGLYLTTISATDEDS--GKNADIVYQLGPNASFFDLD---RKTGVLTA 526
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
+ DRE+++ + TV A N G V + + DENDN P F H ++ F+ EN
Sbjct: 527 SRVFDREEQERFIFTVTARDN-GTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL 585
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIM 860
+ + +I TDAD G N ++ + + F +D +GV+K S DRE++
Sbjct: 586 PKYSTV---GVITVTDADAGENKAVTLSILND-NDNFVLDPYSGVIK-SNVSFDREQQSS 640
Query: 861 YKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTI 918
Y + A D G SS A++ I + D NDN P N+ ++ L+ G +
Sbjct: 641 YTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKL---VPLSAIPGSVV 697
Query: 919 IEVKPKNKFALDVD 932
EV FA+DVD
Sbjct: 698 AEV-----FAVDVD 706
Score = 83.0 bits (196), Expect = 7e-15
Identities = 116/467 (24%), Positives = 190/467 (40%), Gaps = 63/467 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN I + +A D D+G NG YE + S D +E E+
Sbjct: 151 IPENTLINSRFPIPSATDPDTGFNGVQHYELLNG----QSVFGLDIVETPE----GEKWP 202
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNIS--VRVFVKDVNDHFPVFKKTWYNFNVE 1055
+IV ++L E + + + I DGG + + ++V V DVND+ PVFK+ ++
Sbjct: 203 QLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIP 262
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYF----IQPSDTDLPFEISPLTGVLSVNGELDRE 1111
E + ++ ATDAD G NA + Y + P+ L F ++ TG+++V LDRE
Sbjct: 263 ENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FALNNTTGLITVQRSLDRE 321
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF---YAFDELLEWKHPEADEL 1168
+ +TV+A D DVNDN P Y + + +
Sbjct: 322 ETAIHKVTVLASDG---SSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDP 378
Query: 1169 SNHNFESVMMIPVYKATIEENAPIGTTVAKVF------ANDTDFIGNGNGLILYSLPQRK 1222
N + +I V + N + + + D ++ + L+ Y +
Sbjct: 379 VN---TKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEF 435
Query: 1223 N----QQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVS 1278
+ + G PSL+ TA++ V + D E + P+F EL + EN + L +
Sbjct: 436 SFKIVASDSGKPSLNQTALVRVKLED-----ENDNPPIFNQPVIELSVSENNRRGLYLTT 490
Query: 1279 LNLTEHYENFKMR-YYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAER 1337
++ T+ Y L N + F +D + G L R DRE ++ + V A R
Sbjct: 491 ISATDEDSGKNADIVYQLGPNAS----FFDLDRKTGVLTASRVFDREEQERFIFTVTA-R 545
Query: 1338 QKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGN 1384
+ L + V+V + D NDNSPKFT+ +
Sbjct: 546 DNGTPPL----------------QSQAAVIVTVLDENDNSPKFTHNH 576
Score = 80.6 bits (190), Expect = 4e-14
Identities = 58/188 (30%), Positives = 85/188 (45%), Gaps = 9/188 (4%)
Query: 198 QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEK 257
Q VI S ++ L+ I A D+D G A + Y+L G + F LD G L +
Sbjct: 471 QPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASR 528
Query: 258 ELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVE 317
D + + F+ V A P +QA V + +LD NDN P+F + + + E
Sbjct: 529 VFDREEQER-----FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSE 583
Query: 318 NLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSL 377
NLP +V + TD D GEN T + + F +DP SG +++ DRE SS
Sbjct: 584 NLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSG--VIKSNVSFDREQQSSY 641
Query: 378 RMKVYAKE 385
V A +
Sbjct: 642 TFDVKATD 649
Score = 79.4 bits (187), Expect = 9e-14
Identities = 60/180 (33%), Positives = 91/180 (50%), Gaps = 14/180 (7%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNL---QAN 270
FP P A D D G YEL++G + +F LD V EK L + NL Q +
Sbjct: 161 FPIP-SATDPDTGFNGVQHYELLNG--QSVFGLDIVETPEG-EKWPQLIVQQNLDREQKD 216
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
T+V++++ P K++ A +++ + D+NDN P F+ + I EN P G SV+Q+ A
Sbjct: 217 TYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHA 276
Query: 331 TDKDQGENGEFTY-----QLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TD D G N E Y K F+++ +G +TV Q LDRE + ++ V A +
Sbjct: 277 TDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITV--QRSLDREETAIHKVTVLASD 334
Score = 64.5 bits (150), Expect = 3e-09
Identities = 68/270 (25%), Positives = 116/270 (42%), Gaps = 24/270 (8%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V L D NDN P+F + E S+ N + G + + A D D G+N ++Y L ++
Sbjct: 455 VRVKLEDENDNPPIF-NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS 513
Query: 505 LTITSPFKINPNTG--TVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F ++ TG T S + R V A D P + + ++ V ++
Sbjct: 514 F-----FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLD---- 564
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN--DAFEQNDVSYDLLHGYEEGVPF 620
+ P F ++F+V N+ ++VG I V DA E V+ +L+ + F
Sbjct: 565 ---ENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---F 618
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTNATVHVVDVNDERGVLLKG 679
++ SGVI R + Y F+ A S T++V+DVND V++
Sbjct: 619 VLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVI-S 677
Query: 680 AHSPIIFHVKENSA--GAAIGQIFHTNMSS 707
S F + SA G+ + ++F ++ +
Sbjct: 678 PPSNTSFKLVPLSAIPGSVVAEVFAVDVDT 707
Score = 63.7 bits (148), Expect = 5e-09
Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 2/114 (1%)
Query: 272 FVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMAT 331
F ++ AS P A V ++L D NDN P F +S+ EN G + + AT
Sbjct: 435 FSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISAT 494
Query: 332 DKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D+D G+N + YQL F +D ++G LT V DRE V A++
Sbjct: 495 DEDSGKNADIVYQLGPNASFFDLDRKTGVLTA--SRVFDREEQERFIFTVTARD 546
Score = 62.9 bits (146), Expect = 9e-09
Identities = 99/390 (25%), Positives = 155/390 (39%), Gaps = 62/390 (15%)
Query: 940 IPENIPIGTTIIKLNALDLDS--GLNGQIRYEFNSEVYIPPS-KLSADALEVKRYFVINE 996
+PEN+PIG LN +++ G + + Y S+ P K+S+ E+ F +
Sbjct: 34 LPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEI---FTTSN 90
Query: 997 R--HGHVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
R + S E+E F L + L I +++ VKD ND+ P+F N
Sbjct: 91 RIDREKLCAGASYAEENECFFELEVVILPNDFFR-LIKIKIIVKDTNDNAPMFPSPVINI 149
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGE 1107
++ E ATD D G N Y + + +I L V
Sbjct: 150 SIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQN 209
Query: 1108 LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE 1167
LDRE +D Y++ + D G DVNDN P F + +
Sbjct: 210 LDREQKDTYVMKIKVEDGG-TPQKSSTAILQVTVSDVNDNRPVF------------KEGQ 256
Query: 1168 LSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL 1227
+ H IP ENAP+GT+V ++ A D D IG+ N I Y +
Sbjct: 257 VEVH-------IP-------ENAPVGTSVIQLHATDAD-IGS-NAEIRYIFGAQVAPATK 300
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN 1287
L +L++T L +TV D E + I + L + + V++N+T+
Sbjct: 301 RLFALNNTTGL-ITVQRSLDREETA-----IHKVTVLASDGSSTPARATVTINVTD---- 350
Query: 1288 FKMRYYILNENDTDIRRTFVIDPRNGTLYL 1317
+N+N +I ++I P NGT+YL
Sbjct: 351 -------VNDNPPNIDLRYIISPINGTVYL 373
Score = 59.7 bits (138), Expect = 8e-08
Identities = 76/320 (23%), Positives = 135/320 (42%), Gaps = 38/320 (11%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE----------LTPTGEKA 116
+V +G ++ V V +ED NDN PIF ++V E ++ T E +
Sbjct: 439 IVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDS 498
Query: 117 F--IFLIAPIGPSLTIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFAL 174
++ +GP+ + + R + R FDR++ + V+ D+G L
Sbjct: 499 GKNADIVYQLGPNASF-FDLDRKTGVLTASRVFDREE-----QERFIFTVTARDNGTPPL 552
Query: 175 ESSHKPVLLLRKVLDYDAG--DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLR 232
+S ++ + D FQ + + + + I D D G +
Sbjct: 553 QSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV----ITVTDADAGENKAVT 608
Query: 233 YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV 292
+++ ND F LD +G ++ + D E Q +++ V+A+ P +++ A+V
Sbjct: 609 LSILNDNDN--FVLDPYSG--VIKSNVSFDRE---QQSSYTFDVKATDGGQPPRSSTAKV 661
Query: 293 EIELLDLNDNLPEFEVDFYNISI----VENLPNGFSVLQVMATDKDQGENGEFTYQL--D 346
I ++D+NDN P N S + +P G V +V A D D G N E Y +
Sbjct: 662 TINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELKYTIVSG 720
Query: 347 DPKGAFSIDPRSGWLTVRNQ 366
+ KG F IDP +G +T+ +
Sbjct: 721 NNKGLFRIDPVTGNITLEEK 740
Score = 59.3 bits (137), Expect = 1e-07
Identities = 47/151 (31%), Positives = 74/151 (49%), Gaps = 10/151 (6%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
S V + ++D NDN+PV + PSN + +A G+V+ +V AVD D G N + Y
Sbjct: 657 STAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYT 716
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVT 556
+ +N + F+I+P TG +++ E P G H L V SD + ++L +V
Sbjct: 717 IVSGNNKGL---FRIDPVTGNITLEEKPAPTDVGLHRLVVNISD--LGYPKSLHTLVLVF 771
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVG 587
+ V T GN I D + E + N+G
Sbjct: 772 LYV-NDTAGNASYIYDLIRRTMETPLDRNIG 801
Score = 33.1 bits (72), Expect = 7.9
Identities = 19/46 (41%), Positives = 28/46 (60%), Gaps = 4/46 (8%)
Query: 1441 ATDSDIGINADIRYQILNEQAPR----FAIDPVSGTVRVVAALARD 1482
ATD+DIG NA+IRY + AP FA++ +G + V +L R+
Sbjct: 276 ATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDRE 321
>AL834258-1|CAD38933.1| 1084|Homo sapiens hypothetical protein
protein.
Length = 1084
Score = 142 bits (345), Expect = 7e-33
Identities = 167/629 (26%), Positives = 276/629 (43%), Gaps = 82/629 (13%)
Query: 738 IFTQKPLDREKRDVYRMTV-IAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFI 796
+ Q+ LDRE++D Y M + + + S I QVT+ D NDN PVF+ E I
Sbjct: 51 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV--SDVNDNRPVFKEGQVEVHI 108
Query: 797 MENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG-----KEMFDVDENTGVVKFIGD 851
EN+ +GT + + ATDAD G+NA Y +FG K +F ++ TG++ +
Sbjct: 109 PENAPVGTSVIQ---LHATDADIGSNAEIRY-IFGAQVAPATKRLFALNNTTGLIT-VQR 163
Query: 852 SLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
SLDRE+ ++K++++A D G S+ A + I N + N N +R + + +N
Sbjct: 164 SLDREETAIHKVTVLASD--GSSTPARATVTI-----NVTDVNDNPPNIDLR-YIISPIN 215
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
GT + E P+ T I + D D+ +NG++
Sbjct: 216 GTV------------------------YLSEKDPVNTKIALITVSDKDTDVNGKVICFIE 251
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGG--NLNDNI 1029
EV P L A + +Y + EF I A D G +LN
Sbjct: 252 REV---PFHLKA--VYDNQYLLETSS------LLDYEGTKEFSFKIVASDSGKPSLNQTA 300
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
VRV ++D ND+ P+F + +V E L + ATD D G+NA++ Y + P+ +
Sbjct: 301 LVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS 360
Query: 1090 DLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
F++ TGVL+ + DRE ++++I TV ARDNG D NDNSP
Sbjct: 361 F--FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVL-DENDNSP 417
Query: 1150 KFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGN 1209
KF ++ ++ L ++ +V +I V A EN + T++ + ND +
Sbjct: 418 KFTHN----HFQFFVSENLPKYS--TVGVITVTDADAGENKAV--TLSILNDNDNFVLDP 469
Query: 1210 GNGLILYSLPQRKNQQNL----------GLPSLSSTAILMVTVADVPDEVEMSDKPVFIS 1259
+G+I ++ + QQ+ G P SSTA + + V DV D + P +
Sbjct: 470 YSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNT 529
Query: 1260 RYYELEIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVR 1319
+ + + + V V + N +++Y I++ N+ + F IDP G + L
Sbjct: 530 SFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGL---FRIDPVTGNITLEE 586
Query: 1320 SPDREVKDTYEVIVRAERQKYSRELPHMI 1348
P + ++V Y + L ++
Sbjct: 587 KPAPTDVGLHRLVVNISDLGYPKSLHTLV 615
Score = 122 bits (293), Expect = 1e-26
Identities = 151/545 (27%), Positives = 232/545 (42%), Gaps = 52/545 (9%)
Query: 402 KWRRQPLETNAPLE-KTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFV 460
KW + ++ N E K TYV KV + Q S ++VT+ D NDN PVF
Sbjct: 47 KWPQLIVQQNLDREQKDTYVMKIKVE------DGGTPQKSSTAILQVTVSDVNDNRPVFK 100
Query: 461 PSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTV 520
+ E + NA VGT + ++ A D D+G N + Y F +N TG +
Sbjct: 101 EGQV-EVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLI 159
Query: 521 SVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAP 577
+V S E H + V ASD + P+ A VTI VT N P+I ++ +P
Sbjct: 160 TVQRSLDREETAIHKVTVLASDGSSTPAR-----ATVTINVT-DVNDNPPNIDLRYIISP 213
Query: 578 YE--FWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF---AVEERSGVITVV 632
++ + T + I V+D + DV+ ++ E VPF AV + ++
Sbjct: 214 INGTVYLSEKDPVNTKIALITVSD--KDTDVNGKVICFIEREVPFHLKAVYDNQYLLETS 271
Query: 633 DDLSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLLKGAHSPII-FHVKE 690
L + F+ VA +L+ V + D ND + + P+I V E
Sbjct: 272 SLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF----NQPVIELSVSE 327
Query: 691 NSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKR 749
N+ G + I T+ S G V L N D + G + + DRE++
Sbjct: 328 NNRRGLYLTTISATDEDS--GKNADIVYQLGPNASFFDLD---RKTGVLTASRVFDREEQ 382
Query: 750 DVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMD 809
+ + TV A N G V + + DENDN P F H ++ F+ EN + +
Sbjct: 383 ERFIFTVTARDN-GTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTV--- 438
Query: 810 NIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARD 869
+I TDAD G N ++ + + F +D +GV+K S DRE++ Y + A D
Sbjct: 439 GVITVTDADAGENKAVTLSILND-NDNFVLDPYSGVIK-SNVSFDREQQSSYTFDVKATD 496
Query: 870 TG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKF 927
G SS A++ I + D NDN P N+ ++ L+ G + EV F
Sbjct: 497 GGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKL---VPLSAIPGSVVAEV-----F 548
Query: 928 ALDVD 932
A+DVD
Sbjct: 549 AVDVD 553
Score = 80.6 bits (190), Expect = 4e-14
Identities = 58/188 (30%), Positives = 85/188 (45%), Gaps = 9/188 (4%)
Query: 198 QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEK 257
Q VI S ++ L+ I A D+D G A + Y+L G + F LD G L +
Sbjct: 318 QPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASR 375
Query: 258 ELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVE 317
D + + F+ V A P +QA V + +LD NDN P+F + + + E
Sbjct: 376 VFDREEQER-----FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSE 430
Query: 318 NLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSL 377
NLP +V + TD D GEN T + + F +DP SG +++ DRE SS
Sbjct: 431 NLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSG--VIKSNVSFDREQQSSY 488
Query: 378 RMKVYAKE 385
V A +
Sbjct: 489 TFDVKATD 496
Score = 79.4 bits (187), Expect = 9e-14
Identities = 60/180 (33%), Positives = 91/180 (50%), Gaps = 14/180 (7%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNL---QAN 270
FP P A D D G YEL++G + +F LD V EK L + NL Q +
Sbjct: 8 FPIP-SATDPDTGFNGVQHYELLNG--QSVFGLDIVETPEG-EKWPQLIVQQNLDREQKD 63
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
T+V++++ P K++ A +++ + D+NDN P F+ + I EN P G SV+Q+ A
Sbjct: 64 TYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHA 123
Query: 331 TDKDQGENGEFTY-----QLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TD D G N E Y K F+++ +G +TV Q LDRE + ++ V A +
Sbjct: 124 TDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITV--QRSLDREETAIHKVTVLASD 181
Score = 77.8 bits (183), Expect = 3e-13
Identities = 111/453 (24%), Positives = 184/453 (40%), Gaps = 63/453 (13%)
Query: 954 NALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE- 1012
+A D D+G NG YE + S D +E E+ +IV ++L E +
Sbjct: 12 SATDPDTGFNGVQHYELLNG----QSVFGLDIVETPE----GEKWPQLIVQQNLDREQKD 63
Query: 1013 -FRLNISALDGGNLNDNIS--VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + I DGG + + ++V V DVND+ PVFK+ ++ E + ++ A
Sbjct: 64 TYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHA 123
Query: 1070 TDADFGQNANLTYF----IQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
TDAD G NA + Y + P+ L F ++ TG+++V LDRE + +TV+A D
Sbjct: 124 TDADIGSNAEIRYIFGAQVAPATKRL-FALNNTTGLITVQRSLDREETAIHKVTVLASDG 182
Query: 1126 GXXXXXXXXXXXXXXXXDVNDNSPKF---YAFDELLEWKHPEADELSNHNFESVMMIPVY 1182
DVNDN P Y + + + N + +I V
Sbjct: 183 ---SSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVN---TKIALITVS 236
Query: 1183 KATIEENAPIGTTVAKVF------ANDTDFIGNGNGLILYSLPQRKN----QQNLGLPSL 1232
+ N + + + D ++ + L+ Y + + + G PSL
Sbjct: 237 DKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSL 296
Query: 1233 SSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENFKMR- 1291
+ TA++ V + D E + P+F EL + EN + L +++ T+
Sbjct: 297 NQTALVRVKLED-----ENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADI 351
Query: 1292 YYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPV 1351
Y L N + F +D + G L R DRE ++ + V A R + L
Sbjct: 352 VYQLGPNAS----FFDLDRKTGVLTASRVFDREEQERFIFTVTA-RDNGTPPL------- 399
Query: 1352 AEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGN 1384
+ V+V + D NDNSPKFT+ +
Sbjct: 400 ---------QSQAAVIVTVLDENDNSPKFTHNH 423
Score = 64.5 bits (150), Expect = 3e-09
Identities = 68/270 (25%), Positives = 116/270 (42%), Gaps = 24/270 (8%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V L D NDN P+F + E S+ N + G + + A D D G+N ++Y L ++
Sbjct: 302 VRVKLEDENDNPPIF-NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS 360
Query: 505 LTITSPFKINPNTG--TVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F ++ TG T S + R V A D P + + ++ V ++
Sbjct: 361 F-----FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLD---- 411
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN--DAFEQNDVSYDLLHGYEEGVPF 620
+ P F ++F+V N+ ++VG I V DA E V+ +L+ + F
Sbjct: 412 ---ENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---F 465
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTNATVHVVDVNDERGVLLKG 679
++ SGVI R + Y F+ A S T++V+DVND V++
Sbjct: 466 VLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVI-S 524
Query: 680 AHSPIIFHVKENSA--GAAIGQIFHTNMSS 707
S F + SA G+ + ++F ++ +
Sbjct: 525 PPSNTSFKLVPLSAIPGSVVAEVFAVDVDT 554
Score = 63.7 bits (148), Expect = 5e-09
Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 2/114 (1%)
Query: 272 FVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMAT 331
F ++ AS P A V ++L D NDN P F +S+ EN G + + AT
Sbjct: 282 FSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISAT 341
Query: 332 DKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D+D G+N + YQL F +D ++G LT V DRE V A++
Sbjct: 342 DEDSGKNADIVYQLGPNASFFDLDRKTGVLTA--SRVFDREEQERFIFTVTARD 393
Score = 59.7 bits (138), Expect = 8e-08
Identities = 76/320 (23%), Positives = 135/320 (42%), Gaps = 38/320 (11%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE----------LTPTGEKA 116
+V +G ++ V V +ED NDN PIF ++V E ++ T E +
Sbjct: 286 IVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDS 345
Query: 117 F--IFLIAPIGPSLTIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFAL 174
++ +GP+ + + R + R FDR++ + V+ D+G L
Sbjct: 346 GKNADIVYQLGPNASF-FDLDRKTGVLTASRVFDREE-----QERFIFTVTARDNGTPPL 399
Query: 175 ESSHKPVLLLRKVLDYDAG--DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLR 232
+S ++ + D FQ + + + + I D D G +
Sbjct: 400 QSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV----ITVTDADAGENKAVT 455
Query: 233 YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV 292
+++ ND F LD +G ++ + D E Q +++ V+A+ P +++ A+V
Sbjct: 456 LSILNDNDN--FVLDPYSG--VIKSNVSFDRE---QQSSYTFDVKATDGGQPPRSSTAKV 508
Query: 293 EIELLDLNDNLPEFEVDFYNISI----VENLPNGFSVLQVMATDKDQGENGEFTYQL--D 346
I ++D+NDN P N S + +P G V +V A D D G N E Y +
Sbjct: 509 TINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELKYTIVSG 567
Query: 347 DPKGAFSIDPRSGWLTVRNQ 366
+ KG F IDP +G +T+ +
Sbjct: 568 NNKGLFRIDPVTGNITLEEK 587
Score = 59.3 bits (137), Expect = 1e-07
Identities = 47/151 (31%), Positives = 74/151 (49%), Gaps = 10/151 (6%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
S V + ++D NDN+PV + PSN + +A G+V+ +V AVD D G N + Y
Sbjct: 504 STAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYT 563
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVT 556
+ +N + F+I+P TG +++ E P G H L V SD + ++L +V
Sbjct: 564 IVSGNNKGL---FRIDPVTGNITLEEKPAPTDVGLHRLVVNISD--LGYPKSLHTLVLVF 618
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVG 587
+ V T GN I D + E + N+G
Sbjct: 619 LYV-NDTAGNASYIYDLIRRTMETPLDRNIG 648
Score = 33.1 bits (72), Expect = 7.9
Identities = 19/46 (41%), Positives = 28/46 (60%), Gaps = 4/46 (8%)
Query: 1441 ATDSDIGINADIRYQILNEQAPR----FAIDPVSGTVRVVAALARD 1482
ATD+DIG NA+IRY + AP FA++ +G + V +L R+
Sbjct: 123 ATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDRE 168
>AL603863-3|CAM17491.1| 1237|Homo sapiens protocadherin 9 protein.
Length = 1237
Score = 142 bits (345), Expect = 7e-33
Identities = 167/629 (26%), Positives = 276/629 (43%), Gaps = 82/629 (13%)
Query: 738 IFTQKPLDREKRDVYRMTV-IAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFI 796
+ Q+ LDRE++D Y M + + + S I QVT+ D NDN PVF+ E I
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV--SDVNDNRPVFKEGQVEVHI 261
Query: 797 MENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG-----KEMFDVDENTGVVKFIGD 851
EN+ +GT + + ATDAD G+NA Y +FG K +F ++ TG++ +
Sbjct: 262 PENAPVGTSVIQ---LHATDADIGSNAEIRY-IFGAQVAPATKRLFALNNTTGLIT-VQR 316
Query: 852 SLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
SLDRE+ ++K++++A D G S+ A + I N + N N +R + + +N
Sbjct: 317 SLDREETAIHKVTVLASD--GSSTPARATVTI-----NVTDVNDNPPNIDLR-YIISPIN 368
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
GT + E P+ T I + D D+ +NG++
Sbjct: 369 GTV------------------------YLSEKDPVNTKIALITVSDKDTDVNGKVICFIE 404
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGG--NLNDNI 1029
EV P L A + +Y + EF I A D G +LN
Sbjct: 405 REV---PFHLKA--VYDNQYLLETSS------LLDYEGTKEFSFKIVASDSGKPSLNQTA 453
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
VRV ++D ND+ P+F + +V E L + ATD D G+NA++ Y + P+ +
Sbjct: 454 LVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS 513
Query: 1090 DLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
F++ TGVL+ + DRE ++++I TV ARDNG D NDNSP
Sbjct: 514 F--FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVL-DENDNSP 570
Query: 1150 KFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGN 1209
KF ++ ++ L ++ +V +I V A EN + T++ + ND +
Sbjct: 571 KFTHN----HFQFFVSENLPKYS--TVGVITVTDADAGENKAV--TLSILNDNDNFVLDP 622
Query: 1210 GNGLILYSLPQRKNQQNL----------GLPSLSSTAILMVTVADVPDEVEMSDKPVFIS 1259
+G+I ++ + QQ+ G P SSTA + + V DV D + P +
Sbjct: 623 YSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNT 682
Query: 1260 RYYELEIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVR 1319
+ + + + V V + N +++Y I++ N+ + F IDP G + L
Sbjct: 683 SFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGL---FRIDPVTGNITLEE 739
Query: 1320 SPDREVKDTYEVIVRAERQKYSRELPHMI 1348
P + ++V Y + L ++
Sbjct: 740 KPAPTDVGLHRLVVNISDLGYPKSLHTLV 768
Score = 125 bits (301), Expect = 1e-27
Identities = 176/674 (26%), Positives = 278/674 (41%), Gaps = 60/674 (8%)
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGF-SVLQVMATDKD 334
V+ S + T R++ E L + E F+ + +V LPN F ++++ KD
Sbjct: 76 VKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVI-LPNDFFRLIKIKIIVKD 134
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLR-MKVYAKETNPSVVGT 393
+N P SI P + + R + + ++ Y SV G
Sbjct: 135 TNDNAPM---FPSPVINISI-PENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGL 190
Query: 394 -FADSQRIAKWRRQPLETNAPLE-KTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLD 451
++ KW + ++ N E K TYV KV + Q S ++VT+ D
Sbjct: 191 DIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVE------DGGTPQKSSTAILQVTVSD 244
Query: 452 ANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPF 511
NDN PVF + E + NA VGT + ++ A D D+G N + Y F
Sbjct: 245 VNDNRPVFKEGQV-EVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLF 303
Query: 512 KINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPD 569
+N TG ++V S E H + V ASD + P+ A VTI VT N P+
Sbjct: 304 ALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPAR-----ATVTINVT-DVNDNPPN 357
Query: 570 IP-DFMGAPYE--FWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF---AVE 623
I ++ +P ++ + T + I V+D + DV+ ++ E VPF AV
Sbjct: 358 IDLRYIISPINGTVYLSEKDPVNTKIALITVSD--KDTDVNGKVICFIEREVPFHLKAVY 415
Query: 624 ERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLLKGAHS 682
+ ++ L + F+ VA +L+ V + D ND + +
Sbjct: 416 DNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF----NQ 471
Query: 683 PII-FHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
P+I V EN+ G + I T+ S G V L N D + G +
Sbjct: 472 PVIELSVSENNRRGLYLTTISATDEDS--GKNADIVYQLGPNASFFDLD---RKTGVLTA 526
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
+ DRE+++ + TV A N G V + + DENDN P F H ++ F+ EN
Sbjct: 527 SRVFDREEQERFIFTVTARDN-GTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL 585
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIM 860
+ + +I TDAD G N ++ + + F +D +GV+K S DRE++
Sbjct: 586 PKYSTV---GVITVTDADAGENKAVTLSILND-NDNFVLDPYSGVIK-SNVSFDREQQSS 640
Query: 861 YKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTI 918
Y + A D G SS A++ I + D NDN P N+ ++ L+ G +
Sbjct: 641 YTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKL---VPLSAIPGSVV 697
Query: 919 IEVKPKNKFALDVD 932
EV FA+DVD
Sbjct: 698 AEV-----FAVDVD 706
Score = 83.0 bits (196), Expect = 7e-15
Identities = 116/467 (24%), Positives = 190/467 (40%), Gaps = 63/467 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN I + +A D D+G NG YE + S D +E E+
Sbjct: 151 IPENTLINSRFPIPSATDPDTGFNGVQHYELLNG----QSVFGLDIVETPE----GEKWP 202
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNIS--VRVFVKDVNDHFPVFKKTWYNFNVE 1055
+IV ++L E + + + I DGG + + ++V V DVND+ PVFK+ ++
Sbjct: 203 QLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIP 262
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYF----IQPSDTDLPFEISPLTGVLSVNGELDRE 1111
E + ++ ATDAD G NA + Y + P+ L F ++ TG+++V LDRE
Sbjct: 263 ENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FALNNTTGLITVQRSLDRE 321
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF---YAFDELLEWKHPEADEL 1168
+ +TV+A D DVNDN P Y + + +
Sbjct: 322 ETAIHKVTVLASDG---SSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDP 378
Query: 1169 SNHNFESVMMIPVYKATIEENAPIGTTVAKVF------ANDTDFIGNGNGLILYSLPQRK 1222
N + +I V + N + + + D ++ + L+ Y +
Sbjct: 379 VN---TKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEF 435
Query: 1223 N----QQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVS 1278
+ + G PSL+ TA++ V + D E + P+F EL + EN + L +
Sbjct: 436 SFKIVASDSGKPSLNQTALVRVKLED-----ENDNPPIFNQPVIELSVSENNRRGLYLTT 490
Query: 1279 LNLTEHYENFKMR-YYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAER 1337
++ T+ Y L N + F +D + G L R DRE ++ + V A R
Sbjct: 491 ISATDEDSGKNADIVYQLGPNAS----FFDLDRKTGVLTASRVFDREEQERFIFTVTA-R 545
Query: 1338 QKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGN 1384
+ L + V+V + D NDNSPKFT+ +
Sbjct: 546 DNGTPPL----------------QSQAAVIVTVLDENDNSPKFTHNH 576
Score = 80.6 bits (190), Expect = 4e-14
Identities = 58/188 (30%), Positives = 85/188 (45%), Gaps = 9/188 (4%)
Query: 198 QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEK 257
Q VI S ++ L+ I A D+D G A + Y+L G + F LD G L +
Sbjct: 471 QPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASR 528
Query: 258 ELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVE 317
D + + F+ V A P +QA V + +LD NDN P+F + + + E
Sbjct: 529 VFDREEQER-----FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSE 583
Query: 318 NLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSL 377
NLP +V + TD D GEN T + + F +DP SG +++ DRE SS
Sbjct: 584 NLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSG--VIKSNVSFDREQQSSY 641
Query: 378 RMKVYAKE 385
V A +
Sbjct: 642 TFDVKATD 649
Score = 79.4 bits (187), Expect = 9e-14
Identities = 60/180 (33%), Positives = 91/180 (50%), Gaps = 14/180 (7%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNL---QAN 270
FP P A D D G YEL++G + +F LD V EK L + NL Q +
Sbjct: 161 FPIP-SATDPDTGFNGVQHYELLNG--QSVFGLDIVETPEG-EKWPQLIVQQNLDREQKD 216
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
T+V++++ P K++ A +++ + D+NDN P F+ + I EN P G SV+Q+ A
Sbjct: 217 TYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHA 276
Query: 331 TDKDQGENGEFTY-----QLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TD D G N E Y K F+++ +G +TV Q LDRE + ++ V A +
Sbjct: 277 TDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITV--QRSLDREETAIHKVTVLASD 334
Score = 64.5 bits (150), Expect = 3e-09
Identities = 68/270 (25%), Positives = 116/270 (42%), Gaps = 24/270 (8%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V L D NDN P+F + E S+ N + G + + A D D G+N ++Y L ++
Sbjct: 455 VRVKLEDENDNPPIF-NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS 513
Query: 505 LTITSPFKINPNTG--TVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F ++ TG T S + R V A D P + + ++ V ++
Sbjct: 514 F-----FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLD---- 564
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN--DAFEQNDVSYDLLHGYEEGVPF 620
+ P F ++F+V N+ ++VG I V DA E V+ +L+ + F
Sbjct: 565 ---ENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---F 618
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTNATVHVVDVNDERGVLLKG 679
++ SGVI R + Y F+ A S T++V+DVND V++
Sbjct: 619 VLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVI-S 677
Query: 680 AHSPIIFHVKENSA--GAAIGQIFHTNMSS 707
S F + SA G+ + ++F ++ +
Sbjct: 678 PPSNTSFKLVPLSAIPGSVVAEVFAVDVDT 707
Score = 63.7 bits (148), Expect = 5e-09
Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 2/114 (1%)
Query: 272 FVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMAT 331
F ++ AS P A V ++L D NDN P F +S+ EN G + + AT
Sbjct: 435 FSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISAT 494
Query: 332 DKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D+D G+N + YQL F +D ++G LT V DRE V A++
Sbjct: 495 DEDSGKNADIVYQLGPNASFFDLDRKTGVLTA--SRVFDREEQERFIFTVTARD 546
Score = 62.9 bits (146), Expect = 9e-09
Identities = 99/390 (25%), Positives = 155/390 (39%), Gaps = 62/390 (15%)
Query: 940 IPENIPIGTTIIKLNALDLDS--GLNGQIRYEFNSEVYIPPS-KLSADALEVKRYFVINE 996
+PEN+PIG LN +++ G + + Y S+ P K+S+ E+ F +
Sbjct: 34 LPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEI---FTTSN 90
Query: 997 R--HGHVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
R + S E+E F L + L I +++ VKD ND+ P+F N
Sbjct: 91 RIDREKLCAGASYAEENECFFELEVVILPNDFFR-LIKIKIIVKDTNDNAPMFPSPVINI 149
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGE 1107
++ E ATD D G N Y + + +I L V
Sbjct: 150 SIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQN 209
Query: 1108 LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE 1167
LDRE +D Y++ + D G DVNDN P F + +
Sbjct: 210 LDREQKDTYVMKIKVEDGG-TPQKSSTAILQVTVSDVNDNRPVF------------KEGQ 256
Query: 1168 LSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL 1227
+ H IP ENAP+GT+V ++ A D D IG+ N I Y +
Sbjct: 257 VEVH-------IP-------ENAPVGTSVIQLHATDAD-IGS-NAEIRYIFGAQVAPATK 300
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN 1287
L +L++T L +TV D E + I + L + + V++N+T+
Sbjct: 301 RLFALNNTTGL-ITVQRSLDREETA-----IHKVTVLASDGSSTPARATVTINVTD---- 350
Query: 1288 FKMRYYILNENDTDIRRTFVIDPRNGTLYL 1317
+N+N +I ++I P NGT+YL
Sbjct: 351 -------VNDNPPNIDLRYIISPINGTVYL 373
Score = 59.7 bits (138), Expect = 8e-08
Identities = 76/320 (23%), Positives = 135/320 (42%), Gaps = 38/320 (11%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE----------LTPTGEKA 116
+V +G ++ V V +ED NDN PIF ++V E ++ T E +
Sbjct: 439 IVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDS 498
Query: 117 F--IFLIAPIGPSLTIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFAL 174
++ +GP+ + + R + R FDR++ + V+ D+G L
Sbjct: 499 GKNADIVYQLGPNASF-FDLDRKTGVLTASRVFDREE-----QERFIFTVTARDNGTPPL 552
Query: 175 ESSHKPVLLLRKVLDYDAG--DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLR 232
+S ++ + D FQ + + + + I D D G +
Sbjct: 553 QSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV----ITVTDADAGENKAVT 608
Query: 233 YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV 292
+++ ND F LD +G ++ + D E Q +++ V+A+ P +++ A+V
Sbjct: 609 LSILNDNDN--FVLDPYSG--VIKSNVSFDRE---QQSSYTFDVKATDGGQPPRSSTAKV 661
Query: 293 EIELLDLNDNLPEFEVDFYNISI----VENLPNGFSVLQVMATDKDQGENGEFTYQL--D 346
I ++D+NDN P N S + +P G V +V A D D G N E Y +
Sbjct: 662 TINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELKYTIVSG 720
Query: 347 DPKGAFSIDPRSGWLTVRNQ 366
+ KG F IDP +G +T+ +
Sbjct: 721 NNKGLFRIDPVTGNITLEEK 740
Score = 59.3 bits (137), Expect = 1e-07
Identities = 47/151 (31%), Positives = 74/151 (49%), Gaps = 10/151 (6%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
S V + ++D NDN+PV + PSN + +A G+V+ +V AVD D G N + Y
Sbjct: 657 STAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYT 716
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVT 556
+ +N + F+I+P TG +++ E P G H L V SD + ++L +V
Sbjct: 717 IVSGNNKGL---FRIDPVTGNITLEEKPAPTDVGLHRLVVNISD--LGYPKSLHTLVLVF 771
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVG 587
+ V T GN I D + E + N+G
Sbjct: 772 LYV-NDTAGNASYIYDLIRRTMETPLDRNIG 801
Score = 33.1 bits (72), Expect = 7.9
Identities = 19/46 (41%), Positives = 28/46 (60%), Gaps = 4/46 (8%)
Query: 1441 ATDSDIGINADIRYQILNEQAPR----FAIDPVSGTVRVVAALARD 1482
ATD+DIG NA+IRY + AP FA++ +G + V +L R+
Sbjct: 276 ATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDRE 321
>AL603863-2|CAH72759.1| 1203|Homo sapiens protocadherin 9 protein.
Length = 1203
Score = 142 bits (345), Expect = 7e-33
Identities = 167/629 (26%), Positives = 276/629 (43%), Gaps = 82/629 (13%)
Query: 738 IFTQKPLDREKRDVYRMTV-IAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFI 796
+ Q+ LDRE++D Y M + + + S I QVT+ D NDN PVF+ E I
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV--SDVNDNRPVFKEGQVEVHI 261
Query: 797 MENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG-----KEMFDVDENTGVVKFIGD 851
EN+ +GT + + ATDAD G+NA Y +FG K +F ++ TG++ +
Sbjct: 262 PENAPVGTSVIQ---LHATDADIGSNAEIRY-IFGAQVAPATKRLFALNNTTGLIT-VQR 316
Query: 852 SLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
SLDRE+ ++K++++A D G S+ A + I N + N N +R + + +N
Sbjct: 317 SLDREETAIHKVTVLASD--GSSTPARATVTI-----NVTDVNDNPPNIDLR-YIISPIN 368
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
GT + E P+ T I + D D+ +NG++
Sbjct: 369 GTV------------------------YLSEKDPVNTKIALITVSDKDTDVNGKVICFIE 404
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGG--NLNDNI 1029
EV P L A + +Y + EF I A D G +LN
Sbjct: 405 REV---PFHLKA--VYDNQYLLETSS------LLDYEGTKEFSFKIVASDSGKPSLNQTA 453
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
VRV ++D ND+ P+F + +V E L + ATD D G+NA++ Y + P+ +
Sbjct: 454 LVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS 513
Query: 1090 DLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
F++ TGVL+ + DRE ++++I TV ARDNG D NDNSP
Sbjct: 514 F--FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVL-DENDNSP 570
Query: 1150 KFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGN 1209
KF ++ ++ L ++ +V +I V A EN + T++ + ND +
Sbjct: 571 KFTHN----HFQFFVSENLPKYS--TVGVITVTDADAGENKAV--TLSILNDNDNFVLDP 622
Query: 1210 GNGLILYSLPQRKNQQNL----------GLPSLSSTAILMVTVADVPDEVEMSDKPVFIS 1259
+G+I ++ + QQ+ G P SSTA + + V DV D + P +
Sbjct: 623 YSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNT 682
Query: 1260 RYYELEIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVR 1319
+ + + + V V + N +++Y I++ N+ + F IDP G + L
Sbjct: 683 SFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGL---FRIDPVTGNITLEE 739
Query: 1320 SPDREVKDTYEVIVRAERQKYSRELPHMI 1348
P + ++V Y + L ++
Sbjct: 740 KPAPTDVGLHRLVVNISDLGYPKSLHTLV 768
Score = 125 bits (301), Expect = 1e-27
Identities = 176/674 (26%), Positives = 278/674 (41%), Gaps = 60/674 (8%)
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGF-SVLQVMATDKD 334
V+ S + T R++ E L + E F+ + +V LPN F ++++ KD
Sbjct: 76 VKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVI-LPNDFFRLIKIKIIVKD 134
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLR-MKVYAKETNPSVVGT 393
+N P SI P + + R + + ++ Y SV G
Sbjct: 135 TNDNAPM---FPSPVINISI-PENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGL 190
Query: 394 -FADSQRIAKWRRQPLETNAPLE-KTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLD 451
++ KW + ++ N E K TYV KV + Q S ++VT+ D
Sbjct: 191 DIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVE------DGGTPQKSSTAILQVTVSD 244
Query: 452 ANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPF 511
NDN PVF + E + NA VGT + ++ A D D+G N + Y F
Sbjct: 245 VNDNRPVFKEGQV-EVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLF 303
Query: 512 KINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPD 569
+N TG ++V S E H + V ASD + P+ A VTI VT N P+
Sbjct: 304 ALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPAR-----ATVTINVT-DVNDNPPN 357
Query: 570 IP-DFMGAPYE--FWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF---AVE 623
I ++ +P ++ + T + I V+D + DV+ ++ E VPF AV
Sbjct: 358 IDLRYIISPINGTVYLSEKDPVNTKIALITVSD--KDTDVNGKVICFIEREVPFHLKAVY 415
Query: 624 ERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLLKGAHS 682
+ ++ L + F+ VA +L+ V + D ND + +
Sbjct: 416 DNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF----NQ 471
Query: 683 PII-FHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
P+I V EN+ G + I T+ S G V L N D + G +
Sbjct: 472 PVIELSVSENNRRGLYLTTISATDEDS--GKNADIVYQLGPNASFFDLD---RKTGVLTA 526
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
+ DRE+++ + TV A N G V + + DENDN P F H ++ F+ EN
Sbjct: 527 SRVFDREEQERFIFTVTARDN-GTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL 585
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIM 860
+ + +I TDAD G N ++ + + F +D +GV+K S DRE++
Sbjct: 586 PKYSTV---GVITVTDADAGENKAVTLSILND-NDNFVLDPYSGVIK-SNVSFDREQQSS 640
Query: 861 YKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTI 918
Y + A D G SS A++ I + D NDN P N+ ++ L+ G +
Sbjct: 641 YTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKL---VPLSAIPGSVV 697
Query: 919 IEVKPKNKFALDVD 932
EV FA+DVD
Sbjct: 698 AEV-----FAVDVD 706
Score = 83.0 bits (196), Expect = 7e-15
Identities = 116/467 (24%), Positives = 190/467 (40%), Gaps = 63/467 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN I + +A D D+G NG YE + S D +E E+
Sbjct: 151 IPENTLINSRFPIPSATDPDTGFNGVQHYELLNG----QSVFGLDIVETPE----GEKWP 202
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNIS--VRVFVKDVNDHFPVFKKTWYNFNVE 1055
+IV ++L E + + + I DGG + + ++V V DVND+ PVFK+ ++
Sbjct: 203 QLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIP 262
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYF----IQPSDTDLPFEISPLTGVLSVNGELDRE 1111
E + ++ ATDAD G NA + Y + P+ L F ++ TG+++V LDRE
Sbjct: 263 ENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FALNNTTGLITVQRSLDRE 321
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF---YAFDELLEWKHPEADEL 1168
+ +TV+A D DVNDN P Y + + +
Sbjct: 322 ETAIHKVTVLASDG---SSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDP 378
Query: 1169 SNHNFESVMMIPVYKATIEENAPIGTTVAKVF------ANDTDFIGNGNGLILYSLPQRK 1222
N + +I V + N + + + D ++ + L+ Y +
Sbjct: 379 VN---TKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEF 435
Query: 1223 N----QQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVS 1278
+ + G PSL+ TA++ V + D E + P+F EL + EN + L +
Sbjct: 436 SFKIVASDSGKPSLNQTALVRVKLED-----ENDNPPIFNQPVIELSVSENNRRGLYLTT 490
Query: 1279 LNLTEHYENFKMR-YYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAER 1337
++ T+ Y L N + F +D + G L R DRE ++ + V A R
Sbjct: 491 ISATDEDSGKNADIVYQLGPNAS----FFDLDRKTGVLTASRVFDREEQERFIFTVTA-R 545
Query: 1338 QKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGN 1384
+ L + V+V + D NDNSPKFT+ +
Sbjct: 546 DNGTPPL----------------QSQAAVIVTVLDENDNSPKFTHNH 576
Score = 80.6 bits (190), Expect = 4e-14
Identities = 58/188 (30%), Positives = 85/188 (45%), Gaps = 9/188 (4%)
Query: 198 QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEK 257
Q VI S ++ L+ I A D+D G A + Y+L G + F LD G L +
Sbjct: 471 QPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASR 528
Query: 258 ELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVE 317
D + + F+ V A P +QA V + +LD NDN P+F + + + E
Sbjct: 529 VFDREEQER-----FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSE 583
Query: 318 NLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSL 377
NLP +V + TD D GEN T + + F +DP SG +++ DRE SS
Sbjct: 584 NLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSG--VIKSNVSFDREQQSSY 641
Query: 378 RMKVYAKE 385
V A +
Sbjct: 642 TFDVKATD 649
Score = 79.4 bits (187), Expect = 9e-14
Identities = 60/180 (33%), Positives = 91/180 (50%), Gaps = 14/180 (7%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNL---QAN 270
FP P A D D G YEL++G + +F LD V EK L + NL Q +
Sbjct: 161 FPIP-SATDPDTGFNGVQHYELLNG--QSVFGLDIVETPEG-EKWPQLIVQQNLDREQKD 216
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
T+V++++ P K++ A +++ + D+NDN P F+ + I EN P G SV+Q+ A
Sbjct: 217 TYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHA 276
Query: 331 TDKDQGENGEFTY-----QLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TD D G N E Y K F+++ +G +TV Q LDRE + ++ V A +
Sbjct: 277 TDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITV--QRSLDREETAIHKVTVLASD 334
Score = 64.5 bits (150), Expect = 3e-09
Identities = 68/270 (25%), Positives = 116/270 (42%), Gaps = 24/270 (8%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V L D NDN P+F + E S+ N + G + + A D D G+N ++Y L ++
Sbjct: 455 VRVKLEDENDNPPIF-NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS 513
Query: 505 LTITSPFKINPNTG--TVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F ++ TG T S + R V A D P + + ++ V ++
Sbjct: 514 F-----FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLD---- 564
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN--DAFEQNDVSYDLLHGYEEGVPF 620
+ P F ++F+V N+ ++VG I V DA E V+ +L+ + F
Sbjct: 565 ---ENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---F 618
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTNATVHVVDVNDERGVLLKG 679
++ SGVI R + Y F+ A S T++V+DVND V++
Sbjct: 619 VLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVI-S 677
Query: 680 AHSPIIFHVKENSA--GAAIGQIFHTNMSS 707
S F + SA G+ + ++F ++ +
Sbjct: 678 PPSNTSFKLVPLSAIPGSVVAEVFAVDVDT 707
Score = 63.7 bits (148), Expect = 5e-09
Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 2/114 (1%)
Query: 272 FVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMAT 331
F ++ AS P A V ++L D NDN P F +S+ EN G + + AT
Sbjct: 435 FSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISAT 494
Query: 332 DKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D+D G+N + YQL F +D ++G LT V DRE V A++
Sbjct: 495 DEDSGKNADIVYQLGPNASFFDLDRKTGVLTA--SRVFDREEQERFIFTVTARD 546
Score = 62.9 bits (146), Expect = 9e-09
Identities = 99/390 (25%), Positives = 155/390 (39%), Gaps = 62/390 (15%)
Query: 940 IPENIPIGTTIIKLNALDLDS--GLNGQIRYEFNSEVYIPPS-KLSADALEVKRYFVINE 996
+PEN+PIG LN +++ G + + Y S+ P K+S+ E+ F +
Sbjct: 34 LPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEI---FTTSN 90
Query: 997 R--HGHVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
R + S E+E F L + L I +++ VKD ND+ P+F N
Sbjct: 91 RIDREKLCAGASYAEENECFFELEVVILPNDFFR-LIKIKIIVKDTNDNAPMFPSPVINI 149
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGE 1107
++ E ATD D G N Y + + +I L V
Sbjct: 150 SIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQN 209
Query: 1108 LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE 1167
LDRE +D Y++ + D G DVNDN P F + +
Sbjct: 210 LDREQKDTYVMKIKVEDGG-TPQKSSTAILQVTVSDVNDNRPVF------------KEGQ 256
Query: 1168 LSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL 1227
+ H IP ENAP+GT+V ++ A D D IG+ N I Y +
Sbjct: 257 VEVH-------IP-------ENAPVGTSVIQLHATDAD-IGS-NAEIRYIFGAQVAPATK 300
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN 1287
L +L++T L +TV D E + I + L + + V++N+T+
Sbjct: 301 RLFALNNTTGL-ITVQRSLDREETA-----IHKVTVLASDGSSTPARATVTINVTD---- 350
Query: 1288 FKMRYYILNENDTDIRRTFVIDPRNGTLYL 1317
+N+N +I ++I P NGT+YL
Sbjct: 351 -------VNDNPPNIDLRYIISPINGTVYL 373
Score = 59.7 bits (138), Expect = 8e-08
Identities = 76/320 (23%), Positives = 135/320 (42%), Gaps = 38/320 (11%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE----------LTPTGEKA 116
+V +G ++ V V +ED NDN PIF ++V E ++ T E +
Sbjct: 439 IVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDS 498
Query: 117 F--IFLIAPIGPSLTIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFAL 174
++ +GP+ + + R + R FDR++ + V+ D+G L
Sbjct: 499 GKNADIVYQLGPNASF-FDLDRKTGVLTASRVFDREE-----QERFIFTVTARDNGTPPL 552
Query: 175 ESSHKPVLLLRKVLDYDAG--DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLR 232
+S ++ + D FQ + + + + I D D G +
Sbjct: 553 QSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV----ITVTDADAGENKAVT 608
Query: 233 YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV 292
+++ ND F LD +G ++ + D E Q +++ V+A+ P +++ A+V
Sbjct: 609 LSILNDNDN--FVLDPYSG--VIKSNVSFDRE---QQSSYTFDVKATDGGQPPRSSTAKV 661
Query: 293 EIELLDLNDNLPEFEVDFYNISI----VENLPNGFSVLQVMATDKDQGENGEFTYQL--D 346
I ++D+NDN P N S + +P G V +V A D D G N E Y +
Sbjct: 662 TINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELKYTIVSG 720
Query: 347 DPKGAFSIDPRSGWLTVRNQ 366
+ KG F IDP +G +T+ +
Sbjct: 721 NNKGLFRIDPVTGNITLEEK 740
Score = 59.3 bits (137), Expect = 1e-07
Identities = 47/151 (31%), Positives = 74/151 (49%), Gaps = 10/151 (6%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
S V + ++D NDN+PV + PSN + +A G+V+ +V AVD D G N + Y
Sbjct: 657 STAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYT 716
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVT 556
+ +N + F+I+P TG +++ E P G H L V SD + ++L +V
Sbjct: 717 IVSGNNKGL---FRIDPVTGNITLEEKPAPTDVGLHRLVVNISD--LGYPKSLHTLVLVF 771
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVG 587
+ V T GN I D + E + N+G
Sbjct: 772 LYV-NDTAGNASYIYDLIRRTMETPLDRNIG 801
Score = 33.1 bits (72), Expect = 7.9
Identities = 19/46 (41%), Positives = 28/46 (60%), Gaps = 4/46 (8%)
Query: 1441 ATDSDIGINADIRYQILNEQAPR----FAIDPVSGTVRVVAALARD 1482
ATD+DIG NA+IRY + AP FA++ +G + V +L R+
Sbjct: 276 ATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDRE 321
>AL603863-1|CAH72758.1| 1032|Homo sapiens protocadherin 9 protein.
Length = 1032
Score = 142 bits (345), Expect = 7e-33
Identities = 167/629 (26%), Positives = 276/629 (43%), Gaps = 82/629 (13%)
Query: 738 IFTQKPLDREKRDVYRMTV-IAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFI 796
+ Q+ LDRE++D Y M + + + S I QVT+ D NDN PVF+ E I
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV--SDVNDNRPVFKEGQVEVHI 261
Query: 797 MENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG-----KEMFDVDENTGVVKFIGD 851
EN+ +GT + + ATDAD G+NA Y +FG K +F ++ TG++ +
Sbjct: 262 PENAPVGTSVIQ---LHATDADIGSNAEIRY-IFGAQVAPATKRLFALNNTTGLIT-VQR 316
Query: 852 SLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
SLDRE+ ++K++++A D G S+ A + I N + N N +R + + +N
Sbjct: 317 SLDREETAIHKVTVLASD--GSSTPARATVTI-----NVTDVNDNPPNIDLR-YIISPIN 368
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
GT + E P+ T I + D D+ +NG++
Sbjct: 369 GTV------------------------YLSEKDPVNTKIALITVSDKDTDVNGKVICFIE 404
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGG--NLNDNI 1029
EV P L A + +Y + EF I A D G +LN
Sbjct: 405 REV---PFHLKA--VYDNQYLLETSS------LLDYEGTKEFSFKIVASDSGKPSLNQTA 453
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
VRV ++D ND+ P+F + +V E L + ATD D G+NA++ Y + P+ +
Sbjct: 454 LVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS 513
Query: 1090 DLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
F++ TGVL+ + DRE ++++I TV ARDNG D NDNSP
Sbjct: 514 F--FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVL-DENDNSP 570
Query: 1150 KFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGN 1209
KF ++ ++ L ++ +V +I V A EN + T++ + ND +
Sbjct: 571 KFTHN----HFQFFVSENLPKYS--TVGVITVTDADAGENKAV--TLSILNDNDNFVLDP 622
Query: 1210 GNGLILYSLPQRKNQQNL----------GLPSLSSTAILMVTVADVPDEVEMSDKPVFIS 1259
+G+I ++ + QQ+ G P SSTA + + V DV D + P +
Sbjct: 623 YSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNT 682
Query: 1260 RYYELEIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVR 1319
+ + + + V V + N +++Y I++ N+ + F IDP G + L
Sbjct: 683 SFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGL---FRIDPVTGNITLEE 739
Query: 1320 SPDREVKDTYEVIVRAERQKYSRELPHMI 1348
P + ++V Y + L ++
Sbjct: 740 KPAPTDVGLHRLVVNISDLGYPKSLHTLV 768
Score = 125 bits (301), Expect = 1e-27
Identities = 176/674 (26%), Positives = 278/674 (41%), Gaps = 60/674 (8%)
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGF-SVLQVMATDKD 334
V+ S + T R++ E L + E F+ + +V LPN F ++++ KD
Sbjct: 76 VKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVI-LPNDFFRLIKIKIIVKD 134
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLR-MKVYAKETNPSVVGT 393
+N P SI P + + R + + ++ Y SV G
Sbjct: 135 TNDNAPM---FPSPVINISI-PENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGL 190
Query: 394 -FADSQRIAKWRRQPLETNAPLE-KTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLD 451
++ KW + ++ N E K TYV KV + Q S ++VT+ D
Sbjct: 191 DIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVE------DGGTPQKSSTAILQVTVSD 244
Query: 452 ANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPF 511
NDN PVF + E + NA VGT + ++ A D D+G N + Y F
Sbjct: 245 VNDNRPVFKEGQV-EVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLF 303
Query: 512 KINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPD 569
+N TG ++V S E H + V ASD + P+ A VTI VT N P+
Sbjct: 304 ALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPAR-----ATVTINVT-DVNDNPPN 357
Query: 570 IP-DFMGAPYE--FWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF---AVE 623
I ++ +P ++ + T + I V+D + DV+ ++ E VPF AV
Sbjct: 358 IDLRYIISPINGTVYLSEKDPVNTKIALITVSD--KDTDVNGKVICFIEREVPFHLKAVY 415
Query: 624 ERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLLKGAHS 682
+ ++ L + F+ VA +L+ V + D ND + +
Sbjct: 416 DNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF----NQ 471
Query: 683 PII-FHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
P+I V EN+ G + I T+ S G V L N D + G +
Sbjct: 472 PVIELSVSENNRRGLYLTTISATDEDS--GKNADIVYQLGPNASFFDLD---RKTGVLTA 526
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
+ DRE+++ + TV A N G V + + DENDN P F H ++ F+ EN
Sbjct: 527 SRVFDREEQERFIFTVTARDN-GTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL 585
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIM 860
+ + +I TDAD G N ++ + + F +D +GV+K S DRE++
Sbjct: 586 PKYSTV---GVITVTDADAGENKAVTLSILND-NDNFVLDPYSGVIK-SNVSFDREQQSS 640
Query: 861 YKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTI 918
Y + A D G SS A++ I + D NDN P N+ ++ L+ G +
Sbjct: 641 YTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKL---VPLSAIPGSVV 697
Query: 919 IEVKPKNKFALDVD 932
EV FA+DVD
Sbjct: 698 AEV-----FAVDVD 706
Score = 83.0 bits (196), Expect = 7e-15
Identities = 116/467 (24%), Positives = 190/467 (40%), Gaps = 63/467 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN I + +A D D+G NG YE + S D +E E+
Sbjct: 151 IPENTLINSRFPIPSATDPDTGFNGVQHYELLNG----QSVFGLDIVETPE----GEKWP 202
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNIS--VRVFVKDVNDHFPVFKKTWYNFNVE 1055
+IV ++L E + + + I DGG + + ++V V DVND+ PVFK+ ++
Sbjct: 203 QLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIP 262
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYF----IQPSDTDLPFEISPLTGVLSVNGELDRE 1111
E + ++ ATDAD G NA + Y + P+ L F ++ TG+++V LDRE
Sbjct: 263 ENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FALNNTTGLITVQRSLDRE 321
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF---YAFDELLEWKHPEADEL 1168
+ +TV+A D DVNDN P Y + + +
Sbjct: 322 ETAIHKVTVLASDG---SSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDP 378
Query: 1169 SNHNFESVMMIPVYKATIEENAPIGTTVAKVF------ANDTDFIGNGNGLILYSLPQRK 1222
N + +I V + N + + + D ++ + L+ Y +
Sbjct: 379 VN---TKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEF 435
Query: 1223 N----QQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVS 1278
+ + G PSL+ TA++ V + D E + P+F EL + EN + L +
Sbjct: 436 SFKIVASDSGKPSLNQTALVRVKLED-----ENDNPPIFNQPVIELSVSENNRRGLYLTT 490
Query: 1279 LNLTEHYENFKMR-YYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAER 1337
++ T+ Y L N + F +D + G L R DRE ++ + V A R
Sbjct: 491 ISATDEDSGKNADIVYQLGPNAS----FFDLDRKTGVLTASRVFDREEQERFIFTVTA-R 545
Query: 1338 QKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGN 1384
+ L + V+V + D NDNSPKFT+ +
Sbjct: 546 DNGTPPL----------------QSQAAVIVTVLDENDNSPKFTHNH 576
Score = 80.6 bits (190), Expect = 4e-14
Identities = 58/188 (30%), Positives = 85/188 (45%), Gaps = 9/188 (4%)
Query: 198 QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEK 257
Q VI S ++ L+ I A D+D G A + Y+L G + F LD G L +
Sbjct: 471 QPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASR 528
Query: 258 ELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVE 317
D + + F+ V A P +QA V + +LD NDN P+F + + + E
Sbjct: 529 VFDREEQER-----FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSE 583
Query: 318 NLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSL 377
NLP +V + TD D GEN T + + F +DP SG +++ DRE SS
Sbjct: 584 NLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSG--VIKSNVSFDREQQSSY 641
Query: 378 RMKVYAKE 385
V A +
Sbjct: 642 TFDVKATD 649
Score = 79.4 bits (187), Expect = 9e-14
Identities = 60/180 (33%), Positives = 91/180 (50%), Gaps = 14/180 (7%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNL---QAN 270
FP P A D D G YEL++G + +F LD V EK L + NL Q +
Sbjct: 161 FPIP-SATDPDTGFNGVQHYELLNG--QSVFGLDIVETPEG-EKWPQLIVQQNLDREQKD 216
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
T+V++++ P K++ A +++ + D+NDN P F+ + I EN P G SV+Q+ A
Sbjct: 217 TYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHA 276
Query: 331 TDKDQGENGEFTY-----QLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TD D G N E Y K F+++ +G +TV Q LDRE + ++ V A +
Sbjct: 277 TDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITV--QRSLDREETAIHKVTVLASD 334
Score = 64.5 bits (150), Expect = 3e-09
Identities = 68/270 (25%), Positives = 116/270 (42%), Gaps = 24/270 (8%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V L D NDN P+F + E S+ N + G + + A D D G+N ++Y L ++
Sbjct: 455 VRVKLEDENDNPPIF-NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS 513
Query: 505 LTITSPFKINPNTG--TVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F ++ TG T S + R V A D P + + ++ V ++
Sbjct: 514 F-----FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLD---- 564
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN--DAFEQNDVSYDLLHGYEEGVPF 620
+ P F ++F+V N+ ++VG I V DA E V+ +L+ + F
Sbjct: 565 ---ENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---F 618
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTNATVHVVDVNDERGVLLKG 679
++ SGVI R + Y F+ A S T++V+DVND V++
Sbjct: 619 VLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVI-S 677
Query: 680 AHSPIIFHVKENSA--GAAIGQIFHTNMSS 707
S F + SA G+ + ++F ++ +
Sbjct: 678 PPSNTSFKLVPLSAIPGSVVAEVFAVDVDT 707
Score = 63.7 bits (148), Expect = 5e-09
Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 2/114 (1%)
Query: 272 FVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMAT 331
F ++ AS P A V ++L D NDN P F +S+ EN G + + AT
Sbjct: 435 FSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISAT 494
Query: 332 DKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D+D G+N + YQL F +D ++G LT V DRE V A++
Sbjct: 495 DEDSGKNADIVYQLGPNASFFDLDRKTGVLTA--SRVFDREEQERFIFTVTARD 546
Score = 62.9 bits (146), Expect = 9e-09
Identities = 99/390 (25%), Positives = 155/390 (39%), Gaps = 62/390 (15%)
Query: 940 IPENIPIGTTIIKLNALDLDS--GLNGQIRYEFNSEVYIPPS-KLSADALEVKRYFVINE 996
+PEN+PIG LN +++ G + + Y S+ P K+S+ E+ F +
Sbjct: 34 LPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEI---FTTSN 90
Query: 997 R--HGHVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
R + S E+E F L + L I +++ VKD ND+ P+F N
Sbjct: 91 RIDREKLCAGASYAEENECFFELEVVILPNDFFR-LIKIKIIVKDTNDNAPMFPSPVINI 149
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGE 1107
++ E ATD D G N Y + + +I L V
Sbjct: 150 SIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQN 209
Query: 1108 LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE 1167
LDRE +D Y++ + D G DVNDN P F + +
Sbjct: 210 LDREQKDTYVMKIKVEDGG-TPQKSSTAILQVTVSDVNDNRPVF------------KEGQ 256
Query: 1168 LSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL 1227
+ H IP ENAP+GT+V ++ A D D IG+ N I Y +
Sbjct: 257 VEVH-------IP-------ENAPVGTSVIQLHATDAD-IGS-NAEIRYIFGAQVAPATK 300
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN 1287
L +L++T L +TV D E + I + L + + V++N+T+
Sbjct: 301 RLFALNNTTGL-ITVQRSLDREETA-----IHKVTVLASDGSSTPARATVTINVTD---- 350
Query: 1288 FKMRYYILNENDTDIRRTFVIDPRNGTLYL 1317
+N+N +I ++I P NGT+YL
Sbjct: 351 -------VNDNPPNIDLRYIISPINGTVYL 373
Score = 59.7 bits (138), Expect = 8e-08
Identities = 76/320 (23%), Positives = 135/320 (42%), Gaps = 38/320 (11%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE----------LTPTGEKA 116
+V +G ++ V V +ED NDN PIF ++V E ++ T E +
Sbjct: 439 IVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDS 498
Query: 117 F--IFLIAPIGPSLTIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFAL 174
++ +GP+ + + R + R FDR++ + V+ D+G L
Sbjct: 499 GKNADIVYQLGPNASF-FDLDRKTGVLTASRVFDREE-----QERFIFTVTARDNGTPPL 552
Query: 175 ESSHKPVLLLRKVLDYDAG--DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLR 232
+S ++ + D FQ + + + + I D D G +
Sbjct: 553 QSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV----ITVTDADAGENKAVT 608
Query: 233 YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV 292
+++ ND F LD +G ++ + D E Q +++ V+A+ P +++ A+V
Sbjct: 609 LSILNDNDN--FVLDPYSG--VIKSNVSFDRE---QQSSYTFDVKATDGGQPPRSSTAKV 661
Query: 293 EIELLDLNDNLPEFEVDFYNISI----VENLPNGFSVLQVMATDKDQGENGEFTYQL--D 346
I ++D+NDN P N S + +P G V +V A D D G N E Y +
Sbjct: 662 TINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELKYTIVSG 720
Query: 347 DPKGAFSIDPRSGWLTVRNQ 366
+ KG F IDP +G +T+ +
Sbjct: 721 NNKGLFRIDPVTGNITLEEK 740
Score = 59.3 bits (137), Expect = 1e-07
Identities = 47/151 (31%), Positives = 74/151 (49%), Gaps = 10/151 (6%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
S V + ++D NDN+PV + PSN + +A G+V+ +V AVD D G N + Y
Sbjct: 657 STAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYT 716
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVT 556
+ +N + F+I+P TG +++ E P G H L V SD + ++L +V
Sbjct: 717 IVSGNNKGL---FRIDPVTGNITLEEKPAPTDVGLHRLVVNISD--LGYPKSLHTLVLVF 771
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVG 587
+ V T GN I D + E + N+G
Sbjct: 772 LYV-NDTAGNASYIYDLIRRTMETPLDRNIG 801
Score = 33.1 bits (72), Expect = 7.9
Identities = 19/46 (41%), Positives = 28/46 (60%), Gaps = 4/46 (8%)
Query: 1441 ATDSDIGINADIRYQILNEQAPR----FAIDPVSGTVRVVAALARD 1482
ATD+DIG NA+IRY + AP FA++ +G + V +L R+
Sbjct: 276 ATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDRE 321
>AL355173-2|CAH72612.1| 1203|Homo sapiens protocadherin 9 protein.
Length = 1203
Score = 142 bits (345), Expect = 7e-33
Identities = 167/629 (26%), Positives = 276/629 (43%), Gaps = 82/629 (13%)
Query: 738 IFTQKPLDREKRDVYRMTV-IAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFI 796
+ Q+ LDRE++D Y M + + + S I QVT+ D NDN PVF+ E I
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV--SDVNDNRPVFKEGQVEVHI 261
Query: 797 MENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG-----KEMFDVDENTGVVKFIGD 851
EN+ +GT + + ATDAD G+NA Y +FG K +F ++ TG++ +
Sbjct: 262 PENAPVGTSVIQ---LHATDADIGSNAEIRY-IFGAQVAPATKRLFALNNTTGLIT-VQR 316
Query: 852 SLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
SLDRE+ ++K++++A D G S+ A + I N + N N +R + + +N
Sbjct: 317 SLDREETAIHKVTVLASD--GSSTPARATVTI-----NVTDVNDNPPNIDLR-YIISPIN 368
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
GT + E P+ T I + D D+ +NG++
Sbjct: 369 GTV------------------------YLSEKDPVNTKIALITVSDKDTDVNGKVICFIE 404
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGG--NLNDNI 1029
EV P L A + +Y + EF I A D G +LN
Sbjct: 405 REV---PFHLKA--VYDNQYLLETSS------LLDYEGTKEFSFKIVASDSGKPSLNQTA 453
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
VRV ++D ND+ P+F + +V E L + ATD D G+NA++ Y + P+ +
Sbjct: 454 LVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS 513
Query: 1090 DLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
F++ TGVL+ + DRE ++++I TV ARDNG D NDNSP
Sbjct: 514 F--FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVL-DENDNSP 570
Query: 1150 KFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGN 1209
KF ++ ++ L ++ +V +I V A EN + T++ + ND +
Sbjct: 571 KFTHN----HFQFFVSENLPKYS--TVGVITVTDADAGENKAV--TLSILNDNDNFVLDP 622
Query: 1210 GNGLILYSLPQRKNQQNL----------GLPSLSSTAILMVTVADVPDEVEMSDKPVFIS 1259
+G+I ++ + QQ+ G P SSTA + + V DV D + P +
Sbjct: 623 YSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNT 682
Query: 1260 RYYELEIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVR 1319
+ + + + V V + N +++Y I++ N+ + F IDP G + L
Sbjct: 683 SFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGL---FRIDPVTGNITLEE 739
Query: 1320 SPDREVKDTYEVIVRAERQKYSRELPHMI 1348
P + ++V Y + L ++
Sbjct: 740 KPAPTDVGLHRLVVNISDLGYPKSLHTLV 768
Score = 125 bits (301), Expect = 1e-27
Identities = 176/674 (26%), Positives = 278/674 (41%), Gaps = 60/674 (8%)
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGF-SVLQVMATDKD 334
V+ S + T R++ E L + E F+ + +V LPN F ++++ KD
Sbjct: 76 VKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVI-LPNDFFRLIKIKIIVKD 134
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLR-MKVYAKETNPSVVGT 393
+N P SI P + + R + + ++ Y SV G
Sbjct: 135 TNDNAPM---FPSPVINISI-PENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGL 190
Query: 394 -FADSQRIAKWRRQPLETNAPLE-KTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLD 451
++ KW + ++ N E K TYV KV + Q S ++VT+ D
Sbjct: 191 DIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVE------DGGTPQKSSTAILQVTVSD 244
Query: 452 ANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPF 511
NDN PVF + E + NA VGT + ++ A D D+G N + Y F
Sbjct: 245 VNDNRPVFKEGQV-EVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLF 303
Query: 512 KINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPD 569
+N TG ++V S E H + V ASD + P+ A VTI VT N P+
Sbjct: 304 ALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPAR-----ATVTINVT-DVNDNPPN 357
Query: 570 IP-DFMGAPYE--FWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF---AVE 623
I ++ +P ++ + T + I V+D + DV+ ++ E VPF AV
Sbjct: 358 IDLRYIISPINGTVYLSEKDPVNTKIALITVSD--KDTDVNGKVICFIEREVPFHLKAVY 415
Query: 624 ERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLLKGAHS 682
+ ++ L + F+ VA +L+ V + D ND + +
Sbjct: 416 DNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF----NQ 471
Query: 683 PII-FHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
P+I V EN+ G + I T+ S G V L N D + G +
Sbjct: 472 PVIELSVSENNRRGLYLTTISATDEDS--GKNADIVYQLGPNASFFDLD---RKTGVLTA 526
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
+ DRE+++ + TV A N G V + + DENDN P F H ++ F+ EN
Sbjct: 527 SRVFDREEQERFIFTVTARDN-GTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL 585
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIM 860
+ + +I TDAD G N ++ + + F +D +GV+K S DRE++
Sbjct: 586 PKYSTV---GVITVTDADAGENKAVTLSILND-NDNFVLDPYSGVIK-SNVSFDREQQSS 640
Query: 861 YKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTI 918
Y + A D G SS A++ I + D NDN P N+ ++ L+ G +
Sbjct: 641 YTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKL---VPLSAIPGSVV 697
Query: 919 IEVKPKNKFALDVD 932
EV FA+DVD
Sbjct: 698 AEV-----FAVDVD 706
Score = 83.0 bits (196), Expect = 7e-15
Identities = 116/467 (24%), Positives = 190/467 (40%), Gaps = 63/467 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN I + +A D D+G NG YE + S D +E E+
Sbjct: 151 IPENTLINSRFPIPSATDPDTGFNGVQHYELLNG----QSVFGLDIVETPE----GEKWP 202
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNIS--VRVFVKDVNDHFPVFKKTWYNFNVE 1055
+IV ++L E + + + I DGG + + ++V V DVND+ PVFK+ ++
Sbjct: 203 QLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIP 262
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYF----IQPSDTDLPFEISPLTGVLSVNGELDRE 1111
E + ++ ATDAD G NA + Y + P+ L F ++ TG+++V LDRE
Sbjct: 263 ENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FALNNTTGLITVQRSLDRE 321
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF---YAFDELLEWKHPEADEL 1168
+ +TV+A D DVNDN P Y + + +
Sbjct: 322 ETAIHKVTVLASDG---SSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDP 378
Query: 1169 SNHNFESVMMIPVYKATIEENAPIGTTVAKVF------ANDTDFIGNGNGLILYSLPQRK 1222
N + +I V + N + + + D ++ + L+ Y +
Sbjct: 379 VN---TKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEF 435
Query: 1223 N----QQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVS 1278
+ + G PSL+ TA++ V + D E + P+F EL + EN + L +
Sbjct: 436 SFKIVASDSGKPSLNQTALVRVKLED-----ENDNPPIFNQPVIELSVSENNRRGLYLTT 490
Query: 1279 LNLTEHYENFKMR-YYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAER 1337
++ T+ Y L N + F +D + G L R DRE ++ + V A R
Sbjct: 491 ISATDEDSGKNADIVYQLGPNAS----FFDLDRKTGVLTASRVFDREEQERFIFTVTA-R 545
Query: 1338 QKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGN 1384
+ L + V+V + D NDNSPKFT+ +
Sbjct: 546 DNGTPPL----------------QSQAAVIVTVLDENDNSPKFTHNH 576
Score = 80.6 bits (190), Expect = 4e-14
Identities = 58/188 (30%), Positives = 85/188 (45%), Gaps = 9/188 (4%)
Query: 198 QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEK 257
Q VI S ++ L+ I A D+D G A + Y+L G + F LD G L +
Sbjct: 471 QPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASR 528
Query: 258 ELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVE 317
D + + F+ V A P +QA V + +LD NDN P+F + + + E
Sbjct: 529 VFDREEQER-----FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSE 583
Query: 318 NLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSL 377
NLP +V + TD D GEN T + + F +DP SG +++ DRE SS
Sbjct: 584 NLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSG--VIKSNVSFDREQQSSY 641
Query: 378 RMKVYAKE 385
V A +
Sbjct: 642 TFDVKATD 649
Score = 79.4 bits (187), Expect = 9e-14
Identities = 60/180 (33%), Positives = 91/180 (50%), Gaps = 14/180 (7%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNL---QAN 270
FP P A D D G YEL++G + +F LD V EK L + NL Q +
Sbjct: 161 FPIP-SATDPDTGFNGVQHYELLNG--QSVFGLDIVETPEG-EKWPQLIVQQNLDREQKD 216
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
T+V++++ P K++ A +++ + D+NDN P F+ + I EN P G SV+Q+ A
Sbjct: 217 TYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHA 276
Query: 331 TDKDQGENGEFTY-----QLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TD D G N E Y K F+++ +G +TV Q LDRE + ++ V A +
Sbjct: 277 TDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITV--QRSLDREETAIHKVTVLASD 334
Score = 64.5 bits (150), Expect = 3e-09
Identities = 68/270 (25%), Positives = 116/270 (42%), Gaps = 24/270 (8%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V L D NDN P+F + E S+ N + G + + A D D G+N ++Y L ++
Sbjct: 455 VRVKLEDENDNPPIF-NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS 513
Query: 505 LTITSPFKINPNTG--TVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F ++ TG T S + R V A D P + + ++ V ++
Sbjct: 514 F-----FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLD---- 564
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN--DAFEQNDVSYDLLHGYEEGVPF 620
+ P F ++F+V N+ ++VG I V DA E V+ +L+ + F
Sbjct: 565 ---ENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---F 618
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTNATVHVVDVNDERGVLLKG 679
++ SGVI R + Y F+ A S T++V+DVND V++
Sbjct: 619 VLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVI-S 677
Query: 680 AHSPIIFHVKENSA--GAAIGQIFHTNMSS 707
S F + SA G+ + ++F ++ +
Sbjct: 678 PPSNTSFKLVPLSAIPGSVVAEVFAVDVDT 707
Score = 63.7 bits (148), Expect = 5e-09
Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 2/114 (1%)
Query: 272 FVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMAT 331
F ++ AS P A V ++L D NDN P F +S+ EN G + + AT
Sbjct: 435 FSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISAT 494
Query: 332 DKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D+D G+N + YQL F +D ++G LT V DRE V A++
Sbjct: 495 DEDSGKNADIVYQLGPNASFFDLDRKTGVLTA--SRVFDREEQERFIFTVTARD 546
Score = 62.9 bits (146), Expect = 9e-09
Identities = 99/390 (25%), Positives = 155/390 (39%), Gaps = 62/390 (15%)
Query: 940 IPENIPIGTTIIKLNALDLDS--GLNGQIRYEFNSEVYIPPS-KLSADALEVKRYFVINE 996
+PEN+PIG LN +++ G + + Y S+ P K+S+ E+ F +
Sbjct: 34 LPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEI---FTTSN 90
Query: 997 R--HGHVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
R + S E+E F L + L I +++ VKD ND+ P+F N
Sbjct: 91 RIDREKLCAGASYAEENECFFELEVVILPNDFFR-LIKIKIIVKDTNDNAPMFPSPVINI 149
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGE 1107
++ E ATD D G N Y + + +I L V
Sbjct: 150 SIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQN 209
Query: 1108 LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE 1167
LDRE +D Y++ + D G DVNDN P F + +
Sbjct: 210 LDREQKDTYVMKIKVEDGG-TPQKSSTAILQVTVSDVNDNRPVF------------KEGQ 256
Query: 1168 LSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL 1227
+ H IP ENAP+GT+V ++ A D D IG+ N I Y +
Sbjct: 257 VEVH-------IP-------ENAPVGTSVIQLHATDAD-IGS-NAEIRYIFGAQVAPATK 300
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN 1287
L +L++T L +TV D E + I + L + + V++N+T+
Sbjct: 301 RLFALNNTTGL-ITVQRSLDREETA-----IHKVTVLASDGSSTPARATVTINVTD---- 350
Query: 1288 FKMRYYILNENDTDIRRTFVIDPRNGTLYL 1317
+N+N +I ++I P NGT+YL
Sbjct: 351 -------VNDNPPNIDLRYIISPINGTVYL 373
Score = 59.7 bits (138), Expect = 8e-08
Identities = 76/320 (23%), Positives = 135/320 (42%), Gaps = 38/320 (11%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE----------LTPTGEKA 116
+V +G ++ V V +ED NDN PIF ++V E ++ T E +
Sbjct: 439 IVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDS 498
Query: 117 F--IFLIAPIGPSLTIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFAL 174
++ +GP+ + + R + R FDR++ + V+ D+G L
Sbjct: 499 GKNADIVYQLGPNASF-FDLDRKTGVLTASRVFDREE-----QERFIFTVTARDNGTPPL 552
Query: 175 ESSHKPVLLLRKVLDYDAG--DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLR 232
+S ++ + D FQ + + + + I D D G +
Sbjct: 553 QSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV----ITVTDADAGENKAVT 608
Query: 233 YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV 292
+++ ND F LD +G ++ + D E Q +++ V+A+ P +++ A+V
Sbjct: 609 LSILNDNDN--FVLDPYSG--VIKSNVSFDRE---QQSSYTFDVKATDGGQPPRSSTAKV 661
Query: 293 EIELLDLNDNLPEFEVDFYNISI----VENLPNGFSVLQVMATDKDQGENGEFTYQL--D 346
I ++D+NDN P N S + +P G V +V A D D G N E Y +
Sbjct: 662 TINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELKYTIVSG 720
Query: 347 DPKGAFSIDPRSGWLTVRNQ 366
+ KG F IDP +G +T+ +
Sbjct: 721 NNKGLFRIDPVTGNITLEEK 740
Score = 59.3 bits (137), Expect = 1e-07
Identities = 47/151 (31%), Positives = 74/151 (49%), Gaps = 10/151 (6%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
S V + ++D NDN+PV + PSN + +A G+V+ +V AVD D G N + Y
Sbjct: 657 STAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYT 716
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVT 556
+ +N + F+I+P TG +++ E P G H L V SD + ++L +V
Sbjct: 717 IVSGNNKGL---FRIDPVTGNITLEEKPAPTDVGLHRLVVNISD--LGYPKSLHTLVLVF 771
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVG 587
+ V T GN I D + E + N+G
Sbjct: 772 LYV-NDTAGNASYIYDLIRRTMETPLDRNIG 801
Score = 33.1 bits (72), Expect = 7.9
Identities = 19/46 (41%), Positives = 28/46 (60%), Gaps = 4/46 (8%)
Query: 1441 ATDSDIGINADIRYQILNEQAPR----FAIDPVSGTVRVVAALARD 1482
ATD+DIG NA+IRY + AP FA++ +G + V +L R+
Sbjct: 276 ATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDRE 321
>AL355173-1|CAM17290.1| 1237|Homo sapiens protocadherin 9 protein.
Length = 1237
Score = 142 bits (345), Expect = 7e-33
Identities = 167/629 (26%), Positives = 276/629 (43%), Gaps = 82/629 (13%)
Query: 738 IFTQKPLDREKRDVYRMTV-IAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFI 796
+ Q+ LDRE++D Y M + + + S I QVT+ D NDN PVF+ E I
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV--SDVNDNRPVFKEGQVEVHI 261
Query: 797 MENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG-----KEMFDVDENTGVVKFIGD 851
EN+ +GT + + ATDAD G+NA Y +FG K +F ++ TG++ +
Sbjct: 262 PENAPVGTSVIQ---LHATDADIGSNAEIRY-IFGAQVAPATKRLFALNNTTGLIT-VQR 316
Query: 852 SLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
SLDRE+ ++K++++A D G S+ A + I N + N N +R + + +N
Sbjct: 317 SLDREETAIHKVTVLASD--GSSTPARATVTI-----NVTDVNDNPPNIDLR-YIISPIN 368
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
GT + E P+ T I + D D+ +NG++
Sbjct: 369 GTV------------------------YLSEKDPVNTKIALITVSDKDTDVNGKVICFIE 404
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGG--NLNDNI 1029
EV P L A + +Y + EF I A D G +LN
Sbjct: 405 REV---PFHLKA--VYDNQYLLETSS------LLDYEGTKEFSFKIVASDSGKPSLNQTA 453
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
VRV ++D ND+ P+F + +V E L + ATD D G+NA++ Y + P+ +
Sbjct: 454 LVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS 513
Query: 1090 DLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
F++ TGVL+ + DRE ++++I TV ARDNG D NDNSP
Sbjct: 514 F--FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVL-DENDNSP 570
Query: 1150 KFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGN 1209
KF ++ ++ L ++ +V +I V A EN + T++ + ND +
Sbjct: 571 KFTHN----HFQFFVSENLPKYS--TVGVITVTDADAGENKAV--TLSILNDNDNFVLDP 622
Query: 1210 GNGLILYSLPQRKNQQNL----------GLPSLSSTAILMVTVADVPDEVEMSDKPVFIS 1259
+G+I ++ + QQ+ G P SSTA + + V DV D + P +
Sbjct: 623 YSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNT 682
Query: 1260 RYYELEIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVR 1319
+ + + + V V + N +++Y I++ N+ + F IDP G + L
Sbjct: 683 SFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGL---FRIDPVTGNITLEE 739
Query: 1320 SPDREVKDTYEVIVRAERQKYSRELPHMI 1348
P + ++V Y + L ++
Sbjct: 740 KPAPTDVGLHRLVVNISDLGYPKSLHTLV 768
Score = 125 bits (301), Expect = 1e-27
Identities = 176/674 (26%), Positives = 278/674 (41%), Gaps = 60/674 (8%)
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGF-SVLQVMATDKD 334
V+ S + T R++ E L + E F+ + +V LPN F ++++ KD
Sbjct: 76 VKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVI-LPNDFFRLIKIKIIVKD 134
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLR-MKVYAKETNPSVVGT 393
+N P SI P + + R + + ++ Y SV G
Sbjct: 135 TNDNAPM---FPSPVINISI-PENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGL 190
Query: 394 -FADSQRIAKWRRQPLETNAPLE-KTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLD 451
++ KW + ++ N E K TYV KV + Q S ++VT+ D
Sbjct: 191 DIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVE------DGGTPQKSSTAILQVTVSD 244
Query: 452 ANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPF 511
NDN PVF + E + NA VGT + ++ A D D+G N + Y F
Sbjct: 245 VNDNRPVFKEGQV-EVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLF 303
Query: 512 KINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPD 569
+N TG ++V S E H + V ASD + P+ A VTI VT N P+
Sbjct: 304 ALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPAR-----ATVTINVT-DVNDNPPN 357
Query: 570 IP-DFMGAPYE--FWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF---AVE 623
I ++ +P ++ + T + I V+D + DV+ ++ E VPF AV
Sbjct: 358 IDLRYIISPINGTVYLSEKDPVNTKIALITVSD--KDTDVNGKVICFIEREVPFHLKAVY 415
Query: 624 ERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLLKGAHS 682
+ ++ L + F+ VA +L+ V + D ND + +
Sbjct: 416 DNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF----NQ 471
Query: 683 PII-FHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
P+I V EN+ G + I T+ S G V L N D + G +
Sbjct: 472 PVIELSVSENNRRGLYLTTISATDEDS--GKNADIVYQLGPNASFFDLD---RKTGVLTA 526
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
+ DRE+++ + TV A N G V + + DENDN P F H ++ F+ EN
Sbjct: 527 SRVFDREEQERFIFTVTARDN-GTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL 585
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIM 860
+ + +I TDAD G N ++ + + F +D +GV+K S DRE++
Sbjct: 586 PKYSTV---GVITVTDADAGENKAVTLSILND-NDNFVLDPYSGVIK-SNVSFDREQQSS 640
Query: 861 YKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTI 918
Y + A D G SS A++ I + D NDN P N+ ++ L+ G +
Sbjct: 641 YTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKL---VPLSAIPGSVV 697
Query: 919 IEVKPKNKFALDVD 932
EV FA+DVD
Sbjct: 698 AEV-----FAVDVD 706
Score = 83.0 bits (196), Expect = 7e-15
Identities = 116/467 (24%), Positives = 190/467 (40%), Gaps = 63/467 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN I + +A D D+G NG YE + S D +E E+
Sbjct: 151 IPENTLINSRFPIPSATDPDTGFNGVQHYELLNG----QSVFGLDIVETPE----GEKWP 202
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNIS--VRVFVKDVNDHFPVFKKTWYNFNVE 1055
+IV ++L E + + + I DGG + + ++V V DVND+ PVFK+ ++
Sbjct: 203 QLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIP 262
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYF----IQPSDTDLPFEISPLTGVLSVNGELDRE 1111
E + ++ ATDAD G NA + Y + P+ L F ++ TG+++V LDRE
Sbjct: 263 ENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FALNNTTGLITVQRSLDRE 321
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF---YAFDELLEWKHPEADEL 1168
+ +TV+A D DVNDN P Y + + +
Sbjct: 322 ETAIHKVTVLASDG---SSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDP 378
Query: 1169 SNHNFESVMMIPVYKATIEENAPIGTTVAKVF------ANDTDFIGNGNGLILYSLPQRK 1222
N + +I V + N + + + D ++ + L+ Y +
Sbjct: 379 VN---TKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEF 435
Query: 1223 N----QQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVS 1278
+ + G PSL+ TA++ V + D E + P+F EL + EN + L +
Sbjct: 436 SFKIVASDSGKPSLNQTALVRVKLED-----ENDNPPIFNQPVIELSVSENNRRGLYLTT 490
Query: 1279 LNLTEHYENFKMR-YYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAER 1337
++ T+ Y L N + F +D + G L R DRE ++ + V A R
Sbjct: 491 ISATDEDSGKNADIVYQLGPNAS----FFDLDRKTGVLTASRVFDREEQERFIFTVTA-R 545
Query: 1338 QKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGN 1384
+ L + V+V + D NDNSPKFT+ +
Sbjct: 546 DNGTPPL----------------QSQAAVIVTVLDENDNSPKFTHNH 576
Score = 80.6 bits (190), Expect = 4e-14
Identities = 58/188 (30%), Positives = 85/188 (45%), Gaps = 9/188 (4%)
Query: 198 QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEK 257
Q VI S ++ L+ I A D+D G A + Y+L G + F LD G L +
Sbjct: 471 QPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASR 528
Query: 258 ELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVE 317
D + + F+ V A P +QA V + +LD NDN P+F + + + E
Sbjct: 529 VFDREEQER-----FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSE 583
Query: 318 NLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSL 377
NLP +V + TD D GEN T + + F +DP SG +++ DRE SS
Sbjct: 584 NLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSG--VIKSNVSFDREQQSSY 641
Query: 378 RMKVYAKE 385
V A +
Sbjct: 642 TFDVKATD 649
Score = 79.4 bits (187), Expect = 9e-14
Identities = 60/180 (33%), Positives = 91/180 (50%), Gaps = 14/180 (7%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNL---QAN 270
FP P A D D G YEL++G + +F LD V EK L + NL Q +
Sbjct: 161 FPIP-SATDPDTGFNGVQHYELLNG--QSVFGLDIVETPEG-EKWPQLIVQQNLDREQKD 216
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
T+V++++ P K++ A +++ + D+NDN P F+ + I EN P G SV+Q+ A
Sbjct: 217 TYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHA 276
Query: 331 TDKDQGENGEFTY-----QLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TD D G N E Y K F+++ +G +TV Q LDRE + ++ V A +
Sbjct: 277 TDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITV--QRSLDREETAIHKVTVLASD 334
Score = 64.5 bits (150), Expect = 3e-09
Identities = 68/270 (25%), Positives = 116/270 (42%), Gaps = 24/270 (8%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V L D NDN P+F + E S+ N + G + + A D D G+N ++Y L ++
Sbjct: 455 VRVKLEDENDNPPIF-NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS 513
Query: 505 LTITSPFKINPNTG--TVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F ++ TG T S + R V A D P + + ++ V ++
Sbjct: 514 F-----FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLD---- 564
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN--DAFEQNDVSYDLLHGYEEGVPF 620
+ P F ++F+V N+ ++VG I V DA E V+ +L+ + F
Sbjct: 565 ---ENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---F 618
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTNATVHVVDVNDERGVLLKG 679
++ SGVI R + Y F+ A S T++V+DVND V++
Sbjct: 619 VLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVI-S 677
Query: 680 AHSPIIFHVKENSA--GAAIGQIFHTNMSS 707
S F + SA G+ + ++F ++ +
Sbjct: 678 PPSNTSFKLVPLSAIPGSVVAEVFAVDVDT 707
Score = 63.7 bits (148), Expect = 5e-09
Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 2/114 (1%)
Query: 272 FVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMAT 331
F ++ AS P A V ++L D NDN P F +S+ EN G + + AT
Sbjct: 435 FSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISAT 494
Query: 332 DKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D+D G+N + YQL F +D ++G LT V DRE V A++
Sbjct: 495 DEDSGKNADIVYQLGPNASFFDLDRKTGVLTA--SRVFDREEQERFIFTVTARD 546
Score = 62.9 bits (146), Expect = 9e-09
Identities = 99/390 (25%), Positives = 155/390 (39%), Gaps = 62/390 (15%)
Query: 940 IPENIPIGTTIIKLNALDLDS--GLNGQIRYEFNSEVYIPPS-KLSADALEVKRYFVINE 996
+PEN+PIG LN +++ G + + Y S+ P K+S+ E+ F +
Sbjct: 34 LPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEI---FTTSN 90
Query: 997 R--HGHVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
R + S E+E F L + L I +++ VKD ND+ P+F N
Sbjct: 91 RIDREKLCAGASYAEENECFFELEVVILPNDFFR-LIKIKIIVKDTNDNAPMFPSPVINI 149
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGE 1107
++ E ATD D G N Y + + +I L V
Sbjct: 150 SIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQN 209
Query: 1108 LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE 1167
LDRE +D Y++ + D G DVNDN P F + +
Sbjct: 210 LDREQKDTYVMKIKVEDGG-TPQKSSTAILQVTVSDVNDNRPVF------------KEGQ 256
Query: 1168 LSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL 1227
+ H IP ENAP+GT+V ++ A D D IG+ N I Y +
Sbjct: 257 VEVH-------IP-------ENAPVGTSVIQLHATDAD-IGS-NAEIRYIFGAQVAPATK 300
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN 1287
L +L++T L +TV D E + I + L + + V++N+T+
Sbjct: 301 RLFALNNTTGL-ITVQRSLDREETA-----IHKVTVLASDGSSTPARATVTINVTD---- 350
Query: 1288 FKMRYYILNENDTDIRRTFVIDPRNGTLYL 1317
+N+N +I ++I P NGT+YL
Sbjct: 351 -------VNDNPPNIDLRYIISPINGTVYL 373
Score = 59.7 bits (138), Expect = 8e-08
Identities = 76/320 (23%), Positives = 135/320 (42%), Gaps = 38/320 (11%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE----------LTPTGEKA 116
+V +G ++ V V +ED NDN PIF ++V E ++ T E +
Sbjct: 439 IVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDS 498
Query: 117 F--IFLIAPIGPSLTIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFAL 174
++ +GP+ + + R + R FDR++ + V+ D+G L
Sbjct: 499 GKNADIVYQLGPNASF-FDLDRKTGVLTASRVFDREE-----QERFIFTVTARDNGTPPL 552
Query: 175 ESSHKPVLLLRKVLDYDAG--DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLR 232
+S ++ + D FQ + + + + I D D G +
Sbjct: 553 QSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV----ITVTDADAGENKAVT 608
Query: 233 YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV 292
+++ ND F LD +G ++ + D E Q +++ V+A+ P +++ A+V
Sbjct: 609 LSILNDNDN--FVLDPYSG--VIKSNVSFDRE---QQSSYTFDVKATDGGQPPRSSTAKV 661
Query: 293 EIELLDLNDNLPEFEVDFYNISI----VENLPNGFSVLQVMATDKDQGENGEFTYQL--D 346
I ++D+NDN P N S + +P G V +V A D D G N E Y +
Sbjct: 662 TINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELKYTIVSG 720
Query: 347 DPKGAFSIDPRSGWLTVRNQ 366
+ KG F IDP +G +T+ +
Sbjct: 721 NNKGLFRIDPVTGNITLEEK 740
Score = 59.3 bits (137), Expect = 1e-07
Identities = 47/151 (31%), Positives = 74/151 (49%), Gaps = 10/151 (6%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
S V + ++D NDN+PV + PSN + +A G+V+ +V AVD D G N + Y
Sbjct: 657 STAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYT 716
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVT 556
+ +N + F+I+P TG +++ E P G H L V SD + ++L +V
Sbjct: 717 IVSGNNKGL---FRIDPVTGNITLEEKPAPTDVGLHRLVVNISD--LGYPKSLHTLVLVF 771
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVG 587
+ V T GN I D + E + N+G
Sbjct: 772 LYV-NDTAGNASYIYDLIRRTMETPLDRNIG 801
Score = 33.1 bits (72), Expect = 7.9
Identities = 19/46 (41%), Positives = 28/46 (60%), Gaps = 4/46 (8%)
Query: 1441 ATDSDIGINADIRYQILNEQAPR----FAIDPVSGTVRVVAALARD 1482
ATD+DIG NA+IRY + AP FA++ +G + V +L R+
Sbjct: 276 ATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDRE 321
>AL138814-1|CAM13066.1| 1237|Homo sapiens protocadherin 9 protein.
Length = 1237
Score = 142 bits (345), Expect = 7e-33
Identities = 167/629 (26%), Positives = 276/629 (43%), Gaps = 82/629 (13%)
Query: 738 IFTQKPLDREKRDVYRMTV-IAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFI 796
+ Q+ LDRE++D Y M + + + S I QVT+ D NDN PVF+ E I
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV--SDVNDNRPVFKEGQVEVHI 261
Query: 797 MENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG-----KEMFDVDENTGVVKFIGD 851
EN+ +GT + + ATDAD G+NA Y +FG K +F ++ TG++ +
Sbjct: 262 PENAPVGTSVIQ---LHATDADIGSNAEIRY-IFGAQVAPATKRLFALNNTTGLIT-VQR 316
Query: 852 SLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
SLDRE+ ++K++++A D G S+ A + I N + N N +R + + +N
Sbjct: 317 SLDREETAIHKVTVLASD--GSSTPARATVTI-----NVTDVNDNPPNIDLR-YIISPIN 368
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
GT + E P+ T I + D D+ +NG++
Sbjct: 369 GTV------------------------YLSEKDPVNTKIALITVSDKDTDVNGKVICFIE 404
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGG--NLNDNI 1029
EV P L A + +Y + EF I A D G +LN
Sbjct: 405 REV---PFHLKA--VYDNQYLLETSS------LLDYEGTKEFSFKIVASDSGKPSLNQTA 453
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
VRV ++D ND+ P+F + +V E L + ATD D G+NA++ Y + P+ +
Sbjct: 454 LVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS 513
Query: 1090 DLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
F++ TGVL+ + DRE ++++I TV ARDNG D NDNSP
Sbjct: 514 F--FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVL-DENDNSP 570
Query: 1150 KFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGN 1209
KF ++ ++ L ++ +V +I V A EN + T++ + ND +
Sbjct: 571 KFTHN----HFQFFVSENLPKYS--TVGVITVTDADAGENKAV--TLSILNDNDNFVLDP 622
Query: 1210 GNGLILYSLPQRKNQQNL----------GLPSLSSTAILMVTVADVPDEVEMSDKPVFIS 1259
+G+I ++ + QQ+ G P SSTA + + V DV D + P +
Sbjct: 623 YSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNT 682
Query: 1260 RYYELEIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVR 1319
+ + + + V V + N +++Y I++ N+ + F IDP G + L
Sbjct: 683 SFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGL---FRIDPVTGNITLEE 739
Query: 1320 SPDREVKDTYEVIVRAERQKYSRELPHMI 1348
P + ++V Y + L ++
Sbjct: 740 KPAPTDVGLHRLVVNISDLGYPKSLHTLV 768
Score = 125 bits (301), Expect = 1e-27
Identities = 176/674 (26%), Positives = 278/674 (41%), Gaps = 60/674 (8%)
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGF-SVLQVMATDKD 334
V+ S + T R++ E L + E F+ + +V LPN F ++++ KD
Sbjct: 76 VKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVI-LPNDFFRLIKIKIIVKD 134
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLR-MKVYAKETNPSVVGT 393
+N P SI P + + R + + ++ Y SV G
Sbjct: 135 TNDNAPM---FPSPVINISI-PENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGL 190
Query: 394 -FADSQRIAKWRRQPLETNAPLE-KTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLD 451
++ KW + ++ N E K TYV KV + Q S ++VT+ D
Sbjct: 191 DIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVE------DGGTPQKSSTAILQVTVSD 244
Query: 452 ANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPF 511
NDN PVF + E + NA VGT + ++ A D D+G N + Y F
Sbjct: 245 VNDNRPVFKEGQV-EVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLF 303
Query: 512 KINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPD 569
+N TG ++V S E H + V ASD + P+ A VTI VT N P+
Sbjct: 304 ALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPAR-----ATVTINVT-DVNDNPPN 357
Query: 570 IP-DFMGAPYE--FWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF---AVE 623
I ++ +P ++ + T + I V+D + DV+ ++ E VPF AV
Sbjct: 358 IDLRYIISPINGTVYLSEKDPVNTKIALITVSD--KDTDVNGKVICFIEREVPFHLKAVY 415
Query: 624 ERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLLKGAHS 682
+ ++ L + F+ VA +L+ V + D ND + +
Sbjct: 416 DNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF----NQ 471
Query: 683 PII-FHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
P+I V EN+ G + I T+ S G V L N D + G +
Sbjct: 472 PVIELSVSENNRRGLYLTTISATDEDS--GKNADIVYQLGPNASFFDLD---RKTGVLTA 526
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
+ DRE+++ + TV A N G V + + DENDN P F H ++ F+ EN
Sbjct: 527 SRVFDREEQERFIFTVTARDN-GTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL 585
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIM 860
+ + +I TDAD G N ++ + + F +D +GV+K S DRE++
Sbjct: 586 PKYSTV---GVITVTDADAGENKAVTLSILND-NDNFVLDPYSGVIK-SNVSFDREQQSS 640
Query: 861 YKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTI 918
Y + A D G SS A++ I + D NDN P N+ ++ L+ G +
Sbjct: 641 YTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKL---VPLSAIPGSVV 697
Query: 919 IEVKPKNKFALDVD 932
EV FA+DVD
Sbjct: 698 AEV-----FAVDVD 706
Score = 83.0 bits (196), Expect = 7e-15
Identities = 116/467 (24%), Positives = 190/467 (40%), Gaps = 63/467 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN I + +A D D+G NG YE + S D +E E+
Sbjct: 151 IPENTLINSRFPIPSATDPDTGFNGVQHYELLNG----QSVFGLDIVETPE----GEKWP 202
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNIS--VRVFVKDVNDHFPVFKKTWYNFNVE 1055
+IV ++L E + + + I DGG + + ++V V DVND+ PVFK+ ++
Sbjct: 203 QLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIP 262
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYF----IQPSDTDLPFEISPLTGVLSVNGELDRE 1111
E + ++ ATDAD G NA + Y + P+ L F ++ TG+++V LDRE
Sbjct: 263 ENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FALNNTTGLITVQRSLDRE 321
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF---YAFDELLEWKHPEADEL 1168
+ +TV+A D DVNDN P Y + + +
Sbjct: 322 ETAIHKVTVLASDG---SSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDP 378
Query: 1169 SNHNFESVMMIPVYKATIEENAPIGTTVAKVF------ANDTDFIGNGNGLILYSLPQRK 1222
N + +I V + N + + + D ++ + L+ Y +
Sbjct: 379 VN---TKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEF 435
Query: 1223 N----QQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVS 1278
+ + G PSL+ TA++ V + D E + P+F EL + EN + L +
Sbjct: 436 SFKIVASDSGKPSLNQTALVRVKLED-----ENDNPPIFNQPVIELSVSENNRRGLYLTT 490
Query: 1279 LNLTEHYENFKMR-YYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAER 1337
++ T+ Y L N + F +D + G L R DRE ++ + V A R
Sbjct: 491 ISATDEDSGKNADIVYQLGPNAS----FFDLDRKTGVLTASRVFDREEQERFIFTVTA-R 545
Query: 1338 QKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGN 1384
+ L + V+V + D NDNSPKFT+ +
Sbjct: 546 DNGTPPL----------------QSQAAVIVTVLDENDNSPKFTHNH 576
Score = 80.6 bits (190), Expect = 4e-14
Identities = 58/188 (30%), Positives = 85/188 (45%), Gaps = 9/188 (4%)
Query: 198 QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEK 257
Q VI S ++ L+ I A D+D G A + Y+L G + F LD G L +
Sbjct: 471 QPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASR 528
Query: 258 ELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVE 317
D + + F+ V A P +QA V + +LD NDN P+F + + + E
Sbjct: 529 VFDREEQER-----FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSE 583
Query: 318 NLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSL 377
NLP +V + TD D GEN T + + F +DP SG +++ DRE SS
Sbjct: 584 NLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSG--VIKSNVSFDREQQSSY 641
Query: 378 RMKVYAKE 385
V A +
Sbjct: 642 TFDVKATD 649
Score = 79.4 bits (187), Expect = 9e-14
Identities = 60/180 (33%), Positives = 91/180 (50%), Gaps = 14/180 (7%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNL---QAN 270
FP P A D D G YEL++G + +F LD V EK L + NL Q +
Sbjct: 161 FPIP-SATDPDTGFNGVQHYELLNG--QSVFGLDIVETPEG-EKWPQLIVQQNLDREQKD 216
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
T+V++++ P K++ A +++ + D+NDN P F+ + I EN P G SV+Q+ A
Sbjct: 217 TYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHA 276
Query: 331 TDKDQGENGEFTY-----QLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TD D G N E Y K F+++ +G +TV Q LDRE + ++ V A +
Sbjct: 277 TDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITV--QRSLDREETAIHKVTVLASD 334
Score = 64.5 bits (150), Expect = 3e-09
Identities = 68/270 (25%), Positives = 116/270 (42%), Gaps = 24/270 (8%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V L D NDN P+F + E S+ N + G + + A D D G+N ++Y L ++
Sbjct: 455 VRVKLEDENDNPPIF-NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS 513
Query: 505 LTITSPFKINPNTG--TVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F ++ TG T S + R V A D P + + ++ V ++
Sbjct: 514 F-----FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLD---- 564
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN--DAFEQNDVSYDLLHGYEEGVPF 620
+ P F ++F+V N+ ++VG I V DA E V+ +L+ + F
Sbjct: 565 ---ENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---F 618
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTNATVHVVDVNDERGVLLKG 679
++ SGVI R + Y F+ A S T++V+DVND V++
Sbjct: 619 VLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVI-S 677
Query: 680 AHSPIIFHVKENSA--GAAIGQIFHTNMSS 707
S F + SA G+ + ++F ++ +
Sbjct: 678 PPSNTSFKLVPLSAIPGSVVAEVFAVDVDT 707
Score = 63.7 bits (148), Expect = 5e-09
Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 2/114 (1%)
Query: 272 FVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMAT 331
F ++ AS P A V ++L D NDN P F +S+ EN G + + AT
Sbjct: 435 FSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISAT 494
Query: 332 DKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D+D G+N + YQL F +D ++G LT V DRE V A++
Sbjct: 495 DEDSGKNADIVYQLGPNASFFDLDRKTGVLTA--SRVFDREEQERFIFTVTARD 546
Score = 62.9 bits (146), Expect = 9e-09
Identities = 99/390 (25%), Positives = 155/390 (39%), Gaps = 62/390 (15%)
Query: 940 IPENIPIGTTIIKLNALDLDS--GLNGQIRYEFNSEVYIPPS-KLSADALEVKRYFVINE 996
+PEN+PIG LN +++ G + + Y S+ P K+S+ E+ F +
Sbjct: 34 LPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEI---FTTSN 90
Query: 997 R--HGHVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
R + S E+E F L + L I +++ VKD ND+ P+F N
Sbjct: 91 RIDREKLCAGASYAEENECFFELEVVILPNDFFR-LIKIKIIVKDTNDNAPMFPSPVINI 149
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGE 1107
++ E ATD D G N Y + + +I L V
Sbjct: 150 SIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQN 209
Query: 1108 LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE 1167
LDRE +D Y++ + D G DVNDN P F + +
Sbjct: 210 LDREQKDTYVMKIKVEDGG-TPQKSSTAILQVTVSDVNDNRPVF------------KEGQ 256
Query: 1168 LSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL 1227
+ H IP ENAP+GT+V ++ A D D IG+ N I Y +
Sbjct: 257 VEVH-------IP-------ENAPVGTSVIQLHATDAD-IGS-NAEIRYIFGAQVAPATK 300
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN 1287
L +L++T L +TV D E + I + L + + V++N+T+
Sbjct: 301 RLFALNNTTGL-ITVQRSLDREETA-----IHKVTVLASDGSSTPARATVTINVTD---- 350
Query: 1288 FKMRYYILNENDTDIRRTFVIDPRNGTLYL 1317
+N+N +I ++I P NGT+YL
Sbjct: 351 -------VNDNPPNIDLRYIISPINGTVYL 373
Score = 59.7 bits (138), Expect = 8e-08
Identities = 76/320 (23%), Positives = 135/320 (42%), Gaps = 38/320 (11%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE----------LTPTGEKA 116
+V +G ++ V V +ED NDN PIF ++V E ++ T E +
Sbjct: 439 IVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDS 498
Query: 117 F--IFLIAPIGPSLTIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFAL 174
++ +GP+ + + R + R FDR++ + V+ D+G L
Sbjct: 499 GKNADIVYQLGPNASF-FDLDRKTGVLTASRVFDREE-----QERFIFTVTARDNGTPPL 552
Query: 175 ESSHKPVLLLRKVLDYDAG--DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLR 232
+S ++ + D FQ + + + + I D D G +
Sbjct: 553 QSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV----ITVTDADAGENKAVT 608
Query: 233 YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV 292
+++ ND F LD +G ++ + D E Q +++ V+A+ P +++ A+V
Sbjct: 609 LSILNDNDN--FVLDPYSG--VIKSNVSFDRE---QQSSYTFDVKATDGGQPPRSSTAKV 661
Query: 293 EIELLDLNDNLPEFEVDFYNISI----VENLPNGFSVLQVMATDKDQGENGEFTYQL--D 346
I ++D+NDN P N S + +P G V +V A D D G N E Y +
Sbjct: 662 TINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELKYTIVSG 720
Query: 347 DPKGAFSIDPRSGWLTVRNQ 366
+ KG F IDP +G +T+ +
Sbjct: 721 NNKGLFRIDPVTGNITLEEK 740
Score = 59.3 bits (137), Expect = 1e-07
Identities = 47/151 (31%), Positives = 74/151 (49%), Gaps = 10/151 (6%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
S V + ++D NDN+PV + PSN + +A G+V+ +V AVD D G N + Y
Sbjct: 657 STAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYT 716
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVT 556
+ +N + F+I+P TG +++ E P G H L V SD + ++L +V
Sbjct: 717 IVSGNNKGL---FRIDPVTGNITLEEKPAPTDVGLHRLVVNISD--LGYPKSLHTLVLVF 771
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVG 587
+ V T GN I D + E + N+G
Sbjct: 772 LYV-NDTAGNASYIYDLIRRTMETPLDRNIG 801
Score = 33.1 bits (72), Expect = 7.9
Identities = 19/46 (41%), Positives = 28/46 (60%), Gaps = 4/46 (8%)
Query: 1441 ATDSDIGINADIRYQILNEQAPR----FAIDPVSGTVRVVAALARD 1482
ATD+DIG NA+IRY + AP FA++ +G + V +L R+
Sbjct: 276 ATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDRE 321
>AL136999-2|CAI12502.1| 1203|Homo sapiens protocadherin 9 protein.
Length = 1203
Score = 142 bits (345), Expect = 7e-33
Identities = 167/629 (26%), Positives = 276/629 (43%), Gaps = 82/629 (13%)
Query: 738 IFTQKPLDREKRDVYRMTV-IAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFI 796
+ Q+ LDRE++D Y M + + + S I QVT+ D NDN PVF+ E I
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV--SDVNDNRPVFKEGQVEVHI 261
Query: 797 MENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG-----KEMFDVDENTGVVKFIGD 851
EN+ +GT + + ATDAD G+NA Y +FG K +F ++ TG++ +
Sbjct: 262 PENAPVGTSVIQ---LHATDADIGSNAEIRY-IFGAQVAPATKRLFALNNTTGLIT-VQR 316
Query: 852 SLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
SLDRE+ ++K++++A D G S+ A + I N + N N +R + + +N
Sbjct: 317 SLDREETAIHKVTVLASD--GSSTPARATVTI-----NVTDVNDNPPNIDLR-YIISPIN 368
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
GT + E P+ T I + D D+ +NG++
Sbjct: 369 GTV------------------------YLSEKDPVNTKIALITVSDKDTDVNGKVICFIE 404
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGG--NLNDNI 1029
EV P L A + +Y + EF I A D G +LN
Sbjct: 405 REV---PFHLKA--VYDNQYLLETSS------LLDYEGTKEFSFKIVASDSGKPSLNQTA 453
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
VRV ++D ND+ P+F + +V E L + ATD D G+NA++ Y + P+ +
Sbjct: 454 LVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS 513
Query: 1090 DLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
F++ TGVL+ + DRE ++++I TV ARDNG D NDNSP
Sbjct: 514 F--FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVL-DENDNSP 570
Query: 1150 KFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGN 1209
KF ++ ++ L ++ +V +I V A EN + T++ + ND +
Sbjct: 571 KFTHN----HFQFFVSENLPKYS--TVGVITVTDADAGENKAV--TLSILNDNDNFVLDP 622
Query: 1210 GNGLILYSLPQRKNQQNL----------GLPSLSSTAILMVTVADVPDEVEMSDKPVFIS 1259
+G+I ++ + QQ+ G P SSTA + + V DV D + P +
Sbjct: 623 YSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNT 682
Query: 1260 RYYELEIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVR 1319
+ + + + V V + N +++Y I++ N+ + F IDP G + L
Sbjct: 683 SFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGL---FRIDPVTGNITLEE 739
Query: 1320 SPDREVKDTYEVIVRAERQKYSRELPHMI 1348
P + ++V Y + L ++
Sbjct: 740 KPAPTDVGLHRLVVNISDLGYPKSLHTLV 768
Score = 125 bits (301), Expect = 1e-27
Identities = 176/674 (26%), Positives = 278/674 (41%), Gaps = 60/674 (8%)
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGF-SVLQVMATDKD 334
V+ S + T R++ E L + E F+ + +V LPN F ++++ KD
Sbjct: 76 VKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVI-LPNDFFRLIKIKIIVKD 134
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLR-MKVYAKETNPSVVGT 393
+N P SI P + + R + + ++ Y SV G
Sbjct: 135 TNDNAPM---FPSPVINISI-PENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGL 190
Query: 394 -FADSQRIAKWRRQPLETNAPLE-KTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLD 451
++ KW + ++ N E K TYV KV + Q S ++VT+ D
Sbjct: 191 DIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVE------DGGTPQKSSTAILQVTVSD 244
Query: 452 ANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPF 511
NDN PVF + E + NA VGT + ++ A D D+G N + Y F
Sbjct: 245 VNDNRPVFKEGQV-EVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLF 303
Query: 512 KINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPD 569
+N TG ++V S E H + V ASD + P+ A VTI VT N P+
Sbjct: 304 ALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPAR-----ATVTINVT-DVNDNPPN 357
Query: 570 IP-DFMGAPYE--FWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF---AVE 623
I ++ +P ++ + T + I V+D + DV+ ++ E VPF AV
Sbjct: 358 IDLRYIISPINGTVYLSEKDPVNTKIALITVSD--KDTDVNGKVICFIEREVPFHLKAVY 415
Query: 624 ERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLLKGAHS 682
+ ++ L + F+ VA +L+ V + D ND + +
Sbjct: 416 DNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF----NQ 471
Query: 683 PII-FHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
P+I V EN+ G + I T+ S G V L N D + G +
Sbjct: 472 PVIELSVSENNRRGLYLTTISATDEDS--GKNADIVYQLGPNASFFDLD---RKTGVLTA 526
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
+ DRE+++ + TV A N G V + + DENDN P F H ++ F+ EN
Sbjct: 527 SRVFDREEQERFIFTVTARDN-GTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL 585
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIM 860
+ + +I TDAD G N ++ + + F +D +GV+K S DRE++
Sbjct: 586 PKYSTV---GVITVTDADAGENKAVTLSILND-NDNFVLDPYSGVIK-SNVSFDREQQSS 640
Query: 861 YKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTI 918
Y + A D G SS A++ I + D NDN P N+ ++ L+ G +
Sbjct: 641 YTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKL---VPLSAIPGSVV 697
Query: 919 IEVKPKNKFALDVD 932
EV FA+DVD
Sbjct: 698 AEV-----FAVDVD 706
Score = 83.0 bits (196), Expect = 7e-15
Identities = 116/467 (24%), Positives = 190/467 (40%), Gaps = 63/467 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN I + +A D D+G NG YE + S D +E E+
Sbjct: 151 IPENTLINSRFPIPSATDPDTGFNGVQHYELLNG----QSVFGLDIVETPE----GEKWP 202
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNIS--VRVFVKDVNDHFPVFKKTWYNFNVE 1055
+IV ++L E + + + I DGG + + ++V V DVND+ PVFK+ ++
Sbjct: 203 QLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIP 262
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYF----IQPSDTDLPFEISPLTGVLSVNGELDRE 1111
E + ++ ATDAD G NA + Y + P+ L F ++ TG+++V LDRE
Sbjct: 263 ENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FALNNTTGLITVQRSLDRE 321
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF---YAFDELLEWKHPEADEL 1168
+ +TV+A D DVNDN P Y + + +
Sbjct: 322 ETAIHKVTVLASDG---SSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDP 378
Query: 1169 SNHNFESVMMIPVYKATIEENAPIGTTVAKVF------ANDTDFIGNGNGLILYSLPQRK 1222
N + +I V + N + + + D ++ + L+ Y +
Sbjct: 379 VN---TKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEF 435
Query: 1223 N----QQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVS 1278
+ + G PSL+ TA++ V + D E + P+F EL + EN + L +
Sbjct: 436 SFKIVASDSGKPSLNQTALVRVKLED-----ENDNPPIFNQPVIELSVSENNRRGLYLTT 490
Query: 1279 LNLTEHYENFKMR-YYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAER 1337
++ T+ Y L N + F +D + G L R DRE ++ + V A R
Sbjct: 491 ISATDEDSGKNADIVYQLGPNAS----FFDLDRKTGVLTASRVFDREEQERFIFTVTA-R 545
Query: 1338 QKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGN 1384
+ L + V+V + D NDNSPKFT+ +
Sbjct: 546 DNGTPPL----------------QSQAAVIVTVLDENDNSPKFTHNH 576
Score = 80.6 bits (190), Expect = 4e-14
Identities = 58/188 (30%), Positives = 85/188 (45%), Gaps = 9/188 (4%)
Query: 198 QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEK 257
Q VI S ++ L+ I A D+D G A + Y+L G + F LD G L +
Sbjct: 471 QPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASR 528
Query: 258 ELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVE 317
D + + F+ V A P +QA V + +LD NDN P+F + + + E
Sbjct: 529 VFDREEQER-----FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSE 583
Query: 318 NLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSL 377
NLP +V + TD D GEN T + + F +DP SG +++ DRE SS
Sbjct: 584 NLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSG--VIKSNVSFDREQQSSY 641
Query: 378 RMKVYAKE 385
V A +
Sbjct: 642 TFDVKATD 649
Score = 79.4 bits (187), Expect = 9e-14
Identities = 60/180 (33%), Positives = 91/180 (50%), Gaps = 14/180 (7%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNL---QAN 270
FP P A D D G YEL++G + +F LD V EK L + NL Q +
Sbjct: 161 FPIP-SATDPDTGFNGVQHYELLNG--QSVFGLDIVETPEG-EKWPQLIVQQNLDREQKD 216
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
T+V++++ P K++ A +++ + D+NDN P F+ + I EN P G SV+Q+ A
Sbjct: 217 TYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHA 276
Query: 331 TDKDQGENGEFTY-----QLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TD D G N E Y K F+++ +G +TV Q LDRE + ++ V A +
Sbjct: 277 TDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITV--QRSLDREETAIHKVTVLASD 334
Score = 64.5 bits (150), Expect = 3e-09
Identities = 68/270 (25%), Positives = 116/270 (42%), Gaps = 24/270 (8%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V L D NDN P+F + E S+ N + G + + A D D G+N ++Y L ++
Sbjct: 455 VRVKLEDENDNPPIF-NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS 513
Query: 505 LTITSPFKINPNTG--TVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F ++ TG T S + R V A D P + + ++ V ++
Sbjct: 514 F-----FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLD---- 564
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN--DAFEQNDVSYDLLHGYEEGVPF 620
+ P F ++F+V N+ ++VG I V DA E V+ +L+ + F
Sbjct: 565 ---ENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---F 618
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTNATVHVVDVNDERGVLLKG 679
++ SGVI R + Y F+ A S T++V+DVND V++
Sbjct: 619 VLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVI-S 677
Query: 680 AHSPIIFHVKENSA--GAAIGQIFHTNMSS 707
S F + SA G+ + ++F ++ +
Sbjct: 678 PPSNTSFKLVPLSAIPGSVVAEVFAVDVDT 707
Score = 63.7 bits (148), Expect = 5e-09
Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 2/114 (1%)
Query: 272 FVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMAT 331
F ++ AS P A V ++L D NDN P F +S+ EN G + + AT
Sbjct: 435 FSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISAT 494
Query: 332 DKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D+D G+N + YQL F +D ++G LT V DRE V A++
Sbjct: 495 DEDSGKNADIVYQLGPNASFFDLDRKTGVLTA--SRVFDREEQERFIFTVTARD 546
Score = 62.9 bits (146), Expect = 9e-09
Identities = 99/390 (25%), Positives = 155/390 (39%), Gaps = 62/390 (15%)
Query: 940 IPENIPIGTTIIKLNALDLDS--GLNGQIRYEFNSEVYIPPS-KLSADALEVKRYFVINE 996
+PEN+PIG LN +++ G + + Y S+ P K+S+ E+ F +
Sbjct: 34 LPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEI---FTTSN 90
Query: 997 R--HGHVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
R + S E+E F L + L I +++ VKD ND+ P+F N
Sbjct: 91 RIDREKLCAGASYAEENECFFELEVVILPNDFFR-LIKIKIIVKDTNDNAPMFPSPVINI 149
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGE 1107
++ E ATD D G N Y + + +I L V
Sbjct: 150 SIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQN 209
Query: 1108 LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE 1167
LDRE +D Y++ + D G DVNDN P F + +
Sbjct: 210 LDREQKDTYVMKIKVEDGG-TPQKSSTAILQVTVSDVNDNRPVF------------KEGQ 256
Query: 1168 LSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL 1227
+ H IP ENAP+GT+V ++ A D D IG+ N I Y +
Sbjct: 257 VEVH-------IP-------ENAPVGTSVIQLHATDAD-IGS-NAEIRYIFGAQVAPATK 300
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN 1287
L +L++T L +TV D E + I + L + + V++N+T+
Sbjct: 301 RLFALNNTTGL-ITVQRSLDREETA-----IHKVTVLASDGSSTPARATVTINVTD---- 350
Query: 1288 FKMRYYILNENDTDIRRTFVIDPRNGTLYL 1317
+N+N +I ++I P NGT+YL
Sbjct: 351 -------VNDNPPNIDLRYIISPINGTVYL 373
Score = 59.7 bits (138), Expect = 8e-08
Identities = 76/320 (23%), Positives = 135/320 (42%), Gaps = 38/320 (11%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE----------LTPTGEKA 116
+V +G ++ V V +ED NDN PIF ++V E ++ T E +
Sbjct: 439 IVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDS 498
Query: 117 F--IFLIAPIGPSLTIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFAL 174
++ +GP+ + + R + R FDR++ + V+ D+G L
Sbjct: 499 GKNADIVYQLGPNASF-FDLDRKTGVLTASRVFDREE-----QERFIFTVTARDNGTPPL 552
Query: 175 ESSHKPVLLLRKVLDYDAG--DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLR 232
+S ++ + D FQ + + + + I D D G +
Sbjct: 553 QSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV----ITVTDADAGENKAVT 608
Query: 233 YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV 292
+++ ND F LD +G ++ + D E Q +++ V+A+ P +++ A+V
Sbjct: 609 LSILNDNDN--FVLDPYSG--VIKSNVSFDRE---QQSSYTFDVKATDGGQPPRSSTAKV 661
Query: 293 EIELLDLNDNLPEFEVDFYNISI----VENLPNGFSVLQVMATDKDQGENGEFTYQL--D 346
I ++D+NDN P N S + +P G V +V A D D G N E Y +
Sbjct: 662 TINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELKYTIVSG 720
Query: 347 DPKGAFSIDPRSGWLTVRNQ 366
+ KG F IDP +G +T+ +
Sbjct: 721 NNKGLFRIDPVTGNITLEEK 740
Score = 59.3 bits (137), Expect = 1e-07
Identities = 47/151 (31%), Positives = 74/151 (49%), Gaps = 10/151 (6%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
S V + ++D NDN+PV + PSN + +A G+V+ +V AVD D G N + Y
Sbjct: 657 STAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYT 716
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVT 556
+ +N + F+I+P TG +++ E P G H L V SD + ++L +V
Sbjct: 717 IVSGNNKGL---FRIDPVTGNITLEEKPAPTDVGLHRLVVNISD--LGYPKSLHTLVLVF 771
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVG 587
+ V T GN I D + E + N+G
Sbjct: 772 LYV-NDTAGNASYIYDLIRRTMETPLDRNIG 801
Score = 33.1 bits (72), Expect = 7.9
Identities = 19/46 (41%), Positives = 28/46 (60%), Gaps = 4/46 (8%)
Query: 1441 ATDSDIGINADIRYQILNEQAPR----FAIDPVSGTVRVVAALARD 1482
ATD+DIG NA+IRY + AP FA++ +G + V +L R+
Sbjct: 276 ATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDRE 321
>AL136999-1|CAM13771.1| 1237|Homo sapiens protocadherin 9 protein.
Length = 1237
Score = 142 bits (345), Expect = 7e-33
Identities = 167/629 (26%), Positives = 276/629 (43%), Gaps = 82/629 (13%)
Query: 738 IFTQKPLDREKRDVYRMTV-IAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFI 796
+ Q+ LDRE++D Y M + + + S I QVT+ D NDN PVF+ E I
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV--SDVNDNRPVFKEGQVEVHI 261
Query: 797 MENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG-----KEMFDVDENTGVVKFIGD 851
EN+ +GT + + ATDAD G+NA Y +FG K +F ++ TG++ +
Sbjct: 262 PENAPVGTSVIQ---LHATDADIGSNAEIRY-IFGAQVAPATKRLFALNNTTGLIT-VQR 316
Query: 852 SLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
SLDRE+ ++K++++A D G S+ A + I N + N N +R + + +N
Sbjct: 317 SLDREETAIHKVTVLASD--GSSTPARATVTI-----NVTDVNDNPPNIDLR-YIISPIN 368
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
GT + E P+ T I + D D+ +NG++
Sbjct: 369 GTV------------------------YLSEKDPVNTKIALITVSDKDTDVNGKVICFIE 404
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGG--NLNDNI 1029
EV P L A + +Y + EF I A D G +LN
Sbjct: 405 REV---PFHLKA--VYDNQYLLETSS------LLDYEGTKEFSFKIVASDSGKPSLNQTA 453
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
VRV ++D ND+ P+F + +V E L + ATD D G+NA++ Y + P+ +
Sbjct: 454 LVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS 513
Query: 1090 DLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
F++ TGVL+ + DRE ++++I TV ARDNG D NDNSP
Sbjct: 514 F--FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVL-DENDNSP 570
Query: 1150 KFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGN 1209
KF ++ ++ L ++ +V +I V A EN + T++ + ND +
Sbjct: 571 KFTHN----HFQFFVSENLPKYS--TVGVITVTDADAGENKAV--TLSILNDNDNFVLDP 622
Query: 1210 GNGLILYSLPQRKNQQNL----------GLPSLSSTAILMVTVADVPDEVEMSDKPVFIS 1259
+G+I ++ + QQ+ G P SSTA + + V DV D + P +
Sbjct: 623 YSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNT 682
Query: 1260 RYYELEIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVR 1319
+ + + + V V + N +++Y I++ N+ + F IDP G + L
Sbjct: 683 SFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGL---FRIDPVTGNITLEE 739
Query: 1320 SPDREVKDTYEVIVRAERQKYSRELPHMI 1348
P + ++V Y + L ++
Sbjct: 740 KPAPTDVGLHRLVVNISDLGYPKSLHTLV 768
Score = 125 bits (301), Expect = 1e-27
Identities = 176/674 (26%), Positives = 278/674 (41%), Gaps = 60/674 (8%)
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGF-SVLQVMATDKD 334
V+ S + T R++ E L + E F+ + +V LPN F ++++ KD
Sbjct: 76 VKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVI-LPNDFFRLIKIKIIVKD 134
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLR-MKVYAKETNPSVVGT 393
+N P SI P + + R + + ++ Y SV G
Sbjct: 135 TNDNAPM---FPSPVINISI-PENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGL 190
Query: 394 -FADSQRIAKWRRQPLETNAPLE-KTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLD 451
++ KW + ++ N E K TYV KV + Q S ++VT+ D
Sbjct: 191 DIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVE------DGGTPQKSSTAILQVTVSD 244
Query: 452 ANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPF 511
NDN PVF + E + NA VGT + ++ A D D+G N + Y F
Sbjct: 245 VNDNRPVFKEGQV-EVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLF 303
Query: 512 KINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPD 569
+N TG ++V S E H + V ASD + P+ A VTI VT N P+
Sbjct: 304 ALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPAR-----ATVTINVT-DVNDNPPN 357
Query: 570 IP-DFMGAPYE--FWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF---AVE 623
I ++ +P ++ + T + I V+D + DV+ ++ E VPF AV
Sbjct: 358 IDLRYIISPINGTVYLSEKDPVNTKIALITVSD--KDTDVNGKVICFIEREVPFHLKAVY 415
Query: 624 ERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLLKGAHS 682
+ ++ L + F+ VA +L+ V + D ND + +
Sbjct: 416 DNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF----NQ 471
Query: 683 PII-FHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
P+I V EN+ G + I T+ S G V L N D + G +
Sbjct: 472 PVIELSVSENNRRGLYLTTISATDEDS--GKNADIVYQLGPNASFFDLD---RKTGVLTA 526
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
+ DRE+++ + TV A N G V + + DENDN P F H ++ F+ EN
Sbjct: 527 SRVFDREEQERFIFTVTARDN-GTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL 585
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIM 860
+ + +I TDAD G N ++ + + F +D +GV+K S DRE++
Sbjct: 586 PKYSTV---GVITVTDADAGENKAVTLSILND-NDNFVLDPYSGVIK-SNVSFDREQQSS 640
Query: 861 YKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTI 918
Y + A D G SS A++ I + D NDN P N+ ++ L+ G +
Sbjct: 641 YTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKL---VPLSAIPGSVV 697
Query: 919 IEVKPKNKFALDVD 932
EV FA+DVD
Sbjct: 698 AEV-----FAVDVD 706
Score = 83.0 bits (196), Expect = 7e-15
Identities = 116/467 (24%), Positives = 190/467 (40%), Gaps = 63/467 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN I + +A D D+G NG YE + S D +E E+
Sbjct: 151 IPENTLINSRFPIPSATDPDTGFNGVQHYELLNG----QSVFGLDIVETPE----GEKWP 202
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNIS--VRVFVKDVNDHFPVFKKTWYNFNVE 1055
+IV ++L E + + + I DGG + + ++V V DVND+ PVFK+ ++
Sbjct: 203 QLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIP 262
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYF----IQPSDTDLPFEISPLTGVLSVNGELDRE 1111
E + ++ ATDAD G NA + Y + P+ L F ++ TG+++V LDRE
Sbjct: 263 ENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FALNNTTGLITVQRSLDRE 321
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF---YAFDELLEWKHPEADEL 1168
+ +TV+A D DVNDN P Y + + +
Sbjct: 322 ETAIHKVTVLASDG---SSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDP 378
Query: 1169 SNHNFESVMMIPVYKATIEENAPIGTTVAKVF------ANDTDFIGNGNGLILYSLPQRK 1222
N + +I V + N + + + D ++ + L+ Y +
Sbjct: 379 VN---TKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEF 435
Query: 1223 N----QQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVS 1278
+ + G PSL+ TA++ V + D E + P+F EL + EN + L +
Sbjct: 436 SFKIVASDSGKPSLNQTALVRVKLED-----ENDNPPIFNQPVIELSVSENNRRGLYLTT 490
Query: 1279 LNLTEHYENFKMR-YYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAER 1337
++ T+ Y L N + F +D + G L R DRE ++ + V A R
Sbjct: 491 ISATDEDSGKNADIVYQLGPNAS----FFDLDRKTGVLTASRVFDREEQERFIFTVTA-R 545
Query: 1338 QKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGN 1384
+ L + V+V + D NDNSPKFT+ +
Sbjct: 546 DNGTPPL----------------QSQAAVIVTVLDENDNSPKFTHNH 576
Score = 80.6 bits (190), Expect = 4e-14
Identities = 58/188 (30%), Positives = 85/188 (45%), Gaps = 9/188 (4%)
Query: 198 QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEK 257
Q VI S ++ L+ I A D+D G A + Y+L G + F LD G L +
Sbjct: 471 QPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASR 528
Query: 258 ELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVE 317
D + + F+ V A P +QA V + +LD NDN P+F + + + E
Sbjct: 529 VFDREEQER-----FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSE 583
Query: 318 NLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSL 377
NLP +V + TD D GEN T + + F +DP SG +++ DRE SS
Sbjct: 584 NLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSG--VIKSNVSFDREQQSSY 641
Query: 378 RMKVYAKE 385
V A +
Sbjct: 642 TFDVKATD 649
Score = 79.4 bits (187), Expect = 9e-14
Identities = 60/180 (33%), Positives = 91/180 (50%), Gaps = 14/180 (7%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNL---QAN 270
FP P A D D G YEL++G + +F LD V EK L + NL Q +
Sbjct: 161 FPIP-SATDPDTGFNGVQHYELLNG--QSVFGLDIVETPEG-EKWPQLIVQQNLDREQKD 216
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
T+V++++ P K++ A +++ + D+NDN P F+ + I EN P G SV+Q+ A
Sbjct: 217 TYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHA 276
Query: 331 TDKDQGENGEFTY-----QLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TD D G N E Y K F+++ +G +TV Q LDRE + ++ V A +
Sbjct: 277 TDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITV--QRSLDREETAIHKVTVLASD 334
Score = 64.5 bits (150), Expect = 3e-09
Identities = 68/270 (25%), Positives = 116/270 (42%), Gaps = 24/270 (8%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V L D NDN P+F + E S+ N + G + + A D D G+N ++Y L ++
Sbjct: 455 VRVKLEDENDNPPIF-NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS 513
Query: 505 LTITSPFKINPNTG--TVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F ++ TG T S + R V A D P + + ++ V ++
Sbjct: 514 F-----FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLD---- 564
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN--DAFEQNDVSYDLLHGYEEGVPF 620
+ P F ++F+V N+ ++VG I V DA E V+ +L+ + F
Sbjct: 565 ---ENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---F 618
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTNATVHVVDVNDERGVLLKG 679
++ SGVI R + Y F+ A S T++V+DVND V++
Sbjct: 619 VLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVI-S 677
Query: 680 AHSPIIFHVKENSA--GAAIGQIFHTNMSS 707
S F + SA G+ + ++F ++ +
Sbjct: 678 PPSNTSFKLVPLSAIPGSVVAEVFAVDVDT 707
Score = 63.7 bits (148), Expect = 5e-09
Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 2/114 (1%)
Query: 272 FVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMAT 331
F ++ AS P A V ++L D NDN P F +S+ EN G + + AT
Sbjct: 435 FSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISAT 494
Query: 332 DKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D+D G+N + YQL F +D ++G LT V DRE V A++
Sbjct: 495 DEDSGKNADIVYQLGPNASFFDLDRKTGVLTA--SRVFDREEQERFIFTVTARD 546
Score = 62.9 bits (146), Expect = 9e-09
Identities = 99/390 (25%), Positives = 155/390 (39%), Gaps = 62/390 (15%)
Query: 940 IPENIPIGTTIIKLNALDLDS--GLNGQIRYEFNSEVYIPPS-KLSADALEVKRYFVINE 996
+PEN+PIG LN +++ G + + Y S+ P K+S+ E+ F +
Sbjct: 34 LPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEI---FTTSN 90
Query: 997 R--HGHVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
R + S E+E F L + L I +++ VKD ND+ P+F N
Sbjct: 91 RIDREKLCAGASYAEENECFFELEVVILPNDFFR-LIKIKIIVKDTNDNAPMFPSPVINI 149
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGE 1107
++ E ATD D G N Y + + +I L V
Sbjct: 150 SIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQN 209
Query: 1108 LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE 1167
LDRE +D Y++ + D G DVNDN P F + +
Sbjct: 210 LDREQKDTYVMKIKVEDGG-TPQKSSTAILQVTVSDVNDNRPVF------------KEGQ 256
Query: 1168 LSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL 1227
+ H IP ENAP+GT+V ++ A D D IG+ N I Y +
Sbjct: 257 VEVH-------IP-------ENAPVGTSVIQLHATDAD-IGS-NAEIRYIFGAQVAPATK 300
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN 1287
L +L++T L +TV D E + I + L + + V++N+T+
Sbjct: 301 RLFALNNTTGL-ITVQRSLDREETA-----IHKVTVLASDGSSTPARATVTINVTD---- 350
Query: 1288 FKMRYYILNENDTDIRRTFVIDPRNGTLYL 1317
+N+N +I ++I P NGT+YL
Sbjct: 351 -------VNDNPPNIDLRYIISPINGTVYL 373
Score = 59.7 bits (138), Expect = 8e-08
Identities = 76/320 (23%), Positives = 135/320 (42%), Gaps = 38/320 (11%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE----------LTPTGEKA 116
+V +G ++ V V +ED NDN PIF ++V E ++ T E +
Sbjct: 439 IVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDS 498
Query: 117 F--IFLIAPIGPSLTIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFAL 174
++ +GP+ + + R + R FDR++ + V+ D+G L
Sbjct: 499 GKNADIVYQLGPNASF-FDLDRKTGVLTASRVFDREE-----QERFIFTVTARDNGTPPL 552
Query: 175 ESSHKPVLLLRKVLDYDAG--DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLR 232
+S ++ + D FQ + + + + I D D G +
Sbjct: 553 QSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV----ITVTDADAGENKAVT 608
Query: 233 YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV 292
+++ ND F LD +G ++ + D E Q +++ V+A+ P +++ A+V
Sbjct: 609 LSILNDNDN--FVLDPYSG--VIKSNVSFDRE---QQSSYTFDVKATDGGQPPRSSTAKV 661
Query: 293 EIELLDLNDNLPEFEVDFYNISI----VENLPNGFSVLQVMATDKDQGENGEFTYQL--D 346
I ++D+NDN P N S + +P G V +V A D D G N E Y +
Sbjct: 662 TINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELKYTIVSG 720
Query: 347 DPKGAFSIDPRSGWLTVRNQ 366
+ KG F IDP +G +T+ +
Sbjct: 721 NNKGLFRIDPVTGNITLEEK 740
Score = 59.3 bits (137), Expect = 1e-07
Identities = 47/151 (31%), Positives = 74/151 (49%), Gaps = 10/151 (6%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
S V + ++D NDN+PV + PSN + +A G+V+ +V AVD D G N + Y
Sbjct: 657 STAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYT 716
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVT 556
+ +N + F+I+P TG +++ E P G H L V SD + ++L +V
Sbjct: 717 IVSGNNKGL---FRIDPVTGNITLEEKPAPTDVGLHRLVVNISD--LGYPKSLHTLVLVF 771
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVG 587
+ V T GN I D + E + N+G
Sbjct: 772 LYV-NDTAGNASYIYDLIRRTMETPLDRNIG 801
Score = 33.1 bits (72), Expect = 7.9
Identities = 19/46 (41%), Positives = 28/46 (60%), Gaps = 4/46 (8%)
Query: 1441 ATDSDIGINADIRYQILNEQAPR----FAIDPVSGTVRVVAALARD 1482
ATD+DIG NA+IRY + AP FA++ +G + V +L R+
Sbjct: 276 ATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDRE 321
>AF169692-1|AAF89689.2| 1203|Homo sapiens protocadherin-9 protein.
Length = 1203
Score = 142 bits (345), Expect = 7e-33
Identities = 167/629 (26%), Positives = 276/629 (43%), Gaps = 82/629 (13%)
Query: 738 IFTQKPLDREKRDVYRMTV-IAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFI 796
+ Q+ LDRE++D Y M + + + S I QVT+ D NDN PVF+ E I
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTV--SDVNDNRPVFKEGQVEVHI 261
Query: 797 MENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG-----KEMFDVDENTGVVKFIGD 851
EN+ +GT + + ATDAD G+NA Y +FG K +F ++ TG++ +
Sbjct: 262 PENAPVGTSVIQ---LHATDADIGSNAEIRY-IFGAQVAPATKRLFALNNTTGLIT-VQR 316
Query: 852 SLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
SLDRE+ ++K++++A D G S+ A + I N + N N +R + + +N
Sbjct: 317 SLDREETAIHKVTVLASD--GSSTPARATVTI-----NVTDVNDNPPNIDLR-YIISPIN 368
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
GT + E P+ T I + D D+ +NG++
Sbjct: 369 GTV------------------------YLSEKDPVNTKIALITVSDKDTDVNGKVICFIE 404
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGG--NLNDNI 1029
EV P L A + +Y + EF I A D G +LN
Sbjct: 405 REV---PFHLKA--VYDNQYLLETSS------LLDYEGTKEFSFKIVASDSGKPSLNQTA 453
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
VRV ++D ND+ P+F + +V E L + ATD D G+NA++ Y + P+ +
Sbjct: 454 LVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS 513
Query: 1090 DLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
F++ TGVL+ + DRE ++++I TV ARDNG D NDNSP
Sbjct: 514 F--FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVL-DENDNSP 570
Query: 1150 KFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGN 1209
KF ++ ++ L ++ +V +I V A EN + T++ + ND +
Sbjct: 571 KFTHN----HFQFFVSENLPKYS--TVGVITVTDADAGENKAV--TLSILNDNDNFVLDP 622
Query: 1210 GNGLILYSLPQRKNQQNL----------GLPSLSSTAILMVTVADVPDEVEMSDKPVFIS 1259
+G+I ++ + QQ+ G P SSTA + + V DV D + P +
Sbjct: 623 YSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNT 682
Query: 1260 RYYELEIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVR 1319
+ + + + V V + N +++Y I++ N+ + F IDP G + L
Sbjct: 683 SFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGL---FRIDPVTGNITLEE 739
Query: 1320 SPDREVKDTYEVIVRAERQKYSRELPHMI 1348
P + ++V Y + L ++
Sbjct: 740 KPAPTDVGLHRLVVNISDLGYPKSLHTLV 768
Score = 125 bits (301), Expect = 1e-27
Identities = 176/674 (26%), Positives = 278/674 (41%), Gaps = 60/674 (8%)
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGF-SVLQVMATDKD 334
V+ S + T R++ E L + E F+ + +V LPN F ++++ KD
Sbjct: 76 VKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVI-LPNDFFRLIKIKIIVKD 134
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLR-MKVYAKETNPSVVGT 393
+N P SI P + + R + + ++ Y SV G
Sbjct: 135 TNDNAPM---FPSPVINISI-PENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGL 190
Query: 394 -FADSQRIAKWRRQPLETNAPLE-KTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLD 451
++ KW + ++ N E K TYV KV + Q S ++VT+ D
Sbjct: 191 DIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVE------DGGTPQKSSTAILQVTVSD 244
Query: 452 ANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPF 511
NDN PVF + E + NA VGT + ++ A D D+G N + Y F
Sbjct: 245 VNDNRPVFKEGQV-EVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLF 303
Query: 512 KINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPD 569
+N TG ++V S E H + V ASD + P+ A VTI VT N P+
Sbjct: 304 ALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPAR-----ATVTINVT-DVNDNPPN 357
Query: 570 IP-DFMGAPYE--FWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF---AVE 623
I ++ +P ++ + T + I V+D + DV+ ++ E VPF AV
Sbjct: 358 IDLRYIISPINGTVYLSEKDPVNTKIALITVSD--KDTDVNGKVICFIEREVPFHLKAVY 415
Query: 624 ERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLLKGAHS 682
+ ++ L + F+ VA +L+ V + D ND + +
Sbjct: 416 DNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF----NQ 471
Query: 683 PII-FHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
P+I V EN+ G + I T+ S G V L N D + G +
Sbjct: 472 PVIELSVSENNRRGLYLTTISATDEDS--GKNADIVYQLGPNASFFDLD---RKTGVLTA 526
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
+ DRE+++ + TV A N G V + + DENDN P F H ++ F+ EN
Sbjct: 527 SRVFDREEQERFIFTVTARDN-GTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL 585
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIM 860
+ + +I TDAD G N ++ + + F +D +GV+K S DRE++
Sbjct: 586 PKYSTV---GVITVTDADAGENKAVTLSILND-NDNFVLDPYSGVIK-SNVSFDREQQSS 640
Query: 861 YKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTI 918
Y + A D G SS A++ I + D NDN P N+ ++ L+ G +
Sbjct: 641 YTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKL---VPLSAIPGSVV 697
Query: 919 IEVKPKNKFALDVD 932
EV FA+DVD
Sbjct: 698 AEV-----FAVDVD 706
Score = 83.0 bits (196), Expect = 7e-15
Identities = 116/467 (24%), Positives = 190/467 (40%), Gaps = 63/467 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN I + +A D D+G NG YE + S D +E E+
Sbjct: 151 IPENTLINSRFPIPSATDPDTGFNGVQHYELLNG----QSVFGLDIVETPE----GEKWP 202
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNIS--VRVFVKDVNDHFPVFKKTWYNFNVE 1055
+IV ++L E + + + I DGG + + ++V V DVND+ PVFK+ ++
Sbjct: 203 QLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIP 262
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYF----IQPSDTDLPFEISPLTGVLSVNGELDRE 1111
E + ++ ATDAD G NA + Y + P+ L F ++ TG+++V LDRE
Sbjct: 263 ENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FALNNTTGLITVQRSLDRE 321
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF---YAFDELLEWKHPEADEL 1168
+ +TV+A D DVNDN P Y + + +
Sbjct: 322 ETAIHKVTVLASDG---SSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDP 378
Query: 1169 SNHNFESVMMIPVYKATIEENAPIGTTVAKVF------ANDTDFIGNGNGLILYSLPQRK 1222
N + +I V + N + + + D ++ + L+ Y +
Sbjct: 379 VN---TKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEF 435
Query: 1223 N----QQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVS 1278
+ + G PSL+ TA++ V + D E + P+F EL + EN + L +
Sbjct: 436 SFKIVASDSGKPSLNQTALVRVKLED-----ENDNPPIFNQPVIELSVSENNRRGLYLTT 490
Query: 1279 LNLTEHYENFKMR-YYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAER 1337
++ T+ Y L N + F +D + G L R DRE ++ + V A R
Sbjct: 491 ISATDEDSGKNADIVYQLGPNAS----FFDLDRKTGVLTASRVFDREEQERFIFTVTA-R 545
Query: 1338 QKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGN 1384
+ L + V+V + D NDNSPKFT+ +
Sbjct: 546 DNGTPPL----------------QSQAAVIVTVLDENDNSPKFTHNH 576
Score = 80.6 bits (190), Expect = 4e-14
Identities = 58/188 (30%), Positives = 85/188 (45%), Gaps = 9/188 (4%)
Query: 198 QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEK 257
Q VI S ++ L+ I A D+D G A + Y+L G + F LD G L +
Sbjct: 471 QPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASR 528
Query: 258 ELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVE 317
D + + F+ V A P +QA V + +LD NDN P+F + + + E
Sbjct: 529 VFDREEQER-----FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSE 583
Query: 318 NLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSL 377
NLP +V + TD D GEN T + + F +DP SG +++ DRE SS
Sbjct: 584 NLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSG--VIKSNVSFDREQQSSY 641
Query: 378 RMKVYAKE 385
V A +
Sbjct: 642 TFDVKATD 649
Score = 79.4 bits (187), Expect = 9e-14
Identities = 60/180 (33%), Positives = 91/180 (50%), Gaps = 14/180 (7%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNL---QAN 270
FP P A D D G YEL++G + +F LD V EK L + NL Q +
Sbjct: 161 FPIP-SATDPDTGFNGVQHYELLNG--QSVFGLDIVETPEG-EKWPQLIVQQNLDREQKD 216
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
T+V++++ P K++ A +++ + D+NDN P F+ + I EN P G SV+Q+ A
Sbjct: 217 TYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHA 276
Query: 331 TDKDQGENGEFTY-----QLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TD D G N E Y K F+++ +G +TV Q LDRE + ++ V A +
Sbjct: 277 TDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITV--QRSLDREETAIHKVTVLASD 334
Score = 64.5 bits (150), Expect = 3e-09
Identities = 68/270 (25%), Positives = 116/270 (42%), Gaps = 24/270 (8%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V L D NDN P+F + E S+ N + G + + A D D G+N ++Y L ++
Sbjct: 455 VRVKLEDENDNPPIF-NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNAS 513
Query: 505 LTITSPFKINPNTG--TVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F ++ TG T S + R V A D P + + ++ V ++
Sbjct: 514 F-----FDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLD---- 564
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN--DAFEQNDVSYDLLHGYEEGVPF 620
+ P F ++F+V N+ ++VG I V DA E V+ +L+ + F
Sbjct: 565 ---ENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---F 618
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTNATVHVVDVNDERGVLLKG 679
++ SGVI R + Y F+ A S T++V+DVND V++
Sbjct: 619 VLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVI-S 677
Query: 680 AHSPIIFHVKENSA--GAAIGQIFHTNMSS 707
S F + SA G+ + ++F ++ +
Sbjct: 678 PPSNTSFKLVPLSAIPGSVVAEVFAVDVDT 707
Score = 63.7 bits (148), Expect = 5e-09
Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 2/114 (1%)
Query: 272 FVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMAT 331
F ++ AS P A V ++L D NDN P F +S+ EN G + + AT
Sbjct: 435 FSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISAT 494
Query: 332 DKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D+D G+N + YQL F +D ++G LT V DRE V A++
Sbjct: 495 DEDSGKNADIVYQLGPNASFFDLDRKTGVLTA--SRVFDREEQERFIFTVTARD 546
Score = 62.9 bits (146), Expect = 9e-09
Identities = 99/390 (25%), Positives = 155/390 (39%), Gaps = 62/390 (15%)
Query: 940 IPENIPIGTTIIKLNALDLDS--GLNGQIRYEFNSEVYIPPS-KLSADALEVKRYFVINE 996
+PEN+PIG LN +++ G + + Y S+ P K+S+ E+ F +
Sbjct: 34 LPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEI---FTTSN 90
Query: 997 R--HGHVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
R + S E+E F L + L I +++ VKD ND+ P+F N
Sbjct: 91 RIDREKLCAGASYAEENECFFELEVVILPNDFFR-LIKIKIIVKDTNDNAPMFPSPVINI 149
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGE 1107
++ E ATD D G N Y + + +I L V
Sbjct: 150 SIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQN 209
Query: 1108 LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE 1167
LDRE +D Y++ + D G DVNDN P F + +
Sbjct: 210 LDREQKDTYVMKIKVEDGG-TPQKSSTAILQVTVSDVNDNRPVF------------KEGQ 256
Query: 1168 LSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL 1227
+ H IP ENAP+GT+V ++ A D D IG+ N I Y +
Sbjct: 257 VEVH-------IP-------ENAPVGTSVIQLHATDAD-IGS-NAEIRYIFGAQVAPATK 300
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN 1287
L +L++T L +TV D E + I + L + + V++N+T+
Sbjct: 301 RLFALNNTTGL-ITVQRSLDREETA-----IHKVTVLASDGSSTPARATVTINVTD---- 350
Query: 1288 FKMRYYILNENDTDIRRTFVIDPRNGTLYL 1317
+N+N +I ++I P NGT+YL
Sbjct: 351 -------VNDNPPNIDLRYIISPINGTVYL 373
Score = 59.7 bits (138), Expect = 8e-08
Identities = 76/320 (23%), Positives = 135/320 (42%), Gaps = 38/320 (11%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE----------LTPTGEKA 116
+V +G ++ V V +ED NDN PIF ++V E ++ T E +
Sbjct: 439 IVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDS 498
Query: 117 F--IFLIAPIGPSLTIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFAL 174
++ +GP+ + + R + R FDR++ + V+ D+G L
Sbjct: 499 GKNADIVYQLGPNASF-FDLDRKTGVLTASRVFDREE-----QERFIFTVTARDNGTPPL 552
Query: 175 ESSHKPVLLLRKVLDYDAG--DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLR 232
+S ++ + D FQ + + + + I D D G +
Sbjct: 553 QSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGV----ITVTDADAGENKAVT 608
Query: 233 YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV 292
+++ ND F LD +G ++ + D E Q +++ V+A+ P +++ A+V
Sbjct: 609 LSILNDNDN--FVLDPYSG--VIKSNVSFDRE---QQSSYTFDVKATDGGQPPRSSTAKV 661
Query: 293 EIELLDLNDNLPEFEVDFYNISI----VENLPNGFSVLQVMATDKDQGENGEFTYQL--D 346
I ++D+NDN P N S + +P G V +V A D D G N E Y +
Sbjct: 662 TINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELKYTIVSG 720
Query: 347 DPKGAFSIDPRSGWLTVRNQ 366
+ KG F IDP +G +T+ +
Sbjct: 721 NNKGLFRIDPVTGNITLEEK 740
Score = 59.3 bits (137), Expect = 1e-07
Identities = 47/151 (31%), Positives = 74/151 (49%), Gaps = 10/151 (6%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
S V + ++D NDN+PV + PSN + +A G+V+ +V AVD D G N + Y
Sbjct: 657 STAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYT 716
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVT 556
+ +N + F+I+P TG +++ E P G H L V SD + ++L +V
Sbjct: 717 IVSGNNKGL---FRIDPVTGNITLEEKPAPTDVGLHRLVVNISD--LGYPKSLHTLVLVF 771
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVG 587
+ V T GN I D + E + N+G
Sbjct: 772 LYV-NDTAGNASYIYDLIRRTMETPLDRNIG 801
Score = 33.1 bits (72), Expect = 7.9
Identities = 19/46 (41%), Positives = 28/46 (60%), Gaps = 4/46 (8%)
Query: 1441 ATDSDIGINADIRYQILNEQAPR----FAIDPVSGTVRVVAALARD 1482
ATD+DIG NA+IRY + AP FA++ +G + V +L R+
Sbjct: 276 ATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDRE 321
>AY029237-1|AAK31804.1| 1955|Homo sapiens protocadherin 15 protein.
Length = 1955
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 493 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 549
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 550 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 606
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 607 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 661
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 719
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 720 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 773
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 774 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 833 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 887
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 928
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 801 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 854
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 911
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 912 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 967
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 968 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1078
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1079 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1194 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 754
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 755 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 809 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 860
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 921 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 978 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1033
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1034 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1087
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1088 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 525 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 570
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 631 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 688 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 736
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 737 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 796 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 851 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 894
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 426
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 483
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 484 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 538
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 539 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQL 619
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1122
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1123 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1182
Query: 345 LDDP 348
L P
Sbjct: 1183 LIIP 1186
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 698
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 757
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 758 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 793
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 786
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 847 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 884
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 649
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 650 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 702
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 703 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 756
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 757 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 815 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 865
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 866 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 926 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 983 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 702 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 759
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 760 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 817
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 818 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 992 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 810 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 859
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 860 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 973
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 974 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 479
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 480 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITI 567
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 533 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 586
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 645
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 646 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 700
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 979 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1037
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1093
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1094 PLDYETRTSYVLRVQA 1109
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 466 LQPVDREEQQTYTFSITAFDGVQESEPVIV 495
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1183
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
>AY029205-1|AAK31581.1| 1955|Homo sapiens protocadherin 15 protein.
Length = 1955
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 493 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 549
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 550 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 606
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 607 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 661
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 719
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 720 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 773
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 774 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 833 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 887
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 928
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 801 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 854
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 911
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 912 VTVIV----KDMNDYPPVFSKQIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 967
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 968 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1078
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1079 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1194 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 754
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 755 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 809 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 860
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 921 DYPPVFSKQIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 978 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1033
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1034 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1087
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1088 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 525 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 570
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 631 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 688 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 736
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 737 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 796 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 851 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 894
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Score = 73.3 bits (172), Expect = 6e-12
Identities = 115/502 (22%), Positives = 207/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 249 TTLTVDVLDGDDSGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 426
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + P+DRE++ Y ++ A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLLPVDREEQQTYTFSITA- 483
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 484 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 538
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 539 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQL 619
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1122
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1123 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1182
Query: 345 LDDP 348
L P
Sbjct: 1183 LIIP 1186
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 698
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 757
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 758 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 793
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 786
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 847 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 884
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 649
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 650 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 702
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 703 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 756
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 757 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 815 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 865
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 866 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 926 FSKQIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 983 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Score = 62.9 bits (146), Expect = 9e-09
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 702 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 759
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 760 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 817
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 818 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKQIY 931
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 992 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Score = 62.1 bits (144), Expect = 1e-08
Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L L +D E + T+
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLLPVDRE---EQQTYTF 479
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 480 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITI 567
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 810 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 859
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 860 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 915 IVKDMNDYPPVFSKQIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 973
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 974 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 533 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 586
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 645
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 646 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 700
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 979 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1037
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1093
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1094 PLDYETRTSYVLRVQA 1109
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.9 bits (89), Expect = 0.069
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDSGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 466 LLPVDREEQQTYTFSITAFDGVQESEPVIV 495
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1183
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
>AL365496-10|CAM19874.1| 1957|Homo sapiens protocadherin 15 protein.
Length = 1957
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 493 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 549
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 550 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 606
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 607 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 661
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 719
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 720 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 773
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 774 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 833 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 887
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 928
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 801 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 854
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 911
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 912 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 967
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 968 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1078
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1079 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1194 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 754
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 755 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 809 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 860
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 921 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 978 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1033
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1034 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1087
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1088 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 525 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 570
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 631 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 688 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 736
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 737 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 796 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 851 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 894
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 426
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 483
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 484 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 538
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 539 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQL 619
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1122
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1123 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1182
Query: 345 LDDP 348
L P
Sbjct: 1183 LIIP 1186
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 698
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 757
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 758 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 793
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 786
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 847 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 884
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 649
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 650 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 702
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 703 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 756
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 757 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 815 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 865
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 866 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 926 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 983 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 702 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 759
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 760 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 817
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 818 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 992 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 810 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 859
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 860 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 973
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 974 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 479
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 480 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITI 567
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 533 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 586
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 645
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 646 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 700
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 979 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1037
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1093
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1094 PLDYETRTSYVLRVQA 1109
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 466 LQPVDREEQQTYTFSITAFDGVQESEPVIV 495
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1183
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
>AL365496-9|CAH73916.1| 1955|Homo sapiens protocadherin 15 protein.
Length = 1955
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 493 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 549
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 550 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 606
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 607 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 661
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 719
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 720 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 773
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 774 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 833 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 887
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 928
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 801 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 854
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 911
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 912 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 967
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 968 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1078
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1079 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1194 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 754
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 755 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 809 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 860
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 921 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 978 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1033
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1034 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1087
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1088 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 525 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 570
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 631 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 688 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 736
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 737 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 796 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 851 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 894
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 426
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 483
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 484 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 538
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 539 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQL 619
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1122
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1123 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1182
Query: 345 LDDP 348
L P
Sbjct: 1183 LIIP 1186
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 698
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 757
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 758 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 793
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 786
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 847 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 884
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 649
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 650 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 702
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 703 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 756
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 757 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 815 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 865
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 866 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 926 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 983 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 702 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 759
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 760 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 817
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 818 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 992 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 810 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 859
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 860 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 973
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 974 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 479
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 480 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITI 567
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 533 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 586
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 645
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 646 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 700
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 979 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1037
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1093
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1094 PLDYETRTSYVLRVQA 1109
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 466 LQPVDREEQQTYTFSITAFDGVQESEPVIV 495
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1183
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
>AL365496-8|CAM19873.1| 1952|Homo sapiens protocadherin 15 protein.
Length = 1952
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 493 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 549
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 550 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 606
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 607 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 661
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 719
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 720 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 773
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 774 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 833 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 887
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 928
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 801 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 854
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 911
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 912 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 967
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 968 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1078
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1079 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1194 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 754
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 755 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 809 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 860
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 921 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 978 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1033
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1034 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1087
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1088 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 525 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 570
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 631 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 688 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 736
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 737 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 796 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 851 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 894
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 426
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 483
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 484 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 538
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 539 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQL 619
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1122
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1123 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1182
Query: 345 LDDP 348
L P
Sbjct: 1183 LIIP 1186
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 698
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 757
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 758 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 793
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 786
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 847 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 884
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 649
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 650 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 702
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 703 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 756
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 757 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 815 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 865
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 866 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 926 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 983 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 702 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 759
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 760 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 817
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 818 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 992 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 810 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 859
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 860 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 973
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 974 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 479
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 480 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITI 567
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 533 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 586
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 645
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 646 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 700
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 979 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1037
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1093
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1094 PLDYETRTSYVLRVQA 1109
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 466 LQPVDREEQQTYTFSITAFDGVQESEPVIV 495
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1183
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
>AL365496-7|CAM19872.1| 1932|Homo sapiens protocadherin 15 protein.
Length = 1932
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 471 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 527
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 528 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 584
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 585 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 639
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 640 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 697
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 698 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 751
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 752 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 810
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 811 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 865
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 866 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 906
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 779 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 832
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 833 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 889
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 890 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 945
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 946 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1003
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1004 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1056
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1057 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1114
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1115 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1171
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1172 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 677 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 732
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 733 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 786
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 787 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 838
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 839 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 898
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 899 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 955
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 956 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1011
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1012 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1065
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1066 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1124
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 503 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 548
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 549 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 608
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 609 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 665
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 666 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 714
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 715 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 773
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 774 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 828
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 829 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 872
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 873 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 905
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 170 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 226
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 227 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 286
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 287 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 346
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 347 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 404
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 405 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 461
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 462 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 516
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 517 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 575
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 576 ICTVYIEVLPPNNQSPPRFPQL 597
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1041 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1100
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1101 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1160
Query: 345 LDDP 348
L P
Sbjct: 1161 LIIP 1164
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 623 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 676
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 677 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 735
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 736 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 771
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 713 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 764
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 765 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 824
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 825 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 862
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 571 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 627
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 628 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 680
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 681 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 734
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 735 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 792
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 793 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 843
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 844 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 903
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 904 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 960
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 961 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1017
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 680 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 737
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 738 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 795
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 796 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 850
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 851 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 909
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 910 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 969
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 970 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 998
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 788 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 837
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 838 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 892
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 893 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 951
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 952 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 990
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 401 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 457
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 458 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 515
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 516 EGSNGEITYEILVGAQGDFIINKTTGLITI 545
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 511 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 564
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 565 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 623
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 624 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 678
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 452 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 511
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 512 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 566
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 957 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1015
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1016 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1071
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1072 PLDYETRTSYVLRVQA 1087
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 77 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 134
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 135 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 214
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 65 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 122
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 123 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 176
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 108 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 145
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 215 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 269
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 270 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 328
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 329 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 383
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 384 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 443
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 444 LQPVDREEQQTYTFSITAFDGVQESEPVIV 473
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1103 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1161
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1162 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1205
>AL365496-4|CAM19869.1| 1539|Homo sapiens protocadherin 15 protein.
Length = 1539
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 493 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 549
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 550 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 606
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 607 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 661
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 719
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 720 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 773
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 774 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 833 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 887
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 928
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 801 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 854
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 911
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 912 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 967
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 968 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1078
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1079 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1194 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 754
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 755 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 809 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 860
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 921 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 978 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1033
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1034 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1087
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1088 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 525 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 570
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 631 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 688 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 736
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 737 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 796 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 851 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 894
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 426
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 483
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 484 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 538
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 539 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQL 619
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1122
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1123 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1182
Query: 345 LDDP 348
L P
Sbjct: 1183 LIIP 1186
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 698
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 757
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 758 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 793
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 786
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 847 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 884
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 649
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 650 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 702
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 703 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 756
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 757 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 815 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 865
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 866 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 926 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 983 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 702 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 759
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 760 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 817
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 818 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 992 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 810 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 859
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 860 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 973
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 974 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 479
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 480 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITI 567
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 533 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 586
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 645
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 646 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 700
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 979 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1037
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1093
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1094 PLDYETRTSYVLRVQA 1109
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 466 LQPVDREEQQTYTFSITAFDGVQESEPVIV 495
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1183
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
>AL365496-3|CAM19868.1| 1785|Homo sapiens protocadherin 15 protein.
Length = 1785
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 500 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 556
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 557 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 613
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 614 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 668
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 669 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 726
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 727 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 780
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 781 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 839
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 840 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 894
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 895 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 935
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 808 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 861
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 862 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 918
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 919 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 974
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 975 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1032
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1033 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1085
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1086 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1143
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1144 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1200
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1201 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1254
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 706 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 761
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 762 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 815
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 816 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 867
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 868 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 927
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 928 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 984
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 985 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1040
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1041 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1094
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1095 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1153
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 532 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 577
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 578 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 637
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 638 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 694
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 695 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 743
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 744 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 802
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 803 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 857
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 858 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 901
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 902 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 934
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1070 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1129
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1130 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1189
Query: 345 LDDP 348
L P
Sbjct: 1190 LIIP 1193
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 652 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 705
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 706 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 764
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 765 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 800
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 742 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 793
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 794 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 853
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 854 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 891
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 600 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 656
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 657 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 709
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 710 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 763
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 764 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 821
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 822 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 872
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 873 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 932
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 933 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 989
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 990 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1046
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 709 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 766
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 767 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 824
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 825 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 879
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 880 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 938
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 939 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 998
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 999 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1027
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 817 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 866
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 867 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 921
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 922 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 980
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 981 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1019
Score = 58.4 bits (135), Expect = 2e-07
Identities = 28/73 (38%), Positives = 45/73 (61%), Gaps = 1/73 (1%)
Query: 292 VEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ-LDDPKG 350
V I+++D NDN P F Y++ + ++ G SV+Q+ A D D+G NGE TY+ L +G
Sbjct: 502 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG 561
Query: 351 AFSIDPRSGWLTV 363
F I+ +G +T+
Sbjct: 562 DFIINKTTGLITI 574
Score = 52.8 bits (121), Expect = 9e-06
Identities = 41/160 (25%), Positives = 74/160 (46%), Gaps = 12/160 (7%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
+P+DRE++ Y ++ A F+ GV + V I + D NDN P F +Y+ ++ + +
Sbjct: 474 QPVDREEQQTYTFSITA-FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMR 530
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMY 861
G + + A DADEG+N Y + + F +++ TG++ I ++ Y
Sbjct: 531 PGDSVIQ---LTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTY 586
Query: 862 KLSLVARDTGGLSSEAELIIMIGDE-----NDNKPEFNQI 896
L++ A D + I + E N + P F Q+
Sbjct: 587 ALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQL 626
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 540 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 593
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 594 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 652
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 653 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 707
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 481 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 540
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 541 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 595
Score = 49.6 bits (113), Expect = 8e-05
Identities = 49/175 (28%), Positives = 88/175 (50%), Gaps = 26/175 (14%)
Query: 742 KPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMEN 799
+P++R+ + + + AE + G + + AG++ I I DEN+ P F +Y+G+I+E+
Sbjct: 351 EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLH---IEILDENNQSPYFTMPSYQGYILES 407
Query: 800 SKIGTEIKMDNI-------IKATDAD------EG--TNALFMYTLFGEGKEMFDVDENTG 844
+ +G I D++ I A D D G T ++ + +F V + TG
Sbjct: 408 APVGATIS-DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQ-TG 465
Query: 845 VVKFIG--DSLDREKKIMYKLSLVARDTGGLSSEAELI-IMIGDENDNKPEFNQI 896
+ +++ +DRE++ Y S+ A D G SE ++ I + D NDN P F +I
Sbjct: 466 ITRYLTLLQPVDREEQQTYTFSITAFD-GVQESEPVIVNIQVMDANDNTPTFPEI 519
Score = 46.8 bits (106), Expect = 6e-04
Identities = 39/130 (30%), Positives = 62/130 (47%), Gaps = 16/130 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRG 562
+T++V G
Sbjct: 249 TTLTVDVLDG 258
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 986 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1044
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1045 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1100
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1101 PLDYETRTSYVLRVQA 1116
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 37.5 bits (83), Expect = 0.37
Identities = 51/207 (24%), Positives = 88/207 (42%), Gaps = 28/207 (13%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD 334
E+ P G ++ L+++A DKD
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKD 432
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1132 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1190
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1191 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1234
>AL365496-1|CAM19866.1| 1684|Homo sapiens protocadherin 15 protein.
Length = 1684
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 500 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 556
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 557 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 613
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 614 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 668
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 669 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 726
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 727 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 780
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 781 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 839
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 840 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 894
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 895 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 935
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 808 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 861
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 862 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 918
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 919 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 974
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 975 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1032
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1033 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1085
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1086 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1143
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1144 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1200
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1201 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1254
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 706 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 761
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 762 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 815
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 816 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 867
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 868 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 927
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 928 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 984
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 985 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1040
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1041 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1094
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1095 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1153
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 532 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 577
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 578 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 637
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 638 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 694
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 695 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 743
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 744 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 802
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 803 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 857
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 858 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 901
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 902 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 934
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1070 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1129
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1130 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1189
Query: 345 LDDP 348
L P
Sbjct: 1190 LIIP 1193
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 652 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 705
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 706 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 764
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 765 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 800
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 742 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 793
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 794 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 853
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 854 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 891
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 600 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 656
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 657 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 709
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 710 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 763
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 764 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 821
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 822 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 872
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 873 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 932
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 933 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 989
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 990 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1046
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 709 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 766
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 767 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 824
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 825 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 879
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 880 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 938
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 939 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 998
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 999 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1027
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 817 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 866
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 867 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 921
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 922 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 980
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 981 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1019
Score = 58.4 bits (135), Expect = 2e-07
Identities = 28/73 (38%), Positives = 45/73 (61%), Gaps = 1/73 (1%)
Query: 292 VEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ-LDDPKG 350
V I+++D NDN P F Y++ + ++ G SV+Q+ A D D+G NGE TY+ L +G
Sbjct: 502 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG 561
Query: 351 AFSIDPRSGWLTV 363
F I+ +G +T+
Sbjct: 562 DFIINKTTGLITI 574
Score = 52.8 bits (121), Expect = 9e-06
Identities = 41/160 (25%), Positives = 74/160 (46%), Gaps = 12/160 (7%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
+P+DRE++ Y ++ A F+ GV + V I + D NDN P F +Y+ ++ + +
Sbjct: 474 QPVDREEQQTYTFSITA-FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMR 530
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMY 861
G + + A DADEG+N Y + + F +++ TG++ I ++ Y
Sbjct: 531 PGDSVIQ---LTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTY 586
Query: 862 KLSLVARDTGGLSSEAELIIMIGDE-----NDNKPEFNQI 896
L++ A D + I + E N + P F Q+
Sbjct: 587 ALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQL 626
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 540 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 593
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 594 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 652
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 653 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 707
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 481 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 540
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 541 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 595
Score = 49.6 bits (113), Expect = 8e-05
Identities = 49/175 (28%), Positives = 88/175 (50%), Gaps = 26/175 (14%)
Query: 742 KPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMEN 799
+P++R+ + + + AE + G + + AG++ I I DEN+ P F +Y+G+I+E+
Sbjct: 351 EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLH---IEILDENNQSPYFTMPSYQGYILES 407
Query: 800 SKIGTEIKMDNI-------IKATDAD------EG--TNALFMYTLFGEGKEMFDVDENTG 844
+ +G I D++ I A D D G T ++ + +F V + TG
Sbjct: 408 APVGATIS-DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQ-TG 465
Query: 845 VVKFIG--DSLDREKKIMYKLSLVARDTGGLSSEAELI-IMIGDENDNKPEFNQI 896
+ +++ +DRE++ Y S+ A D G SE ++ I + D NDN P F +I
Sbjct: 466 ITRYLTLLQPVDREEQQTYTFSITAFD-GVQESEPVIVNIQVMDANDNTPTFPEI 519
Score = 46.8 bits (106), Expect = 6e-04
Identities = 39/130 (30%), Positives = 62/130 (47%), Gaps = 16/130 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRG 562
+T++V G
Sbjct: 249 TTLTVDVLDG 258
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 986 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1044
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1045 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1100
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1101 PLDYETRTSYVLRVQA 1116
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 37.5 bits (83), Expect = 0.37
Identities = 51/207 (24%), Positives = 88/207 (42%), Gaps = 28/207 (13%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD 334
E+ P G ++ L+++A DKD
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKD 432
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1132 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1190
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1191 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1234
>AL360214-13|CAM21544.1| 1932|Homo sapiens protocadherin 15 protein.
Length = 1932
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 471 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 527
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 528 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 584
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 585 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 639
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 640 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 697
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 698 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 751
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 752 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 810
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 811 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 865
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 866 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 906
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 779 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 832
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 833 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 889
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 890 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 945
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 946 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1003
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1004 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1056
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1057 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1114
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1115 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1171
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1172 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 677 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 732
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 733 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 786
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 787 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 838
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 839 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 898
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 899 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 955
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 956 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1011
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1012 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1065
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1066 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1124
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 503 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 548
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 549 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 608
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 609 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 665
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 666 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 714
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 715 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 773
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 774 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 828
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 829 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 872
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 873 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 905
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 170 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 226
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 227 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 286
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 287 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 346
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 347 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 404
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 405 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 461
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 462 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 516
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 517 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 575
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 576 ICTVYIEVLPPNNQSPPRFPQL 597
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1041 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1100
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1101 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1160
Query: 345 LDDP 348
L P
Sbjct: 1161 LIIP 1164
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 623 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 676
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 677 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 735
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 736 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 771
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 713 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 764
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 765 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 824
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 825 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 862
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 571 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 627
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 628 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 680
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 681 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 734
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 735 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 792
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 793 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 843
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 844 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 903
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 904 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 960
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 961 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1017
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 680 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 737
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 738 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 795
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 796 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 850
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 851 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 909
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 910 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 969
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 970 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 998
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 788 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 837
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 838 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 892
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 893 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 951
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 952 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 990
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 401 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 457
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 458 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 515
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 516 EGSNGEITYEILVGAQGDFIINKTTGLITI 545
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 511 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 564
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 565 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 623
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 624 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 678
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 452 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 511
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 512 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 566
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 957 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1015
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1016 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1071
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1072 PLDYETRTSYVLRVQA 1087
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 77 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 134
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 135 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 214
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 65 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 122
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 123 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 176
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 108 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 145
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 215 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 269
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 270 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 328
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 329 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 383
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 384 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 443
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 444 LQPVDREEQQTYTFSITAFDGVQESEPVIV 473
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1103 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1161
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1162 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1205
>AL360214-12|CAM21543.1| 1952|Homo sapiens protocadherin 15 protein.
Length = 1952
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 493 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 549
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 550 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 606
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 607 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 661
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 719
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 720 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 773
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 774 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 833 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 887
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 928
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 801 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 854
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 911
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 912 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 967
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 968 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1078
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1079 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1194 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 754
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 755 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 809 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 860
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 921 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 978 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1033
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1034 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1087
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1088 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 525 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 570
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 631 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 688 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 736
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 737 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 796 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 851 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 894
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 426
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 483
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 484 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 538
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 539 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQL 619
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1122
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1123 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1182
Query: 345 LDDP 348
L P
Sbjct: 1183 LIIP 1186
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 698
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 757
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 758 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 793
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 786
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 847 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 884
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 649
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 650 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 702
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 703 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 756
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 757 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 815 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 865
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 866 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 926 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 983 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 702 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 759
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 760 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 817
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 818 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 992 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 810 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 859
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 860 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 973
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 974 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 479
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 480 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITI 567
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 533 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 586
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 645
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 646 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 700
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 979 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1037
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1093
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1094 PLDYETRTSYVLRVQA 1109
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 466 LQPVDREEQQTYTFSITAFDGVQESEPVIV 495
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1183
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
>AL360214-11|CAM21542.1| 1957|Homo sapiens protocadherin 15 protein.
Length = 1957
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 493 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 549
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 550 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 606
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 607 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 661
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 719
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 720 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 773
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 774 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 833 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 887
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 928
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 801 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 854
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 911
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 912 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 967
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 968 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1078
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1079 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1194 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 754
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 755 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 809 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 860
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 921 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 978 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1033
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1034 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1087
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1088 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 525 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 570
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 631 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 688 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 736
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 737 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 796 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 851 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 894
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 426
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 483
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 484 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 538
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 539 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQL 619
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1122
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1123 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1182
Query: 345 LDDP 348
L P
Sbjct: 1183 LIIP 1186
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 698
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 757
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 758 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 793
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 786
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 847 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 884
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 649
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 650 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 702
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 703 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 756
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 757 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 815 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 865
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 866 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 926 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 983 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 702 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 759
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 760 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 817
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 818 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 992 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 810 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 859
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 860 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 973
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 974 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 479
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 480 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITI 567
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 533 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 586
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 645
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 646 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 700
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 979 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1037
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1093
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1094 PLDYETRTSYVLRVQA 1109
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 466 LQPVDREEQQTYTFSITAFDGVQESEPVIV 495
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1183
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
>AL360214-10|CAI15201.1| 1955|Homo sapiens protocadherin 15 protein.
Length = 1955
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 493 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 549
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 550 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 606
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 607 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 661
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 719
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 720 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 773
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 774 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 833 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 887
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 928
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 801 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 854
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 911
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 912 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 967
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 968 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1078
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1079 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1194 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 754
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 755 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 809 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 860
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 921 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 978 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1033
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1034 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1087
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1088 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 525 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 570
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 631 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 688 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 736
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 737 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 796 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 851 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 894
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 426
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 483
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 484 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 538
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 539 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQL 619
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1122
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1123 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1182
Query: 345 LDDP 348
L P
Sbjct: 1183 LIIP 1186
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 698
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 757
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 758 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 793
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 786
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 847 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 884
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 649
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 650 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 702
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 703 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 756
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 757 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 815 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 865
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 866 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 926 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 983 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 702 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 759
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 760 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 817
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 818 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 992 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 810 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 859
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 860 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 973
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 974 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 479
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 480 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITI 567
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 533 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 586
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 645
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 646 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 700
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 979 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1037
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1093
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1094 PLDYETRTSYVLRVQA 1109
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 466 LQPVDREEQQTYTFSITAFDGVQESEPVIV 495
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1183
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
>AL360214-6|CAM21538.1| 1785|Homo sapiens protocadherin 15 protein.
Length = 1785
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 500 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 556
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 557 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 613
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 614 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 668
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 669 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 726
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 727 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 780
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 781 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 839
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 840 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 894
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 895 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 935
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 808 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 861
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 862 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 918
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 919 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 974
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 975 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1032
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1033 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1085
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1086 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1143
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1144 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1200
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1201 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1254
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 706 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 761
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 762 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 815
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 816 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 867
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 868 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 927
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 928 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 984
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 985 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1040
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1041 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1094
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1095 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1153
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 532 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 577
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 578 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 637
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 638 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 694
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 695 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 743
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 744 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 802
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 803 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 857
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 858 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 901
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 902 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 934
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1070 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1129
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1130 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1189
Query: 345 LDDP 348
L P
Sbjct: 1190 LIIP 1193
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 652 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 705
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 706 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 764
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 765 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 800
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 742 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 793
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 794 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 853
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 854 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 891
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 600 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 656
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 657 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 709
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 710 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 763
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 764 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 821
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 822 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 872
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 873 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 932
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 933 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 989
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 990 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1046
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 709 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 766
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 767 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 824
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 825 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 879
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 880 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 938
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 939 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 998
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 999 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1027
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 817 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 866
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 867 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 921
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 922 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 980
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 981 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1019
Score = 58.4 bits (135), Expect = 2e-07
Identities = 28/73 (38%), Positives = 45/73 (61%), Gaps = 1/73 (1%)
Query: 292 VEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ-LDDPKG 350
V I+++D NDN P F Y++ + ++ G SV+Q+ A D D+G NGE TY+ L +G
Sbjct: 502 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG 561
Query: 351 AFSIDPRSGWLTV 363
F I+ +G +T+
Sbjct: 562 DFIINKTTGLITI 574
Score = 52.8 bits (121), Expect = 9e-06
Identities = 41/160 (25%), Positives = 74/160 (46%), Gaps = 12/160 (7%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
+P+DRE++ Y ++ A F+ GV + V I + D NDN P F +Y+ ++ + +
Sbjct: 474 QPVDREEQQTYTFSITA-FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMR 530
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMY 861
G + + A DADEG+N Y + + F +++ TG++ I ++ Y
Sbjct: 531 PGDSVIQ---LTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTY 586
Query: 862 KLSLVARDTGGLSSEAELIIMIGDE-----NDNKPEFNQI 896
L++ A D + I + E N + P F Q+
Sbjct: 587 ALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQL 626
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 540 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 593
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 594 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 652
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 653 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 707
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 481 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 540
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 541 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 595
Score = 49.6 bits (113), Expect = 8e-05
Identities = 49/175 (28%), Positives = 88/175 (50%), Gaps = 26/175 (14%)
Query: 742 KPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMEN 799
+P++R+ + + + AE + G + + AG++ I I DEN+ P F +Y+G+I+E+
Sbjct: 351 EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLH---IEILDENNQSPYFTMPSYQGYILES 407
Query: 800 SKIGTEIKMDNI-------IKATDAD------EG--TNALFMYTLFGEGKEMFDVDENTG 844
+ +G I D++ I A D D G T ++ + +F V + TG
Sbjct: 408 APVGATIS-DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQ-TG 465
Query: 845 VVKFIG--DSLDREKKIMYKLSLVARDTGGLSSEAELI-IMIGDENDNKPEFNQI 896
+ +++ +DRE++ Y S+ A D G SE ++ I + D NDN P F +I
Sbjct: 466 ITRYLTLLQPVDREEQQTYTFSITAFD-GVQESEPVIVNIQVMDANDNTPTFPEI 519
Score = 46.8 bits (106), Expect = 6e-04
Identities = 39/130 (30%), Positives = 62/130 (47%), Gaps = 16/130 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRG 562
+T++V G
Sbjct: 249 TTLTVDVLDG 258
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 986 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1044
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1045 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1100
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1101 PLDYETRTSYVLRVQA 1116
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 37.5 bits (83), Expect = 0.37
Identities = 51/207 (24%), Positives = 88/207 (42%), Gaps = 28/207 (13%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD 334
E+ P G ++ L+++A DKD
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKD 432
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1132 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1190
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1191 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1234
>AL360214-5|CAM21537.1| 1539|Homo sapiens protocadherin 15 protein.
Length = 1539
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 493 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 549
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 550 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 606
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 607 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 661
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 719
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 720 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 773
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 774 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 833 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 887
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 928
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 801 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 854
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 911
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 912 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 967
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 968 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1078
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1079 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1194 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 754
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 755 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 809 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 860
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 921 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 978 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1033
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1034 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1087
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1088 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 525 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 570
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 631 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 688 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 736
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 737 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 796 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 851 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 894
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 426
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 483
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 484 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 538
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 539 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQL 619
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1122
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1123 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1182
Query: 345 LDDP 348
L P
Sbjct: 1183 LIIP 1186
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 698
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 757
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 758 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 793
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 786
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 847 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 884
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 649
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 650 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 702
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 703 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 756
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 757 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 815 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 865
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 866 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 926 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 983 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 702 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 759
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 760 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 817
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 818 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 992 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 810 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 859
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 860 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 973
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 974 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 479
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 480 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITI 567
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 533 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 586
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 645
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 646 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 700
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 979 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1037
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1093
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1094 PLDYETRTSYVLRVQA 1109
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 466 LQPVDREEQQTYTFSITAFDGVQESEPVIV 495
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1183
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
>AL360214-4|CAM21536.1| 1684|Homo sapiens protocadherin 15 protein.
Length = 1684
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 500 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 556
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 557 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 613
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 614 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 668
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 669 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 726
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 727 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 780
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 781 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 839
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 840 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 894
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 895 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 935
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 808 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 861
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 862 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 918
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 919 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 974
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 975 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1032
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1033 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1085
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1086 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1143
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1144 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1200
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1201 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1254
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 706 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 761
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 762 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 815
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 816 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 867
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 868 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 927
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 928 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 984
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 985 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1040
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1041 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1094
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1095 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1153
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 532 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 577
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 578 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 637
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 638 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 694
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 695 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 743
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 744 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 802
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 803 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 857
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 858 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 901
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 902 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 934
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1070 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1129
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1130 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1189
Query: 345 LDDP 348
L P
Sbjct: 1190 LIIP 1193
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 652 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 705
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 706 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 764
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 765 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 800
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 742 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 793
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 794 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 853
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 854 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 891
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 600 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 656
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 657 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 709
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 710 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 763
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 764 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 821
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 822 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 872
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 873 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 932
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 933 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 989
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 990 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1046
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 709 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 766
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 767 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 824
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 825 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 879
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 880 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 938
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 939 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 998
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 999 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1027
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 817 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 866
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 867 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 921
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 922 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 980
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 981 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1019
Score = 58.4 bits (135), Expect = 2e-07
Identities = 28/73 (38%), Positives = 45/73 (61%), Gaps = 1/73 (1%)
Query: 292 VEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ-LDDPKG 350
V I+++D NDN P F Y++ + ++ G SV+Q+ A D D+G NGE TY+ L +G
Sbjct: 502 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG 561
Query: 351 AFSIDPRSGWLTV 363
F I+ +G +T+
Sbjct: 562 DFIINKTTGLITI 574
Score = 52.8 bits (121), Expect = 9e-06
Identities = 41/160 (25%), Positives = 74/160 (46%), Gaps = 12/160 (7%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
+P+DRE++ Y ++ A F+ GV + V I + D NDN P F +Y+ ++ + +
Sbjct: 474 QPVDREEQQTYTFSITA-FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMR 530
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMY 861
G + + A DADEG+N Y + + F +++ TG++ I ++ Y
Sbjct: 531 PGDSVIQ---LTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTY 586
Query: 862 KLSLVARDTGGLSSEAELIIMIGDE-----NDNKPEFNQI 896
L++ A D + I + E N + P F Q+
Sbjct: 587 ALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQL 626
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 540 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 593
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 594 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 652
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 653 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 707
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 481 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 540
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 541 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 595
Score = 49.6 bits (113), Expect = 8e-05
Identities = 49/175 (28%), Positives = 88/175 (50%), Gaps = 26/175 (14%)
Query: 742 KPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMEN 799
+P++R+ + + + AE + G + + AG++ I I DEN+ P F +Y+G+I+E+
Sbjct: 351 EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLH---IEILDENNQSPYFTMPSYQGYILES 407
Query: 800 SKIGTEIKMDNI-------IKATDAD------EG--TNALFMYTLFGEGKEMFDVDENTG 844
+ +G I D++ I A D D G T ++ + +F V + TG
Sbjct: 408 APVGATIS-DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQ-TG 465
Query: 845 VVKFIG--DSLDREKKIMYKLSLVARDTGGLSSEAELI-IMIGDENDNKPEFNQI 896
+ +++ +DRE++ Y S+ A D G SE ++ I + D NDN P F +I
Sbjct: 466 ITRYLTLLQPVDREEQQTYTFSITAFD-GVQESEPVIVNIQVMDANDNTPTFPEI 519
Score = 46.8 bits (106), Expect = 6e-04
Identities = 39/130 (30%), Positives = 62/130 (47%), Gaps = 16/130 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRG 562
+T++V G
Sbjct: 249 TTLTVDVLDG 258
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 986 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1044
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1045 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1100
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1101 PLDYETRTSYVLRVQA 1116
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 37.5 bits (83), Expect = 0.37
Identities = 51/207 (24%), Positives = 88/207 (42%), Gaps = 28/207 (13%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD 334
E+ P G ++ L+++A DKD
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKD 432
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1132 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1190
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1191 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1234
>AL360214-3|CAI15200.1| 961|Homo sapiens protocadherin 15 protein.
Length = 961
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 493 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 549
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 550 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 606
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 607 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 661
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 719
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 720 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 773
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 774 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 833 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 887
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 928
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 525 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 570
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 631 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 688 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 736
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 737 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 796 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 851 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 894
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 426
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 483
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 484 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 538
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 539 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQL 619
Score = 68.1 bits (159), Expect = 2e-10
Identities = 72/255 (28%), Positives = 112/255 (43%), Gaps = 28/255 (10%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 754
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 755 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 809 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 860
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
Query: 671 DERGVLLKGAHSPII 685
D V K + ++
Sbjct: 921 DYPPVFSKRIYKGMV 935
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 698
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 757
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 758 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 793
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 786
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 847 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 884
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 479
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 480 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITI 567
Score = 58.4 bits (135), Expect = 2e-07
Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 20/263 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 702 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 759
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 760 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 817
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 818 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 312 NISIVENLPNGFSVLQVMATDKD 334
+ + G + V A D D
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDAD 954
Score = 56.4 bits (130), Expect = 7e-07
Identities = 94/392 (23%), Positives = 160/392 (40%), Gaps = 40/392 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 649
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 650 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 702
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 703 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 756
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 757 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 815 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 865
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 866 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD 818
F Y+G + ++ GT I + A DAD
Sbjct: 926 FSKRIYKGMVAPDAVKGTPI---TTVYAEDAD 954
Score = 55.2 bits (127), Expect = 2e-06
Identities = 52/160 (32%), Positives = 74/160 (46%), Gaps = 30/160 (18%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 810 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 859
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 860 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD 1073
VKD+ND+ PVF K Y V + V A DAD
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 533 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 586
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 645
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 646 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 700
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 466 LQPVDREEQQTYTFSITAFDGVQESEPVIV 495
>AL356114-13|CAH71769.1| 1955|Homo sapiens protocadherin 15 protein.
Length = 1955
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 493 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 549
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 550 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 606
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 607 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 661
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 719
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 720 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 773
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 774 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 833 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 887
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 928
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 801 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 854
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 911
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 912 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 967
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 968 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1078
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1079 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1194 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 754
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 755 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 809 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 860
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 921 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 978 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1033
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1034 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1087
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1088 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 525 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 570
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 631 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 688 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 736
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 737 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 796 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 851 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 894
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 426
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 483
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 484 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 538
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 539 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQL 619
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1122
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1123 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1182
Query: 345 LDDP 348
L P
Sbjct: 1183 LIIP 1186
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 698
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 757
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 758 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 793
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 786
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 847 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 884
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 649
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 650 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 702
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 703 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 756
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 757 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 815 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 865
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 866 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 926 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 983 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 702 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 759
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 760 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 817
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 818 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 992 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 810 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 859
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 860 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 973
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 974 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 479
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 480 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITI 567
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 533 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 586
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 645
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 646 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 700
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 979 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1037
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1093
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1094 PLDYETRTSYVLRVQA 1109
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 466 LQPVDREEQQTYTFSITAFDGVQESEPVIV 495
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1183
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
>AL356114-12|CAM15125.1| 1932|Homo sapiens protocadherin 15 protein.
Length = 1932
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 471 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 527
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 528 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 584
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 585 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 639
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 640 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 697
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 698 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 751
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 752 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 810
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 811 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 865
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 866 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 906
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 779 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 832
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 833 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 889
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 890 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 945
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 946 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1003
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1004 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1056
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1057 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1114
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1115 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1171
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1172 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 677 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 732
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 733 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 786
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 787 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 838
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 839 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 898
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 899 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 955
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 956 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1011
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1012 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1065
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1066 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1124
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 503 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 548
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 549 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 608
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 609 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 665
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 666 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 714
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 715 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 773
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 774 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 828
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 829 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 872
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 873 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 905
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 170 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 226
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 227 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 286
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 287 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 346
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 347 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 404
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 405 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 461
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 462 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 516
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 517 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 575
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 576 ICTVYIEVLPPNNQSPPRFPQL 597
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1041 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1100
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1101 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1160
Query: 345 LDDP 348
L P
Sbjct: 1161 LIIP 1164
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 623 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 676
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 677 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 735
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 736 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 771
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 713 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 764
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 765 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 824
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 825 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 862
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 571 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 627
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 628 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 680
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 681 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 734
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 735 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 792
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 793 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 843
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 844 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 903
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 904 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 960
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 961 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1017
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 680 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 737
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 738 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 795
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 796 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 850
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 851 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 909
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 910 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 969
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 970 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 998
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 788 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 837
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 838 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 892
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 893 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 951
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 952 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 990
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 401 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 457
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 458 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 515
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 516 EGSNGEITYEILVGAQGDFIINKTTGLITI 545
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 511 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 564
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 565 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 623
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 624 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 678
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 452 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 511
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 512 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 566
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 957 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1015
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1016 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1071
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1072 PLDYETRTSYVLRVQA 1087
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 77 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 134
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 135 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 169
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 214
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 65 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 122
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 123 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 176
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 108 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 145
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 215 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 269
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 270 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 328
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 329 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 383
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 384 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 443
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 444 LQPVDREEQQTYTFSITAFDGVQESEPVIV 473
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1103 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1161
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1162 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1205
>AL356114-11|CAM15124.1| 1957|Homo sapiens protocadherin 15 protein.
Length = 1957
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 493 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 549
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 550 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 606
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 607 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 661
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 719
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 720 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 773
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 774 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 833 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 887
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 928
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 801 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 854
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 911
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 912 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 967
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 968 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1078
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1079 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1194 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 754
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 755 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 809 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 860
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 921 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 978 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1033
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1034 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1087
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1088 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 525 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 570
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 631 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 688 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 736
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 737 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 796 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 851 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 894
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 426
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 483
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 484 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 538
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 539 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQL 619
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1122
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1123 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1182
Query: 345 LDDP 348
L P
Sbjct: 1183 LIIP 1186
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 698
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 757
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 758 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 793
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 786
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 847 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 884
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 649
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 650 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 702
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 703 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 756
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 757 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 815 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 865
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 866 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 926 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 983 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 702 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 759
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 760 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 817
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 818 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 992 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 810 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 859
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 860 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 973
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 974 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 479
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 480 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITI 567
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 533 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 586
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 645
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 646 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 700
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 979 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1037
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1093
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1094 PLDYETRTSYVLRVQA 1109
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 466 LQPVDREEQQTYTFSITAFDGVQESEPVIV 495
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1183
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
>AL356114-10|CAM15123.1| 1952|Homo sapiens protocadherin 15 protein.
Length = 1952
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 493 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 549
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 550 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 606
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 607 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 661
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 719
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 720 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 773
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 774 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 833 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 887
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 928
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 801 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 854
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 911
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 912 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 967
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 968 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1078
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1079 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1194 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 754
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 755 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 809 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 860
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 921 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 978 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1033
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1034 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1087
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1088 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 525 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 570
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 631 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 688 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 736
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 737 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 796 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 851 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 894
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 426
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 483
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 484 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 538
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 539 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQL 619
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1122
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1123 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1182
Query: 345 LDDP 348
L P
Sbjct: 1183 LIIP 1186
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 698
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 757
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 758 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 793
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 786
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 847 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 884
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 649
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 650 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 702
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 703 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 756
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 757 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 815 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 865
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 866 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 926 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 983 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 702 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 759
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 760 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 817
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 818 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 992 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 810 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 859
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 860 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 973
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 974 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 479
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 480 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITI 567
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 533 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 586
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 645
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 646 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 700
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 979 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1037
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1093
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1094 PLDYETRTSYVLRVQA 1109
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 466 LQPVDREEQQTYTFSITAFDGVQESEPVIV 495
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1183
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
>AL356114-7|CAM15120.1| 1539|Homo sapiens protocadherin 15 protein.
Length = 1539
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 493 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 549
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 550 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 606
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 607 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 661
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 719
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 720 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 773
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 774 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 833 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 887
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 928
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 801 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 854
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 911
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 912 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 967
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 968 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1078
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1079 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1194 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 754
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 755 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 809 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 860
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 921 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 978 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1033
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1034 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1087
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1088 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 525 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 570
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 631 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 688 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 736
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 737 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 796 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 851 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 894
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 426
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 483
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 484 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 538
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 539 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQL 619
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1122
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1123 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1182
Query: 345 LDDP 348
L P
Sbjct: 1183 LIIP 1186
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 698
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 757
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 758 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 793
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 786
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 847 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 884
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 649
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 650 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 702
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 703 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 756
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 757 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 815 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 865
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 866 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 926 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 983 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 702 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 759
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 760 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 817
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 818 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 992 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 810 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 859
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 860 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 973
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 974 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 479
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 480 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITI 567
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 533 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 586
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 645
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 646 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 700
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 979 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1037
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1093
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1094 PLDYETRTSYVLRVQA 1109
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 466 LQPVDREEQQTYTFSITAFDGVQESEPVIV 495
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1183
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
>AL356114-6|CAM15119.1| 1785|Homo sapiens protocadherin 15 protein.
Length = 1785
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 500 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 556
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 557 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 613
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 614 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 668
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 669 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 726
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 727 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 780
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 781 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 839
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 840 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 894
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 895 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 935
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 808 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 861
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 862 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 918
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 919 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 974
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 975 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1032
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1033 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1085
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1086 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1143
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1144 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1200
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1201 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1254
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 706 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 761
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 762 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 815
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 816 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 867
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 868 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 927
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 928 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 984
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 985 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1040
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1041 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1094
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1095 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1153
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 532 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 577
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 578 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 637
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 638 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 694
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 695 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 743
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 744 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 802
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 803 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 857
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 858 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 901
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 902 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 934
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1070 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1129
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1130 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1189
Query: 345 LDDP 348
L P
Sbjct: 1190 LIIP 1193
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 652 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 705
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 706 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 764
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 765 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 800
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 742 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 793
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 794 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 853
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 854 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 891
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 600 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 656
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 657 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 709
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 710 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 763
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 764 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 821
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 822 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 872
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 873 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 932
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 933 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 989
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 990 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1046
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 709 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 766
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 767 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 824
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 825 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 879
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 880 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 938
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 939 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 998
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 999 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1027
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 817 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 866
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 867 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 921
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 922 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 980
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 981 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1019
Score = 58.4 bits (135), Expect = 2e-07
Identities = 28/73 (38%), Positives = 45/73 (61%), Gaps = 1/73 (1%)
Query: 292 VEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ-LDDPKG 350
V I+++D NDN P F Y++ + ++ G SV+Q+ A D D+G NGE TY+ L +G
Sbjct: 502 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG 561
Query: 351 AFSIDPRSGWLTV 363
F I+ +G +T+
Sbjct: 562 DFIINKTTGLITI 574
Score = 52.8 bits (121), Expect = 9e-06
Identities = 41/160 (25%), Positives = 74/160 (46%), Gaps = 12/160 (7%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
+P+DRE++ Y ++ A F+ GV + V I + D NDN P F +Y+ ++ + +
Sbjct: 474 QPVDREEQQTYTFSITA-FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMR 530
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMY 861
G + + A DADEG+N Y + + F +++ TG++ I ++ Y
Sbjct: 531 PGDSVIQ---LTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTY 586
Query: 862 KLSLVARDTGGLSSEAELIIMIGDE-----NDNKPEFNQI 896
L++ A D + I + E N + P F Q+
Sbjct: 587 ALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQL 626
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 540 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 593
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 594 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 652
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 653 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 707
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 481 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 540
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 541 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 595
Score = 49.6 bits (113), Expect = 8e-05
Identities = 49/175 (28%), Positives = 88/175 (50%), Gaps = 26/175 (14%)
Query: 742 KPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMEN 799
+P++R+ + + + AE + G + + AG++ I I DEN+ P F +Y+G+I+E+
Sbjct: 351 EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLH---IEILDENNQSPYFTMPSYQGYILES 407
Query: 800 SKIGTEIKMDNI-------IKATDAD------EG--TNALFMYTLFGEGKEMFDVDENTG 844
+ +G I D++ I A D D G T ++ + +F V + TG
Sbjct: 408 APVGATIS-DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQ-TG 465
Query: 845 VVKFIG--DSLDREKKIMYKLSLVARDTGGLSSEAELI-IMIGDENDNKPEFNQI 896
+ +++ +DRE++ Y S+ A D G SE ++ I + D NDN P F +I
Sbjct: 466 ITRYLTLLQPVDREEQQTYTFSITAFD-GVQESEPVIVNIQVMDANDNTPTFPEI 519
Score = 46.8 bits (106), Expect = 6e-04
Identities = 39/130 (30%), Positives = 62/130 (47%), Gaps = 16/130 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRG 562
+T++V G
Sbjct: 249 TTLTVDVLDG 258
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 986 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1044
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1045 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1100
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1101 PLDYETRTSYVLRVQA 1116
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 37.5 bits (83), Expect = 0.37
Identities = 51/207 (24%), Positives = 88/207 (42%), Gaps = 28/207 (13%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD 334
E+ P G ++ L+++A DKD
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKD 432
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1132 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1190
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1191 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1234
>AL356114-4|CAM15117.1| 1684|Homo sapiens protocadherin 15 protein.
Length = 1684
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 500 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 556
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 557 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 613
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 614 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 668
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 669 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 726
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 727 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 780
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 781 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 839
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 840 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 894
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 895 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 935
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 808 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 861
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 862 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 918
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 919 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 974
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 975 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1032
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1033 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1085
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1086 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1143
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1144 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1200
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1201 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1254
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 706 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 761
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 762 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 815
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 816 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 867
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 868 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 927
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 928 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 984
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 985 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1040
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1041 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1094
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1095 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1153
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 532 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 577
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 578 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 637
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 638 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 694
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 695 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 743
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 744 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 802
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 803 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 857
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 858 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 901
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 902 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 934
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1070 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1129
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1130 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1189
Query: 345 LDDP 348
L P
Sbjct: 1190 LIIP 1193
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 652 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 705
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 706 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 764
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 765 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 800
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 742 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 793
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 794 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 853
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 854 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 891
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 600 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 656
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 657 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 709
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 710 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 763
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 764 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 821
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 822 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 872
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 873 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 932
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 933 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 989
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 990 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1046
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 709 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 766
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 767 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 824
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 825 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 879
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 880 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 938
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 939 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 998
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 999 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1027
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 817 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 866
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 867 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 921
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 922 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 980
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 981 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1019
Score = 58.4 bits (135), Expect = 2e-07
Identities = 28/73 (38%), Positives = 45/73 (61%), Gaps = 1/73 (1%)
Query: 292 VEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ-LDDPKG 350
V I+++D NDN P F Y++ + ++ G SV+Q+ A D D+G NGE TY+ L +G
Sbjct: 502 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG 561
Query: 351 AFSIDPRSGWLTV 363
F I+ +G +T+
Sbjct: 562 DFIINKTTGLITI 574
Score = 52.8 bits (121), Expect = 9e-06
Identities = 41/160 (25%), Positives = 74/160 (46%), Gaps = 12/160 (7%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
+P+DRE++ Y ++ A F+ GV + V I + D NDN P F +Y+ ++ + +
Sbjct: 474 QPVDREEQQTYTFSITA-FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMR 530
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMY 861
G + + A DADEG+N Y + + F +++ TG++ I ++ Y
Sbjct: 531 PGDSVIQ---LTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTY 586
Query: 862 KLSLVARDTGGLSSEAELIIMIGDE-----NDNKPEFNQI 896
L++ A D + I + E N + P F Q+
Sbjct: 587 ALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQL 626
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 540 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 593
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 594 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 652
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 653 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 707
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 481 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 540
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 541 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 595
Score = 49.6 bits (113), Expect = 8e-05
Identities = 49/175 (28%), Positives = 88/175 (50%), Gaps = 26/175 (14%)
Query: 742 KPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMEN 799
+P++R+ + + + AE + G + + AG++ I I DEN+ P F +Y+G+I+E+
Sbjct: 351 EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLH---IEILDENNQSPYFTMPSYQGYILES 407
Query: 800 SKIGTEIKMDNI-------IKATDAD------EG--TNALFMYTLFGEGKEMFDVDENTG 844
+ +G I D++ I A D D G T ++ + +F V + TG
Sbjct: 408 APVGATIS-DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQ-TG 465
Query: 845 VVKFIG--DSLDREKKIMYKLSLVARDTGGLSSEAELI-IMIGDENDNKPEFNQI 896
+ +++ +DRE++ Y S+ A D G SE ++ I + D NDN P F +I
Sbjct: 466 ITRYLTLLQPVDREEQQTYTFSITAFD-GVQESEPVIVNIQVMDANDNTPTFPEI 519
Score = 46.8 bits (106), Expect = 6e-04
Identities = 39/130 (30%), Positives = 62/130 (47%), Gaps = 16/130 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRG 562
+T++V G
Sbjct: 249 TTLTVDVLDG 258
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 986 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1044
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1045 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1100
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1101 PLDYETRTSYVLRVQA 1116
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 37.5 bits (83), Expect = 0.37
Identities = 51/207 (24%), Positives = 88/207 (42%), Gaps = 28/207 (13%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD 334
E+ P G ++ L+++A DKD
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKD 432
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1132 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1190
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1191 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1234
>AL356114-3|CAH71768.1| 961|Homo sapiens protocadherin 15 protein.
Length = 961
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 493 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 549
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 550 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 606
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 607 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 661
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 719
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 720 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 773
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 774 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 833 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 887
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 928
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 525 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 570
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 631 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 688 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 736
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 737 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 796 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 851 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 894
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 426
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 483
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 484 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 538
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 539 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQL 619
Score = 68.1 bits (159), Expect = 2e-10
Identities = 72/255 (28%), Positives = 112/255 (43%), Gaps = 28/255 (10%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 754
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 755 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 809 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 860
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
Query: 671 DERGVLLKGAHSPII 685
D V K + ++
Sbjct: 921 DYPPVFSKRIYKGMV 935
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 698
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 757
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 758 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 793
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 786
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 847 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 884
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 479
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 480 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITI 567
Score = 58.4 bits (135), Expect = 2e-07
Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 20/263 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 702 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 759
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 760 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 817
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 818 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 312 NISIVENLPNGFSVLQVMATDKD 334
+ + G + V A D D
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDAD 954
Score = 56.4 bits (130), Expect = 7e-07
Identities = 94/392 (23%), Positives = 160/392 (40%), Gaps = 40/392 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 649
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 650 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 702
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 703 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 756
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 757 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 815 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 865
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 866 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD 818
F Y+G + ++ GT I + A DAD
Sbjct: 926 FSKRIYKGMVAPDAVKGTPI---TTVYAEDAD 954
Score = 55.2 bits (127), Expect = 2e-06
Identities = 52/160 (32%), Positives = 74/160 (46%), Gaps = 30/160 (18%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 810 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 859
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 860 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD 1073
VKD+ND+ PVF K Y V + V A DAD
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 533 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 586
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 645
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 646 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 700
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 466 LQPVDREEQQTYTFSITAFDGVQESEPVIV 495
>AL353784-11|CAM16792.1| 1957|Homo sapiens protocadherin 15 protein.
Length = 1957
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 493 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 549
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 550 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 606
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 607 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 661
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 719
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 720 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 773
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 774 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 833 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 887
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 928
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 801 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 854
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 911
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 912 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 967
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 968 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1078
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1079 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1194 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 754
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 755 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 809 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 860
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 921 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 978 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1033
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1034 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1087
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1088 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 525 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 570
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 631 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 688 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 736
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 737 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 796 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 851 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 894
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 426
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 483
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 484 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 538
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 539 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQL 619
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1122
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1123 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1182
Query: 345 LDDP 348
L P
Sbjct: 1183 LIIP 1186
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 698
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 757
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 758 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 793
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 786
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 847 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 884
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 649
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 650 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 702
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 703 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 756
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 757 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 815 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 865
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 866 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 926 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 983 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 702 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 759
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 760 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 817
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 818 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 992 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 810 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 859
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 860 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 973
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 974 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 479
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 480 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITI 567
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 533 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 586
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 645
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 646 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 700
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 979 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1037
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1093
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1094 PLDYETRTSYVLRVQA 1109
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 466 LQPVDREEQQTYTFSITAFDGVQESEPVIV 495
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1183
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
>AL353784-10|CAH72390.1| 1955|Homo sapiens protocadherin 15 protein.
Length = 1955
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 493 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 549
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 550 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 606
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 607 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 661
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 719
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 720 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 773
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 774 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 833 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 887
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 928
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 801 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 854
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 911
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 912 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 967
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 968 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1078
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1079 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1194 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 754
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 755 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 809 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 860
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 921 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 978 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1033
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1034 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1087
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1088 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 525 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 570
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 631 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 688 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 736
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 737 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 796 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 851 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 894
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 426
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 483
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 484 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 538
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 539 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQL 619
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1122
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1123 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1182
Query: 345 LDDP 348
L P
Sbjct: 1183 LIIP 1186
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 698
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 757
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 758 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 793
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 786
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 847 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 884
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 649
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 650 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 702
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 703 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 756
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 757 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 815 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 865
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 866 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 926 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 983 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 702 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 759
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 760 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 817
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 818 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 992 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 810 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 859
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 860 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 973
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 974 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 479
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 480 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITI 567
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 533 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 586
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 645
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 646 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 700
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 979 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1037
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1093
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1094 PLDYETRTSYVLRVQA 1109
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 466 LQPVDREEQQTYTFSITAFDGVQESEPVIV 495
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1183
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
>AL353784-9|CAM16791.1| 1952|Homo sapiens protocadherin 15 protein.
Length = 1952
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 493 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 549
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 550 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 606
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 607 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 661
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 719
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 720 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 773
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 774 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 833 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 887
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 928
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 801 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 854
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 911
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 912 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 967
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 968 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1078
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1079 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1194 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 754
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 755 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 809 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 860
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 921 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 978 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1033
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1034 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1087
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1088 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 525 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 570
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 631 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 688 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 736
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 737 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 796 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 851 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 894
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 426
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 483
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 484 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 538
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 539 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQL 619
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1122
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1123 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1182
Query: 345 LDDP 348
L P
Sbjct: 1183 LIIP 1186
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 698
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 757
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 758 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 793
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 786
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 847 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 884
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 649
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 650 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 702
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 703 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 756
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 757 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 815 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 865
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 866 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 926 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 983 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 702 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 759
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 760 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 817
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 818 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 992 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 810 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 859
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 860 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 973
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 974 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 479
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 480 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITI 567
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 533 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 586
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 645
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 646 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 700
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 979 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1037
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1093
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1094 PLDYETRTSYVLRVQA 1109
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 466 LQPVDREEQQTYTFSITAFDGVQESEPVIV 495
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1183
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
>AL353784-7|CAM16789.1| 1785|Homo sapiens protocadherin 15 protein.
Length = 1785
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 500 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 556
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 557 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 613
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 614 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 668
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 669 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 726
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 727 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 780
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 781 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 839
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 840 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 894
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 895 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 935
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 808 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 861
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 862 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 918
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 919 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 974
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 975 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1032
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1033 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1085
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1086 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1143
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1144 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1200
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1201 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1254
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 706 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 761
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 762 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 815
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 816 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 867
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 868 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 927
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 928 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 984
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 985 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1040
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1041 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1094
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1095 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1153
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 532 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 577
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 578 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 637
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 638 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 694
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 695 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 743
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 744 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 802
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 803 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 857
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 858 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 901
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 902 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 934
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1070 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1129
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1130 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1189
Query: 345 LDDP 348
L P
Sbjct: 1190 LIIP 1193
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 652 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 705
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 706 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 764
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 765 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 800
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 742 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 793
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 794 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 853
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 854 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 891
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 600 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 656
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 657 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 709
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 710 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 763
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 764 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 821
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 822 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 872
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 873 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 932
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 933 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 989
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 990 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1046
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 709 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 766
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 767 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 824
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 825 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 879
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 880 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 938
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 939 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 998
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 999 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1027
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 817 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 866
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 867 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 921
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 922 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 980
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 981 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1019
Score = 58.4 bits (135), Expect = 2e-07
Identities = 28/73 (38%), Positives = 45/73 (61%), Gaps = 1/73 (1%)
Query: 292 VEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ-LDDPKG 350
V I+++D NDN P F Y++ + ++ G SV+Q+ A D D+G NGE TY+ L +G
Sbjct: 502 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG 561
Query: 351 AFSIDPRSGWLTV 363
F I+ +G +T+
Sbjct: 562 DFIINKTTGLITI 574
Score = 52.8 bits (121), Expect = 9e-06
Identities = 41/160 (25%), Positives = 74/160 (46%), Gaps = 12/160 (7%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
+P+DRE++ Y ++ A F+ GV + V I + D NDN P F +Y+ ++ + +
Sbjct: 474 QPVDREEQQTYTFSITA-FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMR 530
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMY 861
G + + A DADEG+N Y + + F +++ TG++ I ++ Y
Sbjct: 531 PGDSVIQ---LTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTY 586
Query: 862 KLSLVARDTGGLSSEAELIIMIGDE-----NDNKPEFNQI 896
L++ A D + I + E N + P F Q+
Sbjct: 587 ALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQL 626
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 540 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 593
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 594 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 652
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 653 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 707
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 481 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 540
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 541 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 595
Score = 49.6 bits (113), Expect = 8e-05
Identities = 49/175 (28%), Positives = 88/175 (50%), Gaps = 26/175 (14%)
Query: 742 KPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMEN 799
+P++R+ + + + AE + G + + AG++ I I DEN+ P F +Y+G+I+E+
Sbjct: 351 EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLH---IEILDENNQSPYFTMPSYQGYILES 407
Query: 800 SKIGTEIKMDNI-------IKATDAD------EG--TNALFMYTLFGEGKEMFDVDENTG 844
+ +G I D++ I A D D G T ++ + +F V + TG
Sbjct: 408 APVGATIS-DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQ-TG 465
Query: 845 VVKFIG--DSLDREKKIMYKLSLVARDTGGLSSEAELI-IMIGDENDNKPEFNQI 896
+ +++ +DRE++ Y S+ A D G SE ++ I + D NDN P F +I
Sbjct: 466 ITRYLTLLQPVDREEQQTYTFSITAFD-GVQESEPVIVNIQVMDANDNTPTFPEI 519
Score = 46.8 bits (106), Expect = 6e-04
Identities = 39/130 (30%), Positives = 62/130 (47%), Gaps = 16/130 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRG 562
+T++V G
Sbjct: 249 TTLTVDVLDG 258
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 986 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1044
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1045 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1100
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1101 PLDYETRTSYVLRVQA 1116
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 37.5 bits (83), Expect = 0.37
Identities = 51/207 (24%), Positives = 88/207 (42%), Gaps = 28/207 (13%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD 334
E+ P G ++ L+++A DKD
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKD 432
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1132 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1190
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1191 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1234
>AL353784-5|CAM16787.1| 1539|Homo sapiens protocadherin 15 protein.
Length = 1539
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 493 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 549
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 550 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 606
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 607 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 661
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 719
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 720 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 773
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 774 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 833 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 887
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 928
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 801 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 854
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 911
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 912 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 967
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 968 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1078
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1079 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1194 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 754
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 755 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 809 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 860
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 921 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 978 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1033
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1034 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1087
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1088 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 525 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 570
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 631 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 688 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 736
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 737 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 796 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 851 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 894
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 426
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 483
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 484 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 538
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 539 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQL 619
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1122
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1123 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1182
Query: 345 LDDP 348
L P
Sbjct: 1183 LIIP 1186
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 698
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 757
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 758 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 793
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 786
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 847 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 884
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 649
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 650 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 702
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 703 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 756
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 757 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 815 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 865
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 866 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 926 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 983 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1039
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 702 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 759
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 760 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 817
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 818 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 992 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 810 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 859
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 860 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 973
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 974 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 479
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 480 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITI 567
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 533 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 586
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 645
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 646 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 700
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 979 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1037
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1038 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1093
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1094 PLDYETRTSYVLRVQA 1109
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 466 LQPVDREEQQTYTFSITAFDGVQESEPVIV 495
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1183
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
>AL353784-3|CAM16785.1| 1684|Homo sapiens protocadherin 15 protein.
Length = 1684
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 500 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 556
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 557 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 613
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 614 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 668
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 669 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 726
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 727 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 780
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 781 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 839
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 840 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 894
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 895 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 935
Score = 96.7 bits (230), Expect = 6e-19
Identities = 124/475 (26%), Positives = 206/475 (43%), Gaps = 55/475 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S + + + +LD +DN+PVF S Y ++ N GT I +++A D DLG N V Y
Sbjct: 808 STLTLAIKVLDIDDNSPVFTNST-YTVLVEENLPAGTTILQIEAKDVDLGAN--VSY--- 861
Query: 501 RTSNLTITSPFKINPNTGTVSVAES------PILEGRHALFVEASDQPANPSERRYSLAV 554
R + + F ++P TG +S+ S P E VEA D +A
Sbjct: 862 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP---GIAT 918
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA----FEQNDVSY-- 608
VT+ V K P F Y+ V + GT + + DA + V Y
Sbjct: 919 VTVIV----KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 974
Query: 609 -DLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
D+ Y + F VEE SG + +L+ ++ VA + + + ++ATV ++
Sbjct: 975 DDVQFPYPASI-FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1032
Query: 668 DVNDER--GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++ + P + + + N S +Y +GN ++D
Sbjct: 1033 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN-------EED 1085
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEF------NKGVISGAGIYQVTIYIED 779
I G I+ PLD E R Y + V A+ N V S + +V I I+D
Sbjct: 1086 TFGINNIT--GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1143
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGKE 835
EN++PPVF+ Y G + E++++ T + +KATD D G ++ Y L EGKE
Sbjct: 1144 ENNHPPVFQKKFYIGGVSEDARMFTSVLR---VKATDKDTGNYSVMAYRLIIPPIKEGKE 1200
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT--GGLSSEAELIIMIGDEND 888
F V+ TG++K ++ +K ++A D GLS +A++++ + ++ D
Sbjct: 1201 GFVVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1254
Score = 87.4 bits (207), Expect = 3e-16
Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 57/480 (11%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 706 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 761
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 762 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 815
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 816 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 867
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 868 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 927
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ--DVTD 728
D V K + ++ + G I ++ + + G VR+ + + Q
Sbjct: 928 DYPPVFSKRIYKGMV--APDAVKGTPITTVYAED-ADPPGLPASRVRYRVDDVQFPYPAS 984
Query: 729 DIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPP 785
+ ED G + T+ L+ E ++++ V+A F+ G V+S + ++ + E P
Sbjct: 985 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVA-FDDGEPVMSSSATVKILVLHPGE---IP 1040
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
F Y S++ T+ M +I A N +Y++ G ++ F ++ TG
Sbjct: 1041 RFTQEEYRP--PPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1094
Query: 845 VVKFIGDSLDREKKIMYKLSLVARD---------TGGLSSEAELIIMIGDENDNKPEFNQ 895
V+ ++ LD E + Y L + A S+ A++ I I DEN++ P F +
Sbjct: 1095 VI-YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1153
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 532 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 577
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 578 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 637
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 638 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 694
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 695 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 743
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 744 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 802
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 803 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 857
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 858 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 901
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 902 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 934
Score = 67.7 bits (158), Expect = 3e-10
Identities = 38/124 (30%), Positives = 66/124 (53%), Gaps = 2/124 (1%)
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN--LQANTFVLQVQASQLNNP 284
+ ++ Y ++SGN+ F ++++ G +++ LD + + L+ L+V + L P
Sbjct: 1070 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1129
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
K+ A+V IE+ D N++ P F+ FY + E+ SVL+V ATDKD G Y+
Sbjct: 1130 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1189
Query: 345 LDDP 348
L P
Sbjct: 1190 LIIP 1193
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 652 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 705
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 706 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 764
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 765 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 800
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 742 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 793
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 794 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 853
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 854 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 891
Score = 66.1 bits (154), Expect = 9e-10
Identities = 119/479 (24%), Positives = 201/479 (41%), Gaps = 50/479 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 600 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 656
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 657 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 709
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 710 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 763
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 764 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 821
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 822 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 872
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 873 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 932
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD-EGTNA-LFMYTL----FGEGKEMFDVD 840
F Y+G + ++ GT I + A DAD G A Y + F +F+V+
Sbjct: 933 FSKRIYKGMVAPDAVKGTPI---TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 989
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
E++G V +L+ E ++KL +VA D G +SS A + I++ + P F Q E
Sbjct: 990 EDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 1046
Score = 62.1 bits (144), Expect = 1e-08
Identities = 85/331 (25%), Positives = 131/331 (39%), Gaps = 29/331 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 709 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 766
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 767 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 824
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 825 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 879
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 880 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 938
Query: 312 NISIVENLPNGFSVLQVMATDKDQG--ENGEFTYQLDD-----PKGAFSIDPRSGWLTVR 364
+ + G + V A D D Y++DD P F ++ SG + R
Sbjct: 939 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 998
Query: 365 NQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
L+ E + ++ V A + V+ + A
Sbjct: 999 --VNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1027
Score = 60.1 bits (139), Expect = 6e-08
Identities = 67/219 (30%), Positives = 98/219 (44%), Gaps = 37/219 (16%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 817 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 866
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 867 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 921
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD-FGQNANLTYFIQPSDTDLP 1092
VKD+ND+ PVF K Y V + V A DAD G A+ + + D P
Sbjct: 922 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY-RVDDVQFP 980
Query: 1093 -----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
FE+ +G + L+ E + L VVA D+G
Sbjct: 981 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1019
Score = 58.4 bits (135), Expect = 2e-07
Identities = 28/73 (38%), Positives = 45/73 (61%), Gaps = 1/73 (1%)
Query: 292 VEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ-LDDPKG 350
V I+++D NDN P F Y++ + ++ G SV+Q+ A D D+G NGE TY+ L +G
Sbjct: 502 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG 561
Query: 351 AFSIDPRSGWLTV 363
F I+ +G +T+
Sbjct: 562 DFIINKTTGLITI 574
Score = 52.8 bits (121), Expect = 9e-06
Identities = 41/160 (25%), Positives = 74/160 (46%), Gaps = 12/160 (7%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
+P+DRE++ Y ++ A F+ GV + V I + D NDN P F +Y+ ++ + +
Sbjct: 474 QPVDREEQQTYTFSITA-FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMR 530
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMY 861
G + + A DADEG+N Y + + F +++ TG++ I ++ Y
Sbjct: 531 PGDSVIQ---LTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTY 586
Query: 862 KLSLVARDTGGLSSEAELIIMIGDE-----NDNKPEFNQI 896
L++ A D + I + E N + P F Q+
Sbjct: 587 ALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQL 626
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 540 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 593
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 594 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 652
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 653 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 707
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 481 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 540
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 541 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 595
Score = 49.6 bits (113), Expect = 8e-05
Identities = 49/175 (28%), Positives = 88/175 (50%), Gaps = 26/175 (14%)
Query: 742 KPLDREKRDVYRMTVIAEFNKG--VISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMEN 799
+P++R+ + + + AE + G + + AG++ I I DEN+ P F +Y+G+I+E+
Sbjct: 351 EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLH---IEILDENNQSPYFTMPSYQGYILES 407
Query: 800 SKIGTEIKMDNI-------IKATDAD------EG--TNALFMYTLFGEGKEMFDVDENTG 844
+ +G I D++ I A D D G T ++ + +F V + TG
Sbjct: 408 APVGATIS-DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQ-TG 465
Query: 845 VVKFIG--DSLDREKKIMYKLSLVARDTGGLSSEAELI-IMIGDENDNKPEFNQI 896
+ +++ +DRE++ Y S+ A D G SE ++ I + D NDN P F +I
Sbjct: 466 ITRYLTLLQPVDREEQQTYTFSITAFD-GVQESEPVIVNIQVMDANDNTPTFPEI 519
Score = 46.8 bits (106), Expect = 6e-04
Identities = 39/130 (30%), Positives = 62/130 (47%), Gaps = 16/130 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRG 562
+T++V G
Sbjct: 249 TTLTVDVLDG 258
Score = 46.4 bits (105), Expect = 8e-04
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 10/136 (7%)
Query: 992 FVINERHGHVIVARSL--PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F + E G VI +L P + F+L + A D G ++ + +V++ V + P F +
Sbjct: 986 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ 1044
Query: 1048 TWYNFN-VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
Y V E ++G + A N ++ Y I + + F I+ +TGV+ VNG
Sbjct: 1045 EEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1100
Query: 1107 ELDRETEDKYILTVVA 1122
LD ET Y+L V A
Sbjct: 1101 PLDYETRTSYVLRVQA 1116
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 37.5 bits (83), Expect = 0.37
Identities = 51/207 (24%), Positives = 88/207 (42%), Gaps = 28/207 (13%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD 334
E+ P G ++ L+++A DKD
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKD 432
Score = 35.5 bits (78), Expect = 1.5
Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
++ V + ++D N+H PVF+K +Y V E+A+ VL +V ATD D G + + Y
Sbjct: 1132 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL-RVKATDKDTGNYSVMAYRL 1190
Query: 1083 FIQP-SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
I P + F + TG++ + V+A D+
Sbjct: 1191 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1234
>AL353784-2|CAH72389.1| 961|Homo sapiens protocadherin 15 protein.
Length = 961
Score = 139 bits (337), Expect = 6e-32
Identities = 129/461 (27%), Positives = 212/461 (45%), Gaps = 33/461 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + ++DANDN P F P Y+ + ++ + G + ++ AVD D G NG + Y++
Sbjct: 493 VIVNIQVMDANDNTPTF-PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-- 549
Query: 503 SNLTITSPFKINPNTGTVSVAES-PILEGR-HALFVEASDQPANPSERRYSLAVVTIEVT 560
+ F IN TG +++A ++ GR +AL V+A+D A P+ERR S+ V IEV
Sbjct: 550 --VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVL 606
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P P M Y + + +G + ++ D E + ++Y + +G + V F
Sbjct: 607 PPNNQSPPRFPQLM---YSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRV-F 661
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
+ E +G++T+ L R + Y A + + + V DVND V
Sbjct: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF--DP 719
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFT 740
+ P V E A A +GQ+ T+ + G V + + N ++ I +G+I+T
Sbjct: 720 YLPRNLSVVEEEANAFVGQVKATDPDA---GINGQVHYSLGNFNNL---FRITSNGSIYT 773
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
L+RE RD Y + V+A + V + I + D +DN PVF ++TY + EN
Sbjct: 774 AVKLNREVRDYYELVVVAT-DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE---- 856
GT I I+A D D G N + E K F + TG + + SLD E
Sbjct: 833 PAGTTILQ---IEAKDVDLGANVSYRIR-SPEVKHFFALHPFTGELSLL-RSLDYEAFPD 887
Query: 857 KKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQ 895
++ + A D G A + +++ D ND P F++
Sbjct: 888 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 928
Score = 84.2 bits (199), Expect = 3e-15
Identities = 112/453 (24%), Positives = 179/453 (39%), Gaps = 68/453 (15%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G ++I+L A+D D G NG+I YE + + F+IN+ G + +A
Sbjct: 525 GDSVIQLTAVDADEGSNGEITYEI--------------LVGAQGDFIINKTTGLITIAPG 570
Query: 1007 LPP--ESEFRLNISALDGG----NLNDNISVRVFVKDVNDHFPV-FKKTWYNFNVEEAQY 1059
+ + L + A D N +V + V N+ P F + Y+ + EA
Sbjct: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
VL + ATD + ++TY I+ D F +S TG+L++ LDRE+ D+YIL
Sbjct: 631 VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMI 1179
+ A D DVNDN+P FD L +E +N +
Sbjct: 688 ITASDG--RPDGTSTATVNIVVTDVNDNAP---VFDPYLPRNLSVVEEEAN------AFV 736
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTD-FIGNGNGLILYSLPQRKNQQNL----------G 1228
KAT + +A I V N + F NG I ++ + ++
Sbjct: 737 GQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
Query: 1229 LPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENF 1288
+ ST L + V D+ D + PVF + Y + +EEN+ A ++ + +
Sbjct: 796 VHPRHSTLTLAIKVLDIDD-----NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ Y I +++ F + P G L L+RS D E E +
Sbjct: 851 NVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI-------------TF 894
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A D+ M V V +KD+ND P F+
Sbjct: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
Score = 72.9 bits (171), Expect = 8e-12
Identities = 115/502 (22%), Positives = 208/502 (41%), Gaps = 65/502 (12%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVI-----GKVKAVDPDLGQNGMVLYDL 499
V + + D NDN+P F + Y ++ VGT I G A D D G NG + Y +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 500 QR-----TSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSL 552
Q TSN T P + TG + + + E R+ + ++A+D+ N +ERR +
Sbjct: 192 QYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Query: 553 AVVTIEVTRGTKGNK--------PDIPDFMGAPYEFWVGS-------NVGIGT----SVG 593
+T++V G P+ D Y+ + N I T ++
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
Query: 594 QIR-VNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVAL 650
Q R + ++ + Y +L G E P F + R+ +++++ ++R +D A
Sbjct: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
Query: 651 QENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFH-TNMSSI 708
Q+N + L + ++D N++ ++ I ++ GA I + T+ I
Sbjct: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYI--LESAPVGATISDSLNLTSPLRI 426
Query: 709 YG-----NGTGNVRF-LIANQQDVTDDIAIAEDGT---IFTQKPLDREKRDVYRMTVIAE 759
T + L N D T + + G + +P+DRE++ Y ++ A
Sbjct: 427 VALDKDIEDTKDPELHLFLN--DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA- 483
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
F+ GV + V I + D NDN P F +Y+ ++ + + G + + A DADE
Sbjct: 484 FD-GVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ---LTAVDADE 538
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G+N Y + + F +++ TG++ I ++ Y L++ A D +
Sbjct: 539 GSNGEITYEILVGAQGDFIINKTTGLIT-IAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
Query: 880 IIMIGDE-----NDNKPEFNQI 896
I + E N + P F Q+
Sbjct: 598 ICTVYIEVLPPNNQSPPRFPQL 619
Score = 68.1 bits (159), Expect = 2e-10
Identities = 72/255 (28%), Positives = 112/255 (43%), Gaps = 28/255 (10%)
Query: 441 SFVNVEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + + D NDN PVF +P NL ++NA +G+VKA DPD G NG V Y
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDAGINGQVHY 754
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVV 555
L +NL F+I N G++ A E R + L V A+D +P +LA+
Sbjct: 755 SLGNFNNL-----FRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+++ + P F + Y V N+ GT++ QI D +VSY + E
Sbjct: 809 VLDIDDNS-------PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY-RIRSPE 860
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANL-----SIVTNATVHVVDVN 670
FA+ +G ++++ L P + L E ++ + TV V D+N
Sbjct: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
Query: 671 DERGVLLKGAHSPII 685
D V K + ++
Sbjct: 921 DYPPVFSKRIYKGMV 935
Score = 66.9 bits (156), Expect = 5e-10
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 11/159 (6%)
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
G ++ Y + +G+ +++F+L G L L K LD ++ + ++L + AS P T
Sbjct: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRES-----TDRYILIITASD-GRPDGT 698
Query: 288 AQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
+ A V I + D+NDN P F+ N+S+VE N F V QV ATD D G NG+ Y L
Sbjct: 699 STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG 757
Query: 347 DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ F I ++ L+RE + V A +
Sbjct: 758 NFNNLFRITSNG---SIYTAVKLNREVRDYYELVVVATD 793
Score = 66.9 bits (156), Expect = 5e-10
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 10/160 (6%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
F + A D D G+ + Y L GN LF + S NGS++ +L+ + + +
Sbjct: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVR-----DYYE 786
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L V A+ + + + I++LD++DN P F Y + + ENLP G ++LQ+ A D
Sbjct: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
Query: 334 DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREA 373
D G N + + + K F++ P +G L++ LD EA
Sbjct: 847 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEA 884
Score = 59.7 bits (138), Expect = 8e-08
Identities = 40/150 (26%), Positives = 73/150 (48%), Gaps = 6/150 (4%)
Query: 215 PEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
P I A+D+D+ L + +F++ + +L +D E + T+
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE---EQQTYTF 479
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + ++ V I+++D NDN P F Y++ + ++ G SV+Q+ A D D
Sbjct: 480 SITA--FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Query: 335 QGENGEFTYQ-LDDPKGAFSIDPRSGWLTV 363
+G NGE TY+ L +G F I+ +G +T+
Sbjct: 538 EGSNGEITYEILVGAQGDFIINKTTGLITI 567
Score = 58.4 bits (135), Expect = 2e-07
Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 20/263 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+V + + DVNDN P+F PY + AF+ + P I V L F
Sbjct: 702 TVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 759
Query: 142 KDI-RAFDRDKPNTP---NSDV--HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
++ R T N +V +Y +V DG A+ H + L KVLD D
Sbjct: 760 NNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG--AVHPRHSTLTLAIKVLDIDDNSP 817
Query: 196 EFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNG 251
F V++ IL I A D DLG A + Y + S + F+L G
Sbjct: 818 VFTNSTYTVLVEENLPAGTTIL---QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
Query: 252 SLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY 311
L L + LD +A + +A+ L V+A + + A V + + D+ND P F Y
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFL-VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 312 NISIVENLPNGFSVLQVMATDKD 334
+ + G + V A D D
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDAD 954
Score = 56.4 bits (130), Expect = 7e-07
Identities = 94/392 (23%), Positives = 160/392 (40%), Gaps = 40/392 (10%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S V + +L N+ +P P +Y + +VG V+ ++A D + +
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSIT 649
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAV 554
Y ++ + F ++ TG +++ ++ E R+ L + ASD + + S A
Sbjct: 650 YAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGT----STAT 702
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLH 612
V I VT N P ++ P V VGQ++ D A V Y L
Sbjct: 703 VNIVVT-DVNDNAPVFDPYL--PRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL-- 756
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT-NATVHVVDVND 671
G + F + + T V L+R R Y+ VA + T + V+D++D
Sbjct: 757 GNFNNL-FRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
V ++ + V+EN AG I QI ++ NV + I + + V
Sbjct: 815 NSPVFTNSTYTVL---VEENLPAGTTILQIEAKDVDL-----GANVSYRIRSPE-VKHFF 865
Query: 731 AIAE-DGTIFTQKPLDREK---RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
A+ G + + LD E ++ ++ F+ GI VT+ ++D ND PPV
Sbjct: 866 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 925
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDAD 818
F Y+G + ++ GT I + A DAD
Sbjct: 926 FSKRIYKGMVAPDAVKGTPI---TTVYAEDAD 954
Score = 55.2 bits (127), Expect = 2e-06
Identities = 52/160 (32%), Positives = 74/160 (46%), Gaps = 30/160 (18%)
Query: 929 LDVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD+D P+F L+ EN+P GTTI+++ A D+D G N + Y S
Sbjct: 810 LDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP-------- 859
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLN--ISALD-GGNLNDNI-SVRV 1033
EVK +F ++ G + + RSL P+ E + + A D G + I +V V
Sbjct: 860 -----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDAD 1073
VKD+ND+ PVF K Y V + V A DAD
Sbjct: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/177 (24%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + YE++ G F ++ G + + +++ + T+ L VQA+
Sbjct: 533 AVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM-----IVGRTYALTVQAA 586
Query: 280 QLNNPLKTAQA--RVEIELLDLNDNLP-EFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
P + + V IE+L N+ P F Y++ I E + G +L + ATD+ +G
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-EG 645
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
++ + + DP+ F++ +G LT+ LDRE+ + + A + P T
Sbjct: 646 DSITYAIENGDPQRVFNLSETTGILTLGK--ALDRESTDRYILIITASDGRPDGTST 700
Score = 50.4 bits (115), Expect = 5e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 1010 ESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
+ + +I+A DG ++ + V + V D ND+ P F + Y+ V + ++ A
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
DAD G N +TY I F I+ TG++++ ++ Y LTV A DN
Sbjct: 534 VDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
Score = 44.8 bits (101), Expect = 0.002
Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 740 TQKPLDREK-RDVYRMTVIAE-FNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYEGFI 796
T + LDR+ +++ + V + NK V G IY +V I + D NDN P F+H +Y +
Sbjct: 99 TGRVLDRDPPMNIHSIVVQVQCINKKV--GTIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
Query: 797 MENSKIGTEI--KMDNIIKATDADEGTNALFMYTL 829
E + +GT I ATD D+G N Y +
Sbjct: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 10/104 (9%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL-----GKVDATDADFGQNANLTYFIQ 1085
VR+ V+D ND+ P FK Y V E + G ATD D G N + Y IQ
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1086 --PSD--TDLPFEIS-PLTGVLSVNGELDRETEDKYILTVVARD 1124
P D ++ FEI LTG + + L+ E + +Y + + A D
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
Score = 41.1 bits (92), Expect = 0.030
Identities = 36/114 (31%), Positives = 53/114 (46%), Gaps = 13/114 (11%)
Query: 246 LDSVNGSLFLEKE-LDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLDLNDNL 303
+D V LFL LD + + ++ V+QVQ +N + T V I + D NDN
Sbjct: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNS 144
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVM-----ATDKDQGENGEFTYQL----DDP 348
P F+ + Y ++ E P G ++ ATD D G NG+ Y + DDP
Sbjct: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDP 198
Score = 39.1 bits (87), Expect = 0.12
Identities = 17/38 (44%), Positives = 21/38 (55%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
Y V + + D NDN P F Y+ TV+ELTP G F
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF 167
Score = 38.3 bits (85), Expect = 0.21
Identities = 62/270 (22%), Positives = 111/270 (41%), Gaps = 34/270 (12%)
Query: 145 RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
RA + ++ T + + ++ G+D G L P + L Y A E + +
Sbjct: 237 RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR-----T 291
Query: 205 GKRIHKEILFPEPIHAIDQDLGVGAT-----LRYELISGNDR---KLFSLDSVNGSLFLE 256
+ ++ I+ P PI AIDQD + + Y ++ G + F + L L
Sbjct: 292 PEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL 350
Query: 257 KELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIV 316
+ ++ D F L ++A Q N A A + IE+LD N+ P F + Y I+
Sbjct: 351 EPVNRDFHQK-----FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
Query: 317 ENLPNGFSV---------LQVMATDKD--QGENGEFTYQLDDPKGAFSIDPRSGWLTVRN 365
E+ P G ++ L+++A DKD ++ E L+D F++ +
Sbjct: 406 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
Query: 366 QTVLDREAHSSLRMKVYA----KETNPSVV 391
+DRE + + A +E+ P +V
Sbjct: 466 LQPVDREEQQTYTFSITAFDGVQESEPVIV 495
>AY861435-1|AAX56125.1| 1065|Homo sapiens protocadherin 11X isoform
5 protein.
Length = 1065
Score = 138 bits (333), Expect = 2e-31
Identities = 140/517 (27%), Positives = 223/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 211 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 263
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 264 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 324 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + +++ + + ++
Sbjct: 378 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ I T +S++
Sbjct: 436 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG----IQLTKVSAM 491
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ N + D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 550
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y ++ EN + GT +I TD D G N+
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 606
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 607 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701
Score = 113 bits (273), Expect = 3e-24
Identities = 116/473 (24%), Positives = 203/473 (42%), Gaps = 23/473 (4%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+++ V + + D NDN P+F P+ + S+ N+ + + AVDPD+G NG+
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLF-PATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 497 YDLQRTSNLTITSPFKINPNTGTVS--VAESPILEGRHALFVEASDQPANPSERRYSLAV 554
Y+L ++ N+ + P + + + + +V +R S A+
Sbjct: 176 YELIKSQNIFGLDVIE-TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 234
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQN---DVSYDL 610
+ + VT T N P F E + N +GTSV Q+ DA +N S+
Sbjct: 235 LQVSVT-DTNDNH---PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN 290
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L F + +G+IT+ + L R P + +A + + V+V DVN
Sbjct: 291 LVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDGGLMPARAMVLVNVTDVN 349
Query: 671 DE-RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D + ++ +P+ V + +I ++ + G V ++
Sbjct: 350 DNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVI-AEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ + T LD E Y + ++ A+ K ++ + + + I ++DENDN PVF
Sbjct: 410 PVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKDENDNAPVFT 467
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ I EN+ G ++ + A DAD G NA Y L + F +D TG++
Sbjct: 468 QSFVTVSIPENNSPGIQLTK---VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTV 524
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
+ LDREK+ Y +++A+D G L+S + + I D+NDN P F E N
Sbjct: 525 V-KKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Score = 97.9 bits (233), Expect = 2e-19
Identities = 81/246 (32%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G + K++A+D DSG N +I Y
Sbjct: 446 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYL 504
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 505 LGPDA--PPE------------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF YNF V E +G + TD D+G N+ +T I
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 610
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 611 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 667
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 668 DNKPVF 673
Score = 77.8 bits (183), Expect = 3e-13
Identities = 157/658 (23%), Positives = 255/658 (38%), Gaps = 104/658 (15%)
Query: 770 IYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL 829
+ ++ IED NDN P+F I ENS I ++ + A D D G N + Y L
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLP---AAVDPDVGINGVQNYEL 178
Query: 830 FGE----GKEMFDVDENTGVVKFI-GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIM 882
G ++ + E + + I LDRE+K Y + + D G SS A L +
Sbjct: 179 IKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238
Query: 883 IGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPE 942
+ D NDN P F + E I N G ++ ++ A D D I E
Sbjct: 239 VTDTNDNHPVFKETE------IEVSIPENAPVGTSVTQL-----HATDAD-------IGE 280
Query: 943 NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRY-FVINERHGHV 1001
N I + +L S + ++ + N+ + K D E + ++ G +
Sbjct: 281 NAK-----IHFSFSNLVSNIARRL-FHLNATTGLITIKEPLDREETPNHKLLVLASDGGL 334
Query: 1002 IVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTR 1061
+ AR++ + ++ D + +I +R V VND + + N T+
Sbjct: 335 MPARAM-------VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN--------TK 379
Query: 1062 RVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETEDKYIL 1118
L V DAD N +T F +D ++PF + P+ +L LD E+ +Y +
Sbjct: 380 IALITVTDKDAD--HNGRVTCF---TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAI 434
Query: 1119 TVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMM 1178
++A D G D NDN+P F + PE + + M
Sbjct: 435 KLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPENNSPGIQLTKVSAM 491
Query: 1179 IPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL--------GLP 1230
+ N +G F+ D G ++ L + K + L G+P
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLD---CRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 548
Query: 1231 SLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEHYENF 1288
L+S + V++ D D + PVF Y + EN+ + V L+++ ++ +N
Sbjct: 549 PLTSNVTVFVSIIDQND-----NSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ IL+END F ID + G + S DRE +++Y V+
Sbjct: 604 AVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK-------------- 644
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAPFGYQVMQL 1404
AED KV + + DVNDN P F N +P+T P G V Q+
Sbjct: 645 ---AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQV 698
Score = 77.4 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 488 VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE-----DKYLFTIL 541
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + YN + ENLP +V + TD D G+
Sbjct: 542 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 601
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 602 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 647
Score = 76.2 bits (179), Expect = 9e-13
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 21/178 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A+D D+G+ YELI + +F LD + L ++KELD + + +T+
Sbjct: 163 AVDPDVGINGVQNYELIKSQN--IFGLDVIETPEGDKMPQLIVQKELDRE-----EKDTY 215
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V++V+ P +++ A +++ + D NDN P F+ +SI EN P G SV Q+ ATD
Sbjct: 216 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 275
Query: 333 KDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D GEN + + + + F ++ +G +T++ LDRE + ++ V A +
Sbjct: 276 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP--LDREETPNHKLLVLASD 331
Score = 67.7 bits (158), Expect = 3e-10
Identities = 82/341 (24%), Positives = 143/341 (41%), Gaps = 47/341 (13%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTV 134
++I + + IED+NDN P+F T ++++ E + K L A + P + I
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK--YTLPAAVDPDVGI--NG 172
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR-KVLDYDAG 193
+ + K F D TP D ++ + L+ K +++ KV D
Sbjct: 173 VQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE-----LDREEKDTYVMKVKVEDGGFP 227
Query: 194 DKEFQLVIMASG----------KRIHKEILFPE---------PIHAIDQDLGVGATLRYE 234
+ ++ S K E+ PE +HA D D+G A + +
Sbjct: 228 QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFS 287
Query: 235 ---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQAR 291
L+S R+LF L++ G + +++ LD + N + L V AS + L A+A
Sbjct: 288 FSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----LLVLAS--DGGLMPARAM 340
Query: 292 VEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN+P ++ + N ++V EN+P + + TDKD NG T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-F 399
Query: 346 DDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D + F + P S + LD E+ +K+ A +
Sbjct: 400 TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAAD 440
Score = 64.1 bits (149), Expect = 4e-09
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 413 SNQFLLETAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 469
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G + +V A D D G N + Y L D FS+D R+G LTV +
Sbjct: 470 FVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-- 527
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 528 LDREKEDKYLFTILAKD 544
Score = 63.3 bits (147), Expect = 6e-09
Identities = 103/485 (21%), Positives = 185/485 (38%), Gaps = 50/485 (10%)
Query: 940 IPENIPIGTTIIKLN-ALDLDSGLNGQIRYEFNSEVY-IPPSKLSADALEVKRYFVINER 997
+PEN+ IG + LN +L + L ++++ + +P ++ D E+ F R
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEI---FTTGAR 90
Query: 998 HGHVIVARSLPPESEFRLNIS-ALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ +P + + A+ + + +R ++D+ND+ P+F T N ++ E
Sbjct: 91 IDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPE 150
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGELDRE 1111
A D D G N Y + S ++ L V ELDRE
Sbjct: 151 NSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE 210
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
+D Y++ V D G D NDN P F + +E PE +
Sbjct: 211 EKDTYVMKVKVEDGG-FPQRSSTAILQVSVTDTNDNHPVFKETE--IEVSIPENAPVGT- 266
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLP----QRKNQ 1224
SV + A I ENA I + + + +N + + N GLI P + N
Sbjct: 267 ---SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 1225 QNLGLPS----LSSTAILMVTVADVPDEVEMSDKPVFISRYYE-LEIEENVNAPVELVSL 1279
+ L L S + + A+++V V DV D V D ++ + + + EN+ ++ +
Sbjct: 324 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 383
Query: 1280 NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQK 1339
+T+ + R +++ R R V ++ A
Sbjct: 384 TVTDKDADHNGRVTCFTDHEIPFRL------------------RPVFSNQFLLETAAYLD 425
Query: 1340 YSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGY 1399
Y + I +A D + + +++KD NDN+P FT + +IP G
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF--VTVSIPENNSPGI 483
Query: 1400 QVMQL 1404
Q+ ++
Sbjct: 484 QLTKV 488
Score = 58.4 bits (135), Expect = 2e-07
Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 644
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V N S LP+ G V QV+A D D
Sbjct: 645 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDND 704
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 705 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 750
Score = 52.8 bits (121), Expect = 9e-06
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ PSN YE + S GTV+ +V AVD D G N V Y
Sbjct: 655 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 714 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 768
Query: 556 TIEV 559
+ V
Sbjct: 769 NLFV 772
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/206 (24%), Positives = 93/206 (45%), Gaps = 27/206 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSLTI 130
G+ +++ ++V V I D NDN P+F Y+ V E P G I + P G + +
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 605
Query: 131 PL---------TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L T+ + + +FDR+K + + V D G + SS K
Sbjct: 606 TLSILDENDDFTIDSQTGVIRPNISFDREKQES-----YTFYVKAEDGGRVSRSSSAKVT 660
Query: 182 LLLRKVLD------YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
+ + V D + ++LV+ ++ ++F + A+D D G+ A +RY +
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT---VVFQ--VIAVDNDTGMNAEVRYSI 715
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDL 261
+ GN R LF++D G++ L ++ D+
Sbjct: 716 VGGNTRDLFAIDQETGNITLMEKCDV 741
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/114 (29%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS--LTIPLTVPRGLT 139
S T Y++ D + + VT++ + K +F++ P S L +P T P G
Sbjct: 638 SYTFYVK-AEDGGRVSRSSSAKVTINVVDVNDNKP-VFIVPPSNCSYELVLPSTNP-GTV 694
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 695 VFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 745
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
LT A D+D G NA I Y + + P F++D +G + VV L R+
Sbjct: 485 LTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 225 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 265
>AY861434-1|AAX56124.1| 1329|Homo sapiens protocadherin 11X isoform
6 protein.
Length = 1329
Score = 138 bits (333), Expect = 2e-31
Identities = 140/517 (27%), Positives = 223/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 211 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 263
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 264 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 324 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + +++ + + ++
Sbjct: 378 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ I T +S++
Sbjct: 436 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG----IQLTKVSAM 491
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ N + D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 550
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y ++ EN + GT +I TD D G N+
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 606
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 607 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701
Score = 113 bits (273), Expect = 3e-24
Identities = 116/473 (24%), Positives = 203/473 (42%), Gaps = 23/473 (4%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+++ V + + D NDN P+F P+ + S+ N+ + + AVDPD+G NG+
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLF-PATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 497 YDLQRTSNLTITSPFKINPNTGTVS--VAESPILEGRHALFVEASDQPANPSERRYSLAV 554
Y+L ++ N+ + P + + + + +V +R S A+
Sbjct: 176 YELIKSQNIFGLDVIE-TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 234
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQN---DVSYDL 610
+ + VT T N P F E + N +GTSV Q+ DA +N S+
Sbjct: 235 LQVSVT-DTNDNH---PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN 290
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L F + +G+IT+ + L R P + +A + + V+V DVN
Sbjct: 291 LVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDGGLMPARAMVLVNVTDVN 349
Query: 671 DE-RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D + ++ +P+ V + +I ++ + G V ++
Sbjct: 350 DNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVI-AEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ + T LD E Y + ++ A+ K ++ + + + I ++DENDN PVF
Sbjct: 410 PVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKDENDNAPVFT 467
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ I EN+ G ++ + A DAD G NA Y L + F +D TG++
Sbjct: 468 QSFVTVSIPENNSPGIQLTK---VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTV 524
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
+ LDREK+ Y +++A+D G L+S + + I D+NDN P F E N
Sbjct: 525 V-KKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Score = 97.9 bits (233), Expect = 2e-19
Identities = 81/246 (32%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G + K++A+D DSG N +I Y
Sbjct: 446 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYL 504
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 505 LGPDA--PPE------------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF YNF V E +G + TD D+G N+ +T I
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 610
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 611 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 667
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 668 DNKPVF 673
Score = 77.8 bits (183), Expect = 3e-13
Identities = 157/658 (23%), Positives = 255/658 (38%), Gaps = 104/658 (15%)
Query: 770 IYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL 829
+ ++ IED NDN P+F I ENS I ++ + A D D G N + Y L
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLP---AAVDPDVGINGVQNYEL 178
Query: 830 FGE----GKEMFDVDENTGVVKFI-GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIM 882
G ++ + E + + I LDRE+K Y + + D G SS A L +
Sbjct: 179 IKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238
Query: 883 IGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPE 942
+ D NDN P F + E I N G ++ ++ A D D I E
Sbjct: 239 VTDTNDNHPVFKETE------IEVSIPENAPVGTSVTQL-----HATDAD-------IGE 280
Query: 943 NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRY-FVINERHGHV 1001
N I + +L S + ++ + N+ + K D E + ++ G +
Sbjct: 281 NAK-----IHFSFSNLVSNIARRL-FHLNATTGLITIKEPLDREETPNHKLLVLASDGGL 334
Query: 1002 IVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTR 1061
+ AR++ + ++ D + +I +R V VND + + N T+
Sbjct: 335 MPARAM-------VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN--------TK 379
Query: 1062 RVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETEDKYIL 1118
L V DAD N +T F +D ++PF + P+ +L LD E+ +Y +
Sbjct: 380 IALITVTDKDAD--HNGRVTCF---TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAI 434
Query: 1119 TVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMM 1178
++A D G D NDN+P F + PE + + M
Sbjct: 435 KLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPENNSPGIQLTKVSAM 491
Query: 1179 IPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL--------GLP 1230
+ N +G F+ D G ++ L + K + L G+P
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLD---CRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 548
Query: 1231 SLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEHYENF 1288
L+S + V++ D D + PVF Y + EN+ + V L+++ ++ +N
Sbjct: 549 PLTSNVTVFVSIIDQND-----NSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ IL+END F ID + G + S DRE +++Y V+
Sbjct: 604 AVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK-------------- 644
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAPFGYQVMQL 1404
AED KV + + DVNDN P F N +P+T P G V Q+
Sbjct: 645 ---AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQV 698
Score = 77.4 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 488 VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE-----DKYLFTIL 541
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + YN + ENLP +V + TD D G+
Sbjct: 542 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 601
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 602 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 647
Score = 76.2 bits (179), Expect = 9e-13
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 21/178 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A+D D+G+ YELI + +F LD + L ++KELD + + +T+
Sbjct: 163 AVDPDVGINGVQNYELIKSQN--IFGLDVIETPEGDKMPQLIVQKELDRE-----EKDTY 215
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V++V+ P +++ A +++ + D NDN P F+ +SI EN P G SV Q+ ATD
Sbjct: 216 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 275
Query: 333 KDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D GEN + + + + F ++ +G +T++ LDRE + ++ V A +
Sbjct: 276 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP--LDREETPNHKLLVLASD 331
Score = 67.7 bits (158), Expect = 3e-10
Identities = 82/341 (24%), Positives = 143/341 (41%), Gaps = 47/341 (13%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTV 134
++I + + IED+NDN P+F T ++++ E + K L A + P + I
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK--YTLPAAVDPDVGI--NG 172
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR-KVLDYDAG 193
+ + K F D TP D ++ + L+ K +++ KV D
Sbjct: 173 VQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE-----LDREEKDTYVMKVKVEDGGFP 227
Query: 194 DKEFQLVIMASG----------KRIHKEILFPE---------PIHAIDQDLGVGATLRYE 234
+ ++ S K E+ PE +HA D D+G A + +
Sbjct: 228 QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFS 287
Query: 235 ---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQAR 291
L+S R+LF L++ G + +++ LD + N + L V AS + L A+A
Sbjct: 288 FSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----LLVLAS--DGGLMPARAM 340
Query: 292 VEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN+P ++ + N ++V EN+P + + TDKD NG T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-F 399
Query: 346 DDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D + F + P S + LD E+ +K+ A +
Sbjct: 400 TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAAD 440
Score = 64.1 bits (149), Expect = 4e-09
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 413 SNQFLLETAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 469
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G + +V A D D G N + Y L D FS+D R+G LTV +
Sbjct: 470 FVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-- 527
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 528 LDREKEDKYLFTILAKD 544
Score = 63.3 bits (147), Expect = 6e-09
Identities = 103/485 (21%), Positives = 185/485 (38%), Gaps = 50/485 (10%)
Query: 940 IPENIPIGTTIIKLN-ALDLDSGLNGQIRYEFNSEVY-IPPSKLSADALEVKRYFVINER 997
+PEN+ IG + LN +L + L ++++ + +P ++ D E+ F R
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEI---FTTGAR 90
Query: 998 HGHVIVARSLPPESEFRLNIS-ALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ +P + + A+ + + +R ++D+ND+ P+F T N ++ E
Sbjct: 91 IDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPE 150
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGELDRE 1111
A D D G N Y + S ++ L V ELDRE
Sbjct: 151 NSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE 210
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
+D Y++ V D G D NDN P F + +E PE +
Sbjct: 211 EKDTYVMKVKVEDGG-FPQRSSTAILQVSVTDTNDNHPVFKETE--IEVSIPENAPVGT- 266
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLP----QRKNQ 1224
SV + A I ENA I + + + +N + + N GLI P + N
Sbjct: 267 ---SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 1225 QNLGLPS----LSSTAILMVTVADVPDEVEMSDKPVFISRYYE-LEIEENVNAPVELVSL 1279
+ L L S + + A+++V V DV D V D ++ + + + EN+ ++ +
Sbjct: 324 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 383
Query: 1280 NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQK 1339
+T+ + R +++ R R V ++ A
Sbjct: 384 TVTDKDADHNGRVTCFTDHEIPFRL------------------RPVFSNQFLLETAAYLD 425
Query: 1340 YSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGY 1399
Y + I +A D + + +++KD NDN+P FT + +IP G
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF--VTVSIPENNSPGI 483
Query: 1400 QVMQL 1404
Q+ ++
Sbjct: 484 QLTKV 488
Score = 58.4 bits (135), Expect = 2e-07
Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 644
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V N S LP+ G V QV+A D D
Sbjct: 645 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDND 704
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 705 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 750
Score = 52.8 bits (121), Expect = 9e-06
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ PSN YE + S GTV+ +V AVD D G N V Y
Sbjct: 655 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 714 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 768
Query: 556 TIEV 559
+ V
Sbjct: 769 NLFV 772
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/206 (24%), Positives = 93/206 (45%), Gaps = 27/206 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSLTI 130
G+ +++ ++V V I D NDN P+F Y+ V E P G I + P G + +
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 605
Query: 131 PL---------TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L T+ + + +FDR+K + + V D G + SS K
Sbjct: 606 TLSILDENDDFTIDSQTGVIRPNISFDREKQES-----YTFYVKAEDGGRVSRSSSAKVT 660
Query: 182 LLLRKVLD------YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
+ + V D + ++LV+ ++ ++F + A+D D G+ A +RY +
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT---VVFQ--VIAVDNDTGMNAEVRYSI 715
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDL 261
+ GN R LF++D G++ L ++ D+
Sbjct: 716 VGGNTRDLFAIDQETGNITLMEKCDV 741
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/114 (29%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS--LTIPLTVPRGLT 139
S T Y++ D + + VT++ + K +F++ P S L +P T P G
Sbjct: 638 SYTFYVK-AEDGGRVSRSSSAKVTINVVDVNDNKP-VFIVPPSNCSYELVLPSTNP-GTV 694
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 695 VFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 745
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
LT A D+D G NA I Y + + P F++D +G + VV L R+
Sbjct: 485 LTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 225 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 265
>AY861433-1|AAX56123.1| 1310|Homo sapiens protocadherin 11X isoform
7 protein.
Length = 1310
Score = 138 bits (333), Expect = 2e-31
Identities = 140/517 (27%), Positives = 223/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 211 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 263
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 264 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 324 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + +++ + + ++
Sbjct: 378 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ I T +S++
Sbjct: 436 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG----IQLTKVSAM 491
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ N + D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 550
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y ++ EN + GT +I TD D G N+
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 606
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 607 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701
Score = 113 bits (273), Expect = 3e-24
Identities = 116/473 (24%), Positives = 203/473 (42%), Gaps = 23/473 (4%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+++ V + + D NDN P+F P+ + S+ N+ + + AVDPD+G NG+
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLF-PATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 497 YDLQRTSNLTITSPFKINPNTGTVS--VAESPILEGRHALFVEASDQPANPSERRYSLAV 554
Y+L ++ N+ + P + + + + +V +R S A+
Sbjct: 176 YELIKSQNIFGLDVIE-TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 234
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQN---DVSYDL 610
+ + VT T N P F E + N +GTSV Q+ DA +N S+
Sbjct: 235 LQVSVT-DTNDNH---PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN 290
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L F + +G+IT+ + L R P + +A + + V+V DVN
Sbjct: 291 LVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDGGLMPARAMVLVNVTDVN 349
Query: 671 DE-RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D + ++ +P+ V + +I ++ + G V ++
Sbjct: 350 DNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVI-AEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ + T LD E Y + ++ A+ K ++ + + + I ++DENDN PVF
Sbjct: 410 PVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKDENDNAPVFT 467
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ I EN+ G ++ + A DAD G NA Y L + F +D TG++
Sbjct: 468 QSFVTVSIPENNSPGIQLTK---VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTV 524
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
+ LDREK+ Y +++A+D G L+S + + I D+NDN P F E N
Sbjct: 525 V-KKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Score = 97.9 bits (233), Expect = 2e-19
Identities = 81/246 (32%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G + K++A+D DSG N +I Y
Sbjct: 446 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYL 504
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 505 LGPDA--PPE------------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF YNF V E +G + TD D+G N+ +T I
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 610
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 611 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 667
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 668 DNKPVF 673
Score = 77.8 bits (183), Expect = 3e-13
Identities = 157/658 (23%), Positives = 255/658 (38%), Gaps = 104/658 (15%)
Query: 770 IYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL 829
+ ++ IED NDN P+F I ENS I ++ + A D D G N + Y L
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLP---AAVDPDVGINGVQNYEL 178
Query: 830 FGE----GKEMFDVDENTGVVKFI-GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIM 882
G ++ + E + + I LDRE+K Y + + D G SS A L +
Sbjct: 179 IKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238
Query: 883 IGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPE 942
+ D NDN P F + E I N G ++ ++ A D D I E
Sbjct: 239 VTDTNDNHPVFKETE------IEVSIPENAPVGTSVTQL-----HATDAD-------IGE 280
Query: 943 NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRY-FVINERHGHV 1001
N I + +L S + ++ + N+ + K D E + ++ G +
Sbjct: 281 NAK-----IHFSFSNLVSNIARRL-FHLNATTGLITIKEPLDREETPNHKLLVLASDGGL 334
Query: 1002 IVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTR 1061
+ AR++ + ++ D + +I +R V VND + + N T+
Sbjct: 335 MPARAM-------VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN--------TK 379
Query: 1062 RVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETEDKYIL 1118
L V DAD N +T F +D ++PF + P+ +L LD E+ +Y +
Sbjct: 380 IALITVTDKDAD--HNGRVTCF---TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAI 434
Query: 1119 TVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMM 1178
++A D G D NDN+P F + PE + + M
Sbjct: 435 KLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPENNSPGIQLTKVSAM 491
Query: 1179 IPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL--------GLP 1230
+ N +G F+ D G ++ L + K + L G+P
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLD---CRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 548
Query: 1231 SLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEHYENF 1288
L+S + V++ D D + PVF Y + EN+ + V L+++ ++ +N
Sbjct: 549 PLTSNVTVFVSIIDQND-----NSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ IL+END F ID + G + S DRE +++Y V+
Sbjct: 604 AVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK-------------- 644
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAPFGYQVMQL 1404
AED KV + + DVNDN P F N +P+T P G V Q+
Sbjct: 645 ---AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQV 698
Score = 77.4 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 488 VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE-----DKYLFTIL 541
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + YN + ENLP +V + TD D G+
Sbjct: 542 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 601
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 602 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 647
Score = 76.2 bits (179), Expect = 9e-13
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 21/178 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A+D D+G+ YELI + +F LD + L ++KELD + + +T+
Sbjct: 163 AVDPDVGINGVQNYELIKSQN--IFGLDVIETPEGDKMPQLIVQKELDRE-----EKDTY 215
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V++V+ P +++ A +++ + D NDN P F+ +SI EN P G SV Q+ ATD
Sbjct: 216 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 275
Query: 333 KDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D GEN + + + + F ++ +G +T++ LDRE + ++ V A +
Sbjct: 276 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP--LDREETPNHKLLVLASD 331
Score = 67.7 bits (158), Expect = 3e-10
Identities = 82/341 (24%), Positives = 143/341 (41%), Gaps = 47/341 (13%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTV 134
++I + + IED+NDN P+F T ++++ E + K L A + P + I
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK--YTLPAAVDPDVGI--NG 172
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR-KVLDYDAG 193
+ + K F D TP D ++ + L+ K +++ KV D
Sbjct: 173 VQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE-----LDREEKDTYVMKVKVEDGGFP 227
Query: 194 DKEFQLVIMASG----------KRIHKEILFPE---------PIHAIDQDLGVGATLRYE 234
+ ++ S K E+ PE +HA D D+G A + +
Sbjct: 228 QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFS 287
Query: 235 ---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQAR 291
L+S R+LF L++ G + +++ LD + N + L V AS + L A+A
Sbjct: 288 FSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----LLVLAS--DGGLMPARAM 340
Query: 292 VEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN+P ++ + N ++V EN+P + + TDKD NG T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-F 399
Query: 346 DDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D + F + P S + LD E+ +K+ A +
Sbjct: 400 TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAAD 440
Score = 64.1 bits (149), Expect = 4e-09
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 413 SNQFLLETAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 469
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G + +V A D D G N + Y L D FS+D R+G LTV +
Sbjct: 470 FVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-- 527
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 528 LDREKEDKYLFTILAKD 544
Score = 63.3 bits (147), Expect = 6e-09
Identities = 103/485 (21%), Positives = 185/485 (38%), Gaps = 50/485 (10%)
Query: 940 IPENIPIGTTIIKLN-ALDLDSGLNGQIRYEFNSEVY-IPPSKLSADALEVKRYFVINER 997
+PEN+ IG + LN +L + L ++++ + +P ++ D E+ F R
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEI---FTTGAR 90
Query: 998 HGHVIVARSLPPESEFRLNIS-ALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ +P + + A+ + + +R ++D+ND+ P+F T N ++ E
Sbjct: 91 IDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPE 150
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGELDRE 1111
A D D G N Y + S ++ L V ELDRE
Sbjct: 151 NSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE 210
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
+D Y++ V D G D NDN P F + +E PE +
Sbjct: 211 EKDTYVMKVKVEDGG-FPQRSSTAILQVSVTDTNDNHPVFKETE--IEVSIPENAPVGT- 266
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLP----QRKNQ 1224
SV + A I ENA I + + + +N + + N GLI P + N
Sbjct: 267 ---SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 1225 QNLGLPS----LSSTAILMVTVADVPDEVEMSDKPVFISRYYE-LEIEENVNAPVELVSL 1279
+ L L S + + A+++V V DV D V D ++ + + + EN+ ++ +
Sbjct: 324 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 383
Query: 1280 NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQK 1339
+T+ + R +++ R R V ++ A
Sbjct: 384 TVTDKDADHNGRVTCFTDHEIPFRL------------------RPVFSNQFLLETAAYLD 425
Query: 1340 YSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGY 1399
Y + I +A D + + +++KD NDN+P FT + +IP G
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF--VTVSIPENNSPGI 483
Query: 1400 QVMQL 1404
Q+ ++
Sbjct: 484 QLTKV 488
Score = 58.4 bits (135), Expect = 2e-07
Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 644
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V N S LP+ G V QV+A D D
Sbjct: 645 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDND 704
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 705 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 750
Score = 52.8 bits (121), Expect = 9e-06
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ PSN YE + S GTV+ +V AVD D G N V Y
Sbjct: 655 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 714 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 768
Query: 556 TIEV 559
+ V
Sbjct: 769 NLFV 772
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/206 (24%), Positives = 93/206 (45%), Gaps = 27/206 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSLTI 130
G+ +++ ++V V I D NDN P+F Y+ V E P G I + P G + +
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 605
Query: 131 PL---------TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L T+ + + +FDR+K + + V D G + SS K
Sbjct: 606 TLSILDENDDFTIDSQTGVIRPNISFDREKQES-----YTFYVKAEDGGRVSRSSSAKVT 660
Query: 182 LLLRKVLD------YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
+ + V D + ++LV+ ++ ++F + A+D D G+ A +RY +
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT---VVFQ--VIAVDNDTGMNAEVRYSI 715
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDL 261
+ GN R LF++D G++ L ++ D+
Sbjct: 716 VGGNTRDLFAIDQETGNITLMEKCDV 741
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/114 (29%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS--LTIPLTVPRGLT 139
S T Y++ D + + VT++ + K +F++ P S L +P T P G
Sbjct: 638 SYTFYVK-AEDGGRVSRSSSAKVTINVVDVNDNKP-VFIVPPSNCSYELVLPSTNP-GTV 694
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 695 VFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 745
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
LT A D+D G NA I Y + + P F++D +G + VV L R+
Sbjct: 485 LTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 225 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 265
>AY861432-1|AAX56122.1| 1339|Homo sapiens protocadherin 11X isoform
8 protein.
Length = 1339
Score = 138 bits (333), Expect = 2e-31
Identities = 140/517 (27%), Positives = 223/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 211 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 263
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 264 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 324 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + +++ + + ++
Sbjct: 378 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ I T +S++
Sbjct: 436 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG----IQLTKVSAM 491
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ N + D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 550
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y ++ EN + GT +I TD D G N+
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 606
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 607 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701
Score = 113 bits (273), Expect = 3e-24
Identities = 116/473 (24%), Positives = 203/473 (42%), Gaps = 23/473 (4%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+++ V + + D NDN P+F P+ + S+ N+ + + AVDPD+G NG+
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLF-PATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 497 YDLQRTSNLTITSPFKINPNTGTVS--VAESPILEGRHALFVEASDQPANPSERRYSLAV 554
Y+L ++ N+ + P + + + + +V +R S A+
Sbjct: 176 YELIKSQNIFGLDVIE-TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 234
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQN---DVSYDL 610
+ + VT T N P F E + N +GTSV Q+ DA +N S+
Sbjct: 235 LQVSVT-DTNDNH---PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN 290
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L F + +G+IT+ + L R P + +A + + V+V DVN
Sbjct: 291 LVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDGGLMPARAMVLVNVTDVN 349
Query: 671 DE-RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D + ++ +P+ V + +I ++ + G V ++
Sbjct: 350 DNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVI-AEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ + T LD E Y + ++ A+ K ++ + + + I ++DENDN PVF
Sbjct: 410 PVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKDENDNAPVFT 467
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ I EN+ G ++ + A DAD G NA Y L + F +D TG++
Sbjct: 468 QSFVTVSIPENNSPGIQLTK---VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTV 524
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
+ LDREK+ Y +++A+D G L+S + + I D+NDN P F E N
Sbjct: 525 V-KKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Score = 97.9 bits (233), Expect = 2e-19
Identities = 81/246 (32%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G + K++A+D DSG N +I Y
Sbjct: 446 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYL 504
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 505 LGPDA--PPE------------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF YNF V E +G + TD D+G N+ +T I
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 610
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 611 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 667
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 668 DNKPVF 673
Score = 77.8 bits (183), Expect = 3e-13
Identities = 157/658 (23%), Positives = 255/658 (38%), Gaps = 104/658 (15%)
Query: 770 IYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL 829
+ ++ IED NDN P+F I ENS I ++ + A D D G N + Y L
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLP---AAVDPDVGINGVQNYEL 178
Query: 830 FGE----GKEMFDVDENTGVVKFI-GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIM 882
G ++ + E + + I LDRE+K Y + + D G SS A L +
Sbjct: 179 IKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238
Query: 883 IGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPE 942
+ D NDN P F + E I N G ++ ++ A D D I E
Sbjct: 239 VTDTNDNHPVFKETE------IEVSIPENAPVGTSVTQL-----HATDAD-------IGE 280
Query: 943 NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRY-FVINERHGHV 1001
N I + +L S + ++ + N+ + K D E + ++ G +
Sbjct: 281 NAK-----IHFSFSNLVSNIARRL-FHLNATTGLITIKEPLDREETPNHKLLVLASDGGL 334
Query: 1002 IVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTR 1061
+ AR++ + ++ D + +I +R V VND + + N T+
Sbjct: 335 MPARAM-------VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN--------TK 379
Query: 1062 RVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETEDKYIL 1118
L V DAD N +T F +D ++PF + P+ +L LD E+ +Y +
Sbjct: 380 IALITVTDKDAD--HNGRVTCF---TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAI 434
Query: 1119 TVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMM 1178
++A D G D NDN+P F + PE + + M
Sbjct: 435 KLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPENNSPGIQLTKVSAM 491
Query: 1179 IPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL--------GLP 1230
+ N +G F+ D G ++ L + K + L G+P
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLD---CRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 548
Query: 1231 SLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEHYENF 1288
L+S + V++ D D + PVF Y + EN+ + V L+++ ++ +N
Sbjct: 549 PLTSNVTVFVSIIDQND-----NSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ IL+END F ID + G + S DRE +++Y V+
Sbjct: 604 AVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK-------------- 644
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAPFGYQVMQL 1404
AED KV + + DVNDN P F N +P+T P G V Q+
Sbjct: 645 ---AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQV 698
Score = 77.4 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 488 VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE-----DKYLFTIL 541
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + YN + ENLP +V + TD D G+
Sbjct: 542 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 601
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 602 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 647
Score = 76.2 bits (179), Expect = 9e-13
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 21/178 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A+D D+G+ YELI + +F LD + L ++KELD + + +T+
Sbjct: 163 AVDPDVGINGVQNYELIKSQN--IFGLDVIETPEGDKMPQLIVQKELDRE-----EKDTY 215
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V++V+ P +++ A +++ + D NDN P F+ +SI EN P G SV Q+ ATD
Sbjct: 216 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 275
Query: 333 KDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D GEN + + + + F ++ +G +T++ LDRE + ++ V A +
Sbjct: 276 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP--LDREETPNHKLLVLASD 331
Score = 67.7 bits (158), Expect = 3e-10
Identities = 82/341 (24%), Positives = 143/341 (41%), Gaps = 47/341 (13%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTV 134
++I + + IED+NDN P+F T ++++ E + K L A + P + I
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK--YTLPAAVDPDVGI--NG 172
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR-KVLDYDAG 193
+ + K F D TP D ++ + L+ K +++ KV D
Sbjct: 173 VQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE-----LDREEKDTYVMKVKVEDGGFP 227
Query: 194 DKEFQLVIMASG----------KRIHKEILFPE---------PIHAIDQDLGVGATLRYE 234
+ ++ S K E+ PE +HA D D+G A + +
Sbjct: 228 QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFS 287
Query: 235 ---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQAR 291
L+S R+LF L++ G + +++ LD + N + L V AS + L A+A
Sbjct: 288 FSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----LLVLAS--DGGLMPARAM 340
Query: 292 VEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN+P ++ + N ++V EN+P + + TDKD NG T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-F 399
Query: 346 DDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D + F + P S + LD E+ +K+ A +
Sbjct: 400 TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAAD 440
Score = 64.1 bits (149), Expect = 4e-09
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 413 SNQFLLETAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 469
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G + +V A D D G N + Y L D FS+D R+G LTV +
Sbjct: 470 FVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-- 527
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 528 LDREKEDKYLFTILAKD 544
Score = 63.3 bits (147), Expect = 6e-09
Identities = 103/485 (21%), Positives = 185/485 (38%), Gaps = 50/485 (10%)
Query: 940 IPENIPIGTTIIKLN-ALDLDSGLNGQIRYEFNSEVY-IPPSKLSADALEVKRYFVINER 997
+PEN+ IG + LN +L + L ++++ + +P ++ D E+ F R
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEI---FTTGAR 90
Query: 998 HGHVIVARSLPPESEFRLNIS-ALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ +P + + A+ + + +R ++D+ND+ P+F T N ++ E
Sbjct: 91 IDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPE 150
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGELDRE 1111
A D D G N Y + S ++ L V ELDRE
Sbjct: 151 NSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE 210
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
+D Y++ V D G D NDN P F + +E PE +
Sbjct: 211 EKDTYVMKVKVEDGG-FPQRSSTAILQVSVTDTNDNHPVFKETE--IEVSIPENAPVGT- 266
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLP----QRKNQ 1224
SV + A I ENA I + + + +N + + N GLI P + N
Sbjct: 267 ---SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 1225 QNLGLPS----LSSTAILMVTVADVPDEVEMSDKPVFISRYYE-LEIEENVNAPVELVSL 1279
+ L L S + + A+++V V DV D V D ++ + + + EN+ ++ +
Sbjct: 324 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 383
Query: 1280 NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQK 1339
+T+ + R +++ R R V ++ A
Sbjct: 384 TVTDKDADHNGRVTCFTDHEIPFRL------------------RPVFSNQFLLETAAYLD 425
Query: 1340 YSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGY 1399
Y + I +A D + + +++KD NDN+P FT + +IP G
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF--VTVSIPENNSPGI 483
Query: 1400 QVMQL 1404
Q+ ++
Sbjct: 484 QLTKV 488
Score = 58.4 bits (135), Expect = 2e-07
Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 644
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V N S LP+ G V QV+A D D
Sbjct: 645 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDND 704
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 705 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 750
Score = 52.8 bits (121), Expect = 9e-06
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ PSN YE + S GTV+ +V AVD D G N V Y
Sbjct: 655 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 714 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 768
Query: 556 TIEV 559
+ V
Sbjct: 769 NLFV 772
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/206 (24%), Positives = 93/206 (45%), Gaps = 27/206 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSLTI 130
G+ +++ ++V V I D NDN P+F Y+ V E P G I + P G + +
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 605
Query: 131 PL---------TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L T+ + + +FDR+K + + V D G + SS K
Sbjct: 606 TLSILDENDDFTIDSQTGVIRPNISFDREKQES-----YTFYVKAEDGGRVSRSSSAKVT 660
Query: 182 LLLRKVLD------YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
+ + V D + ++LV+ ++ ++F + A+D D G+ A +RY +
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT---VVFQ--VIAVDNDTGMNAEVRYSI 715
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDL 261
+ GN R LF++D G++ L ++ D+
Sbjct: 716 VGGNTRDLFAIDQETGNITLMEKCDV 741
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/114 (29%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS--LTIPLTVPRGLT 139
S T Y++ D + + VT++ + K +F++ P S L +P T P G
Sbjct: 638 SYTFYVK-AEDGGRVSRSSSAKVTINVVDVNDNKP-VFIVPPSNCSYELVLPSTNP-GTV 694
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 695 VFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 745
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
LT A D+D G NA I Y + + P F++D +G + VV L R+
Sbjct: 485 LTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 225 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 265
>AL133321-2|CAI41436.1| 1337|Homo sapiens protocadherin 11 X-linked
protein.
Length = 1337
Score = 138 bits (333), Expect = 2e-31
Identities = 140/517 (27%), Positives = 223/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 211 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 263
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 264 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 324 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + +++ + + ++
Sbjct: 378 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ I T +S++
Sbjct: 436 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG----IQLTKVSAM 491
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ N + D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 550
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y ++ EN + GT +I TD D G N+
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 606
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 607 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701
Score = 113 bits (273), Expect = 3e-24
Identities = 116/473 (24%), Positives = 203/473 (42%), Gaps = 23/473 (4%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+++ V + + D NDN P+F P+ + S+ N+ + + AVDPD+G NG+
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLF-PATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 497 YDLQRTSNLTITSPFKINPNTGTVS--VAESPILEGRHALFVEASDQPANPSERRYSLAV 554
Y+L ++ N+ + P + + + + +V +R S A+
Sbjct: 176 YELIKSQNIFGLDVIE-TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 234
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQN---DVSYDL 610
+ + VT T N P F E + N +GTSV Q+ DA +N S+
Sbjct: 235 LQVSVT-DTNDNH---PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN 290
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L F + +G+IT+ + L R P + +A + + V+V DVN
Sbjct: 291 LVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDGGLMPARAMVLVNVTDVN 349
Query: 671 DE-RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D + ++ +P+ V + +I ++ + G V ++
Sbjct: 350 DNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVI-AEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ + T LD E Y + ++ A+ K ++ + + + I ++DENDN PVF
Sbjct: 410 PVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKDENDNAPVFT 467
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ I EN+ G ++ + A DAD G NA Y L + F +D TG++
Sbjct: 468 QSFVTVSIPENNSPGIQLTK---VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTV 524
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
+ LDREK+ Y +++A+D G L+S + + I D+NDN P F E N
Sbjct: 525 V-KKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Score = 97.9 bits (233), Expect = 2e-19
Identities = 81/246 (32%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G + K++A+D DSG N +I Y
Sbjct: 446 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYL 504
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 505 LGPDA--PPE------------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF YNF V E +G + TD D+G N+ +T I
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 610
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 611 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 667
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 668 DNKPVF 673
Score = 77.8 bits (183), Expect = 3e-13
Identities = 157/658 (23%), Positives = 255/658 (38%), Gaps = 104/658 (15%)
Query: 770 IYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL 829
+ ++ IED NDN P+F I ENS I ++ + A D D G N + Y L
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLP---AAVDPDVGINGVQNYEL 178
Query: 830 FGE----GKEMFDVDENTGVVKFI-GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIM 882
G ++ + E + + I LDRE+K Y + + D G SS A L +
Sbjct: 179 IKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238
Query: 883 IGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPE 942
+ D NDN P F + E I N G ++ ++ A D D I E
Sbjct: 239 VTDTNDNHPVFKETE------IEVSIPENAPVGTSVTQL-----HATDAD-------IGE 280
Query: 943 NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRY-FVINERHGHV 1001
N I + +L S + ++ + N+ + K D E + ++ G +
Sbjct: 281 NAK-----IHFSFSNLVSNIARRL-FHLNATTGLITIKEPLDREETPNHKLLVLASDGGL 334
Query: 1002 IVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTR 1061
+ AR++ + ++ D + +I +R V VND + + N T+
Sbjct: 335 MPARAM-------VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN--------TK 379
Query: 1062 RVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETEDKYIL 1118
L V DAD N +T F +D ++PF + P+ +L LD E+ +Y +
Sbjct: 380 IALITVTDKDAD--HNGRVTCF---TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAI 434
Query: 1119 TVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMM 1178
++A D G D NDN+P F + PE + + M
Sbjct: 435 KLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPENNSPGIQLTKVSAM 491
Query: 1179 IPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL--------GLP 1230
+ N +G F+ D G ++ L + K + L G+P
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLD---CRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 548
Query: 1231 SLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEHYENF 1288
L+S + V++ D D + PVF Y + EN+ + V L+++ ++ +N
Sbjct: 549 PLTSNVTVFVSIIDQND-----NSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ IL+END F ID + G + S DRE +++Y V+
Sbjct: 604 AVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK-------------- 644
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAPFGYQVMQL 1404
AED KV + + DVNDN P F N +P+T P G V Q+
Sbjct: 645 ---AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQV 698
Score = 77.4 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 488 VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE-----DKYLFTIL 541
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + YN + ENLP +V + TD D G+
Sbjct: 542 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 601
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 602 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 647
Score = 76.2 bits (179), Expect = 9e-13
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 21/178 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A+D D+G+ YELI + +F LD + L ++KELD + + +T+
Sbjct: 163 AVDPDVGINGVQNYELIKSQN--IFGLDVIETPEGDKMPQLIVQKELDRE-----EKDTY 215
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V++V+ P +++ A +++ + D NDN P F+ +SI EN P G SV Q+ ATD
Sbjct: 216 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 275
Query: 333 KDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D GEN + + + + F ++ +G +T++ LDRE + ++ V A +
Sbjct: 276 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP--LDREETPNHKLLVLASD 331
Score = 67.7 bits (158), Expect = 3e-10
Identities = 82/341 (24%), Positives = 143/341 (41%), Gaps = 47/341 (13%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTV 134
++I + + IED+NDN P+F T ++++ E + K L A + P + I
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK--YTLPAAVDPDVGI--NG 172
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR-KVLDYDAG 193
+ + K F D TP D ++ + L+ K +++ KV D
Sbjct: 173 VQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE-----LDREEKDTYVMKVKVEDGGFP 227
Query: 194 DKEFQLVIMASG----------KRIHKEILFPE---------PIHAIDQDLGVGATLRYE 234
+ ++ S K E+ PE +HA D D+G A + +
Sbjct: 228 QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFS 287
Query: 235 ---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQAR 291
L+S R+LF L++ G + +++ LD + N + L V AS + L A+A
Sbjct: 288 FSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----LLVLAS--DGGLMPARAM 340
Query: 292 VEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN+P ++ + N ++V EN+P + + TDKD NG T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-F 399
Query: 346 DDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D + F + P S + LD E+ +K+ A +
Sbjct: 400 TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAAD 440
Score = 64.1 bits (149), Expect = 4e-09
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 413 SNQFLLETAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 469
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G + +V A D D G N + Y L D FS+D R+G LTV +
Sbjct: 470 FVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-- 527
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 528 LDREKEDKYLFTILAKD 544
Score = 63.3 bits (147), Expect = 6e-09
Identities = 103/485 (21%), Positives = 185/485 (38%), Gaps = 50/485 (10%)
Query: 940 IPENIPIGTTIIKLN-ALDLDSGLNGQIRYEFNSEVY-IPPSKLSADALEVKRYFVINER 997
+PEN+ IG + LN +L + L ++++ + +P ++ D E+ F R
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEI---FTTGAR 90
Query: 998 HGHVIVARSLPPESEFRLNIS-ALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ +P + + A+ + + +R ++D+ND+ P+F T N ++ E
Sbjct: 91 IDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPE 150
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGELDRE 1111
A D D G N Y + S ++ L V ELDRE
Sbjct: 151 NSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE 210
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
+D Y++ V D G D NDN P F + +E PE +
Sbjct: 211 EKDTYVMKVKVEDGG-FPQRSSTAILQVSVTDTNDNHPVFKETE--IEVSIPENAPVGT- 266
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLP----QRKNQ 1224
SV + A I ENA I + + + +N + + N GLI P + N
Sbjct: 267 ---SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 1225 QNLGLPS----LSSTAILMVTVADVPDEVEMSDKPVFISRYYE-LEIEENVNAPVELVSL 1279
+ L L S + + A+++V V DV D V D ++ + + + EN+ ++ +
Sbjct: 324 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 383
Query: 1280 NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQK 1339
+T+ + R +++ R R V ++ A
Sbjct: 384 TVTDKDADHNGRVTCFTDHEIPFRL------------------RPVFSNQFLLETAAYLD 425
Query: 1340 YSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGY 1399
Y + I +A D + + +++KD NDN+P FT + +IP G
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF--VTVSIPENNSPGI 483
Query: 1400 QVMQL 1404
Q+ ++
Sbjct: 484 QLTKV 488
Score = 58.4 bits (135), Expect = 2e-07
Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 644
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V N S LP+ G V QV+A D D
Sbjct: 645 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDND 704
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 705 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 750
Score = 52.8 bits (121), Expect = 9e-06
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ PSN YE + S GTV+ +V AVD D G N V Y
Sbjct: 655 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 714 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 768
Query: 556 TIEV 559
+ V
Sbjct: 769 NLFV 772
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/206 (24%), Positives = 93/206 (45%), Gaps = 27/206 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSLTI 130
G+ +++ ++V V I D NDN P+F Y+ V E P G I + P G + +
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 605
Query: 131 PL---------TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L T+ + + +FDR+K + + V D G + SS K
Sbjct: 606 TLSILDENDDFTIDSQTGVIRPNISFDREKQES-----YTFYVKAEDGGRVSRSSSAKVT 660
Query: 182 LLLRKVLD------YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
+ + V D + ++LV+ ++ ++F + A+D D G+ A +RY +
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT---VVFQ--VIAVDNDTGMNAEVRYSI 715
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDL 261
+ GN R LF++D G++ L ++ D+
Sbjct: 716 VGGNTRDLFAIDQETGNITLMEKCDV 741
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/114 (29%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS--LTIPLTVPRGLT 139
S T Y++ D + + VT++ + K +F++ P S L +P T P G
Sbjct: 638 SYTFYVK-AEDGGRVSRSSSAKVTINVVDVNDNKP-VFIVPPSNCSYELVLPSTNP-GTV 694
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 695 VFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 745
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
LT A D+D G NA I Y + + P F++D +G + VV L R+
Sbjct: 485 LTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 225 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 265
>AL133321-1|CAI41435.1| 1347|Homo sapiens protocadherin 11 X-linked
protein.
Length = 1347
Score = 138 bits (333), Expect = 2e-31
Identities = 140/517 (27%), Positives = 223/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 211 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 263
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 264 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 324 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + +++ + + ++
Sbjct: 378 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ I T +S++
Sbjct: 436 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG----IQLTKVSAM 491
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ N + D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 550
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y ++ EN + GT +I TD D G N+
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 606
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 607 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701
Score = 113 bits (273), Expect = 3e-24
Identities = 116/473 (24%), Positives = 203/473 (42%), Gaps = 23/473 (4%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+++ V + + D NDN P+F P+ + S+ N+ + + AVDPD+G NG+
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLF-PATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 497 YDLQRTSNLTITSPFKINPNTGTVS--VAESPILEGRHALFVEASDQPANPSERRYSLAV 554
Y+L ++ N+ + P + + + + +V +R S A+
Sbjct: 176 YELIKSQNIFGLDVIE-TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 234
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQN---DVSYDL 610
+ + VT T N P F E + N +GTSV Q+ DA +N S+
Sbjct: 235 LQVSVT-DTNDNH---PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN 290
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L F + +G+IT+ + L R P + +A + + V+V DVN
Sbjct: 291 LVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDGGLMPARAMVLVNVTDVN 349
Query: 671 DE-RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D + ++ +P+ V + +I ++ + G V ++
Sbjct: 350 DNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVI-AEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ + T LD E Y + ++ A+ K ++ + + + I ++DENDN PVF
Sbjct: 410 PVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKDENDNAPVFT 467
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ I EN+ G ++ + A DAD G NA Y L + F +D TG++
Sbjct: 468 QSFVTVSIPENNSPGIQLTK---VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTV 524
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
+ LDREK+ Y +++A+D G L+S + + I D+NDN P F E N
Sbjct: 525 V-KKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Score = 97.9 bits (233), Expect = 2e-19
Identities = 81/246 (32%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G + K++A+D DSG N +I Y
Sbjct: 446 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYL 504
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 505 LGPDA--PPE------------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF YNF V E +G + TD D+G N+ +T I
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 610
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 611 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 667
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 668 DNKPVF 673
Score = 77.8 bits (183), Expect = 3e-13
Identities = 157/658 (23%), Positives = 255/658 (38%), Gaps = 104/658 (15%)
Query: 770 IYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL 829
+ ++ IED NDN P+F I ENS I ++ + A D D G N + Y L
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLP---AAVDPDVGINGVQNYEL 178
Query: 830 FGE----GKEMFDVDENTGVVKFI-GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIM 882
G ++ + E + + I LDRE+K Y + + D G SS A L +
Sbjct: 179 IKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238
Query: 883 IGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPE 942
+ D NDN P F + E I N G ++ ++ A D D I E
Sbjct: 239 VTDTNDNHPVFKETE------IEVSIPENAPVGTSVTQL-----HATDAD-------IGE 280
Query: 943 NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRY-FVINERHGHV 1001
N I + +L S + ++ + N+ + K D E + ++ G +
Sbjct: 281 NAK-----IHFSFSNLVSNIARRL-FHLNATTGLITIKEPLDREETPNHKLLVLASDGGL 334
Query: 1002 IVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTR 1061
+ AR++ + ++ D + +I +R V VND + + N T+
Sbjct: 335 MPARAM-------VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN--------TK 379
Query: 1062 RVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETEDKYIL 1118
L V DAD N +T F +D ++PF + P+ +L LD E+ +Y +
Sbjct: 380 IALITVTDKDAD--HNGRVTCF---TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAI 434
Query: 1119 TVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMM 1178
++A D G D NDN+P F + PE + + M
Sbjct: 435 KLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPENNSPGIQLTKVSAM 491
Query: 1179 IPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL--------GLP 1230
+ N +G F+ D G ++ L + K + L G+P
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLD---CRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 548
Query: 1231 SLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEHYENF 1288
L+S + V++ D D + PVF Y + EN+ + V L+++ ++ +N
Sbjct: 549 PLTSNVTVFVSIIDQND-----NSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ IL+END F ID + G + S DRE +++Y V+
Sbjct: 604 AVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK-------------- 644
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAPFGYQVMQL 1404
AED KV + + DVNDN P F N +P+T P G V Q+
Sbjct: 645 ---AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQV 698
Score = 77.4 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 488 VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE-----DKYLFTIL 541
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + YN + ENLP +V + TD D G+
Sbjct: 542 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 601
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 602 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 647
Score = 76.2 bits (179), Expect = 9e-13
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 21/178 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A+D D+G+ YELI + +F LD + L ++KELD + + +T+
Sbjct: 163 AVDPDVGINGVQNYELIKSQN--IFGLDVIETPEGDKMPQLIVQKELDRE-----EKDTY 215
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V++V+ P +++ A +++ + D NDN P F+ +SI EN P G SV Q+ ATD
Sbjct: 216 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 275
Query: 333 KDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D GEN + + + + F ++ +G +T++ LDRE + ++ V A +
Sbjct: 276 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP--LDREETPNHKLLVLASD 331
Score = 67.7 bits (158), Expect = 3e-10
Identities = 82/341 (24%), Positives = 143/341 (41%), Gaps = 47/341 (13%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTV 134
++I + + IED+NDN P+F T ++++ E + K L A + P + I
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK--YTLPAAVDPDVGI--NG 172
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR-KVLDYDAG 193
+ + K F D TP D ++ + L+ K +++ KV D
Sbjct: 173 VQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE-----LDREEKDTYVMKVKVEDGGFP 227
Query: 194 DKEFQLVIMASG----------KRIHKEILFPE---------PIHAIDQDLGVGATLRYE 234
+ ++ S K E+ PE +HA D D+G A + +
Sbjct: 228 QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFS 287
Query: 235 ---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQAR 291
L+S R+LF L++ G + +++ LD + N + L V AS + L A+A
Sbjct: 288 FSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----LLVLAS--DGGLMPARAM 340
Query: 292 VEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN+P ++ + N ++V EN+P + + TDKD NG T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-F 399
Query: 346 DDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D + F + P S + LD E+ +K+ A +
Sbjct: 400 TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAAD 440
Score = 64.1 bits (149), Expect = 4e-09
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 413 SNQFLLETAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 469
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G + +V A D D G N + Y L D FS+D R+G LTV +
Sbjct: 470 FVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-- 527
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 528 LDREKEDKYLFTILAKD 544
Score = 63.3 bits (147), Expect = 6e-09
Identities = 103/485 (21%), Positives = 185/485 (38%), Gaps = 50/485 (10%)
Query: 940 IPENIPIGTTIIKLN-ALDLDSGLNGQIRYEFNSEVY-IPPSKLSADALEVKRYFVINER 997
+PEN+ IG + LN +L + L ++++ + +P ++ D E+ F R
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEI---FTTGAR 90
Query: 998 HGHVIVARSLPPESEFRLNIS-ALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ +P + + A+ + + +R ++D+ND+ P+F T N ++ E
Sbjct: 91 IDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPE 150
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGELDRE 1111
A D D G N Y + S ++ L V ELDRE
Sbjct: 151 NSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE 210
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
+D Y++ V D G D NDN P F + +E PE +
Sbjct: 211 EKDTYVMKVKVEDGG-FPQRSSTAILQVSVTDTNDNHPVFKETE--IEVSIPENAPVGT- 266
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLP----QRKNQ 1224
SV + A I ENA I + + + +N + + N GLI P + N
Sbjct: 267 ---SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 1225 QNLGLPS----LSSTAILMVTVADVPDEVEMSDKPVFISRYYE-LEIEENVNAPVELVSL 1279
+ L L S + + A+++V V DV D V D ++ + + + EN+ ++ +
Sbjct: 324 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 383
Query: 1280 NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQK 1339
+T+ + R +++ R R V ++ A
Sbjct: 384 TVTDKDADHNGRVTCFTDHEIPFRL------------------RPVFSNQFLLETAAYLD 425
Query: 1340 YSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGY 1399
Y + I +A D + + +++KD NDN+P FT + +IP G
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF--VTVSIPENNSPGI 483
Query: 1400 QVMQL 1404
Q+ ++
Sbjct: 484 QLTKV 488
Score = 58.4 bits (135), Expect = 2e-07
Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 644
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V N S LP+ G V QV+A D D
Sbjct: 645 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDND 704
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 705 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 750
Score = 52.8 bits (121), Expect = 9e-06
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ PSN YE + S GTV+ +V AVD D G N V Y
Sbjct: 655 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 714 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 768
Query: 556 TIEV 559
+ V
Sbjct: 769 NLFV 772
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/206 (24%), Positives = 93/206 (45%), Gaps = 27/206 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSLTI 130
G+ +++ ++V V I D NDN P+F Y+ V E P G I + P G + +
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 605
Query: 131 PL---------TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L T+ + + +FDR+K + + V D G + SS K
Sbjct: 606 TLSILDENDDFTIDSQTGVIRPNISFDREKQES-----YTFYVKAEDGGRVSRSSSAKVT 660
Query: 182 LLLRKVLD------YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
+ + V D + ++LV+ ++ ++F + A+D D G+ A +RY +
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT---VVFQ--VIAVDNDTGMNAEVRYSI 715
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDL 261
+ GN R LF++D G++ L ++ D+
Sbjct: 716 VGGNTRDLFAIDQETGNITLMEKCDV 741
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/114 (29%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS--LTIPLTVPRGLT 139
S T Y++ D + + VT++ + K +F++ P S L +P T P G
Sbjct: 638 SYTFYVK-AEDGGRVSRSSSAKVTINVVDVNDNKP-VFIVPPSNCSYELVLPSTNP-GTV 694
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 695 VFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 745
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
LT A D+D G NA I Y + + P F++D +G + VV L R+
Sbjct: 485 LTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 225 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 265
>AL133274-3|CAI41629.1| 1310|Homo sapiens protocadherin 11 X-linked
protein.
Length = 1310
Score = 138 bits (333), Expect = 2e-31
Identities = 140/517 (27%), Positives = 223/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 211 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 263
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 264 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 324 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + +++ + + ++
Sbjct: 378 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ I T +S++
Sbjct: 436 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG----IQLTKVSAM 491
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ N + D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 550
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y ++ EN + GT +I TD D G N+
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 606
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 607 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701
Score = 113 bits (273), Expect = 3e-24
Identities = 116/473 (24%), Positives = 203/473 (42%), Gaps = 23/473 (4%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+++ V + + D NDN P+F P+ + S+ N+ + + AVDPD+G NG+
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLF-PATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 497 YDLQRTSNLTITSPFKINPNTGTVS--VAESPILEGRHALFVEASDQPANPSERRYSLAV 554
Y+L ++ N+ + P + + + + +V +R S A+
Sbjct: 176 YELIKSQNIFGLDVIE-TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 234
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQN---DVSYDL 610
+ + VT T N P F E + N +GTSV Q+ DA +N S+
Sbjct: 235 LQVSVT-DTNDNH---PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN 290
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L F + +G+IT+ + L R P + +A + + V+V DVN
Sbjct: 291 LVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDGGLMPARAMVLVNVTDVN 349
Query: 671 DE-RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D + ++ +P+ V + +I ++ + G V ++
Sbjct: 350 DNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVI-AEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ + T LD E Y + ++ A+ K ++ + + + I ++DENDN PVF
Sbjct: 410 PVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKDENDNAPVFT 467
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ I EN+ G ++ + A DAD G NA Y L + F +D TG++
Sbjct: 468 QSFVTVSIPENNSPGIQLTK---VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTV 524
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
+ LDREK+ Y +++A+D G L+S + + I D+NDN P F E N
Sbjct: 525 V-KKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Score = 97.9 bits (233), Expect = 2e-19
Identities = 81/246 (32%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G + K++A+D DSG N +I Y
Sbjct: 446 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYL 504
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 505 LGPDA--PPE------------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF YNF V E +G + TD D+G N+ +T I
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 610
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 611 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 667
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 668 DNKPVF 673
Score = 77.8 bits (183), Expect = 3e-13
Identities = 157/658 (23%), Positives = 255/658 (38%), Gaps = 104/658 (15%)
Query: 770 IYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL 829
+ ++ IED NDN P+F I ENS I ++ + A D D G N + Y L
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLP---AAVDPDVGINGVQNYEL 178
Query: 830 FGE----GKEMFDVDENTGVVKFI-GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIM 882
G ++ + E + + I LDRE+K Y + + D G SS A L +
Sbjct: 179 IKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238
Query: 883 IGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPE 942
+ D NDN P F + E I N G ++ ++ A D D I E
Sbjct: 239 VTDTNDNHPVFKETE------IEVSIPENAPVGTSVTQL-----HATDAD-------IGE 280
Query: 943 NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRY-FVINERHGHV 1001
N I + +L S + ++ + N+ + K D E + ++ G +
Sbjct: 281 NAK-----IHFSFSNLVSNIARRL-FHLNATTGLITIKEPLDREETPNHKLLVLASDGGL 334
Query: 1002 IVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTR 1061
+ AR++ + ++ D + +I +R V VND + + N T+
Sbjct: 335 MPARAM-------VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN--------TK 379
Query: 1062 RVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETEDKYIL 1118
L V DAD N +T F +D ++PF + P+ +L LD E+ +Y +
Sbjct: 380 IALITVTDKDAD--HNGRVTCF---TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAI 434
Query: 1119 TVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMM 1178
++A D G D NDN+P F + PE + + M
Sbjct: 435 KLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPENNSPGIQLTKVSAM 491
Query: 1179 IPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL--------GLP 1230
+ N +G F+ D G ++ L + K + L G+P
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLD---CRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 548
Query: 1231 SLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEHYENF 1288
L+S + V++ D D + PVF Y + EN+ + V L+++ ++ +N
Sbjct: 549 PLTSNVTVFVSIIDQND-----NSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ IL+END F ID + G + S DRE +++Y V+
Sbjct: 604 AVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK-------------- 644
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAPFGYQVMQL 1404
AED KV + + DVNDN P F N +P+T P G V Q+
Sbjct: 645 ---AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQV 698
Score = 77.4 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 488 VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE-----DKYLFTIL 541
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + YN + ENLP +V + TD D G+
Sbjct: 542 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 601
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 602 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 647
Score = 76.2 bits (179), Expect = 9e-13
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 21/178 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A+D D+G+ YELI + +F LD + L ++KELD + + +T+
Sbjct: 163 AVDPDVGINGVQNYELIKSQN--IFGLDVIETPEGDKMPQLIVQKELDRE-----EKDTY 215
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V++V+ P +++ A +++ + D NDN P F+ +SI EN P G SV Q+ ATD
Sbjct: 216 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 275
Query: 333 KDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D GEN + + + + F ++ +G +T++ LDRE + ++ V A +
Sbjct: 276 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP--LDREETPNHKLLVLASD 331
Score = 67.7 bits (158), Expect = 3e-10
Identities = 82/341 (24%), Positives = 143/341 (41%), Gaps = 47/341 (13%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTV 134
++I + + IED+NDN P+F T ++++ E + K L A + P + I
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK--YTLPAAVDPDVGI--NG 172
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR-KVLDYDAG 193
+ + K F D TP D ++ + L+ K +++ KV D
Sbjct: 173 VQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE-----LDREEKDTYVMKVKVEDGGFP 227
Query: 194 DKEFQLVIMASG----------KRIHKEILFPE---------PIHAIDQDLGVGATLRYE 234
+ ++ S K E+ PE +HA D D+G A + +
Sbjct: 228 QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFS 287
Query: 235 ---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQAR 291
L+S R+LF L++ G + +++ LD + N + L V AS + L A+A
Sbjct: 288 FSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----LLVLAS--DGGLMPARAM 340
Query: 292 VEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN+P ++ + N ++V EN+P + + TDKD NG T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-F 399
Query: 346 DDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D + F + P S + LD E+ +K+ A +
Sbjct: 400 TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAAD 440
Score = 64.1 bits (149), Expect = 4e-09
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 413 SNQFLLETAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 469
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G + +V A D D G N + Y L D FS+D R+G LTV +
Sbjct: 470 FVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-- 527
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 528 LDREKEDKYLFTILAKD 544
Score = 63.3 bits (147), Expect = 6e-09
Identities = 103/485 (21%), Positives = 185/485 (38%), Gaps = 50/485 (10%)
Query: 940 IPENIPIGTTIIKLN-ALDLDSGLNGQIRYEFNSEVY-IPPSKLSADALEVKRYFVINER 997
+PEN+ IG + LN +L + L ++++ + +P ++ D E+ F R
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEI---FTTGAR 90
Query: 998 HGHVIVARSLPPESEFRLNIS-ALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ +P + + A+ + + +R ++D+ND+ P+F T N ++ E
Sbjct: 91 IDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPE 150
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGELDRE 1111
A D D G N Y + S ++ L V ELDRE
Sbjct: 151 NSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE 210
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
+D Y++ V D G D NDN P F + +E PE +
Sbjct: 211 EKDTYVMKVKVEDGG-FPQRSSTAILQVSVTDTNDNHPVFKETE--IEVSIPENAPVGT- 266
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLP----QRKNQ 1224
SV + A I ENA I + + + +N + + N GLI P + N
Sbjct: 267 ---SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 1225 QNLGLPS----LSSTAILMVTVADVPDEVEMSDKPVFISRYYE-LEIEENVNAPVELVSL 1279
+ L L S + + A+++V V DV D V D ++ + + + EN+ ++ +
Sbjct: 324 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 383
Query: 1280 NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQK 1339
+T+ + R +++ R R V ++ A
Sbjct: 384 TVTDKDADHNGRVTCFTDHEIPFRL------------------RPVFSNQFLLETAAYLD 425
Query: 1340 YSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGY 1399
Y + I +A D + + +++KD NDN+P FT + +IP G
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF--VTVSIPENNSPGI 483
Query: 1400 QVMQL 1404
Q+ ++
Sbjct: 484 QLTKV 488
Score = 58.4 bits (135), Expect = 2e-07
Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 644
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V N S LP+ G V QV+A D D
Sbjct: 645 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDND 704
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 705 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 750
Score = 52.8 bits (121), Expect = 9e-06
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ PSN YE + S GTV+ +V AVD D G N V Y
Sbjct: 655 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 714 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 768
Query: 556 TIEV 559
+ V
Sbjct: 769 NLFV 772
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/206 (24%), Positives = 93/206 (45%), Gaps = 27/206 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSLTI 130
G+ +++ ++V V I D NDN P+F Y+ V E P G I + P G + +
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 605
Query: 131 PL---------TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L T+ + + +FDR+K + + V D G + SS K
Sbjct: 606 TLSILDENDDFTIDSQTGVIRPNISFDREKQES-----YTFYVKAEDGGRVSRSSSAKVT 660
Query: 182 LLLRKVLD------YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
+ + V D + ++LV+ ++ ++F + A+D D G+ A +RY +
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT---VVFQ--VIAVDNDTGMNAEVRYSI 715
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDL 261
+ GN R LF++D G++ L ++ D+
Sbjct: 716 VGGNTRDLFAIDQETGNITLMEKCDV 741
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/114 (29%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS--LTIPLTVPRGLT 139
S T Y++ D + + VT++ + K +F++ P S L +P T P G
Sbjct: 638 SYTFYVK-AEDGGRVSRSSSAKVTINVVDVNDNKP-VFIVPPSNCSYELVLPSTNP-GTV 694
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 695 VFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 745
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
LT A D+D G NA I Y + + P F++D +G + VV L R+
Sbjct: 485 LTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 225 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 265
>AL133274-2|CAI41631.1| 1337|Homo sapiens protocadherin 11 X-linked
protein.
Length = 1337
Score = 138 bits (333), Expect = 2e-31
Identities = 140/517 (27%), Positives = 223/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 211 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 263
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 264 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 324 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + +++ + + ++
Sbjct: 378 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ I T +S++
Sbjct: 436 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG----IQLTKVSAM 491
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ N + D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 550
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y ++ EN + GT +I TD D G N+
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 606
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 607 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701
Score = 113 bits (273), Expect = 3e-24
Identities = 116/473 (24%), Positives = 203/473 (42%), Gaps = 23/473 (4%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+++ V + + D NDN P+F P+ + S+ N+ + + AVDPD+G NG+
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLF-PATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 497 YDLQRTSNLTITSPFKINPNTGTVS--VAESPILEGRHALFVEASDQPANPSERRYSLAV 554
Y+L ++ N+ + P + + + + +V +R S A+
Sbjct: 176 YELIKSQNIFGLDVIE-TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 234
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQN---DVSYDL 610
+ + VT T N P F E + N +GTSV Q+ DA +N S+
Sbjct: 235 LQVSVT-DTNDNH---PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN 290
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L F + +G+IT+ + L R P + +A + + V+V DVN
Sbjct: 291 LVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDGGLMPARAMVLVNVTDVN 349
Query: 671 DE-RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D + ++ +P+ V + +I ++ + G V ++
Sbjct: 350 DNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVI-AEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ + T LD E Y + ++ A+ K ++ + + + I ++DENDN PVF
Sbjct: 410 PVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKDENDNAPVFT 467
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ I EN+ G ++ + A DAD G NA Y L + F +D TG++
Sbjct: 468 QSFVTVSIPENNSPGIQLTK---VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTV 524
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
+ LDREK+ Y +++A+D G L+S + + I D+NDN P F E N
Sbjct: 525 V-KKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Score = 97.9 bits (233), Expect = 2e-19
Identities = 81/246 (32%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G + K++A+D DSG N +I Y
Sbjct: 446 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYL 504
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 505 LGPDA--PPE------------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF YNF V E +G + TD D+G N+ +T I
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 610
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 611 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 667
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 668 DNKPVF 673
Score = 77.8 bits (183), Expect = 3e-13
Identities = 157/658 (23%), Positives = 255/658 (38%), Gaps = 104/658 (15%)
Query: 770 IYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL 829
+ ++ IED NDN P+F I ENS I ++ + A D D G N + Y L
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLP---AAVDPDVGINGVQNYEL 178
Query: 830 FGE----GKEMFDVDENTGVVKFI-GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIM 882
G ++ + E + + I LDRE+K Y + + D G SS A L +
Sbjct: 179 IKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238
Query: 883 IGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPE 942
+ D NDN P F + E I N G ++ ++ A D D I E
Sbjct: 239 VTDTNDNHPVFKETE------IEVSIPENAPVGTSVTQL-----HATDAD-------IGE 280
Query: 943 NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRY-FVINERHGHV 1001
N I + +L S + ++ + N+ + K D E + ++ G +
Sbjct: 281 NAK-----IHFSFSNLVSNIARRL-FHLNATTGLITIKEPLDREETPNHKLLVLASDGGL 334
Query: 1002 IVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTR 1061
+ AR++ + ++ D + +I +R V VND + + N T+
Sbjct: 335 MPARAM-------VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN--------TK 379
Query: 1062 RVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETEDKYIL 1118
L V DAD N +T F +D ++PF + P+ +L LD E+ +Y +
Sbjct: 380 IALITVTDKDAD--HNGRVTCF---TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAI 434
Query: 1119 TVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMM 1178
++A D G D NDN+P F + PE + + M
Sbjct: 435 KLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPENNSPGIQLTKVSAM 491
Query: 1179 IPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL--------GLP 1230
+ N +G F+ D G ++ L + K + L G+P
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLD---CRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 548
Query: 1231 SLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEHYENF 1288
L+S + V++ D D + PVF Y + EN+ + V L+++ ++ +N
Sbjct: 549 PLTSNVTVFVSIIDQND-----NSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ IL+END F ID + G + S DRE +++Y V+
Sbjct: 604 AVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK-------------- 644
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAPFGYQVMQL 1404
AED KV + + DVNDN P F N +P+T P G V Q+
Sbjct: 645 ---AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQV 698
Score = 77.4 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 488 VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE-----DKYLFTIL 541
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + YN + ENLP +V + TD D G+
Sbjct: 542 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 601
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 602 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 647
Score = 76.2 bits (179), Expect = 9e-13
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 21/178 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A+D D+G+ YELI + +F LD + L ++KELD + + +T+
Sbjct: 163 AVDPDVGINGVQNYELIKSQN--IFGLDVIETPEGDKMPQLIVQKELDRE-----EKDTY 215
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V++V+ P +++ A +++ + D NDN P F+ +SI EN P G SV Q+ ATD
Sbjct: 216 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 275
Query: 333 KDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D GEN + + + + F ++ +G +T++ LDRE + ++ V A +
Sbjct: 276 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP--LDREETPNHKLLVLASD 331
Score = 67.7 bits (158), Expect = 3e-10
Identities = 82/341 (24%), Positives = 143/341 (41%), Gaps = 47/341 (13%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTV 134
++I + + IED+NDN P+F T ++++ E + K L A + P + I
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK--YTLPAAVDPDVGI--NG 172
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR-KVLDYDAG 193
+ + K F D TP D ++ + L+ K +++ KV D
Sbjct: 173 VQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE-----LDREEKDTYVMKVKVEDGGFP 227
Query: 194 DKEFQLVIMASG----------KRIHKEILFPE---------PIHAIDQDLGVGATLRYE 234
+ ++ S K E+ PE +HA D D+G A + +
Sbjct: 228 QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFS 287
Query: 235 ---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQAR 291
L+S R+LF L++ G + +++ LD + N + L V AS + L A+A
Sbjct: 288 FSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----LLVLAS--DGGLMPARAM 340
Query: 292 VEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN+P ++ + N ++V EN+P + + TDKD NG T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-F 399
Query: 346 DDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D + F + P S + LD E+ +K+ A +
Sbjct: 400 TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAAD 440
Score = 64.1 bits (149), Expect = 4e-09
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 413 SNQFLLETAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 469
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G + +V A D D G N + Y L D FS+D R+G LTV +
Sbjct: 470 FVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-- 527
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 528 LDREKEDKYLFTILAKD 544
Score = 63.3 bits (147), Expect = 6e-09
Identities = 103/485 (21%), Positives = 185/485 (38%), Gaps = 50/485 (10%)
Query: 940 IPENIPIGTTIIKLN-ALDLDSGLNGQIRYEFNSEVY-IPPSKLSADALEVKRYFVINER 997
+PEN+ IG + LN +L + L ++++ + +P ++ D E+ F R
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEI---FTTGAR 90
Query: 998 HGHVIVARSLPPESEFRLNIS-ALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ +P + + A+ + + +R ++D+ND+ P+F T N ++ E
Sbjct: 91 IDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPE 150
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGELDRE 1111
A D D G N Y + S ++ L V ELDRE
Sbjct: 151 NSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE 210
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
+D Y++ V D G D NDN P F + +E PE +
Sbjct: 211 EKDTYVMKVKVEDGG-FPQRSSTAILQVSVTDTNDNHPVFKETE--IEVSIPENAPVGT- 266
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLP----QRKNQ 1224
SV + A I ENA I + + + +N + + N GLI P + N
Sbjct: 267 ---SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 1225 QNLGLPS----LSSTAILMVTVADVPDEVEMSDKPVFISRYYE-LEIEENVNAPVELVSL 1279
+ L L S + + A+++V V DV D V D ++ + + + EN+ ++ +
Sbjct: 324 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 383
Query: 1280 NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQK 1339
+T+ + R +++ R R V ++ A
Sbjct: 384 TVTDKDADHNGRVTCFTDHEIPFRL------------------RPVFSNQFLLETAAYLD 425
Query: 1340 YSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGY 1399
Y + I +A D + + +++KD NDN+P FT + +IP G
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF--VTVSIPENNSPGI 483
Query: 1400 QVMQL 1404
Q+ ++
Sbjct: 484 QLTKV 488
Score = 58.4 bits (135), Expect = 2e-07
Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 644
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V N S LP+ G V QV+A D D
Sbjct: 645 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDND 704
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 705 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 750
Score = 52.8 bits (121), Expect = 9e-06
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ PSN YE + S GTV+ +V AVD D G N V Y
Sbjct: 655 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 714 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 768
Query: 556 TIEV 559
+ V
Sbjct: 769 NLFV 772
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/206 (24%), Positives = 93/206 (45%), Gaps = 27/206 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSLTI 130
G+ +++ ++V V I D NDN P+F Y+ V E P G I + P G + +
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 605
Query: 131 PL---------TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L T+ + + +FDR+K + + V D G + SS K
Sbjct: 606 TLSILDENDDFTIDSQTGVIRPNISFDREKQES-----YTFYVKAEDGGRVSRSSSAKVT 660
Query: 182 LLLRKVLD------YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
+ + V D + ++LV+ ++ ++F + A+D D G+ A +RY +
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT---VVFQ--VIAVDNDTGMNAEVRYSI 715
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDL 261
+ GN R LF++D G++ L ++ D+
Sbjct: 716 VGGNTRDLFAIDQETGNITLMEKCDV 741
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/114 (29%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS--LTIPLTVPRGLT 139
S T Y++ D + + VT++ + K +F++ P S L +P T P G
Sbjct: 638 SYTFYVK-AEDGGRVSRSSSAKVTINVVDVNDNKP-VFIVPPSNCSYELVLPSTNP-GTV 694
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 695 VFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 745
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
LT A D+D G NA I Y + + P F++D +G + VV L R+
Sbjct: 485 LTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 225 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 265
>AL133274-1|CAI41630.1| 1347|Homo sapiens protocadherin 11 X-linked
protein.
Length = 1347
Score = 138 bits (333), Expect = 2e-31
Identities = 140/517 (27%), Positives = 223/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 211 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 263
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 264 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 324 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + +++ + + ++
Sbjct: 378 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ I T +S++
Sbjct: 436 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG----IQLTKVSAM 491
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ N + D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 550
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y ++ EN + GT +I TD D G N+
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 606
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 607 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701
Score = 113 bits (273), Expect = 3e-24
Identities = 116/473 (24%), Positives = 203/473 (42%), Gaps = 23/473 (4%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+++ V + + D NDN P+F P+ + S+ N+ + + AVDPD+G NG+
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLF-PATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 497 YDLQRTSNLTITSPFKINPNTGTVS--VAESPILEGRHALFVEASDQPANPSERRYSLAV 554
Y+L ++ N+ + P + + + + +V +R S A+
Sbjct: 176 YELIKSQNIFGLDVIE-TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 234
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQN---DVSYDL 610
+ + VT T N P F E + N +GTSV Q+ DA +N S+
Sbjct: 235 LQVSVT-DTNDNH---PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN 290
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L F + +G+IT+ + L R P + +A + + V+V DVN
Sbjct: 291 LVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDGGLMPARAMVLVNVTDVN 349
Query: 671 DE-RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D + ++ +P+ V + +I ++ + G V ++
Sbjct: 350 DNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVI-AEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ + T LD E Y + ++ A+ K ++ + + + I ++DENDN PVF
Sbjct: 410 PVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKDENDNAPVFT 467
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ I EN+ G ++ + A DAD G NA Y L + F +D TG++
Sbjct: 468 QSFVTVSIPENNSPGIQLTK---VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTV 524
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
+ LDREK+ Y +++A+D G L+S + + I D+NDN P F E N
Sbjct: 525 V-KKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Score = 97.9 bits (233), Expect = 2e-19
Identities = 81/246 (32%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G + K++A+D DSG N +I Y
Sbjct: 446 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYL 504
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 505 LGPDA--PPE------------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF YNF V E +G + TD D+G N+ +T I
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 610
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 611 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 667
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 668 DNKPVF 673
Score = 77.8 bits (183), Expect = 3e-13
Identities = 157/658 (23%), Positives = 255/658 (38%), Gaps = 104/658 (15%)
Query: 770 IYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL 829
+ ++ IED NDN P+F I ENS I ++ + A D D G N + Y L
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLP---AAVDPDVGINGVQNYEL 178
Query: 830 FGE----GKEMFDVDENTGVVKFI-GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIM 882
G ++ + E + + I LDRE+K Y + + D G SS A L +
Sbjct: 179 IKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238
Query: 883 IGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPE 942
+ D NDN P F + E I N G ++ ++ A D D I E
Sbjct: 239 VTDTNDNHPVFKETE------IEVSIPENAPVGTSVTQL-----HATDAD-------IGE 280
Query: 943 NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRY-FVINERHGHV 1001
N I + +L S + ++ + N+ + K D E + ++ G +
Sbjct: 281 NAK-----IHFSFSNLVSNIARRL-FHLNATTGLITIKEPLDREETPNHKLLVLASDGGL 334
Query: 1002 IVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTR 1061
+ AR++ + ++ D + +I +R V VND + + N T+
Sbjct: 335 MPARAM-------VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN--------TK 379
Query: 1062 RVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETEDKYIL 1118
L V DAD N +T F +D ++PF + P+ +L LD E+ +Y +
Sbjct: 380 IALITVTDKDAD--HNGRVTCF---TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAI 434
Query: 1119 TVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMM 1178
++A D G D NDN+P F + PE + + M
Sbjct: 435 KLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPENNSPGIQLTKVSAM 491
Query: 1179 IPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL--------GLP 1230
+ N +G F+ D G ++ L + K + L G+P
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLD---CRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 548
Query: 1231 SLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEHYENF 1288
L+S + V++ D D + PVF Y + EN+ + V L+++ ++ +N
Sbjct: 549 PLTSNVTVFVSIIDQND-----NSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ IL+END F ID + G + S DRE +++Y V+
Sbjct: 604 AVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK-------------- 644
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAPFGYQVMQL 1404
AED KV + + DVNDN P F N +P+T P G V Q+
Sbjct: 645 ---AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQV 698
Score = 77.4 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 488 VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE-----DKYLFTIL 541
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + YN + ENLP +V + TD D G+
Sbjct: 542 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 601
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 602 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 647
Score = 76.2 bits (179), Expect = 9e-13
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 21/178 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A+D D+G+ YELI + +F LD + L ++KELD + + +T+
Sbjct: 163 AVDPDVGINGVQNYELIKSQN--IFGLDVIETPEGDKMPQLIVQKELDRE-----EKDTY 215
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V++V+ P +++ A +++ + D NDN P F+ +SI EN P G SV Q+ ATD
Sbjct: 216 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 275
Query: 333 KDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D GEN + + + + F ++ +G +T++ LDRE + ++ V A +
Sbjct: 276 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP--LDREETPNHKLLVLASD 331
Score = 67.7 bits (158), Expect = 3e-10
Identities = 82/341 (24%), Positives = 143/341 (41%), Gaps = 47/341 (13%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTV 134
++I + + IED+NDN P+F T ++++ E + K L A + P + I
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK--YTLPAAVDPDVGI--NG 172
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR-KVLDYDAG 193
+ + K F D TP D ++ + L+ K +++ KV D
Sbjct: 173 VQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE-----LDREEKDTYVMKVKVEDGGFP 227
Query: 194 DKEFQLVIMASG----------KRIHKEILFPE---------PIHAIDQDLGVGATLRYE 234
+ ++ S K E+ PE +HA D D+G A + +
Sbjct: 228 QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFS 287
Query: 235 ---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQAR 291
L+S R+LF L++ G + +++ LD + N + L V AS + L A+A
Sbjct: 288 FSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----LLVLAS--DGGLMPARAM 340
Query: 292 VEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN+P ++ + N ++V EN+P + + TDKD NG T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-F 399
Query: 346 DDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D + F + P S + LD E+ +K+ A +
Sbjct: 400 TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAAD 440
Score = 64.1 bits (149), Expect = 4e-09
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 413 SNQFLLETAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 469
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G + +V A D D G N + Y L D FS+D R+G LTV +
Sbjct: 470 FVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-- 527
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 528 LDREKEDKYLFTILAKD 544
Score = 63.3 bits (147), Expect = 6e-09
Identities = 103/485 (21%), Positives = 185/485 (38%), Gaps = 50/485 (10%)
Query: 940 IPENIPIGTTIIKLN-ALDLDSGLNGQIRYEFNSEVY-IPPSKLSADALEVKRYFVINER 997
+PEN+ IG + LN +L + L ++++ + +P ++ D E+ F R
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEI---FTTGAR 90
Query: 998 HGHVIVARSLPPESEFRLNIS-ALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ +P + + A+ + + +R ++D+ND+ P+F T N ++ E
Sbjct: 91 IDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPE 150
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGELDRE 1111
A D D G N Y + S ++ L V ELDRE
Sbjct: 151 NSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE 210
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
+D Y++ V D G D NDN P F + +E PE +
Sbjct: 211 EKDTYVMKVKVEDGG-FPQRSSTAILQVSVTDTNDNHPVFKETE--IEVSIPENAPVGT- 266
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLP----QRKNQ 1224
SV + A I ENA I + + + +N + + N GLI P + N
Sbjct: 267 ---SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 1225 QNLGLPS----LSSTAILMVTVADVPDEVEMSDKPVFISRYYE-LEIEENVNAPVELVSL 1279
+ L L S + + A+++V V DV D V D ++ + + + EN+ ++ +
Sbjct: 324 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 383
Query: 1280 NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQK 1339
+T+ + R +++ R R V ++ A
Sbjct: 384 TVTDKDADHNGRVTCFTDHEIPFRL------------------RPVFSNQFLLETAAYLD 425
Query: 1340 YSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGY 1399
Y + I +A D + + +++KD NDN+P FT + +IP G
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF--VTVSIPENNSPGI 483
Query: 1400 QVMQL 1404
Q+ ++
Sbjct: 484 QLTKV 488
Score = 58.4 bits (135), Expect = 2e-07
Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 644
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V N S LP+ G V QV+A D D
Sbjct: 645 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDND 704
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 705 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 750
Score = 52.8 bits (121), Expect = 9e-06
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ PSN YE + S GTV+ +V AVD D G N V Y
Sbjct: 655 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 714 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 768
Query: 556 TIEV 559
+ V
Sbjct: 769 NLFV 772
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/206 (24%), Positives = 93/206 (45%), Gaps = 27/206 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSLTI 130
G+ +++ ++V V I D NDN P+F Y+ V E P G I + P G + +
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 605
Query: 131 PL---------TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L T+ + + +FDR+K + + V D G + SS K
Sbjct: 606 TLSILDENDDFTIDSQTGVIRPNISFDREKQES-----YTFYVKAEDGGRVSRSSSAKVT 660
Query: 182 LLLRKVLD------YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
+ + V D + ++LV+ ++ ++F + A+D D G+ A +RY +
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT---VVFQ--VIAVDNDTGMNAEVRYSI 715
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDL 261
+ GN R LF++D G++ L ++ D+
Sbjct: 716 VGGNTRDLFAIDQETGNITLMEKCDV 741
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/114 (29%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS--LTIPLTVPRGLT 139
S T Y++ D + + VT++ + K +F++ P S L +P T P G
Sbjct: 638 SYTFYVK-AEDGGRVSRSSSAKVTINVVDVNDNKP-VFIVPPSNCSYELVLPSTNP-GTV 694
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 695 VFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 745
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
LT A D+D G NA I Y + + P F++D +G + VV L R+
Sbjct: 485 LTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 225 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 265
>AL121869-5|CAI41414.1| 1337|Homo sapiens protocadherin 11 X-linked
protein.
Length = 1337
Score = 138 bits (333), Expect = 2e-31
Identities = 140/517 (27%), Positives = 223/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 211 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 263
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 264 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 324 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + +++ + + ++
Sbjct: 378 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ I T +S++
Sbjct: 436 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG----IQLTKVSAM 491
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ N + D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 550
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y ++ EN + GT +I TD D G N+
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 606
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 607 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701
Score = 113 bits (273), Expect = 3e-24
Identities = 116/473 (24%), Positives = 203/473 (42%), Gaps = 23/473 (4%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+++ V + + D NDN P+F P+ + S+ N+ + + AVDPD+G NG+
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLF-PATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 497 YDLQRTSNLTITSPFKINPNTGTVS--VAESPILEGRHALFVEASDQPANPSERRYSLAV 554
Y+L ++ N+ + P + + + + +V +R S A+
Sbjct: 176 YELIKSQNIFGLDVIE-TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 234
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQN---DVSYDL 610
+ + VT T N P F E + N +GTSV Q+ DA +N S+
Sbjct: 235 LQVSVT-DTNDNH---PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN 290
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L F + +G+IT+ + L R P + +A + + V+V DVN
Sbjct: 291 LVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDGGLMPARAMVLVNVTDVN 349
Query: 671 DE-RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D + ++ +P+ V + +I ++ + G V ++
Sbjct: 350 DNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVI-AEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ + T LD E Y + ++ A+ K ++ + + + I ++DENDN PVF
Sbjct: 410 PVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKDENDNAPVFT 467
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ I EN+ G ++ + A DAD G NA Y L + F +D TG++
Sbjct: 468 QSFVTVSIPENNSPGIQLTK---VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTV 524
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
+ LDREK+ Y +++A+D G L+S + + I D+NDN P F E N
Sbjct: 525 V-KKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Score = 97.9 bits (233), Expect = 2e-19
Identities = 81/246 (32%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G + K++A+D DSG N +I Y
Sbjct: 446 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYL 504
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 505 LGPDA--PPE------------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF YNF V E +G + TD D+G N+ +T I
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 610
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 611 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 667
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 668 DNKPVF 673
Score = 77.8 bits (183), Expect = 3e-13
Identities = 157/658 (23%), Positives = 255/658 (38%), Gaps = 104/658 (15%)
Query: 770 IYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL 829
+ ++ IED NDN P+F I ENS I ++ + A D D G N + Y L
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLP---AAVDPDVGINGVQNYEL 178
Query: 830 FGE----GKEMFDVDENTGVVKFI-GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIM 882
G ++ + E + + I LDRE+K Y + + D G SS A L +
Sbjct: 179 IKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238
Query: 883 IGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPE 942
+ D NDN P F + E I N G ++ ++ A D D I E
Sbjct: 239 VTDTNDNHPVFKETE------IEVSIPENAPVGTSVTQL-----HATDAD-------IGE 280
Query: 943 NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRY-FVINERHGHV 1001
N I + +L S + ++ + N+ + K D E + ++ G +
Sbjct: 281 NAK-----IHFSFSNLVSNIARRL-FHLNATTGLITIKEPLDREETPNHKLLVLASDGGL 334
Query: 1002 IVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTR 1061
+ AR++ + ++ D + +I +R V VND + + N T+
Sbjct: 335 MPARAM-------VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN--------TK 379
Query: 1062 RVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETEDKYIL 1118
L V DAD N +T F +D ++PF + P+ +L LD E+ +Y +
Sbjct: 380 IALITVTDKDAD--HNGRVTCF---TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAI 434
Query: 1119 TVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMM 1178
++A D G D NDN+P F + PE + + M
Sbjct: 435 KLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPENNSPGIQLTKVSAM 491
Query: 1179 IPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL--------GLP 1230
+ N +G F+ D G ++ L + K + L G+P
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLD---CRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 548
Query: 1231 SLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEHYENF 1288
L+S + V++ D D + PVF Y + EN+ + V L+++ ++ +N
Sbjct: 549 PLTSNVTVFVSIIDQND-----NSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ IL+END F ID + G + S DRE +++Y V+
Sbjct: 604 AVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK-------------- 644
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAPFGYQVMQL 1404
AED KV + + DVNDN P F N +P+T P G V Q+
Sbjct: 645 ---AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQV 698
Score = 77.4 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 488 VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE-----DKYLFTIL 541
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + YN + ENLP +V + TD D G+
Sbjct: 542 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 601
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 602 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 647
Score = 76.2 bits (179), Expect = 9e-13
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 21/178 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A+D D+G+ YELI + +F LD + L ++KELD + + +T+
Sbjct: 163 AVDPDVGINGVQNYELIKSQN--IFGLDVIETPEGDKMPQLIVQKELDRE-----EKDTY 215
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V++V+ P +++ A +++ + D NDN P F+ +SI EN P G SV Q+ ATD
Sbjct: 216 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 275
Query: 333 KDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D GEN + + + + F ++ +G +T++ LDRE + ++ V A +
Sbjct: 276 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP--LDREETPNHKLLVLASD 331
Score = 67.7 bits (158), Expect = 3e-10
Identities = 82/341 (24%), Positives = 143/341 (41%), Gaps = 47/341 (13%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTV 134
++I + + IED+NDN P+F T ++++ E + K L A + P + I
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK--YTLPAAVDPDVGI--NG 172
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR-KVLDYDAG 193
+ + K F D TP D ++ + L+ K +++ KV D
Sbjct: 173 VQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE-----LDREEKDTYVMKVKVEDGGFP 227
Query: 194 DKEFQLVIMASG----------KRIHKEILFPE---------PIHAIDQDLGVGATLRYE 234
+ ++ S K E+ PE +HA D D+G A + +
Sbjct: 228 QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFS 287
Query: 235 ---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQAR 291
L+S R+LF L++ G + +++ LD + N + L V AS + L A+A
Sbjct: 288 FSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----LLVLAS--DGGLMPARAM 340
Query: 292 VEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN+P ++ + N ++V EN+P + + TDKD NG T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-F 399
Query: 346 DDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D + F + P S + LD E+ +K+ A +
Sbjct: 400 TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAAD 440
Score = 64.1 bits (149), Expect = 4e-09
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 413 SNQFLLETAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 469
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G + +V A D D G N + Y L D FS+D R+G LTV +
Sbjct: 470 FVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-- 527
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 528 LDREKEDKYLFTILAKD 544
Score = 63.3 bits (147), Expect = 6e-09
Identities = 103/485 (21%), Positives = 185/485 (38%), Gaps = 50/485 (10%)
Query: 940 IPENIPIGTTIIKLN-ALDLDSGLNGQIRYEFNSEVY-IPPSKLSADALEVKRYFVINER 997
+PEN+ IG + LN +L + L ++++ + +P ++ D E+ F R
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEI---FTTGAR 90
Query: 998 HGHVIVARSLPPESEFRLNIS-ALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ +P + + A+ + + +R ++D+ND+ P+F T N ++ E
Sbjct: 91 IDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPE 150
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGELDRE 1111
A D D G N Y + S ++ L V ELDRE
Sbjct: 151 NSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE 210
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
+D Y++ V D G D NDN P F + +E PE +
Sbjct: 211 EKDTYVMKVKVEDGG-FPQRSSTAILQVSVTDTNDNHPVFKETE--IEVSIPENAPVGT- 266
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLP----QRKNQ 1224
SV + A I ENA I + + + +N + + N GLI P + N
Sbjct: 267 ---SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 1225 QNLGLPS----LSSTAILMVTVADVPDEVEMSDKPVFISRYYE-LEIEENVNAPVELVSL 1279
+ L L S + + A+++V V DV D V D ++ + + + EN+ ++ +
Sbjct: 324 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 383
Query: 1280 NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQK 1339
+T+ + R +++ R R V ++ A
Sbjct: 384 TVTDKDADHNGRVTCFTDHEIPFRL------------------RPVFSNQFLLETAAYLD 425
Query: 1340 YSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGY 1399
Y + I +A D + + +++KD NDN+P FT + +IP G
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF--VTVSIPENNSPGI 483
Query: 1400 QVMQL 1404
Q+ ++
Sbjct: 484 QLTKV 488
Score = 58.4 bits (135), Expect = 2e-07
Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 644
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V N S LP+ G V QV+A D D
Sbjct: 645 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDND 704
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 705 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 750
Score = 52.8 bits (121), Expect = 9e-06
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ PSN YE + S GTV+ +V AVD D G N V Y
Sbjct: 655 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 714 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 768
Query: 556 TIEV 559
+ V
Sbjct: 769 NLFV 772
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/206 (24%), Positives = 93/206 (45%), Gaps = 27/206 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSLTI 130
G+ +++ ++V V I D NDN P+F Y+ V E P G I + P G + +
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 605
Query: 131 PL---------TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L T+ + + +FDR+K + + V D G + SS K
Sbjct: 606 TLSILDENDDFTIDSQTGVIRPNISFDREKQES-----YTFYVKAEDGGRVSRSSSAKVT 660
Query: 182 LLLRKVLD------YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
+ + V D + ++LV+ ++ ++F + A+D D G+ A +RY +
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT---VVFQ--VIAVDNDTGMNAEVRYSI 715
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDL 261
+ GN R LF++D G++ L ++ D+
Sbjct: 716 VGGNTRDLFAIDQETGNITLMEKCDV 741
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/114 (29%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS--LTIPLTVPRGLT 139
S T Y++ D + + VT++ + K +F++ P S L +P T P G
Sbjct: 638 SYTFYVK-AEDGGRVSRSSSAKVTINVVDVNDNKP-VFIVPPSNCSYELVLPSTNP-GTV 694
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 695 VFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 745
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
LT A D+D G NA I Y + + P F++D +G + VV L R+
Sbjct: 485 LTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 225 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 265
>AL121869-4|CAI41413.1| 1347|Homo sapiens protocadherin 11 X-linked
protein.
Length = 1347
Score = 138 bits (333), Expect = 2e-31
Identities = 140/517 (27%), Positives = 223/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 211 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 263
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 264 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 324 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + +++ + + ++
Sbjct: 378 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ I T +S++
Sbjct: 436 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG----IQLTKVSAM 491
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ N + D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 550
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y ++ EN + GT +I TD D G N+
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 606
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 607 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701
Score = 113 bits (273), Expect = 3e-24
Identities = 116/473 (24%), Positives = 203/473 (42%), Gaps = 23/473 (4%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+++ V + + D NDN P+F P+ + S+ N+ + + AVDPD+G NG+
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLF-PATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 497 YDLQRTSNLTITSPFKINPNTGTVS--VAESPILEGRHALFVEASDQPANPSERRYSLAV 554
Y+L ++ N+ + P + + + + +V +R S A+
Sbjct: 176 YELIKSQNIFGLDVIE-TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 234
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQN---DVSYDL 610
+ + VT T N P F E + N +GTSV Q+ DA +N S+
Sbjct: 235 LQVSVT-DTNDNH---PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN 290
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L F + +G+IT+ + L R P + +A + + V+V DVN
Sbjct: 291 LVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDGGLMPARAMVLVNVTDVN 349
Query: 671 DE-RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D + ++ +P+ V + +I ++ + G V ++
Sbjct: 350 DNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVI-AEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ + T LD E Y + ++ A+ K ++ + + + I ++DENDN PVF
Sbjct: 410 PVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKDENDNAPVFT 467
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ I EN+ G ++ + A DAD G NA Y L + F +D TG++
Sbjct: 468 QSFVTVSIPENNSPGIQLTK---VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTV 524
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
+ LDREK+ Y +++A+D G L+S + + I D+NDN P F E N
Sbjct: 525 V-KKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Score = 97.9 bits (233), Expect = 2e-19
Identities = 81/246 (32%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G + K++A+D DSG N +I Y
Sbjct: 446 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYL 504
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 505 LGPDA--PPE------------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF YNF V E +G + TD D+G N+ +T I
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 610
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 611 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 667
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 668 DNKPVF 673
Score = 77.8 bits (183), Expect = 3e-13
Identities = 157/658 (23%), Positives = 255/658 (38%), Gaps = 104/658 (15%)
Query: 770 IYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL 829
+ ++ IED NDN P+F I ENS I ++ + A D D G N + Y L
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLP---AAVDPDVGINGVQNYEL 178
Query: 830 FGE----GKEMFDVDENTGVVKFI-GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIM 882
G ++ + E + + I LDRE+K Y + + D G SS A L +
Sbjct: 179 IKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238
Query: 883 IGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPE 942
+ D NDN P F + E I N G ++ ++ A D D I E
Sbjct: 239 VTDTNDNHPVFKETE------IEVSIPENAPVGTSVTQL-----HATDAD-------IGE 280
Query: 943 NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRY-FVINERHGHV 1001
N I + +L S + ++ + N+ + K D E + ++ G +
Sbjct: 281 NAK-----IHFSFSNLVSNIARRL-FHLNATTGLITIKEPLDREETPNHKLLVLASDGGL 334
Query: 1002 IVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTR 1061
+ AR++ + ++ D + +I +R V VND + + N T+
Sbjct: 335 MPARAM-------VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN--------TK 379
Query: 1062 RVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETEDKYIL 1118
L V DAD N +T F +D ++PF + P+ +L LD E+ +Y +
Sbjct: 380 IALITVTDKDAD--HNGRVTCF---TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAI 434
Query: 1119 TVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMM 1178
++A D G D NDN+P F + PE + + M
Sbjct: 435 KLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPENNSPGIQLTKVSAM 491
Query: 1179 IPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL--------GLP 1230
+ N +G F+ D G ++ L + K + L G+P
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLD---CRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 548
Query: 1231 SLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEHYENF 1288
L+S + V++ D D + PVF Y + EN+ + V L+++ ++ +N
Sbjct: 549 PLTSNVTVFVSIIDQND-----NSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ IL+END F ID + G + S DRE +++Y V+
Sbjct: 604 AVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK-------------- 644
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAPFGYQVMQL 1404
AED KV + + DVNDN P F N +P+T P G V Q+
Sbjct: 645 ---AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQV 698
Score = 77.4 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 488 VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE-----DKYLFTIL 541
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + YN + ENLP +V + TD D G+
Sbjct: 542 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 601
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 602 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 647
Score = 76.2 bits (179), Expect = 9e-13
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 21/178 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A+D D+G+ YELI + +F LD + L ++KELD + + +T+
Sbjct: 163 AVDPDVGINGVQNYELIKSQN--IFGLDVIETPEGDKMPQLIVQKELDRE-----EKDTY 215
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V++V+ P +++ A +++ + D NDN P F+ +SI EN P G SV Q+ ATD
Sbjct: 216 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 275
Query: 333 KDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D GEN + + + + F ++ +G +T++ LDRE + ++ V A +
Sbjct: 276 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP--LDREETPNHKLLVLASD 331
Score = 67.7 bits (158), Expect = 3e-10
Identities = 82/341 (24%), Positives = 143/341 (41%), Gaps = 47/341 (13%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTV 134
++I + + IED+NDN P+F T ++++ E + K L A + P + I
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK--YTLPAAVDPDVGI--NG 172
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR-KVLDYDAG 193
+ + K F D TP D ++ + L+ K +++ KV D
Sbjct: 173 VQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE-----LDREEKDTYVMKVKVEDGGFP 227
Query: 194 DKEFQLVIMASG----------KRIHKEILFPE---------PIHAIDQDLGVGATLRYE 234
+ ++ S K E+ PE +HA D D+G A + +
Sbjct: 228 QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFS 287
Query: 235 ---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQAR 291
L+S R+LF L++ G + +++ LD + N + L V AS + L A+A
Sbjct: 288 FSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----LLVLAS--DGGLMPARAM 340
Query: 292 VEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN+P ++ + N ++V EN+P + + TDKD NG T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-F 399
Query: 346 DDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D + F + P S + LD E+ +K+ A +
Sbjct: 400 TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAAD 440
Score = 64.1 bits (149), Expect = 4e-09
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 413 SNQFLLETAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 469
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G + +V A D D G N + Y L D FS+D R+G LTV +
Sbjct: 470 FVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-- 527
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 528 LDREKEDKYLFTILAKD 544
Score = 63.3 bits (147), Expect = 6e-09
Identities = 103/485 (21%), Positives = 185/485 (38%), Gaps = 50/485 (10%)
Query: 940 IPENIPIGTTIIKLN-ALDLDSGLNGQIRYEFNSEVY-IPPSKLSADALEVKRYFVINER 997
+PEN+ IG + LN +L + L ++++ + +P ++ D E+ F R
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEI---FTTGAR 90
Query: 998 HGHVIVARSLPPESEFRLNIS-ALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ +P + + A+ + + +R ++D+ND+ P+F T N ++ E
Sbjct: 91 IDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPE 150
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGELDRE 1111
A D D G N Y + S ++ L V ELDRE
Sbjct: 151 NSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE 210
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
+D Y++ V D G D NDN P F + +E PE +
Sbjct: 211 EKDTYVMKVKVEDGG-FPQRSSTAILQVSVTDTNDNHPVFKETE--IEVSIPENAPVGT- 266
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLP----QRKNQ 1224
SV + A I ENA I + + + +N + + N GLI P + N
Sbjct: 267 ---SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 1225 QNLGLPS----LSSTAILMVTVADVPDEVEMSDKPVFISRYYE-LEIEENVNAPVELVSL 1279
+ L L S + + A+++V V DV D V D ++ + + + EN+ ++ +
Sbjct: 324 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 383
Query: 1280 NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQK 1339
+T+ + R +++ R R V ++ A
Sbjct: 384 TVTDKDADHNGRVTCFTDHEIPFRL------------------RPVFSNQFLLETAAYLD 425
Query: 1340 YSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGY 1399
Y + I +A D + + +++KD NDN+P FT + +IP G
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF--VTVSIPENNSPGI 483
Query: 1400 QVMQL 1404
Q+ ++
Sbjct: 484 QLTKV 488
Score = 58.4 bits (135), Expect = 2e-07
Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 644
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V N S LP+ G V QV+A D D
Sbjct: 645 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDND 704
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 705 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 750
Score = 52.8 bits (121), Expect = 9e-06
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ PSN YE + S GTV+ +V AVD D G N V Y
Sbjct: 655 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 714 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 768
Query: 556 TIEV 559
+ V
Sbjct: 769 NLFV 772
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/206 (24%), Positives = 93/206 (45%), Gaps = 27/206 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSLTI 130
G+ +++ ++V V I D NDN P+F Y+ V E P G I + P G + +
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 605
Query: 131 PL---------TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L T+ + + +FDR+K + + V D G + SS K
Sbjct: 606 TLSILDENDDFTIDSQTGVIRPNISFDREKQES-----YTFYVKAEDGGRVSRSSSAKVT 660
Query: 182 LLLRKVLD------YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
+ + V D + ++LV+ ++ ++F + A+D D G+ A +RY +
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT---VVFQ--VIAVDNDTGMNAEVRYSI 715
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDL 261
+ GN R LF++D G++ L ++ D+
Sbjct: 716 VGGNTRDLFAIDQETGNITLMEKCDV 741
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/114 (29%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS--LTIPLTVPRGLT 139
S T Y++ D + + VT++ + K +F++ P S L +P T P G
Sbjct: 638 SYTFYVK-AEDGGRVSRSSSAKVTINVVDVNDNKP-VFIVPPSNCSYELVLPSTNP-GTV 694
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 695 VFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 745
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
LT A D+D G NA I Y + + P F++D +G + VV L R+
Sbjct: 485 LTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 225 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 265
>AL121869-3|CAI41412.1| 1310|Homo sapiens protocadherin 11 X-linked
protein.
Length = 1310
Score = 138 bits (333), Expect = 2e-31
Identities = 140/517 (27%), Positives = 223/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 211 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 263
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 264 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 324 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + +++ + + ++
Sbjct: 378 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ I T +S++
Sbjct: 436 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG----IQLTKVSAM 491
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ N + D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 550
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y ++ EN + GT +I TD D G N+
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 606
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 607 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701
Score = 113 bits (273), Expect = 3e-24
Identities = 116/473 (24%), Positives = 203/473 (42%), Gaps = 23/473 (4%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+++ V + + D NDN P+F P+ + S+ N+ + + AVDPD+G NG+
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLF-PATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 497 YDLQRTSNLTITSPFKINPNTGTVS--VAESPILEGRHALFVEASDQPANPSERRYSLAV 554
Y+L ++ N+ + P + + + + +V +R S A+
Sbjct: 176 YELIKSQNIFGLDVIE-TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 234
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQN---DVSYDL 610
+ + VT T N P F E + N +GTSV Q+ DA +N S+
Sbjct: 235 LQVSVT-DTNDNH---PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN 290
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L F + +G+IT+ + L R P + +A + + V+V DVN
Sbjct: 291 LVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDGGLMPARAMVLVNVTDVN 349
Query: 671 DE-RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D + ++ +P+ V + +I ++ + G V ++
Sbjct: 350 DNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVI-AEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ + T LD E Y + ++ A+ K ++ + + + I ++DENDN PVF
Sbjct: 410 PVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKDENDNAPVFT 467
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ I EN+ G ++ + A DAD G NA Y L + F +D TG++
Sbjct: 468 QSFVTVSIPENNSPGIQLTK---VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTV 524
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
+ LDREK+ Y +++A+D G L+S + + I D+NDN P F E N
Sbjct: 525 V-KKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Score = 97.9 bits (233), Expect = 2e-19
Identities = 81/246 (32%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G + K++A+D DSG N +I Y
Sbjct: 446 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYL 504
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 505 LGPDA--PPE------------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF YNF V E +G + TD D+G N+ +T I
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 610
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 611 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 667
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 668 DNKPVF 673
Score = 77.8 bits (183), Expect = 3e-13
Identities = 157/658 (23%), Positives = 255/658 (38%), Gaps = 104/658 (15%)
Query: 770 IYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL 829
+ ++ IED NDN P+F I ENS I ++ + A D D G N + Y L
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLP---AAVDPDVGINGVQNYEL 178
Query: 830 FGE----GKEMFDVDENTGVVKFI-GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIM 882
G ++ + E + + I LDRE+K Y + + D G SS A L +
Sbjct: 179 IKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238
Query: 883 IGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPE 942
+ D NDN P F + E I N G ++ ++ A D D I E
Sbjct: 239 VTDTNDNHPVFKETE------IEVSIPENAPVGTSVTQL-----HATDAD-------IGE 280
Query: 943 NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRY-FVINERHGHV 1001
N I + +L S + ++ + N+ + K D E + ++ G +
Sbjct: 281 NAK-----IHFSFSNLVSNIARRL-FHLNATTGLITIKEPLDREETPNHKLLVLASDGGL 334
Query: 1002 IVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTR 1061
+ AR++ + ++ D + +I +R V VND + + N T+
Sbjct: 335 MPARAM-------VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN--------TK 379
Query: 1062 RVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETEDKYIL 1118
L V DAD N +T F +D ++PF + P+ +L LD E+ +Y +
Sbjct: 380 IALITVTDKDAD--HNGRVTCF---TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAI 434
Query: 1119 TVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMM 1178
++A D G D NDN+P F + PE + + M
Sbjct: 435 KLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPENNSPGIQLTKVSAM 491
Query: 1179 IPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL--------GLP 1230
+ N +G F+ D G ++ L + K + L G+P
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLD---CRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 548
Query: 1231 SLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEHYENF 1288
L+S + V++ D D + PVF Y + EN+ + V L+++ ++ +N
Sbjct: 549 PLTSNVTVFVSIIDQND-----NSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ IL+END F ID + G + S DRE +++Y V+
Sbjct: 604 AVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK-------------- 644
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAPFGYQVMQL 1404
AED KV + + DVNDN P F N +P+T P G V Q+
Sbjct: 645 ---AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQV 698
Score = 77.4 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 488 VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE-----DKYLFTIL 541
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + YN + ENLP +V + TD D G+
Sbjct: 542 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 601
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 602 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 647
Score = 76.2 bits (179), Expect = 9e-13
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 21/178 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A+D D+G+ YELI + +F LD + L ++KELD + + +T+
Sbjct: 163 AVDPDVGINGVQNYELIKSQN--IFGLDVIETPEGDKMPQLIVQKELDRE-----EKDTY 215
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V++V+ P +++ A +++ + D NDN P F+ +SI EN P G SV Q+ ATD
Sbjct: 216 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 275
Query: 333 KDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D GEN + + + + F ++ +G +T++ LDRE + ++ V A +
Sbjct: 276 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP--LDREETPNHKLLVLASD 331
Score = 67.7 bits (158), Expect = 3e-10
Identities = 82/341 (24%), Positives = 143/341 (41%), Gaps = 47/341 (13%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTV 134
++I + + IED+NDN P+F T ++++ E + K L A + P + I
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK--YTLPAAVDPDVGI--NG 172
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR-KVLDYDAG 193
+ + K F D TP D ++ + L+ K +++ KV D
Sbjct: 173 VQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE-----LDREEKDTYVMKVKVEDGGFP 227
Query: 194 DKEFQLVIMASG----------KRIHKEILFPE---------PIHAIDQDLGVGATLRYE 234
+ ++ S K E+ PE +HA D D+G A + +
Sbjct: 228 QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFS 287
Query: 235 ---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQAR 291
L+S R+LF L++ G + +++ LD + N + L V AS + L A+A
Sbjct: 288 FSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----LLVLAS--DGGLMPARAM 340
Query: 292 VEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN+P ++ + N ++V EN+P + + TDKD NG T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-F 399
Query: 346 DDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D + F + P S + LD E+ +K+ A +
Sbjct: 400 TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAAD 440
Score = 64.1 bits (149), Expect = 4e-09
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 413 SNQFLLETAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 469
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G + +V A D D G N + Y L D FS+D R+G LTV +
Sbjct: 470 FVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-- 527
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 528 LDREKEDKYLFTILAKD 544
Score = 63.3 bits (147), Expect = 6e-09
Identities = 103/485 (21%), Positives = 185/485 (38%), Gaps = 50/485 (10%)
Query: 940 IPENIPIGTTIIKLN-ALDLDSGLNGQIRYEFNSEVY-IPPSKLSADALEVKRYFVINER 997
+PEN+ IG + LN +L + L ++++ + +P ++ D E+ F R
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEI---FTTGAR 90
Query: 998 HGHVIVARSLPPESEFRLNIS-ALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ +P + + A+ + + +R ++D+ND+ P+F T N ++ E
Sbjct: 91 IDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPE 150
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGELDRE 1111
A D D G N Y + S ++ L V ELDRE
Sbjct: 151 NSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE 210
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
+D Y++ V D G D NDN P F + +E PE +
Sbjct: 211 EKDTYVMKVKVEDGG-FPQRSSTAILQVSVTDTNDNHPVFKETE--IEVSIPENAPVGT- 266
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLP----QRKNQ 1224
SV + A I ENA I + + + +N + + N GLI P + N
Sbjct: 267 ---SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 1225 QNLGLPS----LSSTAILMVTVADVPDEVEMSDKPVFISRYYE-LEIEENVNAPVELVSL 1279
+ L L S + + A+++V V DV D V D ++ + + + EN+ ++ +
Sbjct: 324 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 383
Query: 1280 NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQK 1339
+T+ + R +++ R R V ++ A
Sbjct: 384 TVTDKDADHNGRVTCFTDHEIPFRL------------------RPVFSNQFLLETAAYLD 425
Query: 1340 YSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGY 1399
Y + I +A D + + +++KD NDN+P FT + +IP G
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF--VTVSIPENNSPGI 483
Query: 1400 QVMQL 1404
Q+ ++
Sbjct: 484 QLTKV 488
Score = 58.4 bits (135), Expect = 2e-07
Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 644
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V N S LP+ G V QV+A D D
Sbjct: 645 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDND 704
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 705 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 750
Score = 52.8 bits (121), Expect = 9e-06
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ PSN YE + S GTV+ +V AVD D G N V Y
Sbjct: 655 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 714 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 768
Query: 556 TIEV 559
+ V
Sbjct: 769 NLFV 772
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/206 (24%), Positives = 93/206 (45%), Gaps = 27/206 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSLTI 130
G+ +++ ++V V I D NDN P+F Y+ V E P G I + P G + +
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 605
Query: 131 PL---------TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L T+ + + +FDR+K + + V D G + SS K
Sbjct: 606 TLSILDENDDFTIDSQTGVIRPNISFDREKQES-----YTFYVKAEDGGRVSRSSSAKVT 660
Query: 182 LLLRKVLD------YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
+ + V D + ++LV+ ++ ++F + A+D D G+ A +RY +
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT---VVFQ--VIAVDNDTGMNAEVRYSI 715
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDL 261
+ GN R LF++D G++ L ++ D+
Sbjct: 716 VGGNTRDLFAIDQETGNITLMEKCDV 741
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/114 (29%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS--LTIPLTVPRGLT 139
S T Y++ D + + VT++ + K +F++ P S L +P T P G
Sbjct: 638 SYTFYVK-AEDGGRVSRSSSAKVTINVVDVNDNKP-VFIVPPSNCSYELVLPSTNP-GTV 694
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 695 VFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 745
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
LT A D+D G NA I Y + + P F++D +G + VV L R+
Sbjct: 485 LTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 225 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 265
>AJ564963-1|CAD92434.1| 787|Homo sapiens protocadherin protein.
Length = 787
Score = 138 bits (333), Expect = 2e-31
Identities = 138/517 (26%), Positives = 224/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 31 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 83
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 84 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 143
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 144 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 197
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + ++++ + + ++
Sbjct: 198 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLENAAYLDYESTKEYAIK 255
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ Q+ + +
Sbjct: 256 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI--QLMKVSATDA 313
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ +L+ D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 314 DSGPNAEINYLLG--PDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 370
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y+ ++ EN + GT +I TD D G N+
Sbjct: 371 TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 426
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 427 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 484
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 485 DVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAV 521
Score = 116 bits (278), Expect = 9e-25
Identities = 124/424 (29%), Positives = 193/424 (45%), Gaps = 50/424 (11%)
Query: 931 VDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKR 990
V+ + ++ ENIP+ T I + D D+ NG++ + E+ P +L
Sbjct: 181 VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI---PFRLRP---VFSN 234
Query: 991 YFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK 1046
F++ A L ES E+ + + A D G LN + + + VKD ND+ PVF
Sbjct: 235 QFLLEN-------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFT 287
Query: 1047 KTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
+++ ++ E L KV ATDAD G NA + Y + P D F + TG+L+V
Sbjct: 288 QSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGP-DAPPEFSLDRRTGMLTVVK 346
Query: 1107 ELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEAD 1166
+LDRE EDKY+ T++A+DNG D NDNSP F E+K +
Sbjct: 347 KLDREKEDKYLFTILAKDNG-VPPLTSNVTVFVSIIDQNDNSPVF----THNEYKFYVPE 401
Query: 1167 ELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLP-QRKNQQ 1225
L H +V +I V +N+ + T++ + ND I + G+I ++ R+ Q+
Sbjct: 402 NLPRHG--TVGLITVTDPDYGDNSAV--TLSILDENDDFTIDSQTGVIRPNISFDREKQE 457
Query: 1226 NL---------GLPSLSSTAILMVTVADVPDEVEMSDKPVFI----SRYYELEI-EENVN 1271
+ G S SS+A + + V DV D +KPVFI + YEL + N
Sbjct: 458 SYTFYVKAEDGGRVSRSSSAKVTINVVDVND-----NKPVFIVPPYNYSYELVLPSTNPG 512
Query: 1272 APVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEV 1331
V V + N ++RY I+ N D+ F ID G + L+ D + V
Sbjct: 513 TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRV 569
Query: 1332 IVRA 1335
+V+A
Sbjct: 570 LVKA 573
Score = 97.1 bits (231), Expect = 4e-19
Identities = 80/246 (32%), Positives = 107/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G ++K++A D DSG N +I Y
Sbjct: 266 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYL 324
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 325 LGPDA--PPE------------FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 370
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF Y F V E +G + TD D+G N+ +T I
Sbjct: 371 TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 430
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 431 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 487
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 488 DNKPVF 493
Score = 89.4 bits (212), Expect = 9e-17
Identities = 128/492 (26%), Positives = 201/492 (40%), Gaps = 78/492 (15%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P+GT++ +L+A D D G N +I + F++ V S ++ +R F +N G
Sbjct: 78 IPENAPVGTSVTQLHATDADIGENAKIHFSFSNLV----SNIA------RRLFHLNATTG 127
Query: 1000 HVIVARSLPPES--EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTW----YNFN 1053
+ + L E +L + A DGG + V V V DVND+ P + N
Sbjct: 128 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 187
Query: 1054 V--EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGEL 1108
V E + + TD D N +T F +D ++PF + P+ +L L
Sbjct: 188 VVLSENIPLNTKIALITVTDKDADHNGRVTCF---TDHEIPFRLRPVFSNQFLLENAAYL 244
Query: 1109 DRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADEL 1168
D E+ +Y + ++A D G D NDN+P F + PE
Sbjct: 245 DYESTKEYAIKLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPE---- 297
Query: 1169 SNHNFESVMMIPVYKATIEENAPI----GTTVAKVFANDTDFIGNGNGLILYSLPQRKNQ 1224
+N +M + A NA I G F+ D G ++ L + K
Sbjct: 298 NNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDR---RTGMLTVVKKLDREKED 354
Query: 1225 QNL--------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPV 1274
+ L G+P L+S + V++ D D + PVF Y+ + EN+ + V
Sbjct: 355 KYLFTILAKDNGVPPLTSNVTVFVSIIDQND-----NSPVFTHNEYKFYVPENLPRHGTV 409
Query: 1275 ELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVR 1334
L+++ ++ +N + IL+END F ID + G + S DRE +++Y V+
Sbjct: 410 GLITVTDPDYGDNSAVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK 464
Query: 1335 AERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIP 1392
AED KV + + DVNDN P F N +P
Sbjct: 465 -----------------AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP 507
Query: 1393 TTAPFGYQVMQL 1404
+T P G V Q+
Sbjct: 508 STNP-GTVVFQV 518
Score = 83.0 bits (196), Expect = 7e-15
Identities = 53/161 (32%), Positives = 85/161 (52%), Gaps = 9/161 (5%)
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
+ QK LDRE++D Y M V E + G + + + + D NDN PVF+ E I
Sbjct: 21 LIVQKELDREEKDTYVMKVKVE-DGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIP 79
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNA----LFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
EN+ +GT + + ATDAD G NA F + + +F ++ TG++ I + L
Sbjct: 80 ENAPVGTSVTQ---LHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLIT-IKEPL 135
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFN 894
DRE+ +KL ++A D G + + A +++ + D NDN P +
Sbjct: 136 DREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID 176
Score = 78.6 bits (185), Expect = 2e-13
Identities = 101/406 (24%), Positives = 173/406 (42%), Gaps = 58/406 (14%)
Query: 1001 VIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+IV + L E + + + + DGG + ++V V D ND+ PVFK+T ++ E
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPE 80
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP---FEISPLTGVLSVNGELDRETE 1113
+ ++ ATDAD G+NA + + +++ F ++ TG++++ LDRE
Sbjct: 81 NAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREET 140
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE-LSNHN 1172
+ L V+A D G DVNDN P ++ +P D + + N
Sbjct: 141 PNHKLLVLASDGG---LMPARAMVLVNVTDVNDNVPSI----DIRYIVNPVNDTVVLSEN 193
Query: 1173 F---ESVMMIPVYKATIEENA--------PIGTTVAKVFANDTDFIGNGNGLILYSLPQ- 1220
+ +I V + N I + VF+N + N L S +
Sbjct: 194 IPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQF-LLENAAYLDYESTKEY 252
Query: 1221 --RKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVS 1278
+ + G P L+ +A+L + V D E + PVF + + I EN + ++L+
Sbjct: 253 AIKLLAADAGKPPLNQSAMLFIKVKD-----ENDNAPVFTQSFVTVSIPENNSPGIQLMK 307
Query: 1279 LNLT--EHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAE 1336
++ T + N ++ Y + D F +D R G L +V+ DRE +D Y + A+
Sbjct: 308 VSATDADSGPNAEINYLL----GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK 363
Query: 1337 RQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTN 1382
+ + P+ +V V V I D NDNSP FT+
Sbjct: 364 --------DNGVPPLTS---------NVTVFVSIIDQNDNSPVFTH 392
Score = 74.1 bits (174), Expect = 3e-12
Identities = 51/168 (30%), Positives = 78/168 (46%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 308 VSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKE-----DKYLFTIL 361
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + Y + ENLP +V + TD D G+
Sbjct: 362 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGD 421
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 422 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 467
Score = 70.1 bits (164), Expect = 6e-11
Identities = 46/137 (33%), Positives = 65/137 (47%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 233 SNQFLLENAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 289
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G +++V ATD D G N E Y L D FS+D R+G LTV +
Sbjct: 290 FVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKK-- 347
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 348 LDREKEDKYLFTILAKD 364
Score = 64.9 bits (151), Expect = 2e-09
Identities = 41/138 (29%), Positives = 74/138 (53%), Gaps = 12/138 (8%)
Query: 253 LFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN 312
L ++KELD + + +T+V++V+ P +++ A +++ + D NDN P F+
Sbjct: 21 LIVQKELDRE-----EKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 75
Query: 313 ISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQT 367
+SI EN P G SV Q+ ATD D GEN + + + + F ++ +G +T++
Sbjct: 76 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP- 134
Query: 368 VLDREAHSSLRMKVYAKE 385
LDRE + ++ V A +
Sbjct: 135 -LDREETPNHKLLVLASD 151
Score = 62.1 bits (144), Expect = 1e-08
Identities = 51/178 (28%), Positives = 86/178 (48%), Gaps = 18/178 (10%)
Query: 218 IHAIDQDLGVGATLRYE---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
+HA D D+G A + + L+S R+LF L++ G + +++ LD + N + L
Sbjct: 91 LHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----L 145
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQV 328
V AS + L A+A V + + D+NDN+P ++ + N ++V EN+P + +
Sbjct: 146 LVLAS--DGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 203
Query: 329 MATDKDQGENGEFTYQLDDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TDKD NG T D + F + P S + N LD E+ +K+ A +
Sbjct: 204 TVTDKDADHNGRVTC-FTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAAD 260
Score = 62.1 bits (144), Expect = 1e-08
Identities = 49/166 (29%), Positives = 78/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 412 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 464
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V YN S LP+ G V QV+A D D
Sbjct: 465 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDND 524
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 525 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 570
Score = 50.4 bits (115), Expect = 5e-05
Identities = 39/124 (31%), Positives = 62/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ P N YE + S GTV+ +V AVD D G N V Y
Sbjct: 475 SSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 533
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 534 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 588
Query: 556 TIEV 559
+ V
Sbjct: 589 NLFV 592
Score = 48.0 bits (109), Expect = 3e-04
Identities = 47/166 (28%), Positives = 71/166 (42%), Gaps = 12/166 (7%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEH--Y 1285
G P SSTAIL V+V D D + PVF E+ I EN + L+ T+
Sbjct: 45 GFPQRSSTAILQVSVTDTND-----NHPVFKETEIEVSIPENAPVGTSVTQLHATDADIG 99
Query: 1286 ENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
EN K+ + N RR F ++ G + + DRE ++++V A
Sbjct: 100 ENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARA 159
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAI 1391
++ V DV + + D++ +V VND + N PL T I
Sbjct: 160 MVLVNVT-DVNDNVPSIDIRYIV--NPVNDT--VVLSENIPLNTKI 200
Score = 40.7 bits (91), Expect = 0.039
Identities = 36/116 (31%), Positives = 53/116 (45%), Gaps = 24/116 (20%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRG 137
S+ VT+ + DVNDN P+F+ PY+ + + L +P T P G
Sbjct: 474 SSSAKVTINVVDVNDNKPVFIVPPYNYSYE--------------------LVLPSTNP-G 512
Query: 138 LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 513 TVVFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 565
Score = 35.9 bits (79), Expect = 1.1
Identities = 18/47 (38%), Positives = 27/47 (57%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
L ATD+D G NA+I Y + + P F++D +G + VV L R+
Sbjct: 305 LMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 351
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 45 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 85
>AJ564962-1|CAD92433.1| 762|Homo sapiens protocadherin protein.
Length = 762
Score = 138 bits (333), Expect = 2e-31
Identities = 138/517 (26%), Positives = 224/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 31 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 83
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 84 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 143
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 144 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 197
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + ++++ + + ++
Sbjct: 198 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLENAAYLDYESTKEYAIK 255
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ Q+ + +
Sbjct: 256 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI--QLMKVSATDA 313
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ +L+ D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 314 DSGPNAEINYLLG--PDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 370
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y+ ++ EN + GT +I TD D G N+
Sbjct: 371 TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 426
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 427 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 484
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 485 DVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAV 521
Score = 116 bits (278), Expect = 9e-25
Identities = 124/424 (29%), Positives = 193/424 (45%), Gaps = 50/424 (11%)
Query: 931 VDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKR 990
V+ + ++ ENIP+ T I + D D+ NG++ + E+ P +L
Sbjct: 181 VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI---PFRLRP---VFSN 234
Query: 991 YFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK 1046
F++ A L ES E+ + + A D G LN + + + VKD ND+ PVF
Sbjct: 235 QFLLEN-------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFT 287
Query: 1047 KTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
+++ ++ E L KV ATDAD G NA + Y + P D F + TG+L+V
Sbjct: 288 QSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGP-DAPPEFSLDRRTGMLTVVK 346
Query: 1107 ELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEAD 1166
+LDRE EDKY+ T++A+DNG D NDNSP F E+K +
Sbjct: 347 KLDREKEDKYLFTILAKDNG-VPPLTSNVTVFVSIIDQNDNSPVF----THNEYKFYVPE 401
Query: 1167 ELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLP-QRKNQQ 1225
L H +V +I V +N+ + T++ + ND I + G+I ++ R+ Q+
Sbjct: 402 NLPRHG--TVGLITVTDPDYGDNSAV--TLSILDENDDFTIDSQTGVIRPNISFDREKQE 457
Query: 1226 NL---------GLPSLSSTAILMVTVADVPDEVEMSDKPVFI----SRYYELEI-EENVN 1271
+ G S SS+A + + V DV D +KPVFI + YEL + N
Sbjct: 458 SYTFYVKAEDGGRVSRSSSAKVTINVVDVND-----NKPVFIVPPYNYSYELVLPSTNPG 512
Query: 1272 APVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEV 1331
V V + N ++RY I+ N D+ F ID G + L+ D + V
Sbjct: 513 TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRV 569
Query: 1332 IVRA 1335
+V+A
Sbjct: 570 LVKA 573
Score = 97.1 bits (231), Expect = 4e-19
Identities = 80/246 (32%), Positives = 107/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G ++K++A D DSG N +I Y
Sbjct: 266 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYL 324
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 325 LGPDA--PPE------------FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 370
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF Y F V E +G + TD D+G N+ +T I
Sbjct: 371 TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 430
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 431 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 487
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 488 DNKPVF 493
Score = 89.4 bits (212), Expect = 9e-17
Identities = 128/492 (26%), Positives = 201/492 (40%), Gaps = 78/492 (15%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P+GT++ +L+A D D G N +I + F++ V S ++ +R F +N G
Sbjct: 78 IPENAPVGTSVTQLHATDADIGENAKIHFSFSNLV----SNIA------RRLFHLNATTG 127
Query: 1000 HVIVARSLPPES--EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTW----YNFN 1053
+ + L E +L + A DGG + V V V DVND+ P + N
Sbjct: 128 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 187
Query: 1054 V--EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGEL 1108
V E + + TD D N +T F +D ++PF + P+ +L L
Sbjct: 188 VVLSENIPLNTKIALITVTDKDADHNGRVTCF---TDHEIPFRLRPVFSNQFLLENAAYL 244
Query: 1109 DRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADEL 1168
D E+ +Y + ++A D G D NDN+P F + PE
Sbjct: 245 DYESTKEYAIKLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPE---- 297
Query: 1169 SNHNFESVMMIPVYKATIEENAPI----GTTVAKVFANDTDFIGNGNGLILYSLPQRKNQ 1224
+N +M + A NA I G F+ D G ++ L + K
Sbjct: 298 NNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDR---RTGMLTVVKKLDREKED 354
Query: 1225 QNL--------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPV 1274
+ L G+P L+S + V++ D D + PVF Y+ + EN+ + V
Sbjct: 355 KYLFTILAKDNGVPPLTSNVTVFVSIIDQND-----NSPVFTHNEYKFYVPENLPRHGTV 409
Query: 1275 ELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVR 1334
L+++ ++ +N + IL+END F ID + G + S DRE +++Y V+
Sbjct: 410 GLITVTDPDYGDNSAVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK 464
Query: 1335 AERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIP 1392
AED KV + + DVNDN P F N +P
Sbjct: 465 -----------------AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP 507
Query: 1393 TTAPFGYQVMQL 1404
+T P G V Q+
Sbjct: 508 STNP-GTVVFQV 518
Score = 83.0 bits (196), Expect = 7e-15
Identities = 53/161 (32%), Positives = 85/161 (52%), Gaps = 9/161 (5%)
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
+ QK LDRE++D Y M V E + G + + + + D NDN PVF+ E I
Sbjct: 21 LIVQKELDREEKDTYVMKVKVE-DGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIP 79
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNA----LFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
EN+ +GT + + ATDAD G NA F + + +F ++ TG++ I + L
Sbjct: 80 ENAPVGTSVTQ---LHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLIT-IKEPL 135
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFN 894
DRE+ +KL ++A D G + + A +++ + D NDN P +
Sbjct: 136 DREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID 176
Score = 78.6 bits (185), Expect = 2e-13
Identities = 101/406 (24%), Positives = 173/406 (42%), Gaps = 58/406 (14%)
Query: 1001 VIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+IV + L E + + + + DGG + ++V V D ND+ PVFK+T ++ E
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPE 80
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP---FEISPLTGVLSVNGELDRETE 1113
+ ++ ATDAD G+NA + + +++ F ++ TG++++ LDRE
Sbjct: 81 NAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREET 140
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE-LSNHN 1172
+ L V+A D G DVNDN P ++ +P D + + N
Sbjct: 141 PNHKLLVLASDGG---LMPARAMVLVNVTDVNDNVPSI----DIRYIVNPVNDTVVLSEN 193
Query: 1173 F---ESVMMIPVYKATIEENA--------PIGTTVAKVFANDTDFIGNGNGLILYSLPQ- 1220
+ +I V + N I + VF+N + N L S +
Sbjct: 194 IPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQF-LLENAAYLDYESTKEY 252
Query: 1221 --RKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVS 1278
+ + G P L+ +A+L + V D E + PVF + + I EN + ++L+
Sbjct: 253 AIKLLAADAGKPPLNQSAMLFIKVKD-----ENDNAPVFTQSFVTVSIPENNSPGIQLMK 307
Query: 1279 LNLT--EHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAE 1336
++ T + N ++ Y + D F +D R G L +V+ DRE +D Y + A+
Sbjct: 308 VSATDADSGPNAEINYLL----GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK 363
Query: 1337 RQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTN 1382
+ + P+ +V V V I D NDNSP FT+
Sbjct: 364 --------DNGVPPLTS---------NVTVFVSIIDQNDNSPVFTH 392
Score = 74.1 bits (174), Expect = 3e-12
Identities = 51/168 (30%), Positives = 78/168 (46%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 308 VSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKE-----DKYLFTIL 361
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + Y + ENLP +V + TD D G+
Sbjct: 362 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGD 421
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 422 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 467
Score = 70.1 bits (164), Expect = 6e-11
Identities = 46/137 (33%), Positives = 65/137 (47%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 233 SNQFLLENAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 289
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G +++V ATD D G N E Y L D FS+D R+G LTV +
Sbjct: 290 FVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKK-- 347
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 348 LDREKEDKYLFTILAKD 364
Score = 64.9 bits (151), Expect = 2e-09
Identities = 41/138 (29%), Positives = 74/138 (53%), Gaps = 12/138 (8%)
Query: 253 LFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN 312
L ++KELD + + +T+V++V+ P +++ A +++ + D NDN P F+
Sbjct: 21 LIVQKELDRE-----EKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 75
Query: 313 ISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQT 367
+SI EN P G SV Q+ ATD D GEN + + + + F ++ +G +T++
Sbjct: 76 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP- 134
Query: 368 VLDREAHSSLRMKVYAKE 385
LDRE + ++ V A +
Sbjct: 135 -LDREETPNHKLLVLASD 151
Score = 62.1 bits (144), Expect = 1e-08
Identities = 51/178 (28%), Positives = 86/178 (48%), Gaps = 18/178 (10%)
Query: 218 IHAIDQDLGVGATLRYE---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
+HA D D+G A + + L+S R+LF L++ G + +++ LD + N + L
Sbjct: 91 LHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----L 145
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQV 328
V AS + L A+A V + + D+NDN+P ++ + N ++V EN+P + +
Sbjct: 146 LVLAS--DGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 203
Query: 329 MATDKDQGENGEFTYQLDDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TDKD NG T D + F + P S + N LD E+ +K+ A +
Sbjct: 204 TVTDKDADHNGRVTC-FTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAAD 260
Score = 62.1 bits (144), Expect = 1e-08
Identities = 49/166 (29%), Positives = 78/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 412 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 464
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V YN S LP+ G V QV+A D D
Sbjct: 465 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDND 524
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 525 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 570
Score = 50.4 bits (115), Expect = 5e-05
Identities = 39/124 (31%), Positives = 62/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ P N YE + S GTV+ +V AVD D G N V Y
Sbjct: 475 SSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 533
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 534 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 588
Query: 556 TIEV 559
+ V
Sbjct: 589 NLFV 592
Score = 48.0 bits (109), Expect = 3e-04
Identities = 47/166 (28%), Positives = 71/166 (42%), Gaps = 12/166 (7%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEH--Y 1285
G P SSTAIL V+V D D + PVF E+ I EN + L+ T+
Sbjct: 45 GFPQRSSTAILQVSVTDTND-----NHPVFKETEIEVSIPENAPVGTSVTQLHATDADIG 99
Query: 1286 ENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
EN K+ + N RR F ++ G + + DRE ++++V A
Sbjct: 100 ENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARA 159
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAI 1391
++ V DV + + D++ +V VND + N PL T I
Sbjct: 160 MVLVNVT-DVNDNVPSIDIRYIV--NPVNDT--VVLSENIPLNTKI 200
Score = 40.7 bits (91), Expect = 0.039
Identities = 36/116 (31%), Positives = 53/116 (45%), Gaps = 24/116 (20%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRG 137
S+ VT+ + DVNDN P+F+ PY+ + + L +P T P G
Sbjct: 474 SSSAKVTINVVDVNDNKPVFIVPPYNYSYE--------------------LVLPSTNP-G 512
Query: 138 LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 513 TVVFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 565
Score = 35.9 bits (79), Expect = 1.1
Identities = 18/47 (38%), Positives = 27/47 (57%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
L ATD+D G NA+I Y + + P F++D +G + VV L R+
Sbjct: 305 LMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 351
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 45 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 85
>AJ564961-1|CAD92432.1| 841|Homo sapiens protocadherin protein.
Length = 841
Score = 138 bits (333), Expect = 2e-31
Identities = 138/517 (26%), Positives = 224/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 31 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 83
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 84 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 143
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 144 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 197
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + ++++ + + ++
Sbjct: 198 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLENAAYLDYESTKEYAIK 255
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ Q+ + +
Sbjct: 256 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI--QLMKVSATDA 313
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ +L+ D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 314 DSGPNAEINYLLG--PDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 370
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y+ ++ EN + GT +I TD D G N+
Sbjct: 371 TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 426
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 427 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 484
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 485 DVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAV 521
Score = 116 bits (278), Expect = 9e-25
Identities = 124/424 (29%), Positives = 193/424 (45%), Gaps = 50/424 (11%)
Query: 931 VDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKR 990
V+ + ++ ENIP+ T I + D D+ NG++ + E+ P +L
Sbjct: 181 VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI---PFRLRP---VFSN 234
Query: 991 YFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK 1046
F++ A L ES E+ + + A D G LN + + + VKD ND+ PVF
Sbjct: 235 QFLLEN-------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFT 287
Query: 1047 KTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
+++ ++ E L KV ATDAD G NA + Y + P D F + TG+L+V
Sbjct: 288 QSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGP-DAPPEFSLDRRTGMLTVVK 346
Query: 1107 ELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEAD 1166
+LDRE EDKY+ T++A+DNG D NDNSP F E+K +
Sbjct: 347 KLDREKEDKYLFTILAKDNG-VPPLTSNVTVFVSIIDQNDNSPVF----THNEYKFYVPE 401
Query: 1167 ELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLP-QRKNQQ 1225
L H +V +I V +N+ + T++ + ND I + G+I ++ R+ Q+
Sbjct: 402 NLPRHG--TVGLITVTDPDYGDNSAV--TLSILDENDDFTIDSQTGVIRPNISFDREKQE 457
Query: 1226 NL---------GLPSLSSTAILMVTVADVPDEVEMSDKPVFI----SRYYELEI-EENVN 1271
+ G S SS+A + + V DV D +KPVFI + YEL + N
Sbjct: 458 SYTFYVKAEDGGRVSRSSSAKVTINVVDVND-----NKPVFIVPPYNYSYELVLPSTNPG 512
Query: 1272 APVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEV 1331
V V + N ++RY I+ N D+ F ID G + L+ D + V
Sbjct: 513 TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRV 569
Query: 1332 IVRA 1335
+V+A
Sbjct: 570 LVKA 573
Score = 97.1 bits (231), Expect = 4e-19
Identities = 80/246 (32%), Positives = 107/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G ++K++A D DSG N +I Y
Sbjct: 266 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYL 324
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 325 LGPDA--PPE------------FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 370
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF Y F V E +G + TD D+G N+ +T I
Sbjct: 371 TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 430
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 431 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 487
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 488 DNKPVF 493
Score = 89.4 bits (212), Expect = 9e-17
Identities = 128/492 (26%), Positives = 201/492 (40%), Gaps = 78/492 (15%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P+GT++ +L+A D D G N +I + F++ V S ++ +R F +N G
Sbjct: 78 IPENAPVGTSVTQLHATDADIGENAKIHFSFSNLV----SNIA------RRLFHLNATTG 127
Query: 1000 HVIVARSLPPES--EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTW----YNFN 1053
+ + L E +L + A DGG + V V V DVND+ P + N
Sbjct: 128 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 187
Query: 1054 V--EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGEL 1108
V E + + TD D N +T F +D ++PF + P+ +L L
Sbjct: 188 VVLSENIPLNTKIALITVTDKDADHNGRVTCF---TDHEIPFRLRPVFSNQFLLENAAYL 244
Query: 1109 DRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADEL 1168
D E+ +Y + ++A D G D NDN+P F + PE
Sbjct: 245 DYESTKEYAIKLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPE---- 297
Query: 1169 SNHNFESVMMIPVYKATIEENAPI----GTTVAKVFANDTDFIGNGNGLILYSLPQRKNQ 1224
+N +M + A NA I G F+ D G ++ L + K
Sbjct: 298 NNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDR---RTGMLTVVKKLDREKED 354
Query: 1225 QNL--------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPV 1274
+ L G+P L+S + V++ D D + PVF Y+ + EN+ + V
Sbjct: 355 KYLFTILAKDNGVPPLTSNVTVFVSIIDQND-----NSPVFTHNEYKFYVPENLPRHGTV 409
Query: 1275 ELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVR 1334
L+++ ++ +N + IL+END F ID + G + S DRE +++Y V+
Sbjct: 410 GLITVTDPDYGDNSAVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK 464
Query: 1335 AERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIP 1392
AED KV + + DVNDN P F N +P
Sbjct: 465 -----------------AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP 507
Query: 1393 TTAPFGYQVMQL 1404
+T P G V Q+
Sbjct: 508 STNP-GTVVFQV 518
Score = 83.0 bits (196), Expect = 7e-15
Identities = 53/161 (32%), Positives = 85/161 (52%), Gaps = 9/161 (5%)
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
+ QK LDRE++D Y M V E + G + + + + D NDN PVF+ E I
Sbjct: 21 LIVQKELDREEKDTYVMKVKVE-DGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIP 79
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNA----LFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
EN+ +GT + + ATDAD G NA F + + +F ++ TG++ I + L
Sbjct: 80 ENAPVGTSVTQ---LHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLIT-IKEPL 135
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFN 894
DRE+ +KL ++A D G + + A +++ + D NDN P +
Sbjct: 136 DREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID 176
Score = 78.6 bits (185), Expect = 2e-13
Identities = 101/406 (24%), Positives = 173/406 (42%), Gaps = 58/406 (14%)
Query: 1001 VIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+IV + L E + + + + DGG + ++V V D ND+ PVFK+T ++ E
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPE 80
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP---FEISPLTGVLSVNGELDRETE 1113
+ ++ ATDAD G+NA + + +++ F ++ TG++++ LDRE
Sbjct: 81 NAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREET 140
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE-LSNHN 1172
+ L V+A D G DVNDN P ++ +P D + + N
Sbjct: 141 PNHKLLVLASDGG---LMPARAMVLVNVTDVNDNVPSI----DIRYIVNPVNDTVVLSEN 193
Query: 1173 F---ESVMMIPVYKATIEENA--------PIGTTVAKVFANDTDFIGNGNGLILYSLPQ- 1220
+ +I V + N I + VF+N + N L S +
Sbjct: 194 IPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQF-LLENAAYLDYESTKEY 252
Query: 1221 --RKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVS 1278
+ + G P L+ +A+L + V D E + PVF + + I EN + ++L+
Sbjct: 253 AIKLLAADAGKPPLNQSAMLFIKVKD-----ENDNAPVFTQSFVTVSIPENNSPGIQLMK 307
Query: 1279 LNLT--EHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAE 1336
++ T + N ++ Y + D F +D R G L +V+ DRE +D Y + A+
Sbjct: 308 VSATDADSGPNAEINYLL----GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK 363
Query: 1337 RQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTN 1382
+ + P+ +V V V I D NDNSP FT+
Sbjct: 364 --------DNGVPPLTS---------NVTVFVSIIDQNDNSPVFTH 392
Score = 74.1 bits (174), Expect = 3e-12
Identities = 51/168 (30%), Positives = 78/168 (46%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 308 VSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKE-----DKYLFTIL 361
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + Y + ENLP +V + TD D G+
Sbjct: 362 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGD 421
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 422 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 467
Score = 70.1 bits (164), Expect = 6e-11
Identities = 46/137 (33%), Positives = 65/137 (47%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 233 SNQFLLENAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 289
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G +++V ATD D G N E Y L D FS+D R+G LTV +
Sbjct: 290 FVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKK-- 347
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 348 LDREKEDKYLFTILAKD 364
Score = 64.9 bits (151), Expect = 2e-09
Identities = 41/138 (29%), Positives = 74/138 (53%), Gaps = 12/138 (8%)
Query: 253 LFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN 312
L ++KELD + + +T+V++V+ P +++ A +++ + D NDN P F+
Sbjct: 21 LIVQKELDRE-----EKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 75
Query: 313 ISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQT 367
+SI EN P G SV Q+ ATD D GEN + + + + F ++ +G +T++
Sbjct: 76 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP- 134
Query: 368 VLDREAHSSLRMKVYAKE 385
LDRE + ++ V A +
Sbjct: 135 -LDREETPNHKLLVLASD 151
Score = 62.1 bits (144), Expect = 1e-08
Identities = 51/178 (28%), Positives = 86/178 (48%), Gaps = 18/178 (10%)
Query: 218 IHAIDQDLGVGATLRYE---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
+HA D D+G A + + L+S R+LF L++ G + +++ LD + N + L
Sbjct: 91 LHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----L 145
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQV 328
V AS + L A+A V + + D+NDN+P ++ + N ++V EN+P + +
Sbjct: 146 LVLAS--DGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 203
Query: 329 MATDKDQGENGEFTYQLDDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TDKD NG T D + F + P S + N LD E+ +K+ A +
Sbjct: 204 TVTDKDADHNGRVTC-FTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAAD 260
Score = 62.1 bits (144), Expect = 1e-08
Identities = 49/166 (29%), Positives = 78/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 412 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 464
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V YN S LP+ G V QV+A D D
Sbjct: 465 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDND 524
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 525 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 570
Score = 50.4 bits (115), Expect = 5e-05
Identities = 39/124 (31%), Positives = 62/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ P N YE + S GTV+ +V AVD D G N V Y
Sbjct: 475 SSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 533
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 534 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 588
Query: 556 TIEV 559
+ V
Sbjct: 589 NLFV 592
Score = 48.0 bits (109), Expect = 3e-04
Identities = 47/166 (28%), Positives = 71/166 (42%), Gaps = 12/166 (7%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEH--Y 1285
G P SSTAIL V+V D D + PVF E+ I EN + L+ T+
Sbjct: 45 GFPQRSSTAILQVSVTDTND-----NHPVFKETEIEVSIPENAPVGTSVTQLHATDADIG 99
Query: 1286 ENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
EN K+ + N RR F ++ G + + DRE ++++V A
Sbjct: 100 ENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARA 159
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAI 1391
++ V DV + + D++ +V VND + N PL T I
Sbjct: 160 MVLVNVT-DVNDNVPSIDIRYIV--NPVNDT--VVLSENIPLNTKI 200
Score = 40.7 bits (91), Expect = 0.039
Identities = 36/116 (31%), Positives = 53/116 (45%), Gaps = 24/116 (20%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRG 137
S+ VT+ + DVNDN P+F+ PY+ + + L +P T P G
Sbjct: 474 SSSAKVTINVVDVNDNKPVFIVPPYNYSYE--------------------LVLPSTNP-G 512
Query: 138 LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 513 TVVFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 565
Score = 35.9 bits (79), Expect = 1.1
Identities = 18/47 (38%), Positives = 27/47 (57%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
L ATD+D G NA+I Y + + P F++D +G + VV L R+
Sbjct: 305 LMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 351
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 45 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 85
>AJ564960-1|CAD92431.1| 831|Homo sapiens protocadherin protein.
Length = 831
Score = 138 bits (333), Expect = 2e-31
Identities = 138/517 (26%), Positives = 224/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 31 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 83
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 84 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 143
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 144 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 197
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + ++++ + + ++
Sbjct: 198 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLENAAYLDYESTKEYAIK 255
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ Q+ + +
Sbjct: 256 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI--QLMKVSATDA 313
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ +L+ D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 314 DSGPNAEINYLLG--PDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 370
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y+ ++ EN + GT +I TD D G N+
Sbjct: 371 TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 426
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 427 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 484
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 485 DVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAV 521
Score = 116 bits (278), Expect = 9e-25
Identities = 124/424 (29%), Positives = 193/424 (45%), Gaps = 50/424 (11%)
Query: 931 VDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKR 990
V+ + ++ ENIP+ T I + D D+ NG++ + E+ P +L
Sbjct: 181 VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI---PFRLRP---VFSN 234
Query: 991 YFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK 1046
F++ A L ES E+ + + A D G LN + + + VKD ND+ PVF
Sbjct: 235 QFLLEN-------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFT 287
Query: 1047 KTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
+++ ++ E L KV ATDAD G NA + Y + P D F + TG+L+V
Sbjct: 288 QSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGP-DAPPEFSLDRRTGMLTVVK 346
Query: 1107 ELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEAD 1166
+LDRE EDKY+ T++A+DNG D NDNSP F E+K +
Sbjct: 347 KLDREKEDKYLFTILAKDNG-VPPLTSNVTVFVSIIDQNDNSPVF----THNEYKFYVPE 401
Query: 1167 ELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLP-QRKNQQ 1225
L H +V +I V +N+ + T++ + ND I + G+I ++ R+ Q+
Sbjct: 402 NLPRHG--TVGLITVTDPDYGDNSAV--TLSILDENDDFTIDSQTGVIRPNISFDREKQE 457
Query: 1226 NL---------GLPSLSSTAILMVTVADVPDEVEMSDKPVFI----SRYYELEI-EENVN 1271
+ G S SS+A + + V DV D +KPVFI + YEL + N
Sbjct: 458 SYTFYVKAEDGGRVSRSSSAKVTINVVDVND-----NKPVFIVPPYNYSYELVLPSTNPG 512
Query: 1272 APVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEV 1331
V V + N ++RY I+ N D+ F ID G + L+ D + V
Sbjct: 513 TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRV 569
Query: 1332 IVRA 1335
+V+A
Sbjct: 570 LVKA 573
Score = 97.1 bits (231), Expect = 4e-19
Identities = 80/246 (32%), Positives = 107/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G ++K++A D DSG N +I Y
Sbjct: 266 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYL 324
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 325 LGPDA--PPE------------FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 370
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF Y F V E +G + TD D+G N+ +T I
Sbjct: 371 TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 430
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 431 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 487
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 488 DNKPVF 493
Score = 89.4 bits (212), Expect = 9e-17
Identities = 128/492 (26%), Positives = 201/492 (40%), Gaps = 78/492 (15%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P+GT++ +L+A D D G N +I + F++ V S ++ +R F +N G
Sbjct: 78 IPENAPVGTSVTQLHATDADIGENAKIHFSFSNLV----SNIA------RRLFHLNATTG 127
Query: 1000 HVIVARSLPPES--EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTW----YNFN 1053
+ + L E +L + A DGG + V V V DVND+ P + N
Sbjct: 128 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 187
Query: 1054 V--EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGEL 1108
V E + + TD D N +T F +D ++PF + P+ +L L
Sbjct: 188 VVLSENIPLNTKIALITVTDKDADHNGRVTCF---TDHEIPFRLRPVFSNQFLLENAAYL 244
Query: 1109 DRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADEL 1168
D E+ +Y + ++A D G D NDN+P F + PE
Sbjct: 245 DYESTKEYAIKLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPE---- 297
Query: 1169 SNHNFESVMMIPVYKATIEENAPI----GTTVAKVFANDTDFIGNGNGLILYSLPQRKNQ 1224
+N +M + A NA I G F+ D G ++ L + K
Sbjct: 298 NNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDR---RTGMLTVVKKLDREKED 354
Query: 1225 QNL--------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPV 1274
+ L G+P L+S + V++ D D + PVF Y+ + EN+ + V
Sbjct: 355 KYLFTILAKDNGVPPLTSNVTVFVSIIDQND-----NSPVFTHNEYKFYVPENLPRHGTV 409
Query: 1275 ELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVR 1334
L+++ ++ +N + IL+END F ID + G + S DRE +++Y V+
Sbjct: 410 GLITVTDPDYGDNSAVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK 464
Query: 1335 AERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIP 1392
AED KV + + DVNDN P F N +P
Sbjct: 465 -----------------AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP 507
Query: 1393 TTAPFGYQVMQL 1404
+T P G V Q+
Sbjct: 508 STNP-GTVVFQV 518
Score = 83.0 bits (196), Expect = 7e-15
Identities = 53/161 (32%), Positives = 85/161 (52%), Gaps = 9/161 (5%)
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
+ QK LDRE++D Y M V E + G + + + + D NDN PVF+ E I
Sbjct: 21 LIVQKELDREEKDTYVMKVKVE-DGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIP 79
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNA----LFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
EN+ +GT + + ATDAD G NA F + + +F ++ TG++ I + L
Sbjct: 80 ENAPVGTSVTQ---LHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLIT-IKEPL 135
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFN 894
DRE+ +KL ++A D G + + A +++ + D NDN P +
Sbjct: 136 DREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID 176
Score = 78.6 bits (185), Expect = 2e-13
Identities = 101/406 (24%), Positives = 173/406 (42%), Gaps = 58/406 (14%)
Query: 1001 VIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+IV + L E + + + + DGG + ++V V D ND+ PVFK+T ++ E
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPE 80
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP---FEISPLTGVLSVNGELDRETE 1113
+ ++ ATDAD G+NA + + +++ F ++ TG++++ LDRE
Sbjct: 81 NAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREET 140
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE-LSNHN 1172
+ L V+A D G DVNDN P ++ +P D + + N
Sbjct: 141 PNHKLLVLASDGG---LMPARAMVLVNVTDVNDNVPSI----DIRYIVNPVNDTVVLSEN 193
Query: 1173 F---ESVMMIPVYKATIEENA--------PIGTTVAKVFANDTDFIGNGNGLILYSLPQ- 1220
+ +I V + N I + VF+N + N L S +
Sbjct: 194 IPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQF-LLENAAYLDYESTKEY 252
Query: 1221 --RKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVS 1278
+ + G P L+ +A+L + V D E + PVF + + I EN + ++L+
Sbjct: 253 AIKLLAADAGKPPLNQSAMLFIKVKD-----ENDNAPVFTQSFVTVSIPENNSPGIQLMK 307
Query: 1279 LNLT--EHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAE 1336
++ T + N ++ Y + D F +D R G L +V+ DRE +D Y + A+
Sbjct: 308 VSATDADSGPNAEINYLL----GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK 363
Query: 1337 RQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTN 1382
+ + P+ +V V V I D NDNSP FT+
Sbjct: 364 --------DNGVPPLTS---------NVTVFVSIIDQNDNSPVFTH 392
Score = 74.1 bits (174), Expect = 3e-12
Identities = 51/168 (30%), Positives = 78/168 (46%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 308 VSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKE-----DKYLFTIL 361
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + Y + ENLP +V + TD D G+
Sbjct: 362 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGD 421
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 422 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 467
Score = 70.1 bits (164), Expect = 6e-11
Identities = 46/137 (33%), Positives = 65/137 (47%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 233 SNQFLLENAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 289
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G +++V ATD D G N E Y L D FS+D R+G LTV +
Sbjct: 290 FVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKK-- 347
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 348 LDREKEDKYLFTILAKD 364
Score = 64.9 bits (151), Expect = 2e-09
Identities = 41/138 (29%), Positives = 74/138 (53%), Gaps = 12/138 (8%)
Query: 253 LFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN 312
L ++KELD + + +T+V++V+ P +++ A +++ + D NDN P F+
Sbjct: 21 LIVQKELDRE-----EKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 75
Query: 313 ISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQT 367
+SI EN P G SV Q+ ATD D GEN + + + + F ++ +G +T++
Sbjct: 76 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP- 134
Query: 368 VLDREAHSSLRMKVYAKE 385
LDRE + ++ V A +
Sbjct: 135 -LDREETPNHKLLVLASD 151
Score = 62.1 bits (144), Expect = 1e-08
Identities = 51/178 (28%), Positives = 86/178 (48%), Gaps = 18/178 (10%)
Query: 218 IHAIDQDLGVGATLRYE---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
+HA D D+G A + + L+S R+LF L++ G + +++ LD + N + L
Sbjct: 91 LHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----L 145
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQV 328
V AS + L A+A V + + D+NDN+P ++ + N ++V EN+P + +
Sbjct: 146 LVLAS--DGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 203
Query: 329 MATDKDQGENGEFTYQLDDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TDKD NG T D + F + P S + N LD E+ +K+ A +
Sbjct: 204 TVTDKDADHNGRVTC-FTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAAD 260
Score = 62.1 bits (144), Expect = 1e-08
Identities = 49/166 (29%), Positives = 78/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 412 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 464
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V YN S LP+ G V QV+A D D
Sbjct: 465 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDND 524
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 525 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 570
Score = 50.4 bits (115), Expect = 5e-05
Identities = 39/124 (31%), Positives = 62/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ P N YE + S GTV+ +V AVD D G N V Y
Sbjct: 475 SSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 533
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 534 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 588
Query: 556 TIEV 559
+ V
Sbjct: 589 NLFV 592
Score = 48.0 bits (109), Expect = 3e-04
Identities = 47/166 (28%), Positives = 71/166 (42%), Gaps = 12/166 (7%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEH--Y 1285
G P SSTAIL V+V D D + PVF E+ I EN + L+ T+
Sbjct: 45 GFPQRSSTAILQVSVTDTND-----NHPVFKETEIEVSIPENAPVGTSVTQLHATDADIG 99
Query: 1286 ENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
EN K+ + N RR F ++ G + + DRE ++++V A
Sbjct: 100 ENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARA 159
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAI 1391
++ V DV + + D++ +V VND + N PL T I
Sbjct: 160 MVLVNVT-DVNDNVPSIDIRYIV--NPVNDT--VVLSENIPLNTKI 200
Score = 40.7 bits (91), Expect = 0.039
Identities = 36/116 (31%), Positives = 53/116 (45%), Gaps = 24/116 (20%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRG 137
S+ VT+ + DVNDN P+F+ PY+ + + L +P T P G
Sbjct: 474 SSSAKVTINVVDVNDNKPVFIVPPYNYSYE--------------------LVLPSTNP-G 512
Query: 138 LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 513 TVVFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 565
Score = 35.9 bits (79), Expect = 1.1
Identities = 18/47 (38%), Positives = 27/47 (57%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
L ATD+D G NA+I Y + + P F++D +G + VV L R+
Sbjct: 305 LMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 351
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 45 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 85
>AJ564936-1|CAD92415.1| 787|Homo sapiens protocadherin protein.
Length = 787
Score = 138 bits (333), Expect = 2e-31
Identities = 140/517 (27%), Positives = 223/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 31 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 83
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 84 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 143
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 144 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 197
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + +++ + + ++
Sbjct: 198 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 255
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ I T +S++
Sbjct: 256 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG----IQLTKVSAM 311
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ N + D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 312 DADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 370
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y ++ EN + GT +I TD D G N+
Sbjct: 371 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 426
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 427 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 484
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 485 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 521
Score = 97.9 bits (233), Expect = 2e-19
Identities = 81/246 (32%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G + K++A+D DSG N +I Y
Sbjct: 266 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYL 324
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 325 LGPDA--PPE------------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 370
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF YNF V E +G + TD D+G N+ +T I
Sbjct: 371 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 430
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 431 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 487
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 488 DNKPVF 493
Score = 90.2 bits (214), Expect = 5e-17
Identities = 124/488 (25%), Positives = 197/488 (40%), Gaps = 70/488 (14%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P+GT++ +L+A D D G N +I + F++ V S ++ +R F +N G
Sbjct: 78 IPENAPVGTSVTQLHATDADIGENAKIHFSFSNLV----SNIA------RRLFHLNATTG 127
Query: 1000 HVIVARSLPPES--EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTW----YNFN 1053
+ + L E +L + A DGG + V V V DVND+ P + N
Sbjct: 128 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 187
Query: 1054 V--EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGEL 1108
V E + + TD D N +T F +D ++PF + P+ +L L
Sbjct: 188 VVLSENIPLNTKIALITVTDKDADHNGRVTCF---TDHEIPFRLRPVFSNQFLLETAAYL 244
Query: 1109 DRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADEL 1168
D E+ +Y + ++A D G D NDN+P F + PE +
Sbjct: 245 DYESTKEYAIKLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPENNSP 301
Query: 1169 SNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL- 1227
+ M + N +G F+ D G ++ L + K + L
Sbjct: 302 GIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLD---CRTGMLTVVKKLDREKEDKYLF 358
Query: 1228 -------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVS 1278
G+P L+S + V++ D D + PVF Y + EN+ + V L++
Sbjct: 359 TILAKDNGVPPLTSNVTVFVSIIDQND-----NSPVFTHNEYNFYVPENLPRHGTVGLIT 413
Query: 1279 LNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
+ ++ +N + IL+END F ID + G + S DRE +++Y V+
Sbjct: 414 VTDPDYGDNSAVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK---- 464
Query: 1339 KYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAP 1396
AED KV + + DVNDN P F N +P+T P
Sbjct: 465 -------------AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP 511
Query: 1397 FGYQVMQL 1404
G V Q+
Sbjct: 512 -GTVVFQV 518
Score = 83.0 bits (196), Expect = 7e-15
Identities = 53/161 (32%), Positives = 85/161 (52%), Gaps = 9/161 (5%)
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
+ QK LDRE++D Y M V E + G + + + + D NDN PVF+ E I
Sbjct: 21 LIVQKELDREEKDTYVMKVKVE-DGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIP 79
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNA----LFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
EN+ +GT + + ATDAD G NA F + + +F ++ TG++ I + L
Sbjct: 80 ENAPVGTSVTQ---LHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLIT-IKEPL 135
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFN 894
DRE+ +KL ++A D G + + A +++ + D NDN P +
Sbjct: 136 DREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID 176
Score = 77.4 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 308 VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE-----DKYLFTIL 361
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + YN + ENLP +V + TD D G+
Sbjct: 362 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 421
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 422 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 467
Score = 64.9 bits (151), Expect = 2e-09
Identities = 41/138 (29%), Positives = 74/138 (53%), Gaps = 12/138 (8%)
Query: 253 LFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN 312
L ++KELD + + +T+V++V+ P +++ A +++ + D NDN P F+
Sbjct: 21 LIVQKELDRE-----EKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 75
Query: 313 ISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQT 367
+SI EN P G SV Q+ ATD D GEN + + + + F ++ +G +T++
Sbjct: 76 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP- 134
Query: 368 VLDREAHSSLRMKVYAKE 385
LDRE + ++ V A +
Sbjct: 135 -LDREETPNHKLLVLASD 151
Score = 64.1 bits (149), Expect = 4e-09
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 233 SNQFLLETAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 289
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G + +V A D D G N + Y L D FS+D R+G LTV +
Sbjct: 290 FVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-- 347
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 348 LDREKEDKYLFTILAKD 364
Score = 62.5 bits (145), Expect = 1e-08
Identities = 44/156 (28%), Positives = 74/156 (47%), Gaps = 10/156 (6%)
Query: 1001 VIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+IV + L E + + + + DGG + ++V V D ND+ PVFK+T ++ E
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPE 80
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP---FEISPLTGVLSVNGELDRETE 1113
+ ++ ATDAD G+NA + + +++ F ++ TG++++ LDRE
Sbjct: 81 NAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREET 140
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
+ L V+A D G DVNDN P
Sbjct: 141 PNHKLLVLASDGG---LMPARAMVLVNVTDVNDNVP 173
Score = 59.7 bits (138), Expect = 8e-08
Identities = 50/178 (28%), Positives = 85/178 (47%), Gaps = 18/178 (10%)
Query: 218 IHAIDQDLGVGATLRYE---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
+HA D D+G A + + L+S R+LF L++ G + +++ LD + N + L
Sbjct: 91 LHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----L 145
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQV 328
V AS + L A+A V + + D+NDN+P ++ + N ++V EN+P + +
Sbjct: 146 LVLAS--DGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 203
Query: 329 MATDKDQGENGEFTYQLDDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TDKD NG T D + F + P S + LD E+ +K+ A +
Sbjct: 204 TVTDKDADHNGRVTC-FTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAAD 260
Score = 58.4 bits (135), Expect = 2e-07
Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 412 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 464
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V N S LP+ G V QV+A D D
Sbjct: 465 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDND 524
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 525 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 570
Score = 52.8 bits (121), Expect = 9e-06
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ PSN YE + S GTV+ +V AVD D G N V Y
Sbjct: 475 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 533
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 534 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 588
Query: 556 TIEV 559
+ V
Sbjct: 589 NLFV 592
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/206 (24%), Positives = 93/206 (45%), Gaps = 27/206 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSLTI 130
G+ +++ ++V V I D NDN P+F Y+ V E P G I + P G + +
Sbjct: 366 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 425
Query: 131 PL---------TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L T+ + + +FDR+K + + V D G + SS K
Sbjct: 426 TLSILDENDDFTIDSQTGVIRPNISFDREKQES-----YTFYVKAEDGGRVSRSSSAKVT 480
Query: 182 LLLRKVLD------YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
+ + V D + ++LV+ ++ ++F + A+D D G+ A +RY +
Sbjct: 481 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT---VVFQ--VIAVDNDTGMNAEVRYSI 535
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDL 261
+ GN R LF++D G++ L ++ D+
Sbjct: 536 VGGNTRDLFAIDQETGNITLMEKCDV 561
Score = 48.0 bits (109), Expect = 3e-04
Identities = 47/166 (28%), Positives = 71/166 (42%), Gaps = 12/166 (7%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEH--Y 1285
G P SSTAIL V+V D D + PVF E+ I EN + L+ T+
Sbjct: 45 GFPQRSSTAILQVSVTDTND-----NHPVFKETEIEVSIPENAPVGTSVTQLHATDADIG 99
Query: 1286 ENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
EN K+ + N RR F ++ G + + DRE ++++V A
Sbjct: 100 ENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARA 159
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAI 1391
++ V DV + + D++ +V VND + N PL T I
Sbjct: 160 MVLVNVT-DVNDNVPSIDIRYIV--NPVNDT--VVLSENIPLNTKI 200
Score = 37.9 bits (84), Expect = 0.28
Identities = 75/327 (22%), Positives = 126/327 (38%), Gaps = 63/327 (19%)
Query: 1102 LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWK 1161
L V ELDRE +D Y++ V D G D NDN
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVT-DTNDN-------------- 65
Query: 1162 HPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQR 1221
HP E + +I ENAP+GT+V ++ A D D IG N I +S
Sbjct: 66 HPVFKETE------------IEVSIPENAPVGTSVTQLHATDAD-IGE-NAKIHFSFSNL 111
Query: 1222 KNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL 1281
+ L L++T L +T+ + D E + + + L + + +V +N+
Sbjct: 112 VSNIARRLFHLNATTGL-ITIKEPLDREETPNHKLLV-----LASDGGLMPARAMVLVNV 165
Query: 1282 TEHYEN---FKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
T+ +N +RY + NDT + + P N + L+ D++ V + +
Sbjct: 166 TDVNDNVPSIDIRYIVNPVNDTVVLSENI--PLNTKIALITVTDKDADHNGRVTCFTDHE 223
Query: 1339 KYSRELP-----HMIYPVAEDVLEGMTKYDVKVV----------------VRIKDVNDNS 1377
R P ++ A E +Y +K++ +++KD NDN+
Sbjct: 224 IPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 283
Query: 1378 PKFTNGNRPLVTAIPTTAPFGYQVMQL 1404
P FT + +IP G Q+ ++
Sbjct: 284 PVFTQSF--VTVSIPENNSPGIQLTKV 308
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/114 (29%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS--LTIPLTVPRGLT 139
S T Y++ D + + VT++ + K +F++ P S L +P T P G
Sbjct: 458 SYTFYVK-AEDGGRVSRSSSAKVTINVVDVNDNKP-VFIVPPSNCSYELVLPSTNP-GTV 514
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 515 VFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 565
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
LT A D+D G NA I Y + + P F++D +G + VV L R+
Sbjct: 305 LTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 351
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 45 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 85
>AJ564935-1|CAD92414.1| 762|Homo sapiens protocadherin protein.
Length = 762
Score = 138 bits (333), Expect = 2e-31
Identities = 140/517 (27%), Positives = 223/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 31 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 83
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 84 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 143
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 144 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 197
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + +++ + + ++
Sbjct: 198 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 255
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ I T +S++
Sbjct: 256 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG----IQLTKVSAM 311
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ N + D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 312 DADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 370
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y ++ EN + GT +I TD D G N+
Sbjct: 371 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 426
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 427 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 484
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 485 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 521
Score = 97.9 bits (233), Expect = 2e-19
Identities = 81/246 (32%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G + K++A+D DSG N +I Y
Sbjct: 266 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYL 324
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 325 LGPDA--PPE------------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 370
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF YNF V E +G + TD D+G N+ +T I
Sbjct: 371 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 430
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 431 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 487
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 488 DNKPVF 493
Score = 90.2 bits (214), Expect = 5e-17
Identities = 124/488 (25%), Positives = 197/488 (40%), Gaps = 70/488 (14%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P+GT++ +L+A D D G N +I + F++ V S ++ +R F +N G
Sbjct: 78 IPENAPVGTSVTQLHATDADIGENAKIHFSFSNLV----SNIA------RRLFHLNATTG 127
Query: 1000 HVIVARSLPPES--EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTW----YNFN 1053
+ + L E +L + A DGG + V V V DVND+ P + N
Sbjct: 128 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 187
Query: 1054 V--EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGEL 1108
V E + + TD D N +T F +D ++PF + P+ +L L
Sbjct: 188 VVLSENIPLNTKIALITVTDKDADHNGRVTCF---TDHEIPFRLRPVFSNQFLLETAAYL 244
Query: 1109 DRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADEL 1168
D E+ +Y + ++A D G D NDN+P F + PE +
Sbjct: 245 DYESTKEYAIKLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPENNSP 301
Query: 1169 SNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL- 1227
+ M + N +G F+ D G ++ L + K + L
Sbjct: 302 GIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLD---CRTGMLTVVKKLDREKEDKYLF 358
Query: 1228 -------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVS 1278
G+P L+S + V++ D D + PVF Y + EN+ + V L++
Sbjct: 359 TILAKDNGVPPLTSNVTVFVSIIDQND-----NSPVFTHNEYNFYVPENLPRHGTVGLIT 413
Query: 1279 LNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
+ ++ +N + IL+END F ID + G + S DRE +++Y V+
Sbjct: 414 VTDPDYGDNSAVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK---- 464
Query: 1339 KYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAP 1396
AED KV + + DVNDN P F N +P+T P
Sbjct: 465 -------------AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP 511
Query: 1397 FGYQVMQL 1404
G V Q+
Sbjct: 512 -GTVVFQV 518
Score = 83.0 bits (196), Expect = 7e-15
Identities = 53/161 (32%), Positives = 85/161 (52%), Gaps = 9/161 (5%)
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
+ QK LDRE++D Y M V E + G + + + + D NDN PVF+ E I
Sbjct: 21 LIVQKELDREEKDTYVMKVKVE-DGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIP 79
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNA----LFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
EN+ +GT + + ATDAD G NA F + + +F ++ TG++ I + L
Sbjct: 80 ENAPVGTSVTQ---LHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLIT-IKEPL 135
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFN 894
DRE+ +KL ++A D G + + A +++ + D NDN P +
Sbjct: 136 DREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID 176
Score = 77.4 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 308 VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE-----DKYLFTIL 361
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + YN + ENLP +V + TD D G+
Sbjct: 362 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 421
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 422 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 467
Score = 64.9 bits (151), Expect = 2e-09
Identities = 41/138 (29%), Positives = 74/138 (53%), Gaps = 12/138 (8%)
Query: 253 LFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN 312
L ++KELD + + +T+V++V+ P +++ A +++ + D NDN P F+
Sbjct: 21 LIVQKELDRE-----EKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 75
Query: 313 ISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQT 367
+SI EN P G SV Q+ ATD D GEN + + + + F ++ +G +T++
Sbjct: 76 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP- 134
Query: 368 VLDREAHSSLRMKVYAKE 385
LDRE + ++ V A +
Sbjct: 135 -LDREETPNHKLLVLASD 151
Score = 64.1 bits (149), Expect = 4e-09
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 233 SNQFLLETAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 289
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G + +V A D D G N + Y L D FS+D R+G LTV +
Sbjct: 290 FVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-- 347
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 348 LDREKEDKYLFTILAKD 364
Score = 62.5 bits (145), Expect = 1e-08
Identities = 44/156 (28%), Positives = 74/156 (47%), Gaps = 10/156 (6%)
Query: 1001 VIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+IV + L E + + + + DGG + ++V V D ND+ PVFK+T ++ E
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPE 80
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP---FEISPLTGVLSVNGELDRETE 1113
+ ++ ATDAD G+NA + + +++ F ++ TG++++ LDRE
Sbjct: 81 NAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREET 140
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
+ L V+A D G DVNDN P
Sbjct: 141 PNHKLLVLASDGG---LMPARAMVLVNVTDVNDNVP 173
Score = 59.7 bits (138), Expect = 8e-08
Identities = 50/178 (28%), Positives = 85/178 (47%), Gaps = 18/178 (10%)
Query: 218 IHAIDQDLGVGATLRYE---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
+HA D D+G A + + L+S R+LF L++ G + +++ LD + N + L
Sbjct: 91 LHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----L 145
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQV 328
V AS + L A+A V + + D+NDN+P ++ + N ++V EN+P + +
Sbjct: 146 LVLAS--DGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 203
Query: 329 MATDKDQGENGEFTYQLDDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TDKD NG T D + F + P S + LD E+ +K+ A +
Sbjct: 204 TVTDKDADHNGRVTC-FTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAAD 260
Score = 58.4 bits (135), Expect = 2e-07
Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 412 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 464
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V N S LP+ G V QV+A D D
Sbjct: 465 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDND 524
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 525 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 570
Score = 52.8 bits (121), Expect = 9e-06
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ PSN YE + S GTV+ +V AVD D G N V Y
Sbjct: 475 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 533
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 534 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 588
Query: 556 TIEV 559
+ V
Sbjct: 589 NLFV 592
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/206 (24%), Positives = 93/206 (45%), Gaps = 27/206 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSLTI 130
G+ +++ ++V V I D NDN P+F Y+ V E P G I + P G + +
Sbjct: 366 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 425
Query: 131 PL---------TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L T+ + + +FDR+K + + V D G + SS K
Sbjct: 426 TLSILDENDDFTIDSQTGVIRPNISFDREKQES-----YTFYVKAEDGGRVSRSSSAKVT 480
Query: 182 LLLRKVLD------YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
+ + V D + ++LV+ ++ ++F + A+D D G+ A +RY +
Sbjct: 481 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT---VVFQ--VIAVDNDTGMNAEVRYSI 535
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDL 261
+ GN R LF++D G++ L ++ D+
Sbjct: 536 VGGNTRDLFAIDQETGNITLMEKCDV 561
Score = 48.0 bits (109), Expect = 3e-04
Identities = 47/166 (28%), Positives = 71/166 (42%), Gaps = 12/166 (7%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEH--Y 1285
G P SSTAIL V+V D D + PVF E+ I EN + L+ T+
Sbjct: 45 GFPQRSSTAILQVSVTDTND-----NHPVFKETEIEVSIPENAPVGTSVTQLHATDADIG 99
Query: 1286 ENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
EN K+ + N RR F ++ G + + DRE ++++V A
Sbjct: 100 ENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARA 159
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAI 1391
++ V DV + + D++ +V VND + N PL T I
Sbjct: 160 MVLVNVT-DVNDNVPSIDIRYIV--NPVNDT--VVLSENIPLNTKI 200
Score = 37.9 bits (84), Expect = 0.28
Identities = 75/327 (22%), Positives = 126/327 (38%), Gaps = 63/327 (19%)
Query: 1102 LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWK 1161
L V ELDRE +D Y++ V D G D NDN
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVT-DTNDN-------------- 65
Query: 1162 HPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQR 1221
HP E + +I ENAP+GT+V ++ A D D IG N I +S
Sbjct: 66 HPVFKETE------------IEVSIPENAPVGTSVTQLHATDAD-IGE-NAKIHFSFSNL 111
Query: 1222 KNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL 1281
+ L L++T L +T+ + D E + + + L + + +V +N+
Sbjct: 112 VSNIARRLFHLNATTGL-ITIKEPLDREETPNHKLLV-----LASDGGLMPARAMVLVNV 165
Query: 1282 TEHYEN---FKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
T+ +N +RY + NDT + + P N + L+ D++ V + +
Sbjct: 166 TDVNDNVPSIDIRYIVNPVNDTVVLSENI--PLNTKIALITVTDKDADHNGRVTCFTDHE 223
Query: 1339 KYSRELP-----HMIYPVAEDVLEGMTKYDVKVV----------------VRIKDVNDNS 1377
R P ++ A E +Y +K++ +++KD NDN+
Sbjct: 224 IPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 283
Query: 1378 PKFTNGNRPLVTAIPTTAPFGYQVMQL 1404
P FT + +IP G Q+ ++
Sbjct: 284 PVFTQSF--VTVSIPENNSPGIQLTKV 308
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/114 (29%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS--LTIPLTVPRGLT 139
S T Y++ D + + VT++ + K +F++ P S L +P T P G
Sbjct: 458 SYTFYVK-AEDGGRVSRSSSAKVTINVVDVNDNKP-VFIVPPSNCSYELVLPSTNP-GTV 514
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 515 VFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 565
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
LT A D+D G NA I Y + + P F++D +G + VV L R+
Sbjct: 305 LTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 351
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 45 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 85
>AJ564934-1|CAD92413.1| 841|Homo sapiens protocadherin protein.
Length = 841
Score = 138 bits (333), Expect = 2e-31
Identities = 140/517 (27%), Positives = 223/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 31 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 83
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 84 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 143
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 144 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 197
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + +++ + + ++
Sbjct: 198 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 255
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ I T +S++
Sbjct: 256 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG----IQLTKVSAM 311
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ N + D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 312 DADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 370
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y ++ EN + GT +I TD D G N+
Sbjct: 371 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 426
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 427 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 484
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 485 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 521
Score = 97.9 bits (233), Expect = 2e-19
Identities = 81/246 (32%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G + K++A+D DSG N +I Y
Sbjct: 266 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYL 324
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 325 LGPDA--PPE------------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 370
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF YNF V E +G + TD D+G N+ +T I
Sbjct: 371 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 430
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 431 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 487
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 488 DNKPVF 493
Score = 90.2 bits (214), Expect = 5e-17
Identities = 124/488 (25%), Positives = 197/488 (40%), Gaps = 70/488 (14%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P+GT++ +L+A D D G N +I + F++ V S ++ +R F +N G
Sbjct: 78 IPENAPVGTSVTQLHATDADIGENAKIHFSFSNLV----SNIA------RRLFHLNATTG 127
Query: 1000 HVIVARSLPPES--EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTW----YNFN 1053
+ + L E +L + A DGG + V V V DVND+ P + N
Sbjct: 128 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 187
Query: 1054 V--EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGEL 1108
V E + + TD D N +T F +D ++PF + P+ +L L
Sbjct: 188 VVLSENIPLNTKIALITVTDKDADHNGRVTCF---TDHEIPFRLRPVFSNQFLLETAAYL 244
Query: 1109 DRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADEL 1168
D E+ +Y + ++A D G D NDN+P F + PE +
Sbjct: 245 DYESTKEYAIKLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPENNSP 301
Query: 1169 SNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL- 1227
+ M + N +G F+ D G ++ L + K + L
Sbjct: 302 GIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLD---CRTGMLTVVKKLDREKEDKYLF 358
Query: 1228 -------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVS 1278
G+P L+S + V++ D D + PVF Y + EN+ + V L++
Sbjct: 359 TILAKDNGVPPLTSNVTVFVSIIDQND-----NSPVFTHNEYNFYVPENLPRHGTVGLIT 413
Query: 1279 LNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
+ ++ +N + IL+END F ID + G + S DRE +++Y V+
Sbjct: 414 VTDPDYGDNSAVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK---- 464
Query: 1339 KYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAP 1396
AED KV + + DVNDN P F N +P+T P
Sbjct: 465 -------------AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP 511
Query: 1397 FGYQVMQL 1404
G V Q+
Sbjct: 512 -GTVVFQV 518
Score = 83.0 bits (196), Expect = 7e-15
Identities = 53/161 (32%), Positives = 85/161 (52%), Gaps = 9/161 (5%)
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
+ QK LDRE++D Y M V E + G + + + + D NDN PVF+ E I
Sbjct: 21 LIVQKELDREEKDTYVMKVKVE-DGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIP 79
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNA----LFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
EN+ +GT + + ATDAD G NA F + + +F ++ TG++ I + L
Sbjct: 80 ENAPVGTSVTQ---LHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLIT-IKEPL 135
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFN 894
DRE+ +KL ++A D G + + A +++ + D NDN P +
Sbjct: 136 DREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID 176
Score = 77.4 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 308 VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE-----DKYLFTIL 361
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + YN + ENLP +V + TD D G+
Sbjct: 362 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 421
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 422 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 467
Score = 64.9 bits (151), Expect = 2e-09
Identities = 41/138 (29%), Positives = 74/138 (53%), Gaps = 12/138 (8%)
Query: 253 LFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN 312
L ++KELD + + +T+V++V+ P +++ A +++ + D NDN P F+
Sbjct: 21 LIVQKELDRE-----EKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 75
Query: 313 ISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQT 367
+SI EN P G SV Q+ ATD D GEN + + + + F ++ +G +T++
Sbjct: 76 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP- 134
Query: 368 VLDREAHSSLRMKVYAKE 385
LDRE + ++ V A +
Sbjct: 135 -LDREETPNHKLLVLASD 151
Score = 64.1 bits (149), Expect = 4e-09
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 233 SNQFLLETAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 289
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G + +V A D D G N + Y L D FS+D R+G LTV +
Sbjct: 290 FVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-- 347
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 348 LDREKEDKYLFTILAKD 364
Score = 62.5 bits (145), Expect = 1e-08
Identities = 44/156 (28%), Positives = 74/156 (47%), Gaps = 10/156 (6%)
Query: 1001 VIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+IV + L E + + + + DGG + ++V V D ND+ PVFK+T ++ E
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPE 80
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP---FEISPLTGVLSVNGELDRETE 1113
+ ++ ATDAD G+NA + + +++ F ++ TG++++ LDRE
Sbjct: 81 NAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREET 140
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
+ L V+A D G DVNDN P
Sbjct: 141 PNHKLLVLASDGG---LMPARAMVLVNVTDVNDNVP 173
Score = 59.7 bits (138), Expect = 8e-08
Identities = 50/178 (28%), Positives = 85/178 (47%), Gaps = 18/178 (10%)
Query: 218 IHAIDQDLGVGATLRYE---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
+HA D D+G A + + L+S R+LF L++ G + +++ LD + N + L
Sbjct: 91 LHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----L 145
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQV 328
V AS + L A+A V + + D+NDN+P ++ + N ++V EN+P + +
Sbjct: 146 LVLAS--DGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 203
Query: 329 MATDKDQGENGEFTYQLDDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TDKD NG T D + F + P S + LD E+ +K+ A +
Sbjct: 204 TVTDKDADHNGRVTC-FTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAAD 260
Score = 58.4 bits (135), Expect = 2e-07
Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 412 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 464
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V N S LP+ G V QV+A D D
Sbjct: 465 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDND 524
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 525 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 570
Score = 52.8 bits (121), Expect = 9e-06
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ PSN YE + S GTV+ +V AVD D G N V Y
Sbjct: 475 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 533
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 534 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 588
Query: 556 TIEV 559
+ V
Sbjct: 589 NLFV 592
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/206 (24%), Positives = 93/206 (45%), Gaps = 27/206 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSLTI 130
G+ +++ ++V V I D NDN P+F Y+ V E P G I + P G + +
Sbjct: 366 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 425
Query: 131 PL---------TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L T+ + + +FDR+K + + V D G + SS K
Sbjct: 426 TLSILDENDDFTIDSQTGVIRPNISFDREKQES-----YTFYVKAEDGGRVSRSSSAKVT 480
Query: 182 LLLRKVLD------YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
+ + V D + ++LV+ ++ ++F + A+D D G+ A +RY +
Sbjct: 481 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT---VVFQ--VIAVDNDTGMNAEVRYSI 535
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDL 261
+ GN R LF++D G++ L ++ D+
Sbjct: 536 VGGNTRDLFAIDQETGNITLMEKCDV 561
Score = 48.0 bits (109), Expect = 3e-04
Identities = 47/166 (28%), Positives = 71/166 (42%), Gaps = 12/166 (7%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEH--Y 1285
G P SSTAIL V+V D D + PVF E+ I EN + L+ T+
Sbjct: 45 GFPQRSSTAILQVSVTDTND-----NHPVFKETEIEVSIPENAPVGTSVTQLHATDADIG 99
Query: 1286 ENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
EN K+ + N RR F ++ G + + DRE ++++V A
Sbjct: 100 ENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARA 159
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAI 1391
++ V DV + + D++ +V VND + N PL T I
Sbjct: 160 MVLVNVT-DVNDNVPSIDIRYIV--NPVNDT--VVLSENIPLNTKI 200
Score = 37.9 bits (84), Expect = 0.28
Identities = 75/327 (22%), Positives = 126/327 (38%), Gaps = 63/327 (19%)
Query: 1102 LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWK 1161
L V ELDRE +D Y++ V D G D NDN
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVT-DTNDN-------------- 65
Query: 1162 HPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQR 1221
HP E + +I ENAP+GT+V ++ A D D IG N I +S
Sbjct: 66 HPVFKETE------------IEVSIPENAPVGTSVTQLHATDAD-IGE-NAKIHFSFSNL 111
Query: 1222 KNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL 1281
+ L L++T L +T+ + D E + + + L + + +V +N+
Sbjct: 112 VSNIARRLFHLNATTGL-ITIKEPLDREETPNHKLLV-----LASDGGLMPARAMVLVNV 165
Query: 1282 TEHYEN---FKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
T+ +N +RY + NDT + + P N + L+ D++ V + +
Sbjct: 166 TDVNDNVPSIDIRYIVNPVNDTVVLSENI--PLNTKIALITVTDKDADHNGRVTCFTDHE 223
Query: 1339 KYSRELP-----HMIYPVAEDVLEGMTKYDVKVV----------------VRIKDVNDNS 1377
R P ++ A E +Y +K++ +++KD NDN+
Sbjct: 224 IPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 283
Query: 1378 PKFTNGNRPLVTAIPTTAPFGYQVMQL 1404
P FT + +IP G Q+ ++
Sbjct: 284 PVFTQSF--VTVSIPENNSPGIQLTKV 308
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/114 (29%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS--LTIPLTVPRGLT 139
S T Y++ D + + VT++ + K +F++ P S L +P T P G
Sbjct: 458 SYTFYVK-AEDGGRVSRSSSAKVTINVVDVNDNKP-VFIVPPSNCSYELVLPSTNP-GTV 514
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 515 VFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 565
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
LT A D+D G NA I Y + + P F++D +G + VV L R+
Sbjct: 305 LTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 351
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 45 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 85
>AJ564933-1|CAD92412.1| 831|Homo sapiens protocadherin protein.
Length = 831
Score = 138 bits (333), Expect = 2e-31
Identities = 140/517 (27%), Positives = 223/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 31 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 83
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 84 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 143
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 144 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 197
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + +++ + + ++
Sbjct: 198 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 255
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ I T +S++
Sbjct: 256 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG----IQLTKVSAM 311
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ N + D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 312 DADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 370
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y ++ EN + GT +I TD D G N+
Sbjct: 371 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 426
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 427 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 484
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 485 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 521
Score = 97.9 bits (233), Expect = 2e-19
Identities = 81/246 (32%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G + K++A+D DSG N +I Y
Sbjct: 266 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYL 324
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 325 LGPDA--PPE------------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 370
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF YNF V E +G + TD D+G N+ +T I
Sbjct: 371 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 430
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 431 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 487
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 488 DNKPVF 493
Score = 90.2 bits (214), Expect = 5e-17
Identities = 124/488 (25%), Positives = 197/488 (40%), Gaps = 70/488 (14%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P+GT++ +L+A D D G N +I + F++ V S ++ +R F +N G
Sbjct: 78 IPENAPVGTSVTQLHATDADIGENAKIHFSFSNLV----SNIA------RRLFHLNATTG 127
Query: 1000 HVIVARSLPPES--EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTW----YNFN 1053
+ + L E +L + A DGG + V V V DVND+ P + N
Sbjct: 128 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 187
Query: 1054 V--EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGEL 1108
V E + + TD D N +T F +D ++PF + P+ +L L
Sbjct: 188 VVLSENIPLNTKIALITVTDKDADHNGRVTCF---TDHEIPFRLRPVFSNQFLLETAAYL 244
Query: 1109 DRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADEL 1168
D E+ +Y + ++A D G D NDN+P F + PE +
Sbjct: 245 DYESTKEYAIKLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPENNSP 301
Query: 1169 SNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL- 1227
+ M + N +G F+ D G ++ L + K + L
Sbjct: 302 GIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLD---CRTGMLTVVKKLDREKEDKYLF 358
Query: 1228 -------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVS 1278
G+P L+S + V++ D D + PVF Y + EN+ + V L++
Sbjct: 359 TILAKDNGVPPLTSNVTVFVSIIDQND-----NSPVFTHNEYNFYVPENLPRHGTVGLIT 413
Query: 1279 LNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
+ ++ +N + IL+END F ID + G + S DRE +++Y V+
Sbjct: 414 VTDPDYGDNSAVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK---- 464
Query: 1339 KYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAP 1396
AED KV + + DVNDN P F N +P+T P
Sbjct: 465 -------------AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP 511
Query: 1397 FGYQVMQL 1404
G V Q+
Sbjct: 512 -GTVVFQV 518
Score = 83.0 bits (196), Expect = 7e-15
Identities = 53/161 (32%), Positives = 85/161 (52%), Gaps = 9/161 (5%)
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
+ QK LDRE++D Y M V E + G + + + + D NDN PVF+ E I
Sbjct: 21 LIVQKELDREEKDTYVMKVKVE-DGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIP 79
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNA----LFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
EN+ +GT + + ATDAD G NA F + + +F ++ TG++ I + L
Sbjct: 80 ENAPVGTSVTQ---LHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLIT-IKEPL 135
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFN 894
DRE+ +KL ++A D G + + A +++ + D NDN P +
Sbjct: 136 DREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSID 176
Score = 77.4 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 308 VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE-----DKYLFTIL 361
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + YN + ENLP +V + TD D G+
Sbjct: 362 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 421
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 422 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 467
Score = 64.9 bits (151), Expect = 2e-09
Identities = 41/138 (29%), Positives = 74/138 (53%), Gaps = 12/138 (8%)
Query: 253 LFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN 312
L ++KELD + + +T+V++V+ P +++ A +++ + D NDN P F+
Sbjct: 21 LIVQKELDRE-----EKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIE 75
Query: 313 ISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQT 367
+SI EN P G SV Q+ ATD D GEN + + + + F ++ +G +T++
Sbjct: 76 VSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP- 134
Query: 368 VLDREAHSSLRMKVYAKE 385
LDRE + ++ V A +
Sbjct: 135 -LDREETPNHKLLVLASD 151
Score = 64.1 bits (149), Expect = 4e-09
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 233 SNQFLLETAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 289
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G + +V A D D G N + Y L D FS+D R+G LTV +
Sbjct: 290 FVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-- 347
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 348 LDREKEDKYLFTILAKD 364
Score = 62.5 bits (145), Expect = 1e-08
Identities = 44/156 (28%), Positives = 74/156 (47%), Gaps = 10/156 (6%)
Query: 1001 VIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+IV + L E + + + + DGG + ++V V D ND+ PVFK+T ++ E
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPE 80
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP---FEISPLTGVLSVNGELDRETE 1113
+ ++ ATDAD G+NA + + +++ F ++ TG++++ LDRE
Sbjct: 81 NAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREET 140
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
+ L V+A D G DVNDN P
Sbjct: 141 PNHKLLVLASDGG---LMPARAMVLVNVTDVNDNVP 173
Score = 59.7 bits (138), Expect = 8e-08
Identities = 50/178 (28%), Positives = 85/178 (47%), Gaps = 18/178 (10%)
Query: 218 IHAIDQDLGVGATLRYE---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
+HA D D+G A + + L+S R+LF L++ G + +++ LD + N + L
Sbjct: 91 LHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----L 145
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQV 328
V AS + L A+A V + + D+NDN+P ++ + N ++V EN+P + +
Sbjct: 146 LVLAS--DGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 203
Query: 329 MATDKDQGENGEFTYQLDDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TDKD NG T D + F + P S + LD E+ +K+ A +
Sbjct: 204 TVTDKDADHNGRVTC-FTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAAD 260
Score = 58.4 bits (135), Expect = 2e-07
Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 412 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 464
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V N S LP+ G V QV+A D D
Sbjct: 465 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDND 524
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 525 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 570
Score = 52.8 bits (121), Expect = 9e-06
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ PSN YE + S GTV+ +V AVD D G N V Y
Sbjct: 475 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 533
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 534 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 588
Query: 556 TIEV 559
+ V
Sbjct: 589 NLFV 592
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/206 (24%), Positives = 93/206 (45%), Gaps = 27/206 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSLTI 130
G+ +++ ++V V I D NDN P+F Y+ V E P G I + P G + +
Sbjct: 366 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 425
Query: 131 PL---------TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L T+ + + +FDR+K + + V D G + SS K
Sbjct: 426 TLSILDENDDFTIDSQTGVIRPNISFDREKQES-----YTFYVKAEDGGRVSRSSSAKVT 480
Query: 182 LLLRKVLD------YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
+ + V D + ++LV+ ++ ++F + A+D D G+ A +RY +
Sbjct: 481 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT---VVFQ--VIAVDNDTGMNAEVRYSI 535
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDL 261
+ GN R LF++D G++ L ++ D+
Sbjct: 536 VGGNTRDLFAIDQETGNITLMEKCDV 561
Score = 48.0 bits (109), Expect = 3e-04
Identities = 47/166 (28%), Positives = 71/166 (42%), Gaps = 12/166 (7%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEH--Y 1285
G P SSTAIL V+V D D + PVF E+ I EN + L+ T+
Sbjct: 45 GFPQRSSTAILQVSVTDTND-----NHPVFKETEIEVSIPENAPVGTSVTQLHATDADIG 99
Query: 1286 ENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
EN K+ + N RR F ++ G + + DRE ++++V A
Sbjct: 100 ENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARA 159
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAI 1391
++ V DV + + D++ +V VND + N PL T I
Sbjct: 160 MVLVNVT-DVNDNVPSIDIRYIV--NPVNDT--VVLSENIPLNTKI 200
Score = 37.9 bits (84), Expect = 0.28
Identities = 75/327 (22%), Positives = 126/327 (38%), Gaps = 63/327 (19%)
Query: 1102 LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWK 1161
L V ELDRE +D Y++ V D G D NDN
Sbjct: 21 LIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVT-DTNDN-------------- 65
Query: 1162 HPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQR 1221
HP E + +I ENAP+GT+V ++ A D D IG N I +S
Sbjct: 66 HPVFKETE------------IEVSIPENAPVGTSVTQLHATDAD-IGE-NAKIHFSFSNL 111
Query: 1222 KNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL 1281
+ L L++T L +T+ + D E + + + L + + +V +N+
Sbjct: 112 VSNIARRLFHLNATTGL-ITIKEPLDREETPNHKLLV-----LASDGGLMPARAMVLVNV 165
Query: 1282 TEHYEN---FKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
T+ +N +RY + NDT + + P N + L+ D++ V + +
Sbjct: 166 TDVNDNVPSIDIRYIVNPVNDTVVLSENI--PLNTKIALITVTDKDADHNGRVTCFTDHE 223
Query: 1339 KYSRELP-----HMIYPVAEDVLEGMTKYDVKVV----------------VRIKDVNDNS 1377
R P ++ A E +Y +K++ +++KD NDN+
Sbjct: 224 IPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 283
Query: 1378 PKFTNGNRPLVTAIPTTAPFGYQVMQL 1404
P FT + +IP G Q+ ++
Sbjct: 284 PVFTQSF--VTVSIPENNSPGIQLTKV 308
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/114 (29%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS--LTIPLTVPRGLT 139
S T Y++ D + + VT++ + K +F++ P S L +P T P G
Sbjct: 458 SYTFYVK-AEDGGRVSRSSSAKVTINVVDVNDNKP-VFIVPPSNCSYELVLPSTNP-GTV 514
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 515 VFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 565
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
LT A D+D G NA I Y + + P F++D +G + VV L R+
Sbjct: 305 LTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 351
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 45 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 85
>AJ276804-1|CAC13123.1| 1025|Homo sapiens protocadherin protein.
Length = 1025
Score = 138 bits (333), Expect = 2e-31
Identities = 140/517 (27%), Positives = 223/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 211 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 263
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 264 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 324 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + +++ + + ++
Sbjct: 378 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ I T +S++
Sbjct: 436 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG----IQLTKVSAM 491
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ N + D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 550
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y ++ EN + GT +I TD D G N+
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 606
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 607 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701
Score = 113 bits (273), Expect = 3e-24
Identities = 116/473 (24%), Positives = 203/473 (42%), Gaps = 23/473 (4%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+++ V + + D NDN P+F P+ + S+ N+ + + AVDPD+G NG+
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLF-PATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 497 YDLQRTSNLTITSPFKINPNTGTVS--VAESPILEGRHALFVEASDQPANPSERRYSLAV 554
Y+L ++ N+ + P + + + + +V +R S A+
Sbjct: 176 YELIKSQNIFGLDVIE-TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 234
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQN---DVSYDL 610
+ + VT T N P F E + N +GTSV Q+ DA +N S+
Sbjct: 235 LQVSVT-DTNDNH---PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN 290
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L F + +G+IT+ + L R P + +A + + V+V DVN
Sbjct: 291 LVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDGGLMPARAMVLVNVTDVN 349
Query: 671 DE-RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D + ++ +P+ V + +I ++ + G V ++
Sbjct: 350 DNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVI-AEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ + T LD E Y + ++ A+ K ++ + + + I ++DENDN PVF
Sbjct: 410 PVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKDENDNAPVFT 467
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ I EN+ G ++ + A DAD G NA Y L + F +D TG++
Sbjct: 468 QSFVTVSIPENNSPGIQLTK---VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTV 524
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
+ LDREK+ Y +++A+D G L+S + + I D+NDN P F E N
Sbjct: 525 V-KKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Score = 97.9 bits (233), Expect = 2e-19
Identities = 81/246 (32%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G + K++A+D DSG N +I Y
Sbjct: 446 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYL 504
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 505 LGPDA--PPE------------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF YNF V E +G + TD D+G N+ +T I
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 610
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 611 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 667
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 668 DNKPVF 673
Score = 77.8 bits (183), Expect = 3e-13
Identities = 157/658 (23%), Positives = 255/658 (38%), Gaps = 104/658 (15%)
Query: 770 IYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL 829
+ ++ IED NDN P+F I ENS I ++ + A D D G N + Y L
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLP---AAVDPDVGINGVQNYEL 178
Query: 830 FGE----GKEMFDVDENTGVVKFI-GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIM 882
G ++ + E + + I LDRE+K Y + + D G SS A L +
Sbjct: 179 IKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238
Query: 883 IGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPE 942
+ D NDN P F + E I N G ++ ++ A D D I E
Sbjct: 239 VTDTNDNHPVFKETE------IEVSIPENAPVGTSVTQL-----HATDAD-------IGE 280
Query: 943 NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRY-FVINERHGHV 1001
N I + +L S + ++ + N+ + K D E + ++ G +
Sbjct: 281 NAK-----IHFSFSNLVSNIARRL-FHLNATTGLITIKEPLDREETPNHKLLVLASDGGL 334
Query: 1002 IVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTR 1061
+ AR++ + ++ D + +I +R V VND + + N T+
Sbjct: 335 MPARAM-------VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN--------TK 379
Query: 1062 RVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETEDKYIL 1118
L V DAD N +T F +D ++PF + P+ +L LD E+ +Y +
Sbjct: 380 IALITVTDKDAD--HNGRVTCF---TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAI 434
Query: 1119 TVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMM 1178
++A D G D NDN+P F + PE + + M
Sbjct: 435 KLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPENNSPGIQLTKVSAM 491
Query: 1179 IPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL--------GLP 1230
+ N +G F+ D G ++ L + K + L G+P
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLD---CRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 548
Query: 1231 SLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEHYENF 1288
L+S + V++ D D + PVF Y + EN+ + V L+++ ++ +N
Sbjct: 549 PLTSNVTVFVSIIDQND-----NSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ IL+END F ID + G + S DRE +++Y V+
Sbjct: 604 AVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK-------------- 644
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAPFGYQVMQL 1404
AED KV + + DVNDN P F N +P+T P G V Q+
Sbjct: 645 ---AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQV 698
Score = 77.4 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 488 VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE-----DKYLFTIL 541
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + YN + ENLP +V + TD D G+
Sbjct: 542 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 601
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 602 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 647
Score = 76.2 bits (179), Expect = 9e-13
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 21/178 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A+D D+G+ YELI + +F LD + L ++KELD + + +T+
Sbjct: 163 AVDPDVGINGVQNYELIKSQN--IFGLDVIETPEGDKMPQLIVQKELDRE-----EKDTY 215
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V++V+ P +++ A +++ + D NDN P F+ +SI EN P G SV Q+ ATD
Sbjct: 216 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 275
Query: 333 KDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D GEN + + + + F ++ +G +T++ LDRE + ++ V A +
Sbjct: 276 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP--LDREETPNHKLLVLASD 331
Score = 67.7 bits (158), Expect = 3e-10
Identities = 82/341 (24%), Positives = 143/341 (41%), Gaps = 47/341 (13%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTV 134
++I + + IED+NDN P+F T ++++ E + K L A + P + I
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK--YTLPAAVDPDVGI--NG 172
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR-KVLDYDAG 193
+ + K F D TP D ++ + L+ K +++ KV D
Sbjct: 173 VQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE-----LDREEKDTYVMKVKVEDGGFP 227
Query: 194 DKEFQLVIMASG----------KRIHKEILFPE---------PIHAIDQDLGVGATLRYE 234
+ ++ S K E+ PE +HA D D+G A + +
Sbjct: 228 QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFS 287
Query: 235 ---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQAR 291
L+S R+LF L++ G + +++ LD + N + L V AS + L A+A
Sbjct: 288 FSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----LLVLAS--DGGLMPARAM 340
Query: 292 VEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN+P ++ + N ++V EN+P + + TDKD NG T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-F 399
Query: 346 DDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D + F + P S + LD E+ +K+ A +
Sbjct: 400 TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAAD 440
Score = 64.1 bits (149), Expect = 4e-09
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 413 SNQFLLETAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 469
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G + +V A D D G N + Y L D FS+D R+G LTV +
Sbjct: 470 FVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-- 527
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 528 LDREKEDKYLFTILAKD 544
Score = 63.3 bits (147), Expect = 6e-09
Identities = 103/485 (21%), Positives = 185/485 (38%), Gaps = 50/485 (10%)
Query: 940 IPENIPIGTTIIKLN-ALDLDSGLNGQIRYEFNSEVY-IPPSKLSADALEVKRYFVINER 997
+PEN+ IG + LN +L + L ++++ + +P ++ D E+ F R
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEI---FTTGAR 90
Query: 998 HGHVIVARSLPPESEFRLNIS-ALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ +P + + A+ + + +R ++D+ND+ P+F T N ++ E
Sbjct: 91 IDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPE 150
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGELDRE 1111
A D D G N Y + S ++ L V ELDRE
Sbjct: 151 NSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE 210
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
+D Y++ V D G D NDN P F + +E PE +
Sbjct: 211 EKDTYVMKVKVEDGG-FPQRSSTAILQVSVTDTNDNHPVFKETE--IEVSIPENAPVGT- 266
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLP----QRKNQ 1224
SV + A I ENA I + + + +N + + N GLI P + N
Sbjct: 267 ---SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 1225 QNLGLPS----LSSTAILMVTVADVPDEVEMSDKPVFISRYYE-LEIEENVNAPVELVSL 1279
+ L L S + + A+++V V DV D V D ++ + + + EN+ ++ +
Sbjct: 324 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 383
Query: 1280 NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQK 1339
+T+ + R +++ R R V ++ A
Sbjct: 384 TVTDKDADHNGRVTCFTDHEIPFRL------------------RPVFSNQFLLETAAYLD 425
Query: 1340 YSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGY 1399
Y + I +A D + + +++KD NDN+P FT + +IP G
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF--VTVSIPENNSPGI 483
Query: 1400 QVMQL 1404
Q+ ++
Sbjct: 484 QLTKV 488
Score = 58.4 bits (135), Expect = 2e-07
Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 644
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V N S LP+ G V QV+A D D
Sbjct: 645 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDND 704
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 705 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 750
Score = 52.8 bits (121), Expect = 9e-06
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ PSN YE + S GTV+ +V AVD D G N V Y
Sbjct: 655 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 714 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 768
Query: 556 TIEV 559
+ V
Sbjct: 769 NLFV 772
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/206 (24%), Positives = 93/206 (45%), Gaps = 27/206 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSLTI 130
G+ +++ ++V V I D NDN P+F Y+ V E P G I + P G + +
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 605
Query: 131 PL---------TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L T+ + + +FDR+K + + V D G + SS K
Sbjct: 606 TLSILDENDDFTIDSQTGVIRPNISFDREKQES-----YTFYVKAEDGGRVSRSSSAKVT 660
Query: 182 LLLRKVLD------YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
+ + V D + ++LV+ ++ ++F + A+D D G+ A +RY +
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT---VVFQ--VIAVDNDTGMNAEVRYSI 715
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDL 261
+ GN R LF++D G++ L ++ D+
Sbjct: 716 VGGNTRDLFAIDQETGNITLMEKCDV 741
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/114 (29%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS--LTIPLTVPRGLT 139
S T Y++ D + + VT++ + K +F++ P S L +P T P G
Sbjct: 638 SYTFYVK-AEDGGRVSRSSSAKVTINVVDVNDNKP-VFIVPPSNCSYELVLPSTNP-GTV 694
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 695 VFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 745
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
LT A D+D G NA I Y + + P F++D +G + VV L R+
Sbjct: 485 LTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 225 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 265
>AJ276803-1|CAC13122.1| 1037|Homo sapiens protocadherin protein.
Length = 1037
Score = 138 bits (333), Expect = 2e-31
Identities = 138/517 (26%), Positives = 224/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 232 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 284
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 285 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 344
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 345 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 398
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + ++++ + + ++
Sbjct: 399 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLENAAYLDYESTKEYAIK 456
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ Q+ + +
Sbjct: 457 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI--QLMKVSATDA 514
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ +L+ D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 515 DSGPNAEINYLLG--PDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 571
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y+ ++ EN + GT +I TD D G N+
Sbjct: 572 TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 627
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 628 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 685
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 686 DVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAV 722
Score = 116 bits (278), Expect = 9e-25
Identities = 124/424 (29%), Positives = 193/424 (45%), Gaps = 50/424 (11%)
Query: 931 VDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKR 990
V+ + ++ ENIP+ T I + D D+ NG++ + E+ P +L
Sbjct: 382 VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI---PFRLRP---VFSN 435
Query: 991 YFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK 1046
F++ A L ES E+ + + A D G LN + + + VKD ND+ PVF
Sbjct: 436 QFLLEN-------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFT 488
Query: 1047 KTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
+++ ++ E L KV ATDAD G NA + Y + P D F + TG+L+V
Sbjct: 489 QSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGP-DAPPEFSLDRRTGMLTVVK 547
Query: 1107 ELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEAD 1166
+LDRE EDKY+ T++A+DNG D NDNSP F E+K +
Sbjct: 548 KLDREKEDKYLFTILAKDNG-VPPLTSNVTVFVSIIDQNDNSPVF----THNEYKFYVPE 602
Query: 1167 ELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLP-QRKNQQ 1225
L H +V +I V +N+ + T++ + ND I + G+I ++ R+ Q+
Sbjct: 603 NLPRHG--TVGLITVTDPDYGDNSAV--TLSILDENDDFTIDSQTGVIRPNISFDREKQE 658
Query: 1226 NL---------GLPSLSSTAILMVTVADVPDEVEMSDKPVFI----SRYYELEI-EENVN 1271
+ G S SS+A + + V DV D +KPVFI + YEL + N
Sbjct: 659 SYTFYVKAEDGGRVSRSSSAKVTINVVDVND-----NKPVFIVPPYNYSYELVLPSTNPG 713
Query: 1272 APVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEV 1331
V V + N ++RY I+ N D+ F ID G + L+ D + V
Sbjct: 714 TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRV 770
Query: 1332 IVRA 1335
+V+A
Sbjct: 771 LVKA 774
Score = 115 bits (276), Expect = 2e-24
Identities = 119/493 (24%), Positives = 209/493 (42%), Gaps = 25/493 (5%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+++ V + + D NDN P+F P+ + S+ N+ + + AVDPD+G NG+
Sbjct: 138 DEIFRLVKIRFLIEDINDNAPLF-PATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 196
Query: 497 YDLQRTSNLTITSPFKINPNTGTVS--VAESPILEGRHALFVEASDQPANPSERRYSLAV 554
Y+L ++ N+ + P + + + + +V +R S A+
Sbjct: 197 YELIKSQNIFGLDVIE-TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 255
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQN---DVSYDL 610
+ + VT T N P F E + N +GTSV Q+ DA +N S+
Sbjct: 256 LQVSVT-DTNDNH---PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN 311
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L F + +G+IT+ + L R P + +A + + V+V DVN
Sbjct: 312 LVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDGGLMPARAMVLVNVTDVN 370
Query: 671 DE-RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D + ++ +P+ V + +I ++ + G V ++
Sbjct: 371 DNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 430
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVI-AEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ + LD E Y + ++ A+ K ++ + + + I ++DENDN PVF
Sbjct: 431 PVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKDENDNAPVFT 488
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ I EN+ G ++ + ATDAD G NA Y L + F +D TG++
Sbjct: 489 QSFVTVSIPENNSPGIQLMK---VSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTV 545
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHR 906
+ LDREK+ Y +++A+D G L+S + + I D+NDN P F E K +
Sbjct: 546 V-KKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNE--YKFYVPE 602
Query: 907 ETKLNGTAGFTII 919
+GT G +
Sbjct: 603 NLPRHGTVGLITV 615
Score = 97.1 bits (231), Expect = 4e-19
Identities = 80/246 (32%), Positives = 107/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G ++K++A D DSG N +I Y
Sbjct: 467 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYL 525
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 526 LGPDA--PPE------------FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 571
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF Y F V E +G + TD D+G N+ +T I
Sbjct: 572 TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 631
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 632 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 688
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 689 DNKPVF 694
Score = 89.4 bits (212), Expect = 9e-17
Identities = 117/467 (25%), Positives = 195/467 (41%), Gaps = 66/467 (14%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN I + A+D D G+NG YE I D +E ++
Sbjct: 169 IPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNI----FGLDVIETPE----GDKMP 220
Query: 1000 HVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+IV + L E + + + + DGG + ++V V D ND+ PVFK+T ++
Sbjct: 221 QLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIP 280
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP---FEISPLTGVLSVNGELDRET 1112
E + ++ ATDAD G+NA + + +++ F ++ TG++++ LDRE
Sbjct: 281 ENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREE 340
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE-LSNH 1171
+ L V+A D G DVNDN P ++ +P D + +
Sbjct: 341 TPNHKLLVLASDGG---LMPARAMVLVNVTDVNDNVPSI----DIRYIVNPVNDTVVLSE 393
Query: 1172 NF---ESVMMIPVYKATIEENA--------PIGTTVAKVFANDTDFIGNGNGLILYSLPQ 1220
N + +I V + N I + VF+N + N L S +
Sbjct: 394 NIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQF-LLENAAYLDYESTKE 452
Query: 1221 ---RKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELV 1277
+ + G P L+ +A+L + V D E + PVF + + I EN + ++L+
Sbjct: 453 YAIKLLAADAGKPPLNQSAMLFIKVKD-----ENDNAPVFTQSFVTVSIPENNSPGIQLM 507
Query: 1278 SLNLT--EHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
++ T + N ++ Y + D F +D R G L +V+ DRE +D Y + A
Sbjct: 508 KVSATDADSGPNAEINYLL----GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILA 563
Query: 1336 ERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTN 1382
+ + + P+ +V V V I D NDNSP FT+
Sbjct: 564 K--------DNGVPPLTS---------NVTVFVSIIDQNDNSPVFTH 593
Score = 77.0 bits (181), Expect = 5e-13
Identities = 161/662 (24%), Positives = 259/662 (39%), Gaps = 112/662 (16%)
Query: 770 IYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL 829
+ ++ IED NDN P+F I ENS I ++ + A D D G N + Y L
Sbjct: 143 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLP---AAVDPDVGINGVQNYEL 199
Query: 830 FGE----GKEMFDVDENTGVVKFI-GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIM 882
G ++ + E + + I LDRE+K Y + + D G SS A L +
Sbjct: 200 IKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 259
Query: 883 IGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPE 942
+ D NDN P F + E I N G ++ ++ A D D I E
Sbjct: 260 VTDTNDNHPVFKETE------IEVSIPENAPVGTSVTQL-----HATDAD-------IGE 301
Query: 943 NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRY-FVINERHGHV 1001
N I + +L S + ++ + N+ + K D E + ++ G +
Sbjct: 302 NAK-----IHFSFSNLVSNIARRL-FHLNATTGLITIKEPLDREETPNHKLLVLASDGGL 355
Query: 1002 IVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTR 1061
+ AR++ + ++ D + +I +R V VND + + N T+
Sbjct: 356 MPARAM-------VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN--------TK 400
Query: 1062 RVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETEDKYIL 1118
L V DAD N +T F +D ++PF + P+ +L LD E+ +Y +
Sbjct: 401 IALITVTDKDAD--HNGRVTCF---TDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAI 455
Query: 1119 TVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMM 1178
++A D G D NDN+P F + PE +N +M
Sbjct: 456 KLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPE----NNSPGIQLMK 508
Query: 1179 IPVYKATIEENAPI----GTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL------- 1227
+ A NA I G F+ D G ++ L + K + L
Sbjct: 509 VSATDADSGPNAEINYLLGPDAPPEFSLDR---RTGMLTVVKKLDREKEDKYLFTILAKD 565
Query: 1228 -GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEH 1284
G+P L+S + V++ D D + PVF Y+ + EN+ + V L+++ ++
Sbjct: 566 NGVPPLTSNVTVFVSIIDQND-----NSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDY 620
Query: 1285 YENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSREL 1344
+N + IL+END F ID + G + S DRE +++Y V+
Sbjct: 621 GDNSAVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK---------- 665
Query: 1345 PHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAPFGYQVM 1402
AED KV + + DVNDN P F N +P+T P G V
Sbjct: 666 -------AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNP-GTVVF 717
Query: 1403 QL 1404
Q+
Sbjct: 718 QV 719
Score = 76.2 bits (179), Expect = 9e-13
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 21/178 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A+D D+G+ YELI + +F LD + L ++KELD + + +T+
Sbjct: 184 AVDPDVGINGVQNYELIKSQN--IFGLDVIETPEGDKMPQLIVQKELDRE-----EKDTY 236
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V++V+ P +++ A +++ + D NDN P F+ +SI EN P G SV Q+ ATD
Sbjct: 237 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 296
Query: 333 KDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D GEN + + + + F ++ +G +T++ LDRE + ++ V A +
Sbjct: 297 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP--LDREETPNHKLLVLASD 352
Score = 74.1 bits (174), Expect = 3e-12
Identities = 51/168 (30%), Positives = 78/168 (46%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 509 VSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKE-----DKYLFTIL 562
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + Y + ENLP +V + TD D G+
Sbjct: 563 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGD 622
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 623 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 668
Score = 70.1 bits (164), Expect = 6e-11
Identities = 83/341 (24%), Positives = 144/341 (42%), Gaps = 47/341 (13%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTV 134
++I + + IED+NDN P+F T ++++ E + K L A + P + I
Sbjct: 138 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK--YTLPAAVDPDVGI--NG 193
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR-KVLDYDAG 193
+ + K F D TP D ++ + L+ K +++ KV D
Sbjct: 194 VQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE-----LDREEKDTYVMKVKVEDGGFP 248
Query: 194 DKEFQLVIMASG----------KRIHKEILFPE---------PIHAIDQDLGVGATLRYE 234
+ ++ S K E+ PE +HA D D+G A + +
Sbjct: 249 QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFS 308
Query: 235 ---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQAR 291
L+S R+LF L++ G + +++ LD + N + L V AS + L A+A
Sbjct: 309 FSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----LLVLAS--DGGLMPARAM 361
Query: 292 VEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN+P ++ + N ++V EN+P + + TDKD NG T
Sbjct: 362 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-F 420
Query: 346 DDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D + F + P S + N LD E+ +K+ A +
Sbjct: 421 TDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAAD 461
Score = 70.1 bits (164), Expect = 6e-11
Identities = 46/137 (33%), Positives = 65/137 (47%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 434 SNQFLLENAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 490
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G +++V ATD D G N E Y L D FS+D R+G LTV +
Sbjct: 491 FVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKK-- 548
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 549 LDREKEDKYLFTILAKD 565
Score = 67.7 bits (158), Expect = 3e-10
Identities = 105/485 (21%), Positives = 186/485 (38%), Gaps = 50/485 (10%)
Query: 940 IPENIPIGTTIIKLN-ALDLDSGLNGQIRYEFNSEVY-IPPSKLSADALEVKRYFVINER 997
IPEN+ IG + LN +L + L ++++ + +P ++ D E+ F R
Sbjct: 55 IPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEI---FTTGAR 111
Query: 998 HGHVIVARSLPPESEFRLNIS-ALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ +P + + A+ + + +R ++D+ND+ P+F T N ++ E
Sbjct: 112 IDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPE 171
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGELDRE 1111
A D D G N Y + S ++ L V ELDRE
Sbjct: 172 NSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE 231
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
+D Y++ V D G D NDN P F + +E PE +
Sbjct: 232 EKDTYVMKVKVEDGG-FPQRSSTAILQVSVTDTNDNHPVFKETE--IEVSIPENAPVGT- 287
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLP----QRKNQ 1224
SV + A I ENA I + + + +N + + N GLI P + N
Sbjct: 288 ---SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 344
Query: 1225 QNLGLPS----LSSTAILMVTVADVPDEVEMSDKPVFISRYYE-LEIEENVNAPVELVSL 1279
+ L L S + + A+++V V DV D V D ++ + + + EN+ ++ +
Sbjct: 345 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 404
Query: 1280 NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQK 1339
+T+ + R +++ R R V ++ A
Sbjct: 405 TVTDKDADHNGRVTCFTDHEIPFRL------------------RPVFSNQFLLENAAYLD 446
Query: 1340 YSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGY 1399
Y + I +A D + + +++KD NDN+P FT + +IP G
Sbjct: 447 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF--VTVSIPENNSPGI 504
Query: 1400 QVMQL 1404
Q+M++
Sbjct: 505 QLMKV 509
Score = 62.1 bits (144), Expect = 1e-08
Identities = 49/166 (29%), Positives = 78/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 613 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 665
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V YN S LP+ G V QV+A D D
Sbjct: 666 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDND 725
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 726 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 771
Score = 50.4 bits (115), Expect = 5e-05
Identities = 39/124 (31%), Positives = 62/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ P N YE + S GTV+ +V AVD D G N V Y
Sbjct: 676 SSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 734
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 735 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 789
Query: 556 TIEV 559
+ V
Sbjct: 790 NLFV 793
Score = 40.7 bits (91), Expect = 0.039
Identities = 36/116 (31%), Positives = 53/116 (45%), Gaps = 24/116 (20%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRG 137
S+ VT+ + DVNDN P+F+ PY+ + + L +P T P G
Sbjct: 675 SSSAKVTINVVDVNDNKPVFIVPPYNYSYE--------------------LVLPSTNP-G 713
Query: 138 LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 714 TVVFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 766
Score = 35.9 bits (79), Expect = 1.1
Identities = 18/47 (38%), Positives = 27/47 (57%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
L ATD+D G NA+I Y + + P F++D +G + VV L R+
Sbjct: 506 LMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 552
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 246 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 286
>AF332219-1|AAK13471.1| 1337|Homo sapiens protocadherin 11 protein.
Length = 1337
Score = 138 bits (333), Expect = 2e-31
Identities = 140/517 (27%), Positives = 223/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 211 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 263
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 264 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 324 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + +++ + + ++
Sbjct: 378 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ I T +S++
Sbjct: 436 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG----IQLTKVSAM 491
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ N + D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 550
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y ++ EN + GT +I TD D G N+
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 606
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 607 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701
Score = 113 bits (273), Expect = 3e-24
Identities = 116/473 (24%), Positives = 203/473 (42%), Gaps = 23/473 (4%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+++ V + + D NDN P+F P+ + S+ N+ + + AVDPD+G NG+
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLF-PATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 497 YDLQRTSNLTITSPFKINPNTGTVS--VAESPILEGRHALFVEASDQPANPSERRYSLAV 554
Y+L ++ N+ + P + + + + +V +R S A+
Sbjct: 176 YELIKSQNIFGLDVIE-TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 234
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQN---DVSYDL 610
+ + VT T N P F E + N +GTSV Q+ DA +N S+
Sbjct: 235 LQVSVT-DTNDNH---PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN 290
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L F + +G+IT+ + L R P + +A + + V+V DVN
Sbjct: 291 LVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDGGLMPARAMVLVNVTDVN 349
Query: 671 DE-RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D + ++ +P+ V + +I ++ + G V ++
Sbjct: 350 DNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVI-AEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ + T LD E Y + ++ A+ K ++ + + + I ++DENDN PVF
Sbjct: 410 PVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKDENDNAPVFT 467
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ I EN+ G ++ + A DAD G NA Y L + F +D TG++
Sbjct: 468 QSFVTVSIPENNSPGIQLTK---VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTV 524
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
+ LDREK+ Y +++A+D G L+S + + I D+NDN P F E N
Sbjct: 525 V-KKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Score = 97.9 bits (233), Expect = 2e-19
Identities = 81/246 (32%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G + K++A+D DSG N +I Y
Sbjct: 446 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYL 504
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 505 LGPDA--PPE------------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF YNF V E +G + TD D+G N+ +T I
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 610
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 611 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 667
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 668 DNKPVF 673
Score = 77.8 bits (183), Expect = 3e-13
Identities = 157/658 (23%), Positives = 255/658 (38%), Gaps = 104/658 (15%)
Query: 770 IYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL 829
+ ++ IED NDN P+F I ENS I ++ + A D D G N + Y L
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLP---AAVDPDVGINGVQNYEL 178
Query: 830 FGE----GKEMFDVDENTGVVKFI-GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIM 882
G ++ + E + + I LDRE+K Y + + D G SS A L +
Sbjct: 179 IKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238
Query: 883 IGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPE 942
+ D NDN P F + E I N G ++ ++ A D D I E
Sbjct: 239 VTDTNDNHPVFKETE------IEVSIPENAPVGTSVTQL-----HATDAD-------IGE 280
Query: 943 NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRY-FVINERHGHV 1001
N I + +L S + ++ + N+ + K D E + ++ G +
Sbjct: 281 NAK-----IHFSFSNLVSNIARRL-FHLNATTGLITIKEPLDREETPNHKLLVLASDGGL 334
Query: 1002 IVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTR 1061
+ AR++ + ++ D + +I +R V VND + + N T+
Sbjct: 335 MPARAM-------VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN--------TK 379
Query: 1062 RVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETEDKYIL 1118
L V DAD N +T F +D ++PF + P+ +L LD E+ +Y +
Sbjct: 380 IALITVTDKDAD--HNGRVTCF---TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAI 434
Query: 1119 TVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMM 1178
++A D G D NDN+P F + PE + + M
Sbjct: 435 KLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPENNSPGIQLTKVSAM 491
Query: 1179 IPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL--------GLP 1230
+ N +G F+ D G ++ L + K + L G+P
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLD---CRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 548
Query: 1231 SLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEHYENF 1288
L+S + V++ D D + PVF Y + EN+ + V L+++ ++ +N
Sbjct: 549 PLTSNVTVFVSIIDQND-----NSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ IL+END F ID + G + S DRE +++Y V+
Sbjct: 604 AVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK-------------- 644
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAPFGYQVMQL 1404
AED KV + + DVNDN P F N +P+T P G V Q+
Sbjct: 645 ---AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQV 698
Score = 77.4 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 488 VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE-----DKYLFTIL 541
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + YN + ENLP +V + TD D G+
Sbjct: 542 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 601
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 602 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 647
Score = 76.2 bits (179), Expect = 9e-13
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 21/178 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A+D D+G+ YELI + +F LD + L ++KELD + + +T+
Sbjct: 163 AVDPDVGINGVQNYELIKSQN--IFGLDVIETPEGDKMPQLIVQKELDRE-----EKDTY 215
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V++V+ P +++ A +++ + D NDN P F+ +SI EN P G SV Q+ ATD
Sbjct: 216 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 275
Query: 333 KDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D GEN + + + + F ++ +G +T++ LDRE + ++ V A +
Sbjct: 276 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP--LDREETPNHKLLVLASD 331
Score = 67.7 bits (158), Expect = 3e-10
Identities = 82/341 (24%), Positives = 143/341 (41%), Gaps = 47/341 (13%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTV 134
++I + + IED+NDN P+F T ++++ E + K L A + P + I
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK--YTLPAAVDPDVGI--NG 172
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR-KVLDYDAG 193
+ + K F D TP D ++ + L+ K +++ KV D
Sbjct: 173 VQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE-----LDREEKDTYVMKVKVEDGGFP 227
Query: 194 DKEFQLVIMASG----------KRIHKEILFPE---------PIHAIDQDLGVGATLRYE 234
+ ++ S K E+ PE +HA D D+G A + +
Sbjct: 228 QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFS 287
Query: 235 ---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQAR 291
L+S R+LF L++ G + +++ LD + N + L V AS + L A+A
Sbjct: 288 FSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----LLVLAS--DGGLMPARAM 340
Query: 292 VEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN+P ++ + N ++V EN+P + + TDKD NG T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-F 399
Query: 346 DDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D + F + P S + LD E+ +K+ A +
Sbjct: 400 TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAAD 440
Score = 64.1 bits (149), Expect = 4e-09
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 413 SNQFLLETAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 469
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G + +V A D D G N + Y L D FS+D R+G LTV +
Sbjct: 470 FVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-- 527
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 528 LDREKEDKYLFTILAKD 544
Score = 63.3 bits (147), Expect = 6e-09
Identities = 103/485 (21%), Positives = 185/485 (38%), Gaps = 50/485 (10%)
Query: 940 IPENIPIGTTIIKLN-ALDLDSGLNGQIRYEFNSEVY-IPPSKLSADALEVKRYFVINER 997
+PEN+ IG + LN +L + L ++++ + +P ++ D E+ F R
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEI---FTTGAR 90
Query: 998 HGHVIVARSLPPESEFRLNIS-ALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ +P + + A+ + + +R ++D+ND+ P+F T N ++ E
Sbjct: 91 IDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPE 150
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGELDRE 1111
A D D G N Y + S ++ L V ELDRE
Sbjct: 151 NSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE 210
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
+D Y++ V D G D NDN P F + +E PE +
Sbjct: 211 EKDTYVMKVKVEDGG-FPQRSSTAILQVSVTDTNDNHPVFKETE--IEVSIPENAPVGT- 266
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLP----QRKNQ 1224
SV + A I ENA I + + + +N + + N GLI P + N
Sbjct: 267 ---SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 1225 QNLGLPS----LSSTAILMVTVADVPDEVEMSDKPVFISRYYE-LEIEENVNAPVELVSL 1279
+ L L S + + A+++V V DV D V D ++ + + + EN+ ++ +
Sbjct: 324 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 383
Query: 1280 NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQK 1339
+T+ + R +++ R R V ++ A
Sbjct: 384 TVTDKDADHNGRVTCFTDHEIPFRL------------------RPVFSNQFLLETAAYLD 425
Query: 1340 YSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGY 1399
Y + I +A D + + +++KD NDN+P FT + +IP G
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF--VTVSIPENNSPGI 483
Query: 1400 QVMQL 1404
Q+ ++
Sbjct: 484 QLTKV 488
Score = 58.4 bits (135), Expect = 2e-07
Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 644
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V N S LP+ G V QV+A D D
Sbjct: 645 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDND 704
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 705 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 750
Score = 52.8 bits (121), Expect = 9e-06
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ PSN YE + S GTV+ +V AVD D G N V Y
Sbjct: 655 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 714 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 768
Query: 556 TIEV 559
+ V
Sbjct: 769 NLFV 772
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/206 (24%), Positives = 93/206 (45%), Gaps = 27/206 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSLTI 130
G+ +++ ++V V I D NDN P+F Y+ V E P G I + P G + +
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 605
Query: 131 PL---------TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L T+ + + +FDR+K + + V D G + SS K
Sbjct: 606 TLSILDENDDFTIDSQTGVIRPNISFDREKQES-----YTFYVKAEDGGRVSRSSSAKVT 660
Query: 182 LLLRKVLD------YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
+ + V D + ++LV+ ++ ++F + A+D D G+ A +RY +
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT---VVFQ--VIAVDNDTGMNAEVRYSI 715
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDL 261
+ GN R LF++D G++ L ++ D+
Sbjct: 716 VGGNTRDLFAIDQETGNITLMEKCDV 741
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/114 (29%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS--LTIPLTVPRGLT 139
S T Y++ D + + VT++ + K +F++ P S L +P T P G
Sbjct: 638 SYTFYVK-AEDGGRVSRSSSAKVTINVVDVNDNKP-VFIVPPSNCSYELVLPSTNP-GTV 694
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 695 VFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 745
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
LT A D+D G NA I Y + + P F++D +G + VV L R+
Sbjct: 485 LTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 225 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 265
>AF332218-1|AAK13470.1| 1347|Homo sapiens protocadherin 11 protein.
Length = 1347
Score = 138 bits (333), Expect = 2e-31
Identities = 140/517 (27%), Positives = 223/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 211 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 263
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 264 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 324 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + +++ + + ++
Sbjct: 378 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ I T +S++
Sbjct: 436 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG----IQLTKVSAM 491
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ N + D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 550
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y ++ EN + GT +I TD D G N+
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 606
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 607 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701
Score = 113 bits (273), Expect = 3e-24
Identities = 116/473 (24%), Positives = 203/473 (42%), Gaps = 23/473 (4%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+++ V + + D NDN P+F P+ + S+ N+ + + AVDPD+G NG+
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLF-PATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 497 YDLQRTSNLTITSPFKINPNTGTVS--VAESPILEGRHALFVEASDQPANPSERRYSLAV 554
Y+L ++ N+ + P + + + + +V +R S A+
Sbjct: 176 YELIKSQNIFGLDVIE-TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 234
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQN---DVSYDL 610
+ + VT T N P F E + N +GTSV Q+ DA +N S+
Sbjct: 235 LQVSVT-DTNDNH---PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN 290
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L F + +G+IT+ + L R P + +A + + V+V DVN
Sbjct: 291 LVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDGGLMPARAMVLVNVTDVN 349
Query: 671 DE-RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D + ++ +P+ V + +I ++ + G V ++
Sbjct: 350 DNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVI-AEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ + T LD E Y + ++ A+ K ++ + + + I ++DENDN PVF
Sbjct: 410 PVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKDENDNAPVFT 467
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ I EN+ G ++ + A DAD G NA Y L + F +D TG++
Sbjct: 468 QSFVTVSIPENNSPGIQLTK---VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTV 524
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
+ LDREK+ Y +++A+D G L+S + + I D+NDN P F E N
Sbjct: 525 V-KKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Score = 97.9 bits (233), Expect = 2e-19
Identities = 81/246 (32%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G + K++A+D DSG N +I Y
Sbjct: 446 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYL 504
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 505 LGPDA--PPE------------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF YNF V E +G + TD D+G N+ +T I
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 610
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 611 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 667
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 668 DNKPVF 673
Score = 77.8 bits (183), Expect = 3e-13
Identities = 157/658 (23%), Positives = 255/658 (38%), Gaps = 104/658 (15%)
Query: 770 IYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL 829
+ ++ IED NDN P+F I ENS I ++ + A D D G N + Y L
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLP---AAVDPDVGINGVQNYEL 178
Query: 830 FGE----GKEMFDVDENTGVVKFI-GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIM 882
G ++ + E + + I LDRE+K Y + + D G SS A L +
Sbjct: 179 IKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238
Query: 883 IGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPE 942
+ D NDN P F + E I N G ++ ++ A D D I E
Sbjct: 239 VTDTNDNHPVFKETE------IEVSIPENAPVGTSVTQL-----HATDAD-------IGE 280
Query: 943 NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRY-FVINERHGHV 1001
N I + +L S + ++ + N+ + K D E + ++ G +
Sbjct: 281 NAK-----IHFSFSNLVSNIARRL-FHLNATTGLITIKEPLDREETPNHKLLVLASDGGL 334
Query: 1002 IVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTR 1061
+ AR++ + ++ D + +I +R V VND + + N T+
Sbjct: 335 MPARAM-------VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN--------TK 379
Query: 1062 RVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETEDKYIL 1118
L V DAD N +T F +D ++PF + P+ +L LD E+ +Y +
Sbjct: 380 IALITVTDKDAD--HNGRVTCF---TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAI 434
Query: 1119 TVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMM 1178
++A D G D NDN+P F + PE + + M
Sbjct: 435 KLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPENNSPGIQLTKVSAM 491
Query: 1179 IPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL--------GLP 1230
+ N +G F+ D G ++ L + K + L G+P
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLD---CRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 548
Query: 1231 SLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEHYENF 1288
L+S + V++ D D + PVF Y + EN+ + V L+++ ++ +N
Sbjct: 549 PLTSNVTVFVSIIDQND-----NSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ IL+END F ID + G + S DRE +++Y V+
Sbjct: 604 AVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK-------------- 644
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAPFGYQVMQL 1404
AED KV + + DVNDN P F N +P+T P G V Q+
Sbjct: 645 ---AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQV 698
Score = 77.4 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 488 VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE-----DKYLFTIL 541
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + YN + ENLP +V + TD D G+
Sbjct: 542 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 601
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 602 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 647
Score = 76.2 bits (179), Expect = 9e-13
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 21/178 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A+D D+G+ YELI + +F LD + L ++KELD + + +T+
Sbjct: 163 AVDPDVGINGVQNYELIKSQN--IFGLDVIETPEGDKMPQLIVQKELDRE-----EKDTY 215
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V++V+ P +++ A +++ + D NDN P F+ +SI EN P G SV Q+ ATD
Sbjct: 216 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 275
Query: 333 KDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D GEN + + + + F ++ +G +T++ LDRE + ++ V A +
Sbjct: 276 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP--LDREETPNHKLLVLASD 331
Score = 67.7 bits (158), Expect = 3e-10
Identities = 82/341 (24%), Positives = 143/341 (41%), Gaps = 47/341 (13%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTV 134
++I + + IED+NDN P+F T ++++ E + K L A + P + I
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK--YTLPAAVDPDVGI--NG 172
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR-KVLDYDAG 193
+ + K F D TP D ++ + L+ K +++ KV D
Sbjct: 173 VQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE-----LDREEKDTYVMKVKVEDGGFP 227
Query: 194 DKEFQLVIMASG----------KRIHKEILFPE---------PIHAIDQDLGVGATLRYE 234
+ ++ S K E+ PE +HA D D+G A + +
Sbjct: 228 QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFS 287
Query: 235 ---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQAR 291
L+S R+LF L++ G + +++ LD + N + L V AS + L A+A
Sbjct: 288 FSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----LLVLAS--DGGLMPARAM 340
Query: 292 VEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN+P ++ + N ++V EN+P + + TDKD NG T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-F 399
Query: 346 DDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D + F + P S + LD E+ +K+ A +
Sbjct: 400 TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAAD 440
Score = 64.1 bits (149), Expect = 4e-09
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 413 SNQFLLETAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 469
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G + +V A D D G N + Y L D FS+D R+G LTV +
Sbjct: 470 FVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-- 527
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 528 LDREKEDKYLFTILAKD 544
Score = 63.3 bits (147), Expect = 6e-09
Identities = 103/485 (21%), Positives = 185/485 (38%), Gaps = 50/485 (10%)
Query: 940 IPENIPIGTTIIKLN-ALDLDSGLNGQIRYEFNSEVY-IPPSKLSADALEVKRYFVINER 997
+PEN+ IG + LN +L + L ++++ + +P ++ D E+ F R
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEI---FTTGAR 90
Query: 998 HGHVIVARSLPPESEFRLNIS-ALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ +P + + A+ + + +R ++D+ND+ P+F T N ++ E
Sbjct: 91 IDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPE 150
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGELDRE 1111
A D D G N Y + S ++ L V ELDRE
Sbjct: 151 NSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE 210
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
+D Y++ V D G D NDN P F + +E PE +
Sbjct: 211 EKDTYVMKVKVEDGG-FPQRSSTAILQVSVTDTNDNHPVFKETE--IEVSIPENAPVGT- 266
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLP----QRKNQ 1224
SV + A I ENA I + + + +N + + N GLI P + N
Sbjct: 267 ---SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 1225 QNLGLPS----LSSTAILMVTVADVPDEVEMSDKPVFISRYYE-LEIEENVNAPVELVSL 1279
+ L L S + + A+++V V DV D V D ++ + + + EN+ ++ +
Sbjct: 324 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 383
Query: 1280 NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQK 1339
+T+ + R +++ R R V ++ A
Sbjct: 384 TVTDKDADHNGRVTCFTDHEIPFRL------------------RPVFSNQFLLETAAYLD 425
Query: 1340 YSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGY 1399
Y + I +A D + + +++KD NDN+P FT + +IP G
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF--VTVSIPENNSPGI 483
Query: 1400 QVMQL 1404
Q+ ++
Sbjct: 484 QLTKV 488
Score = 58.4 bits (135), Expect = 2e-07
Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 644
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V N S LP+ G V QV+A D D
Sbjct: 645 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDND 704
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 705 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 750
Score = 52.8 bits (121), Expect = 9e-06
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ PSN YE + S GTV+ +V AVD D G N V Y
Sbjct: 655 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 714 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 768
Query: 556 TIEV 559
+ V
Sbjct: 769 NLFV 772
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/206 (24%), Positives = 93/206 (45%), Gaps = 27/206 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSLTI 130
G+ +++ ++V V I D NDN P+F Y+ V E P G I + P G + +
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 605
Query: 131 PL---------TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L T+ + + +FDR+K + + V D G + SS K
Sbjct: 606 TLSILDENDDFTIDSQTGVIRPNISFDREKQES-----YTFYVKAEDGGRVSRSSSAKVT 660
Query: 182 LLLRKVLD------YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
+ + V D + ++LV+ ++ ++F + A+D D G+ A +RY +
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT---VVFQ--VIAVDNDTGMNAEVRYSI 715
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDL 261
+ GN R LF++D G++ L ++ D+
Sbjct: 716 VGGNTRDLFAIDQETGNITLMEKCDV 741
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/114 (29%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS--LTIPLTVPRGLT 139
S T Y++ D + + VT++ + K +F++ P S L +P T P G
Sbjct: 638 SYTFYVK-AEDGGRVSRSSSAKVTINVVDVNDNKP-VFIVPPSNCSYELVLPSTNP-GTV 694
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 695 VFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 745
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
LT A D+D G NA I Y + + P F++D +G + VV L R+
Sbjct: 485 LTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 225 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 265
>AF332217-1|AAK13469.1| 1340|Homo sapiens protocadherin 11 protein.
Length = 1340
Score = 138 bits (333), Expect = 2e-31
Identities = 138/517 (26%), Positives = 224/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 243 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 295
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 296 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 355
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 356 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 409
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + ++++ + + ++
Sbjct: 410 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLENAAYLDYESTKEYAIK 467
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ Q+ + +
Sbjct: 468 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI--QLMKVSATDA 525
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ +L+ D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 526 DSGPNAEINYLLG--PDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 582
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y+ ++ EN + GT +I TD D G N+
Sbjct: 583 TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 638
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 639 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 696
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 697 DVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAV 733
Score = 116 bits (278), Expect = 9e-25
Identities = 124/424 (29%), Positives = 193/424 (45%), Gaps = 50/424 (11%)
Query: 931 VDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKR 990
V+ + ++ ENIP+ T I + D D+ NG++ + E+ P +L
Sbjct: 393 VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI---PFRLRP---VFSN 446
Query: 991 YFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK 1046
F++ A L ES E+ + + A D G LN + + + VKD ND+ PVF
Sbjct: 447 QFLLEN-------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFT 499
Query: 1047 KTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
+++ ++ E L KV ATDAD G NA + Y + P D F + TG+L+V
Sbjct: 500 QSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGP-DAPPEFSLDRRTGMLTVVK 558
Query: 1107 ELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEAD 1166
+LDRE EDKY+ T++A+DNG D NDNSP F E+K +
Sbjct: 559 KLDREKEDKYLFTILAKDNG-VPPLTSNVTVFVSIIDQNDNSPVF----THNEYKFYVPE 613
Query: 1167 ELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLP-QRKNQQ 1225
L H +V +I V +N+ + T++ + ND I + G+I ++ R+ Q+
Sbjct: 614 NLPRHG--TVGLITVTDPDYGDNSAV--TLSILDENDDFTIDSQTGVIRPNISFDREKQE 669
Query: 1226 NL---------GLPSLSSTAILMVTVADVPDEVEMSDKPVFI----SRYYELEI-EENVN 1271
+ G S SS+A + + V DV D +KPVFI + YEL + N
Sbjct: 670 SYTFYVKAEDGGRVSRSSSAKVTINVVDVND-----NKPVFIVPPYNYSYELVLPSTNPG 724
Query: 1272 APVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEV 1331
V V + N ++RY I+ N D+ F ID G + L+ D + V
Sbjct: 725 TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRV 781
Query: 1332 IVRA 1335
+V+A
Sbjct: 782 LVKA 785
Score = 115 bits (276), Expect = 2e-24
Identities = 119/493 (24%), Positives = 209/493 (42%), Gaps = 25/493 (5%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+++ V + + D NDN P+F P+ + S+ N+ + + AVDPD+G NG+
Sbjct: 149 DEIFRLVKIRFLIEDINDNAPLF-PATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 207
Query: 497 YDLQRTSNLTITSPFKINPNTGTVS--VAESPILEGRHALFVEASDQPANPSERRYSLAV 554
Y+L ++ N+ + P + + + + +V +R S A+
Sbjct: 208 YELIKSQNIFGLDVIE-TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 266
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQN---DVSYDL 610
+ + VT T N P F E + N +GTSV Q+ DA +N S+
Sbjct: 267 LQVSVT-DTNDNH---PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN 322
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L F + +G+IT+ + L R P + +A + + V+V DVN
Sbjct: 323 LVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDGGLMPARAMVLVNVTDVN 381
Query: 671 DE-RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D + ++ +P+ V + +I ++ + G V ++
Sbjct: 382 DNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 441
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVI-AEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ + LD E Y + ++ A+ K ++ + + + I ++DENDN PVF
Sbjct: 442 PVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKDENDNAPVFT 499
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ I EN+ G ++ + ATDAD G NA Y L + F +D TG++
Sbjct: 500 QSFVTVSIPENNSPGIQLMK---VSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTV 556
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHR 906
+ LDREK+ Y +++A+D G L+S + + I D+NDN P F E K +
Sbjct: 557 V-KKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNE--YKFYVPE 613
Query: 907 ETKLNGTAGFTII 919
+GT G +
Sbjct: 614 NLPRHGTVGLITV 626
Score = 97.1 bits (231), Expect = 4e-19
Identities = 80/246 (32%), Positives = 107/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G ++K++A D DSG N +I Y
Sbjct: 478 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYL 536
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 537 LGPDA--PPE------------FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 582
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF Y F V E +G + TD D+G N+ +T I
Sbjct: 583 TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 642
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 643 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 699
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 700 DNKPVF 705
Score = 89.4 bits (212), Expect = 9e-17
Identities = 117/467 (25%), Positives = 195/467 (41%), Gaps = 66/467 (14%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN I + A+D D G+NG YE I D +E ++
Sbjct: 180 IPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNI----FGLDVIETPE----GDKMP 231
Query: 1000 HVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+IV + L E + + + + DGG + ++V V D ND+ PVFK+T ++
Sbjct: 232 QLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIP 291
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP---FEISPLTGVLSVNGELDRET 1112
E + ++ ATDAD G+NA + + +++ F ++ TG++++ LDRE
Sbjct: 292 ENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREE 351
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE-LSNH 1171
+ L V+A D G DVNDN P ++ +P D + +
Sbjct: 352 TPNHKLLVLASDGG---LMPARAMVLVNVTDVNDNVPSI----DIRYIVNPVNDTVVLSE 404
Query: 1172 NF---ESVMMIPVYKATIEENA--------PIGTTVAKVFANDTDFIGNGNGLILYSLPQ 1220
N + +I V + N I + VF+N + N L S +
Sbjct: 405 NIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQF-LLENAAYLDYESTKE 463
Query: 1221 ---RKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELV 1277
+ + G P L+ +A+L + V D E + PVF + + I EN + ++L+
Sbjct: 464 YAIKLLAADAGKPPLNQSAMLFIKVKD-----ENDNAPVFTQSFVTVSIPENNSPGIQLM 518
Query: 1278 SLNLT--EHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
++ T + N ++ Y + D F +D R G L +V+ DRE +D Y + A
Sbjct: 519 KVSATDADSGPNAEINYLL----GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILA 574
Query: 1336 ERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTN 1382
+ + + P+ +V V V I D NDNSP FT+
Sbjct: 575 K--------DNGVPPLTS---------NVTVFVSIIDQNDNSPVFTH 604
Score = 77.0 bits (181), Expect = 5e-13
Identities = 161/662 (24%), Positives = 259/662 (39%), Gaps = 112/662 (16%)
Query: 770 IYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL 829
+ ++ IED NDN P+F I ENS I ++ + A D D G N + Y L
Sbjct: 154 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLP---AAVDPDVGINGVQNYEL 210
Query: 830 FGE----GKEMFDVDENTGVVKFI-GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIM 882
G ++ + E + + I LDRE+K Y + + D G SS A L +
Sbjct: 211 IKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 270
Query: 883 IGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPE 942
+ D NDN P F + E I N G ++ ++ A D D I E
Sbjct: 271 VTDTNDNHPVFKETE------IEVSIPENAPVGTSVTQL-----HATDAD-------IGE 312
Query: 943 NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRY-FVINERHGHV 1001
N I + +L S + ++ + N+ + K D E + ++ G +
Sbjct: 313 NAK-----IHFSFSNLVSNIARRL-FHLNATTGLITIKEPLDREETPNHKLLVLASDGGL 366
Query: 1002 IVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTR 1061
+ AR++ + ++ D + +I +R V VND + + N T+
Sbjct: 367 MPARAM-------VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN--------TK 411
Query: 1062 RVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETEDKYIL 1118
L V DAD N +T F +D ++PF + P+ +L LD E+ +Y +
Sbjct: 412 IALITVTDKDAD--HNGRVTCF---TDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAI 466
Query: 1119 TVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMM 1178
++A D G D NDN+P F + PE +N +M
Sbjct: 467 KLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPE----NNSPGIQLMK 519
Query: 1179 IPVYKATIEENAPI----GTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL------- 1227
+ A NA I G F+ D G ++ L + K + L
Sbjct: 520 VSATDADSGPNAEINYLLGPDAPPEFSLDR---RTGMLTVVKKLDREKEDKYLFTILAKD 576
Query: 1228 -GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEH 1284
G+P L+S + V++ D D + PVF Y+ + EN+ + V L+++ ++
Sbjct: 577 NGVPPLTSNVTVFVSIIDQND-----NSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDY 631
Query: 1285 YENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSREL 1344
+N + IL+END F ID + G + S DRE +++Y V+
Sbjct: 632 GDNSAVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK---------- 676
Query: 1345 PHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAPFGYQVM 1402
AED KV + + DVNDN P F N +P+T P G V
Sbjct: 677 -------AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNP-GTVVF 728
Query: 1403 QL 1404
Q+
Sbjct: 729 QV 730
Score = 76.2 bits (179), Expect = 9e-13
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 21/178 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A+D D+G+ YELI + +F LD + L ++KELD + + +T+
Sbjct: 195 AVDPDVGINGVQNYELIKSQN--IFGLDVIETPEGDKMPQLIVQKELDRE-----EKDTY 247
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V++V+ P +++ A +++ + D NDN P F+ +SI EN P G SV Q+ ATD
Sbjct: 248 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 307
Query: 333 KDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D GEN + + + + F ++ +G +T++ LDRE + ++ V A +
Sbjct: 308 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP--LDREETPNHKLLVLASD 363
Score = 74.1 bits (174), Expect = 3e-12
Identities = 51/168 (30%), Positives = 78/168 (46%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 520 VSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKE-----DKYLFTIL 573
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + Y + ENLP +V + TD D G+
Sbjct: 574 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGD 633
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 634 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 679
Score = 70.1 bits (164), Expect = 6e-11
Identities = 83/341 (24%), Positives = 144/341 (42%), Gaps = 47/341 (13%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTV 134
++I + + IED+NDN P+F T ++++ E + K L A + P + I
Sbjct: 149 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK--YTLPAAVDPDVGI--NG 204
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR-KVLDYDAG 193
+ + K F D TP D ++ + L+ K +++ KV D
Sbjct: 205 VQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE-----LDREEKDTYVMKVKVEDGGFP 259
Query: 194 DKEFQLVIMASG----------KRIHKEILFPE---------PIHAIDQDLGVGATLRYE 234
+ ++ S K E+ PE +HA D D+G A + +
Sbjct: 260 QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFS 319
Query: 235 ---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQAR 291
L+S R+LF L++ G + +++ LD + N + L V AS + L A+A
Sbjct: 320 FSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----LLVLAS--DGGLMPARAM 372
Query: 292 VEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN+P ++ + N ++V EN+P + + TDKD NG T
Sbjct: 373 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-F 431
Query: 346 DDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D + F + P S + N LD E+ +K+ A +
Sbjct: 432 TDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAAD 472
Score = 70.1 bits (164), Expect = 6e-11
Identities = 46/137 (33%), Positives = 65/137 (47%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 445 SNQFLLENAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 501
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G +++V ATD D G N E Y L D FS+D R+G LTV +
Sbjct: 502 FVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKK-- 559
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 560 LDREKEDKYLFTILAKD 576
Score = 67.7 bits (158), Expect = 3e-10
Identities = 105/485 (21%), Positives = 186/485 (38%), Gaps = 50/485 (10%)
Query: 940 IPENIPIGTTIIKLN-ALDLDSGLNGQIRYEFNSEVY-IPPSKLSADALEVKRYFVINER 997
IPEN+ IG + LN +L + L ++++ + +P ++ D E+ F R
Sbjct: 66 IPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEI---FTTGAR 122
Query: 998 HGHVIVARSLPPESEFRLNIS-ALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ +P + + A+ + + +R ++D+ND+ P+F T N ++ E
Sbjct: 123 IDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPE 182
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGELDRE 1111
A D D G N Y + S ++ L V ELDRE
Sbjct: 183 NSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE 242
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
+D Y++ V D G D NDN P F + +E PE +
Sbjct: 243 EKDTYVMKVKVEDGG-FPQRSSTAILQVSVTDTNDNHPVFKETE--IEVSIPENAPVGT- 298
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLP----QRKNQ 1224
SV + A I ENA I + + + +N + + N GLI P + N
Sbjct: 299 ---SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 355
Query: 1225 QNLGLPS----LSSTAILMVTVADVPDEVEMSDKPVFISRYYE-LEIEENVNAPVELVSL 1279
+ L L S + + A+++V V DV D V D ++ + + + EN+ ++ +
Sbjct: 356 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 415
Query: 1280 NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQK 1339
+T+ + R +++ R R V ++ A
Sbjct: 416 TVTDKDADHNGRVTCFTDHEIPFRL------------------RPVFSNQFLLENAAYLD 457
Query: 1340 YSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGY 1399
Y + I +A D + + +++KD NDN+P FT + +IP G
Sbjct: 458 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF--VTVSIPENNSPGI 515
Query: 1400 QVMQL 1404
Q+M++
Sbjct: 516 QLMKV 520
Score = 62.1 bits (144), Expect = 1e-08
Identities = 49/166 (29%), Positives = 78/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 624 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 676
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V YN S LP+ G V QV+A D D
Sbjct: 677 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDND 736
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 737 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 782
Score = 50.4 bits (115), Expect = 5e-05
Identities = 39/124 (31%), Positives = 62/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ P N YE + S GTV+ +V AVD D G N V Y
Sbjct: 687 SSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 745
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 746 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 800
Query: 556 TIEV 559
+ V
Sbjct: 801 NLFV 804
Score = 40.7 bits (91), Expect = 0.039
Identities = 36/116 (31%), Positives = 53/116 (45%), Gaps = 24/116 (20%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRG 137
S+ VT+ + DVNDN P+F+ PY+ + + L +P T P G
Sbjct: 686 SSSAKVTINVVDVNDNKPVFIVPPYNYSYE--------------------LVLPSTNP-G 724
Query: 138 LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 725 TVVFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 777
Score = 35.9 bits (79), Expect = 1.1
Identities = 18/47 (38%), Positives = 27/47 (57%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
L ATD+D G NA+I Y + + P F++D +G + VV L R+
Sbjct: 517 LMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 563
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 257 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 297
>AF332216-1|AAK13468.1| 1048|Homo sapiens protocadherin 11 protein.
Length = 1048
Score = 138 bits (333), Expect = 2e-31
Identities = 138/517 (26%), Positives = 224/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 243 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 295
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 296 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 355
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 356 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 409
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + ++++ + + ++
Sbjct: 410 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLENAAYLDYESTKEYAIK 467
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ Q+ + +
Sbjct: 468 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI--QLMKVSATDA 525
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ +L+ D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 526 DSGPNAEINYLLG--PDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 582
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y+ ++ EN + GT +I TD D G N+
Sbjct: 583 TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 638
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 639 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 696
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 697 DVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAV 733
Score = 116 bits (278), Expect = 9e-25
Identities = 124/424 (29%), Positives = 193/424 (45%), Gaps = 50/424 (11%)
Query: 931 VDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKR 990
V+ + ++ ENIP+ T I + D D+ NG++ + E+ P +L
Sbjct: 393 VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI---PFRLRP---VFSN 446
Query: 991 YFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK 1046
F++ A L ES E+ + + A D G LN + + + VKD ND+ PVF
Sbjct: 447 QFLLEN-------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFT 499
Query: 1047 KTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
+++ ++ E L KV ATDAD G NA + Y + P D F + TG+L+V
Sbjct: 500 QSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGP-DAPPEFSLDRRTGMLTVVK 558
Query: 1107 ELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEAD 1166
+LDRE EDKY+ T++A+DNG D NDNSP F E+K +
Sbjct: 559 KLDREKEDKYLFTILAKDNG-VPPLTSNVTVFVSIIDQNDNSPVF----THNEYKFYVPE 613
Query: 1167 ELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLP-QRKNQQ 1225
L H +V +I V +N+ + T++ + ND I + G+I ++ R+ Q+
Sbjct: 614 NLPRHG--TVGLITVTDPDYGDNSAV--TLSILDENDDFTIDSQTGVIRPNISFDREKQE 669
Query: 1226 NL---------GLPSLSSTAILMVTVADVPDEVEMSDKPVFI----SRYYELEI-EENVN 1271
+ G S SS+A + + V DV D +KPVFI + YEL + N
Sbjct: 670 SYTFYVKAEDGGRVSRSSSAKVTINVVDVND-----NKPVFIVPPYNYSYELVLPSTNPG 724
Query: 1272 APVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEV 1331
V V + N ++RY I+ N D+ F ID G + L+ D + V
Sbjct: 725 TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRV 781
Query: 1332 IVRA 1335
+V+A
Sbjct: 782 LVKA 785
Score = 115 bits (276), Expect = 2e-24
Identities = 119/493 (24%), Positives = 209/493 (42%), Gaps = 25/493 (5%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+++ V + + D NDN P+F P+ + S+ N+ + + AVDPD+G NG+
Sbjct: 149 DEIFRLVKIRFLIEDINDNAPLF-PATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 207
Query: 497 YDLQRTSNLTITSPFKINPNTGTVS--VAESPILEGRHALFVEASDQPANPSERRYSLAV 554
Y+L ++ N+ + P + + + + +V +R S A+
Sbjct: 208 YELIKSQNIFGLDVIE-TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 266
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQN---DVSYDL 610
+ + VT T N P F E + N +GTSV Q+ DA +N S+
Sbjct: 267 LQVSVT-DTNDNH---PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN 322
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L F + +G+IT+ + L R P + +A + + V+V DVN
Sbjct: 323 LVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDGGLMPARAMVLVNVTDVN 381
Query: 671 DE-RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D + ++ +P+ V + +I ++ + G V ++
Sbjct: 382 DNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 441
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVI-AEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ + LD E Y + ++ A+ K ++ + + + I ++DENDN PVF
Sbjct: 442 PVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKDENDNAPVFT 499
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ I EN+ G ++ + ATDAD G NA Y L + F +D TG++
Sbjct: 500 QSFVTVSIPENNSPGIQLMK---VSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTV 556
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHR 906
+ LDREK+ Y +++A+D G L+S + + I D+NDN P F E K +
Sbjct: 557 V-KKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNE--YKFYVPE 613
Query: 907 ETKLNGTAGFTII 919
+GT G +
Sbjct: 614 NLPRHGTVGLITV 626
Score = 97.1 bits (231), Expect = 4e-19
Identities = 80/246 (32%), Positives = 107/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G ++K++A D DSG N +I Y
Sbjct: 478 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYL 536
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 537 LGPDA--PPE------------FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 582
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF Y F V E +G + TD D+G N+ +T I
Sbjct: 583 TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 642
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 643 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 699
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 700 DNKPVF 705
Score = 89.4 bits (212), Expect = 9e-17
Identities = 117/467 (25%), Positives = 195/467 (41%), Gaps = 66/467 (14%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN I + A+D D G+NG YE I D +E ++
Sbjct: 180 IPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNI----FGLDVIETPE----GDKMP 231
Query: 1000 HVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+IV + L E + + + + DGG + ++V V D ND+ PVFK+T ++
Sbjct: 232 QLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIP 291
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP---FEISPLTGVLSVNGELDRET 1112
E + ++ ATDAD G+NA + + +++ F ++ TG++++ LDRE
Sbjct: 292 ENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREE 351
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE-LSNH 1171
+ L V+A D G DVNDN P ++ +P D + +
Sbjct: 352 TPNHKLLVLASDGG---LMPARAMVLVNVTDVNDNVPSI----DIRYIVNPVNDTVVLSE 404
Query: 1172 NF---ESVMMIPVYKATIEENA--------PIGTTVAKVFANDTDFIGNGNGLILYSLPQ 1220
N + +I V + N I + VF+N + N L S +
Sbjct: 405 NIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQF-LLENAAYLDYESTKE 463
Query: 1221 ---RKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELV 1277
+ + G P L+ +A+L + V D E + PVF + + I EN + ++L+
Sbjct: 464 YAIKLLAADAGKPPLNQSAMLFIKVKD-----ENDNAPVFTQSFVTVSIPENNSPGIQLM 518
Query: 1278 SLNLT--EHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
++ T + N ++ Y + D F +D R G L +V+ DRE +D Y + A
Sbjct: 519 KVSATDADSGPNAEINYLL----GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILA 574
Query: 1336 ERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTN 1382
+ + + P+ +V V V I D NDNSP FT+
Sbjct: 575 K--------DNGVPPLTS---------NVTVFVSIIDQNDNSPVFTH 604
Score = 77.0 bits (181), Expect = 5e-13
Identities = 161/662 (24%), Positives = 259/662 (39%), Gaps = 112/662 (16%)
Query: 770 IYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL 829
+ ++ IED NDN P+F I ENS I ++ + A D D G N + Y L
Sbjct: 154 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLP---AAVDPDVGINGVQNYEL 210
Query: 830 FGE----GKEMFDVDENTGVVKFI-GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIM 882
G ++ + E + + I LDRE+K Y + + D G SS A L +
Sbjct: 211 IKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 270
Query: 883 IGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPE 942
+ D NDN P F + E I N G ++ ++ A D D I E
Sbjct: 271 VTDTNDNHPVFKETE------IEVSIPENAPVGTSVTQL-----HATDAD-------IGE 312
Query: 943 NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRY-FVINERHGHV 1001
N I + +L S + ++ + N+ + K D E + ++ G +
Sbjct: 313 NAK-----IHFSFSNLVSNIARRL-FHLNATTGLITIKEPLDREETPNHKLLVLASDGGL 366
Query: 1002 IVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTR 1061
+ AR++ + ++ D + +I +R V VND + + N T+
Sbjct: 367 MPARAM-------VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN--------TK 411
Query: 1062 RVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETEDKYIL 1118
L V DAD N +T F +D ++PF + P+ +L LD E+ +Y +
Sbjct: 412 IALITVTDKDAD--HNGRVTCF---TDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAI 466
Query: 1119 TVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMM 1178
++A D G D NDN+P F + PE +N +M
Sbjct: 467 KLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPE----NNSPGIQLMK 519
Query: 1179 IPVYKATIEENAPI----GTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL------- 1227
+ A NA I G F+ D G ++ L + K + L
Sbjct: 520 VSATDADSGPNAEINYLLGPDAPPEFSLDR---RTGMLTVVKKLDREKEDKYLFTILAKD 576
Query: 1228 -GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEH 1284
G+P L+S + V++ D D + PVF Y+ + EN+ + V L+++ ++
Sbjct: 577 NGVPPLTSNVTVFVSIIDQND-----NSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDY 631
Query: 1285 YENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSREL 1344
+N + IL+END F ID + G + S DRE +++Y V+
Sbjct: 632 GDNSAVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK---------- 676
Query: 1345 PHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAPFGYQVM 1402
AED KV + + DVNDN P F N +P+T P G V
Sbjct: 677 -------AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNP-GTVVF 728
Query: 1403 QL 1404
Q+
Sbjct: 729 QV 730
Score = 76.2 bits (179), Expect = 9e-13
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 21/178 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A+D D+G+ YELI + +F LD + L ++KELD + + +T+
Sbjct: 195 AVDPDVGINGVQNYELIKSQN--IFGLDVIETPEGDKMPQLIVQKELDRE-----EKDTY 247
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V++V+ P +++ A +++ + D NDN P F+ +SI EN P G SV Q+ ATD
Sbjct: 248 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 307
Query: 333 KDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D GEN + + + + F ++ +G +T++ LDRE + ++ V A +
Sbjct: 308 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP--LDREETPNHKLLVLASD 363
Score = 74.1 bits (174), Expect = 3e-12
Identities = 51/168 (30%), Positives = 78/168 (46%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 520 VSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKE-----DKYLFTIL 573
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + Y + ENLP +V + TD D G+
Sbjct: 574 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGD 633
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 634 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 679
Score = 70.1 bits (164), Expect = 6e-11
Identities = 83/341 (24%), Positives = 144/341 (42%), Gaps = 47/341 (13%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTV 134
++I + + IED+NDN P+F T ++++ E + K L A + P + I
Sbjct: 149 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK--YTLPAAVDPDVGI--NG 204
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR-KVLDYDAG 193
+ + K F D TP D ++ + L+ K +++ KV D
Sbjct: 205 VQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE-----LDREEKDTYVMKVKVEDGGFP 259
Query: 194 DKEFQLVIMASG----------KRIHKEILFPE---------PIHAIDQDLGVGATLRYE 234
+ ++ S K E+ PE +HA D D+G A + +
Sbjct: 260 QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFS 319
Query: 235 ---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQAR 291
L+S R+LF L++ G + +++ LD + N + L V AS + L A+A
Sbjct: 320 FSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----LLVLAS--DGGLMPARAM 372
Query: 292 VEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN+P ++ + N ++V EN+P + + TDKD NG T
Sbjct: 373 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-F 431
Query: 346 DDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D + F + P S + N LD E+ +K+ A +
Sbjct: 432 TDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAAD 472
Score = 70.1 bits (164), Expect = 6e-11
Identities = 46/137 (33%), Positives = 65/137 (47%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 445 SNQFLLENAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 501
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G +++V ATD D G N E Y L D FS+D R+G LTV +
Sbjct: 502 FVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKK-- 559
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 560 LDREKEDKYLFTILAKD 576
Score = 67.7 bits (158), Expect = 3e-10
Identities = 105/485 (21%), Positives = 186/485 (38%), Gaps = 50/485 (10%)
Query: 940 IPENIPIGTTIIKLN-ALDLDSGLNGQIRYEFNSEVY-IPPSKLSADALEVKRYFVINER 997
IPEN+ IG + LN +L + L ++++ + +P ++ D E+ F R
Sbjct: 66 IPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEI---FTTGAR 122
Query: 998 HGHVIVARSLPPESEFRLNIS-ALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ +P + + A+ + + +R ++D+ND+ P+F T N ++ E
Sbjct: 123 IDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPE 182
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGELDRE 1111
A D D G N Y + S ++ L V ELDRE
Sbjct: 183 NSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE 242
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
+D Y++ V D G D NDN P F + +E PE +
Sbjct: 243 EKDTYVMKVKVEDGG-FPQRSSTAILQVSVTDTNDNHPVFKETE--IEVSIPENAPVGT- 298
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLP----QRKNQ 1224
SV + A I ENA I + + + +N + + N GLI P + N
Sbjct: 299 ---SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 355
Query: 1225 QNLGLPS----LSSTAILMVTVADVPDEVEMSDKPVFISRYYE-LEIEENVNAPVELVSL 1279
+ L L S + + A+++V V DV D V D ++ + + + EN+ ++ +
Sbjct: 356 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 415
Query: 1280 NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQK 1339
+T+ + R +++ R R V ++ A
Sbjct: 416 TVTDKDADHNGRVTCFTDHEIPFRL------------------RPVFSNQFLLENAAYLD 457
Query: 1340 YSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGY 1399
Y + I +A D + + +++KD NDN+P FT + +IP G
Sbjct: 458 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF--VTVSIPENNSPGI 515
Query: 1400 QVMQL 1404
Q+M++
Sbjct: 516 QLMKV 520
Score = 62.1 bits (144), Expect = 1e-08
Identities = 49/166 (29%), Positives = 78/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 624 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 676
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V YN S LP+ G V QV+A D D
Sbjct: 677 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDND 736
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 737 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 782
Score = 50.4 bits (115), Expect = 5e-05
Identities = 39/124 (31%), Positives = 62/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ P N YE + S GTV+ +V AVD D G N V Y
Sbjct: 687 SSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 745
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 746 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 800
Query: 556 TIEV 559
+ V
Sbjct: 801 NLFV 804
Score = 40.7 bits (91), Expect = 0.039
Identities = 36/116 (31%), Positives = 53/116 (45%), Gaps = 24/116 (20%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRG 137
S+ VT+ + DVNDN P+F+ PY+ + + L +P T P G
Sbjct: 686 SSSAKVTINVVDVNDNKPVFIVPPYNYSYE--------------------LVLPSTNP-G 724
Query: 138 LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 725 TVVFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 777
Score = 35.9 bits (79), Expect = 1.1
Identities = 18/47 (38%), Positives = 27/47 (57%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
L ATD+D G NA+I Y + + P F++D +G + VV L R+
Sbjct: 517 LMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 563
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 257 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 297
>AF277053-1|AAL55729.1| 1037|Homo sapiens protocadherin-PC protein.
Length = 1037
Score = 138 bits (333), Expect = 2e-31
Identities = 138/517 (26%), Positives = 224/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 232 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 284
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 285 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 344
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 345 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 398
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + ++++ + + ++
Sbjct: 399 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLENAAYLDYESTKEYAIK 456
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ Q+ + +
Sbjct: 457 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI--QLMKVSATDA 514
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ +L+ D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 515 DSGPNAEINYLLG--PDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 571
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y+ ++ EN + GT +I TD D G N+
Sbjct: 572 TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 627
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 628 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 685
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 686 DVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAV 722
Score = 116 bits (278), Expect = 9e-25
Identities = 124/424 (29%), Positives = 193/424 (45%), Gaps = 50/424 (11%)
Query: 931 VDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKR 990
V+ + ++ ENIP+ T I + D D+ NG++ + E+ P +L
Sbjct: 382 VNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI---PFRLRP---VFSN 435
Query: 991 YFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK 1046
F++ A L ES E+ + + A D G LN + + + VKD ND+ PVF
Sbjct: 436 QFLLEN-------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFT 488
Query: 1047 KTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
+++ ++ E L KV ATDAD G NA + Y + P D F + TG+L+V
Sbjct: 489 QSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGP-DAPPEFSLDRRTGMLTVVK 547
Query: 1107 ELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEAD 1166
+LDRE EDKY+ T++A+DNG D NDNSP F E+K +
Sbjct: 548 KLDREKEDKYLFTILAKDNG-VPPLTSNVTVFVSIIDQNDNSPVF----THNEYKFYVPE 602
Query: 1167 ELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLP-QRKNQQ 1225
L H +V +I V +N+ + T++ + ND I + G+I ++ R+ Q+
Sbjct: 603 NLPRHG--TVGLITVTDPDYGDNSAV--TLSILDENDDFTIDSQTGVIRPNISFDREKQE 658
Query: 1226 NL---------GLPSLSSTAILMVTVADVPDEVEMSDKPVFI----SRYYELEI-EENVN 1271
+ G S SS+A + + V DV D +KPVFI + YEL + N
Sbjct: 659 SYTFYVKAEDGGRVSRSSSAKVTINVVDVND-----NKPVFIVPPYNYSYELVLPSTNPG 713
Query: 1272 APVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEV 1331
V V + N ++RY I+ N D+ F ID G + L+ D + V
Sbjct: 714 TVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRV 770
Query: 1332 IVRA 1335
+V+A
Sbjct: 771 LVKA 774
Score = 115 bits (276), Expect = 2e-24
Identities = 119/493 (24%), Positives = 209/493 (42%), Gaps = 25/493 (5%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+++ V + + D NDN P+F P+ + S+ N+ + + AVDPD+G NG+
Sbjct: 138 DEIFRLVKIRFLIEDINDNAPLF-PATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 196
Query: 497 YDLQRTSNLTITSPFKINPNTGTVS--VAESPILEGRHALFVEASDQPANPSERRYSLAV 554
Y+L ++ N+ + P + + + + +V +R S A+
Sbjct: 197 YELIKSQNIFGLDVIE-TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 255
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQN---DVSYDL 610
+ + VT T N P F E + N +GTSV Q+ DA +N S+
Sbjct: 256 LQVSVT-DTNDNH---PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN 311
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L F + +G+IT+ + L R P + +A + + V+V DVN
Sbjct: 312 LVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDGGLMPARAMVLVNVTDVN 370
Query: 671 DE-RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D + ++ +P+ V + +I ++ + G V ++
Sbjct: 371 DNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 430
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVI-AEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ + LD E Y + ++ A+ K ++ + + + I ++DENDN PVF
Sbjct: 431 PVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKDENDNAPVFT 488
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ I EN+ G ++ + ATDAD G NA Y L + F +D TG++
Sbjct: 489 QSFVTVSIPENNSPGIQLMK---VSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTV 545
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHR 906
+ LDREK+ Y +++A+D G L+S + + I D+NDN P F E K +
Sbjct: 546 V-KKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNE--YKFYVPE 602
Query: 907 ETKLNGTAGFTII 919
+GT G +
Sbjct: 603 NLPRHGTVGLITV 615
Score = 97.1 bits (231), Expect = 4e-19
Identities = 80/246 (32%), Positives = 107/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G ++K++A D DSG N +I Y
Sbjct: 467 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYL 525
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 526 LGPDA--PPE------------FSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 571
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF Y F V E +G + TD D+G N+ +T I
Sbjct: 572 TSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 631
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 632 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 688
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 689 DNKPVF 694
Score = 89.4 bits (212), Expect = 9e-17
Identities = 117/467 (25%), Positives = 195/467 (41%), Gaps = 66/467 (14%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN I + A+D D G+NG YE I D +E ++
Sbjct: 169 IPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNI----FGLDVIETPE----GDKMP 220
Query: 1000 HVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+IV + L E + + + + DGG + ++V V D ND+ PVFK+T ++
Sbjct: 221 QLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIP 280
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP---FEISPLTGVLSVNGELDRET 1112
E + ++ ATDAD G+NA + + +++ F ++ TG++++ LDRE
Sbjct: 281 ENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREE 340
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE-LSNH 1171
+ L V+A D G DVNDN P ++ +P D + +
Sbjct: 341 TPNHKLLVLASDGG---LMPARAMVLVNVTDVNDNVPSI----DIRYIVNPVNDTVVLSE 393
Query: 1172 NF---ESVMMIPVYKATIEENA--------PIGTTVAKVFANDTDFIGNGNGLILYSLPQ 1220
N + +I V + N I + VF+N + N L S +
Sbjct: 394 NIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQF-LLENAAYLDYESTKE 452
Query: 1221 ---RKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELV 1277
+ + G P L+ +A+L + V D E + PVF + + I EN + ++L+
Sbjct: 453 YAIKLLAADAGKPPLNQSAMLFIKVKD-----ENDNAPVFTQSFVTVSIPENNSPGIQLM 507
Query: 1278 SLNLT--EHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
++ T + N ++ Y + D F +D R G L +V+ DRE +D Y + A
Sbjct: 508 KVSATDADSGPNAEINYLL----GPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILA 563
Query: 1336 ERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTN 1382
+ + + P+ +V V V I D NDNSP FT+
Sbjct: 564 K--------DNGVPPLTS---------NVTVFVSIIDQNDNSPVFTH 593
Score = 77.0 bits (181), Expect = 5e-13
Identities = 161/662 (24%), Positives = 259/662 (39%), Gaps = 112/662 (16%)
Query: 770 IYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL 829
+ ++ IED NDN P+F I ENS I ++ + A D D G N + Y L
Sbjct: 143 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLP---AAVDPDVGINGVQNYEL 199
Query: 830 FGE----GKEMFDVDENTGVVKFI-GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIM 882
G ++ + E + + I LDRE+K Y + + D G SS A L +
Sbjct: 200 IKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 259
Query: 883 IGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPE 942
+ D NDN P F + E I N G ++ ++ A D D I E
Sbjct: 260 VTDTNDNHPVFKETE------IEVSIPENAPVGTSVTQL-----HATDAD-------IGE 301
Query: 943 NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRY-FVINERHGHV 1001
N I + +L S + ++ + N+ + K D E + ++ G +
Sbjct: 302 NAK-----IHFSFSNLVSNIARRL-FHLNATTGLITIKEPLDREETPNHKLLVLASDGGL 355
Query: 1002 IVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTR 1061
+ AR++ + ++ D + +I +R V VND + + N T+
Sbjct: 356 MPARAM-------VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN--------TK 400
Query: 1062 RVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETEDKYIL 1118
L V DAD N +T F +D ++PF + P+ +L LD E+ +Y +
Sbjct: 401 IALITVTDKDAD--HNGRVTCF---TDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAI 455
Query: 1119 TVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMM 1178
++A D G D NDN+P F + PE +N +M
Sbjct: 456 KLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPE----NNSPGIQLMK 508
Query: 1179 IPVYKATIEENAPI----GTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL------- 1227
+ A NA I G F+ D G ++ L + K + L
Sbjct: 509 VSATDADSGPNAEINYLLGPDAPPEFSLDR---RTGMLTVVKKLDREKEDKYLFTILAKD 565
Query: 1228 -GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEH 1284
G+P L+S + V++ D D + PVF Y+ + EN+ + V L+++ ++
Sbjct: 566 NGVPPLTSNVTVFVSIIDQND-----NSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDY 620
Query: 1285 YENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSREL 1344
+N + IL+END F ID + G + S DRE +++Y V+
Sbjct: 621 GDNSAVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK---------- 665
Query: 1345 PHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAPFGYQVM 1402
AED KV + + DVNDN P F N +P+T P G V
Sbjct: 666 -------AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNP-GTVVF 717
Query: 1403 QL 1404
Q+
Sbjct: 718 QV 719
Score = 76.2 bits (179), Expect = 9e-13
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 21/178 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A+D D+G+ YELI + +F LD + L ++KELD + + +T+
Sbjct: 184 AVDPDVGINGVQNYELIKSQN--IFGLDVIETPEGDKMPQLIVQKELDRE-----EKDTY 236
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V++V+ P +++ A +++ + D NDN P F+ +SI EN P G SV Q+ ATD
Sbjct: 237 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 296
Query: 333 KDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D GEN + + + + F ++ +G +T++ LDRE + ++ V A +
Sbjct: 297 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP--LDREETPNHKLLVLASD 352
Score = 74.1 bits (174), Expect = 3e-12
Identities = 51/168 (30%), Positives = 78/168 (46%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 509 VSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKE-----DKYLFTIL 562
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + Y + ENLP +V + TD D G+
Sbjct: 563 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGD 622
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 623 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 668
Score = 70.1 bits (164), Expect = 6e-11
Identities = 83/341 (24%), Positives = 144/341 (42%), Gaps = 47/341 (13%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTV 134
++I + + IED+NDN P+F T ++++ E + K L A + P + I
Sbjct: 138 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK--YTLPAAVDPDVGI--NG 193
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR-KVLDYDAG 193
+ + K F D TP D ++ + L+ K +++ KV D
Sbjct: 194 VQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE-----LDREEKDTYVMKVKVEDGGFP 248
Query: 194 DKEFQLVIMASG----------KRIHKEILFPE---------PIHAIDQDLGVGATLRYE 234
+ ++ S K E+ PE +HA D D+G A + +
Sbjct: 249 QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFS 308
Query: 235 ---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQAR 291
L+S R+LF L++ G + +++ LD + N + L V AS + L A+A
Sbjct: 309 FSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----LLVLAS--DGGLMPARAM 361
Query: 292 VEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN+P ++ + N ++V EN+P + + TDKD NG T
Sbjct: 362 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-F 420
Query: 346 DDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D + F + P S + N LD E+ +K+ A +
Sbjct: 421 TDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAAD 461
Score = 70.1 bits (164), Expect = 6e-11
Identities = 46/137 (33%), Positives = 65/137 (47%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 434 SNQFLLENAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 490
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G +++V ATD D G N E Y L D FS+D R+G LTV +
Sbjct: 491 FVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKK-- 548
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 549 LDREKEDKYLFTILAKD 565
Score = 67.7 bits (158), Expect = 3e-10
Identities = 105/485 (21%), Positives = 186/485 (38%), Gaps = 50/485 (10%)
Query: 940 IPENIPIGTTIIKLN-ALDLDSGLNGQIRYEFNSEVY-IPPSKLSADALEVKRYFVINER 997
IPEN+ IG + LN +L + L ++++ + +P ++ D E+ F R
Sbjct: 55 IPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEI---FTTGAR 111
Query: 998 HGHVIVARSLPPESEFRLNIS-ALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ +P + + A+ + + +R ++D+ND+ P+F T N ++ E
Sbjct: 112 IDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPE 171
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGELDRE 1111
A D D G N Y + S ++ L V ELDRE
Sbjct: 172 NSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE 231
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
+D Y++ V D G D NDN P F + +E PE +
Sbjct: 232 EKDTYVMKVKVEDGG-FPQRSSTAILQVSVTDTNDNHPVFKETE--IEVSIPENAPVGT- 287
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLP----QRKNQ 1224
SV + A I ENA I + + + +N + + N GLI P + N
Sbjct: 288 ---SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 344
Query: 1225 QNLGLPS----LSSTAILMVTVADVPDEVEMSDKPVFISRYYE-LEIEENVNAPVELVSL 1279
+ L L S + + A+++V V DV D V D ++ + + + EN+ ++ +
Sbjct: 345 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 404
Query: 1280 NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQK 1339
+T+ + R +++ R R V ++ A
Sbjct: 405 TVTDKDADHNGRVTCFTDHEIPFRL------------------RPVFSNQFLLENAAYLD 446
Query: 1340 YSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGY 1399
Y + I +A D + + +++KD NDN+P FT + +IP G
Sbjct: 447 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF--VTVSIPENNSPGI 504
Query: 1400 QVMQL 1404
Q+M++
Sbjct: 505 QLMKV 509
Score = 62.1 bits (144), Expect = 1e-08
Identities = 49/166 (29%), Positives = 78/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 613 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 665
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V YN S LP+ G V QV+A D D
Sbjct: 666 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIAVDND 725
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 726 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 771
Score = 50.4 bits (115), Expect = 5e-05
Identities = 39/124 (31%), Positives = 62/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ P N YE + S GTV+ +V AVD D G N V Y
Sbjct: 676 SSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 734
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 735 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 789
Query: 556 TIEV 559
+ V
Sbjct: 790 NLFV 793
Score = 40.7 bits (91), Expect = 0.039
Identities = 36/116 (31%), Positives = 53/116 (45%), Gaps = 24/116 (20%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRG 137
S+ VT+ + DVNDN P+F+ PY+ + + L +P T P G
Sbjct: 675 SSSAKVTINVVDVNDNKPVFIVPPYNYSYE--------------------LVLPSTNP-G 713
Query: 138 LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 714 TVVFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 766
Score = 35.9 bits (79), Expect = 1.1
Identities = 18/47 (38%), Positives = 27/47 (57%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
L ATD+D G NA+I Y + + P F++D +G + VV L R+
Sbjct: 506 LMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 552
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 246 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 286
>AB026187-1|BAA90765.1| 1021|Homo sapiens protocadherin-Xa protein.
Length = 1021
Score = 138 bits (333), Expect = 2e-31
Identities = 140/517 (27%), Positives = 223/517 (43%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D NDN+PVF + + E S+ NA
Sbjct: 211 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DTNDNHPVFKETEI-EVSIPENAP 263
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 264 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 324 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + +++ + + ++
Sbjct: 378 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ I T +S++
Sbjct: 436 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG----IQLTKVSAM 491
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ N + D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 550
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y ++ EN + GT +I TD D G N+
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 606
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 607 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701
Score = 113 bits (273), Expect = 3e-24
Identities = 116/473 (24%), Positives = 203/473 (42%), Gaps = 23/473 (4%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+++ V + + D NDN P+F P+ + S+ N+ + + AVDPD+G NG+
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLF-PATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 497 YDLQRTSNLTITSPFKINPNTGTVS--VAESPILEGRHALFVEASDQPANPSERRYSLAV 554
Y+L ++ N+ + P + + + + +V +R S A+
Sbjct: 176 YELIKSQNIFGLDVIE-TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 234
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQN---DVSYDL 610
+ + VT T N P F E + N +GTSV Q+ DA +N S+
Sbjct: 235 LQVSVT-DTNDNH---PVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN 290
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L F + +G+IT+ + L R P + +A + + V+V DVN
Sbjct: 291 LVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDGGLMPARAMVLVNVTDVN 349
Query: 671 DE-RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D + ++ +P+ V + +I ++ + G V ++
Sbjct: 350 DNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVI-AEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ + T LD E Y + ++ A+ K ++ + + + I ++DENDN PVF
Sbjct: 410 PVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKDENDNAPVFT 467
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ I EN+ G ++ + A DAD G NA Y L + F +D TG++
Sbjct: 468 QSFVTVSIPENNSPGIQLTK---VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTV 524
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
+ LDREK+ Y +++A+D G L+S + + I D+NDN P F E N
Sbjct: 525 V-KKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Score = 97.9 bits (233), Expect = 2e-19
Identities = 81/246 (32%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G + K++A+D DSG N +I Y
Sbjct: 446 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYL 504
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 505 LGPDA--PPE------------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF YNF V E +G + TD D+G N+ +T I
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 610
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 611 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 667
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 668 DNKPVF 673
Score = 77.8 bits (183), Expect = 3e-13
Identities = 157/658 (23%), Positives = 255/658 (38%), Gaps = 104/658 (15%)
Query: 770 IYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL 829
+ ++ IED NDN P+F I ENS I ++ + A D D G N + Y L
Sbjct: 122 LVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLP---AAVDPDVGINGVQNYEL 178
Query: 830 FGE----GKEMFDVDENTGVVKFI-GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIM 882
G ++ + E + + I LDRE+K Y + + D G SS A L +
Sbjct: 179 IKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVS 238
Query: 883 IGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPE 942
+ D NDN P F + E I N G ++ ++ A D D I E
Sbjct: 239 VTDTNDNHPVFKETE------IEVSIPENAPVGTSVTQL-----HATDAD-------IGE 280
Query: 943 NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRY-FVINERHGHV 1001
N I + +L S + ++ + N+ + K D E + ++ G +
Sbjct: 281 NAK-----IHFSFSNLVSNIARRL-FHLNATTGLITIKEPLDREETPNHKLLVLASDGGL 334
Query: 1002 IVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTR 1061
+ AR++ + ++ D + +I +R V VND + + N T+
Sbjct: 335 MPARAM-------VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLN--------TK 379
Query: 1062 RVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETEDKYIL 1118
L V DAD N +T F +D ++PF + P+ +L LD E+ +Y +
Sbjct: 380 IALITVTDKDAD--HNGRVTCF---TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAI 434
Query: 1119 TVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMM 1178
++A D G D NDN+P F + PE + + M
Sbjct: 435 KLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPENNSPGIQLTKVSAM 491
Query: 1179 IPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL--------GLP 1230
+ N +G F+ D G ++ L + K + L G+P
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLD---CRTGMLTVVKKLDREKEDKYLFTILAKDNGVP 548
Query: 1231 SLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVSLNLTEHYENF 1288
L+S + V++ D D + PVF Y + EN+ + V L+++ ++ +N
Sbjct: 549 PLTSNVTVFVSIIDQND-----NSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNS 603
Query: 1289 KMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMI 1348
+ IL+END F ID + G + S DRE +++Y V+
Sbjct: 604 AVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK-------------- 644
Query: 1349 YPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAPFGYQVMQL 1404
AED KV + + DVNDN P F N +P+T P G V Q+
Sbjct: 645 ---AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP-GTVVFQV 698
Score = 77.4 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 488 VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE-----DKYLFTIL 541
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + YN + ENLP +V + TD D G+
Sbjct: 542 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 601
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 602 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 647
Score = 76.2 bits (179), Expect = 9e-13
Identities = 52/178 (29%), Positives = 91/178 (51%), Gaps = 21/178 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A+D D+G+ YELI + +F LD + L ++KELD + + +T+
Sbjct: 163 AVDPDVGINGVQNYELIKSQN--IFGLDVIETPEGDKMPQLIVQKELDRE-----EKDTY 215
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V++V+ P +++ A +++ + D NDN P F+ +SI EN P G SV Q+ ATD
Sbjct: 216 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 275
Query: 333 KDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D GEN + + + + F ++ +G +T++ LDRE + ++ V A +
Sbjct: 276 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP--LDREETPNHKLLVLASD 331
Score = 67.7 bits (158), Expect = 3e-10
Identities = 82/341 (24%), Positives = 143/341 (41%), Gaps = 47/341 (13%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTV 134
++I + + IED+NDN P+F T ++++ E + K L A + P + I
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK--YTLPAAVDPDVGI--NG 172
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR-KVLDYDAG 193
+ + K F D TP D ++ + L+ K +++ KV D
Sbjct: 173 VQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE-----LDREEKDTYVMKVKVEDGGFP 227
Query: 194 DKEFQLVIMASG----------KRIHKEILFPE---------PIHAIDQDLGVGATLRYE 234
+ ++ S K E+ PE +HA D D+G A + +
Sbjct: 228 QRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFS 287
Query: 235 ---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQAR 291
L+S R+LF L++ G + +++ LD + N + L V AS + L A+A
Sbjct: 288 FSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----LLVLAS--DGGLMPARAM 340
Query: 292 VEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN+P ++ + N ++V EN+P + + TDKD NG T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-F 399
Query: 346 DDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D + F + P S + LD E+ +K+ A +
Sbjct: 400 TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAAD 440
Score = 64.1 bits (149), Expect = 4e-09
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 413 SNQFLLETAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 469
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G + +V A D D G N + Y L D FS+D R+G LTV +
Sbjct: 470 FVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-- 527
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 528 LDREKEDKYLFTILAKD 544
Score = 63.3 bits (147), Expect = 6e-09
Identities = 103/485 (21%), Positives = 185/485 (38%), Gaps = 50/485 (10%)
Query: 940 IPENIPIGTTIIKLN-ALDLDSGLNGQIRYEFNSEVY-IPPSKLSADALEVKRYFVINER 997
+PEN+ IG + LN +L + L ++++ + +P ++ D E+ F R
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEI---FTTGAR 90
Query: 998 HGHVIVARSLPPESEFRLNIS-ALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ +P + + A+ + + +R ++D+ND+ P+F T N ++ E
Sbjct: 91 IDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPE 150
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGELDRE 1111
A D D G N Y + S ++ L V ELDRE
Sbjct: 151 NSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE 210
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
+D Y++ V D G D NDN P F + +E PE +
Sbjct: 211 EKDTYVMKVKVEDGG-FPQRSSTAILQVSVTDTNDNHPVFKETE--IEVSIPENAPVGT- 266
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLP----QRKNQ 1224
SV + A I ENA I + + + +N + + N GLI P + N
Sbjct: 267 ---SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 1225 QNLGLPS----LSSTAILMVTVADVPDEVEMSDKPVFISRYYE-LEIEENVNAPVELVSL 1279
+ L L S + + A+++V V DV D V D ++ + + + EN+ ++ +
Sbjct: 324 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 383
Query: 1280 NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQK 1339
+T+ + R +++ R R V ++ A
Sbjct: 384 TVTDKDADHNGRVTCFTDHEIPFRL------------------RPVFSNQFLLETAAYLD 425
Query: 1340 YSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGY 1399
Y + I +A D + + +++KD NDN+P FT + +IP G
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF--VTVSIPENNSPGI 483
Query: 1400 QVMQL 1404
Q+ ++
Sbjct: 484 QLTKV 488
Score = 58.4 bits (135), Expect = 2e-07
Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 644
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V N S LP+ G V QV+A D D
Sbjct: 645 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDND 704
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 705 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 750
Score = 52.8 bits (121), Expect = 9e-06
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ PSN YE + S GTV+ +V AVD D G N V Y
Sbjct: 655 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 714 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 768
Query: 556 TIEV 559
+ V
Sbjct: 769 NLFV 772
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/206 (24%), Positives = 93/206 (45%), Gaps = 27/206 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSLTI 130
G+ +++ ++V V I D NDN P+F Y+ V E P G I + P G + +
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 605
Query: 131 PL---------TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L T+ + + +FDR+K + + V D G + SS K
Sbjct: 606 TLSILDENDDFTIDSQTGVIRPNISFDREKQES-----YTFYVKAEDGGRVSRSSSAKVT 660
Query: 182 LLLRKVLD------YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
+ + V D + ++LV+ ++ ++F + A+D D G+ A +RY +
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT---VVFQ--VIAVDNDTGMNAEVRYSI 715
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDL 261
+ GN R LF++D G++ L ++ D+
Sbjct: 716 VGGNTRDLFAIDQETGNITLMEKCDV 741
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/114 (29%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS--LTIPLTVPRGLT 139
S T Y++ D + + VT++ + K +F++ P S L +P T P G
Sbjct: 638 SYTFYVK-AEDGGRVSRSSSAKVTINVVDVNDNKP-VFIVPPSNCSYELVLPSTNP-GTV 694
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 695 VFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 745
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
LT A D+D G NA I Y + + P F++D +G + VV L R+
Sbjct: 485 LTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Score = 33.1 bits (72), Expect = 7.9
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G Q S+ + V + D NDN P+F +T V++ E P G
Sbjct: 225 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVG 265
>AL772287-1|CAI13625.2| 1066|Homo sapiens cadherin-like 23 protein.
Length = 1066
Score = 135 bits (327), Expect = 1e-30
Identities = 215/803 (26%), Positives = 315/803 (39%), Gaps = 128/803 (15%)
Query: 403 WRRQPLETNAPLEKTT-YVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVF-- 459
W RQPL+ E T + D G T VN++V D NDN P F
Sbjct: 88 WLRQPLDRETKSEFTVEFSVSDHQGVITRK-----------VNIQVG--DVNDNAPTFHN 134
Query: 460 --VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNT 517
+ E N VGT I V A DPDLG G VLY Q S F I+
Sbjct: 135 QPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF-----FAIDSAR 189
Query: 518 GTVSVAESPILEGRHA--LFVEASDQP-ANPSERRYSLAVVTIEVTRGTKGNKPDIPDFM 574
G V+V E A L V A+DQ P +LA++ +V + P F+
Sbjct: 190 GIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV-------QDMDPIFI 242
Query: 575 GAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLH--GYEEGVPFAVEERSGVIT 630
PY + + GT+V I D + Y ++ G + FA++ SGV+T
Sbjct: 243 NLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNTNSI-FALDYISGVLT 301
Query: 631 VVDDLSRYNRPMYDFEAVALQENANLS---------IVTNATVHVVDVNDERGVLLKGAH 681
+ L R N P+Y + + L+ + T + V+D+ND +
Sbjct: 302 LNGLLDREN-PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEY 360
Query: 682 SPIIFHVKENSAGAAIG-QIFH-----TNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED 735
S I + + + Q+ +M +Y G + F+I+ + D
Sbjct: 361 SVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSHHFIIS-----PTSVQGKAD 415
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
I PLD E D Y + A N+ V G +V I + +ENDN P+F Y
Sbjct: 416 IRIRVAIPLDYETVDRYDFDLFA--NESVPDHVGYAKVKITLINENDNRPIFSQPLYNIS 473
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
+ EN +GT + + ATD D GT FGE V F D DR
Sbjct: 474 LYENVTVGTSVLT---VLATDNDAGT--------FGE------------VSYFFSDDPDR 510
Query: 856 EKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAG 915
+ L +DTG LI++I + ++ I+ + I R+ T G
Sbjct: 511 -----FSLD---KDTG-------LIMLIA-----RLDYELIQRFTLTIIARDGGGEETTG 550
Query: 916 FTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVY 975
I V N + + + EN P T +++L A D DS N QI Y
Sbjct: 551 RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITY------- 603
Query: 976 IPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE------FRLNISALDGGN--LND 1027
S +SA A YF I+ G+ +++ S P + E L + A+D GN LN
Sbjct: 604 ---SIVSASAFG--SYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNS 658
Query: 1028 NISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
+ V + V D ND+ P F K Y +V E + ++ATD D + I
Sbjct: 659 TVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL 718
Query: 1088 DTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG-XXXXXXXXXXXXXXXXDVND 1146
+ F I+ +G ++ LDRET+ +YIL V A D G D+ND
Sbjct: 719 EGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIND 778
Query: 1147 NSPKFY---AFDELLEWKHPEAD 1166
N P + + L+E P++D
Sbjct: 779 NHPTWKDAPYYINLVEMTPPDSD 801
Score = 101 bits (241), Expect = 3e-20
Identities = 175/724 (24%), Positives = 284/724 (39%), Gaps = 83/724 (11%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGK-VKAVDPDLGQNGMV-LYDLQRTSN 504
+ ++D NDN P F S Y ++ A+VG + ++ VD D G N M +Y + S+
Sbjct: 343 ILVIDINDNAPEFNSSE-YSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSH 401
Query: 505 LTITSPFKINPNTGT-VSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRGT 563
I SP + + VA E + + P Y+ +T+
Sbjct: 402 HFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDN 461
Query: 564 KGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVPFA 621
+ P F Y + NV +GTSV + NDA +VSY + F+
Sbjct: 462 R------PIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR---FS 512
Query: 622 VEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAH 681
+++ +G+I ++ L + +A ++ ++V+DVND K A+
Sbjct: 513 LDKDTGLIMLIARLDYELIQRFTLTIIA-RDGGGEETTGRVRINVLDVNDNVPTFQKDAY 571
Query: 682 SPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTD--DIAIAED-GTI 738
+ ++EN ++ Q+ + + + I + DI++ E G I
Sbjct: 572 ---VGALRENEP--SVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVI 626
Query: 739 FTQKPLDREK--RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFI 796
+PLD E+ + +TV+A + G VTI + DENDNPP F Y +
Sbjct: 627 SVSRPLDYEQISNGLIYLTVMA-MDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSV 685
Query: 797 MENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE 856
+EN G + N + E +Y+L EG F ++ +G + LDRE
Sbjct: 686 VENIMAGATVLFLNATDLDRSREYGQESIIYSL--EGSTQFRINARSGEITTTS-LLDRE 742
Query: 857 KKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGF 916
K SE LI+ D + N K I T
Sbjct: 743 TK----------------SEYILIVRAVDGG--------VGHNQKTGI-------ATVNI 771
Query: 917 TIIEVKPKNKFALDVDQLGPLFL-IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVY 975
T++++ + D P ++ + E P + + + A+D D G NG + Y
Sbjct: 772 TLLDINDNHPTWKDA----PYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ---- 823
Query: 976 IPPSKL-SADALEVKRYFVINERHGHVIVARSLPPESEF--RLNISALDGGN--LNDNIS 1030
PP+K S ++ K I H + P E+E ++ +S D G L S
Sbjct: 824 -PPNKFYSLNSTTGK----IRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSS 878
Query: 1031 VRVFVK--DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
VFV D+ND+ P F+ + V E + +V A D D G N ++Y +
Sbjct: 879 ATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGM 938
Query: 1089 TDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
+ F I+ +GV+ ELDRE +Y L VVA D G DVND +
Sbjct: 939 PRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAG-TPTKSSTSTLTIHVLDVNDET 997
Query: 1149 PKFY 1152
P F+
Sbjct: 998 PTFF 1001
Score = 99.1 bits (236), Expect = 1e-19
Identities = 183/777 (23%), Positives = 305/777 (39%), Gaps = 88/777 (11%)
Query: 582 VGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRP 641
+ + +G+SV Q+ D ND + G E FAVE +GV+ + L R +
Sbjct: 42 ISEDTPVGSSVTQLLAQDM--DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKS 99
Query: 642 MYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIF 701
+ E ++ ++ + I + V DVND +S I V IF
Sbjct: 100 EFTVE-FSVSDHQGV-ITRKVNIQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIF 157
Query: 702 HTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEF 760
N + G+V + Q + AI + G + + LD E Y++TV A
Sbjct: 158 IVNATDPDLGAGGSVLYSF---QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATD 214
Query: 761 NKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEG 820
+ + + I I D D P+F + Y I E+S GT ++ II A D D+G
Sbjct: 215 QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR---IITAIDQDKG 271
Query: 821 TNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELI 880
YT+ V NT + +LD ++ L+ R+ L S ++
Sbjct: 272 RPRGIGYTIVS-------VAGNTNSIF----ALDYISGVLTLNGLLDRENP-LYSHGFIL 319
Query: 881 IMIGDE-NDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFL 939
+ G E ND+ R + + T +I++ N A + +
Sbjct: 320 TVKGTELNDD-------------RTPSDATVTTTFNILVIDI---NDNAPEFNSSEYSVA 363
Query: 940 IPENIPIGTTI-IKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERH 998
I E +G + + + +D D GLN EVY+ + ++ + V +
Sbjct: 364 ITELAQVGFALPLFIQVVDKDEGLNSMF------EVYLVGN--NSHHFIISPTSVQGKAD 415
Query: 999 GHVIVARSLPPESEFRLNISALDGGNLNDNIS---VRVFVKDVNDHFPVFKKTWYNFNVE 1055
+ VA L E+ R + ++ D++ V++ + + ND+ P+F + YN ++
Sbjct: 416 IRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLY 475
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E + V ATD D G ++YF SD F + TG++ + LD E +
Sbjct: 476 ENVTVGTSVLTVLATDNDAGTFGEVSYFF--SDDPDRFSLDKDTGLIMLIARLDYELIQR 533
Query: 1116 YILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY--AFDELLEWKHPEADEL----- 1168
+ LT++ARD G DVNDN P F A+ L P +L
Sbjct: 534 FTLTIIARDGG---GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRA 590
Query: 1169 -------SNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQR 1221
+N S++ + + + + G V V + D+ NGLI ++
Sbjct: 591 TDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISV-SRPLDYEQISNGLIYLTV--- 646
Query: 1222 KNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL 1281
+ G P L+ST + + V D E + P F Y + + EN+ A ++ LN
Sbjct: 647 -MAMDAGNPPLNSTVPVTIEVFD-----ENDNPPTFSKPAYFVSVVENIMAGATVLFLNA 700
Query: 1282 T--EHYENFKMRYYILN-ENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
T + + I + E T R I+ R+G + DRE K Y +IVRA
Sbjct: 701 TDLDRSREYGQESIIYSLEGSTQFR----INARSGEITTTSLLDRETKSEYILIVRA 753
Score = 96.7 bits (230), Expect = 6e-19
Identities = 79/287 (27%), Positives = 135/287 (47%), Gaps = 20/287 (6%)
Query: 71 GAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSL 128
G G NQ + +V + + D+NDN P + D PY++ + E+TP + + + P +G +
Sbjct: 757 GVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENG 816
Query: 129 TIPLTVPRGLTIFK------DIRA----FDRDKPNTPNSDVHYSIV-SGNDDGHFALESS 177
T+ ++ + IR DR+ P+ +++ IV S D G L+++
Sbjct: 817 TLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKAT 876
Query: 178 HKPVLLLRKVLDYDAGDKEFQ-LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELI 236
+ + +LD + D FQ L +A + + AID D G+ + Y +
Sbjct: 877 SSATVFVN-LLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP 935
Query: 237 SGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
G R F ++S +G + ELD + Q L+V AS P K++ + + I +
Sbjct: 936 VGMPRMDFLINSSSGVVVTTTELDRERIAEYQ-----LRVVASDAGTPTKSSTSTLTIHV 990
Query: 297 LDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTY 343
LD+ND P F YN+S+ E++P F V+ + TD D G N E +Y
Sbjct: 991 LDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSY 1037
Score = 95.5 bits (227), Expect = 1e-18
Identities = 131/529 (24%), Positives = 221/529 (41%), Gaps = 58/529 (10%)
Query: 440 MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
+ + V++TL++ NDN P+F LY S+ N VGT + V A D D G G V Y
Sbjct: 446 VGYAKVKITLINENDNRPIF-SQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF 504
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTI 557
+ F ++ +TG + + E R L + A D + R + V+ +
Sbjct: 505 SDDPDR-----FSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDV 559
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGYE 615
++P F Y + N T + ++R D N ++Y ++
Sbjct: 560 N---------DNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASA 610
Query: 616 EGVPFAVE--ERSGVITVVD--DLSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVDVN 670
G F + E GVI+V D + + + +A+ N L+ T+ V D N
Sbjct: 611 FGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDEN 670
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
D K A+ + V+ AGA + + T++ G ++ I + + T
Sbjct: 671 DNPPTFSKPAY--FVSVVENIMAGATVLFLNATDLDRSREYGQESI---IYSLEGSTQFR 725
Query: 731 AIAEDGTIFTQKPLDREKRDVYRMTVIA-EFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
A G I T LDRE + Y + V A + G GI V I + D NDN P ++
Sbjct: 726 INARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKD 785
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFI 849
A Y ++E + +++ + A D D G N +Y++ K + ++ TG ++
Sbjct: 786 APYYINLVEMTPPDSDV---TTVVAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTT 841
Query: 850 GDSLDREK------KIMYKLSLVARDTG----GLSSEAELIIMIGDENDNKPEFNQIEEN 899
LDRE ++M K+ + D G +S A + + + D NDN P F +
Sbjct: 842 HAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFV 901
Query: 900 SKVRIHRETKLNG-TAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIG 947
++V L G AG +I +V A+D+D+ G L+ +P+G
Sbjct: 902 AEV-------LEGIPAGVSIYQV-----VAIDLDE-GLNGLVSYRMPVG 937
Score = 89.8 bits (213), Expect = 6e-17
Identities = 91/332 (27%), Positives = 145/332 (43%), Gaps = 24/332 (7%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF---IFLIAPIGPSLTIPLTVPRGLT 139
V + + DVNDN P F + PY V + E+ TG IF++ P L +V
Sbjct: 118 VNIQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQ 177
Query: 140 IFKDIRAFDRDKPN-TPNSDVHYSIVSGNDDGHFALESSH-KPVLLLRK--VLDYDAGDK 195
A D + T ++ Y A + +P+ L ++ D D
Sbjct: 178 PPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDM 237
Query: 196 EFQLVIMASGKRIHKEI---LFPEPIHAIDQDLGVGATLRYELIS--GNDRKLFSLDSVN 250
+ + + I++ I AIDQD G + Y ++S GN +F+LD ++
Sbjct: 238 DPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNTNSIFALDYIS 297
Query: 251 GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV----EIELLDLNDNLPEF 306
G L L LD E+ L ++ F+L V+ ++LN+ + A V I ++D+NDN PEF
Sbjct: 298 GVLTLNGLLD--RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEF 355
Query: 307 EVDFYNISIVENLPNGFSV-LQVMATDKDQGENGEF-TYQLDDPKGAFSIDPRS----GW 360
Y+++I E GF++ L + DKD+G N F Y + + F I P S
Sbjct: 356 NSSEYSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSHHFIISPTSVQGKAD 415
Query: 361 LTVRNQTVLDREAHSSLRMKVYAKETNPSVVG 392
+ +R LD E ++A E+ P VG
Sbjct: 416 IRIRVAIPLDYETVDRYDFDLFANESVPDHVG 447
Score = 86.6 bits (205), Expect = 6e-16
Identities = 107/407 (26%), Positives = 162/407 (39%), Gaps = 45/407 (11%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN T TI EV +N + + ENI G T++ LNA DLD Y
Sbjct: 656 LNSTVPVTI-EVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSR----EYG 710
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG---N 1024
S +Y +LE F IN R G + L E SE+ L + A+DGG N
Sbjct: 711 QESIIY---------SLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHN 761
Query: 1025 LNDNI-SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYF 1083
I +V + + D+ND+ P +K Y N+ E + V A D D G+N L Y
Sbjct: 762 QKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS 821
Query: 1084 IQPSDTDLPFEISPLTG-VLSVNGELDRETEDKY------ILTVVARDNGX-XXXXXXXX 1135
IQP + + ++ TG + + + LDRE D + + V D G
Sbjct: 822 IQPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 879
Query: 1136 XXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTT 1195
D+NDN P F + E +S + ++ + + P+G
Sbjct: 880 TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMP 939
Query: 1196 VAKVFANDTDFIG------NGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEV 1249
N + + + + Y L R + G P+ SST+ L + V DV DE
Sbjct: 940 RMDFLINSSSGVVVTTTELDRERIAEYQL--RVVASDAGTPTKSSTSTLTIHVLDVNDET 997
Query: 1250 EMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYI 1294
P F Y + + E+V +V LN T++ N ++ Y+I
Sbjct: 998 -----PTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFI 1039
Score = 76.6 bits (180), Expect = 6e-13
Identities = 60/174 (34%), Positives = 88/174 (50%), Gaps = 14/174 (8%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSL-----FLEKELDLDAEHNLQANTFVL 274
A+D DLG TL Y + N K +SL+S G + L++E E L V
Sbjct: 807 AVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVS 864
Query: 275 QVQASQLNNPLK-TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
+ PLK T+ A V + LLDLNDN P F+ + ++E +P G S+ QV+A D
Sbjct: 865 VTDCGR--PPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDL 922
Query: 334 DQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D+G NG +Y++ P+ F I+ SG V T LDRE + +++V A +
Sbjct: 923 DEGLNGLVSYRMPVGMPRMDFLINSSSG--VVVTTTELDRERIAEYQLRVVASD 974
Score = 76.2 bits (179), Expect = 9e-13
Identities = 81/326 (24%), Positives = 133/326 (40%), Gaps = 21/326 (6%)
Query: 77 ISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIA------PIGPSLTI 130
+S ++ + I DV D PIF++ PY + E +P G I P G TI
Sbjct: 221 LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI 280
Query: 131 PLTVPRGLTIF-----KDIRAFDR--DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLL 183
+IF + + D+ N S V G + S
Sbjct: 281 VSVAGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTT 340
Query: 184 LR-KVLDYDAGDKEFQLVIMASGKRIHKEILFPEP--IHAIDQDLGVGATLRYELISGND 240
V+D + EF + ++ F P I +D+D G+ + L+ N
Sbjct: 341 FNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNS 400
Query: 241 RK-LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
+ S SV G + + + ++ + + + A++ + P A+V+I L++
Sbjct: 401 HHFIISPTSVQGKADIRIRVAIPLDYET-VDRYDFDLFANE-SVPDHVGYAKVKITLINE 458
Query: 300 NDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSG 359
NDN P F YNIS+ EN+ G SVL V+ATD D G GE +Y D FS+D +G
Sbjct: 459 NDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTG 518
Query: 360 WLTVRNQTVLDREAHSSLRMKVYAKE 385
+ + + LD E + + A++
Sbjct: 519 LIMLIAR--LDYELIQRFTLTIIARD 542
Score = 68.9 bits (161), Expect = 1e-10
Identities = 68/247 (27%), Positives = 102/247 (41%), Gaps = 24/247 (9%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
Q V +TLLD NDN+P + + Y ++ + + V AVDPDLG+NG ++Y
Sbjct: 762 QKTGIATVNITLLDINDNHPTWKDAPYY-INLVEMTPPDSDVTTVVAVDPDLGENGTLVY 820
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVA------ESP---ILEGRHALFVEASDQPANPSER 548
+Q + + +N TG + E+P E + V +D P +
Sbjct: 821 SIQPPNKF-----YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTD-CGRPPLK 874
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDV 606
S A V + + N D P F P+ V + G S+ Q+ D E V
Sbjct: 875 ATSSATVFVNL---LDLNDND-PTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLV 930
Query: 607 SYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVH 665
SY + G + F + SGV+ +L R Y VA S + T+H
Sbjct: 931 SYRMPVGMPR-MDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIH 989
Query: 666 VVDVNDE 672
V+DVNDE
Sbjct: 990 VLDVNDE 996
Score = 62.9 bits (146), Expect = 9e-09
Identities = 53/170 (31%), Positives = 77/170 (45%), Gaps = 8/170 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGND-RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D+D + Y ++S + F + G + LD E + L V
Sbjct: 588 LRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ-ISNGLIYLTV 646
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A NP + V IE+ D NDN P F Y +S+VEN+ G +VL + ATD D+
Sbjct: 647 MAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRS 706
Query: 337 -ENGE--FTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
E G+ Y L+ F I+ RSG +T ++LDRE S + V A
Sbjct: 707 REYGQESIIYSLEG-STQFRINARSGEIT--TTSLLDRETKSEYILIVRA 753
Score = 62.1 bits (144), Expect = 1e-08
Identities = 72/264 (27%), Positives = 121/264 (45%), Gaps = 38/264 (14%)
Query: 144 IRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKP--VLLLRKVLDYDA-GDKEFQLV 200
+RA D D P PN+ + YSIVS + G + S ++ V+ + + LDY+ + L
Sbjct: 588 LRATDEDSP--PNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLT 645
Query: 201 IMA---------SGKRIHKEIL--------FPEPIHAID--QDLGVGATLRYELISGNDR 241
+MA S + E+ F +P + + +++ GAT+ + + DR
Sbjct: 646 VMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDR 705
Query: 242 -KLFSLDSVNGSLFLEKELDLDAEHNLQANT----------FVLQVQASQ--LNNPLKTA 288
+ + +S+ SL + ++A T ++L V+A + + KT
Sbjct: 706 SREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTG 765
Query: 289 QARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDP 348
A V I LLD+NDN P ++ Y I++VE P V V+A D D GENG Y + P
Sbjct: 766 IATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP 825
Query: 349 KGAFSIDPRSGWLTVRNQTVLDRE 372
+S++ +G + +LDRE
Sbjct: 826 NKFYSLNSTTGKIRT-THAMLDRE 848
Score = 58.4 bits (135), Expect = 2e-07
Identities = 41/126 (32%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D G + Y DR FSLD G + L LD + F L + A
Sbjct: 489 ATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYEL-----IQRFTLTIIAR 541
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
T RV I +LD+NDN+P F+ D Y ++ EN P+ ++++ ATD+D N
Sbjct: 542 DGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNN 599
Query: 340 EFTYQL 345
+ TY +
Sbjct: 600 QITYSI 605
Score = 54.0 bits (124), Expect = 4e-06
Identities = 43/156 (27%), Positives = 72/156 (46%), Gaps = 16/156 (10%)
Query: 236 ISGNDR-KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
+SG + + F+++ G ++L + LD + + + F ++ S + +V I
Sbjct: 69 VSGEEASRFFAVEPDTGVVWLRQPLDRETK-----SEFTVEFSVSDHQGVITR---KVNI 120
Query: 295 ELLDLNDNLPEFEVDFYNISIVE-----NLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
++ D+NDN P F Y++ I E N P G + V ATD D G G Y P
Sbjct: 121 QVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS 180
Query: 350 GAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
F+ID G +TV + LD E + ++ V A +
Sbjct: 181 QFFAIDSARGIVTVIRE--LDYETTQAYQLTVNATD 214
Score = 52.8 bits (121), Expect = 9e-06
Identities = 99/413 (23%), Positives = 170/413 (41%), Gaps = 47/413 (11%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPD----LGQNGM 494
L S V V + + D NDN P F Y S+ N G + + A D D GQ
Sbjct: 656 LNSTVPVTIEVFDENDNPPTF-SKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQES- 713
Query: 495 VLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSL 552
++Y L+ ++ F+IN +G ++ E + + L V A D +++
Sbjct: 714 IIYSLEGSTQ------FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKT--- 764
Query: 553 AVVTIEVTR-GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQI-RVNDAFEQNDVSYDL 610
+ T+ +T N P D APY + + V + V+ +N L
Sbjct: 765 GIATVNITLLDINDNHPTWKD---APYYINLVEMTPPDSDVTTVVAVDPDLGENGT---L 818
Query: 611 LHGYEEGVPF-AVEERSGVI-TVVDDLSRYNRPMYDFE-----AVALQENAN--LSIVTN 661
++ + F ++ +G I T L R N ++ E V++ + L ++
Sbjct: 819 VYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSS 878
Query: 662 ATVHV--VDVNDERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRF 718
ATV V +D+ND + P + V E AG +I Q+ ++ NG + R
Sbjct: 879 ATVFVNLLDLNDNDPTF---QNLPFVAEVLEGIPAGVSIYQVVAIDLDEGL-NGLVSYRM 934
Query: 719 LIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIE 778
+ + D + + G + T LDRE+ Y++ V+A + G + + +TI++
Sbjct: 935 PVGMPR--MDFLINSSSGVVVTTTELDRERIAEYQLRVVAS-DAGTPTKSSTSTLTIHVL 991
Query: 779 DENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG 831
D ND P F A Y + E+ + E ++ + TD D G NA Y + G
Sbjct: 992 DVNDETPTFFPAVYNVSVSED--VPREFRV-VWLNCTDNDVGLNAELSYFITG 1041
Score = 44.0 bits (99), Expect = 0.004
Identities = 60/250 (24%), Positives = 103/250 (41%), Gaps = 36/250 (14%)
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTDFIGN-GNGLILYSLP-QRKNQQNLGLPSLSSTAI 1237
P Y ++ EN G TV + A D D G I+YSL + + N +++T++
Sbjct: 679 PAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSL 738
Query: 1238 LMVTVADVPDEVEMSDKPVFISRYYELEIEENVN---APVELVSLNLTEHYENFK-MRYY 1293
L + E + + I R + + N A V + L++ +++ +K YY
Sbjct: 739 L---------DRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYY 789
Query: 1294 I----LNENDTDIRRTFVIDP---RNGTL-YLVRSPDR---------EVKDTYEVIVRAE 1336
I + D+D+ +DP NGTL Y ++ P++ +++ T+ ++ R
Sbjct: 790 INLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDREN 849
Query: 1337 RQKYSRELPHMIYPVAEDVLEGMTKY--DVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTT 1394
+ EL I D K V V + D+NDN P F N P V +
Sbjct: 850 PDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ--NLPFVAEVLEG 907
Query: 1395 APFGYQVMQL 1404
P G + Q+
Sbjct: 908 IPAGVSIYQV 917
Score = 33.5 bits (73), Expect = 6.0
Identities = 16/45 (35%), Positives = 25/45 (55%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTP 111
+V AG S+ ++T+++ DVND P F Y+V+V E P
Sbjct: 970 VVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVP 1014
>AL731541-5|CAM20296.1| 1066|Homo sapiens cadherin-like 23 protein.
Length = 1066
Score = 135 bits (327), Expect = 1e-30
Identities = 215/803 (26%), Positives = 315/803 (39%), Gaps = 128/803 (15%)
Query: 403 WRRQPLETNAPLEKTT-YVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVF-- 459
W RQPL+ E T + D G T VN++V D NDN P F
Sbjct: 88 WLRQPLDRETKSEFTVEFSVSDHQGVITRK-----------VNIQVG--DVNDNAPTFHN 134
Query: 460 --VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNT 517
+ E N VGT I V A DPDLG G VLY Q S F I+
Sbjct: 135 QPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF-----FAIDSAR 189
Query: 518 GTVSVAESPILEGRHA--LFVEASDQP-ANPSERRYSLAVVTIEVTRGTKGNKPDIPDFM 574
G V+V E A L V A+DQ P +LA++ +V + P F+
Sbjct: 190 GIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV-------QDMDPIFI 242
Query: 575 GAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLH--GYEEGVPFAVEERSGVIT 630
PY + + GT+V I D + Y ++ G + FA++ SGV+T
Sbjct: 243 NLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNTNSI-FALDYISGVLT 301
Query: 631 VVDDLSRYNRPMYDFEAVALQENANLS---------IVTNATVHVVDVNDERGVLLKGAH 681
+ L R N P+Y + + L+ + T + V+D+ND +
Sbjct: 302 LNGLLDREN-PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEY 360
Query: 682 SPIIFHVKENSAGAAIG-QIFH-----TNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED 735
S I + + + Q+ +M +Y G + F+I+ + D
Sbjct: 361 SVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSHHFIIS-----PTSVQGKAD 415
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
I PLD E D Y + A N+ V G +V I + +ENDN P+F Y
Sbjct: 416 IRIRVAIPLDYETVDRYDFDLFA--NESVPDHVGYAKVKITLINENDNRPIFSQPLYNIS 473
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
+ EN +GT + + ATD D GT FGE V F D DR
Sbjct: 474 LYENVTVGTSVLT---VLATDNDAGT--------FGE------------VSYFFSDDPDR 510
Query: 856 EKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAG 915
+ L +DTG LI++I + ++ I+ + I R+ T G
Sbjct: 511 -----FSLD---KDTG-------LIMLIA-----RLDYELIQRFTLTIIARDGGGEETTG 550
Query: 916 FTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVY 975
I V N + + + EN P T +++L A D DS N QI Y
Sbjct: 551 RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITY------- 603
Query: 976 IPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE------FRLNISALDGGN--LND 1027
S +SA A YF I+ G+ +++ S P + E L + A+D GN LN
Sbjct: 604 ---SIVSASAFG--SYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNS 658
Query: 1028 NISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
+ V + V D ND+ P F K Y +V E + ++ATD D + I
Sbjct: 659 TVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL 718
Query: 1088 DTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG-XXXXXXXXXXXXXXXXDVND 1146
+ F I+ +G ++ LDRET+ +YIL V A D G D+ND
Sbjct: 719 EGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIND 778
Query: 1147 NSPKFY---AFDELLEWKHPEAD 1166
N P + + L+E P++D
Sbjct: 779 NHPTWKDAPYYINLVEMTPPDSD 801
Score = 101 bits (241), Expect = 3e-20
Identities = 175/724 (24%), Positives = 284/724 (39%), Gaps = 83/724 (11%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGK-VKAVDPDLGQNGMV-LYDLQRTSN 504
+ ++D NDN P F S Y ++ A+VG + ++ VD D G N M +Y + S+
Sbjct: 343 ILVIDINDNAPEFNSSE-YSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSH 401
Query: 505 LTITSPFKINPNTGT-VSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRGT 563
I SP + + VA E + + P Y+ +T+
Sbjct: 402 HFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDN 461
Query: 564 KGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVPFA 621
+ P F Y + NV +GTSV + NDA +VSY + F+
Sbjct: 462 R------PIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR---FS 512
Query: 622 VEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAH 681
+++ +G+I ++ L + +A ++ ++V+DVND K A+
Sbjct: 513 LDKDTGLIMLIARLDYELIQRFTLTIIA-RDGGGEETTGRVRINVLDVNDNVPTFQKDAY 571
Query: 682 SPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTD--DIAIAED-GTI 738
+ ++EN ++ Q+ + + + I + DI++ E G I
Sbjct: 572 ---VGALRENEP--SVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVI 626
Query: 739 FTQKPLDREK--RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFI 796
+PLD E+ + +TV+A + G VTI + DENDNPP F Y +
Sbjct: 627 SVSRPLDYEQISNGLIYLTVMA-MDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSV 685
Query: 797 MENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE 856
+EN G + N + E +Y+L EG F ++ +G + LDRE
Sbjct: 686 VENIMAGATVLFLNATDLDRSREYGQESIIYSL--EGSTQFRINARSGEITTTS-LLDRE 742
Query: 857 KKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGF 916
K SE LI+ D + N K I T
Sbjct: 743 TK----------------SEYILIVRAVDGG--------VGHNQKTGI-------ATVNI 771
Query: 917 TIIEVKPKNKFALDVDQLGPLFL-IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVY 975
T++++ + D P ++ + E P + + + A+D D G NG + Y
Sbjct: 772 TLLDINDNHPTWKDA----PYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ---- 823
Query: 976 IPPSKL-SADALEVKRYFVINERHGHVIVARSLPPESEF--RLNISALDGGN--LNDNIS 1030
PP+K S ++ K I H + P E+E ++ +S D G L S
Sbjct: 824 -PPNKFYSLNSTTGK----IRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSS 878
Query: 1031 VRVFVK--DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
VFV D+ND+ P F+ + V E + +V A D D G N ++Y +
Sbjct: 879 ATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGM 938
Query: 1089 TDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
+ F I+ +GV+ ELDRE +Y L VVA D G DVND +
Sbjct: 939 PRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAG-TPTKSSTSTLTIHVLDVNDET 997
Query: 1149 PKFY 1152
P F+
Sbjct: 998 PTFF 1001
Score = 99.1 bits (236), Expect = 1e-19
Identities = 183/777 (23%), Positives = 305/777 (39%), Gaps = 88/777 (11%)
Query: 582 VGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRP 641
+ + +G+SV Q+ D ND + G E FAVE +GV+ + L R +
Sbjct: 42 ISEDTPVGSSVTQLLAQDM--DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKS 99
Query: 642 MYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIF 701
+ E ++ ++ + I + V DVND +S I V IF
Sbjct: 100 EFTVE-FSVSDHQGV-ITRKVNIQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIF 157
Query: 702 HTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEF 760
N + G+V + Q + AI + G + + LD E Y++TV A
Sbjct: 158 IVNATDPDLGAGGSVLYSF---QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATD 214
Query: 761 NKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEG 820
+ + + I I D D P+F + Y I E+S GT ++ II A D D+G
Sbjct: 215 QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR---IITAIDQDKG 271
Query: 821 TNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELI 880
YT+ V NT + +LD ++ L+ R+ L S ++
Sbjct: 272 RPRGIGYTIVS-------VAGNTNSIF----ALDYISGVLTLNGLLDRENP-LYSHGFIL 319
Query: 881 IMIGDE-NDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFL 939
+ G E ND+ R + + T +I++ N A + +
Sbjct: 320 TVKGTELNDD-------------RTPSDATVTTTFNILVIDI---NDNAPEFNSSEYSVA 363
Query: 940 IPENIPIGTTI-IKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERH 998
I E +G + + + +D D GLN EVY+ + ++ + V +
Sbjct: 364 ITELAQVGFALPLFIQVVDKDEGLNSMF------EVYLVGN--NSHHFIISPTSVQGKAD 415
Query: 999 GHVIVARSLPPESEFRLNISALDGGNLNDNIS---VRVFVKDVNDHFPVFKKTWYNFNVE 1055
+ VA L E+ R + ++ D++ V++ + + ND+ P+F + YN ++
Sbjct: 416 IRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLY 475
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E + V ATD D G ++YF SD F + TG++ + LD E +
Sbjct: 476 ENVTVGTSVLTVLATDNDAGTFGEVSYFF--SDDPDRFSLDKDTGLIMLIARLDYELIQR 533
Query: 1116 YILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY--AFDELLEWKHPEADEL----- 1168
+ LT++ARD G DVNDN P F A+ L P +L
Sbjct: 534 FTLTIIARDGG---GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRA 590
Query: 1169 -------SNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQR 1221
+N S++ + + + + G V V + D+ NGLI ++
Sbjct: 591 TDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISV-SRPLDYEQISNGLIYLTV--- 646
Query: 1222 KNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL 1281
+ G P L+ST + + V D E + P F Y + + EN+ A ++ LN
Sbjct: 647 -MAMDAGNPPLNSTVPVTIEVFD-----ENDNPPTFSKPAYFVSVVENIMAGATVLFLNA 700
Query: 1282 T--EHYENFKMRYYILN-ENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
T + + I + E T R I+ R+G + DRE K Y +IVRA
Sbjct: 701 TDLDRSREYGQESIIYSLEGSTQFR----INARSGEITTTSLLDRETKSEYILIVRA 753
Score = 96.7 bits (230), Expect = 6e-19
Identities = 79/287 (27%), Positives = 135/287 (47%), Gaps = 20/287 (6%)
Query: 71 GAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSL 128
G G NQ + +V + + D+NDN P + D PY++ + E+TP + + + P +G +
Sbjct: 757 GVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENG 816
Query: 129 TIPLTVPRGLTIFK------DIRA----FDRDKPNTPNSDVHYSIV-SGNDDGHFALESS 177
T+ ++ + IR DR+ P+ +++ IV S D G L+++
Sbjct: 817 TLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKAT 876
Query: 178 HKPVLLLRKVLDYDAGDKEFQ-LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELI 236
+ + +LD + D FQ L +A + + AID D G+ + Y +
Sbjct: 877 SSATVFVN-LLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP 935
Query: 237 SGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
G R F ++S +G + ELD + Q L+V AS P K++ + + I +
Sbjct: 936 VGMPRMDFLINSSSGVVVTTTELDRERIAEYQ-----LRVVASDAGTPTKSSTSTLTIHV 990
Query: 297 LDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTY 343
LD+ND P F YN+S+ E++P F V+ + TD D G N E +Y
Sbjct: 991 LDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSY 1037
Score = 95.5 bits (227), Expect = 1e-18
Identities = 131/529 (24%), Positives = 221/529 (41%), Gaps = 58/529 (10%)
Query: 440 MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
+ + V++TL++ NDN P+F LY S+ N VGT + V A D D G G V Y
Sbjct: 446 VGYAKVKITLINENDNRPIF-SQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF 504
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTI 557
+ F ++ +TG + + E R L + A D + R + V+ +
Sbjct: 505 SDDPDR-----FSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDV 559
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGYE 615
++P F Y + N T + ++R D N ++Y ++
Sbjct: 560 N---------DNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASA 610
Query: 616 EGVPFAVE--ERSGVITVVD--DLSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVDVN 670
G F + E GVI+V D + + + +A+ N L+ T+ V D N
Sbjct: 611 FGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDEN 670
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
D K A+ + V+ AGA + + T++ G ++ I + + T
Sbjct: 671 DNPPTFSKPAY--FVSVVENIMAGATVLFLNATDLDRSREYGQESI---IYSLEGSTQFR 725
Query: 731 AIAEDGTIFTQKPLDREKRDVYRMTVIA-EFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
A G I T LDRE + Y + V A + G GI V I + D NDN P ++
Sbjct: 726 INARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKD 785
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFI 849
A Y ++E + +++ + A D D G N +Y++ K + ++ TG ++
Sbjct: 786 APYYINLVEMTPPDSDV---TTVVAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTT 841
Query: 850 GDSLDREK------KIMYKLSLVARDTG----GLSSEAELIIMIGDENDNKPEFNQIEEN 899
LDRE ++M K+ + D G +S A + + + D NDN P F +
Sbjct: 842 HAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFV 901
Query: 900 SKVRIHRETKLNG-TAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIG 947
++V L G AG +I +V A+D+D+ G L+ +P+G
Sbjct: 902 AEV-------LEGIPAGVSIYQV-----VAIDLDE-GLNGLVSYRMPVG 937
Score = 89.8 bits (213), Expect = 6e-17
Identities = 91/332 (27%), Positives = 145/332 (43%), Gaps = 24/332 (7%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF---IFLIAPIGPSLTIPLTVPRGLT 139
V + + DVNDN P F + PY V + E+ TG IF++ P L +V
Sbjct: 118 VNIQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQ 177
Query: 140 IFKDIRAFDRDKPN-TPNSDVHYSIVSGNDDGHFALESSH-KPVLLLRK--VLDYDAGDK 195
A D + T ++ Y A + +P+ L ++ D D
Sbjct: 178 PPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDM 237
Query: 196 EFQLVIMASGKRIHKEI---LFPEPIHAIDQDLGVGATLRYELIS--GNDRKLFSLDSVN 250
+ + + I++ I AIDQD G + Y ++S GN +F+LD ++
Sbjct: 238 DPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNTNSIFALDYIS 297
Query: 251 GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV----EIELLDLNDNLPEF 306
G L L LD E+ L ++ F+L V+ ++LN+ + A V I ++D+NDN PEF
Sbjct: 298 GVLTLNGLLD--RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEF 355
Query: 307 EVDFYNISIVENLPNGFSV-LQVMATDKDQGENGEF-TYQLDDPKGAFSIDPRS----GW 360
Y+++I E GF++ L + DKD+G N F Y + + F I P S
Sbjct: 356 NSSEYSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSHHFIISPTSVQGKAD 415
Query: 361 LTVRNQTVLDREAHSSLRMKVYAKETNPSVVG 392
+ +R LD E ++A E+ P VG
Sbjct: 416 IRIRVAIPLDYETVDRYDFDLFANESVPDHVG 447
Score = 86.6 bits (205), Expect = 6e-16
Identities = 107/407 (26%), Positives = 162/407 (39%), Gaps = 45/407 (11%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN T TI EV +N + + ENI G T++ LNA DLD Y
Sbjct: 656 LNSTVPVTI-EVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSR----EYG 710
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG---N 1024
S +Y +LE F IN R G + L E SE+ L + A+DGG N
Sbjct: 711 QESIIY---------SLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHN 761
Query: 1025 LNDNI-SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYF 1083
I +V + + D+ND+ P +K Y N+ E + V A D D G+N L Y
Sbjct: 762 QKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS 821
Query: 1084 IQPSDTDLPFEISPLTG-VLSVNGELDRETEDKY------ILTVVARDNGX-XXXXXXXX 1135
IQP + + ++ TG + + + LDRE D + + V D G
Sbjct: 822 IQPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 879
Query: 1136 XXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTT 1195
D+NDN P F + E +S + ++ + + P+G
Sbjct: 880 TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMP 939
Query: 1196 VAKVFANDTDFIG------NGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEV 1249
N + + + + Y L R + G P+ SST+ L + V DV DE
Sbjct: 940 RMDFLINSSSGVVVTTTELDRERIAEYQL--RVVASDAGTPTKSSTSTLTIHVLDVNDET 997
Query: 1250 EMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYI 1294
P F Y + + E+V +V LN T++ N ++ Y+I
Sbjct: 998 -----PTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFI 1039
Score = 76.6 bits (180), Expect = 6e-13
Identities = 60/174 (34%), Positives = 88/174 (50%), Gaps = 14/174 (8%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSL-----FLEKELDLDAEHNLQANTFVL 274
A+D DLG TL Y + N K +SL+S G + L++E E L V
Sbjct: 807 AVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVS 864
Query: 275 QVQASQLNNPLK-TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
+ PLK T+ A V + LLDLNDN P F+ + ++E +P G S+ QV+A D
Sbjct: 865 VTDCGR--PPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDL 922
Query: 334 DQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D+G NG +Y++ P+ F I+ SG V T LDRE + +++V A +
Sbjct: 923 DEGLNGLVSYRMPVGMPRMDFLINSSSG--VVVTTTELDRERIAEYQLRVVASD 974
Score = 76.2 bits (179), Expect = 9e-13
Identities = 81/326 (24%), Positives = 133/326 (40%), Gaps = 21/326 (6%)
Query: 77 ISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIA------PIGPSLTI 130
+S ++ + I DV D PIF++ PY + E +P G I P G TI
Sbjct: 221 LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI 280
Query: 131 PLTVPRGLTIF-----KDIRAFDR--DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLL 183
+IF + + D+ N S V G + S
Sbjct: 281 VSVAGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTT 340
Query: 184 LR-KVLDYDAGDKEFQLVIMASGKRIHKEILFPEP--IHAIDQDLGVGATLRYELISGND 240
V+D + EF + ++ F P I +D+D G+ + L+ N
Sbjct: 341 FNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNS 400
Query: 241 RK-LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
+ S SV G + + + ++ + + + A++ + P A+V+I L++
Sbjct: 401 HHFIISPTSVQGKADIRIRVAIPLDYET-VDRYDFDLFANE-SVPDHVGYAKVKITLINE 458
Query: 300 NDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSG 359
NDN P F YNIS+ EN+ G SVL V+ATD D G GE +Y D FS+D +G
Sbjct: 459 NDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTG 518
Query: 360 WLTVRNQTVLDREAHSSLRMKVYAKE 385
+ + + LD E + + A++
Sbjct: 519 LIMLIAR--LDYELIQRFTLTIIARD 542
Score = 68.9 bits (161), Expect = 1e-10
Identities = 68/247 (27%), Positives = 102/247 (41%), Gaps = 24/247 (9%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
Q V +TLLD NDN+P + + Y ++ + + V AVDPDLG+NG ++Y
Sbjct: 762 QKTGIATVNITLLDINDNHPTWKDAPYY-INLVEMTPPDSDVTTVVAVDPDLGENGTLVY 820
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVA------ESP---ILEGRHALFVEASDQPANPSER 548
+Q + + +N TG + E+P E + V +D P +
Sbjct: 821 SIQPPNKF-----YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTD-CGRPPLK 874
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDV 606
S A V + + N D P F P+ V + G S+ Q+ D E V
Sbjct: 875 ATSSATVFVNL---LDLNDND-PTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLV 930
Query: 607 SYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVH 665
SY + G + F + SGV+ +L R Y VA S + T+H
Sbjct: 931 SYRMPVGMPR-MDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIH 989
Query: 666 VVDVNDE 672
V+DVNDE
Sbjct: 990 VLDVNDE 996
Score = 62.9 bits (146), Expect = 9e-09
Identities = 53/170 (31%), Positives = 77/170 (45%), Gaps = 8/170 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGND-RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D+D + Y ++S + F + G + LD E + L V
Sbjct: 588 LRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ-ISNGLIYLTV 646
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A NP + V IE+ D NDN P F Y +S+VEN+ G +VL + ATD D+
Sbjct: 647 MAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRS 706
Query: 337 -ENGE--FTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
E G+ Y L+ F I+ RSG +T ++LDRE S + V A
Sbjct: 707 REYGQESIIYSLEG-STQFRINARSGEIT--TTSLLDRETKSEYILIVRA 753
Score = 62.1 bits (144), Expect = 1e-08
Identities = 72/264 (27%), Positives = 121/264 (45%), Gaps = 38/264 (14%)
Query: 144 IRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKP--VLLLRKVLDYDA-GDKEFQLV 200
+RA D D P PN+ + YSIVS + G + S ++ V+ + + LDY+ + L
Sbjct: 588 LRATDEDSP--PNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLT 645
Query: 201 IMA---------SGKRIHKEIL--------FPEPIHAID--QDLGVGATLRYELISGNDR 241
+MA S + E+ F +P + + +++ GAT+ + + DR
Sbjct: 646 VMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDR 705
Query: 242 -KLFSLDSVNGSLFLEKELDLDAEHNLQANT----------FVLQVQASQ--LNNPLKTA 288
+ + +S+ SL + ++A T ++L V+A + + KT
Sbjct: 706 SREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTG 765
Query: 289 QARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDP 348
A V I LLD+NDN P ++ Y I++VE P V V+A D D GENG Y + P
Sbjct: 766 IATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP 825
Query: 349 KGAFSIDPRSGWLTVRNQTVLDRE 372
+S++ +G + +LDRE
Sbjct: 826 NKFYSLNSTTGKIRT-THAMLDRE 848
Score = 58.4 bits (135), Expect = 2e-07
Identities = 41/126 (32%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D G + Y DR FSLD G + L LD + F L + A
Sbjct: 489 ATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYEL-----IQRFTLTIIAR 541
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
T RV I +LD+NDN+P F+ D Y ++ EN P+ ++++ ATD+D N
Sbjct: 542 DGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNN 599
Query: 340 EFTYQL 345
+ TY +
Sbjct: 600 QITYSI 605
Score = 54.0 bits (124), Expect = 4e-06
Identities = 43/156 (27%), Positives = 72/156 (46%), Gaps = 16/156 (10%)
Query: 236 ISGNDR-KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
+SG + + F+++ G ++L + LD + + + F ++ S + +V I
Sbjct: 69 VSGEEASRFFAVEPDTGVVWLRQPLDRETK-----SEFTVEFSVSDHQGVITR---KVNI 120
Query: 295 ELLDLNDNLPEFEVDFYNISIVE-----NLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
++ D+NDN P F Y++ I E N P G + V ATD D G G Y P
Sbjct: 121 QVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS 180
Query: 350 GAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
F+ID G +TV + LD E + ++ V A +
Sbjct: 181 QFFAIDSARGIVTVIRE--LDYETTQAYQLTVNATD 214
Score = 52.8 bits (121), Expect = 9e-06
Identities = 99/413 (23%), Positives = 170/413 (41%), Gaps = 47/413 (11%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPD----LGQNGM 494
L S V V + + D NDN P F Y S+ N G + + A D D GQ
Sbjct: 656 LNSTVPVTIEVFDENDNPPTF-SKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQES- 713
Query: 495 VLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSL 552
++Y L+ ++ F+IN +G ++ E + + L V A D +++
Sbjct: 714 IIYSLEGSTQ------FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKT--- 764
Query: 553 AVVTIEVTR-GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQI-RVNDAFEQNDVSYDL 610
+ T+ +T N P D APY + + V + V+ +N L
Sbjct: 765 GIATVNITLLDINDNHPTWKD---APYYINLVEMTPPDSDVTTVVAVDPDLGENGT---L 818
Query: 611 LHGYEEGVPF-AVEERSGVI-TVVDDLSRYNRPMYDFE-----AVALQENAN--LSIVTN 661
++ + F ++ +G I T L R N ++ E V++ + L ++
Sbjct: 819 VYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSS 878
Query: 662 ATVHV--VDVNDERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRF 718
ATV V +D+ND + P + V E AG +I Q+ ++ NG + R
Sbjct: 879 ATVFVNLLDLNDNDPTF---QNLPFVAEVLEGIPAGVSIYQVVAIDLDEGL-NGLVSYRM 934
Query: 719 LIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIE 778
+ + D + + G + T LDRE+ Y++ V+A + G + + +TI++
Sbjct: 935 PVGMPR--MDFLINSSSGVVVTTTELDRERIAEYQLRVVAS-DAGTPTKSSTSTLTIHVL 991
Query: 779 DENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG 831
D ND P F A Y + E+ + E ++ + TD D G NA Y + G
Sbjct: 992 DVNDETPTFFPAVYNVSVSED--VPREFRV-VWLNCTDNDVGLNAELSYFITG 1041
Score = 44.0 bits (99), Expect = 0.004
Identities = 60/250 (24%), Positives = 103/250 (41%), Gaps = 36/250 (14%)
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTDFIGN-GNGLILYSLP-QRKNQQNLGLPSLSSTAI 1237
P Y ++ EN G TV + A D D G I+YSL + + N +++T++
Sbjct: 679 PAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSL 738
Query: 1238 LMVTVADVPDEVEMSDKPVFISRYYELEIEENVN---APVELVSLNLTEHYENFK-MRYY 1293
L + E + + I R + + N A V + L++ +++ +K YY
Sbjct: 739 L---------DRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYY 789
Query: 1294 I----LNENDTDIRRTFVIDP---RNGTL-YLVRSPDR---------EVKDTYEVIVRAE 1336
I + D+D+ +DP NGTL Y ++ P++ +++ T+ ++ R
Sbjct: 790 INLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDREN 849
Query: 1337 RQKYSRELPHMIYPVAEDVLEGMTKY--DVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTT 1394
+ EL I D K V V + D+NDN P F N P V +
Sbjct: 850 PDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ--NLPFVAEVLEG 907
Query: 1395 APFGYQVMQL 1404
P G + Q+
Sbjct: 908 IPAGVSIYQV 917
Score = 33.5 bits (73), Expect = 6.0
Identities = 16/45 (35%), Positives = 25/45 (55%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTP 111
+V AG S+ ++T+++ DVND P F Y+V+V E P
Sbjct: 970 VVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVP 1014
>AL359183-2|CAI13425.2| 1066|Homo sapiens cadherin-like 23 protein.
Length = 1066
Score = 135 bits (327), Expect = 1e-30
Identities = 215/803 (26%), Positives = 315/803 (39%), Gaps = 128/803 (15%)
Query: 403 WRRQPLETNAPLEKTT-YVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVF-- 459
W RQPL+ E T + D G T VN++V D NDN P F
Sbjct: 88 WLRQPLDRETKSEFTVEFSVSDHQGVITRK-----------VNIQVG--DVNDNAPTFHN 134
Query: 460 --VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNT 517
+ E N VGT I V A DPDLG G VLY Q S F I+
Sbjct: 135 QPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF-----FAIDSAR 189
Query: 518 GTVSVAESPILEGRHA--LFVEASDQP-ANPSERRYSLAVVTIEVTRGTKGNKPDIPDFM 574
G V+V E A L V A+DQ P +LA++ +V + P F+
Sbjct: 190 GIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV-------QDMDPIFI 242
Query: 575 GAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLH--GYEEGVPFAVEERSGVIT 630
PY + + GT+V I D + Y ++ G + FA++ SGV+T
Sbjct: 243 NLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNTNSI-FALDYISGVLT 301
Query: 631 VVDDLSRYNRPMYDFEAVALQENANLS---------IVTNATVHVVDVNDERGVLLKGAH 681
+ L R N P+Y + + L+ + T + V+D+ND +
Sbjct: 302 LNGLLDREN-PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEY 360
Query: 682 SPIIFHVKENSAGAAIG-QIFH-----TNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED 735
S I + + + Q+ +M +Y G + F+I+ + D
Sbjct: 361 SVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSHHFIIS-----PTSVQGKAD 415
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
I PLD E D Y + A N+ V G +V I + +ENDN P+F Y
Sbjct: 416 IRIRVAIPLDYETVDRYDFDLFA--NESVPDHVGYAKVKITLINENDNRPIFSQPLYNIS 473
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
+ EN +GT + + ATD D GT FGE V F D DR
Sbjct: 474 LYENVTVGTSVLT---VLATDNDAGT--------FGE------------VSYFFSDDPDR 510
Query: 856 EKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAG 915
+ L +DTG LI++I + ++ I+ + I R+ T G
Sbjct: 511 -----FSLD---KDTG-------LIMLIA-----RLDYELIQRFTLTIIARDGGGEETTG 550
Query: 916 FTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVY 975
I V N + + + EN P T +++L A D DS N QI Y
Sbjct: 551 RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITY------- 603
Query: 976 IPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE------FRLNISALDGGN--LND 1027
S +SA A YF I+ G+ +++ S P + E L + A+D GN LN
Sbjct: 604 ---SIVSASAFG--SYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNS 658
Query: 1028 NISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
+ V + V D ND+ P F K Y +V E + ++ATD D + I
Sbjct: 659 TVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL 718
Query: 1088 DTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG-XXXXXXXXXXXXXXXXDVND 1146
+ F I+ +G ++ LDRET+ +YIL V A D G D+ND
Sbjct: 719 EGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIND 778
Query: 1147 NSPKFY---AFDELLEWKHPEAD 1166
N P + + L+E P++D
Sbjct: 779 NHPTWKDAPYYINLVEMTPPDSD 801
Score = 101 bits (241), Expect = 3e-20
Identities = 175/724 (24%), Positives = 284/724 (39%), Gaps = 83/724 (11%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGK-VKAVDPDLGQNGMV-LYDLQRTSN 504
+ ++D NDN P F S Y ++ A+VG + ++ VD D G N M +Y + S+
Sbjct: 343 ILVIDINDNAPEFNSSE-YSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSH 401
Query: 505 LTITSPFKINPNTGT-VSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRGT 563
I SP + + VA E + + P Y+ +T+
Sbjct: 402 HFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDN 461
Query: 564 KGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVPFA 621
+ P F Y + NV +GTSV + NDA +VSY + F+
Sbjct: 462 R------PIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR---FS 512
Query: 622 VEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAH 681
+++ +G+I ++ L + +A ++ ++V+DVND K A+
Sbjct: 513 LDKDTGLIMLIARLDYELIQRFTLTIIA-RDGGGEETTGRVRINVLDVNDNVPTFQKDAY 571
Query: 682 SPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTD--DIAIAED-GTI 738
+ ++EN ++ Q+ + + + I + DI++ E G I
Sbjct: 572 ---VGALRENEP--SVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVI 626
Query: 739 FTQKPLDREK--RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFI 796
+PLD E+ + +TV+A + G VTI + DENDNPP F Y +
Sbjct: 627 SVSRPLDYEQISNGLIYLTVMA-MDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSV 685
Query: 797 MENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDRE 856
+EN G + N + E +Y+L EG F ++ +G + LDRE
Sbjct: 686 VENIMAGATVLFLNATDLDRSREYGQESIIYSL--EGSTQFRINARSGEITTTS-LLDRE 742
Query: 857 KKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGF 916
K SE LI+ D + N K I T
Sbjct: 743 TK----------------SEYILIVRAVDGG--------VGHNQKTGI-------ATVNI 771
Query: 917 TIIEVKPKNKFALDVDQLGPLFL-IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVY 975
T++++ + D P ++ + E P + + + A+D D G NG + Y
Sbjct: 772 TLLDINDNHPTWKDA----PYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ---- 823
Query: 976 IPPSKL-SADALEVKRYFVINERHGHVIVARSLPPESEF--RLNISALDGGN--LNDNIS 1030
PP+K S ++ K I H + P E+E ++ +S D G L S
Sbjct: 824 -PPNKFYSLNSTTGK----IRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSS 878
Query: 1031 VRVFVK--DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
VFV D+ND+ P F+ + V E + +V A D D G N ++Y +
Sbjct: 879 ATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGM 938
Query: 1089 TDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
+ F I+ +GV+ ELDRE +Y L VVA D G DVND +
Sbjct: 939 PRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAG-TPTKSSTSTLTIHVLDVNDET 997
Query: 1149 PKFY 1152
P F+
Sbjct: 998 PTFF 1001
Score = 99.1 bits (236), Expect = 1e-19
Identities = 183/777 (23%), Positives = 305/777 (39%), Gaps = 88/777 (11%)
Query: 582 VGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRP 641
+ + +G+SV Q+ D ND + G E FAVE +GV+ + L R +
Sbjct: 42 ISEDTPVGSSVTQLLAQDM--DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKS 99
Query: 642 MYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIF 701
+ E ++ ++ + I + V DVND +S I V IF
Sbjct: 100 EFTVE-FSVSDHQGV-ITRKVNIQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIF 157
Query: 702 HTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEF 760
N + G+V + Q + AI + G + + LD E Y++TV A
Sbjct: 158 IVNATDPDLGAGGSVLYSF---QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATD 214
Query: 761 NKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEG 820
+ + + I I D D P+F + Y I E+S GT ++ II A D D+G
Sbjct: 215 QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR---IITAIDQDKG 271
Query: 821 TNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELI 880
YT+ V NT + +LD ++ L+ R+ L S ++
Sbjct: 272 RPRGIGYTIVS-------VAGNTNSIF----ALDYISGVLTLNGLLDRENP-LYSHGFIL 319
Query: 881 IMIGDE-NDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFL 939
+ G E ND+ R + + T +I++ N A + +
Sbjct: 320 TVKGTELNDD-------------RTPSDATVTTTFNILVIDI---NDNAPEFNSSEYSVA 363
Query: 940 IPENIPIGTTI-IKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERH 998
I E +G + + + +D D GLN EVY+ + ++ + V +
Sbjct: 364 ITELAQVGFALPLFIQVVDKDEGLNSMF------EVYLVGN--NSHHFIISPTSVQGKAD 415
Query: 999 GHVIVARSLPPESEFRLNISALDGGNLNDNIS---VRVFVKDVNDHFPVFKKTWYNFNVE 1055
+ VA L E+ R + ++ D++ V++ + + ND+ P+F + YN ++
Sbjct: 416 IRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLY 475
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E + V ATD D G ++YF SD F + TG++ + LD E +
Sbjct: 476 ENVTVGTSVLTVLATDNDAGTFGEVSYFF--SDDPDRFSLDKDTGLIMLIARLDYELIQR 533
Query: 1116 YILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY--AFDELLEWKHPEADEL----- 1168
+ LT++ARD G DVNDN P F A+ L P +L
Sbjct: 534 FTLTIIARDGG---GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRA 590
Query: 1169 -------SNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQR 1221
+N S++ + + + + G V V + D+ NGLI ++
Sbjct: 591 TDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISV-SRPLDYEQISNGLIYLTV--- 646
Query: 1222 KNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL 1281
+ G P L+ST + + V D E + P F Y + + EN+ A ++ LN
Sbjct: 647 -MAMDAGNPPLNSTVPVTIEVFD-----ENDNPPTFSKPAYFVSVVENIMAGATVLFLNA 700
Query: 1282 T--EHYENFKMRYYILN-ENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
T + + I + E T R I+ R+G + DRE K Y +IVRA
Sbjct: 701 TDLDRSREYGQESIIYSLEGSTQFR----INARSGEITTTSLLDRETKSEYILIVRA 753
Score = 96.7 bits (230), Expect = 6e-19
Identities = 79/287 (27%), Positives = 135/287 (47%), Gaps = 20/287 (6%)
Query: 71 GAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSL 128
G G NQ + +V + + D+NDN P + D PY++ + E+TP + + + P +G +
Sbjct: 757 GVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENG 816
Query: 129 TIPLTVPRGLTIFK------DIRA----FDRDKPNTPNSDVHYSIV-SGNDDGHFALESS 177
T+ ++ + IR DR+ P+ +++ IV S D G L+++
Sbjct: 817 TLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKAT 876
Query: 178 HKPVLLLRKVLDYDAGDKEFQ-LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELI 236
+ + +LD + D FQ L +A + + AID D G+ + Y +
Sbjct: 877 SSATVFVN-LLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP 935
Query: 237 SGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
G R F ++S +G + ELD + Q L+V AS P K++ + + I +
Sbjct: 936 VGMPRMDFLINSSSGVVVTTTELDRERIAEYQ-----LRVVASDAGTPTKSSTSTLTIHV 990
Query: 297 LDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTY 343
LD+ND P F YN+S+ E++P F V+ + TD D G N E +Y
Sbjct: 991 LDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSY 1037
Score = 95.5 bits (227), Expect = 1e-18
Identities = 131/529 (24%), Positives = 221/529 (41%), Gaps = 58/529 (10%)
Query: 440 MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
+ + V++TL++ NDN P+F LY S+ N VGT + V A D D G G V Y
Sbjct: 446 VGYAKVKITLINENDNRPIF-SQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF 504
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTI 557
+ F ++ +TG + + E R L + A D + R + V+ +
Sbjct: 505 SDDPDR-----FSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDV 559
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGYE 615
++P F Y + N T + ++R D N ++Y ++
Sbjct: 560 N---------DNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASA 610
Query: 616 EGVPFAVE--ERSGVITVVD--DLSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVDVN 670
G F + E GVI+V D + + + +A+ N L+ T+ V D N
Sbjct: 611 FGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDEN 670
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
D K A+ + V+ AGA + + T++ G ++ I + + T
Sbjct: 671 DNPPTFSKPAY--FVSVVENIMAGATVLFLNATDLDRSREYGQESI---IYSLEGSTQFR 725
Query: 731 AIAEDGTIFTQKPLDREKRDVYRMTVIA-EFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
A G I T LDRE + Y + V A + G GI V I + D NDN P ++
Sbjct: 726 INARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKD 785
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFI 849
A Y ++E + +++ + A D D G N +Y++ K + ++ TG ++
Sbjct: 786 APYYINLVEMTPPDSDV---TTVVAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTT 841
Query: 850 GDSLDREK------KIMYKLSLVARDTG----GLSSEAELIIMIGDENDNKPEFNQIEEN 899
LDRE ++M K+ + D G +S A + + + D NDN P F +
Sbjct: 842 HAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFV 901
Query: 900 SKVRIHRETKLNG-TAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIG 947
++V L G AG +I +V A+D+D+ G L+ +P+G
Sbjct: 902 AEV-------LEGIPAGVSIYQV-----VAIDLDE-GLNGLVSYRMPVG 937
Score = 89.8 bits (213), Expect = 6e-17
Identities = 91/332 (27%), Positives = 145/332 (43%), Gaps = 24/332 (7%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF---IFLIAPIGPSLTIPLTVPRGLT 139
V + + DVNDN P F + PY V + E+ TG IF++ P L +V
Sbjct: 118 VNIQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQ 177
Query: 140 IFKDIRAFDRDKPN-TPNSDVHYSIVSGNDDGHFALESSH-KPVLLLRK--VLDYDAGDK 195
A D + T ++ Y A + +P+ L ++ D D
Sbjct: 178 PPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDM 237
Query: 196 EFQLVIMASGKRIHKEI---LFPEPIHAIDQDLGVGATLRYELIS--GNDRKLFSLDSVN 250
+ + + I++ I AIDQD G + Y ++S GN +F+LD ++
Sbjct: 238 DPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSVAGNTNSIFALDYIS 297
Query: 251 GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV----EIELLDLNDNLPEF 306
G L L LD E+ L ++ F+L V+ ++LN+ + A V I ++D+NDN PEF
Sbjct: 298 GVLTLNGLLD--RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEF 355
Query: 307 EVDFYNISIVENLPNGFSV-LQVMATDKDQGENGEF-TYQLDDPKGAFSIDPRS----GW 360
Y+++I E GF++ L + DKD+G N F Y + + F I P S
Sbjct: 356 NSSEYSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNSHHFIISPTSVQGKAD 415
Query: 361 LTVRNQTVLDREAHSSLRMKVYAKETNPSVVG 392
+ +R LD E ++A E+ P VG
Sbjct: 416 IRIRVAIPLDYETVDRYDFDLFANESVPDHVG 447
Score = 86.6 bits (205), Expect = 6e-16
Identities = 107/407 (26%), Positives = 162/407 (39%), Gaps = 45/407 (11%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN T TI EV +N + + ENI G T++ LNA DLD Y
Sbjct: 656 LNSTVPVTI-EVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSR----EYG 710
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG---N 1024
S +Y +LE F IN R G + L E SE+ L + A+DGG N
Sbjct: 711 QESIIY---------SLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHN 761
Query: 1025 LNDNI-SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYF 1083
I +V + + D+ND+ P +K Y N+ E + V A D D G+N L Y
Sbjct: 762 QKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS 821
Query: 1084 IQPSDTDLPFEISPLTG-VLSVNGELDRETEDKY------ILTVVARDNGX-XXXXXXXX 1135
IQP + + ++ TG + + + LDRE D + + V D G
Sbjct: 822 IQPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 879
Query: 1136 XXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTT 1195
D+NDN P F + E +S + ++ + + P+G
Sbjct: 880 TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMP 939
Query: 1196 VAKVFANDTDFIG------NGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEV 1249
N + + + + Y L R + G P+ SST+ L + V DV DE
Sbjct: 940 RMDFLINSSSGVVVTTTELDRERIAEYQL--RVVASDAGTPTKSSTSTLTIHVLDVNDET 997
Query: 1250 EMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYI 1294
P F Y + + E+V +V LN T++ N ++ Y+I
Sbjct: 998 -----PTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFI 1039
Score = 76.6 bits (180), Expect = 6e-13
Identities = 60/174 (34%), Positives = 88/174 (50%), Gaps = 14/174 (8%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSL-----FLEKELDLDAEHNLQANTFVL 274
A+D DLG TL Y + N K +SL+S G + L++E E L V
Sbjct: 807 AVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVS 864
Query: 275 QVQASQLNNPLK-TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
+ PLK T+ A V + LLDLNDN P F+ + ++E +P G S+ QV+A D
Sbjct: 865 VTDCGR--PPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDL 922
Query: 334 DQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D+G NG +Y++ P+ F I+ SG V T LDRE + +++V A +
Sbjct: 923 DEGLNGLVSYRMPVGMPRMDFLINSSSG--VVVTTTELDRERIAEYQLRVVASD 974
Score = 76.2 bits (179), Expect = 9e-13
Identities = 81/326 (24%), Positives = 133/326 (40%), Gaps = 21/326 (6%)
Query: 77 ISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIA------PIGPSLTI 130
+S ++ + I DV D PIF++ PY + E +P G I P G TI
Sbjct: 221 LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI 280
Query: 131 PLTVPRGLTIF-----KDIRAFDR--DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLL 183
+IF + + D+ N S V G + S
Sbjct: 281 VSVAGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTT 340
Query: 184 LR-KVLDYDAGDKEFQLVIMASGKRIHKEILFPEP--IHAIDQDLGVGATLRYELISGND 240
V+D + EF + ++ F P I +D+D G+ + L+ N
Sbjct: 341 FNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNNS 400
Query: 241 RK-LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
+ S SV G + + + ++ + + + A++ + P A+V+I L++
Sbjct: 401 HHFIISPTSVQGKADIRIRVAIPLDYET-VDRYDFDLFANE-SVPDHVGYAKVKITLINE 458
Query: 300 NDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSG 359
NDN P F YNIS+ EN+ G SVL V+ATD D G GE +Y D FS+D +G
Sbjct: 459 NDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTG 518
Query: 360 WLTVRNQTVLDREAHSSLRMKVYAKE 385
+ + + LD E + + A++
Sbjct: 519 LIMLIAR--LDYELIQRFTLTIIARD 542
Score = 68.9 bits (161), Expect = 1e-10
Identities = 68/247 (27%), Positives = 102/247 (41%), Gaps = 24/247 (9%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
Q V +TLLD NDN+P + + Y ++ + + V AVDPDLG+NG ++Y
Sbjct: 762 QKTGIATVNITLLDINDNHPTWKDAPYY-INLVEMTPPDSDVTTVVAVDPDLGENGTLVY 820
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVA------ESP---ILEGRHALFVEASDQPANPSER 548
+Q + + +N TG + E+P E + V +D P +
Sbjct: 821 SIQPPNKF-----YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTD-CGRPPLK 874
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDV 606
S A V + + N D P F P+ V + G S+ Q+ D E V
Sbjct: 875 ATSSATVFVNL---LDLNDND-PTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLV 930
Query: 607 SYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVH 665
SY + G + F + SGV+ +L R Y VA S + T+H
Sbjct: 931 SYRMPVGMPR-MDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIH 989
Query: 666 VVDVNDE 672
V+DVNDE
Sbjct: 990 VLDVNDE 996
Score = 62.9 bits (146), Expect = 9e-09
Identities = 53/170 (31%), Positives = 77/170 (45%), Gaps = 8/170 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGND-RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D+D + Y ++S + F + G + LD E + L V
Sbjct: 588 LRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ-ISNGLIYLTV 646
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A NP + V IE+ D NDN P F Y +S+VEN+ G +VL + ATD D+
Sbjct: 647 MAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRS 706
Query: 337 -ENGE--FTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
E G+ Y L+ F I+ RSG +T ++LDRE S + V A
Sbjct: 707 REYGQESIIYSLEG-STQFRINARSGEIT--TTSLLDRETKSEYILIVRA 753
Score = 62.1 bits (144), Expect = 1e-08
Identities = 72/264 (27%), Positives = 121/264 (45%), Gaps = 38/264 (14%)
Query: 144 IRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKP--VLLLRKVLDYDA-GDKEFQLV 200
+RA D D P PN+ + YSIVS + G + S ++ V+ + + LDY+ + L
Sbjct: 588 LRATDEDSP--PNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLT 645
Query: 201 IMA---------SGKRIHKEIL--------FPEPIHAID--QDLGVGATLRYELISGNDR 241
+MA S + E+ F +P + + +++ GAT+ + + DR
Sbjct: 646 VMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDR 705
Query: 242 -KLFSLDSVNGSLFLEKELDLDAEHNLQANT----------FVLQVQASQ--LNNPLKTA 288
+ + +S+ SL + ++A T ++L V+A + + KT
Sbjct: 706 SREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTG 765
Query: 289 QARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDP 348
A V I LLD+NDN P ++ Y I++VE P V V+A D D GENG Y + P
Sbjct: 766 IATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP 825
Query: 349 KGAFSIDPRSGWLTVRNQTVLDRE 372
+S++ +G + +LDRE
Sbjct: 826 NKFYSLNSTTGKIRT-THAMLDRE 848
Score = 58.4 bits (135), Expect = 2e-07
Identities = 41/126 (32%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D G + Y DR FSLD G + L LD + F L + A
Sbjct: 489 ATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYEL-----IQRFTLTIIAR 541
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
T RV I +LD+NDN+P F+ D Y ++ EN P+ ++++ ATD+D N
Sbjct: 542 DGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNN 599
Query: 340 EFTYQL 345
+ TY +
Sbjct: 600 QITYSI 605
Score = 54.0 bits (124), Expect = 4e-06
Identities = 43/156 (27%), Positives = 72/156 (46%), Gaps = 16/156 (10%)
Query: 236 ISGNDR-KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
+SG + + F+++ G ++L + LD + + + F ++ S + +V I
Sbjct: 69 VSGEEASRFFAVEPDTGVVWLRQPLDRETK-----SEFTVEFSVSDHQGVITR---KVNI 120
Query: 295 ELLDLNDNLPEFEVDFYNISIVE-----NLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
++ D+NDN P F Y++ I E N P G + V ATD D G G Y P
Sbjct: 121 QVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS 180
Query: 350 GAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
F+ID G +TV + LD E + ++ V A +
Sbjct: 181 QFFAIDSARGIVTVIRE--LDYETTQAYQLTVNATD 214
Score = 52.8 bits (121), Expect = 9e-06
Identities = 99/413 (23%), Positives = 170/413 (41%), Gaps = 47/413 (11%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPD----LGQNGM 494
L S V V + + D NDN P F Y S+ N G + + A D D GQ
Sbjct: 656 LNSTVPVTIEVFDENDNPPTF-SKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQES- 713
Query: 495 VLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSL 552
++Y L+ ++ F+IN +G ++ E + + L V A D +++
Sbjct: 714 IIYSLEGSTQ------FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKT--- 764
Query: 553 AVVTIEVTR-GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQI-RVNDAFEQNDVSYDL 610
+ T+ +T N P D APY + + V + V+ +N L
Sbjct: 765 GIATVNITLLDINDNHPTWKD---APYYINLVEMTPPDSDVTTVVAVDPDLGENGT---L 818
Query: 611 LHGYEEGVPF-AVEERSGVI-TVVDDLSRYNRPMYDFE-----AVALQENAN--LSIVTN 661
++ + F ++ +G I T L R N ++ E V++ + L ++
Sbjct: 819 VYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSS 878
Query: 662 ATVHV--VDVNDERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRF 718
ATV V +D+ND + P + V E AG +I Q+ ++ NG + R
Sbjct: 879 ATVFVNLLDLNDNDPTF---QNLPFVAEVLEGIPAGVSIYQVVAIDLDEGL-NGLVSYRM 934
Query: 719 LIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIE 778
+ + D + + G + T LDRE+ Y++ V+A + G + + +TI++
Sbjct: 935 PVGMPR--MDFLINSSSGVVVTTTELDRERIAEYQLRVVAS-DAGTPTKSSTSTLTIHVL 991
Query: 779 DENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG 831
D ND P F A Y + E+ + E ++ + TD D G NA Y + G
Sbjct: 992 DVNDETPTFFPAVYNVSVSED--VPREFRV-VWLNCTDNDVGLNAELSYFITG 1041
Score = 44.0 bits (99), Expect = 0.004
Identities = 60/250 (24%), Positives = 103/250 (41%), Gaps = 36/250 (14%)
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTDFIGN-GNGLILYSLP-QRKNQQNLGLPSLSSTAI 1237
P Y ++ EN G TV + A D D G I+YSL + + N +++T++
Sbjct: 679 PAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSL 738
Query: 1238 LMVTVADVPDEVEMSDKPVFISRYYELEIEENVN---APVELVSLNLTEHYENFK-MRYY 1293
L + E + + I R + + N A V + L++ +++ +K YY
Sbjct: 739 L---------DRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYY 789
Query: 1294 I----LNENDTDIRRTFVIDP---RNGTL-YLVRSPDR---------EVKDTYEVIVRAE 1336
I + D+D+ +DP NGTL Y ++ P++ +++ T+ ++ R
Sbjct: 790 INLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDREN 849
Query: 1337 RQKYSRELPHMIYPVAEDVLEGMTKY--DVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTT 1394
+ EL I D K V V + D+NDN P F N P V +
Sbjct: 850 PDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ--NLPFVAEVLEG 907
Query: 1395 APFGYQVMQL 1404
P G + Q+
Sbjct: 908 IPAGVSIYQV 917
Score = 33.5 bits (73), Expect = 6.0
Identities = 16/45 (35%), Positives = 25/45 (55%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTP 111
+V AG S+ ++T+++ DVND P F Y+V+V E P
Sbjct: 970 VVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVP 1014
>D87469-1|BAA13407.2| 2854|Homo sapiens KIAA0279 protein protein.
Length = 2854
Score = 134 bits (324), Expect = 2e-30
Identities = 137/469 (29%), Positives = 213/469 (45%), Gaps = 41/469 (8%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L + +V VT+LD NDNNP F Y + +A VGT + V AVD D + ++ Y
Sbjct: 521 LTASASVSVTVLDVNDNNPTFTQPE-YTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQ 577
Query: 499 LQRTSNLTITSPFKINPNTG--TVSVAESPI---LEGRHALFVEASDQPANPSERRYSLA 553
+ TS T + F I +G VS+A P+ LE ++ L V ASD R A
Sbjct: 578 I--TSGNT-RNRFSITSQSGGGLVSLA-LPLDYKLERQYVLAVTASDGT------RQDTA 627
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHG 613
+ + VT P F + Y V + GT+V I D E + + +
Sbjct: 628 QIVVNVTDANTHR----PVFQSSHYTVNVNEDRPAGTTVVLISATD--EDTGENARITYF 681
Query: 614 YEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA--NLSIVTNATVHVVDVN 670
E+ +P F ++ +G +T +L ++ Y A+ ++N S T + V DVN
Sbjct: 682 MEDSIPQFRIDADTGAVTTQAELDYEDQVSYTL-AITARDNGIPQKSDTTYLEILVNDVN 740
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
D L+ ++ ++ ++ ++ QI T+ S G V + D D
Sbjct: 741 DNAPQFLRDSYQGSVY--EDVPPFTSVLQISATDRDS---GLNGRVFYTFQGGDDGDGDF 795
Query: 731 AI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
+ + G + T + LDRE Y + A +KG+ +VT+ + D NDNPPVFE
Sbjct: 796 IVESTSGIVRTLRRLDRENVAQYVLRAYA-VDKGMPPARTPMEVTVTVLDVNDNPPVFEQ 854
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTGVVKF 848
++ F+ ENS IG + + ATD DEGTNA MY + G E+F +D +G +
Sbjct: 855 DEFDVFVEENSPIGLAVAR---VTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTA 911
Query: 849 IGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIE 897
+ D LD E + Y L ++ + L S A + + + D NDN P E
Sbjct: 912 LVD-LDYEDRPEYVL-VIQATSAPLVSRATVHVRLLDRNDNPPVLGNFE 958
Score = 128 bits (310), Expect = 1e-28
Identities = 128/477 (26%), Positives = 208/477 (43%), Gaps = 32/477 (6%)
Query: 457 PVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPN 516
P F P + Y+ ++ N GT + ++A+DPD G+ G + Y + + F ++P
Sbjct: 110 PQFQPPS-YQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPV 168
Query: 517 TGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIPDFM 574
TG V+ AE E + H V A D + RR +LA +TI V T N D P F
Sbjct: 169 TGAVTTAEELDRETKSTHVFRVTAQD---HGMPRRSALATLTILV---TDTNDHD-PVFE 221
Query: 575 GAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVP---FAVEERSGVI 629
Y+ + N+ +G V +R DA ++ Y LL G G P F ++ RSGVI
Sbjct: 222 QQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEG-SGGSPSEVFEIDPRSGVI 280
Query: 630 TVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVK 689
+ R Y A + + + + V D+ + + + V+
Sbjct: 281 RTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVR 340
Query: 690 ENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKR 749
E+ A + S V + I + A+ G + PLD E
Sbjct: 341 EDVTPGA--PVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETT 398
Query: 750 DVYRMTVIA-EFNKGVISG-AGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIK 807
Y + V A + + +S +G+ VT+ + D NDN P+F ++ ++E+ +G +
Sbjct: 399 KEYTLRVRAQDGGRPPLSNVSGL--VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVL 456
Query: 808 MDNIIKATDADEGTNALFMYTLFGEGKEM-FDVDENTGVVKFIGDSLDREKKIMYKLSLV 866
++A DAD G NA Y L G G + F ++ TG + + LDRE+ Y +
Sbjct: 457 H---VQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWIS-VAAELDREEVDFYSFGVE 512
Query: 867 ARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
ARD G L++ A + + + D NDN P F Q E VR++ + + GT+ T+ V
Sbjct: 513 ARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYT--VRLNEDAAV-GTSVVTVSAV 566
Score = 124 bits (299), Expect = 2e-27
Identities = 125/471 (26%), Positives = 198/471 (42%), Gaps = 38/471 (8%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V +LD NDN P+FV S ++ ++ + +G ++ V+A+D D G N + Y R +
Sbjct: 422 VTVQVLDINDNAPIFV-STPFQATVLESVPLGYLVLHVQAIDADAGDNARLEY---RLAG 477
Query: 505 LTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
+ PF IN TG +SVA E ++ VEA D S++V ++V
Sbjct: 478 VGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDN 537
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAV 622
P F Y + + +GTSV + D + ++Y + G F++
Sbjct: 538 N-------PTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRN-RFSI 589
Query: 623 EERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHS 682
+SG V L + + + V+V D N R V + +H
Sbjct: 590 TSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPV-FQSSHY 648
Query: 683 PIIFHVKENSAGAAIGQIFHTNMSSIYGNGTG-NVRFLIANQQDVTDDIAIAEDGTIFTQ 741
+ + ++ AG + I T+ TG N R + + A+ G + TQ
Sbjct: 649 TVNVN-EDRPAGTTVVLISATD------EDTGENARITYFMEDSIPQFRIDADTGAVTTQ 701
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
LD E + Y + + A N G+ + + I + D NDN P F +Y+G + E+
Sbjct: 702 AELDYEDQVSYTLAITARDN-GIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVP 760
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFG--EGKEMFDVDENTGVVKFIGDSLDREKKI 859
T + I ATD D G N YT G +G F V+ +G+V+ + LDRE
Sbjct: 761 PFTSVLQ---ISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTL-RRLDRENVA 816
Query: 860 MYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ------IEENSKV 902
Y L A D G + E+ + + D NDN P F Q +EENS +
Sbjct: 817 QYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPI 867
Score = 117 bits (282), Expect = 3e-25
Identities = 178/731 (24%), Positives = 298/731 (40%), Gaps = 104/731 (14%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V +++ D NDN P F Y ++ + G + +V A D D G N +V Y + +
Sbjct: 316 VFLSVEDDNDNAPQFSEKR-YVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGN- 373
Query: 505 LTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLAVVTIEVTR 561
F ++ TG + V SP+ + L V A D P L VT++V
Sbjct: 374 --ARGQFYLDAQTGALDVV-SPLDYETTKEYTLRVRAQDGGRPPLSNVSGL--VTVQVL- 427
Query: 562 GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDL-LHGYEEGVPF 620
+ P F+ P++ V +V +G V ++ DA ++ + L G PF
Sbjct: 428 ---DINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPF 484
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDERGVLLKG 679
+ +G I+V +L R Y F A L+ + +V V+DVND +
Sbjct: 485 TINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQP 544
Query: 680 AHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIA--NQQDVTDDIAIAEDGT 737
++ V+ N AA+G T +S++ + + + I N ++ + + G
Sbjct: 545 EYT-----VRLNE-DAAVGTSVVT-VSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGL 597
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
+ PLD + Y + V A + G Q+ + + D N + PVF+ + Y +
Sbjct: 598 VSLALPLDYKLERQYVLAVTA--SDGTRQDTA--QIVVNVTDANTHRPVFQSSHYTVNVN 653
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREK 857
E+ GT + + I ATD D G EN + F+ DS+ + +
Sbjct: 654 EDRPAGTTVVL---ISATDEDTG--------------------ENARITYFMEDSIPQFR 690
Query: 858 KIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFT 917
+ DTG ++++AEL D D Q+ + R+ + + T
Sbjct: 691 --------IDADTGAVTTQAEL-----DYED------QVSYTLAITA-RDNGIPQKSDTT 730
Query: 918 IIEVKPKNKFALDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEF 970
+E+ DV+ P FL + E++P T++++++A D DSGLNG++ Y F
Sbjct: 731 YLEI-----LVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTF 785
Query: 971 NSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LN 1026
D F++ G V R L E+ ++ L A+D G
Sbjct: 786 QGG-----DDGDGD-------FIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPAR 833
Query: 1027 DNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQP 1086
+ V V V DVND+ PVF++ ++ VEE + +V ATD D G NA + Y I
Sbjct: 834 TPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVE 893
Query: 1087 SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+ F++ +G L+ +LD E +Y+L + A D ND
Sbjct: 894 GNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQA----TSAPLVSRATVHVRLLDRND 949
Query: 1147 NSPKFYAFDEL 1157
N P F+ L
Sbjct: 950 NPPVLGNFEIL 960
Score = 106 bits (254), Expect = 7e-22
Identities = 116/432 (26%), Positives = 188/432 (43%), Gaps = 59/432 (13%)
Query: 929 LDVDQLGPLFLIPE-------NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LDV+ P F PE + +GT+++ ++A+D D+ + I Y+ S
Sbjct: 532 LDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSG-------- 581
Query: 982 SADALEVKRYFVINERHGHVIVARSLPP----ESEFRLNISALDGGNLNDNISVRVFVKD 1037
+ F I + G +V+ +LP E ++ L ++A DG D + V V D
Sbjct: 582 -----NTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTR-QDTAQIVVNVTD 635
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISP 1097
N H PVF+ + Y NV E + + + ATD D G+NA +TYF++ D+ F I
Sbjct: 636 ANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFME--DSIPQFRIDA 693
Query: 1098 LTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDEL 1157
TG ++ ELD E + Y L + ARDNG DVNDN+P+F D
Sbjct: 694 DTGAVTTQAELDYEDQVSYTLAITARDNG-IPQKSDTTYLEILVNDVNDNAPQFLR-DSY 751
Query: 1158 LEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYS 1217
+ + F SV+ I N + T D DFI I+ +
Sbjct: 752 QGSVYEDVPP-----FTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRT 806
Query: 1218 LPQRKNQQNL------------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELE 1265
L +R +++N+ G+P + + VTV DV D + PVF +++
Sbjct: 807 L-RRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVND-----NPPVFEQDEFDVF 860
Query: 1266 IEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDR 1323
+EEN + + + T+ E N ++ Y I+ N I F +D +G L + D
Sbjct: 861 VEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGN---IPEVFQLDIFSGELTALVDLDY 917
Query: 1324 EVKDTYEVIVRA 1335
E + Y ++++A
Sbjct: 918 EDRPEYVLVIQA 929
Score = 99.5 bits (237), Expect = 8e-20
Identities = 126/488 (25%), Positives = 203/488 (41%), Gaps = 59/488 (12%)
Query: 906 RETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQ 965
R+ T + V+ N A + + + E++ G ++++ A D D G N
Sbjct: 305 RDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAV 364
Query: 966 IRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGG 1023
+ Y S +S +A + F ++ + G + V L E+ E+ L + A DGG
Sbjct: 365 VHY----------SIMSGNA---RGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGG 411
Query: 1024 NLN-DNIS--VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANL 1080
N+S V V V D+ND+ P+F T + V E+ ++ V A DAD G NA L
Sbjct: 412 RPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARL 471
Query: 1081 TYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXX 1140
Y + D PF I+ TG +SV ELDRE D Y V ARD+G
Sbjct: 472 EYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHG-TPALTASASVSVT 530
Query: 1141 XXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVF 1200
DVNDN+P F PE N + +V V + ++ +A T
Sbjct: 531 VLDVNDNNPTF---------TQPEYTVRLNED-AAVGTSVVTVSAVDRDAHSVITYQITS 580
Query: 1201 ANDTDFIG----NGNGLILYSLP-QRKNQQNLGLPSLSSTAILMVTVADVPDEVEM-SDK 1254
N + +G GL+ +LP K ++ L +S T V + + + +
Sbjct: 581 GNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHR 640
Query: 1255 PVFISRYYELEIEENVNAPVELVSLNLTEH--YENFKMRYYILNENDTDIRRTFVIDPRN 1312
PVF S +Y + + E+ A +V ++ T+ EN ++ Y++ D F ID
Sbjct: 641 PVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFM-----EDSIPQFRIDADT 695
Query: 1313 GTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKD 1372
G + D E + +Y + + A +P + T Y + + + D
Sbjct: 696 GAVTTQAELDYEDQVSYTLAITAR----DNGIPQ----------KSDTTY---LEILVND 738
Query: 1373 VNDNSPKF 1380
VNDN+P+F
Sbjct: 739 VNDNAPQF 746
Score = 95.5 bits (227), Expect = 1e-18
Identities = 86/319 (26%), Positives = 145/319 (45%), Gaps = 36/319 (11%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTP--------------TGEKAFI-FLIAPIGPS 127
VTV + D+NDN PIF+ TP+ TV E P G+ A + + +A +G
Sbjct: 422 VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHD 481
Query: 128 LTIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKV 187
P T+ G DR++ D + V D G AL +S + + V
Sbjct: 482 F--PFTINNGTGWISVAAELDREEV-----DFYSFGVEARDHGTPALTASASVSVTVLDV 534
Query: 188 LDYDAGDKEFQLVI-MASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSL 246
D + + + + + + ++ + A+D+D + + Y++ SGN R FS+
Sbjct: 535 NDNNPTFTQPEYTVRLNEDAAVGTSVV---TVSAVDRD--AHSVITYQITSGNTRNRFSI 589
Query: 247 DSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF 306
S +G + L LD + Q +VL V AS + + A++ + + D N + P F
Sbjct: 590 TSQSGGGLVSLALPLDYKLERQ---YVLAVTAS---DGTRQDTAQIVVNVTDANTHRPVF 643
Query: 307 EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQ 366
+ Y +++ E+ P G +V+ + ATD+D GEN TY ++D F ID +G V Q
Sbjct: 644 QSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTG--AVTTQ 701
Query: 367 TVLDREAHSSLRMKVYAKE 385
LD E S + + A++
Sbjct: 702 AELDYEDQVSYTLAITARD 720
Score = 87.4 bits (207), Expect = 3e-16
Identities = 62/176 (35%), Positives = 85/176 (48%), Gaps = 15/176 (8%)
Query: 218 IHAIDQDLGVGATLRYE---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
+ AID D G L Y L + FSLD V G++ +ELD + + +T V
Sbjct: 134 LRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDRETK-----STHVF 188
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+V A P ++A A + I + D ND+ P FE Y S+ ENL G+ VL V ATD D
Sbjct: 189 RVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGD 248
Query: 335 QGENGEFTYQL-----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N Y+L P F IDPRSG +R + +DRE S ++ V A +
Sbjct: 249 APPNANILYRLLEGSGGSPSEVFEIDPRSG--VIRTRGPVDREEVESYQLTVEASD 302
Score = 86.2 bits (204), Expect = 8e-16
Identities = 115/460 (25%), Positives = 191/460 (41%), Gaps = 56/460 (12%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN P GT + L A+D D G G++ Y ++ + S+ + ++F ++ G
Sbjct: 121 VPENQPAGTPVASLRAIDPDEGEAGRLEYTMDA---LFDSRSN-------QFFSLDPVTG 170
Query: 1000 HVIVARSLPPESEFR--LNISALDGGNLNDNI--SVRVFVKDVNDHFPVFKKTWYNFNVE 1055
V A L E++ ++A D G + ++ + V D NDH PVF++ Y ++
Sbjct: 171 AVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLR 230
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP---FEISPLTGVLSVNGELDRET 1112
E + V ATD D NAN+ Y + P FEI P +GV+ G +DRE
Sbjct: 231 ENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREE 290
Query: 1113 EDKYILTVVARDNGXX-XXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKH---PEADEL 1168
+ Y LTV A D G D NDN+P+F +++ + P A L
Sbjct: 291 VESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVL 350
Query: 1169 --SNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQN 1226
+ + + V+ + + NA G D + + R Q+
Sbjct: 351 RVTASDRDKGSNAVVHYSIMSGNAR-GQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQD 409
Query: 1227 LGLPSLSS-TAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL---- 1281
G P LS+ + ++ V V D+ D + P+F+S ++ + E+V P+ + L++
Sbjct: 410 GGRPPLSNVSGLVTVQVLDIND-----NAPIFVSTPFQATVLESV--PLGYLVLHVQAID 462
Query: 1282 TEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYS 1341
+ +N ++ Y + D F I+ G + + DRE D Y V A
Sbjct: 463 ADAGDNARLEYRLAGVGH-DF--PFTINNGTGWISVAAELDREEVDFYSFGVEAR----- 514
Query: 1342 RELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
+ +T V V + DVNDN+P FT
Sbjct: 515 -----------DHGTPALTA-SASVSVTVLDVNDNNPTFT 542
Score = 86.2 bits (204), Expect = 8e-16
Identities = 66/236 (27%), Positives = 109/236 (46%), Gaps = 13/236 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D+D G A + Y ++SGN R F LD+ G+L + LD + + L+V+
Sbjct: 352 VTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYET-----TKEYTLRVR 406
Query: 278 ASQLNNP-LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A P L V +++LD+NDN P F + +++E++P G+ VL V A D D G
Sbjct: 407 AQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAG 466
Query: 337 ENGEFTYQLD--DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
+N Y+L F+I+ +GW++V + LDRE V A++ P++ +
Sbjct: 467 DNARLEYRLAGVGHDFPFTINNGTGWISVAAE--LDREEVDFYSFGVEARDHGTPALTAS 524
Query: 394 FADSQRIAKWRRQPLETNAPLEKTTYVFPD-KVGTKTENIEYYDEQLMSFVNVEVT 448
+ S + P E T + D VGT + D S + ++T
Sbjct: 525 ASVSVTVLDVNDNNPTFTQP-EYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQIT 579
Score = 79.0 bits (186), Expect = 1e-13
Identities = 57/169 (33%), Positives = 88/169 (52%), Gaps = 12/169 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I A D+D G A + Y + + F +D+ G++ + ELD + + + + L +
Sbjct: 665 ISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQVS-----YTLAIT 717
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P K+ +EI + D+NDN P+F D Y S+ E++P SVLQ+ ATD+D G
Sbjct: 718 ARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGL 777
Query: 338 NGE--FTYQ-LDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
NG +T+Q DD G F ++ SG VR LDRE + ++ YA
Sbjct: 778 NGRVFYTFQGGDDGDGDFIVESTSG--IVRTLRRLDRENVAQYVLRAYA 824
Score = 74.5 bits (175), Expect = 3e-12
Identities = 80/332 (24%), Positives = 137/332 (41%), Gaps = 23/332 (6%)
Query: 44 VDSDSPQNVVKFRLGCDFD-EGDDLVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPY 102
+ S S +V L D+ E ++ + A + V + D N + P+F + Y
Sbjct: 589 ITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHY 648
Query: 103 HVTVDELTPTGEKAFIFLIAP--IGPSLTIPLTVPRGLTIFK---DIRAFDRDKPNTPNS 157
V V+E P G + G + I + + F+ D A
Sbjct: 649 TVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYED 708
Query: 158 DVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEIL-FP 215
V Y++ ++ D+G K ++L D D Q + + +++++ F
Sbjct: 709 QVSYTLAITARDNG-----IPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFT 763
Query: 216 E--PIHAIDQDLGVGATLRYELISGNDRKL-FSLDSVNGSLFLEKELDLDAEHNLQANTF 272
I A D+D G+ + Y G+D F ++S +G + + LD + +
Sbjct: 764 SVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRE-----NVAQY 818
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
VL+ A P V + +LD+NDN P FE D +++ + EN P G +V +V ATD
Sbjct: 819 VLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATD 878
Query: 333 KDQGENGEFTYQLDDPK--GAFSIDPRSGWLT 362
D+G N + YQ+ + F +D SG LT
Sbjct: 879 PDEGTNAQIMYQIVEGNIPEVFQLDIFSGELT 910
Score = 70.1 bits (164), Expect = 6e-11
Identities = 97/383 (25%), Positives = 159/383 (41%), Gaps = 53/383 (13%)
Query: 1043 PVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ---PSDTDLPFEISPLT 1099
P F+ Y V E Q + + A D D G+ L Y + S ++ F + P+T
Sbjct: 110 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 169
Query: 1100 GVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLE 1159
G ++ ELDRET+ ++ V A+D+G D ND+ P F E E
Sbjct: 170 GAVTTAEELDRETKSTHVFRVTAQDHG-MPRRSALATLTILVTDTNDHDPVF----EQQE 224
Query: 1160 WKHPEADELSNHNFESVMMIPVYKATIEENAPI--------GTTVAKVFAND-TDFIGNG 1210
+K + L +E V+ + NA I G + ++VF D +
Sbjct: 225 YKESLRENL-EVGYE-VLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRT 282
Query: 1211 NGLI------LYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYEL 1264
G + Y L + Q S+TA + ++V D D + P F + Y +
Sbjct: 283 RGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDND-----NAPQFSEKRYVV 337
Query: 1265 EIEENV--NAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPD 1322
++ E+V APV V+ + + N + Y I++ N R F +D + G L +V D
Sbjct: 338 QVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGN---ARGQFYLDAQTGALDVVSPLD 394
Query: 1323 REVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTN 1382
E Y + VRA Q R P++ + G+ V V++ D+NDN+P F
Sbjct: 395 YETTKEYTLRVRA--QDGGRP------PLSN--VSGL------VTVQVLDINDNAPIFV- 437
Query: 1383 GNRPLVTAIPTTAPFGYQVMQLK 1405
+ P + + P GY V+ ++
Sbjct: 438 -STPFQATVLESVPLGYLVLHVQ 459
Score = 60.9 bits (141), Expect = 3e-08
Identities = 48/175 (27%), Positives = 88/175 (50%), Gaps = 14/175 (8%)
Query: 218 IHAIDQDLGVGATLRYELISGND---RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
+ A D D A + Y L+ G+ ++F +D +G + +D + + ++ L
Sbjct: 242 VRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDRE-----EVESYQL 296
Query: 275 QVQAS-QLNNP-LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V+AS Q +P ++ A V + + D NDN P+F Y + + E++ G VL+V A+D
Sbjct: 297 TVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASD 356
Query: 333 KDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+D+G N Y + + +G F +D ++G L V + LD E ++V A++
Sbjct: 357 RDKGSNAVVHYSIMSGNARGQFYLDAQTGALDV--VSPLDYETTKEYTLRVRAQD 409
Score = 51.6 bits (118), Expect = 2e-05
Identities = 42/132 (31%), Positives = 71/132 (53%), Gaps = 14/132 (10%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G A + Y+++ GN ++F LD +G L +DLD E + +VL +Q
Sbjct: 874 VTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGE--LTALVDLDYEDRPE---YVLVIQ 928
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLP---EFEVDF--YNISIVENLPNGFSVLQVMATD 332
A+ + PL ++A V + LLD NDN P FE+ F Y + + P G ++ +V A D
Sbjct: 929 AT--SAPL-VSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGG-AIGRVPAHD 984
Query: 333 KDQGENGEFTYQ 344
D ++ ++++
Sbjct: 985 PDISDSLTYSFE 996
Score = 48.4 bits (110), Expect = 2e-04
Identities = 30/87 (34%), Positives = 46/87 (52%), Gaps = 7/87 (8%)
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD---DPKG--AFSIDPRS 358
P+F+ Y ++ EN P G V + A D D+GE G Y +D D + FS+DP +
Sbjct: 110 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 169
Query: 359 GWLTVRNQTVLDREAHSSLRMKVYAKE 385
G +T + LDRE S+ +V A++
Sbjct: 170 GAVTTAEE--LDRETKSTHVFRVTAQD 194
Score = 39.5 bits (88), Expect = 0.091
Identities = 29/91 (31%), Positives = 49/91 (53%), Gaps = 10/91 (10%)
Query: 439 LMSFVNVEVTLLDANDNNPVF----VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGM 494
L+S V V LLD NDN PV + N Y + +S++ G IG+V A DPD+ +
Sbjct: 934 LVSRATVHVRLLDRNDNPPVLGNFEILFNNY-VTNRSSSFPGGAIGRVPAHDPDISDS-- 990
Query: 495 VLYDLQRTSNLTITSPFKINPNTGTVSVAES 525
+ Y +R + L++ +N +TG + ++ +
Sbjct: 991 LTYSFERGNELSLV---LLNASTGELKLSRA 1018
Score = 36.7 bits (81), Expect = 0.64
Identities = 25/60 (41%), Positives = 35/60 (58%), Gaps = 4/60 (6%)
Query: 144 IRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMA 203
+ A DRDK + N+ VHYSI+SGN G F L+ + L + LDY+ KE+ L + A
Sbjct: 352 VTASDRDKGS--NAVVHYSIMSGNARGQFYLD-AQTGALDVVSPLDYET-TKEYTLRVRA 407
>AL390252-1|CAI13170.1| 2923|Homo sapiens cadherin, EGF LAG seven-pass
G-type receptor 2 (flamingo homolog, Drosophila) protein.
Length = 2923
Score = 134 bits (324), Expect = 2e-30
Identities = 137/469 (29%), Positives = 213/469 (45%), Gaps = 41/469 (8%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L + +V VT+LD NDNNP F Y + +A VGT + V AVD D + ++ Y
Sbjct: 590 LTASASVSVTVLDVNDNNPTFTQPE-YTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQ 646
Query: 499 LQRTSNLTITSPFKINPNTG--TVSVAESPI---LEGRHALFVEASDQPANPSERRYSLA 553
+ TS T + F I +G VS+A P+ LE ++ L V ASD R A
Sbjct: 647 I--TSGNT-RNRFSITSQSGGGLVSLA-LPLDYKLERQYVLAVTASDGT------RQDTA 696
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHG 613
+ + VT P F + Y V + GT+V I D E + + +
Sbjct: 697 QIVVNVTDANTHR----PVFQSSHYTVNVNEDRPAGTTVVLISATD--EDTGENARITYF 750
Query: 614 YEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA--NLSIVTNATVHVVDVN 670
E+ +P F ++ +G +T +L ++ Y A+ ++N S T + V DVN
Sbjct: 751 MEDSIPQFRIDADTGAVTTQAELDYEDQVSYTL-AITARDNGIPQKSDTTYLEILVNDVN 809
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
D L+ ++ ++ ++ ++ QI T+ S G V + D D
Sbjct: 810 DNAPQFLRDSYQGSVY--EDVPPFTSVLQISATDRDS---GLNGRVFYTFQGGDDGDGDF 864
Query: 731 AI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
+ + G + T + LDRE Y + A +KG+ +VT+ + D NDNPPVFE
Sbjct: 865 IVESTSGIVRTLRRLDRENVAQYVLRAYA-VDKGMPPARTPMEVTVTVLDVNDNPPVFEQ 923
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTGVVKF 848
++ F+ ENS IG + + ATD DEGTNA MY + G E+F +D +G +
Sbjct: 924 DEFDVFVEENSPIGLAVAR---VTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTA 980
Query: 849 IGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIE 897
+ D LD E + Y L ++ + L S A + + + D NDN P E
Sbjct: 981 LVD-LDYEDRPEYVL-VIQATSAPLVSRATVHVRLLDRNDNPPVLGNFE 1027
Score = 128 bits (310), Expect = 1e-28
Identities = 128/477 (26%), Positives = 208/477 (43%), Gaps = 32/477 (6%)
Query: 457 PVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPN 516
P F P + Y+ ++ N GT + ++A+DPD G+ G + Y + + F ++P
Sbjct: 179 PQFQPPS-YQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPV 237
Query: 517 TGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIPDFM 574
TG V+ AE E + H V A D + RR +LA +TI V T N D P F
Sbjct: 238 TGAVTTAEELDRETKSTHVFRVTAQD---HGMPRRSALATLTILV---TDTNDHD-PVFE 290
Query: 575 GAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVP---FAVEERSGVI 629
Y+ + N+ +G V +R DA ++ Y LL G G P F ++ RSGVI
Sbjct: 291 QQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEG-SGGSPSEVFEIDPRSGVI 349
Query: 630 TVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVK 689
+ R Y A + + + + V D+ + + + V+
Sbjct: 350 RTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVR 409
Query: 690 ENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKR 749
E+ A + S V + I + A+ G + PLD E
Sbjct: 410 EDVTPGA--PVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETT 467
Query: 750 DVYRMTVIA-EFNKGVISG-AGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIK 807
Y + V A + + +S +G+ VT+ + D NDN P+F ++ ++E+ +G +
Sbjct: 468 KEYTLRVRAQDGGRPPLSNVSGL--VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVL 525
Query: 808 MDNIIKATDADEGTNALFMYTLFGEGKEM-FDVDENTGVVKFIGDSLDREKKIMYKLSLV 866
++A DAD G NA Y L G G + F ++ TG + + LDRE+ Y +
Sbjct: 526 H---VQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWIS-VAAELDREEVDFYSFGVE 581
Query: 867 ARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
ARD G L++ A + + + D NDN P F Q E VR++ + + GT+ T+ V
Sbjct: 582 ARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYT--VRLNEDAAV-GTSVVTVSAV 635
Score = 124 bits (299), Expect = 2e-27
Identities = 125/471 (26%), Positives = 198/471 (42%), Gaps = 38/471 (8%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V +LD NDN P+FV S ++ ++ + +G ++ V+A+D D G N + Y R +
Sbjct: 491 VTVQVLDINDNAPIFV-STPFQATVLESVPLGYLVLHVQAIDADAGDNARLEY---RLAG 546
Query: 505 LTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
+ PF IN TG +SVA E ++ VEA D S++V ++V
Sbjct: 547 VGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDN 606
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAV 622
P F Y + + +GTSV + D + ++Y + G F++
Sbjct: 607 N-------PTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRN-RFSI 658
Query: 623 EERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHS 682
+SG V L + + + V+V D N R V + +H
Sbjct: 659 TSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPV-FQSSHY 717
Query: 683 PIIFHVKENSAGAAIGQIFHTNMSSIYGNGTG-NVRFLIANQQDVTDDIAIAEDGTIFTQ 741
+ + ++ AG + I T+ TG N R + + A+ G + TQ
Sbjct: 718 TVNVN-EDRPAGTTVVLISATD------EDTGENARITYFMEDSIPQFRIDADTGAVTTQ 770
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
LD E + Y + + A N G+ + + I + D NDN P F +Y+G + E+
Sbjct: 771 AELDYEDQVSYTLAITARDN-GIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVP 829
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFG--EGKEMFDVDENTGVVKFIGDSLDREKKI 859
T + I ATD D G N YT G +G F V+ +G+V+ + LDRE
Sbjct: 830 PFTSVLQ---ISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTL-RRLDRENVA 885
Query: 860 MYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ------IEENSKV 902
Y L A D G + E+ + + D NDN P F Q +EENS +
Sbjct: 886 QYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPI 936
Score = 117 bits (282), Expect = 3e-25
Identities = 178/731 (24%), Positives = 298/731 (40%), Gaps = 104/731 (14%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V +++ D NDN P F Y ++ + G + +V A D D G N +V Y + +
Sbjct: 385 VFLSVEDDNDNAPQFSEKR-YVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGN- 442
Query: 505 LTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLAVVTIEVTR 561
F ++ TG + V SP+ + L V A D P L VT++V
Sbjct: 443 --ARGQFYLDAQTGALDVV-SPLDYETTKEYTLRVRAQDGGRPPLSNVSGL--VTVQVL- 496
Query: 562 GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDL-LHGYEEGVPF 620
+ P F+ P++ V +V +G V ++ DA ++ + L G PF
Sbjct: 497 ---DINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPF 553
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDERGVLLKG 679
+ +G I+V +L R Y F A L+ + +V V+DVND +
Sbjct: 554 TINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQP 613
Query: 680 AHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIA--NQQDVTDDIAIAEDGT 737
++ V+ N AA+G T +S++ + + + I N ++ + + G
Sbjct: 614 EYT-----VRLNE-DAAVGTSVVT-VSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGL 666
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
+ PLD + Y + V A + G Q+ + + D N + PVF+ + Y +
Sbjct: 667 VSLALPLDYKLERQYVLAVTA--SDGTRQDTA--QIVVNVTDANTHRPVFQSSHYTVNVN 722
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREK 857
E+ GT + + I ATD D G EN + F+ DS+ + +
Sbjct: 723 EDRPAGTTVVL---ISATDEDTG--------------------ENARITYFMEDSIPQFR 759
Query: 858 KIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFT 917
+ DTG ++++AEL D D Q+ + R+ + + T
Sbjct: 760 --------IDADTGAVTTQAEL-----DYED------QVSYTLAITA-RDNGIPQKSDTT 799
Query: 918 IIEVKPKNKFALDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEF 970
+E+ DV+ P FL + E++P T++++++A D DSGLNG++ Y F
Sbjct: 800 YLEI-----LVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTF 854
Query: 971 NSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LN 1026
D F++ G V R L E+ ++ L A+D G
Sbjct: 855 QGG-----DDGDGD-------FIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPAR 902
Query: 1027 DNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQP 1086
+ V V V DVND+ PVF++ ++ VEE + +V ATD D G NA + Y I
Sbjct: 903 TPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVE 962
Query: 1087 SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+ F++ +G L+ +LD E +Y+L + A D ND
Sbjct: 963 GNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQA----TSAPLVSRATVHVRLLDRND 1018
Query: 1147 NSPKFYAFDEL 1157
N P F+ L
Sbjct: 1019 NPPVLGNFEIL 1029
Score = 106 bits (254), Expect = 7e-22
Identities = 116/432 (26%), Positives = 188/432 (43%), Gaps = 59/432 (13%)
Query: 929 LDVDQLGPLFLIPE-------NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LDV+ P F PE + +GT+++ ++A+D D+ + I Y+ S
Sbjct: 601 LDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSG-------- 650
Query: 982 SADALEVKRYFVINERHGHVIVARSLPP----ESEFRLNISALDGGNLNDNISVRVFVKD 1037
+ F I + G +V+ +LP E ++ L ++A DG D + V V D
Sbjct: 651 -----NTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTR-QDTAQIVVNVTD 704
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISP 1097
N H PVF+ + Y NV E + + + ATD D G+NA +TYF++ D+ F I
Sbjct: 705 ANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFME--DSIPQFRIDA 762
Query: 1098 LTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDEL 1157
TG ++ ELD E + Y L + ARDNG DVNDN+P+F D
Sbjct: 763 DTGAVTTQAELDYEDQVSYTLAITARDNG-IPQKSDTTYLEILVNDVNDNAPQFLR-DSY 820
Query: 1158 LEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYS 1217
+ + F SV+ I N + T D DFI I+ +
Sbjct: 821 QGSVYEDVPP-----FTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRT 875
Query: 1218 LPQRKNQQNL------------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELE 1265
L +R +++N+ G+P + + VTV DV D + PVF +++
Sbjct: 876 L-RRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVND-----NPPVFEQDEFDVF 929
Query: 1266 IEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDR 1323
+EEN + + + T+ E N ++ Y I+ N I F +D +G L + D
Sbjct: 930 VEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGN---IPEVFQLDIFSGELTALVDLDY 986
Query: 1324 EVKDTYEVIVRA 1335
E + Y ++++A
Sbjct: 987 EDRPEYVLVIQA 998
Score = 99.5 bits (237), Expect = 8e-20
Identities = 126/488 (25%), Positives = 203/488 (41%), Gaps = 59/488 (12%)
Query: 906 RETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQ 965
R+ T + V+ N A + + + E++ G ++++ A D D G N
Sbjct: 374 RDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAV 433
Query: 966 IRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGG 1023
+ Y S +S +A + F ++ + G + V L E+ E+ L + A DGG
Sbjct: 434 VHY----------SIMSGNA---RGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGG 480
Query: 1024 NLN-DNIS--VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANL 1080
N+S V V V D+ND+ P+F T + V E+ ++ V A DAD G NA L
Sbjct: 481 RPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARL 540
Query: 1081 TYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXX 1140
Y + D PF I+ TG +SV ELDRE D Y V ARD+G
Sbjct: 541 EYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHG-TPALTASASVSVT 599
Query: 1141 XXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVF 1200
DVNDN+P F PE N + +V V + ++ +A T
Sbjct: 600 VLDVNDNNPTF---------TQPEYTVRLNED-AAVGTSVVTVSAVDRDAHSVITYQITS 649
Query: 1201 ANDTDFIG----NGNGLILYSLP-QRKNQQNLGLPSLSSTAILMVTVADVPDEVEM-SDK 1254
N + +G GL+ +LP K ++ L +S T V + + + +
Sbjct: 650 GNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHR 709
Query: 1255 PVFISRYYELEIEENVNAPVELVSLNLTEH--YENFKMRYYILNENDTDIRRTFVIDPRN 1312
PVF S +Y + + E+ A +V ++ T+ EN ++ Y++ D F ID
Sbjct: 710 PVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFM-----EDSIPQFRIDADT 764
Query: 1313 GTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKD 1372
G + D E + +Y + + A +P + T Y + + + D
Sbjct: 765 GAVTTQAELDYEDQVSYTLAITAR----DNGIPQ----------KSDTTY---LEILVND 807
Query: 1373 VNDNSPKF 1380
VNDN+P+F
Sbjct: 808 VNDNAPQF 815
Score = 95.5 bits (227), Expect = 1e-18
Identities = 86/319 (26%), Positives = 145/319 (45%), Gaps = 36/319 (11%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTP--------------TGEKAFI-FLIAPIGPS 127
VTV + D+NDN PIF+ TP+ TV E P G+ A + + +A +G
Sbjct: 491 VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHD 550
Query: 128 LTIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKV 187
P T+ G DR++ D + V D G AL +S + + V
Sbjct: 551 F--PFTINNGTGWISVAAELDREEV-----DFYSFGVEARDHGTPALTASASVSVTVLDV 603
Query: 188 LDYDAGDKEFQLVI-MASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSL 246
D + + + + + + ++ + A+D+D + + Y++ SGN R FS+
Sbjct: 604 NDNNPTFTQPEYTVRLNEDAAVGTSVV---TVSAVDRD--AHSVITYQITSGNTRNRFSI 658
Query: 247 DSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF 306
S +G + L LD + Q +VL V AS + + A++ + + D N + P F
Sbjct: 659 TSQSGGGLVSLALPLDYKLERQ---YVLAVTAS---DGTRQDTAQIVVNVTDANTHRPVF 712
Query: 307 EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQ 366
+ Y +++ E+ P G +V+ + ATD+D GEN TY ++D F ID +G V Q
Sbjct: 713 QSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTG--AVTTQ 770
Query: 367 TVLDREAHSSLRMKVYAKE 385
LD E S + + A++
Sbjct: 771 AELDYEDQVSYTLAITARD 789
Score = 87.4 bits (207), Expect = 3e-16
Identities = 62/176 (35%), Positives = 85/176 (48%), Gaps = 15/176 (8%)
Query: 218 IHAIDQDLGVGATLRYE---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
+ AID D G L Y L + FSLD V G++ +ELD + + +T V
Sbjct: 203 LRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDRETK-----STHVF 257
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+V A P ++A A + I + D ND+ P FE Y S+ ENL G+ VL V ATD D
Sbjct: 258 RVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGD 317
Query: 335 QGENGEFTYQL-----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N Y+L P F IDPRSG +R + +DRE S ++ V A +
Sbjct: 318 APPNANILYRLLEGSGGSPSEVFEIDPRSG--VIRTRGPVDREEVESYQLTVEASD 371
Score = 86.2 bits (204), Expect = 8e-16
Identities = 115/460 (25%), Positives = 191/460 (41%), Gaps = 56/460 (12%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN P GT + L A+D D G G++ Y ++ + S+ + ++F ++ G
Sbjct: 190 VPENQPAGTPVASLRAIDPDEGEAGRLEYTMDA---LFDSRSN-------QFFSLDPVTG 239
Query: 1000 HVIVARSLPPESEFR--LNISALDGGNLNDNI--SVRVFVKDVNDHFPVFKKTWYNFNVE 1055
V A L E++ ++A D G + ++ + V D NDH PVF++ Y ++
Sbjct: 240 AVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLR 299
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP---FEISPLTGVLSVNGELDRET 1112
E + V ATD D NAN+ Y + P FEI P +GV+ G +DRE
Sbjct: 300 ENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREE 359
Query: 1113 EDKYILTVVARDNGXX-XXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKH---PEADEL 1168
+ Y LTV A D G D NDN+P+F +++ + P A L
Sbjct: 360 VESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVL 419
Query: 1169 --SNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQN 1226
+ + + V+ + + NA G D + + R Q+
Sbjct: 420 RVTASDRDKGSNAVVHYSIMSGNAR-GQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQD 478
Query: 1227 LGLPSLSS-TAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL---- 1281
G P LS+ + ++ V V D+ D + P+F+S ++ + E+V P+ + L++
Sbjct: 479 GGRPPLSNVSGLVTVQVLDIND-----NAPIFVSTPFQATVLESV--PLGYLVLHVQAID 531
Query: 1282 TEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYS 1341
+ +N ++ Y + D F I+ G + + DRE D Y V A
Sbjct: 532 ADAGDNARLEYRLAGVGH-DF--PFTINNGTGWISVAAELDREEVDFYSFGVEAR----- 583
Query: 1342 RELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
+ +T V V + DVNDN+P FT
Sbjct: 584 -----------DHGTPALTA-SASVSVTVLDVNDNNPTFT 611
Score = 86.2 bits (204), Expect = 8e-16
Identities = 66/236 (27%), Positives = 109/236 (46%), Gaps = 13/236 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D+D G A + Y ++SGN R F LD+ G+L + LD + + L+V+
Sbjct: 421 VTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYET-----TKEYTLRVR 475
Query: 278 ASQLNNP-LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A P L V +++LD+NDN P F + +++E++P G+ VL V A D D G
Sbjct: 476 AQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAG 535
Query: 337 ENGEFTYQLD--DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
+N Y+L F+I+ +GW++V + LDRE V A++ P++ +
Sbjct: 536 DNARLEYRLAGVGHDFPFTINNGTGWISVAAE--LDREEVDFYSFGVEARDHGTPALTAS 593
Query: 394 FADSQRIAKWRRQPLETNAPLEKTTYVFPD-KVGTKTENIEYYDEQLMSFVNVEVT 448
+ S + P E T + D VGT + D S + ++T
Sbjct: 594 ASVSVTVLDVNDNNPTFTQP-EYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQIT 648
Score = 79.0 bits (186), Expect = 1e-13
Identities = 57/169 (33%), Positives = 88/169 (52%), Gaps = 12/169 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I A D+D G A + Y + + F +D+ G++ + ELD + + + + L +
Sbjct: 734 ISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQVS-----YTLAIT 786
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P K+ +EI + D+NDN P+F D Y S+ E++P SVLQ+ ATD+D G
Sbjct: 787 ARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGL 846
Query: 338 NGE--FTYQ-LDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
NG +T+Q DD G F ++ SG VR LDRE + ++ YA
Sbjct: 847 NGRVFYTFQGGDDGDGDFIVESTSG--IVRTLRRLDRENVAQYVLRAYA 893
Score = 74.5 bits (175), Expect = 3e-12
Identities = 80/332 (24%), Positives = 137/332 (41%), Gaps = 23/332 (6%)
Query: 44 VDSDSPQNVVKFRLGCDFD-EGDDLVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPY 102
+ S S +V L D+ E ++ + A + V + D N + P+F + Y
Sbjct: 658 ITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHY 717
Query: 103 HVTVDELTPTGEKAFIFLIAP--IGPSLTIPLTVPRGLTIFK---DIRAFDRDKPNTPNS 157
V V+E P G + G + I + + F+ D A
Sbjct: 718 TVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYED 777
Query: 158 DVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEIL-FP 215
V Y++ ++ D+G K ++L D D Q + + +++++ F
Sbjct: 778 QVSYTLAITARDNG-----IPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFT 832
Query: 216 E--PIHAIDQDLGVGATLRYELISGNDRKL-FSLDSVNGSLFLEKELDLDAEHNLQANTF 272
I A D+D G+ + Y G+D F ++S +G + + LD + +
Sbjct: 833 SVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRE-----NVAQY 887
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
VL+ A P V + +LD+NDN P FE D +++ + EN P G +V +V ATD
Sbjct: 888 VLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATD 947
Query: 333 KDQGENGEFTYQLDDPK--GAFSIDPRSGWLT 362
D+G N + YQ+ + F +D SG LT
Sbjct: 948 PDEGTNAQIMYQIVEGNIPEVFQLDIFSGELT 979
Score = 70.1 bits (164), Expect = 6e-11
Identities = 97/383 (25%), Positives = 159/383 (41%), Gaps = 53/383 (13%)
Query: 1043 PVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ---PSDTDLPFEISPLT 1099
P F+ Y V E Q + + A D D G+ L Y + S ++ F + P+T
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 1100 GVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLE 1159
G ++ ELDRET+ ++ V A+D+G D ND+ P F E E
Sbjct: 239 GAVTTAEELDRETKSTHVFRVTAQDHG-MPRRSALATLTILVTDTNDHDPVF----EQQE 293
Query: 1160 WKHPEADELSNHNFESVMMIPVYKATIEENAPI--------GTTVAKVFAND-TDFIGNG 1210
+K + L +E V+ + NA I G + ++VF D +
Sbjct: 294 YKESLRENL-EVGYE-VLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRT 351
Query: 1211 NGLI------LYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYEL 1264
G + Y L + Q S+TA + ++V D D + P F + Y +
Sbjct: 352 RGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDND-----NAPQFSEKRYVV 406
Query: 1265 EIEENV--NAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPD 1322
++ E+V APV V+ + + N + Y I++ N R F +D + G L +V D
Sbjct: 407 QVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGN---ARGQFYLDAQTGALDVVSPLD 463
Query: 1323 REVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTN 1382
E Y + VRA Q R P++ + G+ V V++ D+NDN+P F
Sbjct: 464 YETTKEYTLRVRA--QDGGRP------PLSN--VSGL------VTVQVLDINDNAPIFV- 506
Query: 1383 GNRPLVTAIPTTAPFGYQVMQLK 1405
+ P + + P GY V+ ++
Sbjct: 507 -STPFQATVLESVPLGYLVLHVQ 528
Score = 60.9 bits (141), Expect = 3e-08
Identities = 48/175 (27%), Positives = 88/175 (50%), Gaps = 14/175 (8%)
Query: 218 IHAIDQDLGVGATLRYELISGND---RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
+ A D D A + Y L+ G+ ++F +D +G + +D + + ++ L
Sbjct: 311 VRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDRE-----EVESYQL 365
Query: 275 QVQAS-QLNNP-LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V+AS Q +P ++ A V + + D NDN P+F Y + + E++ G VL+V A+D
Sbjct: 366 TVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASD 425
Query: 333 KDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+D+G N Y + + +G F +D ++G L V + LD E ++V A++
Sbjct: 426 RDKGSNAVVHYSIMSGNARGQFYLDAQTGALDV--VSPLDYETTKEYTLRVRAQD 478
Score = 51.6 bits (118), Expect = 2e-05
Identities = 42/132 (31%), Positives = 71/132 (53%), Gaps = 14/132 (10%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G A + Y+++ GN ++F LD +G L +DLD E + +VL +Q
Sbjct: 943 VTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGE--LTALVDLDYEDRPE---YVLVIQ 997
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLP---EFEVDF--YNISIVENLPNGFSVLQVMATD 332
A+ + PL ++A V + LLD NDN P FE+ F Y + + P G ++ +V A D
Sbjct: 998 AT--SAPL-VSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGG-AIGRVPAHD 1053
Query: 333 KDQGENGEFTYQ 344
D ++ ++++
Sbjct: 1054 PDISDSLTYSFE 1065
Score = 48.4 bits (110), Expect = 2e-04
Identities = 30/87 (34%), Positives = 46/87 (52%), Gaps = 7/87 (8%)
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD---DPKG--AFSIDPRS 358
P+F+ Y ++ EN P G V + A D D+GE G Y +D D + FS+DP +
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 359 GWLTVRNQTVLDREAHSSLRMKVYAKE 385
G +T + LDRE S+ +V A++
Sbjct: 239 GAVTTAEE--LDRETKSTHVFRVTAQD 263
Score = 39.5 bits (88), Expect = 0.091
Identities = 29/91 (31%), Positives = 49/91 (53%), Gaps = 10/91 (10%)
Query: 439 LMSFVNVEVTLLDANDNNPVF----VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGM 494
L+S V V LLD NDN PV + N Y + +S++ G IG+V A DPD+ +
Sbjct: 1003 LVSRATVHVRLLDRNDNPPVLGNFEILFNNY-VTNRSSSFPGGAIGRVPAHDPDISDS-- 1059
Query: 495 VLYDLQRTSNLTITSPFKINPNTGTVSVAES 525
+ Y +R + L++ +N +TG + ++ +
Sbjct: 1060 LTYSFERGNELSLV---LLNASTGELKLSRA 1087
Score = 36.7 bits (81), Expect = 0.64
Identities = 25/60 (41%), Positives = 35/60 (58%), Gaps = 4/60 (6%)
Query: 144 IRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMA 203
+ A DRDK + N+ VHYSI+SGN G F L+ + L + LDY+ KE+ L + A
Sbjct: 421 VTASDRDKGS--NAVVHYSIMSGNARGQFYLD-AQTGALDVVSPLDYET-TKEYTLRVRA 476
>AF234887-1|AAG00080.1| 2923|Homo sapiens FLAMINGO 1 protein.
Length = 2923
Score = 134 bits (324), Expect = 2e-30
Identities = 137/469 (29%), Positives = 213/469 (45%), Gaps = 41/469 (8%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L + +V VT+LD NDNNP F Y + +A VGT + V AVD D + ++ Y
Sbjct: 590 LTASASVSVTVLDVNDNNPTFTQPE-YTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQ 646
Query: 499 LQRTSNLTITSPFKINPNTG--TVSVAESPI---LEGRHALFVEASDQPANPSERRYSLA 553
+ TS T + F I +G VS+A P+ LE ++ L V ASD R A
Sbjct: 647 I--TSGNT-RNRFSITSQSGGGLVSLA-LPLDYKLERQYVLAVTASDGT------RQDTA 696
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHG 613
+ + VT P F + Y V + GT+V I D E + + +
Sbjct: 697 QIVVNVTDANTHR----PVFQSSHYTVNVNEDRPAGTTVVLISATD--EDTGENARITYF 750
Query: 614 YEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA--NLSIVTNATVHVVDVN 670
E+ +P F ++ +G +T +L ++ Y A+ ++N S T + V DVN
Sbjct: 751 MEDSIPQFRIDADTGAVTTQAELDYEDQVSYTL-AITARDNGIPQKSDTTYLEILVNDVN 809
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
D L+ ++ ++ ++ ++ QI T+ S G V + D D
Sbjct: 810 DNAPQFLRDSYQGSVY--EDVPPFTSVLQISATDRDS---GLNGRVFYTFQGGDDGDGDF 864
Query: 731 AI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
+ + G + T + LDRE Y + A +KG+ +VT+ + D NDNPPVFE
Sbjct: 865 IVESTSGIVRTLRRLDRENVAQYVLRAYA-VDKGMPPARTPMEVTVTVLDVNDNPPVFEQ 923
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTGVVKF 848
++ F+ ENS IG + + ATD DEGTNA MY + G E+F +D +G +
Sbjct: 924 DEFDVFVEENSPIGLAVAR---VTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTA 980
Query: 849 IGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIE 897
+ D LD E + Y L ++ + L S A + + + D NDN P E
Sbjct: 981 LVD-LDYEDRPEYVL-VIQATSAPLVSRATVHVRLLDRNDNPPVLGNFE 1027
Score = 128 bits (310), Expect = 1e-28
Identities = 128/477 (26%), Positives = 208/477 (43%), Gaps = 32/477 (6%)
Query: 457 PVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPN 516
P F P + Y+ ++ N GT + ++A+DPD G+ G + Y + + F ++P
Sbjct: 179 PQFQPPS-YQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPV 237
Query: 517 TGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIPDFM 574
TG V+ AE E + H V A D + RR +LA +TI V T N D P F
Sbjct: 238 TGAVTTAEELDRETKSTHVFRVTAQD---HGMPRRSALATLTILV---TDTNDHD-PVFE 290
Query: 575 GAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVP---FAVEERSGVI 629
Y+ + N+ +G V +R DA ++ Y LL G G P F ++ RSGVI
Sbjct: 291 QQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEG-SGGSPSEVFEIDPRSGVI 349
Query: 630 TVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVK 689
+ R Y A + + + + V D+ + + + V+
Sbjct: 350 RTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVR 409
Query: 690 ENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKR 749
E+ A + S V + I + A+ G + PLD E
Sbjct: 410 EDVTPGA--PVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETT 467
Query: 750 DVYRMTVIA-EFNKGVISG-AGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIK 807
Y + V A + + +S +G+ VT+ + D NDN P+F ++ ++E+ +G +
Sbjct: 468 KEYTLRVRAQDGGRPPLSNVSGL--VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVL 525
Query: 808 MDNIIKATDADEGTNALFMYTLFGEGKEM-FDVDENTGVVKFIGDSLDREKKIMYKLSLV 866
++A DAD G NA Y L G G + F ++ TG + + LDRE+ Y +
Sbjct: 526 H---VQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWIS-VAAELDREEVDFYSFGVE 581
Query: 867 ARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
ARD G L++ A + + + D NDN P F Q E VR++ + + GT+ T+ V
Sbjct: 582 ARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYT--VRLNEDAAV-GTSVVTVSAV 635
Score = 124 bits (299), Expect = 2e-27
Identities = 125/471 (26%), Positives = 198/471 (42%), Gaps = 38/471 (8%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V +LD NDN P+FV S ++ ++ + +G ++ V+A+D D G N + Y R +
Sbjct: 491 VTVQVLDINDNAPIFV-STPFQATVLESVPLGYLVLHVQAIDADAGDNARLEY---RLAG 546
Query: 505 LTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
+ PF IN TG +SVA E ++ VEA D S++V ++V
Sbjct: 547 VGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDN 606
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAV 622
P F Y + + +GTSV + D + ++Y + G F++
Sbjct: 607 N-------PTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRN-RFSI 658
Query: 623 EERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHS 682
+SG V L + + + V+V D N R V + +H
Sbjct: 659 TSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPV-FQSSHY 717
Query: 683 PIIFHVKENSAGAAIGQIFHTNMSSIYGNGTG-NVRFLIANQQDVTDDIAIAEDGTIFTQ 741
+ + ++ AG + I T+ TG N R + + A+ G + TQ
Sbjct: 718 TVNVN-EDRPAGTTVVLISATD------EDTGENARITYFMEDSIPQFRIDADTGAVTTQ 770
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
LD E + Y + + A N G+ + + I + D NDN P F +Y+G + E+
Sbjct: 771 AELDYEDQVSYTLAITARDN-GIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVP 829
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFG--EGKEMFDVDENTGVVKFIGDSLDREKKI 859
T + I ATD D G N YT G +G F V+ +G+V+ + LDRE
Sbjct: 830 PFTSVLQ---ISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTL-RRLDRENVA 885
Query: 860 MYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ------IEENSKV 902
Y L A D G + E+ + + D NDN P F Q +EENS +
Sbjct: 886 QYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPI 936
Score = 117 bits (282), Expect = 3e-25
Identities = 178/731 (24%), Positives = 298/731 (40%), Gaps = 104/731 (14%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V +++ D NDN P F Y ++ + G + +V A D D G N +V Y + +
Sbjct: 385 VFLSVEDDNDNAPQFSEKR-YVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGN- 442
Query: 505 LTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLAVVTIEVTR 561
F ++ TG + V SP+ + L V A D P L VT++V
Sbjct: 443 --ARGQFYLDAQTGALDVV-SPLDYETTKEYTLRVRAQDGGRPPLSNVSGL--VTVQVL- 496
Query: 562 GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDL-LHGYEEGVPF 620
+ P F+ P++ V +V +G V ++ DA ++ + L G PF
Sbjct: 497 ---DINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPF 553
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDERGVLLKG 679
+ +G I+V +L R Y F A L+ + +V V+DVND +
Sbjct: 554 TINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQP 613
Query: 680 AHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIA--NQQDVTDDIAIAEDGT 737
++ V+ N AA+G T +S++ + + + I N ++ + + G
Sbjct: 614 EYT-----VRLNE-DAAVGTSVVT-VSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGL 666
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
+ PLD + Y + V A + G Q+ + + D N + PVF+ + Y +
Sbjct: 667 VSLALPLDYKLERQYVLAVTA--SDGTRQDTA--QIVVNVTDANTHRPVFQSSHYTVNVN 722
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREK 857
E+ GT + + I ATD D G EN + F+ DS+ + +
Sbjct: 723 EDRPAGTTVVL---ISATDEDTG--------------------ENARITYFMEDSIPQFR 759
Query: 858 KIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFT 917
+ DTG ++++AEL D D Q+ + R+ + + T
Sbjct: 760 --------IDADTGAVTTQAEL-----DYED------QVSYTLAITA-RDNGIPQKSDTT 799
Query: 918 IIEVKPKNKFALDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEF 970
+E+ DV+ P FL + E++P T++++++A D DSGLNG++ Y F
Sbjct: 800 YLEI-----LVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTF 854
Query: 971 NSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LN 1026
D F++ G V R L E+ ++ L A+D G
Sbjct: 855 QGG-----DDGDGD-------FIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPAR 902
Query: 1027 DNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQP 1086
+ V V V DVND+ PVF++ ++ VEE + +V ATD D G NA + Y I
Sbjct: 903 TPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVE 962
Query: 1087 SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+ F++ +G L+ +LD E +Y+L + A D ND
Sbjct: 963 GNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQA----TSAPLVSRATVHVRLLDRND 1018
Query: 1147 NSPKFYAFDEL 1157
N P F+ L
Sbjct: 1019 NPPVLGNFEIL 1029
Score = 106 bits (254), Expect = 7e-22
Identities = 116/432 (26%), Positives = 188/432 (43%), Gaps = 59/432 (13%)
Query: 929 LDVDQLGPLFLIPE-------NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LDV+ P F PE + +GT+++ ++A+D D+ + I Y+ S
Sbjct: 601 LDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSG-------- 650
Query: 982 SADALEVKRYFVINERHGHVIVARSLPP----ESEFRLNISALDGGNLNDNISVRVFVKD 1037
+ F I + G +V+ +LP E ++ L ++A DG D + V V D
Sbjct: 651 -----NTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTR-QDTAQIVVNVTD 704
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISP 1097
N H PVF+ + Y NV E + + + ATD D G+NA +TYF++ D+ F I
Sbjct: 705 ANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFME--DSIPQFRIDA 762
Query: 1098 LTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDEL 1157
TG ++ ELD E + Y L + ARDNG DVNDN+P+F D
Sbjct: 763 DTGAVTTQAELDYEDQVSYTLAITARDNG-IPQKSDTTYLEILVNDVNDNAPQFLR-DSY 820
Query: 1158 LEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYS 1217
+ + F SV+ I N + T D DFI I+ +
Sbjct: 821 QGSVYEDVPP-----FTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRT 875
Query: 1218 LPQRKNQQNL------------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELE 1265
L +R +++N+ G+P + + VTV DV D + PVF +++
Sbjct: 876 L-RRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVND-----NPPVFEQDEFDVF 929
Query: 1266 IEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDR 1323
+EEN + + + T+ E N ++ Y I+ N I F +D +G L + D
Sbjct: 930 VEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGN---IPEVFQLDIFSGELTALVDLDY 986
Query: 1324 EVKDTYEVIVRA 1335
E + Y ++++A
Sbjct: 987 EDRPEYVLVIQA 998
Score = 99.5 bits (237), Expect = 8e-20
Identities = 126/488 (25%), Positives = 203/488 (41%), Gaps = 59/488 (12%)
Query: 906 RETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQ 965
R+ T + V+ N A + + + E++ G ++++ A D D G N
Sbjct: 374 RDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAV 433
Query: 966 IRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGG 1023
+ Y S +S +A + F ++ + G + V L E+ E+ L + A DGG
Sbjct: 434 VHY----------SIMSGNA---RGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGG 480
Query: 1024 NLN-DNIS--VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANL 1080
N+S V V V D+ND+ P+F T + V E+ ++ V A DAD G NA L
Sbjct: 481 RPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARL 540
Query: 1081 TYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXX 1140
Y + D PF I+ TG +SV ELDRE D Y V ARD+G
Sbjct: 541 EYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHG-TPALTASASVSVT 599
Query: 1141 XXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVF 1200
DVNDN+P F PE N + +V V + ++ +A T
Sbjct: 600 VLDVNDNNPTF---------TQPEYTVRLNED-AAVGTSVVTVSAVDRDAHSVITYQITS 649
Query: 1201 ANDTDFIG----NGNGLILYSLP-QRKNQQNLGLPSLSSTAILMVTVADVPDEVEM-SDK 1254
N + +G GL+ +LP K ++ L +S T V + + + +
Sbjct: 650 GNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHR 709
Query: 1255 PVFISRYYELEIEENVNAPVELVSLNLTEH--YENFKMRYYILNENDTDIRRTFVIDPRN 1312
PVF S +Y + + E+ A +V ++ T+ EN ++ Y++ D F ID
Sbjct: 710 PVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFM-----EDSIPQFRIDADT 764
Query: 1313 GTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKD 1372
G + D E + +Y + + A +P + T Y + + + D
Sbjct: 765 GAVTTQAELDYEDQVSYTLAITAR----DNGIPQ----------KSDTTY---LEILVND 807
Query: 1373 VNDNSPKF 1380
VNDN+P+F
Sbjct: 808 VNDNAPQF 815
Score = 95.5 bits (227), Expect = 1e-18
Identities = 86/319 (26%), Positives = 145/319 (45%), Gaps = 36/319 (11%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTP--------------TGEKAFI-FLIAPIGPS 127
VTV + D+NDN PIF+ TP+ TV E P G+ A + + +A +G
Sbjct: 491 VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHD 550
Query: 128 LTIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKV 187
P T+ G DR++ D + V D G AL +S + + V
Sbjct: 551 F--PFTINNGTGWISVAAELDREEV-----DFYSFGVEARDHGTPALTASASVSVTVLDV 603
Query: 188 LDYDAGDKEFQLVI-MASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSL 246
D + + + + + + ++ + A+D+D + + Y++ SGN R FS+
Sbjct: 604 NDNNPTFTQPEYTVRLNEDAAVGTSVV---TVSAVDRD--AHSVITYQITSGNTRNRFSI 658
Query: 247 DSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF 306
S +G + L LD + Q +VL V AS + + A++ + + D N + P F
Sbjct: 659 TSQSGGGLVSLALPLDYKLERQ---YVLAVTAS---DGTRQDTAQIVVNVTDANTHRPVF 712
Query: 307 EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQ 366
+ Y +++ E+ P G +V+ + ATD+D GEN TY ++D F ID +G V Q
Sbjct: 713 QSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTG--AVTTQ 770
Query: 367 TVLDREAHSSLRMKVYAKE 385
LD E S + + A++
Sbjct: 771 AELDYEDQVSYTLAITARD 789
Score = 87.4 bits (207), Expect = 3e-16
Identities = 62/176 (35%), Positives = 85/176 (48%), Gaps = 15/176 (8%)
Query: 218 IHAIDQDLGVGATLRYE---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
+ AID D G L Y L + FSLD V G++ +ELD + + +T V
Sbjct: 203 LRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDRETK-----STHVF 257
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+V A P ++A A + I + D ND+ P FE Y S+ ENL G+ VL V ATD D
Sbjct: 258 RVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGD 317
Query: 335 QGENGEFTYQL-----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N Y+L P F IDPRSG +R + +DRE S ++ V A +
Sbjct: 318 APPNANILYRLLEGSGGSPSEVFEIDPRSG--VIRTRGPVDREEVESYQLTVEASD 371
Score = 86.2 bits (204), Expect = 8e-16
Identities = 115/460 (25%), Positives = 191/460 (41%), Gaps = 56/460 (12%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN P GT + L A+D D G G++ Y ++ + S+ + ++F ++ G
Sbjct: 190 VPENQPAGTPVASLRAIDPDEGEAGRLEYTMDA---LFDSRSN-------QFFSLDPVTG 239
Query: 1000 HVIVARSLPPESEFR--LNISALDGGNLNDNI--SVRVFVKDVNDHFPVFKKTWYNFNVE 1055
V A L E++ ++A D G + ++ + V D NDH PVF++ Y ++
Sbjct: 240 AVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLR 299
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP---FEISPLTGVLSVNGELDRET 1112
E + V ATD D NAN+ Y + P FEI P +GV+ G +DRE
Sbjct: 300 ENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREE 359
Query: 1113 EDKYILTVVARDNGXX-XXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKH---PEADEL 1168
+ Y LTV A D G D NDN+P+F +++ + P A L
Sbjct: 360 VESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVL 419
Query: 1169 --SNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQN 1226
+ + + V+ + + NA G D + + R Q+
Sbjct: 420 RVTASDRDKGSNAVVHYSIMSGNAR-GQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQD 478
Query: 1227 LGLPSLSS-TAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL---- 1281
G P LS+ + ++ V V D+ D + P+F+S ++ + E+V P+ + L++
Sbjct: 479 GGRPPLSNVSGLVTVQVLDIND-----NAPIFVSTPFQATVLESV--PLGYLVLHVQAID 531
Query: 1282 TEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYS 1341
+ +N ++ Y + D F I+ G + + DRE D Y V A
Sbjct: 532 ADAGDNARLEYRLAGVGH-DF--PFTINNGTGWISVAAELDREEVDFYSFGVEAR----- 583
Query: 1342 RELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
+ +T V V + DVNDN+P FT
Sbjct: 584 -----------DHGTPALTA-SASVSVTVLDVNDNNPTFT 611
Score = 86.2 bits (204), Expect = 8e-16
Identities = 66/236 (27%), Positives = 109/236 (46%), Gaps = 13/236 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D+D G A + Y ++SGN R F LD+ G+L + LD + + L+V+
Sbjct: 421 VTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYET-----TKEYTLRVR 475
Query: 278 ASQLNNP-LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A P L V +++LD+NDN P F + +++E++P G+ VL V A D D G
Sbjct: 476 AQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAG 535
Query: 337 ENGEFTYQLD--DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
+N Y+L F+I+ +GW++V + LDRE V A++ P++ +
Sbjct: 536 DNARLEYRLAGVGHDFPFTINNGTGWISVAAE--LDREEVDFYSFGVEARDHGTPALTAS 593
Query: 394 FADSQRIAKWRRQPLETNAPLEKTTYVFPD-KVGTKTENIEYYDEQLMSFVNVEVT 448
+ S + P E T + D VGT + D S + ++T
Sbjct: 594 ASVSVTVLDVNDNNPTFTQP-EYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQIT 648
Score = 79.0 bits (186), Expect = 1e-13
Identities = 57/169 (33%), Positives = 88/169 (52%), Gaps = 12/169 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I A D+D G A + Y + + F +D+ G++ + ELD + + + + L +
Sbjct: 734 ISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQVS-----YTLAIT 786
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P K+ +EI + D+NDN P+F D Y S+ E++P SVLQ+ ATD+D G
Sbjct: 787 ARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGL 846
Query: 338 NGE--FTYQ-LDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
NG +T+Q DD G F ++ SG VR LDRE + ++ YA
Sbjct: 847 NGRVFYTFQGGDDGDGDFIVESTSG--IVRTLRRLDRENVAQYVLRAYA 893
Score = 74.5 bits (175), Expect = 3e-12
Identities = 80/332 (24%), Positives = 137/332 (41%), Gaps = 23/332 (6%)
Query: 44 VDSDSPQNVVKFRLGCDFD-EGDDLVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPY 102
+ S S +V L D+ E ++ + A + V + D N + P+F + Y
Sbjct: 658 ITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHY 717
Query: 103 HVTVDELTPTGEKAFIFLIAP--IGPSLTIPLTVPRGLTIFK---DIRAFDRDKPNTPNS 157
V V+E P G + G + I + + F+ D A
Sbjct: 718 TVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYED 777
Query: 158 DVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEIL-FP 215
V Y++ ++ D+G K ++L D D Q + + +++++ F
Sbjct: 778 QVSYTLAITARDNG-----IPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFT 832
Query: 216 E--PIHAIDQDLGVGATLRYELISGNDRKL-FSLDSVNGSLFLEKELDLDAEHNLQANTF 272
I A D+D G+ + Y G+D F ++S +G + + LD + +
Sbjct: 833 SVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRE-----NVAQY 887
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
VL+ A P V + +LD+NDN P FE D +++ + EN P G +V +V ATD
Sbjct: 888 VLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATD 947
Query: 333 KDQGENGEFTYQLDDPK--GAFSIDPRSGWLT 362
D+G N + YQ+ + F +D SG LT
Sbjct: 948 PDEGTNAQIMYQIVEGNIPEVFQLDIFSGELT 979
Score = 70.1 bits (164), Expect = 6e-11
Identities = 97/383 (25%), Positives = 159/383 (41%), Gaps = 53/383 (13%)
Query: 1043 PVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ---PSDTDLPFEISPLT 1099
P F+ Y V E Q + + A D D G+ L Y + S ++ F + P+T
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 1100 GVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLE 1159
G ++ ELDRET+ ++ V A+D+G D ND+ P F E E
Sbjct: 239 GAVTTAEELDRETKSTHVFRVTAQDHG-MPRRSALATLTILVTDTNDHDPVF----EQQE 293
Query: 1160 WKHPEADELSNHNFESVMMIPVYKATIEENAPI--------GTTVAKVFAND-TDFIGNG 1210
+K + L +E V+ + NA I G + ++VF D +
Sbjct: 294 YKESLRENL-EVGYE-VLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRT 351
Query: 1211 NGLI------LYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYEL 1264
G + Y L + Q S+TA + ++V D D + P F + Y +
Sbjct: 352 RGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDND-----NAPQFSEKRYVV 406
Query: 1265 EIEENV--NAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPD 1322
++ E+V APV V+ + + N + Y I++ N R F +D + G L +V D
Sbjct: 407 QVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGN---ARGQFYLDAQTGALDVVSPLD 463
Query: 1323 REVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTN 1382
E Y + VRA Q R P++ + G+ V V++ D+NDN+P F
Sbjct: 464 YETTKEYTLRVRA--QDGGRP------PLSN--VSGL------VTVQVLDINDNAPIFV- 506
Query: 1383 GNRPLVTAIPTTAPFGYQVMQLK 1405
+ P + + P GY V+ ++
Sbjct: 507 -STPFQATVLESVPLGYLVLHVQ 528
Score = 60.9 bits (141), Expect = 3e-08
Identities = 48/175 (27%), Positives = 88/175 (50%), Gaps = 14/175 (8%)
Query: 218 IHAIDQDLGVGATLRYELISGND---RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
+ A D D A + Y L+ G+ ++F +D +G + +D + + ++ L
Sbjct: 311 VRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDRE-----EVESYQL 365
Query: 275 QVQAS-QLNNP-LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V+AS Q +P ++ A V + + D NDN P+F Y + + E++ G VL+V A+D
Sbjct: 366 TVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASD 425
Query: 333 KDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+D+G N Y + + +G F +D ++G L V + LD E ++V A++
Sbjct: 426 RDKGSNAVVHYSIMSGNARGQFYLDAQTGALDV--VSPLDYETTKEYTLRVRAQD 478
Score = 51.6 bits (118), Expect = 2e-05
Identities = 42/132 (31%), Positives = 71/132 (53%), Gaps = 14/132 (10%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G A + Y+++ GN ++F LD +G L +DLD E + +VL +Q
Sbjct: 943 VTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGE--LTALVDLDYEDRPE---YVLVIQ 997
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLP---EFEVDF--YNISIVENLPNGFSVLQVMATD 332
A+ + PL ++A V + LLD NDN P FE+ F Y + + P G ++ +V A D
Sbjct: 998 AT--SAPL-VSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGG-AIGRVPAHD 1053
Query: 333 KDQGENGEFTYQ 344
D ++ ++++
Sbjct: 1054 PDISDSLTYSFE 1065
Score = 48.4 bits (110), Expect = 2e-04
Identities = 30/87 (34%), Positives = 46/87 (52%), Gaps = 7/87 (8%)
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD---DPKG--AFSIDPRS 358
P+F+ Y ++ EN P G V + A D D+GE G Y +D D + FS+DP +
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 359 GWLTVRNQTVLDREAHSSLRMKVYAKE 385
G +T + LDRE S+ +V A++
Sbjct: 239 GAVTTAEE--LDRETKSTHVFRVTAQD 263
Score = 39.5 bits (88), Expect = 0.091
Identities = 29/91 (31%), Positives = 49/91 (53%), Gaps = 10/91 (10%)
Query: 439 LMSFVNVEVTLLDANDNNPVF----VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGM 494
L+S V V LLD NDN PV + N Y + +S++ G IG+V A DPD+ +
Sbjct: 1003 LVSRATVHVRLLDRNDNPPVLGNFEILFNNY-VTNRSSSFPGGAIGRVPAHDPDISDS-- 1059
Query: 495 VLYDLQRTSNLTITSPFKINPNTGTVSVAES 525
+ Y +R + L++ +N +TG + ++ +
Sbjct: 1060 LTYSFERGNELSLV---LLNASTGELKLSRA 1087
Score = 36.7 bits (81), Expect = 0.64
Identities = 25/60 (41%), Positives = 35/60 (58%), Gaps = 4/60 (6%)
Query: 144 IRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMA 203
+ A DRDK + N+ VHYSI+SGN G F L+ + L + LDY+ KE+ L + A
Sbjct: 421 VTASDRDKGS--NAVVHYSIMSGNARGQFYLD-AQTGALDVVSPLDYET-TKEYTLRVRA 476
>AB065955-1|BAC06168.1| 2923|Homo sapiens seven transmembrane helix
receptor protein.
Length = 2923
Score = 134 bits (324), Expect = 2e-30
Identities = 137/469 (29%), Positives = 213/469 (45%), Gaps = 41/469 (8%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L + +V VT+LD NDNNP F Y + +A VGT + V AVD D + ++ Y
Sbjct: 590 LTASASVSVTVLDVNDNNPTFTQPE-YTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQ 646
Query: 499 LQRTSNLTITSPFKINPNTG--TVSVAESPI---LEGRHALFVEASDQPANPSERRYSLA 553
+ TS T + F I +G VS+A P+ LE ++ L V ASD R A
Sbjct: 647 I--TSGNT-RNRFSITSQSGGGLVSLA-LPLDYKLERQYVLAVTASDGT------RQDTA 696
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHG 613
+ + VT P F + Y V + GT+V I D E + + +
Sbjct: 697 QIVVNVTDANTHR----PVFQSSHYTVNVNEDRPAGTTVVLISATD--EDTGENARITYF 750
Query: 614 YEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA--NLSIVTNATVHVVDVN 670
E+ +P F ++ +G +T +L ++ Y A+ ++N S T + V DVN
Sbjct: 751 MEDSIPQFRIDADTGAVTTQAELDYEDQVSYTL-AITARDNGIPQKSDTTYLEILVNDVN 809
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
D L+ ++ ++ ++ ++ QI T+ S G V + D D
Sbjct: 810 DNAPQFLRDSYQGSVY--EDVPPFTSVLQISATDRDS---GLNGRVFYTFQGGDDGDGDF 864
Query: 731 AI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
+ + G + T + LDRE Y + A +KG+ +VT+ + D NDNPPVFE
Sbjct: 865 IVESTSGIVRTLRRLDRENVAQYVLRAYA-VDKGMPPARTPMEVTVTVLDVNDNPPVFEQ 923
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTGVVKF 848
++ F+ ENS IG + + ATD DEGTNA MY + G E+F +D +G +
Sbjct: 924 DEFDVFVEENSPIGLAVAR---VTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTA 980
Query: 849 IGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIE 897
+ D LD E + Y L ++ + L S A + + + D NDN P E
Sbjct: 981 LVD-LDYEDRPEYVL-VIQATSAPLVSRATVHVRLLDRNDNPPVLGNFE 1027
Score = 128 bits (310), Expect = 1e-28
Identities = 128/477 (26%), Positives = 208/477 (43%), Gaps = 32/477 (6%)
Query: 457 PVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPN 516
P F P + Y+ ++ N GT + ++A+DPD G+ G + Y + + F ++P
Sbjct: 179 PQFQPPS-YQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPV 237
Query: 517 TGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIPDFM 574
TG V+ AE E + H V A D + RR +LA +TI V T N D P F
Sbjct: 238 TGAVTTAEELDRETKSTHVFRVTAQD---HGMPRRSALATLTILV---TDTNDHD-PVFE 290
Query: 575 GAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVP---FAVEERSGVI 629
Y+ + N+ +G V +R DA ++ Y LL G G P F ++ RSGVI
Sbjct: 291 QQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEG-SGGSPSEVFEIDPRSGVI 349
Query: 630 TVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVK 689
+ R Y A + + + + V D+ + + + V+
Sbjct: 350 RTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVR 409
Query: 690 ENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKR 749
E+ A + S V + I + A+ G + PLD E
Sbjct: 410 EDVTPGA--PVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETT 467
Query: 750 DVYRMTVIA-EFNKGVISG-AGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIK 807
Y + V A + + +S +G+ VT+ + D NDN P+F ++ ++E+ +G +
Sbjct: 468 KEYTLRVRAQDGGRPPLSNVSGL--VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVL 525
Query: 808 MDNIIKATDADEGTNALFMYTLFGEGKEM-FDVDENTGVVKFIGDSLDREKKIMYKLSLV 866
++A DAD G NA Y L G G + F ++ TG + + LDRE+ Y +
Sbjct: 526 H---VQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWIS-VAAELDREEVDFYSFGVE 581
Query: 867 ARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
ARD G L++ A + + + D NDN P F Q E VR++ + + GT+ T+ V
Sbjct: 582 ARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYT--VRLNEDAAV-GTSVVTVSAV 635
Score = 124 bits (299), Expect = 2e-27
Identities = 125/471 (26%), Positives = 198/471 (42%), Gaps = 38/471 (8%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V +LD NDN P+FV S ++ ++ + +G ++ V+A+D D G N + Y R +
Sbjct: 491 VTVQVLDINDNAPIFV-STPFQATVLESVPLGYLVLHVQAIDADAGDNARLEY---RLAG 546
Query: 505 LTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
+ PF IN TG +SVA E ++ VEA D S++V ++V
Sbjct: 547 VGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDN 606
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAV 622
P F Y + + +GTSV + D + ++Y + G F++
Sbjct: 607 N-------PTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRN-RFSI 658
Query: 623 EERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHS 682
+SG V L + + + V+V D N R V + +H
Sbjct: 659 TSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPV-FQSSHY 717
Query: 683 PIIFHVKENSAGAAIGQIFHTNMSSIYGNGTG-NVRFLIANQQDVTDDIAIAEDGTIFTQ 741
+ + ++ AG + I T+ TG N R + + A+ G + TQ
Sbjct: 718 TVNVN-EDRPAGTTVVLISATD------EDTGENARITYFMEDSIPQFRIDADTGAVTTQ 770
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
LD E + Y + + A N G+ + + I + D NDN P F +Y+G + E+
Sbjct: 771 AELDYEDQVSYTLAITARDN-GIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVP 829
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFG--EGKEMFDVDENTGVVKFIGDSLDREKKI 859
T + I ATD D G N YT G +G F V+ +G+V+ + LDRE
Sbjct: 830 PFTSVLQ---ISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTL-RRLDRENVA 885
Query: 860 MYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ------IEENSKV 902
Y L A D G + E+ + + D NDN P F Q +EENS +
Sbjct: 886 QYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPI 936
Score = 117 bits (282), Expect = 3e-25
Identities = 178/731 (24%), Positives = 298/731 (40%), Gaps = 104/731 (14%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V +++ D NDN P F Y ++ + G + +V A D D G N +V Y + +
Sbjct: 385 VFLSVEDDNDNAPQFSEKR-YVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGN- 442
Query: 505 LTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLAVVTIEVTR 561
F ++ TG + V SP+ + L V A D P L VT++V
Sbjct: 443 --ARGQFYLDAQTGALDVV-SPLDYETTKEYTLRVRAQDGGRPPLSNVSGL--VTVQVL- 496
Query: 562 GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDL-LHGYEEGVPF 620
+ P F+ P++ V +V +G V ++ DA ++ + L G PF
Sbjct: 497 ---DINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPF 553
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDERGVLLKG 679
+ +G I+V +L R Y F A L+ + +V V+DVND +
Sbjct: 554 TINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQP 613
Query: 680 AHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIA--NQQDVTDDIAIAEDGT 737
++ V+ N AA+G T +S++ + + + I N ++ + + G
Sbjct: 614 EYT-----VRLNE-DAAVGTSVVT-VSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGL 666
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
+ PLD + Y + V A + G Q+ + + D N + PVF+ + Y +
Sbjct: 667 VSLALPLDYKLERQYVLAVTA--SDGTRQDTA--QIVVNVTDANTHRPVFQSSHYTVNVN 722
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREK 857
E+ GT + + I ATD D G EN + F+ DS+ + +
Sbjct: 723 EDRPAGTTVVL---ISATDEDTG--------------------ENARITYFMEDSIPQFR 759
Query: 858 KIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFT 917
+ DTG ++++AEL D D Q+ + R+ + + T
Sbjct: 760 --------IDADTGAVTTQAEL-----DYED------QVSYTLAITA-RDNGIPQKSDTT 799
Query: 918 IIEVKPKNKFALDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEF 970
+E+ DV+ P FL + E++P T++++++A D DSGLNG++ Y F
Sbjct: 800 YLEI-----LVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTF 854
Query: 971 NSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LN 1026
D F++ G V R L E+ ++ L A+D G
Sbjct: 855 QGG-----DDGDGD-------FIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPAR 902
Query: 1027 DNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQP 1086
+ V V V DVND+ PVF++ ++ VEE + +V ATD D G NA + Y I
Sbjct: 903 TPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVE 962
Query: 1087 SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+ F++ +G L+ +LD E +Y+L + A D ND
Sbjct: 963 GNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQA----TSAPLVSRATVHVRLLDRND 1018
Query: 1147 NSPKFYAFDEL 1157
N P F+ L
Sbjct: 1019 NPPVLGNFEIL 1029
Score = 106 bits (254), Expect = 7e-22
Identities = 116/432 (26%), Positives = 188/432 (43%), Gaps = 59/432 (13%)
Query: 929 LDVDQLGPLFLIPE-------NIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LDV+ P F PE + +GT+++ ++A+D D+ + I Y+ S
Sbjct: 601 LDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQITSG-------- 650
Query: 982 SADALEVKRYFVINERHGHVIVARSLPP----ESEFRLNISALDGGNLNDNISVRVFVKD 1037
+ F I + G +V+ +LP E ++ L ++A DG D + V V D
Sbjct: 651 -----NTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTR-QDTAQIVVNVTD 704
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISP 1097
N H PVF+ + Y NV E + + + ATD D G+NA +TYF++ D+ F I
Sbjct: 705 ANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFME--DSIPQFRIDA 762
Query: 1098 LTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDEL 1157
TG ++ ELD E + Y L + ARDNG DVNDN+P+F D
Sbjct: 763 DTGAVTTQAELDYEDQVSYTLAITARDNG-IPQKSDTTYLEILVNDVNDNAPQFLR-DSY 820
Query: 1158 LEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYS 1217
+ + F SV+ I N + T D DFI I+ +
Sbjct: 821 QGSVYEDVPP-----FTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRT 875
Query: 1218 LPQRKNQQNL------------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELE 1265
L +R +++N+ G+P + + VTV DV D + PVF +++
Sbjct: 876 L-RRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVND-----NPPVFEQDEFDVF 929
Query: 1266 IEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDR 1323
+EEN + + + T+ E N ++ Y I+ N I F +D +G L + D
Sbjct: 930 VEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGN---IPEVFQLDIFSGELTALVDLDY 986
Query: 1324 EVKDTYEVIVRA 1335
E + Y ++++A
Sbjct: 987 EDRPEYVLVIQA 998
Score = 99.5 bits (237), Expect = 8e-20
Identities = 126/488 (25%), Positives = 203/488 (41%), Gaps = 59/488 (12%)
Query: 906 RETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQ 965
R+ T + V+ N A + + + E++ G ++++ A D D G N
Sbjct: 374 RDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAV 433
Query: 966 IRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGG 1023
+ Y S +S +A + F ++ + G + V L E+ E+ L + A DGG
Sbjct: 434 VHY----------SIMSGNA---RGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGG 480
Query: 1024 NLN-DNIS--VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANL 1080
N+S V V V D+ND+ P+F T + V E+ ++ V A DAD G NA L
Sbjct: 481 RPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARL 540
Query: 1081 TYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXX 1140
Y + D PF I+ TG +SV ELDRE D Y V ARD+G
Sbjct: 541 EYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHG-TPALTASASVSVT 599
Query: 1141 XXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVF 1200
DVNDN+P F PE N + +V V + ++ +A T
Sbjct: 600 VLDVNDNNPTF---------TQPEYTVRLNED-AAVGTSVVTVSAVDRDAHSVITYQITS 649
Query: 1201 ANDTDFIG----NGNGLILYSLP-QRKNQQNLGLPSLSSTAILMVTVADVPDEVEM-SDK 1254
N + +G GL+ +LP K ++ L +S T V + + + +
Sbjct: 650 GNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHR 709
Query: 1255 PVFISRYYELEIEENVNAPVELVSLNLTEH--YENFKMRYYILNENDTDIRRTFVIDPRN 1312
PVF S +Y + + E+ A +V ++ T+ EN ++ Y++ D F ID
Sbjct: 710 PVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFM-----EDSIPQFRIDADT 764
Query: 1313 GTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKD 1372
G + D E + +Y + + A +P + T Y + + + D
Sbjct: 765 GAVTTQAELDYEDQVSYTLAITAR----DNGIPQ----------KSDTTY---LEILVND 807
Query: 1373 VNDNSPKF 1380
VNDN+P+F
Sbjct: 808 VNDNAPQF 815
Score = 95.5 bits (227), Expect = 1e-18
Identities = 86/319 (26%), Positives = 145/319 (45%), Gaps = 36/319 (11%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTP--------------TGEKAFI-FLIAPIGPS 127
VTV + D+NDN PIF+ TP+ TV E P G+ A + + +A +G
Sbjct: 491 VTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHD 550
Query: 128 LTIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKV 187
P T+ G DR++ D + V D G AL +S + + V
Sbjct: 551 F--PFTINNGTGWISVAAELDREEV-----DFYSFGVEARDHGTPALTASASVSVTVLDV 603
Query: 188 LDYDAGDKEFQLVI-MASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSL 246
D + + + + + + ++ + A+D+D + + Y++ SGN R FS+
Sbjct: 604 NDNNPTFTQPEYTVRLNEDAAVGTSVV---TVSAVDRD--AHSVITYQITSGNTRNRFSI 658
Query: 247 DSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF 306
S +G + L LD + Q +VL V AS + + A++ + + D N + P F
Sbjct: 659 TSQSGGGLVSLALPLDYKLERQ---YVLAVTAS---DGTRQDTAQIVVNVTDANTHRPVF 712
Query: 307 EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQ 366
+ Y +++ E+ P G +V+ + ATD+D GEN TY ++D F ID +G V Q
Sbjct: 713 QSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTG--AVTTQ 770
Query: 367 TVLDREAHSSLRMKVYAKE 385
LD E S + + A++
Sbjct: 771 AELDYEDQVSYTLAITARD 789
Score = 87.4 bits (207), Expect = 3e-16
Identities = 62/176 (35%), Positives = 85/176 (48%), Gaps = 15/176 (8%)
Query: 218 IHAIDQDLGVGATLRYE---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
+ AID D G L Y L + FSLD V G++ +ELD + + +T V
Sbjct: 203 LRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDRETK-----STHVF 257
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+V A P ++A A + I + D ND+ P FE Y S+ ENL G+ VL V ATD D
Sbjct: 258 RVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGD 317
Query: 335 QGENGEFTYQL-----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N Y+L P F IDPRSG +R + +DRE S ++ V A +
Sbjct: 318 APPNANILYRLLEGSGGSPSEVFEIDPRSG--VIRTRGPVDREEVESYQLTVEASD 371
Score = 86.2 bits (204), Expect = 8e-16
Identities = 115/460 (25%), Positives = 191/460 (41%), Gaps = 56/460 (12%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN P GT + L A+D D G G++ Y ++ + S+ + ++F ++ G
Sbjct: 190 VPENQPAGTPVASLRAIDPDEGEAGRLEYTMDA---LFDSRSN-------QFFSLDPVTG 239
Query: 1000 HVIVARSLPPESEFR--LNISALDGGNLNDNI--SVRVFVKDVNDHFPVFKKTWYNFNVE 1055
V A L E++ ++A D G + ++ + V D NDH PVF++ Y ++
Sbjct: 240 AVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLR 299
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP---FEISPLTGVLSVNGELDRET 1112
E + V ATD D NAN+ Y + P FEI P +GV+ G +DRE
Sbjct: 300 ENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREE 359
Query: 1113 EDKYILTVVARDNGXX-XXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKH---PEADEL 1168
+ Y LTV A D G D NDN+P+F +++ + P A L
Sbjct: 360 VESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVL 419
Query: 1169 --SNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQN 1226
+ + + V+ + + NA G D + + R Q+
Sbjct: 420 RVTASDRDKGSNAVVHYSIMSGNAR-GQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQD 478
Query: 1227 LGLPSLSS-TAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL---- 1281
G P LS+ + ++ V V D+ D + P+F+S ++ + E+V P+ + L++
Sbjct: 479 GGRPPLSNVSGLVTVQVLDIND-----NAPIFVSTPFQATVLESV--PLGYLVLHVQAID 531
Query: 1282 TEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYS 1341
+ +N ++ Y + D F I+ G + + DRE D Y V A
Sbjct: 532 ADAGDNARLEYRLAGVGH-DF--PFTINNGTGWISVAAELDREEVDFYSFGVEAR----- 583
Query: 1342 RELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
+ +T V V + DVNDN+P FT
Sbjct: 584 -----------DHGTPALTA-SASVSVTVLDVNDNNPTFT 611
Score = 86.2 bits (204), Expect = 8e-16
Identities = 66/236 (27%), Positives = 109/236 (46%), Gaps = 13/236 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D+D G A + Y ++SGN R F LD+ G+L + LD + + L+V+
Sbjct: 421 VTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYET-----TKEYTLRVR 475
Query: 278 ASQLNNP-LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A P L V +++LD+NDN P F + +++E++P G+ VL V A D D G
Sbjct: 476 AQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAG 535
Query: 337 ENGEFTYQLD--DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
+N Y+L F+I+ +GW++V + LDRE V A++ P++ +
Sbjct: 536 DNARLEYRLAGVGHDFPFTINNGTGWISVAAE--LDREEVDFYSFGVEARDHGTPALTAS 593
Query: 394 FADSQRIAKWRRQPLETNAPLEKTTYVFPD-KVGTKTENIEYYDEQLMSFVNVEVT 448
+ S + P E T + D VGT + D S + ++T
Sbjct: 594 ASVSVTVLDVNDNNPTFTQP-EYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQIT 648
Score = 79.0 bits (186), Expect = 1e-13
Identities = 57/169 (33%), Positives = 88/169 (52%), Gaps = 12/169 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I A D+D G A + Y + + F +D+ G++ + ELD + + + + L +
Sbjct: 734 ISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQVS-----YTLAIT 786
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P K+ +EI + D+NDN P+F D Y S+ E++P SVLQ+ ATD+D G
Sbjct: 787 ARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGL 846
Query: 338 NGE--FTYQ-LDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
NG +T+Q DD G F ++ SG VR LDRE + ++ YA
Sbjct: 847 NGRVFYTFQGGDDGDGDFIVESTSG--IVRTLRRLDRENVAQYVLRAYA 893
Score = 74.5 bits (175), Expect = 3e-12
Identities = 80/332 (24%), Positives = 137/332 (41%), Gaps = 23/332 (6%)
Query: 44 VDSDSPQNVVKFRLGCDFD-EGDDLVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPY 102
+ S S +V L D+ E ++ + A + V + D N + P+F + Y
Sbjct: 658 ITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHY 717
Query: 103 HVTVDELTPTGEKAFIFLIAP--IGPSLTIPLTVPRGLTIFK---DIRAFDRDKPNTPNS 157
V V+E P G + G + I + + F+ D A
Sbjct: 718 TVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYED 777
Query: 158 DVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEIL-FP 215
V Y++ ++ D+G K ++L D D Q + + +++++ F
Sbjct: 778 QVSYTLAITARDNG-----IPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFT 832
Query: 216 E--PIHAIDQDLGVGATLRYELISGNDRKL-FSLDSVNGSLFLEKELDLDAEHNLQANTF 272
I A D+D G+ + Y G+D F ++S +G + + LD + +
Sbjct: 833 SVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRE-----NVAQY 887
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
VL+ A P V + +LD+NDN P FE D +++ + EN P G +V +V ATD
Sbjct: 888 VLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATD 947
Query: 333 KDQGENGEFTYQLDDPK--GAFSIDPRSGWLT 362
D+G N + YQ+ + F +D SG LT
Sbjct: 948 PDEGTNAQIMYQIVEGNIPEVFQLDIFSGELT 979
Score = 70.1 bits (164), Expect = 6e-11
Identities = 97/383 (25%), Positives = 159/383 (41%), Gaps = 53/383 (13%)
Query: 1043 PVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ---PSDTDLPFEISPLT 1099
P F+ Y V E Q + + A D D G+ L Y + S ++ F + P+T
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 1100 GVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLE 1159
G ++ ELDRET+ ++ V A+D+G D ND+ P F E E
Sbjct: 239 GAVTTAEELDRETKSTHVFRVTAQDHG-MPRRSALATLTILVTDTNDHDPVF----EQQE 293
Query: 1160 WKHPEADELSNHNFESVMMIPVYKATIEENAPI--------GTTVAKVFAND-TDFIGNG 1210
+K + L +E V+ + NA I G + ++VF D +
Sbjct: 294 YKESLRENL-EVGYE-VLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRT 351
Query: 1211 NGLI------LYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYEL 1264
G + Y L + Q S+TA + ++V D D + P F + Y +
Sbjct: 352 RGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDND-----NAPQFSEKRYVV 406
Query: 1265 EIEENV--NAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPD 1322
++ E+V APV V+ + + N + Y I++ N R F +D + G L +V D
Sbjct: 407 QVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGN---ARGQFYLDAQTGALDVVSPLD 463
Query: 1323 REVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTN 1382
E Y + VRA Q R P++ + G+ V V++ D+NDN+P F
Sbjct: 464 YETTKEYTLRVRA--QDGGRP------PLSN--VSGL------VTVQVLDINDNAPIFV- 506
Query: 1383 GNRPLVTAIPTTAPFGYQVMQLK 1405
+ P + + P GY V+ ++
Sbjct: 507 -STPFQATVLESVPLGYLVLHVQ 528
Score = 60.9 bits (141), Expect = 3e-08
Identities = 48/175 (27%), Positives = 88/175 (50%), Gaps = 14/175 (8%)
Query: 218 IHAIDQDLGVGATLRYELISGND---RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
+ A D D A + Y L+ G+ ++F +D +G + +D + + ++ L
Sbjct: 311 VRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDRE-----EVESYQL 365
Query: 275 QVQAS-QLNNP-LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V+AS Q +P ++ A V + + D NDN P+F Y + + E++ G VL+V A+D
Sbjct: 366 TVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASD 425
Query: 333 KDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+D+G N Y + + +G F +D ++G L V + LD E ++V A++
Sbjct: 426 RDKGSNAVVHYSIMSGNARGQFYLDAQTGALDV--VSPLDYETTKEYTLRVRAQD 478
Score = 51.6 bits (118), Expect = 2e-05
Identities = 42/132 (31%), Positives = 71/132 (53%), Gaps = 14/132 (10%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G A + Y+++ GN ++F LD +G L +DLD E + +VL +Q
Sbjct: 943 VTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGE--LTALVDLDYEDRPE---YVLVIQ 997
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLP---EFEVDF--YNISIVENLPNGFSVLQVMATD 332
A+ + PL ++A V + LLD NDN P FE+ F Y + + P G ++ +V A D
Sbjct: 998 AT--SAPL-VSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGG-AIGRVPAHD 1053
Query: 333 KDQGENGEFTYQ 344
D ++ ++++
Sbjct: 1054 PDISDSLTYSFE 1065
Score = 48.4 bits (110), Expect = 2e-04
Identities = 30/87 (34%), Positives = 46/87 (52%), Gaps = 7/87 (8%)
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD---DPKG--AFSIDPRS 358
P+F+ Y ++ EN P G V + A D D+GE G Y +D D + FS+DP +
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 359 GWLTVRNQTVLDREAHSSLRMKVYAKE 385
G +T + LDRE S+ +V A++
Sbjct: 239 GAVTTAEE--LDRETKSTHVFRVTAQD 263
Score = 39.5 bits (88), Expect = 0.091
Identities = 29/91 (31%), Positives = 49/91 (53%), Gaps = 10/91 (10%)
Query: 439 LMSFVNVEVTLLDANDNNPVF----VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGM 494
L+S V V LLD NDN PV + N Y + +S++ G IG+V A DPD+ +
Sbjct: 1003 LVSRATVHVRLLDRNDNPPVLGNFEILFNNY-VTNRSSSFPGGAIGRVPAHDPDISDS-- 1059
Query: 495 VLYDLQRTSNLTITSPFKINPNTGTVSVAES 525
+ Y +R + L++ +N +TG + ++ +
Sbjct: 1060 LTYSFERGNELSLV---LLNASTGELKLSRA 1087
Score = 36.7 bits (81), Expect = 0.64
Identities = 25/60 (41%), Positives = 35/60 (58%), Gaps = 4/60 (6%)
Query: 144 IRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMA 203
+ A DRDK + N+ VHYSI+SGN G F L+ + L + LDY+ KE+ L + A
Sbjct: 421 VTASDRDKGS--NAVVHYSIMSGNARGQFYLD-AQTGALDVVSPLDYET-TKEYTLRVRA 476
>AF217288-1|AAK82656.1| 1310|Homo sapiens protocadherin-S protein.
Length = 1310
Score = 133 bits (322), Expect = 4e-30
Identities = 139/517 (26%), Positives = 221/517 (42%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D N N+PVF + E S+ NA
Sbjct: 211 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DPNANHPVFKEPEI-EVSIPENAP 263
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 264 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 324 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + +++ + + ++
Sbjct: 378 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ I T +S++
Sbjct: 436 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG----IQLTKVSAM 491
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ N + D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 550
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y ++ EN + GT +I TD D G N+
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 606
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 607 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701
Score = 112 bits (269), Expect = 1e-23
Identities = 114/473 (24%), Positives = 202/473 (42%), Gaps = 23/473 (4%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+++ V + + D NDN P+F P+ + S+ N+ + + AVDPD+G NG+
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLF-PATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 497 YDLQRTSNLTITSPFKINPNTGTVS--VAESPILEGRHALFVEASDQPANPSERRYSLAV 554
Y+L ++ N+ + P + + + + +V +R S A+
Sbjct: 176 YELIKSQNIFGLDVIE-TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 234
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQN---DVSYDL 610
+ + VT + P F E + N +GTSV Q+ DA +N S+
Sbjct: 235 LQVSVTDPNANH----PVFKEPEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN 290
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L F + +G+IT+ + L R P + +A + + V+V DVN
Sbjct: 291 LVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDGGLMPARAMVLVNVTDVN 349
Query: 671 DE-RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D + ++ +P+ V + +I ++ + G V ++
Sbjct: 350 DNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVI-AEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ + T LD E Y + ++ A+ K ++ + + + I ++DENDN PVF
Sbjct: 410 PVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKDENDNAPVFT 467
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ I EN+ G ++ + A DAD G NA Y L + F +D TG++
Sbjct: 468 QSFVTVSIPENNSPGIQLTK---VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTV 524
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
+ LDREK+ Y +++A+D G L+S + + I D+NDN P F E N
Sbjct: 525 V-KKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Score = 97.9 bits (233), Expect = 2e-19
Identities = 81/246 (32%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G + K++A+D DSG N +I Y
Sbjct: 446 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYL 504
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 505 LGPDA--PPE------------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF YNF V E +G + TD D+G N+ +T I
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 610
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 611 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 667
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 668 DNKPVF 673
Score = 90.2 bits (214), Expect = 5e-17
Identities = 124/488 (25%), Positives = 197/488 (40%), Gaps = 70/488 (14%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P+GT++ +L+A D D G N +I + F++ V S ++ +R F +N G
Sbjct: 258 IPENAPVGTSVTQLHATDADIGENAKIHFSFSNLV----SNIA------RRLFHLNATTG 307
Query: 1000 HVIVARSLPPES--EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTW----YNFN 1053
+ + L E +L + A DGG + V V V DVND+ P + N
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 367
Query: 1054 V--EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGEL 1108
V E + + TD D N +T F +D ++PF + P+ +L L
Sbjct: 368 VVLSENIPLNTKIALITVTDKDADHNGRVTCF---TDHEIPFRLRPVFSNQFLLETAAYL 424
Query: 1109 DRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADEL 1168
D E+ +Y + ++A D G D NDN+P F + PE +
Sbjct: 425 DYESTKEYAIKLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPENNSP 481
Query: 1169 SNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL- 1227
+ M + N +G F+ D G ++ L + K + L
Sbjct: 482 GIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLD---CRTGMLTVVKKLDREKEDKYLF 538
Query: 1228 -------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVS 1278
G+P L+S + V++ D D + PVF Y + EN+ + V L++
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQND-----NSPVFTHNEYNFYVPENLPRHGTVGLIT 593
Query: 1279 LNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
+ ++ +N + IL+END F ID + G + S DRE +++Y V+
Sbjct: 594 VTDPDYGDNSAVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK---- 644
Query: 1339 KYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAP 1396
AED KV + + DVNDN P F N +P+T P
Sbjct: 645 -------------AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP 691
Query: 1397 FGYQVMQL 1404
G V Q+
Sbjct: 692 -GTVVFQV 698
Score = 77.4 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 488 VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE-----DKYLFTIL 541
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + YN + ENLP +V + TD D G+
Sbjct: 542 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 601
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 602 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 647
Score = 72.1 bits (169), Expect = 1e-11
Identities = 51/178 (28%), Positives = 90/178 (50%), Gaps = 21/178 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A+D D+G+ YELI + +F LD + L ++KELD + + +T+
Sbjct: 163 AVDPDVGINGVQNYELIKSQN--IFGLDVIETPEGDKMPQLIVQKELDRE-----EKDTY 215
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V++V+ P +++ A +++ + D N N P F+ +SI EN P G SV Q+ ATD
Sbjct: 216 VMKVKVEDGGFPQRSSTAILQVSVTDPNANHPVFKEPEIEVSIPENAPVGTSVTQLHATD 275
Query: 333 KDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D GEN + + + + F ++ +G +T++ LDRE + ++ V A +
Sbjct: 276 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP--LDREETPNHKLLVLASD 331
Score = 66.9 bits (156), Expect = 5e-10
Identities = 82/341 (24%), Positives = 143/341 (41%), Gaps = 47/341 (13%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTV 134
++I + + IED+NDN P+F T ++++ E + K L A + P + I
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK--YTLPAAVDPDVGI--NG 172
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR-KVLDYDAG 193
+ + K F D TP D ++ + L+ K +++ KV D
Sbjct: 173 VQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE-----LDREEKDTYVMKVKVEDGGFP 227
Query: 194 DKEFQLVIMASG----------KRIHKEILFPE---------PIHAIDQDLGVGATLRYE 234
+ ++ S K E+ PE +HA D D+G A + +
Sbjct: 228 QRSSTAILQVSVTDPNANHPVFKEPEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFS 287
Query: 235 ---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQAR 291
L+S R+LF L++ G + +++ LD + N + L V AS + L A+A
Sbjct: 288 FSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----LLVLAS--DGGLMPARAM 340
Query: 292 VEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN+P ++ + N ++V EN+P + + TDKD NG T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-F 399
Query: 346 DDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D + F + P S + LD E+ +K+ A +
Sbjct: 400 TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAAD 440
Score = 66.9 bits (156), Expect = 5e-10
Identities = 58/217 (26%), Positives = 94/217 (43%), Gaps = 18/217 (8%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN I + A+D D G+NG YE I D +E ++
Sbjct: 148 IPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNI----FGLDVIETPE----GDKMP 199
Query: 1000 HVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+IV + L E + + + + DGG + ++V V D N + PVFK+ ++
Sbjct: 200 QLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDPNANHPVFKEPEIEVSIP 259
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP---FEISPLTGVLSVNGELDRET 1112
E + ++ ATDAD G+NA + + +++ F ++ TG++++ LDRE
Sbjct: 260 ENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREE 319
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
+ L V+A D G DVNDN P
Sbjct: 320 TPNHKLLVLASDGG---LMPARAMVLVNVTDVNDNVP 353
Score = 64.1 bits (149), Expect = 4e-09
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 413 SNQFLLETAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 469
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G + +V A D D G N + Y L D FS+D R+G LTV +
Sbjct: 470 FVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-- 527
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 528 LDREKEDKYLFTILAKD 544
Score = 58.8 bits (136), Expect = 1e-07
Identities = 102/485 (21%), Positives = 184/485 (37%), Gaps = 50/485 (10%)
Query: 940 IPENIPIGTTIIKLN-ALDLDSGLNGQIRYEFNSEVY-IPPSKLSADALEVKRYFVINER 997
+PEN+ IG + LN +L + L ++++ + +P ++ D E+ F R
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEI---FTTGAR 90
Query: 998 HGHVIVARSLPPESEFRLNIS-ALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ +P + + A+ + + +R ++D+ND+ P+F T N ++ E
Sbjct: 91 IDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPE 150
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGELDRE 1111
A D D G N Y + S ++ L V ELDRE
Sbjct: 151 NSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE 210
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
+D Y++ V D G D N N P F + +E PE +
Sbjct: 211 EKDTYVMKVKVEDGG-FPQRSSTAILQVSVTDPNANHPVFK--EPEIEVSIPENAPVGT- 266
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLP----QRKNQ 1224
SV + A I ENA I + + + +N + + N GLI P + N
Sbjct: 267 ---SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 1225 QNLGLPS----LSSTAILMVTVADVPDEVEMSDKPVFISRYYE-LEIEENVNAPVELVSL 1279
+ L L S + + A+++V V DV D V D ++ + + + EN+ ++ +
Sbjct: 324 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 383
Query: 1280 NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQK 1339
+T+ + R +++ R R V ++ A
Sbjct: 384 TVTDKDADHNGRVTCFTDHEIPFRL------------------RPVFSNQFLLETAAYLD 425
Query: 1340 YSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGY 1399
Y + I +A D + + +++KD NDN+P FT + +IP G
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF--VTVSIPENNSPGI 483
Query: 1400 QVMQL 1404
Q+ ++
Sbjct: 484 QLTKV 488
Score = 58.4 bits (135), Expect = 2e-07
Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 644
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V N S LP+ G V QV+A D D
Sbjct: 645 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDND 704
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 705 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 750
Score = 52.8 bits (121), Expect = 9e-06
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ PSN YE + S GTV+ +V AVD D G N V Y
Sbjct: 655 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 714 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 768
Query: 556 TIEV 559
+ V
Sbjct: 769 NLFV 772
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/206 (24%), Positives = 93/206 (45%), Gaps = 27/206 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSLTI 130
G+ +++ ++V V I D NDN P+F Y+ V E P G I + P G + +
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 605
Query: 131 PL---------TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L T+ + + +FDR+K + + V D G + SS K
Sbjct: 606 TLSILDENDDFTIDSQTGVIRPNISFDREKQES-----YTFYVKAEDGGRVSRSSSAKVT 660
Query: 182 LLLRKVLD------YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
+ + V D + ++LV+ ++ ++F + A+D D G+ A +RY +
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT---VVFQ--VIAVDNDTGMNAEVRYSI 715
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDL 261
+ GN R LF++D G++ L ++ D+
Sbjct: 716 VGGNTRDLFAIDQETGNITLMEKCDV 741
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/114 (29%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS--LTIPLTVPRGLT 139
S T Y++ D + + VT++ + K +F++ P S L +P T P G
Sbjct: 638 SYTFYVK-AEDGGRVSRSSSAKVTINVVDVNDNKP-VFIVPPSNCSYELVLPSTNP-GTV 694
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 695 VFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 745
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
LT A D+D G NA I Y + + P F++D +G + VV L R+
Sbjct: 485 LTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
>AF206516-1|AAK82655.1| 1347|Homo sapiens protocadherin-S protein.
Length = 1347
Score = 133 bits (322), Expect = 4e-30
Identities = 139/517 (26%), Positives = 221/517 (42%), Gaps = 36/517 (6%)
Query: 415 EKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
EK TYV KV E+ + + + V VT D N N+PVF + E S+ NA
Sbjct: 211 EKDTYVMKVKV----EDGGFPQRSSTAILQVSVT--DPNANHPVFKEPEI-EVSIPENAP 263
Query: 475 VGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRH 532
VGT + ++ A D D+G+N + + + F +N TG +++ E E H
Sbjct: 264 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 533 ALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIP-DFMGAPYEFWV--GSNVGIG 589
L V ASD P+ A+V + VT N P I ++ P V N+ +
Sbjct: 324 KLLVLASDGGLMPAR-----AMVLVNVT-DVNDNVPSIDIRYIVNPVNDTVVLSENIPLN 377
Query: 590 TSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN-RPMYDFEAV 648
T + I V D ++ +E +PF + +++ + + ++
Sbjct: 378 TKIALITVTDKDADHNGRVTCFTDHE--IPFRLRPVFSNQFLLETAAYLDYESTKEYAIK 435
Query: 649 ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSI 708
L +A + + + + V DE S + + EN++ I T +S++
Sbjct: 436 LLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPG----IQLTKVSAM 491
Query: 709 YGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ N + D + ++ G + K LDREK D Y T++A+ N GV
Sbjct: 492 DADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDN-GVPPL 550
Query: 768 AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN-SKIGTEIKMDNIIKATDADEGTNALFM 826
V + I D+NDN PVF H Y ++ EN + GT +I TD D G N+
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV----GLITVTDPDYGDNSAVT 606
Query: 827 YTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIG 884
++ E + F +D TGV++ S DREK+ Y + A D G + SS A++ I +
Sbjct: 607 LSILDENDD-FTIDSQTGVIR-PNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
D NDNKP F N + + GT F +I V
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAV 701
Score = 112 bits (269), Expect = 1e-23
Identities = 114/473 (24%), Positives = 202/473 (42%), Gaps = 23/473 (4%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+++ V + + D NDN P+F P+ + S+ N+ + + AVDPD+G NG+
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLF-PATVINISIPENSAINSKYTLPAAVDPDVGINGVQN 175
Query: 497 YDLQRTSNLTITSPFKINPNTGTVS--VAESPILEGRHALFVEASDQPANPSERRYSLAV 554
Y+L ++ N+ + P + + + + +V +R S A+
Sbjct: 176 YELIKSQNIFGLDVIE-TPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAI 234
Query: 555 VTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQN---DVSYDL 610
+ + VT + P F E + N +GTSV Q+ DA +N S+
Sbjct: 235 LQVSVTDPNANH----PVFKEPEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSN 290
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L F + +G+IT+ + L R P + +A + + V+V DVN
Sbjct: 291 LVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA-SDGGLMPARAMVLVNVTDVN 349
Query: 671 DE-RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D + ++ +P+ V + +I ++ + G V ++
Sbjct: 350 DNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLR 409
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVI-AEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ + T LD E Y + ++ A+ K ++ + + + I ++DENDN PVF
Sbjct: 410 PVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAM--LFIKVKDENDNAPVFT 467
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ I EN+ G ++ + A DAD G NA Y L + F +D TG++
Sbjct: 468 QSFVTVSIPENNSPGIQLTK---VSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTV 524
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
+ LDREK+ Y +++A+D G L+S + + I D+NDN P F E N
Sbjct: 525 V-KKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYN 576
Score = 97.9 bits (233), Expect = 2e-19
Identities = 81/246 (32%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN +A I+VK +N A Q IPEN G + K++A+D DSG N +I Y
Sbjct: 446 LNQSA-MLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYL 504
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NL 1025
+ PP F ++ R G + V + L E E + I A D G L
Sbjct: 505 LGPDA--PPE------------FSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPL 550
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
N++V V + D ND+ PVF YNF V E +G + TD D+G N+ +T I
Sbjct: 551 TSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL 610
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ D F I TGV+ N DRE ++ Y V A D G DVN
Sbjct: 611 DENDD--FTIDSQTGVIRPNISFDREKQESYTFYVKAEDGG-RVSRSSSAKVTINVVDVN 667
Query: 1146 DNSPKF 1151
DN P F
Sbjct: 668 DNKPVF 673
Score = 90.2 bits (214), Expect = 5e-17
Identities = 124/488 (25%), Positives = 197/488 (40%), Gaps = 70/488 (14%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P+GT++ +L+A D D G N +I + F++ V S ++ +R F +N G
Sbjct: 258 IPENAPVGTSVTQLHATDADIGENAKIHFSFSNLV----SNIA------RRLFHLNATTG 307
Query: 1000 HVIVARSLPPES--EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTW----YNFN 1053
+ + L E +L + A DGG + V V V DVND+ P + N
Sbjct: 308 LITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDT 367
Query: 1054 V--EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGEL 1108
V E + + TD D N +T F +D ++PF + P+ +L L
Sbjct: 368 VVLSENIPLNTKIALITVTDKDADHNGRVTCF---TDHEIPFRLRPVFSNQFLLETAAYL 424
Query: 1109 DRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADEL 1168
D E+ +Y + ++A D G D NDN+P F + PE +
Sbjct: 425 DYESTKEYAIKLLAADAG-KPPLNQSAMLFIKVKDENDNAPVF--TQSFVTVSIPENNSP 481
Query: 1169 SNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL- 1227
+ M + N +G F+ D G ++ L + K + L
Sbjct: 482 GIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLD---CRTGMLTVVKKLDREKEDKYLF 538
Query: 1228 -------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAPVELVS 1278
G+P L+S + V++ D D + PVF Y + EN+ + V L++
Sbjct: 539 TILAKDNGVPPLTSNVTVFVSIIDQND-----NSPVFTHNEYNFYVPENLPRHGTVGLIT 593
Query: 1279 LNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
+ ++ +N + IL+END F ID + G + S DRE +++Y V+
Sbjct: 594 VTDPDYGDNSAVTLSILDEND-----DFTIDSQTGVIRPNISFDREKQESYTFYVK---- 644
Query: 1339 KYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAIPTTAP 1396
AED KV + + DVNDN P F N +P+T P
Sbjct: 645 -------------AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNP 691
Query: 1397 FGYQVMQL 1404
G V Q+
Sbjct: 692 -GTVVFQV 698
Score = 77.4 bits (182), Expect = 4e-13
Identities = 52/168 (30%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A + Y L+ + FSLD G L + K+LD + E + ++ +
Sbjct: 488 VSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKE-----DKYLFTIL 541
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P T+ V + ++D NDN P F + YN + ENLP +V + TD D G+
Sbjct: 542 AKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGD 601
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N T + D F+ID ++G +R DRE S V A++
Sbjct: 602 NSAVTLSILDENDDFTIDSQTG--VIRPNISFDREKQESYTFYVKAED 647
Score = 72.1 bits (169), Expect = 1e-11
Identities = 51/178 (28%), Positives = 90/178 (50%), Gaps = 21/178 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A+D D+G+ YELI + +F LD + L ++KELD + + +T+
Sbjct: 163 AVDPDVGINGVQNYELIKSQN--IFGLDVIETPEGDKMPQLIVQKELDRE-----EKDTY 215
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V++V+ P +++ A +++ + D N N P F+ +SI EN P G SV Q+ ATD
Sbjct: 216 VMKVKVEDGGFPQRSSTAILQVSVTDPNANHPVFKEPEIEVSIPENAPVGTSVTQLHATD 275
Query: 333 KDQGENGEFTYQLDD-----PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D GEN + + + + F ++ +G +T++ LDRE + ++ V A +
Sbjct: 276 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEP--LDREETPNHKLLVLASD 331
Score = 66.9 bits (156), Expect = 5e-10
Identities = 82/341 (24%), Positives = 143/341 (41%), Gaps = 47/341 (13%)
Query: 75 NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTV 134
++I + + IED+NDN P+F T ++++ E + K L A + P + I
Sbjct: 117 DEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK--YTLPAAVDPDVGI--NG 172
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR-KVLDYDAG 193
+ + K F D TP D ++ + L+ K +++ KV D
Sbjct: 173 VQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKE-----LDREEKDTYVMKVKVEDGGFP 227
Query: 194 DKEFQLVIMASG----------KRIHKEILFPE---------PIHAIDQDLGVGATLRYE 234
+ ++ S K E+ PE +HA D D+G A + +
Sbjct: 228 QRSSTAILQVSVTDPNANHPVFKEPEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFS 287
Query: 235 ---LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQAR 291
L+S R+LF L++ G + +++ LD + N + L V AS + L A+A
Sbjct: 288 FSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK-----LLVLAS--DGGLMPARAM 340
Query: 292 VEIELLDLNDNLPEFEVDFY----NISIV--ENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN+P ++ + N ++V EN+P + + TDKD NG T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC-F 399
Query: 346 DDPKGAFSIDP-RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D + F + P S + LD E+ +K+ A +
Sbjct: 400 TDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAAD 440
Score = 66.9 bits (156), Expect = 5e-10
Identities = 58/217 (26%), Positives = 94/217 (43%), Gaps = 18/217 (8%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN I + A+D D G+NG YE I D +E ++
Sbjct: 148 IPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNI----FGLDVIETPE----GDKMP 199
Query: 1000 HVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+IV + L E + + + + DGG + ++V V D N + PVFK+ ++
Sbjct: 200 QLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDPNANHPVFKEPEIEVSIP 259
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP---FEISPLTGVLSVNGELDRET 1112
E + ++ ATDAD G+NA + + +++ F ++ TG++++ LDRE
Sbjct: 260 ENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREE 319
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
+ L V+A D G DVNDN P
Sbjct: 320 TPNHKLLVLASDGG---LMPARAMVLVNVTDVNDNVP 353
Score = 64.1 bits (149), Expect = 4e-09
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 6/137 (4%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+ LE LD E + + +++ A+ P A + I++ D NDN P F
Sbjct: 413 SNQFLLETAAYLDYESTKE---YAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQS 469
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTV 368
F +SI EN G + +V A D D G N + Y L D FS+D R+G LTV +
Sbjct: 470 FVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKK-- 527
Query: 369 LDREAHSSLRMKVYAKE 385
LDRE + AK+
Sbjct: 528 LDREKEDKYLFTILAKD 544
Score = 58.8 bits (136), Expect = 1e-07
Identities = 102/485 (21%), Positives = 184/485 (37%), Gaps = 50/485 (10%)
Query: 940 IPENIPIGTTIIKLN-ALDLDSGLNGQIRYEFNSEVY-IPPSKLSADALEVKRYFVINER 997
+PEN+ IG + LN +L + L ++++ + +P ++ D E+ F R
Sbjct: 34 MPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEI---FTTGAR 90
Query: 998 HGHVIVARSLPPESEFRLNIS-ALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ +P + + A+ + + +R ++D+ND+ P+F T N ++ E
Sbjct: 91 IDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPE 150
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGVLSVNGELDRE 1111
A D D G N Y + S ++ L V ELDRE
Sbjct: 151 NSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDRE 210
Query: 1112 TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH 1171
+D Y++ V D G D N N P F + +E PE +
Sbjct: 211 EKDTYVMKVKVEDGG-FPQRSSTAILQVSVTDPNANHPVFK--EPEIEVSIPENAPVGT- 266
Query: 1172 NFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLP----QRKNQ 1224
SV + A I ENA I + + + +N + + N GLI P + N
Sbjct: 267 ---SVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 1225 QNLGLPS----LSSTAILMVTVADVPDEVEMSDKPVFISRYYE-LEIEENVNAPVELVSL 1279
+ L L S + + A+++V V DV D V D ++ + + + EN+ ++ +
Sbjct: 324 KLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALI 383
Query: 1280 NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQK 1339
+T+ + R +++ R R V ++ A
Sbjct: 384 TVTDKDADHNGRVTCFTDHEIPFRL------------------RPVFSNQFLLETAAYLD 425
Query: 1340 YSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGY 1399
Y + I +A D + + +++KD NDN+P FT + +IP G
Sbjct: 426 YESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSF--VTVSIPENNSPGI 483
Query: 1400 QVMQL 1404
Q+ ++
Sbjct: 484 QLTKV 488
Score = 58.4 bits (135), Expect = 2e-07
Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 13/166 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + + ++ ND F++DS G + + D E + ++ V+
Sbjct: 592 ITVTDPDYGDNSAVTLSILDENDD--FTIDSQTG--VIRPNISFDRE---KQESYTFYVK 644
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A +++ A+V I ++D+NDN P F V N S LP+ G V QV+A D D
Sbjct: 645 AEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDND 704
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ-TVLDREAHSSL 377
G N E Y + + + F+ID +G +T+ + V D H L
Sbjct: 705 TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVL 750
Score = 52.8 bits (121), Expect = 9e-06
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFV--PSNL-YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
S V + ++D NDN PVF+ PSN YE + S GTV+ +V AVD D G N V Y
Sbjct: 655 SSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPST-NPGTVVFQVIAVDNDTGMNAEVRY 713
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + + F I+ TG +++ E + G H + V+A+D + +S+ +V
Sbjct: 714 SIVGGNTRDL---FAIDQETGNITLMEKCDVTDLGLHRVLVKAND--LGQPDSLFSVVIV 768
Query: 556 TIEV 559
+ V
Sbjct: 769 NLFV 772
Score = 52.0 bits (119), Expect = 2e-05
Identities = 51/206 (24%), Positives = 93/206 (45%), Gaps = 27/206 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSLTI 130
G+ +++ ++V V I D NDN P+F Y+ V E P G I + P G + +
Sbjct: 546 GVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAV 605
Query: 131 PL---------TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L T+ + + +FDR+K + + V D G + SS K
Sbjct: 606 TLSILDENDDFTIDSQTGVIRPNISFDREKQES-----YTFYVKAEDGGRVSRSSSAKVT 660
Query: 182 LLLRKVLD------YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
+ + V D + ++LV+ ++ ++F + A+D D G+ A +RY +
Sbjct: 661 INVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT---VVFQ--VIAVDNDTGMNAEVRYSI 715
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDL 261
+ GN R LF++D G++ L ++ D+
Sbjct: 716 VGGNTRDLFAIDQETGNITLMEKCDV 741
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/114 (29%), Positives = 53/114 (46%), Gaps = 8/114 (7%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS--LTIPLTVPRGLT 139
S T Y++ D + + VT++ + K +F++ P S L +P T P G
Sbjct: 638 SYTFYVK-AEDGGRVSRSSSAKVTINVVDVNDNKP-VFIVPPSNCSYELVLPSTNP-GTV 694
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
+F+ I A D D N++V YSIV GN FA++ + L+ K D G
Sbjct: 695 VFQVI-AVDND--TGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLG 745
Score = 34.3 bits (75), Expect = 3.4
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
LT A D+D G NA I Y + + P F++D +G + VV L R+
Sbjct: 485 LTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
>AF152515-1|AAD43775.1| 820|Homo sapiens protocadherin gamma A8
short form protein protein.
Length = 820
Score = 128 bits (308), Expect = 2e-28
Identities = 134/477 (28%), Positives = 202/477 (42%), Gaps = 35/477 (7%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
NI E VE+ ++D NDNNP F +L E + A G +AVDPD+G
Sbjct: 105 NINTLVEDKGKLFGVEIEIIDINDNNPKFQVEDL-EVKINEIAVPGARYPLPEAVDPDVG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSE 547
N + Y L + ++ N V E + E H L + ASD P
Sbjct: 164 VNSLQSYQLSPNHHFSLDVQTGDNGAINPELVLERALDREEEAAHHLVLTASDGGKPPRS 223
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QND 605
+ V ++ T N P P + Y V N+ GT + + +D E
Sbjct: 224 STVRIHVTVLD----TNDNAPVFPHPI---YRVKVLENMPPGTRLLTVTASDPDEGINGK 276
Query: 606 VSYDLLHGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
V+Y E+ P F + E +G I++ L Y+ E A A L T +
Sbjct: 277 VAYKFRKINEKQTPLFQLNENTGEISIAKSLDYEECSFYEMEIQAEDVGALLGR-TKLLI 335
Query: 665 HVVDVNDERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
V DVND R V++ SP++ ENS + I ++ G V +
Sbjct: 336 SVEDVNDNRPEVIITSLFSPVL----ENSLPGTV--IAFLSVHDQDSGKNGQVVCYTRDN 389
Query: 724 QDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDN 783
+ +I + T+K LDRE +Y +TV+A + G + Q+ +++ D NDN
Sbjct: 390 LPFKLEKSIGNYYRLVTRKYLDRENVSIYNITVMAS-DLGTPPLSTETQIALHVADINDN 448
Query: 784 PPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMY-----TLFGEGKEMF- 837
PP F HA+Y +I+EN+ G I + A D D NA Y TL G +
Sbjct: 449 PPTFPHASYSAYILENNLRGASIFS---LTAHDPDSQENAQVTYSVTEDTLQGAPLSSYI 505
Query: 838 DVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
++ +TGV+ + S D E+ +L + A D+G LSS L + + D+NDN PE
Sbjct: 506 SINSDTGVL-YALQSFDYEQIRDLQLLVTASDSGDPPLSSNMSLSLFVLDQNDNAPE 561
Score = 80.2 bits (189), Expect = 5e-14
Identities = 109/422 (25%), Positives = 173/422 (40%), Gaps = 57/422 (13%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G++ T +DRE+ + N V ++ V I I D NDN P F+ E
Sbjct: 82 GSLITAGRIDREELCAQSPRCLININTLVEDKGKLFGVEIEIIDINDNNPKFQVEDLEVK 141
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
I E + G + +A D D G N+L Y L F +D T GD+
Sbjct: 142 INEIAVPGARYPLP---EAVDPDVGVNSLQSYQL--SPNHHFSLDVQT------GDNGAI 190
Query: 856 EKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAG 915
+++ + +L + EA +++ + KP +S VRIH
Sbjct: 191 NPELVLERALDREE------EAAHHLVLTASDGGKPP-----RSSTVRIH---------- 229
Query: 916 FTIIEVKPKNK-FALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEV 974
T+++ F + ++ L EN+P GT ++ + A D D G+NG++ Y+F
Sbjct: 230 VTVLDTNDNAPVFPHPIYRVKVL----ENMPPGTRLLTVTASDPDEGINGKVAYKFR--- 282
Query: 975 YIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDNISVR 1032
K++ + F +NE G + +A+SL E S + + I A D G L +
Sbjct: 283 -----KINEKQTPL---FQLNENTGEISIAKSLDYEECSFYEMEIQAEDVGALLGRTKLL 334
Query: 1033 VFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP 1092
+ V+DVND+ P T V E V+ + D D G+N + + + +LP
Sbjct: 335 ISVEDVNDNRPEVIITSLFSPVLENSLPGTVIAFLSVHDQDSGKNGQVVCYTR---DNLP 391
Query: 1093 FEISPLTG---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
F++ G L LDRE Y +TV+A D G D+NDN P
Sbjct: 392 FKLEKSIGNYYRLVTRKYLDRENVSIYNITVMASDLG-TPPLSTETQIALHVADINDNPP 450
Query: 1150 KF 1151
F
Sbjct: 451 TF 452
Score = 77.8 bits (183), Expect = 3e-13
Identities = 58/183 (31%), Positives = 94/183 (51%), Gaps = 22/183 (12%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLD-------SVNGSLFLEKELDLDAEHN 266
+P P A+D D+GV + Y+L S N FSLD ++N L LE+ LD + E
Sbjct: 152 YPLP-EAVDPDVGVNSLQSYQL-SPNHH--FSLDVQTGDNGAINPELVLERALDREEE-- 205
Query: 267 LQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVL 326
A+ VL AS P +++ R+ + +LD NDN P F Y + ++EN+P G +L
Sbjct: 206 -AAHHLVLT--ASDGGKPPRSSTVRIHVTVLDTNDNAPVFPHPIYRVKVLENMPPGTRLL 262
Query: 327 QVMATDKDQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVY 382
V A+D D+G NG+ Y+ + F ++ +G +++ LD E S M++
Sbjct: 263 TVTASDPDEGINGKVAYKFRKINEKQTPLFQLNENTGEISIAKS--LDYEECSFYEMEIQ 320
Query: 383 AKE 385
A++
Sbjct: 321 AED 323
Score = 58.4 bits (135), Expect = 2e-07
Identities = 53/195 (27%), Positives = 89/195 (45%), Gaps = 15/195 (7%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I K LD E+ Y M + AE + G + G ++ I +ED NDN P +
Sbjct: 299 GEISIAKSLDYEECSFYEMEIQAE-DVGALLGRT--KLLISVEDVNDNRPEVIITSLFSP 355
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTG-VVKFIGDS-L 853
++ENS GT I + D D G N + F ++++ G + + L
Sbjct: 356 VLENSLPGTVIAF---LSVHDQDSGKNG--QVVCYTRDNLPFKLEKSIGNYYRLVTRKYL 410
Query: 854 DREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
DRE +Y ++++A D G LS+E ++ + + D NDN P F ++ + E L
Sbjct: 411 DRENVSIYNITVMASDLGTPPLSTETQIALHVADINDNPPTFPHASYSAYI---LENNLR 467
Query: 912 GTAGFTIIEVKPKNK 926
G + F++ P ++
Sbjct: 468 GASIFSLTAHDPDSQ 482
Score = 56.4 bits (130), Expect = 7e-07
Identities = 73/302 (24%), Positives = 125/302 (41%), Gaps = 25/302 (8%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRG 137
S+ + + V + D NDN P+F Y V V E P G + + + +
Sbjct: 223 SSTVRIHVTVLDTNDNAPVFPHPIYRVKVLENMPPGTRLLTVTASDPDEGINGKVAYKFR 282
Query: 138 LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV--LLLRKVLDY---DA 192
K F ++ NT + S+ + + +E + V LL R L D
Sbjct: 283 KINEKQTPLFQLNE-NTGEISIAKSL-DYEECSFYEMEIQAEDVGALLGRTKLLISVEDV 340
Query: 193 GDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGATLRYELISGNDRKLFSLDS 248
D +++I + + + L P + A DQD G + + D F L+
Sbjct: 341 NDNRPEVIITSLFSPVLENSL-PGTVIAFLSVHDQDSGKNGQV---VCYTRDNLPFKLEK 396
Query: 249 VNGSLF-LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFE 307
G+ + L LD E+ + + + V AS L P + + ++ + + D+NDN P F
Sbjct: 397 SIGNYYRLVTRKYLDREN---VSIYNITVMASDLGTPPLSTETQIALHVADINDNPPTFP 453
Query: 308 VDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRN 365
Y+ I+EN G S+ + A D D EN + TY + D +GA P S ++++ +
Sbjct: 454 HASYSAYILENNLRGASIFSLTAHDPDSQENAQVTYSVTEDTLQGA----PLSSYISINS 509
Query: 366 QT 367
T
Sbjct: 510 DT 511
Score = 51.6 bits (118), Expect = 2e-05
Identities = 61/199 (30%), Positives = 91/199 (45%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I EN G +I L A D DS N Q+ Y + + + LS+ Y IN G
Sbjct: 461 ILENNLRGASIFSLTAHDPDSQENAQVTYSVTEDT-LQGAPLSS-------YISINSDTG 512
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK----KTWYN 1051
+ +S E + +L ++A D G+ L+ N+S+ +FV D ND+ P T +
Sbjct: 513 VLYALQSFDYEQIRDLQLLVTASDSGDPPLSSNMSLSLFVLDQNDNAPEILYPALPTDGS 572
Query: 1052 FNVEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG-VLSVNGE 1107
VE A + ++ KV A D D GQNA L+Y + + F + TG V +
Sbjct: 573 TGVELAPRSAERGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAL 632
Query: 1108 LDRETEDKYILTVVARDNG 1126
LDR+ K L V +D+G
Sbjct: 633 LDRDAL-KQSLVVAVQDHG 650
Score = 51.2 bits (117), Expect = 3e-05
Identities = 42/179 (23%), Positives = 80/179 (44%), Gaps = 11/179 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRK--LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A D D G+ + Y+ N+++ LF L+ G + + K LD + + + + ++
Sbjct: 264 VTASDPDEGINGKVAYKFRKINEKQTPLFQLNENTGEISIAKSLDYE-----ECSFYEME 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
+QA + L + + +E D+NDN PE + ++EN G + + D+D
Sbjct: 319 IQAEDVGALLGRTKLLISVE--DVNDNRPEVIITSLFSPVLENSLPGTVIAFLSVHDQDS 376
Query: 336 GENGEFTYQLDDPKGAFSIDPRSG-WLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
G+NG+ D F ++ G + + + LDRE S + V A + + T
Sbjct: 377 GKNGQVVCYTRD-NLPFKLEKSIGNYYRLVTRKYLDRENVSIYNITVMASDLGTPPLST 434
Score = 49.6 bits (113), Expect = 8e-05
Identities = 43/143 (30%), Positives = 69/143 (48%), Gaps = 9/143 (6%)
Query: 221 IDQDLGVG----ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
I +DLG+ A ++S +LF+L+ +GSL +D + E Q+ ++ +
Sbjct: 48 ISKDLGLDPRKLAKHGVRIVSRGRTQLFALNPRSGSLITAGRIDRE-ELCAQSPRCLINI 106
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+ K VEIE++D+NDN P+F+V+ + I E G A D D G
Sbjct: 107 NTLVED---KGKLFGVEIEIIDINDNNPKFQVEDLEVKINEIAVPGARYPLPEAVDPDVG 163
Query: 337 ENGEFTYQLDDPKGAFSIDPRSG 359
N +YQL P FS+D ++G
Sbjct: 164 VNSLQSYQL-SPNHHFSLDVQTG 185
Score = 46.0 bits (104), Expect = 0.001
Identities = 57/218 (26%), Positives = 85/218 (38%), Gaps = 23/218 (10%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
EN GT I L+ D DSG NGQ+ + P KL + Y+ +
Sbjct: 358 ENSLPGTVIAFLSVHDQDSGKNGQVVCYTRDNL---PFKLEKS---IGNYY-------RL 404
Query: 1002 IVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ + L E S + + + A D G L+ + + V D+ND+ P F Y+ + E
Sbjct: 405 VTRKYLDRENVSIYNITVMASDLGTPPLSTETQIALHVADINDNPPTFPHASYSAYILEN 464
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFI-----QPSDTDLPFEISPLTGVLSVNGELDRET 1112
+ + A D D +NA +TY + Q + I+ TGVL D E
Sbjct: 465 NLRGASIFSLTAHDPDSQENAQVTYSVTEDTLQGAPLSSYISINSDTGVLYALQSFDYEQ 524
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
L V A D+G D NDN+P+
Sbjct: 525 IRDLQLLVTASDSG-DPPLSSNMSLSLFVLDQNDNAPE 561
Score = 44.8 bits (101), Expect = 0.002
Identities = 40/138 (28%), Positives = 67/138 (48%), Gaps = 15/138 (10%)
Query: 245 SLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLP 304
S++S G L+ + D + +LQ L V AS +P ++ + + +LD NDN P
Sbjct: 506 SINSDTGVLYALQSFDYEQIRDLQ-----LLVTASDSGDPPLSSNMSLSLFVLDQNDNAP 560
Query: 305 EF---EVDFYNISIVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSID 355
E + + VE P G+ V +V+A D+D G+N +Y+L G FS+
Sbjct: 561 EILYPALPTDGSTGVELAPRSAERGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVG 620
Query: 356 PRSGWLTVRNQTVLDREA 373
+G + + +LDR+A
Sbjct: 621 LHTGEVRTA-RALLDRDA 637
Score = 43.2 bits (97), Expect = 0.007
Identities = 87/419 (20%), Positives = 161/419 (38%), Gaps = 63/419 (15%)
Query: 992 FVINERHGHVIVARSLPPES------EFRLNISAL--DGGNLNDNISVRVFVKDVNDHFP 1043
F +N R G +I A + E +NI+ L D G L V + + D+ND+ P
Sbjct: 75 FALNPRSGSLITAGRIDREELCAQSPRCLININTLVEDKGKL---FGVEIEIIDINDNNP 131
Query: 1044 VFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS---DTDLPF-EISPLT 1099
F+ + E +A D D G N+ +Y + P+ D+ + +
Sbjct: 132 KFQVEDLEVKINEIAVPGARYPLPEAVDPDVGVNSLQSYQLSPNHHFSLDVQTGDNGAIN 191
Query: 1100 GVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLE 1159
L + LDRE E + L + A D G D NDN+P
Sbjct: 192 PELVLERALDREEEAAHHLVLTASDGGKPPRSSTVRIHVTVL-DTNDNAP---------- 240
Query: 1160 WKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLP 1219
V P+Y+ + EN P GT + V A+D D NG + Y
Sbjct: 241 ----------------VFPHPIYRVKVLENMPPGTRLLTVTASDPD--EGINGKVAYKF- 281
Query: 1220 QRKNQQNLGLPSLSSTA--ILMVTVADVPD------EVEMSDKPVFISRYYEL-EIEE-N 1269
++ N++ L L+ I + D + E++ D + R L +E+ N
Sbjct: 282 RKINEKQTPLFQLNENTGEISIAKSLDYEECSFYEMEIQAEDVGALLGRTKLLISVEDVN 341
Query: 1270 VNAPVELVSLNLTEHYENFK----MRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREV 1325
N P +++ + EN + + +++ D+ V R+ + + ++ +
Sbjct: 342 DNRPEVIITSLFSPVLENSLPGTVIAFLSVHDQDSGKNGQVVCYTRDNLPFKL---EKSI 398
Query: 1326 KDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGN 1384
+ Y ++ R + + + + I +A D+ + ++ + + D+NDN P F + +
Sbjct: 399 GNYYRLVTRKYLDRENVSI-YNITVMASDLGTPPLSTETQIALHVADINDNPPTFPHAS 456
Score = 39.1 bits (87), Expect = 0.12
Identities = 38/132 (28%), Positives = 60/132 (45%), Gaps = 13/132 (9%)
Query: 436 DEQLMSFVNVEVTLLDANDNNP-VFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPD 488
D L S +++ + +LD NDN P + P S E + +S A+ G ++ KV AVD D
Sbjct: 539 DPPLSSNMSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRS-AERGYLVTKVVAVDRD 597
Query: 489 LGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPS 546
GQN + Y L + S + F + +TG V A + + + +L V D P
Sbjct: 598 SGQNAWLSYRLLKASEPGL---FSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPL 654
Query: 547 ERRYSLAVVTIE 558
+L V +
Sbjct: 655 SATVTLTVAVAD 666
>AF152328-1|AAD43722.1| 932|Homo sapiens protocadherin gamma A8
protein.
Length = 932
Score = 128 bits (308), Expect = 2e-28
Identities = 134/477 (28%), Positives = 202/477 (42%), Gaps = 35/477 (7%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
NI E VE+ ++D NDNNP F +L E + A G +AVDPD+G
Sbjct: 105 NINTLVEDKGKLFGVEIEIIDINDNNPKFQVEDL-EVKINEIAVPGARYPLPEAVDPDVG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSE 547
N + Y L + ++ N V E + E H L + ASD P
Sbjct: 164 VNSLQSYQLSPNHHFSLDVQTGDNGAINPELVLERALDREEEAAHHLVLTASDGGKPPRS 223
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QND 605
+ V ++ T N P P + Y V N+ GT + + +D E
Sbjct: 224 STVRIHVTVLD----TNDNAPVFPHPI---YRVKVLENMPPGTRLLTVTASDPDEGINGK 276
Query: 606 VSYDLLHGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
V+Y E+ P F + E +G I++ L Y+ E A A L T +
Sbjct: 277 VAYKFRKINEKQTPLFQLNENTGEISIAKSLDYEECSFYEMEIQAEDVGALLGR-TKLLI 335
Query: 665 HVVDVNDERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
V DVND R V++ SP++ ENS + I ++ G V +
Sbjct: 336 SVEDVNDNRPEVIITSLFSPVL----ENSLPGTV--IAFLSVHDQDSGKNGQVVCYTRDN 389
Query: 724 QDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDN 783
+ +I + T+K LDRE +Y +TV+A + G + Q+ +++ D NDN
Sbjct: 390 LPFKLEKSIGNYYRLVTRKYLDRENVSIYNITVMAS-DLGTPPLSTETQIALHVADINDN 448
Query: 784 PPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMY-----TLFGEGKEMF- 837
PP F HA+Y +I+EN+ G I + A D D NA Y TL G +
Sbjct: 449 PPTFPHASYSAYILENNLRGASIFS---LTAHDPDSQENAQVTYSVTEDTLQGAPLSSYI 505
Query: 838 DVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
++ +TGV+ + S D E+ +L + A D+G LSS L + + D+NDN PE
Sbjct: 506 SINSDTGVL-YALQSFDYEQIRDLQLLVTASDSGDPPLSSNMSLSLFVLDQNDNAPE 561
Score = 80.2 bits (189), Expect = 5e-14
Identities = 109/422 (25%), Positives = 173/422 (40%), Gaps = 57/422 (13%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G++ T +DRE+ + N V ++ V I I D NDN P F+ E
Sbjct: 82 GSLITAGRIDREELCAQSPRCLININTLVEDKGKLFGVEIEIIDINDNNPKFQVEDLEVK 141
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
I E + G + +A D D G N+L Y L F +D T GD+
Sbjct: 142 INEIAVPGARYPLP---EAVDPDVGVNSLQSYQL--SPNHHFSLDVQT------GDNGAI 190
Query: 856 EKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAG 915
+++ + +L + EA +++ + KP +S VRIH
Sbjct: 191 NPELVLERALDREE------EAAHHLVLTASDGGKPP-----RSSTVRIH---------- 229
Query: 916 FTIIEVKPKNK-FALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEV 974
T+++ F + ++ L EN+P GT ++ + A D D G+NG++ Y+F
Sbjct: 230 VTVLDTNDNAPVFPHPIYRVKVL----ENMPPGTRLLTVTASDPDEGINGKVAYKFR--- 282
Query: 975 YIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDNISVR 1032
K++ + F +NE G + +A+SL E S + + I A D G L +
Sbjct: 283 -----KINEKQTPL---FQLNENTGEISIAKSLDYEECSFYEMEIQAEDVGALLGRTKLL 334
Query: 1033 VFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP 1092
+ V+DVND+ P T V E V+ + D D G+N + + + +LP
Sbjct: 335 ISVEDVNDNRPEVIITSLFSPVLENSLPGTVIAFLSVHDQDSGKNGQVVCYTR---DNLP 391
Query: 1093 FEISPLTG---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
F++ G L LDRE Y +TV+A D G D+NDN P
Sbjct: 392 FKLEKSIGNYYRLVTRKYLDRENVSIYNITVMASDLG-TPPLSTETQIALHVADINDNPP 450
Query: 1150 KF 1151
F
Sbjct: 451 TF 452
Score = 77.8 bits (183), Expect = 3e-13
Identities = 58/183 (31%), Positives = 94/183 (51%), Gaps = 22/183 (12%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLD-------SVNGSLFLEKELDLDAEHN 266
+P P A+D D+GV + Y+L S N FSLD ++N L LE+ LD + E
Sbjct: 152 YPLP-EAVDPDVGVNSLQSYQL-SPNHH--FSLDVQTGDNGAINPELVLERALDREEE-- 205
Query: 267 LQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVL 326
A+ VL AS P +++ R+ + +LD NDN P F Y + ++EN+P G +L
Sbjct: 206 -AAHHLVLT--ASDGGKPPRSSTVRIHVTVLDTNDNAPVFPHPIYRVKVLENMPPGTRLL 262
Query: 327 QVMATDKDQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVY 382
V A+D D+G NG+ Y+ + F ++ +G +++ LD E S M++
Sbjct: 263 TVTASDPDEGINGKVAYKFRKINEKQTPLFQLNENTGEISIAKS--LDYEECSFYEMEIQ 320
Query: 383 AKE 385
A++
Sbjct: 321 AED 323
Score = 58.4 bits (135), Expect = 2e-07
Identities = 53/195 (27%), Positives = 89/195 (45%), Gaps = 15/195 (7%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I K LD E+ Y M + AE + G + G ++ I +ED NDN P +
Sbjct: 299 GEISIAKSLDYEECSFYEMEIQAE-DVGALLGRT--KLLISVEDVNDNRPEVIITSLFSP 355
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTG-VVKFIGDS-L 853
++ENS GT I + D D G N + F ++++ G + + L
Sbjct: 356 VLENSLPGTVIAF---LSVHDQDSGKNG--QVVCYTRDNLPFKLEKSIGNYYRLVTRKYL 410
Query: 854 DREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
DRE +Y ++++A D G LS+E ++ + + D NDN P F ++ + E L
Sbjct: 411 DRENVSIYNITVMASDLGTPPLSTETQIALHVADINDNPPTFPHASYSAYI---LENNLR 467
Query: 912 GTAGFTIIEVKPKNK 926
G + F++ P ++
Sbjct: 468 GASIFSLTAHDPDSQ 482
Score = 56.4 bits (130), Expect = 7e-07
Identities = 73/302 (24%), Positives = 125/302 (41%), Gaps = 25/302 (8%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRG 137
S+ + + V + D NDN P+F Y V V E P G + + + +
Sbjct: 223 SSTVRIHVTVLDTNDNAPVFPHPIYRVKVLENMPPGTRLLTVTASDPDEGINGKVAYKFR 282
Query: 138 LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV--LLLRKVLDY---DA 192
K F ++ NT + S+ + + +E + V LL R L D
Sbjct: 283 KINEKQTPLFQLNE-NTGEISIAKSL-DYEECSFYEMEIQAEDVGALLGRTKLLISVEDV 340
Query: 193 GDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGATLRYELISGNDRKLFSLDS 248
D +++I + + + L P + A DQD G + + D F L+
Sbjct: 341 NDNRPEVIITSLFSPVLENSL-PGTVIAFLSVHDQDSGKNGQV---VCYTRDNLPFKLEK 396
Query: 249 VNGSLF-LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFE 307
G+ + L LD E+ + + + V AS L P + + ++ + + D+NDN P F
Sbjct: 397 SIGNYYRLVTRKYLDREN---VSIYNITVMASDLGTPPLSTETQIALHVADINDNPPTFP 453
Query: 308 VDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRN 365
Y+ I+EN G S+ + A D D EN + TY + D +GA P S ++++ +
Sbjct: 454 HASYSAYILENNLRGASIFSLTAHDPDSQENAQVTYSVTEDTLQGA----PLSSYISINS 509
Query: 366 QT 367
T
Sbjct: 510 DT 511
Score = 51.6 bits (118), Expect = 2e-05
Identities = 61/199 (30%), Positives = 91/199 (45%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I EN G +I L A D DS N Q+ Y + + + LS+ Y IN G
Sbjct: 461 ILENNLRGASIFSLTAHDPDSQENAQVTYSVTEDT-LQGAPLSS-------YISINSDTG 512
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK----KTWYN 1051
+ +S E + +L ++A D G+ L+ N+S+ +FV D ND+ P T +
Sbjct: 513 VLYALQSFDYEQIRDLQLLVTASDSGDPPLSSNMSLSLFVLDQNDNAPEILYPALPTDGS 572
Query: 1052 FNVEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG-VLSVNGE 1107
VE A + ++ KV A D D GQNA L+Y + + F + TG V +
Sbjct: 573 TGVELAPRSAERGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAL 632
Query: 1108 LDRETEDKYILTVVARDNG 1126
LDR+ K L V +D+G
Sbjct: 633 LDRDAL-KQSLVVAVQDHG 650
Score = 51.2 bits (117), Expect = 3e-05
Identities = 42/179 (23%), Positives = 80/179 (44%), Gaps = 11/179 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRK--LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A D D G+ + Y+ N+++ LF L+ G + + K LD + + + + ++
Sbjct: 264 VTASDPDEGINGKVAYKFRKINEKQTPLFQLNENTGEISIAKSLDYE-----ECSFYEME 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
+QA + L + + +E D+NDN PE + ++EN G + + D+D
Sbjct: 319 IQAEDVGALLGRTKLLISVE--DVNDNRPEVIITSLFSPVLENSLPGTVIAFLSVHDQDS 376
Query: 336 GENGEFTYQLDDPKGAFSIDPRSG-WLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
G+NG+ D F ++ G + + + LDRE S + V A + + T
Sbjct: 377 GKNGQVVCYTRD-NLPFKLEKSIGNYYRLVTRKYLDRENVSIYNITVMASDLGTPPLST 434
Score = 49.6 bits (113), Expect = 8e-05
Identities = 43/143 (30%), Positives = 69/143 (48%), Gaps = 9/143 (6%)
Query: 221 IDQDLGVG----ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
I +DLG+ A ++S +LF+L+ +GSL +D + E Q+ ++ +
Sbjct: 48 ISKDLGLDPRKLAKHGVRIVSRGRTQLFALNPRSGSLITAGRIDRE-ELCAQSPRCLINI 106
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+ K VEIE++D+NDN P+F+V+ + I E G A D D G
Sbjct: 107 NTLVED---KGKLFGVEIEIIDINDNNPKFQVEDLEVKINEIAVPGARYPLPEAVDPDVG 163
Query: 337 ENGEFTYQLDDPKGAFSIDPRSG 359
N +YQL P FS+D ++G
Sbjct: 164 VNSLQSYQL-SPNHHFSLDVQTG 185
Score = 46.0 bits (104), Expect = 0.001
Identities = 57/218 (26%), Positives = 85/218 (38%), Gaps = 23/218 (10%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
EN GT I L+ D DSG NGQ+ + P KL + Y+ +
Sbjct: 358 ENSLPGTVIAFLSVHDQDSGKNGQVVCYTRDNL---PFKLEKS---IGNYY-------RL 404
Query: 1002 IVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ + L E S + + + A D G L+ + + V D+ND+ P F Y+ + E
Sbjct: 405 VTRKYLDRENVSIYNITVMASDLGTPPLSTETQIALHVADINDNPPTFPHASYSAYILEN 464
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFI-----QPSDTDLPFEISPLTGVLSVNGELDRET 1112
+ + A D D +NA +TY + Q + I+ TGVL D E
Sbjct: 465 NLRGASIFSLTAHDPDSQENAQVTYSVTEDTLQGAPLSSYISINSDTGVLYALQSFDYEQ 524
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
L V A D+G D NDN+P+
Sbjct: 525 IRDLQLLVTASDSG-DPPLSSNMSLSLFVLDQNDNAPE 561
Score = 44.8 bits (101), Expect = 0.002
Identities = 40/138 (28%), Positives = 67/138 (48%), Gaps = 15/138 (10%)
Query: 245 SLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLP 304
S++S G L+ + D + +LQ L V AS +P ++ + + +LD NDN P
Sbjct: 506 SINSDTGVLYALQSFDYEQIRDLQ-----LLVTASDSGDPPLSSNMSLSLFVLDQNDNAP 560
Query: 305 EF---EVDFYNISIVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSID 355
E + + VE P G+ V +V+A D+D G+N +Y+L G FS+
Sbjct: 561 EILYPALPTDGSTGVELAPRSAERGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVG 620
Query: 356 PRSGWLTVRNQTVLDREA 373
+G + + +LDR+A
Sbjct: 621 LHTGEVRTA-RALLDRDA 637
Score = 43.2 bits (97), Expect = 0.007
Identities = 87/419 (20%), Positives = 161/419 (38%), Gaps = 63/419 (15%)
Query: 992 FVINERHGHVIVARSLPPES------EFRLNISAL--DGGNLNDNISVRVFVKDVNDHFP 1043
F +N R G +I A + E +NI+ L D G L V + + D+ND+ P
Sbjct: 75 FALNPRSGSLITAGRIDREELCAQSPRCLININTLVEDKGKL---FGVEIEIIDINDNNP 131
Query: 1044 VFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS---DTDLPF-EISPLT 1099
F+ + E +A D D G N+ +Y + P+ D+ + +
Sbjct: 132 KFQVEDLEVKINEIAVPGARYPLPEAVDPDVGVNSLQSYQLSPNHHFSLDVQTGDNGAIN 191
Query: 1100 GVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLE 1159
L + LDRE E + L + A D G D NDN+P
Sbjct: 192 PELVLERALDREEEAAHHLVLTASDGGKPPRSSTVRIHVTVL-DTNDNAP---------- 240
Query: 1160 WKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLP 1219
V P+Y+ + EN P GT + V A+D D NG + Y
Sbjct: 241 ----------------VFPHPIYRVKVLENMPPGTRLLTVTASDPD--EGINGKVAYKF- 281
Query: 1220 QRKNQQNLGLPSLSSTA--ILMVTVADVPD------EVEMSDKPVFISRYYEL-EIEE-N 1269
++ N++ L L+ I + D + E++ D + R L +E+ N
Sbjct: 282 RKINEKQTPLFQLNENTGEISIAKSLDYEECSFYEMEIQAEDVGALLGRTKLLISVEDVN 341
Query: 1270 VNAPVELVSLNLTEHYENFK----MRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREV 1325
N P +++ + EN + + +++ D+ V R+ + + ++ +
Sbjct: 342 DNRPEVIITSLFSPVLENSLPGTVIAFLSVHDQDSGKNGQVVCYTRDNLPFKL---EKSI 398
Query: 1326 KDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGN 1384
+ Y ++ R + + + + I +A D+ + ++ + + D+NDN P F + +
Sbjct: 399 GNYYRLVTRKYLDRENVSI-YNITVMASDLGTPPLSTETQIALHVADINDNPPTFPHAS 456
Score = 39.1 bits (87), Expect = 0.12
Identities = 38/132 (28%), Positives = 60/132 (45%), Gaps = 13/132 (9%)
Query: 436 DEQLMSFVNVEVTLLDANDNNP-VFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPD 488
D L S +++ + +LD NDN P + P S E + +S A+ G ++ KV AVD D
Sbjct: 539 DPPLSSNMSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRS-AERGYLVTKVVAVDRD 597
Query: 489 LGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPS 546
GQN + Y L + S + F + +TG V A + + + +L V D P
Sbjct: 598 SGQNAWLSYRLLKASEPGL---FSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPL 654
Query: 547 ERRYSLAVVTIE 558
+L V +
Sbjct: 655 SATVTLTVAVAD 666
>AB002325-1|BAA20785.2| 898|Homo sapiens KIAA0327 protein protein.
Length = 898
Score = 128 bits (308), Expect = 2e-28
Identities = 134/477 (28%), Positives = 202/477 (42%), Gaps = 35/477 (7%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
NI E VE+ ++D NDNNP F +L E + A G +AVDPD+G
Sbjct: 183 NINTLVEDKGKLFGVEIEIIDINDNNPKFQVEDL-EVKINEIAVPGARYPLPEAVDPDVG 241
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSE 547
N + Y L + ++ N V E + E H L + ASD P
Sbjct: 242 VNSLQSYQLSPNHHFSLDVQTGDNGAINPELVLERALDREEEAAHHLVLTASDGGKPPRS 301
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QND 605
+ V ++ T N P P + Y V N+ GT + + +D E
Sbjct: 302 STVRIHVTVLD----TNDNAPVFPHPI---YRVKVLENMPPGTRLLTVTASDPDEGINGK 354
Query: 606 VSYDLLHGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
V+Y E+ P F + E +G I++ L Y+ E A A L T +
Sbjct: 355 VAYKFRKINEKQTPLFQLNENTGEISIAKSLDYEECSFYEMEIQAEDVGALLGR-TKLLI 413
Query: 665 HVVDVNDERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
V DVND R V++ SP++ ENS + I ++ G V +
Sbjct: 414 SVEDVNDNRPEVIITSLFSPVL----ENSLPGTV--IAFLSVHDQDSGKNGQVVCYTRDN 467
Query: 724 QDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDN 783
+ +I + T+K LDRE +Y +TV+A + G + Q+ +++ D NDN
Sbjct: 468 LPFKLEKSIGNYYRLVTRKYLDRENVSIYNITVMAS-DLGTPPLSTETQIALHVADINDN 526
Query: 784 PPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMY-----TLFGEGKEMF- 837
PP F HA+Y +I+EN+ G I + A D D NA Y TL G +
Sbjct: 527 PPTFPHASYSAYILENNLRGASIFS---LTAHDPDSQENAQVTYSVTEDTLQGAPLSSYI 583
Query: 838 DVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
++ +TGV+ + S D E+ +L + A D+G LSS L + + D+NDN PE
Sbjct: 584 SINSDTGVL-YALQSFDYEQIRDLQLLVTASDSGDPPLSSNMSLSLFVLDQNDNAPE 639
Score = 80.2 bits (189), Expect = 5e-14
Identities = 109/422 (25%), Positives = 173/422 (40%), Gaps = 57/422 (13%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G++ T +DRE+ + N V ++ V I I D NDN P F+ E
Sbjct: 160 GSLITAGRIDREELCAQSPRCLININTLVEDKGKLFGVEIEIIDINDNNPKFQVEDLEVK 219
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
I E + G + +A D D G N+L Y L F +D T GD+
Sbjct: 220 INEIAVPGARYPLP---EAVDPDVGVNSLQSYQL--SPNHHFSLDVQT------GDNGAI 268
Query: 856 EKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAG 915
+++ + +L + EA +++ + KP +S VRIH
Sbjct: 269 NPELVLERALDREE------EAAHHLVLTASDGGKPP-----RSSTVRIH---------- 307
Query: 916 FTIIEVKPKNK-FALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEV 974
T+++ F + ++ L EN+P GT ++ + A D D G+NG++ Y+F
Sbjct: 308 VTVLDTNDNAPVFPHPIYRVKVL----ENMPPGTRLLTVTASDPDEGINGKVAYKFR--- 360
Query: 975 YIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDNISVR 1032
K++ + F +NE G + +A+SL E S + + I A D G L +
Sbjct: 361 -----KINEKQTPL---FQLNENTGEISIAKSLDYEECSFYEMEIQAEDVGALLGRTKLL 412
Query: 1033 VFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP 1092
+ V+DVND+ P T V E V+ + D D G+N + + + +LP
Sbjct: 413 ISVEDVNDNRPEVIITSLFSPVLENSLPGTVIAFLSVHDQDSGKNGQVVCYTR---DNLP 469
Query: 1093 FEISPLTG---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
F++ G L LDRE Y +TV+A D G D+NDN P
Sbjct: 470 FKLEKSIGNYYRLVTRKYLDRENVSIYNITVMASDLG-TPPLSTETQIALHVADINDNPP 528
Query: 1150 KF 1151
F
Sbjct: 529 TF 530
Score = 77.8 bits (183), Expect = 3e-13
Identities = 58/183 (31%), Positives = 94/183 (51%), Gaps = 22/183 (12%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLD-------SVNGSLFLEKELDLDAEHN 266
+P P A+D D+GV + Y+L S N FSLD ++N L LE+ LD + E
Sbjct: 230 YPLP-EAVDPDVGVNSLQSYQL-SPNHH--FSLDVQTGDNGAINPELVLERALDREEE-- 283
Query: 267 LQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVL 326
A+ VL AS P +++ R+ + +LD NDN P F Y + ++EN+P G +L
Sbjct: 284 -AAHHLVLT--ASDGGKPPRSSTVRIHVTVLDTNDNAPVFPHPIYRVKVLENMPPGTRLL 340
Query: 327 QVMATDKDQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVY 382
V A+D D+G NG+ Y+ + F ++ +G +++ LD E S M++
Sbjct: 341 TVTASDPDEGINGKVAYKFRKINEKQTPLFQLNENTGEISIAKS--LDYEECSFYEMEIQ 398
Query: 383 AKE 385
A++
Sbjct: 399 AED 401
Score = 58.4 bits (135), Expect = 2e-07
Identities = 53/195 (27%), Positives = 89/195 (45%), Gaps = 15/195 (7%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I K LD E+ Y M + AE + G + G ++ I +ED NDN P +
Sbjct: 377 GEISIAKSLDYEECSFYEMEIQAE-DVGALLGRT--KLLISVEDVNDNRPEVIITSLFSP 433
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTG-VVKFIGDS-L 853
++ENS GT I + D D G N + F ++++ G + + L
Sbjct: 434 VLENSLPGTVIAF---LSVHDQDSGKNG--QVVCYTRDNLPFKLEKSIGNYYRLVTRKYL 488
Query: 854 DREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
DRE +Y ++++A D G LS+E ++ + + D NDN P F ++ + E L
Sbjct: 489 DRENVSIYNITVMASDLGTPPLSTETQIALHVADINDNPPTFPHASYSAYI---LENNLR 545
Query: 912 GTAGFTIIEVKPKNK 926
G + F++ P ++
Sbjct: 546 GASIFSLTAHDPDSQ 560
Score = 56.4 bits (130), Expect = 7e-07
Identities = 73/302 (24%), Positives = 125/302 (41%), Gaps = 25/302 (8%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRG 137
S+ + + V + D NDN P+F Y V V E P G + + + +
Sbjct: 301 SSTVRIHVTVLDTNDNAPVFPHPIYRVKVLENMPPGTRLLTVTASDPDEGINGKVAYKFR 360
Query: 138 LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV--LLLRKVLDY---DA 192
K F ++ NT + S+ + + +E + V LL R L D
Sbjct: 361 KINEKQTPLFQLNE-NTGEISIAKSL-DYEECSFYEMEIQAEDVGALLGRTKLLISVEDV 418
Query: 193 GDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGATLRYELISGNDRKLFSLDS 248
D +++I + + + L P + A DQD G + + D F L+
Sbjct: 419 NDNRPEVIITSLFSPVLENSL-PGTVIAFLSVHDQDSGKNGQV---VCYTRDNLPFKLEK 474
Query: 249 VNGSLF-LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFE 307
G+ + L LD E+ + + + V AS L P + + ++ + + D+NDN P F
Sbjct: 475 SIGNYYRLVTRKYLDREN---VSIYNITVMASDLGTPPLSTETQIALHVADINDNPPTFP 531
Query: 308 VDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRN 365
Y+ I+EN G S+ + A D D EN + TY + D +GA P S ++++ +
Sbjct: 532 HASYSAYILENNLRGASIFSLTAHDPDSQENAQVTYSVTEDTLQGA----PLSSYISINS 587
Query: 366 QT 367
T
Sbjct: 588 DT 589
Score = 51.6 bits (118), Expect = 2e-05
Identities = 61/199 (30%), Positives = 91/199 (45%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I EN G +I L A D DS N Q+ Y + + + LS+ Y IN G
Sbjct: 539 ILENNLRGASIFSLTAHDPDSQENAQVTYSVTEDT-LQGAPLSS-------YISINSDTG 590
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK----KTWYN 1051
+ +S E + +L ++A D G+ L+ N+S+ +FV D ND+ P T +
Sbjct: 591 VLYALQSFDYEQIRDLQLLVTASDSGDPPLSSNMSLSLFVLDQNDNAPEILYPALPTDGS 650
Query: 1052 FNVEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG-VLSVNGE 1107
VE A + ++ KV A D D GQNA L+Y + + F + TG V +
Sbjct: 651 TGVELAPRSAERGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAL 710
Query: 1108 LDRETEDKYILTVVARDNG 1126
LDR+ K L V +D+G
Sbjct: 711 LDRDAL-KQSLVVAVQDHG 728
Score = 51.2 bits (117), Expect = 3e-05
Identities = 42/179 (23%), Positives = 80/179 (44%), Gaps = 11/179 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRK--LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A D D G+ + Y+ N+++ LF L+ G + + K LD + + + + ++
Sbjct: 342 VTASDPDEGINGKVAYKFRKINEKQTPLFQLNENTGEISIAKSLDYE-----ECSFYEME 396
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
+QA + L + + +E D+NDN PE + ++EN G + + D+D
Sbjct: 397 IQAEDVGALLGRTKLLISVE--DVNDNRPEVIITSLFSPVLENSLPGTVIAFLSVHDQDS 454
Query: 336 GENGEFTYQLDDPKGAFSIDPRSG-WLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
G+NG+ D F ++ G + + + LDRE S + V A + + T
Sbjct: 455 GKNGQVVCYTRD-NLPFKLEKSIGNYYRLVTRKYLDRENVSIYNITVMASDLGTPPLST 512
Score = 49.6 bits (113), Expect = 8e-05
Identities = 43/143 (30%), Positives = 69/143 (48%), Gaps = 9/143 (6%)
Query: 221 IDQDLGVG----ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
I +DLG+ A ++S +LF+L+ +GSL +D + E Q+ ++ +
Sbjct: 126 ISKDLGLDPRKLAKHGVRIVSRGRTQLFALNPRSGSLITAGRIDRE-ELCAQSPRCLINI 184
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+ K VEIE++D+NDN P+F+V+ + I E G A D D G
Sbjct: 185 NTLVED---KGKLFGVEIEIIDINDNNPKFQVEDLEVKINEIAVPGARYPLPEAVDPDVG 241
Query: 337 ENGEFTYQLDDPKGAFSIDPRSG 359
N +YQL P FS+D ++G
Sbjct: 242 VNSLQSYQL-SPNHHFSLDVQTG 263
Score = 46.0 bits (104), Expect = 0.001
Identities = 57/218 (26%), Positives = 85/218 (38%), Gaps = 23/218 (10%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
EN GT I L+ D DSG NGQ+ + P KL + Y+ +
Sbjct: 436 ENSLPGTVIAFLSVHDQDSGKNGQVVCYTRDNL---PFKLEKS---IGNYY-------RL 482
Query: 1002 IVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ + L E S + + + A D G L+ + + V D+ND+ P F Y+ + E
Sbjct: 483 VTRKYLDRENVSIYNITVMASDLGTPPLSTETQIALHVADINDNPPTFPHASYSAYILEN 542
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFI-----QPSDTDLPFEISPLTGVLSVNGELDRET 1112
+ + A D D +NA +TY + Q + I+ TGVL D E
Sbjct: 543 NLRGASIFSLTAHDPDSQENAQVTYSVTEDTLQGAPLSSYISINSDTGVLYALQSFDYEQ 602
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
L V A D+G D NDN+P+
Sbjct: 603 IRDLQLLVTASDSG-DPPLSSNMSLSLFVLDQNDNAPE 639
Score = 44.8 bits (101), Expect = 0.002
Identities = 40/138 (28%), Positives = 67/138 (48%), Gaps = 15/138 (10%)
Query: 245 SLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLP 304
S++S G L+ + D + +LQ L V AS +P ++ + + +LD NDN P
Sbjct: 584 SINSDTGVLYALQSFDYEQIRDLQ-----LLVTASDSGDPPLSSNMSLSLFVLDQNDNAP 638
Query: 305 EF---EVDFYNISIVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSID 355
E + + VE P G+ V +V+A D+D G+N +Y+L G FS+
Sbjct: 639 EILYPALPTDGSTGVELAPRSAERGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVG 698
Query: 356 PRSGWLTVRNQTVLDREA 373
+G + + +LDR+A
Sbjct: 699 LHTGEVRTA-RALLDRDA 715
Score = 43.2 bits (97), Expect = 0.007
Identities = 87/419 (20%), Positives = 161/419 (38%), Gaps = 63/419 (15%)
Query: 992 FVINERHGHVIVARSLPPES------EFRLNISAL--DGGNLNDNISVRVFVKDVNDHFP 1043
F +N R G +I A + E +NI+ L D G L V + + D+ND+ P
Sbjct: 153 FALNPRSGSLITAGRIDREELCAQSPRCLININTLVEDKGKL---FGVEIEIIDINDNNP 209
Query: 1044 VFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS---DTDLPF-EISPLT 1099
F+ + E +A D D G N+ +Y + P+ D+ + +
Sbjct: 210 KFQVEDLEVKINEIAVPGARYPLPEAVDPDVGVNSLQSYQLSPNHHFSLDVQTGDNGAIN 269
Query: 1100 GVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLE 1159
L + LDRE E + L + A D G D NDN+P
Sbjct: 270 PELVLERALDREEEAAHHLVLTASDGGKPPRSSTVRIHVTVL-DTNDNAP---------- 318
Query: 1160 WKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLP 1219
V P+Y+ + EN P GT + V A+D D NG + Y
Sbjct: 319 ----------------VFPHPIYRVKVLENMPPGTRLLTVTASDPD--EGINGKVAYKF- 359
Query: 1220 QRKNQQNLGLPSLSSTA--ILMVTVADVPD------EVEMSDKPVFISRYYEL-EIEE-N 1269
++ N++ L L+ I + D + E++ D + R L +E+ N
Sbjct: 360 RKINEKQTPLFQLNENTGEISIAKSLDYEECSFYEMEIQAEDVGALLGRTKLLISVEDVN 419
Query: 1270 VNAPVELVSLNLTEHYENFK----MRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREV 1325
N P +++ + EN + + +++ D+ V R+ + + ++ +
Sbjct: 420 DNRPEVIITSLFSPVLENSLPGTVIAFLSVHDQDSGKNGQVVCYTRDNLPFKL---EKSI 476
Query: 1326 KDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGN 1384
+ Y ++ R + + + + I +A D+ + ++ + + D+NDN P F + +
Sbjct: 477 GNYYRLVTRKYLDRENVSI-YNITVMASDLGTPPLSTETQIALHVADINDNPPTFPHAS 534
Score = 39.1 bits (87), Expect = 0.12
Identities = 38/132 (28%), Positives = 60/132 (45%), Gaps = 13/132 (9%)
Query: 436 DEQLMSFVNVEVTLLDANDNNP-VFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPD 488
D L S +++ + +LD NDN P + P S E + +S A+ G ++ KV AVD D
Sbjct: 617 DPPLSSNMSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRS-AERGYLVTKVVAVDRD 675
Query: 489 LGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPS 546
GQN + Y L + S + F + +TG V A + + + +L V D P
Sbjct: 676 SGQNAWLSYRLLKASEPGL---FSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPL 732
Query: 547 ERRYSLAVVTIE 558
+L V +
Sbjct: 733 SATVTLTVAVAD 744
>AF152505-1|AAD43766.1| 837|Homo sapiens protocadherin gamma A11
short form protein protein.
Length = 837
Score = 127 bits (307), Expect = 3e-28
Identities = 126/476 (26%), Positives = 196/476 (41%), Gaps = 33/476 (6%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
N+E E + VEV ++D NDN P F + E + +A G A DPD+G
Sbjct: 106 NMELLVEDTLKIYGVEVEIIDINDNAPSFQEDEV-EIKVSEHAIPGARFALPNARDPDVG 164
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSE 547
N + Y L + ++ + + V E + E H L + A D +
Sbjct: 165 VNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRK 224
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QND 605
+ VV ++V IP F + Y V N+ GT V + D E +
Sbjct: 225 GAVPIRVVVLDVN-------DHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGE 277
Query: 606 VSYDLLHGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
V Y + + F ++ ++G + V L Y+ E + Q+ L T +
Sbjct: 278 VMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEME-IQGQDGGGLFTTTTMLI 336
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
VVDVND + + I + ENS + I N+ G V I N
Sbjct: 337 TVVDVNDNAPEI---TITSSINSILENSPPGTV--IALLNVQDQDSGENGQVSCFIPNHL 391
Query: 725 DVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
+ + T + LDRE Y +T+ A ++G + V + + D+NDNP
Sbjct: 392 PFKLEKTYGNYYKLITSRVLDRELVQSYNITLTAT-DQGSPPLSAETHVWLNVADDNDNP 450
Query: 785 PVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFD 838
PVF H++Y +I EN+ G I + A D D NAL Y+L +
Sbjct: 451 PVFPHSSYSAYIPENNPRGASIFS---VTALDPDSKQNALVTYSLTDDTVQGVPLSSYVS 507
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
++ NTGV+ + S D E+ +L ++ARD+G LSS L + + D+NDN PE
Sbjct: 508 INSNTGVL-YALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPE 562
Score = 80.6 bits (190), Expect = 4e-14
Identities = 64/217 (29%), Positives = 97/217 (44%), Gaps = 20/217 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PENI GT ++ +NA D D G+NG++ Y F + + + A E+ F ++ + G
Sbjct: 252 VPENISSGTRVLMVNATDPDEGINGEVMYSFRN--------MESKASEI---FQLDSQTG 300
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
V V SL E + + I DGG L ++ + V DVND+ P T ++ E
Sbjct: 301 EVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILEN 360
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
V+ ++ D D G+N ++ FI LPF++ G L + LDRE
Sbjct: 361 SPPGTVIALLNVQDQDSGENGQVSCFI---PNHLPFKLEKTYGNYYKLITSRVLDRELVQ 417
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
Y +T+ A D G D NDN P F
Sbjct: 418 SYNITLTATDQGSPPLSAETHVWLNVADD-NDNPPVF 453
Score = 72.9 bits (171), Expect = 8e-12
Identities = 48/171 (28%), Positives = 84/171 (49%), Gaps = 7/171 (4%)
Query: 219 HAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQA 278
+A D D+GV + Y+L N L +G+ E L+ + +A +L + A
Sbjct: 157 NARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKEA-AHLLLLTA 215
Query: 279 SQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGEN 338
+P++ + + +LD+ND++P F Y +S+ EN+ +G VL V ATD D+G N
Sbjct: 216 LDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGIN 275
Query: 339 GEFTYQLDDPKG----AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
GE Y + + F +D ++G + VR LD E + M++ ++
Sbjct: 276 GEVMYSFRNMESKASEIFQLDSQTGEVQVRGS--LDFEKYRFYEMEIQGQD 324
Score = 68.1 bits (159), Expect = 2e-10
Identities = 61/204 (29%), Positives = 94/204 (46%), Gaps = 20/204 (9%)
Query: 954 NALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEF 1013
NA D D G+N Y+ + Y +L++ R ++ +++ SL E E
Sbjct: 157 NARDPDVGVNSLQSYQLSPNNYF--------SLQL-RGRTDGAKNPELVLEGSLDREKEA 207
Query: 1014 R--LNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVD 1068
L ++ALDGG+ + +RV V DVNDH P+F ++ Y +V E RVL V+
Sbjct: 208 AHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVL-MVN 266
Query: 1069 ATDADFGQNANLTYFIQPSDTDLP--FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
ATD D G N + Y + ++ F++ TG + V G LD E Y + + +D G
Sbjct: 267 ATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGG 326
Query: 1127 XXXXXXXXXXXXXXXXDVNDNSPK 1150
DVNDN+P+
Sbjct: 327 ---GLFTTTTMLITVVDVNDNAPE 347
Score = 61.7 bits (143), Expect = 2e-08
Identities = 68/269 (25%), Positives = 112/269 (41%), Gaps = 22/269 (8%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
V V+DVND + + + V EN + ++ N + G V + N
Sbjct: 231 VVVLDVNDHIPMFTQSVYR---VSVPENISSGT--RVLMVNATDPDEGINGEVMYSFRNM 285
Query: 724 QDVTDDI--AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
+ +I ++ G + + LD EK Y M + + G+ + + I + D N
Sbjct: 286 ESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTT---TMLITVVDVN 342
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDE 841
DN P + I+ENS GT I + N+ D D G N + F F +++
Sbjct: 343 DNAPEITITSSINSILENSPPGTVIALLNV---QDQDSGENG--QVSCFIPNHLPFKLEK 397
Query: 842 NTG-VVKFIGDS-LDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
G K I LDRE Y ++L A D G LS+E + + + D+NDN P F
Sbjct: 398 TYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSS 457
Query: 898 ENSKVRIHRETKLNGTAGFTIIEVKPKNK 926
++ + E G + F++ + P +K
Sbjct: 458 YSAYI---PENNPRGASIFSVTALDPDSK 483
Score = 61.3 bits (142), Expect = 3e-08
Identities = 60/199 (30%), Positives = 89/199 (44%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P G +I + ALD DS N + Y + + + + Y IN G
Sbjct: 462 IPENNPRGASIFSVTALDPDSKQNALVTYSLTDD--------TVQGVPLSSYVSINSNTG 513
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK----KTWYN 1051
+ +S E + L + A D G+ L+ N+S+ +FV D ND+ P T +
Sbjct: 514 VLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGS 573
Query: 1052 FNVEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG-VLSVNGE 1107
VE A + ++ KV A D D GQNA L+Y + + F + TG V +
Sbjct: 574 TGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARAL 633
Query: 1108 LDRETEDKYILTVVARDNG 1126
LDR+ K L V +D+G
Sbjct: 634 LDRDAL-KQSLVVAVQDHG 651
Score = 60.9 bits (141), Expect = 3e-08
Identities = 70/240 (29%), Positives = 101/240 (42%), Gaps = 19/240 (7%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
+I V N A ++ + I EN P GT I LN D DSG NGQ+ + +
Sbjct: 335 LITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHL--- 391
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFV 1035
P KL + Y +I R ++ R L + + ++A D G+ L+ V + V
Sbjct: 392 PFKL--EKTYGNYYKLITSR----VLDREL--VQSYNITLTATDQGSPPLSAETHVWLNV 443
Query: 1036 KDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTD-LPF- 1093
D ND+ PVF + Y+ + E + V A D D QNA +TY + +P
Sbjct: 444 ADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLS 503
Query: 1094 ---EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
I+ TGVL D E L V+ARD+G D NDN+P+
Sbjct: 504 SYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSG-DPPLSSNVSLSLFVLDQNDNAPE 562
Score = 53.6 bits (123), Expect = 5e-06
Identities = 44/171 (25%), Positives = 79/171 (46%), Gaps = 11/171 (6%)
Query: 218 IHAIDQDLGVGATLRYEL--ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
++A D D G+ + Y + ++F LDS G + + LD + + + ++
Sbjct: 265 VNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFE-----KYRFYEME 319
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
+Q Q L T + I ++D+NDN PE + SI+EN P G + + D+D
Sbjct: 320 IQG-QDGGGLFTTTTML-ITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDS 377
Query: 336 GENGEFTYQLDDPKGAFSIDPRSG-WLTVRNQTVLDREAHSSLRMKVYAKE 385
GENG+ + + + F ++ G + + VLDRE S + + A +
Sbjct: 378 GENGQVSCFIPNHL-PFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATD 427
Score = 50.4 bits (115), Expect = 5e-05
Identities = 36/123 (29%), Positives = 58/123 (47%), Gaps = 9/123 (7%)
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
++ + + A+ +P +A+ V + + D NDN P F Y+ I EN P G S+ V A
Sbjct: 418 SYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTA 477
Query: 331 TDKDQGENGEFTYQLDD------PKGAF-SIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
D D +N TY L D P ++ SI+ +G L D E L ++V A
Sbjct: 478 LDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQS--FDYEQFRDLELRVIA 535
Query: 384 KET 386
+++
Sbjct: 536 RDS 538
Score = 47.6 bits (108), Expect = 3e-04
Identities = 41/141 (29%), Positives = 67/141 (47%), Gaps = 9/141 (6%)
Query: 221 IDQDLGVG----ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
I +DLG+ A ++S +LF+++ +GSL +D + ++ F L +
Sbjct: 49 ISKDLGLEPRELAKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCF-LNM 107
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+ + + LK VE+E++D+NDN P F+ D I + E+ G A D D G
Sbjct: 108 ELL-VEDTLKIYG--VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVG 164
Query: 337 ENGEFTYQLDDPKGAFSIDPR 357
N +YQL P FS+ R
Sbjct: 165 VNSLQSYQL-SPNNYFSLQLR 184
Score = 44.0 bits (99), Expect = 0.004
Identities = 45/170 (26%), Positives = 79/170 (46%), Gaps = 20/170 (11%)
Query: 218 IHAIDQDLGVGATLRYEL----ISGNDRKLF-SLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A+D D A + Y L + G + S++S G L+ + D + +L+
Sbjct: 475 VTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLE---- 530
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLPN----GFSV 325
L+V A +P ++ + + +LD NDN PE + + VE P G+ V
Sbjct: 531 -LRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLV 589
Query: 326 LQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREA 373
+V+A DKD G+N +Y+L G F++ +G + + +LDR+A
Sbjct: 590 TKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTA-RALLDRDA 638
Score = 43.2 bits (97), Expect = 0.007
Identities = 46/171 (26%), Positives = 68/171 (39%), Gaps = 14/171 (8%)
Query: 992 FVINERHGHVIVARSLPPE------SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVF 1045
F +N R G +I A + E S LN+ L L V V + D+ND+ P F
Sbjct: 76 FAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKI-YGVEVEIIDINDNAPSF 134
Query: 1046 KKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG----- 1100
++ V E +A D D G N+ +Y + P++ ++ T
Sbjct: 135 QEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNY-FSLQLRGRTDGAKNP 193
Query: 1101 VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
L + G LDRE E ++L + A D G DVND+ P F
Sbjct: 194 ELVLEGSLDREKEAAHLLLLTALDGG-DPIRKGAVPIRVVVLDVNDHIPMF 243
Score = 41.5 bits (93), Expect = 0.022
Identities = 39/132 (29%), Positives = 60/132 (45%), Gaps = 13/132 (9%)
Query: 436 DEQLMSFVNVEVTLLDANDNNP-VFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPD 488
D L S V++ + +LD NDN P + P S E + +S A+ G ++ KV AVD D
Sbjct: 540 DPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRS-AEPGYLVTKVVAVDKD 598
Query: 489 LGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPS 546
GQN + Y L + S + F + +TG V A + + + +L V D P
Sbjct: 599 SGQNAWLSYRLLKASEPGL---FAVGEHTGEVRTARALLDRDALKQSLVVAVQDHGQPPL 655
Query: 547 ERRYSLAVVTIE 558
+L V +
Sbjct: 656 SATVTLTVAVAD 667
Score = 35.1 bits (77), Expect = 2.0
Identities = 62/302 (20%), Positives = 111/302 (36%), Gaps = 25/302 (8%)
Query: 1093 FEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY 1152
F ++P +G L G +DRE + + + D+NDN+P F
Sbjct: 76 FAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPSFQ 135
Query: 1153 AFD-ELLEWKH--PEAD-ELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIG 1208
+ E+ +H P A L N V + + + N + TD
Sbjct: 136 EDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLR----GRTDGAK 191
Query: 1209 NGNGLILYSLPQRKNQQNL--------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISR 1260
N ++ SL + K +L G P + V V DV D + P+F
Sbjct: 192 NPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHI-----PMFTQS 246
Query: 1261 YYELEIEENVNAPVELVSLNLTEHYENFKMR-YYILNENDTDIRRTFVIDPRNGTLYLVR 1319
Y + + EN+++ ++ +N T+ E Y ++ F +D + G + +
Sbjct: 247 VYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRG 306
Query: 1320 SPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPK 1379
S D E YE+ ++ + M+ V DV + ++ + I + +NSP
Sbjct: 307 SLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVV-DVNDNAP--EITITSSINSILENSPP 363
Query: 1380 FT 1381
T
Sbjct: 364 GT 365
>AF152504-1|AAD43765.1| 750|Homo sapiens protocadherin gamma A11
protein.
Length = 750
Score = 127 bits (307), Expect = 3e-28
Identities = 126/476 (26%), Positives = 196/476 (41%), Gaps = 33/476 (6%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
N+E E + VEV ++D NDN P F + E + +A G A DPD+G
Sbjct: 106 NMELLVEDTLKIYGVEVEIIDINDNAPSFQEDEV-EIKVSEHAIPGARFALPNARDPDVG 164
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSE 547
N + Y L + ++ + + V E + E H L + A D +
Sbjct: 165 VNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRK 224
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QND 605
+ VV ++V IP F + Y V N+ GT V + D E +
Sbjct: 225 GAVPIRVVVLDVN-------DHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGE 277
Query: 606 VSYDLLHGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
V Y + + F ++ ++G + V L Y+ E + Q+ L T +
Sbjct: 278 VMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEME-IQGQDGGGLFTTTTMLI 336
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
VVDVND + + I + ENS + I N+ G V I N
Sbjct: 337 TVVDVNDNAPEI---TITSSINSILENSPPGTV--IALLNVQDQDSGENGQVSCFIPNHL 391
Query: 725 DVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
+ + T + LDRE Y +T+ A ++G + V + + D+NDNP
Sbjct: 392 PFKLEKTYGNYYKLITSRVLDRELVQSYNITLTAT-DQGSPPLSAETHVWLNVADDNDNP 450
Query: 785 PVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFD 838
PVF H++Y +I EN+ G I + A D D NAL Y+L +
Sbjct: 451 PVFPHSSYSAYIPENNPRGASIFS---VTALDPDSKQNALVTYSLTDDTVQGVPLSSYVS 507
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
++ NTGV+ + S D E+ +L ++ARD+G LSS L + + D+NDN PE
Sbjct: 508 INSNTGVL-YALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPE 562
Score = 80.6 bits (190), Expect = 4e-14
Identities = 64/217 (29%), Positives = 97/217 (44%), Gaps = 20/217 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PENI GT ++ +NA D D G+NG++ Y F + + + A E+ F ++ + G
Sbjct: 252 VPENISSGTRVLMVNATDPDEGINGEVMYSFRN--------MESKASEI---FQLDSQTG 300
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
V V SL E + + I DGG L ++ + V DVND+ P T ++ E
Sbjct: 301 EVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILEN 360
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
V+ ++ D D G+N ++ FI LPF++ G L + LDRE
Sbjct: 361 SPPGTVIALLNVQDQDSGENGQVSCFI---PNHLPFKLEKTYGNYYKLITSRVLDRELVQ 417
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
Y +T+ A D G D NDN P F
Sbjct: 418 SYNITLTATDQGSPPLSAETHVWLNVADD-NDNPPVF 453
Score = 72.9 bits (171), Expect = 8e-12
Identities = 48/171 (28%), Positives = 84/171 (49%), Gaps = 7/171 (4%)
Query: 219 HAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQA 278
+A D D+GV + Y+L N L +G+ E L+ + +A +L + A
Sbjct: 157 NARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKEA-AHLLLLTA 215
Query: 279 SQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGEN 338
+P++ + + +LD+ND++P F Y +S+ EN+ +G VL V ATD D+G N
Sbjct: 216 LDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGIN 275
Query: 339 GEFTYQLDDPKG----AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
GE Y + + F +D ++G + VR LD E + M++ ++
Sbjct: 276 GEVMYSFRNMESKASEIFQLDSQTGEVQVRGS--LDFEKYRFYEMEIQGQD 324
Score = 68.1 bits (159), Expect = 2e-10
Identities = 61/204 (29%), Positives = 94/204 (46%), Gaps = 20/204 (9%)
Query: 954 NALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEF 1013
NA D D G+N Y+ + Y +L++ R ++ +++ SL E E
Sbjct: 157 NARDPDVGVNSLQSYQLSPNNYF--------SLQL-RGRTDGAKNPELVLEGSLDREKEA 207
Query: 1014 R--LNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVD 1068
L ++ALDGG+ + +RV V DVNDH P+F ++ Y +V E RVL V+
Sbjct: 208 AHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVL-MVN 266
Query: 1069 ATDADFGQNANLTYFIQPSDTDLP--FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
ATD D G N + Y + ++ F++ TG + V G LD E Y + + +D G
Sbjct: 267 ATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGG 326
Query: 1127 XXXXXXXXXXXXXXXXDVNDNSPK 1150
DVNDN+P+
Sbjct: 327 ---GLFTTTTMLITVVDVNDNAPE 347
Score = 61.7 bits (143), Expect = 2e-08
Identities = 68/269 (25%), Positives = 112/269 (41%), Gaps = 22/269 (8%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
V V+DVND + + + V EN + ++ N + G V + N
Sbjct: 231 VVVLDVNDHIPMFTQSVYR---VSVPENISSGT--RVLMVNATDPDEGINGEVMYSFRNM 285
Query: 724 QDVTDDI--AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
+ +I ++ G + + LD EK Y M + + G+ + + I + D N
Sbjct: 286 ESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTT---TMLITVVDVN 342
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDE 841
DN P + I+ENS GT I + N+ D D G N + F F +++
Sbjct: 343 DNAPEITITSSINSILENSPPGTVIALLNV---QDQDSGENG--QVSCFIPNHLPFKLEK 397
Query: 842 NTG-VVKFIGDS-LDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
G K I LDRE Y ++L A D G LS+E + + + D+NDN P F
Sbjct: 398 TYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSS 457
Query: 898 ENSKVRIHRETKLNGTAGFTIIEVKPKNK 926
++ + E G + F++ + P +K
Sbjct: 458 YSAYI---PENNPRGASIFSVTALDPDSK 483
Score = 60.9 bits (141), Expect = 3e-08
Identities = 70/240 (29%), Positives = 101/240 (42%), Gaps = 19/240 (7%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
+I V N A ++ + I EN P GT I LN D DSG NGQ+ + +
Sbjct: 335 LITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHL--- 391
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFV 1035
P KL + Y +I R ++ R L + + ++A D G+ L+ V + V
Sbjct: 392 PFKL--EKTYGNYYKLITSR----VLDREL--VQSYNITLTATDQGSPPLSAETHVWLNV 443
Query: 1036 KDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTD-LPF- 1093
D ND+ PVF + Y+ + E + V A D D QNA +TY + +P
Sbjct: 444 ADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLS 503
Query: 1094 ---EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
I+ TGVL D E L V+ARD+G D NDN+P+
Sbjct: 504 SYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSG-DPPLSSNVSLSLFVLDQNDNAPE 562
Score = 54.8 bits (126), Expect = 2e-06
Identities = 51/172 (29%), Positives = 76/172 (44%), Gaps = 19/172 (11%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P G +I + ALD DS N + Y + + + + Y IN G
Sbjct: 462 IPENNPRGASIFSVTALDPDSKQNALVTYSLTDD--------TVQGVPLSSYVSINSNTG 513
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK----KTWYN 1051
+ +S E + L + A D G+ L+ N+S+ +FV D ND+ P T +
Sbjct: 514 VLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGS 573
Query: 1052 FNVEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG 1100
VE A + ++ KV A D D GQNA L+Y + + F + TG
Sbjct: 574 TGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGEHTG 625
Score = 53.6 bits (123), Expect = 5e-06
Identities = 44/171 (25%), Positives = 79/171 (46%), Gaps = 11/171 (6%)
Query: 218 IHAIDQDLGVGATLRYEL--ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
++A D D G+ + Y + ++F LDS G + + LD + + + ++
Sbjct: 265 VNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFE-----KYRFYEME 319
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
+Q Q L T + I ++D+NDN PE + SI+EN P G + + D+D
Sbjct: 320 IQG-QDGGGLFTTTTML-ITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDS 377
Query: 336 GENGEFTYQLDDPKGAFSIDPRSG-WLTVRNQTVLDREAHSSLRMKVYAKE 385
GENG+ + + + F ++ G + + VLDRE S + + A +
Sbjct: 378 GENGQVSCFIPNHL-PFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATD 427
Score = 50.4 bits (115), Expect = 5e-05
Identities = 36/123 (29%), Positives = 58/123 (47%), Gaps = 9/123 (7%)
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
++ + + A+ +P +A+ V + + D NDN P F Y+ I EN P G S+ V A
Sbjct: 418 SYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTA 477
Query: 331 TDKDQGENGEFTYQLDD------PKGAF-SIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
D D +N TY L D P ++ SI+ +G L D E L ++V A
Sbjct: 478 LDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQS--FDYEQFRDLELRVIA 535
Query: 384 KET 386
+++
Sbjct: 536 RDS 538
Score = 47.6 bits (108), Expect = 3e-04
Identities = 41/141 (29%), Positives = 67/141 (47%), Gaps = 9/141 (6%)
Query: 221 IDQDLGVG----ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
I +DLG+ A ++S +LF+++ +GSL +D + ++ F L +
Sbjct: 49 ISKDLGLEPRELAKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCF-LNM 107
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+ + + LK VE+E++D+NDN P F+ D I + E+ G A D D G
Sbjct: 108 ELL-VEDTLKIYG--VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVG 164
Query: 337 ENGEFTYQLDDPKGAFSIDPR 357
N +YQL P FS+ R
Sbjct: 165 VNSLQSYQL-SPNNYFSLQLR 184
Score = 43.2 bits (97), Expect = 0.007
Identities = 46/171 (26%), Positives = 68/171 (39%), Gaps = 14/171 (8%)
Query: 992 FVINERHGHVIVARSLPPE------SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVF 1045
F +N R G +I A + E S LN+ L L V V + D+ND+ P F
Sbjct: 76 FAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKI-YGVEVEIIDINDNAPSF 134
Query: 1046 KKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG----- 1100
++ V E +A D D G N+ +Y + P++ ++ T
Sbjct: 135 QEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNY-FSLQLRGRTDGAKNP 193
Query: 1101 VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
L + G LDRE E ++L + A D G DVND+ P F
Sbjct: 194 ELVLEGSLDREKEAAHLLLLTALDGG-DPIRKGAVPIRVVVLDVNDHIPMF 243
Score = 40.7 bits (91), Expect = 0.039
Identities = 41/156 (26%), Positives = 71/156 (45%), Gaps = 19/156 (12%)
Query: 218 IHAIDQDLGVGATLRYEL----ISGNDRKLF-SLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A+D D A + Y L + G + S++S G L+ + D + +L+
Sbjct: 475 VTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLE---- 530
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLPN----GFSV 325
L+V A +P ++ + + +LD NDN PE + + VE P G+ V
Sbjct: 531 -LRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLV 589
Query: 326 LQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSG 359
+V+A DKD G+N +Y+L G F++ +G
Sbjct: 590 TKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGEHTG 625
Score = 37.5 bits (83), Expect = 0.37
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 11/90 (12%)
Query: 436 DEQLMSFVNVEVTLLDANDNNP-VFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPD 488
D L S V++ + +LD NDN P + P S E + +S A+ G ++ KV AVD D
Sbjct: 540 DPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRS-AEPGYLVTKVVAVDKD 598
Query: 489 LGQNGMVLYDLQRTSNLTITSPFKINPNTG 518
GQN + Y L + S + F + +TG
Sbjct: 599 SGQNAWLSYRLLKASEPGL---FAVGEHTG 625
Score = 35.1 bits (77), Expect = 2.0
Identities = 62/302 (20%), Positives = 111/302 (36%), Gaps = 25/302 (8%)
Query: 1093 FEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY 1152
F ++P +G L G +DRE + + + D+NDN+P F
Sbjct: 76 FAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPSFQ 135
Query: 1153 AFD-ELLEWKH--PEAD-ELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIG 1208
+ E+ +H P A L N V + + + N + TD
Sbjct: 136 EDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLR----GRTDGAK 191
Query: 1209 NGNGLILYSLPQRKNQQNL--------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISR 1260
N ++ SL + K +L G P + V V DV D + P+F
Sbjct: 192 NPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHI-----PMFTQS 246
Query: 1261 YYELEIEENVNAPVELVSLNLTEHYENFKMR-YYILNENDTDIRRTFVIDPRNGTLYLVR 1319
Y + + EN+++ ++ +N T+ E Y ++ F +D + G + +
Sbjct: 247 VYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRG 306
Query: 1320 SPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPK 1379
S D E YE+ ++ + M+ V DV + ++ + I + +NSP
Sbjct: 307 SLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVV-DVNDNAP--EITITSSINSILENSPP 363
Query: 1380 FT 1381
T
Sbjct: 364 GT 365
>AF152320-1|AAD43714.1| 935|Homo sapiens protocadherin gamma A11
protein.
Length = 935
Score = 127 bits (307), Expect = 3e-28
Identities = 126/476 (26%), Positives = 196/476 (41%), Gaps = 33/476 (6%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
N+E E + VEV ++D NDN P F + E + +A G A DPD+G
Sbjct: 106 NMELLVEDTLKIYGVEVEIIDINDNAPSFQEDEV-EIKVSEHAIPGARFALPNARDPDVG 164
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSE 547
N + Y L + ++ + + V E + E H L + A D +
Sbjct: 165 VNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRK 224
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QND 605
+ VV ++V IP F + Y V N+ GT V + D E +
Sbjct: 225 GAVPIRVVVLDVN-------DHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGE 277
Query: 606 VSYDLLHGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
V Y + + F ++ ++G + V L Y+ E + Q+ L T +
Sbjct: 278 VMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEME-IQGQDGGGLFTTTTMLI 336
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
VVDVND + + I + ENS + I N+ G V I N
Sbjct: 337 TVVDVNDNAPEI---TITSSINSILENSPPGTV--IALLNVQDQDSGENGQVSCFIPNHL 391
Query: 725 DVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
+ + T + LDRE Y +T+ A ++G + V + + D+NDNP
Sbjct: 392 PFKLEKTYGNYYKLITSRVLDRELVQSYNITLTAT-DQGSPPLSAETHVWLNVADDNDNP 450
Query: 785 PVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFD 838
PVF H++Y +I EN+ G I + A D D NAL Y+L +
Sbjct: 451 PVFPHSSYSAYIPENNPRGASIFS---VTALDPDSKQNALVTYSLTDDTVQGVPLSSYVS 507
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
++ NTGV+ + S D E+ +L ++ARD+G LSS L + + D+NDN PE
Sbjct: 508 INSNTGVL-YALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPE 562
Score = 80.6 bits (190), Expect = 4e-14
Identities = 64/217 (29%), Positives = 97/217 (44%), Gaps = 20/217 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PENI GT ++ +NA D D G+NG++ Y F + + + A E+ F ++ + G
Sbjct: 252 VPENISSGTRVLMVNATDPDEGINGEVMYSFRN--------MESKASEI---FQLDSQTG 300
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
V V SL E + + I DGG L ++ + V DVND+ P T ++ E
Sbjct: 301 EVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILEN 360
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
V+ ++ D D G+N ++ FI LPF++ G L + LDRE
Sbjct: 361 SPPGTVIALLNVQDQDSGENGQVSCFI---PNHLPFKLEKTYGNYYKLITSRVLDRELVQ 417
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
Y +T+ A D G D NDN P F
Sbjct: 418 SYNITLTATDQGSPPLSAETHVWLNVADD-NDNPPVF 453
Score = 72.9 bits (171), Expect = 8e-12
Identities = 48/171 (28%), Positives = 84/171 (49%), Gaps = 7/171 (4%)
Query: 219 HAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQA 278
+A D D+GV + Y+L N L +G+ E L+ + +A +L + A
Sbjct: 157 NARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKEA-AHLLLLTA 215
Query: 279 SQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGEN 338
+P++ + + +LD+ND++P F Y +S+ EN+ +G VL V ATD D+G N
Sbjct: 216 LDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGIN 275
Query: 339 GEFTYQLDDPKG----AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
GE Y + + F +D ++G + VR LD E + M++ ++
Sbjct: 276 GEVMYSFRNMESKASEIFQLDSQTGEVQVRGS--LDFEKYRFYEMEIQGQD 324
Score = 68.1 bits (159), Expect = 2e-10
Identities = 61/204 (29%), Positives = 94/204 (46%), Gaps = 20/204 (9%)
Query: 954 NALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEF 1013
NA D D G+N Y+ + Y +L++ R ++ +++ SL E E
Sbjct: 157 NARDPDVGVNSLQSYQLSPNNYF--------SLQL-RGRTDGAKNPELVLEGSLDREKEA 207
Query: 1014 R--LNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVD 1068
L ++ALDGG+ + +RV V DVNDH P+F ++ Y +V E RVL V+
Sbjct: 208 AHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVL-MVN 266
Query: 1069 ATDADFGQNANLTYFIQPSDTDLP--FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
ATD D G N + Y + ++ F++ TG + V G LD E Y + + +D G
Sbjct: 267 ATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGG 326
Query: 1127 XXXXXXXXXXXXXXXXDVNDNSPK 1150
DVNDN+P+
Sbjct: 327 ---GLFTTTTMLITVVDVNDNAPE 347
Score = 61.7 bits (143), Expect = 2e-08
Identities = 68/269 (25%), Positives = 112/269 (41%), Gaps = 22/269 (8%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
V V+DVND + + + V EN + ++ N + G V + N
Sbjct: 231 VVVLDVNDHIPMFTQSVYR---VSVPENISSGT--RVLMVNATDPDEGINGEVMYSFRNM 285
Query: 724 QDVTDDI--AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
+ +I ++ G + + LD EK Y M + + G+ + + I + D N
Sbjct: 286 ESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTT---TMLITVVDVN 342
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDE 841
DN P + I+ENS GT I + N+ D D G N + F F +++
Sbjct: 343 DNAPEITITSSINSILENSPPGTVIALLNV---QDQDSGENG--QVSCFIPNHLPFKLEK 397
Query: 842 NTG-VVKFIGDS-LDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
G K I LDRE Y ++L A D G LS+E + + + D+NDN P F
Sbjct: 398 TYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSS 457
Query: 898 ENSKVRIHRETKLNGTAGFTIIEVKPKNK 926
++ + E G + F++ + P +K
Sbjct: 458 YSAYI---PENNPRGASIFSVTALDPDSK 483
Score = 61.3 bits (142), Expect = 3e-08
Identities = 60/199 (30%), Positives = 89/199 (44%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P G +I + ALD DS N + Y + + + + Y IN G
Sbjct: 462 IPENNPRGASIFSVTALDPDSKQNALVTYSLTDD--------TVQGVPLSSYVSINSNTG 513
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK----KTWYN 1051
+ +S E + L + A D G+ L+ N+S+ +FV D ND+ P T +
Sbjct: 514 VLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGS 573
Query: 1052 FNVEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG-VLSVNGE 1107
VE A + ++ KV A D D GQNA L+Y + + F + TG V +
Sbjct: 574 TGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARAL 633
Query: 1108 LDRETEDKYILTVVARDNG 1126
LDR+ K L V +D+G
Sbjct: 634 LDRDAL-KQSLVVAVQDHG 651
Score = 60.9 bits (141), Expect = 3e-08
Identities = 70/240 (29%), Positives = 101/240 (42%), Gaps = 19/240 (7%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
+I V N A ++ + I EN P GT I LN D DSG NGQ+ + +
Sbjct: 335 LITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHL--- 391
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFV 1035
P KL + Y +I R ++ R L + + ++A D G+ L+ V + V
Sbjct: 392 PFKL--EKTYGNYYKLITSR----VLDREL--VQSYNITLTATDQGSPPLSAETHVWLNV 443
Query: 1036 KDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTD-LPF- 1093
D ND+ PVF + Y+ + E + V A D D QNA +TY + +P
Sbjct: 444 ADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLS 503
Query: 1094 ---EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
I+ TGVL D E L V+ARD+G D NDN+P+
Sbjct: 504 SYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSG-DPPLSSNVSLSLFVLDQNDNAPE 562
Score = 53.6 bits (123), Expect = 5e-06
Identities = 44/171 (25%), Positives = 79/171 (46%), Gaps = 11/171 (6%)
Query: 218 IHAIDQDLGVGATLRYEL--ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
++A D D G+ + Y + ++F LDS G + + LD + + + ++
Sbjct: 265 VNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFE-----KYRFYEME 319
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
+Q Q L T + I ++D+NDN PE + SI+EN P G + + D+D
Sbjct: 320 IQG-QDGGGLFTTTTML-ITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDS 377
Query: 336 GENGEFTYQLDDPKGAFSIDPRSG-WLTVRNQTVLDREAHSSLRMKVYAKE 385
GENG+ + + + F ++ G + + VLDRE S + + A +
Sbjct: 378 GENGQVSCFIPNHL-PFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATD 427
Score = 50.4 bits (115), Expect = 5e-05
Identities = 36/123 (29%), Positives = 58/123 (47%), Gaps = 9/123 (7%)
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
++ + + A+ +P +A+ V + + D NDN P F Y+ I EN P G S+ V A
Sbjct: 418 SYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTA 477
Query: 331 TDKDQGENGEFTYQLDD------PKGAF-SIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
D D +N TY L D P ++ SI+ +G L D E L ++V A
Sbjct: 478 LDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQS--FDYEQFRDLELRVIA 535
Query: 384 KET 386
+++
Sbjct: 536 RDS 538
Score = 47.6 bits (108), Expect = 3e-04
Identities = 41/141 (29%), Positives = 67/141 (47%), Gaps = 9/141 (6%)
Query: 221 IDQDLGVG----ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
I +DLG+ A ++S +LF+++ +GSL +D + ++ F L +
Sbjct: 49 ISKDLGLEPRELAKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCF-LNM 107
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+ + + LK VE+E++D+NDN P F+ D I + E+ G A D D G
Sbjct: 108 ELL-VEDTLKIYG--VEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVG 164
Query: 337 ENGEFTYQLDDPKGAFSIDPR 357
N +YQL P FS+ R
Sbjct: 165 VNSLQSYQL-SPNNYFSLQLR 184
Score = 44.0 bits (99), Expect = 0.004
Identities = 45/170 (26%), Positives = 79/170 (46%), Gaps = 20/170 (11%)
Query: 218 IHAIDQDLGVGATLRYEL----ISGNDRKLF-SLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A+D D A + Y L + G + S++S G L+ + D + +L+
Sbjct: 475 VTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLE---- 530
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLPN----GFSV 325
L+V A +P ++ + + +LD NDN PE + + VE P G+ V
Sbjct: 531 -LRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLV 589
Query: 326 LQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREA 373
+V+A DKD G+N +Y+L G F++ +G + + +LDR+A
Sbjct: 590 TKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTA-RALLDRDA 638
Score = 43.2 bits (97), Expect = 0.007
Identities = 46/171 (26%), Positives = 68/171 (39%), Gaps = 14/171 (8%)
Query: 992 FVINERHGHVIVARSLPPE------SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVF 1045
F +N R G +I A + E S LN+ L L V V + D+ND+ P F
Sbjct: 76 FAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKI-YGVEVEIIDINDNAPSF 134
Query: 1046 KKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG----- 1100
++ V E +A D D G N+ +Y + P++ ++ T
Sbjct: 135 QEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNY-FSLQLRGRTDGAKNP 193
Query: 1101 VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
L + G LDRE E ++L + A D G DVND+ P F
Sbjct: 194 ELVLEGSLDREKEAAHLLLLTALDGG-DPIRKGAVPIRVVVLDVNDHIPMF 243
Score = 41.5 bits (93), Expect = 0.022
Identities = 39/132 (29%), Positives = 60/132 (45%), Gaps = 13/132 (9%)
Query: 436 DEQLMSFVNVEVTLLDANDNNP-VFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPD 488
D L S V++ + +LD NDN P + P S E + +S A+ G ++ KV AVD D
Sbjct: 540 DPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRS-AEPGYLVTKVVAVDKD 598
Query: 489 LGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPS 546
GQN + Y L + S + F + +TG V A + + + +L V D P
Sbjct: 599 SGQNAWLSYRLLKASEPGL---FAVGEHTGEVRTARALLDRDALKQSLVVAVQDHGQPPL 655
Query: 547 ERRYSLAVVTIE 558
+L V +
Sbjct: 656 SATVTLTVAVAD 667
Score = 35.1 bits (77), Expect = 2.0
Identities = 62/302 (20%), Positives = 111/302 (36%), Gaps = 25/302 (8%)
Query: 1093 FEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY 1152
F ++P +G L G +DRE + + + D+NDN+P F
Sbjct: 76 FAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPSFQ 135
Query: 1153 AFD-ELLEWKH--PEAD-ELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIG 1208
+ E+ +H P A L N V + + + N + TD
Sbjct: 136 EDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLR----GRTDGAK 191
Query: 1209 NGNGLILYSLPQRKNQQNL--------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISR 1260
N ++ SL + K +L G P + V V DV D + P+F
Sbjct: 192 NPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHI-----PMFTQS 246
Query: 1261 YYELEIEENVNAPVELVSLNLTEHYENFKMR-YYILNENDTDIRRTFVIDPRNGTLYLVR 1319
Y + + EN+++ ++ +N T+ E Y ++ F +D + G + +
Sbjct: 247 VYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRG 306
Query: 1320 SPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPK 1379
S D E YE+ ++ + M+ V DV + ++ + I + +NSP
Sbjct: 307 SLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVV-DVNDNAP--EITITSSINSILENSPP 363
Query: 1380 FT 1381
T
Sbjct: 364 GT 365
>BC013609-1|AAH13609.1| 796|Homo sapiens cadherin 11, type 2,
OB-cadherin (osteoblast) protein.
Length = 796
Score = 126 bits (305), Expect = 5e-28
Identities = 123/465 (26%), Positives = 204/465 (43%), Gaps = 45/465 (9%)
Query: 711 NGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGI 770
+G GN++++++ + T + + G I K LDRE+R Y + A
Sbjct: 83 SGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPP 142
Query: 771 YQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF 830
+ + ++D NDNPP F H TY + E S +GT + A D G +A +Y++
Sbjct: 143 SEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSIL 202
Query: 831 GEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARD----TGGLSSEAELIIMIGDE 886
EG+ F V+ TG+++ ++DRE K Y + + A+D GGLS +++I + D
Sbjct: 203 -EGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVMITLTDV 261
Query: 887 NDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPI 946
NDN P+F Q V E + G + VK K+ D+ + G
Sbjct: 262 NDNPPKFPQSVYQMSV---SEAAVPGE---EVGRVKAKDP---DIGENG----------- 301
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
++ N +D D + +I ++ ++ + K D E KR + + + A +
Sbjct: 302 ---LVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVD-FETKRAYSLK------VEAAN 351
Query: 1007 LPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGK 1066
+ + +F + G D ++V++ V+D D P+F Y V+E V+G+
Sbjct: 352 VHIDPKF------ISNGPFKDTVTVKIAVEDA-DEPPMFLAPSYIHEVQENAAAGTVVGR 404
Query: 1067 VDATDADFGQNANLTYFI-QPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
V A D D N+ + Y I + +D D F I+P G + LDRE +TV A +
Sbjct: 405 VHAKDPD-AANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEI 463
Query: 1126 GXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSN 1170
DVNDN+PKF A E + + LSN
Sbjct: 464 -HNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSN 507
Score = 89.4 bits (212), Expect = 9e-17
Identities = 83/287 (28%), Positives = 131/287 (45%), Gaps = 22/287 (7%)
Query: 592 VGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQ 651
VG++ + ++ Y +L G G F ++++SG I L R R Y A A+
Sbjct: 74 VGRLHSDIDSGDGNIKY-ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVD 132
Query: 652 ENAN--LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENS-AGAAIGQIFHTNMSS- 707
+ N L + V V D+ND L H +V E S G ++ Q+ ++
Sbjct: 133 RDTNRPLEPPSEFIVKVQDINDNPPEFL---HETYHANVPERSNVGTSVIQVTASDADDP 189
Query: 708 IYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKP-LDREKRDVYRMTVIAEFNKGVIS 766
YGN V ++ Q + + A+ G I T P +DRE ++ Y + + A+ G +
Sbjct: 190 TYGNSAKLVYSILEGQPYFSVE---AQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMG 246
Query: 767 G-AGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALF 825
G +G +V I + D NDNPP F + Y+ + E + G E+ +KA D D G N L
Sbjct: 247 GLSGTTKVMITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEV---GRVKAKDPDIGENGLV 303
Query: 826 MYTLF-GEGKEMF----DVDENTGVVKFIGDSLDREKKIMYKLSLVA 867
Y + G+G E F D + GV+K + +D E K Y L + A
Sbjct: 304 TYNIVDGDGMESFEITTDYETQEGVIK-LKKPVDFETKRAYSLKVEA 349
Score = 77.4 bits (182), Expect = 4e-13
Identities = 111/437 (25%), Positives = 181/437 (41%), Gaps = 57/437 (13%)
Query: 992 FVINERHGHVIVARSLPPE--SEFRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFK 1046
FVI+++ G++ ++L E +++ L A+D L V V+D+ND+ P F
Sbjct: 101 FVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFL 160
Query: 1047 KTWYNFNVEEAQYTRRVLGKVDATDAD---FGQNANLTYFIQPSDTDLPFEISPLTGVL- 1102
Y+ NV E + +V A+DAD +G +A L Y I F + TG++
Sbjct: 161 HETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPY--FSVEAQTGIIR 218
Query: 1103 SVNGELDRETEDKYILTVVARD-NGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWK 1161
+ +DRE +++Y + + A+D G DVNDN PKF + +
Sbjct: 219 TALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVMITLTDVNDNPPKFP--QSVYQMS 276
Query: 1162 HPEADELSNHNFESVMMIPVYKATIEENAPIGTTVA-----KVFANDTDFIGNGNGLILY 1216
EA E V + I EN + + + F TD+ G+I
Sbjct: 277 VSEAAVPG----EEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDY-ETQEGVIKL 331
Query: 1217 SLP---QRKNQQNLGL--------PSLSSTAILMVTVADVPDEVEMSDKP-VFISRYYEL 1264
P + K +L + P S TV V VE +D+P +F++ Y
Sbjct: 332 KKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVT-VKIAVEDADEPPMFLAPSYIH 390
Query: 1265 EIEENVNAPVELVSLNLTE-HYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDR 1323
E++EN A + ++ + N +RY I + TD+ R F I+P +G + + DR
Sbjct: 391 EVQENAAAGTVVGRVHAKDPDAANSPIRYSI--DRHTDLDRFFTINPEDGFIKTTKPLDR 448
Query: 1324 EVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNG 1383
E + V ++ E+ H + A+ V V +R+ DVNDN+PKF
Sbjct: 449 EETAWLNITV------FAAEI-HNRHQEAK----------VPVAIRVLDVNDNAPKFAAP 491
Query: 1384 NRPLVTAIPTTAPFGYQ 1400
+ T P Q
Sbjct: 492 YEGFICESDQTKPLSNQ 508
Score = 77.0 bits (181), Expect = 5e-13
Identities = 63/240 (26%), Positives = 102/240 (42%), Gaps = 11/240 (4%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L V +TL D NDN P F P ++Y+ S+ A G +G+VKA DPD+G+NG+V Y+
Sbjct: 248 LSGTTKVMITLTDVNDNPPKF-PQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYN 306
Query: 499 L---QRTSNLTITSPFKINPNTGTVSVAESPILEGRHA--LFVEASDQPANPSERRYSLA 553
+ + IT+ ++ G + + + E + A L VEA++ +P
Sbjct: 307 IVDGDGMESFEITTDYE--TQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPF 364
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND-VSYDLLH 612
T+ V + + + P F+ Y V N GT VG++ D N + Y +
Sbjct: 365 KDTVTVKIAVE-DADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDR 423
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTNATVHVVDVND 671
+ F + G I L R + A + N + + V+DVND
Sbjct: 424 HTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVND 483
Score = 74.5 bits (175), Expect = 3e-12
Identities = 116/455 (25%), Positives = 191/455 (41%), Gaps = 53/455 (11%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVD---PDLGQNGMVLYDLQRTS 503
V + D NDN P F+ Y ++ + VGT + +V A D P G + ++Y +
Sbjct: 147 VKVQDINDNPPEFLHET-YHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSI---- 201
Query: 504 NLTITSPFKINPNTGTVSVA----ESPILEGRHALFVEASDQPANPSERRYSLAVVTIEV 559
L F + TG + A + E H + ++A D + + V+ +
Sbjct: 202 -LEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVV-IQAKDMGGHMGGLSGTTKVM---I 256
Query: 560 TRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAF--EQNDVSYDLLHGYEEG 617
T + P P F + Y+ V G VG+++ D E V+Y+++ G +G
Sbjct: 257 TLTDVNDNP--PKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDG--DG 312
Query: 618 VP-FAV----EERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNA------TVHV 666
+ F + E + GVI + + + Y + A + + ++N TV +
Sbjct: 313 MESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKI 372
Query: 667 -VDVNDERGVLLKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
V+ DE + L ++ I V+EN+A G +G++ + + +R+ I
Sbjct: 373 AVEDADEPPMFLAPSY---IHEVQENAAAGTVVGRVHAKDPDA----ANSPIRYSIDRHT 425
Query: 725 DVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDN 783
D+ I EDG I T KPLDRE+ +TV A A + V I + D NDN
Sbjct: 426 DLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKV-PVAIRVLDVNDN 484
Query: 784 PPVFEHATYEGFIMENSKIGTEIKMDNI-IKATDADEGTNA-LFMYTLFGE-----GKEM 836
P F A YEGFI E+ + + I A D D+ N F+++L E +
Sbjct: 485 APKFA-APYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPNFTV 543
Query: 837 FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG 871
D +NT V R+K+ +Y L +V D G
Sbjct: 544 RDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGG 578
Score = 62.5 bits (145), Expect = 1e-08
Identities = 47/167 (28%), Positives = 81/167 (48%), Gaps = 9/167 (5%)
Query: 222 DQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQL 281
D D G G ++Y L +F +D +G++ K LD E Q T + Q
Sbjct: 80 DIDSGDG-NIKYILSGEGAGTIFVIDDKSGNIHATKTLD--REERAQY-TLMAQAVDRDT 135
Query: 282 NNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ---GEN 338
N PL+ + +++ D+NDN PEF + Y+ ++ E G SV+QV A+D D G +
Sbjct: 136 NRPLEPPSEFI-VKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNS 194
Query: 339 GEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ Y + + + FS++ ++G + +DREA + + AK+
Sbjct: 195 AKLVYSILEGQPYFSVEAQTGIIRTALPN-MDREAKEEYHVVIQAKD 240
Score = 52.8 bits (121), Expect = 9e-06
Identities = 47/171 (27%), Positives = 79/171 (46%), Gaps = 14/171 (8%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLE-KELDLDAEHNLQANTFVLQVQA 278
A D G A L Y ++ G + FS+++ G + +D +A+ + + +QA
Sbjct: 186 ADDPTYGNSAKLVYSILEG--QPYFSVEAQTGIIRTALPNMDREAKEE-----YHVVIQA 238
Query: 279 SQLNNPLK--TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+ + + +V I L D+NDN P+F Y +S+ E G V +V A D D G
Sbjct: 239 KDMGGHMGGLSGTTKVMITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIG 298
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLT----VRNQTVLDREAHSSLRMKVYA 383
ENG TY + D G S + + + T ++ + +D E + +KV A
Sbjct: 299 ENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEA 349
Score = 48.0 bits (109), Expect = 3e-04
Identities = 55/221 (24%), Positives = 88/221 (39%), Gaps = 33/221 (14%)
Query: 926 KFALDVDQLGPLFLIP-------ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
K A++ P+FL P EN GT + +++A D D+ N IRY +
Sbjct: 371 KIAVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAA-NSPIRYSIDRHT---- 425
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISA----LDGGNLNDNISVRVF 1034
++ R+F IN G + + L E LNI+ + + + V +
Sbjct: 426 --------DLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIR 477
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQ---YTRRVLGKVDATDADFGQNANLTYFIQPSDT-- 1089
V DVND+ P F + F E Q + + + + A D D N F P +
Sbjct: 478 VLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIH 537
Query: 1090 DLPFEISP----LTGVLSVNGELDRETEDKYILTVVARDNG 1126
+ F + GV + G R+ +D Y+L +V D G
Sbjct: 538 NPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGG 578
Score = 45.6 bits (103), Expect = 0.001
Identities = 36/133 (27%), Positives = 63/133 (47%), Gaps = 11/133 (8%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR-KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+HA D D + +RY + D + F+++ +G F++ LD E N + V
Sbjct: 405 VHAKDPD-AANSPIRYSIDRHTDLDRFFTINPEDG--FIKTTKPLDREETAWLN---ITV 458
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFS---VLQVMATDK 333
A++++N + A+ V I +LD+NDN P+F + + S ++ + A DK
Sbjct: 459 FAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDK 518
Query: 334 DQGENG-EFTYQL 345
D NG F + L
Sbjct: 519 DDTANGPRFIFSL 531
Score = 36.7 bits (81), Expect = 0.64
Identities = 27/114 (23%), Positives = 54/114 (47%), Gaps = 18/114 (15%)
Query: 1306 FVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVK 1365
FVID ++G ++ ++ DRE + Y ++ +A + +R L P +E
Sbjct: 101 FVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLE----PPSE------------ 144
Query: 1366 VVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQLKGAIGHHPTASRTVR 1419
+V+++D+NDN P+F + +P + G V+Q+ + PT + +
Sbjct: 145 FIVKVQDINDNPPEFL--HETYHANVPERSNVGTSVIQVTASDADDPTYGNSAK 196
>AB209760-1|BAD92997.1| 798|Homo sapiens cadherin 11, type 2 isoform
1 preproprotein variant protein.
Length = 798
Score = 126 bits (303), Expect = 8e-28
Identities = 123/465 (26%), Positives = 203/465 (43%), Gaps = 45/465 (9%)
Query: 711 NGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGI 770
+G GN++++++ + T + + G I K LDRE+R Y + A
Sbjct: 85 SGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPP 144
Query: 771 YQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF 830
+ + ++D NDNPP F H TY + E S +GT + A D G +A +Y++
Sbjct: 145 SEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSIL 204
Query: 831 GEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARD----TGGLSSEAELIIMIGDE 886
EG+ F V+ TG+++ ++DRE K Y + + A+D GGLS ++ I + D
Sbjct: 205 -EGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDV 263
Query: 887 NDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPI 946
NDN P+F Q V E + G + VK K+ D+ + G
Sbjct: 264 NDNPPKFPQSVYQMSV---SEAAVPGE---EVGRVKAKDP---DIGENG----------- 303
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
++ N +D D + +I ++ ++ + K D E KR + + + A +
Sbjct: 304 ---LVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVD-FETKRAYSLK------VEAAN 353
Query: 1007 LPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGK 1066
+ + +F + G D ++V++ V+D D P+F Y V+E V+G+
Sbjct: 354 VHIDPKF------ISNGPFKDTVTVKIAVEDA-DEPPMFLAPSYIHEVQENAAAGTVVGR 406
Query: 1067 VDATDADFGQNANLTYFI-QPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
V A D D N+ + Y I + +D D F I+P G + LDRE +TV A +
Sbjct: 407 VHAKDPD-AANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEI 465
Query: 1126 GXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSN 1170
DVNDN+PKF A E + + LSN
Sbjct: 466 -HNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSN 509
Score = 91.9 bits (218), Expect = 2e-17
Identities = 84/287 (29%), Positives = 132/287 (45%), Gaps = 22/287 (7%)
Query: 592 VGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQ 651
VG++ + ++ Y +L G G F ++++SG I L R R Y A A+
Sbjct: 76 VGRLHSDIDSGDGNIKY-ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVD 134
Query: 652 ENAN--LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENS-AGAAIGQIFHTNMSS- 707
+ N L + V V D+ND L H +V E S G ++ Q+ ++
Sbjct: 135 RDTNRPLEPPSEFIVKVQDINDNPPEFL---HETYHANVPERSNVGTSVIQVTASDADDP 191
Query: 708 IYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKP-LDREKRDVYRMTVIAEFNKGVIS 766
YGN V ++ Q + + A+ G I T P +DRE ++ Y + + A+ G +
Sbjct: 192 TYGNSAKLVYSILEGQPYFSVE---AQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMG 248
Query: 767 G-AGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALF 825
G +G +VTI + D NDNPP F + Y+ + E + G E+ +KA D D G N L
Sbjct: 249 GLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEV---GRVKAKDPDIGENGLV 305
Query: 826 MYTLF-GEGKEMF----DVDENTGVVKFIGDSLDREKKIMYKLSLVA 867
Y + G+G E F D + GV+K + +D E K Y L + A
Sbjct: 306 TYNIVDGDGMESFEITTDYETQEGVIK-LKKPVDFETKRAYSLKVEA 351
Score = 77.8 bits (183), Expect = 3e-13
Identities = 111/437 (25%), Positives = 181/437 (41%), Gaps = 57/437 (13%)
Query: 992 FVINERHGHVIVARSLPPE--SEFRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFK 1046
FVI+++ G++ ++L E +++ L A+D L V V+D+ND+ P F
Sbjct: 103 FVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFL 162
Query: 1047 KTWYNFNVEEAQYTRRVLGKVDATDAD---FGQNANLTYFIQPSDTDLPFEISPLTGVL- 1102
Y+ NV E + +V A+DAD +G +A L Y I F + TG++
Sbjct: 163 HETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPY--FSVEAQTGIIR 220
Query: 1103 SVNGELDRETEDKYILTVVARD-NGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWK 1161
+ +DRE +++Y + + A+D G DVNDN PKF + +
Sbjct: 221 TALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFP--QSVYQMS 278
Query: 1162 HPEADELSNHNFESVMMIPVYKATIEENAPIGTTVA-----KVFANDTDFIGNGNGLILY 1216
EA E V + I EN + + + F TD+ G+I
Sbjct: 279 VSEAAVPG----EEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDY-ETQEGVIKL 333
Query: 1217 SLP---QRKNQQNLGL--------PSLSSTAILMVTVADVPDEVEMSDKP-VFISRYYEL 1264
P + K +L + P S TV V VE +D+P +F++ Y
Sbjct: 334 KKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVT-VKIAVEDADEPPMFLAPSYIH 392
Query: 1265 EIEENVNAPVELVSLNLTE-HYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDR 1323
E++EN A + ++ + N +RY I + TD+ R F I+P +G + + DR
Sbjct: 393 EVQENAAAGTVVGRVHAKDPDAANSPIRYSI--DRHTDLDRFFTINPEDGFIKTTKPLDR 450
Query: 1324 EVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNG 1383
E + V ++ E+ H + A+ V V +R+ DVNDN+PKF
Sbjct: 451 EETAWLNITV------FAAEI-HNRHQEAK----------VPVAIRVLDVNDNAPKFAAP 493
Query: 1384 NRPLVTAIPTTAPFGYQ 1400
+ T P Q
Sbjct: 494 YEGFICESDQTKPLSNQ 510
Score = 77.4 bits (182), Expect = 4e-13
Identities = 63/240 (26%), Positives = 102/240 (42%), Gaps = 11/240 (4%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L V +TL D NDN P F P ++Y+ S+ A G +G+VKA DPD+G+NG+V Y+
Sbjct: 250 LSGTTKVTITLTDVNDNPPKF-PQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYN 308
Query: 499 L---QRTSNLTITSPFKINPNTGTVSVAESPILEGRHA--LFVEASDQPANPSERRYSLA 553
+ + IT+ ++ G + + + E + A L VEA++ +P
Sbjct: 309 IVDGDGMESFEITTDYE--TQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPF 366
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND-VSYDLLH 612
T+ V + + + P F+ Y V N GT VG++ D N + Y +
Sbjct: 367 KDTVTVKIAVE-DADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDR 425
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTNATVHVVDVND 671
+ F + G I L R + A + N + + V+DVND
Sbjct: 426 HTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVND 485
Score = 76.2 bits (179), Expect = 9e-13
Identities = 118/455 (25%), Positives = 190/455 (41%), Gaps = 53/455 (11%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVD---PDLGQNGMVLYDLQRTS 503
V + D NDN P F+ Y ++ + VGT + +V A D P G + ++Y +
Sbjct: 149 VKVQDINDNPPEFLHET-YHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSI---- 203
Query: 504 NLTITSPFKINPNTGTVSVA----ESPILEGRHALFVEASDQPANPSERRYSLAVVTIEV 559
L F + TG + A + E H + ++A D + VTI +
Sbjct: 204 -LEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVV-IQAKDMGGHMGGLS-GTTKVTITL 260
Query: 560 TRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAF--EQNDVSYDLLHGYEEG 617
T N P P + Y+ V G VG+++ D E V+Y+++ G +G
Sbjct: 261 T-DVNDNPPKFPQSV---YQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDG--DG 314
Query: 618 VP-FAV----EERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNA------TVHV 666
+ F + E + GVI + + + Y + A + + ++N TV +
Sbjct: 315 MESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKI 374
Query: 667 -VDVNDERGVLLKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
V+ DE + L ++ I V+EN+A G +G++ + + +R+ I
Sbjct: 375 AVEDADEPPMFLAPSY---IHEVQENAAAGTVVGRVHAKDPDA----ANSPIRYSIDRHT 427
Query: 725 DVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDN 783
D+ I EDG I T KPLDRE+ +TV A A + V I + D NDN
Sbjct: 428 DLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKV-PVAIRVLDVNDN 486
Query: 784 PPVFEHATYEGFIMENSKIGTEIKMDNI-IKATDADEGTNA-LFMYTLFGE-----GKEM 836
P F A YEGFI E+ + + I A D D+ N F+++L E +
Sbjct: 487 APKFA-APYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPNFTV 545
Query: 837 FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG 871
D +NT V R+K+ +Y L +V D G
Sbjct: 546 RDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGG 580
Score = 62.5 bits (145), Expect = 1e-08
Identities = 47/167 (28%), Positives = 81/167 (48%), Gaps = 9/167 (5%)
Query: 222 DQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQL 281
D D G G ++Y L +F +D +G++ K LD E Q T + Q
Sbjct: 82 DIDSGDG-NIKYILSGEGAGTIFVIDDKSGNIHATKTLD--REERAQY-TLMAQAVDRDT 137
Query: 282 NNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ---GEN 338
N PL+ + +++ D+NDN PEF + Y+ ++ E G SV+QV A+D D G +
Sbjct: 138 NRPLEPPSEFI-VKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNS 196
Query: 339 GEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ Y + + + FS++ ++G + +DREA + + AK+
Sbjct: 197 AKLVYSILEGQPYFSVEAQTGIIRTALPN-MDREAKEEYHVVIQAKD 242
Score = 53.2 bits (122), Expect = 7e-06
Identities = 47/171 (27%), Positives = 79/171 (46%), Gaps = 14/171 (8%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLE-KELDLDAEHNLQANTFVLQVQA 278
A D G A L Y ++ G + FS+++ G + +D +A+ + + +QA
Sbjct: 188 ADDPTYGNSAKLVYSILEG--QPYFSVEAQTGIIRTALPNMDREAKEE-----YHVVIQA 240
Query: 279 SQLNNPLK--TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+ + + +V I L D+NDN P+F Y +S+ E G V +V A D D G
Sbjct: 241 KDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIG 300
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLT----VRNQTVLDREAHSSLRMKVYA 383
ENG TY + D G S + + + T ++ + +D E + +KV A
Sbjct: 301 ENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEA 351
Score = 48.0 bits (109), Expect = 3e-04
Identities = 55/221 (24%), Positives = 88/221 (39%), Gaps = 33/221 (14%)
Query: 926 KFALDVDQLGPLFLIP-------ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
K A++ P+FL P EN GT + +++A D D+ N IRY +
Sbjct: 373 KIAVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAA-NSPIRYSIDRHT---- 427
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISA----LDGGNLNDNISVRVF 1034
++ R+F IN G + + L E LNI+ + + + V +
Sbjct: 428 --------DLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIR 479
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQ---YTRRVLGKVDATDADFGQNANLTYFIQPSDT-- 1089
V DVND+ P F + F E Q + + + + A D D N F P +
Sbjct: 480 VLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIH 539
Query: 1090 DLPFEISP----LTGVLSVNGELDRETEDKYILTVVARDNG 1126
+ F + GV + G R+ +D Y+L +V D G
Sbjct: 540 NPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGG 580
Score = 45.6 bits (103), Expect = 0.001
Identities = 36/133 (27%), Positives = 63/133 (47%), Gaps = 11/133 (8%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR-KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+HA D D + +RY + D + F+++ +G F++ LD E N + V
Sbjct: 407 VHAKDPD-AANSPIRYSIDRHTDLDRFFTINPEDG--FIKTTKPLDREETAWLN---ITV 460
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFS---VLQVMATDK 333
A++++N + A+ V I +LD+NDN P+F + + S ++ + A DK
Sbjct: 461 FAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDK 520
Query: 334 DQGENG-EFTYQL 345
D NG F + L
Sbjct: 521 DDTANGPRFIFSL 533
Score = 36.7 bits (81), Expect = 0.64
Identities = 27/114 (23%), Positives = 54/114 (47%), Gaps = 18/114 (15%)
Query: 1306 FVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVK 1365
FVID ++G ++ ++ DRE + Y ++ +A + +R L P +E
Sbjct: 103 FVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLE----PPSE------------ 146
Query: 1366 VVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQLKGAIGHHPTASRTVR 1419
+V+++D+NDN P+F + +P + G V+Q+ + PT + +
Sbjct: 147 FIVKVQDINDNPPEFL--HETYHANVPERSNVGTSVIQVTASDADDPTYGNSAK 198
Score = 35.1 bits (77), Expect = 2.0
Identities = 16/46 (34%), Positives = 25/46 (54%)
Query: 70 IGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEK 115
+G + +S VT+ + DVNDN P F + Y ++V E GE+
Sbjct: 243 MGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEE 288
>BC000059-1|AAH00059.2| 771|Homo sapiens CELSR1 protein protein.
Length = 771
Score = 125 bits (302), Expect = 1e-27
Identities = 130/471 (27%), Positives = 212/471 (45%), Gaps = 38/471 (8%)
Query: 430 ENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDL 489
E +++ + S +V +T+LD NDN+PVF YE + +A VG+ + ++A D D
Sbjct: 32 EAVDHGWPPMSSSTSVSITVLDVNDNDPVFTQPT-YELRLNEDAAVGSSVLTLQARDRDA 90
Query: 490 GQNGMVLYDLQRTSNLTITSPFKINPNTG----TVSVAESPILEGRHALFVEASDQPANP 545
N ++ Y L T T + F ++ G T+++ E ++ L V ASD
Sbjct: 91 --NSVITYQL--TGGNT-RNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT--- 142
Query: 546 SERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND 605
R A V I VT P F + Y V + +GTS+ + ND E
Sbjct: 143 ---RSHTAHVLINVTDANTHR----PVFQSSHYTVSVSEDRPVGTSIATLSAND--EDTG 193
Query: 606 VSYDLLHGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA--NLSIVTNA 662
+ + + ++ VP F ++ SG + + +L N+ Y +A Q+N S T
Sbjct: 194 ENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMA-QDNGIPQKSDTTTL 252
Query: 663 TVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIAN 722
+ ++D ND L + IF ++ +I Q+ T+ S G + +
Sbjct: 253 EILILDANDNAPQFLWDFYQGSIF--EDAPPSTSILQVSATDRDS---GPNGRLLYTFQG 307
Query: 723 QQDVTDDIAIAE-DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
D D I G I TQ+ LDRE VY + +A + ++ + I D N
Sbjct: 308 GDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDIN 367
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVD 840
DN P+FE E F+ EN+ +G+ + I+A D DEG NA MY + G+ + F +D
Sbjct: 368 DNAPMFEKDELELFVEENNPVGSVVAK---IRANDPDEGPNAQIMYQIVEGDMRHFFQLD 424
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKP 891
G ++ + + LD E + Y L +V + L S A + I++ D+NDN P
Sbjct: 425 LLNGDLRAMVE-LDFEVRREYVL-VVQATSAPLVSRATVHILLVDQNDNPP 473
Score = 119 bits (287), Expect = 7e-26
Identities = 167/626 (26%), Positives = 268/626 (42%), Gaps = 83/626 (13%)
Query: 510 PFKINPNTGTVSV-AESPILEGRHALF-VEASDQPANPSERRYSLAVVTIEVTRGTKGNK 567
PF+I+ ++G ++V AE E H F VEA D P S+++ ++V N
Sbjct: 3 PFQIHNSSGWITVCAELDREEVDHYSFGVEAVDHGWPPMSSSTSVSITVLDV------ND 56
Query: 568 PDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEER-- 625
D P F YE + + +G+SV ++ D + ++Y L G FA+ +
Sbjct: 57 ND-PVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRN-RFALSSQRG 114
Query: 626 SGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPII 685
G+IT+ L Y A + S + ++V D N R V + +H +
Sbjct: 115 GGLITLALPLDYKQEQQYVLAVTA--SDGTRSHTAHVLINVTDANTHRPVF-QSSHYTVS 171
Query: 686 FHVKENSAGAAIGQIFHTNMSSIYGNGTG-NVRFLIANQQDVTDDIAIAEDGTIFTQKPL 744
++ G +I + S TG N R Q V + GT++T L
Sbjct: 172 VS-EDRPVGTSIATL------SANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMEL 224
Query: 745 DREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGT 804
D E + Y +T++A+ N G+ + + I I D NDN P F Y+G I E++ T
Sbjct: 225 DYENQVAYTLTIMAQDN-GIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPST 283
Query: 805 EIKMDNIIKATDADEGTNALFMYTLFG--EGKEMFDVDENTGVVKFIGDSLDREKKIMYK 862
I + ATD D G N +YT G +G F ++ +GV++ LDRE +Y
Sbjct: 284 SILQ---VSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIR-TQRRLDRENVAVYN 339
Query: 863 LSLVARDTGG---LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTII 919
L +A D G LS+ E+ + I D NDN P F E ++ + E N G +
Sbjct: 340 LWALAVDRGSPTPLSASVEIQVTILDINDNAPMF----EKDELELFVEE--NNPVGSVVA 393
Query: 920 EVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPS 979
+++ A D D+ GP I I G + LDL LNG +R +
Sbjct: 394 KIR-----ANDPDE-GPNAQIMYQIVEG-DMRHFFQLDL---LNGDLR-----------A 432
Query: 980 KLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVN 1039
+ D EV+R +V+ V+ A S P S ++I +D NDN V
Sbjct: 433 MVELD-FEVRREYVL------VVQATSAPLVSRATVHILLVD---QNDNPPV-------- 474
Query: 1040 DHFPVFKKTWYNFNVEEA-QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPL 1098
P F+ + N+ ++ + V+G++ A D D + N T F+Q ++ L + P
Sbjct: 475 --LPDFQILFNNYVTNKSNSFPTGVIGRIPAHDPDVSDSLNYT-FVQGNELRL-LLLDPA 530
Query: 1099 TGVLSVNGELDRETEDKYILTVVARD 1124
TG L ++ +LD + ++ V D
Sbjct: 531 TGELQLSRDLDNNRPLEALMEVSVSD 556
Score = 98.3 bits (234), Expect = 2e-19
Identities = 116/437 (26%), Positives = 192/437 (43%), Gaps = 68/437 (15%)
Query: 929 LDVDQLGPLFLIP-------ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LDV+ P+F P E+ +G++++ L A D D+ N I Y+
Sbjct: 52 LDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA--NSVITYQLTGG-------- 101
Query: 982 SADALEVKRYFVINERHGHVIVARSLP----PESEFRLNISALDGGNLNDNISVRVFVKD 1037
+ F ++ + G ++ +LP E ++ L ++A DG + V + V D
Sbjct: 102 -----NTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR-SHTAHVLINVTD 155
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISP 1097
N H PVF+ + Y +V E + + + A D D G+NA +TY IQ D F I P
Sbjct: 156 ANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ--DPVPQFRIDP 213
Query: 1098 LTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDEL 1157
+G + ELD E + Y LT++A+DNG D NDN+P+F
Sbjct: 214 DSGTMYTMMELDYENQVAYTLTIMAQDNG-IPQKSDTTTLEILILDANDNAPQFL----- 267
Query: 1158 LEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDT---DF-IGNGNGL 1213
W + + S ++ V AT ++ P G + D DF I +G+
Sbjct: 268 --WDFYQGSIFEDAP-PSTSILQV-SATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGV 323
Query: 1214 ILYSLPQRKNQQNL------------GLPS-LSSTAILMVTVADVPDEVEMSDKPVFISR 1260
I +R +++N+ G P+ LS++ + VT+ D+ D + P+F
Sbjct: 324 I--RTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDIND-----NAPMFEKD 376
Query: 1261 YYELEIEEN--VNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLV 1318
EL +EEN V + V + N + N ++ Y I+ + D+R F +D NG L +
Sbjct: 377 ELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV---EGDMRHFFQLDLLNGDLRAM 433
Query: 1319 RSPDREVKDTYEVIVRA 1335
D EV+ Y ++V+A
Sbjct: 434 VELDFEVRREYVLVVQA 450
Score = 95.5 bits (227), Expect = 1e-18
Identities = 91/314 (28%), Positives = 136/314 (43%), Gaps = 31/314 (9%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPL 132
G +S+ SV++ + DVNDN P+F Y + ++E G + I
Sbjct: 37 GWPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITY 96
Query: 133 TVPRGLTIFKDIRAFDRDK-------PNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR 185
+ G T + + R P + Y + DG SH +L+
Sbjct: 97 QLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG----TRSHTAHVLIN 152
Query: 186 KVLDYDAGDKEFQ----LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDR 241
V D + FQ V ++ + + I + A D+D G A + Y + +
Sbjct: 153 -VTDANTHRPVFQSSHYTVSVSEDRPVGTSIA---TLSANDEDTGENARITY--VIQDPV 206
Query: 242 KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLND 301
F +D +G+++ ELD + N A T + Q + + P K+ +EI +LD ND
Sbjct: 207 PQFRIDPDSGTMYTMMELDYE---NQVAYTLTIMAQDNGI--PQKSDTTTLEILILDAND 261
Query: 302 NLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL---DDPKGAFSIDPRS 358
N P+F DFY SI E+ P S+LQV ATD+D G NG Y DD G F I+P S
Sbjct: 262 NAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTS 321
Query: 359 GWLTVRNQTVLDRE 372
G +R Q LDRE
Sbjct: 322 G--VIRTQRRLDRE 333
Score = 91.5 bits (217), Expect = 2e-17
Identities = 100/348 (28%), Positives = 152/348 (43%), Gaps = 58/348 (16%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ E+ P+GT+I L+A D D+G N +I Y V P ++ D+ G
Sbjct: 172 VSEDRPVGTSIATLSANDEDTGENARITYVIQDPV--PQFRIDPDS-------------G 216
Query: 1000 HVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNV- 1054
+ L E++ + L I A D G +D ++ + + D ND+ P F +Y ++
Sbjct: 217 TMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIF 276
Query: 1055 EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT-DLPFEISPLTGVLSVNGELDRETE 1113
E+A + +L +V ATD D G N L Y Q D D F I P +GV+ LDRE
Sbjct: 277 EDAPPSTSIL-QVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENV 335
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNF 1173
Y L +A D G D+NDN+P F E DEL
Sbjct: 336 AVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF------------EKDEL----- 378
Query: 1174 ESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLS 1233
+ +EEN P+G+ VAK+ AND D N I+Y + + + L L+
Sbjct: 379 ---------ELFVEENNPVGSVVAKIRANDPD--EGPNAQIMYQIVEGDMRHFFQLDLLN 427
Query: 1234 STAILMVTV-ADVPDE----VEMSDKPVFISR--YYELEIEENVNAPV 1274
MV + +V E V+ + P+ +SR + L +++N N PV
Sbjct: 428 GDLRAMVELDFEVRREYVLVVQATSAPL-VSRATVHILLVDQNDNPPV 474
Score = 83.8 bits (198), Expect = 4e-15
Identities = 53/163 (32%), Positives = 80/163 (49%), Gaps = 8/163 (4%)
Query: 223 QDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLN 282
+D + + Y+L GN R F+L S G + L LD + Q +VL V AS
Sbjct: 86 RDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQ---YVLAVTAS--- 139
Query: 283 NPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFT 342
+ ++ A V I + D N + P F+ Y +S+ E+ P G S+ + A D+D GEN T
Sbjct: 140 DGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARIT 199
Query: 343 YQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
Y + DP F IDP SG T+ LD E + + + A++
Sbjct: 200 YVIQDPVPQFRIDPDSG--TMYTMMELDYENQVAYTLTIMAQD 240
Score = 70.9 bits (166), Expect = 3e-11
Identities = 83/350 (23%), Positives = 148/350 (42%), Gaps = 30/350 (8%)
Query: 444 NVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTS 503
+V + + DAN + PVF S+ Y S+ + VGT I + A D D G+N + Y +Q
Sbjct: 148 HVLINVTDANTHRPVFQSSH-YTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDP- 205
Query: 504 NLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTR 561
F+I+P++GT+ E + + L + A D +L ++ ++
Sbjct: 206 ----VPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDAN- 260
Query: 562 GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLHGYEEGVP 619
+ P F+ Y+ + + TS+ Q+ D + + Y G +
Sbjct: 261 ------DNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGD 314
Query: 620 FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN--LSIVTNATVHVVDVNDERGVLL 677
F +E SGVI L R N +Y+ A+A+ + LS V ++D+ND +
Sbjct: 315 FYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFE 374
Query: 678 KGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDG 736
K +F + N G+ + +I + + + I + D+ + +G
Sbjct: 375 KDELE--LFVEENNPVGSVVAKIRANDPDE---GPNAQIMYQIV-EGDMRHFFQLDLLNG 428
Query: 737 TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
+ LD E R Y + V A + ++S A ++ I + D+NDNPPV
Sbjct: 429 DLRAMVELDFEVRREYVLVVQAT-SAPLVSRATVH---ILLVDQNDNPPV 474
Score = 66.5 bits (155), Expect = 7e-10
Identities = 50/169 (29%), Positives = 79/169 (46%), Gaps = 9/169 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKL-FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D+D G L Y G+D F ++ +G + ++ LD E+ N + L V
Sbjct: 288 VSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLD--RENVAVYNLWALAV 345
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
PL +A +++ +LD+NDN P FE D + + EN P G V ++ A D D+G
Sbjct: 346 DRGS-PTPL-SASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEG 403
Query: 337 ENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
N + YQ+ D + F +D +G +R LD E + V A
Sbjct: 404 PNAQIMYQIVEGDMRHFFQLDLLNG--DLRAMVELDFEVRREYVLVVQA 450
Score = 66.5 bits (155), Expect = 7e-10
Identities = 61/237 (25%), Positives = 108/237 (45%), Gaps = 17/237 (7%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L + V ++VT+LD NDN P+F L E ++ N VG+V+ K++A DPD G N ++Y
Sbjct: 353 LSASVEIQVTILDINDNAPMFEKDEL-ELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQ 411
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVT 556
+ + F+++ G + E R + L V+A+ P S A V
Sbjct: 412 IVEGD---MRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPL------VSRATVH 462
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSV-GQIRVNDAFEQNDVSYDLLHGYE 615
I + N P +PDF + + T V G+I +D + ++Y + G E
Sbjct: 463 ILLV-DQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGRIPAHDPDVSDSLNYTFVQGNE 521
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDE 672
+ ++ +G + + DL NRP+ V++ + + S+ T+ V + D+
Sbjct: 522 LRL-LLLDPATGELQLSRDLDN-NRPLEALMEVSVSDGIH-SVTAFCTLRVTIITDD 575
Score = 63.3 bits (147), Expect = 6e-09
Identities = 52/170 (30%), Positives = 82/170 (48%), Gaps = 16/170 (9%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I A D D G A + Y+++ G+ R F LD +NG L ELD + +VL VQ
Sbjct: 395 IRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRRE-----YVLVVQ 449
Query: 278 ASQLNNPLKTAQARVEIELLDLNDN---LPEFEVDFYNISIVENLPNGFS---VLQVMAT 331
A+ PL ++A V I L+D NDN LP+F++ F N V N N F + ++ A
Sbjct: 450 ATSA--PL-VSRATVHILLVDQNDNPPVLPDFQILFNN--YVTNKSNSFPTGVIGRIPAH 504
Query: 332 DKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKV 381
D D ++ +T+ + +DP +G L + +R + + + V
Sbjct: 505 DPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSV 554
Score = 56.8 bits (131), Expect = 6e-07
Identities = 70/256 (27%), Positives = 105/256 (41%), Gaps = 26/256 (10%)
Query: 1090 DLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
D PF+I +G ++V ELDRE D Y V A D+G DVNDN P
Sbjct: 1 DFPFQIHNSSGWITVCAELDREEVDHYSFGVEAVDHG-WPPMSSSTSVSITVLDVNDNDP 59
Query: 1150 KFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGN 1209
F E + E + + + I G T + FA +
Sbjct: 60 VF--TQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNR-FALSSQ---R 113
Query: 1210 GNGLILYSLP-QRKNQQNLGLP------SLSSTAILMVTVADVPDEVEMSDKPVFISRYY 1262
G GLI +LP K +Q L + S TA +++ V D + +PVF S +Y
Sbjct: 114 GGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDA-----NTHRPVFQSSHY 168
Query: 1263 ELEIEEN--VNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRS 1320
+ + E+ V + +S N + EN ++ Y I D F IDP +GT+Y +
Sbjct: 169 TVSVSEDRPVGTSIATLSANDEDTGENARITYVI-----QDPVPQFRIDPDSGTMYTMME 223
Query: 1321 PDREVKDTYEVIVRAE 1336
D E + Y + + A+
Sbjct: 224 LDYENQVAYTLTIMAQ 239
Score = 44.0 bits (99), Expect = 0.004
Identities = 37/138 (26%), Positives = 62/138 (44%), Gaps = 7/138 (5%)
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
N S ++ +LD E + + + V+A P ++ V I +LD+NDN P F
Sbjct: 8 NSSGWITVCAELDRE---EVDHYSFGVEAVDHGWPPMSSSTSVSITVLDVNDNDPVFTQP 64
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQT 367
Y + + E+ G SVL + A D+D N TYQL + + F++ + G +
Sbjct: 65 TYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRNRFALSSQRGGGLITLAL 122
Query: 368 VLDREAHSSLRMKVYAKE 385
LD + + V A +
Sbjct: 123 PLDYKQEQQYVLAVTASD 140
Score = 34.3 bits (75), Expect = 3.4
Identities = 17/39 (43%), Positives = 23/39 (58%), Gaps = 1/39 (2%)
Query: 1441 ATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAAL 1479
A D D G NA I Y ++ + P+F IDP SGT+ + L
Sbjct: 187 ANDEDTGENARITY-VIQDPVPQFRIDPDSGTMYTMMEL 224
>D21255-1|BAA04799.1| 693|Homo sapiens OB-cadherin-2 protein.
Length = 693
Score = 125 bits (301), Expect = 1e-27
Identities = 124/465 (26%), Positives = 203/465 (43%), Gaps = 45/465 (9%)
Query: 711 NGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGI 770
+G GN++++++ + T + + G I K LDRE+R Y + A
Sbjct: 83 SGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPP 142
Query: 771 YQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF 830
+ + ++D NDNPP F H TY + E S +GT + A D G +A +Y++
Sbjct: 143 SEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSIL 202
Query: 831 GEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARD----TGGLSSEAELIIMIGDE 886
EG+ F V+ TG+++ ++DRE K Y + + A+D GGLS ++ I + D
Sbjct: 203 -EGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDV 261
Query: 887 NDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPI 946
NDN P+F Q S +I G + VK K+ D+ + G
Sbjct: 262 NDNPPKFPQ----SVYQI--SVSEAAVPGEEVGRVKAKDP---DIGENG----------- 301
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
++ N +D D + +I ++ ++ + K D E KR + + + A +
Sbjct: 302 ---LVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVD-FETKRAYSLK------VEAAN 351
Query: 1007 LPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGK 1066
+ + +F N G D ++V++ V+D D P+F Y V+E V+G+
Sbjct: 352 VHIDPKFISN------GPFKDTVTVKIAVEDA-DEPPMFLAPSYIHEVQENAAAGTVVGR 404
Query: 1067 VDATDADFGQNANLTYFI-QPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
V A D D N+ + Y I + +D D F I+P G + LDRE +TV A +
Sbjct: 405 VHAKDPD-AANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEI 463
Query: 1126 GXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSN 1170
DVNDN+PKF A E + + LSN
Sbjct: 464 -HNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSN 507
Score = 91.5 bits (217), Expect = 2e-17
Identities = 84/287 (29%), Positives = 132/287 (45%), Gaps = 22/287 (7%)
Query: 592 VGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQ 651
VG++ + ++ Y +L G G F ++++SG I L R R Y A A+
Sbjct: 74 VGRLHSDIDSGDGNIKY-ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVD 132
Query: 652 ENAN--LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENS-AGAAIGQIFHTNMSS- 707
+ N L + V V D+ND L H +V E S G ++ Q+ ++
Sbjct: 133 RDTNRPLEPPSEFIVKVQDINDNPPEFL---HETYHANVPERSNVGTSVIQVTASDADDP 189
Query: 708 IYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKP-LDREKRDVYRMTVIAEFNKGVIS 766
YGN V ++ Q + + A+ G I T P +DRE ++ Y + + A+ G +
Sbjct: 190 TYGNSAKLVYSILEGQPYFSVE---AQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMG 246
Query: 767 G-AGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALF 825
G +G +VTI + D NDNPP F + Y+ + E + G E+ +KA D D G N L
Sbjct: 247 GLSGTTKVTITLTDVNDNPPKFPQSVYQISVSEAAVPGEEV---GRVKAKDPDIGENGLV 303
Query: 826 MYTLF-GEGKEMF----DVDENTGVVKFIGDSLDREKKIMYKLSLVA 867
Y + G+G E F D + GV+K + +D E K Y L + A
Sbjct: 304 TYNIVDGDGMESFEITTDYETQEGVIK-LKKPVDFETKRAYSLKVEA 349
Score = 77.4 bits (182), Expect = 4e-13
Identities = 63/240 (26%), Positives = 102/240 (42%), Gaps = 11/240 (4%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L V +TL D NDN P F P ++Y+ S+ A G +G+VKA DPD+G+NG+V Y+
Sbjct: 248 LSGTTKVTITLTDVNDNPPKF-PQSVYQISVSEAAVPGEEVGRVKAKDPDIGENGLVTYN 306
Query: 499 L---QRTSNLTITSPFKINPNTGTVSVAESPILEGRHA--LFVEASDQPANPSERRYSLA 553
+ + IT+ ++ G + + + E + A L VEA++ +P
Sbjct: 307 IVDGDGMESFEITTDYE--TQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPF 364
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND-VSYDLLH 612
T+ V + + + P F+ Y V N GT VG++ D N + Y +
Sbjct: 365 KDTVTVKIAVE-DADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDR 423
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTNATVHVVDVND 671
+ F + G I L R + A + N + + V+DVND
Sbjct: 424 HTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVND 483
Score = 77.0 bits (181), Expect = 5e-13
Identities = 111/437 (25%), Positives = 181/437 (41%), Gaps = 57/437 (13%)
Query: 992 FVINERHGHVIVARSLPPE--SEFRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFK 1046
FVI+++ G++ ++L E +++ L A+D L V V+D+ND+ P F
Sbjct: 101 FVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFL 160
Query: 1047 KTWYNFNVEEAQYTRRVLGKVDATDAD---FGQNANLTYFIQPSDTDLPFEISPLTGVL- 1102
Y+ NV E + +V A+DAD +G +A L Y I F + TG++
Sbjct: 161 HETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPY--FSVEAQTGIIR 218
Query: 1103 SVNGELDRETEDKYILTVVARD-NGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWK 1161
+ +DRE +++Y + + A+D G DVNDN PKF + +
Sbjct: 219 TALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFP--QSVYQIS 276
Query: 1162 HPEADELSNHNFESVMMIPVYKATIEENAPIGTTVA-----KVFANDTDFIGNGNGLILY 1216
EA E V + I EN + + + F TD+ G+I
Sbjct: 277 VSEAAVPG----EEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDY-ETQEGVIKL 331
Query: 1217 SLP---QRKNQQNLGL--------PSLSSTAILMVTVADVPDEVEMSDKP-VFISRYYEL 1264
P + K +L + P S TV V VE +D+P +F++ Y
Sbjct: 332 KKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVT-VKIAVEDADEPPMFLAPSYIH 390
Query: 1265 EIEENVNAPVELVSLNLTE-HYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDR 1323
E++EN A + ++ + N +RY I + TD+ R F I+P +G + + DR
Sbjct: 391 EVQENAAAGTVVGRVHAKDPDAANSPIRYSI--DRHTDLDRFFTINPEDGFIKTTKPLDR 448
Query: 1324 EVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNG 1383
E + V ++ E+ H + A+ V V +R+ DVNDN+PKF
Sbjct: 449 EETAWLNITV------FAAEI-HNRHQEAK----------VPVAIRVLDVNDNAPKFAAP 491
Query: 1384 NRPLVTAIPTTAPFGYQ 1400
+ T P Q
Sbjct: 492 YEGFICESDQTKPLSNQ 508
Score = 76.2 bits (179), Expect = 9e-13
Identities = 118/455 (25%), Positives = 190/455 (41%), Gaps = 53/455 (11%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVD---PDLGQNGMVLYDLQRTS 503
V + D NDN P F+ Y ++ + VGT + +V A D P G + ++Y +
Sbjct: 147 VKVQDINDNPPEFLHET-YHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSI---- 201
Query: 504 NLTITSPFKINPNTGTVSVA----ESPILEGRHALFVEASDQPANPSERRYSLAVVTIEV 559
L F + TG + A + E H + ++A D + VTI +
Sbjct: 202 -LEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVV-IQAKDMGGHMGGLS-GTTKVTITL 258
Query: 560 TRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAF--EQNDVSYDLLHGYEEG 617
T N P P + Y+ V G VG+++ D E V+Y+++ G +G
Sbjct: 259 T-DVNDNPPKFPQSV---YQISVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDG--DG 312
Query: 618 VP-FAV----EERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNA------TVHV 666
+ F + E + GVI + + + Y + A + + ++N TV +
Sbjct: 313 MESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKI 372
Query: 667 -VDVNDERGVLLKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
V+ DE + L ++ I V+EN+A G +G++ + + +R+ I
Sbjct: 373 AVEDADEPPMFLAPSY---IHEVQENAAAGTVVGRVHAKDPDA----ANSPIRYSIDRHT 425
Query: 725 DVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDN 783
D+ I EDG I T KPLDRE+ +TV A A + V I + D NDN
Sbjct: 426 DLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKV-PVAIRVLDVNDN 484
Query: 784 PPVFEHATYEGFIMENSKIGTEIKMDNI-IKATDADEGTNA-LFMYTLFGE-----GKEM 836
P F A YEGFI E+ + + I A D D+ N F+++L E +
Sbjct: 485 APKFA-APYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPNFTV 543
Query: 837 FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG 871
D +NT V R+K+ +Y L +V D G
Sbjct: 544 RDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGG 578
Score = 62.5 bits (145), Expect = 1e-08
Identities = 47/167 (28%), Positives = 81/167 (48%), Gaps = 9/167 (5%)
Query: 222 DQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQL 281
D D G G ++Y L +F +D +G++ K LD E Q T + Q
Sbjct: 80 DIDSGDG-NIKYILSGEGAGTIFVIDDKSGNIHATKTLD--REERAQY-TLMAQAVDRDT 135
Query: 282 NNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ---GEN 338
N PL+ + +++ D+NDN PEF + Y+ ++ E G SV+QV A+D D G +
Sbjct: 136 NRPLEPPSEFI-VKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNS 194
Query: 339 GEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ Y + + + FS++ ++G + +DREA + + AK+
Sbjct: 195 AKLVYSILEGQPYFSVEAQTGIIRTALPN-MDREAKEEYHVVIQAKD 240
Score = 54.4 bits (125), Expect = 3e-06
Identities = 48/171 (28%), Positives = 79/171 (46%), Gaps = 14/171 (8%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLE-KELDLDAEHNLQANTFVLQVQA 278
A D G A L Y ++ G + FS+++ G + +D +A+ + + +QA
Sbjct: 186 ADDPTYGNSAKLVYSILEG--QPYFSVEAQTGIIRTALPNMDREAKEE-----YHVVIQA 238
Query: 279 SQLNNPLK--TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+ + + +V I L D+NDN P+F Y IS+ E G V +V A D D G
Sbjct: 239 KDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQISVSEAAVPGEEVGRVKAKDPDIG 298
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLT----VRNQTVLDREAHSSLRMKVYA 383
ENG TY + D G S + + + T ++ + +D E + +KV A
Sbjct: 299 ENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEA 349
Score = 48.0 bits (109), Expect = 3e-04
Identities = 55/221 (24%), Positives = 88/221 (39%), Gaps = 33/221 (14%)
Query: 926 KFALDVDQLGPLFLIP-------ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
K A++ P+FL P EN GT + +++A D D+ N IRY +
Sbjct: 371 KIAVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAA-NSPIRYSIDRHT---- 425
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISA----LDGGNLNDNISVRVF 1034
++ R+F IN G + + L E LNI+ + + + V +
Sbjct: 426 --------DLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIR 477
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQ---YTRRVLGKVDATDADFGQNANLTYFIQPSDT-- 1089
V DVND+ P F + F E Q + + + + A D D N F P +
Sbjct: 478 VLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIH 537
Query: 1090 DLPFEISP----LTGVLSVNGELDRETEDKYILTVVARDNG 1126
+ F + GV + G R+ +D Y+L +V D G
Sbjct: 538 NPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGG 578
Score = 45.6 bits (103), Expect = 0.001
Identities = 36/133 (27%), Positives = 63/133 (47%), Gaps = 11/133 (8%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR-KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+HA D D + +RY + D + F+++ +G F++ LD E N + V
Sbjct: 405 VHAKDPD-AANSPIRYSIDRHTDLDRFFTINPEDG--FIKTTKPLDREETAWLN---ITV 458
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFS---VLQVMATDK 333
A++++N + A+ V I +LD+NDN P+F + + S ++ + A DK
Sbjct: 459 FAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDK 518
Query: 334 DQGENG-EFTYQL 345
D NG F + L
Sbjct: 519 DDTANGPRFIFSL 531
Score = 36.7 bits (81), Expect = 0.64
Identities = 27/114 (23%), Positives = 54/114 (47%), Gaps = 18/114 (15%)
Query: 1306 FVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVK 1365
FVID ++G ++ ++ DRE + Y ++ +A + +R L P +E
Sbjct: 101 FVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLE----PPSE------------ 144
Query: 1366 VVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQLKGAIGHHPTASRTVR 1419
+V+++D+NDN P+F + +P + G V+Q+ + PT + +
Sbjct: 145 FIVKVQDINDNPPEFL--HETYHANVPERSNVGTSVIQVTASDADDPTYGNSAK 196
Score = 35.9 bits (79), Expect = 1.1
Identities = 16/46 (34%), Positives = 25/46 (54%)
Query: 70 IGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEK 115
+G + +S VT+ + DVNDN P F + Y ++V E GE+
Sbjct: 241 MGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQISVSEAAVPGEE 286
>D21254-1|BAA04798.1| 796|Homo sapiens OB-cadherin-1 protein.
Length = 796
Score = 125 bits (301), Expect = 1e-27
Identities = 124/465 (26%), Positives = 203/465 (43%), Gaps = 45/465 (9%)
Query: 711 NGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGI 770
+G GN++++++ + T + + G I K LDRE+R Y + A
Sbjct: 83 SGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPP 142
Query: 771 YQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF 830
+ + ++D NDNPP F H TY + E S +GT + A D G +A +Y++
Sbjct: 143 SEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSIL 202
Query: 831 GEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARD----TGGLSSEAELIIMIGDE 886
EG+ F V+ TG+++ ++DRE K Y + + A+D GGLS ++ I + D
Sbjct: 203 -EGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDV 261
Query: 887 NDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPI 946
NDN P+F Q S +I G + VK K+ D+ + G
Sbjct: 262 NDNPPKFPQ----SVYQI--SVSEAAVPGEEVGRVKAKDP---DIGENG----------- 301
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
++ N +D D + +I ++ ++ + K D E KR + + + A +
Sbjct: 302 ---LVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVD-FETKRAYSLK------VEAAN 351
Query: 1007 LPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGK 1066
+ + +F N G D ++V++ V+D D P+F Y V+E V+G+
Sbjct: 352 VHIDPKFISN------GPFKDTVTVKIAVEDA-DEPPMFLAPSYIHEVQENAAAGTVVGR 404
Query: 1067 VDATDADFGQNANLTYFI-QPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
V A D D N+ + Y I + +D D F I+P G + LDRE +TV A +
Sbjct: 405 VHAKDPD-AANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEI 463
Query: 1126 GXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSN 1170
DVNDN+PKF A E + + LSN
Sbjct: 464 -HNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSN 507
Score = 91.5 bits (217), Expect = 2e-17
Identities = 84/287 (29%), Positives = 132/287 (45%), Gaps = 22/287 (7%)
Query: 592 VGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQ 651
VG++ + ++ Y +L G G F ++++SG I L R R Y A A+
Sbjct: 74 VGRLHSDIDSGDGNIKY-ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVD 132
Query: 652 ENAN--LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENS-AGAAIGQIFHTNMSS- 707
+ N L + V V D+ND L H +V E S G ++ Q+ ++
Sbjct: 133 RDTNRPLEPPSEFIVKVQDINDNPPEFL---HETYHANVPERSNVGTSVIQVTASDADDP 189
Query: 708 IYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKP-LDREKRDVYRMTVIAEFNKGVIS 766
YGN V ++ Q + + A+ G I T P +DRE ++ Y + + A+ G +
Sbjct: 190 TYGNSAKLVYSILEGQPYFSVE---AQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMG 246
Query: 767 G-AGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALF 825
G +G +VTI + D NDNPP F + Y+ + E + G E+ +KA D D G N L
Sbjct: 247 GLSGTTKVTITLTDVNDNPPKFPQSVYQISVSEAAVPGEEV---GRVKAKDPDIGENGLV 303
Query: 826 MYTLF-GEGKEMF----DVDENTGVVKFIGDSLDREKKIMYKLSLVA 867
Y + G+G E F D + GV+K + +D E K Y L + A
Sbjct: 304 TYNIVDGDGMESFEITTDYETQEGVIK-LKKPVDFETKRAYSLKVEA 349
Score = 77.4 bits (182), Expect = 4e-13
Identities = 63/240 (26%), Positives = 102/240 (42%), Gaps = 11/240 (4%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L V +TL D NDN P F P ++Y+ S+ A G +G+VKA DPD+G+NG+V Y+
Sbjct: 248 LSGTTKVTITLTDVNDNPPKF-PQSVYQISVSEAAVPGEEVGRVKAKDPDIGENGLVTYN 306
Query: 499 L---QRTSNLTITSPFKINPNTGTVSVAESPILEGRHA--LFVEASDQPANPSERRYSLA 553
+ + IT+ ++ G + + + E + A L VEA++ +P
Sbjct: 307 IVDGDGMESFEITTDYE--TQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPF 364
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND-VSYDLLH 612
T+ V + + + P F+ Y V N GT VG++ D N + Y +
Sbjct: 365 KDTVTVKIAVE-DADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDR 423
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTNATVHVVDVND 671
+ F + G I L R + A + N + + V+DVND
Sbjct: 424 HTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVND 483
Score = 77.0 bits (181), Expect = 5e-13
Identities = 111/437 (25%), Positives = 181/437 (41%), Gaps = 57/437 (13%)
Query: 992 FVINERHGHVIVARSLPPE--SEFRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFK 1046
FVI+++ G++ ++L E +++ L A+D L V V+D+ND+ P F
Sbjct: 101 FVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFL 160
Query: 1047 KTWYNFNVEEAQYTRRVLGKVDATDAD---FGQNANLTYFIQPSDTDLPFEISPLTGVL- 1102
Y+ NV E + +V A+DAD +G +A L Y I F + TG++
Sbjct: 161 HETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPY--FSVEAQTGIIR 218
Query: 1103 SVNGELDRETEDKYILTVVARD-NGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWK 1161
+ +DRE +++Y + + A+D G DVNDN PKF + +
Sbjct: 219 TALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFP--QSVYQIS 276
Query: 1162 HPEADELSNHNFESVMMIPVYKATIEENAPIGTTVA-----KVFANDTDFIGNGNGLILY 1216
EA E V + I EN + + + F TD+ G+I
Sbjct: 277 VSEAAVPG----EEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDY-ETQEGVIKL 331
Query: 1217 SLP---QRKNQQNLGL--------PSLSSTAILMVTVADVPDEVEMSDKP-VFISRYYEL 1264
P + K +L + P S TV V VE +D+P +F++ Y
Sbjct: 332 KKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVT-VKIAVEDADEPPMFLAPSYIH 390
Query: 1265 EIEENVNAPVELVSLNLTE-HYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDR 1323
E++EN A + ++ + N +RY I + TD+ R F I+P +G + + DR
Sbjct: 391 EVQENAAAGTVVGRVHAKDPDAANSPIRYSI--DRHTDLDRFFTINPEDGFIKTTKPLDR 448
Query: 1324 EVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNG 1383
E + V ++ E+ H + A+ V V +R+ DVNDN+PKF
Sbjct: 449 EETAWLNITV------FAAEI-HNRHQEAK----------VPVAIRVLDVNDNAPKFAAP 491
Query: 1384 NRPLVTAIPTTAPFGYQ 1400
+ T P Q
Sbjct: 492 YEGFICESDQTKPLSNQ 508
Score = 76.2 bits (179), Expect = 9e-13
Identities = 118/455 (25%), Positives = 190/455 (41%), Gaps = 53/455 (11%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVD---PDLGQNGMVLYDLQRTS 503
V + D NDN P F+ Y ++ + VGT + +V A D P G + ++Y +
Sbjct: 147 VKVQDINDNPPEFLHET-YHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSI---- 201
Query: 504 NLTITSPFKINPNTGTVSVA----ESPILEGRHALFVEASDQPANPSERRYSLAVVTIEV 559
L F + TG + A + E H + ++A D + VTI +
Sbjct: 202 -LEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVV-IQAKDMGGHMGGLS-GTTKVTITL 258
Query: 560 TRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAF--EQNDVSYDLLHGYEEG 617
T N P P + Y+ V G VG+++ D E V+Y+++ G +G
Sbjct: 259 T-DVNDNPPKFPQSV---YQISVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDG--DG 312
Query: 618 VP-FAV----EERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNA------TVHV 666
+ F + E + GVI + + + Y + A + + ++N TV +
Sbjct: 313 MESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKI 372
Query: 667 -VDVNDERGVLLKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
V+ DE + L ++ I V+EN+A G +G++ + + +R+ I
Sbjct: 373 AVEDADEPPMFLAPSY---IHEVQENAAAGTVVGRVHAKDPDA----ANSPIRYSIDRHT 425
Query: 725 DVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDN 783
D+ I EDG I T KPLDRE+ +TV A A + V I + D NDN
Sbjct: 426 DLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKV-PVAIRVLDVNDN 484
Query: 784 PPVFEHATYEGFIMENSKIGTEIKMDNI-IKATDADEGTNA-LFMYTLFGE-----GKEM 836
P F A YEGFI E+ + + I A D D+ N F+++L E +
Sbjct: 485 APKFA-APYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPNFTV 543
Query: 837 FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG 871
D +NT V R+K+ +Y L +V D G
Sbjct: 544 RDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGG 578
Score = 62.5 bits (145), Expect = 1e-08
Identities = 47/167 (28%), Positives = 81/167 (48%), Gaps = 9/167 (5%)
Query: 222 DQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQL 281
D D G G ++Y L +F +D +G++ K LD E Q T + Q
Sbjct: 80 DIDSGDG-NIKYILSGEGAGTIFVIDDKSGNIHATKTLD--REERAQY-TLMAQAVDRDT 135
Query: 282 NNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ---GEN 338
N PL+ + +++ D+NDN PEF + Y+ ++ E G SV+QV A+D D G +
Sbjct: 136 NRPLEPPSEFI-VKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNS 194
Query: 339 GEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+ Y + + + FS++ ++G + +DREA + + AK+
Sbjct: 195 AKLVYSILEGQPYFSVEAQTGIIRTALPN-MDREAKEEYHVVIQAKD 240
Score = 54.4 bits (125), Expect = 3e-06
Identities = 48/171 (28%), Positives = 79/171 (46%), Gaps = 14/171 (8%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLE-KELDLDAEHNLQANTFVLQVQA 278
A D G A L Y ++ G + FS+++ G + +D +A+ + + +QA
Sbjct: 186 ADDPTYGNSAKLVYSILEG--QPYFSVEAQTGIIRTALPNMDREAKEE-----YHVVIQA 238
Query: 279 SQLNNPLK--TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+ + + +V I L D+NDN P+F Y IS+ E G V +V A D D G
Sbjct: 239 KDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQISVSEAAVPGEEVGRVKAKDPDIG 298
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLT----VRNQTVLDREAHSSLRMKVYA 383
ENG TY + D G S + + + T ++ + +D E + +KV A
Sbjct: 299 ENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEA 349
Score = 48.0 bits (109), Expect = 3e-04
Identities = 55/221 (24%), Positives = 88/221 (39%), Gaps = 33/221 (14%)
Query: 926 KFALDVDQLGPLFLIP-------ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
K A++ P+FL P EN GT + +++A D D+ N IRY +
Sbjct: 371 KIAVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAA-NSPIRYSIDRHT---- 425
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISA----LDGGNLNDNISVRVF 1034
++ R+F IN G + + L E LNI+ + + + V +
Sbjct: 426 --------DLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIR 477
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQ---YTRRVLGKVDATDADFGQNANLTYFIQPSDT-- 1089
V DVND+ P F + F E Q + + + + A D D N F P +
Sbjct: 478 VLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIH 537
Query: 1090 DLPFEISP----LTGVLSVNGELDRETEDKYILTVVARDNG 1126
+ F + GV + G R+ +D Y+L +V D G
Sbjct: 538 NPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGG 578
Score = 45.6 bits (103), Expect = 0.001
Identities = 36/133 (27%), Positives = 63/133 (47%), Gaps = 11/133 (8%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR-KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+HA D D + +RY + D + F+++ +G F++ LD E N + V
Sbjct: 405 VHAKDPD-AANSPIRYSIDRHTDLDRFFTINPEDG--FIKTTKPLDREETAWLN---ITV 458
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFS---VLQVMATDK 333
A++++N + A+ V I +LD+NDN P+F + + S ++ + A DK
Sbjct: 459 FAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDK 518
Query: 334 DQGENG-EFTYQL 345
D NG F + L
Sbjct: 519 DDTANGPRFIFSL 531
Score = 36.7 bits (81), Expect = 0.64
Identities = 27/114 (23%), Positives = 54/114 (47%), Gaps = 18/114 (15%)
Query: 1306 FVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVK 1365
FVID ++G ++ ++ DRE + Y ++ +A + +R L P +E
Sbjct: 101 FVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLE----PPSE------------ 144
Query: 1366 VVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQLKGAIGHHPTASRTVR 1419
+V+++D+NDN P+F + +P + G V+Q+ + PT + +
Sbjct: 145 FIVKVQDINDNPPEFL--HETYHANVPERSNVGTSVIQVTASDADDPTYGNSAK 196
Score = 35.9 bits (79), Expect = 1.1
Identities = 16/46 (34%), Positives = 25/46 (54%)
Query: 70 IGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEK 115
+G + +S VT+ + DVNDN P F + Y ++V E GE+
Sbjct: 241 MGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQISVSEAAVPGEE 286
>AB006756-1|BAA25195.1| 1072|Homo sapiens PCDH7 (BH-Pcdh)b protein.
Length = 1072
Score = 123 bits (297), Expect = 4e-27
Identities = 168/643 (26%), Positives = 266/643 (41%), Gaps = 75/643 (11%)
Query: 744 LDREKRDVYRMTV-IAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKI 802
LDRE+RD Y +T+ + + S I +V I D NDN P FE + YE + ENS
Sbjct: 266 LDREQRDSYELTLRVRDGGDPPRSSQAILRVLI--TDVNDNSPRFEKSVYEADLAENSAP 323
Query: 803 GTEIKMDNIIKATDADEGTNALFMYTLFGEGKE----MFDVDENTGVVKFIGDSLDREKK 858
GT I ++A D D G N Y +FG E + +DE +G + + +DRE+
Sbjct: 324 GTPILQ---LRAADLDVGVNGQIEY-VFGAATESVRRLLRLDETSGWLSVL-HRIDREEV 378
Query: 859 IMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGF 916
+ +++ARD G + +A +++ I DENDN P IE RI + + A
Sbjct: 379 NQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVP---SIEIRKIGRIPLKDGVANVAED 435
Query: 917 TIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYI 976
+++ D DQ EN + T++ G + ++
Sbjct: 436 VLVDTPIALVQVSDRDQ-------GENGVVTCTVV------------GDVPFQLK----- 471
Query: 977 PPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGG--NLNDNISVRVF 1034
P S D K+YF+ H EF + I A+D G +L+ S+ V
Sbjct: 472 PASDTEGDQ-NKKKYFL------HTSTPLDYEATREFNVVIVAVDSGSPSLSSKNSLIVK 524
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFE 1094
V D ND+ P+F ++ E + V ATDAD G+NA + Y + S + F
Sbjct: 525 VGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGI-FA 583
Query: 1095 ISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAF 1154
I P +G + VN LDRE D+Y V A+D G D NDN PKF
Sbjct: 584 IDPDSGDILVNTVLDREQTDRYEFKVNAKDKG-IPVLQGSTTVIVQVADKNDNDPKF--M 640
Query: 1155 DELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLI 1214
++ + E + ++ V M+ V A NA + + + N+ I N G I
Sbjct: 641 QDVFTFYVKENLQPNS----PVGMVTVMDADKGRNAEMSLYIEE--NNNIFSIENDTGTI 694
Query: 1215 LYSLPQRKNQQNL----------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYEL 1264
++ + Q G P S+TA + + V D D P IS Y L
Sbjct: 695 YSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPKNIS-YTLL 753
Query: 1265 EIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDRE 1324
NV V V ++ N + Y I+ N + F IDP +G + LV ++
Sbjct: 754 PPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPF---KLFEIDPTSGVVSLVGKLTQK 810
Query: 1325 VKDTYEVIVRA-ERQKYSRELPHMIYPVAEDVLEGMTKYDVKV 1366
+ ++V+ + + S+ +++ + + T D ++
Sbjct: 811 HYGLHRLVVQVNDSGQPSQSTTTVVHVFVNESVSNATAIDSQI 853
Score = 95.1 bits (226), Expect = 2e-18
Identities = 122/470 (25%), Positives = 205/470 (43%), Gaps = 46/470 (9%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
+ V + D NDN+P F S +YE + N+ GT I +++A D D+G NG + Y +
Sbjct: 294 LRVLITDVNDNSPRFEKS-VYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATE 352
Query: 505 LTITSPFKINPNTGTVSVAESPILEGRHAL--FVEASDQPANPSERRYSLAVVTIEVTRG 562
++ +++ +G +SV E + L V A D+ P + A V + + +
Sbjct: 353 -SVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDK---ATVVLNI-KD 407
Query: 563 TKGNKP--DIPDFMGAPYEFWVGS---NVGIGTSVGQIRVNDAFE-QNDVSYDLLHGYEE 616
N P +I P + V + +V + T + ++V+D + +N V + G
Sbjct: 408 ENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVG--- 464
Query: 617 GVPFAVEERSGVITVVDDLSRY---NRPMYDFEA--------VALQENA-NLSIVTNATV 664
VPF ++ S + + + P+ D+EA VA+ + +LS + V
Sbjct: 465 DVPFQLKPASDTEGDQNKKKYFLHTSTPL-DYEATREFNVVIVAVDSGSPSLSSKNSLIV 523
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
V D ND + G ++ + N G + + T+ S G N +
Sbjct: 524 KVGDTNDNPPMF--GQSVVEVYFPENNIPGERVATVLATDADS--GK---NAEIAYSLDS 576
Query: 725 DVTDDIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDN 783
V AI D G I LDRE+ D Y V A+ +KG+ G V + + D+NDN
Sbjct: 577 SVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAK-DKGIPVLQGSTTVIVQVADKNDN 635
Query: 784 PPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENT 843
P F + ++ EN + + + M + DAD+G NA M E +F ++ +T
Sbjct: 636 DPKFMQDVFTFYVKENLQPNSPVGM---VTVMDADKGRNA-EMSLYIEENNNIFSIENDT 691
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKP 891
G + + S DRE + Y + A D G S+ A + + + DENDN P
Sbjct: 692 GTI-YSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAP 740
Score = 81.0 bits (191), Expect = 3e-14
Identities = 111/413 (26%), Positives = 173/413 (41%), Gaps = 56/413 (13%)
Query: 996 ERHGHVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYN 1051
E+ +IV +L E + L + DGG+ + +RV + DVND+ P F+K+ Y
Sbjct: 255 EKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYE 314
Query: 1052 FNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP--FEISPLTGVLSVNGELD 1109
++ E + ++ A D D G N + Y + + + +G LSV +D
Sbjct: 315 ADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRID 374
Query: 1110 RETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELS 1169
RE ++ TV+ARD G D NDN P + + + P D ++
Sbjct: 375 REEVNQLRFTVMARDRG-QPPKTDKATVVLNIKDENDNVP---SIEIRKIGRIPLKDGVA 430
Query: 1170 NHNFESVMMIPVYKATIE-----ENAPIGTTVAKVF------ANDTDFIGNGNGLILY-S 1217
N + ++ P+ + EN + TV A+DT+ N L+ S
Sbjct: 431 NVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTS 490
Query: 1218 LP---QRKNQQNL-------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIE 1267
P + + N+ G PSLSS L+V V D D + P+F E+
Sbjct: 491 TPLDYEATREFNVVIVAVDSGSPSLSSKNSLIVKVGDTND-----NPPMFGQSVVEVYFP 545
Query: 1268 ENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKD 1327
EN N P E V+ L ++ K I D+ + F IDP +G + + DRE D
Sbjct: 546 EN-NIPGERVATVLATDADSGK-NAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDREQTD 603
Query: 1328 TYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF 1380
YE V A+ + +P VL+G T V+V++ D NDN PKF
Sbjct: 604 RYEFKVNAK----DKGIP---------VLQGST----TVIVQVADKNDNDPKF 639
Score = 81.0 bits (191), Expect = 3e-14
Identities = 49/160 (30%), Positives = 81/160 (50%), Gaps = 7/160 (4%)
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
+ T PLD E + + ++A + G S + + + + D NDNPP+F + E +
Sbjct: 487 LHTSTPLDYEATREFNVVIVA-VDSGSPSLSSKNSLIVKVGDTNDNPPMFGQSVVEVYFP 545
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREK 857
EN+ G + + ATDAD G NA Y+L +F +D ++G + + LDRE+
Sbjct: 546 ENNIPGERVA---TVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDI-LVNTVLDREQ 601
Query: 858 KIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ 895
Y+ + A+D G L +I+ + D+NDN P+F Q
Sbjct: 602 TDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQ 641
Score = 80.2 bits (189), Expect = 5e-14
Identities = 106/464 (22%), Positives = 197/464 (42%), Gaps = 52/464 (11%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAK-------VGTVIGKVKAVDPDLGQNGMVLY 497
V + + D NDN P + +K V T I V+ D D G+NG+V
Sbjct: 401 VVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVV-- 458
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTI 557
T + PF++ P + T + + F+ S + R +++ +V +
Sbjct: 459 ----TCTVVGDVPFQLKPASDTEGD------QNKKKYFLHTSTPLDYEATREFNVVIVAV 508
Query: 558 EV---TRGTK-------GNKPDIPDFMG-APYEFWVGSNVGIGTSVGQIRVNDAF--EQN 604
+ + +K G+ D P G + E + N G V + DA +
Sbjct: 509 DSGSPSLSSKNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNA 568
Query: 605 DVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
+++Y L G+ FA++ SG I V L R Y+F+ A ++ + ++ +T
Sbjct: 569 EIAYSL-DSSVMGI-FAIDPDSGDILVNTVLDREQTDRYEFKVNA--KDKGIPVLQGSTT 624
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
+V V D+ K F+VKEN + +G + T M + G ++ N
Sbjct: 625 VIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMV--TVMDADKGRNAEMSLYIEENN 682
Query: 724 QDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDN 783
+ + + GTI++ DRE + Y V A + G + V++++ DENDN
Sbjct: 683 NIFSIE---NDTGTIYSTMSFDREHQTTYTFRVKA-VDGGDPPRSATATVSLFVMDENDN 738
Query: 784 PPVF---EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGK-EMFDV 839
P ++ +Y + +S + T + + ATD+D+G NA Y++ G ++F++
Sbjct: 739 APTVTLPKNISYT-LLPPSSNVRTVVAT---VLATDSDDGINADLNYSIVGGNPFKLFEI 794
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMI 883
D +GVV +G L ++ +++L + D+G S ++ +
Sbjct: 795 DPTSGVVSLVG-KLTQKHYGLHRLVVQVNDSGQPSQSTTTVVHV 837
Score = 71.7 bits (168), Expect = 2e-11
Identities = 103/448 (22%), Positives = 184/448 (41%), Gaps = 58/448 (12%)
Query: 268 QANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQ 327
Q +++ L ++ +P +++QA + + + D+NDN P FE Y + EN G +LQ
Sbjct: 270 QRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQ 329
Query: 328 VMATDKDQGENGEFTY----QLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
+ A D D G NG+ Y + + +D SGWL+V ++ +DRE + LR V A
Sbjct: 330 LRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHR--IDREEVNQLRFTVMA 387
Query: 384 KETNPSVVGTFADSQRIAKWRRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLMSFV 443
++ R QP +T +K T V + + +N+ + + + +
Sbjct: 388 RD------------------RGQPPKT----DKATVVL--NIKDENDNVPSIEIRKIGRI 423
Query: 444 NVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVG----TVIGKV----KAVDPDLGQNGMV 495
++ + + ++ V P L + S + + G TV+G V K G
Sbjct: 424 PLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKK 483
Query: 496 LYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVV 555
Y L ++ L + + N V + SP L +++L V+ D NP S+ V
Sbjct: 484 KYFLHTSTPLDYEATREFNVVIVAVD-SGSPSLSSKNSLIVKVGDTNDNPPMFGQSVVEV 542
Query: 556 -----TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNV----GIGTSVGQIRVNDAF--EQN 604
I R D A + + S+V I G I VN EQ
Sbjct: 543 YFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDREQT 602
Query: 605 DVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
D ++ ++G+P + ++ V D + M D ++EN + N+ V
Sbjct: 603 DRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKEN----LQPNSPV 658
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENS 692
+V V D KG ++ + +++EN+
Sbjct: 659 GMVTVMDAD----KGRNAEMSLYIEENN 682
Score = 69.7 bits (163), Expect = 7e-11
Identities = 47/133 (35%), Positives = 65/133 (48%), Gaps = 6/133 (4%)
Query: 254 FLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNI 313
FL LD E + N ++ V + +P +++ + +++ D NDN P F +
Sbjct: 486 FLHTSTPLDYEATREFNVVIVAVDSG---SPSLSSKNSLIVKVGDTNDNPPMFGQSVVEV 542
Query: 314 SIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDP-KGAFSIDPRSGWLTVRNQTVLDRE 372
EN G V V+ATD D G+N E Y LD G F+IDP SG + V TVLDRE
Sbjct: 543 YFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILV--NTVLDRE 600
Query: 373 AHSSLRMKVYAKE 385
KV AK+
Sbjct: 601 QTDRYEFKVNAKD 613
Score = 66.5 bits (155), Expect = 7e-10
Identities = 45/164 (27%), Positives = 76/164 (46%), Gaps = 8/164 (4%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D G A + Y L S + +F++D +G + + LD + Q + + +V A
Sbjct: 559 ATDADSGKNAEIAYSLDS-SVMGIFAIDPDSGDILVNTVLDRE-----QTDRYEFKVNAK 612
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
P+ V +++ D NDN P+F D + + ENL V V D D+G N
Sbjct: 613 DKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNA 672
Query: 340 EFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
E + +++ FSI+ +G T+ + DRE ++ +V A
Sbjct: 673 EMSLYIEENNNIFSIENDTG--TIYSTMSFDREHQTTYTFRVKA 714
Score = 66.1 bits (154), Expect = 9e-10
Identities = 78/308 (25%), Positives = 127/308 (41%), Gaps = 28/308 (9%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
+V + +G +S+ S+ V + D NDN P+F + V E GE+ L
Sbjct: 505 IVAVDSGSPSLSSKNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADS 564
Query: 127 SLTIPLTVPRGLTIFKDIRAFDRDK----PNT----PNSDVHYSIVSGNDDGHFALESSH 178
+ ++ I A D D NT +D + V+ D G L+ S
Sbjct: 565 GKNAEIAYSLDSSVM-GIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGS- 622
Query: 179 KPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFP-EPIHAID-QDLGVGATLRYELI 236
++ +V D + D +F + KE L P P+ + D G L
Sbjct: 623 --TTVIVQVADKNDNDPKFMQDVFTF---YVKENLQPNSPVGMVTVMDADKGRNAEMSLY 677
Query: 237 SGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
+ +FS+++ G+++ + D EH T+ +V+A +P ++A A V + +
Sbjct: 678 IEENNNIFSIENDTGTIY--STMSFDREHQ---TTYTFRVKAVDGGDPPRSATATVSLFV 732
Query: 297 LDLNDNLPEFEVDFYNISIVENLPNG---FSVLQVMATDKDQGENGEFTYQL--DDPKGA 351
+D NDN P + NIS P+ V V+ATD D G N + Y + +P
Sbjct: 733 MDENDNAPTVTLP-KNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKL 791
Query: 352 FSIDPRSG 359
F IDP SG
Sbjct: 792 FEIDPTSG 799
Score = 59.7 bits (138), Expect = 8e-08
Identities = 63/248 (25%), Positives = 109/248 (43%), Gaps = 22/248 (8%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLI-AN 722
V + DVND K + + ENSA I + + G + ++ A
Sbjct: 296 VLITDVNDNSPRFEKSVYEA---DLAENSAPGT--PILQLRAADLDVGVNGQIEYVFGAA 350
Query: 723 QQDVTDDIAIAE-DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
+ V + + E G + +DRE+ + R TV+A ++G V + I+DEN
Sbjct: 351 TESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMAR-DRGQPPKTDKATVVLNIKDEN 409
Query: 782 DNPPVFEHATYEGFIMEN--SKIGTEIKMDN---IIKATDADEGTNALFMYTLFGEG--- 833
DN P E +++ + + ++ +D +++ +D D+G N + T+ G+
Sbjct: 410 DNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQ 469
Query: 834 -KEMFDVDENTGVVKFI---GDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDEN 887
K D + + K+ LD E + + +VA D+G LSS+ LI+ +GD N
Sbjct: 470 LKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSKNSLIVKVGDTN 529
Query: 888 DNKPEFNQ 895
DN P F Q
Sbjct: 530 DNPPMFGQ 537
Score = 52.4 bits (120), Expect = 1e-05
Identities = 75/308 (24%), Positives = 134/308 (43%), Gaps = 28/308 (9%)
Query: 364 RNQTVLDREAHSSLRMKVYAKETNPSVVGTFADSQRIAKWRRQPLETNAPLEKT-TYVFP 422
R TVL +A S ++ A + SV+G FA + N L++ T +
Sbjct: 553 RVATVLATDADSGKNAEI-AYSLDSSVMGIFAIDPDSGD-----ILVNTVLDREQTDRYE 606
Query: 423 DKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKV 482
KV K + I L V V + D NDN+P F+ +++ F +K N + + +G V
Sbjct: 607 FKVNAKDKGIPV----LQGSTTVIVQVADKNDNDPKFM-QDVFTFYVKENLQPNSPVGMV 661
Query: 483 KAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASD 540
+D D G+N + ++ +N+ F I +TGT+ S E + + V+A D
Sbjct: 662 TVMDADKGRNAEMSLYIEENNNI-----FSIENDTGTIYSTMSFDREHQTTYTFRVKAVD 716
Query: 541 QPANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA 600
P R + A V++ V N P + Y S+ + T V + D+
Sbjct: 717 GGDPP---RSATATVSLFV-MDENDNAPTVTLPKNISYTLLPPSS-NVRTVVATVLATDS 771
Query: 601 FE--QNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSI 658
+ D++Y ++ G + F ++ SGV+++V L++ + ++ V + ++ S
Sbjct: 772 DDGINADLNYSIVGGNPFKL-FEIDPTSGVVSLVGKLTQKHYGLHRL-VVQVNDSGQPSQ 829
Query: 659 VTNATVHV 666
T VHV
Sbjct: 830 STTTVVHV 837
Score = 52.0 bits (119), Expect = 2e-05
Identities = 82/364 (22%), Positives = 145/364 (39%), Gaps = 49/364 (13%)
Query: 218 IHAIDQDLGVGATLRYELISGND--RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A D D+GV + Y + + R+L LD +G L + +D + + N
Sbjct: 330 LRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDRE-----EVNQLRFT 384
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN--------ISIVENLPNGFSVLQ 327
V A P KT +A V + + D NDN+P E+ ++ E++ +
Sbjct: 385 VMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIAL 444
Query: 328 VMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA-K 384
V +D+DQGENG T + D P F + P S T +Q H+S + A +
Sbjct: 445 VQVSDRDQGENGVVTCTVVGDVP---FQLKPASD--TEGDQNKKKYFLHTSTPLDYEATR 499
Query: 385 ETNPSVVGTFADSQRIAKWRRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLMSFVN 444
E N +V + S ++ ++ T P G + + + +
Sbjct: 500 EFNVVIVAVDSGSPSLSSKNSLIVKVG-----DTNDNPPMFGQSVVEVYFPENNIPGERV 554
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V DA+ + +S+ S +V+G + A+DPD +G +L +
Sbjct: 555 ATVLATDADSGKNAEI-----AYSLDS-----SVMG-IFAIDPD---SGDILVNTVLDRE 600
Query: 505 LTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRGTK 564
T FK+N + P+L+G + V+ +D+ N ++ ++ V T V +
Sbjct: 601 QTDRYEFKVNAKDKGI-----PVLQGSTTVIVQVADK--NDNDPKFMQDVFTFYVKENLQ 653
Query: 565 GNKP 568
N P
Sbjct: 654 PNSP 657
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/62 (38%), Positives = 34/62 (54%), Gaps = 1/62 (1%)
Query: 293 EIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ-LDDPKGA 351
++ +LD+NDN P F +++ EN P G L ATD+D G NG Y+ L +P G
Sbjct: 130 QVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGG 189
Query: 352 FS 353
S
Sbjct: 190 GS 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 22/54 (40%), Positives = 32/54 (59%), Gaps = 1/54 (1%)
Query: 446 EVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
+V +LD NDN P F PS + +++ N VGT+ A D D G+NG+ Y+L
Sbjct: 130 QVIVLDINDNTPTF-PSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYEL 182
Score = 40.3 bits (90), Expect = 0.052
Identities = 21/42 (50%), Positives = 26/42 (61%), Gaps = 1/42 (2%)
Query: 1441 ATDSDIGINADIRYQILNEQAPR-FAIDPVSGTVRVVAALAR 1481
ATDSD GINAD+ Y I+ + F IDP SG V +V L +
Sbjct: 768 ATDSDDGINADLNYSIVGGNPFKLFEIDPTSGVVSLVGKLTQ 809
Score = 39.5 bits (88), Expect = 0.091
Identities = 21/46 (45%), Positives = 30/46 (65%), Gaps = 2/46 (4%)
Query: 852 SLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+LDRE++ Y+L+L RD G SS+A L ++I D NDN P F +
Sbjct: 265 ALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEK 310
Score = 37.5 bits (83), Expect = 0.37
Identities = 45/198 (22%), Positives = 73/198 (36%), Gaps = 16/198 (8%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE-LTPTGEKAFIFLI-APIGPSLTI 130
G+ + +V V + D NDN P F+ + V E L P + ++ A G + +
Sbjct: 615 GIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEM 674
Query: 131 PLTVPRGLTIFK---------DIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L + IF +FDR+ T V V G D A + V
Sbjct: 675 SLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRV--KAVDGGDPPRSATATVSLFV 732
Query: 182 LLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDR 241
+ K ++ + + + A D D G+ A L Y ++ GN
Sbjct: 733 MDENDNAPTVTLPKNISYTLLPPSSNVRTVVA---TVLATDSDDGINADLNYSIVGGNPF 789
Query: 242 KLFSLDSVNGSLFLEKEL 259
KLF +D +G + L +L
Sbjct: 790 KLFEIDPTSGVVSLVGKL 807
Score = 36.7 bits (81), Expect = 0.64
Identities = 22/59 (37%), Positives = 33/59 (55%), Gaps = 2/59 (3%)
Query: 1426 VFFERLSLNG--LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
V+F ++ G + + ATD+D G NA+I Y + + FAIDP SG + V L R+
Sbjct: 542 VYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDRE 600
Score = 34.3 bits (75), Expect = 3.4
Identities = 39/141 (27%), Positives = 60/141 (42%), Gaps = 17/141 (12%)
Query: 704 NMSSIYG--NGTGNVRF-LIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTV---- 756
N++S G G+G V F L + + + D E T +++ +DREK +M
Sbjct: 50 NVASDLGIVTGSGEVTFSLESGSEYLKIDNLTGELST--SERRIDREKLPQCQMIFDENE 107
Query: 757 -IAEFNKGVI----SGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNI 811
+F VI S +++ + + D NDN P F + EN +GT +
Sbjct: 108 CFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPT- 166
Query: 812 IKATDADEGTNALFMYTLFGE 832
ATD D G N + Y L E
Sbjct: 167 --ATDRDFGRNGIERYELLQE 185
>AB006755-1|BAA25194.1| 1069|Homo sapiens PCDH7 (BH-Pcdh)a protein.
Length = 1069
Score = 123 bits (297), Expect = 4e-27
Identities = 168/643 (26%), Positives = 266/643 (41%), Gaps = 75/643 (11%)
Query: 744 LDREKRDVYRMTV-IAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKI 802
LDRE+RD Y +T+ + + S I +V I D NDN P FE + YE + ENS
Sbjct: 266 LDREQRDSYELTLRVRDGGDPPRSSQAILRVLI--TDVNDNSPRFEKSVYEADLAENSAP 323
Query: 803 GTEIKMDNIIKATDADEGTNALFMYTLFGEGKE----MFDVDENTGVVKFIGDSLDREKK 858
GT I ++A D D G N Y +FG E + +DE +G + + +DRE+
Sbjct: 324 GTPILQ---LRAADLDVGVNGQIEY-VFGAATESVRRLLRLDETSGWLSVL-HRIDREEV 378
Query: 859 IMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGF 916
+ +++ARD G + +A +++ I DENDN P IE RI + + A
Sbjct: 379 NQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVP---SIEIRKIGRIPLKDGVANVAED 435
Query: 917 TIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYI 976
+++ D DQ EN + T++ G + ++
Sbjct: 436 VLVDTPIALVQVSDRDQ-------GENGVVTCTVV------------GDVPFQLK----- 471
Query: 977 PPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGG--NLNDNISVRVF 1034
P S D K+YF+ H EF + I A+D G +L+ S+ V
Sbjct: 472 PASDTEGDQ-NKKKYFL------HTSTPLDYEATREFNVVIVAVDSGSPSLSSKNSLIVK 524
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFE 1094
V D ND+ P+F ++ E + V ATDAD G+NA + Y + S + F
Sbjct: 525 VGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGI-FA 583
Query: 1095 ISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAF 1154
I P +G + VN LDRE D+Y V A+D G D NDN PKF
Sbjct: 584 IDPDSGDILVNTVLDREQTDRYEFKVNAKDKG-IPVLQGSTTVIVQVADKNDNDPKF--M 640
Query: 1155 DELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLI 1214
++ + E + ++ V M+ V A NA + + + N+ I N G I
Sbjct: 641 QDVFTFYVKENLQPNS----PVGMVTVMDADKGRNAEMSLYIEE--NNNIFSIENDTGTI 694
Query: 1215 LYSLPQRKNQQNL----------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYEL 1264
++ + Q G P S+TA + + V D D P IS Y L
Sbjct: 695 YSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPKNIS-YTLL 753
Query: 1265 EIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDRE 1324
NV V V ++ N + Y I+ N + F IDP +G + LV ++
Sbjct: 754 PPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPF---KLFEIDPTSGVVSLVGKLTQK 810
Query: 1325 VKDTYEVIVRA-ERQKYSRELPHMIYPVAEDVLEGMTKYDVKV 1366
+ ++V+ + + S+ +++ + + T D ++
Sbjct: 811 HYGLHRLVVQVNDSGQPSQSTTTVVHVFVNESVSNATAIDSQI 853
Score = 95.1 bits (226), Expect = 2e-18
Identities = 122/470 (25%), Positives = 205/470 (43%), Gaps = 46/470 (9%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
+ V + D NDN+P F S +YE + N+ GT I +++A D D+G NG + Y +
Sbjct: 294 LRVLITDVNDNSPRFEKS-VYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATE 352
Query: 505 LTITSPFKINPNTGTVSVAESPILEGRHAL--FVEASDQPANPSERRYSLAVVTIEVTRG 562
++ +++ +G +SV E + L V A D+ P + A V + + +
Sbjct: 353 -SVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDK---ATVVLNI-KD 407
Query: 563 TKGNKP--DIPDFMGAPYEFWVGS---NVGIGTSVGQIRVNDAFE-QNDVSYDLLHGYEE 616
N P +I P + V + +V + T + ++V+D + +N V + G
Sbjct: 408 ENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVG--- 464
Query: 617 GVPFAVEERSGVITVVDDLSRY---NRPMYDFEA--------VALQENA-NLSIVTNATV 664
VPF ++ S + + + P+ D+EA VA+ + +LS + V
Sbjct: 465 DVPFQLKPASDTEGDQNKKKYFLHTSTPL-DYEATREFNVVIVAVDSGSPSLSSKNSLIV 523
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
V D ND + G ++ + N G + + T+ S G N +
Sbjct: 524 KVGDTNDNPPMF--GQSVVEVYFPENNIPGERVATVLATDADS--GK---NAEIAYSLDS 576
Query: 725 DVTDDIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDN 783
V AI D G I LDRE+ D Y V A+ +KG+ G V + + D+NDN
Sbjct: 577 SVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAK-DKGIPVLQGSTTVIVQVADKNDN 635
Query: 784 PPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENT 843
P F + ++ EN + + + M + DAD+G NA M E +F ++ +T
Sbjct: 636 DPKFMQDVFTFYVKENLQPNSPVGM---VTVMDADKGRNA-EMSLYIEENNNIFSIENDT 691
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKP 891
G + + S DRE + Y + A D G S+ A + + + DENDN P
Sbjct: 692 GTI-YSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAP 740
Score = 81.0 bits (191), Expect = 3e-14
Identities = 111/413 (26%), Positives = 173/413 (41%), Gaps = 56/413 (13%)
Query: 996 ERHGHVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYN 1051
E+ +IV +L E + L + DGG+ + +RV + DVND+ P F+K+ Y
Sbjct: 255 EKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYE 314
Query: 1052 FNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP--FEISPLTGVLSVNGELD 1109
++ E + ++ A D D G N + Y + + + +G LSV +D
Sbjct: 315 ADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRID 374
Query: 1110 RETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELS 1169
RE ++ TV+ARD G D NDN P + + + P D ++
Sbjct: 375 REEVNQLRFTVMARDRG-QPPKTDKATVVLNIKDENDNVP---SIEIRKIGRIPLKDGVA 430
Query: 1170 NHNFESVMMIPVYKATIE-----ENAPIGTTVAKVF------ANDTDFIGNGNGLILY-S 1217
N + ++ P+ + EN + TV A+DT+ N L+ S
Sbjct: 431 NVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTS 490
Query: 1218 LP---QRKNQQNL-------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIE 1267
P + + N+ G PSLSS L+V V D D + P+F E+
Sbjct: 491 TPLDYEATREFNVVIVAVDSGSPSLSSKNSLIVKVGDTND-----NPPMFGQSVVEVYFP 545
Query: 1268 ENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKD 1327
EN N P E V+ L ++ K I D+ + F IDP +G + + DRE D
Sbjct: 546 EN-NIPGERVATVLATDADSGK-NAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDREQTD 603
Query: 1328 TYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF 1380
YE V A+ + +P VL+G T V+V++ D NDN PKF
Sbjct: 604 RYEFKVNAK----DKGIP---------VLQGST----TVIVQVADKNDNDPKF 639
Score = 81.0 bits (191), Expect = 3e-14
Identities = 49/160 (30%), Positives = 81/160 (50%), Gaps = 7/160 (4%)
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
+ T PLD E + + ++A + G S + + + + D NDNPP+F + E +
Sbjct: 487 LHTSTPLDYEATREFNVVIVA-VDSGSPSLSSKNSLIVKVGDTNDNPPMFGQSVVEVYFP 545
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREK 857
EN+ G + + ATDAD G NA Y+L +F +D ++G + + LDRE+
Sbjct: 546 ENNIPGERVA---TVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDI-LVNTVLDREQ 601
Query: 858 KIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ 895
Y+ + A+D G L +I+ + D+NDN P+F Q
Sbjct: 602 TDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQ 641
Score = 80.2 bits (189), Expect = 5e-14
Identities = 106/464 (22%), Positives = 197/464 (42%), Gaps = 52/464 (11%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAK-------VGTVIGKVKAVDPDLGQNGMVLY 497
V + + D NDN P + +K V T I V+ D D G+NG+V
Sbjct: 401 VVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVV-- 458
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTI 557
T + PF++ P + T + + F+ S + R +++ +V +
Sbjct: 459 ----TCTVVGDVPFQLKPASDTEGD------QNKKKYFLHTSTPLDYEATREFNVVIVAV 508
Query: 558 EV---TRGTK-------GNKPDIPDFMG-APYEFWVGSNVGIGTSVGQIRVNDAF--EQN 604
+ + +K G+ D P G + E + N G V + DA +
Sbjct: 509 DSGSPSLSSKNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNA 568
Query: 605 DVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
+++Y L G+ FA++ SG I V L R Y+F+ A ++ + ++ +T
Sbjct: 569 EIAYSL-DSSVMGI-FAIDPDSGDILVNTVLDREQTDRYEFKVNA--KDKGIPVLQGSTT 624
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
+V V D+ K F+VKEN + +G + T M + G ++ N
Sbjct: 625 VIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMV--TVMDADKGRNAEMSLYIEENN 682
Query: 724 QDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDN 783
+ + + GTI++ DRE + Y V A + G + V++++ DENDN
Sbjct: 683 NIFSIE---NDTGTIYSTMSFDREHQTTYTFRVKA-VDGGDPPRSATATVSLFVMDENDN 738
Query: 784 PPVF---EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGK-EMFDV 839
P ++ +Y + +S + T + + ATD+D+G NA Y++ G ++F++
Sbjct: 739 APTVTLPKNISYT-LLPPSSNVRTVVAT---VLATDSDDGINADLNYSIVGGNPFKLFEI 794
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMI 883
D +GVV +G L ++ +++L + D+G S ++ +
Sbjct: 795 DPTSGVVSLVG-KLTQKHYGLHRLVVQVNDSGQPSQSTTTVVHV 837
Score = 71.7 bits (168), Expect = 2e-11
Identities = 103/448 (22%), Positives = 184/448 (41%), Gaps = 58/448 (12%)
Query: 268 QANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQ 327
Q +++ L ++ +P +++QA + + + D+NDN P FE Y + EN G +LQ
Sbjct: 270 QRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQ 329
Query: 328 VMATDKDQGENGEFTY----QLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
+ A D D G NG+ Y + + +D SGWL+V ++ +DRE + LR V A
Sbjct: 330 LRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHR--IDREEVNQLRFTVMA 387
Query: 384 KETNPSVVGTFADSQRIAKWRRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLMSFV 443
++ R QP +T +K T V + + +N+ + + + +
Sbjct: 388 RD------------------RGQPPKT----DKATVVL--NIKDENDNVPSIEIRKIGRI 423
Query: 444 NVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVG----TVIGKV----KAVDPDLGQNGMV 495
++ + + ++ V P L + S + + G TV+G V K G
Sbjct: 424 PLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKK 483
Query: 496 LYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVV 555
Y L ++ L + + N V + SP L +++L V+ D NP S+ V
Sbjct: 484 KYFLHTSTPLDYEATREFNVVIVAVD-SGSPSLSSKNSLIVKVGDTNDNPPMFGQSVVEV 542
Query: 556 -----TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNV----GIGTSVGQIRVNDAF--EQN 604
I R D A + + S+V I G I VN EQ
Sbjct: 543 YFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDREQT 602
Query: 605 DVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
D ++ ++G+P + ++ V D + M D ++EN + N+ V
Sbjct: 603 DRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKEN----LQPNSPV 658
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENS 692
+V V D KG ++ + +++EN+
Sbjct: 659 GMVTVMDAD----KGRNAEMSLYIEENN 682
Score = 69.7 bits (163), Expect = 7e-11
Identities = 47/133 (35%), Positives = 65/133 (48%), Gaps = 6/133 (4%)
Query: 254 FLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNI 313
FL LD E + N ++ V + +P +++ + +++ D NDN P F +
Sbjct: 486 FLHTSTPLDYEATREFNVVIVAVDSG---SPSLSSKNSLIVKVGDTNDNPPMFGQSVVEV 542
Query: 314 SIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDP-KGAFSIDPRSGWLTVRNQTVLDRE 372
EN G V V+ATD D G+N E Y LD G F+IDP SG + V TVLDRE
Sbjct: 543 YFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILV--NTVLDRE 600
Query: 373 AHSSLRMKVYAKE 385
KV AK+
Sbjct: 601 QTDRYEFKVNAKD 613
Score = 66.5 bits (155), Expect = 7e-10
Identities = 45/164 (27%), Positives = 76/164 (46%), Gaps = 8/164 (4%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D G A + Y L S + +F++D +G + + LD + Q + + +V A
Sbjct: 559 ATDADSGKNAEIAYSLDS-SVMGIFAIDPDSGDILVNTVLDRE-----QTDRYEFKVNAK 612
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
P+ V +++ D NDN P+F D + + ENL V V D D+G N
Sbjct: 613 DKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNA 672
Query: 340 EFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
E + +++ FSI+ +G T+ + DRE ++ +V A
Sbjct: 673 EMSLYIEENNNIFSIENDTG--TIYSTMSFDREHQTTYTFRVKA 714
Score = 66.1 bits (154), Expect = 9e-10
Identities = 78/308 (25%), Positives = 127/308 (41%), Gaps = 28/308 (9%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
+V + +G +S+ S+ V + D NDN P+F + V E GE+ L
Sbjct: 505 IVAVDSGSPSLSSKNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADS 564
Query: 127 SLTIPLTVPRGLTIFKDIRAFDRDK----PNT----PNSDVHYSIVSGNDDGHFALESSH 178
+ ++ I A D D NT +D + V+ D G L+ S
Sbjct: 565 GKNAEIAYSLDSSVM-GIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGS- 622
Query: 179 KPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFP-EPIHAID-QDLGVGATLRYELI 236
++ +V D + D +F + KE L P P+ + D G L
Sbjct: 623 --TTVIVQVADKNDNDPKFMQDVFTF---YVKENLQPNSPVGMVTVMDADKGRNAEMSLY 677
Query: 237 SGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
+ +FS+++ G+++ + D EH T+ +V+A +P ++A A V + +
Sbjct: 678 IEENNNIFSIENDTGTIY--STMSFDREHQ---TTYTFRVKAVDGGDPPRSATATVSLFV 732
Query: 297 LDLNDNLPEFEVDFYNISIVENLPNG---FSVLQVMATDKDQGENGEFTYQL--DDPKGA 351
+D NDN P + NIS P+ V V+ATD D G N + Y + +P
Sbjct: 733 MDENDNAPTVTLP-KNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKL 791
Query: 352 FSIDPRSG 359
F IDP SG
Sbjct: 792 FEIDPTSG 799
Score = 59.7 bits (138), Expect = 8e-08
Identities = 63/248 (25%), Positives = 109/248 (43%), Gaps = 22/248 (8%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLI-AN 722
V + DVND K + + ENSA I + + G + ++ A
Sbjct: 296 VLITDVNDNSPRFEKSVYEA---DLAENSAPGT--PILQLRAADLDVGVNGQIEYVFGAA 350
Query: 723 QQDVTDDIAIAE-DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
+ V + + E G + +DRE+ + R TV+A ++G V + I+DEN
Sbjct: 351 TESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMAR-DRGQPPKTDKATVVLNIKDEN 409
Query: 782 DNPPVFEHATYEGFIMEN--SKIGTEIKMDN---IIKATDADEGTNALFMYTLFGEG--- 833
DN P E +++ + + ++ +D +++ +D D+G N + T+ G+
Sbjct: 410 DNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQ 469
Query: 834 -KEMFDVDENTGVVKFI---GDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDEN 887
K D + + K+ LD E + + +VA D+G LSS+ LI+ +GD N
Sbjct: 470 LKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSKNSLIVKVGDTN 529
Query: 888 DNKPEFNQ 895
DN P F Q
Sbjct: 530 DNPPMFGQ 537
Score = 52.4 bits (120), Expect = 1e-05
Identities = 75/308 (24%), Positives = 134/308 (43%), Gaps = 28/308 (9%)
Query: 364 RNQTVLDREAHSSLRMKVYAKETNPSVVGTFADSQRIAKWRRQPLETNAPLEKT-TYVFP 422
R TVL +A S ++ A + SV+G FA + N L++ T +
Sbjct: 553 RVATVLATDADSGKNAEI-AYSLDSSVMGIFAIDPDSGD-----ILVNTVLDREQTDRYE 606
Query: 423 DKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKV 482
KV K + I L V V + D NDN+P F+ +++ F +K N + + +G V
Sbjct: 607 FKVNAKDKGIPV----LQGSTTVIVQVADKNDNDPKFM-QDVFTFYVKENLQPNSPVGMV 661
Query: 483 KAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASD 540
+D D G+N + ++ +N+ F I +TGT+ S E + + V+A D
Sbjct: 662 TVMDADKGRNAEMSLYIEENNNI-----FSIENDTGTIYSTMSFDREHQTTYTFRVKAVD 716
Query: 541 QPANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA 600
P R + A V++ V N P + Y S+ + T V + D+
Sbjct: 717 GGDPP---RSATATVSLFV-MDENDNAPTVTLPKNISYTLLPPSS-NVRTVVATVLATDS 771
Query: 601 FE--QNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSI 658
+ D++Y ++ G + F ++ SGV+++V L++ + ++ V + ++ S
Sbjct: 772 DDGINADLNYSIVGGNPFKL-FEIDPTSGVVSLVGKLTQKHYGLHRL-VVQVNDSGQPSQ 829
Query: 659 VTNATVHV 666
T VHV
Sbjct: 830 STTTVVHV 837
Score = 52.0 bits (119), Expect = 2e-05
Identities = 82/364 (22%), Positives = 145/364 (39%), Gaps = 49/364 (13%)
Query: 218 IHAIDQDLGVGATLRYELISGND--RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A D D+GV + Y + + R+L LD +G L + +D + + N
Sbjct: 330 LRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDRE-----EVNQLRFT 384
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN--------ISIVENLPNGFSVLQ 327
V A P KT +A V + + D NDN+P E+ ++ E++ +
Sbjct: 385 VMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIAL 444
Query: 328 VMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA-K 384
V +D+DQGENG T + D P F + P S T +Q H+S + A +
Sbjct: 445 VQVSDRDQGENGVVTCTVVGDVP---FQLKPASD--TEGDQNKKKYFLHTSTPLDYEATR 499
Query: 385 ETNPSVVGTFADSQRIAKWRRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLMSFVN 444
E N +V + S ++ ++ T P G + + + +
Sbjct: 500 EFNVVIVAVDSGSPSLSSKNSLIVKVG-----DTNDNPPMFGQSVVEVYFPENNIPGERV 554
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V DA+ + +S+ S +V+G + A+DPD +G +L +
Sbjct: 555 ATVLATDADSGKNAEI-----AYSLDS-----SVMG-IFAIDPD---SGDILVNTVLDRE 600
Query: 505 LTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRGTK 564
T FK+N + P+L+G + V+ +D+ N ++ ++ V T V +
Sbjct: 601 QTDRYEFKVNAKDKGI-----PVLQGSTTVIVQVADK--NDNDPKFMQDVFTFYVKENLQ 653
Query: 565 GNKP 568
N P
Sbjct: 654 PNSP 657
Score = 45.2 bits (102), Expect = 0.002
Identities = 24/62 (38%), Positives = 34/62 (54%), Gaps = 1/62 (1%)
Query: 293 EIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ-LDDPKGA 351
++ +LD+NDN P F +++ EN P G L ATD+D G NG Y+ L +P G
Sbjct: 130 QVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGG 189
Query: 352 FS 353
S
Sbjct: 190 GS 191
Score = 44.0 bits (99), Expect = 0.004
Identities = 22/54 (40%), Positives = 32/54 (59%), Gaps = 1/54 (1%)
Query: 446 EVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
+V +LD NDN P F PS + +++ N VGT+ A D D G+NG+ Y+L
Sbjct: 130 QVIVLDINDNTPTF-PSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYEL 182
Score = 40.3 bits (90), Expect = 0.052
Identities = 21/42 (50%), Positives = 26/42 (61%), Gaps = 1/42 (2%)
Query: 1441 ATDSDIGINADIRYQILNEQAPR-FAIDPVSGTVRVVAALAR 1481
ATDSD GINAD+ Y I+ + F IDP SG V +V L +
Sbjct: 768 ATDSDDGINADLNYSIVGGNPFKLFEIDPTSGVVSLVGKLTQ 809
Score = 39.5 bits (88), Expect = 0.091
Identities = 21/46 (45%), Positives = 30/46 (65%), Gaps = 2/46 (4%)
Query: 852 SLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+LDRE++ Y+L+L RD G SS+A L ++I D NDN P F +
Sbjct: 265 ALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEK 310
Score = 37.5 bits (83), Expect = 0.37
Identities = 45/198 (22%), Positives = 73/198 (36%), Gaps = 16/198 (8%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE-LTPTGEKAFIFLI-APIGPSLTI 130
G+ + +V V + D NDN P F+ + V E L P + ++ A G + +
Sbjct: 615 GIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEM 674
Query: 131 PLTVPRGLTIFK---------DIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
L + IF +FDR+ T V V G D A + V
Sbjct: 675 SLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRV--KAVDGGDPPRSATATVSLFV 732
Query: 182 LLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDR 241
+ K ++ + + + A D D G+ A L Y ++ GN
Sbjct: 733 MDENDNAPTVTLPKNISYTLLPPSSNVRTVVA---TVLATDSDDGINADLNYSIVGGNPF 789
Query: 242 KLFSLDSVNGSLFLEKEL 259
KLF +D +G + L +L
Sbjct: 790 KLFEIDPTSGVVSLVGKL 807
Score = 36.7 bits (81), Expect = 0.64
Identities = 22/59 (37%), Positives = 33/59 (55%), Gaps = 2/59 (3%)
Query: 1426 VFFERLSLNG--LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
V+F ++ G + + ATD+D G NA+I Y + + FAIDP SG + V L R+
Sbjct: 542 VYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDRE 600
Score = 34.3 bits (75), Expect = 3.4
Identities = 39/141 (27%), Positives = 60/141 (42%), Gaps = 17/141 (12%)
Query: 704 NMSSIYG--NGTGNVRF-LIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTV---- 756
N++S G G+G V F L + + + D E T +++ +DREK +M
Sbjct: 50 NVASDLGIVTGSGEVTFSLESGSEYLKIDNLTGELST--SERRIDREKLPQCQMIFDENE 107
Query: 757 -IAEFNKGVI----SGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNI 811
+F VI S +++ + + D NDN P F + EN +GT +
Sbjct: 108 CFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPT- 166
Query: 812 IKATDADEGTNALFMYTLFGE 832
ATD D G N + Y L E
Sbjct: 167 --ATDRDFGRNGIERYELLQE 185
>AB075518-1|BAE45762.1| 656|Homo sapiens putative protein product
of Nbla00548 protein.
Length = 656
Score = 122 bits (294), Expect = 1e-26
Identities = 123/439 (28%), Positives = 199/439 (45%), Gaps = 40/439 (9%)
Query: 444 NVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTS 503
+V + + D NDN P F ++ Y ++G+ + +V A DPD G NG V Y ++ S
Sbjct: 149 DVTIFVTDINDNAPRFSRTSYY-LDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQS 207
Query: 504 NLTITSPFKINPNTGTVSVAE----------SPILEGRHALFVEASDQPANPSERRYSLA 553
F+IN TG + + S + RH+ V +SD+ PS S
Sbjct: 208 EY-----FRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDR-GKPS--LISET 259
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE---QNDVSYDL 610
VTI + + + P F+ + Y V NV +GT + ++ D + ++V Y +
Sbjct: 260 TVTINIV----DSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFI 315
Query: 611 LHGYEEGVPFAVEERSGVITVVDDL-SRYNRPMYDFEAVALQENANLSIVTNATVHVVDV 669
+ G F ++ +G I+V L S N+ F V ++ N + + ATVH+ V
Sbjct: 316 SNDNHLG-KFKLDNDTGWISVASSLISDLNQNF--FITVTAKDKGNPPLSSQATVHIT-V 371
Query: 670 NDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
+E + + S + + E+ + +I + NG N++ +
Sbjct: 372 TEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGI--- 428
Query: 730 IAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
AI + G + K LD E + MT+ A + G ++ G VT+ + D NDN PVF
Sbjct: 429 FAINSSTGILTLAKALDYELCQKHEMTISA-IDGGWVARTGYCSVTVNVIDVNDNSPVFL 487
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
Y ++EN+ GT + N ATDAD GTNA+ YT+ ++F +D NTGV+
Sbjct: 488 SDDYFPTVLENAPSGTTVIHLN---ATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVITT 544
Query: 849 IGDSLDREKKIMYKLSLVA 867
G LD E K Y L++ A
Sbjct: 545 QG-FLDFETKQSYHLTVKA 562
Score = 117 bits (281), Expect = 4e-25
Identities = 166/635 (26%), Positives = 267/635 (42%), Gaps = 89/635 (14%)
Query: 504 NLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIEVTR 561
N + + F IN TG + E + L +++SD+ +PS+ ++ I
Sbjct: 1 NGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDK-GSPSQSTSVKVMINI---L 56
Query: 562 GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGY---EEGV 618
N P A V N +G +V ++ +D D+ + + Y + +
Sbjct: 57 DENDNAPRFSQIFSAH----VPENSPLGYTVTRVTTSD----EDIGINAISRYSIMDASL 108
Query: 619 PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLK 678
PF + +G I + L+R + Y A ++ ++ T+ T+ V D+ND +
Sbjct: 109 PFTINPSTGDIVISRPLNREDTDRYRIRVSA--HDSGWTVSTDVTIFVTDINDNAPRFSR 166
Query: 679 GAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTI 738
++ + E G+ + Q+F T+ G V + I +Q + A G I
Sbjct: 167 TSYYLDCPELTE--IGSKVTQVFATDPDE---GSNGQVFYFIKSQSEYFR--INATTGEI 219
Query: 739 FTQKPLDREKR------DVYRMT-VIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
F ++ L + ++ R + ++ ++G S VTI I D NDN P F +
Sbjct: 220 FNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSK 279
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD 851
Y + +N K+GT K+ + D D G N+ Y + D + G K
Sbjct: 280 YFTPVTKNVKVGT--KLIRVTAIDDKDFGLNSEVEYFISN--------DNHLGKFK---- 325
Query: 852 SLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
LD DTG +S + LI D N N I +K + +
Sbjct: 326 -LDN-------------DTGWISVASSLI---SDLNQNF----FITVTAKDKGNPPLSSQ 364
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
T T+ E +N + Q IPE+ IG+ + ++A D D+ +NG I+Y +
Sbjct: 365 ATVHITVTE---ENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSIS 421
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNL--ND 1027
S + F IN G + +A++L E + + ISA+DGG +
Sbjct: 422 SG-------------NEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTG 468
Query: 1028 NISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
SV V V DVND+ PVF Y V E + + ++ATDAD G NA + Y +Q S
Sbjct: 469 YCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSS 528
Query: 1088 DTDLPFEISPLTGVLSVNGELDRETEDKYILTVVA 1122
D+DL F I P TGV++ G LD ET+ Y LTV A
Sbjct: 529 DSDL-FVIDPNTGVITTQGFLDFETKQSYHLTVKA 562
Score = 113 bits (273), Expect = 3e-24
Identities = 117/424 (27%), Positives = 185/424 (43%), Gaps = 28/424 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAV-DPDLGQNGMVLY 497
L+S V + ++D+NDN P F+ S Y + N KVGT + +V A+ D D G N V Y
Sbjct: 255 LISETTVTINIVDSNDNAPQFLKSK-YFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEY 313
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVE-ASDQPANPSERRYSLAVVT 556
+ ++L FK++ +TG +SVA S I + F+ + NP S A V
Sbjct: 314 FISNDNHL---GKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPP--LSSQATVH 368
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQI--RVNDAFEQNDVSYDLLHGY 614
I VT P+F + + + IG+ V + R DA + Y + G
Sbjct: 369 ITVTE----ENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGN 424
Query: 615 EEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQEN-ANLSIVTNATVHVVDVNDER 673
EEG+ FA+ +G++T+ L ++ A+ + + TV+V+DVND
Sbjct: 425 EEGI-FAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNS 483
Query: 674 GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIA 733
V L + P + EN+ + H N + +GT V D +
Sbjct: 484 PVFLSDDYFPTVL---ENAPSGT--TVIHLNATDA-DSGTNAVIAYTVQSSDSDLFVIDP 537
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
G I TQ LD E + Y +TV A FN V I ++ N+ P F Y
Sbjct: 538 NTGVITTQGFLDFETKQSYHLTVKA-FNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYY 596
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG-KEMFDVDENTGVVKFIGDS 852
I E + GT + + A+D D GT+ Y +FG K+ F +++ TG + ++
Sbjct: 597 FEISEAAPKGTIV---GEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQI-YVSGI 652
Query: 853 LDRE 856
LD++
Sbjct: 653 LDQK 656
Score = 87.0 bits (206), Expect = 5e-16
Identities = 83/312 (26%), Positives = 134/312 (42%), Gaps = 19/312 (6%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF 141
+VT+ I D NDN P FL + Y V + G K I + A + V ++
Sbjct: 260 TVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTK-LIRVTAIDDKDFGLNSEVEYFISND 318
Query: 142 KDIRAFDRDKPNTPNSDVHYSIVSGNDDGHF----ALESSHKPV----LLLRKVLDYDAG 193
+ F D +T V S++S + F A + + P+ + V + +
Sbjct: 319 NHLGKFKLDN-DTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYH 377
Query: 194 DKEF-QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGS 252
EF Q + A+ H + A D+D + ++Y + SGN+ +F+++S G
Sbjct: 378 TPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGI 437
Query: 253 LFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN 312
L L K LD + + + A +T V + ++D+NDN P F D Y
Sbjct: 438 LTLAKALDYEL-----CQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYF 492
Query: 313 ISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSGWLTVRNQTVLDR 371
+++EN P+G +V+ + ATD D G N Y + F IDP +G +T Q LD
Sbjct: 493 PTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVIT--TQGFLDF 550
Query: 372 EAHSSLRMKVYA 383
E S + V A
Sbjct: 551 ETKQSYHLTVKA 562
Score = 83.4 bits (197), Expect = 6e-15
Identities = 90/362 (24%), Positives = 151/362 (41%), Gaps = 32/362 (8%)
Query: 992 FVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVK--DVNDHFPVFKK 1047
F IN G + R L E S + L I + D G+ + + SV+V + D ND+ P F +
Sbjct: 8 FSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQ 67
Query: 1048 TWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGE 1107
++ +V E + +V +D D G NA Y I D LPF I+P TG + ++
Sbjct: 68 I-FSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIM--DASLPFTINPSTGDIVISRP 124
Query: 1108 LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF----YAFD--ELLEWK 1161
L+RE D+Y + V A D+G D+NDN+P+F Y D EL E
Sbjct: 125 LNREDTDRYRIRVSAHDSG----WTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIG 180
Query: 1162 HPEADELSNHNFE-SVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQ 1220
+ E S + + + E I T ++F N G ++ +
Sbjct: 181 SKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINR 240
Query: 1221 RK---NQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELV 1277
+ G PSL S + + + D D + P F+ Y + +NV +L+
Sbjct: 241 HSFIVTSSDRGKPSLISETTVTINIVDSND-----NAPQFLKSKYFTPVTKNVKVGTKLI 295
Query: 1278 SLNLTEHYE---NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVR 1334
+ + + N ++ Y+I N+N F +D G + + S ++ + + V
Sbjct: 296 RVTAIDDKDFGLNSEVEYFISNDNHLG---KFKLDNDTGWISVASSLISDLNQNFFITVT 352
Query: 1335 AE 1336
A+
Sbjct: 353 AK 354
Score = 83.0 bits (196), Expect = 7e-15
Identities = 110/468 (23%), Positives = 191/468 (40%), Gaps = 47/468 (10%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + +LD NDN P F S ++ + N+ +G + +V D D+G N + Y +
Sbjct: 49 VKVMINILDENDNAPRF--SQIFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDA 106
Query: 503 SNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIEVT 560
S PF INP+TG + ++ E R+ + V A D S V+ +VT
Sbjct: 107 S-----LPFTINPSTGDIVISRPLNREDTDRYRIRVSAHD----------SGWTVSTDVT 151
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE-QNDVSYDLLHGYEEGVP 619
+ P F Y IG+ V Q+ D E N + + E
Sbjct: 152 IFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSE--Y 209
Query: 620 FAVEERSGVI--------TVVDDLSRYNRPMYDFEAVALQENANLSIV--TNATVHVVDV 669
F + +G I V S N + F V + S++ T T+++VD
Sbjct: 210 FRINATTGEIFNKQILKYQNVTGFSNVNINRHSF-IVTSSDRGKPSLISETTVTINIVDS 268
Query: 670 NDERGVLLKGAH-SPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTD 728
ND LK + +P+ +VK + + I + V + I+N +
Sbjct: 269 NDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGL-----NSEVEYFISNDNHLGK 323
Query: 729 DIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ G I L + + +TV A+ +KG + V I + +EN + P F
Sbjct: 324 FKLDNDTGWISVASSLISDLNQNFFITVTAK-DKGNPPLSSQATVHITVTEENYHTPEFS 382
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKE-MFDVDENTGVVK 847
+ I E+ IG+ ++ + A D D N L Y++ +E +F ++ +TG++
Sbjct: 383 QSHMSATIPESHSIGSIVR---TVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILT 439
Query: 848 FIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIGDENDNKPEF 893
+ +LD E +++++ A D G + + + + + D NDN P F
Sbjct: 440 -LAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVF 486
Score = 82.6 bits (195), Expect = 1e-14
Identities = 77/284 (27%), Positives = 124/284 (43%), Gaps = 47/284 (16%)
Query: 940 IPENIPIGTTIIKLNALD-LDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERH 998
+ +N+ +GT +I++ A+D D GLN ++ Y +++ ++ KL D
Sbjct: 284 VTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDT------------- 330
Query: 999 GHVIVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNV 1054
G + VA SL + F + ++A D GN L+ +V + V + N H P F ++ + +
Sbjct: 331 GWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATI 390
Query: 1055 EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETED 1114
E+ ++ V A D D N + Y I + + F I+ TG+L++ LD E
Sbjct: 391 PESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQ 450
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFE 1174
K+ +T+ A D G DVNDNSP F + D
Sbjct: 451 KHEMTISAIDGG-WVARTGYCSVTVNVIDVNDNSPVFLSDD------------------- 490
Query: 1175 SVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSL 1218
Y T+ ENAP GTTV + A D D N +I Y++
Sbjct: 491 -------YFPTVLENAPSGTTVIHLNATDAD--SGTNAVIAYTV 525
Score = 73.7 bits (173), Expect = 5e-12
Identities = 94/409 (22%), Positives = 170/409 (41%), Gaps = 34/409 (8%)
Query: 941 PENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGH 1000
PE IG+ + ++ A D D G NGQ+ Y S+ +++A E+ ++ ++
Sbjct: 174 PELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEY--FRINATTGEIFNKQILKYQN-- 229
Query: 1001 VIVARSLPPESEFRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQ 1058
+ S + +++ D G +L +V + + D ND+ P F K+ Y V +
Sbjct: 230 -VTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNV 288
Query: 1059 YTRRVLGKVDA-TDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYI 1117
L +V A D DFG N+ + YFI + F++ TG +SV L + +
Sbjct: 289 KVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFF 348
Query: 1118 LTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVM 1177
+TV A+D G + N ++P+F H A +H+ S++
Sbjct: 349 ITVTAKDKGNPPLSSQATVHITVTEE-NYHTPEF-------SQSHMSATIPESHSIGSIV 400
Query: 1178 -MIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLIL------YSLPQRKNQQNLGLP 1230
+ N I +++ I + G++ Y L Q+ +
Sbjct: 401 RTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAID 460
Query: 1231 S--LSSTAILMVTVADVPDEVEMSD-KPVFISRYYELEIEENVNAPVELVSLNLTEHYEN 1287
++ T VTV + ++++D PVF+S Y + EN + ++ LN T+
Sbjct: 461 GGWVARTGYCSVTV----NVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSG 516
Query: 1288 FK-MRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
+ Y + +D+D+ FVIDP G + D E K +Y + V+A
Sbjct: 517 TNAVIAYTVQSSDSDL---FVIDPNTGVITTQGFLDFETKQSYHLTVKA 562
Score = 73.3 bits (172), Expect = 6e-12
Identities = 85/333 (25%), Positives = 139/333 (41%), Gaps = 26/333 (7%)
Query: 68 VRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF-IFLIAPIGP 126
+R+ A + + VT+++ D+NDN P F T Y++ ELT G K +F P
Sbjct: 135 IRVSAHDSGWTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEG 194
Query: 127 SLTIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSG----NDDGH-FALESSH--K 179
S + + + I A + N + Y V+G N + H F + SS K
Sbjct: 195 SNGQVFYFIKSQSEYFRINATTGEIFN--KQILKYQNVTGFSNVNINRHSFIVTSSDRGK 252
Query: 180 PVLLLRKVLD---YDAGDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGATLR 232
P L+ + D+ D Q + + K + + + D+D G+ + +
Sbjct: 253 PSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVE 312
Query: 233 YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV 292
Y + + N F LD+ G + + L D N F + V A NP ++QA V
Sbjct: 313 YFISNDNHLGKFKLDNDTGWISVASSLISDLNQN-----FFITVTAKDKGNPPLSSQATV 367
Query: 293 EIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD--DPKG 350
I + + N + PEF + +I E+ G V V A D+D NG Y + + +G
Sbjct: 368 HITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEG 427
Query: 351 AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
F+I+ +G LT+ LD E M + A
Sbjct: 428 IFAINSSTGILTLAK--ALDYELCQKHEMTISA 458
Score = 70.1 bits (164), Expect = 6e-11
Identities = 43/154 (27%), Positives = 80/154 (51%), Gaps = 8/154 (5%)
Query: 237 SGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
+GN FS++ G + + LD + + + +VL +++S +P ++ +V I +
Sbjct: 1 NGNMENSFSINHATGEIRSVRPLDRE-----KVSHYVLTIKSSDKGSPSQSTSVKVMINI 55
Query: 297 LDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDP 356
LD NDN P F ++ + EN P G++V +V +D+D G N Y + D F+I+P
Sbjct: 56 LDENDNAPRFS-QIFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDASLPFTINP 114
Query: 357 RSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSV 390
+G + + L+RE R++V A ++ +V
Sbjct: 115 STGDIVISRP--LNREDTDRYRIRVSAHDSGWTV 146
Score = 68.1 bits (159), Expect = 2e-10
Identities = 57/194 (29%), Positives = 90/194 (46%), Gaps = 25/194 (12%)
Query: 929 LDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
+DV+ P+FL + EN P GTT+I LNA D DSG N I Y S
Sbjct: 477 IDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSS-------- 528
Query: 982 SADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGGNLN--DNISVRVFVKD 1037
+D FVI+ G + L E++ + L + A + + +V + +K
Sbjct: 529 DSDL------FVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKG 582
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISP 1097
N++ P F Y F + EA ++G+V A+D D G + + Y I + F+I+
Sbjct: 583 TNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINK 642
Query: 1098 LTGVLSVNGELDRE 1111
TG + V+G LD++
Sbjct: 643 KTGQIYVSGILDQK 656
Score = 61.3 bits (142), Expect = 3e-08
Identities = 44/157 (28%), Positives = 77/157 (49%), Gaps = 10/157 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
++A D D G A + Y + +D LF +D G + + LD + + + + L V+
Sbjct: 508 LNATDADSGTNAVIAYT-VQSSDSDLFVIDPNTGVITTQGFLDFETKQS-----YHLTVK 561
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A + + + + A V I+L N+ +P F Y I E P G V +V A+D+D G
Sbjct: 562 AFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGT 621
Query: 338 NGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDRE 372
+GE Y + + K F I+ ++G + V +LD++
Sbjct: 622 DGEVHYLIFGNSRKKGFQINKKTGQIYVSG--ILDQK 656
Score = 56.8 bits (131), Expect = 6e-07
Identities = 74/324 (22%), Positives = 131/324 (40%), Gaps = 30/324 (9%)
Query: 142 KDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVI 201
+ +R DR+K + HY + + D +S+ V++ +LD + F +
Sbjct: 18 RSVRPLDREKVS------HYVLTIKSSDKGSPSQSTSVKVMI--NILDENDNAPRFSQIF 69
Query: 202 MASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDL 261
A + D+D+G+ A RY ++ + F+++ G + + + L+
Sbjct: 70 SAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDAS--LPFTINPSTGDIVISRPLNR 127
Query: 262 DAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN 321
+ + + ++V A T V I + D+NDN P F Y + E
Sbjct: 128 E-----DTDRYRIRVSAHDSG---WTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEI 179
Query: 322 GFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDRE---AHSSLR 378
G V QV ATD D+G NG+ Y + F I+ +G + N+ +L + S++
Sbjct: 180 GSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINATTG--EIFNKQILKYQNVTGFSNVN 237
Query: 379 MKVYAKETNPSVVG-TFADSQRIAKWRRQPLETNAP-LEKTTYVFP----DKVGTKTENI 432
+ ++ S G S+ NAP K+ Y P KVGTK +
Sbjct: 238 INRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRV 297
Query: 433 EYYDEQLMSFVNVEVTLLDANDNN 456
D++ +N EV +NDN+
Sbjct: 298 TAIDDKDFG-LNSEVEYFISNDNH 320
Score = 53.2 bits (122), Expect = 7e-06
Identities = 34/88 (38%), Positives = 46/88 (52%), Gaps = 4/88 (4%)
Query: 436 DEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMV 495
DE+ SF V + L N+ P FV S LY F + A GT++G+V A D DLG +G V
Sbjct: 567 DEERCSFATVNIQLKGTNEYVPRFV-SKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEV 625
Query: 496 LYDLQRTSNLTITSPFKINPNTGTVSVA 523
Y + S F+IN TG + V+
Sbjct: 626 HYLIFGNSR---KKGFQINKKTGQIYVS 650
Score = 45.2 bits (102), Expect = 0.002
Identities = 49/171 (28%), Positives = 79/171 (46%), Gaps = 17/171 (9%)
Query: 36 LAQSIDSLVDSDSPQNVVKFRLGCDFDEGDDLVRIGAGL-NQISAYLSVTVYIEDVNDNV 94
L ++ + +D+ ++ KF+L D D G + + + L + ++ +TV +D N
Sbjct: 307 LNSEVEYFISNDN--HLGKFKL--DNDTG--WISVASSLISDLNQNFFITVTAKD-KGNP 359
Query: 95 PIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIFKDIRAFDRDKPNT 154
P+ H+TV E E + S TIP + G +I + + A DRD
Sbjct: 360 PLSSQATVHITVTE-----ENYHTPEFSQSHMSATIPESHSIG-SIVRTVSARDRDA--A 411
Query: 155 PNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASG 205
N + YSI SGN++G FA+ SS +L L K LDY+ K + G
Sbjct: 412 MNGLIKYSISSGNEEGIFAINSS-TGILTLAKALDYELCQKHEMTISAIDG 461
Score = 40.7 bits (91), Expect = 0.039
Identities = 19/36 (52%), Positives = 23/36 (63%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
+ Y SVTV + DVNDN P+FL Y TV E P+G
Sbjct: 467 TGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSG 502
Score = 35.1 bits (77), Expect = 2.0
Identities = 18/47 (38%), Positives = 27/47 (57%), Gaps = 1/47 (2%)
Query: 1436 LTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
+T +D DIGINA RY I++ P F I+P +G + + L R+
Sbjct: 83 VTRVTTSDEDIGINAISRYSIMDASLP-FTINPSTGDIVISRPLNRE 128
Score = 33.1 bits (72), Expect = 7.9
Identities = 19/73 (26%), Positives = 36/73 (49%), Gaps = 4/73 (5%)
Query: 1333 VRAERQKYSRELPHMIYPV-AEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAI 1391
+R+ R ++ H + + + D VKV++ I D NDN+P+F ++ +
Sbjct: 17 IRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRF---SQIFSAHV 73
Query: 1392 PTTAPFGYQVMQL 1404
P +P GY V ++
Sbjct: 74 PENSPLGYTVTRV 86
>AY354497-1|AAR10443.1| 2916|Homo sapiens cadherin protein protein.
Length = 2916
Score = 122 bits (293), Expect = 1e-26
Identities = 129/476 (27%), Positives = 214/476 (44%), Gaps = 33/476 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG-QNGMVLY 497
L S V + + + D ND++P F L S++ N +GT++ A D D N + Y
Sbjct: 1035 LSSTVFLSIDVEDQNDHSPSF-QDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQY 1093
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHA--LFVEASDQPANPSERRYSLAVV 555
++ S+ T+PF I+P+ GT+ E L V ASDQ N ++RR
Sbjct: 1094 YIE--SHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTA 1151
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND--VSYDLLHG 613
I + N P F+ P V +V +G+ V I +D E + V+Y +L G
Sbjct: 1152 QIVILDVNDHN----PTFISFPNAH-VKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSG 1206
Query: 614 YEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDE 672
E + F ++E SG++T L + + +AL + LS TV V+DVNDE
Sbjct: 1207 -NENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDE 1265
Query: 673 RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI-- 730
V + + VKEN F T + ++ + N + + ++
Sbjct: 1266 APVFKQHLYEA---SVKENQNPGE----FVTRVEALDRDSGVNSKLQFEIMPGASFELFE 1318
Query: 731 AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHA 790
++ G + T LDRE ++V+ + V+ + G S + + +EDEND+ P F +
Sbjct: 1319 INSDTGEVVTTTILDREIQEVFTLRVLVR-DGGFPSLSSTTTILCTVEDENDHAPEFIVS 1377
Query: 791 TYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTGVVKFI 849
+Y+ ++EN E ++ + A+D D G N Y + G E F ++E +G +
Sbjct: 1378 SYDIEVLENQ----EPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTT 1433
Query: 850 GDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVR 903
+LDRE+ + L ++ D G SS L + + D ND+ P F + S VR
Sbjct: 1434 R-ALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVR 1488
Score = 119 bits (287), Expect = 7e-26
Identities = 168/687 (24%), Positives = 285/687 (41%), Gaps = 58/687 (8%)
Query: 231 LRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQA 290
LRY L D +F + G ++L ++ D ++ F + L N T
Sbjct: 621 LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIV 680
Query: 291 RVEIELLDLNDNLPEFEVDFYNISIVEN-LPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
RV D NDN P F D + + E+ +P G + ++ A D D G+NG+ Y L
Sbjct: 681 RV----WDENDNSPTFLHDVLFLKVEESPVPQGV-IGKITAIDMDSGKNGQLLYFLLSDG 735
Query: 350 GAFSIDPRSGWL-TVRNQTVLDREAHSSLRMKVYAKETNPSVV--GTFAD--SQRIAKWR 404
F ++P +G T+ T D A S ++ + + V F + + W
Sbjct: 736 KFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWV 795
Query: 405 RQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVF---VP 461
E E T V D+ G+ N + + V V++ D NDN P F +P
Sbjct: 796 ALDREHRGHHEMTVLV-TDR-GSPPRN---------ATMAVYVSVTDINDNRPFFPQCLP 844
Query: 462 SNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVS 521
+ V ++ V A DPD G N V Y + S+ + FKI+ N G +
Sbjct: 845 GKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV---SSEDSSDHFKIDANNGEIR 901
Query: 522 VAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYE 579
+ R + + V A+DQ P + + AVV I+V +KG +
Sbjct: 902 TTTILSYDYRPSYRMSVIATDQGVPPLQGQ---AVVNIQVIPLSKGRAIMSQNIR----H 954
Query: 580 FWVGSNVGIGTSVGQIRVNDAFEQN---DVSYDLLHGYEEGVPFAVEERSGVITVVDDLS 636
+ N+ + I+ +D +Q+ + + ++ ++G F ++ +G + + +L
Sbjct: 955 LIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDG-HFEIDSSTGDLFLSKELD 1013
Query: 637 RYNRPMYDFEAVALQENANLSIVTNATVHV-VDVNDERGVLLKGAHSPIIFHVKENSAGA 695
Y F + + NLS+ ++TV + +DV D+ I+ V+EN
Sbjct: 1014 YETTSHYLFRVITTDHSKNLSL--SSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIG 1071
Query: 696 AIGQIFHTNMSSIYGNG-TGNVRFLIANQQDVTDDIAIAED-GTIFTQKPLDREKRDVYR 753
+ +F N G+ +++ I + T+ I GT+ T LDRE
Sbjct: 1072 TLVYVF--NAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVI 1129
Query: 754 MTVIAEFNKGVISGAGIYQVT--IYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNI 811
+TV A ++ + +T I I D ND+ P F + + E+ +G+ + +
Sbjct: 1130 LTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF-ISFPNAHVKEDVTVGSLV---HH 1185
Query: 812 IKATDADEGTNALFMYTLFGEGKEM-FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT 870
I A D DEG N Y++ + M F +DE++G++ LD E K + L+++A D
Sbjct: 1186 ITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLT-TTCPLDYEMKTQHILTVLALDD 1244
Query: 871 G--GLSSEAELIIMIGDENDNKPEFNQ 895
G LSS L + + D ND P F Q
Sbjct: 1245 GTPALSSSQTLTVTVLDVNDEAPVFKQ 1271
Score = 118 bits (284), Expect = 2e-25
Identities = 114/482 (23%), Positives = 208/482 (43%), Gaps = 39/482 (8%)
Query: 425 VGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKA 484
V + + D +L S + ++ +LD ND+NP F+ + +K + VG+++ + A
Sbjct: 1132 VTASDQAVNVTDRRLRS-LTAQIVILDVNDHNPTFI--SFPNAHVKEDVTVGSLVHHITA 1188
Query: 485 VDPDLGQNGMVLYD-LQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASD 540
DPD G+NG V Y L N+T F ++ ++G ++ P+ ++ +H L V A D
Sbjct: 1189 HDPDEGRNGKVTYSILSGNENMT----FMLDESSGLLTTT-CPLDYEMKTQHILTVLALD 1243
Query: 541 QPANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--N 598
+L V ++V + P F YE V N G V ++
Sbjct: 1244 DGTPALSSSQTLTVTVLDV-------NDEAPVFKQHLYEASVKENQNPGEFVTRVEALDR 1296
Query: 599 DAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQEN-ANLS 657
D+ + + ++++ G + F + +G + L R + ++ + +LS
Sbjct: 1297 DSGVNSKLQFEIMPGASFEL-FEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLS 1355
Query: 658 IVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR 717
T V D ND + ++ V EN + + ++M + GN
Sbjct: 1356 STTTILCTVEDENDHAPEFIVSSYD---IEVLENQEPEVVYTVLASDMDA--GNNRAVEY 1410
Query: 718 FLIANQQDVTDDIAIAE-DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIY 776
+I D + I E G + T + LDRE+ + + ++ + G + + + +
Sbjct: 1411 HIIDGNTD--ECFTINEMSGELSTTRALDREQISNFTLVILCS-DLGDPPRSSVIHLQVR 1467
Query: 777 IEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM 836
+ D ND+ P F Y+ + E++++GT + ++ A D DEG N Y L E
Sbjct: 1468 VLDANDHSPSFPTLYYQSSVREDAEVGTVVL---VLSAVDKDEGLNGQTEYFLTDEASGA 1524
Query: 837 FDVDENTGVVKFIGDSLDREKKIMYKLSLVARD---TGGLSSEAELIIMIGDENDNKPEF 893
F +D +G +K ++LDRE + + S VARD G S+ + + + D NDN P
Sbjct: 1525 FTIDPMSGTLK-TSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVL 1583
Query: 894 NQ 895
Q
Sbjct: 1584 EQ 1585
Score = 113 bits (273), Expect = 3e-24
Identities = 153/609 (25%), Positives = 260/609 (42%), Gaps = 45/609 (7%)
Query: 436 DEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMV 495
D S ++++V +LDAND++P F P+ Y+ S++ +A+VGTV+ + AVD D G NG
Sbjct: 1455 DPPRSSVIHLQVRVLDANDHSPSF-PTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQT 1513
Query: 496 LYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVV 555
Y L ++ F I+P +GT+ + + E R A + + R + ++
Sbjct: 1514 EYFLTDEAS----GAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVII 1569
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+ VT N P + P++ ++ + +R +D + + E
Sbjct: 1570 KVYVT-DVNDNDPVLEQ---NPFDVFLSPESPTNQTTVIVRADD-LDLGPNGTVVFSFAE 1624
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGV 675
F++++ +G I + S P++ V Q + T + V+ + E V
Sbjct: 1625 TQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQ---GIPARTTTGLLVIHMEGE-DV 1680
Query: 676 LLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAE 734
+ +H V EN AG +I + SI + ++ N+ V + +
Sbjct: 1681 KISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSI--FSGNEDGVLSLCSKSG 1738
Query: 735 DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIY-QVTIYIEDENDNPPVFEHATYE 793
T+ K LD E R+ ++ V+AE SG Y +V + I+DENDN P FE + Y+
Sbjct: 1739 QLTVKEPKFLDFEVRNEVQLIVLAES-----SGHRAYCKVAVLIQDENDNSPCFEQSIYQ 1793
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYT-LFGEGKEMFDVDENTGVVKFIGDS 852
+ E+ + + ATD D G N L Y+ L G +E F +D +GV+
Sbjct: 1794 ASVSESQLYNAHVIQ---VFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVIT-TKAI 1849
Query: 853 LDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKL 910
LD E Y L + A D G LS+ + + + D NDN P F E V I E L
Sbjct: 1850 LDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSE---AVEI-TEDSL 1905
Query: 911 NG--TAGFTIIEVKPKNKFALDV---DQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQ 965
G ++ +V + F G F I +N + ++ + LD + +
Sbjct: 1906 PGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGV---VVLVKTLDFEEMTEYE 1962
Query: 966 IRYEFNSEVYIPPSKLSADALEVK-RYFVINERHGHVIVARSLPPESEFRLNISALDGGN 1024
+ + + V+ L L+V V ++ V V S+P L +SA D +
Sbjct: 1963 LLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSV-LTLSATDLES 2021
Query: 1025 LNDNISVRV 1033
N+NIS R+
Sbjct: 2022 -NENISYRI 2029
Score = 104 bits (249), Expect = 3e-21
Identities = 88/326 (26%), Positives = 151/326 (46%), Gaps = 27/326 (8%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPI----GPSL 128
G +S+ ++TV + DVND P+F Y +V E GE F+ + + G +
Sbjct: 1245 GTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGE--FVTRVEALDRDSGVNS 1302
Query: 129 TIPLTVPRGLTI-FKDIRAFDRDKPNTPNSDVH----YSIVSGNDDGHFALESSHKPVLL 183
+ + G + +I + + T D +++ DG F SS +L
Sbjct: 1303 KLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILC 1362
Query: 184 LRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI---DQDLGVGATLRYELISGND 240
+ D D + ++ + + E PE ++ + D D G + Y +I GN
Sbjct: 1363 TVE----DENDHAPEFIVSSYDIEV-LENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNT 1417
Query: 241 RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLN 300
+ F+++ ++G L + LD + Q + F L + S L +P +++ +++ +LD N
Sbjct: 1418 DECFTINEMSGELSTTRALDRE-----QISNFTLVILCSDLGDPPRSSVIHLQVRVLDAN 1472
Query: 301 DNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-DDPKGAFSIDPRSG 359
D+ P F +Y S+ E+ G VL + A DKD+G NG+ Y L D+ GAF+IDP SG
Sbjct: 1473 DHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSG 1532
Query: 360 WLTVRNQTVLDREAHSSLRMKVYAKE 385
T++ LDREA S A++
Sbjct: 1533 --TLKTSNTLDREARSQHTFSAVARD 1556
Score = 100 bits (239), Expect = 5e-20
Identities = 111/465 (23%), Positives = 199/465 (42%), Gaps = 44/465 (9%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
++V + D NDN P F+PS E + ++ G ++ V D DL N ++ + SN
Sbjct: 1878 IKVQVTDINDNAPAFLPSEAVEIT--EDSLPGVIVTHVSVHDVDL--NSAFIFSFAKESN 1933
Query: 505 LTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
+ F I+ NTG V + ++ E + L ++ SD Y+ + + V
Sbjct: 1934 PG--TKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSV------HYTEGALVVRVL-- 1983
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAV 622
+ P P F Y+ V ++ +G SV + D ++SY +L +E F++
Sbjct: 1984 DVNDNP--PVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKE---FSI 2038
Query: 623 EERSGVITVVDD---LSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVL-LK 678
+ ++G I + L + + EA + N +L +T + + D+N+ +K
Sbjct: 2039 DPKNGTIFTISPVLLLDTISTTQFLVEA-SDGGNPDLRALTLVEIGIEDMNNYAPEFTVK 2097
Query: 679 GAHSPIIFHVKENSAGAAIGQIFH--------TNMSSIYGNGTGNVRFLIANQQDVTDDI 730
+ + S I H S I GN N + +
Sbjct: 2098 SYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFH---VETKFFHSEY 2154
Query: 731 AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHA 790
+ G + LDRE + + ++A + G + ++I + D NDNPP F
Sbjct: 2155 PYKQVGYLVLLHSLDREASASHELVILAS-DSGCPPLSSTAVISIQVLDVNDNPPNFSSL 2213
Query: 791 TYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTGVVKFI 849
+Y + E++ +G+ I ++ A D D G++A +Y + G K F ++ENTGV+ I
Sbjct: 2214 SYHTHVKESTPLGSHI---TVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLI 2270
Query: 850 GDSLDREKKIMYKLSLVARDTGGLS-SEAELIIMIGDENDNKPEF 893
LD EK + L++ A D S A + + + D+ND+ P+F
Sbjct: 2271 -KPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSVLDDNDHAPQF 2314
Score = 97.5 bits (232), Expect = 3e-19
Identities = 115/438 (26%), Positives = 194/438 (44%), Gaps = 49/438 (11%)
Query: 916 FTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLD-SGLNGQIRYEFNSEV 974
F I+V+ +N + + + EN+PIGT + NA D D S LN +I+Y
Sbjct: 1040 FLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQY------ 1093
Query: 975 YIPPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGG-NLND---- 1027
YI + F+I+ G ++ L ES L ++A D N+ D
Sbjct: 1094 YIESHNPGTNP------FLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLR 1147
Query: 1028 NISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
+++ ++ + DVNDH P F ++ N +V+E ++ + A D D G+N +TY I
Sbjct: 1148 SLTAQIVILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSG 1206
Query: 1088 DTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDN 1147
+ ++ F + +G+L+ LD E + ++ILTV+A D+G DVND
Sbjct: 1207 NENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDG-TPALSSSQTLTVTVLDVNDE 1265
Query: 1148 SPKFYAFDELLEWKHPEADELSNHN-FESVMMIPVYKATIEENAPIGTTVAKVFANDTDF 1206
+P F + L EA N N E V + N+ + + + +
Sbjct: 1266 AP---VFKQHLY----EASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFE 1318
Query: 1207 IGNGNG-LILYSLPQRKNQQ---------NLGLPSLSSTAILMVTVADVPDEVEMSDKPV 1256
I + G ++ ++ R+ Q+ + G PSLSST ++ TV D D P
Sbjct: 1319 INSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHA-----PE 1373
Query: 1257 FISRYYELEIEENVNAPVELVSL-NLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTL 1315
FI Y++E+ EN V L + + N + Y+I++ N TD F I+ +G L
Sbjct: 1374 FIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGN-TD--ECFTINEMSGEL 1430
Query: 1316 YLVRSPDREVKDTYEVIV 1333
R+ DRE + +++
Sbjct: 1431 STTRALDREQISNFTLVI 1448
Score = 97.5 bits (232), Expect = 3e-19
Identities = 105/418 (25%), Positives = 177/418 (42%), Gaps = 34/418 (8%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L S + VT+LD ND PVF +LYE S+K N G + +V+A+D D G N + ++
Sbjct: 1249 LSSSQTLTVTVLDVNDEAPVF-KQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFE 1307
Query: 499 LQRTSNLTITSPFKINPNTG---TVSVAESPILEGRHALFVEASDQPANPSERRYSLAVV 555
+ ++ + F+IN +TG T ++ + I E L V D PS + +
Sbjct: 1308 IMPGASFEL---FEINSDTGEVVTTTILDREIQE-VFTLRVLVRD-GGFPSLSSTTTILC 1362
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN-DAFEQNDVSYDLLHGY 614
T+E P+F+ + Y+ V N + + DA V Y ++ G
Sbjct: 1363 TVE------DENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGN 1416
Query: 615 EEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN---LSIVTNATVHVVDVND 671
+ F + E SG ++ L R + +F V L + S V + V V+D ND
Sbjct: 1417 TDEC-FTINEMSGELSTTRALDR--EQISNFTLVILCSDLGDPPRSSVIHLQVRVLDAND 1473
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNG-TGNVRFLIANQQDVTDDI 730
P +++ A +G + + G G + + ++ I
Sbjct: 1474 H------SPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTI 1527
Query: 731 AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHA 790
GT+ T LDRE R + + +A S + + +Y+ D NDN PV E
Sbjct: 1528 D-PMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQN 1586
Query: 791 TYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
++ F+ S + I++A D D G N +++ F E + MF +D+ TG ++F
Sbjct: 1587 PFDVFLSPESPTN---QTTVIVRADDLDLGPNGTVVFS-FAETQSMFSIDKYTGEIQF 1640
Score = 94.3 bits (224), Expect = 3e-18
Identities = 164/701 (23%), Positives = 286/701 (40%), Gaps = 81/701 (11%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
++ V V + D NDN+P F S +Y+ S+ + + +V A D D G NG++ Y +
Sbjct: 1769 AYCKVAVLIQDENDNSPCFEQS-IYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSIL 1827
Query: 501 RTSNLTITSPFKINPNTGTVSVAE--SPILEGRHALFVEASDQPANPSERRYSLAVVTIE 558
+ F+I+ +G ++ L ++L V+A+D+ R + V+ ++
Sbjct: 1828 SGNQ---EEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGM---PRLSNTTVIKVQ 1881
Query: 559 VTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGV 618
VT +P E + + SV + +N AF + G
Sbjct: 1882 VTDINDNAPAFLPSEAVEITEDSLPGVIVTHVSVHDVDLNSAF-----IFSFAKESNPGT 1936
Query: 619 PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNA-TVHVVDVNDERGVLL 677
FA+++ +GV+ +V L Y+ + +Q + ++ A V V+DVND V
Sbjct: 1937 KFAIDQNTGVVVLVKTLDFEEMTEYE---LLIQISDSVHYTEGALVVRVLDVNDNPPVFS 1993
Query: 678 KGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGT 737
+ + + + G ++ + T++ S N + R L ++++ D ++GT
Sbjct: 1994 QDFYQVTV--PESIPVGYSVLTLSATDLES---NENISYRILSSSKEFSIDP----KNGT 2044
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
IFT P+ ++ + G + V I IED N+ P F +Y +
Sbjct: 2045 IFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLS 2104
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREK 857
E++ +G+ + + I E T + + G + F V+ KF K
Sbjct: 2105 EDALVGSTLVTFSNIDHDWTRENTYVEYSI-ISGNSQNNFHVE-----TKFFHSEYPY-K 2157
Query: 858 KIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFT 917
++ Y + L + D +S EL+I+ D L+ TA +
Sbjct: 2158 QVGYLVLLHSLDREASASH-ELVILASDSGC-------------------PPLSSTAVIS 2197
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
I +V N + L + E+ P+G+ I ++A D D+G + +I Y S
Sbjct: 2198 I-QVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISG---- 2252
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDNISVR-VF 1034
K +F + E G + + + L E ++F L + A D + + +V V
Sbjct: 2253 ---------NEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVS 2303
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPS------ 1087
V D NDH P F + ++ V E + ++A D D G LTY + P
Sbjct: 2304 VLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGM 2363
Query: 1088 --DTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
D DL F I PLTG + LD E +KY LTV A+D G
Sbjct: 2364 SYDHDL-FLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKG 2403
Score = 91.9 bits (218), Expect = 2e-17
Identities = 76/291 (26%), Positives = 132/291 (45%), Gaps = 18/291 (6%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTD 1090
V V ++D ND+ P F+++ Y +V E+Q + +V ATD D G N + Y I + +
Sbjct: 1773 VAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQE 1832
Query: 1091 LPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
F+I L+GV++ LD E Y L V A D G D+NDN+P
Sbjct: 1833 EAFQIDALSGVITTKAILDYELTSSYSLIVQATDKG-MPRLSNTTVIKVQVTDINDNAPA 1891
Query: 1151 FYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDF-IGN 1209
F EA E++ + V++ V ++ N+ + AK T F I
Sbjct: 1892 FLP---------SEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQ 1942
Query: 1210 GNG-LILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDK-PVFISRYYELEIE 1267
G ++L + L S ++ A V ++++D PVF +Y++ +
Sbjct: 1943 NTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVP 2002
Query: 1268 ENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLV 1318
E++ +++L+ T+ N + Y IL+ + + F IDP+NGT++ +
Sbjct: 2003 ESIPVGYSVLTLSATDLESNENISYRILSSS-----KEFSIDPKNGTIFTI 2048
Score = 90.2 bits (214), Expect = 5e-17
Identities = 182/835 (21%), Positives = 313/835 (37%), Gaps = 71/835 (8%)
Query: 572 DFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITV 631
+F Y F V +V + +G ++ + ++ + + + G F++ R G I
Sbjct: 376 EFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRT 435
Query: 632 VDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKEN 691
L +P+ A +A T + V+DVND L+ S I +
Sbjct: 436 RKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLR--TSDEIRISQTT 493
Query: 692 SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDV 751
G A ++ G +R+ IA+ Q I A G +F L ++
Sbjct: 494 PPGTA---LYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRAL-GVLFLNGSLGAGEQRE 549
Query: 752 YRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP-VFEHATYEGFIMENSKIGTEIKMDN 810
+T+ AE ++GV A + +T+ IE +P FEH Y+ + E+ T++ +
Sbjct: 550 LTLTLRAE-DQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQM-LQT 607
Query: 811 IIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVA--R 868
+ L MF + TG + ++ D E Y + A
Sbjct: 608 QAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWI-YLRRQFDYESTQTYNFRVFAWIP 666
Query: 869 DTGGLSS-EAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAG-FTIIEVKPKNK 926
+ G L + +I+ + DENDN P F + + +++ G G T I++
Sbjct: 667 EDGFLQNVSTTVIVRVWDENDNSPTF--LHDVLFLKVEESPVPQGVIGKITAIDMDSGKN 724
Query: 927 FALDVDQL--GPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSAD 984
L L G F + N TI + D + +G + F+S+ +L A
Sbjct: 725 GQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSG-TDFAFSSD------ELQAF 777
Query: 985 ALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHF 1042
L+ + + E VA + + D G+ N ++V V V D+ND+
Sbjct: 778 VLK-SLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 836
Query: 1043 PVFKKTW----YNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPL 1098
P F + + V E Q ++ V A D D G NA +TY + D+ F+I
Sbjct: 837 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDAN 896
Query: 1099 TGVLSVNGELDRETEDKYILTVVARD------NGXXXXXXXXXXXXXXXXDVNDNSPKFY 1152
G + L + Y ++V+A D G ++ N
Sbjct: 897 NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLI 956
Query: 1153 AFDELLEWKHPEADELSNH---NFESVMMIPVYKATIEENAPIGTTVAKVF-ANDTDFIG 1208
+ L K + S+H ++ + + + + I ++ +F + + D+
Sbjct: 957 IPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYET 1016
Query: 1209 NGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEE 1268
+ L+ + + +NL SLSST L + V D D P F + +EE
Sbjct: 1017 TSH--YLFRVITTDHSKNL---SLSSTVFLSIDVEDQNDH-----SPSFQDELIVISVEE 1066
Query: 1269 NVNAPVELVSLNLTE---HYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREV 1325
NV + N + + N +++YYI + N F+I P GTL V DRE
Sbjct: 1067 NVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPG--TNPFLIHPSFGTLVTVSRLDRES 1124
Query: 1326 KDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF 1380
T + V A Q + V + L +T V I DVND++P F
Sbjct: 1125 IPTVILTVTASDQAVN---------VTDRRLRSLTAQIV-----ILDVNDHNPTF 1165
Score = 81.0 bits (191), Expect = 3e-14
Identities = 102/399 (25%), Positives = 159/399 (39%), Gaps = 42/399 (10%)
Query: 992 FVINERHGHVIVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F INE G + R+L E S F L I D G+ + I ++V V D NDH P F
Sbjct: 1421 FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPT 1480
Query: 1048 TWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGE 1107
+Y +V E V+ + A D D G N YF+ + F I P++G L +
Sbjct: 1481 LYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLT-DEASGAFTIDPMSGTLKTSNT 1539
Query: 1108 LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP--KFYAFDELLEWKHPEA 1165
LDRE ++ + VARD DVNDN P + FD L + P
Sbjct: 1540 LDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTN 1599
Query: 1166 DELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQ 1225
+ + + P + + F N + Q K
Sbjct: 1600 QTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLK-VT 1658
Query: 1226 NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLN-LTEH 1284
+ G+P+ ++T +L++ + ++V++S F Y+ + EN A +V++
Sbjct: 1659 DQGIPARTTTGLLVIHMEG--EDVKIS----FSHHLYKGLVTENCEAGTSIVTVKAFAPD 1712
Query: 1285 YENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSP---DREVKDTYEVIVRAERQKYS 1341
M+Y I + N+ + + ++G L V+ P D EV++ ++IV AE
Sbjct: 1713 SIQDSMKYSIFSGNEDGV---LSLCSKSGQL-TVKEPKFLDFEVRNEVQLIVLAESS--- 1765
Query: 1342 RELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF 1380
H Y KV V I+D NDNSP F
Sbjct: 1766 ---GHRAY--------------CKVAVLIQDENDNSPCF 1787
Score = 79.8 bits (188), Expect = 7e-14
Identities = 70/234 (29%), Positives = 104/234 (44%), Gaps = 26/234 (11%)
Query: 929 LDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LDV+ P+F + EN G + ++ ALD DSG+N ++++E +P +
Sbjct: 1260 LDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEI-----MPGASF 1314
Query: 982 SADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKD 1037
F IN G V+ L E + F L + DGG +L+ ++ V+D
Sbjct: 1315 --------ELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVED 1366
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISP 1097
NDH P F + Y+ V E Q V+ V A+D D G N + Y I +TD F I+
Sbjct: 1367 ENDHAPEFIVSSYDIEVLENQ-EPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINE 1425
Query: 1098 LTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
++G LS LDRE + L ++ D G D ND+SP F
Sbjct: 1426 MSGELSTTRALDREQISNFTLVILCSDLG-DPPRSSVIHLQVRVLDANDHSPSF 1478
Score = 79.4 bits (187), Expect = 9e-14
Identities = 93/367 (25%), Positives = 151/367 (41%), Gaps = 38/367 (10%)
Query: 991 YFVINERHGHVIVARSLPPE--SEFRLNISALDGG---NLNDNISVRVFVKDVNDHFPVF 1045
+F I+ G + +++ L E S + + D +L+ + + + V+D NDH P F
Sbjct: 996 HFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSF 1055
Query: 1046 KKTWYNFNVEEAQYTRRVLGKVDATDADFG-QNANLTYFIQPSDTDL-PFEISPLTGVLS 1103
+ +VEE ++ +A D D N+ + Y+I+ + PF I P G L
Sbjct: 1056 QDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLV 1115
Query: 1104 VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXX--DVNDNSPKFYAFDELLEWK 1161
LDRE+ ILTV A D DVND++P F +F +
Sbjct: 1116 TVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPNAHVKE 1175
Query: 1162 HPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLP-- 1219
L +H I + N + ++ N T + +GL+ + P
Sbjct: 1176 DVTVGSLVHH-------ITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLD 1228
Query: 1220 -QRKNQQNL-------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVN 1271
+ K Q L G P+LSS+ L VTV DV DE PVF YE ++EN N
Sbjct: 1229 YEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEA-----PVFKQHLYEASVKENQN 1283
Query: 1272 APVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKD-- 1327
+ + + N K+++ I+ ++ F I+ G + DRE+++
Sbjct: 1284 PGEFVTRVEALDRDSGVNSKLQFEIMPGASFEL---FEINSDTGEVVTTTILDREIQEVF 1340
Query: 1328 TYEVIVR 1334
T V+VR
Sbjct: 1341 TLRVLVR 1347
Score = 76.2 bits (179), Expect = 9e-13
Identities = 79/315 (25%), Positives = 134/315 (42%), Gaps = 19/315 (6%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI--APIGPSLTIPLTVP 135
S + + VY+ DVNDN P+ P+ V + +PT + I +GP+ T+ +
Sbjct: 1564 STTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFA 1623
Query: 136 RGLTIFK-DIRAFDRDKPNTPNSDVH--YSIVSGNDDGHFALESSHKPVLLLRKVLDYDA 192
++F D + P+S+ + + D G A ++ V+ + +
Sbjct: 1624 ETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDVKIS 1683
Query: 193 GDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGS 252
++ I+ + A D + +++Y + SGN+ + SL S +G
Sbjct: 1684 FSHHLYKGLVTENCEAGTSIV---TVKAFAPD-SIQDSMKYSIFSGNEDGVLSLCSKSGQ 1739
Query: 253 LFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN 312
L +++ LD E + VL + A +V + + D NDN P FE Y
Sbjct: 1740 LTVKEPKFLDFEVRNEVQLIVLAESSGH------RAYCKVAVLIQDENDNSPCFEQSIYQ 1793
Query: 313 ISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLD 370
S+ E+ V+QV ATD D G NG Y + + + AF ID SG +T + +LD
Sbjct: 1794 ASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTK--AILD 1851
Query: 371 REAHSSLRMKVYAKE 385
E SS + V A +
Sbjct: 1852 YELTSSYSLIVQATD 1866
Score = 74.5 bits (175), Expect = 3e-12
Identities = 44/151 (29%), Positives = 83/151 (54%), Gaps = 7/151 (4%)
Query: 939 LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERH 998
++PEN+PI +TI +NALD D+G G++ Y S ++ +S D F+I+
Sbjct: 2322 IVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHG-MSYD----HDLFLIDPLT 2376
Query: 999 GHVIVARSLPPES--EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
G + + L E+ ++ L + A D G+ ++ V V ++ +++ P+F + Y F + E
Sbjct: 2377 GDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPE 2436
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
R+++G+V+A+DAD G + + Y + S
Sbjct: 2437 KNKDRQLIGRVEASDADAGIDGVILYSLGTS 2467
Score = 74.1 bits (174), Expect = 3e-12
Identities = 56/178 (31%), Positives = 85/178 (47%), Gaps = 18/178 (10%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D+D G A + Y +ISGN++ F L+ G L+L K LD + + F L VQ
Sbjct: 2232 VSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYE-----KMTKFTLTVQ 2286
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
AS + A V + +LD ND+ P+F ++ + ENLP ++ + A D D G
Sbjct: 2287 ASDAEKK-HFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGP 2345
Query: 338 NGEFTYQLDDP----------KGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
GE TY + P F IDP +G + + +LD E + + V AK+
Sbjct: 2346 YGELTYSIVSPCFLTHGMSYDHDLFLIDPLTG--DIHAKQILDYENGNKYCLTVQAKD 2401
Score = 71.7 bits (168), Expect = 2e-11
Identities = 67/229 (29%), Positives = 102/229 (44%), Gaps = 14/229 (6%)
Query: 160 HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEF-QLVIMASGKRIHKEILFPEPI 218
H V DDG AL SS L VLD + F Q + AS K F +
Sbjct: 1235 HILTVLALDDGTPALSSSQT---LTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRV 1291
Query: 219 HAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQA 278
A+D+D GV + L++E++ G +LF ++S G + LD + + F L+V
Sbjct: 1292 EALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQ-----EVFTLRVLV 1346
Query: 279 SQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGEN 338
P ++ + + D ND+ PEF V Y+I ++EN V V+A+D D G N
Sbjct: 1347 RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLEN-QEPEVVYTVLASDMDAGNN 1405
Query: 339 GEFTYQLDD--PKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
Y + D F+I+ SG L+ LDRE S+ + + +
Sbjct: 1406 RAVEYHIIDGNTDECFTINEMSGELSTTR--ALDREQISNFTLVILCSD 1452
Score = 71.3 bits (167), Expect = 2e-11
Identities = 53/178 (29%), Positives = 82/178 (46%), Gaps = 8/178 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I A D D G + Y ++SGN+ F LD +G L LD E Q +L V
Sbjct: 1186 ITAHDPDEGRNGKVTYSILSGNENMTFMLDESSG--LLTTTCPLDYEMKTQ---HILTVL 1240
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P ++ + + +LD+ND P F+ Y S+ EN G V +V A D+D G
Sbjct: 1241 ALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGV 1300
Query: 338 NGEFTYQLDDPKGAFSI-DPRSGWLTVRNQTVLDREAHSSLRMKVYAKETN-PSVVGT 393
N + +++ P +F + + S V T+LDRE ++V ++ PS+ T
Sbjct: 1301 NSKLQFEI-MPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSST 1357
Score = 68.9 bits (161), Expect = 1e-10
Identities = 41/128 (32%), Positives = 71/128 (55%), Gaps = 11/128 (8%)
Query: 244 FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNL 303
F++D G + L K LD + + + L +Q S + + + + + +LD+NDN
Sbjct: 1938 FAIDQNTGVVVLVKTLDFE-----EMTEYELLIQIS---DSVHYTEGALVVRVLDVNDNP 1989
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWL-T 362
P F DFY +++ E++P G+SVL + ATD + EN +Y++ FSIDP++G + T
Sbjct: 1990 PVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSKEFSIDPKNGTIFT 2047
Query: 363 VRNQTVLD 370
+ +LD
Sbjct: 2048 ISPVLLLD 2055
Score = 68.5 bits (160), Expect = 2e-10
Identities = 115/480 (23%), Positives = 199/480 (41%), Gaps = 63/480 (13%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLT 506
V +LD NDN PVF + Y+ ++ + VG + + A D + +N + Y + L+
Sbjct: 1980 VRVLDVNDNPPVF-SQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRI-----LS 2031
Query: 507 ITSPFKINPNTGTVSVAESPILE----GRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
+ F I+P GT+ SP+L VEASD NP R +L + IE
Sbjct: 2032 SSKEFSIDPKNGTIFTI-SPVLLLDTISTTQFLVEASDG-GNPDLRALTLVEIGIEDMNN 2089
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSV---GQIRVNDAFEQNDVSYDLLHGYEEGVP 619
P+F Y + + +G+++ I + E V Y ++ G +
Sbjct: 2090 YA------PEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQN-N 2142
Query: 620 FAVE----------ERSGVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVD 668
F VE ++ G + ++ L R ++ +A LS ++ V+D
Sbjct: 2143 FHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLD 2202
Query: 669 VNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIAN--QQDV 726
VND ++ HVKE++ +G H + S TG+ +I N +
Sbjct: 2203 VNDNPPNFSSLSYHT---HVKESTP---LGS--HITVVSANDRDTGSHAEIIYNIISGNE 2254
Query: 727 TDDIAIAED-GTIFTQKPLDREKRDVYRMTVIA-EFNKGVISGAGIYQVTIYIEDENDNP 784
+ E+ G ++ KPLD EK + +TV A + K S A ++ + + D+ND+
Sbjct: 2255 KGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVF---VSVLDDNDHA 2311
Query: 785 PVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL---------FGEGKE 835
P F +++ + EN I + I I A D D G Y++ +
Sbjct: 2312 PQFMFSSFSCIVPENLPISSTICS---INALDFDAGPYGELTYSIVSPCFLTHGMSYDHD 2368
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQ 895
+F +D TG + LD E Y L++ A+D G ++ + + I ++ +P F Q
Sbjct: 2369 LFLIDPLTGDI-HAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFEPIFTQ 2427
Score = 67.3 bits (157), Expect = 4e-10
Identities = 111/465 (23%), Positives = 186/465 (40%), Gaps = 37/465 (7%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L S + T+ D ND+ P F+ S+ Y+ + N + V+ V A D D G N V Y
Sbjct: 1354 LSSTTTILCTVEDENDHAPEFIVSS-YDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYH 1411
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVT 556
+ + F IN +G +S + E L + SD P L V
Sbjct: 1412 IIDGNT---DECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRV 1468
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEE 616
++ + P P Y+ V + +GT V + D E + + E
Sbjct: 1469 LDAN----DHSPSFPTLY---YQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEA 1521
Query: 617 GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVA----LQENANLSIVTNATVHVVDVNDE 672
F ++ SG + + L R R + F AVA +Q + + +++ V+V DVND
Sbjct: 1522 SGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIK--VYVTDVNDN 1579
Query: 673 RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI 732
VL +P + S I + + NGT V F A Q +
Sbjct: 1580 DPVL---EQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGT--VVFSFAETQSMFSIDKY 1634
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
G I Q+ E ++ + + +G+ + + I++E E D F H Y
Sbjct: 1635 T--GEIQFQQNPSSEYFPIWLQLKVTD--QGIPARTTTGLLVIHMEGE-DVKISFSHHLY 1689
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTGVVKFIGD 851
+G + EN + GT I +KA D +++ Y++F G + + +G +
Sbjct: 1690 KGLVTENCEAGTSIV---TVKAFAPDSIQDSM-KYSIFSGNEDGVLSLCSKSGQLTVKEP 1745
Query: 852 S-LDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQ 895
LD E + +L +V ++ G + ++ ++I DENDN P F Q
Sbjct: 1746 KFLDFEVRNEVQL-IVLAESSGHRAYCKVAVLIQDENDNSPCFEQ 1789
Score = 65.7 bits (153), Expect = 1e-09
Identities = 88/364 (24%), Positives = 156/364 (42%), Gaps = 34/364 (9%)
Query: 992 FVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTW 1049
F I++ G V++ ++L E +E+ L I D + + V V V DVND+ PVF + +
Sbjct: 1938 FAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALV-VRVLDVNDNPPVFSQDF 1996
Query: 1050 YNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG-VLSVNGEL 1108
Y V E+ + + ATD + N N++Y I S + F I P G + +++ L
Sbjct: 1997 YQVTVPESIPVGYSVLTLSATDLE--SNENISYRILSSSKE--FSIDPKNGTIFTISPVL 2052
Query: 1109 DRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADEL 1168
+T V A D G D+N+ +P+F L
Sbjct: 2053 LLDTISTTQFLVEASDGGNPDLRALTLVEIGIE-DMNNYAPEFTVKSYNLSLSEDALVGS 2111
Query: 1169 SNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGN-------GNGLILYSLPQR 1221
+ F ++ + T E + I F +T F + G ++L+SL +
Sbjct: 2112 TLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDRE 2171
Query: 1222 KNQQN--------LGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VN 1271
+ + G P LSSTA++ + V DV D + P F S Y ++E+ +
Sbjct: 2172 ASASHELVILASDSGCPPLSSTAVISIQVLDVND-----NPPNFSSLSYHTHVKESTPLG 2226
Query: 1272 APVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEV 1331
+ + +VS N + + ++ Y I++ N+ + F ++ G LYL++ D E + +
Sbjct: 2227 SHITVVSANDRDTGSHAEIIYNIISGNE---KGHFYLEENTGVLYLIKPLDYEKMTKFTL 2283
Query: 1332 IVRA 1335
V+A
Sbjct: 2284 TVQA 2287
Score = 63.7 bits (148), Expect = 5e-09
Identities = 96/428 (22%), Positives = 182/428 (42%), Gaps = 35/428 (8%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPD-LGQNGMVLY 497
L + VE+ + D N+ P F + Y S+ +A VG+ + +D D +N V Y
Sbjct: 2074 LRALTLVEIGIEDMNNYAPEFTVKS-YNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEY 2132
Query: 498 DL---QRTSNLTITSPFKINP----NTGTVSVAESPILEGR--HALFVEASDQPANPSER 548
+ +N + + F + G + + S E H L + ASD P
Sbjct: 2133 SIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLS- 2191
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDV 606
S AV++I+V + P P+F Y V + +G+ + + ND ++
Sbjct: 2192 --STAVISIQVL--DVNDNP--PNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEI 2245
Query: 607 SYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHV 666
Y+++ G E+G F +EE +GV+ ++ L + A V V
Sbjct: 2246 IYNIISGNEKG-HFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFAVVFVSV 2304
Query: 667 VDVNDERGVLLKGAHSPII-FHVKENSAGAAIGQIFHTNMSSIYGNGTGNV--RFLIANQ 723
+D ND + + S I+ ++ +S +I + + YG T ++ + +
Sbjct: 2305 LDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFD--AGPYGELTYSIVSPCFLTHG 2362
Query: 724 QDVTDDIAIAED--GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
D+ + + G I ++ LD E + Y +TV A+ +KG + + + V + IE +
Sbjct: 2363 MSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAK-DKGDATASLV--VWVDIEGID 2419
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDE 841
+ P+F Y + E +K + ++ ++A+DAD G + + +Y+L G F V++
Sbjct: 2420 EFEPIFTQDQYFFTLPEKNK---DRQLIGRVEASDADAGIDGVILYSL-GTSSPFFSVNK 2475
Query: 842 NTGVVKFI 849
G + I
Sbjct: 2476 TNGNIYLI 2483
Score = 62.1 bits (144), Expect = 1e-08
Identities = 89/363 (24%), Positives = 147/363 (40%), Gaps = 38/363 (10%)
Query: 47 DSPQNVVKFRLGCDFDEGDD---LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYH 103
D VV DF+E + L++I ++ L V V DVNDN P+F Y
Sbjct: 1941 DQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVL--DVNDNPPVFSQDFYQ 1998
Query: 104 VTVDELTPTGEKAFIFLIAPIGPSLTIPLTV----------PRGLTIFKDIRAFDRDKPN 153
VTV E P G + + I + P+ TIF D +
Sbjct: 1999 VTVPESIPVGYSVLTLSATDLESNENISYRILSSSKEFSIDPKNGTIFTISPVLLLDTIS 2058
Query: 154 TPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEIL 213
T +V +D G+ L + L L ++ D + + + + + ++ L
Sbjct: 2059 TTQF-----LVEASDGGNPDLRA-----LTLVEIGIEDMNNYAPEFTVKSYNLSLSEDAL 2108
Query: 214 FPEPIHA---IDQDLGVGAT-LRYELISGNDRKLFSLDS-VNGSLFLEKELD-LDAEHNL 267
+ ID D T + Y +ISGN + F +++ S + K++ L H+L
Sbjct: 2109 VGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSL 2168
Query: 268 QANTFV---LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFS 324
L + AS P ++ A + I++LD+NDN P F Y+ + E+ P G
Sbjct: 2169 DREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSH 2228
Query: 325 VLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVY 382
+ V A D+D G + E Y + + KG F ++ +G L + LD E + + V
Sbjct: 2229 ITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKP--LDYEKMTKFTLTVQ 2286
Query: 383 AKE 385
A +
Sbjct: 2287 ASD 2289
Score = 59.3 bits (137), Expect = 1e-07
Identities = 49/184 (26%), Positives = 81/184 (44%), Gaps = 9/184 (4%)
Query: 208 IHKEILFPEPIHAID--QDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEH 265
+++++ PI + + L + Y + SG+ FS+ G++ K LD H
Sbjct: 386 VYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLD----H 441
Query: 266 NLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSV 325
Q VL VQA QL + + V I ++D+NDN P F I I + P G ++
Sbjct: 442 ETQP-VVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTAL 499
Query: 326 LQVMATDKDQGENGEFTYQLDDPK-GAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAK 384
A D+D G NG Y + P+ G F+ID G L + + +L ++ +
Sbjct: 500 YLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQ 559
Query: 385 ETNP 388
+P
Sbjct: 560 GVHP 563
Score = 58.0 bits (134), Expect = 2e-07
Identities = 37/143 (25%), Positives = 70/143 (48%), Gaps = 7/143 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G+ + Y ++SGN + F +D+++G + + LD + +++ L VQ
Sbjct: 1809 VFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYEL-----TSSYSLIVQ 1863
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A+ P + +++++ D+NDN P F + + I E+ G V V D D
Sbjct: 1864 ATDKGMPRLSNTTVIKVQVTDINDNAPAF-LPSEAVEITEDSLPGVIVTHVSVHDVDLNS 1922
Query: 338 NGEFTYQLD-DPKGAFSIDPRSG 359
F++ + +P F+ID +G
Sbjct: 1923 AFIFSFAKESNPGTKFAIDQNTG 1945
Score = 56.4 bits (130), Expect = 7e-07
Identities = 92/415 (22%), Positives = 165/415 (39%), Gaps = 48/415 (11%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
E P+ + + A D D G N ++ Y +SE K+ A+ E++ +++ +
Sbjct: 854 EGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDY--- 910
Query: 1002 IVARSLPPESEFRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQY 1059
+R+++ A D G L V + V ++ + + + + E
Sbjct: 911 --------RPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLK 962
Query: 1060 TRRVLGKVDATD-ADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYIL 1118
+++ + ++D N L + I D D FEI TG L ++ ELD ET Y+
Sbjct: 963 PTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLF 1022
Query: 1119 TVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMM 1178
V+ D+ D ND+SP F DEL+ E N +
Sbjct: 1023 RVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQ--DELIVISVEE-------NVPIGTL 1073
Query: 1179 IPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAIL 1238
+ V+ A ++ + + + + + G LI S L S+ T IL
Sbjct: 1074 VYVFNAKDDDGSFLNSRIQYYIESHNP--GTNPFLIHPSFGTLVTVSRLDRESI-PTVIL 1130
Query: 1239 MVTVAD----VPDE-----------VEMSD-KPVFISRYYELEIEEN--VNAPVELVSLN 1280
VT +D V D ++++D P FIS + ++E+ V + V ++ +
Sbjct: 1131 TVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFIS-FPNAHVKEDVTVGSLVHHITAH 1189
Query: 1281 LTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
+ N K+ Y IL+ N+ TF++D +G L D E+K + + V A
Sbjct: 1190 DPDEGRNGKVTYSILSGNE---NMTFMLDESSGLLTTTCPLDYEMKTQHILTVLA 1241
Score = 56.0 bits (129), Expect = 1e-06
Identities = 47/157 (29%), Positives = 70/157 (44%), Gaps = 6/157 (3%)
Query: 999 GHVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNV 1054
G++++ SL E+ L I A D G L+ + + V DVND+ P F Y+ +V
Sbjct: 2160 GYLVLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHV 2219
Query: 1055 EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETED 1114
+E+ + V A D D G +A + Y I + F + TGVL + LD E
Sbjct: 2220 KESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMT 2279
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
K+ LTV A D D ND++P+F
Sbjct: 2280 KFTLTVQASD--AEKKHFSFAVVFVSVLDDNDHAPQF 2314
Score = 54.8 bits (126), Expect = 2e-06
Identities = 70/303 (23%), Positives = 127/303 (41%), Gaps = 21/303 (6%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPI-- 124
LVR G G +S+ ++ +ED ND+ P F+ + Y + V E E + L + +
Sbjct: 1345 LVRDG-GFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLE-NQEPEVVYTVLASDMDA 1402
Query: 125 GPSLTIPLTVPRGLTI-FKDIRAFDRDKPNTPNSD----VHYSIVSGNDDGHFALESSHK 179
G + + + G T I + T D ++++V D SS
Sbjct: 1403 GNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSS-- 1460
Query: 180 PVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEI-LFPEPIHAIDQDLGVGATLRYELISG 238
+ L +VLD + F + S R E+ + A+D+D G+ Y ++
Sbjct: 1461 VIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEY-FLTD 1519
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDA--EHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
F++D ++G+L LD +A +H A +Q S+ + +++ +
Sbjct: 1520 EASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVI------IKVYV 1573
Query: 297 LDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDP 356
D+NDN P E + +++ + P + + V A D D G NG + + + FSID
Sbjct: 1574 TDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDK 1633
Query: 357 RSG 359
+G
Sbjct: 1634 YTG 1636
Score = 53.6 bits (123), Expect = 5e-06
Identities = 44/158 (27%), Positives = 72/158 (45%), Gaps = 20/158 (12%)
Query: 218 IHAIDQDLGVGATLRYELISG----NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
+ A D D G+ + Y L G + F +D +G + + +++D + + T+
Sbjct: 79 VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERD----PATYD 134
Query: 274 LQVQASQLNNPLKT----------AQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGF 323
L V+A + T AQA V ++L D+NDN P F Y SI + G
Sbjct: 135 LLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGT 194
Query: 324 SVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSG 359
++ V+ATD+D G G Y+L + F+ID +G
Sbjct: 195 EIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTG 232
Score = 52.8 bits (121), Expect = 9e-06
Identities = 42/166 (25%), Positives = 73/166 (43%), Gaps = 21/166 (12%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ E+ +GT ++ L+A+D D GLNGQ Y E F I+ G
Sbjct: 1487 VREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEA--------------SGAFTIDPMSG 1532
Query: 1000 HVIVARSLPPESEFRLNISALDG-----GNLNDNISVRVFVKDVNDHFPVFKKTWYNFNV 1054
+ + +L E+ + SA+ G+ + + ++V+V DVND+ PV ++ ++ +
Sbjct: 1533 TLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFL 1592
Query: 1055 EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG 1100
T + V A D D G N + + ++T F I TG
Sbjct: 1593 SPESPTNQTTVIVRADDLDLGPNGTVVFSF--AETQSMFSIDKYTG 1636
Score = 52.8 bits (121), Expect = 9e-06
Identities = 98/407 (24%), Positives = 164/407 (40%), Gaps = 51/407 (12%)
Query: 950 IIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPP 1009
+I++ A DLDSGLNG I Y S LS + E F I+ G + L
Sbjct: 1806 VIQVFATDLDSGLNGLIEY----------SILSGNQEEA---FQIDALSGVITTKAILDY 1852
Query: 1010 E--SEFRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLG 1065
E S + L + A D G L++ ++V V D+ND+ P F + + E ++
Sbjct: 1853 ELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPS-EAVEITEDSLPGVIVT 1911
Query: 1066 KVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
V D D +A + F + S+ F I TGV+ + LD E +Y L + D+
Sbjct: 1912 HVSVHDVDL-NSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDS 1970
Query: 1126 GXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKAT 1185
DVNDN P F + + PE+ + SV+ +
Sbjct: 1971 ----VHYTEGALVVRVLDVNDNPPVF--SQDFYQVTVPESIPVG----YSVLTLSA--TD 2018
Query: 1186 IEENAPIGTTVAKVFANDTDF-IGNGNGLILYSLPQ------RKNQQNLGLPSLSSTAIL 1238
+E N I ++ ++ +F I NG I P Q + + +
Sbjct: 2019 LESNENIS---YRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLR 2075
Query: 1239 MVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEH---YENFKMRYYIL 1295
+T+ ++ E + P F + Y L + E+ LV+ + +H EN + Y I+
Sbjct: 2076 ALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSII 2135
Query: 1296 ---NENDTDIRRTFVID----PRNGTLYLVRSPDREVKDTYEVIVRA 1335
++N+ + F + G L L+ S DRE ++E+++ A
Sbjct: 2136 SGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILA 2182
Score = 51.2 bits (117), Expect = 3e-05
Identities = 37/97 (38%), Positives = 50/97 (51%), Gaps = 7/97 (7%)
Query: 750 DVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMD 809
D RMT +A KG +S +V + ED NDN PVF +TY I + ++ GTEI
Sbjct: 143 DEQRMTHLA-LVKGGLSAQAFVRVDL--EDVNDNHPVFNPSTYVTSISDETQPGTEI--I 197
Query: 810 NIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTGV 845
N++ ATD D G Y L G +F +D TG+
Sbjct: 198 NVL-ATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL 233
Score = 50.4 bits (115), Expect = 5e-05
Identities = 57/228 (25%), Positives = 91/228 (39%), Gaps = 34/228 (14%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PE+IP+G +++ L+A DL+S N I Y L + F I+ ++G
Sbjct: 2001 VPESIPVGYSVLTLSATDLES--NENISYRI---------------LSSSKEFSIDPKNG 2043
Query: 1000 HVIVARS---LPPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNV 1054
+ L S + + A DGGN L V + ++D+N++ P F YN ++
Sbjct: 2044 TIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSL 2103
Query: 1055 EEAQYTRRVLGKVDATDADF-GQNANLTYFIQPSDTDLPFEIS----------PLTGVLS 1103
E L D D+ +N + Y I ++ F + G L
Sbjct: 2104 SEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLV 2163
Query: 1104 VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
+ LDRE + L ++A D+G DVNDN P F
Sbjct: 2164 LLHSLDREASASHELVILASDSG-CPPLSSTAVISIQVLDVNDNPPNF 2210
Score = 50.0 bits (114), Expect = 6e-05
Identities = 60/255 (23%), Positives = 107/255 (41%), Gaps = 24/255 (9%)
Query: 224 DLGVGATLRYELISGNDRKLFSLDSVNGSLF-LEKELDLDAEHNLQANTFVLQVQASQLN 282
DL + Y ++S + K FS+D NG++F + L LD +T V+AS
Sbjct: 2018 DLESNENISYRILSSS--KEFSIDPKNGTIFTISPVLLLDT-----ISTTQFLVEASDGG 2070
Query: 283 NPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD-QGENGEF 341
NP A VEI + D+N+ PEF V YN+S+ E+ G +++ D D EN
Sbjct: 2071 NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYV 2130
Query: 342 TYQL--DDPKGAFSIDPR----------SGWLTVRNQTVLDREAHSSLRMKVYAKETN-P 388
Y + + + F ++ + G+L + + LDREA +S + + A ++ P
Sbjct: 2131 EYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHS--LDREASASHELVILASDSGCP 2188
Query: 389 SVVGTFADSQRIAKWRRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVT 448
+ T S ++ P ++ T +G+ + D S +
Sbjct: 2189 PLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYN 2248
Query: 449 LLDANDNNPVFVPSN 463
++ N+ ++ N
Sbjct: 2249 IISGNEKGHFYLEEN 2263
Score = 49.2 bits (112), Expect = 1e-04
Identities = 104/417 (24%), Positives = 157/417 (37%), Gaps = 49/417 (11%)
Query: 982 SADALEVKRYFV-INERHGHVIVARSLP----PESEFRLNISALDGGNLND--NISVRVF 1034
SAD RY + + G I+ +LP + L +SA DGG L N V +
Sbjct: 307 SADGEAAARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIH 366
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFE 1094
+ F++ Y F V E +G V A + + + Y I D F
Sbjct: 367 IFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFS 425
Query: 1095 ISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY-A 1153
I P G + LD ET+ +LTV A+ DVNDN P F
Sbjct: 426 IHPRLGTIRTRKPLDHETQPVVVLTVQAQLG--SAPACSSTEVNITVMDVNDNHPAFLRT 483
Query: 1154 FDEL-LEWKHP--EADELSNHNFESVMMIPVYKATIEENAP----IGTTVAKVFANDTDF 1206
DE+ + P A L+ + + +I P I + +F N +
Sbjct: 484 SDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGS-- 541
Query: 1207 IGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEI 1266
+G G L +L R Q + A+L++TV V ++ E S F Y++E+
Sbjct: 542 LGAGEQREL-TLTLRAEDQGVH----PQAALLVLTV--VIEKREHSPSWTFEHLVYQVEV 594
Query: 1267 EENVNAPVELVSLN---LTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDR 1323
E+++ +++ L +RY + D+ + F I P G +YL R D
Sbjct: 595 SESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAM---FGIRPYTGWIYLRRQFDY 651
Query: 1324 EVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF 1380
E TY V A + ED + V+VR+ D NDNSP F
Sbjct: 652 ESTQTYNFRVFAW--------------IPEDGF--LQNVSTTVIVRVWDENDNSPTF 692
Score = 48.4 bits (110), Expect = 2e-04
Identities = 65/275 (23%), Positives = 114/275 (41%), Gaps = 23/275 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL- 499
S V +T++D NDN+P F+ ++ E + GT + +A D D G+NG++ Y +
Sbjct: 462 SSTEVNITVMDVNDNHPAFLRTS-DEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIA 520
Query: 500 -QRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIE 558
+ I + G++ E L L + A DQ +P + +L V+T+
Sbjct: 521 SPQPGVFAIDRALGVLFLNGSLGAGEQREL----TLTLRAEDQGVHP---QAALLVLTVV 573
Query: 559 VTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGV 618
+ + + + P F Y+ V ++ T + Q + + Q S L + E V
Sbjct: 574 IEK--REHSPSW-TFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS-PLRYSLEPSV 629
Query: 619 P---FAVEERSGVITVVDDLSRYNRPMYDFEAVA-LQENANL-SIVTNATVHVVDVNDER 673
F + +G I + + Y+F A + E+ L ++ T V V D ND
Sbjct: 630 DSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNS 689
Query: 674 GVLLKGAHSPIIFHVKENSA-GAAIGQIFHTNMSS 707
L H + V+E+ IG+I +M S
Sbjct: 690 PTFL---HDVLFLKVEESPVPQGVIGKITAIDMDS 721
Score = 48.0 bits (109), Expect = 3e-04
Identities = 31/97 (31%), Positives = 46/97 (47%)
Query: 1012 EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATD 1071
E R+ AL G L+ VRV ++DVND+ PVF + Y ++ + + V ATD
Sbjct: 144 EQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATD 203
Query: 1072 ADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGEL 1108
D G + Y + P + F I TG+ S E+
Sbjct: 204 QDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEI 240
Score = 46.8 bits (106), Expect = 6e-04
Identities = 32/77 (41%), Positives = 40/77 (51%), Gaps = 4/77 (5%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V L D NDN+PVF PS Y S+ + GT I V A D D G G V Y+L +
Sbjct: 163 VRVDLEDVNDNHPVFNPST-YVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGN- 220
Query: 505 LTITSPFKINPNTGTVS 521
++S F I+ TG S
Sbjct: 221 --VSSLFTIDSTTGLYS 235
Score = 45.6 bits (103), Expect = 0.001
Identities = 48/199 (24%), Positives = 82/199 (41%), Gaps = 15/199 (7%)
Query: 205 GKRIHKEILFPEPIHAI-------DQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEK 257
GK +H ++L +P++ + D D G A + Y + S + F +D+ NG +
Sbjct: 845 GKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTT 904
Query: 258 ELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVE 317
L D ++ + V A+ P QA V I+++ L+ + ++ I E
Sbjct: 905 ILSYD-----YRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPE 959
Query: 318 NL-PNGFSVLQVMATDKDQGENGE--FTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAH 374
NL P L + Q NG+ F+ DD G F ID +G L + + + +H
Sbjct: 960 NLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSH 1019
Query: 375 SSLRMKVYAKETNPSVVGT 393
R+ N S+ T
Sbjct: 1020 YLFRVITTDHSKNLSLSST 1038
Score = 45.2 bits (102), Expect = 0.002
Identities = 40/150 (26%), Positives = 66/150 (44%), Gaps = 15/150 (10%)
Query: 218 IHAIDQDLGVGATLRYELIS--------GNDRKLFSLDSVNGSLFLEKELDLDAEHNLQA 269
I+A+D D G L Y ++S D LF +D + G + ++ LD +
Sbjct: 2336 INALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYE-----NG 2390
Query: 270 NTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVM 329
N + L VQA + + V+IE +D + P F D Y ++ E + + +V
Sbjct: 2391 NKYCLTVQAKDKGDATASLVVWVDIEGIDEFE--PIFTQDQYFFTLPEKNKDRQLIGRVE 2448
Query: 330 ATDKDQGENGEFTYQLDDPKGAFSIDPRSG 359
A+D D G +G Y L FS++ +G
Sbjct: 2449 ASDADAGIDGVILYSLGTSSPFFSVNKTNG 2478
Score = 44.4 bits (100), Expect = 0.003
Identities = 45/177 (25%), Positives = 79/177 (44%), Gaps = 30/177 (16%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN 1287
G+P LS+T ++ V V D+ D P F+ +EI E+ + P +V+ +++ H +
Sbjct: 1868 GMPRLSNTTVIKVQVTDINDNA-----PAFLPSE-AVEITED-SLPGVIVT-HVSVHDVD 1919
Query: 1288 FKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHM 1347
+ +++ F ID G + LV++ D E YE++++ +
Sbjct: 1920 LNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVH------- 1972
Query: 1348 IYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQL 1404
EG +VVR+ DVNDN P F+ + +P + P GY V+ L
Sbjct: 1973 -------YTEGA------LVVRVLDVNDNPPVFSQDFYQV--TVPESIPVGYSVLTL 2014
Score = 41.1 bits (92), Expect = 0.030
Identities = 38/170 (22%), Positives = 72/170 (42%), Gaps = 10/170 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D DLG T+ + + +FS+D G E+ + + LQ++
Sbjct: 1605 VRADDLDLGPNGTVVFSF--AETQSMFSIDKYTG------EIQFQQNPSSEYFPIWLQLK 1656
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
+ P +T + I + + D F Y + EN G S++ V A D +
Sbjct: 1657 VTDQGIPARTTTGLLVIHM-EGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQ 1715
Query: 338 NG-EFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKET 386
+ +++ + G S+ +SG LTV+ LD E + +++ V A+ +
Sbjct: 1716 DSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESS 1765
Score = 39.1 bits (87), Expect = 0.12
Identities = 19/40 (47%), Positives = 24/40 (60%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKEL 259
A DQD G+ T+ YELI GN LF++DS G E E+
Sbjct: 201 ATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEI 240
Score = 39.1 bits (87), Expect = 0.12
Identities = 44/184 (23%), Positives = 76/184 (41%), Gaps = 9/184 (4%)
Query: 732 IAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
I +G I+ PL + + V A+ G+ + VTI+I P FE
Sbjct: 323 ILGEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINA-DVTIHIFQTTLAPAEFERPK 381
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD 851
Y + E+ + I +KA + + +F G+ F + G ++
Sbjct: 382 YTFLVYEDVPEDSPI---GTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIR-TRK 437
Query: 852 SLDREKKIMYKLSLVAR-DTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKL 910
LD E + + L++ A+ + S E+ I + D NDN P F + + ++RI + T
Sbjct: 438 PLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAF--LRTSDEIRISQTTP- 494
Query: 911 NGTA 914
GTA
Sbjct: 495 PGTA 498
Score = 38.3 bits (85), Expect = 0.21
Identities = 17/43 (39%), Positives = 25/43 (58%)
Query: 1441 ATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARDA 1483
A D D G+N Y + +E + F IDP+SGT++ L R+A
Sbjct: 1502 AVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREA 1544
Score = 37.9 bits (84), Expect = 0.28
Identities = 30/101 (29%), Positives = 48/101 (47%), Gaps = 19/101 (18%)
Query: 812 IKATDADEGTNALFMYTLFG-----EGKEMFDVDENTGVVKFIGDSLDREKK-IMYKLSL 865
+ A+DAD G Y+L+ E + F +D + G + + +DRE+ Y L +
Sbjct: 79 VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQI-CVSQDIDRERDPATYDLLV 137
Query: 866 VARD------------TGGLSSEAELIIMIGDENDNKPEFN 894
A+D GGLS++A + + + D NDN P FN
Sbjct: 138 EAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFN 178
Score = 37.1 bits (82), Expect = 0.48
Identities = 31/113 (27%), Positives = 54/113 (47%), Gaps = 8/113 (7%)
Query: 436 DEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMV 495
+++ SF V V++LD ND+ P F+ S+ + + N + + I + A+D D G G +
Sbjct: 2291 EKKHFSFAVVFVSVLDDNDHAPQFMFSS-FSCIVPENLPISSTICSINALDFDAGPYGEL 2349
Query: 496 LYDLQRTSNLTITSP-----FKINPNTGTVSVAESPILE--GRHALFVEASDQ 541
Y + LT F I+P TG + + E ++ L V+A D+
Sbjct: 2350 TYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDK 2402
Score = 35.9 bits (79), Expect = 1.1
Identities = 17/36 (47%), Positives = 24/36 (66%), Gaps = 1/36 (2%)
Query: 156 NSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYD 191
N +H+SIV+ + DGHF ++SS L L K LDY+
Sbjct: 981 NGKLHFSIVADDKDGHFEIDSSTGD-LFLSKELDYE 1015
Score = 35.5 bits (78), Expect = 1.5
Identities = 23/88 (26%), Positives = 44/88 (50%), Gaps = 7/88 (7%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V + ++ P+F Y F++ K +IG+V+A D D G +G++LY L +S
Sbjct: 2411 VWVDIEGIDEFEPIFTQDQ-YFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLGTSSP 2469
Query: 505 LTITSPFKINPNTGTVSVAES-PILEGR 531
F +N G + + + P+++ +
Sbjct: 2470 F-----FSVNKTNGNIYLIRALPLIKSQ 2492
Score = 34.3 bits (75), Expect = 3.4
Identities = 20/71 (28%), Positives = 35/71 (49%), Gaps = 2/71 (2%)
Query: 45 DSDSPQNVVKFRLGCDFDEGDD--LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPY 102
D D ++ + L + +GD+ + + +SA V V +EDVNDN P+F + Y
Sbjct: 123 DIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTY 182
Query: 103 HVTVDELTPTG 113
++ + T G
Sbjct: 183 VTSISDETQPG 193
Score = 33.9 bits (74), Expect = 4.5
Identities = 51/243 (20%), Positives = 95/243 (39%), Gaps = 24/243 (9%)
Query: 79 AYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGE-----KAFIFLIAPIGP---SLTI 130
++ V V + D ND+ P F+ + + V E P A F P G S+
Sbjct: 2296 SFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVS 2355
Query: 131 PLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGH---FALESSHKPVLLLRKV 187
P + G++ D+ D P T D+H + ++G+ +++ K V
Sbjct: 2356 PCFLTHGMSYDHDLFLID---PLT--GDIHAKQILDYENGNKYCLTVQAKDKGDATASLV 2410
Query: 188 LDYDA-GDKEFQLVIMASG-----KRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDR 241
+ D G EF+ + +K+ + A D D G+ + Y L G
Sbjct: 2411 VWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL--GTSS 2468
Query: 242 KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLND 301
FS++ NG+++L + L L + +T +++ A + K A V + + ++
Sbjct: 2469 PFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSE 2528
Query: 302 NLP 304
P
Sbjct: 2529 GTP 2531
Score = 33.5 bits (73), Expect = 6.0
Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 2/63 (3%)
Query: 144 IRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMA 203
I+ F D + N + YSI+SGN + F +++ V+ + +LDY+ + L++ A
Sbjct: 1807 IQVFATDLDSGLNGLIEYSILSGNQEEAFQIDAL-SGVITTKAILDYEL-TSSYSLIVQA 1864
Query: 204 SGK 206
+ K
Sbjct: 1865 TDK 1867
>AF152519-1|AAD43779.1| 814|Homo sapiens protocadherin gamma B3
short form protein protein.
Length = 814
Score = 121 bits (292), Expect = 2e-26
Identities = 130/489 (26%), Positives = 211/489 (43%), Gaps = 47/489 (9%)
Query: 424 KVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVK 483
K T E E+ ++F +V V + D NDN P F N+ E + A G
Sbjct: 98 KKSTCVLEFEMVAEKPLNFFHVTVLIQDINDNPPTF-SQNITELEISELALTGATFALES 156
Query: 484 AVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASD 540
A DPD+G N + Y L + ++ ++ + V ++P+ + H L + A D
Sbjct: 157 AQDPDVGVNSLQQYYLSPDPHFSLIQKENLDGSRYPELVLKAPLDREEQPHHHLVLTAVD 216
Query: 541 QPANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA 600
PS I V + P P F Y V N+ G+SV ++ D
Sbjct: 217 G-GEPSRS----CTTQIRVIVADANDNP--PVFTQDMYRVNVAENLPAGSSVLKVMAIDM 269
Query: 601 FE--QNDVSYDLLH-GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLS 657
E ++ Y ++ G E F ++ ++G +T + +L R Y V ++ + +
Sbjct: 270 DEGINAEIIYAFINIGKEVRQLFKLDSKTGELTTIGELDFEERDSYTI-GVEAKDGGHHT 328
Query: 658 IVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGT--- 713
+ + D ND + + S H++E++ G A+ I ++ S + NG
Sbjct: 329 AYCKVQIDISDENDNAPEITLASESQ---HIQEDAELGTAVALIKTHDLDSGF-NGEILC 384
Query: 714 ---GNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGI 770
GN F I QD + + DG LDRE+ Y +T+ A +KG +
Sbjct: 385 QLKGNFPFKIV--QDTKNTYRLVTDGA------LDREQIPEYNVTITAT-DKGNPPLSSS 435
Query: 771 YQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF 830
+T++I D NDN PVF A+Y + EN+ G I ++A+D D G N L Y +
Sbjct: 436 KTITLHILDVNDNVPVFHQASYTVHVAENNPPGASIAH---VRASDPDLGPNGLVSYYIV 492
Query: 831 G---EGKEM---FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIM 882
E +E+ V +GVV F + D E+ ++L+L ARD G LS+ L ++
Sbjct: 493 ASDLEPRELSSYVSVSARSGVV-FAQRAFDHEQLRAFELTLQARDQGSPTLSANVSLRVL 551
Query: 883 IGDENDNKP 891
+ D NDN P
Sbjct: 552 VDDRNDNAP 560
Score = 90.6 bits (215), Expect = 4e-17
Identities = 55/164 (33%), Positives = 86/164 (52%), Gaps = 8/164 (4%)
Query: 743 PLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKI 802
PLDRE++ + + V+ + G S + Q+ + + D NDNPPVF Y + EN
Sbjct: 199 PLDREEQPHHHL-VLTAVDGGEPSRSCTTQIRVIVADANDNPPVFTQDMYRVNVAENLPA 257
Query: 803 GTEIKMDNIIKATDADEGTNALFMYTLFGEGKE---MFDVDENTGVVKFIGDSLDREKKI 859
G+ + + A D DEG NA +Y GKE +F +D TG + IG+ LD E++
Sbjct: 258 GSSVLK---VMAIDMDEGINAEIIYAFINIGKEVRQLFKLDSKTGELTTIGE-LDFEERD 313
Query: 860 MYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVR 903
Y + + A+D G ++ ++ I I DENDN PE E+ ++
Sbjct: 314 SYTIGVEAKDGGHHTAYCKVQIDISDENDNAPEITLASESQHIQ 357
Score = 79.4 bits (187), Expect = 9e-14
Identities = 52/170 (30%), Positives = 84/170 (49%), Gaps = 7/170 (4%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D+GV + +Y L L ++++GS + E L + Q + ++ + A
Sbjct: 157 AQDPDVGVNSLQQYYLSPDPHFSLIQKENLDGSRYPELVLKAPLDREEQPHHHLV-LTAV 215
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
P ++ ++ + + D NDN P F D Y +++ ENLP G SVL+VMA D D+G N
Sbjct: 216 DGGEPSRSCTTQIRVIVADANDNPPVFTQDMYRVNVAENLPAGSSVLKVMAIDMDEGINA 275
Query: 340 EFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
E Y + + F +D ++G LT + LD E S + V AK+
Sbjct: 276 EIIYAFINIGKEVRQLFKLDSKTGELTTIGE--LDFEERDSYTIGVEAKD 323
Score = 78.6 bits (185), Expect = 2e-13
Identities = 106/414 (25%), Positives = 177/414 (42%), Gaps = 47/414 (11%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G T +A D D G+N +Y + + + S + + L+ RY +++
Sbjct: 149 GATFALESAQDPDVGVNSLQQYYLSPDPHF--SLIQKENLDGSRY-------PELVLKAP 199
Query: 1007 LPPESE--FRLNISALDGGNLNDNIS--VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRR 1062
L E + L ++A+DGG + + + +RV V D ND+ PVF + Y NV E
Sbjct: 200 LDREEQPHHHLVLTAVDGGEPSRSCTTQIRVIVADANDNPPVFTQDMYRVNVAENLPAGS 259
Query: 1063 VLGKVDATDADFGQNANLTY-FIQ-PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTV 1120
+ KV A D D G NA + Y FI + F++ TG L+ GELD E D Y + V
Sbjct: 260 SVLKVMAIDMDEGINAEIIYAFINIGKEVRQLFKLDSKTGELTTIGELDFEERDSYTIGV 319
Query: 1121 VARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE--------LSNHN 1172
A+D G D NDN+P+ E +H + D + H+
Sbjct: 320 EAKDGG---HHTAYCKVQIDISDENDNAPEITLASES---QHIQEDAELGTAVALIKTHD 373
Query: 1173 FESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRK---NQQNLGL 1229
+S + ++ N P + + N + +G L +P+ + G
Sbjct: 374 LDSGFNGEIL-CQLKGNFPF--KIVQDTKNTYRLVTDG-ALDREQIPEYNVTITATDKGN 429
Query: 1230 PSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSLNLTEHYEN 1287
P LSS+ + + + DV D V PVF Y + + EN A + V + + N
Sbjct: 430 PPLSSSKTITLHILDVNDNV-----PVFHQASYTVHVAENNPPGASIAHVRASDPDLGPN 484
Query: 1288 FKMRYYILNENDTDIRR--TFV-IDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
+ YYI+ +D + R ++V + R+G ++ R+ D E +E+ ++A Q
Sbjct: 485 GLVSYYIV-ASDLEPRELSSYVSVSARSGVVFAQRAFDHEQLRAFELTLQARDQ 537
Score = 77.0 bits (181), Expect = 5e-13
Identities = 73/264 (27%), Positives = 115/264 (43%), Gaps = 24/264 (9%)
Query: 897 EENSKVRIHRETKLNG--TAGFTI-IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKL 953
EE I E K G TA + I++ +N A ++ I E+ +GT + +
Sbjct: 310 EERDSYTIGVEAKDGGHHTAYCKVQIDISDENDNAPEITLASESQHIQEDAELGTAVALI 369
Query: 954 NALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEF 1013
DLDSG NG+I + P K+ D Y ++ + + +P E+
Sbjct: 370 KTHDLDSGFNGEILCQLKGNF---PFKIVQDTKNT--YRLVTDG---ALDREQIP---EY 418
Query: 1014 RLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATD 1071
+ I+A D GN L+ + ++ + + DVND+ PVF + Y +V E + V A+D
Sbjct: 419 NVTITATDKGNPPLSSSKTITLHILDVNDNVPVFHQASYTVHVAENNPPGASIAHVRASD 478
Query: 1072 ADFGQNANLTYFIQPSDTDLPFE------ISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
D G N ++Y+I SD + P E +S +GV+ D E + LT+ ARD
Sbjct: 479 PDLGPNGLVSYYIVASDLE-PRELSSYVSVSARSGVVFAQRAFDHEQLRAFELTLQARDQ 537
Query: 1126 GXXXXXXXXXXXXXXXXDVNDNSP 1149
G D NDN+P
Sbjct: 538 G-SPTLSANVSLRVLVDDRNDNAP 560
Score = 74.9 bits (176), Expect = 2e-12
Identities = 76/324 (23%), Positives = 131/324 (40%), Gaps = 18/324 (5%)
Query: 31 HVSVILAQSIDSLVDSDSPQNVVKFRLGCDFDEGDDLV--RIGAGLNQISAYLSVTVYIE 88
H S+I +++D S P+ V+K L + LV + G S + V +
Sbjct: 177 HFSLIQKENLDG---SRYPELVLKAPLDREEQPHHHLVLTAVDGGEPSRSCTTQIRVIVA 233
Query: 89 DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIFKDIRA-F 147
D NDN P+F Y V V E P G + + + + + + I K++R F
Sbjct: 234 DANDNPPVFTQDMYRVNVAENLPAGSSVLKVMAIDMDEGINAEI-IYAFINIGKEVRQLF 292
Query: 148 DRDKPN---TPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
D T ++ + G A + H ++ D D ++ + +
Sbjct: 293 KLDSKTGELTTIGELDFEERDSYTIGVEAKDGGHHTAYCKVQIDISDENDNAPEITLASE 352
Query: 205 GKRIHKEILFPEPIHAI---DQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDL 261
+ I ++ + I D D G + +L GN D+ N + L + L
Sbjct: 353 SQHIQEDAELGTAVALIKTHDLDSGFNGEILCQL-KGNFPFKIVQDTKN-TYRLVTDGAL 410
Query: 262 DAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN 321
D E Q + + + A+ NP ++ + + +LD+NDN+P F Y + + EN P
Sbjct: 411 DRE---QIPEYNVTITATDKGNPPLSSSKTITLHILDVNDNVPVFHQASYTVHVAENNPP 467
Query: 322 GFSVLQVMATDKDQGENGEFTYQL 345
G S+ V A+D D G NG +Y +
Sbjct: 468 GASIAHVRASDPDLGPNGLVSYYI 491
Score = 72.5 bits (170), Expect = 1e-11
Identities = 57/218 (26%), Positives = 99/218 (45%), Gaps = 20/218 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN+P G++++K+ A+D+D G+N +I Y F I K EV++ F ++ + G
Sbjct: 251 VAENLPAGSSVLKVMAIDMDEGINAEIIYAF-----INIGK------EVRQLFKLDSKTG 299
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ L E + + + A DGG+ V++ + D ND+ P + +++E
Sbjct: 300 ELTTIGELDFEERDSYTIGVEAKDGGHHTAYCKVQIDISDENDNAPEITLASESQHIQED 359
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI---SPLTGVLSVNGELDRETED 1114
+ + D D G N + ++ + PF+I + T L +G LDRE
Sbjct: 360 AELGTAVALIKTHDLDSGFNGEILCQLK---GNFPFKIVQDTKNTYRLVTDGALDREQIP 416
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY 1152
+Y +T+ A D G DVNDN P F+
Sbjct: 417 EYNVTITATDKG-NPPLSSSKTITLHILDVNDNVPVFH 453
Score = 69.7 bits (163), Expect = 7e-11
Identities = 76/286 (26%), Positives = 126/286 (44%), Gaps = 25/286 (8%)
Query: 683 PIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQ 741
PI + + E G+ +G + + T N+R +IA ++ T E+G +
Sbjct: 32 PIRYAIPEELDRGSLVGNLAKDLGFGVGDLPTRNLR-VIAEKKFFT---VSPENGNLLVS 87
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
+DRE+ + T + EF + VT+ I+D NDNPP F E I E +
Sbjct: 88 DRIDREEICGKKSTCVLEFEMVAEKPLNFFHVTVLIQDINDNPPTFSQNITELEISELAL 147
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----IGDSLDREK 857
G +++ A D D G N+L Y L + EN ++ + LDRE+
Sbjct: 148 TGATFALES---AQDPDVGVNSLQQYYLSPDPHFSLIQKENLDGSRYPELVLKAPLDREE 204
Query: 858 KIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAG 915
+ + L L A D G S ++ +++ D NDN P F Q + +V + N AG
Sbjct: 205 QPHHHLVLTAVDGGEPSRSCTTQIRVIVADANDNPPVFTQ--DMYRVNVAE----NLPAG 258
Query: 916 FTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSG 961
++++V A+D+D+ +I I IG + +L LD +G
Sbjct: 259 SSVLKV-----MAIDMDEGINAEIIYAFINIGKEVRQLFKLDSKTG 299
Score = 69.3 bits (162), Expect = 1e-10
Identities = 77/268 (28%), Positives = 122/268 (45%), Gaps = 20/268 (7%)
Query: 635 LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKEN-S 692
L R +P + A+ + S T V V D ND V + + +V EN
Sbjct: 200 LDREEQPHHHLVLTAVDGGEPSRSCTTQIRVIVADANDNPPVFTQDMYR---VNVAENLP 256
Query: 693 AGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDV 751
AG+++ ++ +M G + I ++V + ++ G + T LD E+RD
Sbjct: 257 AGSSVLKVMAIDMDE--GINAEIIYAFINIGKEVRQLFKLDSKTGELTTIGELDFEERDS 314
Query: 752 YRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNI 811
Y T+ E G A +V I I DENDN P A+ I E++++GT + +
Sbjct: 315 Y--TIGVEAKDGGHHTA-YCKVQIDISDENDNAPEITLASESQHIQEDAELGTAVAL--- 368
Query: 812 IKATDADEGTNALFMYTLFGEGKEMFDVDENT-GVVKFIGD-SLDREKKIMYKLSLVARD 869
IK D D G N + L +G F + ++T + + D +LDRE+ Y +++ A D
Sbjct: 369 IKTHDLDSGFNGEILCQL--KGNFPFKIVQDTKNTYRLVTDGALDREQIPEYNVTITATD 426
Query: 870 TGG--LSSEAELIIMIGDENDNKPEFNQ 895
G LSS + + I D NDN P F+Q
Sbjct: 427 KGNPPLSSSKTITLHILDVNDNVPVFHQ 454
Score = 61.7 bits (143), Expect = 2e-08
Identities = 66/200 (33%), Positives = 93/200 (46%), Gaps = 23/200 (11%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN P G +I + A D D G NG + Y YI S L + E+ Y ++ R G
Sbjct: 461 VAENNPPGASIAHVRASDPDLGPNGLVSY------YIVASDL--EPRELSSYVSVSARSG 512
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYN---- 1051
V R+ E F L + A D G+ L+ N+S+RV V D ND+ P+
Sbjct: 513 VVFAQRAFDHEQLRAFELTLQARDQGSPTLSANVSLRVLVDDRNDNAPLVLYPALGPEGS 572
Query: 1052 --FN-VEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSDTDLPFEISPLTGVLSVNGE 1107
F+ V + ++ KV A DAD G NA L+Y +Q S+ L F + TG +
Sbjct: 573 ALFDMVPRSAEPGYLVTKVVAVDADSGYNAWLSYHIVQASEPGL-FSLGLRTGEVRTART 631
Query: 1108 L-DRETEDKYILTVVARDNG 1126
L DRE + +L V RD G
Sbjct: 632 LGDREAARQRLL-VTVRDGG 650
Score = 47.6 bits (108), Expect = 3e-04
Identities = 49/206 (23%), Positives = 81/206 (39%), Gaps = 14/206 (6%)
Query: 957 DLDSG-LNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE----- 1010
+LD G L G + + V P++ + + K++F ++ +G+++V+ + E
Sbjct: 40 ELDRGSLVGNLAKDLGFGVGDLPTR-NLRVIAEKKFFTVSPENGNLLVSDRIDREEICGK 98
Query: 1011 -SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
S L + LN V V ++D+ND+ P F + + E T A
Sbjct: 99 KSTCVLEFEMVAEKPLNF-FHVTVLIQDINDNPPTFSQNITELEISELALTGATFALESA 157
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTG----VLSVNGELDRETEDKYILTVVARDN 1125
D D G N+ Y++ P + L G L + LDRE + + L + A D
Sbjct: 158 QDPDVGVNSLQQYYLSPDPHFSLIQKENLDGSRYPELVLKAPLDREEQPHHHLVLTAVDG 217
Query: 1126 GXXXXXXXXXXXXXXXXDVNDNSPKF 1151
G D NDN P F
Sbjct: 218 G-EPSRSCTTQIRVIVADANDNPPVF 242
Score = 39.1 bits (87), Expect = 0.12
Identities = 39/135 (28%), Positives = 57/135 (42%), Gaps = 5/135 (3%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D GVG L ++K F++ NG+L + +D + E + +T VL+ +
Sbjct: 51 AKDLGFGVGDLPTRNLRVIAEKKFFTVSPENGNLLVSDRIDRE-EICGKKSTCVLEFEMV 109
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
PL V I+ D+NDN P F + + I E G + A D D G N
Sbjct: 110 A-EKPLNFFHVTVLIQ--DINDNPPTFSQNITELEISELALTGATFALESAQDPDVGVNS 166
Query: 340 EFTYQLDDPKGAFSI 354
Y L P FS+
Sbjct: 167 LQQYYL-SPDPHFSL 180
Score = 33.9 bits (74), Expect = 4.5
Identities = 28/93 (30%), Positives = 44/93 (47%), Gaps = 9/93 (9%)
Query: 439 LMSFVNVEVTLLDANDNNPVFV-----PSNLYEFSM-KSNAKVGTVIGKVKAVDPDLGQN 492
L + V++ V + D NDN P+ + P F M +A+ G ++ KV AVD D G N
Sbjct: 542 LSANVSLRVLVDDRNDNAPLVLYPALGPEGSALFDMVPRSAEPGYLVTKVVAVDADSGYN 601
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAES 525
+ Y + + S + F + TG V A +
Sbjct: 602 AWLSYHIVQASEPGL---FSLGLRTGEVRTART 631
>AF152332-1|AAD43726.1| 929|Homo sapiens protocadherin gamma B3
protein.
Length = 929
Score = 121 bits (292), Expect = 2e-26
Identities = 130/489 (26%), Positives = 211/489 (43%), Gaps = 47/489 (9%)
Query: 424 KVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVK 483
K T E E+ ++F +V V + D NDN P F N+ E + A G
Sbjct: 98 KKSTCVLEFEMVAEKPLNFFHVTVLIQDINDNPPTF-SQNITELEISELALTGATFALES 156
Query: 484 AVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASD 540
A DPD+G N + Y L + ++ ++ + V ++P+ + H L + A D
Sbjct: 157 AQDPDVGVNSLQQYYLSPDPHFSLIQKENLDGSRYPELVLKAPLDREEQPHHHLVLTAVD 216
Query: 541 QPANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA 600
PS I V + P P F Y V N+ G+SV ++ D
Sbjct: 217 G-GEPSRS----CTTQIRVIVADANDNP--PVFTQDMYRVNVAENLPAGSSVLKVMAIDM 269
Query: 601 FE--QNDVSYDLLH-GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLS 657
E ++ Y ++ G E F ++ ++G +T + +L R Y V ++ + +
Sbjct: 270 DEGINAEIIYAFINIGKEVRQLFKLDSKTGELTTIGELDFEERDSYTI-GVEAKDGGHHT 328
Query: 658 IVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGT--- 713
+ + D ND + + S H++E++ G A+ I ++ S + NG
Sbjct: 329 AYCKVQIDISDENDNAPEITLASESQ---HIQEDAELGTAVALIKTHDLDSGF-NGEILC 384
Query: 714 ---GNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGI 770
GN F I QD + + DG LDRE+ Y +T+ A +KG +
Sbjct: 385 QLKGNFPFKIV--QDTKNTYRLVTDGA------LDREQIPEYNVTITAT-DKGNPPLSSS 435
Query: 771 YQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF 830
+T++I D NDN PVF A+Y + EN+ G I ++A+D D G N L Y +
Sbjct: 436 KTITLHILDVNDNVPVFHQASYTVHVAENNPPGASIAH---VRASDPDLGPNGLVSYYIV 492
Query: 831 G---EGKEM---FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIM 882
E +E+ V +GVV F + D E+ ++L+L ARD G LS+ L ++
Sbjct: 493 ASDLEPRELSSYVSVSARSGVV-FAQRAFDHEQLRAFELTLQARDQGSPTLSANVSLRVL 551
Query: 883 IGDENDNKP 891
+ D NDN P
Sbjct: 552 VDDRNDNAP 560
Score = 90.6 bits (215), Expect = 4e-17
Identities = 55/164 (33%), Positives = 86/164 (52%), Gaps = 8/164 (4%)
Query: 743 PLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKI 802
PLDRE++ + + V+ + G S + Q+ + + D NDNPPVF Y + EN
Sbjct: 199 PLDREEQPHHHL-VLTAVDGGEPSRSCTTQIRVIVADANDNPPVFTQDMYRVNVAENLPA 257
Query: 803 GTEIKMDNIIKATDADEGTNALFMYTLFGEGKE---MFDVDENTGVVKFIGDSLDREKKI 859
G+ + + A D DEG NA +Y GKE +F +D TG + IG+ LD E++
Sbjct: 258 GSSVLK---VMAIDMDEGINAEIIYAFINIGKEVRQLFKLDSKTGELTTIGE-LDFEERD 313
Query: 860 MYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVR 903
Y + + A+D G ++ ++ I I DENDN PE E+ ++
Sbjct: 314 SYTIGVEAKDGGHHTAYCKVQIDISDENDNAPEITLASESQHIQ 357
Score = 79.4 bits (187), Expect = 9e-14
Identities = 52/170 (30%), Positives = 84/170 (49%), Gaps = 7/170 (4%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D+GV + +Y L L ++++GS + E L + Q + ++ + A
Sbjct: 157 AQDPDVGVNSLQQYYLSPDPHFSLIQKENLDGSRYPELVLKAPLDREEQPHHHLV-LTAV 215
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
P ++ ++ + + D NDN P F D Y +++ ENLP G SVL+VMA D D+G N
Sbjct: 216 DGGEPSRSCTTQIRVIVADANDNPPVFTQDMYRVNVAENLPAGSSVLKVMAIDMDEGINA 275
Query: 340 EFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
E Y + + F +D ++G LT + LD E S + V AK+
Sbjct: 276 EIIYAFINIGKEVRQLFKLDSKTGELTTIGE--LDFEERDSYTIGVEAKD 323
Score = 78.6 bits (185), Expect = 2e-13
Identities = 106/414 (25%), Positives = 177/414 (42%), Gaps = 47/414 (11%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
G T +A D D G+N +Y + + + S + + L+ RY +++
Sbjct: 149 GATFALESAQDPDVGVNSLQQYYLSPDPHF--SLIQKENLDGSRY-------PELVLKAP 199
Query: 1007 LPPESE--FRLNISALDGGNLNDNIS--VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRR 1062
L E + L ++A+DGG + + + +RV V D ND+ PVF + Y NV E
Sbjct: 200 LDREEQPHHHLVLTAVDGGEPSRSCTTQIRVIVADANDNPPVFTQDMYRVNVAENLPAGS 259
Query: 1063 VLGKVDATDADFGQNANLTY-FIQ-PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTV 1120
+ KV A D D G NA + Y FI + F++ TG L+ GELD E D Y + V
Sbjct: 260 SVLKVMAIDMDEGINAEIIYAFINIGKEVRQLFKLDSKTGELTTIGELDFEERDSYTIGV 319
Query: 1121 VARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE--------LSNHN 1172
A+D G D NDN+P+ E +H + D + H+
Sbjct: 320 EAKDGG---HHTAYCKVQIDISDENDNAPEITLASES---QHIQEDAELGTAVALIKTHD 373
Query: 1173 FESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRK---NQQNLGL 1229
+S + ++ N P + + N + +G L +P+ + G
Sbjct: 374 LDSGFNGEIL-CQLKGNFPF--KIVQDTKNTYRLVTDG-ALDREQIPEYNVTITATDKGN 429
Query: 1230 PSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSLNLTEHYEN 1287
P LSS+ + + + DV D V PVF Y + + EN A + V + + N
Sbjct: 430 PPLSSSKTITLHILDVNDNV-----PVFHQASYTVHVAENNPPGASIAHVRASDPDLGPN 484
Query: 1288 FKMRYYILNENDTDIRR--TFV-IDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
+ YYI+ +D + R ++V + R+G ++ R+ D E +E+ ++A Q
Sbjct: 485 GLVSYYIV-ASDLEPRELSSYVSVSARSGVVFAQRAFDHEQLRAFELTLQARDQ 537
Score = 77.0 bits (181), Expect = 5e-13
Identities = 73/264 (27%), Positives = 115/264 (43%), Gaps = 24/264 (9%)
Query: 897 EENSKVRIHRETKLNG--TAGFTI-IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKL 953
EE I E K G TA + I++ +N A ++ I E+ +GT + +
Sbjct: 310 EERDSYTIGVEAKDGGHHTAYCKVQIDISDENDNAPEITLASESQHIQEDAELGTAVALI 369
Query: 954 NALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEF 1013
DLDSG NG+I + P K+ D Y ++ + + +P E+
Sbjct: 370 KTHDLDSGFNGEILCQLKGNF---PFKIVQDTKNT--YRLVTDG---ALDREQIP---EY 418
Query: 1014 RLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATD 1071
+ I+A D GN L+ + ++ + + DVND+ PVF + Y +V E + V A+D
Sbjct: 419 NVTITATDKGNPPLSSSKTITLHILDVNDNVPVFHQASYTVHVAENNPPGASIAHVRASD 478
Query: 1072 ADFGQNANLTYFIQPSDTDLPFE------ISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
D G N ++Y+I SD + P E +S +GV+ D E + LT+ ARD
Sbjct: 479 PDLGPNGLVSYYIVASDLE-PRELSSYVSVSARSGVVFAQRAFDHEQLRAFELTLQARDQ 537
Query: 1126 GXXXXXXXXXXXXXXXXDVNDNSP 1149
G D NDN+P
Sbjct: 538 G-SPTLSANVSLRVLVDDRNDNAP 560
Score = 74.9 bits (176), Expect = 2e-12
Identities = 76/324 (23%), Positives = 131/324 (40%), Gaps = 18/324 (5%)
Query: 31 HVSVILAQSIDSLVDSDSPQNVVKFRLGCDFDEGDDLV--RIGAGLNQISAYLSVTVYIE 88
H S+I +++D S P+ V+K L + LV + G S + V +
Sbjct: 177 HFSLIQKENLDG---SRYPELVLKAPLDREEQPHHHLVLTAVDGGEPSRSCTTQIRVIVA 233
Query: 89 DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIFKDIRA-F 147
D NDN P+F Y V V E P G + + + + + + I K++R F
Sbjct: 234 DANDNPPVFTQDMYRVNVAENLPAGSSVLKVMAIDMDEGINAEI-IYAFINIGKEVRQLF 292
Query: 148 DRDKPN---TPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMAS 204
D T ++ + G A + H ++ D D ++ + +
Sbjct: 293 KLDSKTGELTTIGELDFEERDSYTIGVEAKDGGHHTAYCKVQIDISDENDNAPEITLASE 352
Query: 205 GKRIHKEILFPEPIHAI---DQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDL 261
+ I ++ + I D D G + +L GN D+ N + L + L
Sbjct: 353 SQHIQEDAELGTAVALIKTHDLDSGFNGEILCQL-KGNFPFKIVQDTKN-TYRLVTDGAL 410
Query: 262 DAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN 321
D E Q + + + A+ NP ++ + + +LD+NDN+P F Y + + EN P
Sbjct: 411 DRE---QIPEYNVTITATDKGNPPLSSSKTITLHILDVNDNVPVFHQASYTVHVAENNPP 467
Query: 322 GFSVLQVMATDKDQGENGEFTYQL 345
G S+ V A+D D G NG +Y +
Sbjct: 468 GASIAHVRASDPDLGPNGLVSYYI 491
Score = 72.5 bits (170), Expect = 1e-11
Identities = 57/218 (26%), Positives = 99/218 (45%), Gaps = 20/218 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN+P G++++K+ A+D+D G+N +I Y F I K EV++ F ++ + G
Sbjct: 251 VAENLPAGSSVLKVMAIDMDEGINAEIIYAF-----INIGK------EVRQLFKLDSKTG 299
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ L E + + + A DGG+ V++ + D ND+ P + +++E
Sbjct: 300 ELTTIGELDFEERDSYTIGVEAKDGGHHTAYCKVQIDISDENDNAPEITLASESQHIQED 359
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI---SPLTGVLSVNGELDRETED 1114
+ + D D G N + ++ + PF+I + T L +G LDRE
Sbjct: 360 AELGTAVALIKTHDLDSGFNGEILCQLK---GNFPFKIVQDTKNTYRLVTDGALDREQIP 416
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY 1152
+Y +T+ A D G DVNDN P F+
Sbjct: 417 EYNVTITATDKG-NPPLSSSKTITLHILDVNDNVPVFH 453
Score = 69.7 bits (163), Expect = 7e-11
Identities = 76/286 (26%), Positives = 126/286 (44%), Gaps = 25/286 (8%)
Query: 683 PIIFHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQ 741
PI + + E G+ +G + + T N+R +IA ++ T E+G +
Sbjct: 32 PIRYAIPEELDRGSLVGNLAKDLGFGVGDLPTRNLR-VIAEKKFFT---VSPENGNLLVS 87
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
+DRE+ + T + EF + VT+ I+D NDNPP F E I E +
Sbjct: 88 DRIDREEICGKKSTCVLEFEMVAEKPLNFFHVTVLIQDINDNPPTFSQNITELEISELAL 147
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----IGDSLDREK 857
G +++ A D D G N+L Y L + EN ++ + LDRE+
Sbjct: 148 TGATFALES---AQDPDVGVNSLQQYYLSPDPHFSLIQKENLDGSRYPELVLKAPLDREE 204
Query: 858 KIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAG 915
+ + L L A D G S ++ +++ D NDN P F Q + +V + N AG
Sbjct: 205 QPHHHLVLTAVDGGEPSRSCTTQIRVIVADANDNPPVFTQ--DMYRVNVAE----NLPAG 258
Query: 916 FTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSG 961
++++V A+D+D+ +I I IG + +L LD +G
Sbjct: 259 SSVLKV-----MAIDMDEGINAEIIYAFINIGKEVRQLFKLDSKTG 299
Score = 69.3 bits (162), Expect = 1e-10
Identities = 77/268 (28%), Positives = 122/268 (45%), Gaps = 20/268 (7%)
Query: 635 LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKEN-S 692
L R +P + A+ + S T V V D ND V + + +V EN
Sbjct: 200 LDREEQPHHHLVLTAVDGGEPSRSCTTQIRVIVADANDNPPVFTQDMYR---VNVAENLP 256
Query: 693 AGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDV 751
AG+++ ++ +M G + I ++V + ++ G + T LD E+RD
Sbjct: 257 AGSSVLKVMAIDMDE--GINAEIIYAFINIGKEVRQLFKLDSKTGELTTIGELDFEERDS 314
Query: 752 YRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNI 811
Y T+ E G A +V I I DENDN P A+ I E++++GT + +
Sbjct: 315 Y--TIGVEAKDGGHHTA-YCKVQIDISDENDNAPEITLASESQHIQEDAELGTAVAL--- 368
Query: 812 IKATDADEGTNALFMYTLFGEGKEMFDVDENT-GVVKFIGD-SLDREKKIMYKLSLVARD 869
IK D D G N + L +G F + ++T + + D +LDRE+ Y +++ A D
Sbjct: 369 IKTHDLDSGFNGEILCQL--KGNFPFKIVQDTKNTYRLVTDGALDREQIPEYNVTITATD 426
Query: 870 TGG--LSSEAELIIMIGDENDNKPEFNQ 895
G LSS + + I D NDN P F+Q
Sbjct: 427 KGNPPLSSSKTITLHILDVNDNVPVFHQ 454
Score = 61.7 bits (143), Expect = 2e-08
Identities = 66/200 (33%), Positives = 93/200 (46%), Gaps = 23/200 (11%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN P G +I + A D D G NG + Y YI S L + E+ Y ++ R G
Sbjct: 461 VAENNPPGASIAHVRASDPDLGPNGLVSY------YIVASDL--EPRELSSYVSVSARSG 512
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYN---- 1051
V R+ E F L + A D G+ L+ N+S+RV V D ND+ P+
Sbjct: 513 VVFAQRAFDHEQLRAFELTLQARDQGSPTLSANVSLRVLVDDRNDNAPLVLYPALGPEGS 572
Query: 1052 --FN-VEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSDTDLPFEISPLTGVLSVNGE 1107
F+ V + ++ KV A DAD G NA L+Y +Q S+ L F + TG +
Sbjct: 573 ALFDMVPRSAEPGYLVTKVVAVDADSGYNAWLSYHIVQASEPGL-FSLGLRTGEVRTART 631
Query: 1108 L-DRETEDKYILTVVARDNG 1126
L DRE + +L V RD G
Sbjct: 632 LGDREAARQRLL-VTVRDGG 650
Score = 47.6 bits (108), Expect = 3e-04
Identities = 49/206 (23%), Positives = 81/206 (39%), Gaps = 14/206 (6%)
Query: 957 DLDSG-LNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE----- 1010
+LD G L G + + V P++ + + K++F ++ +G+++V+ + E
Sbjct: 40 ELDRGSLVGNLAKDLGFGVGDLPTR-NLRVIAEKKFFTVSPENGNLLVSDRIDREEICGK 98
Query: 1011 -SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
S L + LN V V ++D+ND+ P F + + E T A
Sbjct: 99 KSTCVLEFEMVAEKPLNF-FHVTVLIQDINDNPPTFSQNITELEISELALTGATFALESA 157
Query: 1070 TDADFGQNANLTYFIQPSDTDLPFEISPLTG----VLSVNGELDRETEDKYILTVVARDN 1125
D D G N+ Y++ P + L G L + LDRE + + L + A D
Sbjct: 158 QDPDVGVNSLQQYYLSPDPHFSLIQKENLDGSRYPELVLKAPLDREEQPHHHLVLTAVDG 217
Query: 1126 GXXXXXXXXXXXXXXXXDVNDNSPKF 1151
G D NDN P F
Sbjct: 218 G-EPSRSCTTQIRVIVADANDNPPVF 242
Score = 39.1 bits (87), Expect = 0.12
Identities = 39/135 (28%), Positives = 57/135 (42%), Gaps = 5/135 (3%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D GVG L ++K F++ NG+L + +D + E + +T VL+ +
Sbjct: 51 AKDLGFGVGDLPTRNLRVIAEKKFFTVSPENGNLLVSDRIDRE-EICGKKSTCVLEFEMV 109
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
PL V I+ D+NDN P F + + I E G + A D D G N
Sbjct: 110 A-EKPLNFFHVTVLIQ--DINDNPPTFSQNITELEISELALTGATFALESAQDPDVGVNS 166
Query: 340 EFTYQLDDPKGAFSI 354
Y L P FS+
Sbjct: 167 LQQYYL-SPDPHFSL 180
Score = 33.9 bits (74), Expect = 4.5
Identities = 28/93 (30%), Positives = 44/93 (47%), Gaps = 9/93 (9%)
Query: 439 LMSFVNVEVTLLDANDNNPVFV-----PSNLYEFSM-KSNAKVGTVIGKVKAVDPDLGQN 492
L + V++ V + D NDN P+ + P F M +A+ G ++ KV AVD D G N
Sbjct: 542 LSANVSLRVLVDDRNDNAPLVLYPALGPEGSALFDMVPRSAEPGYLVTKVVAVDADSGYN 601
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAES 525
+ Y + + S + F + TG V A +
Sbjct: 602 AWLSYHIVQASEPGL---FSLGLRTGEVRTART 631
>AF152511-1|AAD43771.1| 820|Homo sapiens protocadherin gamma A4
short form protein protein.
Length = 820
Score = 120 bits (290), Expect = 3e-26
Identities = 124/476 (26%), Positives = 200/476 (42%), Gaps = 33/476 (6%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
N+E E + + VEV ++D NDN P F + E + N G +A DPD+G
Sbjct: 105 NLEILLEDTVKILRVEVEIIDVNDNPPSF-GTEQREIKVAENENPGARFPLPEAFDPDVG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSE 547
N + Y L ++ + V E + E H L + A D
Sbjct: 164 VNSLQGYQLNSNGYFSLDVQSGADGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVRS 223
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QND 605
+ ++ ++ T N P F Y V NV +GT + ++ D E D
Sbjct: 224 GTARILIILVD----TNDNAPV---FTQPEYHVSVRENVPVGTRLLTVKATDPDEGANGD 276
Query: 606 VSYDLLHGYEE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
V+Y ++ F + SG IT++ L + YD + A + L + V
Sbjct: 277 VTYSFRKVRDKISQLFQLNSLSGDITILGGLDYEDSGFYDIDVEA-HDGPGLRARSKVLV 335
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
V+D ND + + + V+E+S+ + +F+ + S GNG V I +
Sbjct: 336 TVLDENDNAPEVTV---TSLTSSVQESSSPGTVIALFNVHDSDSGGNGL--VTCSIPDNL 390
Query: 725 DVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
T + + T + LDRE+ Y +TV A ++G + +++ + D NDNP
Sbjct: 391 PFTLEKTYGNYYRLLTHRTLDREEVSEYNITVTAT-DQGTPPLSTETHISLQVMDINDNP 449
Query: 785 PVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFD 838
P F HA+Y +I EN+ G I + A D D G NA Y+L +
Sbjct: 450 PTFPHASYSAYIPENNPRGASILS---MTAQDPDSGDNARITYSLAEDTFQGAPLSSYVS 506
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
++ NTG++ + S D E+ +L + A D+G LSS L + + D+NDN PE
Sbjct: 507 INSNTGIL-YALCSFDYEQFRDLQLLMTASDSGDPPLSSNVSLSLFVLDQNDNVPE 561
Score = 85.4 bits (202), Expect = 1e-15
Identities = 67/252 (26%), Positives = 117/252 (46%), Gaps = 17/252 (6%)
Query: 659 VTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAA--IGQIFHTNM--SSIYGNGTG 714
+ V ++DVND G I + + GA + + F ++ +S+ G
Sbjct: 116 ILRVEVEIIDVNDNPPSF--GTEQREIKVAENENPGARFPLPEAFDPDVGVNSLQGYQLN 173
Query: 715 NVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVT 774
+ + + Q D I E + ++ LDRE+ V+ + V+ F+ G +G ++
Sbjct: 174 SNGYFSLDVQSGADGIKYPE---LVLERALDREEEAVHHL-VLTAFDGGDPVRSGTARIL 229
Query: 775 IYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYT---LFG 831
I + D NDN PVF Y + EN +GT + +KATD DEG N Y+ +
Sbjct: 230 IILVDTNDNAPVFTQPEYHVSVRENVPVGTRLL---TVKATDPDEGANGDVTYSFRKVRD 286
Query: 832 EGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKP 891
+ ++F ++ +G + +G LD E Y + + A D GL + +++++ + DENDN P
Sbjct: 287 KISQLFQLNSLSGDITILG-GLDYEDSGFYDIDVEAHDGPGLRARSKVLVTVLDENDNAP 345
Query: 892 EFNQIEENSKVR 903
E S V+
Sbjct: 346 EVTVTSLTSSVQ 357
Score = 82.6 bits (195), Expect = 1e-14
Identities = 110/461 (23%), Positives = 198/461 (42%), Gaps = 46/461 (9%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLT 506
+ L+D NDN PVF Y S++ N VGT + VKA DPD G NG V Y ++ +
Sbjct: 230 IILVDTNDNAPVFTQPE-YHVSVRENVPVGTRLLTVKATDPDEGANGDVTYSFRKVRD-K 287
Query: 507 ITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIEVTRGTK 564
I+ F++N +G +++ E G + + VEA D P R S +VT+
Sbjct: 288 ISQLFQLNSLSGDITILGGLDYEDSGFYDIDVEAHD---GPGLRARSKVLVTV------L 338
Query: 565 GNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEE 624
+ P+ V + GT + V+D+ + + + + +PF +E+
Sbjct: 339 DENDNAPEVTVTSLTSSVQESSSPGTVIALFNVHDS--DSGGNGLVTCSIPDNLPFTLEK 396
Query: 625 RSG---VITVVDDLSRYNRPMYDFEAVAL-QENANLSIVTNATVHVVDVNDERGVLLKGA 680
G + L R Y+ A Q LS T+ ++ V+D+ND +
Sbjct: 397 TYGNYYRLLTHRTLDREEVSEYNITVTATDQGTPPLSTETHISLQVMDINDNPPTFPHAS 456
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD------VTDDIAI-A 733
+S I + N GA+I +M++ + N R + +D ++ ++I +
Sbjct: 457 YSAYI--PENNPRGASI-----LSMTAQDPDSGDNARITYSLAEDTFQGAPLSSYVSINS 509
Query: 734 EDGTIFTQKPLDREK-RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
G ++ D E+ RD+ + ++ +S +++++ D+NDN P + T+
Sbjct: 510 NTGILYALCSFDYEQFRDLQLLMTASDSGDPPLSSN--VSLSLFVLDQNDNVPEILYPTF 567
Query: 793 -----EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKE-MFDVDENTGVV 846
G + + + ++ A D D G NA Y+L + +F V +TG V
Sbjct: 568 PTDGSTGVELAPRSADSGYLVTKVV-AVDRDSGQNAWLSYSLLKSSEPGLFAVGLHTGEV 626
Query: 847 KFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
+ LDR+ + +L +V +D G LS+ L + + D
Sbjct: 627 RTARALLDRD-ALKQRLVVVVQDHGQPPLSATVTLTVAVAD 666
Score = 77.4 bits (182), Expect = 4e-13
Identities = 58/163 (35%), Positives = 83/163 (50%), Gaps = 24/163 (14%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGS-------LFLEKELDLDAE-- 264
FP P A D D+GV + Y+L N FSLD +G+ L LE+ LD + E
Sbjct: 152 FPLP-EAFDPDVGVNSLQGYQL---NSNGYFSLDVQSGADGIKYPELVLERALDREEEAV 207
Query: 265 HNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFS 324
H+L F +P+++ AR+ I L+D NDN P F Y++S+ EN+P G
Sbjct: 208 HHLVLTAF-------DGGDPVRSGTARILIILVDTNDNAPVFTQPEYHVSVRENVPVGTR 260
Query: 325 VLQVMATDKDQGENGEFTYQL----DDPKGAFSIDPRSGWLTV 363
+L V ATD D+G NG+ TY D F ++ SG +T+
Sbjct: 261 LLTVKATDPDEGANGDVTYSFRKVRDKISQLFQLNSLSGDITI 303
Score = 76.2 bits (179), Expect = 9e-13
Identities = 61/217 (28%), Positives = 93/217 (42%), Gaps = 20/217 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN+P+GT ++ + A D D G NG + Y F K+ ++ + F +N G
Sbjct: 251 VRENVPVGTRLLTVKATDPDEGANGDVTYSFR--------KVRD---KISQLFQLNSLSG 299
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ + L E + +++ A DG L V V V D ND+ P T +V+E+
Sbjct: 300 DITILGGLDYEDSGFYDIDVEAHDGPGLRARSKVLVTVLDENDNAPEVTVTSLTSSVQES 359
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
V+ + D+D G N +T I +LPF + G L + LDRE
Sbjct: 360 SSPGTVIALFNVHDSDSGGNGLVTCSI---PDNLPFTLEKTYGNYYRLLTHRTLDREEVS 416
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
+Y +TV A D G D+NDN P F
Sbjct: 417 EYNITVTATDQG-TPPLSTETHISLQVMDINDNPPTF 452
Score = 74.1 bits (174), Expect = 3e-12
Identities = 74/298 (24%), Positives = 130/298 (43%), Gaps = 27/298 (9%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIFK 142
+ + + D NDN P+F YHV+V E P G + + + P V +
Sbjct: 228 ILIILVDTNDNAPVFTQPEYHVSVRENVPVGTR--LLTVKATDPDEGANGDVTYSFRKVR 285
Query: 143 DIRAFDRDKPNTPNSDVHYSIVSG---NDDGHFAL--ESSHKPVLLLR-KVLD--YDAGD 194
D + + N+ + D+ +I+ G D G + + E+ P L R KVL D D
Sbjct: 286 D-KISQLFQLNSLSGDI--TILGGLDYEDSGFYDIDVEAHDGPGLRARSKVLVTVLDEND 342
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGATLRYELISGNDRKLFSLDSVN 250
++ + + + +E P + A+ D D G + + D F+L+
Sbjct: 343 NAPEVTVTSLTSSV-QESSSPGTVIALFNVHDSDSGGNGLVTCSI---PDNLPFTLEKTY 398
Query: 251 GSLF-LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
G+ + L LD E + + + + V A+ P + + + ++++D+NDN P F
Sbjct: 399 GNYYRLLTHRTLDRE---EVSEYNITVTATDQGTPPLSTETHISLQVMDINDNPPTFPHA 455
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQT 367
Y+ I EN P G S+L + A D D G+N TY L + F P S ++++ + T
Sbjct: 456 SYSAYIPENNPRGASILSMTAQDPDSGDNARITYSL--AEDTFQGAPLSSYVSINSNT 511
Score = 63.7 bits (148), Expect = 5e-09
Identities = 61/199 (30%), Positives = 91/199 (45%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P G +I+ + A D DSG N +I Y + + + Y IN G
Sbjct: 461 IPENNPRGASILSMTAQDPDSGDNARITYSLAEDTF--------QGAPLSSYVSINSNTG 512
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFP-VFKKTWYNFNV 1054
+ S E + +L ++A D G+ L+ N+S+ +FV D ND+ P + T+
Sbjct: 513 ILYALCSFDYEQFRDLQLLMTASDSGDPPLSSNVSLSLFVLDQNDNVPEILYPTFPTDGS 572
Query: 1055 EEAQYTRR------VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG-VLSVNGE 1107
+ R ++ KV A D D GQNA L+Y + S F + TG V +
Sbjct: 573 TGVELAPRSADSGYLVTKVVAVDRDSGQNAWLSYSLLKSSEPGLFAVGLHTGEVRTARAL 632
Query: 1108 LDRETEDKYILTVVARDNG 1126
LDR+ K L VV +D+G
Sbjct: 633 LDRDAL-KQRLVVVVQDHG 650
Score = 62.1 bits (144), Expect = 1e-08
Identities = 60/218 (27%), Positives = 95/218 (43%), Gaps = 20/218 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLS-ADALEVKRYFVINERH 998
+ EN G A D D G+N Y+ NS Y S AD + ++
Sbjct: 142 VAENENPGARFPLPEAFDPDVGVNSLQGYQLNSNGYFSLDVQSGADGI----------KY 191
Query: 999 GHVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFV--KDVNDHFPVFKKTWYNFNV 1054
+++ R+L E E L ++A DGG+ + + R+ + D ND+ PVF + Y+ +V
Sbjct: 192 PELVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNAPVFTQPEYHVSV 251
Query: 1055 EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP--FEISPLTGVLSVNGELDRET 1112
E L V ATD D G N ++TY + + F+++ L+G +++ G LD E
Sbjct: 252 RENVPVGTRLLTVKATDPDEGANGDVTYSFRKVRDKISQLFQLNSLSGDITILGGLDYED 311
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
Y + V A D D NDN+P+
Sbjct: 312 SGFYDIDVEAHDG---PGLRARSKVLVTVLDENDNAPE 346
Score = 52.0 bits (119), Expect = 2e-05
Identities = 46/179 (25%), Positives = 78/179 (43%), Gaps = 11/179 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR--KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A D D G + Y D+ +LF L+S++G + + LD + + + +
Sbjct: 264 VKATDPDEGANGDVTYSFRKVRDKISQLFQLNSLSGDITILGGLDYE-----DSGFYDID 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
V+A + P A+++V + +LD NDN PE V S+ E+ G + D D
Sbjct: 319 VEAH--DGPGLRARSKVLVTVLDENDNAPEVTVTSLTSSVQESSSPGTVIALFNVHDSDS 376
Query: 336 GENGEFTYQLDDPKGAFSIDPRSG-WLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
G NG T + D F+++ G + + LDRE S + V A + + T
Sbjct: 377 GGNGLVTCSIPD-NLPFTLEKTYGNYYRLLTHRTLDREEVSEYNITVTATDQGTPPLST 434
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/154 (28%), Positives = 73/154 (47%), Gaps = 12/154 (7%)
Query: 744 LDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIG 803
LD E Y + V A G+ + + +V + + DENDN P + + E+S G
Sbjct: 307 LDYEDSGFYDIDVEAHDGPGLRARS---KVLVTVLDENDNAPEVTVTSLTSSVQESSSPG 363
Query: 804 TEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTG-VVKFIGD-SLDREKKIMY 861
T I + N+ D+D G N L ++ F +++ G + + +LDRE+ Y
Sbjct: 364 TVIALFNV---HDSDSGGNGLVTCSI--PDNLPFTLEKTYGNYYRLLTHRTLDREEVSEY 418
Query: 862 KLSLVARDTGG--LSSEAELIIMIGDENDNKPEF 893
+++ A D G LS+E + + + D NDN P F
Sbjct: 419 NITVTATDQGTPPLSTETHISLQVMDINDNPPTF 452
Score = 50.4 bits (115), Expect = 5e-05
Identities = 44/143 (30%), Positives = 69/143 (48%), Gaps = 9/143 (6%)
Query: 221 IDQDLGVG----ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
I +DLG+ A ++S +LF+L+ +G+L +D + + N V +
Sbjct: 48 IAKDLGLAPRELAERGVRIVSRGRTQLFALNPRSGTLVTAGRIDREELCDRSPNC-VTNL 106
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+ L + +K RVE+E++D+NDN P F + I + EN G A D D G
Sbjct: 107 EIL-LEDTVKIL--RVEVEIIDVNDNPPSFGTEQREIKVAENENPGARFPLPEAFDPDVG 163
Query: 337 ENGEFTYQLDDPKGAFSIDPRSG 359
N YQL+ G FS+D +SG
Sbjct: 164 VNSLQGYQLNS-NGYFSLDVQSG 185
Score = 49.2 bits (112), Expect = 1e-04
Identities = 53/192 (27%), Positives = 84/192 (43%), Gaps = 21/192 (10%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
++ V +N A +V + E+ GT I N D DSG NG +
Sbjct: 334 LVTVLDENDNAPEVTVTSLTSSVQESSSPGTVIALFNVHDSDSGGNGLVTCSI------- 386
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN--LNDNISVRV 1033
P L LE K Y + ++ R+L E SE+ + ++A D G L+ + +
Sbjct: 387 PDNLPF-TLE-KTY----GNYYRLLTHRTLDREEVSEYNITVTATDQGTPPLSTETHISL 440
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPF 1093
V D+ND+ P F Y+ + E + + A D D G NA +TY + DT F
Sbjct: 441 QVMDINDNPPTFPHASYSAYIPENNPRGASILSMTAQDPDSGDNARITYSL-AEDT---F 496
Query: 1094 EISPLTGVLSVN 1105
+ +PL+ +S+N
Sbjct: 497 QGAPLSSYVSIN 508
Score = 45.2 bits (102), Expect = 0.002
Identities = 48/188 (25%), Positives = 81/188 (43%), Gaps = 20/188 (10%)
Query: 220 AIDQDLGVGATLRYELISGNDR-----KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
A D D G A + Y L + S++S G L+ D + +LQ L
Sbjct: 476 AQDPDSGDNARITYSLAEDTFQGAPLSSYVSINSNTGILYALCSFDYEQFRDLQ-----L 530
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY---NISIVENLP----NGFSVLQ 327
+ AS +P ++ + + +LD NDN+PE + + VE P +G+ V +
Sbjct: 531 LMTASDSGDPPLSSNVSLSLFVLDQNDNVPEILYPTFPTDGSTGVELAPRSADSGYLVTK 590
Query: 328 VMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
V+A D+D G+N +Y L G F++ +G + + +LDR+A + V
Sbjct: 591 VVAVDRDSGQNAWLSYSLLKSSEPGLFAVGLHTGEVRTA-RALLDRDALKQRLVVVVQDH 649
Query: 386 TNPSVVGT 393
P + T
Sbjct: 650 GQPPLSAT 657
Score = 43.2 bits (97), Expect = 0.007
Identities = 94/396 (23%), Positives = 149/396 (37%), Gaps = 58/396 (14%)
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
+ V V + DVND+ P F V E + +A D D G N+ Y + S+
Sbjct: 117 LRVEVEIIDVNDNPPSFGTEQREIKVAENENPGARFPLPEAFDPDVGVNSLQGYQLN-SN 175
Query: 1089 TDLPFEI-SPLTGV----LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXD 1143
++ S G+ L + LDRE E + L + A D G D
Sbjct: 176 GYFSLDVQSGADGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILV-D 234
Query: 1144 VNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFAND 1203
NDN+P V P Y ++ EN P+GT + V A D
Sbjct: 235 TNDNAP--------------------------VFTQPEYHVSVRENVPVGTRLLTVKATD 268
Query: 1204 TDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPD------EVEMSDKPVF 1257
D NG+ + + K Q L SLS I ++ D D +VE D P
Sbjct: 269 PDEGANGDVTYSFRKVRDKISQLFQLNSLSGD-ITILGGLDYEDSGFYDIDVEAHDGPGL 327
Query: 1258 ISRYYEL--EIEENVNAPVELVSLNLTEHYENFKMRYYIL---NENDTDIRRTFVID--- 1309
+R L ++EN NAP E+ +LT + ++ N +D+D ++
Sbjct: 328 RARSKVLVTVLDENDNAP-EVTVTSLTSSVQESSSPGTVIALFNVHDSDSGGNGLVTCSI 386
Query: 1310 PRNGTLYLVRSPDREVK-DTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVV 1368
P N L ++ + T+ + R E +Y+ I A D + + +
Sbjct: 387 PDNLPFTLEKTYGNYYRLLTHRTLDREEVSEYN------ITVTATDQGTPPLSTETHISL 440
Query: 1369 RIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQL 1404
++ D+NDN P F + + IP P G ++ +
Sbjct: 441 QVMDINDNPPTFPHAS--YSAYIPENNPRGASILSM 474
Score = 39.5 bits (88), Expect = 0.091
Identities = 38/118 (32%), Positives = 58/118 (49%), Gaps = 15/118 (12%)
Query: 436 DEQLMSFVNVEVTLLDANDNNP-VFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPD 488
D L S V++ + +LD NDN P + P S E + +S A G ++ KV AVD D
Sbjct: 539 DPPLSSNVSLSLFVLDQNDNVPEILYPTFPTDGSTGVELAPRS-ADSGYLVTKVVAVDRD 597
Query: 489 LGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI----LEGRHALFVEASDQP 542
GQN + Y L ++S + F + +TG V A + + L+ R + V+ QP
Sbjct: 598 SGQNAWLSYSLLKSSEPGL---FAVGLHTGEVRTARALLDRDALKQRLVVVVQDHGQP 652
>AF152324-1|AAD43718.1| 931|Homo sapiens protocadherin gamma A4
protein.
Length = 931
Score = 120 bits (290), Expect = 3e-26
Identities = 124/476 (26%), Positives = 200/476 (42%), Gaps = 33/476 (6%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
N+E E + + VEV ++D NDN P F + E + N G +A DPD+G
Sbjct: 105 NLEILLEDTVKILRVEVEIIDVNDNPPSF-GTEQREIKVAENENPGARFPLPEAFDPDVG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSE 547
N + Y L ++ + V E + E H L + A D
Sbjct: 164 VNSLQGYQLNSNGYFSLDVQSGADGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVRS 223
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QND 605
+ ++ ++ T N P F Y V NV +GT + ++ D E D
Sbjct: 224 GTARILIILVD----TNDNAPV---FTQPEYHVSVRENVPVGTRLLTVKATDPDEGANGD 276
Query: 606 VSYDLLHGYEE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
V+Y ++ F + SG IT++ L + YD + A + L + V
Sbjct: 277 VTYSFRKVRDKISQLFQLNSLSGDITILGGLDYEDSGFYDIDVEA-HDGPGLRARSKVLV 335
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
V+D ND + + + V+E+S+ + +F+ + S GNG V I +
Sbjct: 336 TVLDENDNAPEVTV---TSLTSSVQESSSPGTVIALFNVHDSDSGGNGL--VTCSIPDNL 390
Query: 725 DVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
T + + T + LDRE+ Y +TV A ++G + +++ + D NDNP
Sbjct: 391 PFTLEKTYGNYYRLLTHRTLDREEVSEYNITVTAT-DQGTPPLSTETHISLQVMDINDNP 449
Query: 785 PVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFD 838
P F HA+Y +I EN+ G I + A D D G NA Y+L +
Sbjct: 450 PTFPHASYSAYIPENNPRGASILS---MTAQDPDSGDNARITYSLAEDTFQGAPLSSYVS 506
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
++ NTG++ + S D E+ +L + A D+G LSS L + + D+NDN PE
Sbjct: 507 INSNTGIL-YALCSFDYEQFRDLQLLMTASDSGDPPLSSNVSLSLFVLDQNDNVPE 561
Score = 85.4 bits (202), Expect = 1e-15
Identities = 67/252 (26%), Positives = 117/252 (46%), Gaps = 17/252 (6%)
Query: 659 VTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAA--IGQIFHTNM--SSIYGNGTG 714
+ V ++DVND G I + + GA + + F ++ +S+ G
Sbjct: 116 ILRVEVEIIDVNDNPPSF--GTEQREIKVAENENPGARFPLPEAFDPDVGVNSLQGYQLN 173
Query: 715 NVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVT 774
+ + + Q D I E + ++ LDRE+ V+ + V+ F+ G +G ++
Sbjct: 174 SNGYFSLDVQSGADGIKYPE---LVLERALDREEEAVHHL-VLTAFDGGDPVRSGTARIL 229
Query: 775 IYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYT---LFG 831
I + D NDN PVF Y + EN +GT + +KATD DEG N Y+ +
Sbjct: 230 IILVDTNDNAPVFTQPEYHVSVRENVPVGTRLL---TVKATDPDEGANGDVTYSFRKVRD 286
Query: 832 EGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKP 891
+ ++F ++ +G + +G LD E Y + + A D GL + +++++ + DENDN P
Sbjct: 287 KISQLFQLNSLSGDITILG-GLDYEDSGFYDIDVEAHDGPGLRARSKVLVTVLDENDNAP 345
Query: 892 EFNQIEENSKVR 903
E S V+
Sbjct: 346 EVTVTSLTSSVQ 357
Score = 82.6 bits (195), Expect = 1e-14
Identities = 110/461 (23%), Positives = 198/461 (42%), Gaps = 46/461 (9%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLT 506
+ L+D NDN PVF Y S++ N VGT + VKA DPD G NG V Y ++ +
Sbjct: 230 IILVDTNDNAPVFTQPE-YHVSVRENVPVGTRLLTVKATDPDEGANGDVTYSFRKVRD-K 287
Query: 507 ITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIEVTRGTK 564
I+ F++N +G +++ E G + + VEA D P R S +VT+
Sbjct: 288 ISQLFQLNSLSGDITILGGLDYEDSGFYDIDVEAHD---GPGLRARSKVLVTV------L 338
Query: 565 GNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEE 624
+ P+ V + GT + V+D+ + + + + +PF +E+
Sbjct: 339 DENDNAPEVTVTSLTSSVQESSSPGTVIALFNVHDS--DSGGNGLVTCSIPDNLPFTLEK 396
Query: 625 RSG---VITVVDDLSRYNRPMYDFEAVAL-QENANLSIVTNATVHVVDVNDERGVLLKGA 680
G + L R Y+ A Q LS T+ ++ V+D+ND +
Sbjct: 397 TYGNYYRLLTHRTLDREEVSEYNITVTATDQGTPPLSTETHISLQVMDINDNPPTFPHAS 456
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD------VTDDIAI-A 733
+S I + N GA+I +M++ + N R + +D ++ ++I +
Sbjct: 457 YSAYI--PENNPRGASI-----LSMTAQDPDSGDNARITYSLAEDTFQGAPLSSYVSINS 509
Query: 734 EDGTIFTQKPLDREK-RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
G ++ D E+ RD+ + ++ +S +++++ D+NDN P + T+
Sbjct: 510 NTGILYALCSFDYEQFRDLQLLMTASDSGDPPLSSN--VSLSLFVLDQNDNVPEILYPTF 567
Query: 793 -----EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKE-MFDVDENTGVV 846
G + + + ++ A D D G NA Y+L + +F V +TG V
Sbjct: 568 PTDGSTGVELAPRSADSGYLVTKVV-AVDRDSGQNAWLSYSLLKSSEPGLFAVGLHTGEV 626
Query: 847 KFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
+ LDR+ + +L +V +D G LS+ L + + D
Sbjct: 627 RTARALLDRD-ALKQRLVVVVQDHGQPPLSATVTLTVAVAD 666
Score = 77.4 bits (182), Expect = 4e-13
Identities = 58/163 (35%), Positives = 83/163 (50%), Gaps = 24/163 (14%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGS-------LFLEKELDLDAE-- 264
FP P A D D+GV + Y+L N FSLD +G+ L LE+ LD + E
Sbjct: 152 FPLP-EAFDPDVGVNSLQGYQL---NSNGYFSLDVQSGADGIKYPELVLERALDREEEAV 207
Query: 265 HNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFS 324
H+L F +P+++ AR+ I L+D NDN P F Y++S+ EN+P G
Sbjct: 208 HHLVLTAF-------DGGDPVRSGTARILIILVDTNDNAPVFTQPEYHVSVRENVPVGTR 260
Query: 325 VLQVMATDKDQGENGEFTYQL----DDPKGAFSIDPRSGWLTV 363
+L V ATD D+G NG+ TY D F ++ SG +T+
Sbjct: 261 LLTVKATDPDEGANGDVTYSFRKVRDKISQLFQLNSLSGDITI 303
Score = 76.2 bits (179), Expect = 9e-13
Identities = 61/217 (28%), Positives = 93/217 (42%), Gaps = 20/217 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN+P+GT ++ + A D D G NG + Y F K+ ++ + F +N G
Sbjct: 251 VRENVPVGTRLLTVKATDPDEGANGDVTYSFR--------KVRD---KISQLFQLNSLSG 299
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ + L E + +++ A DG L V V V D ND+ P T +V+E+
Sbjct: 300 DITILGGLDYEDSGFYDIDVEAHDGPGLRARSKVLVTVLDENDNAPEVTVTSLTSSVQES 359
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
V+ + D+D G N +T I +LPF + G L + LDRE
Sbjct: 360 SSPGTVIALFNVHDSDSGGNGLVTCSI---PDNLPFTLEKTYGNYYRLLTHRTLDREEVS 416
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
+Y +TV A D G D+NDN P F
Sbjct: 417 EYNITVTATDQG-TPPLSTETHISLQVMDINDNPPTF 452
Score = 74.1 bits (174), Expect = 3e-12
Identities = 74/298 (24%), Positives = 130/298 (43%), Gaps = 27/298 (9%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIFK 142
+ + + D NDN P+F YHV+V E P G + + + P V +
Sbjct: 228 ILIILVDTNDNAPVFTQPEYHVSVRENVPVGTR--LLTVKATDPDEGANGDVTYSFRKVR 285
Query: 143 DIRAFDRDKPNTPNSDVHYSIVSG---NDDGHFAL--ESSHKPVLLLR-KVLD--YDAGD 194
D + + N+ + D+ +I+ G D G + + E+ P L R KVL D D
Sbjct: 286 D-KISQLFQLNSLSGDI--TILGGLDYEDSGFYDIDVEAHDGPGLRARSKVLVTVLDEND 342
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGATLRYELISGNDRKLFSLDSVN 250
++ + + + +E P + A+ D D G + + D F+L+
Sbjct: 343 NAPEVTVTSLTSSV-QESSSPGTVIALFNVHDSDSGGNGLVTCSI---PDNLPFTLEKTY 398
Query: 251 GSLF-LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
G+ + L LD E + + + + V A+ P + + + ++++D+NDN P F
Sbjct: 399 GNYYRLLTHRTLDRE---EVSEYNITVTATDQGTPPLSTETHISLQVMDINDNPPTFPHA 455
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQT 367
Y+ I EN P G S+L + A D D G+N TY L + F P S ++++ + T
Sbjct: 456 SYSAYIPENNPRGASILSMTAQDPDSGDNARITYSL--AEDTFQGAPLSSYVSINSNT 511
Score = 63.7 bits (148), Expect = 5e-09
Identities = 61/199 (30%), Positives = 91/199 (45%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P G +I+ + A D DSG N +I Y + + + Y IN G
Sbjct: 461 IPENNPRGASILSMTAQDPDSGDNARITYSLAEDTF--------QGAPLSSYVSINSNTG 512
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFP-VFKKTWYNFNV 1054
+ S E + +L ++A D G+ L+ N+S+ +FV D ND+ P + T+
Sbjct: 513 ILYALCSFDYEQFRDLQLLMTASDSGDPPLSSNVSLSLFVLDQNDNVPEILYPTFPTDGS 572
Query: 1055 EEAQYTRR------VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG-VLSVNGE 1107
+ R ++ KV A D D GQNA L+Y + S F + TG V +
Sbjct: 573 TGVELAPRSADSGYLVTKVVAVDRDSGQNAWLSYSLLKSSEPGLFAVGLHTGEVRTARAL 632
Query: 1108 LDRETEDKYILTVVARDNG 1126
LDR+ K L VV +D+G
Sbjct: 633 LDRDAL-KQRLVVVVQDHG 650
Score = 62.1 bits (144), Expect = 1e-08
Identities = 60/218 (27%), Positives = 95/218 (43%), Gaps = 20/218 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLS-ADALEVKRYFVINERH 998
+ EN G A D D G+N Y+ NS Y S AD + ++
Sbjct: 142 VAENENPGARFPLPEAFDPDVGVNSLQGYQLNSNGYFSLDVQSGADGI----------KY 191
Query: 999 GHVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFV--KDVNDHFPVFKKTWYNFNV 1054
+++ R+L E E L ++A DGG+ + + R+ + D ND+ PVF + Y+ +V
Sbjct: 192 PELVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNAPVFTQPEYHVSV 251
Query: 1055 EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP--FEISPLTGVLSVNGELDRET 1112
E L V ATD D G N ++TY + + F+++ L+G +++ G LD E
Sbjct: 252 RENVPVGTRLLTVKATDPDEGANGDVTYSFRKVRDKISQLFQLNSLSGDITILGGLDYED 311
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
Y + V A D D NDN+P+
Sbjct: 312 SGFYDIDVEAHDG---PGLRARSKVLVTVLDENDNAPE 346
Score = 52.0 bits (119), Expect = 2e-05
Identities = 46/179 (25%), Positives = 78/179 (43%), Gaps = 11/179 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR--KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A D D G + Y D+ +LF L+S++G + + LD + + + +
Sbjct: 264 VKATDPDEGANGDVTYSFRKVRDKISQLFQLNSLSGDITILGGLDYE-----DSGFYDID 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
V+A + P A+++V + +LD NDN PE V S+ E+ G + D D
Sbjct: 319 VEAH--DGPGLRARSKVLVTVLDENDNAPEVTVTSLTSSVQESSSPGTVIALFNVHDSDS 376
Query: 336 GENGEFTYQLDDPKGAFSIDPRSG-WLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
G NG T + D F+++ G + + LDRE S + V A + + T
Sbjct: 377 GGNGLVTCSIPD-NLPFTLEKTYGNYYRLLTHRTLDREEVSEYNITVTATDQGTPPLST 434
Score = 51.2 bits (117), Expect = 3e-05
Identities = 44/154 (28%), Positives = 73/154 (47%), Gaps = 12/154 (7%)
Query: 744 LDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIG 803
LD E Y + V A G+ + + +V + + DENDN P + + E+S G
Sbjct: 307 LDYEDSGFYDIDVEAHDGPGLRARS---KVLVTVLDENDNAPEVTVTSLTSSVQESSSPG 363
Query: 804 TEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTG-VVKFIGD-SLDREKKIMY 861
T I + N+ D+D G N L ++ F +++ G + + +LDRE+ Y
Sbjct: 364 TVIALFNV---HDSDSGGNGLVTCSI--PDNLPFTLEKTYGNYYRLLTHRTLDREEVSEY 418
Query: 862 KLSLVARDTGG--LSSEAELIIMIGDENDNKPEF 893
+++ A D G LS+E + + + D NDN P F
Sbjct: 419 NITVTATDQGTPPLSTETHISLQVMDINDNPPTF 452
Score = 50.4 bits (115), Expect = 5e-05
Identities = 44/143 (30%), Positives = 69/143 (48%), Gaps = 9/143 (6%)
Query: 221 IDQDLGVG----ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
I +DLG+ A ++S +LF+L+ +G+L +D + + N V +
Sbjct: 48 IAKDLGLAPRELAERGVRIVSRGRTQLFALNPRSGTLVTAGRIDREELCDRSPNC-VTNL 106
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+ L + +K RVE+E++D+NDN P F + I + EN G A D D G
Sbjct: 107 EIL-LEDTVKIL--RVEVEIIDVNDNPPSFGTEQREIKVAENENPGARFPLPEAFDPDVG 163
Query: 337 ENGEFTYQLDDPKGAFSIDPRSG 359
N YQL+ G FS+D +SG
Sbjct: 164 VNSLQGYQLNS-NGYFSLDVQSG 185
Score = 49.2 bits (112), Expect = 1e-04
Identities = 53/192 (27%), Positives = 84/192 (43%), Gaps = 21/192 (10%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
++ V +N A +V + E+ GT I N D DSG NG +
Sbjct: 334 LVTVLDENDNAPEVTVTSLTSSVQESSSPGTVIALFNVHDSDSGGNGLVTCSI------- 386
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN--LNDNISVRV 1033
P L LE K Y + ++ R+L E SE+ + ++A D G L+ + +
Sbjct: 387 PDNLPF-TLE-KTY----GNYYRLLTHRTLDREEVSEYNITVTATDQGTPPLSTETHISL 440
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPF 1093
V D+ND+ P F Y+ + E + + A D D G NA +TY + DT F
Sbjct: 441 QVMDINDNPPTFPHASYSAYIPENNPRGASILSMTAQDPDSGDNARITYSL-AEDT---F 496
Query: 1094 EISPLTGVLSVN 1105
+ +PL+ +S+N
Sbjct: 497 QGAPLSSYVSIN 508
Score = 45.2 bits (102), Expect = 0.002
Identities = 48/188 (25%), Positives = 81/188 (43%), Gaps = 20/188 (10%)
Query: 220 AIDQDLGVGATLRYELISGNDR-----KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
A D D G A + Y L + S++S G L+ D + +LQ L
Sbjct: 476 AQDPDSGDNARITYSLAEDTFQGAPLSSYVSINSNTGILYALCSFDYEQFRDLQ-----L 530
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFY---NISIVENLP----NGFSVLQ 327
+ AS +P ++ + + +LD NDN+PE + + VE P +G+ V +
Sbjct: 531 LMTASDSGDPPLSSNVSLSLFVLDQNDNVPEILYPTFPTDGSTGVELAPRSADSGYLVTK 590
Query: 328 VMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
V+A D+D G+N +Y L G F++ +G + + +LDR+A + V
Sbjct: 591 VVAVDRDSGQNAWLSYSLLKSSEPGLFAVGLHTGEVRTA-RALLDRDALKQRLVVVVQDH 649
Query: 386 TNPSVVGT 393
P + T
Sbjct: 650 GQPPLSAT 657
Score = 43.2 bits (97), Expect = 0.007
Identities = 94/396 (23%), Positives = 149/396 (37%), Gaps = 58/396 (14%)
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
+ V V + DVND+ P F V E + +A D D G N+ Y + S+
Sbjct: 117 LRVEVEIIDVNDNPPSFGTEQREIKVAENENPGARFPLPEAFDPDVGVNSLQGYQLN-SN 175
Query: 1089 TDLPFEI-SPLTGV----LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXD 1143
++ S G+ L + LDRE E + L + A D G D
Sbjct: 176 GYFSLDVQSGADGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILV-D 234
Query: 1144 VNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFAND 1203
NDN+P V P Y ++ EN P+GT + V A D
Sbjct: 235 TNDNAP--------------------------VFTQPEYHVSVRENVPVGTRLLTVKATD 268
Query: 1204 TDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPD------EVEMSDKPVF 1257
D NG+ + + K Q L SLS I ++ D D +VE D P
Sbjct: 269 PDEGANGDVTYSFRKVRDKISQLFQLNSLSGD-ITILGGLDYEDSGFYDIDVEAHDGPGL 327
Query: 1258 ISRYYEL--EIEENVNAPVELVSLNLTEHYENFKMRYYIL---NENDTDIRRTFVID--- 1309
+R L ++EN NAP E+ +LT + ++ N +D+D ++
Sbjct: 328 RARSKVLVTVLDENDNAP-EVTVTSLTSSVQESSSPGTVIALFNVHDSDSGGNGLVTCSI 386
Query: 1310 PRNGTLYLVRSPDREVK-DTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVV 1368
P N L ++ + T+ + R E +Y+ I A D + + +
Sbjct: 387 PDNLPFTLEKTYGNYYRLLTHRTLDREEVSEYN------ITVTATDQGTPPLSTETHISL 440
Query: 1369 RIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQL 1404
++ D+NDN P F + + IP P G ++ +
Sbjct: 441 QVMDINDNPPTFPHAS--YSAYIPENNPRGASILSM 474
Score = 39.5 bits (88), Expect = 0.091
Identities = 38/118 (32%), Positives = 58/118 (49%), Gaps = 15/118 (12%)
Query: 436 DEQLMSFVNVEVTLLDANDNNP-VFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPD 488
D L S V++ + +LD NDN P + P S E + +S A G ++ KV AVD D
Sbjct: 539 DPPLSSNVSLSLFVLDQNDNVPEILYPTFPTDGSTGVELAPRS-ADSGYLVTKVVAVDRD 597
Query: 489 LGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI----LEGRHALFVEASDQP 542
GQN + Y L ++S + F + +TG V A + + L+ R + V+ QP
Sbjct: 598 SGQNAWLSYSLLKSSEPGL---FAVGLHTGEVRTARALLDRDALKQRLVVVVQDHGQP 652
>AY714129-1|AAU94938.1| 4186|Homo sapiens anchor protein protein.
Length = 4186
Score = 118 bits (285), Expect = 1e-25
Identities = 134/487 (27%), Positives = 217/487 (44%), Gaps = 39/487 (8%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L + +V VT+LD NDN P F Y + +A VGT + V AVD D N + Y
Sbjct: 806 LSASASVTVTVLDVNDNRPEFTMKE-YHLRLNEDAAVGTSVVSVTAVDRDA--NSAISYQ 862
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERR-YSLAVVTI 557
+ T T + F I+ G V + L+ + + + S+R + V I
Sbjct: 863 I--TGGNT-RNRFAISTQGGVGLVTLALPLDYKQERYFKLV---LTASDRALHDHCYVHI 916
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGY--E 615
+T P F A Y V + +G+++ I +D +DV + Y E
Sbjct: 917 NITDANTHR----PVFQSAHYSVSVNEDRPMGSTIVVISASD----DDVGENARITYLLE 968
Query: 616 EGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA--NLSIVTNATVHVVDVNDE 672
+ +P F ++ SG IT+ L ++ Y A+ ++N + T V V DVND
Sbjct: 969 DNLPQFRIDADSGAITLQAPLDYEDQVTYTL-AITARDNGIPQKADTTYVEVMVNDVNDN 1027
Query: 673 RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI 732
+ ++ ++ ++ ++ QI T+ + + G V++ N +D D I
Sbjct: 1028 APQFVASHYTGLVS--EDAPPFTSVLQISATDRDA---HANGRVQYTFQNGEDGDGDFTI 1082
Query: 733 AE-DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
G + T + LDRE VY +T A ++GV + + ++D NDN PVF
Sbjct: 1083 EPTSGIVRTVRRLDREAVSVYELTAYA-VDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEE 1141
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTGVVKFIG 850
+E + ENS +G+ + I A D DEG NA MY + G E+F +D +G + +
Sbjct: 1142 FEVRVKENSIVGSVVAQ---ITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALI 1198
Query: 851 DSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFN--QIEENSKVRIHRET 908
D LD E + Y + +V + L S A + + + D+NDN P N QI N+ V +T
Sbjct: 1199 D-LDYEARQEYVI-VVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDT 1256
Query: 909 KLNGTAG 915
+G G
Sbjct: 1257 FPSGIIG 1263
Score = 109 bits (261), Expect = 1e-22
Identities = 118/458 (25%), Positives = 188/458 (41%), Gaps = 27/458 (5%)
Query: 452 ANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPF 511
A + +P F P Y+ + N GT + +V A DPD G+ G ++Y L N F
Sbjct: 388 AANRHPQF-PQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELF 446
Query: 512 KINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPD 569
I+P +G + A + E RH L V A D +P ++ VT+
Sbjct: 447 SIDPQSGLIRTAAALDRESMERHYLRVTAQDH-GSPRLSATTMVAVTV------ADRNDH 499
Query: 570 IPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLL----HGYEEGVPFAVE 623
P F A Y + NV G + Q+R DA ++ Y + F ++
Sbjct: 500 SPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEID 559
Query: 624 ERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHV-VDVNDERGVLLKGAHS 682
RSG+I+ + R + Y+ V + +ATV V + V DE + +
Sbjct: 560 PRSGLISTSGRVDREHMESYEL-VVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEK 618
Query: 683 PIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQK 742
+ V+E+ + + + + G V + I + + G I
Sbjct: 619 RYVAQVREDVRPHTV--VLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVA 676
Query: 743 PLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKI 802
PLD E Y + + A+ +I + D ND+ P+F ++ ++EN+ +
Sbjct: 677 PLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPL 736
Query: 803 GTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM-FDVDENTGVVKFIGDSLDREKKIMY 861
G + I+A DAD G NA Y+L G + F ++ TG V G LDRE Y
Sbjct: 737 GHSVIH---IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSG-PLDRESVEHY 792
Query: 862 KLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
+ ARD G LS+ A + + + D NDN+PEF E
Sbjct: 793 FFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKE 830
Score = 103 bits (246), Expect = 7e-21
Identities = 119/481 (24%), Positives = 198/481 (41%), Gaps = 33/481 (6%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L + V VT+ D ND++PVF + Y +++ N + G I +++A D D N + Y
Sbjct: 482 RLSATTMVAVTVADRNDHSPVFEQAQ-YRETLRENVEEGYPILQLRATDGDAPPNANLRY 540
Query: 498 DL--QRTSNLTITSPFKINPNTGTVSVAESPILEGRHA--LFVEASDQPANPSERRYSLA 553
+ + F+I+P +G +S + E + L VEASDQ P R A
Sbjct: 541 RFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRS---A 597
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND--VSYDLL 611
V + +T + P F Y V +V T V ++ D + + V Y+++
Sbjct: 598 TVRVHIT--VLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNII 655
Query: 612 HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTN---ATVHVVD 668
G G FA++ +G I VV L Y + Q+ + N A++ VVD
Sbjct: 656 SGNSRG-HFAIDSLTGEIQVVAPLDFEAEREYALR-IRAQDAGRPPLSNNTGLASIQVVD 713
Query: 669 VNDERGVLLKGAHSPIIFHVKENSAGAAIGQ-IFHTNMSSIYGNGTGNVRFLIANQQDVT 727
+ND + + +P V EN A +G + H + + + T
Sbjct: 714 INDHIPIFVS---TPFQVSVLEN---APLGHSVIHIQAVDADHGENARLEYSLTGVAPDT 767
Query: 728 DDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVF 787
+ + G + PLDRE + Y V A + G + VT+ + D NDN P F
Sbjct: 768 PFVINSATGWVSVSGPLDRESVEHYFFGVEAR-DHGSPPLSASASVTVTVLDVNDNRPEF 826
Query: 788 EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTGV- 845
Y + E++ +GT +++ T D N+ Y + G + F + GV
Sbjct: 827 TMKEYHLRLNEDAAVGT-----SVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVG 881
Query: 846 VKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIH 905
+ + LD +++ +KL L A D L + I I D N ++P F + V
Sbjct: 882 LVTLALPLDYKQERYFKLVLTASDR-ALHDHCYVHINITDANTHRPVFQSAHYSVSVNED 940
Query: 906 R 906
R
Sbjct: 941 R 941
Score = 99.5 bits (237), Expect = 8e-20
Identities = 123/467 (26%), Positives = 201/467 (43%), Gaps = 66/467 (14%)
Query: 939 LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERH 998
L+PEN GT ++++ A D D+G G++ VY + +++ +LE+ F I+ +
Sbjct: 403 LVPENEAAGTAVLRVVAQDPDAGEAGRL-------VYSLAALMNSRSLEL---FSIDPQS 452
Query: 999 GHVIVARSLPPESEFR--LNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNV 1054
G + A +L ES R L ++A D G+ L+ V V V D NDH PVF++ Y +
Sbjct: 453 GLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETL 512
Query: 1055 EEAQYTRRVLGKVDATDADFGQNANLTY-FIQP----SDTDLPFEISPLTGVLSVNGELD 1109
E + ++ ATD D NANL Y F+ P + FEI P +G++S +G +D
Sbjct: 513 RENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVD 572
Query: 1110 RETEDKYILTVVARDNGXX-XXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADEL 1168
RE + Y L V A D G D NDN+P+F + + + +++
Sbjct: 573 REHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVR----EDV 628
Query: 1169 SNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLP--------- 1219
H V+ + + N + + + I + G I P
Sbjct: 629 RPHTV--VLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREY 686
Query: 1220 -QRKNQQNLGLPSLS-STAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELV 1277
R Q+ G P LS +T + + V D+ D + P+F+S +++ + EN ++
Sbjct: 687 ALRIRAQDAGRPPLSNNTGLASIQVVDINDHI-----PIFVSTPFQVSVLENAPLGHSVI 741
Query: 1278 SLNL--TEHYENFKMRYYILN-ENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVR 1334
+ +H EN ++ Y + DT FVI+ G + + DRE + Y V
Sbjct: 742 HIQAVDADHGENARLEYSLTGVAPDT----PFVINSATGWVSVSGPLDRESVEHYFFGVE 797
Query: 1335 AERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A H P++ V V + DVNDN P+FT
Sbjct: 798 AR--------DHGSPPLSA---------SASVTVTVLDVNDNRPEFT 827
Score = 98.3 bits (234), Expect = 2e-19
Identities = 119/497 (23%), Positives = 205/497 (41%), Gaps = 56/497 (11%)
Query: 858 KIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFT 917
++ Y L+ VA DT + + A + + D + + R H L+ +A T
Sbjct: 755 RLEYSLTGVAPDTPFVINSATGWVSVSGPLDRE-SVEHYFFGVEARDHGSPPLSASASVT 813
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
+ V N + + E+ +GT+++ + A+D D+ N I Y+
Sbjct: 814 VT-VLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSAISYQITGG---- 866
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLP----PESEFRLNISALDGGNLNDNISVRV 1033
+ F I+ + G +V +LP E F+L ++A D L+D+ V +
Sbjct: 867 ---------NTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-LHDHCYVHI 916
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPF 1093
+ D N H PVF+ Y+ +V E + + + A+D D G+NA +TY ++ D F
Sbjct: 917 NITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLE--DNLPQF 974
Query: 1094 EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYA 1153
I +G +++ LD E + Y L + ARDNG DVNDN+P+F A
Sbjct: 975 RIDADSGAITLQAPLDYEDQVTYTLAITARDNG-IPQKADTTYVEVMVNDVNDNAPQFVA 1033
Query: 1154 --FDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN 1211
+ L+ P F SV+ I N + T D DF
Sbjct: 1034 SHYTGLVSEDAPP--------FTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPT 1085
Query: 1212 GLILYSLPQRKNQQ-----------NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISR 1260
I+ ++ + + + G+P L + + V V DV D + PVF +
Sbjct: 1086 SGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVND-----NAPVFPAE 1140
Query: 1261 YYELEIEEN--VNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLV 1318
+E+ ++EN V + V ++ + N + Y I+ N I F +D +G L +
Sbjct: 1141 EFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGN---IPELFQMDIFSGELTAL 1197
Query: 1319 RSPDREVKDTYEVIVRA 1335
D E + Y ++V+A
Sbjct: 1198 IDLDYEARQEYVIVVQA 1214
Score = 96.7 bits (230), Expect = 6e-19
Identities = 115/427 (26%), Positives = 176/427 (41%), Gaps = 43/427 (10%)
Query: 905 HRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNG 964
H +L+ T + V +N + +Q + EN+ G I++L A D D+ N
Sbjct: 478 HGSPRLSATT-MVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNA 536
Query: 965 QIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDG 1022
+RY F PP+ +A A F I+ R G + + + E + L + A D
Sbjct: 537 NLRYRFVG----PPAARAAAAAA----FEIDPRSGLISTSGRVDREHMESYELVVEASDQ 588
Query: 1023 GN----LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNA 1078
G + + V + V D ND+ P F + Y V E V+ +V ATD D N
Sbjct: 589 GQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANG 648
Query: 1079 NLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXX 1138
+ Y I ++ F I LTG + V LD E E +Y L + A+D G
Sbjct: 649 LVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLAS 708
Query: 1139 XXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNF-ESVMMIPVYKATIEENAPIGTTVA 1197
D+ND+ P F + + L N SV+ I A ENA + ++
Sbjct: 709 IQVVDINDHIPIFVSTPF-------QVSVLENAPLGHSVIHIQAVDADHGENARLEYSLT 761
Query: 1198 KVFANDTDF-IGNGNGLILYSLP-QRKNQQNL---------GLPSLSSTAILMVTVADVP 1246
V A DT F I + G + S P R++ ++ G P LS++A + VTV DV
Sbjct: 762 GV-APDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVN 820
Query: 1247 DEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTF 1306
D ++P F + Y L + E+ +VS+ + N + Y I N R F
Sbjct: 821 D-----NRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGN---TRNRF 872
Query: 1307 VIDPRNG 1313
I + G
Sbjct: 873 AISTQGG 879
Score = 93.5 bits (222), Expect = 5e-18
Identities = 52/159 (32%), Positives = 83/159 (52%), Gaps = 10/159 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D+D + Y +ISGN R F++DS+ G + + LD +AE + L+++
Sbjct: 637 VTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAERE-----YALRIR 691
Query: 278 ASQLNNP-LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A P L I+++D+ND++P F + +S++EN P G SV+ + A D D G
Sbjct: 692 AQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHG 751
Query: 337 ENGEFTYQLDD--PKGAFSIDPRSGWLTVRNQTVLDREA 373
EN Y L P F I+ +GW++V LDRE+
Sbjct: 752 ENARLEYSLTGVAPDTPFVINSATGWVSVSGP--LDRES 788
Score = 89.8 bits (213), Expect = 6e-17
Identities = 194/834 (23%), Positives = 317/834 (38%), Gaps = 113/834 (13%)
Query: 571 PDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDL--LHGYEEGVPFAVEERS 626
P F Y+ V N GT+V ++ D A E + Y L L F+++ +S
Sbjct: 393 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 452
Query: 627 GVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLLKGAHSPII 685
G+I L R + + A + LS T V V D ND V + + +
Sbjct: 453 GLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETL 512
Query: 686 FHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED---GTIFTQ 741
+EN G I Q+ T+ N RF+ A D G I T
Sbjct: 513 ---RENVEEGYPILQLRATD-GDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTS 568
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISG--AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN 799
+DRE + Y + V A ++G G + +V I + DENDN P F Y + E+
Sbjct: 569 GRVDREHMESYELVVEAS-DQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRED 627
Query: 800 SKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKI 859
+ T +++ T D +A G +++ F DSL E ++
Sbjct: 628 VRPHTV-----VLRVTATDRDKDA--------NGLVHYNIISGNSRGHFAIDSLTGEIQV 674
Query: 860 MYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTII 919
+ L A E E + I ++ +P + N+ G A ++
Sbjct: 675 VAPLDFEA--------EREYALRIRAQDAGRPP---LSNNT-----------GLASIQVV 712
Query: 920 EVKPKNKFALDVD-QLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
++ + Q+ L EN P+G ++I + A+D D G N ++ Y P
Sbjct: 713 DINDHIPIFVSTPFQVSVL----ENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTP 768
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVF 1034
FVIN G V V+ L ES + + A D G+ L+ + SV V
Sbjct: 769 -------------FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVT 815
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFE 1094
V DVND+ P F Y+ + E + V A D D N+ ++Y I +T F
Sbjct: 816 VLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFA 873
Query: 1095 ISPL--TGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY 1152
IS G++++ LD + E +Y V+ + D N + P F
Sbjct: 874 ISTQGGVGLVTLALPLDYKQE-RYFKLVLTASD---RALHDHCYVHINITDANTHRPVFQ 929
Query: 1153 A--FDELLEWKHPEADELS--NHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIG 1208
+ + + P + + + + V +E+N P A A
Sbjct: 930 SAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPL 989
Query: 1209 NGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEE 1268
+ + Y+L G+P + T + V V DV D P F++ +Y + E
Sbjct: 990 DYEDQVTYTLAITARDN--GIPQKADTTYVEVMVNDVNDNA-----PQFVASHYTGLVSE 1042
Query: 1269 NVNAPVELVSLNLTEH--YENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVK 1326
+ ++ ++ T+ + N +++Y N D D F I+P +G + VR DRE
Sbjct: 1043 DAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGD--GDFTIEPTSGIVRTVRRLDREAV 1100
Query: 1327 DTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF 1380
YE+ A R +P + PV+ + V ++DVNDN+P F
Sbjct: 1101 SVYELTAYA----VDRGVPPLRTPVS-------------IQVMVQDVNDNAPVF 1137
Score = 87.0 bits (206), Expect = 5e-16
Identities = 122/461 (26%), Positives = 191/461 (41%), Gaps = 76/461 (16%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPL 132
G +SA SVTV + DVNDN P F YH+ ++E A +G S+
Sbjct: 802 GSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNE------------DAAVGTSVV--- 846
Query: 133 TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLL-LRKVLDYD 191
+ A DRD NS + Y I GN FA+ + L+ L LDY
Sbjct: 847 ----------SVTAVDRD----ANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYK 892
Query: 192 AGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSL----- 246
++ F+LV+ AS + +H I + V + Y + DR + S
Sbjct: 893 Q-ERYFKLVLTASDRALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVIS 951
Query: 247 -------DSVNGSLFLEKELD---LDAEH---NLQAN-------TFVLQVQASQLNNPLK 286
++ + LE L +DA+ LQA T+ L + A P K
Sbjct: 952 ASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQK 1011
Query: 287 TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG--EFTYQ 344
VE+ + D+NDN P+F Y + E+ P SVLQ+ ATD+D NG ++T+Q
Sbjct: 1012 ADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQ 1071
Query: 345 L-DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGTFADSQRIAKW 403
+D G F+I+P SG VR LDREA S + YA + + T Q +
Sbjct: 1072 NGEDGDGDFTIEPTSG--IVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMV-- 1127
Query: 404 RRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSN 463
Q + NAP VFP + + + ++ V ++T +D ++ +
Sbjct: 1128 --QDVNDNAP------VFP----AEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQ 1175
Query: 464 LYEFSMKSNAKVGTVIGKVKA-VDPDLGQNGMVLYDLQRTS 503
+ E ++ ++ G++ A +D D + +Q TS
Sbjct: 1176 IVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATS 1216
Score = 83.0 bits (196), Expect = 7e-15
Identities = 82/311 (26%), Positives = 137/311 (44%), Gaps = 22/311 (7%)
Query: 84 TVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIF--LIAPIGPS--LTIPLT--VPRG 137
++ + D+ND++PIF+ TP+ V+V E P G + A G + L LT P
Sbjct: 708 SIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDT 767
Query: 138 LTIFKDIRAF-DRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
+ + P S HY V D G L +S + VLD +
Sbjct: 768 PFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVT---VLDVNDNRP 824
Query: 196 EFQLVIMASGKRIHKEILFPEPIHAIDQ-DLGVGATLRYELISGNDRKLFSLDSVNGSLF 254
EF + R++++ + ++ D + + Y++ GN R F++ + G
Sbjct: 825 EFTM--KEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGL 882
Query: 255 LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNIS 314
+ L LD + Q F L + AS + L V I + D N + P F+ Y++S
Sbjct: 883 VTLALPLDYK---QERYFKLVLTAS--DRALHD-HCYVHINITDANTHRPVFQSAHYSVS 936
Query: 315 IVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAH 374
+ E+ P G +++ + A+D D GEN TY L+D F ID SG +T+ Q LD E
Sbjct: 937 VNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITL--QAPLDYEDQ 994
Query: 375 SSLRMKVYAKE 385
+ + + A++
Sbjct: 995 VTYTLAITARD 1005
Score = 77.8 bits (183), Expect = 3e-13
Identities = 65/224 (29%), Positives = 100/224 (44%), Gaps = 22/224 (9%)
Query: 939 LIPENIPIGTTIIKLNALDLDSGLNGQIRYEF-NSEVYIPPSKLSADALEVKRYFVINER 997
L+ E+ P T++++++A D D+ NG+++Y F N E D F I
Sbjct: 1039 LVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGE--------DGDG-----DFTIEPT 1085
Query: 998 HGHVIVARSLPPE--SEFRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFN 1053
G V R L E S + L A+D G L +S++V V+DVND+ PVF +
Sbjct: 1086 SGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVR 1145
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETE 1113
V+E V+ ++ A D D G NA++ Y I + F++ +G L+ +LD E
Sbjct: 1146 VKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEAR 1205
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDEL 1157
+Y++ V A D NDNSP F L
Sbjct: 1206 QEYVIVVQA----TSAPLVSRATVHVRLVDQNDNSPVLNNFQIL 1245
Score = 76.6 bits (180), Expect = 6e-13
Identities = 107/452 (23%), Positives = 185/452 (40%), Gaps = 44/452 (9%)
Query: 436 DEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMV 495
D L V + + DAN + PVF ++ Y S+ + +G+ I + A D D+G+N +
Sbjct: 905 DRALHDHCYVHINITDANTHRPVFQSAH-YSVSVNEDRPMGSTIVVISASDDDVGENARI 963
Query: 496 LYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVV 555
Y L+ NL F+I+ ++G +++ ++P+ + A N ++ V
Sbjct: 964 TYLLE--DNL---PQFRIDADSGAITL-QAPLDYEDQVTYTLAITARDNGIPQKADTTYV 1017
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHG 613
+ V + P F+ + Y V + TSV QI DA V Y +G
Sbjct: 1018 EVMV----NDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNG 1073
Query: 614 YEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDE 672
+ F +E SG++ V L R +Y+ A A+ L + V V DVND
Sbjct: 1074 EDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDN 1133
Query: 673 RGVLLKGAHSPIIFHVKENS-AGAAIGQIFHT------NMSSIYGNGTGNVRFLIANQQD 725
V VKENS G+ + QI N +Y GN+ L Q D
Sbjct: 1134 APVF---PAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELF--QMD 1188
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP 785
+ G + LD E R Y + V+ + ++S A ++ + + D+NDN P
Sbjct: 1189 IF-------SGELTALIDLDYEARQEY-VIVVQATSAPLVSRATVH---VRLVDQNDNSP 1237
Query: 786 VFEH--ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENT 843
V + + ++ S + I A D D + + + G ++ V++ +
Sbjct: 1238 VLNNFQILFNNYVSNRSDTFPS-GIIGRIPAYDPDVSDHLFYSFER-GNELQLLVVNQTS 1295
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTGGLSS 875
G ++ + LD + ++ S++ T GL S
Sbjct: 1296 GELR-LSRKLDNNRPLV--ASMLVTVTDGLHS 1324
Score = 68.5 bits (160), Expect = 2e-10
Identities = 53/176 (30%), Positives = 80/176 (45%), Gaps = 17/176 (9%)
Query: 220 AIDQDLGVGATLRYEL---ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
A D D G L Y L ++ +LFS+D +G + LD ++ L+V
Sbjct: 419 AQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDRESMER-----HYLRV 473
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A +P +A V + + D ND+ P FE Y ++ EN+ G+ +LQ+ ATD D
Sbjct: 474 TAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAP 533
Query: 337 ENGEFTYQLDDP-------KGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N Y+ P AF IDPRSG ++ + +DRE S + V A +
Sbjct: 534 PNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGR--VDREHMESYELVVEASD 587
Score = 58.8 bits (136), Expect = 1e-07
Identities = 65/236 (27%), Positives = 105/236 (44%), Gaps = 20/236 (8%)
Query: 160 HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPE-PI 218
HY V+ D G L ++ ++ V D + F+ R + E +P +
Sbjct: 469 HYLRVTAQDHGSPRLSAT---TMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPILQL 525
Query: 219 HAIDQDLGVGATLRYELISGNDRKL-----FSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
A D D A LRY + + F +D +G + +D EH ++
Sbjct: 526 RATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVD--REH---MESYE 580
Query: 274 LQVQAS-QLNNP-LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMAT 331
L V+AS Q P ++A RV I +LD NDN P+F Y + E++ VL+V AT
Sbjct: 581 LVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTAT 640
Query: 332 DKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D+D+ NG Y + + +G F+ID +G + V LD EA +++ A++
Sbjct: 641 DRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQV--VAPLDFEAEREYALRIRAQD 694
Score = 57.2 bits (132), Expect = 4e-07
Identities = 96/408 (23%), Positives = 161/408 (39%), Gaps = 62/408 (15%)
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQP--SDTDL 1091
F + N H P F + Y V E + + +V A D D G+ L Y + + L
Sbjct: 385 FRRAANRH-PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSL 443
Query: 1092 P-FEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
F I P +G++ LDRE+ +++ L V A+D+G D ND+SP
Sbjct: 444 ELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHG-SPRLSATTMVAVTVADRNDHSPV 502
Query: 1151 FYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAP--------IGTTVAKVFAN 1202
F E +++ E N E I +AT + P +G A+ A
Sbjct: 503 F----EQAQYR-----ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAA 553
Query: 1203 DTDFIGNGNGLI------------LYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVE 1250
I +GLI Y L + Q S+T + +TV D E
Sbjct: 554 AAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLD-----E 608
Query: 1251 MSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFVI 1308
+ P F + Y ++ E+V ++ + T+ + N + Y I++ N R F I
Sbjct: 609 NDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNS---RGHFAI 665
Query: 1309 DPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVV 1368
D G + +V D E + Y + +RA Q R P++ + G+ +
Sbjct: 666 DSLTGEIQVVAPLDFEAEREYALRIRA--QDAGRP------PLSNNT--GLAS------I 709
Query: 1369 RIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQLKGAIGHHPTASR 1416
++ D+ND+ P F + P ++ AP G+ V+ ++ H +R
Sbjct: 710 QVVDINDHIPIFV--STPFQVSVLENAPLGHSVIHIQAVDADHGENAR 755
Score = 54.0 bits (124), Expect = 4e-06
Identities = 45/169 (26%), Positives = 85/169 (50%), Gaps = 14/169 (8%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I A+D D G A + Y+++ GN +LF +D +G L +LD +A +V+ VQ
Sbjct: 1159 ITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQE-----YVIVVQ 1213
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLP---EFEVDFYNI--SIVENLPNGFSVLQVMATD 332
A+ PL ++A V + L+D NDN P F++ F N + + P+G + ++ A D
Sbjct: 1214 ATSA--PL-VSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGI-IGRIPAYD 1269
Query: 333 KDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKV 381
D ++ ++++ + ++ SG L + + +R +S+ + V
Sbjct: 1270 PDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTV 1318
Score = 46.4 bits (105), Expect = 8e-04
Identities = 31/87 (35%), Positives = 44/87 (50%), Gaps = 7/87 (8%)
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGA-----FSIDPRS 358
P+F Y + EN G +VL+V+A D D GE G Y L + FSIDP+S
Sbjct: 393 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 452
Query: 359 GWLTVRNQTVLDREAHSSLRMKVYAKE 385
G +R LDRE+ ++V A++
Sbjct: 453 G--LIRTAAALDRESMERHYLRVTAQD 477
Score = 44.0 bits (99), Expect = 0.004
Identities = 26/65 (40%), Positives = 40/65 (61%), Gaps = 4/65 (6%)
Query: 139 TIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQ 198
T+ + A DRDK N VHY+I+SGN GHFA++S + ++ LD++A ++E+
Sbjct: 632 TVVLRVTATDRDKD--ANGLVHYNIISGNSRGHFAIDSLTGEIQVVAP-LDFEA-EREYA 687
Query: 199 LVIMA 203
L I A
Sbjct: 688 LRIRA 692
Score = 33.9 bits (74), Expect = 4.5
Identities = 17/39 (43%), Positives = 24/39 (61%), Gaps = 1/39 (2%)
Query: 1441 ATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAAL 1479
A+D D+G NA I Y +L + P+F ID SG + + A L
Sbjct: 952 ASDDDVGENARITY-LLEDNLPQFRIDADSGAITLQAPL 989
>AF231023-1|AAF61929.1| 3312|Homo sapiens protocadherin Flamingo 1
protein.
Length = 3312
Score = 118 bits (285), Expect = 1e-25
Identities = 134/487 (27%), Positives = 217/487 (44%), Gaps = 39/487 (8%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L + +V VT+LD NDN P F Y + +A VGT + V AVD D N + Y
Sbjct: 736 LSASASVTVTVLDVNDNRPEFTMKE-YHLRLNEDAAVGTSVVSVTAVDRDA--NSAISYQ 792
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERR-YSLAVVTI 557
+ T T + F I+ G V + L+ + + + S+R + V I
Sbjct: 793 I--TGGNT-RNRFAISTQGGVGLVTLALPLDYKQERYFKLV---LTASDRALHDHCYVHI 846
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGY--E 615
+T P F A Y V + +G+++ I +D +DV + Y E
Sbjct: 847 NITDANTHR----PVFQSAHYSVSVNEDRPMGSTIVVISASD----DDVGENARITYLLE 898
Query: 616 EGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA--NLSIVTNATVHVVDVNDE 672
+ +P F ++ SG IT+ L ++ Y A+ ++N + T V V DVND
Sbjct: 899 DNLPQFRIDADSGAITLQAPLDYEDQVTYTL-AITARDNGIPQKADTTYVEVMVNDVNDN 957
Query: 673 RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI 732
+ ++ ++ ++ ++ QI T+ + + G V++ N +D D I
Sbjct: 958 APQFVASHYTGLVS--EDAPPFTSVLQISATDRDA---HANGRVQYTFQNGEDGDGDFTI 1012
Query: 733 AE-DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
G + T + LDRE VY +T A ++GV + + ++D NDN PVF
Sbjct: 1013 EPTSGIVRTVRRLDREAVSVYELTAYA-VDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEE 1071
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTGVVKFIG 850
+E + ENS +G+ + I A D DEG NA MY + G E+F +D +G + +
Sbjct: 1072 FEVRVKENSIVGSVVAQ---ITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALI 1128
Query: 851 DSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFN--QIEENSKVRIHRET 908
D LD E + Y + +V + L S A + + + D+NDN P N QI N+ V +T
Sbjct: 1129 D-LDYEARQEYVI-VVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDT 1186
Query: 909 KLNGTAG 915
+G G
Sbjct: 1187 FPSGIIG 1193
Score = 109 bits (261), Expect = 1e-22
Identities = 118/458 (25%), Positives = 188/458 (41%), Gaps = 27/458 (5%)
Query: 452 ANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPF 511
A + +P F P Y+ + N GT + +V A DPD G+ G ++Y L N F
Sbjct: 318 AANRHPQF-PQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELF 376
Query: 512 KINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPD 569
I+P +G + A + E RH L V A D +P ++ VT+
Sbjct: 377 SIDPQSGLIRTAAALDRESMERHYLRVTAQDH-GSPRLSATTMVAVTV------ADRNDH 429
Query: 570 IPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLL----HGYEEGVPFAVE 623
P F A Y + NV G + Q+R DA ++ Y + F ++
Sbjct: 430 SPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEID 489
Query: 624 ERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHV-VDVNDERGVLLKGAHS 682
RSG+I+ + R + Y+ V + +ATV V + V DE + +
Sbjct: 490 PRSGLISTSGRVDREHMESYEL-VVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEK 548
Query: 683 PIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQK 742
+ V+E+ + + + + G V + I + + G I
Sbjct: 549 RYVAQVREDVRPHTV--VLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVA 606
Query: 743 PLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKI 802
PLD E Y + + A+ +I + D ND+ P+F ++ ++EN+ +
Sbjct: 607 PLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPL 666
Query: 803 GTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM-FDVDENTGVVKFIGDSLDREKKIMY 861
G + I+A DAD G NA Y+L G + F ++ TG V G LDRE Y
Sbjct: 667 GHSVIH---IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSG-PLDRESVEHY 722
Query: 862 KLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIE 897
+ ARD G LS+ A + + + D NDN+PEF E
Sbjct: 723 FFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKE 760
Score = 103 bits (246), Expect = 7e-21
Identities = 119/481 (24%), Positives = 198/481 (41%), Gaps = 33/481 (6%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L + V VT+ D ND++PVF + Y +++ N + G I +++A D D N + Y
Sbjct: 412 RLSATTMVAVTVADRNDHSPVFEQAQ-YRETLRENVEEGYPILQLRATDGDAPPNANLRY 470
Query: 498 DL--QRTSNLTITSPFKINPNTGTVSVAESPILEGRHA--LFVEASDQPANPSERRYSLA 553
+ + F+I+P +G +S + E + L VEASDQ P R A
Sbjct: 471 RFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRS---A 527
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND--VSYDLL 611
V + +T + P F Y V +V T V ++ D + + V Y+++
Sbjct: 528 TVRVHIT--VLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNII 585
Query: 612 HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTN---ATVHVVD 668
G G FA++ +G I VV L Y + Q+ + N A++ VVD
Sbjct: 586 SGNSRG-HFAIDSLTGEIQVVAPLDFEAEREYALR-IRAQDAGRPPLSNNTGLASIQVVD 643
Query: 669 VNDERGVLLKGAHSPIIFHVKENSAGAAIGQ-IFHTNMSSIYGNGTGNVRFLIANQQDVT 727
+ND + + +P V EN A +G + H + + + T
Sbjct: 644 INDHIPIFVS---TPFQVSVLEN---APLGHSVIHIQAVDADHGENARLEYSLTGVAPDT 697
Query: 728 DDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVF 787
+ + G + PLDRE + Y V A + G + VT+ + D NDN P F
Sbjct: 698 PFVINSATGWVSVSGPLDRESVEHYFFGVEAR-DHGSPPLSASASVTVTVLDVNDNRPEF 756
Query: 788 EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTGV- 845
Y + E++ +GT +++ T D N+ Y + G + F + GV
Sbjct: 757 TMKEYHLRLNEDAAVGT-----SVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVG 811
Query: 846 VKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIH 905
+ + LD +++ +KL L A D L + I I D N ++P F + V
Sbjct: 812 LVTLALPLDYKQERYFKLVLTASDR-ALHDHCYVHINITDANTHRPVFQSAHYSVSVNED 870
Query: 906 R 906
R
Sbjct: 871 R 871
Score = 99.5 bits (237), Expect = 8e-20
Identities = 123/467 (26%), Positives = 201/467 (43%), Gaps = 66/467 (14%)
Query: 939 LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERH 998
L+PEN GT ++++ A D D+G G++ VY + +++ +LE+ F I+ +
Sbjct: 333 LVPENEAAGTAVLRVVAQDPDAGEAGRL-------VYSLAALMNSRSLEL---FSIDPQS 382
Query: 999 GHVIVARSLPPESEFR--LNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNV 1054
G + A +L ES R L ++A D G+ L+ V V V D NDH PVF++ Y +
Sbjct: 383 GLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETL 442
Query: 1055 EEAQYTRRVLGKVDATDADFGQNANLTY-FIQP----SDTDLPFEISPLTGVLSVNGELD 1109
E + ++ ATD D NANL Y F+ P + FEI P +G++S +G +D
Sbjct: 443 RENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVD 502
Query: 1110 RETEDKYILTVVARDNGXX-XXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADEL 1168
RE + Y L V A D G D NDN+P+F + + + +++
Sbjct: 503 REHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVR----EDV 558
Query: 1169 SNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLP--------- 1219
H V+ + + N + + + I + G I P
Sbjct: 559 RPHTV--VLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREY 616
Query: 1220 -QRKNQQNLGLPSLS-STAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELV 1277
R Q+ G P LS +T + + V D+ D + P+F+S +++ + EN ++
Sbjct: 617 ALRIRAQDAGRPPLSNNTGLASIQVVDINDHI-----PIFVSTPFQVSVLENAPLGHSVI 671
Query: 1278 SLNL--TEHYENFKMRYYILN-ENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVR 1334
+ +H EN ++ Y + DT FVI+ G + + DRE + Y V
Sbjct: 672 HIQAVDADHGENARLEYSLTGVAPDT----PFVINSATGWVSVSGPLDRESVEHYFFGVE 727
Query: 1335 AERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A H P++ V V + DVNDN P+FT
Sbjct: 728 AR--------DHGSPPLSA---------SASVTVTVLDVNDNRPEFT 757
Score = 98.3 bits (234), Expect = 2e-19
Identities = 119/497 (23%), Positives = 205/497 (41%), Gaps = 56/497 (11%)
Query: 858 KIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFT 917
++ Y L+ VA DT + + A + + D + + R H L+ +A T
Sbjct: 685 RLEYSLTGVAPDTPFVINSATGWVSVSGPLDRE-SVEHYFFGVEARDHGSPPLSASASVT 743
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
+ V N + + E+ +GT+++ + A+D D+ N I Y+
Sbjct: 744 VT-VLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSAISYQITGG---- 796
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLP----PESEFRLNISALDGGNLNDNISVRV 1033
+ F I+ + G +V +LP E F+L ++A D L+D+ V +
Sbjct: 797 ---------NTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-LHDHCYVHI 846
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPF 1093
+ D N H PVF+ Y+ +V E + + + A+D D G+NA +TY ++ D F
Sbjct: 847 NITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLE--DNLPQF 904
Query: 1094 EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYA 1153
I +G +++ LD E + Y L + ARDNG DVNDN+P+F A
Sbjct: 905 RIDADSGAITLQAPLDYEDQVTYTLAITARDNG-IPQKADTTYVEVMVNDVNDNAPQFVA 963
Query: 1154 --FDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN 1211
+ L+ P F SV+ I N + T D DF
Sbjct: 964 SHYTGLVSEDAPP--------FTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPT 1015
Query: 1212 GLILYSLPQRKNQQ-----------NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISR 1260
I+ ++ + + + G+P L + + V V DV D + PVF +
Sbjct: 1016 SGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVND-----NAPVFPAE 1070
Query: 1261 YYELEIEEN--VNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLV 1318
+E+ ++EN V + V ++ + N + Y I+ N I F +D +G L +
Sbjct: 1071 EFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGN---IPELFQMDIFSGELTAL 1127
Query: 1319 RSPDREVKDTYEVIVRA 1335
D E + Y ++V+A
Sbjct: 1128 IDLDYEARQEYVIVVQA 1144
Score = 96.7 bits (230), Expect = 6e-19
Identities = 115/427 (26%), Positives = 176/427 (41%), Gaps = 43/427 (10%)
Query: 905 HRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNG 964
H +L+ T + V +N + +Q + EN+ G I++L A D D+ N
Sbjct: 408 HGSPRLSATT-MVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNA 466
Query: 965 QIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDG 1022
+RY F PP+ +A A F I+ R G + + + E + L + A D
Sbjct: 467 NLRYRFVG----PPAARAAAAAA----FEIDPRSGLISTSGRVDREHMESYELVVEASDQ 518
Query: 1023 GN----LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNA 1078
G + + V + V D ND+ P F + Y V E V+ +V ATD D N
Sbjct: 519 GQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANG 578
Query: 1079 NLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXX 1138
+ Y I ++ F I LTG + V LD E E +Y L + A+D G
Sbjct: 579 LVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLAS 638
Query: 1139 XXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNF-ESVMMIPVYKATIEENAPIGTTVA 1197
D+ND+ P F + + L N SV+ I A ENA + ++
Sbjct: 639 IQVVDINDHIPIFVSTPF-------QVSVLENAPLGHSVIHIQAVDADHGENARLEYSLT 691
Query: 1198 KVFANDTDF-IGNGNGLILYSLP-QRKNQQNL---------GLPSLSSTAILMVTVADVP 1246
V A DT F I + G + S P R++ ++ G P LS++A + VTV DV
Sbjct: 692 GV-APDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVN 750
Query: 1247 DEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTF 1306
D ++P F + Y L + E+ +VS+ + N + Y I N R F
Sbjct: 751 D-----NRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGN---TRNRF 802
Query: 1307 VIDPRNG 1313
I + G
Sbjct: 803 AISTQGG 809
Score = 93.5 bits (222), Expect = 5e-18
Identities = 52/159 (32%), Positives = 83/159 (52%), Gaps = 10/159 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D+D + Y +ISGN R F++DS+ G + + LD +AE + L+++
Sbjct: 567 VTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAERE-----YALRIR 621
Query: 278 ASQLNNP-LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A P L I+++D+ND++P F + +S++EN P G SV+ + A D D G
Sbjct: 622 AQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHG 681
Query: 337 ENGEFTYQLDD--PKGAFSIDPRSGWLTVRNQTVLDREA 373
EN Y L P F I+ +GW++V LDRE+
Sbjct: 682 ENARLEYSLTGVAPDTPFVINSATGWVSVSGP--LDRES 718
Score = 89.8 bits (213), Expect = 6e-17
Identities = 194/834 (23%), Positives = 317/834 (38%), Gaps = 113/834 (13%)
Query: 571 PDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDL--LHGYEEGVPFAVEERS 626
P F Y+ V N GT+V ++ D A E + Y L L F+++ +S
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
Query: 627 GVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLLKGAHSPII 685
G+I L R + + A + LS T V V D ND V + + +
Sbjct: 383 GLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETL 442
Query: 686 FHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED---GTIFTQ 741
+EN G I Q+ T+ N RF+ A D G I T
Sbjct: 443 ---RENVEEGYPILQLRATD-GDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTS 498
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISG--AGIYQVTIYIEDENDNPPVFEHATYEGFIMEN 799
+DRE + Y + V A ++G G + +V I + DENDN P F Y + E+
Sbjct: 499 GRVDREHMESYELVVEAS-DQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRED 557
Query: 800 SKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKI 859
+ T +++ T D +A G +++ F DSL E ++
Sbjct: 558 VRPHTV-----VLRVTATDRDKDA--------NGLVHYNIISGNSRGHFAIDSLTGEIQV 604
Query: 860 MYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTII 919
+ L A E E + I ++ +P + N+ G A ++
Sbjct: 605 VAPLDFEA--------EREYALRIRAQDAGRPP---LSNNT-----------GLASIQVV 642
Query: 920 EVKPKNKFALDVD-QLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
++ + Q+ L EN P+G ++I + A+D D G N ++ Y P
Sbjct: 643 DINDHIPIFVSTPFQVSVL----ENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTP 698
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVF 1034
FVIN G V V+ L ES + + A D G+ L+ + SV V
Sbjct: 699 -------------FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVT 745
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFE 1094
V DVND+ P F Y+ + E + V A D D N+ ++Y I +T F
Sbjct: 746 VLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFA 803
Query: 1095 ISPL--TGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY 1152
IS G++++ LD + E +Y V+ + D N + P F
Sbjct: 804 ISTQGGVGLVTLALPLDYKQE-RYFKLVLTASD---RALHDHCYVHINITDANTHRPVFQ 859
Query: 1153 A--FDELLEWKHPEADELS--NHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIG 1208
+ + + P + + + + V +E+N P A A
Sbjct: 860 SAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPL 919
Query: 1209 NGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEE 1268
+ + Y+L G+P + T + V V DV D P F++ +Y + E
Sbjct: 920 DYEDQVTYTLAITARDN--GIPQKADTTYVEVMVNDVNDNA-----PQFVASHYTGLVSE 972
Query: 1269 NVNAPVELVSLNLTEH--YENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVK 1326
+ ++ ++ T+ + N +++Y N D D F I+P +G + VR DRE
Sbjct: 973 DAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGD--GDFTIEPTSGIVRTVRRLDREAV 1030
Query: 1327 DTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF 1380
YE+ A R +P + PV+ + V ++DVNDN+P F
Sbjct: 1031 SVYELTAYA----VDRGVPPLRTPVS-------------IQVMVQDVNDNAPVF 1067
Score = 87.0 bits (206), Expect = 5e-16
Identities = 122/461 (26%), Positives = 191/461 (41%), Gaps = 76/461 (16%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPL 132
G +SA SVTV + DVNDN P F YH+ ++E A +G S+
Sbjct: 732 GSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNE------------DAAVGTSVV--- 776
Query: 133 TVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLL-LRKVLDYD 191
+ A DRD NS + Y I GN FA+ + L+ L LDY
Sbjct: 777 ----------SVTAVDRD----ANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYK 822
Query: 192 AGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSL----- 246
++ F+LV+ AS + +H I + V + Y + DR + S
Sbjct: 823 Q-ERYFKLVLTASDRALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVIS 881
Query: 247 -------DSVNGSLFLEKELD---LDAEH---NLQAN-------TFVLQVQASQLNNPLK 286
++ + LE L +DA+ LQA T+ L + A P K
Sbjct: 882 ASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQK 941
Query: 287 TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG--EFTYQ 344
VE+ + D+NDN P+F Y + E+ P SVLQ+ ATD+D NG ++T+Q
Sbjct: 942 ADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQ 1001
Query: 345 L-DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGTFADSQRIAKW 403
+D G F+I+P SG VR LDREA S + YA + + T Q +
Sbjct: 1002 NGEDGDGDFTIEPTSG--IVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMV-- 1057
Query: 404 RRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSN 463
Q + NAP VFP + + + ++ V ++T +D ++ +
Sbjct: 1058 --QDVNDNAP------VFP----AEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQ 1105
Query: 464 LYEFSMKSNAKVGTVIGKVKA-VDPDLGQNGMVLYDLQRTS 503
+ E ++ ++ G++ A +D D + +Q TS
Sbjct: 1106 IVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATS 1146
Score = 83.0 bits (196), Expect = 7e-15
Identities = 82/311 (26%), Positives = 137/311 (44%), Gaps = 22/311 (7%)
Query: 84 TVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIF--LIAPIGPS--LTIPLT--VPRG 137
++ + D+ND++PIF+ TP+ V+V E P G + A G + L LT P
Sbjct: 638 SIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDT 697
Query: 138 LTIFKDIRAF-DRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAGDK 195
+ + P S HY V D G L +S + VLD +
Sbjct: 698 PFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVT---VLDVNDNRP 754
Query: 196 EFQLVIMASGKRIHKEILFPEPIHAIDQ-DLGVGATLRYELISGNDRKLFSLDSVNGSLF 254
EF + R++++ + ++ D + + Y++ GN R F++ + G
Sbjct: 755 EFTM--KEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGL 812
Query: 255 LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNIS 314
+ L LD + Q F L + AS + L V I + D N + P F+ Y++S
Sbjct: 813 VTLALPLDYK---QERYFKLVLTAS--DRALHD-HCYVHINITDANTHRPVFQSAHYSVS 866
Query: 315 IVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAH 374
+ E+ P G +++ + A+D D GEN TY L+D F ID SG +T+ Q LD E
Sbjct: 867 VNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITL--QAPLDYEDQ 924
Query: 375 SSLRMKVYAKE 385
+ + + A++
Sbjct: 925 VTYTLAITARD 935
Score = 77.8 bits (183), Expect = 3e-13
Identities = 65/224 (29%), Positives = 100/224 (44%), Gaps = 22/224 (9%)
Query: 939 LIPENIPIGTTIIKLNALDLDSGLNGQIRYEF-NSEVYIPPSKLSADALEVKRYFVINER 997
L+ E+ P T++++++A D D+ NG+++Y F N E D F I
Sbjct: 969 LVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGE--------DGDG-----DFTIEPT 1015
Query: 998 HGHVIVARSLPPE--SEFRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFN 1053
G V R L E S + L A+D G L +S++V V+DVND+ PVF +
Sbjct: 1016 SGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVR 1075
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETE 1113
V+E V+ ++ A D D G NA++ Y I + F++ +G L+ +LD E
Sbjct: 1076 VKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEAR 1135
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDEL 1157
+Y++ V A D NDNSP F L
Sbjct: 1136 QEYVIVVQA----TSAPLVSRATVHVRLVDQNDNSPVLNNFQIL 1175
Score = 76.6 bits (180), Expect = 6e-13
Identities = 107/452 (23%), Positives = 185/452 (40%), Gaps = 44/452 (9%)
Query: 436 DEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMV 495
D L V + + DAN + PVF ++ Y S+ + +G+ I + A D D+G+N +
Sbjct: 835 DRALHDHCYVHINITDANTHRPVFQSAH-YSVSVNEDRPMGSTIVVISASDDDVGENARI 893
Query: 496 LYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVV 555
Y L+ NL F+I+ ++G +++ ++P+ + A N ++ V
Sbjct: 894 TYLLE--DNL---PQFRIDADSGAITL-QAPLDYEDQVTYTLAITARDNGIPQKADTTYV 947
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHG 613
+ V + P F+ + Y V + TSV QI DA V Y +G
Sbjct: 948 EVMV----NDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNG 1003
Query: 614 YEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDE 672
+ F +E SG++ V L R +Y+ A A+ L + V V DVND
Sbjct: 1004 EDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDN 1063
Query: 673 RGVLLKGAHSPIIFHVKENS-AGAAIGQIFHT------NMSSIYGNGTGNVRFLIANQQD 725
V VKENS G+ + QI N +Y GN+ L Q D
Sbjct: 1064 APVF---PAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELF--QMD 1118
Query: 726 VTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP 785
+ G + LD E R Y + V+ + ++S A ++ + + D+NDN P
Sbjct: 1119 IF-------SGELTALIDLDYEARQEY-VIVVQATSAPLVSRATVH---VRLVDQNDNSP 1167
Query: 786 VFEH--ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENT 843
V + + ++ S + I A D D + + + G ++ V++ +
Sbjct: 1168 VLNNFQILFNNYVSNRSDTFPS-GIIGRIPAYDPDVSDHLFYSFER-GNELQLLVVNQTS 1225
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTGGLSS 875
G ++ + LD + ++ S++ T GL S
Sbjct: 1226 GELR-LSRKLDNNRPLV--ASMLVTVTDGLHS 1254
Score = 68.5 bits (160), Expect = 2e-10
Identities = 53/176 (30%), Positives = 80/176 (45%), Gaps = 17/176 (9%)
Query: 220 AIDQDLGVGATLRYEL---ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
A D D G L Y L ++ +LFS+D +G + LD ++ L+V
Sbjct: 349 AQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDRESMER-----HYLRV 403
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A +P +A V + + D ND+ P FE Y ++ EN+ G+ +LQ+ ATD D
Sbjct: 404 TAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAP 463
Query: 337 ENGEFTYQLDDP-------KGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N Y+ P AF IDPRSG ++ + +DRE S + V A +
Sbjct: 464 PNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGR--VDREHMESYELVVEASD 517
Score = 58.8 bits (136), Expect = 1e-07
Identities = 65/236 (27%), Positives = 105/236 (44%), Gaps = 20/236 (8%)
Query: 160 HYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPE-PI 218
HY V+ D G L ++ ++ V D + F+ R + E +P +
Sbjct: 399 HYLRVTAQDHGSPRLSAT---TMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPILQL 455
Query: 219 HAIDQDLGVGATLRYELISGNDRKL-----FSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
A D D A LRY + + F +D +G + +D EH ++
Sbjct: 456 RATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVD--REH---MESYE 510
Query: 274 LQVQAS-QLNNP-LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMAT 331
L V+AS Q P ++A RV I +LD NDN P+F Y + E++ VL+V AT
Sbjct: 511 LVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTAT 570
Query: 332 DKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D+D+ NG Y + + +G F+ID +G + V LD EA +++ A++
Sbjct: 571 DRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQV--VAPLDFEAEREYALRIRAQD 624
Score = 57.2 bits (132), Expect = 4e-07
Identities = 96/408 (23%), Positives = 161/408 (39%), Gaps = 62/408 (15%)
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQP--SDTDL 1091
F + N H P F + Y V E + + +V A D D G+ L Y + + L
Sbjct: 315 FRRAANRH-PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSL 373
Query: 1092 P-FEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
F I P +G++ LDRE+ +++ L V A+D+G D ND+SP
Sbjct: 374 ELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHG-SPRLSATTMVAVTVADRNDHSPV 432
Query: 1151 FYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAP--------IGTTVAKVFAN 1202
F E +++ E N E I +AT + P +G A+ A
Sbjct: 433 F----EQAQYR-----ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAA 483
Query: 1203 DTDFIGNGNGLI------------LYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVE 1250
I +GLI Y L + Q S+T + +TV D E
Sbjct: 484 AAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLD-----E 538
Query: 1251 MSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFVI 1308
+ P F + Y ++ E+V ++ + T+ + N + Y I++ N R F I
Sbjct: 539 NDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNS---RGHFAI 595
Query: 1309 DPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVV 1368
D G + +V D E + Y + +RA Q R P++ + G+ +
Sbjct: 596 DSLTGEIQVVAPLDFEAEREYALRIRA--QDAGRP------PLSNNT--GLAS------I 639
Query: 1369 RIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQLKGAIGHHPTASR 1416
++ D+ND+ P F + P ++ AP G+ V+ ++ H +R
Sbjct: 640 QVVDINDHIPIFV--STPFQVSVLENAPLGHSVIHIQAVDADHGENAR 685
Score = 54.0 bits (124), Expect = 4e-06
Identities = 45/169 (26%), Positives = 85/169 (50%), Gaps = 14/169 (8%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I A+D D G A + Y+++ GN +LF +D +G L +LD +A +V+ VQ
Sbjct: 1089 ITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQE-----YVIVVQ 1143
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLP---EFEVDFYNI--SIVENLPNGFSVLQVMATD 332
A+ PL ++A V + L+D NDN P F++ F N + + P+G + ++ A D
Sbjct: 1144 ATSA--PL-VSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGI-IGRIPAYD 1199
Query: 333 KDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKV 381
D ++ ++++ + ++ SG L + + +R +S+ + V
Sbjct: 1200 PDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTV 1248
Score = 46.4 bits (105), Expect = 8e-04
Identities = 31/87 (35%), Positives = 44/87 (50%), Gaps = 7/87 (8%)
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGA-----FSIDPRS 358
P+F Y + EN G +VL+V+A D D GE G Y L + FSIDP+S
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
Query: 359 GWLTVRNQTVLDREAHSSLRMKVYAKE 385
G +R LDRE+ ++V A++
Sbjct: 383 G--LIRTAAALDRESMERHYLRVTAQD 407
Score = 44.0 bits (99), Expect = 0.004
Identities = 26/65 (40%), Positives = 40/65 (61%), Gaps = 4/65 (6%)
Query: 139 TIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQ 198
T+ + A DRDK N VHY+I+SGN GHFA++S + ++ LD++A ++E+
Sbjct: 562 TVVLRVTATDRDKD--ANGLVHYNIISGNSRGHFAIDSLTGEIQVVAP-LDFEA-EREYA 617
Query: 199 LVIMA 203
L I A
Sbjct: 618 LRIRA 622
Score = 33.9 bits (74), Expect = 4.5
Identities = 17/39 (43%), Positives = 24/39 (61%), Gaps = 1/39 (2%)
Query: 1441 ATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAAL 1479
A+D D+G NA I Y +L + P+F ID SG + + A L
Sbjct: 882 ASDDDVGENARITY-LLEDNLPQFRIDADSGAITLQAPL 919
>BC112084-1|AAI12085.1| 823|Homo sapiens protocadherin gamma
subfamily A, 1 protein.
Length = 823
Score = 117 bits (282), Expect = 3e-25
Identities = 128/473 (27%), Positives = 199/473 (42%), Gaps = 39/473 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E M VEV ++D NDN P F L EF M GT I D D+G N +
Sbjct: 111 EDKMKLFPVEVEIIDINDNTPQFQLEEL-EFKMNEITTPGTRISLPFGQDLDVGMNSLQS 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASD--QPANPSERRYS 551
Y L + ++ + V +SP+ E H L + ASD +P R
Sbjct: 170 YQLSSNPHFSLDVQQGADGPQHPEMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIY 229
Query: 552 LAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYD 609
+ VV + P P F A Y V NV +GT + + D E +V+Y
Sbjct: 230 IQVV-------DANDNP--PAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVTYS 280
Query: 610 LLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
H + V F ++ +G I+ + L MY E V Q+ A L + V+
Sbjct: 281 -FHNVDHRVAQIFRLDSYTGEISNKEPLDFEEYKMYSME-VQAQDGAGLMAKVKVLIKVL 338
Query: 668 DVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVT 727
DVND + + + V EN I + + NG F+ N
Sbjct: 339 DVNDNAPEV---TITSVTTAVPENFPPGTIIALISVHDQDSGDNGY-TTCFIPGNLPFKL 394
Query: 728 DDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVF 787
+ + + + T++ LDRE Y +T+ A ++G + + +++ + D NDN PVF
Sbjct: 395 EKL-VDNYYRLVTERTLDRELISGYNITITA-IDQGTPALSTETHISLLVTDINDNSPVF 452
Query: 788 EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEM---FDVDE 841
+Y +I EN+ G I ++A D D NA Y+L +G + ++
Sbjct: 453 HQDSYSAYIPENNPRGASIFS---VRAHDLDSNENAQITYSLIEDTIQGAPLSAYLSINS 509
Query: 842 NTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
+TGV+ + S D E+ +L ++ARD+G LSS L + + D+NDN PE
Sbjct: 510 DTGVL-YALRSFDYEQFRDMQLKVMARDSGDPPLSSNVSLSLFLLDQNDNAPE 561
Score = 81.8 bits (193), Expect = 2e-14
Identities = 81/284 (28%), Positives = 116/284 (40%), Gaps = 48/284 (16%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN+P+GT ++ +NA D D G NG++ Y F++ + V + F ++ G
Sbjct: 251 VPENVPLGTQLLMVNATDPDEGANGEVTYSFHNVDH-----------RVAQIFRLDSYTG 299
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ L E + + + A DG L + V + V DVND+ P T V E
Sbjct: 300 EISNKEPLDFEEYKMYSMEVQAQDGAGLMAKVKVLIKVLDVNDNAPEVTITSVTTAVPEN 359
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
++ + D D G N T FI P +LPF++ L L LDRE
Sbjct: 360 FPPGTIIALISVHDQDSGDNGYTTCFI-PG--NLPFKLEKLVDNYYRLVTERTLDRELIS 416
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFE 1174
Y +T+ A D G D+NDNSP F H ++
Sbjct: 417 GYNITITAIDQG-TPALSTETHISLLVTDINDNSPVF----------HQDS--------- 456
Query: 1175 SVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSL 1218
Y A I EN P G ++ V A+D D N N I YSL
Sbjct: 457 -------YSAYIPENNPRGASIFSVRAHDLD--SNENAQITYSL 491
Score = 79.8 bits (188), Expect = 7e-14
Identities = 107/476 (22%), Positives = 198/476 (41%), Gaps = 35/476 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
+ + + ++DANDN P F + Y ++ N +GT + V A DPD G NG V Y
Sbjct: 226 LRIYIQVVDANDNPPAFTQAQ-YHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNV 284
Query: 503 SNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
+ + F+++ TG +S E E +E Q + + + ++V
Sbjct: 285 DH-RVAQIFRLDSYTGEISNKEPLDFEEYKMYSMEVQAQDGAGLMAKVKVLIKVLDV--- 340
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAV 622
N P++ V N GT + I V+D + D Y +PF +
Sbjct: 341 -NDNAPEVTI---TSVTTAVPENFPPGTIIALISVHDQ-DSGDNGYTTCF-IPGNLPFKL 394
Query: 623 EER-SGVITVVDD--LSRYNRPMYDFEAVAL-QENANLSIVTNATVHVVDVNDERGVLLK 678
E+ +V + L R Y+ A+ Q LS T+ ++ V D+ND V +
Sbjct: 395 EKLVDNYYRLVTERTLDRELISGYNITITAIDQGTPALSTETHISLLVTDINDNSPVFHQ 454
Query: 679 GAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ----QDVTDDIAIAE 734
++S ++ EN+ A IF + N + + + ++ ++I
Sbjct: 455 DSYSA---YIPENNPRGA--SIFSVRAHDLDSNENAQITYSLIEDTIQGAPLSAYLSINS 509
Query: 735 D-GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP--VFEHAT 791
D G ++ + D E+ ++ V+A + G + +++++ D+NDN P ++
Sbjct: 510 DTGVLYALRSFDYEQFRDMQLKVMAR-DSGDPPLSSNVSLSLFLLDQNDNAPEILYPALP 568
Query: 792 YEGFI-MENSKIGTEI-KMDNIIKATDADEGTNALFMYTLFGEGKE-MFDVDENTGVVKF 848
+G +E + + E + + A D D G NA Y L + +F V +TG V+
Sbjct: 569 TDGSTGVELAPLSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRT 628
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDE-NDNKPEFNQIEENSK 901
LDR+ + L + +D G LS+ L + + D +D + +E ++K
Sbjct: 629 ARALLDRD-ALKQSLVVAVQDHGQPPLSATVTLTVAVADRISDILADLGSLEPSAK 683
Score = 74.9 bits (176), Expect = 2e-12
Identities = 52/168 (30%), Positives = 84/168 (50%), Gaps = 7/168 (4%)
Query: 222 DQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQL 281
D D+G+ + Y+L S L +G E L + +A ++ + AS
Sbjct: 159 DLDVGMNSLQSYQLSSNPHFSLDVQQGADGPQHPEMVLQSPLDREEEAVHHLI-LTASDG 217
Query: 282 NNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEF 341
P+++ R+ I+++D NDN P F Y+I++ EN+P G +L V ATD D+G NGE
Sbjct: 218 GEPVRSGTLRIYIQVVDANDNPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEV 277
Query: 342 TYQLD--DPKGA--FSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TY D + A F +D +G + N+ LD E + M+V A++
Sbjct: 278 TYSFHNVDHRVAQIFRLDSYTG--EISNKEPLDFEEYKMYSMEVQAQD 323
Score = 67.7 bits (158), Expect = 3e-10
Identities = 92/334 (27%), Positives = 139/334 (41%), Gaps = 44/334 (13%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVP-- 135
S L + + + D NDN P F YH+ V E P G + + +T
Sbjct: 223 SGTLRIYIQVVDANDNPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFH 282
Query: 136 ----RGLTIFKDIRAFDRDKPNTPNSDVH----YSIVSGNDDGHFALESSHKPVLLLRKV 187
R IF+ + ++ + N D YS+ DG + V +L KV
Sbjct: 283 NVDHRVAQIFR-LDSYTGEISNKEPLDFEEYKMYSMEVQAQDGAGLMAK----VKVLIKV 337
Query: 188 LDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGV-GATLRYELISGNDRK 242
LD + E V + S E P I A+ DQD G G T + I GN
Sbjct: 338 LDVNDNAPE---VTITSVTTAVPENFPPGTIIALISVHDQDSGDNGYTTCF--IPGN--L 390
Query: 243 LFSLDSVNGSLF-LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLND 301
F L+ + + + L E LD E + + + + A P + + + + + D+ND
Sbjct: 391 PFKLEKLVDNYYRLVTERTLDRE---LISGYNITITAIDQGTPALSTETHISLLVTDIND 447
Query: 302 NLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSG 359
N P F D Y+ I EN P G S+ V A D D EN + TY L D +GA P S
Sbjct: 448 NSPVFHQDSYSAYIPENNPRGASIFSVRAHDLDSNENAQITYSLIEDTIQGA----PLSA 503
Query: 360 WLTVRNQT-VL------DREAHSSLRMKVYAKET 386
+L++ + T VL D E +++KV A+++
Sbjct: 504 YLSINSDTGVLYALRSFDYEQFRDMQLKVMARDS 537
Score = 67.3 bits (157), Expect = 4e-10
Identities = 70/240 (29%), Positives = 102/240 (42%), Gaps = 19/240 (7%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
+I+V N A +V +PEN P GT I ++ D DSG NG +
Sbjct: 334 LIKVLDVNDNAPEVTITSVTTAVPENFPPGTIIALISVHDQDSGDNGYTTCFIPGNL--- 390
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFV 1035
P KL + L Y ++ ER + R L S + + I+A+D G L+ + + V
Sbjct: 391 PFKL--EKLVDNYYRLVTER----TLDRELI--SGYNITITAIDQGTPALSTETHISLLV 442
Query: 1036 KDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-----FIQPSDTD 1090
D+ND+ PVF + Y+ + E + V A D D +NA +TY IQ +
Sbjct: 443 TDINDNSPVFHQDSYSAYIPENNPRGASIFSVRAHDLDSNENAQITYSLIEDTIQGAPLS 502
Query: 1091 LPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
I+ TGVL D E L V+ARD+G D NDN+P+
Sbjct: 503 AYLSINSDTGVLYALRSFDYEQFRDMQLKVMARDSG-DPPLSSNVSLSLFLLDQNDNAPE 561
Score = 65.7 bits (153), Expect = 1e-09
Identities = 66/199 (33%), Positives = 93/199 (46%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P G +I + A DLDS N QI Y + I + LSA Y IN G
Sbjct: 461 IPENNPRGASIFSVRAHDLDSNENAQITYSLIEDT-IQGAPLSA-------YLSINSDTG 512
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK----KTWYN 1051
+ RS E + +L + A D G+ L+ N+S+ +F+ D ND+ P T +
Sbjct: 513 VLYALRSFDYEQFRDMQLKVMARDSGDPPLSSNVSLSLFLLDQNDNAPEILYPALPTDGS 572
Query: 1052 FNVEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG-VLSVNGE 1107
VE A + ++ KV A D D GQNA L+Y + + F + TG V +
Sbjct: 573 TGVELAPLSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAL 632
Query: 1108 LDRETEDKYILTVVARDNG 1126
LDR+ K L V +D+G
Sbjct: 633 LDRDAL-KQSLVVAVQDHG 650
Score = 62.5 bits (145), Expect = 1e-08
Identities = 59/210 (28%), Positives = 92/210 (43%), Gaps = 18/210 (8%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
GT I DLD G+N Y+ +S + +L+V++ +H +++
Sbjct: 149 GTRISLPFGQDLDVGMNSLQSYQLSSNPHF--------SLDVQQG-ADGPQHPEMVLQSP 199
Query: 1007 LPPESE--FRLNISALDGGNLNDNISVRVFVK--DVNDHFPVFKKTWYNFNVEEAQYTRR 1062
L E E L ++A DGG + ++R++++ D ND+ P F + Y+ NV E
Sbjct: 200 LDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHINVPENVPLGT 259
Query: 1063 VLGKVDATDADFGQNANLTYFIQPSDTDLP--FEISPLTGVLSVNGELDRETEDKYILTV 1120
L V+ATD D G N +TY D + F + TG +S LD E Y + V
Sbjct: 260 QLLMVNATDPDEGANGEVTYSFHNVDHRVAQIFRLDSYTGEISNKEPLDFEEYKMYSMEV 319
Query: 1121 VARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
A+D DVNDN+P+
Sbjct: 320 QAQDG---AGLMAKVKVLIKVLDVNDNAPE 346
Score = 62.1 bits (144), Expect = 1e-08
Identities = 50/173 (28%), Positives = 75/173 (43%), Gaps = 9/173 (5%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G++ T + +DRE+ M + FN V ++ V + I D NDN P F+ E
Sbjct: 82 GSLITARRIDREELCAQSMPCLVSFNILVEDKMKLFPVEVEIIDINDNTPQFQLEELEFK 141
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVK----FIGD 851
+ E + GT I + D D G N+L Y L DV + + +
Sbjct: 142 MNEITTPGTRISLP---FGQDLDVGMNSLQSYQLSSNPHFSLDVQQGADGPQHPEMVLQS 198
Query: 852 SLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKV 902
LDRE++ ++ L L A D G S + I + D NDN P F Q + + V
Sbjct: 199 PLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHINV 251
Score = 58.4 bits (135), Expect = 2e-07
Identities = 45/179 (25%), Positives = 84/179 (46%), Gaps = 11/179 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR--KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
++A D D G + Y + + R ++F LDS G + ++ LD + E+ + + ++
Sbjct: 264 VNATDPDEGANGEVTYSFHNVDHRVAQIFRLDSYTGEISNKEPLDFE-EYKM----YSME 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
VQA + A+ +V I++LD+NDN PE + ++ EN P G + + D+D
Sbjct: 319 VQAQDGAGLM--AKVKVLIKVLDVNDNAPEVTITSVTTAVPENFPPGTIIALISVHDQDS 376
Query: 336 GENGEFTYQLDDPKGAFSIDPR-SGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
G+NG +T F ++ + + + LDRE S + + A + + T
Sbjct: 377 GDNG-YTTCFIPGNLPFKLEKLVDNYYRLVTERTLDRELISGYNITITAIDQGTPALST 434
Score = 46.8 bits (106), Expect = 6e-04
Identities = 46/170 (27%), Positives = 77/170 (45%), Gaps = 20/170 (11%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR-----KLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A D D A + Y LI + S++S G L+ + D + ++Q
Sbjct: 474 VRAHDLDSNENAQITYSLIEDTIQGAPLSAYLSINSDTGVLYALRSFDYEQFRDMQ---- 529
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLP----NGFSV 325
L+V A +P ++ + + LLD NDN PE + + VE P G+ V
Sbjct: 530 -LKVMARDSGDPPLSSNVSLSLFLLDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLV 588
Query: 326 LQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREA 373
+V+A D+D G+N +Y+L G FS+ +G + + +LDR+A
Sbjct: 589 TKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTA-RALLDRDA 637
Score = 46.0 bits (104), Expect = 0.001
Identities = 35/125 (28%), Positives = 58/125 (46%), Gaps = 5/125 (4%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
++S LF+L+ +GSL + +D + L A + V + L K VE+
Sbjct: 66 IVSRGRMPLFALNPRSGSLITARRIDRE---ELCAQSMPCLVSFNILVED-KMKLFPVEV 121
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
E++D+NDN P+F+++ + E G + D D G N +YQL FS+
Sbjct: 122 EIIDINDNTPQFQLEELEFKMNEITTPGTRISLPFGQDLDVGMNSLQSYQLSS-NPHFSL 180
Query: 355 DPRSG 359
D + G
Sbjct: 181 DVQQG 185
Score = 43.6 bits (98), Expect = 0.006
Identities = 48/172 (27%), Positives = 77/172 (44%), Gaps = 27/172 (15%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN 1287
G P S T + + V D D + P F Y + + ENV +L+ +N T+ E
Sbjct: 218 GEPVRSGTLRIYIQVVDAND-----NPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEG 272
Query: 1288 FKMRY-YILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPH 1346
Y + D + + F +D G + ++E D +E E + YS E+
Sbjct: 273 ANGEVTYSFHNVDHRVAQIFRLDSYTGEI-----SNKEPLD-FE-----EYKMYSMEVQ- 320
Query: 1347 MIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFG 1398
A+D M K VKV++++ DVNDN+P+ T + + TA+P P G
Sbjct: 321 -----AQDGAGLMAK--VKVLIKVLDVNDNAPEVTITS--VTTAVPENFPPG 363
Score = 40.7 bits (91), Expect = 0.039
Identities = 42/170 (24%), Positives = 65/170 (38%), Gaps = 12/170 (7%)
Query: 992 FVINERHGHVIVARSLPPESEFRLNISALDGGNL--NDNIS---VRVFVKDVNDHFPVFK 1046
F +N R G +I AR + E ++ L N+ D + V V + D+ND+ P F+
Sbjct: 75 FALNPRSGSLITARRIDREELCAQSMPCLVSFNILVEDKMKLFPVEVEIIDINDNTPQFQ 134
Query: 1047 KTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGV 1101
F + E + D D G N+ +Y + S+ ++ P
Sbjct: 135 LEELEFKMNEITTPGTRISLPFGQDLDVGMNSLQSYQLS-SNPHFSLDVQQGADGPQHPE 193
Query: 1102 LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
+ + LDRE E + L + A D G D NDN P F
Sbjct: 194 MVLQSPLDREEEAVHHLILTASDGG-EPVRSGTLRIYIQVVDANDNPPAF 242
Score = 40.7 bits (91), Expect = 0.039
Identities = 38/131 (29%), Positives = 59/131 (45%), Gaps = 11/131 (8%)
Query: 436 DEQLMSFVNVEVTLLDANDNNP-VFVPSNLYEFS-----MKSNAKVGTVIGKVKAVDPDL 489
D L S V++ + LLD NDN P + P+ + S +A+ G ++ KV AVD D
Sbjct: 539 DPPLSSNVSLSLFLLDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLVTKVVAVDRDS 598
Query: 490 GQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSE 547
GQN + Y L + S + F + +TG V A + + + +L V D P
Sbjct: 599 GQNAWLSYRLLKASEPGL---FSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLS 655
Query: 548 RRYSLAVVTIE 558
+L V +
Sbjct: 656 ATVTLTVAVAD 666
Score = 33.5 bits (73), Expect = 6.0
Identities = 17/75 (22%), Positives = 37/75 (49%), Gaps = 3/75 (4%)
Query: 1330 EVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVT 1389
E+++++ + + H+I A D E + +++ +++ D NDN P FT +
Sbjct: 193 EMVLQSPLDREEEAVHHLIL-TASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHI-- 249
Query: 1390 AIPTTAPFGYQVMQL 1404
+P P G Q++ +
Sbjct: 250 NVPENVPLGTQLLMV 264
Score = 33.5 bits (73), Expect = 6.0
Identities = 14/51 (27%), Positives = 23/51 (45%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
+ I G +S +++ + D+NDN P+F Y + E P G F
Sbjct: 422 ITAIDQGTPALSTETHISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIF 472
>BC112082-1|AAI12083.1| 823|Homo sapiens protocadherin gamma
subfamily A, 1, isoform 2 precursor protein.
Length = 823
Score = 117 bits (282), Expect = 3e-25
Identities = 128/473 (27%), Positives = 199/473 (42%), Gaps = 39/473 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E M VEV ++D NDN P F L EF M GT I D D+G N +
Sbjct: 111 EDKMKLFPVEVEIIDINDNTPQFQLEEL-EFKMNEITTPGTRISLPFGQDLDVGMNSLQS 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASD--QPANPSERRYS 551
Y L + ++ + V +SP+ E H L + ASD +P R
Sbjct: 170 YQLSSNPHFSLDVQQGADGPQHPEMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIY 229
Query: 552 LAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYD 609
+ VV + P P F A Y V NV +GT + + D E +V+Y
Sbjct: 230 IQVV-------DANDNP--PAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVTYS 280
Query: 610 LLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
H + V F ++ +G I+ + L MY E V Q+ A L + V+
Sbjct: 281 -FHNVDHRVAQIFRLDSYTGEISNKEPLDFEEYKMYSME-VQAQDGAGLMAKVKVLIKVL 338
Query: 668 DVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVT 727
DVND + + + V EN I + + NG F+ N
Sbjct: 339 DVNDNAPEV---TITSVTTAVPENFPPGTIIALISVHDQDSGDNGY-TTCFIPGNLPFKL 394
Query: 728 DDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVF 787
+ + + + T++ LDRE Y +T+ A ++G + + +++ + D NDN PVF
Sbjct: 395 EKL-VDNYYRLVTERTLDRELISGYNITITA-IDQGTPALSTETHISLLVTDINDNSPVF 452
Query: 788 EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEM---FDVDE 841
+Y +I EN+ G I ++A D D NA Y+L +G + ++
Sbjct: 453 HQDSYSAYIPENNPRGASIFS---VRAHDLDSNENAQITYSLIEDTIQGAPLSAYLSINS 509
Query: 842 NTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
+TGV+ + S D E+ +L ++ARD+G LSS L + + D+NDN PE
Sbjct: 510 DTGVL-YALRSFDYEQFRDMQLKVMARDSGDPPLSSNVSLSLFLLDQNDNAPE 561
Score = 81.8 bits (193), Expect = 2e-14
Identities = 81/284 (28%), Positives = 116/284 (40%), Gaps = 48/284 (16%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN+P+GT ++ +NA D D G NG++ Y F++ + V + F ++ G
Sbjct: 251 VPENVPLGTQLLMVNATDPDEGANGEVTYSFHNVDH-----------RVAQIFRLDSYTG 299
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ L E + + + A DG L + V + V DVND+ P T V E
Sbjct: 300 EISNKEPLDFEEYKMYSMEVQAQDGAGLMAKVKVLIKVLDVNDNAPEVTITSVTTAVPEN 359
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
++ + D D G N T FI P +LPF++ L L LDRE
Sbjct: 360 FPPGTIIALISVHDQDSGDNGYTTCFI-PG--NLPFKLEKLVDNYYRLVTERTLDRELIS 416
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFE 1174
Y +T+ A D G D+NDNSP F H ++
Sbjct: 417 GYNITITAIDQG-TPALSTETHISLLVTDINDNSPVF----------HQDS--------- 456
Query: 1175 SVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSL 1218
Y A I EN P G ++ V A+D D N N I YSL
Sbjct: 457 -------YSAYIPENNPRGASIFSVRAHDLD--SNENAQITYSL 491
Score = 79.8 bits (188), Expect = 7e-14
Identities = 107/476 (22%), Positives = 198/476 (41%), Gaps = 35/476 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
+ + + ++DANDN P F + Y ++ N +GT + V A DPD G NG V Y
Sbjct: 226 LRIYIQVVDANDNPPAFTQAQ-YHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNV 284
Query: 503 SNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
+ + F+++ TG +S E E +E Q + + + ++V
Sbjct: 285 DH-RVAQIFRLDSYTGEISNKEPLDFEEYKMYSMEVQAQDGAGLMAKVKVLIKVLDV--- 340
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAV 622
N P++ V N GT + I V+D + D Y +PF +
Sbjct: 341 -NDNAPEVTI---TSVTTAVPENFPPGTIIALISVHDQ-DSGDNGYTTCF-IPGNLPFKL 394
Query: 623 EER-SGVITVVDD--LSRYNRPMYDFEAVAL-QENANLSIVTNATVHVVDVNDERGVLLK 678
E+ +V + L R Y+ A+ Q LS T+ ++ V D+ND V +
Sbjct: 395 EKLVDNYYRLVTERTLDRELISGYNITITAIDQGTPALSTETHISLLVTDINDNSPVFHQ 454
Query: 679 GAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ----QDVTDDIAIAE 734
++S ++ EN+ A IF + N + + + ++ ++I
Sbjct: 455 DSYSA---YIPENNPRGA--SIFSVRAHDLDSNENAQITYSLIEDTIQGAPLSAYLSINS 509
Query: 735 D-GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP--VFEHAT 791
D G ++ + D E+ ++ V+A + G + +++++ D+NDN P ++
Sbjct: 510 DTGVLYALRSFDYEQFRDMQLKVMAR-DSGDPPLSSNVSLSLFLLDQNDNAPEILYPALP 568
Query: 792 YEGFI-MENSKIGTEI-KMDNIIKATDADEGTNALFMYTLFGEGKE-MFDVDENTGVVKF 848
+G +E + + E + + A D D G NA Y L + +F V +TG V+
Sbjct: 569 TDGSTGVELAPLSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRT 628
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDE-NDNKPEFNQIEENSK 901
LDR+ + L + +D G LS+ L + + D +D + +E ++K
Sbjct: 629 ARALLDRD-ALKQSLVVAVQDHGQPPLSATVTLTVAVADRISDILADLGSLEPSAK 683
Score = 74.9 bits (176), Expect = 2e-12
Identities = 52/168 (30%), Positives = 84/168 (50%), Gaps = 7/168 (4%)
Query: 222 DQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQL 281
D D+G+ + Y+L S L +G E L + +A ++ + AS
Sbjct: 159 DLDVGMNSLQSYQLSSNPHFSLDVQQGADGPQHPEMVLQSPLDREEEAVHHLI-LTASDG 217
Query: 282 NNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEF 341
P+++ R+ I+++D NDN P F Y+I++ EN+P G +L V ATD D+G NGE
Sbjct: 218 GEPVRSGTLRIYIQVVDANDNPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEV 277
Query: 342 TYQLD--DPKGA--FSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TY D + A F +D +G + N+ LD E + M+V A++
Sbjct: 278 TYSFHNVDHRVAQIFRLDSYTG--EISNKEPLDFEEYKMYSMEVQAQD 323
Score = 67.7 bits (158), Expect = 3e-10
Identities = 92/334 (27%), Positives = 139/334 (41%), Gaps = 44/334 (13%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVP-- 135
S L + + + D NDN P F YH+ V E P G + + +T
Sbjct: 223 SGTLRIYIQVVDANDNPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFH 282
Query: 136 ----RGLTIFKDIRAFDRDKPNTPNSDVH----YSIVSGNDDGHFALESSHKPVLLLRKV 187
R IF+ + ++ + N D YS+ DG + V +L KV
Sbjct: 283 NVDHRVAQIFR-LDSYTGEISNKEPLDFEEYKMYSMEVQAQDGAGLMAK----VKVLIKV 337
Query: 188 LDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGV-GATLRYELISGNDRK 242
LD + E V + S E P I A+ DQD G G T + I GN
Sbjct: 338 LDVNDNAPE---VTITSVTTAVPENFPPGTIIALISVHDQDSGDNGYTTCF--IPGN--L 390
Query: 243 LFSLDSVNGSLF-LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLND 301
F L+ + + + L E LD E + + + + A P + + + + + D+ND
Sbjct: 391 PFKLEKLVDNYYRLVTERTLDRE---LISGYNITITAIDQGTPALSTETHISLLVTDIND 447
Query: 302 NLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSG 359
N P F D Y+ I EN P G S+ V A D D EN + TY L D +GA P S
Sbjct: 448 NSPVFHQDSYSAYIPENNPRGASIFSVRAHDLDSNENAQITYSLIEDTIQGA----PLSA 503
Query: 360 WLTVRNQT-VL------DREAHSSLRMKVYAKET 386
+L++ + T VL D E +++KV A+++
Sbjct: 504 YLSINSDTGVLYALRSFDYEQFRDMQLKVMARDS 537
Score = 67.3 bits (157), Expect = 4e-10
Identities = 70/240 (29%), Positives = 102/240 (42%), Gaps = 19/240 (7%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
+I+V N A +V +PEN P GT I ++ D DSG NG +
Sbjct: 334 LIKVLDVNDNAPEVTITSVTTAVPENFPPGTIIALISVHDQDSGDNGYTTCFIPGNL--- 390
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFV 1035
P KL + L Y ++ ER + R L S + + I+A+D G L+ + + V
Sbjct: 391 PFKL--EKLVDNYYRLVTER----TLDRELI--SGYNITITAIDQGTPALSTETHISLLV 442
Query: 1036 KDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-----FIQPSDTD 1090
D+ND+ PVF + Y+ + E + V A D D +NA +TY IQ +
Sbjct: 443 TDINDNSPVFHQDSYSAYIPENNPRGASIFSVRAHDLDSNENAQITYSLIEDTIQGAPLS 502
Query: 1091 LPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
I+ TGVL D E L V+ARD+G D NDN+P+
Sbjct: 503 AYLSINSDTGVLYALRSFDYEQFRDMQLKVMARDSG-DPPLSSNVSLSLFLLDQNDNAPE 561
Score = 65.7 bits (153), Expect = 1e-09
Identities = 66/199 (33%), Positives = 93/199 (46%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P G +I + A DLDS N QI Y + I + LSA Y IN G
Sbjct: 461 IPENNPRGASIFSVRAHDLDSNENAQITYSLIEDT-IQGAPLSA-------YLSINSDTG 512
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK----KTWYN 1051
+ RS E + +L + A D G+ L+ N+S+ +F+ D ND+ P T +
Sbjct: 513 VLYALRSFDYEQFRDMQLKVMARDSGDPPLSSNVSLSLFLLDQNDNAPEILYPALPTDGS 572
Query: 1052 FNVEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG-VLSVNGE 1107
VE A + ++ KV A D D GQNA L+Y + + F + TG V +
Sbjct: 573 TGVELAPLSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAL 632
Query: 1108 LDRETEDKYILTVVARDNG 1126
LDR+ K L V +D+G
Sbjct: 633 LDRDAL-KQSLVVAVQDHG 650
Score = 62.5 bits (145), Expect = 1e-08
Identities = 59/210 (28%), Positives = 92/210 (43%), Gaps = 18/210 (8%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
GT I DLD G+N Y+ +S + +L+V++ +H +++
Sbjct: 149 GTRISLPFGQDLDVGMNSLQSYQLSSNPHF--------SLDVQQG-ADGPQHPEMVLQSP 199
Query: 1007 LPPESE--FRLNISALDGGNLNDNISVRVFVK--DVNDHFPVFKKTWYNFNVEEAQYTRR 1062
L E E L ++A DGG + ++R++++ D ND+ P F + Y+ NV E
Sbjct: 200 LDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHINVPENVPLGT 259
Query: 1063 VLGKVDATDADFGQNANLTYFIQPSDTDLP--FEISPLTGVLSVNGELDRETEDKYILTV 1120
L V+ATD D G N +TY D + F + TG +S LD E Y + V
Sbjct: 260 QLLMVNATDPDEGANGEVTYSFHNVDHRVAQIFRLDSYTGEISNKEPLDFEEYKMYSMEV 319
Query: 1121 VARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
A+D DVNDN+P+
Sbjct: 320 QAQDG---AGLMAKVKVLIKVLDVNDNAPE 346
Score = 62.1 bits (144), Expect = 1e-08
Identities = 50/173 (28%), Positives = 75/173 (43%), Gaps = 9/173 (5%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G++ T + +DRE+ M + FN V ++ V + I D NDN P F+ E
Sbjct: 82 GSLITARRIDREELCAQSMPCLVSFNILVEDKMKLFPVEVEIIDINDNTPQFQLEELEFK 141
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVK----FIGD 851
+ E + GT I + D D G N+L Y L DV + + +
Sbjct: 142 MNEITTPGTRISLP---FGQDLDVGMNSLQSYQLSSNPHFSLDVQQGADGPQHPEMVLQS 198
Query: 852 SLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKV 902
LDRE++ ++ L L A D G S + I + D NDN P F Q + + V
Sbjct: 199 PLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHINV 251
Score = 58.4 bits (135), Expect = 2e-07
Identities = 45/179 (25%), Positives = 84/179 (46%), Gaps = 11/179 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR--KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
++A D D G + Y + + R ++F LDS G + ++ LD + E+ + + ++
Sbjct: 264 VNATDPDEGANGEVTYSFHNVDHRVAQIFRLDSYTGEISNKEPLDFE-EYKM----YSME 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
VQA + A+ +V I++LD+NDN PE + ++ EN P G + + D+D
Sbjct: 319 VQAQDGAGLM--AKVKVLIKVLDVNDNAPEVTITSVTTAVPENFPPGTIIALISVHDQDS 376
Query: 336 GENGEFTYQLDDPKGAFSIDPR-SGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
G+NG +T F ++ + + + LDRE S + + A + + T
Sbjct: 377 GDNG-YTTCFIPGNLPFKLEKLVDNYYRLVTERTLDRELISGYNITITAIDQGTPALST 434
Score = 46.8 bits (106), Expect = 6e-04
Identities = 46/170 (27%), Positives = 77/170 (45%), Gaps = 20/170 (11%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR-----KLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A D D A + Y LI + S++S G L+ + D + ++Q
Sbjct: 474 VRAHDLDSNENAQITYSLIEDTIQGAPLSAYLSINSDTGVLYALRSFDYEQFRDMQ---- 529
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLP----NGFSV 325
L+V A +P ++ + + LLD NDN PE + + VE P G+ V
Sbjct: 530 -LKVMARDSGDPPLSSNVSLSLFLLDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLV 588
Query: 326 LQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREA 373
+V+A D+D G+N +Y+L G FS+ +G + + +LDR+A
Sbjct: 589 TKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTA-RALLDRDA 637
Score = 46.0 bits (104), Expect = 0.001
Identities = 35/125 (28%), Positives = 58/125 (46%), Gaps = 5/125 (4%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
++S LF+L+ +GSL + +D + L A + V + L K VE+
Sbjct: 66 IVSRGRMPLFALNPRSGSLITARRIDRE---ELCAQSMPCLVSFNILVED-KMKLFPVEV 121
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
E++D+NDN P+F+++ + E G + D D G N +YQL FS+
Sbjct: 122 EIIDINDNTPQFQLEELEFKMNEITTPGTRISLPFGQDLDVGMNSLQSYQLSS-NPHFSL 180
Query: 355 DPRSG 359
D + G
Sbjct: 181 DVQQG 185
Score = 43.6 bits (98), Expect = 0.006
Identities = 48/172 (27%), Positives = 77/172 (44%), Gaps = 27/172 (15%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN 1287
G P S T + + V D D + P F Y + + ENV +L+ +N T+ E
Sbjct: 218 GEPVRSGTLRIYIQVVDAND-----NPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEG 272
Query: 1288 FKMRY-YILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPH 1346
Y + D + + F +D G + ++E D +E E + YS E+
Sbjct: 273 ANGEVTYSFHNVDHRVAQIFRLDSYTGEI-----SNKEPLD-FE-----EYKMYSMEVQ- 320
Query: 1347 MIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFG 1398
A+D M K VKV++++ DVNDN+P+ T + + TA+P P G
Sbjct: 321 -----AQDGAGLMAK--VKVLIKVLDVNDNAPEVTITS--VTTAVPENFPPG 363
Score = 40.7 bits (91), Expect = 0.039
Identities = 42/170 (24%), Positives = 65/170 (38%), Gaps = 12/170 (7%)
Query: 992 FVINERHGHVIVARSLPPESEFRLNISALDGGNL--NDNIS---VRVFVKDVNDHFPVFK 1046
F +N R G +I AR + E ++ L N+ D + V V + D+ND+ P F+
Sbjct: 75 FALNPRSGSLITARRIDREELCAQSMPCLVSFNILVEDKMKLFPVEVEIIDINDNTPQFQ 134
Query: 1047 KTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGV 1101
F + E + D D G N+ +Y + S+ ++ P
Sbjct: 135 LEELEFKMNEITTPGTRISLPFGQDLDVGMNSLQSYQLS-SNPHFSLDVQQGADGPQHPE 193
Query: 1102 LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
+ + LDRE E + L + A D G D NDN P F
Sbjct: 194 MVLQSPLDREEEAVHHLILTASDGG-EPVRSGTLRIYIQVVDANDNPPAF 242
Score = 40.7 bits (91), Expect = 0.039
Identities = 38/131 (29%), Positives = 59/131 (45%), Gaps = 11/131 (8%)
Query: 436 DEQLMSFVNVEVTLLDANDNNP-VFVPSNLYEFS-----MKSNAKVGTVIGKVKAVDPDL 489
D L S V++ + LLD NDN P + P+ + S +A+ G ++ KV AVD D
Sbjct: 539 DPPLSSNVSLSLFLLDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLVTKVVAVDRDS 598
Query: 490 GQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSE 547
GQN + Y L + S + F + +TG V A + + + +L V D P
Sbjct: 599 GQNAWLSYRLLKASEPGL---FSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLS 655
Query: 548 RRYSLAVVTIE 558
+L V +
Sbjct: 656 ATVTLTVAVAD 666
Score = 33.5 bits (73), Expect = 6.0
Identities = 17/75 (22%), Positives = 37/75 (49%), Gaps = 3/75 (4%)
Query: 1330 EVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVT 1389
E+++++ + + H+I A D E + +++ +++ D NDN P FT +
Sbjct: 193 EMVLQSPLDREEEAVHHLIL-TASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHI-- 249
Query: 1390 AIPTTAPFGYQVMQL 1404
+P P G Q++ +
Sbjct: 250 NVPENVPLGTQLLMV 264
Score = 33.5 bits (73), Expect = 6.0
Identities = 14/51 (27%), Positives = 23/51 (45%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
+ I G +S +++ + D+NDN P+F Y + E P G F
Sbjct: 422 ITAIDQGTPALSTETHISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIF 472
>AB053446-1|BAB61903.2| 3434|Homo sapiens KIAA1773 protein protein.
Length = 3434
Score = 117 bits (282), Expect = 3e-25
Identities = 126/451 (27%), Positives = 199/451 (44%), Gaps = 33/451 (7%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V L D NDN+P F P+ + N GT I ++A+DPD G N V + L
Sbjct: 1016 VRVLLDDVNDNSPAF-PAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGG 1074
Query: 505 LTITSPFKINPNTGTVSVAE--SPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F ++P TG V + P H L +EA D + P + L VV +V G
Sbjct: 1075 ----GAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDV--G 1128
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGV--PF 620
T+G P F Y + S GT V Q++ A + ++Y L EG PF
Sbjct: 1129 TRGLAPR---FNSPTYRVDLPSGTTAGTQVLQVQAQ-APDGGPITYHLA---AEGASSPF 1181
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTN-ATVHVVDVN-DERGVLL 677
+E +SG + V L R + +Y + +A+ A L T ATV V +N +E L
Sbjct: 1182 GLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRL 1241
Query: 678 KGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AED 735
+ P V EN G ++G++F T+ S G + + + + + I +
Sbjct: 1242 --SEDPTFLAVAENQPPGTSVGRVFATDRDS---GPNGRLTYSLQQLSEDSKAFRIHPQT 1296
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G + T + LDRE++ Y++ V + + G + V + + D NDN P F A+
Sbjct: 1297 GEVTTLQTLDREQQSSYQLLVQVQ-DGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAG 1355
Query: 796 IMENSKIGTEIKMDNII---KATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDS 852
++ + ++ +A D DEG N +YTL G G E+F + ++G +
Sbjct: 1356 GGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGEL-LTAAP 1414
Query: 853 LDREKKIMYKLSLVARDTGGLSSEAELIIMI 883
L R ++ Y L+L A D G A L +++
Sbjct: 1415 LIRAERPHYVLTLSAHDQGSPPRSASLQLLV 1445
Score = 115 bits (277), Expect = 1e-24
Identities = 131/463 (28%), Positives = 199/463 (42%), Gaps = 32/463 (6%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
++VTLLD ND+ P F S + +S A G+ + +V A D D G NG V Y++ R +
Sbjct: 377 LDVTLLDINDHAPAFNQSRYHAVVSESLAP-GSPVLQVFASDADAGVNGAVTYEINRRQS 435
Query: 505 LTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRG 562
PF I+ +TG + + E R H L V+A D A+P A VT+ V R
Sbjct: 436 -EGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHP---ELGSAFVTVHV-RD 490
Query: 563 TKGNKPDIP-DFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFA 621
N+P + F+ A V G V +I V+D + + ++ EG FA
Sbjct: 491 ANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEG-HFA 549
Query: 622 VEERSGVI---TVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLL 677
+ + VI V L R R Y+ A + L +HV DVND
Sbjct: 550 LSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFD 609
Query: 678 KGAHSPIIFHVKENSAGAAIGQIFHTNMSS-IYGNGT-GNVRFLIANQQDVTDDIAIAED 735
+ + P E A+ F +++ GT G V + +A
Sbjct: 610 RQLYRP------EPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTS 663
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I T LD E ++ V+A + G+ A V++ ++D NDN P F+ Y
Sbjct: 664 GIITTAASLDYELEPQPQLIVVAT-DGGLPPLASSATVSVALQDVNDNEPQFQRTFYNAS 722
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYT----LFGEGKEMFDVDENTGVVKFIGD 851
+ E ++ GT + ATDAD G L Y+ L G F +D ++G V
Sbjct: 723 LPEGTQPGTCFLQ---VTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDV-CTTR 778
Query: 852 SLDREK-KIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEF 893
+LDR++ + ++ A D GGL S + + + DENDN P+F
Sbjct: 779 TLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNPPQF 821
Score = 105 bits (253), Expect = 9e-22
Identities = 124/465 (26%), Positives = 196/465 (42%), Gaps = 34/465 (7%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGT---VIGKVKAVDPDLGQNGMV 495
L + V+V +T+ D ND+ P F S L + T + ++A D D G N +
Sbjct: 2076 LSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASI 2135
Query: 496 LYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRH--ALFVEASDQPANPSERRYSLA 553
LY L T T ++ TG + VA SP+ G LF+ A+D P+ +
Sbjct: 2136 LYRLAGTPPPGTT----VDSYTGEIRVARSPVALGPRDRVLFIVATDL-GRPARSATGVI 2190
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND-VSYDLLH 612
+V G +G P F A E + N GT + R A N ++Y +L
Sbjct: 2191 IV------GLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTNGPITYSILS 2244
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDE 672
G E+G F+++ +G ITV V E+ T T+ + D ND
Sbjct: 2245 GNEKGT-FSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDN 2303
Query: 673 RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI 732
L+ + + F + + Q+ ++ G+G G + + +A Q +
Sbjct: 2304 APRFLRPHY--VAFLPESRPLEGPLLQVEADDLDQ--GSG-GQISYSLAASQPARGLFHV 2358
Query: 733 -AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
GTI T LDRE R+ ++A ++G + G +T+ + D NDN P
Sbjct: 2359 DPTTGTITTTAILDREIWAETRLVLMAT-DRGSPALVGSATLTVMVIDTNDNRPTIPQP- 2416
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG-KEMFDVDENTGVVKFIG 850
+E + E++ +G+EI + D D G + Y L G ++ F V G V G
Sbjct: 2417 WELRVSEDALLGSEIAQ---VTGNDVDSGP--VLWYVLSPSGPQDPFSVGRYGGRVSLTG 2471
Query: 851 DSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQ 895
LD E+ Y+L L+A D G A L +++ D NDN P F+Q
Sbjct: 2472 P-LDFEQCDRYQLQLLAHD-GPHEGRANLTVLVEDVNDNAPAFSQ 2514
Score = 101 bits (241), Expect = 3e-20
Identities = 120/460 (26%), Positives = 198/460 (43%), Gaps = 33/460 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPD-LGQNGMVLYDLQR 501
+ V+V + D N++ P F L ++ N + G + +A D D G N V Y L R
Sbjct: 1556 LRVQVQVQDENEHAPAFARDPL-ALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLR 1614
Query: 502 TSNLTITSPFKINPNTGTVSVAESPILEGRHALF--VEASDQPANPSERRYSLAVVTIEV 559
+++ TG +S E AL VEA+D+PAN S RR + + V
Sbjct: 1615 QE--PPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFV 1672
Query: 560 TRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQI--RVNDAFEQNDVSYDLLHGYEEG 617
T ++ D +P + + G + + R D E VSY L G +
Sbjct: 1673 T-----DENDNAPVFASPSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDG- 1726
Query: 618 VPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNA-TVHVVDVNDERGVL 676
F + +G ++VV L R R + VA + T TV V DVNDE
Sbjct: 1727 -HFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTF 1785
Query: 677 LKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDG 736
+ +S ++ + N G ++ + T+ G V + + + + D + G
Sbjct: 1786 QQQEYSVLL--RENNPPGTSLLTLRATDPDV---GANGQVTYGGVSSESFSLD---PDTG 1837
Query: 737 TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFI 796
+ T + LDRE+++ +TV A+ ++G V + +EDEND+ P F A +
Sbjct: 1838 VLTTLRALDREEQEEINLTVYAQ-DRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEV 1896
Query: 797 MENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTGVVKFIGDSLDR 855
E G + + +++A+D D G N Y + G+ F +D +G + LDR
Sbjct: 1897 PE----GQDPQTLTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTM-RPLDR 1951
Query: 856 EKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEF 893
E + ++L + ARD G LS+ L + + D ND+ P F
Sbjct: 1952 EVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAF 1991
Score = 99 bits (238), Expect = 6e-20
Identities = 125/499 (25%), Positives = 206/499 (41%), Gaps = 39/499 (7%)
Query: 445 VEVTLLDANDNNPVFVPSNL-----YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
V V +LD NDN+P F+ ++ + GT++ ++A DPD G+NG +LY L
Sbjct: 1333 VHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTL 1392
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTI 557
+ F ++P++G + A I R + L + A DQ + P L V +
Sbjct: 1393 TGPGS----ELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVL 1448
Query: 558 EVTRGTKGNKPDIPDFMGA---PYEFWVGSNVGI--GTSVGQIRVNDAFEQNDVSYDLLH 612
R + PD+ + A P V + G+ G+ +G + + ++Y L+
Sbjct: 1449 PSARLAEP-PPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVG 1507
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSI-VTNATVHVVDVND 671
G + FA++ SG + + L P + V + + V V D N+
Sbjct: 1508 GADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENE 1567
Query: 672 ERGVLLKGAHSPIIFHVKEN-SAGAAIGQIFHTNMSSIYGNG-TGNVRFLIANQQDVTDD 729
A P+ + EN GAA+ + S G G +VR+ + Q+
Sbjct: 1568 HAPAF---ARDPLALALPENPEPGAAL---YTFRASDADGPGPNSDVRYRLLRQEPPVPA 1621
Query: 730 IAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVT--IYIEDENDNPPV 786
+ + A G + + LDRE + V A S +V+ +++ DENDN PV
Sbjct: 1622 LRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPV 1681
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVV 846
F + + E+ G + A D D G A Y L G F + +TG +
Sbjct: 1682 FASPSRVR-LPEDQPPGPAALH---VVARDPDLGEAARVSYRLASGGDGHFRLHSSTGAL 1737
Query: 847 KFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRI 904
+ LDRE++ + L++VA D G S+ L + + D ND P F Q E + +
Sbjct: 1738 SVVRP-LDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSV---L 1793
Query: 905 HRETKLNGTAGFTIIEVKP 923
RE GT+ T+ P
Sbjct: 1794 LRENNPPGTSLLTLRATDP 1812
Score = 96.7 bits (230), Expect = 6e-19
Identities = 120/467 (25%), Positives = 195/467 (41%), Gaps = 34/467 (7%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L S V V L D NDN P F Y S+ + GT +V A D D G G++ Y
Sbjct: 694 LASSATVSVALQDVNDNEPQF-QRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYS 752
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIE 558
L + + PF+I+ ++G V + + + F D + ++V ++
Sbjct: 753 LGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSF----DFTVTAVDGGGLKSMVYVK 808
Query: 559 VTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGYEE 616
V + + P P F Y + + GT+V ++R +D + +SY +L G
Sbjct: 809 VFLSDENDNP--PQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSP 866
Query: 617 GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVL 676
+ F ++E+SG++TV L+R + E + ++ L +A VD++ G
Sbjct: 867 PL-FTLDEQSGLLTVAWPLARRANSVVQLE-IGAEDGGGLQAEPSAR---VDISIVPGTP 921
Query: 677 LKGAHSPI--IFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI- 732
+ +F V E+ A G ++G + N T L + D ++
Sbjct: 922 TPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVT-----LSLSGGDPRGLFSLD 976
Query: 733 AEDGTIFTQKPLDRE-KRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
A G + T +PLDRE V + V A GV + +V + ++D NDN P F
Sbjct: 977 AVSGLLQTLRPLDRELLGPVLELEVRA--GSGVPPAFAVARVRVLLDDVNDNSPAFPAPE 1034
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD 851
+ N+ GT I ++A D D G N+ +TL G F VD TG V+ +
Sbjct: 1035 DTVLLPPNTAPGTPI---YTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLM-R 1090
Query: 852 SLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDN--KPEFN 894
L ++L L ARD G +S L +++ D P FN
Sbjct: 1091 PLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFN 1137
Score = 93.9 bits (223), Expect = 4e-18
Identities = 62/173 (35%), Positives = 90/173 (52%), Gaps = 11/173 (6%)
Query: 215 PEPIHAI--DQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
P +H + D DLG A + Y L SG D F L S G+L + + LD + Q
Sbjct: 1698 PAALHVVARDPDLGEAARVSYRLASGGDGH-FRLHSSTGALSVVRPLDRE-----QRAEH 1751
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
VL V AS +P ++A + + + D+ND P F+ Y++ + EN P G S+L + ATD
Sbjct: 1752 VLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATD 1811
Query: 333 KDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D G NG+ TY +FS+DP +G LT LDRE + + VYA++
Sbjct: 1812 PDVGANGQVTYG-GVSSESFSLDPDTGVLTTLR--ALDREEQEEINLTVYAQD 1861
Score = 92.3 bits (219), Expect = 1e-17
Identities = 116/464 (25%), Positives = 188/464 (40%), Gaps = 50/464 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PE+ P G + + A D D G ++ Y S D +F ++ G
Sbjct: 1690 LPEDQPPGPAALHVVARDPDLGEAARVSYRLAS---------GGDG-----HFRLHSSTG 1735
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGNLNDNIS--VRVFVKDVNDHFPVFKKTWYNFNVE 1055
+ V R L E +E L + A D G+ + + + V V DVND P F++ Y+ +
Sbjct: 1736 ALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLR 1795
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E L + ATD D G N +TY S++ F + P TGVL+ LDRE +++
Sbjct: 1796 ENNPPGTSLLTLRATDPDVGANGQVTYGGVSSES---FSLDPDTGVLTTLRALDREEQEE 1852
Query: 1116 YILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF---YAFDELLEWKHPEADELSNHN 1172
LTV A+D G D ND++P F + E+ E + P+ + +
Sbjct: 1853 INLTVYAQDRG-SPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTMLRAS 1911
Query: 1173 FESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSL 1232
V + I + P G V + + + + + + + R ++ G P+L
Sbjct: 1912 DPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPAL 1971
Query: 1233 SSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENFKMRY 1292
S+T +L VTV D D P F Y +E+ E+V P + L L H +
Sbjct: 1972 SATLLLTVTVLDANDHA-----PAFPVPAYSVEVPEDV--PAGTLLLQLQAHDPDAGANG 2024
Query: 1293 YILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVA 1352
++ F+++P +G L + DRE +Y V A
Sbjct: 2025 HVTYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSA----------------V 2068
Query: 1353 EDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAP 1396
+ G V V + ++DVND++P F PL +P P
Sbjct: 2069 DGAAAGPLSTTVSVTITVRDVNDHAPTFPTS--PLRLRLPRPGP 2110
Score = 90.6 bits (215), Expect = 4e-17
Identities = 56/167 (33%), Positives = 82/167 (49%), Gaps = 8/167 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D+G L+Y ++ G+ F LD +G + LD + E F L+++
Sbjct: 1908 LRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEP-----AFQLRIE 1962
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A P +A + + +LD ND+ P F V Y++ + E++P G +LQ+ A D D G
Sbjct: 1963 ARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGA 2022
Query: 338 NGEFTYQLD-DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
NG TY L GAF ++P SG L R LDRE S V A
Sbjct: 2023 NGHVTYYLGAGTAGAFLLEPSSGEL--RTAAALDREQCPSYTFSVSA 2067
Score = 89.8 bits (213), Expect = 6e-17
Identities = 119/475 (25%), Positives = 208/475 (43%), Gaps = 45/475 (9%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L+ + V ++D NDN P +P +E + +A +G+ I +V D D +G VL+
Sbjct: 2393 LVGSATLTVMVIDTNDNRPT-IPQP-WELRVSEDALLGSEIAQVTGNDVD---SGPVLWY 2447
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVT 556
+ S PF + G VS+ E R+ L + A D P E R +L V+
Sbjct: 2448 VLSPSGPQ--DPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD---GPHEGRANLTVLV 2502
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLHGY 614
+V + P F + Y+ + + G+++ + D + +SY L
Sbjct: 2503 EDVN-------DNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPA 2555
Query: 615 EEGVPFAVEERSGVI-TVVDDLSRYNRPMYDFEAVA-LQENANLSIVTNATVHVV--DVN 670
+ F+V+ +G + T+V ++ + + V +++ ATVHV D N
Sbjct: 2556 DG---FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQN 2612
Query: 671 DER-GVLLKGAHSPIIFHVKENS------AGAAIGQIFHTNMS-SIYGNGTGNVRFLIAN 722
D L + + S A A G H + SI G V L
Sbjct: 2613 DHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPR 2672
Query: 723 QQDVTDDIAIAED--GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDE 780
+ + G + +PLD E Y +TV A ++G + + VT+ + D
Sbjct: 2673 LAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAA-DRGQPPQSSVVPVTVTVLDV 2731
Query: 781 NDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL-FGEGKEMFDV 839
NDNPPVF A+Y + E++ +G E+ ++A+DAD G + L +T+ G+ +F++
Sbjct: 2732 NDNPPVFTRASYRVTVPEDTPVGAELLH---VEASDADPGPHGLVRFTVSSGDPSGLFEL 2788
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLS-SEAELIIMIGDENDNKPEF 893
DE++G ++ + +LD E + ++L + A D G + A + I + D ND+ P F
Sbjct: 2789 DESSGTLR-LAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVNDHGPAF 2842
Score = 89.0 bits (211), Expect = 1e-16
Identities = 108/450 (24%), Positives = 195/450 (43%), Gaps = 40/450 (8%)
Query: 454 DNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKI 513
+ P F P E +++ NA GT I +AV G NG + Y + + F I
Sbjct: 2199 ERGPRF-PRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNE---KGTFSI 2253
Query: 514 NPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIPDF 573
P+TG ++V + L+ + + Q + +++ +T++ + P F
Sbjct: 2254 QPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDAND------NAPRF 2307
Query: 574 MGAPYEFWVGSNVGIGTSVGQIRVNDAFEQN--DVSYDLLHGYEEGVPFAVEERSGVITV 631
+ Y ++ + + + Q+ +D + + +SY L F V+ +G IT
Sbjct: 2308 LRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITT 2367
Query: 632 VDDLSRYNRPMYDFEAVALQENANLSIVTNAT--VHVVDVNDERGVLLKGAHSPIIFHVK 689
L R +A + + ++V +AT V V+D ND R + + P V
Sbjct: 2368 TAILDREIWAETRLVLMAT-DRGSPALVGSATLTVMVIDTNDNRPTIPQ----PWELRVS 2422
Query: 690 ENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAE-DGTIFTQKPLDRE 747
E++ G+ I Q+ ++ S G V + + + D ++ G + PLD E
Sbjct: 2423 EDALLGSEIAQVTGNDVDS------GPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFE 2476
Query: 748 KRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIK 807
+ D Y++ ++A + G G +T+ +ED NDN P F + Y+ ++E++ G+ I
Sbjct: 2477 QCDRYQLQLLA--HDGPHEGRA--NLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAIL 2532
Query: 808 MDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVV-KFIGD-SLDREKKIMYKLSL 865
+ ATD D G N Y L + F VD N G + +G +L + + L
Sbjct: 2533 S---VSATDRDSGANGHISYHL-ASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVL 2588
Query: 866 VARDTG--GLSSEAELIIMIGDENDNKPEF 893
ARD G G ++ A + + + D+ND+ P F
Sbjct: 2589 EARDHGAPGRAARATVHVQLQDQNDHAPSF 2618
Score = 89.0 bits (211), Expect = 1e-16
Identities = 117/479 (24%), Positives = 197/479 (41%), Gaps = 55/479 (11%)
Query: 444 NVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTS 503
N+ V + D NDN P F S LY+ + + G+ I V A D D G NG + Y L +
Sbjct: 2497 NLTVLVEDVNDNAPAFSQS-LYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPA 2555
Query: 504 NLTITSPFKINPNTGTVSVAESPILEGRHA-----LFVEASDQPANPSERRYSLAVVTIE 558
+ F ++PN GT+ + G + +EA D A P R + A V ++
Sbjct: 2556 D-----GFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGA-PG--RAARATVHVQ 2607
Query: 559 VTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND---VSYDLLHGYE 615
+ + P F + Y V ++ G+++ + DA V Y ++ G
Sbjct: 2608 L----QDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISG-N 2662
Query: 616 EGVPFAVEERS--------------GVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVT 660
G F +E R G + +++ L + Y+ A S V
Sbjct: 2663 WGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVV 2722
Query: 661 NATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLI 720
TV V+DVND V + ++ + ++ GA ++ H S G VRF +
Sbjct: 2723 PVTVTVLDVNDNPPVFTRASYRVTV--PEDTPVGA---ELLHVEASDADPGPHGLVRFTV 2777
Query: 721 ANQQDVTDDIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIED 779
++ D + + E GT+ LD E + +++ V A G + + VTI ++D
Sbjct: 2778 SSG-DPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAG--AHFALAPVTIEVQD 2834
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-----GEGK 834
ND+ P F + EN GT + + A D D G Y+L EG+
Sbjct: 2835 VNDHGPAFPLNLLSTSVAENQPPGTLV---TTLHAIDGDAGAFGRLRYSLLEAGPGPEGR 2891
Query: 835 EMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEF 893
E F ++ +TG ++ D E ++L + A D G LS+ + +++ E++ P F
Sbjct: 2892 EAFALNSSTGELR-ARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVF 2949
Score = 88.6 bits (210), Expect = 1e-16
Identities = 120/486 (24%), Positives = 194/486 (39%), Gaps = 51/486 (10%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V V + D ND+ P F P + + GT A D D G+ G Y L
Sbjct: 263 VEVTVRVADINDHAPAF-PQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSG- 320
Query: 503 SNLTITSPFKINPNTGTVSVAESPIL-----EGR--HALFVEASDQPANPSERRYSLAVV 555
T + P V E + E R + L +EA D + P + L V
Sbjct: 321 DGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVT 380
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHG 613
+++ P F + Y V ++ G+ V Q+ +DA V+Y++
Sbjct: 381 LLDIN-------DHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYEINRR 433
Query: 614 YEEGV-PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTN-ATVHVVDVND 671
EG PF+++ +G++ + L R +++ A A+ + + TVHV D ND
Sbjct: 434 QSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDAND 493
Query: 672 ERG----VLLKGAHSPIIFHVKENSAGAAI--------GQIFHTNMSSIYGNGTGNVRFL 719
+ + L SP + A G H N+S G G F
Sbjct: 494 NQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEG----HFA 549
Query: 720 IANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIED 779
++ Q V + +A + LDRE+RD Y + V A + G +++ D
Sbjct: 550 LSTQDSVIYLVCVA--------RRLDREERDAYNLRVTAT-DSGSPPLRAEAAFVLHVTD 600
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFD 838
NDN P F+ Y + + + + A D D+GTN Y+L G F
Sbjct: 601 VNDNAPAFDRQLYRPEPLPEVALPGSFVVR--VTARDPDQGTNGQVTYSLAPGAHTHWFS 658
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQI 896
+D +G++ SLD E + +L +VA D G L+S A + + + D NDN+P+F +
Sbjct: 659 IDPTSGIITTAA-SLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRT 717
Query: 897 EENSKV 902
N+ +
Sbjct: 718 FYNASL 723
Score = 87.8 bits (208), Expect = 3e-16
Identities = 115/477 (24%), Positives = 205/477 (42%), Gaps = 47/477 (9%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
+F + +TL DANDN P F+ + F +S G ++ +V+A D D G G + Y L
Sbjct: 2289 AFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLL-QVEADDLDQGSGGQISYSL- 2346
Query: 501 RTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIE 558
++ F ++P TGT++ E L + A+D+ + +L V+ I+
Sbjct: 2347 -AASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVID 2405
Query: 559 VTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGV 618
T N+P IP P+E V + +G+ + Q+ ND + V + +L
Sbjct: 2406 ----TNDNRPTIPQ----PWELRVSEDALLGSEIAQVTGNDV-DSGPVLWYVLSPSGPQD 2456
Query: 619 PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLK 678
PF+V G +++ L Y + +A + N TV V DVND +
Sbjct: 2457 PFSVGRYGGRVSLTGPLDFEQCDRYQLQLLA--HDGPHEGRANLTVLVEDVNDNAPAFSQ 2514
Query: 679 GAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTI 738
+ ++ ++ G+AI + T+ S G++ + +A+ D +GT+
Sbjct: 2515 SLYQVML--LEHTPPGSAILSVSATDRDS---GANGHISYHLASPADGFS--VDPNNGTL 2567
Query: 739 FT---QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
FT L + + + A + G A V + ++D+ND+ P F + Y
Sbjct: 2568 FTIVGTVALGHDGSGAVDVVLEAR-DHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVA 2626
Query: 796 IMENSKIGTEIKMDNIIKATDAD-EGTNALFMYTLF-GEGKEMFDVD-------ENTGV- 845
+ E+ G+ + ++ATDAD ++A Y++ G +F ++ E+ G
Sbjct: 2627 VTEDLPPGSTLL---TLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPG 2683
Query: 846 VKFIG-----DSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ 895
+ +G + LD E Y L++ A D G SS + + + D NDN P F +
Sbjct: 2684 PRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTR 2740
Score = 82.6 bits (195), Expect = 1e-14
Identities = 135/605 (22%), Positives = 235/605 (38%), Gaps = 65/605 (10%)
Query: 897 EENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFL--IPENIPIGTTIIKLN 954
E + ++R+ + + G FT++ + ++ L P ++ +PE+ P+ ++++
Sbjct: 2271 EVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVE 2330
Query: 955 ALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SE 1012
A DLD G GQI Y A + + F ++ G + L E +E
Sbjct: 2331 ADDLDQGSGGQISYSL------------AASQPARGLFHVDPTTGTITTTAILDREIWAE 2378
Query: 1013 FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDAT 1070
RL + A D G+ L + ++ V V D ND+ P + W V E + +V
Sbjct: 2379 TRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQPW-ELRVSEDALLGSEIAQVTGN 2437
Query: 1071 DADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXX 1130
D D G L Y + PS PF + G +S+ G LD E D+Y L ++A D
Sbjct: 2438 DVDSGPV--LWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG----P 2491
Query: 1131 XXXXXXXXXXXXDVNDNSPKF-YAFDELLEWKH------------PEADELSNHNFESVM 1177
DVNDN+P F + +++ +H + D +N + +
Sbjct: 2492 HEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHL 2551
Query: 1178 MIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAI 1237
P +++ N T+ A D G+G + L R + G P ++ A
Sbjct: 2552 ASPADGFSVDPNNGTLFTIVGTVALGHD----GSGAVDVVLEARDH----GAPGRAARAT 2603
Query: 1238 LMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTE---HYENFKMRYYI 1294
+ V + D D P F +Y + + E++ L++L T+ + + Y I
Sbjct: 2604 VHVQLQDQNDHA-----PSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSI 2658
Query: 1295 LNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAED 1354
++ N R F ++PR P +V E + + + A D
Sbjct: 2659 ISGN---WGRVFQLEPRLAEAGESAGPGPR---ALGCLVLLEPLDFESLTQYNLTVAAAD 2712
Query: 1355 VLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQLKGA---IGHH 1411
+ V V V + DVNDN P FT + + +P P G +++ ++ + G H
Sbjct: 2713 RGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRV--TVPEDTPVGAELLHVEASDADPGPH 2770
Query: 1412 PTASRTVRADTDELVFFERLSLNGLTSPQATDSDIGINADIRYQILNEQAPRFAIDPVSG 1471
TV + +F S L A D + + Q + FA+ PV+
Sbjct: 2771 GLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAPVTI 2830
Query: 1472 TVRVV 1476
V+ V
Sbjct: 2831 EVQDV 2835
Score = 81.0 bits (191), Expect = 3e-14
Identities = 87/329 (26%), Positives = 137/329 (41%), Gaps = 19/329 (5%)
Query: 68 VRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIF--LIAPIG 125
VR G+G+ A V V ++DVNDN P F V + T G + L G
Sbjct: 1001 VRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSG 1060
Query: 126 PSLTIPLTVPRG----LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
+ + T+ G T+ +P P+ + + DG +SH
Sbjct: 1061 VNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSH--- 1117
Query: 182 LLLRKVLDYDAGDKEFQLVIMASGKRIH--KEILFPEPIHAIDQDLGVGATLRYELISGN 239
LR V+ D G + + R+ + + G + Y L +
Sbjct: 1118 FRLRVVVQ-DVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGPITYHLAAEG 1176
Query: 240 DRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
F L+ +G L++ LD +A+ V+ V S+ +T A V + +L+
Sbjct: 1177 ASSPFGLEPQSGWLWVRAALDREAQELYILK--VMAVSGSKAELGQQTGTATVRVSILNQ 1234
Query: 300 NDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTY---QLDDPKGAFSIDP 356
N++ P D +++ EN P G SV +V ATD+D G NG TY QL + AF I P
Sbjct: 1235 NEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHP 1294
Query: 357 RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
++G +T QT LDRE SS ++ V ++
Sbjct: 1295 QTGEVTTL-QT-LDREQQSSYQLLVQVQD 1321
Score = 79.8 bits (188), Expect = 7e-14
Identities = 117/433 (27%), Positives = 178/433 (41%), Gaps = 45/433 (10%)
Query: 919 IEVKPKNKFALDVDQLGPLFL-IPENIPIGTTIIKLNALDLDS-GLNGQIRYEF-NSEVY 975
++V+ +N+ A + PL L +PEN G + A D D G N +RY E
Sbjct: 1560 VQVQDENEHAPAFAR-DPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPP 1618
Query: 976 IPPSKLSA--DALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRV 1033
+P +L A AL R +++ + + +A +S RV
Sbjct: 1619 VPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAA--------RVSARV 1670
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPF 1093
FV D ND+ PVF + E Q V A D D G+ A ++Y + S D F
Sbjct: 1671 FVTDENDNAPVFASP-SRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLA-SGGDGHF 1728
Query: 1094 EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF-- 1151
+ TG LSV LDRE +++LTVVA D+G DVND +P F
Sbjct: 1729 RLHSSTGALSVVRPLDREQRAEHVLTVVASDHG-SPPRSATQVLTVSVADVNDEAPTFQQ 1787
Query: 1152 YAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPI--GTTVAKVFANDTDFIGN 1209
+ LL +P S++ + + N + G ++ F+ D D
Sbjct: 1788 QEYSVLLRENNPPG--------TSLLTLRATDPDVGANGQVTYGGVSSESFSLDPD---T 1836
Query: 1210 GNGLILYSLPQRKNQQNLGLPSL-----SSTAILMVTVADVPDEVEMSDKPVFISRYYEL 1264
G L +L R+ Q+ + L S + VTV V E E P F S + L
Sbjct: 1837 GVLTTLRAL-DREEQEEINLTVYAQDRGSPPQLTHVTVR-VAVEDENDHAPTFGSAHLSL 1894
Query: 1265 EIEENVNAPVELVSLNLTEH--YENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPD 1322
E+ E + P L L ++ N +++Y IL D D FV+D +G +R D
Sbjct: 1895 EVPEGQD-PQTLTMLRASDPDVGANGQLQYRIL---DGDPSGAFVLDLASGEFGTMRPLD 1950
Query: 1323 REVKDTYEVIVRA 1335
REV+ +++ + A
Sbjct: 1951 REVEPAFQLRIEA 1963
Score = 78.6 bits (185), Expect = 2e-13
Identities = 51/181 (28%), Positives = 88/181 (48%), Gaps = 10/181 (5%)
Query: 207 RIHKEILFPEPIHAID-QDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEH 265
R+ ++ L I + D+ G L Y L + FS+ G + L LD +
Sbjct: 2420 RVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFE--- 2476
Query: 266 NLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSV 325
Q + + LQ+ A + P + +A + + + D+NDN P F Y + ++E+ P G ++
Sbjct: 2477 --QCDRYQLQLLAH--DGPHE-GRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAI 2531
Query: 326 LQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWL-TVRNQTVLDREAHSSLRMKVYAK 384
L V ATD+D G NG +Y L P FS+DP +G L T+ L + ++ + + A+
Sbjct: 2532 LSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEAR 2591
Query: 385 E 385
+
Sbjct: 2592 D 2592
Score = 76.2 bits (179), Expect = 9e-13
Identities = 109/467 (23%), Positives = 177/467 (37%), Gaps = 35/467 (7%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLT 506
V++ D ND P F Y ++ N GT + ++A DPD+G NG V Y
Sbjct: 1773 VSVADVNDEAPTFQQQE-YSVLLRENNPPGTSLLTLRATDPDVGANGQVTY------GGV 1825
Query: 507 ITSPFKINPNTGTVSVAESPILEGRHA--LFVEASDQPANPSERRYSLAVVTIEVTRGTK 564
+ F ++P+TG ++ + E + L V A D+ + P L VT+ V +
Sbjct: 1826 SSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPP-----QLTHVTVRV--AVE 1878
Query: 565 GNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN--DAFEQNDVSYDLLHGYEEGVPFAV 622
P F A V T + +R + D + Y +L G G F +
Sbjct: 1879 DENDHAPTFGSAHLSLEVPEGQDPQT-LTMLRASDPDVGANGQLQYRILDGDPSGA-FVL 1936
Query: 623 EERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTNATVHVVDVNDERGVLLKGAH 681
+ SG + L R P + A LS TV V+D ND A+
Sbjct: 1937 DLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAY 1996
Query: 682 SPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQ 741
S + ++ AG + Q+ + + G+V + + + G + T
Sbjct: 1997 SVEV--PEDVPAGTLLLQLQAHDPDA---GANGHVTYYL-GAGTAGAFLLEPSSGELRTA 2050
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE-GFIMENS 800
LDRE+ Y +V A + VTI + D ND+ P F +
Sbjct: 2051 AALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGP 2110
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD--SLDREKK 858
T ++A D D G NA +Y L G VD TG ++ +L +
Sbjct: 2111 SFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDR 2170
Query: 859 IMYKLSLVARDTGGLSSEAELIIMIG--DENDNKPEFNQIEENSKVR 903
+++ +VA D G + A +I++G E + P F + + +R
Sbjct: 2171 VLF---IVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIR 2214
Score = 74.9 bits (176), Expect = 2e-12
Identities = 111/459 (24%), Positives = 183/459 (39%), Gaps = 34/459 (7%)
Query: 451 DANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSP 510
D NDN P F + A G+ + +V A DPD G NG V Y L ++ T
Sbjct: 600 DVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAH---THW 656
Query: 511 FKINPNTGTVSVAESPI--LEGRHALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKP 568
F I+P +G ++ A S LE + L V A+D P +++V +V
Sbjct: 657 FSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNE----- 711
Query: 569 DIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQ--NDVSYDLLHGYEEG--VPFAVEE 624
P F Y + GT Q+ DA +SY L G PF ++
Sbjct: 712 --PQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDA 769
Query: 625 RSGVITVVDDLSRYNRPM-YDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSP 683
SG + L R P +DF A+ + L + V + D ND ++
Sbjct: 770 HSGDVCTTRTLDRDQGPSSFDFTVTAV-DGGGLKSMVYVKVFLSDENDNPPQFYPREYAA 828
Query: 684 IIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDV-TDDIAIAEDGTIFTQK 742
I ++ G A+ ++ + +G + L N + T D + G +
Sbjct: 829 SIS--AQSPPGTAVLRL-RAHDPDQGSHGRLSYHILAGNSPPLFTLD---EQSGLLTVAW 882
Query: 743 PLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKI 802
PL R V ++ + AE + G + +V I I PP+FE Y + E+
Sbjct: 883 PLARRANSVVQLEIGAE-DGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAP 941
Query: 803 GTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYK 862
GT + I++A + + + G+ + +F +D +G+++ + LDRE +
Sbjct: 942 GTSV---GIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTL-RPLDRE-LLGPV 996
Query: 863 LSLVARDTGGLS---SEAELIIMIGDENDNKPEFNQIEE 898
L L R G+ + A + +++ D NDN P F E+
Sbjct: 997 LELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPED 1035
Score = 74.5 bits (175), Expect = 3e-12
Identities = 86/302 (28%), Positives = 126/302 (41%), Gaps = 28/302 (9%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI--APIGPSLTIPLTV- 134
S+ + VTV + DVNDN P+F Y VTV E TP G + A GP + TV
Sbjct: 2719 SSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVS 2778
Query: 135 ---PRGLTIFKDIRAFDR--DKPNTPNSDVHYSIVSGNDDG--HFALESSHKPVLLLRKV 187
P GL + R + H +V D HFAL PV + +V
Sbjct: 2779 SGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFALA----PVTI--EV 2832
Query: 188 LDYDAGDKEFQLVIMASGKRIHKEI-LFPEPIHAIDQDLGVGATLRYELISGND----RK 242
D + F L ++++ ++ +HAID D G LRY L+ R+
Sbjct: 2833 QDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGRE 2892
Query: 243 LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDN 302
F+L+S G L + D EH +F L V A+ N +A V + + ++
Sbjct: 2893 AFALNSSTGEL--RARVPFDYEHT---ESFRLLVGAADAGN--LSASVTVSVLVTGEDEY 2945
Query: 303 LPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLT 362
P F ++ + E G S+ V ATD+D G +G Y L F I+ +G L
Sbjct: 2946 DPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALY 3005
Query: 363 VR 364
+R
Sbjct: 3006 LR 3007
Score = 74.1 bits (174), Expect = 3e-12
Identities = 55/186 (29%), Positives = 90/186 (48%), Gaps = 16/186 (8%)
Query: 212 ILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANT 271
I+ P +HA G + Y ++SGN++ FS+ G++ + LD E + +
Sbjct: 2223 IVSPRAVHAG----GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLR- 2277
Query: 272 FVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMAT 331
VLQ ++ A + + L D NDN P F Y + E+ P +LQV A
Sbjct: 2278 LVLQAESGGA-----FAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEAD 2332
Query: 332 DKDQGENGEFTYQL---DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKET-N 387
D DQG G+ +Y L +G F +DP +G T+ +LDRE + R+ + A + +
Sbjct: 2333 DLDQGSGGQISYSLAASQPARGLFHVDPTTG--TITTTAILDREIWAETRLVLMATDRGS 2390
Query: 388 PSVVGT 393
P++VG+
Sbjct: 2391 PALVGS 2396
Score = 73.7 bits (173), Expect = 5e-12
Identities = 110/462 (23%), Positives = 174/462 (37%), Gaps = 30/462 (6%)
Query: 440 MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
++ V V V + D ND+ P F ++L + T + ++A DPD+G NG + Y +
Sbjct: 1868 LTHVTVRVAVEDENDHAPTFGSAHL-SLEVPEGQDPQT-LTMLRASDPDVGANGQLQYRI 1925
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEV 559
+ GT+ + + E L +EA D P+ L VT+
Sbjct: 1926 LDGDPSGAFVLDLASGEFGTMRPLDREV-EPAFQLRIEARD-GGQPALSATLLLTVTV-- 1981
Query: 560 TRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN--DAFEQNDVSYDLLHGYEEG 617
P F Y V +V GT + Q++ + DA V+Y L G
Sbjct: 1982 ----LDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYL--GAGTA 2035
Query: 618 VPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA--NLSIVTNATVHVVDVNDERGV 675
F +E SG + L R P Y F A+ A LS + T+ V DVND
Sbjct: 2036 GAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPT 2095
Query: 676 LLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFL--IANQQDVTDDIAIA 733
SP+ + + + + + + N L +A +
Sbjct: 2096 F---PTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSY 2152
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
+ P+ RD V + + S G+ + + ++ E + P F A+ E
Sbjct: 2153 TGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGV--IIVGLQGEAERGPRFPRASSE 2210
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYT-LFGEGKEMFDVDENTGVVKF-IGD 851
I EN+ GT I + A GTN Y+ L G K F + +TG + +
Sbjct: 2211 ATIRENAPPGTPIVSPRAVHA----GGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAE 2266
Query: 852 SLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEF 893
LD E +L L A ++GG + L + + D NDN P F
Sbjct: 2267 GLDFEVSPRLRLVLQA-ESGGAFAFTVLTLTLQDANDNAPRF 2307
Score = 73.3 bits (172), Expect = 6e-12
Identities = 70/218 (32%), Positives = 102/218 (46%), Gaps = 24/218 (11%)
Query: 689 KENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ-QDVTDDIAIAE-DGTIFTQKPLDR 746
+E AG IG I + G + F+ A + V D+AI E G + T + LDR
Sbjct: 189 EEQPAGTLIGDI---SAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVLDR 245
Query: 747 EKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEI 806
E+RD YR T + GA + +VT+ + D ND+ P F A + E++ GT
Sbjct: 246 EQRDRYRFTAVTP------DGATV-EVTVRVADINDHAPAFPQARAALQVPEHTAFGTRY 298
Query: 807 KMDNIIKATDADEGTNALFMYTLFGEGK-EMFDVD-----ENTGVVKF-IGDSLDREKKI 859
++ A DAD G Y L G+G E F ++ + T V + + LDRE +
Sbjct: 299 PLE---PARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRS 355
Query: 860 MYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
Y L L A D G ++A L + + D ND+ P FNQ
Sbjct: 356 HYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQ 393
Score = 73.3 bits (172), Expect = 6e-12
Identities = 66/221 (29%), Positives = 97/221 (43%), Gaps = 24/221 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PE G+ ++++ A D D G NGQ+ Y + +F I+ G
Sbjct: 618 LPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHT-------------HWFSIDPTSG 664
Query: 1000 HVIVARSLPPESEFR--LNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+ A SL E E + L + A DGG L + +V V ++DVND+ P F++T+YN ++
Sbjct: 665 IITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLP 724
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQP---SDTDLPFEISPLTGVLSVNGELDRET 1112
E +V ATDAD G L+Y + S PF I +G + LDR+
Sbjct: 725 EGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQ 784
Query: 1113 -EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY 1152
+ TV A D G D NDN P+FY
Sbjct: 785 GPSSFDFTVTAVDGG---GLKSMVYVKVFLSDENDNPPQFY 822
Score = 72.9 bits (171), Expect = 8e-12
Identities = 78/293 (26%), Positives = 124/293 (42%), Gaps = 29/293 (9%)
Query: 617 GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDE---- 672
G A++E SGV+ L R R Y F AV + A + + TV V D+ND
Sbjct: 225 GTDLAIDEHSGVVRTARVLDREQRDRYRFTAVT-PDGATVEV----TVRVADINDHAPAF 279
Query: 673 ---RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
R L H+ A A T ++ G+G G F + + D
Sbjct: 280 PQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGET-FRLETRPG-PDG 337
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
+ E + LDRE R Y M + ++ G + + + D ND+ P F
Sbjct: 338 TPVPE---LVVTGELDRENRSHY-MLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQ 393
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL---FGEGKEMFDVDENTGVV 846
+ Y + E+ G+ + + A+DAD G N Y + EG F +D +TG++
Sbjct: 394 SRYHAVVSESLAPGSPVLQ---VFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLL 450
Query: 847 KFIGDSLDREKKIMYKLSLVARDTGGLSSE---AELIIMIGDENDNKPEFNQI 896
+ + LD E++ +++L + ARD GG E A + + + D NDN+P I
Sbjct: 451 Q-LERPLDFEQRRVHELVVQARD-GGAHPELGSAFVTVHVRDANDNQPSMTVI 501
Score = 72.9 bits (171), Expect = 8e-12
Identities = 90/308 (29%), Positives = 125/308 (40%), Gaps = 26/308 (8%)
Query: 83 VTVYIEDVNDNVP----IFLDTPYHVTVDELTPTGEK-AFIFLIAPI-GPSLTIPLTVPR 136
VTV++ D NDN P IFL V E P G+ A I + P G + +++
Sbjct: 484 VTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEG 543
Query: 137 GLTIF----KDIRAF---DRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLD 189
G F +D + + + D + V+ D G L + VL + V D
Sbjct: 544 GEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVND 603
Query: 190 YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSV 249
+A + QL + F + A D D G + Y L G FS+D
Sbjct: 604 -NAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPT 662
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
+G + LD + E Q L V A+ P + A V + L D+NDN P+F+
Sbjct: 663 SGIITTAASLDYELEPQPQ-----LIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRT 717
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGA-----FSIDPRSGWLTVR 364
FYN S+ E G LQV ATD D G G +Y L G+ F ID SG V
Sbjct: 718 FYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSG--DVC 775
Query: 365 NQTVLDRE 372
LDR+
Sbjct: 776 TTRTLDRD 783
Score = 72.1 bits (169), Expect = 1e-11
Identities = 91/359 (25%), Positives = 148/359 (41%), Gaps = 29/359 (8%)
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTS--VGQIRVNDAFEQNDVSYDLLHG 613
T+EVT P F A V + GT + R DA Y L G
Sbjct: 262 TVEVTVRVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGY-ALSG 320
Query: 614 YEEGVPFAVEERSGV-------ITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATVH 665
G F +E R G + V +L R NR Y + A + V
Sbjct: 321 DGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVT 380
Query: 666 VVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD 725
++D+ND + + ++ + + G+ + Q+F ++ + G V + I +Q
Sbjct: 381 LLDINDHAPAFNQSRYHAVVS--ESLAPGSPVLQVFASDADA---GVNGAVTYEINRRQS 435
Query: 726 VTDD-IAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDN 783
D +I A G + ++PLD E+R V+ + V A + G G VT+++ D NDN
Sbjct: 436 EGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQAR-DGGAHPELGSAFVTVHVRDANDN 494
Query: 784 PP----VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG-EGKEMFD 838
P +F A + E + G + I +D D+G A +L G EG
Sbjct: 495 QPSMTVIFLSADGSPQVSEAAPPGQLVAR---ISVSDPDDGDFAHVNVSLEGGEGHFALS 551
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
++ + + LDRE++ Y L + A D+G L +EA ++ + D NDN P F++
Sbjct: 552 TQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDR 610
Score = 72.1 bits (169), Expect = 1e-11
Identities = 55/172 (31%), Positives = 87/172 (50%), Gaps = 8/172 (4%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLE-KELDLDAEHNLQANT-FVLQVQ 277
A D D G T Y L + F L++ G EL + E + + + ++LQ++
Sbjct: 303 ARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENRSHYMLQLE 362
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A +P + AQA +++ LLD+ND+ P F Y+ + E+L G VLQV A+D D G
Sbjct: 363 AYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGV 422
Query: 338 NGEFTYQLD----DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
NG TY+++ + G FSID +G L + + LD E + V A++
Sbjct: 423 NGAVTYEINRRQSEGDGPFSIDAHTGLLQL--ERPLDFEQRRVHELVVQARD 472
Score = 70.1 bits (164), Expect = 6e-11
Identities = 117/471 (24%), Positives = 189/471 (40%), Gaps = 36/471 (7%)
Query: 441 SFVNVEVTLLDANDNNP----VFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
+FV V V DANDN P +F+ ++ + A G ++ ++ DPD G V
Sbjct: 482 AFVTVHVR--DANDNQPSMTVIFLSADGSP-QVSEAAPPGQLVARISVSDPDDGDFAHVN 538
Query: 497 YDLQR-TSNLTITSPFKINPNTGTVSVAESPILEGRHA--LFVEASDQPANPSERRYSLA 553
L+ + +++ + V VA E R A L V A+D + P A
Sbjct: 539 VSLEGGEGHFALSTQDSV---IYLVCVARRLDREERDAYNLRVTATDSGSPPLRAE---A 592
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHG 613
+ VT N P + P + G R D V+Y L G
Sbjct: 593 AFVLHVT-DVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPG 651
Query: 614 YEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV--DVND 671
F+++ SG+IT L P VA + + ++ATV V DVND
Sbjct: 652 AHTHW-FSIDPTSGIITTAASLDYELEPQPQLIVVAT-DGGLPPLASSATVSVALQDVND 709
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSS-IYGNGTGNVRFLIANQQDVTDDI 730
+ ++ + + G Q+ T+ S +G + ++ + + I
Sbjct: 710 NEPQFQRTFYNASL--PEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRI 767
Query: 731 AIAEDGTIFTQKPLDREKR-DVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
A G + T + LDR++ + TV A G+ S + V +++ DENDNPP F
Sbjct: 768 D-AHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKS---MVYVKVFLSDENDNPPQFYP 823
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMY-TLFGEGKEMFDVDENTGVVKF 848
Y I S GT + ++A D D+G++ Y L G +F +DE +G++
Sbjct: 824 REYAASISAQSPPGTAVLR---LRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLT- 879
Query: 849 IGDSLDREKKIMYKLSLVARDTGGLSSE--AELIIMIGDENDNKPEFNQIE 897
+ L R + +L + A D GGL +E A + I I P F Q++
Sbjct: 880 VAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQ 930
Score = 69.3 bits (162), Expect = 1e-10
Identities = 50/156 (32%), Positives = 69/156 (44%), Gaps = 6/156 (3%)
Query: 1001 VIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFN-VE 1055
V VAR L E + L ++A D G+ L + + V DVND+ P F + Y +
Sbjct: 560 VCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLP 619
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E + +V A D D G N +TY + P F I P +G+++ LD E E +
Sbjct: 620 EVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQ 679
Query: 1116 YILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
L VVA D G DVNDN P+F
Sbjct: 680 PQLIVVATDGG-LPPLASSATVSVALQDVNDNEPQF 714
Score = 68.9 bits (161), Expect = 1e-10
Identities = 72/261 (27%), Positives = 101/261 (38%), Gaps = 18/261 (6%)
Query: 897 EENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNAL 956
E+ + R T T T+ V N A Q +PE+ GT A
Sbjct: 246 EQRDRYRFTAVTPDGATVEVTV-RVADINDHAPAFPQARAALQVPEHTAFGTRYPLEPAR 304
Query: 957 DLDSGLNGQIRYEFNS----EVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE 1012
D D+G G Y + E + ++ D V V E S
Sbjct: 305 DADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRE--------NRSH 356
Query: 1013 FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDAT 1070
+ L + A DGG+ + V + D+NDH P F ++ Y+ V E+ + +V A+
Sbjct: 357 YMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFAS 416
Query: 1071 DADFGQNANLTYFI--QPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXX 1128
DAD G N +TY I + S+ D PF I TG+L + LD E + L V ARD G
Sbjct: 417 DADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGG-A 475
Query: 1129 XXXXXXXXXXXXXXDVNDNSP 1149
D NDN P
Sbjct: 476 HPELGSAFVTVHVRDANDNQP 496
Score = 67.7 bits (158), Expect = 3e-10
Identities = 79/288 (27%), Positives = 111/288 (38%), Gaps = 49/288 (17%)
Query: 939 LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERH 998
L+P N GT I L ALD DSG+N ++ + L+ F ++
Sbjct: 1038 LLPPNTAPGTPIYTLRALDPDSGVNSRVTFTL----------LAGGG----GAFTVDPTT 1083
Query: 999 GHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDH--FPVFKKTWYNF 1052
GHV + R L P L + A DGG+ + +RV V+DV P F Y
Sbjct: 1084 GHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRV 1143
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRET 1112
++ + +V A D G +TY + PF + P +G L V LDRE
Sbjct: 1144 DLPSGTTAGTQVLQVQAQAPDGGP---ITYHLAAEGASSPFGLEPQSGWLWVRAALDREA 1200
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHN 1172
++ YIL V+A +N N + LS
Sbjct: 1201 QELYILKVMAVSGSKAELGQQTGTATVRVSILNQNE---------------HSPRLSED- 1244
Query: 1173 FESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQ 1220
P + A + EN P GT+V +VFA D D NG + YSL Q
Sbjct: 1245 -------PTFLA-VAENQPPGTSVGRVFATDRD--SGPNGRLTYSLQQ 1282
Score = 67.3 bits (157), Expect = 4e-10
Identities = 107/467 (22%), Positives = 188/467 (40%), Gaps = 34/467 (7%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L S V V+V L D NDN P F P Y S+ + + GT + +++A DPD G +G + Y
Sbjct: 801 LKSMVYVKVFLSDENDNPPQFYPRE-YAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYH 859
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIE 558
+ ++ + F ++ +G ++VA + +E + + S A V I
Sbjct: 860 ILAGNSPPL---FTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPS-ARVDIS 915
Query: 559 VTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV-NDAFEQNDVSYDLLHGYEEG 617
+ GT P P F Y F V +V GTSVG ++ N V+ L G G
Sbjct: 916 IVPGT----PTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRG 971
Query: 618 VPFAVEERSGVITVVDDLSR-YNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVL 676
+ F+++ SG++ + L R P+ + E A V V + DVND
Sbjct: 972 L-FSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAF 1030
Query: 677 LKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDG 736
A + + G I + + S N L T D G
Sbjct: 1031 --PAPEDTVLLPPNTAPGTPIYTLRALDPDSGV-NSRVTFTLLAGGGGAFTVD---PTTG 1084
Query: 737 TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDN--PPVFEHATYEG 794
+ +PL + + + A + G +++ + ++D P F TY
Sbjct: 1085 HVRLMRPLGPSGGPAHELELEAR-DGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRV 1143
Query: 795 FIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG-KEMFDVDENTGVVKFIGDSL 853
+ + GT++ ++A D G Y L EG F ++ +G + ++ +L
Sbjct: 1144 DLPSGTTAGTQVLQ---VQAQAPDGGP---ITYHLAAEGASSPFGLEPQSGWL-WVRAAL 1196
Query: 854 DREKKIMYKLSLVA-----RDTGGLSSEAELIIMIGDENDNKPEFNQ 895
DRE + +Y L ++A + G + A + + I ++N++ P ++
Sbjct: 1197 DREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSE 1243
Score = 67.3 bits (157), Expect = 4e-10
Identities = 52/168 (30%), Positives = 75/168 (44%), Gaps = 9/168 (5%)
Query: 992 FVINERHGHVIVARSLPPESE--FRLNISALDG-----GNLNDNISVRVFVKDVNDHFPV 1044
F + + G + V +L E++ + L + A+ G G +VRV + + N+H P
Sbjct: 1181 FGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPR 1240
Query: 1045 FKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQP-SDTDLPFEISPLTGVLS 1103
+ V E Q +G+V ATD D G N LTY +Q S+ F I P TG ++
Sbjct: 1241 LSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVT 1300
Query: 1104 VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
LDRE + Y L V +D G D+NDNSP F
Sbjct: 1301 TLQTLDREQQSSYQLLVQVQDGG-SPPRSTTGTVHVAVLDLNDNSPTF 1347
Score = 66.9 bits (156), Expect = 5e-10
Identities = 61/218 (27%), Positives = 95/218 (43%), Gaps = 8/218 (3%)
Query: 940 IPENIPIGTTIIKLNALDLD-SGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERH 998
+ E++P G+T++ L A D D S + + Y S + +L E R
Sbjct: 2627 VTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRA 2686
Query: 999 -GHVIVARSLPPES--EFRLNISALDGGNLNDN--ISVRVFVKDVNDHFPVFKKTWYNFN 1053
G +++ L ES ++ L ++A D G + + V V V DVND+ PVF + Y
Sbjct: 2687 LGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVT 2746
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETE 1113
V E L V+A+DAD G + + + + D FE+ +G L + LD ET+
Sbjct: 2747 VPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQ 2806
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
++ L V A D DVND+ P F
Sbjct: 2807 ARHQLVVQAAD--PAGAHFALAPVTIEVQDVNDHGPAF 2842
Score = 66.9 bits (156), Expect = 5e-10
Identities = 55/182 (30%), Positives = 81/182 (44%), Gaps = 20/182 (10%)
Query: 930 DVDQLGPLF-------LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLS 982
DV+ GP F + EN P GT + L+A+D D+G G++RY +
Sbjct: 2834 DVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLE---------A 2884
Query: 983 ADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVND 1040
E + F +N G + E FRL + A D GNL+ +++V V V ++
Sbjct: 2885 GPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDE 2944
Query: 1041 HFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG 1100
+ PVF ++F V E LG V ATD D G + + Y + S F I+ TG
Sbjct: 2945 YDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSP--YFGINQTTG 3002
Query: 1101 VL 1102
L
Sbjct: 3003 AL 3004
Score = 66.1 bits (154), Expect = 9e-10
Identities = 57/174 (32%), Positives = 83/174 (47%), Gaps = 14/174 (8%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G +R+ + SG+ LF LD +G+L L LD + + Q L VQ
Sbjct: 2760 VEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQ-----LVVQ 2814
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A+ A A V IE+ D+ND+ P F ++ + S+ EN P G V + A D D G
Sbjct: 2815 AADPAGA-HFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGA 2873
Query: 338 NGEFTYQL----DDPKG--AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
G Y L P+G AF+++ +G L R + D E S R+ V A +
Sbjct: 2874 FGRLRYSLLEAGPGPEGREAFALNSSTGEL--RARVPFDYEHTESFRLLVGAAD 2925
Score = 65.3 bits (152), Expect = 2e-09
Identities = 51/190 (26%), Positives = 82/190 (43%), Gaps = 13/190 (6%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PE GT +++ A D DSG G + Y + + S F I+ G
Sbjct: 723 LPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSP----------PFRIDAHSG 772
Query: 1000 HVIVARSLPPE---SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
V R+L + S F ++A+DGG L + V+VF+ D ND+ P F Y ++
Sbjct: 773 DVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNPPQFYPREYAASISA 832
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKY 1116
+ ++ A D D G + L+Y I ++ F + +G+L+V L R
Sbjct: 833 QSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVV 892
Query: 1117 ILTVVARDNG 1126
L + A D G
Sbjct: 893 QLEIGAEDGG 902
Score = 65.3 bits (152), Expect = 2e-09
Identities = 44/127 (34%), Positives = 64/127 (50%), Gaps = 7/127 (5%)
Query: 261 LDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLP 320
LD E Q N L V A+ P +++ V + +LD+NDN P F Y +++ E+ P
Sbjct: 2696 LDFESLTQYN---LTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTP 2752
Query: 321 NGFSVLQVMATDKDQGENG--EFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLR 378
G +L V A+D D G +G FT DP G F +D SG T+R LD E + +
Sbjct: 2753 VGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSG--TLRLAHALDCETQARHQ 2810
Query: 379 MKVYAKE 385
+ V A +
Sbjct: 2811 LVVQAAD 2817
Score = 64.9 bits (151), Expect = 2e-09
Identities = 117/491 (23%), Positives = 195/491 (39%), Gaps = 69/491 (14%)
Query: 939 LIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADA----LEVKRYFVI 994
++ E++ G+ ++++ A D D+G+NG + YE N S DA L+++R
Sbjct: 399 VVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDF 458
Query: 995 NERHGHVIVARSLPPESEFRLNISALDGGNLND--NISVRVFVKDVNDHFP----VFKKT 1048
+R H +V + A DGG + + V V V+D ND+ P +F
Sbjct: 459 EQRRVHELV-------------VQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSA 505
Query: 1049 WYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISP-LTGVLSVNGE 1107
+ V EA +++ ++ +D D G A++ ++ + + ++ V
Sbjct: 506 DGSPQVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARR 565
Query: 1108 LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE 1167
LDRE D Y L V A D+G DVNDN+P AFD L P +
Sbjct: 566 LDREERDAYNLRVTATDSG-SPPLRAEAAFVLHVTDVNDNAP---AFDRQLYRPEPLPEV 621
Query: 1168 LSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLIL------YSL-PQ 1220
+F V+ + N + ++A I +G+I Y L PQ
Sbjct: 622 ALPGSF--VVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQ 679
Query: 1221 RK---NQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELV 1277
+ + GLP L+S+A + V + DV D ++P F +Y + E +
Sbjct: 680 PQLIVVATDGGLPPLASSATVSVALQDVND-----NEPQFQRTFYNASLPEGTQPGTCFL 734
Query: 1278 SLNLTEHYEN-FKMRYYILNEN-DTDIRRTFVIDPRNGTLYLVRSPDREV-KDTYEVIVR 1334
+ T+ F + Y L + F ID +G + R+ DR+ +++ V
Sbjct: 735 QVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVT 794
Query: 1335 AERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTT 1394
A V G K V V V + D NDN P+F R +I
Sbjct: 795 A-------------------VDGGGLKSMVYVKVFLSDENDNPPQFY--PREYAASISAQ 833
Query: 1395 APFGYQVMQLK 1405
+P G V++L+
Sbjct: 834 SPPGTAVLRLR 844
Score = 64.9 bits (151), Expect = 2e-09
Identities = 50/179 (27%), Positives = 75/179 (41%), Gaps = 13/179 (7%)
Query: 218 IHAIDQDLGVGATLRYELIS-GNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D+D G L Y L D K F + G + + LD + Q +++ L V
Sbjct: 1263 VFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDRE-----QQSSYQLLV 1317
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEF------EVDFYNISIVENLPNGFSVLQVMA 330
Q +P ++ V + +LDLNDN P F I + + +P G V + A
Sbjct: 1318 QVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQA 1377
Query: 331 TDKDQGENGEFTYQLDDP-KGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
D D+GENG Y L P FS+ P SG L + H L + + + + P
Sbjct: 1378 KDPDEGENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPP 1436
Score = 64.9 bits (151), Expect = 2e-09
Identities = 95/382 (24%), Positives = 158/382 (41%), Gaps = 41/382 (10%)
Query: 992 FVINERHGHVIVARSLPPES--EFR-LNISALDGGNLNDNI-SVRVFVKDVNDHFPVFKK 1047
F ++ G + +AR L E+ +R L + A G + V+V V+D N+H P F +
Sbjct: 1515 FALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFAR 1574
Query: 1048 TWYNFNVEEAQYTRRVLGKVDATDADF-GQNANLTYFIQPSDTDLP-FEISPLTGVLSVN 1105
+ E L A+DAD G N+++ Y + + +P + TG LS
Sbjct: 1575 DPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAP 1634
Query: 1106 GELDRETEDKYILTVVARDN--GXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHP 1163
LDRET +L V A D D NDN+P F + + + P
Sbjct: 1635 RGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPSRV---RLP 1691
Query: 1164 EADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDF-IGNGNGLILYSLPQRK 1222
E D+ + + + + E A + +A D F + + G + P +
Sbjct: 1692 E-DQPPG---PAALHVVARDPDLGEAARVSYRLAS--GGDGHFRLHSSTGALSVVRPLDR 1745
Query: 1223 NQQ----------NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNA 1272
Q+ + G P S+T +L V+VADV DE P F + Y + + EN
Sbjct: 1746 EQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEA-----PTFQQQEYSVLLRENNPP 1800
Query: 1273 PVELVSLNLTEH--YENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYE 1330
L++L T+ N ++ Y ++ +F +DP G L +R+ DRE ++
Sbjct: 1801 GTSLLTLRATDPDVGANGQVTYGGVSS------ESFSLDPDTGVLTTLRALDREEQEEIN 1854
Query: 1331 VIVRAERQKYSRELPHMIYPVA 1352
+ V A+ + +L H+ VA
Sbjct: 1855 LTVYAQDRGSPPQLTHVTVRVA 1876
Score = 64.9 bits (151), Expect = 2e-09
Identities = 74/319 (23%), Positives = 132/319 (41%), Gaps = 27/319 (8%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIA---PIGPSLTIPLTV 134
+A +S V++ D NDN P+F +P V + E P G A + ++A +G + + +
Sbjct: 1663 AARVSARVFVTDENDNAPVFA-SPSRVRLPEDQPPGPAA-LHVVARDPDLGEAARVSYRL 1720
Query: 135 PRG----LTIFKDIRAFDRDKP-NTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLD 189
G + A +P + H V +D G ++ + + V D
Sbjct: 1721 ASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVND 1780
Query: 190 YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSV 249
++ + ++ L + A D D+G + Y +S FSLD
Sbjct: 1781 EAPTFQQQEYSVLLRENNPPGTSLLT--LRATDPDVGANGQVTYGGVSSES---FSLDPD 1835
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
G L + LD + + + L V A +P + V + + D ND+ P F
Sbjct: 1836 TGVLTTLRALDREEQEEIN-----LTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSA 1890
Query: 310 FYNISIVENL-PNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQ 366
++ + E P ++L+ A+D D G NG+ Y++ DP GAF +D SG
Sbjct: 1891 HLSLEVPEGQDPQTLTMLR--ASDPDVGANGQLQYRILDGDPSGAFVLDLASG--EFGTM 1946
Query: 367 TVLDREAHSSLRMKVYAKE 385
LDRE + ++++ A++
Sbjct: 1947 RPLDREVEPAFQLRIEARD 1965
Score = 63.3 bits (147), Expect = 6e-09
Identities = 84/326 (25%), Positives = 131/326 (40%), Gaps = 23/326 (7%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI----APIGPSL 128
G +SA L +TV + D ND+ P F Y V V E P G A +
Sbjct: 1967 GQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHV 2026
Query: 129 TIPLTV-PRGLTIFK----DIR-AFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVL 182
T L G + + ++R A D+ P+ S V G G L ++ +
Sbjct: 2027 TYYLGAGTAGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAG--PLSTTVSVTI 2084
Query: 183 LLRKVLDYDAG--DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND 240
+R V D+ +L + G L + A D+D G A++ Y L +G
Sbjct: 2085 TVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRL-AGTP 2143
Query: 241 RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLN 300
++DS G + + + + L VL + A+ L P ++A + + L
Sbjct: 2144 PPGTTVDSYTGEIRVAR-----SPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEA 2198
Query: 301 DNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRS 358
+ P F +I EN P G ++ A G NG TY + + KG FSI P +
Sbjct: 2199 ERGPRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPST 2257
Query: 359 GWLTVRNQTVLDREAHSSLRMKVYAK 384
G +TVR+ LD E LR+ + A+
Sbjct: 2258 GAITVRSAEGLDFEVSPRLRLVLQAE 2283
Score = 62.9 bits (146), Expect = 9e-09
Identities = 58/202 (28%), Positives = 94/202 (46%), Gaps = 24/202 (11%)
Query: 936 PLFL-IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVI 994
P FL + EN P GT++ ++ A D DSG NG++ Y +LS D+ + F I
Sbjct: 1245 PTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSL--------QQLSEDS----KAFRI 1292
Query: 995 NERHGHVIVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKT-- 1048
+ + G V ++L E S ++L + DGG+ + +V V V D+ND+ P F +
Sbjct: 1293 HPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASG 1352
Query: 1049 ----WYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSV 1104
V + ++ + A D D G+N + Y + ++L F + P +G L
Sbjct: 1353 AAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSEL-FSLHPHSGELLT 1411
Query: 1105 NGELDRETEDKYILTVVARDNG 1126
L R Y+LT+ A D G
Sbjct: 1412 AAPLIRAERPHYVLTLSAHDQG 1433
Score = 61.7 bits (143), Expect = 2e-08
Identities = 49/179 (27%), Positives = 80/179 (44%), Gaps = 15/179 (8%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D GV + + + L++G F++D G + L + L L+++
Sbjct: 1052 LRALDPDSGVNSRVTFTLLAGGGGA-FTVDPTTGHVRLMRPLGPSG-----GPAHELELE 1105
Query: 278 ASQLNNPLKTAQARVEIELLDLNDN--LPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
A +P +T+ R+ + + D+ P F Y + + G VLQV A D
Sbjct: 1106 ARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPD- 1164
Query: 336 GENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVG 392
G TY L + F ++P+SGWL VR LDREA +KV A + + +G
Sbjct: 1165 --GGPITYHLAAEGASSPFGLEPQSGWLWVR--AALDREAQELYILKVMAVSGSKAELG 1219
Score = 60.9 bits (141), Expect = 3e-08
Identities = 45/132 (34%), Positives = 63/132 (47%), Gaps = 6/132 (4%)
Query: 229 ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTA 288
A + L G+ R LFSLD+V+G L + LD + L L+V+A P A
Sbjct: 958 APVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRE----LLGPVLELEVRAGS-GVPPAFA 1012
Query: 289 QARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ-LDD 347
ARV + L D+NDN P F + + N G + + A D D G N T+ L
Sbjct: 1013 VARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAG 1072
Query: 348 PKGAFSIDPRSG 359
GAF++DP +G
Sbjct: 1073 GGGAFTVDPTTG 1084
Score = 60.1 bits (139), Expect = 6e-08
Identities = 39/117 (33%), Positives = 58/117 (49%), Gaps = 4/117 (3%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D+D G + Y L S D FS+D NG+LF A VL+
Sbjct: 2534 VSATDRDSGANGHISYHLASPADG--FSVDPNNGTLFTIVGTVALGHDGSGAVDVVLE-- 2589
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
A P + A+A V ++L D ND+ P F + Y +++ E+LP G ++L + ATD D
Sbjct: 2590 ARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDAD 2646
Score = 59.3 bits (137), Expect = 1e-07
Identities = 53/171 (30%), Positives = 85/171 (49%), Gaps = 13/171 (7%)
Query: 220 AIDQDLGVGATLRYELISGNDRK-LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQA 278
A + GVGA L Y L+ G D + F+LD+ +G L+L + LD +A +A L V+A
Sbjct: 1491 AAPEPAGVGA-LTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRA----LTVRA 1545
Query: 279 SQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD-QGE 337
RV++++ D N++ P F D +++ EN G ++ A+D D G
Sbjct: 1546 EGPGGA-GARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGP 1604
Query: 338 NGEFTYQL---DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N + Y+L + P A +D R+G L+ LDRE +L + V A +
Sbjct: 1605 NSDVRYRLLRQEPPVPALRLDARTGALSAPRG--LDRETTPALLLLVEATD 1653
Score = 58.8 bits (136), Expect = 1e-07
Identities = 53/173 (30%), Positives = 85/173 (49%), Gaps = 13/173 (7%)
Query: 218 IHAIDQDLGVGATLRYELISG---NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
+ A D D G L Y L +G + F +D+ +G + + LD D ++F
Sbjct: 736 VTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQG----PSSFDF 791
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
V A LK+ V++ L D NDN P+F Y SI P G +VL++ A D D
Sbjct: 792 TVTAVD-GGGLKS-MVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPD 849
Query: 335 QGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
QG +G +Y + + F++D +SG LTV L R A+S +++++ A++
Sbjct: 850 QGSHGRLSYHILAGNSPPLFTLDEQSGLLTV--AWPLARRANSVVQLEIGAED 900
Score = 58.8 bits (136), Expect = 1e-07
Identities = 44/152 (28%), Positives = 70/152 (46%), Gaps = 23/152 (15%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PE++P GT +++L A D D+G NG + Y Y+ A F++ G
Sbjct: 2000 VPEDVPAGTLLLQLQAHDPDAGANGHVTY------YLGAGTAGA--------FLLEPSSG 2045
Query: 1000 HVIVARSLPPES--EFRLNISALDG---GNLNDNISVRVFVKDVNDHFPVFKKTWYNFNV 1054
+ A +L E + ++SA+DG G L+ +SV + V+DVNDH P F + +
Sbjct: 2046 ELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRL 2105
Query: 1055 EEA----QYTRRVLGKVDATDADFGQNANLTY 1082
L + A D D G NA++ Y
Sbjct: 2106 PRPGPSFSTPTLALATLRAEDRDAGANASILY 2137
Score = 58.0 bits (134), Expect = 2e-07
Identities = 60/220 (27%), Positives = 97/220 (44%), Gaps = 27/220 (12%)
Query: 921 VKPKNKFALDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
V P LDV+ P+F +PE+ P+G ++ + A D D G +G +R+ +S
Sbjct: 2721 VVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSG 2780
Query: 974 VYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFR--LNISALDGGNLNDNIS- 1030
PS L F ++E G + +A +L E++ R L + A D + ++
Sbjct: 2781 ---DPSGL----------FELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAP 2827
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS--- 1087
V + V+DVNDH P F + +V E Q ++ + A D D G L Y + +
Sbjct: 2828 VTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPG 2887
Query: 1088 -DTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+ F ++ TG L D E + + L V A D G
Sbjct: 2888 PEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAG 2927
Score = 57.2 bits (132), Expect = 4e-07
Identities = 87/318 (27%), Positives = 128/318 (40%), Gaps = 22/318 (6%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP--- 123
+V GL +++ +V+V ++DVNDN P F T Y+ ++ E T G F+ + A
Sbjct: 684 VVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGT-CFLQVTATDAD 742
Query: 124 IGPSLTIPLTVPRGLTIFKD----IRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHK 179
GP + ++ GL I A D T D S D A++
Sbjct: 743 SGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQG-PSSFDFTVTAVDGGGL 801
Query: 180 PVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPI---HAIDQDLGVGATLRYELI 236
++ KV D D Q I + + A D D G L Y ++
Sbjct: 802 KSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHIL 861
Query: 237 SGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
+GN LF+LD +G L + L A +Q L++ A ARV+I +
Sbjct: 862 AGNSPPLFTLDEQSGLLTVAWPLARRANSVVQ-----LEIGAEDGGGLQAEPSARVDISI 916
Query: 297 LDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD--DPKGAFSI 354
+ P FE Y S+ E++ G SV V A + G T L DP+G FS+
Sbjct: 917 VPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPP-GRLAPVTLSLSGGDPRGLFSL 975
Query: 355 DPRSGWLTVRNQTVLDRE 372
D SG L + LDRE
Sbjct: 976 DAVSGLL--QTLRPLDRE 991
Score = 56.0 bits (129), Expect = 1e-06
Identities = 61/213 (28%), Positives = 89/213 (41%), Gaps = 19/213 (8%)
Query: 945 PIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVA 1004
P GT +++L A D D G +G++ Y + PP F ++E+ G + VA
Sbjct: 835 PPGTAVLRLRAHDPDQGSHGRLSYHILAG-NSPP------------LFTLDEQSGLLTVA 881
Query: 1005 RSLP--PESEFRLNISALDGGNLNDNISVRVFVKDV--NDHFPVFKKTWYNFNVEEAQYT 1060
L S +L I A DGG L S RV + V P+F++ Y F+V E
Sbjct: 882 WPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAP 941
Query: 1061 RRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTV 1120
+G V A + G+ A +T + D F + ++G+L LDRE +L +
Sbjct: 942 GTSVGIVQAHNPP-GRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGP-VLEL 999
Query: 1121 VARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYA 1153
R DVNDNSP F A
Sbjct: 1000 EVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPA 1032
Score = 54.4 bits (125), Expect = 3e-06
Identities = 70/275 (25%), Positives = 104/275 (37%), Gaps = 25/275 (9%)
Query: 892 EFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTII 951
+F Q + + + G A T++ V+ N A Q ++ E+ P G+ I+
Sbjct: 2474 DFEQCDRYQLQLLAHDGPHEGRANLTVL-VEDVNDNAPAFSQSLYQVMLLEHTPPGSAIL 2532
Query: 952 KLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPES 1011
++A D DSG NG I Y S P S D + ++ G V +
Sbjct: 2533 SVSATDRDSGANGHISYHLAS----PADGFSVDPNNGTLFTIV----GTVALGHDGSGAV 2584
Query: 1012 EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATD 1071
+ L +V V ++D NDH P F + Y V E L ++ATD
Sbjct: 2585 DVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATD 2644
Query: 1072 ADFGQ-NANLTYFIQPSDTDLPFEISP--------------LTGVLSVNGELDRETEDKY 1116
AD + +A + Y I + F++ P G L + LD E+ +Y
Sbjct: 2645 ADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQY 2704
Query: 1117 ILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
LTV A D G DVNDN P F
Sbjct: 2705 NLTVAAADRG-QPPQSSVVPVTVTVLDVNDNPPVF 2738
Score = 53.2 bits (122), Expect = 7e-06
Identities = 47/176 (26%), Positives = 74/176 (42%), Gaps = 12/176 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRK--LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A D D GV + YE+ FS+D+ G L LE+ LD + Q L
Sbjct: 413 VFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFE-----QRRVHELV 467
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNIS----IVENLPNGFSVLQVMAT 331
VQA + A V + + D NDN P V F + + E P G V ++ +
Sbjct: 468 VQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVS 527
Query: 332 DKDQGENGEFTYQLDDPKGAFSIDPRSGWL-TVRNQTVLDREAHSSLRMKVYAKET 386
D D G+ L+ +G F++ + + V LDRE + ++V A ++
Sbjct: 528 DPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDS 583
Score = 51.2 bits (117), Expect = 3e-05
Identities = 94/424 (22%), Positives = 156/424 (36%), Gaps = 33/424 (7%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V L D ND+ P F S+ Y ++ + G+ + ++A D D G D S
Sbjct: 2604 VHVQLQDQNDHAPSFTLSH-YRVAVTEDLPPGSTLLTLEATDAD-GSRSHAAVDYSIISG 2661
Query: 505 LTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPAN-PSERRYSLAVVT------- 556
F++ P + P G AL +P + S +Y+L V
Sbjct: 2662 -NWGRVFQLEPRLAEAGESAGP---GPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPP 2717
Query: 557 ----IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDL 610
+ VT + P F A Y V + +G + + +DA V + +
Sbjct: 2718 QSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTV 2777
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
G G+ F ++E SG + + L + + A + T+ V DVN
Sbjct: 2778 SSGDPSGL-FELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVN 2836
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ-QDVTDD 729
D S V EN + H G L A + +
Sbjct: 2837 DHGPAFPLNLLST---SVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREA 2893
Query: 730 IAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
A+ + G + + P D E + +R+ V A + G +S + V + EDE D PVF
Sbjct: 2894 FALNSSTGELRARVPFDYEHTESFRLLVGAA-DAGNLSASVTVSVLVTGEDEYD--PVFL 2950
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ + E ++ G + ++ATD D G + L +Y+L F +++ TG +
Sbjct: 2951 APAFHFQVPEGARRGHSL---GHVQATDEDGGADGLVLYSL-ATSSPYFGINQTTGALYL 3006
Query: 849 IGDS 852
DS
Sbjct: 3007 RVDS 3010
Score = 43.6 bits (98), Expect = 0.006
Identities = 35/143 (24%), Positives = 60/143 (41%), Gaps = 7/143 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGND-RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D D G G + Y L + R LF +D G++ LD + + A T ++ +
Sbjct: 2329 VEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDRE----IWAETRLV-L 2383
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A+ +P A + + ++D NDN P + + + E+ G + QV D D G
Sbjct: 2384 MATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSG 2442
Query: 337 ENGEFTYQLDDPKGAFSIDPRSG 359
+ P+ FS+ G
Sbjct: 2443 PVLWYVLSPSGPQDPFSVGRYGG 2465
Score = 41.9 bits (94), Expect = 0.017
Identities = 88/383 (22%), Positives = 141/383 (36%), Gaps = 42/383 (10%)
Query: 1051 NFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTDLPFEISPLTGVLSVNGE 1107
+ ++E Q ++G + A G A L YFI + S I +GV+
Sbjct: 184 DLQIDEEQPAGTLIGDISA-GLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARV 242
Query: 1108 LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADE 1167
LDRE D+Y T V D D+ND++P F L+ A
Sbjct: 243 LDREQRDRYRFTAVTPDG-------ATVEVTVRVADINDHAPAFPQARAALQVPEHTAFG 295
Query: 1168 LSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGN---GLILYSLPQRKNQ 1224
+ + E + + A G + F +T +G L++ R+N+
Sbjct: 296 -TRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENR 354
Query: 1225 QNL---------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV--NAP 1273
+ G P + A+L VT+ D+ D P F Y + E++ +P
Sbjct: 355 SHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHA-----PAFNQSRYHAVVSESLAPGSP 409
Query: 1274 VELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIV 1333
V V + + N + Y I N ++ F ID G L L R D E + +E++V
Sbjct: 410 VLQVFASDADAGVNGAVTYEI-NRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVV 468
Query: 1334 RAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRP--LVTAI 1391
+A EL V V + V+ + D SP+ + P LV I
Sbjct: 469 QARDGGAHPELGSAF--VTVHVRDANDNQPSMTVIFLS--ADGSPQVSEAAPPGQLVARI 524
Query: 1392 PTTAP----FGYQVMQLKGAIGH 1410
+ P F + + L+G GH
Sbjct: 525 SVSDPDDGDFAHVNVSLEGGEGH 547
Score = 41.9 bits (94), Expect = 0.017
Identities = 27/82 (32%), Positives = 43/82 (52%), Gaps = 6/82 (7%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L + V V V + ++ +PVF+ + + F + A+ G +G V+A D D G +G+VLY
Sbjct: 2929 LSASVTVSVLVTGEDEYDPVFL-APAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYS 2987
Query: 499 LQRTSNLTITSPFKINPNTGTV 520
L +S F IN TG +
Sbjct: 2988 LATSSPY-----FGINQTTGAL 3004
Score = 41.1 bits (92), Expect = 0.030
Identities = 44/162 (27%), Positives = 66/162 (40%), Gaps = 7/162 (4%)
Query: 226 GVGATLRYELISGNDR-KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNP 284
G + +RY L+ LD+ G+L + LD + L A+
Sbjct: 1603 GPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRR 1662
Query: 285 LKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQ 344
ARV + D NDN P F + + E+ P G + L V+A D D GE +Y+
Sbjct: 1663 AARVSARVFVT--DENDNAPVFASPS-RVRLPEDQPPGPAALHVVARDPDLGEAARVSYR 1719
Query: 345 L-DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
L G F + +G L+V LDRE + + V A +
Sbjct: 1720 LASGGDGHFRLHSSTGALSVVRP--LDREQRAEHVLTVVASD 1759
Score = 36.3 bits (80), Expect = 0.85
Identities = 16/32 (50%), Positives = 21/32 (65%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
++TV +EDVNDN P F + Y V + E TP G
Sbjct: 2497 NLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPG 2528
Score = 35.9 bits (79), Expect = 1.1
Identities = 28/90 (31%), Positives = 44/90 (48%), Gaps = 9/90 (10%)
Query: 820 GTNALFMYTLFG-EGKEM---FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSS 875
GT A MY + EG + +DE++GVV+ LDRE++ Y+ + V D +
Sbjct: 207 GTAAPLMYFISAQEGSGVGTDLAIDEHSGVVR-TARVLDREQRDRYRFTAVTPD----GA 261
Query: 876 EAELIIMIGDENDNKPEFNQIEENSKVRIH 905
E+ + + D ND+ P F Q +V H
Sbjct: 262 TVEVTVRVADINDHAPAFPQARAALQVPEH 291
Score = 34.3 bits (75), Expect = 3.4
Identities = 17/43 (39%), Positives = 23/43 (53%)
Query: 1440 QATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARD 1482
QA D D G N + Y + A F ++P SG +R AAL R+
Sbjct: 2014 QAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAALDRE 2056
Score = 33.5 bits (73), Expect = 6.0
Identities = 23/79 (29%), Positives = 31/79 (39%), Gaps = 6/79 (7%)
Query: 1075 GQNANLTYFIQPSDTDLPFEISPLTGVLSVNGE--LDRETEDKYILTVVARDNGXXXXXX 1132
G N +TY I + F I P TG ++V LD E + L + A G
Sbjct: 2233 GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGG----AF 2288
Query: 1133 XXXXXXXXXXDVNDNSPKF 1151
D NDN+P+F
Sbjct: 2289 AFTVLTLTLQDANDNAPRF 2307
Score = 33.1 bits (72), Expect = 7.9
Identities = 14/45 (31%), Positives = 24/45 (53%)
Query: 1440 QATDSDIGINADIRYQILNEQAPRFAIDPVSGTVRVVAALARDAG 1484
+A D D G+N+ + + +L F +DP +G VR++ L G
Sbjct: 1053 RALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGG 1097
>AF152507-1|AAD43768.1| 823|Homo sapiens protocadherin gamma A1
short form protein protein.
Length = 823
Score = 117 bits (281), Expect = 4e-25
Identities = 127/473 (26%), Positives = 199/473 (42%), Gaps = 39/473 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E M VEV ++D NDN P F L EF M GT + D D+G N +
Sbjct: 111 EDKMKLFPVEVEIIDINDNTPQFQLEEL-EFKMNEITTPGTRVSLPFGQDLDVGMNSLQS 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASD--QPANPSERRYS 551
Y L + ++ + V +SP+ E H L + ASD +P R
Sbjct: 170 YQLSSNPHFSLDVQQGADGPQHPEMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIY 229
Query: 552 LAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYD 609
+ VV + P P F A Y V NV +GT + + D E +V+Y
Sbjct: 230 IQVV-------DANDNP--PAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVTYS 280
Query: 610 LLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
H + V F ++ +G I+ + L MY E V Q+ A L + V+
Sbjct: 281 -FHNVDHRVAQIFRLDSYTGEISNKEPLDFEEYKMYSME-VQAQDGAGLMAKVKVLIKVL 338
Query: 668 DVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVT 727
DVND + + + V EN I + + NG F+ N
Sbjct: 339 DVNDNAPEV---TITSVTTAVPENFPPGTIIALISVHDQDSGDNGY-TTCFIPGNLPFKL 394
Query: 728 DDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVF 787
+ + + + T++ LDRE Y +T+ A ++G + + +++ + D NDN PVF
Sbjct: 395 EKL-VDNYYRLVTERTLDRELISGYNITITA-IDQGTPALSTETHISLLVTDINDNSPVF 452
Query: 788 EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEM---FDVDE 841
+Y +I EN+ G I ++A D D NA Y+L +G + ++
Sbjct: 453 HQDSYSAYIPENNPRGASIFS---VRAHDLDSNENAQITYSLIEDTIQGAPLSAYLSINS 509
Query: 842 NTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
+TGV+ + S D E+ +L ++ARD+G LSS L + + D+NDN PE
Sbjct: 510 DTGVL-YALRSFDYEQFRDMQLKVMARDSGDPPLSSNVSLSLFLLDQNDNAPE 561
Score = 81.8 bits (193), Expect = 2e-14
Identities = 81/284 (28%), Positives = 116/284 (40%), Gaps = 48/284 (16%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN+P+GT ++ +NA D D G NG++ Y F++ + V + F ++ G
Sbjct: 251 VPENVPLGTQLLMVNATDPDEGANGEVTYSFHNVDH-----------RVAQIFRLDSYTG 299
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ L E + + + A DG L + V + V DVND+ P T V E
Sbjct: 300 EISNKEPLDFEEYKMYSMEVQAQDGAGLMAKVKVLIKVLDVNDNAPEVTITSVTTAVPEN 359
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
++ + D D G N T FI P +LPF++ L L LDRE
Sbjct: 360 FPPGTIIALISVHDQDSGDNGYTTCFI-PG--NLPFKLEKLVDNYYRLVTERTLDRELIS 416
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFE 1174
Y +T+ A D G D+NDNSP F H ++
Sbjct: 417 GYNITITAIDQG-TPALSTETHISLLVTDINDNSPVF----------HQDS--------- 456
Query: 1175 SVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSL 1218
Y A I EN P G ++ V A+D D N N I YSL
Sbjct: 457 -------YSAYIPENNPRGASIFSVRAHDLD--SNENAQITYSL 491
Score = 79.8 bits (188), Expect = 7e-14
Identities = 107/476 (22%), Positives = 198/476 (41%), Gaps = 35/476 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
+ + + ++DANDN P F + Y ++ N +GT + V A DPD G NG V Y
Sbjct: 226 LRIYIQVVDANDNPPAFTQAQ-YHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNV 284
Query: 503 SNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
+ + F+++ TG +S E E +E Q + + + ++V
Sbjct: 285 DH-RVAQIFRLDSYTGEISNKEPLDFEEYKMYSMEVQAQDGAGLMAKVKVLIKVLDV--- 340
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAV 622
N P++ V N GT + I V+D + D Y +PF +
Sbjct: 341 -NDNAPEVTI---TSVTTAVPENFPPGTIIALISVHDQ-DSGDNGYTTCF-IPGNLPFKL 394
Query: 623 EER-SGVITVVDD--LSRYNRPMYDFEAVAL-QENANLSIVTNATVHVVDVNDERGVLLK 678
E+ +V + L R Y+ A+ Q LS T+ ++ V D+ND V +
Sbjct: 395 EKLVDNYYRLVTERTLDRELISGYNITITAIDQGTPALSTETHISLLVTDINDNSPVFHQ 454
Query: 679 GAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ----QDVTDDIAIAE 734
++S ++ EN+ A IF + N + + + ++ ++I
Sbjct: 455 DSYSA---YIPENNPRGA--SIFSVRAHDLDSNENAQITYSLIEDTIQGAPLSAYLSINS 509
Query: 735 D-GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP--VFEHAT 791
D G ++ + D E+ ++ V+A + G + +++++ D+NDN P ++
Sbjct: 510 DTGVLYALRSFDYEQFRDMQLKVMAR-DSGDPPLSSNVSLSLFLLDQNDNAPEILYPALP 568
Query: 792 YEGFI-MENSKIGTEI-KMDNIIKATDADEGTNALFMYTLFGEGKE-MFDVDENTGVVKF 848
+G +E + + E + + A D D G NA Y L + +F V +TG V+
Sbjct: 569 TDGSTGVELAPLSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRT 628
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDE-NDNKPEFNQIEENSK 901
LDR+ + L + +D G LS+ L + + D +D + +E ++K
Sbjct: 629 ARALLDRD-ALKQSLVVAVQDHGQPPLSATVTLTVAVADRISDILADLGSLEPSAK 683
Score = 74.9 bits (176), Expect = 2e-12
Identities = 52/168 (30%), Positives = 84/168 (50%), Gaps = 7/168 (4%)
Query: 222 DQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQL 281
D D+G+ + Y+L S L +G E L + +A ++ + AS
Sbjct: 159 DLDVGMNSLQSYQLSSNPHFSLDVQQGADGPQHPEMVLQSPLDREEEAVHHLI-LTASDG 217
Query: 282 NNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEF 341
P+++ R+ I+++D NDN P F Y+I++ EN+P G +L V ATD D+G NGE
Sbjct: 218 GEPVRSGTLRIYIQVVDANDNPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEV 277
Query: 342 TYQLD--DPKGA--FSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TY D + A F +D +G + N+ LD E + M+V A++
Sbjct: 278 TYSFHNVDHRVAQIFRLDSYTG--EISNKEPLDFEEYKMYSMEVQAQD 323
Score = 67.7 bits (158), Expect = 3e-10
Identities = 92/334 (27%), Positives = 139/334 (41%), Gaps = 44/334 (13%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVP-- 135
S L + + + D NDN P F YH+ V E P G + + +T
Sbjct: 223 SGTLRIYIQVVDANDNPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFH 282
Query: 136 ----RGLTIFKDIRAFDRDKPNTPNSDVH----YSIVSGNDDGHFALESSHKPVLLLRKV 187
R IF+ + ++ + N D YS+ DG + V +L KV
Sbjct: 283 NVDHRVAQIFR-LDSYTGEISNKEPLDFEEYKMYSMEVQAQDGAGLMAK----VKVLIKV 337
Query: 188 LDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGV-GATLRYELISGNDRK 242
LD + E V + S E P I A+ DQD G G T + I GN
Sbjct: 338 LDVNDNAPE---VTITSVTTAVPENFPPGTIIALISVHDQDSGDNGYTTCF--IPGN--L 390
Query: 243 LFSLDSVNGSLF-LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLND 301
F L+ + + + L E LD E + + + + A P + + + + + D+ND
Sbjct: 391 PFKLEKLVDNYYRLVTERTLDRE---LISGYNITITAIDQGTPALSTETHISLLVTDIND 447
Query: 302 NLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSG 359
N P F D Y+ I EN P G S+ V A D D EN + TY L D +GA P S
Sbjct: 448 NSPVFHQDSYSAYIPENNPRGASIFSVRAHDLDSNENAQITYSLIEDTIQGA----PLSA 503
Query: 360 WLTVRNQT-VL------DREAHSSLRMKVYAKET 386
+L++ + T VL D E +++KV A+++
Sbjct: 504 YLSINSDTGVLYALRSFDYEQFRDMQLKVMARDS 537
Score = 67.3 bits (157), Expect = 4e-10
Identities = 70/240 (29%), Positives = 102/240 (42%), Gaps = 19/240 (7%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
+I+V N A +V +PEN P GT I ++ D DSG NG +
Sbjct: 334 LIKVLDVNDNAPEVTITSVTTAVPENFPPGTIIALISVHDQDSGDNGYTTCFIPGNL--- 390
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFV 1035
P KL + L Y ++ ER + R L S + + I+A+D G L+ + + V
Sbjct: 391 PFKL--EKLVDNYYRLVTER----TLDRELI--SGYNITITAIDQGTPALSTETHISLLV 442
Query: 1036 KDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-----FIQPSDTD 1090
D+ND+ PVF + Y+ + E + V A D D +NA +TY IQ +
Sbjct: 443 TDINDNSPVFHQDSYSAYIPENNPRGASIFSVRAHDLDSNENAQITYSLIEDTIQGAPLS 502
Query: 1091 LPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
I+ TGVL D E L V+ARD+G D NDN+P+
Sbjct: 503 AYLSINSDTGVLYALRSFDYEQFRDMQLKVMARDSG-DPPLSSNVSLSLFLLDQNDNAPE 561
Score = 65.7 bits (153), Expect = 1e-09
Identities = 66/199 (33%), Positives = 93/199 (46%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P G +I + A DLDS N QI Y + I + LSA Y IN G
Sbjct: 461 IPENNPRGASIFSVRAHDLDSNENAQITYSLIEDT-IQGAPLSA-------YLSINSDTG 512
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK----KTWYN 1051
+ RS E + +L + A D G+ L+ N+S+ +F+ D ND+ P T +
Sbjct: 513 VLYALRSFDYEQFRDMQLKVMARDSGDPPLSSNVSLSLFLLDQNDNAPEILYPALPTDGS 572
Query: 1052 FNVEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG-VLSVNGE 1107
VE A + ++ KV A D D GQNA L+Y + + F + TG V +
Sbjct: 573 TGVELAPLSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAL 632
Query: 1108 LDRETEDKYILTVVARDNG 1126
LDR+ K L V +D+G
Sbjct: 633 LDRDAL-KQSLVVAVQDHG 650
Score = 62.1 bits (144), Expect = 1e-08
Identities = 58/210 (27%), Positives = 92/210 (43%), Gaps = 18/210 (8%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
GT + DLD G+N Y+ +S + +L+V++ +H +++
Sbjct: 149 GTRVSLPFGQDLDVGMNSLQSYQLSSNPHF--------SLDVQQG-ADGPQHPEMVLQSP 199
Query: 1007 LPPESE--FRLNISALDGGNLNDNISVRVFVK--DVNDHFPVFKKTWYNFNVEEAQYTRR 1062
L E E L ++A DGG + ++R++++ D ND+ P F + Y+ NV E
Sbjct: 200 LDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHINVPENVPLGT 259
Query: 1063 VLGKVDATDADFGQNANLTYFIQPSDTDLP--FEISPLTGVLSVNGELDRETEDKYILTV 1120
L V+ATD D G N +TY D + F + TG +S LD E Y + V
Sbjct: 260 QLLMVNATDPDEGANGEVTYSFHNVDHRVAQIFRLDSYTGEISNKEPLDFEEYKMYSMEV 319
Query: 1121 VARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
A+D DVNDN+P+
Sbjct: 320 QAQDG---AGLMAKVKVLIKVLDVNDNAPE 346
Score = 61.7 bits (143), Expect = 2e-08
Identities = 49/173 (28%), Positives = 75/173 (43%), Gaps = 9/173 (5%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G++ T + +DRE+ M + FN V ++ V + I D NDN P F+ E
Sbjct: 82 GSLITARRIDREELCAQSMPCLVSFNILVEDKMKLFPVEVEIIDINDNTPQFQLEELEFK 141
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVK----FIGD 851
+ E + GT + + D D G N+L Y L DV + + +
Sbjct: 142 MNEITTPGTRVSLP---FGQDLDVGMNSLQSYQLSSNPHFSLDVQQGADGPQHPEMVLQS 198
Query: 852 SLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKV 902
LDRE++ ++ L L A D G S + I + D NDN P F Q + + V
Sbjct: 199 PLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHINV 251
Score = 58.4 bits (135), Expect = 2e-07
Identities = 45/179 (25%), Positives = 84/179 (46%), Gaps = 11/179 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR--KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
++A D D G + Y + + R ++F LDS G + ++ LD + E+ + + ++
Sbjct: 264 VNATDPDEGANGEVTYSFHNVDHRVAQIFRLDSYTGEISNKEPLDFE-EYKM----YSME 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
VQA + A+ +V I++LD+NDN PE + ++ EN P G + + D+D
Sbjct: 319 VQAQDGAGLM--AKVKVLIKVLDVNDNAPEVTITSVTTAVPENFPPGTIIALISVHDQDS 376
Query: 336 GENGEFTYQLDDPKGAFSIDPR-SGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
G+NG +T F ++ + + + LDRE S + + A + + T
Sbjct: 377 GDNG-YTTCFIPGNLPFKLEKLVDNYYRLVTERTLDRELISGYNITITAIDQGTPALST 434
Score = 46.8 bits (106), Expect = 6e-04
Identities = 46/170 (27%), Positives = 77/170 (45%), Gaps = 20/170 (11%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR-----KLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A D D A + Y LI + S++S G L+ + D + ++Q
Sbjct: 474 VRAHDLDSNENAQITYSLIEDTIQGAPLSAYLSINSDTGVLYALRSFDYEQFRDMQ---- 529
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLP----NGFSV 325
L+V A +P ++ + + LLD NDN PE + + VE P G+ V
Sbjct: 530 -LKVMARDSGDPPLSSNVSLSLFLLDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLV 588
Query: 326 LQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREA 373
+V+A D+D G+N +Y+L G FS+ +G + + +LDR+A
Sbjct: 589 TKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTA-RALLDRDA 637
Score = 46.4 bits (105), Expect = 8e-04
Identities = 36/125 (28%), Positives = 58/125 (46%), Gaps = 5/125 (4%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
++S LF+L+ +GSL + +D + L A + V + L K VE+
Sbjct: 66 IVSRGRMPLFALNPRSGSLITARRIDRE---ELCAQSMPCLVSFNILVED-KMKLFPVEV 121
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
E++D+NDN P+F+++ + E G V D D G N +YQL FS+
Sbjct: 122 EIIDINDNTPQFQLEELEFKMNEITTPGTRVSLPFGQDLDVGMNSLQSYQLSS-NPHFSL 180
Query: 355 DPRSG 359
D + G
Sbjct: 181 DVQQG 185
Score = 43.6 bits (98), Expect = 0.006
Identities = 48/172 (27%), Positives = 77/172 (44%), Gaps = 27/172 (15%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN 1287
G P S T + + V D D + P F Y + + ENV +L+ +N T+ E
Sbjct: 218 GEPVRSGTLRIYIQVVDAND-----NPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEG 272
Query: 1288 FKMRY-YILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPH 1346
Y + D + + F +D G + ++E D +E E + YS E+
Sbjct: 273 ANGEVTYSFHNVDHRVAQIFRLDSYTGEI-----SNKEPLD-FE-----EYKMYSMEVQ- 320
Query: 1347 MIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFG 1398
A+D M K VKV++++ DVNDN+P+ T + + TA+P P G
Sbjct: 321 -----AQDGAGLMAK--VKVLIKVLDVNDNAPEVTITS--VTTAVPENFPPG 363
Score = 40.7 bits (91), Expect = 0.039
Identities = 38/131 (29%), Positives = 59/131 (45%), Gaps = 11/131 (8%)
Query: 436 DEQLMSFVNVEVTLLDANDNNP-VFVPSNLYEFS-----MKSNAKVGTVIGKVKAVDPDL 489
D L S V++ + LLD NDN P + P+ + S +A+ G ++ KV AVD D
Sbjct: 539 DPPLSSNVSLSLFLLDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLVTKVVAVDRDS 598
Query: 490 GQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSE 547
GQN + Y L + S + F + +TG V A + + + +L V D P
Sbjct: 599 GQNAWLSYRLLKASEPGL---FSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLS 655
Query: 548 RRYSLAVVTIE 558
+L V +
Sbjct: 656 ATVTLTVAVAD 666
Score = 40.3 bits (90), Expect = 0.052
Identities = 42/170 (24%), Positives = 65/170 (38%), Gaps = 12/170 (7%)
Query: 992 FVINERHGHVIVARSLPPESEFRLNISALDGGNL--NDNIS---VRVFVKDVNDHFPVFK 1046
F +N R G +I AR + E ++ L N+ D + V V + D+ND+ P F+
Sbjct: 75 FALNPRSGSLITARRIDREELCAQSMPCLVSFNILVEDKMKLFPVEVEIIDINDNTPQFQ 134
Query: 1047 KTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGV 1101
F + E + D D G N+ +Y + S+ ++ P
Sbjct: 135 LEELEFKMNEITTPGTRVSLPFGQDLDVGMNSLQSYQLS-SNPHFSLDVQQGADGPQHPE 193
Query: 1102 LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
+ + LDRE E + L + A D G D NDN P F
Sbjct: 194 MVLQSPLDREEEAVHHLILTASDGG-EPVRSGTLRIYIQVVDANDNPPAF 242
Score = 33.5 bits (73), Expect = 6.0
Identities = 17/75 (22%), Positives = 37/75 (49%), Gaps = 3/75 (4%)
Query: 1330 EVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVT 1389
E+++++ + + H+I A D E + +++ +++ D NDN P FT +
Sbjct: 193 EMVLQSPLDREEEAVHHLIL-TASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHI-- 249
Query: 1390 AIPTTAPFGYQVMQL 1404
+P P G Q++ +
Sbjct: 250 NVPENVPLGTQLLMV 264
Score = 33.5 bits (73), Expect = 6.0
Identities = 14/51 (27%), Positives = 23/51 (45%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
+ I G +S +++ + D+NDN P+F Y + E P G F
Sbjct: 422 ITAIDQGTPALSTETHISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIF 472
>AF152318-1|AAD43712.1| 931|Homo sapiens protocadherin gamma A1
protein.
Length = 931
Score = 117 bits (281), Expect = 4e-25
Identities = 127/473 (26%), Positives = 199/473 (42%), Gaps = 39/473 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E M VEV ++D NDN P F L EF M GT + D D+G N +
Sbjct: 111 EDKMKLFPVEVEIIDINDNTPQFQLEEL-EFKMNEITTPGTRVSLPFGQDLDVGMNSLQS 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASD--QPANPSERRYS 551
Y L + ++ + V +SP+ E H L + ASD +P R
Sbjct: 170 YQLSSNPHFSLDVQQGADGPQHPEMVLQSPLDREEEAVHHLILTASDGGEPVRSGTLRIY 229
Query: 552 LAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYD 609
+ VV + P P F A Y V NV +GT + + D E +V+Y
Sbjct: 230 IQVV-------DANDNP--PAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVTYS 280
Query: 610 LLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV 667
H + V F ++ +G I+ + L MY E V Q+ A L + V+
Sbjct: 281 -FHNVDHRVAQIFRLDSYTGEISNKEPLDFEEYKMYSME-VQAQDGAGLMAKVKVLIKVL 338
Query: 668 DVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVT 727
DVND + + + V EN I + + NG F+ N
Sbjct: 339 DVNDNAPEV---TITSVTTAVPENFPPGTIIALISVHDQDSGDNGY-TTCFIPGNLPFKL 394
Query: 728 DDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVF 787
+ + + + T++ LDRE Y +T+ A ++G + + +++ + D NDN PVF
Sbjct: 395 EKL-VDNYYRLVTERTLDRELISGYNITITA-IDQGTPALSTETHISLLVTDINDNSPVF 452
Query: 788 EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEM---FDVDE 841
+Y +I EN+ G I ++A D D NA Y+L +G + ++
Sbjct: 453 HQDSYSAYIPENNPRGASIFS---VRAHDLDSNENAQITYSLIEDTIQGAPLSAYLSINS 509
Query: 842 NTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
+TGV+ + S D E+ +L ++ARD+G LSS L + + D+NDN PE
Sbjct: 510 DTGVL-YALRSFDYEQFRDMQLKVMARDSGDPPLSSNVSLSLFLLDQNDNAPE 561
Score = 81.8 bits (193), Expect = 2e-14
Identities = 81/284 (28%), Positives = 116/284 (40%), Gaps = 48/284 (16%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN+P+GT ++ +NA D D G NG++ Y F++ + V + F ++ G
Sbjct: 251 VPENVPLGTQLLMVNATDPDEGANGEVTYSFHNVDH-----------RVAQIFRLDSYTG 299
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ L E + + + A DG L + V + V DVND+ P T V E
Sbjct: 300 EISNKEPLDFEEYKMYSMEVQAQDGAGLMAKVKVLIKVLDVNDNAPEVTITSVTTAVPEN 359
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
++ + D D G N T FI P +LPF++ L L LDRE
Sbjct: 360 FPPGTIIALISVHDQDSGDNGYTTCFI-PG--NLPFKLEKLVDNYYRLVTERTLDRELIS 416
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFE 1174
Y +T+ A D G D+NDNSP F H ++
Sbjct: 417 GYNITITAIDQG-TPALSTETHISLLVTDINDNSPVF----------HQDS--------- 456
Query: 1175 SVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSL 1218
Y A I EN P G ++ V A+D D N N I YSL
Sbjct: 457 -------YSAYIPENNPRGASIFSVRAHDLD--SNENAQITYSL 491
Score = 79.8 bits (188), Expect = 7e-14
Identities = 107/476 (22%), Positives = 198/476 (41%), Gaps = 35/476 (7%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
+ + + ++DANDN P F + Y ++ N +GT + V A DPD G NG V Y
Sbjct: 226 LRIYIQVVDANDNPPAFTQAQ-YHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFHNV 284
Query: 503 SNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
+ + F+++ TG +S E E +E Q + + + ++V
Sbjct: 285 DH-RVAQIFRLDSYTGEISNKEPLDFEEYKMYSMEVQAQDGAGLMAKVKVLIKVLDV--- 340
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAV 622
N P++ V N GT + I V+D + D Y +PF +
Sbjct: 341 -NDNAPEVTI---TSVTTAVPENFPPGTIIALISVHDQ-DSGDNGYTTCF-IPGNLPFKL 394
Query: 623 EER-SGVITVVDD--LSRYNRPMYDFEAVAL-QENANLSIVTNATVHVVDVNDERGVLLK 678
E+ +V + L R Y+ A+ Q LS T+ ++ V D+ND V +
Sbjct: 395 EKLVDNYYRLVTERTLDRELISGYNITITAIDQGTPALSTETHISLLVTDINDNSPVFHQ 454
Query: 679 GAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ----QDVTDDIAIAE 734
++S ++ EN+ A IF + N + + + ++ ++I
Sbjct: 455 DSYSA---YIPENNPRGA--SIFSVRAHDLDSNENAQITYSLIEDTIQGAPLSAYLSINS 509
Query: 735 D-GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP--VFEHAT 791
D G ++ + D E+ ++ V+A + G + +++++ D+NDN P ++
Sbjct: 510 DTGVLYALRSFDYEQFRDMQLKVMAR-DSGDPPLSSNVSLSLFLLDQNDNAPEILYPALP 568
Query: 792 YEGFI-MENSKIGTEI-KMDNIIKATDADEGTNALFMYTLFGEGKE-MFDVDENTGVVKF 848
+G +E + + E + + A D D G NA Y L + +F V +TG V+
Sbjct: 569 TDGSTGVELAPLSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRT 628
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDE-NDNKPEFNQIEENSK 901
LDR+ + L + +D G LS+ L + + D +D + +E ++K
Sbjct: 629 ARALLDRD-ALKQSLVVAVQDHGQPPLSATVTLTVAVADRISDILADLGSLEPSAK 683
Score = 74.9 bits (176), Expect = 2e-12
Identities = 52/168 (30%), Positives = 84/168 (50%), Gaps = 7/168 (4%)
Query: 222 DQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQL 281
D D+G+ + Y+L S L +G E L + +A ++ + AS
Sbjct: 159 DLDVGMNSLQSYQLSSNPHFSLDVQQGADGPQHPEMVLQSPLDREEEAVHHLI-LTASDG 217
Query: 282 NNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEF 341
P+++ R+ I+++D NDN P F Y+I++ EN+P G +L V ATD D+G NGE
Sbjct: 218 GEPVRSGTLRIYIQVVDANDNPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEV 277
Query: 342 TYQLD--DPKGA--FSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
TY D + A F +D +G + N+ LD E + M+V A++
Sbjct: 278 TYSFHNVDHRVAQIFRLDSYTG--EISNKEPLDFEEYKMYSMEVQAQD 323
Score = 67.7 bits (158), Expect = 3e-10
Identities = 92/334 (27%), Positives = 139/334 (41%), Gaps = 44/334 (13%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVP-- 135
S L + + + D NDN P F YH+ V E P G + + +T
Sbjct: 223 SGTLRIYIQVVDANDNPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEGANGEVTYSFH 282
Query: 136 ----RGLTIFKDIRAFDRDKPNTPNSDVH----YSIVSGNDDGHFALESSHKPVLLLRKV 187
R IF+ + ++ + N D YS+ DG + V +L KV
Sbjct: 283 NVDHRVAQIFR-LDSYTGEISNKEPLDFEEYKMYSMEVQAQDGAGLMAK----VKVLIKV 337
Query: 188 LDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGV-GATLRYELISGNDRK 242
LD + E V + S E P I A+ DQD G G T + I GN
Sbjct: 338 LDVNDNAPE---VTITSVTTAVPENFPPGTIIALISVHDQDSGDNGYTTCF--IPGN--L 390
Query: 243 LFSLDSVNGSLF-LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLND 301
F L+ + + + L E LD E + + + + A P + + + + + D+ND
Sbjct: 391 PFKLEKLVDNYYRLVTERTLDRE---LISGYNITITAIDQGTPALSTETHISLLVTDIND 447
Query: 302 NLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSG 359
N P F D Y+ I EN P G S+ V A D D EN + TY L D +GA P S
Sbjct: 448 NSPVFHQDSYSAYIPENNPRGASIFSVRAHDLDSNENAQITYSLIEDTIQGA----PLSA 503
Query: 360 WLTVRNQT-VL------DREAHSSLRMKVYAKET 386
+L++ + T VL D E +++KV A+++
Sbjct: 504 YLSINSDTGVLYALRSFDYEQFRDMQLKVMARDS 537
Score = 67.3 bits (157), Expect = 4e-10
Identities = 70/240 (29%), Positives = 102/240 (42%), Gaps = 19/240 (7%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
+I+V N A +V +PEN P GT I ++ D DSG NG +
Sbjct: 334 LIKVLDVNDNAPEVTITSVTTAVPENFPPGTIIALISVHDQDSGDNGYTTCFIPGNL--- 390
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFV 1035
P KL + L Y ++ ER + R L S + + I+A+D G L+ + + V
Sbjct: 391 PFKL--EKLVDNYYRLVTER----TLDRELI--SGYNITITAIDQGTPALSTETHISLLV 442
Query: 1036 KDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-----FIQPSDTD 1090
D+ND+ PVF + Y+ + E + V A D D +NA +TY IQ +
Sbjct: 443 TDINDNSPVFHQDSYSAYIPENNPRGASIFSVRAHDLDSNENAQITYSLIEDTIQGAPLS 502
Query: 1091 LPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
I+ TGVL D E L V+ARD+G D NDN+P+
Sbjct: 503 AYLSINSDTGVLYALRSFDYEQFRDMQLKVMARDSG-DPPLSSNVSLSLFLLDQNDNAPE 561
Score = 65.7 bits (153), Expect = 1e-09
Identities = 66/199 (33%), Positives = 93/199 (46%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P G +I + A DLDS N QI Y + I + LSA Y IN G
Sbjct: 461 IPENNPRGASIFSVRAHDLDSNENAQITYSLIEDT-IQGAPLSA-------YLSINSDTG 512
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK----KTWYN 1051
+ RS E + +L + A D G+ L+ N+S+ +F+ D ND+ P T +
Sbjct: 513 VLYALRSFDYEQFRDMQLKVMARDSGDPPLSSNVSLSLFLLDQNDNAPEILYPALPTDGS 572
Query: 1052 FNVEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG-VLSVNGE 1107
VE A + ++ KV A D D GQNA L+Y + + F + TG V +
Sbjct: 573 TGVELAPLSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAL 632
Query: 1108 LDRETEDKYILTVVARDNG 1126
LDR+ K L V +D+G
Sbjct: 633 LDRDAL-KQSLVVAVQDHG 650
Score = 62.1 bits (144), Expect = 1e-08
Identities = 58/210 (27%), Positives = 92/210 (43%), Gaps = 18/210 (8%)
Query: 947 GTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARS 1006
GT + DLD G+N Y+ +S + +L+V++ +H +++
Sbjct: 149 GTRVSLPFGQDLDVGMNSLQSYQLSSNPHF--------SLDVQQG-ADGPQHPEMVLQSP 199
Query: 1007 LPPESE--FRLNISALDGGNLNDNISVRVFVK--DVNDHFPVFKKTWYNFNVEEAQYTRR 1062
L E E L ++A DGG + ++R++++ D ND+ P F + Y+ NV E
Sbjct: 200 LDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHINVPENVPLGT 259
Query: 1063 VLGKVDATDADFGQNANLTYFIQPSDTDLP--FEISPLTGVLSVNGELDRETEDKYILTV 1120
L V+ATD D G N +TY D + F + TG +S LD E Y + V
Sbjct: 260 QLLMVNATDPDEGANGEVTYSFHNVDHRVAQIFRLDSYTGEISNKEPLDFEEYKMYSMEV 319
Query: 1121 VARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
A+D DVNDN+P+
Sbjct: 320 QAQDG---AGLMAKVKVLIKVLDVNDNAPE 346
Score = 61.7 bits (143), Expect = 2e-08
Identities = 49/173 (28%), Positives = 75/173 (43%), Gaps = 9/173 (5%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G++ T + +DRE+ M + FN V ++ V + I D NDN P F+ E
Sbjct: 82 GSLITARRIDREELCAQSMPCLVSFNILVEDKMKLFPVEVEIIDINDNTPQFQLEELEFK 141
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVK----FIGD 851
+ E + GT + + D D G N+L Y L DV + + +
Sbjct: 142 MNEITTPGTRVSLP---FGQDLDVGMNSLQSYQLSSNPHFSLDVQQGADGPQHPEMVLQS 198
Query: 852 SLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKV 902
LDRE++ ++ L L A D G S + I + D NDN P F Q + + V
Sbjct: 199 PLDREEEAVHHLILTASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHINV 251
Score = 58.4 bits (135), Expect = 2e-07
Identities = 45/179 (25%), Positives = 84/179 (46%), Gaps = 11/179 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR--KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
++A D D G + Y + + R ++F LDS G + ++ LD + E+ + + ++
Sbjct: 264 VNATDPDEGANGEVTYSFHNVDHRVAQIFRLDSYTGEISNKEPLDFE-EYKM----YSME 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
VQA + A+ +V I++LD+NDN PE + ++ EN P G + + D+D
Sbjct: 319 VQAQDGAGLM--AKVKVLIKVLDVNDNAPEVTITSVTTAVPENFPPGTIIALISVHDQDS 376
Query: 336 GENGEFTYQLDDPKGAFSIDPR-SGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
G+NG +T F ++ + + + LDRE S + + A + + T
Sbjct: 377 GDNG-YTTCFIPGNLPFKLEKLVDNYYRLVTERTLDRELISGYNITITAIDQGTPALST 434
Score = 46.8 bits (106), Expect = 6e-04
Identities = 46/170 (27%), Positives = 77/170 (45%), Gaps = 20/170 (11%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR-----KLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A D D A + Y LI + S++S G L+ + D + ++Q
Sbjct: 474 VRAHDLDSNENAQITYSLIEDTIQGAPLSAYLSINSDTGVLYALRSFDYEQFRDMQ---- 529
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLP----NGFSV 325
L+V A +P ++ + + LLD NDN PE + + VE P G+ V
Sbjct: 530 -LKVMARDSGDPPLSSNVSLSLFLLDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLV 588
Query: 326 LQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREA 373
+V+A D+D G+N +Y+L G FS+ +G + + +LDR+A
Sbjct: 589 TKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTA-RALLDRDA 637
Score = 46.4 bits (105), Expect = 8e-04
Identities = 36/125 (28%), Positives = 58/125 (46%), Gaps = 5/125 (4%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
++S LF+L+ +GSL + +D + L A + V + L K VE+
Sbjct: 66 IVSRGRMPLFALNPRSGSLITARRIDRE---ELCAQSMPCLVSFNILVED-KMKLFPVEV 121
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
E++D+NDN P+F+++ + E G V D D G N +YQL FS+
Sbjct: 122 EIIDINDNTPQFQLEELEFKMNEITTPGTRVSLPFGQDLDVGMNSLQSYQLSS-NPHFSL 180
Query: 355 DPRSG 359
D + G
Sbjct: 181 DVQQG 185
Score = 43.6 bits (98), Expect = 0.006
Identities = 48/172 (27%), Positives = 77/172 (44%), Gaps = 27/172 (15%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN 1287
G P S T + + V D D + P F Y + + ENV +L+ +N T+ E
Sbjct: 218 GEPVRSGTLRIYIQVVDAND-----NPPAFTQAQYHINVPENVPLGTQLLMVNATDPDEG 272
Query: 1288 FKMRY-YILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPH 1346
Y + D + + F +D G + ++E D +E E + YS E+
Sbjct: 273 ANGEVTYSFHNVDHRVAQIFRLDSYTGEI-----SNKEPLD-FE-----EYKMYSMEVQ- 320
Query: 1347 MIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFG 1398
A+D M K VKV++++ DVNDN+P+ T + + TA+P P G
Sbjct: 321 -----AQDGAGLMAK--VKVLIKVLDVNDNAPEVTITS--VTTAVPENFPPG 363
Score = 40.7 bits (91), Expect = 0.039
Identities = 38/131 (29%), Positives = 59/131 (45%), Gaps = 11/131 (8%)
Query: 436 DEQLMSFVNVEVTLLDANDNNP-VFVPSNLYEFS-----MKSNAKVGTVIGKVKAVDPDL 489
D L S V++ + LLD NDN P + P+ + S +A+ G ++ KV AVD D
Sbjct: 539 DPPLSSNVSLSLFLLDQNDNAPEILYPALPTDGSTGVELAPLSAEPGYLVTKVVAVDRDS 598
Query: 490 GQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSE 547
GQN + Y L + S + F + +TG V A + + + +L V D P
Sbjct: 599 GQNAWLSYRLLKASEPGL---FSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLS 655
Query: 548 RRYSLAVVTIE 558
+L V +
Sbjct: 656 ATVTLTVAVAD 666
Score = 40.3 bits (90), Expect = 0.052
Identities = 42/170 (24%), Positives = 65/170 (38%), Gaps = 12/170 (7%)
Query: 992 FVINERHGHVIVARSLPPESEFRLNISALDGGNL--NDNIS---VRVFVKDVNDHFPVFK 1046
F +N R G +I AR + E ++ L N+ D + V V + D+ND+ P F+
Sbjct: 75 FALNPRSGSLITARRIDREELCAQSMPCLVSFNILVEDKMKLFPVEVEIIDINDNTPQFQ 134
Query: 1047 KTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI-----SPLTGV 1101
F + E + D D G N+ +Y + S+ ++ P
Sbjct: 135 LEELEFKMNEITTPGTRVSLPFGQDLDVGMNSLQSYQLS-SNPHFSLDVQQGADGPQHPE 193
Query: 1102 LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
+ + LDRE E + L + A D G D NDN P F
Sbjct: 194 MVLQSPLDREEEAVHHLILTASDGG-EPVRSGTLRIYIQVVDANDNPPAF 242
Score = 33.5 bits (73), Expect = 6.0
Identities = 17/75 (22%), Positives = 37/75 (49%), Gaps = 3/75 (4%)
Query: 1330 EVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVT 1389
E+++++ + + H+I A D E + +++ +++ D NDN P FT +
Sbjct: 193 EMVLQSPLDREEEAVHHLIL-TASDGGEPVRSGTLRIYIQVVDANDNPPAFTQAQYHI-- 249
Query: 1390 AIPTTAPFGYQVMQL 1404
+P P G Q++ +
Sbjct: 250 NVPENVPLGTQLLMV 264
Score = 33.5 bits (73), Expect = 6.0
Identities = 14/51 (27%), Positives = 23/51 (45%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
+ I G +S +++ + D+NDN P+F Y + E P G F
Sbjct: 422 ITAIDQGTPALSTETHISLLVTDINDNSPVFHQDSYSAYIPENNPRGASIF 472
>BC001186-1|AAH01186.1| 795|Homo sapiens protocadherin beta 5
protein.
Length = 795
Score = 115 bits (277), Expect = 1e-24
Identities = 122/470 (25%), Positives = 199/470 (42%), Gaps = 37/470 (7%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E + F ++ L D ND+ P F P + + + GTV A D D+G N +
Sbjct: 111 ENPVQFFQTDLQLTDINDHAPEF-PEKEMLLKIPESTQPGTVFPLKIAQDFDIGSNTVQN 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI-LEGRH--ALFVEASDQPANPSERRYSLA 553
Y + S+ + + + + V + + E R +L + A D A P ++
Sbjct: 170 YTISPNSHFHVATHNRGDGRKYPELVLDKALDREERPELSLTLTALDGGAPPRSGTTTIR 229
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLL 611
+V ++ N + P+F+ + YE V N + + V + D A V+Y L
Sbjct: 230 IVVLD-------NNDNAPEFLQSFYEVQVPENSPLNSLVVVVSARDLDAGAYGSVAYALF 282
Query: 612 HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVND 671
G E PF ++E++ I + L P Y+ E VA + LS + VVDVND
Sbjct: 283 QGDEVTQPFVIDEKTAEIRLKRALDFEATPYYNVEIVAT-DGGGLSGKCTVAIEVVDVND 341
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI- 730
L S + EN+ + +F + NG R + + Q D+ +
Sbjct: 342 NAPELTM---STLSSPTPENAPETVVA-VFSVSDPDSGDNG----RMICSIQNDLPFLLK 393
Query: 731 -AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
+ T+ TQ+ LDRE + Y +T+ + G + +T+ + D NDN P F
Sbjct: 394 PTLKNFYTLVTQRTLDRESQAEYNITITVT-DMGTPRLKTEHNITVLVSDVNDNAPAFTQ 452
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGK------EMFDVDENT 843
+Y F+ EN+ I + ATD D GTNA Y+L + ++ +
Sbjct: 453 TSYTLFVRENNSPALHI---GSVSATDRDSGTNAQVTYSLLPPQNPHLRLASLVSINADN 509
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
G + F SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 510 GHL-FALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDNSP 558
Score = 80.2 bits (189), Expect = 5e-14
Identities = 66/218 (30%), Positives = 101/218 (46%), Gaps = 24/218 (11%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN P+ + ++ ++A DLD+G G + Y + D EV + FVI+E+
Sbjct: 251 VPENSPLNSLVVVVSARDLDAGAYGSVAY----------ALFQGD--EVTQPFVIDEKTA 298
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFP-VFKKTWYNFNVEE 1056
+ + R+L E+ + + I A DGG L+ +V + V DVND+ P + T + E
Sbjct: 299 EIRLKRALDFEATPYYNVEIVATDGGGLSGKCTVAIEVVDVNDNAPELTMSTLSSPTPEN 358
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETE 1113
A T V+ +D D G N + IQ DLPF + P L LDRE++
Sbjct: 359 APET--VVAVFSVSDPDSGDNGRMICSIQ---NDLPFLLKPTLKNFYTLVTQRTLDRESQ 413
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
+Y +T+ D G DVNDN+P F
Sbjct: 414 AEYNITITVTDMG-TPRLKTEHNITVLVSDVNDNAPAF 450
Score = 79.8 bits (188), Expect = 7e-14
Identities = 123/520 (23%), Positives = 204/520 (39%), Gaps = 72/520 (13%)
Query: 917 TIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYI 976
T +++ N A + + L IPE+ GT A D D G N Y + +
Sbjct: 119 TDLQLTDINDHAPEFPEKEMLLKIPESTQPGTVFPLKIAQDFDIGSNTVQNYTISPNSHF 178
Query: 977 PPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVR 1032
+ + ++ +++ ++L E E L ++ALDGG + ++R
Sbjct: 179 HVATHNRGD---------GRKYPELVLDKALDREERPELSLTLTALDGGAPPRSGTTTIR 229
Query: 1033 VFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSDTDL 1091
+ V D ND+ P F +++Y V E ++ V A D D G ++ Y Q +
Sbjct: 230 IVVLDNNDNAPEFLQSFYEVQVPENSPLNSLVVVVSARDLDAGAYGSVAYALFQGDEVTQ 289
Query: 1092 PFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
PF I T + + LD E Y + +VA D G DVNDN+P+
Sbjct: 290 PFVIDEKTAEIRLKRALDFEATPYYNVEIVATDGG---GLSGKCTVAIEVVDVNDNAPEL 346
Query: 1152 YAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDF----- 1206
L PE + E+V + V+ + ++ G + + ND F
Sbjct: 347 TM--STLSSPTPE------NAPETV--VAVFSVSDPDSGDNGRMICSI-QNDLPFLLKPT 395
Query: 1207 IGNGNGLILYSLPQRKNQ---------QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVF 1257
+ N L+ R++Q ++G P L + + V V+DV D + P F
Sbjct: 396 LKNFYTLVTQRTLDRESQAEYNITITVTDMGTPRLKTEHNITVLVSDVND-----NAPAF 450
Query: 1258 ISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNG 1313
Y L + EN + + + S++ T+ N ++ Y +L + +R + I+ NG
Sbjct: 451 TQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQNPHLRLASLVSINADNG 510
Query: 1314 TLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDV 1373
L+ +RS D E +E V A R P + + V V + D
Sbjct: 511 HLFALRSLDYEALQAFEFRVGAT----DRGSPAL-------------SSEALVRVLVLDA 553
Query: 1374 NDNSP----KFTNGNRPLVTAIPTTAPFGYQVMQLKGAIG 1409
NDNSP NG+ P +P A GY V ++ G
Sbjct: 554 NDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDG 593
Score = 79.4 bits (187), Expect = 9e-14
Identities = 53/154 (34%), Positives = 79/154 (51%), Gaps = 9/154 (5%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
K LDRE+R +T+ A + G +G + I + D NDN P F + YE + ENS
Sbjct: 198 KALDREERPELSLTLTA-LDGGAPPRSGTTTIRIVVLDNNDNAPEFLQSFYEVQVPENSP 256
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM---FDVDENTGVVKFIGDSLDREKK 858
+ + + ++ A D D G Y LF +G E+ F +DE T ++ + +LD E
Sbjct: 257 LNSLVV---VVSARDLDAGAYGSVAYALF-QGDEVTQPFVIDEKTAEIR-LKRALDFEAT 311
Query: 859 IMYKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
Y + +VA D GGLS + + I + D NDN PE
Sbjct: 312 PYYNVEIVATDGGGLSGKCTVAIEVVDVNDNAPE 345
Score = 65.3 bits (152), Expect = 2e-09
Identities = 82/329 (24%), Positives = 136/329 (41%), Gaps = 29/329 (8%)
Query: 77 ISAYLSVTVYIEDVNDNVP-IFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVP 135
+S +V + + DVNDN P + + T T + T F G + + ++
Sbjct: 326 LSGKCTVAIEVVDVNDNAPELTMSTLSSPTPENAPETVVAVFSVSDPDSGDNGRMICSIQ 385
Query: 136 RGLTIF-----KDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLD 189
L K+ + S Y+I ++ D G L++ H +L+ V D
Sbjct: 386 NDLPFLLKPTLKNFYTLVTQRTLDRESQAEYNITITVTDMGTPRLKTEHNITVLVSDVND 445
Query: 190 YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLF 244
+ + + + L + A D+D G A + Y L+ + L
Sbjct: 446 NAPAFTQTSYTLFV--RENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQNPHLRLASLV 503
Query: 245 SLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLP 304
S+++ NG LF + LD +A LQA F +V A+ +P +++A V + +LD NDN P
Sbjct: 504 SINADNGHLFALRSLDYEA---LQA--FEFRVGATDRGSPALSSEALVRVLVLDANDNSP 558
Query: 305 EFEVDFYNIS--IVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDP 356
N S E +P G+ V +V+A D D G+N +YQL G FS+
Sbjct: 559 FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFSMWA 618
Query: 357 RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+G VR +L + R+ V K+
Sbjct: 619 HNG--EVRTARLLSERDAAKHRLVVLVKD 645
Score = 60.1 bits (139), Expect = 6e-08
Identities = 66/281 (23%), Positives = 109/281 (38%), Gaps = 16/281 (5%)
Query: 635 LSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSA 693
L R RP AL A S T + V+D ND L+ + V ENS
Sbjct: 200 LDREERPELSLTLTALDGGAPPRSGTTTIRIVVLDNNDNAPEFLQSFYE---VQVPENSP 256
Query: 694 GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED-GTIFTQKPLDREKRDVY 752
++ + + + G+V + + +VT I E I ++ LD E Y
Sbjct: 257 LNSL--VVVVSARDLDAGAYGSVAYALFQGDEVTQPFVIDEKTAEIRLKRALDFEATPYY 314
Query: 753 RMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNII 812
+ ++A G+ +G V I + D NDN P +T EN+ T + +
Sbjct: 315 NVEIVATDGGGL---SGKCTVAIEVVDVNDNAPELTMSTLSSPTPENAP-ETVVA---VF 367
Query: 813 KATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG 872
+D D G N + ++ + + +LDRE + Y +++ D G
Sbjct: 368 SVSDPDSGDNGRMICSIQNDLPFLLKPTLKNFYTLVTQRTLDRESQAEYNITITVTDMGT 427
Query: 873 --LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
L +E + +++ D NDN P F Q VR + L+
Sbjct: 428 PRLKTEHNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALH 468
Score = 59.7 bits (138), Expect = 8e-08
Identities = 59/200 (29%), Positives = 84/200 (42%), Gaps = 19/200 (9%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
LF+ N P I ++A D DSG N Q+ Y +PP L + IN
Sbjct: 457 LFVRENNSP-ALHIGSVSATDRDSGTNAQVTYSL-----LPPQN---PHLRLASLVSINA 507
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+GH+ RSL E+ F + A D G+ L+ VRV V D ND+ P N
Sbjct: 508 DNGHLFALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNG 567
Query: 1053 NVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
+ + R ++ KV A D D GQNA L+Y + + F + G +
Sbjct: 568 SAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFSMWAHNGEVRTAR 627
Query: 1107 ELDRETEDKYILTVVARDNG 1126
L K+ L V+ +DNG
Sbjct: 628 LLSERDAAKHRLVVLVKDNG 647
Score = 58.0 bits (134), Expect = 2e-07
Identities = 51/178 (28%), Positives = 79/178 (44%), Gaps = 11/178 (6%)
Query: 213 LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELD--LDAEHNLQAN 270
+FP I A D D+G Y + + + + + +G + E LD LD E + +
Sbjct: 151 VFPLKI-AQDFDIGSNTVQNYTISPNSHFHVATHNRGDGRKYPELVLDKALDREERPELS 209
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
L + A P ++ + I +LD NDN PEF FY + + EN P V+ V A
Sbjct: 210 ---LTLTALDGGAPPRSGTTTIRIVVLDNNDNAPEFLQSFYEVQVPENSPLNSLVVVVSA 266
Query: 331 TDKDQGENGEFTYQL---DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D D G G Y L D+ F ID ++ +R + LD EA +++ A +
Sbjct: 267 RDLDAGAYGSVAYALFQGDEVTQPFVIDEKTA--EIRLKRALDFEATPYYNVEIVATD 322
Score = 50.8 bits (116), Expect = 4e-05
Identities = 42/167 (25%), Positives = 76/167 (45%), Gaps = 13/167 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGND-RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D D G ++ Y L G++ + F +D + L++ LD +A N ++
Sbjct: 264 VSARDLDAGAYGSVAYALFQGDEVTQPFVIDEKTAEIRLKRALDFEATPYY--NVEIVAT 321
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA-TDKDQ 335
L+ + V IE++D+NDN PE + + EN P +V+ V + +D D
Sbjct: 322 DGGGLSG-----KCTVAIEVVDVNDNAPELTMSTLSSPTPENAPE--TVVAVFSVSDPDS 374
Query: 336 GENGEFTYQLDDPKGAFSIDPR-SGWLTVRNQTVLDREAHSSLRMKV 381
G+NG + + F + P + T+ Q LDRE+ + + +
Sbjct: 375 GDNGRMICSIQNDL-PFLLKPTLKNFYTLVTQRTLDRESQAEYNITI 420
Score = 45.6 bits (103), Expect = 0.001
Identities = 47/183 (25%), Positives = 77/183 (42%), Gaps = 13/183 (7%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G + + LDRE I F + + +Q + + D ND+ P F
Sbjct: 82 GNLLLYEKLDREVMCGATEPCILHFQLLLENPVQFFQTDLQLTDINDHAPEFPEKEMLLK 141
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVK-----FIG 850
I E+++ GT + A D D G+N + YT+ N G + +
Sbjct: 142 IPESTQPGTVFPLKI---AQDFDIGSNTVQNYTI-SPNSHFHVATHNRGDGRKYPELVLD 197
Query: 851 DSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRET 908
+LDRE++ L+L A D G S + I++ D NDN PEF ++ +V++ +
Sbjct: 198 KALDREERPELSLTLTALDGGAPPRSGTTTIRIVVLDNNDNAPEF--LQSFYEVQVPENS 255
Query: 909 KLN 911
LN
Sbjct: 256 PLN 258
Score = 41.5 bits (93), Expect = 0.022
Identities = 40/137 (29%), Positives = 61/137 (44%), Gaps = 7/137 (5%)
Query: 220 AIDQDLGVG--ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
A D LGVG AT + +++L LD G+L L ++LD + +L Q
Sbjct: 49 AKDLGLGVGELATRGARMHYKGNKELLQLDIKTGNLLLYEKLDREVMCGA-TEPCILHFQ 107
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
L NP++ Q +++L D+ND+ PEF + I E+ G +A D D G
Sbjct: 108 LL-LENPVQFFQT--DLQLTDINDHAPEFPEKEMLLKIPESTQPGTVFPLKIAQDFDIGS 164
Query: 338 NGEFTYQLDDPKGAFSI 354
N Y + P F +
Sbjct: 165 NTVQNYTI-SPNSHFHV 180
Score = 41.1 bits (92), Expect = 0.030
Identities = 39/126 (30%), Positives = 55/126 (43%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 540 LSSEALVRVLVLDANDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 598
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + + S + N T + S +H L V D P +L
Sbjct: 599 AWLSYQLLKATEPGLFSMWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 657
Query: 553 AVVTIE 558
V+ ++
Sbjct: 658 HVLLVD 663
>AF217753-1|AAK51620.1| 795|Homo sapiens protocadherin-beta5
protein.
Length = 795
Score = 115 bits (277), Expect = 1e-24
Identities = 122/470 (25%), Positives = 199/470 (42%), Gaps = 37/470 (7%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E + F ++ L D ND+ P F P + + + GTV A D D+G N +
Sbjct: 111 ENPVQFFQTDLQLTDINDHAPEF-PEKEMLLKIPESTQPGTVFPLKIAQDFDIGSNTVQN 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI-LEGRH--ALFVEASDQPANPSERRYSLA 553
Y + S+ + + + + V + + E R +L + A D A P ++
Sbjct: 170 YTISPNSHFHVATHNRGDGRKYPELVLDKALDREERPELSLTLTALDGGAPPRSGTTTIR 229
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLL 611
+V ++ N + P+F+ + YE V N + + V + D A V+Y L
Sbjct: 230 IVVLD-------NNDNAPEFLQSFYEVQVPENSPLNSLVVVVSARDLDAGAYGSVAYALF 282
Query: 612 HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVND 671
G E PF ++E++ I + L P Y+ E VA + LS + VVDVND
Sbjct: 283 QGDEVTQPFVIDEKTAEIRLKRALDFEATPYYNVEIVAT-DGGGLSGKCTVAIEVVDVND 341
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI- 730
L S + EN+ + +F + NG R + + Q D+ +
Sbjct: 342 NAPELTM---STLSSPTPENAPETVVA-VFSVSDPDSGDNG----RMICSIQNDLPFLLK 393
Query: 731 -AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
+ T+ TQ+ LDRE + Y +T+ + G + +T+ + D NDN P F
Sbjct: 394 PTLKNFYTLVTQRTLDRESQAEYNITITVT-DMGTPRLKTEHNITVLVSDVNDNAPAFTQ 452
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGK------EMFDVDENT 843
+Y F+ EN+ I + ATD D GTNA Y+L + ++ +
Sbjct: 453 TSYTLFVRENNSPALHI---GSVSATDRDSGTNAQVTYSLLPPQNPHLRLASLVSINADN 509
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
G + F SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 510 GHL-FALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDNSP 558
Score = 80.2 bits (189), Expect = 5e-14
Identities = 66/218 (30%), Positives = 101/218 (46%), Gaps = 24/218 (11%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN P+ + ++ ++A DLD+G G + Y + D EV + FVI+E+
Sbjct: 251 VPENSPLNSLVVVVSARDLDAGAYGSVAY----------ALFQGD--EVTQPFVIDEKTA 298
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFP-VFKKTWYNFNVEE 1056
+ + R+L E+ + + I A DGG L+ +V + V DVND+ P + T + E
Sbjct: 299 EIRLKRALDFEATPYYNVEIVATDGGGLSGKCTVAIEVVDVNDNAPELTMSTLSSPTPEN 358
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETE 1113
A T V+ +D D G N + IQ DLPF + P L LDRE++
Sbjct: 359 APET--VVAVFSVSDPDSGDNGRMICSIQ---NDLPFLLKPTLKNFYTLVTQRTLDRESQ 413
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
+Y +T+ D G DVNDN+P F
Sbjct: 414 AEYNITITVTDMG-TPRLKTEHNITVLVSDVNDNAPAF 450
Score = 79.8 bits (188), Expect = 7e-14
Identities = 123/520 (23%), Positives = 204/520 (39%), Gaps = 72/520 (13%)
Query: 917 TIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYI 976
T +++ N A + + L IPE+ GT A D D G N Y + +
Sbjct: 119 TDLQLTDINDHAPEFPEKEMLLKIPESTQPGTVFPLKIAQDFDIGSNTVQNYTISPNSHF 178
Query: 977 PPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVR 1032
+ + ++ +++ ++L E E L ++ALDGG + ++R
Sbjct: 179 HVATHNRGD---------GRKYPELVLDKALDREERPELSLTLTALDGGAPPRSGTTTIR 229
Query: 1033 VFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSDTDL 1091
+ V D ND+ P F +++Y V E ++ V A D D G ++ Y Q +
Sbjct: 230 IVVLDNNDNAPEFLQSFYEVQVPENSPLNSLVVVVSARDLDAGAYGSVAYALFQGDEVTQ 289
Query: 1092 PFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
PF I T + + LD E Y + +VA D G DVNDN+P+
Sbjct: 290 PFVIDEKTAEIRLKRALDFEATPYYNVEIVATDGG---GLSGKCTVAIEVVDVNDNAPEL 346
Query: 1152 YAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDF----- 1206
L PE + E+V + V+ + ++ G + + ND F
Sbjct: 347 TM--STLSSPTPE------NAPETV--VAVFSVSDPDSGDNGRMICSI-QNDLPFLLKPT 395
Query: 1207 IGNGNGLILYSLPQRKNQ---------QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVF 1257
+ N L+ R++Q ++G P L + + V V+DV D + P F
Sbjct: 396 LKNFYTLVTQRTLDRESQAEYNITITVTDMGTPRLKTEHNITVLVSDVND-----NAPAF 450
Query: 1258 ISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNG 1313
Y L + EN + + + S++ T+ N ++ Y +L + +R + I+ NG
Sbjct: 451 TQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQNPHLRLASLVSINADNG 510
Query: 1314 TLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDV 1373
L+ +RS D E +E V A R P + + V V + D
Sbjct: 511 HLFALRSLDYEALQAFEFRVGAT----DRGSPAL-------------SSEALVRVLVLDA 553
Query: 1374 NDNSP----KFTNGNRPLVTAIPTTAPFGYQVMQLKGAIG 1409
NDNSP NG+ P +P A GY V ++ G
Sbjct: 554 NDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDG 593
Score = 79.4 bits (187), Expect = 9e-14
Identities = 53/154 (34%), Positives = 79/154 (51%), Gaps = 9/154 (5%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
K LDRE+R +T+ A + G +G + I + D NDN P F + YE + ENS
Sbjct: 198 KALDREERPELSLTLTA-LDGGAPPRSGTTTIRIVVLDNNDNAPEFLQSFYEVQVPENSP 256
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM---FDVDENTGVVKFIGDSLDREKK 858
+ + + ++ A D D G Y LF +G E+ F +DE T ++ + +LD E
Sbjct: 257 LNSLVV---VVSARDLDAGAYGSVAYALF-QGDEVTQPFVIDEKTAEIR-LKRALDFEAT 311
Query: 859 IMYKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
Y + +VA D GGLS + + I + D NDN PE
Sbjct: 312 PYYNVEIVATDGGGLSGKCTVAIEVVDVNDNAPE 345
Score = 65.3 bits (152), Expect = 2e-09
Identities = 82/329 (24%), Positives = 136/329 (41%), Gaps = 29/329 (8%)
Query: 77 ISAYLSVTVYIEDVNDNVP-IFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVP 135
+S +V + + DVNDN P + + T T + T F G + + ++
Sbjct: 326 LSGKCTVAIEVVDVNDNAPELTMSTLSSPTPENAPETVVAVFSVSDPDSGDNGRMICSIQ 385
Query: 136 RGLTIF-----KDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLD 189
L K+ + S Y+I ++ D G L++ H +L+ V D
Sbjct: 386 NDLPFLLKPTLKNFYTLVTQRTLDRESQAEYNITITVTDMGTPRLKTEHNITVLVSDVND 445
Query: 190 YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLF 244
+ + + + L + A D+D G A + Y L+ + L
Sbjct: 446 NAPAFTQTSYTLFV--RENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQNPHLRLASLV 503
Query: 245 SLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLP 304
S+++ NG LF + LD +A LQA F +V A+ +P +++A V + +LD NDN P
Sbjct: 504 SINADNGHLFALRSLDYEA---LQA--FEFRVGATDRGSPALSSEALVRVLVLDANDNSP 558
Query: 305 EFEVDFYNIS--IVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDP 356
N S E +P G+ V +V+A D D G+N +YQL G FS+
Sbjct: 559 FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFSMWA 618
Query: 357 RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+G VR +L + R+ V K+
Sbjct: 619 HNG--EVRTARLLSERDAAKHRLVVLVKD 645
Score = 60.1 bits (139), Expect = 6e-08
Identities = 66/281 (23%), Positives = 109/281 (38%), Gaps = 16/281 (5%)
Query: 635 LSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSA 693
L R RP AL A S T + V+D ND L+ + V ENS
Sbjct: 200 LDREERPELSLTLTALDGGAPPRSGTTTIRIVVLDNNDNAPEFLQSFYE---VQVPENSP 256
Query: 694 GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED-GTIFTQKPLDREKRDVY 752
++ + + + G+V + + +VT I E I ++ LD E Y
Sbjct: 257 LNSL--VVVVSARDLDAGAYGSVAYALFQGDEVTQPFVIDEKTAEIRLKRALDFEATPYY 314
Query: 753 RMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNII 812
+ ++A G+ +G V I + D NDN P +T EN+ T + +
Sbjct: 315 NVEIVATDGGGL---SGKCTVAIEVVDVNDNAPELTMSTLSSPTPENAP-ETVVA---VF 367
Query: 813 KATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG 872
+D D G N + ++ + + +LDRE + Y +++ D G
Sbjct: 368 SVSDPDSGDNGRMICSIQNDLPFLLKPTLKNFYTLVTQRTLDRESQAEYNITITVTDMGT 427
Query: 873 --LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
L +E + +++ D NDN P F Q VR + L+
Sbjct: 428 PRLKTEHNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALH 468
Score = 59.7 bits (138), Expect = 8e-08
Identities = 59/200 (29%), Positives = 84/200 (42%), Gaps = 19/200 (9%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
LF+ N P I ++A D DSG N Q+ Y +PP L + IN
Sbjct: 457 LFVRENNSP-ALHIGSVSATDRDSGTNAQVTYSL-----LPPQN---PHLRLASLVSINA 507
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+GH+ RSL E+ F + A D G+ L+ VRV V D ND+ P N
Sbjct: 508 DNGHLFALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNG 567
Query: 1053 NVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
+ + R ++ KV A D D GQNA L+Y + + F + G +
Sbjct: 568 SAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFSMWAHNGEVRTAR 627
Query: 1107 ELDRETEDKYILTVVARDNG 1126
L K+ L V+ +DNG
Sbjct: 628 LLSERDAAKHRLVVLVKDNG 647
Score = 58.0 bits (134), Expect = 2e-07
Identities = 51/178 (28%), Positives = 79/178 (44%), Gaps = 11/178 (6%)
Query: 213 LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELD--LDAEHNLQAN 270
+FP I A D D+G Y + + + + + +G + E LD LD E + +
Sbjct: 151 VFPLKI-AQDFDIGSNTVQNYTISPNSHFHVATHNRGDGRKYPELVLDKALDREERPELS 209
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
L + A P ++ + I +LD NDN PEF FY + + EN P V+ V A
Sbjct: 210 ---LTLTALDGGAPPRSGTTTIRIVVLDNNDNAPEFLQSFYEVQVPENSPLNSLVVVVSA 266
Query: 331 TDKDQGENGEFTYQL---DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D D G G Y L D+ F ID ++ +R + LD EA +++ A +
Sbjct: 267 RDLDAGAYGSVAYALFQGDEVTQPFVIDEKTA--EIRLKRALDFEATPYYNVEIVATD 322
Score = 50.8 bits (116), Expect = 4e-05
Identities = 42/167 (25%), Positives = 76/167 (45%), Gaps = 13/167 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGND-RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D D G ++ Y L G++ + F +D + L++ LD +A N ++
Sbjct: 264 VSARDLDAGAYGSVAYALFQGDEVTQPFVIDEKTAEIRLKRALDFEATPYY--NVEIVAT 321
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA-TDKDQ 335
L+ + V IE++D+NDN PE + + EN P +V+ V + +D D
Sbjct: 322 DGGGLSG-----KCTVAIEVVDVNDNAPELTMSTLSSPTPENAPE--TVVAVFSVSDPDS 374
Query: 336 GENGEFTYQLDDPKGAFSIDPR-SGWLTVRNQTVLDREAHSSLRMKV 381
G+NG + + F + P + T+ Q LDRE+ + + +
Sbjct: 375 GDNGRMICSIQNDL-PFLLKPTLKNFYTLVTQRTLDRESQAEYNITI 420
Score = 45.6 bits (103), Expect = 0.001
Identities = 47/183 (25%), Positives = 77/183 (42%), Gaps = 13/183 (7%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G + + LDRE I F + + +Q + + D ND+ P F
Sbjct: 82 GNLLLYEKLDREVMCGATEPCILHFQLLLENPVQFFQTDLQLTDINDHAPEFPEKEMLLK 141
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVK-----FIG 850
I E+++ GT + A D D G+N + YT+ N G + +
Sbjct: 142 IPESTQPGTVFPLKI---AQDFDIGSNTVQNYTI-SPNSHFHVATHNRGDGRKYPELVLD 197
Query: 851 DSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRET 908
+LDRE++ L+L A D G S + I++ D NDN PEF ++ +V++ +
Sbjct: 198 KALDREERPELSLTLTALDGGAPPRSGTTTIRIVVLDNNDNAPEF--LQSFYEVQVPENS 255
Query: 909 KLN 911
LN
Sbjct: 256 PLN 258
Score = 41.5 bits (93), Expect = 0.022
Identities = 40/137 (29%), Positives = 61/137 (44%), Gaps = 7/137 (5%)
Query: 220 AIDQDLGVG--ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
A D LGVG AT + +++L LD G+L L ++LD + +L Q
Sbjct: 49 AKDLGLGVGELATRGARMHYKGNKELLQLDIKTGNLLLYEKLDREVMCGA-TEPCILHFQ 107
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
L NP++ Q +++L D+ND+ PEF + I E+ G +A D D G
Sbjct: 108 LL-LENPVQFFQT--DLQLTDINDHAPEFPEKEMLLKIPESTQPGTVFPLKIAQDFDIGS 164
Query: 338 NGEFTYQLDDPKGAFSI 354
N Y + P F +
Sbjct: 165 NTVQNYTI-SPNSHFHV 180
Score = 41.1 bits (92), Expect = 0.030
Identities = 39/126 (30%), Positives = 55/126 (43%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 540 LSSEALVRVLVLDANDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 598
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + + S + N T + S +H L V D P +L
Sbjct: 599 AWLSYQLLKATEPGLFSMWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 657
Query: 553 AVVTIE 558
V+ ++
Sbjct: 658 HVLLVD 663
>AF152498-1|AAD43759.1| 795|Homo sapiens protocadherin beta 5
protein.
Length = 795
Score = 115 bits (277), Expect = 1e-24
Identities = 122/470 (25%), Positives = 199/470 (42%), Gaps = 37/470 (7%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E + F ++ L D ND+ P F P + + + GTV A D D+G N +
Sbjct: 111 ENPVQFFQTDLQLTDINDHAPEF-PEKEMLLKIPESTQPGTVFPLKIAQDFDIGSNTVQN 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI-LEGRH--ALFVEASDQPANPSERRYSLA 553
Y + S+ + + + + V + + E R +L + A D A P ++
Sbjct: 170 YTISPNSHFHVATHNRGDGRKYPELVLDKALDREERPELSLTLTALDGGAPPRSGTTTIR 229
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLL 611
+V ++ N + P+F+ + YE V N + + V + D A V+Y L
Sbjct: 230 IVVLD-------NNDNAPEFLQSFYEVQVPENSPLNSLVVVVSARDLDAGAYGSVAYALF 282
Query: 612 HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVND 671
G E PF ++E++ I + L P Y+ E VA + LS + VVDVND
Sbjct: 283 QGDEVTQPFVIDEKTAEIRLKRALDFEATPYYNVEIVAT-DGGGLSGKCTVAIEVVDVND 341
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI- 730
L S + EN+ + +F + NG R + + Q D+ +
Sbjct: 342 NAPELTM---STLSSPTPENAPETVVA-VFSVSDPDSGDNG----RMICSIQNDLPFLLK 393
Query: 731 -AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
+ T+ TQ+ LDRE + Y +T+ + G + +T+ + D NDN P F
Sbjct: 394 PTLKNFYTLVTQRTLDRESQAEYNITITVT-DMGTPRLKTEHNITVLVSDVNDNAPAFTQ 452
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGK------EMFDVDENT 843
+Y F+ EN+ I + ATD D GTNA Y+L + ++ +
Sbjct: 453 TSYTLFVRENNSPALHI---GSVSATDRDSGTNAQVTYSLLPPQNPHLRLASLVSINADN 509
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
G + F SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 510 GHL-FALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDNSP 558
Score = 80.2 bits (189), Expect = 5e-14
Identities = 66/218 (30%), Positives = 101/218 (46%), Gaps = 24/218 (11%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN P+ + ++ ++A DLD+G G + Y + D EV + FVI+E+
Sbjct: 251 VPENSPLNSLVVVVSARDLDAGAYGSVAY----------ALFQGD--EVTQPFVIDEKTA 298
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFP-VFKKTWYNFNVEE 1056
+ + R+L E+ + + I A DGG L+ +V + V DVND+ P + T + E
Sbjct: 299 EIRLKRALDFEATPYYNVEIVATDGGGLSGKCTVAIEVVDVNDNAPELTMSTLSSPTPEN 358
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETE 1113
A T V+ +D D G N + IQ DLPF + P L LDRE++
Sbjct: 359 APET--VVAVFSVSDPDSGDNGRMICSIQ---NDLPFLLKPTLKNFYTLVTQRTLDRESQ 413
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
+Y +T+ D G DVNDN+P F
Sbjct: 414 AEYNITITVTDMG-TPRLKTEHNITVLVSDVNDNAPAF 450
Score = 79.8 bits (188), Expect = 7e-14
Identities = 123/520 (23%), Positives = 204/520 (39%), Gaps = 72/520 (13%)
Query: 917 TIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYI 976
T +++ N A + + L IPE+ GT A D D G N Y + +
Sbjct: 119 TDLQLTDINDHAPEFPEKEMLLKIPESTQPGTVFPLKIAQDFDIGSNTVQNYTISPNSHF 178
Query: 977 PPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVR 1032
+ + ++ +++ ++L E E L ++ALDGG + ++R
Sbjct: 179 HVATHNRGD---------GRKYPELVLDKALDREERPELSLTLTALDGGAPPRSGTTTIR 229
Query: 1033 VFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSDTDL 1091
+ V D ND+ P F +++Y V E ++ V A D D G ++ Y Q +
Sbjct: 230 IVVLDNNDNAPEFLQSFYEVQVPENSPLNSLVVVVSARDLDAGAYGSVAYALFQGDEVTQ 289
Query: 1092 PFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
PF I T + + LD E Y + +VA D G DVNDN+P+
Sbjct: 290 PFVIDEKTAEIRLKRALDFEATPYYNVEIVATDGG---GLSGKCTVAIEVVDVNDNAPEL 346
Query: 1152 YAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDF----- 1206
L PE + E+V + V+ + ++ G + + ND F
Sbjct: 347 TM--STLSSPTPE------NAPETV--VAVFSVSDPDSGDNGRMICSI-QNDLPFLLKPT 395
Query: 1207 IGNGNGLILYSLPQRKNQ---------QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVF 1257
+ N L+ R++Q ++G P L + + V V+DV D + P F
Sbjct: 396 LKNFYTLVTQRTLDRESQAEYNITITVTDMGTPRLKTEHNITVLVSDVND-----NAPAF 450
Query: 1258 ISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNG 1313
Y L + EN + + + S++ T+ N ++ Y +L + +R + I+ NG
Sbjct: 451 TQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQNPHLRLASLVSINADNG 510
Query: 1314 TLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDV 1373
L+ +RS D E +E V A R P + + V V + D
Sbjct: 511 HLFALRSLDYEALQAFEFRVGAT----DRGSPAL-------------SSEALVRVLVLDA 553
Query: 1374 NDNSP----KFTNGNRPLVTAIPTTAPFGYQVMQLKGAIG 1409
NDNSP NG+ P +P A GY V ++ G
Sbjct: 554 NDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDG 593
Score = 79.4 bits (187), Expect = 9e-14
Identities = 53/154 (34%), Positives = 79/154 (51%), Gaps = 9/154 (5%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
K LDRE+R +T+ A + G +G + I + D NDN P F + YE + ENS
Sbjct: 198 KALDREERPELSLTLTA-LDGGAPPRSGTTTIRIVVLDNNDNAPEFLQSFYEVQVPENSP 256
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM---FDVDENTGVVKFIGDSLDREKK 858
+ + + ++ A D D G Y LF +G E+ F +DE T ++ + +LD E
Sbjct: 257 LNSLVV---VVSARDLDAGAYGSVAYALF-QGDEVTQPFVIDEKTAEIR-LKRALDFEAT 311
Query: 859 IMYKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
Y + +VA D GGLS + + I + D NDN PE
Sbjct: 312 PYYNVEIVATDGGGLSGKCTVAIEVVDVNDNAPE 345
Score = 65.3 bits (152), Expect = 2e-09
Identities = 82/329 (24%), Positives = 136/329 (41%), Gaps = 29/329 (8%)
Query: 77 ISAYLSVTVYIEDVNDNVP-IFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVP 135
+S +V + + DVNDN P + + T T + T F G + + ++
Sbjct: 326 LSGKCTVAIEVVDVNDNAPELTMSTLSSPTPENAPETVVAVFSVSDPDSGDNGRMICSIQ 385
Query: 136 RGLTIF-----KDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLD 189
L K+ + S Y+I ++ D G L++ H +L+ V D
Sbjct: 386 NDLPFLLKPTLKNFYTLVTQRTLDRESQAEYNITITVTDMGTPRLKTEHNITVLVSDVND 445
Query: 190 YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLF 244
+ + + + L + A D+D G A + Y L+ + L
Sbjct: 446 NAPAFTQTSYTLFV--RENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQNPHLRLASLV 503
Query: 245 SLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLP 304
S+++ NG LF + LD +A LQA F +V A+ +P +++A V + +LD NDN P
Sbjct: 504 SINADNGHLFALRSLDYEA---LQA--FEFRVGATDRGSPALSSEALVRVLVLDANDNSP 558
Query: 305 EFEVDFYNIS--IVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDP 356
N S E +P G+ V +V+A D D G+N +YQL G FS+
Sbjct: 559 FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFSMWA 618
Query: 357 RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+G VR +L + R+ V K+
Sbjct: 619 HNG--EVRTARLLSERDAAKHRLVVLVKD 645
Score = 60.1 bits (139), Expect = 6e-08
Identities = 66/281 (23%), Positives = 109/281 (38%), Gaps = 16/281 (5%)
Query: 635 LSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSA 693
L R RP AL A S T + V+D ND L+ + V ENS
Sbjct: 200 LDREERPELSLTLTALDGGAPPRSGTTTIRIVVLDNNDNAPEFLQSFYE---VQVPENSP 256
Query: 694 GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED-GTIFTQKPLDREKRDVY 752
++ + + + G+V + + +VT I E I ++ LD E Y
Sbjct: 257 LNSL--VVVVSARDLDAGAYGSVAYALFQGDEVTQPFVIDEKTAEIRLKRALDFEATPYY 314
Query: 753 RMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNII 812
+ ++A G+ +G V I + D NDN P +T EN+ T + +
Sbjct: 315 NVEIVATDGGGL---SGKCTVAIEVVDVNDNAPELTMSTLSSPTPENAP-ETVVA---VF 367
Query: 813 KATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG 872
+D D G N + ++ + + +LDRE + Y +++ D G
Sbjct: 368 SVSDPDSGDNGRMICSIQNDLPFLLKPTLKNFYTLVTQRTLDRESQAEYNITITVTDMGT 427
Query: 873 --LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
L +E + +++ D NDN P F Q VR + L+
Sbjct: 428 PRLKTEHNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALH 468
Score = 59.7 bits (138), Expect = 8e-08
Identities = 59/200 (29%), Positives = 84/200 (42%), Gaps = 19/200 (9%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
LF+ N P I ++A D DSG N Q+ Y +PP L + IN
Sbjct: 457 LFVRENNSP-ALHIGSVSATDRDSGTNAQVTYSL-----LPPQN---PHLRLASLVSINA 507
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+GH+ RSL E+ F + A D G+ L+ VRV V D ND+ P N
Sbjct: 508 DNGHLFALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNG 567
Query: 1053 NVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
+ + R ++ KV A D D GQNA L+Y + + F + G +
Sbjct: 568 SAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFSMWAHNGEVRTAR 627
Query: 1107 ELDRETEDKYILTVVARDNG 1126
L K+ L V+ +DNG
Sbjct: 628 LLSERDAAKHRLVVLVKDNG 647
Score = 58.0 bits (134), Expect = 2e-07
Identities = 51/178 (28%), Positives = 79/178 (44%), Gaps = 11/178 (6%)
Query: 213 LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELD--LDAEHNLQAN 270
+FP I A D D+G Y + + + + + +G + E LD LD E + +
Sbjct: 151 VFPLKI-AQDFDIGSNTVQNYTISPNSHFHVATHNRGDGRKYPELVLDKALDREERPELS 209
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
L + A P ++ + I +LD NDN PEF FY + + EN P V+ V A
Sbjct: 210 ---LTLTALDGGAPPRSGTTTIRIVVLDNNDNAPEFLQSFYEVQVPENSPLNSLVVVVSA 266
Query: 331 TDKDQGENGEFTYQL---DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D D G G Y L D+ F ID ++ +R + LD EA +++ A +
Sbjct: 267 RDLDAGAYGSVAYALFQGDEVTQPFVIDEKTA--EIRLKRALDFEATPYYNVEIVATD 322
Score = 50.8 bits (116), Expect = 4e-05
Identities = 42/167 (25%), Positives = 76/167 (45%), Gaps = 13/167 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGND-RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D D G ++ Y L G++ + F +D + L++ LD +A N ++
Sbjct: 264 VSARDLDAGAYGSVAYALFQGDEVTQPFVIDEKTAEIRLKRALDFEATPYY--NVEIVAT 321
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA-TDKDQ 335
L+ + V IE++D+NDN PE + + EN P +V+ V + +D D
Sbjct: 322 DGGGLSG-----KCTVAIEVVDVNDNAPELTMSTLSSPTPENAPE--TVVAVFSVSDPDS 374
Query: 336 GENGEFTYQLDDPKGAFSIDPR-SGWLTVRNQTVLDREAHSSLRMKV 381
G+NG + + F + P + T+ Q LDRE+ + + +
Sbjct: 375 GDNGRMICSIQNDL-PFLLKPTLKNFYTLVTQRTLDRESQAEYNITI 420
Score = 45.6 bits (103), Expect = 0.001
Identities = 47/183 (25%), Positives = 77/183 (42%), Gaps = 13/183 (7%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G + + LDRE I F + + +Q + + D ND+ P F
Sbjct: 82 GNLLLYEKLDREVMCGATEPCILHFQLLLENPVQFFQTDLQLTDINDHAPEFPEKEMLLK 141
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVK-----FIG 850
I E+++ GT + A D D G+N + YT+ N G + +
Sbjct: 142 IPESTQPGTVFPLKI---AQDFDIGSNTVQNYTI-SPNSHFHVATHNRGDGRKYPELVLD 197
Query: 851 DSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRET 908
+LDRE++ L+L A D G S + I++ D NDN PEF ++ +V++ +
Sbjct: 198 KALDREERPELSLTLTALDGGAPPRSGTTTIRIVVLDNNDNAPEF--LQSFYEVQVPENS 255
Query: 909 KLN 911
LN
Sbjct: 256 PLN 258
Score = 41.5 bits (93), Expect = 0.022
Identities = 40/137 (29%), Positives = 61/137 (44%), Gaps = 7/137 (5%)
Query: 220 AIDQDLGVG--ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
A D LGVG AT + +++L LD G+L L ++LD + +L Q
Sbjct: 49 AKDLGLGVGELATRGARMHYKGNKELLQLDIKTGNLLLYEKLDREVMCGA-TEPCILHFQ 107
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
L NP++ Q +++L D+ND+ PEF + I E+ G +A D D G
Sbjct: 108 LL-LENPVQFFQT--DLQLTDINDHAPEFPEKEMLLKIPESTQPGTVFPLKIAQDFDIGS 164
Query: 338 NGEFTYQLDDPKGAFSI 354
N Y + P F +
Sbjct: 165 NTVQNYTI-SPNSHFHV 180
Score = 41.1 bits (92), Expect = 0.030
Identities = 39/126 (30%), Positives = 55/126 (43%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 540 LSSEALVRVLVLDANDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 598
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + + S + N T + S +H L V D P +L
Sbjct: 599 AWLSYQLLKATEPGLFSMWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 657
Query: 553 AVVTIE 558
V+ ++
Sbjct: 658 HVLLVD 663
>AF134474-1|AAP97251.1| 795|Homo sapiens protocadherin protein.
Length = 795
Score = 115 bits (277), Expect = 1e-24
Identities = 122/470 (25%), Positives = 199/470 (42%), Gaps = 37/470 (7%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E + F ++ L D ND+ P F P + + + GTV A D D+G N +
Sbjct: 111 ENPVQFFQTDLQLTDINDHAPEF-PEKEMLLKIPESTQPGTVFPLKIAQDFDIGSNTVQN 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI-LEGRH--ALFVEASDQPANPSERRYSLA 553
Y + S+ + + + + V + + E R +L + A D A P ++
Sbjct: 170 YTISPNSHFHVATHNRGDGRKYPELVLDKALDREERPELSLTLTALDGGAPPRSGTTTIR 229
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLL 611
+V ++ N + P+F+ + YE V N + + V + D A V+Y L
Sbjct: 230 IVVLD-------NNDNAPEFLQSFYEVQVPENSPLNSLVVVVSARDLDAGAYGSVAYALF 282
Query: 612 HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVND 671
G E PF ++E++ I + L P Y+ E VA + LS + VVDVND
Sbjct: 283 QGDEVTQPFVIDEKTAEIRLKRALDFEATPYYNVEIVAT-DGGGLSGKCTVAIEVVDVND 341
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI- 730
L S + EN+ + +F + NG R + + Q D+ +
Sbjct: 342 NAPELTM---STLSSPTPENAPETVVA-VFSVSDPDSGDNG----RMICSIQNDLPFLLK 393
Query: 731 -AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
+ T+ TQ+ LDRE + Y +T+ + G + +T+ + D NDN P F
Sbjct: 394 PTLKNFYTLVTQRTLDRESQAEYNITITVT-DMGTPRLKTEHNITVLVSDVNDNAPAFTQ 452
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGK------EMFDVDENT 843
+Y F+ EN+ I + ATD D GTNA Y+L + ++ +
Sbjct: 453 TSYTLFVRENNSPALHI---GSVSATDRDSGTNAQVTYSLLPPQNPHLRLASLVSINADN 509
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
G + F SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 510 GHL-FALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDNSP 558
Score = 80.2 bits (189), Expect = 5e-14
Identities = 66/218 (30%), Positives = 101/218 (46%), Gaps = 24/218 (11%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN P+ + ++ ++A DLD+G G + Y + D EV + FVI+E+
Sbjct: 251 VPENSPLNSLVVVVSARDLDAGAYGSVAY----------ALFQGD--EVTQPFVIDEKTA 298
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFP-VFKKTWYNFNVEE 1056
+ + R+L E+ + + I A DGG L+ +V + V DVND+ P + T + E
Sbjct: 299 EIRLKRALDFEATPYYNVEIVATDGGGLSGKCTVAIEVVDVNDNAPELTMSTLSSPTPEN 358
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETE 1113
A T V+ +D D G N + IQ DLPF + P L LDRE++
Sbjct: 359 APET--VVAVFSVSDPDSGDNGRMICSIQ---NDLPFLLKPTLKNFYTLVTQRTLDRESQ 413
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
+Y +T+ D G DVNDN+P F
Sbjct: 414 AEYNITITVTDMG-TPRLKTEHNITVLVSDVNDNAPAF 450
Score = 79.8 bits (188), Expect = 7e-14
Identities = 123/520 (23%), Positives = 204/520 (39%), Gaps = 72/520 (13%)
Query: 917 TIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYI 976
T +++ N A + + L IPE+ GT A D D G N Y + +
Sbjct: 119 TDLQLTDINDHAPEFPEKEMLLKIPESTQPGTVFPLKIAQDFDIGSNTVQNYTISPNSHF 178
Query: 977 PPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVR 1032
+ + ++ +++ ++L E E L ++ALDGG + ++R
Sbjct: 179 HVATHNRGD---------GRKYPELVLDKALDREERPELSLTLTALDGGAPPRSGTTTIR 229
Query: 1033 VFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSDTDL 1091
+ V D ND+ P F +++Y V E ++ V A D D G ++ Y Q +
Sbjct: 230 IVVLDNNDNAPEFLQSFYEVQVPENSPLNSLVVVVSARDLDAGAYGSVAYALFQGDEVTQ 289
Query: 1092 PFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
PF I T + + LD E Y + +VA D G DVNDN+P+
Sbjct: 290 PFVIDEKTAEIRLKRALDFEATPYYNVEIVATDGG---GLSGKCTVAIEVVDVNDNAPEL 346
Query: 1152 YAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDF----- 1206
L PE + E+V + V+ + ++ G + + ND F
Sbjct: 347 TM--STLSSPTPE------NAPETV--VAVFSVSDPDSGDNGRMICSI-QNDLPFLLKPT 395
Query: 1207 IGNGNGLILYSLPQRKNQ---------QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVF 1257
+ N L+ R++Q ++G P L + + V V+DV D + P F
Sbjct: 396 LKNFYTLVTQRTLDRESQAEYNITITVTDMGTPRLKTEHNITVLVSDVND-----NAPAF 450
Query: 1258 ISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNG 1313
Y L + EN + + + S++ T+ N ++ Y +L + +R + I+ NG
Sbjct: 451 TQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQNPHLRLASLVSINADNG 510
Query: 1314 TLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDV 1373
L+ +RS D E +E V A R P + + V V + D
Sbjct: 511 HLFALRSLDYEALQAFEFRVGAT----DRGSPAL-------------SSEALVRVLVLDA 553
Query: 1374 NDNSP----KFTNGNRPLVTAIPTTAPFGYQVMQLKGAIG 1409
NDNSP NG+ P +P A GY V ++ G
Sbjct: 554 NDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDG 593
Score = 79.4 bits (187), Expect = 9e-14
Identities = 53/154 (34%), Positives = 79/154 (51%), Gaps = 9/154 (5%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
K LDRE+R +T+ A + G +G + I + D NDN P F + YE + ENS
Sbjct: 198 KALDREERPELSLTLTA-LDGGAPPRSGTTTIRIVVLDNNDNAPEFLQSFYEVQVPENSP 256
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM---FDVDENTGVVKFIGDSLDREKK 858
+ + + ++ A D D G Y LF +G E+ F +DE T ++ + +LD E
Sbjct: 257 LNSLVV---VVSARDLDAGAYGSVAYALF-QGDEVTQPFVIDEKTAEIR-LKRALDFEAT 311
Query: 859 IMYKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
Y + +VA D GGLS + + I + D NDN PE
Sbjct: 312 PYYNVEIVATDGGGLSGKCTVAIEVVDVNDNAPE 345
Score = 65.3 bits (152), Expect = 2e-09
Identities = 82/329 (24%), Positives = 136/329 (41%), Gaps = 29/329 (8%)
Query: 77 ISAYLSVTVYIEDVNDNVP-IFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVP 135
+S +V + + DVNDN P + + T T + T F G + + ++
Sbjct: 326 LSGKCTVAIEVVDVNDNAPELTMSTLSSPTPENAPETVVAVFSVSDPDSGDNGRMICSIQ 385
Query: 136 RGLTIF-----KDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLD 189
L K+ + S Y+I ++ D G L++ H +L+ V D
Sbjct: 386 NDLPFLLKPTLKNFYTLVTQRTLDRESQAEYNITITVTDMGTPRLKTEHNITVLVSDVND 445
Query: 190 YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLF 244
+ + + + L + A D+D G A + Y L+ + L
Sbjct: 446 NAPAFTQTSYTLFV--RENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQNPHLRLASLV 503
Query: 245 SLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLP 304
S+++ NG LF + LD +A LQA F +V A+ +P +++A V + +LD NDN P
Sbjct: 504 SINADNGHLFALRSLDYEA---LQA--FEFRVGATDRGSPALSSEALVRVLVLDANDNSP 558
Query: 305 EFEVDFYNIS--IVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDP 356
N S E +P G+ V +V+A D D G+N +YQL G FS+
Sbjct: 559 FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFSMWA 618
Query: 357 RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+G VR +L + R+ V K+
Sbjct: 619 HNG--EVRTARLLSERDAAKHRLVVLVKD 645
Score = 60.1 bits (139), Expect = 6e-08
Identities = 66/281 (23%), Positives = 109/281 (38%), Gaps = 16/281 (5%)
Query: 635 LSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSA 693
L R RP AL A S T + V+D ND L+ + V ENS
Sbjct: 200 LDREERPELSLTLTALDGGAPPRSGTTTIRIVVLDNNDNAPEFLQSFYE---VQVPENSP 256
Query: 694 GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED-GTIFTQKPLDREKRDVY 752
++ + + + G+V + + +VT I E I ++ LD E Y
Sbjct: 257 LNSL--VVVVSARDLDAGAYGSVAYALFQGDEVTQPFVIDEKTAEIRLKRALDFEATPYY 314
Query: 753 RMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNII 812
+ ++A G+ +G V I + D NDN P +T EN+ T + +
Sbjct: 315 NVEIVATDGGGL---SGKCTVAIEVVDVNDNAPELTMSTLSSPTPENAP-ETVVA---VF 367
Query: 813 KATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG 872
+D D G N + ++ + + +LDRE + Y +++ D G
Sbjct: 368 SVSDPDSGDNGRMICSIQNDLPFLLKPTLKNFYTLVTQRTLDRESQAEYNITITVTDMGT 427
Query: 873 --LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
L +E + +++ D NDN P F Q VR + L+
Sbjct: 428 PRLKTEHNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALH 468
Score = 59.7 bits (138), Expect = 8e-08
Identities = 59/200 (29%), Positives = 84/200 (42%), Gaps = 19/200 (9%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
LF+ N P I ++A D DSG N Q+ Y +PP L + IN
Sbjct: 457 LFVRENNSP-ALHIGSVSATDRDSGTNAQVTYSL-----LPPQN---PHLRLASLVSINA 507
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+GH+ RSL E+ F + A D G+ L+ VRV V D ND+ P N
Sbjct: 508 DNGHLFALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNG 567
Query: 1053 NVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
+ + R ++ KV A D D GQNA L+Y + + F + G +
Sbjct: 568 SAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFSMWAHNGEVRTAR 627
Query: 1107 ELDRETEDKYILTVVARDNG 1126
L K+ L V+ +DNG
Sbjct: 628 LLSERDAAKHRLVVLVKDNG 647
Score = 58.0 bits (134), Expect = 2e-07
Identities = 51/178 (28%), Positives = 79/178 (44%), Gaps = 11/178 (6%)
Query: 213 LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELD--LDAEHNLQAN 270
+FP I A D D+G Y + + + + + +G + E LD LD E + +
Sbjct: 151 VFPLKI-AQDFDIGSNTVQNYTISPNSHFHVATHNRGDGRKYPELVLDKALDREERPELS 209
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
L + A P ++ + I +LD NDN PEF FY + + EN P V+ V A
Sbjct: 210 ---LTLTALDGGAPPRSGTTTIRIVVLDNNDNAPEFLQSFYEVQVPENSPLNSLVVVVSA 266
Query: 331 TDKDQGENGEFTYQL---DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D D G G Y L D+ F ID ++ +R + LD EA +++ A +
Sbjct: 267 RDLDAGAYGSVAYALFQGDEVTQPFVIDEKTA--EIRLKRALDFEATPYYNVEIVATD 322
Score = 50.8 bits (116), Expect = 4e-05
Identities = 42/167 (25%), Positives = 76/167 (45%), Gaps = 13/167 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGND-RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D D G ++ Y L G++ + F +D + L++ LD +A N ++
Sbjct: 264 VSARDLDAGAYGSVAYALFQGDEVTQPFVIDEKTAEIRLKRALDFEATPYY--NVEIVAT 321
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA-TDKDQ 335
L+ + V IE++D+NDN PE + + EN P +V+ V + +D D
Sbjct: 322 DGGGLSG-----KCTVAIEVVDVNDNAPELTMSTLSSPTPENAPE--TVVAVFSVSDPDS 374
Query: 336 GENGEFTYQLDDPKGAFSIDPR-SGWLTVRNQTVLDREAHSSLRMKV 381
G+NG + + F + P + T+ Q LDRE+ + + +
Sbjct: 375 GDNGRMICSIQNDL-PFLLKPTLKNFYTLVTQRTLDRESQAEYNITI 420
Score = 45.6 bits (103), Expect = 0.001
Identities = 47/183 (25%), Positives = 77/183 (42%), Gaps = 13/183 (7%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G + + LDRE I F + + +Q + + D ND+ P F
Sbjct: 82 GNLLLYEKLDREVMCGATEPCILHFQLLLENPVQFFQTDLQLTDINDHAPEFPEKEMLLK 141
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVK-----FIG 850
I E+++ GT + A D D G+N + YT+ N G + +
Sbjct: 142 IPESTQPGTVFPLKI---AQDFDIGSNTVQNYTI-SPNSHFHVATHNRGDGRKYPELVLD 197
Query: 851 DSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRET 908
+LDRE++ L+L A D G S + I++ D NDN PEF ++ +V++ +
Sbjct: 198 KALDREERPELSLTLTALDGGAPPRSGTTTIRIVVLDNNDNAPEF--LQSFYEVQVPENS 255
Query: 909 KLN 911
LN
Sbjct: 256 PLN 258
Score = 41.5 bits (93), Expect = 0.022
Identities = 40/137 (29%), Positives = 61/137 (44%), Gaps = 7/137 (5%)
Query: 220 AIDQDLGVG--ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
A D LGVG AT + +++L LD G+L L ++LD + +L Q
Sbjct: 49 AKDLGLGVGELATRGARMHYKGNKELLQLDIKTGNLLLYEKLDREVMCGA-TEPCILHFQ 107
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
L NP++ Q +++L D+ND+ PEF + I E+ G +A D D G
Sbjct: 108 LL-LENPVQFFQT--DLQLTDINDHAPEFPEKEMLLKIPESTQPGTVFPLKIAQDFDIGS 164
Query: 338 NGEFTYQLDDPKGAFSI 354
N Y + P F +
Sbjct: 165 NTVQNYTI-SPNSHFHV 180
Score = 41.1 bits (92), Expect = 0.030
Identities = 39/126 (30%), Positives = 55/126 (43%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 540 LSSEALVRVLVLDANDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 598
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + + S + N T + S +H L V D P +L
Sbjct: 599 AWLSYQLLKATEPGLFSMWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 657
Query: 553 AVVTIE 558
V+ ++
Sbjct: 658 HVLLVD 663
>AB209393-1|BAD92630.1| 796|Homo sapiens protocadherin beta 5
precursor variant protein.
Length = 796
Score = 115 bits (277), Expect = 1e-24
Identities = 122/470 (25%), Positives = 199/470 (42%), Gaps = 37/470 (7%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E + F ++ L D ND+ P F P + + + GTV A D D+G N +
Sbjct: 112 ENPVQFFQTDLQLTDINDHAPEF-PEKEMLLKIPESTQPGTVFPLKIAQDFDIGSNTVQN 170
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI-LEGRH--ALFVEASDQPANPSERRYSLA 553
Y + S+ + + + + V + + E R +L + A D A P ++
Sbjct: 171 YTISPNSHFHVATHNRGDGRKYPELVLDKALDREERPELSLTLTALDGGAPPRSGTTTIR 230
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLL 611
+V ++ N + P+F+ + YE V N + + V + D A V+Y L
Sbjct: 231 IVVLD-------NNDNAPEFLQSFYEVQVPENSPLNSLVVVVSARDLDAGAYGSVAYALF 283
Query: 612 HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVND 671
G E PF ++E++ I + L P Y+ E VA + LS + VVDVND
Sbjct: 284 QGDEVTQPFVIDEKTAEIRLKRALDFEATPYYNVEIVAT-DGGGLSGKCTVAIEVVDVND 342
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI- 730
L S + EN+ + +F + NG R + + Q D+ +
Sbjct: 343 NAPELTM---STLSSPTPENAPETVVA-VFSVSDPDSGDNG----RMICSIQNDLPFLLK 394
Query: 731 -AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
+ T+ TQ+ LDRE + Y +T+ + G + +T+ + D NDN P F
Sbjct: 395 PTLKNFYTLVTQRTLDRESQAEYNITITVT-DMGTPRLKTEHNITVLVSDVNDNAPAFTQ 453
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGK------EMFDVDENT 843
+Y F+ EN+ I + ATD D GTNA Y+L + ++ +
Sbjct: 454 TSYTLFVRENNSPALHI---GSVSATDRDSGTNAQVTYSLLPPQNPHLRLASLVSINADN 510
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
G + F SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 511 GHL-FALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDNSP 559
Score = 80.2 bits (189), Expect = 5e-14
Identities = 66/218 (30%), Positives = 101/218 (46%), Gaps = 24/218 (11%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN P+ + ++ ++A DLD+G G + Y + D EV + FVI+E+
Sbjct: 252 VPENSPLNSLVVVVSARDLDAGAYGSVAY----------ALFQGD--EVTQPFVIDEKTA 299
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFP-VFKKTWYNFNVEE 1056
+ + R+L E+ + + I A DGG L+ +V + V DVND+ P + T + E
Sbjct: 300 EIRLKRALDFEATPYYNVEIVATDGGGLSGKCTVAIEVVDVNDNAPELTMSTLSSPTPEN 359
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETE 1113
A T V+ +D D G N + IQ DLPF + P L LDRE++
Sbjct: 360 APET--VVAVFSVSDPDSGDNGRMICSIQ---NDLPFLLKPTLKNFYTLVTQRTLDRESQ 414
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
+Y +T+ D G DVNDN+P F
Sbjct: 415 AEYNITITVTDMG-TPRLKTEHNITVLVSDVNDNAPAF 451
Score = 79.8 bits (188), Expect = 7e-14
Identities = 123/520 (23%), Positives = 204/520 (39%), Gaps = 72/520 (13%)
Query: 917 TIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYI 976
T +++ N A + + L IPE+ GT A D D G N Y + +
Sbjct: 120 TDLQLTDINDHAPEFPEKEMLLKIPESTQPGTVFPLKIAQDFDIGSNTVQNYTISPNSHF 179
Query: 977 PPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVR 1032
+ + ++ +++ ++L E E L ++ALDGG + ++R
Sbjct: 180 HVATHNRGD---------GRKYPELVLDKALDREERPELSLTLTALDGGAPPRSGTTTIR 230
Query: 1033 VFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSDTDL 1091
+ V D ND+ P F +++Y V E ++ V A D D G ++ Y Q +
Sbjct: 231 IVVLDNNDNAPEFLQSFYEVQVPENSPLNSLVVVVSARDLDAGAYGSVAYALFQGDEVTQ 290
Query: 1092 PFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
PF I T + + LD E Y + +VA D G DVNDN+P+
Sbjct: 291 PFVIDEKTAEIRLKRALDFEATPYYNVEIVATDGG---GLSGKCTVAIEVVDVNDNAPEL 347
Query: 1152 YAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDF----- 1206
L PE + E+V + V+ + ++ G + + ND F
Sbjct: 348 TM--STLSSPTPE------NAPETV--VAVFSVSDPDSGDNGRMICSI-QNDLPFLLKPT 396
Query: 1207 IGNGNGLILYSLPQRKNQ---------QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVF 1257
+ N L+ R++Q ++G P L + + V V+DV D + P F
Sbjct: 397 LKNFYTLVTQRTLDRESQAEYNITITVTDMGTPRLKTEHNITVLVSDVND-----NAPAF 451
Query: 1258 ISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNG 1313
Y L + EN + + + S++ T+ N ++ Y +L + +R + I+ NG
Sbjct: 452 TQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQNPHLRLASLVSINADNG 511
Query: 1314 TLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDV 1373
L+ +RS D E +E V A R P + + V V + D
Sbjct: 512 HLFALRSLDYEALQAFEFRVGAT----DRGSPAL-------------SSEALVRVLVLDA 554
Query: 1374 NDNSP----KFTNGNRPLVTAIPTTAPFGYQVMQLKGAIG 1409
NDNSP NG+ P +P A GY V ++ G
Sbjct: 555 NDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDG 594
Score = 79.4 bits (187), Expect = 9e-14
Identities = 53/154 (34%), Positives = 79/154 (51%), Gaps = 9/154 (5%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
K LDRE+R +T+ A + G +G + I + D NDN P F + YE + ENS
Sbjct: 199 KALDREERPELSLTLTA-LDGGAPPRSGTTTIRIVVLDNNDNAPEFLQSFYEVQVPENSP 257
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM---FDVDENTGVVKFIGDSLDREKK 858
+ + + ++ A D D G Y LF +G E+ F +DE T ++ + +LD E
Sbjct: 258 LNSLVV---VVSARDLDAGAYGSVAYALF-QGDEVTQPFVIDEKTAEIR-LKRALDFEAT 312
Query: 859 IMYKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
Y + +VA D GGLS + + I + D NDN PE
Sbjct: 313 PYYNVEIVATDGGGLSGKCTVAIEVVDVNDNAPE 346
Score = 65.3 bits (152), Expect = 2e-09
Identities = 82/329 (24%), Positives = 136/329 (41%), Gaps = 29/329 (8%)
Query: 77 ISAYLSVTVYIEDVNDNVP-IFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVP 135
+S +V + + DVNDN P + + T T + T F G + + ++
Sbjct: 327 LSGKCTVAIEVVDVNDNAPELTMSTLSSPTPENAPETVVAVFSVSDPDSGDNGRMICSIQ 386
Query: 136 RGLTIF-----KDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLD 189
L K+ + S Y+I ++ D G L++ H +L+ V D
Sbjct: 387 NDLPFLLKPTLKNFYTLVTQRTLDRESQAEYNITITVTDMGTPRLKTEHNITVLVSDVND 446
Query: 190 YDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLF 244
+ + + + L + A D+D G A + Y L+ + L
Sbjct: 447 NAPAFTQTSYTLFV--RENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQNPHLRLASLV 504
Query: 245 SLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLP 304
S+++ NG LF + LD +A LQA F +V A+ +P +++A V + +LD NDN P
Sbjct: 505 SINADNGHLFALRSLDYEA---LQA--FEFRVGATDRGSPALSSEALVRVLVLDANDNSP 559
Query: 305 EFEVDFYNIS--IVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDP 356
N S E +P G+ V +V+A D D G+N +YQL G FS+
Sbjct: 560 FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFSMWA 619
Query: 357 RSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+G VR +L + R+ V K+
Sbjct: 620 HNG--EVRTARLLSERDAAKHRLVVLVKD 646
Score = 60.1 bits (139), Expect = 6e-08
Identities = 66/281 (23%), Positives = 109/281 (38%), Gaps = 16/281 (5%)
Query: 635 LSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSA 693
L R RP AL A S T + V+D ND L+ + V ENS
Sbjct: 201 LDREERPELSLTLTALDGGAPPRSGTTTIRIVVLDNNDNAPEFLQSFYE---VQVPENSP 257
Query: 694 GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED-GTIFTQKPLDREKRDVY 752
++ + + + G+V + + +VT I E I ++ LD E Y
Sbjct: 258 LNSL--VVVVSARDLDAGAYGSVAYALFQGDEVTQPFVIDEKTAEIRLKRALDFEATPYY 315
Query: 753 RMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNII 812
+ ++A G+ +G V I + D NDN P +T EN+ T + +
Sbjct: 316 NVEIVATDGGGL---SGKCTVAIEVVDVNDNAPELTMSTLSSPTPENAP-ETVVA---VF 368
Query: 813 KATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG 872
+D D G N + ++ + + +LDRE + Y +++ D G
Sbjct: 369 SVSDPDSGDNGRMICSIQNDLPFLLKPTLKNFYTLVTQRTLDRESQAEYNITITVTDMGT 428
Query: 873 --LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
L +E + +++ D NDN P F Q VR + L+
Sbjct: 429 PRLKTEHNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALH 469
Score = 59.7 bits (138), Expect = 8e-08
Identities = 59/200 (29%), Positives = 84/200 (42%), Gaps = 19/200 (9%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
LF+ N P I ++A D DSG N Q+ Y +PP L + IN
Sbjct: 458 LFVRENNSP-ALHIGSVSATDRDSGTNAQVTYSL-----LPPQN---PHLRLASLVSINA 508
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+GH+ RSL E+ F + A D G+ L+ VRV V D ND+ P N
Sbjct: 509 DNGHLFALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNG 568
Query: 1053 NVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
+ + R ++ KV A D D GQNA L+Y + + F + G +
Sbjct: 569 SAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFSMWAHNGEVRTAR 628
Query: 1107 ELDRETEDKYILTVVARDNG 1126
L K+ L V+ +DNG
Sbjct: 629 LLSERDAAKHRLVVLVKDNG 648
Score = 58.0 bits (134), Expect = 2e-07
Identities = 51/178 (28%), Positives = 79/178 (44%), Gaps = 11/178 (6%)
Query: 213 LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELD--LDAEHNLQAN 270
+FP I A D D+G Y + + + + + +G + E LD LD E + +
Sbjct: 152 VFPLKI-AQDFDIGSNTVQNYTISPNSHFHVATHNRGDGRKYPELVLDKALDREERPELS 210
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
L + A P ++ + I +LD NDN PEF FY + + EN P V+ V A
Sbjct: 211 ---LTLTALDGGAPPRSGTTTIRIVVLDNNDNAPEFLQSFYEVQVPENSPLNSLVVVVSA 267
Query: 331 TDKDQGENGEFTYQL---DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D D G G Y L D+ F ID ++ +R + LD EA +++ A +
Sbjct: 268 RDLDAGAYGSVAYALFQGDEVTQPFVIDEKTA--EIRLKRALDFEATPYYNVEIVATD 323
Score = 50.8 bits (116), Expect = 4e-05
Identities = 42/167 (25%), Positives = 76/167 (45%), Gaps = 13/167 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGND-RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D D G ++ Y L G++ + F +D + L++ LD +A N ++
Sbjct: 265 VSARDLDAGAYGSVAYALFQGDEVTQPFVIDEKTAEIRLKRALDFEATPYY--NVEIVAT 322
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA-TDKDQ 335
L+ + V IE++D+NDN PE + + EN P +V+ V + +D D
Sbjct: 323 DGGGLSG-----KCTVAIEVVDVNDNAPELTMSTLSSPTPENAPE--TVVAVFSVSDPDS 375
Query: 336 GENGEFTYQLDDPKGAFSIDPR-SGWLTVRNQTVLDREAHSSLRMKV 381
G+NG + + F + P + T+ Q LDRE+ + + +
Sbjct: 376 GDNGRMICSIQNDL-PFLLKPTLKNFYTLVTQRTLDRESQAEYNITI 421
Score = 45.6 bits (103), Expect = 0.001
Identities = 47/183 (25%), Positives = 77/183 (42%), Gaps = 13/183 (7%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G + + LDRE I F + + +Q + + D ND+ P F
Sbjct: 83 GNLLLYEKLDREVMCGATEPCILHFQLLLENPVQFFQTDLQLTDINDHAPEFPEKEMLLK 142
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVK-----FIG 850
I E+++ GT + A D D G+N + YT+ N G + +
Sbjct: 143 IPESTQPGTVFPLKI---AQDFDIGSNTVQNYTI-SPNSHFHVATHNRGDGRKYPELVLD 198
Query: 851 DSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRET 908
+LDRE++ L+L A D G S + I++ D NDN PEF ++ +V++ +
Sbjct: 199 KALDREERPELSLTLTALDGGAPPRSGTTTIRIVVLDNNDNAPEF--LQSFYEVQVPENS 256
Query: 909 KLN 911
LN
Sbjct: 257 PLN 259
Score = 41.5 bits (93), Expect = 0.022
Identities = 40/137 (29%), Positives = 61/137 (44%), Gaps = 7/137 (5%)
Query: 220 AIDQDLGVG--ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
A D LGVG AT + +++L LD G+L L ++LD + +L Q
Sbjct: 50 AKDLGLGVGELATRGARMHYKGNKELLQLDIKTGNLLLYEKLDREVMCGA-TEPCILHFQ 108
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
L NP++ Q +++L D+ND+ PEF + I E+ G +A D D G
Sbjct: 109 LL-LENPVQFFQT--DLQLTDINDHAPEFPEKEMLLKIPESTQPGTVFPLKIAQDFDIGS 165
Query: 338 NGEFTYQLDDPKGAFSI 354
N Y + P F +
Sbjct: 166 NTVQNYTI-SPNSHFHV 181
Score = 41.1 bits (92), Expect = 0.030
Identities = 39/126 (30%), Positives = 55/126 (43%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 541 LSSEALVRVLVLDANDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 599
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + + S + N T + S +H L V D P +L
Sbjct: 600 AWLSYQLLKATEPGLFSMWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 658
Query: 553 AVVTIE 558
V+ ++
Sbjct: 659 HVLLVD 664
>AY358946-1|AAQ89305.1| 916|Homo sapiens cadherin FIB3 protein.
Length = 916
Score = 114 bits (274), Expect = 3e-24
Identities = 122/476 (25%), Positives = 203/476 (42%), Gaps = 33/476 (6%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
N++ E + VEV + D NDN P F S L E + NA A DPD+G
Sbjct: 105 NLDILMEDKVKIYGVEVEVRDINDNAPYFRESEL-EIKISENAATEMRFPLPHAWDPDIG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSE 547
+N + Y+L ++ ++ + + V + + + H L + ASD +P
Sbjct: 164 KNSLQSYELSPNTHFSLIVQNGADGSKYPELVLKRALDREEKAAHHLVLTASDG-GDPV- 221
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QND 605
R A + + V + P F Y V N+ +GT + + D E +
Sbjct: 222 -RTGTARIRVMVLDAND----NAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGVNAE 276
Query: 606 VSYDLLHGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
V Y + ++ F ++ SG I+ + +L Y E A+ +NA S +
Sbjct: 277 VRYSFRYVDDKAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAM-DNAGYSARAKVLI 335
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
V+DVND ++ + + V ENS + + + N NG V I
Sbjct: 336 TVLDVNDNAPEVVL---TSLASSVPENSPRGTLIALLNVNDQDSEENG--QVICFIQGNL 390
Query: 725 DVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
+ + ++ T LDRE+ Y +TV A ++G + +++ + D NDNP
Sbjct: 391 PFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTAT-DRGTPPLSTETHISLNVADTNDNP 449
Query: 785 PVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEM---FD 838
PVF A+Y +I EN+ G + + A D D NA Y+L +G +
Sbjct: 450 PVFPQASYSAYIPENNPRGVSLVS---VTAHDPDCEENAQITYSLAENTIQGASLSSYVS 506
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPE 892
++ +TGV+ + S D E+ ++ ++ARD G LSS L + + D+NDN PE
Sbjct: 507 INSDTGVL-YALSSFDYEQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPE 561
Score = 85.0 bits (201), Expect = 2e-15
Identities = 108/456 (23%), Positives = 195/456 (42%), Gaps = 32/456 (7%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
+ V +LDANDN P F Y S+ N +GT + V A DPD G N V Y + +
Sbjct: 228 IRVMVLDANDNAPAFAQPE-YRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDD 286
Query: 505 LTITSPFKINPNTGTVS-VAESPILE-GRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
FK++ N+GT+S + E E G + + V+A D + + + V+ +
Sbjct: 287 -KAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDNAGYSARAKVLITVLDV----- 340
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAV 622
+ P+ + V N GT + + VND + ++ + ++ + +PF +
Sbjct: 341 ----NDNAPEVVLTSLASSVPENSPRGTLIALLNVND--QDSEENGQVICFIQGNLPFKL 394
Query: 623 EERSG-VITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLLK 678
E+ G ++V D L R P Y+ A LS T+ +++V D ND V +
Sbjct: 395 EKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQ 454
Query: 679 GAHSPIIFHVKENSAGAAIGQI-FHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED-G 736
++S I + N G ++ + H T ++ ++ ++I D G
Sbjct: 455 ASYSAYI--PENNPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTG 512
Query: 737 TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP--VFEHATYEG 794
++ D E+ ++ V+A N + + +++++ D+NDN P ++ +G
Sbjct: 513 VLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNV-SLSLFVLDQNDNAPEILYPALPTDG 571
Query: 795 FI-MENSKIGTEI-KMDNIIKATDADEGTNALFMYTLFGEGKE-MFDVDENTGVVKFIGD 851
+E + E + + A D D G NA Y L + +F V +TG V+
Sbjct: 572 STGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARA 631
Query: 852 SLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
LDR+ + L + +D G LS+ L + + D
Sbjct: 632 LLDRD-ALKQSLVVAVQDHGQPPLSATVTLTVAVAD 666
Score = 84.6 bits (200), Expect = 2e-15
Identities = 65/195 (33%), Positives = 95/195 (48%), Gaps = 9/195 (4%)
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLF 254
+E +L I S + E+ FP P HA D D+G + YEL L + +GS +
Sbjct: 134 RESELEIKIS-ENAATEMRFPLP-HAWDPDIGKNSLQSYELSPNTHFSLIVQNGADGSKY 191
Query: 255 LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNIS 314
E L + +A L + AS +P++T AR+ + +LD NDN P F Y S
Sbjct: 192 PELVLKRALDREEKA-AHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRAS 250
Query: 315 IVENLPNGFSVLQVMATDKDQGENGE--FTYQLDDPKGA--FSIDPRSGWLTVRNQTVLD 370
+ ENL G +L V ATD D+G N E ++++ D K A F +D SG T+ LD
Sbjct: 251 VPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSG--TISTIGELD 308
Query: 371 REAHSSLRMKVYAKE 385
E +M+V A +
Sbjct: 309 HEESGFYQMEVQAMD 323
Score = 73.3 bits (172), Expect = 6e-12
Identities = 77/290 (26%), Positives = 117/290 (40%), Gaps = 48/290 (16%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN+ +GT ++ +NA D D G+N ++RY F Y+ + + F ++ G
Sbjct: 251 VPENLALGTQLLVVNATDPDEGVNAEVRYSFR---YVDD--------KAAQVFKLDCNSG 299
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ L E +++ + A+D + V + V DVND+ P T +V E
Sbjct: 300 TISTIGELDHEESGFYQMEVQAMDNAGYSARAKVLITVLDVNDNAPEVVLTSLASSVPEN 359
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
++ ++ D D +N + FIQ +LPF++ G L + LDRE
Sbjct: 360 SPRGTLIALLNVNDQDSEENGQVICFIQ---GNLPFKLEKSYGNYYSLVTDIVLDREQVP 416
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFE 1174
Y +TV A D G D NDN P F P+A
Sbjct: 417 SYNITVTATDRG-TPPLSTETHISLNVADTNDNPPVF-----------PQAS-------- 456
Query: 1175 SVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQ 1224
Y A I EN P G ++ V A+D D N I YSL + Q
Sbjct: 457 -------YSAYIPENNPRGVSLVSVTAHDPDC--EENAQITYSLAENTIQ 497
Score = 70.5 bits (165), Expect = 4e-11
Identities = 91/355 (25%), Positives = 142/355 (40%), Gaps = 26/355 (7%)
Query: 997 RHGHVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
++ +++ R+L E + L ++A DGG+ +RV V D ND+ P F + Y
Sbjct: 190 KYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRA 249
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP--FEISPLTGVLSVNGELDR 1110
+V E L V+ATD D G NA + Y + D F++ +G +S GELD
Sbjct: 250 SVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGTISTIGELDH 309
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK--FYAFDELLEWKHPEAD-- 1166
E Y + V A DN DVNDN+P+ + + P
Sbjct: 310 EESGFYQMEVQAMDN---AGYSARAKVLITVLDVNDNAPEVVLTSLASSVPENSPRGTLI 366
Query: 1167 ELSNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQ 1224
L N N + I+ N P + + ++ TD + + + Y++
Sbjct: 367 ALLNVNDQDSEENGQVICFIQGNLPFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATD 426
Query: 1225 QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL--T 1282
+ G P LS+ + + VAD D + PVF Y I EN V LVS+
Sbjct: 427 R--GTPPLSTETHISLNVADTND-----NPPVFPQASYSAYIPENNPRGVSLVSVTAHDP 479
Query: 1283 EHYENFKMRYYILNE--NDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
+ EN ++ Y + + I+ G LY + S D E +V V A
Sbjct: 480 DCEENAQITYSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMA 534
Score = 69.3 bits (162), Expect = 1e-10
Identities = 107/396 (27%), Positives = 169/396 (42%), Gaps = 49/396 (12%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
GTI T LD E+ Y+M V A N G + A +V I + D NDN P +
Sbjct: 299 GTISTIGELDHEESGFYQMEVQAMDNAGYSARA---KVLITVLDVNDNAPEVVLTSLASS 355
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTG-VVKFIGDS-L 853
+ ENS GT I + N+ D D N + F +G F ++++ G + D L
Sbjct: 356 VPENSPRGTLIALLNV---NDQDSEENGQVI--CFIQGNLPFKLEKSYGNYYSLVTDIVL 410
Query: 854 DREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
DRE+ Y +++ A D G LS+E + + + D NDN P F Q ++ + N
Sbjct: 411 DREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYI------PEN 464
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
G +++ V + + Q+ + + EN G ++ +++ D+G + Y +
Sbjct: 465 NPRGVSLVSVTAHDPDCEENAQI--TYSLAENTIQGASLSSYVSINSDTG----VLYALS 518
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISV 1031
S Y + D L+VK V+ +GH P S L++ LD NDN
Sbjct: 519 SFDY----EQFRD-LQVK---VMARDNGHP------PLSSNVSLSLFVLD---QNDNAPE 561
Query: 1032 RVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDL 1091
++ P T A+ ++ KV A D D GQNA L+Y + +
Sbjct: 562 ILY-----PALPTDGSTGVELAPRSAE-PGYLVTKVVAVDRDSGQNAWLSYRLLKASEPG 615
Query: 1092 PFEISPLTG-VLSVNGELDRETEDKYILTVVARDNG 1126
F + TG V + LDR+ K L V +D+G
Sbjct: 616 LFSVGLHTGEVRTARALLDRDAL-KQSLVVAVQDHG 650
Score = 66.5 bits (155), Expect = 7e-10
Identities = 52/179 (29%), Positives = 90/179 (50%), Gaps = 11/179 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR--KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
++A D D GV A +RY +D+ ++F LD +G++ ELD + ++ + ++
Sbjct: 264 VNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGTISTIGELDHE-----ESGFYQME 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
VQA ++N +A+A+V I +LD+NDN PE + S+ EN P G + + D+D
Sbjct: 319 VQA--MDNAGYSARAKVLITVLDVNDNAPEVVLTSLASSVPENSPRGTLIALLNVNDQDS 376
Query: 336 GENGEFTYQLDDPKGAFSIDPRSG-WLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
ENG+ + F ++ G + ++ VLDRE S + V A + + T
Sbjct: 377 EENGQVICFIQG-NLPFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLST 434
Score = 62.9 bits (146), Expect = 9e-09
Identities = 63/218 (28%), Positives = 91/218 (41%), Gaps = 19/218 (8%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN P GT I LN D DS NGQ+ + P KL Y ++ +
Sbjct: 356 VPENSPRGTLIALLNVNDQDSEENGQVICFIQGNL---PFKLEKSYGNY--YSLVTD--- 407
Query: 1000 HVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+++ R P + + ++A D G L+ + + V D ND+ PVF + Y+ + E
Sbjct: 408 -IVLDREQVPS--YNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPEN 464
Query: 1058 QYTRRVLGKVDATDADFGQNANLTY-----FIQPSDTDLPFEISPLTGVLSVNGELDRET 1112
L V A D D +NA +TY IQ + I+ TGVL D E
Sbjct: 465 NPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQ 524
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
+ V+ARDNG D NDN+P+
Sbjct: 525 FRDLQVKVMARDNG-HPPLSSNVSLSLFVLDQNDNAPE 561
Score = 58.4 bits (135), Expect = 2e-07
Identities = 52/175 (29%), Positives = 79/175 (45%), Gaps = 13/175 (7%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVI--SGAGIYQVTIYIEDENDNPPVFEHATYE 793
G++ T +DRE ++ + + N ++ IY V + + D NDN P F + E
Sbjct: 82 GSLVTAGRIDRE--ELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPYFRESELE 139
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----I 849
I EN+ TE++ + A D D G N+L Y L V K+ +
Sbjct: 140 IKISENA--ATEMRFP-LPHAWDPDIGKNSLQSYELSPNTHFSLIVQNGADGSKYPELVL 196
Query: 850 GDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKV 902
+LDRE+K + L L A D G + A + +M+ D NDN P F Q E + V
Sbjct: 197 KRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRASV 251
Score = 56.4 bits (130), Expect = 7e-07
Identities = 94/386 (24%), Positives = 154/386 (39%), Gaps = 37/386 (9%)
Query: 21 LFTYRDLNRTHVSVILAQSIDSLVDSDSPQNVVKFRLGCDFDEGDDLVRIGA-GLNQI-S 78
L +Y TH S+I+ D S P+ V+K L + LV + G + + +
Sbjct: 167 LQSYELSPNTHFSLIVQNGADG---SKYPELVLKRALDREEKAAHHLVLTASDGGDPVRT 223
Query: 79 AYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGL 138
+ V + D NDN P F Y +V E G + + + +
Sbjct: 224 GTARIRVMVLDANDNAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRY 283
Query: 139 TIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALE---------SSHKPVLLLRKVLD 189
K + F D + S + + + G + +E S+ VL+ VLD
Sbjct: 284 VDDKAAQVFKLDCNSGTISTI--GELDHEESGFYQMEVQAMDNAGYSARAKVLIT--VLD 339
Query: 190 YDAGDKEFQLVIMASG--KRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLD 247
+ E L +AS + + L ++ DQD + I GN F L+
Sbjct: 340 VNDNAPEVVLTSLASSVPENSPRGTLIAL-LNVNDQDSEENGQVIC-FIQGN--LPFKLE 395
Query: 248 SVNGSLF-LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF 306
G+ + L ++ LD E Q ++ + V A+ P + + + + + D NDN P F
Sbjct: 396 KSYGNYYSLVTDIVLDRE---QVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVF 452
Query: 307 EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDP--KGA-----FSIDPRSG 359
Y+ I EN P G S++ V A D D EN + TY L + +GA SI+ +G
Sbjct: 453 PQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTG 512
Query: 360 WLTVRNQTVLDREAHSSLRMKVYAKE 385
L + D E L++KV A++
Sbjct: 513 VLYALSS--FDYEQFRDLQVKVMARD 536
Score = 44.0 bits (99), Expect = 0.004
Identities = 42/170 (24%), Positives = 68/170 (40%), Gaps = 12/170 (7%)
Query: 992 FVINERHGHVIVARSLPPES------EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVF 1045
F +N R G ++ A + E + +LN+ L + V V V+D+ND+ P F
Sbjct: 75 FALNPRSGSLVTAGRIDREELCMGAIKCQLNLDILMEDKVKI-YGVEVEVRDINDNAPYF 133
Query: 1046 KKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG----V 1101
+++ + E T A D D G+N+ +Y + P+ + G
Sbjct: 134 RESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSPNTHFSLIVQNGADGSKYPE 193
Query: 1102 LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
L + LDRE + + L + A D G D NDN+P F
Sbjct: 194 LVLKRALDREEKAAHHLVLTASDGG-DPVRTGTARIRVMVLDANDNAPAF 242
Score = 43.6 bits (98), Expect = 0.006
Identities = 46/170 (27%), Positives = 77/170 (45%), Gaps = 20/170 (11%)
Query: 218 IHAIDQDLGVGATLRYEL----ISGNDRKLF-SLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A D D A + Y L I G + S++S G L+ D + +LQ
Sbjct: 474 VTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQ---- 529
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLPN----GFSV 325
++V A +P ++ + + +LD NDN PE + + VE P G+ V
Sbjct: 530 -VKVMARDNGHPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLV 588
Query: 326 LQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREA 373
+V+A D+D G+N +Y+L G FS+ +G + + +LDR+A
Sbjct: 589 TKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTA-RALLDRDA 637
Score = 39.9 bits (89), Expect = 0.069
Identities = 41/143 (28%), Positives = 60/143 (41%), Gaps = 9/143 (6%)
Query: 221 IDQDLGVG----ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
I +DLG+ A +I +LF+L+ +GSL +D + L Q+
Sbjct: 48 ISRDLGLEPRELAERGVRIIPRGRTQLFALNPRSGSLVTAGRIDRE---ELCMGAIKCQL 104
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
L K VE+E+ D+NDN P F I I EN A D D G
Sbjct: 105 NLDILMED-KVKIYGVEVEVRDINDNAPYFRESELEIKISENAATEMRFPLPHAWDPDIG 163
Query: 337 ENGEFTYQLDDPKGAFSIDPRSG 359
+N +Y+L P FS+ ++G
Sbjct: 164 KNSLQSYEL-SPNTHFSLIVQNG 185
Score = 39.9 bits (89), Expect = 0.069
Identities = 44/174 (25%), Positives = 74/174 (42%), Gaps = 31/174 (17%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P + TA + V V D D P F Y + EN+ +L+ +N T+ E
Sbjct: 218 GDPVRTGTARIRVMVLDANDNA-----PAFAQPEYRASVPENLALGTQLLVVNATDPDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA-ERQKYSREL 1344
N ++RY +D + F +D +GT+ + D E Y++ V+A + YS
Sbjct: 273 VNAEVRYSFRYVDDK-AAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDNAGYSAR- 330
Query: 1345 PHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFG 1398
KV++ + DVNDN+P+ + L +++P +P G
Sbjct: 331 -------------------AKVLITVLDVNDNAPEVVLTS--LASSVPENSPRG 363
Score = 39.1 bits (87), Expect = 0.12
Identities = 38/129 (29%), Positives = 59/129 (45%), Gaps = 13/129 (10%)
Query: 439 LMSFVNVEVTLLDANDNNP-VFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPDLGQ 491
L S V++ + +LD NDN P + P S E + +S A+ G ++ KV AVD D GQ
Sbjct: 542 LSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRS-AEPGYLVTKVVAVDRDSGQ 600
Query: 492 NGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERR 549
N + Y L + S + F + +TG V A + + + +L V D P
Sbjct: 601 NAWLSYRLLKASEPGL---FSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSAT 657
Query: 550 YSLAVVTIE 558
+L V +
Sbjct: 658 VTLTVAVAD 666
>AF152506-1|AAD43767.1| 820|Homo sapiens protocadherin gamma A12
short form protein protein.
Length = 820
Score = 114 bits (274), Expect = 3e-24
Identities = 122/476 (25%), Positives = 203/476 (42%), Gaps = 33/476 (6%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
N++ E + VEV + D NDN P F S L E + NA A DPD+G
Sbjct: 105 NLDILMEDKVKIYGVEVEVRDINDNAPYFRESEL-EIKISENAATEMRFPLPHAWDPDIG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSE 547
+N + Y+L ++ ++ + + V + + + H L + ASD +P
Sbjct: 164 KNSLQSYELSPNTHFSLIVQNGADGSKYPELVLKRALDREEKAAHHLVLTASDG-GDPV- 221
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QND 605
R A + + V + P F Y V N+ +GT + + D E +
Sbjct: 222 -RTGTARIRVMVLDAND----NAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGVNAE 276
Query: 606 VSYDLLHGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
V Y + ++ F ++ SG I+ + +L Y E A+ +NA S +
Sbjct: 277 VRYSFRYVDDKAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAM-DNAGYSARAKVLI 335
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
V+DVND ++ + + V ENS + + + N NG V I
Sbjct: 336 TVLDVNDNAPEVVL---TSLASSVPENSPRGTLIALLNVNDQDSEENG--QVICFIQGNL 390
Query: 725 DVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
+ + ++ T LDRE+ Y +TV A ++G + +++ + D NDNP
Sbjct: 391 PFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTAT-DRGTPPLSTETHISLNVADTNDNP 449
Query: 785 PVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEM---FD 838
PVF A+Y +I EN+ G + + A D D NA Y+L +G +
Sbjct: 450 PVFPQASYSAYIPENNPRGVSLVS---VTAHDPDCEENAQITYSLAENTIQGASLSSYVS 506
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPE 892
++ +TGV+ + S D E+ ++ ++ARD G LSS L + + D+NDN PE
Sbjct: 507 INSDTGVL-YALSSFDYEQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPE 561
Score = 85.0 bits (201), Expect = 2e-15
Identities = 108/456 (23%), Positives = 195/456 (42%), Gaps = 32/456 (7%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
+ V +LDANDN P F Y S+ N +GT + V A DPD G N V Y + +
Sbjct: 228 IRVMVLDANDNAPAFAQPE-YRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDD 286
Query: 505 LTITSPFKINPNTGTVS-VAESPILE-GRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
FK++ N+GT+S + E E G + + V+A D + + + V+ +
Sbjct: 287 -KAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDNAGYSARAKVLITVLDV----- 340
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAV 622
+ P+ + V N GT + + VND + ++ + ++ + +PF +
Sbjct: 341 ----NDNAPEVVLTSLASSVPENSPRGTLIALLNVND--QDSEENGQVICFIQGNLPFKL 394
Query: 623 EERSG-VITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLLK 678
E+ G ++V D L R P Y+ A LS T+ +++V D ND V +
Sbjct: 395 EKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQ 454
Query: 679 GAHSPIIFHVKENSAGAAIGQI-FHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED-G 736
++S I + N G ++ + H T ++ ++ ++I D G
Sbjct: 455 ASYSAYI--PENNPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTG 512
Query: 737 TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP--VFEHATYEG 794
++ D E+ ++ V+A N + + +++++ D+NDN P ++ +G
Sbjct: 513 VLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNV-SLSLFVLDQNDNAPEILYPALPTDG 571
Query: 795 FI-MENSKIGTEI-KMDNIIKATDADEGTNALFMYTLFGEGKE-MFDVDENTGVVKFIGD 851
+E + E + + A D D G NA Y L + +F V +TG V+
Sbjct: 572 STGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARA 631
Query: 852 SLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
LDR+ + L + +D G LS+ L + + D
Sbjct: 632 LLDRD-ALKQSLVVAVQDHGQPPLSATVTLTVAVAD 666
Score = 84.6 bits (200), Expect = 2e-15
Identities = 65/195 (33%), Positives = 95/195 (48%), Gaps = 9/195 (4%)
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLF 254
+E +L I S + E+ FP P HA D D+G + YEL L + +GS +
Sbjct: 134 RESELEIKIS-ENAATEMRFPLP-HAWDPDIGKNSLQSYELSPNTHFSLIVQNGADGSKY 191
Query: 255 LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNIS 314
E L + +A L + AS +P++T AR+ + +LD NDN P F Y S
Sbjct: 192 PELVLKRALDREEKA-AHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRAS 250
Query: 315 IVENLPNGFSVLQVMATDKDQGENGE--FTYQLDDPKGA--FSIDPRSGWLTVRNQTVLD 370
+ ENL G +L V ATD D+G N E ++++ D K A F +D SG T+ LD
Sbjct: 251 VPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSG--TISTIGELD 308
Query: 371 REAHSSLRMKVYAKE 385
E +M+V A +
Sbjct: 309 HEESGFYQMEVQAMD 323
Score = 73.3 bits (172), Expect = 6e-12
Identities = 77/290 (26%), Positives = 117/290 (40%), Gaps = 48/290 (16%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN+ +GT ++ +NA D D G+N ++RY F Y+ + + F ++ G
Sbjct: 251 VPENLALGTQLLVVNATDPDEGVNAEVRYSFR---YVDD--------KAAQVFKLDCNSG 299
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ L E +++ + A+D + V + V DVND+ P T +V E
Sbjct: 300 TISTIGELDHEESGFYQMEVQAMDNAGYSARAKVLITVLDVNDNAPEVVLTSLASSVPEN 359
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
++ ++ D D +N + FIQ +LPF++ G L + LDRE
Sbjct: 360 SPRGTLIALLNVNDQDSEENGQVICFIQ---GNLPFKLEKSYGNYYSLVTDIVLDREQVP 416
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFE 1174
Y +TV A D G D NDN P F P+A
Sbjct: 417 SYNITVTATDRG-TPPLSTETHISLNVADTNDNPPVF-----------PQAS-------- 456
Query: 1175 SVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQ 1224
Y A I EN P G ++ V A+D D N I YSL + Q
Sbjct: 457 -------YSAYIPENNPRGVSLVSVTAHDPDC--EENAQITYSLAENTIQ 497
Score = 70.5 bits (165), Expect = 4e-11
Identities = 91/355 (25%), Positives = 142/355 (40%), Gaps = 26/355 (7%)
Query: 997 RHGHVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
++ +++ R+L E + L ++A DGG+ +RV V D ND+ P F + Y
Sbjct: 190 KYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRA 249
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP--FEISPLTGVLSVNGELDR 1110
+V E L V+ATD D G NA + Y + D F++ +G +S GELD
Sbjct: 250 SVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGTISTIGELDH 309
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK--FYAFDELLEWKHPEAD-- 1166
E Y + V A DN DVNDN+P+ + + P
Sbjct: 310 EESGFYQMEVQAMDN---AGYSARAKVLITVLDVNDNAPEVVLTSLASSVPENSPRGTLI 366
Query: 1167 ELSNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQ 1224
L N N + I+ N P + + ++ TD + + + Y++
Sbjct: 367 ALLNVNDQDSEENGQVICFIQGNLPFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATD 426
Query: 1225 QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL--T 1282
+ G P LS+ + + VAD D + PVF Y I EN V LVS+
Sbjct: 427 R--GTPPLSTETHISLNVADTND-----NPPVFPQASYSAYIPENNPRGVSLVSVTAHDP 479
Query: 1283 EHYENFKMRYYILNE--NDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
+ EN ++ Y + + I+ G LY + S D E +V V A
Sbjct: 480 DCEENAQITYSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMA 534
Score = 69.3 bits (162), Expect = 1e-10
Identities = 107/396 (27%), Positives = 169/396 (42%), Gaps = 49/396 (12%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
GTI T LD E+ Y+M V A N G + A +V I + D NDN P +
Sbjct: 299 GTISTIGELDHEESGFYQMEVQAMDNAGYSARA---KVLITVLDVNDNAPEVVLTSLASS 355
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTG-VVKFIGDS-L 853
+ ENS GT I + N+ D D N + F +G F ++++ G + D L
Sbjct: 356 VPENSPRGTLIALLNV---NDQDSEENGQVI--CFIQGNLPFKLEKSYGNYYSLVTDIVL 410
Query: 854 DREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
DRE+ Y +++ A D G LS+E + + + D NDN P F Q ++ + N
Sbjct: 411 DREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYI------PEN 464
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
G +++ V + + Q+ + + EN G ++ +++ D+G + Y +
Sbjct: 465 NPRGVSLVSVTAHDPDCEENAQI--TYSLAENTIQGASLSSYVSINSDTG----VLYALS 518
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISV 1031
S Y + D L+VK V+ +GH P S L++ LD NDN
Sbjct: 519 SFDY----EQFRD-LQVK---VMARDNGHP------PLSSNVSLSLFVLD---QNDNAPE 561
Query: 1032 RVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDL 1091
++ P T A+ ++ KV A D D GQNA L+Y + +
Sbjct: 562 ILY-----PALPTDGSTGVELAPRSAE-PGYLVTKVVAVDRDSGQNAWLSYRLLKASEPG 615
Query: 1092 PFEISPLTG-VLSVNGELDRETEDKYILTVVARDNG 1126
F + TG V + LDR+ K L V +D+G
Sbjct: 616 LFSVGLHTGEVRTARALLDRDAL-KQSLVVAVQDHG 650
Score = 66.5 bits (155), Expect = 7e-10
Identities = 52/179 (29%), Positives = 90/179 (50%), Gaps = 11/179 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR--KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
++A D D GV A +RY +D+ ++F LD +G++ ELD + ++ + ++
Sbjct: 264 VNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGTISTIGELDHE-----ESGFYQME 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
VQA ++N +A+A+V I +LD+NDN PE + S+ EN P G + + D+D
Sbjct: 319 VQA--MDNAGYSARAKVLITVLDVNDNAPEVVLTSLASSVPENSPRGTLIALLNVNDQDS 376
Query: 336 GENGEFTYQLDDPKGAFSIDPRSG-WLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
ENG+ + F ++ G + ++ VLDRE S + V A + + T
Sbjct: 377 EENGQVICFIQG-NLPFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLST 434
Score = 62.9 bits (146), Expect = 9e-09
Identities = 63/218 (28%), Positives = 91/218 (41%), Gaps = 19/218 (8%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN P GT I LN D DS NGQ+ + P KL Y ++ +
Sbjct: 356 VPENSPRGTLIALLNVNDQDSEENGQVICFIQGNL---PFKLEKSYGNY--YSLVTD--- 407
Query: 1000 HVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+++ R P + + ++A D G L+ + + V D ND+ PVF + Y+ + E
Sbjct: 408 -IVLDREQVPS--YNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPEN 464
Query: 1058 QYTRRVLGKVDATDADFGQNANLTY-----FIQPSDTDLPFEISPLTGVLSVNGELDRET 1112
L V A D D +NA +TY IQ + I+ TGVL D E
Sbjct: 465 NPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQ 524
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
+ V+ARDNG D NDN+P+
Sbjct: 525 FRDLQVKVMARDNG-HPPLSSNVSLSLFVLDQNDNAPE 561
Score = 58.4 bits (135), Expect = 2e-07
Identities = 52/175 (29%), Positives = 79/175 (45%), Gaps = 13/175 (7%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVI--SGAGIYQVTIYIEDENDNPPVFEHATYE 793
G++ T +DRE ++ + + N ++ IY V + + D NDN P F + E
Sbjct: 82 GSLVTAGRIDRE--ELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPYFRESELE 139
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----I 849
I EN+ TE++ + A D D G N+L Y L V K+ +
Sbjct: 140 IKISENA--ATEMRFP-LPHAWDPDIGKNSLQSYELSPNTHFSLIVQNGADGSKYPELVL 196
Query: 850 GDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKV 902
+LDRE+K + L L A D G + A + +M+ D NDN P F Q E + V
Sbjct: 197 KRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRASV 251
Score = 56.4 bits (130), Expect = 7e-07
Identities = 94/386 (24%), Positives = 154/386 (39%), Gaps = 37/386 (9%)
Query: 21 LFTYRDLNRTHVSVILAQSIDSLVDSDSPQNVVKFRLGCDFDEGDDLVRIGA-GLNQI-S 78
L +Y TH S+I+ D S P+ V+K L + LV + G + + +
Sbjct: 167 LQSYELSPNTHFSLIVQNGADG---SKYPELVLKRALDREEKAAHHLVLTASDGGDPVRT 223
Query: 79 AYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGL 138
+ V + D NDN P F Y +V E G + + + +
Sbjct: 224 GTARIRVMVLDANDNAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRY 283
Query: 139 TIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALE---------SSHKPVLLLRKVLD 189
K + F D + S + + + G + +E S+ VL+ VLD
Sbjct: 284 VDDKAAQVFKLDCNSGTISTI--GELDHEESGFYQMEVQAMDNAGYSARAKVLIT--VLD 339
Query: 190 YDAGDKEFQLVIMASG--KRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLD 247
+ E L +AS + + L ++ DQD + I GN F L+
Sbjct: 340 VNDNAPEVVLTSLASSVPENSPRGTLIAL-LNVNDQDSEENGQVIC-FIQGN--LPFKLE 395
Query: 248 SVNGSLF-LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF 306
G+ + L ++ LD E Q ++ + V A+ P + + + + + D NDN P F
Sbjct: 396 KSYGNYYSLVTDIVLDRE---QVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVF 452
Query: 307 EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDP--KGA-----FSIDPRSG 359
Y+ I EN P G S++ V A D D EN + TY L + +GA SI+ +G
Sbjct: 453 PQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTG 512
Query: 360 WLTVRNQTVLDREAHSSLRMKVYAKE 385
L + D E L++KV A++
Sbjct: 513 VLYALSS--FDYEQFRDLQVKVMARD 536
Score = 44.0 bits (99), Expect = 0.004
Identities = 42/170 (24%), Positives = 68/170 (40%), Gaps = 12/170 (7%)
Query: 992 FVINERHGHVIVARSLPPES------EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVF 1045
F +N R G ++ A + E + +LN+ L + V V V+D+ND+ P F
Sbjct: 75 FALNPRSGSLVTAGRIDREELCMGAIKCQLNLDILMEDKVKI-YGVEVEVRDINDNAPYF 133
Query: 1046 KKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG----V 1101
+++ + E T A D D G+N+ +Y + P+ + G
Sbjct: 134 RESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSPNTHFSLIVQNGADGSKYPE 193
Query: 1102 LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
L + LDRE + + L + A D G D NDN+P F
Sbjct: 194 LVLKRALDREEKAAHHLVLTASDGG-DPVRTGTARIRVMVLDANDNAPAF 242
Score = 43.6 bits (98), Expect = 0.006
Identities = 46/170 (27%), Positives = 77/170 (45%), Gaps = 20/170 (11%)
Query: 218 IHAIDQDLGVGATLRYEL----ISGNDRKLF-SLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A D D A + Y L I G + S++S G L+ D + +LQ
Sbjct: 474 VTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQ---- 529
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLPN----GFSV 325
++V A +P ++ + + +LD NDN PE + + VE P G+ V
Sbjct: 530 -VKVMARDNGHPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLV 588
Query: 326 LQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREA 373
+V+A D+D G+N +Y+L G FS+ +G + + +LDR+A
Sbjct: 589 TKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTA-RALLDRDA 637
Score = 39.9 bits (89), Expect = 0.069
Identities = 41/143 (28%), Positives = 60/143 (41%), Gaps = 9/143 (6%)
Query: 221 IDQDLGVG----ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
I +DLG+ A +I +LF+L+ +GSL +D + L Q+
Sbjct: 48 ISRDLGLEPRELAERGVRIIPRGRTQLFALNPRSGSLVTAGRIDRE---ELCMGAIKCQL 104
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
L K VE+E+ D+NDN P F I I EN A D D G
Sbjct: 105 NLDILMED-KVKIYGVEVEVRDINDNAPYFRESELEIKISENAATEMRFPLPHAWDPDIG 163
Query: 337 ENGEFTYQLDDPKGAFSIDPRSG 359
+N +Y+L P FS+ ++G
Sbjct: 164 KNSLQSYEL-SPNTHFSLIVQNG 185
Score = 39.9 bits (89), Expect = 0.069
Identities = 44/174 (25%), Positives = 74/174 (42%), Gaps = 31/174 (17%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P + TA + V V D D P F Y + EN+ +L+ +N T+ E
Sbjct: 218 GDPVRTGTARIRVMVLDANDNA-----PAFAQPEYRASVPENLALGTQLLVVNATDPDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA-ERQKYSREL 1344
N ++RY +D + F +D +GT+ + D E Y++ V+A + YS
Sbjct: 273 VNAEVRYSFRYVDDK-AAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDNAGYSAR- 330
Query: 1345 PHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFG 1398
KV++ + DVNDN+P+ + L +++P +P G
Sbjct: 331 -------------------AKVLITVLDVNDNAPEVVLTS--LASSVPENSPRG 363
Score = 39.1 bits (87), Expect = 0.12
Identities = 38/129 (29%), Positives = 59/129 (45%), Gaps = 13/129 (10%)
Query: 439 LMSFVNVEVTLLDANDNNP-VFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPDLGQ 491
L S V++ + +LD NDN P + P S E + +S A+ G ++ KV AVD D GQ
Sbjct: 542 LSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRS-AEPGYLVTKVVAVDRDSGQ 600
Query: 492 NGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERR 549
N + Y L + S + F + +TG V A + + + +L V D P
Sbjct: 601 NAWLSYRLLKASEPGL---FSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSAT 657
Query: 550 YSLAVVTIE 558
+L V +
Sbjct: 658 VTLTVAVAD 666
>AF152321-1|AAD43715.1| 932|Homo sapiens protocadherin gamma A12
protein.
Length = 932
Score = 114 bits (274), Expect = 3e-24
Identities = 122/476 (25%), Positives = 203/476 (42%), Gaps = 33/476 (6%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
N++ E + VEV + D NDN P F S L E + NA A DPD+G
Sbjct: 105 NLDILMEDKVKIYGVEVEVRDINDNAPYFRESEL-EIKISENAATEMRFPLPHAWDPDIG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSE 547
+N + Y+L ++ ++ + + V + + + H L + ASD +P
Sbjct: 164 KNSLQSYELSPNTHFSLIVQNGADGSKYPELVLKRALDREEKAAHHLVLTASDG-GDPV- 221
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QND 605
R A + + V + P F Y V N+ +GT + + D E +
Sbjct: 222 -RTGTARIRVMVLDAND----NAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGVNAE 276
Query: 606 VSYDLLHGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
V Y + ++ F ++ SG I+ + +L Y E A+ +NA S +
Sbjct: 277 VRYSFRYVDDKAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAM-DNAGYSARAKVLI 335
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
V+DVND ++ + + V ENS + + + N NG V I
Sbjct: 336 TVLDVNDNAPEVVL---TSLASSVPENSPRGTLIALLNVNDQDSEENG--QVICFIQGNL 390
Query: 725 DVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
+ + ++ T LDRE+ Y +TV A ++G + +++ + D NDNP
Sbjct: 391 PFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTAT-DRGTPPLSTETHISLNVADTNDNP 449
Query: 785 PVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEM---FD 838
PVF A+Y +I EN+ G + + A D D NA Y+L +G +
Sbjct: 450 PVFPQASYSAYIPENNPRGVSLVS---VTAHDPDCEENAQITYSLAENTIQGASLSSYVS 506
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPE 892
++ +TGV+ + S D E+ ++ ++ARD G LSS L + + D+NDN PE
Sbjct: 507 INSDTGVL-YALSSFDYEQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPE 561
Score = 85.0 bits (201), Expect = 2e-15
Identities = 108/456 (23%), Positives = 195/456 (42%), Gaps = 32/456 (7%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
+ V +LDANDN P F Y S+ N +GT + V A DPD G N V Y + +
Sbjct: 228 IRVMVLDANDNAPAFAQPE-YRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDD 286
Query: 505 LTITSPFKINPNTGTVS-VAESPILE-GRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
FK++ N+GT+S + E E G + + V+A D + + + V+ +
Sbjct: 287 -KAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDNAGYSARAKVLITVLDV----- 340
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAV 622
+ P+ + V N GT + + VND + ++ + ++ + +PF +
Sbjct: 341 ----NDNAPEVVLTSLASSVPENSPRGTLIALLNVND--QDSEENGQVICFIQGNLPFKL 394
Query: 623 EERSG-VITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLLK 678
E+ G ++V D L R P Y+ A LS T+ +++V D ND V +
Sbjct: 395 EKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQ 454
Query: 679 GAHSPIIFHVKENSAGAAIGQI-FHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED-G 736
++S I + N G ++ + H T ++ ++ ++I D G
Sbjct: 455 ASYSAYI--PENNPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTG 512
Query: 737 TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP--VFEHATYEG 794
++ D E+ ++ V+A N + + +++++ D+NDN P ++ +G
Sbjct: 513 VLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNV-SLSLFVLDQNDNAPEILYPALPTDG 571
Query: 795 FI-MENSKIGTEI-KMDNIIKATDADEGTNALFMYTLFGEGKE-MFDVDENTGVVKFIGD 851
+E + E + + A D D G NA Y L + +F V +TG V+
Sbjct: 572 STGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARA 631
Query: 852 SLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
LDR+ + L + +D G LS+ L + + D
Sbjct: 632 LLDRD-ALKQSLVVAVQDHGQPPLSATVTLTVAVAD 666
Score = 84.6 bits (200), Expect = 2e-15
Identities = 65/195 (33%), Positives = 95/195 (48%), Gaps = 9/195 (4%)
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLF 254
+E +L I S + E+ FP P HA D D+G + YEL L + +GS +
Sbjct: 134 RESELEIKIS-ENAATEMRFPLP-HAWDPDIGKNSLQSYELSPNTHFSLIVQNGADGSKY 191
Query: 255 LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNIS 314
E L + +A L + AS +P++T AR+ + +LD NDN P F Y S
Sbjct: 192 PELVLKRALDREEKA-AHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRAS 250
Query: 315 IVENLPNGFSVLQVMATDKDQGENGE--FTYQLDDPKGA--FSIDPRSGWLTVRNQTVLD 370
+ ENL G +L V ATD D+G N E ++++ D K A F +D SG T+ LD
Sbjct: 251 VPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSG--TISTIGELD 308
Query: 371 REAHSSLRMKVYAKE 385
E +M+V A +
Sbjct: 309 HEESGFYQMEVQAMD 323
Score = 73.3 bits (172), Expect = 6e-12
Identities = 77/290 (26%), Positives = 117/290 (40%), Gaps = 48/290 (16%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN+ +GT ++ +NA D D G+N ++RY F Y+ + + F ++ G
Sbjct: 251 VPENLALGTQLLVVNATDPDEGVNAEVRYSFR---YVDD--------KAAQVFKLDCNSG 299
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ L E +++ + A+D + V + V DVND+ P T +V E
Sbjct: 300 TISTIGELDHEESGFYQMEVQAMDNAGYSARAKVLITVLDVNDNAPEVVLTSLASSVPEN 359
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
++ ++ D D +N + FIQ +LPF++ G L + LDRE
Sbjct: 360 SPRGTLIALLNVNDQDSEENGQVICFIQ---GNLPFKLEKSYGNYYSLVTDIVLDREQVP 416
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFE 1174
Y +TV A D G D NDN P F P+A
Sbjct: 417 SYNITVTATDRG-TPPLSTETHISLNVADTNDNPPVF-----------PQAS-------- 456
Query: 1175 SVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQ 1224
Y A I EN P G ++ V A+D D N I YSL + Q
Sbjct: 457 -------YSAYIPENNPRGVSLVSVTAHDPDC--EENAQITYSLAENTIQ 497
Score = 70.5 bits (165), Expect = 4e-11
Identities = 91/355 (25%), Positives = 142/355 (40%), Gaps = 26/355 (7%)
Query: 997 RHGHVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
++ +++ R+L E + L ++A DGG+ +RV V D ND+ P F + Y
Sbjct: 190 KYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRA 249
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP--FEISPLTGVLSVNGELDR 1110
+V E L V+ATD D G NA + Y + D F++ +G +S GELD
Sbjct: 250 SVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGTISTIGELDH 309
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK--FYAFDELLEWKHPEAD-- 1166
E Y + V A DN DVNDN+P+ + + P
Sbjct: 310 EESGFYQMEVQAMDN---AGYSARAKVLITVLDVNDNAPEVVLTSLASSVPENSPRGTLI 366
Query: 1167 ELSNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQ 1224
L N N + I+ N P + + ++ TD + + + Y++
Sbjct: 367 ALLNVNDQDSEENGQVICFIQGNLPFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATD 426
Query: 1225 QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL--T 1282
+ G P LS+ + + VAD D + PVF Y I EN V LVS+
Sbjct: 427 R--GTPPLSTETHISLNVADTND-----NPPVFPQASYSAYIPENNPRGVSLVSVTAHDP 479
Query: 1283 EHYENFKMRYYILNE--NDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
+ EN ++ Y + + I+ G LY + S D E +V V A
Sbjct: 480 DCEENAQITYSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMA 534
Score = 69.3 bits (162), Expect = 1e-10
Identities = 107/396 (27%), Positives = 169/396 (42%), Gaps = 49/396 (12%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
GTI T LD E+ Y+M V A N G + A +V I + D NDN P +
Sbjct: 299 GTISTIGELDHEESGFYQMEVQAMDNAGYSARA---KVLITVLDVNDNAPEVVLTSLASS 355
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTG-VVKFIGDS-L 853
+ ENS GT I + N+ D D N + F +G F ++++ G + D L
Sbjct: 356 VPENSPRGTLIALLNV---NDQDSEENGQVI--CFIQGNLPFKLEKSYGNYYSLVTDIVL 410
Query: 854 DREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
DRE+ Y +++ A D G LS+E + + + D NDN P F Q ++ + N
Sbjct: 411 DREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYI------PEN 464
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
G +++ V + + Q+ + + EN G ++ +++ D+G + Y +
Sbjct: 465 NPRGVSLVSVTAHDPDCEENAQI--TYSLAENTIQGASLSSYVSINSDTG----VLYALS 518
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISV 1031
S Y + D L+VK V+ +GH P S L++ LD NDN
Sbjct: 519 SFDY----EQFRD-LQVK---VMARDNGHP------PLSSNVSLSLFVLD---QNDNAPE 561
Query: 1032 RVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDL 1091
++ P T A+ ++ KV A D D GQNA L+Y + +
Sbjct: 562 ILY-----PALPTDGSTGVELAPRSAE-PGYLVTKVVAVDRDSGQNAWLSYRLLKASEPG 615
Query: 1092 PFEISPLTG-VLSVNGELDRETEDKYILTVVARDNG 1126
F + TG V + LDR+ K L V +D+G
Sbjct: 616 LFSVGLHTGEVRTARALLDRDAL-KQSLVVAVQDHG 650
Score = 66.5 bits (155), Expect = 7e-10
Identities = 52/179 (29%), Positives = 90/179 (50%), Gaps = 11/179 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR--KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
++A D D GV A +RY +D+ ++F LD +G++ ELD + ++ + ++
Sbjct: 264 VNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGTISTIGELDHE-----ESGFYQME 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
VQA ++N +A+A+V I +LD+NDN PE + S+ EN P G + + D+D
Sbjct: 319 VQA--MDNAGYSARAKVLITVLDVNDNAPEVVLTSLASSVPENSPRGTLIALLNVNDQDS 376
Query: 336 GENGEFTYQLDDPKGAFSIDPRSG-WLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
ENG+ + F ++ G + ++ VLDRE S + V A + + T
Sbjct: 377 EENGQVICFIQG-NLPFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLST 434
Score = 62.9 bits (146), Expect = 9e-09
Identities = 63/218 (28%), Positives = 91/218 (41%), Gaps = 19/218 (8%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN P GT I LN D DS NGQ+ + P KL Y ++ +
Sbjct: 356 VPENSPRGTLIALLNVNDQDSEENGQVICFIQGNL---PFKLEKSYGNY--YSLVTD--- 407
Query: 1000 HVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+++ R P + + ++A D G L+ + + V D ND+ PVF + Y+ + E
Sbjct: 408 -IVLDREQVPS--YNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPEN 464
Query: 1058 QYTRRVLGKVDATDADFGQNANLTY-----FIQPSDTDLPFEISPLTGVLSVNGELDRET 1112
L V A D D +NA +TY IQ + I+ TGVL D E
Sbjct: 465 NPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQ 524
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
+ V+ARDNG D NDN+P+
Sbjct: 525 FRDLQVKVMARDNG-HPPLSSNVSLSLFVLDQNDNAPE 561
Score = 58.4 bits (135), Expect = 2e-07
Identities = 52/175 (29%), Positives = 79/175 (45%), Gaps = 13/175 (7%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVI--SGAGIYQVTIYIEDENDNPPVFEHATYE 793
G++ T +DRE ++ + + N ++ IY V + + D NDN P F + E
Sbjct: 82 GSLVTAGRIDRE--ELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPYFRESELE 139
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----I 849
I EN+ TE++ + A D D G N+L Y L V K+ +
Sbjct: 140 IKISENA--ATEMRFP-LPHAWDPDIGKNSLQSYELSPNTHFSLIVQNGADGSKYPELVL 196
Query: 850 GDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKV 902
+LDRE+K + L L A D G + A + +M+ D NDN P F Q E + V
Sbjct: 197 KRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRASV 251
Score = 56.4 bits (130), Expect = 7e-07
Identities = 94/386 (24%), Positives = 154/386 (39%), Gaps = 37/386 (9%)
Query: 21 LFTYRDLNRTHVSVILAQSIDSLVDSDSPQNVVKFRLGCDFDEGDDLVRIGA-GLNQI-S 78
L +Y TH S+I+ D S P+ V+K L + LV + G + + +
Sbjct: 167 LQSYELSPNTHFSLIVQNGADG---SKYPELVLKRALDREEKAAHHLVLTASDGGDPVRT 223
Query: 79 AYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGL 138
+ V + D NDN P F Y +V E G + + + +
Sbjct: 224 GTARIRVMVLDANDNAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRY 283
Query: 139 TIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALE---------SSHKPVLLLRKVLD 189
K + F D + S + + + G + +E S+ VL+ VLD
Sbjct: 284 VDDKAAQVFKLDCNSGTISTI--GELDHEESGFYQMEVQAMDNAGYSARAKVLIT--VLD 339
Query: 190 YDAGDKEFQLVIMASG--KRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLD 247
+ E L +AS + + L ++ DQD + I GN F L+
Sbjct: 340 VNDNAPEVVLTSLASSVPENSPRGTLIAL-LNVNDQDSEENGQVIC-FIQGN--LPFKLE 395
Query: 248 SVNGSLF-LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF 306
G+ + L ++ LD E Q ++ + V A+ P + + + + + D NDN P F
Sbjct: 396 KSYGNYYSLVTDIVLDRE---QVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVF 452
Query: 307 EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDP--KGA-----FSIDPRSG 359
Y+ I EN P G S++ V A D D EN + TY L + +GA SI+ +G
Sbjct: 453 PQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTG 512
Query: 360 WLTVRNQTVLDREAHSSLRMKVYAKE 385
L + D E L++KV A++
Sbjct: 513 VLYALSS--FDYEQFRDLQVKVMARD 536
Score = 44.0 bits (99), Expect = 0.004
Identities = 42/170 (24%), Positives = 68/170 (40%), Gaps = 12/170 (7%)
Query: 992 FVINERHGHVIVARSLPPES------EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVF 1045
F +N R G ++ A + E + +LN+ L + V V V+D+ND+ P F
Sbjct: 75 FALNPRSGSLVTAGRIDREELCMGAIKCQLNLDILMEDKVKI-YGVEVEVRDINDNAPYF 133
Query: 1046 KKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG----V 1101
+++ + E T A D D G+N+ +Y + P+ + G
Sbjct: 134 RESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSPNTHFSLIVQNGADGSKYPE 193
Query: 1102 LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
L + LDRE + + L + A D G D NDN+P F
Sbjct: 194 LVLKRALDREEKAAHHLVLTASDGG-DPVRTGTARIRVMVLDANDNAPAF 242
Score = 43.6 bits (98), Expect = 0.006
Identities = 46/170 (27%), Positives = 77/170 (45%), Gaps = 20/170 (11%)
Query: 218 IHAIDQDLGVGATLRYEL----ISGNDRKLF-SLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A D D A + Y L I G + S++S G L+ D + +LQ
Sbjct: 474 VTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQ---- 529
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLPN----GFSV 325
++V A +P ++ + + +LD NDN PE + + VE P G+ V
Sbjct: 530 -VKVMARDNGHPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLV 588
Query: 326 LQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREA 373
+V+A D+D G+N +Y+L G FS+ +G + + +LDR+A
Sbjct: 589 TKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTA-RALLDRDA 637
Score = 39.9 bits (89), Expect = 0.069
Identities = 41/143 (28%), Positives = 60/143 (41%), Gaps = 9/143 (6%)
Query: 221 IDQDLGVG----ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
I +DLG+ A +I +LF+L+ +GSL +D + L Q+
Sbjct: 48 ISRDLGLEPRELAERGVRIIPRGRTQLFALNPRSGSLVTAGRIDRE---ELCMGAIKCQL 104
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
L K VE+E+ D+NDN P F I I EN A D D G
Sbjct: 105 NLDILMED-KVKIYGVEVEVRDINDNAPYFRESELEIKISENAATEMRFPLPHAWDPDIG 163
Query: 337 ENGEFTYQLDDPKGAFSIDPRSG 359
+N +Y+L P FS+ ++G
Sbjct: 164 KNSLQSYEL-SPNTHFSLIVQNG 185
Score = 39.9 bits (89), Expect = 0.069
Identities = 44/174 (25%), Positives = 74/174 (42%), Gaps = 31/174 (17%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P + TA + V V D D P F Y + EN+ +L+ +N T+ E
Sbjct: 218 GDPVRTGTARIRVMVLDANDNA-----PAFAQPEYRASVPENLALGTQLLVVNATDPDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA-ERQKYSREL 1344
N ++RY +D + F +D +GT+ + D E Y++ V+A + YS
Sbjct: 273 VNAEVRYSFRYVDDK-AAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDNAGYSAR- 330
Query: 1345 PHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFG 1398
KV++ + DVNDN+P+ + L +++P +P G
Sbjct: 331 -------------------AKVLITVLDVNDNAPEVVLTS--LASSVPENSPRG 363
Score = 39.1 bits (87), Expect = 0.12
Identities = 38/129 (29%), Positives = 59/129 (45%), Gaps = 13/129 (10%)
Query: 439 LMSFVNVEVTLLDANDNNP-VFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPDLGQ 491
L S V++ + +LD NDN P + P S E + +S A+ G ++ KV AVD D GQ
Sbjct: 542 LSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRS-AEPGYLVTKVVAVDRDSGQ 600
Query: 492 NGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERR 549
N + Y L + S + F + +TG V A + + + +L V D P
Sbjct: 601 NAWLSYRLLKASEPGL---FSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSAT 657
Query: 550 YSLAVVTIE 558
+L V +
Sbjct: 658 VTLTVAVAD 666
>AB011160-1|BAA25514.2| 938|Homo sapiens KIAA0588 protein protein.
Length = 938
Score = 114 bits (274), Expect = 3e-24
Identities = 122/476 (25%), Positives = 203/476 (42%), Gaps = 33/476 (6%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
N++ E + VEV + D NDN P F S L E + NA A DPD+G
Sbjct: 111 NLDILMEDKVKIYGVEVEVRDINDNAPYFRESEL-EIKISENAATEMRFPLPHAWDPDIG 169
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSE 547
+N + Y+L ++ ++ + + V + + + H L + ASD +P
Sbjct: 170 KNSLQSYELSPNTHFSLIVQNGADGSKYPELVLKRALDREEKAAHHLVLTASDG-GDPV- 227
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QND 605
R A + + V + P F Y V N+ +GT + + D E +
Sbjct: 228 -RTGTARIRVMVLDAND----NAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGVNAE 282
Query: 606 VSYDLLHGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
V Y + ++ F ++ SG I+ + +L Y E A+ +NA S +
Sbjct: 283 VRYSFRYVDDKAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAM-DNAGYSARAKVLI 341
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
V+DVND ++ + + V ENS + + + N NG V I
Sbjct: 342 TVLDVNDNAPEVVL---TSLASSVPENSPRGTLIALLNVNDQDSEENG--QVICFIQGNL 396
Query: 725 DVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
+ + ++ T LDRE+ Y +TV A ++G + +++ + D NDNP
Sbjct: 397 PFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTAT-DRGTPPLSTETHISLNVADTNDNP 455
Query: 785 PVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEM---FD 838
PVF A+Y +I EN+ G + + A D D NA Y+L +G +
Sbjct: 456 PVFPQASYSAYIPENNPRGVSLVS---VTAHDPDCEENAQITYSLAENTIQGASLSSYVS 512
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPE 892
++ +TGV+ + S D E+ ++ ++ARD G LSS L + + D+NDN PE
Sbjct: 513 INSDTGVL-YALSSFDYEQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPE 567
Score = 85.0 bits (201), Expect = 2e-15
Identities = 108/456 (23%), Positives = 195/456 (42%), Gaps = 32/456 (7%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
+ V +LDANDN P F Y S+ N +GT + V A DPD G N V Y + +
Sbjct: 234 IRVMVLDANDNAPAFAQPE-YRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDD 292
Query: 505 LTITSPFKINPNTGTVS-VAESPILE-GRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
FK++ N+GT+S + E E G + + V+A D + + + V+ +
Sbjct: 293 -KAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDNAGYSARAKVLITVLDV----- 346
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAV 622
+ P+ + V N GT + + VND + ++ + ++ + +PF +
Sbjct: 347 ----NDNAPEVVLTSLASSVPENSPRGTLIALLNVND--QDSEENGQVICFIQGNLPFKL 400
Query: 623 EERSG-VITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLLK 678
E+ G ++V D L R P Y+ A LS T+ +++V D ND V +
Sbjct: 401 EKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQ 460
Query: 679 GAHSPIIFHVKENSAGAAIGQI-FHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED-G 736
++S I + N G ++ + H T ++ ++ ++I D G
Sbjct: 461 ASYSAYI--PENNPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTG 518
Query: 737 TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP--VFEHATYEG 794
++ D E+ ++ V+A N + + +++++ D+NDN P ++ +G
Sbjct: 519 VLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNV-SLSLFVLDQNDNAPEILYPALPTDG 577
Query: 795 FI-MENSKIGTEI-KMDNIIKATDADEGTNALFMYTLFGEGKE-MFDVDENTGVVKFIGD 851
+E + E + + A D D G NA Y L + +F V +TG V+
Sbjct: 578 STGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARA 637
Query: 852 SLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
LDR+ + L + +D G LS+ L + + D
Sbjct: 638 LLDRD-ALKQSLVVAVQDHGQPPLSATVTLTVAVAD 672
Score = 84.6 bits (200), Expect = 2e-15
Identities = 65/195 (33%), Positives = 95/195 (48%), Gaps = 9/195 (4%)
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLF 254
+E +L I S + E+ FP P HA D D+G + YEL L + +GS +
Sbjct: 140 RESELEIKIS-ENAATEMRFPLP-HAWDPDIGKNSLQSYELSPNTHFSLIVQNGADGSKY 197
Query: 255 LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNIS 314
E L + +A L + AS +P++T AR+ + +LD NDN P F Y S
Sbjct: 198 PELVLKRALDREEKA-AHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRAS 256
Query: 315 IVENLPNGFSVLQVMATDKDQGENGE--FTYQLDDPKGA--FSIDPRSGWLTVRNQTVLD 370
+ ENL G +L V ATD D+G N E ++++ D K A F +D SG T+ LD
Sbjct: 257 VPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSG--TISTIGELD 314
Query: 371 REAHSSLRMKVYAKE 385
E +M+V A +
Sbjct: 315 HEESGFYQMEVQAMD 329
Score = 73.3 bits (172), Expect = 6e-12
Identities = 77/290 (26%), Positives = 117/290 (40%), Gaps = 48/290 (16%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN+ +GT ++ +NA D D G+N ++RY F Y+ + + F ++ G
Sbjct: 257 VPENLALGTQLLVVNATDPDEGVNAEVRYSFR---YVDD--------KAAQVFKLDCNSG 305
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ L E +++ + A+D + V + V DVND+ P T +V E
Sbjct: 306 TISTIGELDHEESGFYQMEVQAMDNAGYSARAKVLITVLDVNDNAPEVVLTSLASSVPEN 365
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
++ ++ D D +N + FIQ +LPF++ G L + LDRE
Sbjct: 366 SPRGTLIALLNVNDQDSEENGQVICFIQ---GNLPFKLEKSYGNYYSLVTDIVLDREQVP 422
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFE 1174
Y +TV A D G D NDN P F P+A
Sbjct: 423 SYNITVTATDRG-TPPLSTETHISLNVADTNDNPPVF-----------PQAS-------- 462
Query: 1175 SVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQ 1224
Y A I EN P G ++ V A+D D N I YSL + Q
Sbjct: 463 -------YSAYIPENNPRGVSLVSVTAHDPDC--EENAQITYSLAENTIQ 503
Score = 70.5 bits (165), Expect = 4e-11
Identities = 91/355 (25%), Positives = 142/355 (40%), Gaps = 26/355 (7%)
Query: 997 RHGHVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
++ +++ R+L E + L ++A DGG+ +RV V D ND+ P F + Y
Sbjct: 196 KYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRA 255
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP--FEISPLTGVLSVNGELDR 1110
+V E L V+ATD D G NA + Y + D F++ +G +S GELD
Sbjct: 256 SVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGTISTIGELDH 315
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK--FYAFDELLEWKHPEAD-- 1166
E Y + V A DN DVNDN+P+ + + P
Sbjct: 316 EESGFYQMEVQAMDN---AGYSARAKVLITVLDVNDNAPEVVLTSLASSVPENSPRGTLI 372
Query: 1167 ELSNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQ 1224
L N N + I+ N P + + ++ TD + + + Y++
Sbjct: 373 ALLNVNDQDSEENGQVICFIQGNLPFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATD 432
Query: 1225 QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL--T 1282
+ G P LS+ + + VAD D + PVF Y I EN V LVS+
Sbjct: 433 R--GTPPLSTETHISLNVADTND-----NPPVFPQASYSAYIPENNPRGVSLVSVTAHDP 485
Query: 1283 EHYENFKMRYYILNE--NDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
+ EN ++ Y + + I+ G LY + S D E +V V A
Sbjct: 486 DCEENAQITYSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMA 540
Score = 69.3 bits (162), Expect = 1e-10
Identities = 107/396 (27%), Positives = 169/396 (42%), Gaps = 49/396 (12%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
GTI T LD E+ Y+M V A N G + A +V I + D NDN P +
Sbjct: 305 GTISTIGELDHEESGFYQMEVQAMDNAGYSARA---KVLITVLDVNDNAPEVVLTSLASS 361
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTG-VVKFIGDS-L 853
+ ENS GT I + N+ D D N + F +G F ++++ G + D L
Sbjct: 362 VPENSPRGTLIALLNV---NDQDSEENGQVI--CFIQGNLPFKLEKSYGNYYSLVTDIVL 416
Query: 854 DREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
DRE+ Y +++ A D G LS+E + + + D NDN P F Q ++ + N
Sbjct: 417 DREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYI------PEN 470
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
G +++ V + + Q+ + + EN G ++ +++ D+G + Y +
Sbjct: 471 NPRGVSLVSVTAHDPDCEENAQI--TYSLAENTIQGASLSSYVSINSDTG----VLYALS 524
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISV 1031
S Y + D L+VK V+ +GH P S L++ LD NDN
Sbjct: 525 SFDY----EQFRD-LQVK---VMARDNGHP------PLSSNVSLSLFVLD---QNDNAPE 567
Query: 1032 RVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDL 1091
++ P T A+ ++ KV A D D GQNA L+Y + +
Sbjct: 568 ILY-----PALPTDGSTGVELAPRSAE-PGYLVTKVVAVDRDSGQNAWLSYRLLKASEPG 621
Query: 1092 PFEISPLTG-VLSVNGELDRETEDKYILTVVARDNG 1126
F + TG V + LDR+ K L V +D+G
Sbjct: 622 LFSVGLHTGEVRTARALLDRDAL-KQSLVVAVQDHG 656
Score = 66.5 bits (155), Expect = 7e-10
Identities = 52/179 (29%), Positives = 90/179 (50%), Gaps = 11/179 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR--KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
++A D D GV A +RY +D+ ++F LD +G++ ELD + ++ + ++
Sbjct: 270 VNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGTISTIGELDHE-----ESGFYQME 324
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
VQA ++N +A+A+V I +LD+NDN PE + S+ EN P G + + D+D
Sbjct: 325 VQA--MDNAGYSARAKVLITVLDVNDNAPEVVLTSLASSVPENSPRGTLIALLNVNDQDS 382
Query: 336 GENGEFTYQLDDPKGAFSIDPRSG-WLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
ENG+ + F ++ G + ++ VLDRE S + V A + + T
Sbjct: 383 EENGQVICFIQG-NLPFKLEKSYGNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLST 440
Score = 62.9 bits (146), Expect = 9e-09
Identities = 63/218 (28%), Positives = 91/218 (41%), Gaps = 19/218 (8%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN P GT I LN D DS NGQ+ + P KL Y ++ +
Sbjct: 362 VPENSPRGTLIALLNVNDQDSEENGQVICFIQGNL---PFKLEKSYGNY--YSLVTD--- 413
Query: 1000 HVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+++ R P + + ++A D G L+ + + V D ND+ PVF + Y+ + E
Sbjct: 414 -IVLDREQVPS--YNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPEN 470
Query: 1058 QYTRRVLGKVDATDADFGQNANLTY-----FIQPSDTDLPFEISPLTGVLSVNGELDRET 1112
L V A D D +NA +TY IQ + I+ TGVL D E
Sbjct: 471 NPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQ 530
Query: 1113 EDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
+ V+ARDNG D NDN+P+
Sbjct: 531 FRDLQVKVMARDNG-HPPLSSNVSLSLFVLDQNDNAPE 567
Score = 58.4 bits (135), Expect = 2e-07
Identities = 52/175 (29%), Positives = 79/175 (45%), Gaps = 13/175 (7%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVI--SGAGIYQVTIYIEDENDNPPVFEHATYE 793
G++ T +DRE ++ + + N ++ IY V + + D NDN P F + E
Sbjct: 88 GSLVTAGRIDRE--ELCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDNAPYFRESELE 145
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----I 849
I EN+ TE++ + A D D G N+L Y L V K+ +
Sbjct: 146 IKISENA--ATEMRFP-LPHAWDPDIGKNSLQSYELSPNTHFSLIVQNGADGSKYPELVL 202
Query: 850 GDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKV 902
+LDRE+K + L L A D G + A + +M+ D NDN P F Q E + V
Sbjct: 203 KRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRASV 257
Score = 56.4 bits (130), Expect = 7e-07
Identities = 94/386 (24%), Positives = 154/386 (39%), Gaps = 37/386 (9%)
Query: 21 LFTYRDLNRTHVSVILAQSIDSLVDSDSPQNVVKFRLGCDFDEGDDLVRIGA-GLNQI-S 78
L +Y TH S+I+ D S P+ V+K L + LV + G + + +
Sbjct: 173 LQSYELSPNTHFSLIVQNGADG---SKYPELVLKRALDREEKAAHHLVLTASDGGDPVRT 229
Query: 79 AYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGL 138
+ V + D NDN P F Y +V E G + + + +
Sbjct: 230 GTARIRVMVLDANDNAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRY 289
Query: 139 TIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALE---------SSHKPVLLLRKVLD 189
K + F D + S + + + G + +E S+ VL+ VLD
Sbjct: 290 VDDKAAQVFKLDCNSGTISTI--GELDHEESGFYQMEVQAMDNAGYSARAKVLIT--VLD 345
Query: 190 YDAGDKEFQLVIMASG--KRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLD 247
+ E L +AS + + L ++ DQD + I GN F L+
Sbjct: 346 VNDNAPEVVLTSLASSVPENSPRGTLIAL-LNVNDQDSEENGQVIC-FIQGN--LPFKLE 401
Query: 248 SVNGSLF-LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF 306
G+ + L ++ LD E Q ++ + V A+ P + + + + + D NDN P F
Sbjct: 402 KSYGNYYSLVTDIVLDRE---QVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVF 458
Query: 307 EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDP--KGA-----FSIDPRSG 359
Y+ I EN P G S++ V A D D EN + TY L + +GA SI+ +G
Sbjct: 459 PQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTG 518
Query: 360 WLTVRNQTVLDREAHSSLRMKVYAKE 385
L + D E L++KV A++
Sbjct: 519 VLYALSS--FDYEQFRDLQVKVMARD 542
Score = 44.0 bits (99), Expect = 0.004
Identities = 42/170 (24%), Positives = 68/170 (40%), Gaps = 12/170 (7%)
Query: 992 FVINERHGHVIVARSLPPES------EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVF 1045
F +N R G ++ A + E + +LN+ L + V V V+D+ND+ P F
Sbjct: 81 FALNPRSGSLVTAGRIDREELCMGAIKCQLNLDILMEDKVKI-YGVEVEVRDINDNAPYF 139
Query: 1046 KKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG----V 1101
+++ + E T A D D G+N+ +Y + P+ + G
Sbjct: 140 RESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSPNTHFSLIVQNGADGSKYPE 199
Query: 1102 LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
L + LDRE + + L + A D G D NDN+P F
Sbjct: 200 LVLKRALDREEKAAHHLVLTASDGG-DPVRTGTARIRVMVLDANDNAPAF 248
Score = 43.6 bits (98), Expect = 0.006
Identities = 46/170 (27%), Positives = 77/170 (45%), Gaps = 20/170 (11%)
Query: 218 IHAIDQDLGVGATLRYEL----ISGNDRKLF-SLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A D D A + Y L I G + S++S G L+ D + +LQ
Sbjct: 480 VTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQ---- 535
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLPN----GFSV 325
++V A +P ++ + + +LD NDN PE + + VE P G+ V
Sbjct: 536 -VKVMARDNGHPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLV 594
Query: 326 LQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREA 373
+V+A D+D G+N +Y+L G FS+ +G + + +LDR+A
Sbjct: 595 TKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTA-RALLDRDA 643
Score = 39.9 bits (89), Expect = 0.069
Identities = 41/143 (28%), Positives = 60/143 (41%), Gaps = 9/143 (6%)
Query: 221 IDQDLGVG----ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
I +DLG+ A +I +LF+L+ +GSL +D + L Q+
Sbjct: 54 ISRDLGLEPRELAERGVRIIPRGRTQLFALNPRSGSLVTAGRIDRE---ELCMGAIKCQL 110
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
L K VE+E+ D+NDN P F I I EN A D D G
Sbjct: 111 NLDILMED-KVKIYGVEVEVRDINDNAPYFRESELEIKISENAATEMRFPLPHAWDPDIG 169
Query: 337 ENGEFTYQLDDPKGAFSIDPRSG 359
+N +Y+L P FS+ ++G
Sbjct: 170 KNSLQSYEL-SPNTHFSLIVQNG 191
Score = 39.9 bits (89), Expect = 0.069
Identities = 44/174 (25%), Positives = 74/174 (42%), Gaps = 31/174 (17%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P + TA + V V D D P F Y + EN+ +L+ +N T+ E
Sbjct: 224 GDPVRTGTARIRVMVLDANDNA-----PAFAQPEYRASVPENLALGTQLLVVNATDPDEG 278
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA-ERQKYSREL 1344
N ++RY +D + F +D +GT+ + D E Y++ V+A + YS
Sbjct: 279 VNAEVRYSFRYVDDK-AAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDNAGYSAR- 336
Query: 1345 PHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFG 1398
KV++ + DVNDN+P+ + L +++P +P G
Sbjct: 337 -------------------AKVLITVLDVNDNAPEVVLTS--LASSVPENSPRG 369
Score = 39.1 bits (87), Expect = 0.12
Identities = 38/129 (29%), Positives = 59/129 (45%), Gaps = 13/129 (10%)
Query: 439 LMSFVNVEVTLLDANDNNP-VFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPDLGQ 491
L S V++ + +LD NDN P + P S E + +S A+ G ++ KV AVD D GQ
Sbjct: 548 LSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRS-AEPGYLVTKVVAVDRDSGQ 606
Query: 492 NGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERR 549
N + Y L + S + F + +TG V A + + + +L V D P
Sbjct: 607 NAWLSYRLLKASEPGL---FSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSAT 663
Query: 550 YSLAVVTIE 558
+L V +
Sbjct: 664 VTLTVAVAD 672
>BC038797-1|AAH38797.1| 787|Homo sapiens protocadherin beta 15
protein.
Length = 787
Score = 113 bits (273), Expect = 3e-24
Identities = 116/462 (25%), Positives = 199/462 (43%), Gaps = 38/462 (8%)
Query: 446 EVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNL 505
E+ + D ND++P F P + + +GTV KA D D+G N + Y++ S+
Sbjct: 120 ELLVTDINDHSPEF-PEREMTLKIPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNSHF 178
Query: 506 TITSPFKINPNTGTVSVAESPILEGRHA---LFVEASDQPANPSERRYSLAVVTIEVTRG 562
+++ + + V ++ + A L + A D + P + ++ ++
Sbjct: 179 HVSTRTRGDGRKYPELVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDAN-- 236
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLHGYEE-GVP 619
+ P+F+ A YE V N +G+ V ++ D ++SY L + +E P
Sbjct: 237 -----DNAPEFVQALYEVQVPENSPVGSLVVKVSARDLDTGTNGEISYSLYYSSQEIDKP 291
Query: 620 FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKG 679
F + SG I ++ L YD + A + LS + +V V+DVND L
Sbjct: 292 FELSSLSGEIRLIKKLDFETMSSYDLDIEA-SDGGGLSGKCSVSVKVLDVNDNFPEL--- 347
Query: 680 AHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDG--T 737
+ S + + ENS + +F NG + + + Q DV + + +
Sbjct: 348 SISSLTSPIPENSPETEVA-LFRIRDRDSGENG----KMICSIQDDVPFKLKPSVENFYR 402
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
+ T+ LDRE R Y +T+ + G +T+ + D NDN P F +Y F+
Sbjct: 403 LVTEGALDRETRAEYNITITIT-DLGTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLFVR 461
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDENTGVVKFIGD 851
EN+ I ++ATD D GTNA Y+L + ++ + G + F
Sbjct: 462 ENNSPALHI---GSVRATDRDSGTNAQVTYSLLPPQDPHLPLTSLVSINTDNGHL-FALQ 517
Query: 852 SLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 518 SLDYEALQAFEFRVGATDRGFPALSSEALVRVLVLDANDNSP 559
Score = 98.3 bits (234), Expect = 2e-19
Identities = 123/493 (24%), Positives = 199/493 (40%), Gaps = 63/493 (12%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEF--NSEVYIPPSKLSADALEVKRYFVINER 997
IPE +GT A DLD G N Y NS ++ ++ D + + E
Sbjct: 142 IPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNSHFHV-STRTRGDGRKYPELVLDTE- 199
Query: 998 HGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
++E RL ++A+DGG+ + + + + V D ND+ P F + Y V
Sbjct: 200 -------LDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNAPEFVQALYEVQVP 252
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTY--FIQPSDTDLPFEISPLTGVLSVNGELDRETE 1113
E ++ KV A D D G N ++Y + + D PFE+S L+G + + +LD ET
Sbjct: 253 ENSPVGSLVVKVSARDLDTGTNGEISYSLYYSSQEIDKPFELSSLSGEIRLIKKLDFETM 312
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK--FYAFDELLEWKHPEADEL--- 1168
Y L + A D G DVNDN P+ + + PE +
Sbjct: 313 SSYDLDIEASDGG---GLSGKCSVSVKVLDVNDNFPELSISSLTSPIPENSPETEVALFR 369
Query: 1169 --SNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQ 1224
+ E+ MI +I+++ P + +V + T+ + Y++
Sbjct: 370 IRDRDSGENGKMI----CSIQDDVPFKLKPSVENFYRLVTEGALDRETRAEYNI--TITI 423
Query: 1225 QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEH 1284
+LG P L + + V V+DV D + P F Y L + EN + + + S+ T+
Sbjct: 424 TDLGTPRLKTEQSITVLVSDVND-----NAPAFTQTSYTLFVRENNSPALHIGSVRATDR 478
Query: 1285 YE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREVKDTYEVIVRAERQKY 1340
N ++ Y +L D + T + I+ NG L+ ++S D E +E V A
Sbjct: 479 DSGTNAQVTYSLLPPQDPHLPLTSLVSINTDNGHLFALQSLDYEALQAFEFRVGAT---- 534
Query: 1341 SRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTNGNRPLVTAIPTTAP 1396
R P + + V V + D NDNSP NG+ P +P A
Sbjct: 535 DRGFPAL-------------SSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAE 581
Query: 1397 FGYQVMQLKGAIG 1409
GY V ++ G
Sbjct: 582 PGYLVTKVVAVDG 594
Score = 83.8 bits (198), Expect = 4e-15
Identities = 53/154 (34%), Positives = 81/154 (52%), Gaps = 8/154 (5%)
Query: 744 LDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIG 803
LDRE++ R+T+ A + G +G Q+ I + D NDN P F A YE + ENS +G
Sbjct: 200 LDREEQAELRLTLTA-VDGGSPPRSGTVQILILVLDANDNAPEFVQALYEVQVPENSPVG 258
Query: 804 TEIKMDNIIKATDADEGTNALFMYTLFGEGKEM---FDVDENTGVVKFIGDSLDREKKIM 860
+ + + A D D GTN Y+L+ +E+ F++ +G ++ I LD E
Sbjct: 259 SLVVK---VSARDLDTGTNGEISYSLYYSSQEIDKPFELSSLSGEIRLI-KKLDFETMSS 314
Query: 861 YKLSLVARDTGGLSSEAELIIMIGDENDNKPEFN 894
Y L + A D GGLS + + + + D NDN PE +
Sbjct: 315 YDLDIEASDGGGLSGKCSVSVKVLDVNDNFPELS 348
Score = 80.2 bits (189), Expect = 5e-14
Identities = 109/460 (23%), Positives = 193/460 (41%), Gaps = 38/460 (8%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V + + +LDANDN P FV + LYE + N+ VG+++ KV A D D G NG + Y L +
Sbjct: 226 VQILILVLDANDNAPEFVQA-LYEVQVPENSPVGSLVVKVSARDLDTGTNGEISYSLYYS 284
Query: 503 SNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIEVT 560
S I PF+++ +G + + + E + L +EASD + S++V ++V
Sbjct: 285 SQ-EIDKPFELSSLSGEIRLIKKLDFETMSSYDLDIEASD--GGGLSGKCSVSVKVLDV- 340
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P+ + + N T V R+ D + + ++ ++ VPF
Sbjct: 341 ------NDNFPELSISSLTSPIPEN-SPETEVALFRIRD--RDSGENGKMICSIQDDVPF 391
Query: 621 AVE---ERSGVITVVDDLSRYNRPMYDFE-AVALQENANLSIVTNATVHVVDVNDERGVL 676
++ E + L R R Y+ + L + TV V DVND
Sbjct: 392 KLKPSVENFYRLVTEGALDRETRAEYNITITITDLGTPRLKTEQSITVLVSDVNDNAPAF 451
Query: 677 LKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD----VTDDIAI 732
+ +++ +F + NS IG + T+ S V + + QD +T ++I
Sbjct: 452 TQTSYT--LFVRENNSPALHIGSVRATDRDS---GTNAQVTYSLLPPQDPHLPLTSLVSI 506
Query: 733 -AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
++G +F + LD E + V A ++G + + V + + D NDN P +
Sbjct: 507 NTDNGHLFALQSLDYEALQAFEFRVGAT-DRGFPALSSEALVRVLVLDANDNSPFVLYPL 565
Query: 792 YEGFIMENSKIGTEIKMDNIIK---ATDADEGTNALFMYTLFGEGKE-MFDVDENTGVVK 847
G + + ++ A D D G NA Y L + +F V + G V+
Sbjct: 566 QNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVR 625
Query: 848 FIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
L ++L ++ +D G S+ A L +++ D
Sbjct: 626 -TARLLSERDVAKHRLVVLVKDNGEPPRSATATLQVLLVD 664
Score = 63.3 bits (147), Expect = 6e-09
Identities = 49/170 (28%), Positives = 76/170 (44%), Gaps = 7/170 (4%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D+G Y + + + + +G + E LD + + QA L + A
Sbjct: 157 ARDLDVGSNNVQNYNISPNSHFHVSTRTRGDGRKYPELVLDTELDREEQAE-LRLTLTAV 215
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
+P ++ ++ I +LD NDN PEF Y + + EN P G V++V A D D G NG
Sbjct: 216 DGGSPPRSGTVQILILVLDANDNAPEFVQALYEVQVPENSPVGSLVVKVSARDLDTGTNG 275
Query: 340 EFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
E +Y L + F + SG +R LD E SS + + A +
Sbjct: 276 EISYSLYYSSQEIDKPFELSSLSG--EIRLIKKLDFETMSSYDLDIEASD 323
Score = 60.1 bits (139), Expect = 6e-08
Identities = 56/181 (30%), Positives = 84/181 (46%), Gaps = 20/181 (11%)
Query: 218 IHAIDQDLGVGATLRYELISGND-----RKLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A D+D G A + Y L+ D L S+++ NG LF + LD +A LQA F
Sbjct: 473 VRATDRDSGTNAQVTYSLLPPQDPHLPLTSLVSINTDNGHLFALQSLDYEA---LQA--F 527
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISI--VENLPN----GFSVL 326
+V A+ P +++A V + +LD NDN P N S E +P G+ V
Sbjct: 528 EFRVGATDRGFPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVT 587
Query: 327 QVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAK 384
+V+A D D G+N +YQL G F + +G VR +L + R+ V K
Sbjct: 588 KVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG--EVRTARLLSERDVAKHRLVVLVK 645
Query: 385 E 385
+
Sbjct: 646 D 646
Score = 58.8 bits (136), Expect = 1e-07
Identities = 44/167 (26%), Positives = 74/167 (44%), Gaps = 12/167 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR--KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A D D G + Y L + K F L S++G + L K+LD + +++ L
Sbjct: 264 VSARDLDTGTNGEISYSLYYSSQEIDKPFELSSLSGEIRLIKKLDFET-----MSSYDLD 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
++AS + + V +++LD+NDN PE + I EN P V D+D
Sbjct: 319 IEASDGGG--LSGKCSVSVKVLDVNDNFPELSISSLTSPIPENSPE-TEVALFRIRDRDS 375
Query: 336 GENGEFTYQLDDPKGAFSIDPR-SGWLTVRNQTVLDREAHSSLRMKV 381
GENG+ + D F + P + + + LDRE + + +
Sbjct: 376 GENGKMICSIQDDV-PFKLKPSVENFYRLVTEGALDRETRAEYNITI 421
Score = 55.2 bits (127), Expect = 2e-06
Identities = 58/200 (29%), Positives = 82/200 (41%), Gaps = 19/200 (9%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
LF+ N P I + A D DSG N Q+ Y +PP L + IN
Sbjct: 458 LFVRENNSP-ALHIGSVRATDRDSGTNAQVTYSL-----LPPQD---PHLPLTSLVSINT 508
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+GH+ +SL E+ F + A D G L+ VRV V D ND+ P N
Sbjct: 509 DNGHLFALQSLDYEALQAFEFRVGATDRGFPALSSEALVRVLVLDANDNSPFVLYPLQNG 568
Query: 1053 NVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
+ + R ++ KV A D D GQNA L+Y + + F + G +
Sbjct: 569 SAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTAR 628
Query: 1107 ELDRETEDKYILTVVARDNG 1126
L K+ L V+ +DNG
Sbjct: 629 LLSERDVAKHRLVVLVKDNG 648
Score = 54.4 bits (125), Expect = 3e-06
Identities = 48/180 (26%), Positives = 77/180 (42%), Gaps = 12/180 (6%)
Query: 722 NQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
N+Q + D+ + G + + LDREK I F + +++ + + D N
Sbjct: 71 NEQGLQLDL---QTGQLILNEKLDREKLCGPTEPCIMHFQVLLKKPLEVFRAELLVTDIN 127
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDE 841
D+ P F I E S +GT + KA D D G+N + Y +
Sbjct: 128 DHSPEFPEREMTLKIPETSSLGTVFPLK---KARDLDVGSNNVQNYNISPNSHFHVSTRT 184
Query: 842 NTGVVKF----IGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
K+ + LDRE++ +L+L A D G S +++I++ D NDN PEF Q
Sbjct: 185 RGDGRKYPELVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNAPEFVQ 244
Score = 51.6 bits (118), Expect = 2e-05
Identities = 84/368 (22%), Positives = 142/368 (38%), Gaps = 55/368 (14%)
Query: 1033 VFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP 1092
+ V D+NDH P F + + E V A D D G N Y I P+
Sbjct: 121 LLVTDINDHSPEFPEREMTLKIPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNS---H 177
Query: 1093 FEISPLT-------GVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
F +S T L ++ ELDRE + + LT+ A D G D N
Sbjct: 178 FHVSTRTRGDGRKYPELVLDTELDREEQAELRLTLTAVDGG-SPPRSGTVQILILVLDAN 236
Query: 1146 DNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTD 1205
DN+P+F L E + P EN+P+G+ V KV A D D
Sbjct: 237 DNAPEF--VQALYEVQVP------------------------ENSPVGSLVVKVSARDLD 270
Query: 1206 FIGNGNGLILYSL--PQRKNQQNLGLPSLSSTAILM-----VTVADVPDEVEMSDKPVFI 1258
NG I YSL ++ + L SLS L+ T++ ++E SD
Sbjct: 271 --TGTNGEISYSLYYSSQEIDKPFELSSLSGEIRLIKKLDFETMSSYDLDIEASDGGGLS 328
Query: 1259 SR----YYELEIEENV-NAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNG 1313
+ L++ +N + ++ + E+ ++ + + + D+ + ++
Sbjct: 329 GKCSVSVKVLDVNDNFPELSISSLTSPIPENSPETEVALFRIRDRDSGENGKMICSIQDD 388
Query: 1314 TLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDV 1373
+ ++ V++ Y ++ + +R + I D+ K + + V + DV
Sbjct: 389 VPFKLKP---SVENFYRLVTEGALDRETR-AEYNITITITDLGTPRLKTEQSITVLVSDV 444
Query: 1374 NDNSPKFT 1381
NDN+P FT
Sbjct: 445 NDNAPAFT 452
Score = 51.2 bits (117), Expect = 3e-05
Identities = 57/250 (22%), Positives = 100/250 (40%), Gaps = 16/250 (6%)
Query: 666 VVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRF-LIANQQ 724
V+D ND ++ + V ENS ++ + + + G + + L + Q
Sbjct: 232 VLDANDNAPEFVQALYE---VQVPENSPVGSL--VVKVSARDLDTGTNGEISYSLYYSSQ 286
Query: 725 DVTDDIAIAE-DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDN 783
++ ++ G I K LD E Y + + A G+ +G V++ + D NDN
Sbjct: 287 EIDKPFELSSLSGEIRLIKKLDFETMSSYDLDIEASDGGGL---SGKCSVSVKVLDVNDN 343
Query: 784 PPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENT 843
P ++ I ENS TE+ + I D D G N + ++ +
Sbjct: 344 FPELSISSLTSPIPENSP-ETEVALFRI---RDRDSGENGKMICSIQDDVPFKLKPSVEN 399
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSK 901
+LDRE + Y +++ D G L +E + +++ D NDN P F Q
Sbjct: 400 FYRLVTEGALDRETRAEYNITITITDLGTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLF 459
Query: 902 VRIHRETKLN 911
VR + L+
Sbjct: 460 VRENNSPALH 469
Score = 49.6 bits (113), Expect = 8e-05
Identities = 34/103 (33%), Positives = 49/103 (47%), Gaps = 5/103 (4%)
Query: 248 SVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNP-LKTAQARVEIELLDLNDNLPEF 306
SV L E LD E + N + + + L P LKT Q+ + + + D+NDN P F
Sbjct: 396 SVENFYRLVTEGALDRETRAEYN---ITITITDLGTPRLKTEQS-ITVLVSDVNDNAPAF 451
Query: 307 EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
Y + + EN + V ATD+D G N + TY L P+
Sbjct: 452 TQTSYTLFVRENNSPALHIGSVRATDRDSGTNAQVTYSLLPPQ 494
Score = 42.3 bits (95), Expect = 0.013
Identities = 47/171 (27%), Positives = 72/171 (42%), Gaps = 12/171 (7%)
Query: 220 AIDQDLGVG--ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
A D LGVG A ++S ++ + LD G L L ++LD + ++ Q
Sbjct: 49 ANDLGLGVGELAERGARVVSEDNEQGLQLDLQTGQLILNEKLDREKLCG-PTEPCIMHFQ 107
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
L PL+ +A E+ + D+ND+ PEF + I E G A D D G
Sbjct: 108 VL-LKKPLEVFRA--ELLVTDINDHSPEFPEREMTLKIPETSSLGTVFPLKKARDLDVGS 164
Query: 338 NGEFTYQLDDPKGAFSIDPRS-----GWLTVRNQTVLDREAHSSLRMKVYA 383
N Y + P F + R+ + + T LDRE + LR+ + A
Sbjct: 165 NNVQNYNI-SPNSHFHVSTRTRGDGRKYPELVLDTELDREEQAELRLTLTA 214
Score = 40.3 bits (90), Expect = 0.052
Identities = 37/126 (29%), Positives = 54/126 (42%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 541 LSSEALVRVLVLDANDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 599
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + + + N T + + +H L V D P +L
Sbjct: 600 AWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDV-AKHRLVVLVKDNGEPPRSATATL 658
Query: 553 AVVTIE 558
V+ ++
Sbjct: 659 QVLLVD 664
Score = 36.3 bits (80), Expect = 0.85
Identities = 63/251 (25%), Positives = 101/251 (40%), Gaps = 38/251 (15%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPY------------HV----TVDELTPTGEKA 116
G ++ S+TV + DVNDN P F T Y H+ D + T +
Sbjct: 427 GTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVRATDRDSGTNAQV 486
Query: 117 FIFLIAPIGPSLTIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALES 176
L+ P P L PLT + + F + V D G AL S
Sbjct: 487 TYSLLPPQDPHL--PLTSLVSINT-DNGHLFALQSLDYEALQAFEFRVGATDRGFPALSS 543
Query: 177 SHKPVLLLRKVLDYDAGDKE-FQLVIMASGKRIHKEIL--FPEP------IHAIDQDLGV 227
L +VL DA D F L + +G E++ EP + A+D D G
Sbjct: 544 E-----ALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQ 598
Query: 228 GATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKT 287
A L Y+L+ + LF + + NG + + L +E ++ + V+ V+ + P ++
Sbjct: 599 NAWLSYQLLKATEPGLFGVWAHNGEV---RTARLLSERDVAKHRLVVLVKDN--GEPPRS 653
Query: 288 AQARVEIELLD 298
A A +++ L+D
Sbjct: 654 ATATLQVLLVD 664
>AF217742-1|AAK51610.1| 787|Homo sapiens protocadherin-beta15
protein.
Length = 787
Score = 113 bits (271), Expect = 6e-24
Identities = 116/462 (25%), Positives = 198/462 (42%), Gaps = 38/462 (8%)
Query: 446 EVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNL 505
E+ + D ND++P F P + + +GTV KA D D+G N + Y++ S+
Sbjct: 120 ELLVTDINDHSPEF-PEREMTLKIPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNSHF 178
Query: 506 TITSPFKINPNTGTVSVAESPILEGRHA---LFVEASDQPANPSERRYSLAVVTIEVTRG 562
+++ + + V ++ + A L + A D + P + ++ ++
Sbjct: 179 HVSTRTRGDGRKYPELVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDAN-- 236
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLHGYEE-GVP 619
+ P+F+ A YE V N +G+ V ++ D ++SY L + +E P
Sbjct: 237 -----DNAPEFVQALYEVQVPENSPVGSLVVKVSARDLDTGTNGEISYSLYYSSQEIDKP 291
Query: 620 FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKG 679
F + SG I ++ L YD + A + LS + +V V+DVND L
Sbjct: 292 FELSSLSGEIRLIKKLDFETMSSYDLDIEA-SDGGGLSGKCSVSVKVLDVNDNFPEL--- 347
Query: 680 AHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDG--T 737
+ S + + ENS + +F NG + + + Q DV + + +
Sbjct: 348 SISSLTSPIPENSPETEVA-LFRIRDRDSGENG----KMICSIQDDVPFKLKPSVENFYR 402
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
+ T+ LDRE R Y +T+ + G +T+ + D NDN P F +Y F+
Sbjct: 403 LVTEGALDRETRAEYNITITIT-DLGTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLFVR 461
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDENTGVVKFIGD 851
EN+ I + ATD D GTNA Y+L + ++ + G + F
Sbjct: 462 ENNSPALHI---GSVSATDRDSGTNAQVTYSLLPPRDPHLPLTSLVSINTDNGHL-FALQ 517
Query: 852 SLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 518 SLDYEALQAFEFRVGATDRGFPALSSEALVRVLVLDANDNSP 559
Score = 98.7 bits (235), Expect = 1e-19
Identities = 123/493 (24%), Positives = 200/493 (40%), Gaps = 63/493 (12%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEF--NSEVYIPPSKLSADALEVKRYFVINER 997
IPE +GT A DLD G N Y NS ++ ++ D + + E
Sbjct: 142 IPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNSHFHV-STRTRGDGRKYPELVLDTE- 199
Query: 998 HGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
++E RL ++A+DGG+ + + + + V D ND+ P F + Y V
Sbjct: 200 -------LDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNAPEFVQALYEVQVP 252
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTY--FIQPSDTDLPFEISPLTGVLSVNGELDRETE 1113
E ++ KV A D D G N ++Y + + D PFE+S L+G + + +LD ET
Sbjct: 253 ENSPVGSLVVKVSARDLDTGTNGEISYSLYYSSQEIDKPFELSSLSGEIRLIKKLDFETM 312
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK--FYAFDELLEWKHPEADEL--- 1168
Y L + A D G DVNDN P+ + + PE +
Sbjct: 313 SSYDLDIEASDGG---GLSGKCSVSVKVLDVNDNFPELSISSLTSPIPENSPETEVALFR 369
Query: 1169 --SNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQ 1224
+ E+ MI +I+++ P + +V + T+ + Y++
Sbjct: 370 IRDRDSGENGKMI----CSIQDDVPFKLKPSVENFYRLVTEGALDRETRAEYNI--TITI 423
Query: 1225 QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEH 1284
+LG P L + + V V+DV D + P F Y L + EN + + + S++ T+
Sbjct: 424 TDLGTPRLKTEQSITVLVSDVND-----NAPAFTQTSYTLFVRENNSPALHIGSVSATDR 478
Query: 1285 YE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREVKDTYEVIVRAERQKY 1340
N ++ Y +L D + T + I+ NG L+ ++S D E +E V A
Sbjct: 479 DSGTNAQVTYSLLPPRDPHLPLTSLVSINTDNGHLFALQSLDYEALQAFEFRVGAT---- 534
Query: 1341 SRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTNGNRPLVTAIPTTAP 1396
R P + + V V + D NDNSP NG+ P +P A
Sbjct: 535 DRGFPAL-------------SSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAE 581
Query: 1397 FGYQVMQLKGAIG 1409
GY V ++ G
Sbjct: 582 PGYLVTKVVAVDG 594
Score = 83.8 bits (198), Expect = 4e-15
Identities = 53/154 (34%), Positives = 81/154 (52%), Gaps = 8/154 (5%)
Query: 744 LDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIG 803
LDRE++ R+T+ A + G +G Q+ I + D NDN P F A YE + ENS +G
Sbjct: 200 LDREEQAELRLTLTA-VDGGSPPRSGTVQILILVLDANDNAPEFVQALYEVQVPENSPVG 258
Query: 804 TEIKMDNIIKATDADEGTNALFMYTLFGEGKEM---FDVDENTGVVKFIGDSLDREKKIM 860
+ + + A D D GTN Y+L+ +E+ F++ +G ++ I LD E
Sbjct: 259 SLVVK---VSARDLDTGTNGEISYSLYYSSQEIDKPFELSSLSGEIRLI-KKLDFETMSS 314
Query: 861 YKLSLVARDTGGLSSEAELIIMIGDENDNKPEFN 894
Y L + A D GGLS + + + + D NDN PE +
Sbjct: 315 YDLDIEASDGGGLSGKCSVSVKVLDVNDNFPELS 348
Score = 79.0 bits (186), Expect = 1e-13
Identities = 108/460 (23%), Positives = 193/460 (41%), Gaps = 38/460 (8%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V + + +LDANDN P FV + LYE + N+ VG+++ KV A D D G NG + Y L +
Sbjct: 226 VQILILVLDANDNAPEFVQA-LYEVQVPENSPVGSLVVKVSARDLDTGTNGEISYSLYYS 284
Query: 503 SNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIEVT 560
S I PF+++ +G + + + E + L +EASD + S++V ++V
Sbjct: 285 SQ-EIDKPFELSSLSGEIRLIKKLDFETMSSYDLDIEASD--GGGLSGKCSVSVKVLDV- 340
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P+ + + N T V R+ D + + ++ ++ VPF
Sbjct: 341 ------NDNFPELSISSLTSPIPEN-SPETEVALFRIRD--RDSGENGKMICSIQDDVPF 391
Query: 621 AVE---ERSGVITVVDDLSRYNRPMYDFE-AVALQENANLSIVTNATVHVVDVNDERGVL 676
++ E + L R R Y+ + L + TV V DVND
Sbjct: 392 KLKPSVENFYRLVTEGALDRETRAEYNITITITDLGTPRLKTEQSITVLVSDVNDNAPAF 451
Query: 677 LKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD----VTDDIAI 732
+ +++ +F + NS IG + T+ S V + + +D +T ++I
Sbjct: 452 TQTSYT--LFVRENNSPALHIGSVSATDRDS---GTNAQVTYSLLPPRDPHLPLTSLVSI 506
Query: 733 -AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
++G +F + LD E + V A ++G + + V + + D NDN P +
Sbjct: 507 NTDNGHLFALQSLDYEALQAFEFRVGAT-DRGFPALSSEALVRVLVLDANDNSPFVLYPL 565
Query: 792 YEGFIMENSKIGTEIKMDNIIK---ATDADEGTNALFMYTLFGEGKE-MFDVDENTGVVK 847
G + + ++ A D D G NA Y L + +F V + G V+
Sbjct: 566 QNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVR 625
Query: 848 FIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
L ++L ++ +D G S+ A L +++ D
Sbjct: 626 -TARLLSERDVAKHRLVVLVKDNGEPPRSATATLQVLLVD 664
Score = 63.3 bits (147), Expect = 6e-09
Identities = 49/170 (28%), Positives = 76/170 (44%), Gaps = 7/170 (4%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D+G Y + + + + +G + E LD + + QA L + A
Sbjct: 157 ARDLDVGSNNVQNYNISPNSHFHVSTRTRGDGRKYPELVLDTELDREEQAE-LRLTLTAV 215
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
+P ++ ++ I +LD NDN PEF Y + + EN P G V++V A D D G NG
Sbjct: 216 DGGSPPRSGTVQILILVLDANDNAPEFVQALYEVQVPENSPVGSLVVKVSARDLDTGTNG 275
Query: 340 EFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
E +Y L + F + SG +R LD E SS + + A +
Sbjct: 276 EISYSLYYSSQEIDKPFELSSLSG--EIRLIKKLDFETMSSYDLDIEASD 323
Score = 59.7 bits (138), Expect = 8e-08
Identities = 56/181 (30%), Positives = 84/181 (46%), Gaps = 20/181 (11%)
Query: 218 IHAIDQDLGVGATLRYELISGND-----RKLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A D+D G A + Y L+ D L S+++ NG LF + LD +A LQA F
Sbjct: 473 VSATDRDSGTNAQVTYSLLPPRDPHLPLTSLVSINTDNGHLFALQSLDYEA---LQA--F 527
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISI--VENLPN----GFSVL 326
+V A+ P +++A V + +LD NDN P N S E +P G+ V
Sbjct: 528 EFRVGATDRGFPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVT 587
Query: 327 QVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAK 384
+V+A D D G+N +YQL G F + +G VR +L + R+ V K
Sbjct: 588 KVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG--EVRTARLLSERDVAKHRLVVLVK 645
Query: 385 E 385
+
Sbjct: 646 D 646
Score = 58.8 bits (136), Expect = 1e-07
Identities = 44/167 (26%), Positives = 74/167 (44%), Gaps = 12/167 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR--KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A D D G + Y L + K F L S++G + L K+LD + +++ L
Sbjct: 264 VSARDLDTGTNGEISYSLYYSSQEIDKPFELSSLSGEIRLIKKLDFET-----MSSYDLD 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
++AS + + V +++LD+NDN PE + I EN P V D+D
Sbjct: 319 IEASDGGG--LSGKCSVSVKVLDVNDNFPELSISSLTSPIPENSPE-TEVALFRIRDRDS 375
Query: 336 GENGEFTYQLDDPKGAFSIDPR-SGWLTVRNQTVLDREAHSSLRMKV 381
GENG+ + D F + P + + + LDRE + + +
Sbjct: 376 GENGKMICSIQDDV-PFKLKPSVENFYRLVTEGALDRETRAEYNITI 421
Score = 55.2 bits (127), Expect = 2e-06
Identities = 58/200 (29%), Positives = 83/200 (41%), Gaps = 19/200 (9%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
LF+ N P I ++A D DSG N Q+ Y +PP L + IN
Sbjct: 458 LFVRENNSP-ALHIGSVSATDRDSGTNAQVTYSL-----LPPRD---PHLPLTSLVSINT 508
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+GH+ +SL E+ F + A D G L+ VRV V D ND+ P N
Sbjct: 509 DNGHLFALQSLDYEALQAFEFRVGATDRGFPALSSEALVRVLVLDANDNSPFVLYPLQNG 568
Query: 1053 NVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
+ + R ++ KV A D D GQNA L+Y + + F + G +
Sbjct: 569 SAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTAR 628
Query: 1107 ELDRETEDKYILTVVARDNG 1126
L K+ L V+ +DNG
Sbjct: 629 LLSERDVAKHRLVVLVKDNG 648
Score = 54.4 bits (125), Expect = 3e-06
Identities = 48/180 (26%), Positives = 77/180 (42%), Gaps = 12/180 (6%)
Query: 722 NQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
N+Q + D+ + G + + LDREK I F + +++ + + D N
Sbjct: 71 NEQGLQLDL---QTGQLILNEKLDREKLCGPTEPCIMHFQVLLKKPLEVFRAELLVTDIN 127
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDE 841
D+ P F I E S +GT + KA D D G+N + Y +
Sbjct: 128 DHSPEFPEREMTLKIPETSSLGTVFPLK---KARDLDVGSNNVQNYNISPNSHFHVSTRT 184
Query: 842 NTGVVKF----IGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
K+ + LDRE++ +L+L A D G S +++I++ D NDN PEF Q
Sbjct: 185 RGDGRKYPELVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNAPEFVQ 244
Score = 51.6 bits (118), Expect = 2e-05
Identities = 84/368 (22%), Positives = 142/368 (38%), Gaps = 55/368 (14%)
Query: 1033 VFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP 1092
+ V D+NDH P F + + E V A D D G N Y I P+
Sbjct: 121 LLVTDINDHSPEFPEREMTLKIPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNS---H 177
Query: 1093 FEISPLT-------GVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
F +S T L ++ ELDRE + + LT+ A D G D N
Sbjct: 178 FHVSTRTRGDGRKYPELVLDTELDREEQAELRLTLTAVDGG-SPPRSGTVQILILVLDAN 236
Query: 1146 DNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTD 1205
DN+P+F L E + P EN+P+G+ V KV A D D
Sbjct: 237 DNAPEF--VQALYEVQVP------------------------ENSPVGSLVVKVSARDLD 270
Query: 1206 FIGNGNGLILYSL--PQRKNQQNLGLPSLSSTAILM-----VTVADVPDEVEMSDKPVFI 1258
NG I YSL ++ + L SLS L+ T++ ++E SD
Sbjct: 271 --TGTNGEISYSLYYSSQEIDKPFELSSLSGEIRLIKKLDFETMSSYDLDIEASDGGGLS 328
Query: 1259 SR----YYELEIEENV-NAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNG 1313
+ L++ +N + ++ + E+ ++ + + + D+ + ++
Sbjct: 329 GKCSVSVKVLDVNDNFPELSISSLTSPIPENSPETEVALFRIRDRDSGENGKMICSIQDD 388
Query: 1314 TLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDV 1373
+ ++ V++ Y ++ + +R + I D+ K + + V + DV
Sbjct: 389 VPFKLKP---SVENFYRLVTEGALDRETR-AEYNITITITDLGTPRLKTEQSITVLVSDV 444
Query: 1374 NDNSPKFT 1381
NDN+P FT
Sbjct: 445 NDNAPAFT 452
Score = 51.2 bits (117), Expect = 3e-05
Identities = 57/250 (22%), Positives = 100/250 (40%), Gaps = 16/250 (6%)
Query: 666 VVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRF-LIANQQ 724
V+D ND ++ + V ENS ++ + + + G + + L + Q
Sbjct: 232 VLDANDNAPEFVQALYE---VQVPENSPVGSL--VVKVSARDLDTGTNGEISYSLYYSSQ 286
Query: 725 DVTDDIAIAE-DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDN 783
++ ++ G I K LD E Y + + A G+ +G V++ + D NDN
Sbjct: 287 EIDKPFELSSLSGEIRLIKKLDFETMSSYDLDIEASDGGGL---SGKCSVSVKVLDVNDN 343
Query: 784 PPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENT 843
P ++ I ENS TE+ + I D D G N + ++ +
Sbjct: 344 FPELSISSLTSPIPENSP-ETEVALFRI---RDRDSGENGKMICSIQDDVPFKLKPSVEN 399
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSK 901
+LDRE + Y +++ D G L +E + +++ D NDN P F Q
Sbjct: 400 FYRLVTEGALDRETRAEYNITITITDLGTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLF 459
Query: 902 VRIHRETKLN 911
VR + L+
Sbjct: 460 VRENNSPALH 469
Score = 50.0 bits (114), Expect = 6e-05
Identities = 34/103 (33%), Positives = 49/103 (47%), Gaps = 5/103 (4%)
Query: 248 SVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNP-LKTAQARVEIELLDLNDNLPEF 306
SV L E LD E + N + + + L P LKT Q+ + + + D+NDN P F
Sbjct: 396 SVENFYRLVTEGALDRETRAEYN---ITITITDLGTPRLKTEQS-ITVLVSDVNDNAPAF 451
Query: 307 EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
Y + + EN + V ATD+D G N + TY L P+
Sbjct: 452 TQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPR 494
Score = 42.3 bits (95), Expect = 0.013
Identities = 47/171 (27%), Positives = 72/171 (42%), Gaps = 12/171 (7%)
Query: 220 AIDQDLGVG--ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
A D LGVG A ++S ++ + LD G L L ++LD + ++ Q
Sbjct: 49 ANDLGLGVGELAERGARVVSEDNEQGLQLDLQTGQLILNEKLDREKLCG-PTEPCIMHFQ 107
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
L PL+ +A E+ + D+ND+ PEF + I E G A D D G
Sbjct: 108 VL-LKKPLEVFRA--ELLVTDINDHSPEFPEREMTLKIPETSSLGTVFPLKKARDLDVGS 164
Query: 338 NGEFTYQLDDPKGAFSIDPRS-----GWLTVRNQTVLDREAHSSLRMKVYA 383
N Y + P F + R+ + + T LDRE + LR+ + A
Sbjct: 165 NNVQNYNI-SPNSHFHVSTRTRGDGRKYPELVLDTELDREEQAELRLTLTA 214
Score = 40.3 bits (90), Expect = 0.052
Identities = 37/126 (29%), Positives = 54/126 (42%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 541 LSSEALVRVLVLDANDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 599
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + + + N T + + +H L V D P +L
Sbjct: 600 AWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDV-AKHRLVVLVKDNGEPPRSATATL 658
Query: 553 AVVTIE 558
V+ ++
Sbjct: 659 QVLLVD 664
Score = 37.5 bits (83), Expect = 0.37
Identities = 64/248 (25%), Positives = 101/248 (40%), Gaps = 32/248 (12%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE-LTPT---GEKAFIFLIAPIGPSL 128
G ++ S+TV + DVNDN P F T Y + V E +P G + + +
Sbjct: 427 GTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQV 486
Query: 129 TIPLTVPRG----LTIFKDIRA-----FDRDKPNTPNSDVHYSIVSGNDDGHFALESSHK 179
T L PR LT I F + V D G AL S
Sbjct: 487 TYSLLPPRDPHLPLTSLVSINTDNGHLFALQSLDYEALQAFEFRVGATDRGFPALSSE-- 544
Query: 180 PVLLLRKVLDYDAGDKE-FQLVIMASGKRIHKEIL--FPEP------IHAIDQDLGVGAT 230
L +VL DA D F L + +G E++ EP + A+D D G A
Sbjct: 545 ---ALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAW 601
Query: 231 LRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQA 290
L Y+L+ + LF + + NG + + L +E ++ + V+ V+ + P ++A A
Sbjct: 602 LSYQLLKATEPGLFGVWAHNGEV---RTARLLSERDVAKHRLVVLVKDN--GEPPRSATA 656
Query: 291 RVEIELLD 298
+++ L+D
Sbjct: 657 TLQVLLVD 664
>AF152494-1|AAD43755.1| 787|Homo sapiens protocadherin beta 15
protein.
Length = 787
Score = 113 bits (271), Expect = 6e-24
Identities = 116/462 (25%), Positives = 198/462 (42%), Gaps = 38/462 (8%)
Query: 446 EVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNL 505
E+ + D ND++P F P + + +GTV KA D D+G N + Y++ S+
Sbjct: 120 ELLVTDINDHSPEF-PEREMTLKIPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNSHF 178
Query: 506 TITSPFKINPNTGTVSVAESPILEGRHA---LFVEASDQPANPSERRYSLAVVTIEVTRG 562
+++ + + V ++ + A L + A D + P + ++ ++
Sbjct: 179 HVSTRTRGDGRKYPELVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDAN-- 236
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLLHGYEE-GVP 619
+ P+F+ A YE V N +G+ V ++ D ++SY L + +E P
Sbjct: 237 -----DNAPEFVQALYEVQVPENSPVGSLVVKVSARDLDTGTNGEISYSLYYSSQEIDKP 291
Query: 620 FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKG 679
F + SG I ++ L YD + A + LS + +V V+DVND L
Sbjct: 292 FELSSLSGEIRLIKKLDFETMSSYDLDIEA-SDGGGLSGKCSVSVKVLDVNDNFPEL--- 347
Query: 680 AHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDG--T 737
+ S + + ENS + +F NG + + + Q DV + + +
Sbjct: 348 SISSLTSPIPENSPETEVA-LFRIRDRDSGENG----KMICSIQDDVPFKLKPSVENFYR 402
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
+ T+ LDRE R Y +T+ + G +T+ + D NDN P F +Y F+
Sbjct: 403 LVTEGALDRETRAEYNITITIT-DLGTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLFVR 461
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDENTGVVKFIGD 851
EN+ I + ATD D GTNA Y+L + ++ + G + F
Sbjct: 462 ENNSPALHI---GSVSATDRDSGTNAQVTYSLLPPRDPHLPLTSLVSINTDNGHL-FALQ 517
Query: 852 SLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 518 SLDYEALQAFEFRVGATDRGFPALSSEALVRVLVLDANDNSP 559
Score = 98.7 bits (235), Expect = 1e-19
Identities = 123/493 (24%), Positives = 200/493 (40%), Gaps = 63/493 (12%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEF--NSEVYIPPSKLSADALEVKRYFVINER 997
IPE +GT A DLD G N Y NS ++ ++ D + + E
Sbjct: 142 IPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNSHFHV-STRTRGDGRKYPELVLDTE- 199
Query: 998 HGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
++E RL ++A+DGG+ + + + + V D ND+ P F + Y V
Sbjct: 200 -------LDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNAPEFVQALYEVQVP 252
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTY--FIQPSDTDLPFEISPLTGVLSVNGELDRETE 1113
E ++ KV A D D G N ++Y + + D PFE+S L+G + + +LD ET
Sbjct: 253 ENSPVGSLVVKVSARDLDTGTNGEISYSLYYSSQEIDKPFELSSLSGEIRLIKKLDFETM 312
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK--FYAFDELLEWKHPEADEL--- 1168
Y L + A D G DVNDN P+ + + PE +
Sbjct: 313 SSYDLDIEASDGG---GLSGKCSVSVKVLDVNDNFPELSISSLTSPIPENSPETEVALFR 369
Query: 1169 --SNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQ 1224
+ E+ MI +I+++ P + +V + T+ + Y++
Sbjct: 370 IRDRDSGENGKMI----CSIQDDVPFKLKPSVENFYRLVTEGALDRETRAEYNI--TITI 423
Query: 1225 QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEH 1284
+LG P L + + V V+DV D + P F Y L + EN + + + S++ T+
Sbjct: 424 TDLGTPRLKTEQSITVLVSDVND-----NAPAFTQTSYTLFVRENNSPALHIGSVSATDR 478
Query: 1285 YE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREVKDTYEVIVRAERQKY 1340
N ++ Y +L D + T + I+ NG L+ ++S D E +E V A
Sbjct: 479 DSGTNAQVTYSLLPPRDPHLPLTSLVSINTDNGHLFALQSLDYEALQAFEFRVGAT---- 534
Query: 1341 SRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTNGNRPLVTAIPTTAP 1396
R P + + V V + D NDNSP NG+ P +P A
Sbjct: 535 DRGFPAL-------------SSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAE 581
Query: 1397 FGYQVMQLKGAIG 1409
GY V ++ G
Sbjct: 582 PGYLVTKVVAVDG 594
Score = 83.8 bits (198), Expect = 4e-15
Identities = 53/154 (34%), Positives = 81/154 (52%), Gaps = 8/154 (5%)
Query: 744 LDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIG 803
LDRE++ R+T+ A + G +G Q+ I + D NDN P F A YE + ENS +G
Sbjct: 200 LDREEQAELRLTLTA-VDGGSPPRSGTVQILILVLDANDNAPEFVQALYEVQVPENSPVG 258
Query: 804 TEIKMDNIIKATDADEGTNALFMYTLFGEGKEM---FDVDENTGVVKFIGDSLDREKKIM 860
+ + + A D D GTN Y+L+ +E+ F++ +G ++ I LD E
Sbjct: 259 SLVVK---VSARDLDTGTNGEISYSLYYSSQEIDKPFELSSLSGEIRLI-KKLDFETMSS 314
Query: 861 YKLSLVARDTGGLSSEAELIIMIGDENDNKPEFN 894
Y L + A D GGLS + + + + D NDN PE +
Sbjct: 315 YDLDIEASDGGGLSGKCSVSVKVLDVNDNFPELS 348
Score = 79.0 bits (186), Expect = 1e-13
Identities = 108/460 (23%), Positives = 193/460 (41%), Gaps = 38/460 (8%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V + + +LDANDN P FV + LYE + N+ VG+++ KV A D D G NG + Y L +
Sbjct: 226 VQILILVLDANDNAPEFVQA-LYEVQVPENSPVGSLVVKVSARDLDTGTNGEISYSLYYS 284
Query: 503 SNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIEVT 560
S I PF+++ +G + + + E + L +EASD + S++V ++V
Sbjct: 285 SQ-EIDKPFELSSLSGEIRLIKKLDFETMSSYDLDIEASD--GGGLSGKCSVSVKVLDV- 340
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
+ P+ + + N T V R+ D + + ++ ++ VPF
Sbjct: 341 ------NDNFPELSISSLTSPIPEN-SPETEVALFRIRD--RDSGENGKMICSIQDDVPF 391
Query: 621 AVE---ERSGVITVVDDLSRYNRPMYDFE-AVALQENANLSIVTNATVHVVDVNDERGVL 676
++ E + L R R Y+ + L + TV V DVND
Sbjct: 392 KLKPSVENFYRLVTEGALDRETRAEYNITITITDLGTPRLKTEQSITVLVSDVNDNAPAF 451
Query: 677 LKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD----VTDDIAI 732
+ +++ +F + NS IG + T+ S V + + +D +T ++I
Sbjct: 452 TQTSYT--LFVRENNSPALHIGSVSATDRDS---GTNAQVTYSLLPPRDPHLPLTSLVSI 506
Query: 733 -AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
++G +F + LD E + V A ++G + + V + + D NDN P +
Sbjct: 507 NTDNGHLFALQSLDYEALQAFEFRVGAT-DRGFPALSSEALVRVLVLDANDNSPFVLYPL 565
Query: 792 YEGFIMENSKIGTEIKMDNIIK---ATDADEGTNALFMYTLFGEGKE-MFDVDENTGVVK 847
G + + ++ A D D G NA Y L + +F V + G V+
Sbjct: 566 QNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVR 625
Query: 848 FIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
L ++L ++ +D G S+ A L +++ D
Sbjct: 626 -TARLLSERDVAKHRLVVLVKDNGEPPRSATATLQVLLVD 664
Score = 63.3 bits (147), Expect = 6e-09
Identities = 49/170 (28%), Positives = 76/170 (44%), Gaps = 7/170 (4%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D+G Y + + + + +G + E LD + + QA L + A
Sbjct: 157 ARDLDVGSNNVQNYNISPNSHFHVSTRTRGDGRKYPELVLDTELDREEQAE-LRLTLTAV 215
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
+P ++ ++ I +LD NDN PEF Y + + EN P G V++V A D D G NG
Sbjct: 216 DGGSPPRSGTVQILILVLDANDNAPEFVQALYEVQVPENSPVGSLVVKVSARDLDTGTNG 275
Query: 340 EFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
E +Y L + F + SG +R LD E SS + + A +
Sbjct: 276 EISYSLYYSSQEIDKPFELSSLSG--EIRLIKKLDFETMSSYDLDIEASD 323
Score = 59.7 bits (138), Expect = 8e-08
Identities = 56/181 (30%), Positives = 84/181 (46%), Gaps = 20/181 (11%)
Query: 218 IHAIDQDLGVGATLRYELISGND-----RKLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A D+D G A + Y L+ D L S+++ NG LF + LD +A LQA F
Sbjct: 473 VSATDRDSGTNAQVTYSLLPPRDPHLPLTSLVSINTDNGHLFALQSLDYEA---LQA--F 527
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISI--VENLPN----GFSVL 326
+V A+ P +++A V + +LD NDN P N S E +P G+ V
Sbjct: 528 EFRVGATDRGFPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVT 587
Query: 327 QVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAK 384
+V+A D D G+N +YQL G F + +G VR +L + R+ V K
Sbjct: 588 KVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG--EVRTARLLSERDVAKHRLVVLVK 645
Query: 385 E 385
+
Sbjct: 646 D 646
Score = 58.8 bits (136), Expect = 1e-07
Identities = 44/167 (26%), Positives = 74/167 (44%), Gaps = 12/167 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR--KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A D D G + Y L + K F L S++G + L K+LD + +++ L
Sbjct: 264 VSARDLDTGTNGEISYSLYYSSQEIDKPFELSSLSGEIRLIKKLDFET-----MSSYDLD 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
++AS + + V +++LD+NDN PE + I EN P V D+D
Sbjct: 319 IEASDGGG--LSGKCSVSVKVLDVNDNFPELSISSLTSPIPENSPE-TEVALFRIRDRDS 375
Query: 336 GENGEFTYQLDDPKGAFSIDPR-SGWLTVRNQTVLDREAHSSLRMKV 381
GENG+ + D F + P + + + LDRE + + +
Sbjct: 376 GENGKMICSIQDDV-PFKLKPSVENFYRLVTEGALDRETRAEYNITI 421
Score = 55.2 bits (127), Expect = 2e-06
Identities = 58/200 (29%), Positives = 83/200 (41%), Gaps = 19/200 (9%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
LF+ N P I ++A D DSG N Q+ Y +PP L + IN
Sbjct: 458 LFVRENNSP-ALHIGSVSATDRDSGTNAQVTYSL-----LPPRD---PHLPLTSLVSINT 508
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+GH+ +SL E+ F + A D G L+ VRV V D ND+ P N
Sbjct: 509 DNGHLFALQSLDYEALQAFEFRVGATDRGFPALSSEALVRVLVLDANDNSPFVLYPLQNG 568
Query: 1053 NVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
+ + R ++ KV A D D GQNA L+Y + + F + G +
Sbjct: 569 SAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTAR 628
Query: 1107 ELDRETEDKYILTVVARDNG 1126
L K+ L V+ +DNG
Sbjct: 629 LLSERDVAKHRLVVLVKDNG 648
Score = 54.4 bits (125), Expect = 3e-06
Identities = 48/180 (26%), Positives = 77/180 (42%), Gaps = 12/180 (6%)
Query: 722 NQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
N+Q + D+ + G + + LDREK I F + +++ + + D N
Sbjct: 71 NEQGLQLDL---QTGQLILNEKLDREKLCGPTEPCIMHFQVLLKKPLEVFRAELLVTDIN 127
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDE 841
D+ P F I E S +GT + KA D D G+N + Y +
Sbjct: 128 DHSPEFPEREMTLKIPETSSLGTVFPLK---KARDLDVGSNNVQNYNISPNSHFHVSTRT 184
Query: 842 NTGVVKF----IGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
K+ + LDRE++ +L+L A D G S +++I++ D NDN PEF Q
Sbjct: 185 RGDGRKYPELVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNAPEFVQ 244
Score = 51.6 bits (118), Expect = 2e-05
Identities = 84/368 (22%), Positives = 142/368 (38%), Gaps = 55/368 (14%)
Query: 1033 VFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP 1092
+ V D+NDH P F + + E V A D D G N Y I P+
Sbjct: 121 LLVTDINDHSPEFPEREMTLKIPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNS---H 177
Query: 1093 FEISPLT-------GVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
F +S T L ++ ELDRE + + LT+ A D G D N
Sbjct: 178 FHVSTRTRGDGRKYPELVLDTELDREEQAELRLTLTAVDGG-SPPRSGTVQILILVLDAN 236
Query: 1146 DNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTD 1205
DN+P+F L E + P EN+P+G+ V KV A D D
Sbjct: 237 DNAPEF--VQALYEVQVP------------------------ENSPVGSLVVKVSARDLD 270
Query: 1206 FIGNGNGLILYSL--PQRKNQQNLGLPSLSSTAILM-----VTVADVPDEVEMSDKPVFI 1258
NG I YSL ++ + L SLS L+ T++ ++E SD
Sbjct: 271 --TGTNGEISYSLYYSSQEIDKPFELSSLSGEIRLIKKLDFETMSSYDLDIEASDGGGLS 328
Query: 1259 SR----YYELEIEENV-NAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNG 1313
+ L++ +N + ++ + E+ ++ + + + D+ + ++
Sbjct: 329 GKCSVSVKVLDVNDNFPELSISSLTSPIPENSPETEVALFRIRDRDSGENGKMICSIQDD 388
Query: 1314 TLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDV 1373
+ ++ V++ Y ++ + +R + I D+ K + + V + DV
Sbjct: 389 VPFKLKP---SVENFYRLVTEGALDRETR-AEYNITITITDLGTPRLKTEQSITVLVSDV 444
Query: 1374 NDNSPKFT 1381
NDN+P FT
Sbjct: 445 NDNAPAFT 452
Score = 51.2 bits (117), Expect = 3e-05
Identities = 57/250 (22%), Positives = 100/250 (40%), Gaps = 16/250 (6%)
Query: 666 VVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRF-LIANQQ 724
V+D ND ++ + V ENS ++ + + + G + + L + Q
Sbjct: 232 VLDANDNAPEFVQALYE---VQVPENSPVGSL--VVKVSARDLDTGTNGEISYSLYYSSQ 286
Query: 725 DVTDDIAIAE-DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDN 783
++ ++ G I K LD E Y + + A G+ +G V++ + D NDN
Sbjct: 287 EIDKPFELSSLSGEIRLIKKLDFETMSSYDLDIEASDGGGL---SGKCSVSVKVLDVNDN 343
Query: 784 PPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENT 843
P ++ I ENS TE+ + I D D G N + ++ +
Sbjct: 344 FPELSISSLTSPIPENSP-ETEVALFRI---RDRDSGENGKMICSIQDDVPFKLKPSVEN 399
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSK 901
+LDRE + Y +++ D G L +E + +++ D NDN P F Q
Sbjct: 400 FYRLVTEGALDRETRAEYNITITITDLGTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLF 459
Query: 902 VRIHRETKLN 911
VR + L+
Sbjct: 460 VRENNSPALH 469
Score = 50.0 bits (114), Expect = 6e-05
Identities = 34/103 (33%), Positives = 49/103 (47%), Gaps = 5/103 (4%)
Query: 248 SVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNP-LKTAQARVEIELLDLNDNLPEF 306
SV L E LD E + N + + + L P LKT Q+ + + + D+NDN P F
Sbjct: 396 SVENFYRLVTEGALDRETRAEYN---ITITITDLGTPRLKTEQS-ITVLVSDVNDNAPAF 451
Query: 307 EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
Y + + EN + V ATD+D G N + TY L P+
Sbjct: 452 TQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPR 494
Score = 42.3 bits (95), Expect = 0.013
Identities = 47/171 (27%), Positives = 72/171 (42%), Gaps = 12/171 (7%)
Query: 220 AIDQDLGVG--ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
A D LGVG A ++S ++ + LD G L L ++LD + ++ Q
Sbjct: 49 ANDLGLGVGELAERGARVVSEDNEQGLQLDLQTGQLILNEKLDREKLCG-PTEPCIMHFQ 107
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
L PL+ +A E+ + D+ND+ PEF + I E G A D D G
Sbjct: 108 VL-LKKPLEVFRA--ELLVTDINDHSPEFPEREMTLKIPETSSLGTVFPLKKARDLDVGS 164
Query: 338 NGEFTYQLDDPKGAFSIDPRS-----GWLTVRNQTVLDREAHSSLRMKVYA 383
N Y + P F + R+ + + T LDRE + LR+ + A
Sbjct: 165 NNVQNYNI-SPNSHFHVSTRTRGDGRKYPELVLDTELDREEQAELRLTLTA 214
Score = 40.3 bits (90), Expect = 0.052
Identities = 37/126 (29%), Positives = 54/126 (42%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 541 LSSEALVRVLVLDANDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 599
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + + + N T + + +H L V D P +L
Sbjct: 600 AWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDV-AKHRLVVLVKDNGEPPRSATATL 658
Query: 553 AVVTIE 558
V+ ++
Sbjct: 659 QVLLVD 664
Score = 37.5 bits (83), Expect = 0.37
Identities = 64/248 (25%), Positives = 101/248 (40%), Gaps = 32/248 (12%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE-LTPT---GEKAFIFLIAPIGPSL 128
G ++ S+TV + DVNDN P F T Y + V E +P G + + +
Sbjct: 427 GTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQV 486
Query: 129 TIPLTVPRG----LTIFKDIRA-----FDRDKPNTPNSDVHYSIVSGNDDGHFALESSHK 179
T L PR LT I F + V D G AL S
Sbjct: 487 TYSLLPPRDPHLPLTSLVSINTDNGHLFALQSLDYEALQAFEFRVGATDRGFPALSSE-- 544
Query: 180 PVLLLRKVLDYDAGDKE-FQLVIMASGKRIHKEIL--FPEP------IHAIDQDLGVGAT 230
L +VL DA D F L + +G E++ EP + A+D D G A
Sbjct: 545 ---ALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAW 601
Query: 231 LRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQA 290
L Y+L+ + LF + + NG + + L +E ++ + V+ V+ + P ++A A
Sbjct: 602 LSYQLLKATEPGLFGVWAHNGEV---RTARLLSERDVAKHRLVVLVKDN--GEPPRSATA 656
Query: 291 RVEIELLD 298
+++ L+D
Sbjct: 657 TLQVLLVD 664
>BC104817-1|AAI04818.1| 796|Homo sapiens protocadherin beta 3
protein.
Length = 796
Score = 112 bits (269), Expect = 1e-23
Identities = 122/467 (26%), Positives = 203/467 (43%), Gaps = 36/467 (7%)
Query: 440 MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
+ FV E+ ++D ND++PVF + ++ ++S GTVI A D D+G+N + Y +
Sbjct: 114 LQFVTNELRIIDVNDHSPVFFENEMHLKILESTLP-GTVIPLGNAEDLDVGRNSLQNYTI 172
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLAVVT 556
S+ + + + + V + + + +L + A D + P R A +
Sbjct: 173 TPNSHFHVLTRSRRDGRKYPELVLDKALDREEQPELSLTLTALDGGSPP---RSGTAQIN 229
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN--DAFEQNDVSYDLLHGY 614
I+V + P+F YE V N + + + + + D +SY H
Sbjct: 230 IQVL----DINDNAPEFAQPLYEVAVLENTPVNSVIVTVSASDLDTGSFGTISYAFFHAS 285
Query: 615 EE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDER 673
EE F + +G + +V L+ Y+ + + ++ LS + V VVDVND
Sbjct: 286 EEIRKTFQLNPITGDMQLVKYLNFEAINSYEVD-IEAKDGGGLSGKSTVIVQVVDVNDNP 344
Query: 674 GVL-LKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI 732
L L +SPI ENS G + +F ++S + G V I N ++
Sbjct: 345 PELTLSSVNSPI----PENS-GETVLAVF--SVSDLDSGDNGRVMCSIENNLPFFLKPSV 397
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
T+ ++ LDRE R Y +T+ + G Y +T+ + D NDN P F +Y
Sbjct: 398 ENFYTLVSEGALDRETRSEYNITITIT-DLGTPRLKTKYNITVLVSDVNDNAPAFTQTSY 456
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDENTGVV 846
F+ EN+ I + ATD D GTNA Y+L + ++ + G +
Sbjct: 457 TLFVRENNSPALHI---GSVSATDRDSGTNAQVTYSLLPPQDPHLPLSSLVSINADNGHL 513
Query: 847 KFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
F SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 514 -FALRSLDYEALQAFEFRVGAADRGSPALSSEALVRVLVLDANDNSP 559
Score = 80.6 bits (190), Expect = 4e-14
Identities = 58/222 (26%), Positives = 106/222 (47%), Gaps = 9/222 (4%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
K LDRE++ +T+ A + G +G Q+ I + D NDN P F YE ++EN+
Sbjct: 198 KALDREEQPELSLTLTA-LDGGSPPRSGTAQINIQVLDINDNAPEFAQPLYEVAVLENTP 256
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM---FDVDENTGVVKFIGDSLDREKK 858
+ + I + A+D D G+ Y F +E+ F ++ TG ++ + L+ E
Sbjct: 257 VNSVIVT---VSASDLDTGSFGTISYAFFHASEEIRKTFQLNPITGDMQLV-KYLNFEAI 312
Query: 859 IMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTI 918
Y++ + A+D GGLS ++ +I+ + D NDN PE NS + + + +
Sbjct: 313 NSYEVDIEAKDGGGLSGKSTVIVQVVDVNDNPPELTLSSVNSPIPENSGETVLAVFSVSD 372
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDS 960
++ + ++ P FL P ++ T++ ALD ++
Sbjct: 373 LDSGDNGRVMCSIENNLPFFLKP-SVENFYTLVSEGALDRET 413
Score = 77.8 bits (183), Expect = 3e-13
Identities = 120/497 (24%), Positives = 204/497 (41%), Gaps = 76/497 (15%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEF--NSEVYIPPSKLSADALEVKRYFVI 994
L ++ +P GT I NA DLD G N Y NS ++ L+ + ++Y
Sbjct: 140 LKILESTLP-GTVIPLGNAEDLDVGRNSLQNYTITPNSHFHV----LTRSRRDGRKY--- 191
Query: 995 NERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWY 1050
+++ ++L E E L ++ALDGG+ + + + V D+ND+ P F + Y
Sbjct: 192 ----PELVLDKALDREEQPELSLTLTALDGGSPPRSGTAQINIQVLDINDNAPEFAQPLY 247
Query: 1051 NFNVEEAQYTRRVLGKVDATDADFGQNANLTY--FIQPSDTDLPFEISPLTGVLSVNGEL 1108
V E V+ V A+D D G ++Y F + F+++P+TG + + L
Sbjct: 248 EVAVLENTPVNSVIVTVSASDLDTGSFGTISYAFFHASEEIRKTFQLNPITGDMQLVKYL 307
Query: 1109 DRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADEL 1168
+ E + Y + + A+D G DVNDN P+ L P +
Sbjct: 308 NFEAINSYEVDIEAKDGG---GLSGKSTVIVQVVDVNDNPPEL----TLSSVNSP----I 356
Query: 1169 SNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDF----IGNGNGLILYSLPQRKNQ 1224
++ E+V + V+ + ++ G + + N F + N L+ R+ +
Sbjct: 357 PENSGETV--LAVFSVSDLDSGDNGRVMCSIENNLPFFLKPSVENFYTLVSEGALDRETR 414
Query: 1225 Q---------NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVE 1275
+LG P L + + V V+DV D + P F Y L + EN + +
Sbjct: 415 SEYNITITITDLGTPRLKTKYNITVLVSDVND-----NAPAFTQTSYTLFVRENNSPALH 469
Query: 1276 LVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREVKDTYEV 1331
+ S++ T+ N ++ Y +L D + + + I+ NG L+ +RS D E +E
Sbjct: 470 IGSVSATDRDSGTNAQVTYSLLPPQDPHLPLSSLVSINADNGHLFALRSLDYEALQAFEF 529
Query: 1332 IVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTNGNRPL 1387
V A R P + + V V + D NDNSP NG+ P
Sbjct: 530 RVGAA----DRGSPAL-------------SSEALVRVLVLDANDNSPFVLYPLQNGSAPC 572
Query: 1388 VTAIPTTAPFGYQVMQL 1404
+P A GY V ++
Sbjct: 573 TELVPRAAEPGYLVTKV 589
Score = 76.2 bits (179), Expect = 9e-13
Identities = 69/235 (29%), Positives = 103/235 (43%), Gaps = 28/235 (11%)
Query: 929 LDVDQLGPLFLIP-------ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD++ P F P EN P+ + I+ ++A DLD+G G I Y F
Sbjct: 233 LDINDNAPEFAQPLYEVAVLENTPVNSVIVTVSASDLDTGSFGTISYAFFHA-------- 284
Query: 982 SADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGNLNDNISVRVFVKDVN 1039
+ E+++ F +N G + + + L E+ + ++I A DGG L+ +V V V DVN
Sbjct: 285 ---SEEIRKTFQLNPITGDMQLVKYLNFEAINSYEVDIEAKDGGGLSGKSTVIVQVVDVN 341
Query: 1040 DHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLT 1099
D+ P + N + E VL +D D G N + I + +LPF + P
Sbjct: 342 DNPPELTLSSVNSPIPE-NSGETVLAVFSVSDLDSGDNGRVMCSI---ENNLPFFLKPSV 397
Query: 1100 G---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
L G LDRET +Y +T+ D G DVNDN+P F
Sbjct: 398 ENFYTLVSEGALDRETRSEYNITITITDLG-TPRLKTKYNITVLVSDVNDNAPAF 451
Score = 72.5 bits (170), Expect = 1e-11
Identities = 106/457 (23%), Positives = 189/457 (41%), Gaps = 36/457 (7%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
+ + +LD NDN P F LYE ++ N V +VI V A D D G G + Y S
Sbjct: 228 INIQVLDINDNAPEFAQP-LYEVAVLENTPVNSVIVTVSASDLDTGSFGTISYAFFHASE 286
Query: 505 LTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRGTK 564
I F++NP TG + + + E ++ V+ + + ++ V ++V
Sbjct: 287 -EIRKTFQLNPITGDMQLVKYLNFEAINSYEVDIEAKDGGGLSGKSTVIVQVVDV----N 341
Query: 565 GNKPDIP-DFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVE 623
N P++ + +P + N G T + V+D + D + ++ E +PF ++
Sbjct: 342 DNPPELTLSSVNSP----IPENSG-ETVLAVFSVSD-LDSGD-NGRVMCSIENNLPFFLK 394
Query: 624 ER-SGVITVVDD--LSRYNRPMYDFE-AVALQENANLSIVTNATVHVVDVNDERGVLLKG 679
T+V + L R R Y+ + L N TV V DVND +
Sbjct: 395 PSVENFYTLVSEGALDRETRSEYNITITITDLGTPRLKTKYNITVLVSDVNDNAPAFTQT 454
Query: 680 AHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD----VTDDIAI-AE 734
+++ +F + NS IG + T+ S V + + QD ++ ++I A+
Sbjct: 455 SYT--LFVRENNSPALHIGSVSATDRDS---GTNAQVTYSLLPPQDPHLPLSSLVSINAD 509
Query: 735 DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEG 794
+G +F + LD E + V A ++G + + V + + D NDN P + G
Sbjct: 510 NGHLFALRSLDYEALQAFEFRVGAA-DRGSPALSSEALVRVLVLDANDNSPFVLYPLQNG 568
Query: 795 FIMENSKIGTEIKMDNIIK---ATDADEGTNALFMYTLFGEGKE-MFDVDENTGVVKFIG 850
+ + ++ A D+D G NA Y L + +F V + G V+
Sbjct: 569 SAPCTELVPRAAEPGYLVTKVVAVDSDSGQNAWLSYQLLKATEPGLFGVWAHNGEVR-TA 627
Query: 851 DSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
L ++L ++ +D G S+ A L +++ D
Sbjct: 628 RLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD 664
Score = 63.3 bits (147), Expect = 6e-09
Identities = 43/171 (25%), Positives = 83/171 (48%), Gaps = 7/171 (4%)
Query: 219 HAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQA 278
+A D D+G + Y + + + + +G + E LD + Q L + A
Sbjct: 156 NAEDLDVGRNSLQNYTITPNSHFHVLTRSRRDGRKYPELVLDKALDREEQPE-LSLTLTA 214
Query: 279 SQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGEN 338
+P ++ A++ I++LD+NDN PEF Y ++++EN P ++ V A+D D G
Sbjct: 215 LDGGSPPRSGTAQINIQVLDINDNAPEFAQPLYEVAVLENTPVNSVIVTVSASDLDTGSF 274
Query: 339 GEFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
G +Y ++ + F ++P +G ++ L+ EA +S + + AK+
Sbjct: 275 GTISYAFFHASEEIRKTFQLNPITG--DMQLVKYLNFEAINSYEVDIEAKD 323
Score = 62.9 bits (146), Expect = 9e-09
Identities = 56/181 (30%), Positives = 85/181 (46%), Gaps = 20/181 (11%)
Query: 218 IHAIDQDLGVGATLRYELISGND-----RKLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A D+D G A + Y L+ D L S+++ NG LF + LD +A LQA F
Sbjct: 473 VSATDRDSGTNAQVTYSLLPPQDPHLPLSSLVSINADNGHLFALRSLDYEA---LQA--F 527
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISI--VENLPN----GFSVL 326
+V A+ +P +++A V + +LD NDN P N S E +P G+ V
Sbjct: 528 EFRVGAADRGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVT 587
Query: 327 QVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAK 384
+V+A D D G+N +YQL G F + +G VR +L + R+ V K
Sbjct: 588 KVVAVDSDSGQNAWLSYQLLKATEPGLFGVWAHNG--EVRTARLLSERDAAKHRLVVLVK 645
Query: 385 E 385
+
Sbjct: 646 D 646
Score = 59.7 bits (138), Expect = 8e-08
Identities = 59/200 (29%), Positives = 85/200 (42%), Gaps = 19/200 (9%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
LF+ N P I ++A D DSG N Q+ Y +PP L + IN
Sbjct: 458 LFVRENNSP-ALHIGSVSATDRDSGTNAQVTYSL-----LPPQD---PHLPLSSLVSINA 508
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+GH+ RSL E+ F + A D G+ L+ VRV V D ND+ P N
Sbjct: 509 DNGHLFALRSLDYEALQAFEFRVGAADRGSPALSSEALVRVLVLDANDNSPFVLYPLQNG 568
Query: 1053 NVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
+ + R ++ KV A D+D GQNA L+Y + + F + G +
Sbjct: 569 SAPCTELVPRAAEPGYLVTKVVAVDSDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTAR 628
Query: 1107 ELDRETEDKYILTVVARDNG 1126
L K+ L V+ +DNG
Sbjct: 629 LLSERDAAKHRLVVLVKDNG 648
Score = 59.3 bits (137), Expect = 1e-07
Identities = 44/167 (26%), Positives = 81/167 (48%), Gaps = 12/167 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGND--RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A D D G T+ Y ++ RK F L+ + G + L K L+ +A N++ +
Sbjct: 264 VSASDLDTGSFGTISYAFFHASEEIRKTFQLNPITGDMQLVKYLNFEA-----INSYEVD 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA-TDKD 334
++A + ++ V ++++D+NDN PE + N I EN +G +VL V + +D D
Sbjct: 319 IEAKDGGG--LSGKSTVIVQVVDVNDNPPELTLSSVNSPIPEN--SGETVLAVFSVSDLD 374
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKV 381
G+NG +++ F + T+ ++ LDRE S + +
Sbjct: 375 SGDNGRVMCSIENNLPFFLKPSVENFYTLVSEGALDRETRSEYNITI 421
Score = 51.6 bits (118), Expect = 2e-05
Identities = 36/126 (28%), Positives = 52/126 (41%), Gaps = 3/126 (2%)
Query: 224 DLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNN 283
DL G R N+ F SV L E LD E + N + + + L
Sbjct: 372 DLDSGDNGRVMCSIENNLPFFLKPSVENFYTLVSEGALDRETRSEYN---ITITITDLGT 428
Query: 284 PLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTY 343
P + + + + D+NDN P F Y + + EN + V ATD+D G N + TY
Sbjct: 429 PRLKTKYNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTY 488
Query: 344 QLDDPK 349
L P+
Sbjct: 489 SLLPPQ 494
Score = 48.8 bits (111), Expect = 1e-04
Identities = 36/119 (30%), Positives = 53/119 (44%), Gaps = 5/119 (4%)
Query: 1037 DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEIS 1096
DVNDH PVF + + + E+ V+ +A D D G+N+ Y I P+ S
Sbjct: 125 DVNDHSPVFFENEMHLKILESTLPGTVIPLGNAEDLDVGRNSLQNYTITPNSHFHVLTRS 184
Query: 1097 PLTG----VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
G L ++ LDRE + + LT+ A D G D+NDN+P+F
Sbjct: 185 RRDGRKYPELVLDKALDREEQPELSLTLTALDGG-SPPRSGTAQINIQVLDINDNAPEF 242
Score = 48.4 bits (110), Expect = 2e-04
Identities = 42/172 (24%), Positives = 71/172 (41%), Gaps = 9/172 (5%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
K L+ E + Y + + A+ G+ +G V + + D NDNPP ++ I ENS
Sbjct: 305 KYLNFEAINSYEVDIEAKDGGGL---SGKSTVIVQVVDVNDNPPELTLSSVNSPIPENS- 360
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMY 861
G + + +D D G N M ++ +LDRE + Y
Sbjct: 361 -GETVLA--VFSVSDLDSGDNGRVMCSIENNLPFFLKPSVENFYTLVSEGALDRETRSEY 417
Query: 862 KLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
+++ D G L ++ + +++ D NDN P F Q VR + L+
Sbjct: 418 NITITITDLGTPRLKTKYNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALH 469
Score = 47.6 bits (108), Expect = 3e-04
Identities = 68/244 (27%), Positives = 104/244 (42%), Gaps = 20/244 (8%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L + N+ V + D NDN P F ++ Y ++ N IG V A D D G N V Y
Sbjct: 430 RLKTKYNITVLVSDVNDNAPAFTQTS-YTLFVRENNSPALHIGSVSATDRDSGTNAQVTY 488
Query: 498 DL--QRTSNLTITSPFKINPNTGTVSVAESPILEGRHA--LFVEASDQ--PANPSERRYS 551
L + +L ++S IN + G + S E A V A+D+ PA SE
Sbjct: 489 SLLPPQDPHLPLSSLVSINADNGHLFALRSLDYEALQAFEFRVGAADRGSPALSSE---- 544
Query: 552 LAVVTIEVTRGTKGNKPDI--PDFMG-APYEFWVGSNVGIGTSVGQIRV--NDAFEQNDV 606
A+V + V N P + P G AP V G V ++ +D+ + +
Sbjct: 545 -ALVRVLVL-DANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDSDSGQNAWL 602
Query: 607 SYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHV 666
SY LL E G+ F V +G + LS + + V +++N AT+HV
Sbjct: 603 SYQLLKATEPGL-FGVWAHNGEVRTARLLSERDAAKHRL-VVLVKDNGEPPRSATATLHV 660
Query: 667 VDVN 670
+ V+
Sbjct: 661 LLVD 664
Score = 39.5 bits (88), Expect = 0.091
Identities = 34/125 (27%), Positives = 58/125 (46%), Gaps = 5/125 (4%)
Query: 234 ELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVE 293
+++S +++ F L G L L ++LD + E +L Q L NPL+ E
Sbjct: 65 QVVSKGNKQHFQLSHQTGDLLLNEKLDRE-ELCGPTEPCILHFQIL-LQNPLQFVTN--E 120
Query: 294 IELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFS 353
+ ++D+ND+ P F + ++ I+E+ G + A D D G N Y + P F
Sbjct: 121 LRIIDVNDHSPVFFENEMHLKILESTLPGTVIPLGNAEDLDVGRNSLQNYTI-TPNSHFH 179
Query: 354 IDPRS 358
+ RS
Sbjct: 180 VLTRS 184
Score = 33.5 bits (73), Expect = 6.0
Identities = 57/244 (23%), Positives = 102/244 (41%), Gaps = 24/244 (9%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE-LTPT---GEKAFIFLIAPIGPSL 128
G ++ ++TV + DVNDN P F T Y + V E +P G + + +
Sbjct: 427 GTPRLKTKYNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQV 486
Query: 129 TIPLTVPRGLTI-FKDIRAFDRDKPNT-PNSDVHYSIVSGNDDGHFALESSHKPVL---L 183
T L P+ + + + + D + + Y + + A + P L
Sbjct: 487 TYSLLPPQDPHLPLSSLVSINADNGHLFALRSLDYEALQAFEFRVGAADRG-SPALSSEA 545
Query: 184 LRKVLDYDAGDKE-FQLVIMASGKRIHKEIL--FPEP------IHAIDQDLGVGATLRYE 234
L +VL DA D F L + +G E++ EP + A+D D G A L Y+
Sbjct: 546 LVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDSDSGQNAWLSYQ 605
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
L+ + LF + + NG + + L +E + + V+ V+ + P ++A A + +
Sbjct: 606 LLKATEPGLFGVWAHNGEV---RTARLLSERDAAKHRLVVLVKDN--GEPPRSATATLHV 660
Query: 295 ELLD 298
L+D
Sbjct: 661 LLVD 664
>AK127704-1|BAC87093.1| 1366|Homo sapiens protein ( Homo sapiens
cDNA FLJ45804 fis, clone NT2RI3005923, weakly similar
to Cadherin-related tumor suppressor precursor. ).
Length = 1366
Score = 111 bits (268), Expect = 1e-23
Identities = 130/503 (25%), Positives = 220/503 (43%), Gaps = 61/503 (12%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
++VE+ +LD NDN PVF Y +++ +A+ G + +V+A D DLG NG V Y ++
Sbjct: 280 LSVELRVLDENDNPPVFEQDE-YRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRAR 338
Query: 503 S---------NLTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYS 551
L + F + +G V V E + H L VEA D A P
Sbjct: 339 QVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVR 398
Query: 552 LAVVTIEVTRGTKGNKPDIPD-FMGAPYEFWVGSNVGIGTSVGQIRVNDA---FEQND-V 606
+++ ++V N+P I F+ V G V ++ V+DA +E+ D
Sbjct: 399 VSIAVLDVN----DNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEA 454
Query: 607 SYDLLHGYEEG-VPFAVEERSG-------------VITVVDDLSRYNRPMYDFEAVALQE 652
+ +L G +G + ++E G + V L R +R +Y+ VA
Sbjct: 455 TGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDA 514
Query: 653 NAN-LSIVTNATVHVVDVNDE----------RGVLLKGAHSPIIFHVKENSA---GAAIG 698
+ LS + V D+ND+ V A ++ V + A G+
Sbjct: 515 GSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHA 574
Query: 699 QIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVI 757
+ +T + G++ + + + AI +E G I T + LDRE ++ + V+
Sbjct: 575 WLRYTVVQLSAPCNLGSLESKMVHTAECGPSFAIDSESGVISTIRALDREVQEAVELKVV 634
Query: 758 AEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDA 817
A+ + G + V+I ++D NDN P+F Y I E++ +G + A+DA
Sbjct: 635 AQ-DLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQ---VTASDA 690
Query: 818 DEGTNALFMYTLFG-----EGKEMFDVDENTGVVKFIGDSLDREKK-IMYKLSLVARDTG 871
D G Y+L+ E + F +D + G + + +DRE+ Y L + A+D G
Sbjct: 691 DSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQI-CVSQDIDRERDPATYDLLVEAKDGG 749
Query: 872 GLSSEAELIIMIGDENDNKPEFN 894
GLS++A + + + D NDN P FN
Sbjct: 750 GLSAQAFVRVDLEDVNDNHPVFN 772
Score = 84.2 bits (199), Expect = 3e-15
Identities = 110/455 (24%), Positives = 181/455 (39%), Gaps = 26/455 (5%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V L D NDN+PVF PS Y S+ + GT I V A D D G G V Y+L +
Sbjct: 757 VRVDLEDVNDNHPVFNPST-YVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGN- 814
Query: 505 LTITSPFKINPNTGTVSVAESPI--LEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
++S F I+ TG + + P+ LE L + ++ + AV+ +VT
Sbjct: 815 --VSSLFTIDSTTGIIYLT-LPLSHLESTTLLLMVSAQDGGGLT------AVINADVTIH 865
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAV 622
+F Y F V +V + +G ++ + ++ + + + G F++
Sbjct: 866 IFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSI 925
Query: 623 EERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHS 682
R G I L +P+ A +A T + V+DVND L+ S
Sbjct: 926 HPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLR--TS 983
Query: 683 PIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQK 742
I + G A ++ G +R+ IA+ Q I A G +F
Sbjct: 984 DEIRISQTTPPGTA---LYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRAL-GVLFLNG 1039
Query: 743 PLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP-VFEHATYEGFIMENSK 801
L ++ +T+ AE ++GV A + +T+ IE +P FEH Y+ + E+
Sbjct: 1040 SLGAGEQRELTLTLRAE-DQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLS 1098
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMY 861
T++ + + L MF + TG + ++ D E Y
Sbjct: 1099 PMTQM-LQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWI-YLRRQFDYESTQTY 1156
Query: 862 KLSLVA--RDTGGLSS-EAELIIMIGDENDNKPEF 893
+ A + G L + +I+ + DENDN P F
Sbjct: 1157 NFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTF 1191
Score = 77.0 bits (181), Expect = 5e-13
Identities = 73/269 (27%), Positives = 121/269 (44%), Gaps = 11/269 (4%)
Query: 610 LLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQ-ENANLSIVTNATVHVVD 668
++H E G FA++ SGVI+ + L R + + + VA LS ++ V D
Sbjct: 596 MVHTAECGPSFAIDSESGVISTIRALDREVQEAVELKVVAQDLGEPPLSATCLVSITVDD 655
Query: 669 VNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSS-IYGNGTGNVRFLIANQQDVT 727
VND + + ++ I + G Q+ ++ S +YG ++ + +
Sbjct: 656 VNDNEPIFWRQVYNATI--AEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQ 713
Query: 728 DDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVF 787
DG I + +DRE RD ++ E G A + V + +ED NDN PVF
Sbjct: 714 AFRIDPHDGQICVSQDIDRE-RDPATYDLLVEAKDGGGLSAQAF-VRVDLEDVNDNHPVF 771
Query: 788 EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTGVV 846
+TY I + ++ GTEI N++ ATD D G Y L G +F +D TG++
Sbjct: 772 NPSTYVTSISDETQPGTEI--INVL-ATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGII 828
Query: 847 KFIGDSLDREKKIMYKLSLVARDTGGLSS 875
++ L + L + A+D GGL++
Sbjct: 829 -YLTLPLSHLESTTLLLMVSAQDGGGLTA 856
Score = 76.6 bits (180), Expect = 6e-13
Identities = 92/355 (25%), Positives = 144/355 (40%), Gaps = 23/355 (6%)
Query: 44 VDSDSPQNVVKFRLGCDFDEGDDLVRIGAGLNQ--ISAYLSVTVYIEDVNDNVPIFLDTP 101
+DS+S L + E +L + L + +SA V++ ++DVNDN PIF
Sbjct: 608 IDSESGVISTIRALDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQV 667
Query: 102 YHVTVDELTPTGEKAFIFLIAPIGPSLT---IPLTVPRGLTIFKDIRAFDRDKPNTPNSD 158
Y+ T+ E P G F+ + A S I ++ G ++ +AF D P+
Sbjct: 668 YNATIAEHAPVGH-CFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRID-PHDGQIC 725
Query: 159 VHYSIVSGNDDGHFAL--ESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPE 216
V I D + L E+ L + + D D + + +
Sbjct: 726 VSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQ 785
Query: 217 P------IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQAN 270
P + A DQD G+ T+ YELI GN LF++DS G ++L L +L++
Sbjct: 786 PGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLS-----HLEST 840
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
T +L V A A V I + EFE Y + E++P + V A
Sbjct: 841 TLLLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKA 900
Query: 331 TDK-DQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAK 384
+ + E + D G FSI PR G T+R + LD E + + V A+
Sbjct: 901 REPLNSSEPIFYRISSGDLGGKFSIHPRLG--TIRTRKPLDHETQPVVVLTVQAQ 953
Score = 76.2 bits (179), Expect = 9e-13
Identities = 54/190 (28%), Positives = 86/190 (45%), Gaps = 12/190 (6%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I E+ P+G +++ A D DSGL G I Y + E + F I+ G
Sbjct: 672 IAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFL---------SYEAPQAFRIDPHDG 722
Query: 1000 HVIVARSLPPESE---FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEE 1056
+ V++ + E + + L + A DGG L+ VRV ++DVND+ PVF + Y ++ +
Sbjct: 723 QICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISD 782
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKY 1116
+ V ATD D G + Y + P + F I TG++ + L
Sbjct: 783 ETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTL 842
Query: 1117 ILTVVARDNG 1126
+L V A+D G
Sbjct: 843 LLMVSAQDGG 852
Score = 71.3 bits (167), Expect = 2e-11
Identities = 55/164 (33%), Positives = 84/164 (51%), Gaps = 22/164 (13%)
Query: 744 LDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIG 803
LDRE+ +R+ + A ++ G G+ V + + DENDNPPVFE Y + E+++ G
Sbjct: 254 LDREEAAAHRLQIEA-WDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPG 312
Query: 804 TEIKMDNIIKATDADEGTNALFMYTL-------FGEG------KEMFDVDENTGVVKFIG 850
E+ ++ATD D G N Y++ G G F V+E +GVV+ +
Sbjct: 313 AEVCR---VRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVR-VW 368
Query: 851 DSLDREKKIMYKLSLVARDTGGLSSEAELI---IMIGDENDNKP 891
LDRE + ++L + ARD GG E + I + D NDN+P
Sbjct: 369 RPLDREAQAWHQLVVEARD-GGAEPEVATVRVSIAVLDVNDNRP 411
Score = 68.1 bits (159), Expect = 2e-10
Identities = 95/398 (23%), Positives = 162/398 (40%), Gaps = 30/398 (7%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL- 499
S V +T++D NDN+P F+ ++ E + GT + +A D D G+NG++ Y +
Sbjct: 961 SSTEVNITVMDVNDNHPAFLRTS-DEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIA 1019
Query: 500 -QRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIE 558
+ I + G++ E L L + A DQ +P + +L V+T+
Sbjct: 1020 SPQPGVFAIDRALGVLFLNGSLGAGEQREL----TLTLRAEDQGVHP---QAALLVLTVV 1072
Query: 559 VTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGV 618
+ + + + P F Y+ V ++ T + Q + + Q S L + E V
Sbjct: 1073 IEK--REHSPSW-TFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS-PLRYSLEPSV 1128
Query: 619 P---FAVEERSGVITVVDDLSRYNRPMYDFEAVA-LQENANL-SIVTNATVHVVDVNDER 673
F + +G I + + Y+F A + E+ L ++ T V V D ND
Sbjct: 1129 DSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNS 1188
Query: 674 GVLLKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI 732
L H + V+E+ IG+I +M S G + FL+++ + +
Sbjct: 1189 PTFL---HDVLFLKVEESPVPQGVIGKITAIDMDS--GKNGQLLYFLLSDGKFFKMN--- 1240
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
G + LDRE R + MTV+ ++G V + + D NDN P F
Sbjct: 1241 PNTGELINWVALDREHRGHHEMTVLVT-DRGSPPRNATMAVYVSVTDINDNRPFFPQCLP 1299
Query: 793 EGFIMENSKIGTEIKM-DNIIKATDADEGTNALFMYTL 829
+ G + M + A D DEG NA Y++
Sbjct: 1300 GKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
Score = 64.1 bits (149), Expect = 4e-09
Identities = 47/135 (34%), Positives = 65/135 (48%), Gaps = 13/135 (9%)
Query: 244 FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNL 303
F++DS +G + + LD + + ++ L+V A L P +A V I + D+NDN
Sbjct: 606 FAIDSESGVISTIRALDREVQEAVE-----LKVVAQDLGEPPLSATCLVSITVDDVNDNE 660
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD------PKGAFSIDPR 357
P F YN +I E+ P G LQV A+D D G G Y L D AF IDP
Sbjct: 661 PIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPH 720
Query: 358 SGWLTVRNQTVLDRE 372
G + V +DRE
Sbjct: 721 DGQICVSQD--IDRE 733
Score = 64.1 bits (149), Expect = 4e-09
Identities = 104/471 (22%), Positives = 189/471 (40%), Gaps = 42/471 (8%)
Query: 439 LMSFVNVEVTL-LDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
L + +N +VT+ + P Y F + + + IG VKA +P L + + Y
Sbjct: 854 LTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIFY 912
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTI 557
R S+ + F I+P GT+ + E + + + Q + A +
Sbjct: 913 ---RISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAP------ACSST 963
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE-QNDVSYDLLHGYEE 616
EV + P F+ E + GT++ R D +N + + +
Sbjct: 964 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQP 1023
Query: 617 GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVL 676
GV FA++ GV+ + L + E + + A + V+ V V+
Sbjct: 1024 GV-FAIDRALGVLFLNGSLGAGEQR----ELTLTLRAEDQGVHPQAALLVLTV-----VI 1073
Query: 677 LKGAHSP------IIFHVKENSAGAAIGQIFHTNMSSIYGNGTGN-VRFLIANQQDVTDD 729
K HSP +++ V+ + + + + Q+ T + + +R+ + D
Sbjct: 1074 EKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMF 1133
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNK-GVISGAGIYQVTIYIEDENDNPPVFE 788
G I+ ++ D E Y V A + G + V + + DENDN P F
Sbjct: 1134 GIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST-TVIVRVWDENDNSPTFL 1192
Query: 789 HATYEGFI-MENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTG-VV 846
H F+ +E S + + I A D D G N +Y L +GK F ++ NTG ++
Sbjct: 1193 HDVL--FLKVEESPVPQGVI--GKITAIDMDSGKNGQLLYFLLSDGK-FFKMNPNTGELI 1247
Query: 847 KFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIG--DENDNKPEFNQ 895
++ +LDRE + ++++++ D G A + + + D NDN+P F Q
Sbjct: 1248 NWV--ALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQ 1296
Score = 64.1 bits (149), Expect = 4e-09
Identities = 46/131 (35%), Positives = 62/131 (47%), Gaps = 3/131 (2%)
Query: 1021 DGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANL 1080
DG N + +V V V D ND+ P F VEE+ + V+GK+ A D D G+N L
Sbjct: 1167 DGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQL 1226
Query: 1081 TYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXX 1140
YF+ SD F+++P TG L LDRE + +TV+ D G
Sbjct: 1227 LYFLL-SDGKF-FKMNPNTGELINWVALDREHRGHHEMTVLVTDRG-SPPRNATMAVYVS 1283
Query: 1141 XXDVNDNSPKF 1151
D+NDN P F
Sbjct: 1284 VTDINDNRPFF 1294
Score = 62.9 bits (146), Expect = 9e-09
Identities = 96/369 (26%), Positives = 147/369 (39%), Gaps = 58/369 (15%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ E+ G + ++ A D D G NG +RY + +P + AL YF + E G
Sbjct: 305 VREDAQPGAEVCRVRATDRDLGPNGFVRYSVRAR-QVPGAGSGGGALGDAAYFAVEELSG 363
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVK--DVNDHFPVFKKTWYN---- 1051
V V R L E++ +L + A DGG + +VRV + DVND+ P +
Sbjct: 364 VVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGV 423
Query: 1052 FNVEEAQYTRRVLGKVDATDAD---------FGQ------NANLTYFIQPSDTDLPFEIS 1096
V E + +V +DAD G+ + +++ ++ + D
Sbjct: 424 ARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPG 483
Query: 1097 PLTGV--LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAF 1154
GV L V G LDRE+ D Y L +VA D G D+ND P
Sbjct: 484 GPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVA-DLNDQPP----- 537
Query: 1155 DELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLI 1214
L +H YKA++ E A GT V V A+D D G+ + +
Sbjct: 538 --LFSQQH-------------------YKASVSEAAAPGTVVMWVSASDADEAGSDHAWL 576
Query: 1215 LYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPV 1274
Y++ Q NLG SL S MV A+ + + IS L+ E +
Sbjct: 577 RYTVVQLSAPCNLG--SLESK---MVHTAECGPSFAIDSESGVISTIRALDREVQEAVEL 631
Query: 1275 ELVSLNLTE 1283
++V+ +L E
Sbjct: 632 KVVAQDLGE 640
Score = 62.9 bits (146), Expect = 9e-09
Identities = 80/324 (24%), Positives = 130/324 (40%), Gaps = 24/324 (7%)
Query: 77 ISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSL-------T 129
+SA V V +EDVNDN P+F + Y ++ + T G + L +
Sbjct: 751 LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYEL 810
Query: 130 IPLTVPRGLTIFKDIRAFDRDKPNTP-NSDVHYSIVSGNDDGHF-ALESSHKPVLLLRKV 187
IP V TI P + S +VS D G A+ ++ + + +
Sbjct: 811 IPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLLLMVSAQDGGGLTAVINADVTIHIFQTT 870
Query: 188 LDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAID--QDLGVGATLRYELISGNDRKLFS 245
L EF+ +++++ PI + + L + Y + SG+ FS
Sbjct: 871 L----APAEFERPKYTF--LVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFS 924
Query: 246 LDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPE 305
+ G++ K LD H Q VL VQA QL + + V I ++D+NDN P
Sbjct: 925 IHPRLGTIRTRKPLD----HETQP-VVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPA 978
Query: 306 FEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK-GAFSIDPRSGWLTVR 364
F I I + P G ++ A D+D G NG Y + P+ G F+ID G L +
Sbjct: 979 FLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLN 1038
Query: 365 NQTVLDREAHSSLRMKVYAKETNP 388
+ +L ++ + +P
Sbjct: 1039 GSLGAGEQRELTLTLRAEDQGVHP 1062
Score = 60.9 bits (141), Expect = 3e-08
Identities = 120/502 (23%), Positives = 194/502 (38%), Gaps = 53/502 (10%)
Query: 443 VNVEVTLL----DANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG--QNGMVL 496
++ E TLL D ND P+F + Y+ S+ A GTV+ V A D D + +
Sbjct: 519 LSTEETLLLRVADLNDQPPLFSQQH-YKASVSEAAAPGTVVMWVSASDADEAGSDHAWLR 577
Query: 497 YDLQRTS---NL-TITSP----------FKINPNTGTVSVAESPILEGRHALFVEASDQP 542
Y + + S NL ++ S F I+ +G +S + E + A+ ++ Q
Sbjct: 578 YTVVQLSAPCNLGSLESKMVHTAECGPSFAIDSESGVISTIRALDREVQEAVELKVVAQD 637
Query: 543 -ANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAF 601
P L +T++ + P F Y + + +G Q+ +DA
Sbjct: 638 LGEPPLSATCLVSITVDDVNDNE------PIFWRQVYNATIAEHAPVGHCFLQVTASDAD 691
Query: 602 E--QNDVSYDLLHG---YEEGVPFAVEERSGVITVVDDLSRYNRPM-YDFEAVALQENAN 655
+ Y L G YE F ++ G I V D+ R P YD V ++
Sbjct: 692 SGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDL-LVEAKDGGG 750
Query: 656 LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNM-SSIYGNGTG 714
LS V + DVND V + I E G I + T+ S IY GT
Sbjct: 751 LSAQAFVRVDLEDVNDNHPVFNPSTYVTSI--SDETQPGTEIINVLATDQDSGIY--GTV 806
Query: 715 NVRFLIANQQDV-TDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQV 773
+ N + T D + G I+ PL + + V A+ G+ + V
Sbjct: 807 AYELIPGNVSSLFTID---STTGIIYLTLPLSHLESTTLLLMVSAQDGGGLTAVINA-DV 862
Query: 774 TIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG 833
TI+I P FE Y + E+ + I +KA + + +F G+
Sbjct: 863 TIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPI---GTVKAREPLNSSEPIFYRISSGDL 919
Query: 834 KEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVAR-DTGGLSSEAELIIMIGDENDNKPE 892
F + G ++ LD E + + L++ A+ + S E+ I + D NDN P
Sbjct: 920 GGKFSIHPRLGTIR-TRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPA 978
Query: 893 FNQIEENSKVRIHRETKLNGTA 914
F + + ++RI + T GTA
Sbjct: 979 F--LRTSDEIRISQTTP-PGTA 997
Score = 60.5 bits (140), Expect = 5e-08
Identities = 86/362 (23%), Positives = 144/362 (39%), Gaps = 31/362 (8%)
Query: 992 FVINERHGHVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKK 1047
F I+ G + R+L E + L + A D G L+ V + V DVND+ P+F +
Sbjct: 606 FAIDSESGVISTIRALDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWR 665
Query: 1048 TWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS----DTDLPFEISPLTGVLS 1103
YN + E +V A+DAD G + Y + + F I P G +
Sbjct: 666 QVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQIC 725
Query: 1104 VNGELDRETED-KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKH 1162
V+ ++DRE + Y L V A+D G DVNDN P F
Sbjct: 726 VSQDIDRERDPATYDLLVEAKDGG---GLSAQAFVRVDLEDVNDNHPVFN--------PS 774
Query: 1163 PEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTD---FIGNGNGLILYSLP 1219
+S+ +I V AT +++ GT ++ + I + G+I +LP
Sbjct: 775 TYVTSISDETQPGTEIINVL-ATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLP 833
Query: 1220 QRKNQQNLGLPSLSST---AILMVTVADVPDEV-EMSDKPVFISR-YYELEIEENVNAPV 1274
+ L +S+ + V ADV + + + P R Y + E+V
Sbjct: 834 LSHLESTTLLLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDS 893
Query: 1275 ELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVR 1334
+ ++ E + + +Y ++ D+ F I PR GT+ + D E + + V+
Sbjct: 894 PIGTVKAREPLNSSEPIFYRISSG--DLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQ 951
Query: 1335 AE 1336
A+
Sbjct: 952 AQ 953
Score = 56.8 bits (131), Expect = 6e-07
Identities = 29/72 (40%), Positives = 40/72 (55%)
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
LQ++A P +T VE+ +LD NDN P FE D Y ++ E+ G V +V ATD+
Sbjct: 264 LQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDR 323
Query: 334 DQGENGEFTYQL 345
D G NG Y +
Sbjct: 324 DLGPNGFVRYSV 335
Score = 56.4 bits (130), Expect = 7e-07
Identities = 44/152 (28%), Positives = 65/152 (42%), Gaps = 8/152 (5%)
Query: 231 LRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQA 290
LRY L D +F + G ++L ++ D ++ F + L N T
Sbjct: 1120 LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIV 1179
Query: 291 RVEIELLDLNDNLPEFEVDFYNISIVEN-LPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
RV D NDN P F D + + E+ +P G + ++ A D D G+NG+ Y L
Sbjct: 1180 RV----WDENDNSPTFLHDVLFLKVEESPVPQGV-IGKITAIDMDSGKNGQLLYFLLSDG 1234
Query: 350 GAFSIDPRSGWLTVRNQTVLDREAHSSLRMKV 381
F ++P +G L N LDRE M V
Sbjct: 1235 KFFKMNPNTGELI--NWVALDREHRGHHEMTV 1264
Score = 56.0 bits (129), Expect = 1e-06
Identities = 48/153 (31%), Positives = 64/153 (41%), Gaps = 15/153 (9%)
Query: 1014 RLNISALDGGNLNDN--ISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATD 1071
RL I A DGG +SV + V D ND+ PVF++ Y V E + +V ATD
Sbjct: 263 RLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATD 322
Query: 1072 ADFGQNANLTYFIQPSDTD------------LPFEISPLTGVLSVNGELDRETEDKYILT 1119
D G N + Y ++ F + L+GV+ V LDRE + + L
Sbjct: 323 RDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLV 382
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY 1152
V ARD G DVNDN P +
Sbjct: 383 VEARDGG-AEPEVATVRVSIAVLDVNDNRPAIH 414
Score = 54.8 bits (126), Expect = 2e-06
Identities = 42/136 (30%), Positives = 59/136 (43%), Gaps = 11/136 (8%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I AID D G L Y L+S D K F ++ G L + LD EH VL
Sbjct: 1213 ITAIDMDSGKNGQLLYFLLS--DGKFFKMNPNTGELI--NWVALDREHRGHHEMTVL--- 1265
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDF----YNISIVENLPNGFSVLQVMATDK 333
+ +P + A V + + D+NDN P F ++ ++E P V V A D
Sbjct: 1266 VTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDP 1325
Query: 334 DQGENGEFTYQLDDPK 349
D+G N E TY + +
Sbjct: 1326 DEGNNAEVTYSVSSAR 1341
Score = 51.2 bits (117), Expect = 3e-05
Identities = 51/186 (27%), Positives = 82/186 (44%), Gaps = 25/186 (13%)
Query: 937 LFLIPENIPIGTTII-KLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVIN 995
LFL E P+ +I K+ A+D+DSG NGQ+ Y S+ ++F +N
Sbjct: 1196 LFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD---------------GKFFKMN 1240
Query: 996 ERHGHVI--VARSLPPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTW-- 1049
G +I VA + + D G+ N ++V V V D+ND+ P F +
Sbjct: 1241 PNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPG 1300
Query: 1050 --YNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGE 1107
+ V E Q ++ V A D D G NA +TY + S +P + G S +
Sbjct: 1301 KELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVS-SARHMPLKGKTAFGKQSCKKQ 1359
Query: 1108 LDRETE 1113
+++T+
Sbjct: 1360 TNKQTK 1365
Score = 47.2 bits (107), Expect = 5e-04
Identities = 39/138 (28%), Positives = 58/138 (42%), Gaps = 4/138 (2%)
Query: 992 FVINERHGHVIVARSLPPESE--FRLNISA-LDGGNLNDNISVRVFVKDVNDHFPVFKKT 1048
F I+ R G + + L E++ L + A L + V + V DVND+ P F +T
Sbjct: 923 FSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRT 982
Query: 1049 WYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGEL 1108
+ + L A D D G+N + Y I + F I GVL +NG L
Sbjct: 983 SDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGV-FAIDRALGVLFLNGSL 1041
Query: 1109 DRETEDKYILTVVARDNG 1126
+ + LT+ A D G
Sbjct: 1042 GAGEQRELTLTLRAEDQG 1059
Score = 45.2 bits (102), Expect = 0.002
Identities = 50/183 (27%), Positives = 80/183 (43%), Gaps = 27/183 (14%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY--E 793
G + +PLDRE + +++ V A + G +V+I + D NDN P H + E
Sbjct: 363 GVVRVWRPLDREAQAWHQLVVEAR-DGGAEPEVATVRVSIAVLDVNDNRPAI-HVLFLTE 420
Query: 794 GFIM---ENSKIGTEIKMDNIIKATD----ADEGTNALFMYTLFGEGKEMFDVDENTGVV 846
G + E ++ G + ++ A DE T L + G+G ++ G
Sbjct: 421 GGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVG--LGDGSISLSLEGGEGDF 478
Query: 847 KFIGDS------------LDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
+ LDRE + +Y+L LVA D G LS+E L++ + D ND P
Sbjct: 479 ALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPL 538
Query: 893 FNQ 895
F+Q
Sbjct: 539 FSQ 541
Score = 44.8 bits (101), Expect = 0.002
Identities = 82/324 (25%), Positives = 120/324 (37%), Gaps = 36/324 (11%)
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEEN 899
D G VK + L+ + I Y++S +G L + + +G KP + E
Sbjct: 892 DSPIGTVK-AREPLNSSEPIFYRIS-----SGDLGGKFSIHPRLGTIRTRKPLDH--ETQ 943
Query: 900 SKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFL-------IPENIPIGTTIIK 952
V + + +L + EV N +DV+ P FL I + P GT +
Sbjct: 944 PVVVLTVQAQLGSAPACSSTEV---NITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYL 1000
Query: 953 LNALDLDSGLNGQIRYEFNSEVYIPPSKLSAD-ALEVKRYFVINERHGHVIVARSLPPES 1011
A D DSG NG IRY S P + D AL V +N G +
Sbjct: 1001 ARAEDRDSGRNGLIRYSIASP---QPGVFAIDRALGV---LFLNGSLG-------AGEQR 1047
Query: 1012 EFRLNISALDGG-NLNDNISVRVFVKDVNDHFP--VFKKTWYNFNVEEAQYTRRVLGKVD 1068
E L + A D G + + V V + +H P F+ Y V E+ + +
Sbjct: 1048 ELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQ 1107
Query: 1069 ATDADFGQNAN-LTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGX 1127
A + A+ L Y ++PS F I P TG + + + D E+ Y V A
Sbjct: 1108 AHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPED 1167
Query: 1128 XXXXXXXXXXXXXXXDVNDNSPKF 1151
D NDNSP F
Sbjct: 1168 GFLQNVSTTVIVRVWDENDNSPTF 1191
Score = 40.3 bits (90), Expect = 0.052
Identities = 39/119 (32%), Positives = 55/119 (46%), Gaps = 13/119 (10%)
Query: 714 GNVRFLIANQQD--VTDDIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGI 770
G+ FL + D + DD + D G I T + LDRE+RD Y F + GA +
Sbjct: 98 GSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHY------SFVAATLLGA-V 150
Query: 771 YQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL 829
QV I + D ND+ P F + + + E S GT ++ A D D G + YTL
Sbjct: 151 VQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPG---AHDPDAGLFSTQGYTL 206
Score = 35.9 bits (79), Expect = 1.1
Identities = 25/85 (29%), Positives = 39/85 (45%), Gaps = 3/85 (3%)
Query: 251 GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDF 310
G FL E LD E + + L + A+ +P + + + + + DLND P F
Sbjct: 487 GVFFLCVEGPLDRESR---DLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQH 543
Query: 311 YNISIVENLPNGFSVLQVMATDKDQ 335
Y S+ E G V+ V A+D D+
Sbjct: 544 YKASVSEAAAPGTVVMWVSASDADE 568
Score = 34.3 bits (75), Expect = 3.4
Identities = 24/80 (30%), Positives = 35/80 (43%), Gaps = 1/80 (1%)
Query: 288 AQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD 347
A +VEI + D+ND+ P F +D + + E P G + A D D G Y L
Sbjct: 149 AVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPGAHDPDAGLFSTQGYTLVQ 208
Query: 348 PKGAFSIDPRSGWLTVRNQT 367
P DP + +R +T
Sbjct: 209 PSD-LPKDPAGPFFQLRYRT 227
Score = 33.5 bits (73), Expect = 6.0
Identities = 19/66 (28%), Positives = 29/66 (43%), Gaps = 3/66 (4%)
Query: 445 VEVTLLDANDNNPVF---VPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQR 501
V V++ D NDN P F +P + V ++ V A DPD G N V Y +
Sbjct: 1280 VYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
Query: 502 TSNLTI 507
++ +
Sbjct: 1340 ARHMPL 1345
Score = 33.1 bits (72), Expect = 7.9
Identities = 21/54 (38%), Positives = 29/54 (53%), Gaps = 4/54 (7%)
Query: 853 LDREKKIMYKLSLVARDTGGLSSEAELI---IMIGDENDNKPEFNQIEENSKVR 903
LDRE+ ++L + A D GG L+ + + DENDN P F Q E + VR
Sbjct: 254 LDREEAAAHRLQIEAWD-GGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVR 306
Score = 33.1 bits (72), Expect = 7.9
Identities = 32/117 (27%), Positives = 52/117 (44%), Gaps = 17/117 (14%)
Query: 218 IHAIDQDLGVGATLRYEL----ISG--------NDRKLFSLDSVNGSLFLEKELDLDAEH 265
+ A D+DLG +RY + + G D F+++ ++G + + + LD +A+
Sbjct: 318 VRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQA 377
Query: 266 NLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNG 322
Q L V+A + A RV I +LD+NDN P V F V + G
Sbjct: 378 WHQ-----LVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEG 429
>AF217755-1|AAK51622.1| 796|Homo sapiens protocadherin-beta3
protein.
Length = 796
Score = 111 bits (268), Expect = 1e-23
Identities = 122/467 (26%), Positives = 203/467 (43%), Gaps = 36/467 (7%)
Query: 440 MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
+ FV E+ ++D ND++PVF + ++ ++S GTVI A D D+G+N + Y +
Sbjct: 114 LQFVTNELRIIDVNDHSPVFFENEMHLKILESTLP-GTVIPLGNAEDLDVGRNSLQNYTI 172
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLAVVT 556
S+ + + + + V + + + +L + A D + P R A +
Sbjct: 173 TPNSHFHVLTRSRRDGRKYPELVLDKALDREEQPELSLTLTALDGGSPP---RSGTAQIN 229
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN--DAFEQNDVSYDLLHGY 614
I+V + P+F YE V N + + + + + D +SY H
Sbjct: 230 IQVL----DINDNAPEFAQPLYEVAVLENTPVNSVIVTVSASDLDTGSFGTISYAFFHAS 285
Query: 615 EE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDER 673
EE F + +G + +V L+ Y+ + + ++ LS + V VVDVND
Sbjct: 286 EEIRKTFQLNPITGDMQLVKYLNFEAINSYEVD-IEAKDGGGLSGKSTVIVQVVDVNDNP 344
Query: 674 GVL-LKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI 732
L L +SPI ENS G + +F ++S + G V I N ++
Sbjct: 345 PELTLSSVNSPI----PENS-GETVLAVF--SVSDLDSGDNGRVMCSIENNLPFFLKPSV 397
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
T+ ++ LDRE R Y +T+ + G Y +T+ + D NDN P F +Y
Sbjct: 398 ENFYTLVSEGALDRETRSEYNITITIT-DLGTPRLKTKYNITVLVSDVNDNAPAFTQISY 456
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDENTGVV 846
F+ EN+ I + ATD D GTNA Y+L + ++ + G +
Sbjct: 457 TLFVRENNSPALHI---GSVSATDRDSGTNAQVTYSLLPPQDPHLPLSSLVSINADNGHL 513
Query: 847 KFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
F SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 514 -FALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDNSP 559
Score = 80.6 bits (190), Expect = 4e-14
Identities = 58/222 (26%), Positives = 106/222 (47%), Gaps = 9/222 (4%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
K LDRE++ +T+ A + G +G Q+ I + D NDN P F YE ++EN+
Sbjct: 198 KALDREEQPELSLTLTA-LDGGSPPRSGTAQINIQVLDINDNAPEFAQPLYEVAVLENTP 256
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM---FDVDENTGVVKFIGDSLDREKK 858
+ + I + A+D D G+ Y F +E+ F ++ TG ++ + L+ E
Sbjct: 257 VNSVIVT---VSASDLDTGSFGTISYAFFHASEEIRKTFQLNPITGDMQLV-KYLNFEAI 312
Query: 859 IMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTI 918
Y++ + A+D GGLS ++ +I+ + D NDN PE NS + + + +
Sbjct: 313 NSYEVDIEAKDGGGLSGKSTVIVQVVDVNDNPPELTLSSVNSPIPENSGETVLAVFSVSD 372
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDS 960
++ + ++ P FL P ++ T++ ALD ++
Sbjct: 373 LDSGDNGRVMCSIENNLPFFLKP-SVENFYTLVSEGALDRET 413
Score = 77.4 bits (182), Expect = 4e-13
Identities = 121/502 (24%), Positives = 205/502 (40%), Gaps = 76/502 (15%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEF--NSEVYIPPSKLSADALEVKRYFVI 994
L ++ +P GT I NA DLD G N Y NS ++ L+ + ++Y
Sbjct: 140 LKILESTLP-GTVIPLGNAEDLDVGRNSLQNYTITPNSHFHV----LTRSRRDGRKY--- 191
Query: 995 NERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWY 1050
+++ ++L E E L ++ALDGG+ + + + V D+ND+ P F + Y
Sbjct: 192 ----PELVLDKALDREEQPELSLTLTALDGGSPPRSGTAQINIQVLDINDNAPEFAQPLY 247
Query: 1051 NFNVEEAQYTRRVLGKVDATDADFGQNANLTY--FIQPSDTDLPFEISPLTGVLSVNGEL 1108
V E V+ V A+D D G ++Y F + F+++P+TG + + L
Sbjct: 248 EVAVLENTPVNSVIVTVSASDLDTGSFGTISYAFFHASEEIRKTFQLNPITGDMQLVKYL 307
Query: 1109 DRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADEL 1168
+ E + Y + + A+D G DVNDN P+ L P +
Sbjct: 308 NFEAINSYEVDIEAKDGG---GLSGKSTVIVQVVDVNDNPPEL----TLSSVNSP----I 356
Query: 1169 SNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDF----IGNGNGLILYSLPQRKNQ 1224
++ E+V + V+ + ++ G + + N F + N L+ R+ +
Sbjct: 357 PENSGETV--LAVFSVSDLDSGDNGRVMCSIENNLPFFLKPSVENFYTLVSEGALDRETR 414
Query: 1225 Q---------NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVE 1275
+LG P L + + V V+DV D + P F Y L + EN + +
Sbjct: 415 SEYNITITITDLGTPRLKTKYNITVLVSDVND-----NAPAFTQISYTLFVRENNSPALH 469
Query: 1276 LVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREVKDTYEV 1331
+ S++ T+ N ++ Y +L D + + + I+ NG L+ +RS D E +E
Sbjct: 470 IGSVSATDRDSGTNAQVTYSLLPPQDPHLPLSSLVSINADNGHLFALRSLDYEALQAFEF 529
Query: 1332 IVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTNGNRPL 1387
V A R P + + V V + D NDNSP NG+ P
Sbjct: 530 RVGAT----DRGSPAL-------------SSEALVRVLVLDANDNSPFVLYPLQNGSAPC 572
Query: 1388 VTAIPTTAPFGYQVMQLKGAIG 1409
+P A GY V ++ G
Sbjct: 573 TELVPRAAEPGYLVTKVVAVDG 594
Score = 76.2 bits (179), Expect = 9e-13
Identities = 69/235 (29%), Positives = 103/235 (43%), Gaps = 28/235 (11%)
Query: 929 LDVDQLGPLFLIP-------ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD++ P F P EN P+ + I+ ++A DLD+G G I Y F
Sbjct: 233 LDINDNAPEFAQPLYEVAVLENTPVNSVIVTVSASDLDTGSFGTISYAFFHA-------- 284
Query: 982 SADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGNLNDNISVRVFVKDVN 1039
+ E+++ F +N G + + + L E+ + ++I A DGG L+ +V V V DVN
Sbjct: 285 ---SEEIRKTFQLNPITGDMQLVKYLNFEAINSYEVDIEAKDGGGLSGKSTVIVQVVDVN 341
Query: 1040 DHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLT 1099
D+ P + N + E VL +D D G N + I + +LPF + P
Sbjct: 342 DNPPELTLSSVNSPIPE-NSGETVLAVFSVSDLDSGDNGRVMCSI---ENNLPFFLKPSV 397
Query: 1100 G---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
L G LDRET +Y +T+ D G DVNDN+P F
Sbjct: 398 ENFYTLVSEGALDRETRSEYNITITITDLG-TPRLKTKYNITVLVSDVNDNAPAF 451
Score = 71.3 bits (167), Expect = 2e-11
Identities = 106/457 (23%), Positives = 188/457 (41%), Gaps = 36/457 (7%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
+ + +LD NDN P F LYE ++ N V +VI V A D D G G + Y S
Sbjct: 228 INIQVLDINDNAPEFAQP-LYEVAVLENTPVNSVIVTVSASDLDTGSFGTISYAFFHASE 286
Query: 505 LTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRGTK 564
I F++NP TG + + + E ++ V+ + + ++ V ++V
Sbjct: 287 -EIRKTFQLNPITGDMQLVKYLNFEAINSYEVDIEAKDGGGLSGKSTVIVQVVDV----N 341
Query: 565 GNKPDIP-DFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVE 623
N P++ + +P + N G T + V+D + D + ++ E +PF ++
Sbjct: 342 DNPPELTLSSVNSP----IPENSG-ETVLAVFSVSD-LDSGD-NGRVMCSIENNLPFFLK 394
Query: 624 ER-SGVITVVDD--LSRYNRPMYDFE-AVALQENANLSIVTNATVHVVDVNDERGVLLKG 679
T+V + L R R Y+ + L N TV V DVND +
Sbjct: 395 PSVENFYTLVSEGALDRETRSEYNITITITDLGTPRLKTKYNITVLVSDVNDNAPAFTQI 454
Query: 680 AHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD----VTDDIAI-AE 734
+++ +F + NS IG + T+ S V + + QD ++ ++I A+
Sbjct: 455 SYT--LFVRENNSPALHIGSVSATDRDS---GTNAQVTYSLLPPQDPHLPLSSLVSINAD 509
Query: 735 DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEG 794
+G +F + LD E + V A ++G + + V + + D NDN P + G
Sbjct: 510 NGHLFALRSLDYEALQAFEFRVGAT-DRGSPALSSEALVRVLVLDANDNSPFVLYPLQNG 568
Query: 795 FIMENSKIGTEIKMDNIIK---ATDADEGTNALFMYTLFGEGKE-MFDVDENTGVVKFIG 850
+ + ++ A D D G NA Y L + +F V + G V+
Sbjct: 569 SAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVR-TA 627
Query: 851 DSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
L ++L ++ +D G S+ A L +++ D
Sbjct: 628 RLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD 664
Score = 63.3 bits (147), Expect = 6e-09
Identities = 43/171 (25%), Positives = 83/171 (48%), Gaps = 7/171 (4%)
Query: 219 HAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQA 278
+A D D+G + Y + + + + +G + E LD + Q L + A
Sbjct: 156 NAEDLDVGRNSLQNYTITPNSHFHVLTRSRRDGRKYPELVLDKALDREEQPE-LSLTLTA 214
Query: 279 SQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGEN 338
+P ++ A++ I++LD+NDN PEF Y ++++EN P ++ V A+D D G
Sbjct: 215 LDGGSPPRSGTAQINIQVLDINDNAPEFAQPLYEVAVLENTPVNSVIVTVSASDLDTGSF 274
Query: 339 GEFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
G +Y ++ + F ++P +G ++ L+ EA +S + + AK+
Sbjct: 275 GTISYAFFHASEEIRKTFQLNPITG--DMQLVKYLNFEAINSYEVDIEAKD 323
Score = 62.1 bits (144), Expect = 1e-08
Identities = 56/181 (30%), Positives = 85/181 (46%), Gaps = 20/181 (11%)
Query: 218 IHAIDQDLGVGATLRYELISGND-----RKLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A D+D G A + Y L+ D L S+++ NG LF + LD +A LQA F
Sbjct: 473 VSATDRDSGTNAQVTYSLLPPQDPHLPLSSLVSINADNGHLFALRSLDYEA---LQA--F 527
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNIS--IVENLPN----GFSVL 326
+V A+ +P +++A V + +LD NDN P N S E +P G+ V
Sbjct: 528 EFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVT 587
Query: 327 QVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAK 384
+V+A D D G+N +YQL G F + +G VR +L + R+ V K
Sbjct: 588 KVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG--EVRTARLLSERDAAKHRLVVLVK 645
Query: 385 E 385
+
Sbjct: 646 D 646
Score = 59.7 bits (138), Expect = 8e-08
Identities = 59/204 (28%), Positives = 84/204 (41%), Gaps = 18/204 (8%)
Query: 933 QLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYF 992
Q+ + EN I ++A D DSG N Q+ Y +PP L +
Sbjct: 453 QISYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSL-----LPPQD---PHLPLSSLV 504
Query: 993 VINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKT 1048
IN +GH+ RSL E+ F + A D G+ L+ VRV V D ND+ P
Sbjct: 505 SINADNGHLFALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYP 564
Query: 1049 WYNFN------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVL 1102
N + V A ++ KV A D D GQNA L+Y + + F + G +
Sbjct: 565 LQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEV 624
Query: 1103 SVNGELDRETEDKYILTVVARDNG 1126
L K+ L V+ +DNG
Sbjct: 625 RTARLLSERDAAKHRLVVLVKDNG 648
Score = 59.3 bits (137), Expect = 1e-07
Identities = 44/167 (26%), Positives = 81/167 (48%), Gaps = 12/167 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGND--RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A D D G T+ Y ++ RK F L+ + G + L K L+ +A N++ +
Sbjct: 264 VSASDLDTGSFGTISYAFFHASEEIRKTFQLNPITGDMQLVKYLNFEA-----INSYEVD 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA-TDKD 334
++A + ++ V ++++D+NDN PE + N I EN +G +VL V + +D D
Sbjct: 319 IEAKDGGG--LSGKSTVIVQVVDVNDNPPELTLSSVNSPIPEN--SGETVLAVFSVSDLD 374
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKV 381
G+NG +++ F + T+ ++ LDRE S + +
Sbjct: 375 SGDNGRVMCSIENNLPFFLKPSVENFYTLVSEGALDRETRSEYNITI 421
Score = 50.8 bits (116), Expect = 4e-05
Identities = 36/126 (28%), Positives = 52/126 (41%), Gaps = 3/126 (2%)
Query: 224 DLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNN 283
DL G R N+ F SV L E LD E + N + + + L
Sbjct: 372 DLDSGDNGRVMCSIENNLPFFLKPSVENFYTLVSEGALDRETRSEYN---ITITITDLGT 428
Query: 284 PLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTY 343
P + + + + D+NDN P F Y + + EN + V ATD+D G N + TY
Sbjct: 429 PRLKTKYNITVLVSDVNDNAPAFTQISYTLFVRENNSPALHIGSVSATDRDSGTNAQVTY 488
Query: 344 QLDDPK 349
L P+
Sbjct: 489 SLLPPQ 494
Score = 50.4 bits (115), Expect = 5e-05
Identities = 43/172 (25%), Positives = 72/172 (41%), Gaps = 9/172 (5%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
K L+ E + Y + + A+ G+ +G V + + D NDNPP ++ I ENS
Sbjct: 305 KYLNFEAINSYEVDIEAKDGGGL---SGKSTVIVQVVDVNDNPPELTLSSVNSPIPENS- 360
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMY 861
G + + +D D G N M ++ +LDRE + Y
Sbjct: 361 -GETVLA--VFSVSDLDSGDNGRVMCSIENNLPFFLKPSVENFYTLVSEGALDRETRSEY 417
Query: 862 KLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
+++ D G L ++ + +++ D NDN P F QI VR + L+
Sbjct: 418 NITITITDLGTPRLKTKYNITVLVSDVNDNAPAFTQISYTLFVRENNSPALH 469
Score = 48.8 bits (111), Expect = 1e-04
Identities = 36/119 (30%), Positives = 53/119 (44%), Gaps = 5/119 (4%)
Query: 1037 DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEIS 1096
DVNDH PVF + + + E+ V+ +A D D G+N+ Y I P+ S
Sbjct: 125 DVNDHSPVFFENEMHLKILESTLPGTVIPLGNAEDLDVGRNSLQNYTITPNSHFHVLTRS 184
Query: 1097 PLTG----VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
G L ++ LDRE + + LT+ A D G D+NDN+P+F
Sbjct: 185 RRDGRKYPELVLDKALDREEQPELSLTLTALDGG-SPPRSGTAQINIQVLDINDNAPEF 242
Score = 46.0 bits (104), Expect = 0.001
Identities = 68/244 (27%), Positives = 102/244 (41%), Gaps = 20/244 (8%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L + N+ V + D NDN P F + Y ++ N IG V A D D G N V Y
Sbjct: 430 RLKTKYNITVLVSDVNDNAPAFTQIS-YTLFVRENNSPALHIGSVSATDRDSGTNAQVTY 488
Query: 498 DL--QRTSNLTITSPFKINPNTGTVSVAESPILEGRHA--LFVEASDQ--PANPSERRYS 551
L + +L ++S IN + G + S E A V A+D+ PA SE
Sbjct: 489 SLLPPQDPHLPLSSLVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPALSSE---- 544
Query: 552 LAVVTIEVTRGTKGNKPDI--PDFMG-APYEFWVGSNVGIGTSVGQIRV--NDAFEQNDV 606
A+V + V N P + P G AP V G V ++ D+ + +
Sbjct: 545 -ALVRVLVL-DANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWL 602
Query: 607 SYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHV 666
SY LL E G+ F V +G + LS + + V +++N AT+HV
Sbjct: 603 SYQLLKATEPGL-FGVWAHNGEVRTARLLSERDAAKHRL-VVLVKDNGEPPRSATATLHV 660
Query: 667 VDVN 670
+ V+
Sbjct: 661 LLVD 664
Score = 39.5 bits (88), Expect = 0.091
Identities = 34/125 (27%), Positives = 58/125 (46%), Gaps = 5/125 (4%)
Query: 234 ELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVE 293
+++S +++ F L G L L ++LD + E +L Q L NPL+ E
Sbjct: 65 QVVSKGNKQHFQLSHQTGDLLLNEKLDRE-ELCGPTEPCILHFQIL-LQNPLQFVTN--E 120
Query: 294 IELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFS 353
+ ++D+ND+ P F + ++ I+E+ G + A D D G N Y + P F
Sbjct: 121 LRIIDVNDHSPVFFENEMHLKILESTLPGTVIPLGNAEDLDVGRNSLQNYTI-TPNSHFH 179
Query: 354 IDPRS 358
+ RS
Sbjct: 180 VLTRS 184
>AF152522-1|AAD43782.1| 820|Homo sapiens protocadherin gamma B6
short form protein protein.
Length = 820
Score = 111 bits (268), Expect = 1e-23
Identities = 121/477 (25%), Positives = 200/477 (41%), Gaps = 39/477 (8%)
Query: 432 IEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQ 491
+E E ++ +V V + D ND+ P F ++ + +A GT + A DPD+
Sbjct: 106 LEAVVENPLNIFHVIVVIEDVNDHAPQFDKKEIH-LEIFESASAGTRLSLDPATDPDINI 164
Query: 492 NGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR-----HALFVEASDQPANPS 546
N + Y + SN + ++N + G L R H+L + A D P
Sbjct: 165 NSIKDYKIN--SNPYFSLMVRVNSDGGKYPELSLEKLLDREEQRSHSLILTALDGGDPPR 222
Query: 547 ERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QN 604
A IE++ + P P F Y + N+ G+ V Q+ D E
Sbjct: 223 S-----ATAHIEISVKDTNDNP--PVFSRDEYRISLSENLPPGSPVLQVTATDQDEGVNA 275
Query: 605 DVSYDLLHGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNAT 663
+++Y + F+++E++G+I + Y E A ++ LS
Sbjct: 276 EINYYFRSTAQSTKHMFSLDEKTGMIKNNQSFDFEDVERYTMEVEA-KDGGGLSTQCKVI 334
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
+ ++D ND ++ + S I ENS + +F T GNG VR I +
Sbjct: 335 IEILDENDNSPEIIITSLSDQIL---ENSPPGMVVALFKTRDLDFGGNG--EVRCNI--E 387
Query: 724 QDVTDDIAIAEDG--TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
D+ I + + + T LDRE+ Y +T++A ++G + +T+Y+ D N
Sbjct: 388 TDIPFKIYSSSNNYYKLVTDGALDREQTPEYNVTIVAT-DRGKPPLSSSRSITLYVADIN 446
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDE 841
DN PVF+ +Y + EN+ G I + A+D D G N Y++ E V
Sbjct: 447 DNAPVFDQTSYVVHVAENNPPGASIAQ---VSASDPDLGLNGHISYSIVASDLEPLAVSS 503
Query: 842 NTGV-----VKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKP 891
V V F + D E+ + L+L ARD G LS+ L +++GD NDN P
Sbjct: 504 YVSVSAQSGVVFAQRAFDHEQLRAFALTLQARDHGSPTLSANVSLRVLVGDRNDNAP 560
Score = 94.3 bits (224), Expect = 3e-18
Identities = 99/344 (28%), Positives = 155/344 (45%), Gaps = 29/344 (8%)
Query: 574 MGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVD 633
+ P + + + G+ VG + + DVS L E + F+V+ SG + V +
Sbjct: 29 LSEPIRYSIPEELAKGSVVGNLAKDLGLSVLDVSARKLRVSAEKLHFSVDAESGDLLVKN 88
Query: 634 DLSRYN----RPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVK 689
+ R R + + A+ EN L+I + V + DVND K IF +
Sbjct: 89 RIDREQICKERRRCELQLEAVVENP-LNIF-HVIVVIEDVNDHAPQFDKKEIHLEIF--E 144
Query: 690 ENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDG----TIFTQKPLD 745
SAG + T+ I N + + I + + + + DG + +K LD
Sbjct: 145 SASAGTRLSLDPATD-PDININSIKDYK--INSNPYFSLMVRVNSDGGKYPELSLEKLLD 201
Query: 746 REKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTE 805
RE++ + + ++ + G + + I ++D NDNPPVF Y + EN G+
Sbjct: 202 REEQRSHSL-ILTALDGGDPPRSATAHIEISVKDTNDNPPVFSRDEYRISLSENLPPGSP 260
Query: 806 IKMDNIIKATDADEGTNALFMYTLFGEG---KEMFDVDENTGVVKFIGDSLDREKKIMYK 862
+ + ATD DEG NA Y K MF +DE TG++K S D E Y
Sbjct: 261 VLQ---VTATDQDEGVNAEINYYFRSTAQSTKHMFSLDEKTGMIKN-NQSFDFEDVERYT 316
Query: 863 LSLVARDTGGLSSEAELIIMIGDENDNKPEF------NQIEENS 900
+ + A+D GGLS++ ++II I DENDN PE +QI ENS
Sbjct: 317 MEVEAKDGGGLSTQCKVIIEILDENDNSPEIIITSLSDQILENS 360
Score = 82.2 bits (194), Expect = 1e-14
Identities = 62/217 (28%), Positives = 97/217 (44%), Gaps = 20/217 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN+P G+ ++++ A D D G+N +I Y F S A K F ++E+ G
Sbjct: 251 LSENLPPGSPVLQVTATDQDEGVNAEINYYFRS-----------TAQSTKHMFSLDEKTG 299
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ +S E + + + A DGG L+ V + + D ND+ P T + + E
Sbjct: 300 MIKNNQSFDFEDVERYTMEVEAKDGGGLSTQCKVIIEILDENDNSPEIIITSLSDQILEN 359
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
V+ D DFG N + I +TD+PF+I + L +G LDRE
Sbjct: 360 SPPGMVVALFKTRDLDFGGNGEVRCNI---ETDIPFKIYSSSNNYYKLVTDGALDREQTP 416
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
+Y +T+VA D G D+NDN+P F
Sbjct: 417 EYNVTIVATDRG-KPPLSSSRSITLYVADINDNAPVF 452
Score = 81.4 bits (192), Expect = 2e-14
Identities = 58/172 (33%), Positives = 87/172 (50%), Gaps = 11/172 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELD--LDAEHNLQANTFVLQVQ 277
A D D+ + + Y++ S L + +G + E L+ LD E ++++ +L
Sbjct: 157 ATDPDININSIKDYKINSNPYFSLMVRVNSDGGKYPELSLEKLLDREEQ-RSHSLILT-- 213
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A +P ++A A +EI + D NDN P F D Y IS+ ENLP G VLQV ATD+D+G
Sbjct: 214 ALDGGDPPRSATAHIEISVKDTNDNPPVFSRDEYRISLSENLPPGSPVLQVTATDQDEGV 273
Query: 338 NGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N E Y K FS+D ++G ++N D E M+V AK+
Sbjct: 274 NAEINYYFRSTAQSTKHMFSLDEKTG--MIKNNQSFDFEDVERYTMEVEAKD 323
Score = 77.0 bits (181), Expect = 5e-13
Identities = 77/300 (25%), Positives = 131/300 (43%), Gaps = 21/300 (7%)
Query: 858 KIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFT 917
+I Y A+ T + S E MI +N+ +F +E + ++ T
Sbjct: 276 EINYYFRSTAQSTKHMFSLDEKTGMI--KNNQSFDFEDVERYTMEVEAKDGGGLSTQCKV 333
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
IIE+ +N + ++ I EN P G + DLD G NG++R +++
Sbjct: 334 IIEILDENDNSPEIIITSLSDQILENSPPGMVVALFKTRDLDFGGNGEVRCNIETDI--- 390
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFV 1035
P K+ + + Y ++ + + R PE + + I A D G L+ + S+ ++V
Sbjct: 391 PFKIYSSSNNY--YKLVTDG----ALDREQTPE--YNVTIVATDRGKPPLSSSRSITLYV 442
Query: 1036 KDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTD----- 1090
D+ND+ PVF +T Y +V E + +V A+D D G N +++Y I SD +
Sbjct: 443 ADINDNAPVFDQTSYVVHVAENNPPGASIAQVSASDPDLGLNGHISYSIVASDLEPLAVS 502
Query: 1091 LPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
+S +GV+ D E + LT+ ARD+G D NDN+P+
Sbjct: 503 SYVSVSAQSGVVFAQRAFDHEQLRAFALTLQARDHG-SPTLSANVSLRVLVGDRNDNAPR 561
Score = 65.7 bits (153), Expect = 1e-09
Identities = 68/255 (26%), Positives = 109/255 (42%), Gaps = 21/255 (8%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
I+ ++ N A D+ I E+ GT + A D D +N Y+ NS Y
Sbjct: 120 IVVIEDVNDHAPQFDKKEIHLEIFESASAGTRLSLDPATDPDININSIKDYKINSNPYF- 178
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGGN--LNDNISVRV 1033
+L V R ++ + + + L E + L ++ALDGG+ + + +
Sbjct: 179 -------SLMV-RVNSDGGKYPELSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEI 230
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS--DTDL 1091
VKD ND+ PVF + Y ++ E + +V ATD D G NA + Y+ + + T
Sbjct: 231 SVKDTNDNPPVFSRDEYRISLSENLPPGSPVLQVTATDQDEGVNAEINYYFRSTAQSTKH 290
Query: 1092 PFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
F + TG++ N D E ++Y + V A+D G D NDNSP+
Sbjct: 291 MFSLDEKTGMIKNNQSFDFEDVERYTMEVEAKDGG---GLSTQCKVIIEILDENDNSPEI 347
Query: 1152 Y---AFDELLEWKHP 1163
D++LE P
Sbjct: 348 IITSLSDQILENSPP 362
Score = 64.1 bits (149), Expect = 4e-09
Identities = 66/207 (31%), Positives = 93/207 (44%), Gaps = 21/207 (10%)
Query: 932 DQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRY 991
DQ + + EN P G +I +++A D D GLNG I Y I S L + L V Y
Sbjct: 453 DQTSYVVHVAENNPPGASIAQVSASDPDLGLNGHISYS------IVASDL--EPLAVSSY 504
Query: 992 FVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDH-----F 1042
++ + G V R+ E F L + A D G+ L+ N+S+RV V D ND+ +
Sbjct: 505 VSVSAQSGVVFAQRAFDHEQLRAFALTLQARDHGSPTLSANVSLRVLVGDRNDNAPRVLY 564
Query: 1043 PVFKKTWYNF--NVEEAQYTRRVLGKVDATDADFGQNANLTYFI-QPSDTDLPFEISPLT 1099
P F V + ++ KV A DAD G NA L+Y + Q S+ L F + T
Sbjct: 565 PALGPDGSAFFDMVPRSAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGL-FSLGLRT 623
Query: 1100 GVLSVNGELDRETEDKYILTVVARDNG 1126
G + L + L V RD G
Sbjct: 624 GEVRTARALGDRDAARQRLLVAVRDGG 650
Score = 60.5 bits (140), Expect = 5e-08
Identities = 67/282 (23%), Positives = 117/282 (41%), Gaps = 27/282 (9%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRG 137
SA + + ++D NDN P+F Y +++ E P G + +
Sbjct: 223 SATAHIEISVKDTNDNPPVFSRDEYRISLSENLPPGSPVLQVTATDQDEGVNAEINYYFR 282
Query: 138 LTIFKDIRAFDRDKP-----NTPNSDVH----YSI-VSGNDDGHFALESSHKPVLLLRKV 187
T F D+ N + D Y++ V D G L + K ++ ++
Sbjct: 283 STAQSTKHMFSLDEKTGMIKNNQSFDFEDVERYTMEVEAKDGG--GLSTQCKVII---EI 337
Query: 188 LDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGATLRYELISGNDRKL 243
LD + D +++I + +I E P + A+ D D G +R + + K+
Sbjct: 338 LDEN--DNSPEIIITSLSDQI-LENSPPGMVVALFKTRDLDFGGNGEVRCNIETDIPFKI 394
Query: 244 FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNL 303
+S S N L + LD E + N ++ A+ P ++ + + + D+NDN
Sbjct: 395 YS--SSNNYYKLVTDGALDREQTPEYNVTIV---ATDRGKPPLSSSRSITLYVADINDNA 449
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
P F+ Y + + EN P G S+ QV A+D D G NG +Y +
Sbjct: 450 PVFDQTSYVVHVAENNPPGASIAQVSASDPDLGLNGHISYSI 491
Score = 60.1 bits (139), Expect = 6e-08
Identities = 55/206 (26%), Positives = 86/206 (41%), Gaps = 14/206 (6%)
Query: 218 IHAIDQDLGVGATLRYELISG--NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A DQD GV A + Y S + + +FSLD G + + D + + ++
Sbjct: 264 VTATDQDEGVNAEINYYFRSTAQSTKHMFSLDEKTGMIKNNQSFDFE-----DVERYTME 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
V+A L T Q +V IE+LD NDN PE + + I+EN P G V D D
Sbjct: 319 VEAKD-GGGLST-QCKVIIEILDENDNSPEIIITSLSDQILENSPPGMVVALFKTRDLDF 376
Query: 336 GENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
G NGE ++ + + + LDRE + + A + +
Sbjct: 377 GGNGEVRCNIETDIPFKIYSSSNNYYKLVTDGALDREQTPEYNVTIVATDRGKPPL---- 432
Query: 396 DSQRIAKWRRQPLETNAPL-EKTTYV 420
S R + NAP+ ++T+YV
Sbjct: 433 SSSRSITLYVADINDNAPVFDQTSYV 458
Score = 50.4 bits (115), Expect = 5e-05
Identities = 89/371 (23%), Positives = 148/371 (39%), Gaps = 52/371 (14%)
Query: 37 AQSIDSLVDSDSPQNVVKFRLGCDFDEGDDLV-----RIGAGLNQISAYLSVTVYIEDVN 91
AQS + D ++K DF++ + + G GL S V + I D N
Sbjct: 285 AQSTKHMFSLDEKTGMIKNNQSFDFEDVERYTMEVEAKDGGGL---STQCKVIIEILDEN 341
Query: 92 DNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIG------PSLTIPLTVPRGL-----TI 140
DN P + T + E +P G +F + I +P +
Sbjct: 342 DNSPEIIITSLSDQILENSPPGMVVALFKTRDLDFGGNGEVRCNIETDIPFKIYSSSNNY 401
Query: 141 FKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDY-DAGDKEFQL 199
+K + D+ TP +V +IV+ D G L SS L + + D D+ +
Sbjct: 402 YKLVTDGALDREQTPEYNV--TIVA-TDRGKPPLSSSRSITLYVADINDNAPVFDQTSYV 458
Query: 200 VIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKL-----FSLDSVNGSLF 254
V +A I + A D DLG+ + Y +++ + L S+ + +G +F
Sbjct: 459 VHVAENNPPGASIA---QVSASDPDLGLNGHISYSIVASDLEPLAVSSYVSVSAQSGVVF 515
Query: 255 LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD----- 309
++ D + Q F L +QA +P +A + + + D NDN P
Sbjct: 516 AQRAFDHE-----QLRAFALTLQARDHGSPTLSANVSLRVLVGDRNDNAPRVLYPALGPD 570
Query: 310 ---FYNISIVENLPNGFSVLQVMATDKDQGENGEFTY---QLDDPKGAFSIDPRSGWLTV 363
F+++ + + G+ V +V+A D D G N +Y Q +P G FS+ R+G V
Sbjct: 571 GSAFFDM-VPRSAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEP-GLFSLGLRTG--EV 626
Query: 364 RNQTVL-DREA 373
R L DR+A
Sbjct: 627 RTARALGDRDA 637
Score = 41.9 bits (94), Expect = 0.017
Identities = 46/173 (26%), Positives = 67/173 (38%), Gaps = 12/173 (6%)
Query: 989 KRYFVINERHGHVIVARSLPPES------EFRLNISALDGGNLNDNISVRVFVKDVNDHF 1042
K +F ++ G ++V + E L + A+ LN V V ++DVNDH
Sbjct: 72 KLHFSVDAESGDLLVKNRIDREQICKERRRCELQLEAVVENPLNI-FHVIVVIEDVNDHA 130
Query: 1043 PVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD-TDLPFEISPLTG- 1100
P F K + + E+ L ATD D N+ Y I + L ++ G
Sbjct: 131 PQFDKKEIHLEIFESASAGTRLSLDPATDPDININSIKDYKINSNPYFSLMVRVNSDGGK 190
Query: 1101 --VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
LS+ LDRE + + L + A D G D NDN P F
Sbjct: 191 YPELSLEKLLDREEQRSHSLILTALDGG-DPPRSATAHIEISVKDTNDNPPVF 242
Score = 38.3 bits (85), Expect = 0.21
Identities = 29/103 (28%), Positives = 52/103 (50%), Gaps = 4/103 (3%)
Query: 244 FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNL 303
FS+D+ +G L ++ +D + + + LQ++A + NPL V IE D+ND+
Sbjct: 75 FSVDAESGDLLVKNRIDRE-QICKERRRCELQLEAV-VENPLNIFHVIVVIE--DVNDHA 130
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
P+F+ ++ I E+ G + ATD D N Y+++
Sbjct: 131 PQFDKKEIHLEIFESASAGTRLSLDPATDPDININSIKDYKIN 173
>AF152496-1|AAD43757.1| 796|Homo sapiens protocadherin beta 3
protein.
Length = 796
Score = 111 bits (268), Expect = 1e-23
Identities = 122/467 (26%), Positives = 203/467 (43%), Gaps = 36/467 (7%)
Query: 440 MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
+ FV E+ ++D ND++PVF + ++ ++S GTVI A D D+G+N + Y +
Sbjct: 114 LQFVTNELRIIDVNDHSPVFFENEMHLKILESTLP-GTVIPLGNAEDLDVGRNSLQNYTI 172
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLAVVT 556
S+ + + + + V + + + +L + A D + P R A +
Sbjct: 173 TPNSHFHVLTRSRRDGRKYPELVLDKALDREEQPELSLTLTALDGGSPP---RSGTAQIN 229
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN--DAFEQNDVSYDLLHGY 614
I+V + P+F YE V N + + + + + D +SY H
Sbjct: 230 IQVL----DINDNAPEFAQPLYEVAVLENTPVNSVIVTVSASDLDTGSFGTISYAFFHAS 285
Query: 615 EE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDER 673
EE F + +G + +V L+ Y+ + + ++ LS + V VVDVND
Sbjct: 286 EEIRKTFQLNPITGDMQLVKYLNFEAINSYEVD-IEAKDGGGLSGKSTVIVQVVDVNDNP 344
Query: 674 GVL-LKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI 732
L L +SPI ENS G + +F ++S + G V I N ++
Sbjct: 345 PELTLSSVNSPI----PENS-GETVLAVF--SVSDLDSGDNGRVMCSIENNLPFFLKPSV 397
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
T+ ++ LDRE R Y +T+ + G Y +T+ + D NDN P F +Y
Sbjct: 398 ENFYTLVSEGALDRETRSEYNITITIT-DLGTPRLKTKYNITVLVSDVNDNAPAFTQISY 456
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDENTGVV 846
F+ EN+ I + ATD D GTNA Y+L + ++ + G +
Sbjct: 457 TLFVRENNSPALHI---GSVSATDRDSGTNAQVTYSLLPPQDPHLPLSSLVSINADNGHL 513
Query: 847 KFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
F SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 514 -FALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDNSP 559
Score = 80.6 bits (190), Expect = 4e-14
Identities = 58/222 (26%), Positives = 106/222 (47%), Gaps = 9/222 (4%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
K LDRE++ +T+ A + G +G Q+ I + D NDN P F YE ++EN+
Sbjct: 198 KALDREEQPELSLTLTA-LDGGSPPRSGTAQINIQVLDINDNAPEFAQPLYEVAVLENTP 256
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM---FDVDENTGVVKFIGDSLDREKK 858
+ + I + A+D D G+ Y F +E+ F ++ TG ++ + L+ E
Sbjct: 257 VNSVIVT---VSASDLDTGSFGTISYAFFHASEEIRKTFQLNPITGDMQLV-KYLNFEAI 312
Query: 859 IMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTI 918
Y++ + A+D GGLS ++ +I+ + D NDN PE NS + + + +
Sbjct: 313 NSYEVDIEAKDGGGLSGKSTVIVQVVDVNDNPPELTLSSVNSPIPENSGETVLAVFSVSD 372
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDS 960
++ + ++ P FL P ++ T++ ALD ++
Sbjct: 373 LDSGDNGRVMCSIENNLPFFLKP-SVENFYTLVSEGALDRET 413
Score = 77.4 bits (182), Expect = 4e-13
Identities = 121/502 (24%), Positives = 205/502 (40%), Gaps = 76/502 (15%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEF--NSEVYIPPSKLSADALEVKRYFVI 994
L ++ +P GT I NA DLD G N Y NS ++ L+ + ++Y
Sbjct: 140 LKILESTLP-GTVIPLGNAEDLDVGRNSLQNYTITPNSHFHV----LTRSRRDGRKY--- 191
Query: 995 NERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWY 1050
+++ ++L E E L ++ALDGG+ + + + V D+ND+ P F + Y
Sbjct: 192 ----PELVLDKALDREEQPELSLTLTALDGGSPPRSGTAQINIQVLDINDNAPEFAQPLY 247
Query: 1051 NFNVEEAQYTRRVLGKVDATDADFGQNANLTY--FIQPSDTDLPFEISPLTGVLSVNGEL 1108
V E V+ V A+D D G ++Y F + F+++P+TG + + L
Sbjct: 248 EVAVLENTPVNSVIVTVSASDLDTGSFGTISYAFFHASEEIRKTFQLNPITGDMQLVKYL 307
Query: 1109 DRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADEL 1168
+ E + Y + + A+D G DVNDN P+ L P +
Sbjct: 308 NFEAINSYEVDIEAKDGG---GLSGKSTVIVQVVDVNDNPPEL----TLSSVNSP----I 356
Query: 1169 SNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDF----IGNGNGLILYSLPQRKNQ 1224
++ E+V + V+ + ++ G + + N F + N L+ R+ +
Sbjct: 357 PENSGETV--LAVFSVSDLDSGDNGRVMCSIENNLPFFLKPSVENFYTLVSEGALDRETR 414
Query: 1225 Q---------NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVE 1275
+LG P L + + V V+DV D + P F Y L + EN + +
Sbjct: 415 SEYNITITITDLGTPRLKTKYNITVLVSDVND-----NAPAFTQISYTLFVRENNSPALH 469
Query: 1276 LVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREVKDTYEV 1331
+ S++ T+ N ++ Y +L D + + + I+ NG L+ +RS D E +E
Sbjct: 470 IGSVSATDRDSGTNAQVTYSLLPPQDPHLPLSSLVSINADNGHLFALRSLDYEALQAFEF 529
Query: 1332 IVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTNGNRPL 1387
V A R P + + V V + D NDNSP NG+ P
Sbjct: 530 RVGAT----DRGSPAL-------------SSEALVRVLVLDANDNSPFVLYPLQNGSAPC 572
Query: 1388 VTAIPTTAPFGYQVMQLKGAIG 1409
+P A GY V ++ G
Sbjct: 573 TELVPRAAEPGYLVTKVVAVDG 594
Score = 76.2 bits (179), Expect = 9e-13
Identities = 69/235 (29%), Positives = 103/235 (43%), Gaps = 28/235 (11%)
Query: 929 LDVDQLGPLFLIP-------ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD++ P F P EN P+ + I+ ++A DLD+G G I Y F
Sbjct: 233 LDINDNAPEFAQPLYEVAVLENTPVNSVIVTVSASDLDTGSFGTISYAFFHA-------- 284
Query: 982 SADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGNLNDNISVRVFVKDVN 1039
+ E+++ F +N G + + + L E+ + ++I A DGG L+ +V V V DVN
Sbjct: 285 ---SEEIRKTFQLNPITGDMQLVKYLNFEAINSYEVDIEAKDGGGLSGKSTVIVQVVDVN 341
Query: 1040 DHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLT 1099
D+ P + N + E VL +D D G N + I + +LPF + P
Sbjct: 342 DNPPELTLSSVNSPIPE-NSGETVLAVFSVSDLDSGDNGRVMCSI---ENNLPFFLKPSV 397
Query: 1100 G---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
L G LDRET +Y +T+ D G DVNDN+P F
Sbjct: 398 ENFYTLVSEGALDRETRSEYNITITITDLG-TPRLKTKYNITVLVSDVNDNAPAF 451
Score = 71.3 bits (167), Expect = 2e-11
Identities = 106/457 (23%), Positives = 188/457 (41%), Gaps = 36/457 (7%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
+ + +LD NDN P F LYE ++ N V +VI V A D D G G + Y S
Sbjct: 228 INIQVLDINDNAPEFAQP-LYEVAVLENTPVNSVIVTVSASDLDTGSFGTISYAFFHASE 286
Query: 505 LTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRGTK 564
I F++NP TG + + + E ++ V+ + + ++ V ++V
Sbjct: 287 -EIRKTFQLNPITGDMQLVKYLNFEAINSYEVDIEAKDGGGLSGKSTVIVQVVDV----N 341
Query: 565 GNKPDIP-DFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVE 623
N P++ + +P + N G T + V+D + D + ++ E +PF ++
Sbjct: 342 DNPPELTLSSVNSP----IPENSG-ETVLAVFSVSD-LDSGD-NGRVMCSIENNLPFFLK 394
Query: 624 ER-SGVITVVDD--LSRYNRPMYDFE-AVALQENANLSIVTNATVHVVDVNDERGVLLKG 679
T+V + L R R Y+ + L N TV V DVND +
Sbjct: 395 PSVENFYTLVSEGALDRETRSEYNITITITDLGTPRLKTKYNITVLVSDVNDNAPAFTQI 454
Query: 680 AHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQD----VTDDIAI-AE 734
+++ +F + NS IG + T+ S V + + QD ++ ++I A+
Sbjct: 455 SYT--LFVRENNSPALHIGSVSATDRDS---GTNAQVTYSLLPPQDPHLPLSSLVSINAD 509
Query: 735 DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEG 794
+G +F + LD E + V A ++G + + V + + D NDN P + G
Sbjct: 510 NGHLFALRSLDYEALQAFEFRVGAT-DRGSPALSSEALVRVLVLDANDNSPFVLYPLQNG 568
Query: 795 FIMENSKIGTEIKMDNIIK---ATDADEGTNALFMYTLFGEGKE-MFDVDENTGVVKFIG 850
+ + ++ A D D G NA Y L + +F V + G V+
Sbjct: 569 SAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVR-TA 627
Query: 851 DSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
L ++L ++ +D G S+ A L +++ D
Sbjct: 628 RLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVD 664
Score = 63.3 bits (147), Expect = 6e-09
Identities = 43/171 (25%), Positives = 83/171 (48%), Gaps = 7/171 (4%)
Query: 219 HAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQA 278
+A D D+G + Y + + + + +G + E LD + Q L + A
Sbjct: 156 NAEDLDVGRNSLQNYTITPNSHFHVLTRSRRDGRKYPELVLDKALDREEQPE-LSLTLTA 214
Query: 279 SQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGEN 338
+P ++ A++ I++LD+NDN PEF Y ++++EN P ++ V A+D D G
Sbjct: 215 LDGGSPPRSGTAQINIQVLDINDNAPEFAQPLYEVAVLENTPVNSVIVTVSASDLDTGSF 274
Query: 339 GEFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
G +Y ++ + F ++P +G ++ L+ EA +S + + AK+
Sbjct: 275 GTISYAFFHASEEIRKTFQLNPITG--DMQLVKYLNFEAINSYEVDIEAKD 323
Score = 62.1 bits (144), Expect = 1e-08
Identities = 56/181 (30%), Positives = 85/181 (46%), Gaps = 20/181 (11%)
Query: 218 IHAIDQDLGVGATLRYELISGND-----RKLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A D+D G A + Y L+ D L S+++ NG LF + LD +A LQA F
Sbjct: 473 VSATDRDSGTNAQVTYSLLPPQDPHLPLSSLVSINADNGHLFALRSLDYEA---LQA--F 527
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNIS--IVENLPN----GFSVL 326
+V A+ +P +++A V + +LD NDN P N S E +P G+ V
Sbjct: 528 EFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVT 587
Query: 327 QVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAK 384
+V+A D D G+N +YQL G F + +G VR +L + R+ V K
Sbjct: 588 KVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG--EVRTARLLSERDAAKHRLVVLVK 645
Query: 385 E 385
+
Sbjct: 646 D 646
Score = 59.7 bits (138), Expect = 8e-08
Identities = 59/204 (28%), Positives = 84/204 (41%), Gaps = 18/204 (8%)
Query: 933 QLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYF 992
Q+ + EN I ++A D DSG N Q+ Y +PP L +
Sbjct: 453 QISYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSL-----LPPQD---PHLPLSSLV 504
Query: 993 VINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKT 1048
IN +GH+ RSL E+ F + A D G+ L+ VRV V D ND+ P
Sbjct: 505 SINADNGHLFALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYP 564
Query: 1049 WYNFN------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVL 1102
N + V A ++ KV A D D GQNA L+Y + + F + G +
Sbjct: 565 LQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEV 624
Query: 1103 SVNGELDRETEDKYILTVVARDNG 1126
L K+ L V+ +DNG
Sbjct: 625 RTARLLSERDAAKHRLVVLVKDNG 648
Score = 59.3 bits (137), Expect = 1e-07
Identities = 44/167 (26%), Positives = 81/167 (48%), Gaps = 12/167 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGND--RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A D D G T+ Y ++ RK F L+ + G + L K L+ +A N++ +
Sbjct: 264 VSASDLDTGSFGTISYAFFHASEEIRKTFQLNPITGDMQLVKYLNFEA-----INSYEVD 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA-TDKD 334
++A + ++ V ++++D+NDN PE + N I EN +G +VL V + +D D
Sbjct: 319 IEAKDGGG--LSGKSTVIVQVVDVNDNPPELTLSSVNSPIPEN--SGETVLAVFSVSDLD 374
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKV 381
G+NG +++ F + T+ ++ LDRE S + +
Sbjct: 375 SGDNGRVMCSIENNLPFFLKPSVENFYTLVSEGALDRETRSEYNITI 421
Score = 50.8 bits (116), Expect = 4e-05
Identities = 36/126 (28%), Positives = 52/126 (41%), Gaps = 3/126 (2%)
Query: 224 DLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNN 283
DL G R N+ F SV L E LD E + N + + + L
Sbjct: 372 DLDSGDNGRVMCSIENNLPFFLKPSVENFYTLVSEGALDRETRSEYN---ITITITDLGT 428
Query: 284 PLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTY 343
P + + + + D+NDN P F Y + + EN + V ATD+D G N + TY
Sbjct: 429 PRLKTKYNITVLVSDVNDNAPAFTQISYTLFVRENNSPALHIGSVSATDRDSGTNAQVTY 488
Query: 344 QLDDPK 349
L P+
Sbjct: 489 SLLPPQ 494
Score = 50.4 bits (115), Expect = 5e-05
Identities = 43/172 (25%), Positives = 72/172 (41%), Gaps = 9/172 (5%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
K L+ E + Y + + A+ G+ +G V + + D NDNPP ++ I ENS
Sbjct: 305 KYLNFEAINSYEVDIEAKDGGGL---SGKSTVIVQVVDVNDNPPELTLSSVNSPIPENS- 360
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMY 861
G + + +D D G N M ++ +LDRE + Y
Sbjct: 361 -GETVLA--VFSVSDLDSGDNGRVMCSIENNLPFFLKPSVENFYTLVSEGALDRETRSEY 417
Query: 862 KLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
+++ D G L ++ + +++ D NDN P F QI VR + L+
Sbjct: 418 NITITITDLGTPRLKTKYNITVLVSDVNDNAPAFTQISYTLFVRENNSPALH 469
Score = 48.8 bits (111), Expect = 1e-04
Identities = 36/119 (30%), Positives = 53/119 (44%), Gaps = 5/119 (4%)
Query: 1037 DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEIS 1096
DVNDH PVF + + + E+ V+ +A D D G+N+ Y I P+ S
Sbjct: 125 DVNDHSPVFFENEMHLKILESTLPGTVIPLGNAEDLDVGRNSLQNYTITPNSHFHVLTRS 184
Query: 1097 PLTG----VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
G L ++ LDRE + + LT+ A D G D+NDN+P+F
Sbjct: 185 RRDGRKYPELVLDKALDREEQPELSLTLTALDGG-SPPRSGTAQINIQVLDINDNAPEF 242
Score = 46.0 bits (104), Expect = 0.001
Identities = 68/244 (27%), Positives = 102/244 (41%), Gaps = 20/244 (8%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L + N+ V + D NDN P F + Y ++ N IG V A D D G N V Y
Sbjct: 430 RLKTKYNITVLVSDVNDNAPAFTQIS-YTLFVRENNSPALHIGSVSATDRDSGTNAQVTY 488
Query: 498 DL--QRTSNLTITSPFKINPNTGTVSVAESPILEGRHA--LFVEASDQ--PANPSERRYS 551
L + +L ++S IN + G + S E A V A+D+ PA SE
Sbjct: 489 SLLPPQDPHLPLSSLVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPALSSE---- 544
Query: 552 LAVVTIEVTRGTKGNKPDI--PDFMG-APYEFWVGSNVGIGTSVGQIRV--NDAFEQNDV 606
A+V + V N P + P G AP V G V ++ D+ + +
Sbjct: 545 -ALVRVLVL-DANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWL 602
Query: 607 SYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHV 666
SY LL E G+ F V +G + LS + + V +++N AT+HV
Sbjct: 603 SYQLLKATEPGL-FGVWAHNGEVRTARLLSERDAAKHRL-VVLVKDNGEPPRSATATLHV 660
Query: 667 VDVN 670
+ V+
Sbjct: 661 LLVD 664
Score = 39.5 bits (88), Expect = 0.091
Identities = 34/125 (27%), Positives = 58/125 (46%), Gaps = 5/125 (4%)
Query: 234 ELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVE 293
+++S +++ F L G L L ++LD + E +L Q L NPL+ E
Sbjct: 65 QVVSKGNKQHFQLSHQTGDLLLNEKLDRE-ELCGPTEPCILHFQIL-LQNPLQFVTN--E 120
Query: 294 IELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFS 353
+ ++D+ND+ P F + ++ I+E+ G + A D D G N Y + P F
Sbjct: 121 LRIIDVNDHSPVFFENEMHLKILESTLPGTVIPLGNAEDLDVGRNSLQNYTI-TPNSHFH 179
Query: 354 IDPRS 358
+ RS
Sbjct: 180 VLTRS 184
>AF152335-1|AAD43729.1| 930|Homo sapiens protocadherin gamma B6
protein.
Length = 930
Score = 111 bits (268), Expect = 1e-23
Identities = 121/477 (25%), Positives = 200/477 (41%), Gaps = 39/477 (8%)
Query: 432 IEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQ 491
+E E ++ +V V + D ND+ P F ++ + +A GT + A DPD+
Sbjct: 106 LEAVVENPLNIFHVIVVIEDVNDHAPQFDKKEIH-LEIFESASAGTRLSLDPATDPDINI 164
Query: 492 NGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR-----HALFVEASDQPANPS 546
N + Y + SN + ++N + G L R H+L + A D P
Sbjct: 165 NSIKDYKIN--SNPYFSLMVRVNSDGGKYPELSLEKLLDREEQRSHSLILTALDGGDPPR 222
Query: 547 ERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QN 604
A IE++ + P P F Y + N+ G+ V Q+ D E
Sbjct: 223 S-----ATAHIEISVKDTNDNP--PVFSRDEYRISLSENLPPGSPVLQVTATDQDEGVNA 275
Query: 605 DVSYDLLHGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNAT 663
+++Y + F+++E++G+I + Y E A ++ LS
Sbjct: 276 EINYYFRSTAQSTKHMFSLDEKTGMIKNNQSFDFEDVERYTMEVEA-KDGGGLSTQCKVI 334
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
+ ++D ND ++ + S I ENS + +F T GNG VR I +
Sbjct: 335 IEILDENDNSPEIIITSLSDQIL---ENSPPGMVVALFKTRDLDFGGNG--EVRCNI--E 387
Query: 724 QDVTDDIAIAEDG--TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
D+ I + + + T LDRE+ Y +T++A ++G + +T+Y+ D N
Sbjct: 388 TDIPFKIYSSSNNYYKLVTDGALDREQTPEYNVTIVAT-DRGKPPLSSSRSITLYVADIN 446
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDE 841
DN PVF+ +Y + EN+ G I + A+D D G N Y++ E V
Sbjct: 447 DNAPVFDQTSYVVHVAENNPPGASIAQ---VSASDPDLGLNGHISYSIVASDLEPLAVSS 503
Query: 842 NTGV-----VKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKP 891
V V F + D E+ + L+L ARD G LS+ L +++GD NDN P
Sbjct: 504 YVSVSAQSGVVFAQRAFDHEQLRAFALTLQARDHGSPTLSANVSLRVLVGDRNDNAP 560
Score = 94.3 bits (224), Expect = 3e-18
Identities = 99/344 (28%), Positives = 155/344 (45%), Gaps = 29/344 (8%)
Query: 574 MGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVD 633
+ P + + + G+ VG + + DVS L E + F+V+ SG + V +
Sbjct: 29 LSEPIRYSIPEELAKGSVVGNLAKDLGLSVLDVSARKLRVSAEKLHFSVDAESGDLLVKN 88
Query: 634 DLSRYN----RPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVK 689
+ R R + + A+ EN L+I + V + DVND K IF +
Sbjct: 89 RIDREQICKERRRCELQLEAVVENP-LNIF-HVIVVIEDVNDHAPQFDKKEIHLEIF--E 144
Query: 690 ENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDG----TIFTQKPLD 745
SAG + T+ I N + + I + + + + DG + +K LD
Sbjct: 145 SASAGTRLSLDPATD-PDININSIKDYK--INSNPYFSLMVRVNSDGGKYPELSLEKLLD 201
Query: 746 REKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTE 805
RE++ + + ++ + G + + I ++D NDNPPVF Y + EN G+
Sbjct: 202 REEQRSHSL-ILTALDGGDPPRSATAHIEISVKDTNDNPPVFSRDEYRISLSENLPPGSP 260
Query: 806 IKMDNIIKATDADEGTNALFMYTLFGEG---KEMFDVDENTGVVKFIGDSLDREKKIMYK 862
+ + ATD DEG NA Y K MF +DE TG++K S D E Y
Sbjct: 261 VLQ---VTATDQDEGVNAEINYYFRSTAQSTKHMFSLDEKTGMIKN-NQSFDFEDVERYT 316
Query: 863 LSLVARDTGGLSSEAELIIMIGDENDNKPEF------NQIEENS 900
+ + A+D GGLS++ ++II I DENDN PE +QI ENS
Sbjct: 317 MEVEAKDGGGLSTQCKVIIEILDENDNSPEIIITSLSDQILENS 360
Score = 82.2 bits (194), Expect = 1e-14
Identities = 62/217 (28%), Positives = 97/217 (44%), Gaps = 20/217 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN+P G+ ++++ A D D G+N +I Y F S A K F ++E+ G
Sbjct: 251 LSENLPPGSPVLQVTATDQDEGVNAEINYYFRS-----------TAQSTKHMFSLDEKTG 299
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ +S E + + + A DGG L+ V + + D ND+ P T + + E
Sbjct: 300 MIKNNQSFDFEDVERYTMEVEAKDGGGLSTQCKVIIEILDENDNSPEIIITSLSDQILEN 359
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
V+ D DFG N + I +TD+PF+I + L +G LDRE
Sbjct: 360 SPPGMVVALFKTRDLDFGGNGEVRCNI---ETDIPFKIYSSSNNYYKLVTDGALDREQTP 416
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
+Y +T+VA D G D+NDN+P F
Sbjct: 417 EYNVTIVATDRG-KPPLSSSRSITLYVADINDNAPVF 452
Score = 81.4 bits (192), Expect = 2e-14
Identities = 58/172 (33%), Positives = 87/172 (50%), Gaps = 11/172 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELD--LDAEHNLQANTFVLQVQ 277
A D D+ + + Y++ S L + +G + E L+ LD E ++++ +L
Sbjct: 157 ATDPDININSIKDYKINSNPYFSLMVRVNSDGGKYPELSLEKLLDREEQ-RSHSLILT-- 213
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A +P ++A A +EI + D NDN P F D Y IS+ ENLP G VLQV ATD+D+G
Sbjct: 214 ALDGGDPPRSATAHIEISVKDTNDNPPVFSRDEYRISLSENLPPGSPVLQVTATDQDEGV 273
Query: 338 NGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N E Y K FS+D ++G ++N D E M+V AK+
Sbjct: 274 NAEINYYFRSTAQSTKHMFSLDEKTG--MIKNNQSFDFEDVERYTMEVEAKD 323
Score = 77.0 bits (181), Expect = 5e-13
Identities = 77/300 (25%), Positives = 131/300 (43%), Gaps = 21/300 (7%)
Query: 858 KIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFT 917
+I Y A+ T + S E MI +N+ +F +E + ++ T
Sbjct: 276 EINYYFRSTAQSTKHMFSLDEKTGMI--KNNQSFDFEDVERYTMEVEAKDGGGLSTQCKV 333
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
IIE+ +N + ++ I EN P G + DLD G NG++R +++
Sbjct: 334 IIEILDENDNSPEIIITSLSDQILENSPPGMVVALFKTRDLDFGGNGEVRCNIETDI--- 390
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFV 1035
P K+ + + Y ++ + + R PE + + I A D G L+ + S+ ++V
Sbjct: 391 PFKIYSSSNNY--YKLVTDG----ALDREQTPE--YNVTIVATDRGKPPLSSSRSITLYV 442
Query: 1036 KDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTD----- 1090
D+ND+ PVF +T Y +V E + +V A+D D G N +++Y I SD +
Sbjct: 443 ADINDNAPVFDQTSYVVHVAENNPPGASIAQVSASDPDLGLNGHISYSIVASDLEPLAVS 502
Query: 1091 LPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
+S +GV+ D E + LT+ ARD+G D NDN+P+
Sbjct: 503 SYVSVSAQSGVVFAQRAFDHEQLRAFALTLQARDHG-SPTLSANVSLRVLVGDRNDNAPR 561
Score = 65.7 bits (153), Expect = 1e-09
Identities = 68/255 (26%), Positives = 109/255 (42%), Gaps = 21/255 (8%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
I+ ++ N A D+ I E+ GT + A D D +N Y+ NS Y
Sbjct: 120 IVVIEDVNDHAPQFDKKEIHLEIFESASAGTRLSLDPATDPDININSIKDYKINSNPYF- 178
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGGN--LNDNISVRV 1033
+L V R ++ + + + L E + L ++ALDGG+ + + +
Sbjct: 179 -------SLMV-RVNSDGGKYPELSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEI 230
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS--DTDL 1091
VKD ND+ PVF + Y ++ E + +V ATD D G NA + Y+ + + T
Sbjct: 231 SVKDTNDNPPVFSRDEYRISLSENLPPGSPVLQVTATDQDEGVNAEINYYFRSTAQSTKH 290
Query: 1092 PFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
F + TG++ N D E ++Y + V A+D G D NDNSP+
Sbjct: 291 MFSLDEKTGMIKNNQSFDFEDVERYTMEVEAKDGG---GLSTQCKVIIEILDENDNSPEI 347
Query: 1152 Y---AFDELLEWKHP 1163
D++LE P
Sbjct: 348 IITSLSDQILENSPP 362
Score = 64.1 bits (149), Expect = 4e-09
Identities = 66/207 (31%), Positives = 93/207 (44%), Gaps = 21/207 (10%)
Query: 932 DQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRY 991
DQ + + EN P G +I +++A D D GLNG I Y I S L + L V Y
Sbjct: 453 DQTSYVVHVAENNPPGASIAQVSASDPDLGLNGHISYS------IVASDL--EPLAVSSY 504
Query: 992 FVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDH-----F 1042
++ + G V R+ E F L + A D G+ L+ N+S+RV V D ND+ +
Sbjct: 505 VSVSAQSGVVFAQRAFDHEQLRAFALTLQARDHGSPTLSANVSLRVLVGDRNDNAPRVLY 564
Query: 1043 PVFKKTWYNF--NVEEAQYTRRVLGKVDATDADFGQNANLTYFI-QPSDTDLPFEISPLT 1099
P F V + ++ KV A DAD G NA L+Y + Q S+ L F + T
Sbjct: 565 PALGPDGSAFFDMVPRSAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGL-FSLGLRT 623
Query: 1100 GVLSVNGELDRETEDKYILTVVARDNG 1126
G + L + L V RD G
Sbjct: 624 GEVRTARALGDRDAARQRLLVAVRDGG 650
Score = 60.5 bits (140), Expect = 5e-08
Identities = 67/282 (23%), Positives = 117/282 (41%), Gaps = 27/282 (9%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRG 137
SA + + ++D NDN P+F Y +++ E P G + +
Sbjct: 223 SATAHIEISVKDTNDNPPVFSRDEYRISLSENLPPGSPVLQVTATDQDEGVNAEINYYFR 282
Query: 138 LTIFKDIRAFDRDKP-----NTPNSDVH----YSI-VSGNDDGHFALESSHKPVLLLRKV 187
T F D+ N + D Y++ V D G L + K ++ ++
Sbjct: 283 STAQSTKHMFSLDEKTGMIKNNQSFDFEDVERYTMEVEAKDGG--GLSTQCKVII---EI 337
Query: 188 LDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGATLRYELISGNDRKL 243
LD + D +++I + +I E P + A+ D D G +R + + K+
Sbjct: 338 LDEN--DNSPEIIITSLSDQI-LENSPPGMVVALFKTRDLDFGGNGEVRCNIETDIPFKI 394
Query: 244 FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNL 303
+S S N L + LD E + N ++ A+ P ++ + + + D+NDN
Sbjct: 395 YS--SSNNYYKLVTDGALDREQTPEYNVTIV---ATDRGKPPLSSSRSITLYVADINDNA 449
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
P F+ Y + + EN P G S+ QV A+D D G NG +Y +
Sbjct: 450 PVFDQTSYVVHVAENNPPGASIAQVSASDPDLGLNGHISYSI 491
Score = 60.1 bits (139), Expect = 6e-08
Identities = 55/206 (26%), Positives = 86/206 (41%), Gaps = 14/206 (6%)
Query: 218 IHAIDQDLGVGATLRYELISG--NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A DQD GV A + Y S + + +FSLD G + + D + + ++
Sbjct: 264 VTATDQDEGVNAEINYYFRSTAQSTKHMFSLDEKTGMIKNNQSFDFE-----DVERYTME 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
V+A L T Q +V IE+LD NDN PE + + I+EN P G V D D
Sbjct: 319 VEAKD-GGGLST-QCKVIIEILDENDNSPEIIITSLSDQILENSPPGMVVALFKTRDLDF 376
Query: 336 GENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGTFA 395
G NGE ++ + + + LDRE + + A + +
Sbjct: 377 GGNGEVRCNIETDIPFKIYSSSNNYYKLVTDGALDREQTPEYNVTIVATDRGKPPL---- 432
Query: 396 DSQRIAKWRRQPLETNAPL-EKTTYV 420
S R + NAP+ ++T+YV
Sbjct: 433 SSSRSITLYVADINDNAPVFDQTSYV 458
Score = 50.4 bits (115), Expect = 5e-05
Identities = 89/371 (23%), Positives = 148/371 (39%), Gaps = 52/371 (14%)
Query: 37 AQSIDSLVDSDSPQNVVKFRLGCDFDEGDDLV-----RIGAGLNQISAYLSVTVYIEDVN 91
AQS + D ++K DF++ + + G GL S V + I D N
Sbjct: 285 AQSTKHMFSLDEKTGMIKNNQSFDFEDVERYTMEVEAKDGGGL---STQCKVIIEILDEN 341
Query: 92 DNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIG------PSLTIPLTVPRGL-----TI 140
DN P + T + E +P G +F + I +P +
Sbjct: 342 DNSPEIIITSLSDQILENSPPGMVVALFKTRDLDFGGNGEVRCNIETDIPFKIYSSSNNY 401
Query: 141 FKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDY-DAGDKEFQL 199
+K + D+ TP +V +IV+ D G L SS L + + D D+ +
Sbjct: 402 YKLVTDGALDREQTPEYNV--TIVA-TDRGKPPLSSSRSITLYVADINDNAPVFDQTSYV 458
Query: 200 VIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKL-----FSLDSVNGSLF 254
V +A I + A D DLG+ + Y +++ + L S+ + +G +F
Sbjct: 459 VHVAENNPPGASIA---QVSASDPDLGLNGHISYSIVASDLEPLAVSSYVSVSAQSGVVF 515
Query: 255 LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD----- 309
++ D + Q F L +QA +P +A + + + D NDN P
Sbjct: 516 AQRAFDHE-----QLRAFALTLQARDHGSPTLSANVSLRVLVGDRNDNAPRVLYPALGPD 570
Query: 310 ---FYNISIVENLPNGFSVLQVMATDKDQGENGEFTY---QLDDPKGAFSIDPRSGWLTV 363
F+++ + + G+ V +V+A D D G N +Y Q +P G FS+ R+G V
Sbjct: 571 GSAFFDM-VPRSAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEP-GLFSLGLRTG--EV 626
Query: 364 RNQTVL-DREA 373
R L DR+A
Sbjct: 627 RTARALGDRDA 637
Score = 41.9 bits (94), Expect = 0.017
Identities = 46/173 (26%), Positives = 67/173 (38%), Gaps = 12/173 (6%)
Query: 989 KRYFVINERHGHVIVARSLPPES------EFRLNISALDGGNLNDNISVRVFVKDVNDHF 1042
K +F ++ G ++V + E L + A+ LN V V ++DVNDH
Sbjct: 72 KLHFSVDAESGDLLVKNRIDREQICKERRRCELQLEAVVENPLNI-FHVIVVIEDVNDHA 130
Query: 1043 PVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD-TDLPFEISPLTG- 1100
P F K + + E+ L ATD D N+ Y I + L ++ G
Sbjct: 131 PQFDKKEIHLEIFESASAGTRLSLDPATDPDININSIKDYKINSNPYFSLMVRVNSDGGK 190
Query: 1101 --VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
LS+ LDRE + + L + A D G D NDN P F
Sbjct: 191 YPELSLEKLLDREEQRSHSLILTALDGG-DPPRSATAHIEISVKDTNDNPPVF 242
Score = 38.3 bits (85), Expect = 0.21
Identities = 29/103 (28%), Positives = 52/103 (50%), Gaps = 4/103 (3%)
Query: 244 FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNL 303
FS+D+ +G L ++ +D + + + LQ++A + NPL V IE D+ND+
Sbjct: 75 FSVDAESGDLLVKNRIDRE-QICKERRRCELQLEAV-VENPLNIFHVIVVIE--DVNDHA 130
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
P+F+ ++ I E+ G + ATD D N Y+++
Sbjct: 131 PQFDKKEIHLEIFESASAGTRLSLDPATDPDININSIKDYKIN 173
>AF152485-1|AAD43746.1| 789|Homo sapiens protocadherin alpha 7 short
form protein protein.
Length = 789
Score = 111 bits (267), Expect = 2e-23
Identities = 119/425 (28%), Positives = 175/425 (41%), Gaps = 56/425 (13%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
++G +F +DRE+ V ++ V + ++D NDNPPVF
Sbjct: 80 QNGILFVNSRIDREELCGRSAECSIHLEVIVERPLQVFHVDVEVKDINDNPPVFPATQRN 139
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
FI E+ + + ++ A+DAD G NAL Y L DV + VK +G
Sbjct: 140 LFIAESRPLDSRFPLEG---ASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLG--- 193
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
LV R EL +++ + KPE L GT
Sbjct: 194 -----------LVLRKLLDREETPELHLLLTATDGGKPE-----------------LTGT 225
Query: 914 AGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
+I V N A D+ +PEN+ IGT +I NA DLD GLNG I Y F+S+
Sbjct: 226 VQL-LITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSD 284
Query: 974 VYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNI 1029
V + ++K F ++ G + V + E ++ + A+D G L +
Sbjct: 285 V----------SPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHC 334
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
+V V V DVND+ P T + + E V+ + D DFG N +T + P
Sbjct: 335 TVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPR-- 392
Query: 1090 DLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+PF+ +S S ++ LDRE+ Y L V ARD G DVND
Sbjct: 393 -VPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGG-SPSLWATASVSVEVADVND 450
Query: 1147 NSPKF 1151
N+P F
Sbjct: 451 NAPAF 455
Score = 83.0 bits (196), Expect = 7e-15
Identities = 110/464 (23%), Positives = 191/464 (41%), Gaps = 35/464 (7%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + +T+LD NDN PVF LY + N +GT++ A D D G NG ++Y
Sbjct: 221 ELTGTVQLLITVLDNNDNAPVF-DRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIY 279
Query: 498 DLQRTSNLTITSPFKINPNTGTVSV-AESPILEGR-HALFVEASDQPANPSERRYSLAVV 555
+ I S F ++P +G ++V E R H + VEA D+ P ++ V
Sbjct: 280 SFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVE 339
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
++V + P + + GT + I V D V+ +
Sbjct: 340 VVDVN-------DNAPQLTLTSLSLPIPEDAQPGTVITLISVFD--RDFGVNGQVTCSLT 390
Query: 616 EGVPFAVEE--RSGVITVVDD-LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVND 671
VPF + ++ V+D L R + Y+ A + +L + +V V DVND
Sbjct: 391 PRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVND 450
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRF----LIANQQDVT 727
+ ++ +F VKEN+ IF + V + L ++ ++
Sbjct: 451 NAPAFAQPEYT--VF-VKENNPPGC--HIFTVSAGDADAQKNALVSYSLVELRVGERALS 505
Query: 728 DDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
+++ AE G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 506 SYVSVHAESGKVYALQPLDHEELELLQFQVSAR-DAGVPPLGSNVTLQVFVLDENDNAPA 564
Query: 787 FEHATYEGF-IMENSKIGTEIKMDNI---IKATDADEGTNALFMYTL--FGEGKEM-FDV 839
G + + ++ ++A DAD G NA Y L G + F V
Sbjct: 565 LLAPRVGGTGGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPVAAGASIPFRV 624
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMI 883
TG + +LD ++L ++ +D G S A +++
Sbjct: 625 GLYTGEIS-TTRALDETDAPRHRLLVLVKDHGEPSLTATATVLV 667
Score = 79.8 bits (188), Expect = 7e-14
Identities = 113/478 (23%), Positives = 178/478 (37%), Gaps = 36/478 (7%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E E+ + +V+V + D NDN PVF P+ + + + + A D D+G
Sbjct: 105 HLEVIVERPLQVFHVDVEVKDINDNPPVF-PATQRNLFIAESRPLDSRFPLEGASDADIG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHA----LFVEASDQPANPS 546
+N ++ Y L + P N + + +L+ L + A+D
Sbjct: 164 ENALLTYRLSPNEYFFLDVPTS-NQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPEL 222
Query: 547 ERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QN 604
L + ++ N + P F Y + NV IGT V +D E
Sbjct: 223 TGTVQLLITVLD-------NNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNG 275
Query: 605 DVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQEN-ANLSIVTN 661
D+ Y + F ++ SG ITV+ + + A+ + L+
Sbjct: 276 DIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCT 335
Query: 662 ATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIA 721
V VVDVND L + S I + + +F + G V +
Sbjct: 336 VLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGV-----NGQVTCSLT 390
Query: 722 NQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
+ ++ LDRE Y + V A + G S V++ + D N
Sbjct: 391 PRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTAR-DGGSPSLWATASVSVEVADVN 449
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEG--KE 835
DN P F Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 450 DNAPAFAQPEYTVFVKENNPPGCHI---FTVSAGDADAQKNALVSYSLVELRVGERALSS 506
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 507 YVSVHAESGKV-YALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAP 563
Score = 64.1 bits (149), Expect = 4e-09
Identities = 62/221 (28%), Positives = 94/221 (42%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y E+ +
Sbjct: 443 VEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNALVSYSL-VELRVGE 501
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVF 1034
LS+ Y ++ G V + L E + +SA D G L N++++VF
Sbjct: 502 RALSS-------YVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVF 554
Query: 1035 VKDVNDHFPVFKKTWYNFN-------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQP- 1086
V D ND+ P V + V+ KV A DAD G NA L+Y +QP
Sbjct: 555 VLDENDNAPALLAPRVGGTGGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPV 614
Query: 1087 -SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+ +PF + TG +S LD ++ L V+ +D+G
Sbjct: 615 AAGASIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHG 655
Score = 62.5 bits (145), Expect = 1e-08
Identities = 82/345 (23%), Positives = 150/345 (43%), Gaps = 43/345 (12%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPT--------------GEKAFIFLIAPIGPSL 128
V V ++D+NDN P+F T ++ + E P GE A L + P+
Sbjct: 119 VDVEVKDINDNPPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENAL--LTYRLSPNE 176
Query: 129 TIPLTVPRGLTIFKDIRAFDR---DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR 185
L VP K + R D+ TP ++H +++ D G L + V LL
Sbjct: 177 YFFLDVPTSNQQVKPLGLVLRKLLDREETP--ELHL-LLTATDGGKPELTGT---VQLLI 230
Query: 186 KVLDYDAG----DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL---ISG 238
VLD + D+ V + I ++ P +A D D G+ + Y +S
Sbjct: 231 TVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHP---NASDLDEGLNGDIIYSFSSDVSP 287
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
+ + F +D ++G++ + +D + ++ + V+A P V +E++D
Sbjct: 288 DIKSKFHMDPLSGAITVIGHMDFE-----ESRAHKIPVEAVDKGFPPLAGHCTVLVEVVD 342
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFS-IDPR 357
+NDN P+ + ++ I E+ G + + D+D G NG+ T L P+ F +
Sbjct: 343 VNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSL-TPRVPFKLVSTF 401
Query: 358 SGWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGTFADSQRIA 401
+ ++ + LDRE+ S+ + V A++ +PS+ T + S +A
Sbjct: 402 KNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVA 446
Score = 56.4 bits (130), Expect = 7e-07
Identities = 40/128 (31%), Positives = 56/128 (43%), Gaps = 5/128 (3%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D+D GV + L KL S SL L+ LD ++ + + L V
Sbjct: 372 ISVFDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLVLDSALDRES-----VSAYELVVT 426
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A +P A A V +E+ D+NDN P F Y + + EN P G + V A D D +
Sbjct: 427 ARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQK 486
Query: 338 NGEFTYQL 345
N +Y L
Sbjct: 487 NALVSYSL 494
Score = 54.0 bits (124), Expect = 4e-06
Identities = 72/249 (28%), Positives = 103/249 (41%), Gaps = 31/249 (12%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
++EV N A + IPE+ GT I ++ D D G+NGQ+ V
Sbjct: 337 LVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPRV--- 393
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRV 1033
P KL + K Y+ + ++ +L ES + L ++A DGG+ L SV V
Sbjct: 394 PFKLVST---FKNYYSL-------VLDSALDRESVSAYELVVTARDGGSPSLWATASVSV 443
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPF 1093
V DVND+ P F + Y V+E + V A DAD +NA ++Y S +L
Sbjct: 444 EVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNALVSY----SLVELRV 499
Query: 1094 EISPLTGVLSVNGE---------LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDV 1144
L+ +SV+ E LD E + V ARD G D
Sbjct: 500 GERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAG-VPPLGSNVTLQVFVLDE 558
Query: 1145 NDNSPKFYA 1153
NDN+P A
Sbjct: 559 NDNAPALLA 567
Score = 49.6 bits (113), Expect = 8e-05
Identities = 55/205 (26%), Positives = 85/205 (41%), Gaps = 13/205 (6%)
Query: 700 IFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAE-----DGTIFTQKPLDREKRDVYRM 754
+ H N S + G++ + ++ DV+ DI G I +D E+ +++
Sbjct: 261 VIHPNASDLDEGLNGDIIYSFSS--DVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKI 318
Query: 755 TVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKA 814
V A +KG AG V + + D NDN P + I E+++ GT I +I
Sbjct: 319 PVEA-VDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVI---TLISV 374
Query: 815 TDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--G 872
D D G N +L + +LDRE Y+L + ARD G
Sbjct: 375 FDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPS 434
Query: 873 LSSEAELIIMIGDENDNKPEFNQIE 897
L + A + + + D NDN P F Q E
Sbjct: 435 LWATASVSVEVADVNDNAPAFAQPE 459
Score = 46.0 bits (104), Expect = 0.001
Identities = 47/158 (29%), Positives = 72/158 (45%), Gaps = 13/158 (8%)
Query: 243 LFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQVQASQLNNPLKTAQARVEIELLDLND 301
L ++ NG LF+ +D + A + L+V + PL+ V++E+ D+ND
Sbjct: 74 LLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVER---PLQVFH--VDVEVKDIND 128
Query: 302 NLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSID-PRSGW 360
N P F N+ I E+ P A+D D GEN TY+L P F +D P S
Sbjct: 129 NPPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRL-SPNEYFFLDVPTSNQ 187
Query: 361 ----LTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
L + + +LDRE L + + A + P + GT
Sbjct: 188 QVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGT 225
Score = 44.0 bits (99), Expect = 0.004
Identities = 41/156 (26%), Positives = 72/156 (46%), Gaps = 24/156 (15%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++TV D D + PVF Y +++ ENV+ ++ N ++ E
Sbjct: 218 GKPELTGTVQLLITVLDNND-----NAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
N + Y ++ DI+ F +DP +G + ++ D E +++ V A + +
Sbjct: 273 LNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFP---- 328
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
P+A V+V + DVNDN+P+ T
Sbjct: 329 ----PLAG---------HCTVLVEVVDVNDNAPQLT 351
Score = 43.2 bits (97), Expect = 0.007
Identities = 37/127 (29%), Positives = 57/127 (44%), Gaps = 10/127 (7%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNL------YEFSMKSNAKVGTVIGKVKAVDPDLGQN 492
L S V ++V +LD NDN P + + + + G V+ KV+AVD D G N
Sbjct: 545 LGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVRELVPRSVGAGHVVAKVRAVDADSGYN 604
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSV--AESPILEGRHALFVEASDQPANPSERRY 550
+ Y+LQ + + PF++ TG +S A RH L V D PS
Sbjct: 605 AWLSYELQPVA-AGASIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDH-GEPSLTAT 662
Query: 551 SLAVVTI 557
+ +V++
Sbjct: 663 ATVLVSL 669
Score = 42.7 bits (96), Expect = 0.010
Identities = 82/347 (23%), Positives = 132/347 (38%), Gaps = 30/347 (8%)
Query: 70 IGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP----IG 125
+ G ++ + +V V + DVNDN P T + + E G + + +
Sbjct: 323 VDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVN 382
Query: 126 PSLTIPLT--VPRGL-TIFKDIRAFDRDKPNTPNSDVHYS-IVSGNDDGHFALESSHKPV 181
+T LT VP L + FK+ + D S Y +V+ D G +L ++
Sbjct: 383 GQVTCSLTPRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVS 442
Query: 182 LLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELIS--GN 239
+ + V D + + + +F + A D D A + Y L+
Sbjct: 443 VEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFT--VSAGDADAQKNALVSYSLVELRVG 500
Query: 240 DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
+R L S SV+ G ++ + LD + LQ QV A P + +++ +
Sbjct: 501 ERALSSYVSVHAESGKVYALQPLDHEELELLQ-----FQVSARDAGVPPLGSNVTLQVFV 555
Query: 297 LDLNDNLPEF---EVDFYNISIVENLPN----GFSVLQVMATDKDQGENGEFTYQLDDPK 349
LD NDN P V ++ E +P G V +V A D D G N +Y+L
Sbjct: 556 LDENDNAPALLAPRVGGTGGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPVA 615
Query: 350 GAFSIDPRSGWLT--VRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
SI R G T + LD R+ V K+ PS+ T
Sbjct: 616 AGASIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPSLTAT 662
Score = 36.3 bits (80), Expect = 0.85
Identities = 20/62 (32%), Positives = 34/62 (54%), Gaps = 5/62 (8%)
Query: 1429 ERLSLNGLT-SPQATDSDIGINADIRYQILNEQAP----RFAIDPVSGTVRVVAALARDA 1483
E +S+ L P A+D D G+N DI Y ++ +P +F +DP+SG + V+ + +
Sbjct: 253 ENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEE 312
Query: 1484 GR 1485
R
Sbjct: 313 SR 314
>AF152315-1|AAD43709.1| 937|Homo sapiens protocadherin alpha 7
protein.
Length = 937
Score = 111 bits (267), Expect = 2e-23
Identities = 119/425 (28%), Positives = 175/425 (41%), Gaps = 56/425 (13%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
++G +F +DRE+ V ++ V + ++D NDNPPVF
Sbjct: 80 QNGILFVNSRIDREELCGRSAECSIHLEVIVERPLQVFHVDVEVKDINDNPPVFPATQRN 139
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
FI E+ + + ++ A+DAD G NAL Y L DV + VK +G
Sbjct: 140 LFIAESRPLDSRFPLEG---ASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLG--- 193
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
LV R EL +++ + KPE L GT
Sbjct: 194 -----------LVLRKLLDREETPELHLLLTATDGGKPE-----------------LTGT 225
Query: 914 AGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
+I V N A D+ +PEN+ IGT +I NA DLD GLNG I Y F+S+
Sbjct: 226 VQL-LITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSD 284
Query: 974 VYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNI 1029
V + ++K F ++ G + V + E ++ + A+D G L +
Sbjct: 285 V----------SPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHC 334
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
+V V V DVND+ P T + + E V+ + D DFG N +T + P
Sbjct: 335 TVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPR-- 392
Query: 1090 DLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+PF+ +S S ++ LDRE+ Y L V ARD G DVND
Sbjct: 393 -VPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGG-SPSLWATASVSVEVADVND 450
Query: 1147 NSPKF 1151
N+P F
Sbjct: 451 NAPAF 455
Score = 83.0 bits (196), Expect = 7e-15
Identities = 110/464 (23%), Positives = 191/464 (41%), Gaps = 35/464 (7%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + +T+LD NDN PVF LY + N +GT++ A D D G NG ++Y
Sbjct: 221 ELTGTVQLLITVLDNNDNAPVF-DRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIY 279
Query: 498 DLQRTSNLTITSPFKINPNTGTVSV-AESPILEGR-HALFVEASDQPANPSERRYSLAVV 555
+ I S F ++P +G ++V E R H + VEA D+ P ++ V
Sbjct: 280 SFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVE 339
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
++V + P + + GT + I V D V+ +
Sbjct: 340 VVDVN-------DNAPQLTLTSLSLPIPEDAQPGTVITLISVFD--RDFGVNGQVTCSLT 390
Query: 616 EGVPFAVEE--RSGVITVVDD-LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVND 671
VPF + ++ V+D L R + Y+ A + +L + +V V DVND
Sbjct: 391 PRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVND 450
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRF----LIANQQDVT 727
+ ++ +F VKEN+ IF + V + L ++ ++
Sbjct: 451 NAPAFAQPEYT--VF-VKENNPPGC--HIFTVSAGDADAQKNALVSYSLVELRVGERALS 505
Query: 728 DDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
+++ AE G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 506 SYVSVHAESGKVYALQPLDHEELELLQFQVSAR-DAGVPPLGSNVTLQVFVLDENDNAPA 564
Query: 787 FEHATYEGF-IMENSKIGTEIKMDNI---IKATDADEGTNALFMYTL--FGEGKEM-FDV 839
G + + ++ ++A DAD G NA Y L G + F V
Sbjct: 565 LLAPRVGGTGGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPVAAGASIPFRV 624
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMI 883
TG + +LD ++L ++ +D G S A +++
Sbjct: 625 GLYTGEIS-TTRALDETDAPRHRLLVLVKDHGEPSLTATATVLV 667
Score = 79.8 bits (188), Expect = 7e-14
Identities = 113/478 (23%), Positives = 178/478 (37%), Gaps = 36/478 (7%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E E+ + +V+V + D NDN PVF P+ + + + + A D D+G
Sbjct: 105 HLEVIVERPLQVFHVDVEVKDINDNPPVF-PATQRNLFIAESRPLDSRFPLEGASDADIG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHA----LFVEASDQPANPS 546
+N ++ Y L + P N + + +L+ L + A+D
Sbjct: 164 ENALLTYRLSPNEYFFLDVPTS-NQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPEL 222
Query: 547 ERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QN 604
L + ++ N + P F Y + NV IGT V +D E
Sbjct: 223 TGTVQLLITVLD-------NNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNG 275
Query: 605 DVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQEN-ANLSIVTN 661
D+ Y + F ++ SG ITV+ + + A+ + L+
Sbjct: 276 DIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCT 335
Query: 662 ATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIA 721
V VVDVND L + S I + + +F + G V +
Sbjct: 336 VLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGV-----NGQVTCSLT 390
Query: 722 NQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
+ ++ LDRE Y + V A + G S V++ + D N
Sbjct: 391 PRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTAR-DGGSPSLWATASVSVEVADVN 449
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEG--KE 835
DN P F Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 450 DNAPAFAQPEYTVFVKENNPPGCHI---FTVSAGDADAQKNALVSYSLVELRVGERALSS 506
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 507 YVSVHAESGKV-YALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAP 563
Score = 64.1 bits (149), Expect = 4e-09
Identities = 62/221 (28%), Positives = 94/221 (42%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y E+ +
Sbjct: 443 VEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNALVSYSL-VELRVGE 501
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVF 1034
LS+ Y ++ G V + L E + +SA D G L N++++VF
Sbjct: 502 RALSS-------YVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVF 554
Query: 1035 VKDVNDHFPVFKKTWYNFN-------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQP- 1086
V D ND+ P V + V+ KV A DAD G NA L+Y +QP
Sbjct: 555 VLDENDNAPALLAPRVGGTGGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPV 614
Query: 1087 -SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+ +PF + TG +S LD ++ L V+ +D+G
Sbjct: 615 AAGASIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHG 655
Score = 62.5 bits (145), Expect = 1e-08
Identities = 82/345 (23%), Positives = 150/345 (43%), Gaps = 43/345 (12%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPT--------------GEKAFIFLIAPIGPSL 128
V V ++D+NDN P+F T ++ + E P GE A L + P+
Sbjct: 119 VDVEVKDINDNPPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENAL--LTYRLSPNE 176
Query: 129 TIPLTVPRGLTIFKDIRAFDR---DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR 185
L VP K + R D+ TP ++H +++ D G L + V LL
Sbjct: 177 YFFLDVPTSNQQVKPLGLVLRKLLDREETP--ELHL-LLTATDGGKPELTGT---VQLLI 230
Query: 186 KVLDYDAG----DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL---ISG 238
VLD + D+ V + I ++ P +A D D G+ + Y +S
Sbjct: 231 TVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHP---NASDLDEGLNGDIIYSFSSDVSP 287
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
+ + F +D ++G++ + +D + ++ + V+A P V +E++D
Sbjct: 288 DIKSKFHMDPLSGAITVIGHMDFE-----ESRAHKIPVEAVDKGFPPLAGHCTVLVEVVD 342
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFS-IDPR 357
+NDN P+ + ++ I E+ G + + D+D G NG+ T L P+ F +
Sbjct: 343 VNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSL-TPRVPFKLVSTF 401
Query: 358 SGWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGTFADSQRIA 401
+ ++ + LDRE+ S+ + V A++ +PS+ T + S +A
Sbjct: 402 KNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVA 446
Score = 56.4 bits (130), Expect = 7e-07
Identities = 40/128 (31%), Positives = 56/128 (43%), Gaps = 5/128 (3%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D+D GV + L KL S SL L+ LD ++ + + L V
Sbjct: 372 ISVFDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLVLDSALDRES-----VSAYELVVT 426
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A +P A A V +E+ D+NDN P F Y + + EN P G + V A D D +
Sbjct: 427 ARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQK 486
Query: 338 NGEFTYQL 345
N +Y L
Sbjct: 487 NALVSYSL 494
Score = 54.0 bits (124), Expect = 4e-06
Identities = 72/249 (28%), Positives = 103/249 (41%), Gaps = 31/249 (12%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
++EV N A + IPE+ GT I ++ D D G+NGQ+ V
Sbjct: 337 LVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPRV--- 393
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRV 1033
P KL + K Y+ + ++ +L ES + L ++A DGG+ L SV V
Sbjct: 394 PFKLVST---FKNYYSL-------VLDSALDRESVSAYELVVTARDGGSPSLWATASVSV 443
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPF 1093
V DVND+ P F + Y V+E + V A DAD +NA ++Y S +L
Sbjct: 444 EVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNALVSY----SLVELRV 499
Query: 1094 EISPLTGVLSVNGE---------LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDV 1144
L+ +SV+ E LD E + V ARD G D
Sbjct: 500 GERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAG-VPPLGSNVTLQVFVLDE 558
Query: 1145 NDNSPKFYA 1153
NDN+P A
Sbjct: 559 NDNAPALLA 567
Score = 49.6 bits (113), Expect = 8e-05
Identities = 55/205 (26%), Positives = 85/205 (41%), Gaps = 13/205 (6%)
Query: 700 IFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAE-----DGTIFTQKPLDREKRDVYRM 754
+ H N S + G++ + ++ DV+ DI G I +D E+ +++
Sbjct: 261 VIHPNASDLDEGLNGDIIYSFSS--DVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKI 318
Query: 755 TVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKA 814
V A +KG AG V + + D NDN P + I E+++ GT I +I
Sbjct: 319 PVEA-VDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVI---TLISV 374
Query: 815 TDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--G 872
D D G N +L + +LDRE Y+L + ARD G
Sbjct: 375 FDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPS 434
Query: 873 LSSEAELIIMIGDENDNKPEFNQIE 897
L + A + + + D NDN P F Q E
Sbjct: 435 LWATASVSVEVADVNDNAPAFAQPE 459
Score = 46.0 bits (104), Expect = 0.001
Identities = 47/158 (29%), Positives = 72/158 (45%), Gaps = 13/158 (8%)
Query: 243 LFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQVQASQLNNPLKTAQARVEIELLDLND 301
L ++ NG LF+ +D + A + L+V + PL+ V++E+ D+ND
Sbjct: 74 LLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVER---PLQVFH--VDVEVKDIND 128
Query: 302 NLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSID-PRSGW 360
N P F N+ I E+ P A+D D GEN TY+L P F +D P S
Sbjct: 129 NPPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRL-SPNEYFFLDVPTSNQ 187
Query: 361 ----LTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
L + + +LDRE L + + A + P + GT
Sbjct: 188 QVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGT 225
Score = 44.0 bits (99), Expect = 0.004
Identities = 41/156 (26%), Positives = 72/156 (46%), Gaps = 24/156 (15%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++TV D D + PVF Y +++ ENV+ ++ N ++ E
Sbjct: 218 GKPELTGTVQLLITVLDNND-----NAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
N + Y ++ DI+ F +DP +G + ++ D E +++ V A + +
Sbjct: 273 LNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFP---- 328
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
P+A V+V + DVNDN+P+ T
Sbjct: 329 ----PLAG---------HCTVLVEVVDVNDNAPQLT 351
Score = 43.2 bits (97), Expect = 0.007
Identities = 37/127 (29%), Positives = 57/127 (44%), Gaps = 10/127 (7%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNL------YEFSMKSNAKVGTVIGKVKAVDPDLGQN 492
L S V ++V +LD NDN P + + + + G V+ KV+AVD D G N
Sbjct: 545 LGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVRELVPRSVGAGHVVAKVRAVDADSGYN 604
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSV--AESPILEGRHALFVEASDQPANPSERRY 550
+ Y+LQ + + PF++ TG +S A RH L V D PS
Sbjct: 605 AWLSYELQPVA-AGASIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDH-GEPSLTAT 662
Query: 551 SLAVVTI 557
+ +V++
Sbjct: 663 ATVLVSL 669
Score = 42.7 bits (96), Expect = 0.010
Identities = 82/347 (23%), Positives = 132/347 (38%), Gaps = 30/347 (8%)
Query: 70 IGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP----IG 125
+ G ++ + +V V + DVNDN P T + + E G + + +
Sbjct: 323 VDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVN 382
Query: 126 PSLTIPLT--VPRGL-TIFKDIRAFDRDKPNTPNSDVHYS-IVSGNDDGHFALESSHKPV 181
+T LT VP L + FK+ + D S Y +V+ D G +L ++
Sbjct: 383 GQVTCSLTPRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVS 442
Query: 182 LLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELIS--GN 239
+ + V D + + + +F + A D D A + Y L+
Sbjct: 443 VEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFT--VSAGDADAQKNALVSYSLVELRVG 500
Query: 240 DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
+R L S SV+ G ++ + LD + LQ QV A P + +++ +
Sbjct: 501 ERALSSYVSVHAESGKVYALQPLDHEELELLQ-----FQVSARDAGVPPLGSNVTLQVFV 555
Query: 297 LDLNDNLPEF---EVDFYNISIVENLPN----GFSVLQVMATDKDQGENGEFTYQLDDPK 349
LD NDN P V ++ E +P G V +V A D D G N +Y+L
Sbjct: 556 LDENDNAPALLAPRVGGTGGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPVA 615
Query: 350 GAFSIDPRSGWLT--VRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
SI R G T + LD R+ V K+ PS+ T
Sbjct: 616 AGASIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPSLTAT 662
Score = 36.3 bits (80), Expect = 0.85
Identities = 20/62 (32%), Positives = 34/62 (54%), Gaps = 5/62 (8%)
Query: 1429 ERLSLNGLT-SPQATDSDIGINADIRYQILNEQAP----RFAIDPVSGTVRVVAALARDA 1483
E +S+ L P A+D D G+N DI Y ++ +P +F +DP+SG + V+ + +
Sbjct: 253 ENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEE 312
Query: 1484 GR 1485
R
Sbjct: 313 SR 314
>AC005609-7|AAC34319.1| 789|Homo sapiens KIAA0345-like 7 protein.
Length = 789
Score = 111 bits (267), Expect = 2e-23
Identities = 119/425 (28%), Positives = 175/425 (41%), Gaps = 56/425 (13%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
++G +F +DRE+ V ++ V + ++D NDNPPVF
Sbjct: 80 QNGILFVNSRIDREELCGRSAECSIHLEVIVERPLQVFHVDVEVKDINDNPPVFPATQRN 139
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
FI E+ + + ++ A+DAD G NAL Y L DV + VK +G
Sbjct: 140 LFIAESRPLDSRFPLEG---ASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLG--- 193
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
LV R EL +++ + KPE L GT
Sbjct: 194 -----------LVLRKLLDREETPELHLLLTATDGGKPE-----------------LTGT 225
Query: 914 AGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
+I V N A D+ +PEN+ IGT +I NA DLD GLNG I Y F+S+
Sbjct: 226 VQL-LITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSD 284
Query: 974 VYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNI 1029
V + ++K F ++ G + V + E ++ + A+D G L +
Sbjct: 285 V----------SPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHC 334
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
+V V V DVND+ P T + + E V+ + D DFG N +T + P
Sbjct: 335 TVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPR-- 392
Query: 1090 DLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+PF+ +S S ++ LDRE+ Y L V ARD G DVND
Sbjct: 393 -VPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGG-SPSLWATASVSVEVADVND 450
Query: 1147 NSPKF 1151
N+P F
Sbjct: 451 NAPAF 455
Score = 83.0 bits (196), Expect = 7e-15
Identities = 110/464 (23%), Positives = 191/464 (41%), Gaps = 35/464 (7%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + +T+LD NDN PVF LY + N +GT++ A D D G NG ++Y
Sbjct: 221 ELTGTVQLLITVLDNNDNAPVF-DRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIY 279
Query: 498 DLQRTSNLTITSPFKINPNTGTVSV-AESPILEGR-HALFVEASDQPANPSERRYSLAVV 555
+ I S F ++P +G ++V E R H + VEA D+ P ++ V
Sbjct: 280 SFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVE 339
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
++V + P + + GT + I V D V+ +
Sbjct: 340 VVDVN-------DNAPQLTLTSLSLPIPEDAQPGTVITLISVFD--RDFGVNGQVTCSLT 390
Query: 616 EGVPFAVEE--RSGVITVVDD-LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVND 671
VPF + ++ V+D L R + Y+ A + +L + +V V DVND
Sbjct: 391 PRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVND 450
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRF----LIANQQDVT 727
+ ++ +F VKEN+ IF + V + L ++ ++
Sbjct: 451 NAPAFAQPEYT--VF-VKENNPPGC--HIFTVSAGDADAQKNALVSYSLVELRVGERALS 505
Query: 728 DDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
+++ AE G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 506 SYVSVHAESGKVYALQPLDHEELELLQFQVSAR-DAGVPPLGSNVTLQVFVLDENDNAPA 564
Query: 787 FEHATYEGF-IMENSKIGTEIKMDNI---IKATDADEGTNALFMYTL--FGEGKEM-FDV 839
G + + ++ ++A DAD G NA Y L G + F V
Sbjct: 565 LLAPRVGGTGGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPVAAGASIPFRV 624
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMI 883
TG + +LD ++L ++ +D G S A +++
Sbjct: 625 GLYTGEIS-TTRALDETDAPRHRLLVLVKDHGEPSLTATATVLV 667
Score = 79.8 bits (188), Expect = 7e-14
Identities = 113/478 (23%), Positives = 178/478 (37%), Gaps = 36/478 (7%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E E+ + +V+V + D NDN PVF P+ + + + + A D D+G
Sbjct: 105 HLEVIVERPLQVFHVDVEVKDINDNPPVF-PATQRNLFIAESRPLDSRFPLEGASDADIG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHA----LFVEASDQPANPS 546
+N ++ Y L + P N + + +L+ L + A+D
Sbjct: 164 ENALLTYRLSPNEYFFLDVPTS-NQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPEL 222
Query: 547 ERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QN 604
L + ++ N + P F Y + NV IGT V +D E
Sbjct: 223 TGTVQLLITVLD-------NNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNG 275
Query: 605 DVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQEN-ANLSIVTN 661
D+ Y + F ++ SG ITV+ + + A+ + L+
Sbjct: 276 DIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCT 335
Query: 662 ATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIA 721
V VVDVND L + S I + + +F + G V +
Sbjct: 336 VLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGV-----NGQVTCSLT 390
Query: 722 NQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
+ ++ LDRE Y + V A + G S V++ + D N
Sbjct: 391 PRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTAR-DGGSPSLWATASVSVEVADVN 449
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEG--KE 835
DN P F Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 450 DNAPAFAQPEYTVFVKENNPPGCHI---FTVSAGDADAQKNALVSYSLVELRVGERALSS 506
Query: 836 MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 507 YVSVHAESGKV-YALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAP 563
Score = 64.1 bits (149), Expect = 4e-09
Identities = 62/221 (28%), Positives = 94/221 (42%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y E+ +
Sbjct: 443 VEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNALVSYSL-VELRVGE 501
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVF 1034
LS+ Y ++ G V + L E + +SA D G L N++++VF
Sbjct: 502 RALSS-------YVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVF 554
Query: 1035 VKDVNDHFPVFKKTWYNFN-------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQP- 1086
V D ND+ P V + V+ KV A DAD G NA L+Y +QP
Sbjct: 555 VLDENDNAPALLAPRVGGTGGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPV 614
Query: 1087 -SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+ +PF + TG +S LD ++ L V+ +D+G
Sbjct: 615 AAGASIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHG 655
Score = 62.5 bits (145), Expect = 1e-08
Identities = 82/345 (23%), Positives = 150/345 (43%), Gaps = 43/345 (12%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPT--------------GEKAFIFLIAPIGPSL 128
V V ++D+NDN P+F T ++ + E P GE A L + P+
Sbjct: 119 VDVEVKDINDNPPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENAL--LTYRLSPNE 176
Query: 129 TIPLTVPRGLTIFKDIRAFDR---DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR 185
L VP K + R D+ TP ++H +++ D G L + V LL
Sbjct: 177 YFFLDVPTSNQQVKPLGLVLRKLLDREETP--ELHL-LLTATDGGKPELTGT---VQLLI 230
Query: 186 KVLDYDAG----DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL---ISG 238
VLD + D+ V + I ++ P +A D D G+ + Y +S
Sbjct: 231 TVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHP---NASDLDEGLNGDIIYSFSSDVSP 287
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
+ + F +D ++G++ + +D + ++ + V+A P V +E++D
Sbjct: 288 DIKSKFHMDPLSGAITVIGHMDFE-----ESRAHKIPVEAVDKGFPPLAGHCTVLVEVVD 342
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFS-IDPR 357
+NDN P+ + ++ I E+ G + + D+D G NG+ T L P+ F +
Sbjct: 343 VNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSL-TPRVPFKLVSTF 401
Query: 358 SGWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGTFADSQRIA 401
+ ++ + LDRE+ S+ + V A++ +PS+ T + S +A
Sbjct: 402 KNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVA 446
Score = 56.4 bits (130), Expect = 7e-07
Identities = 40/128 (31%), Positives = 56/128 (43%), Gaps = 5/128 (3%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D+D GV + L KL S SL L+ LD ++ + + L V
Sbjct: 372 ISVFDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLVLDSALDRES-----VSAYELVVT 426
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A +P A A V +E+ D+NDN P F Y + + EN P G + V A D D +
Sbjct: 427 ARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQK 486
Query: 338 NGEFTYQL 345
N +Y L
Sbjct: 487 NALVSYSL 494
Score = 54.0 bits (124), Expect = 4e-06
Identities = 72/249 (28%), Positives = 103/249 (41%), Gaps = 31/249 (12%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
++EV N A + IPE+ GT I ++ D D G+NGQ+ V
Sbjct: 337 LVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPRV--- 393
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRV 1033
P KL + K Y+ + ++ +L ES + L ++A DGG+ L SV V
Sbjct: 394 PFKLVST---FKNYYSL-------VLDSALDRESVSAYELVVTARDGGSPSLWATASVSV 443
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPF 1093
V DVND+ P F + Y V+E + V A DAD +NA ++Y S +L
Sbjct: 444 EVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNALVSY----SLVELRV 499
Query: 1094 EISPLTGVLSVNGE---------LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDV 1144
L+ +SV+ E LD E + V ARD G D
Sbjct: 500 GERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAG-VPPLGSNVTLQVFVLDE 558
Query: 1145 NDNSPKFYA 1153
NDN+P A
Sbjct: 559 NDNAPALLA 567
Score = 49.6 bits (113), Expect = 8e-05
Identities = 55/205 (26%), Positives = 85/205 (41%), Gaps = 13/205 (6%)
Query: 700 IFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAE-----DGTIFTQKPLDREKRDVYRM 754
+ H N S + G++ + ++ DV+ DI G I +D E+ +++
Sbjct: 261 VIHPNASDLDEGLNGDIIYSFSS--DVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKI 318
Query: 755 TVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKA 814
V A +KG AG V + + D NDN P + I E+++ GT I +I
Sbjct: 319 PVEA-VDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVI---TLISV 374
Query: 815 TDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--G 872
D D G N +L + +LDRE Y+L + ARD G
Sbjct: 375 FDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPS 434
Query: 873 LSSEAELIIMIGDENDNKPEFNQIE 897
L + A + + + D NDN P F Q E
Sbjct: 435 LWATASVSVEVADVNDNAPAFAQPE 459
Score = 46.0 bits (104), Expect = 0.001
Identities = 47/158 (29%), Positives = 72/158 (45%), Gaps = 13/158 (8%)
Query: 243 LFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQVQASQLNNPLKTAQARVEIELLDLND 301
L ++ NG LF+ +D + A + L+V + PL+ V++E+ D+ND
Sbjct: 74 LLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVER---PLQVFH--VDVEVKDIND 128
Query: 302 NLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSID-PRSGW 360
N P F N+ I E+ P A+D D GEN TY+L P F +D P S
Sbjct: 129 NPPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRL-SPNEYFFLDVPTSNQ 187
Query: 361 ----LTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
L + + +LDRE L + + A + P + GT
Sbjct: 188 QVKPLGLVLRKLLDREETPELHLLLTATDGGKPELTGT 225
Score = 44.0 bits (99), Expect = 0.004
Identities = 41/156 (26%), Positives = 72/156 (46%), Gaps = 24/156 (15%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++TV D D + PVF Y +++ ENV+ ++ N ++ E
Sbjct: 218 GKPELTGTVQLLITVLDNND-----NAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
N + Y ++ DI+ F +DP +G + ++ D E +++ V A + +
Sbjct: 273 LNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFP---- 328
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
P+A V+V + DVNDN+P+ T
Sbjct: 329 ----PLAG---------HCTVLVEVVDVNDNAPQLT 351
Score = 43.2 bits (97), Expect = 0.007
Identities = 37/127 (29%), Positives = 57/127 (44%), Gaps = 10/127 (7%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNL------YEFSMKSNAKVGTVIGKVKAVDPDLGQN 492
L S V ++V +LD NDN P + + + + G V+ KV+AVD D G N
Sbjct: 545 LGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVRELVPRSVGAGHVVAKVRAVDADSGYN 604
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSV--AESPILEGRHALFVEASDQPANPSERRY 550
+ Y+LQ + + PF++ TG +S A RH L V D PS
Sbjct: 605 AWLSYELQPVA-AGASIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDH-GEPSLTAT 662
Query: 551 SLAVVTI 557
+ +V++
Sbjct: 663 ATVLVSL 669
Score = 42.7 bits (96), Expect = 0.010
Identities = 82/347 (23%), Positives = 132/347 (38%), Gaps = 30/347 (8%)
Query: 70 IGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP----IG 125
+ G ++ + +V V + DVNDN P T + + E G + + +
Sbjct: 323 VDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVN 382
Query: 126 PSLTIPLT--VPRGL-TIFKDIRAFDRDKPNTPNSDVHYS-IVSGNDDGHFALESSHKPV 181
+T LT VP L + FK+ + D S Y +V+ D G +L ++
Sbjct: 383 GQVTCSLTPRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVS 442
Query: 182 LLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELIS--GN 239
+ + V D + + + +F + A D D A + Y L+
Sbjct: 443 VEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFT--VSAGDADAQKNALVSYSLVELRVG 500
Query: 240 DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
+R L S SV+ G ++ + LD + LQ QV A P + +++ +
Sbjct: 501 ERALSSYVSVHAESGKVYALQPLDHEELELLQ-----FQVSARDAGVPPLGSNVTLQVFV 555
Query: 297 LDLNDNLPEF---EVDFYNISIVENLPN----GFSVLQVMATDKDQGENGEFTYQLDDPK 349
LD NDN P V ++ E +P G V +V A D D G N +Y+L
Sbjct: 556 LDENDNAPALLAPRVGGTGGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPVA 615
Query: 350 GAFSIDPRSGWLT--VRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
SI R G T + LD R+ V K+ PS+ T
Sbjct: 616 AGASIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPSLTAT 662
Score = 36.3 bits (80), Expect = 0.85
Identities = 20/62 (32%), Positives = 34/62 (54%), Gaps = 5/62 (8%)
Query: 1429 ERLSLNGLT-SPQATDSDIGINADIRYQILNEQAP----RFAIDPVSGTVRVVAALARDA 1483
E +S+ L P A+D D G+N DI Y ++ +P +F +DP+SG + V+ + +
Sbjct: 253 ENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEE 312
Query: 1484 GR 1485
R
Sbjct: 313 SR 314
>L11370-1|AAA36419.1| 1026|Homo sapiens protocadherin 42 protein.
Length = 1026
Score = 111 bits (266), Expect = 2e-23
Identities = 132/492 (26%), Positives = 211/492 (42%), Gaps = 45/492 (9%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
+ VT+LD NDN P F + YE + N+ +G + +VKA D D G N + Y +
Sbjct: 232 LRVTVLDTNDNAPKFERPS-YEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPE 290
Query: 505 LTITSPFKINPNTGTVSVAESPILEGRHAL--FVEASDQPANPSERRYSLAVVTIEVTRG 562
+ + +++ NTG ++V E L V A D+ NP R + VVT+ +
Sbjct: 291 V-VRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQV-VVTV---KD 345
Query: 563 TKGNKPDIPDFMGAPYEFW------VGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEE 616
N P I + G + +V T+V ++V+D E + + + +
Sbjct: 346 MNDNAPTI-EIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGD- 403
Query: 617 GVPFAVEERSGVITVVDDLSRY----NRPM-------YDFEAVALQE-NANLSIVTNATV 664
VPF + + S T D +Y P+ Y E VA+ N LS + V
Sbjct: 404 -VPFQLRQASE--TGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKV 460
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
VVDVND V + + + F + N G I +I ++ S + + + +
Sbjct: 461 QVVDVNDNAPVFTQSV-TEVAFP-ENNKPGEVIAEITASDADS---GSNAELVYSLEPEP 515
Query: 725 DVTDDIAIA-EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDN 783
I+ E G I + LDRE+R+ Y + V+A ++G S G V + + D NDN
Sbjct: 516 AAKGLFTISPETGEIQVKTSLDREQRESYELKVVAA-DRGSPSLQGTATVLVNVLDCNDN 574
Query: 784 PPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENT 843
P F + Y +MEN + + M +I D D+G NA ++ + + F + T
Sbjct: 575 DPKFMLSGYNFSVMENMPALSPVGMVTVI---DGDKGENAQVQLSVEQDNGD-FVIQNGT 630
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSK 901
G + S DRE++ Y L A D G S+ + I + DENDN P S
Sbjct: 631 GTI-LSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSH 689
Query: 902 VRIHRETKLNGT 913
+ +T+L T
Sbjct: 690 KLLTPQTRLGET 701
Score = 110 bits (265), Expect = 3e-23
Identities = 123/467 (26%), Positives = 203/467 (43%), Gaps = 40/467 (8%)
Query: 446 EVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNL 505
++ + D NDN P F S + ++ N +G++ A D D G NG+ Y+LQ +
Sbjct: 133 QIEVQDINDNTPNFA-SPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQVAEDQ 191
Query: 506 TITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRGTKG 565
P I +S + L ++ D + P L V ++ T
Sbjct: 192 EEKQPQLIVMGNLDRERWDS------YDLTIKVQDGGSPPRATSALLRVTVLD----TND 241
Query: 566 NKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDL-LHGYEEGVP--FAV 622
N P F YE + N IG SV Q++ ND+ + + + H E V +
Sbjct: 242 NAPK---FERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRL 298
Query: 623 EERSGVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDERGVL-LKG- 679
+ +G+ITV + R + F +A N S V V D+ND + ++G
Sbjct: 299 DRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGI 358
Query: 680 ---AHSPIIFHVKENSA---GAAIGQIFHTNM---SSIYGNGTGNVRFLIANQQDVTDDI 730
H + ++ E+ A A+ Q+ + +++ G+V F + + D
Sbjct: 359 GLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDS 418
Query: 731 AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHA 790
+ + T PLD EK Y + ++A + G + + + + D NDN PVF +
Sbjct: 419 K--KKYFLQTTTPLDYEKVKDYTIEIVA-VDSGNPPLSSTNSLKVQVVDVNDNAPVFTQS 475
Query: 791 TYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGE--GKEMFDVDENTGVVKF 848
E EN+K G I I A+DAD G+NA +Y+L E K +F + TG ++
Sbjct: 476 VTEVAFPENNKPGEVIAE---ITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQ- 531
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEF 893
+ SLDRE++ Y+L +VA D G L A +++ + D NDN P+F
Sbjct: 532 VKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKF 578
Score = 94.7 bits (225), Expect = 2e-18
Identities = 109/436 (25%), Positives = 175/436 (40%), Gaps = 34/436 (7%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I E++ T + + D D G N + +V + S + K+ + +
Sbjct: 370 ISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQ---- 425
Query: 1000 HVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
++ + I A+D GN L+ S++V V DVND+ PVF ++ E
Sbjct: 426 -TTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPEN 484
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP-FEISPLTGVLSVNGELDRETEDKY 1116
V+ ++ A+DAD G NA L Y ++P F ISP TG + V LDRE + Y
Sbjct: 485 NKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESY 544
Query: 1117 ILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESV 1176
L VVA D G D NDN PKF L + + + V
Sbjct: 545 ELKVVAADRG-SPSLQGTATVLVNVLDCNDNDPKFM----LSGYNFSVMENMP--ALSPV 597
Query: 1177 MMIPVYKATIEENAPIGTTVAKVFANDTDF-IGNGNGLILYSLPQRKNQQNL-------- 1227
M+ V ENA + +V + ++ DF I NG G IL SL + QQ+
Sbjct: 598 GMVTVIDGDKGENAQVQLSVEQ---DNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAV 654
Query: 1228 --GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHY 1285
G+P S+ + + V D D P S + L + + V V+ +
Sbjct: 655 DGGVPPRSAYVGVTINVLDENDNAPYITAPSNTS-HKLLTPQTRLGETVSQVAAEDFDSG 713
Query: 1286 ENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVR-AERQKYSREL 1344
N ++ Y I N + F I +G + L + +R + ++V+ ++R K R
Sbjct: 714 VNAELIYSIAGGNPYGL---FQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYG 770
Query: 1345 PHMIYPVAEDVLEGMT 1360
+++ + L T
Sbjct: 771 TALVHLYVNETLANRT 786
Score = 84.6 bits (200), Expect = 2e-15
Identities = 133/515 (25%), Positives = 204/515 (39%), Gaps = 72/515 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN IG+ A D D+G NG YE +++ D E+
Sbjct: 155 IPENTNIGSLFPIPLASDRDAGPNGVASYEL---------QVAEDQ---------EEKQP 196
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGNLNDNIS--VRVFVKDVNDHFPVFKKTWYNFNVE 1055
+IV +L E + L I DGG+ S +RV V D ND+ P F++ Y +
Sbjct: 197 QLIVMGNLDRERWDSYDLTIKVQDGGSPPRATSALLRVTVLDTNDNAPKFERPSYEAELS 256
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTY-FIQ-PSDTDLPFEISPLTGVLSVNGELDRETE 1113
E + +V A D+D G NA + Y F Q P + TG+++V G +DRE
Sbjct: 257 ENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDL 316
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNF 1173
+V+A+D G D+NDN+P L +S
Sbjct: 317 STLRFSVLAKDRG-TNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVA 375
Query: 1174 E--SVMMIPVYKATIEENAPIGTTVAKVF------ANDTDFIGNGNGLILYSLP---QRK 1222
E +V ++ V ENA + VA A++T + + P ++
Sbjct: 376 EETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKV 435
Query: 1223 NQQNL-------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVE 1275
+ G P LSST L V V DV D + PVF E+ EN N P E
Sbjct: 436 KDYTIEIVAVDSGNPPLSSTNSLKVQVVDVND-----NAPVFTQSVTEVAFPEN-NKPGE 489
Query: 1276 LVS-LNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEV-IV 1333
+++ + ++ E + + F I P G + + S DRE +++YE+ +V
Sbjct: 490 VIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVV 549
Query: 1334 RAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAI 1391
A+R S L+G V+V + D NDN PKF + N ++ +
Sbjct: 550 AADRGSPS--------------LQG----TATVLVNVLDCNDNDPKFMLSGYNFSVMENM 591
Query: 1392 PTTAPFGYQVMQLKGAIGHHPTASRTVRADTDELV 1426
P +P G V + G G + +V D + V
Sbjct: 592 PALSPVG-MVTVIDGDKGENAQVQLSVEQDNGDFV 625
Score = 81.8 bits (193), Expect = 2e-14
Identities = 73/257 (28%), Positives = 124/257 (48%), Gaps = 27/257 (10%)
Query: 643 YDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPII-FHVKENSAGAAIGQIF 701
++ L +NA+ ++ + V D+ND SP+I + EN+ IG +F
Sbjct: 114 FEVSITDLVQNASPRLL-EGQIEVQDINDNT----PNFASPVITLAIPENTN---IGSLF 165
Query: 702 HTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTV-IAEF 760
++S G V + + V +D + + LDRE+ D Y +T+ + +
Sbjct: 166 PIPLASDRDAGPNGVA---SYELQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDG 221
Query: 761 NKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEG 820
+ + + +VT+ D NDN P FE +YE + ENS IG + +KA D+D+G
Sbjct: 222 GSPPRATSALLRVTVL--DTNDNAPKFERPSYEAELSENSPIGHSVIQ---VKANDSDQG 276
Query: 821 TNALFMYTLFGEGKE----MFDVDENTGVVKFIGDSLDREKKIMYKLSLVARD--TGGLS 874
NA YT F + E + +D NTG++ G +DRE + S++A+D T S
Sbjct: 277 ANAEIEYT-FHQAPEVVRRLLRLDRNTGLITVQG-PVDREDLSTLRFSVLAKDRGTNPKS 334
Query: 875 SEAELIIMIGDENDNKP 891
+ A++++ + D NDN P
Sbjct: 335 ARAQVVVTVKDMNDNAP 351
Score = 80.6 bits (190), Expect = 4e-14
Identities = 60/182 (32%), Positives = 87/182 (47%), Gaps = 19/182 (10%)
Query: 213 LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
LFP P+ A D+D G YEL D+ + L + LD + + +++
Sbjct: 164 LFPIPL-ASDRDAGPNGVASYELQVAEDQ-----EEKQPQLIVMGNLDRE-----RWDSY 212
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
L ++ +P + A + + +LD NDN P+FE Y + EN P G SV+QV A D
Sbjct: 213 DLTIKVQDGGSPPRATSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKAND 272
Query: 333 KDQGENGEFTYQLDDP----KGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE--T 386
DQG N E Y + +D +G +TV Q +DRE S+LR V AK+ T
Sbjct: 273 SDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITV--QGPVDREDLSTLRFSVLAKDRGT 330
Query: 387 NP 388
NP
Sbjct: 331 NP 332
Score = 79.0 bits (186), Expect = 1e-13
Identities = 93/381 (24%), Positives = 158/381 (41%), Gaps = 21/381 (5%)
Query: 414 LEKTTYVFPDKVGTKTENIEYYDE---QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMK 470
L+ TT + +KV T I D L S +++V ++D NDN PVF S + E +
Sbjct: 424 LQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQS-VTEVAFP 482
Query: 471 SNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG 530
N K G VI ++ A D D G N ++Y L+ F I+P TG + V S E
Sbjct: 483 ENNKPGEVIAEITASDADSGSNAELVYSLE--PEPAAKGLFTISPETGEIQVKTSLDREQ 540
Query: 531 R--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGI 588
R + L V A+D+ +PS + + +V + N D P FM + Y F V N+
Sbjct: 541 RESYELKVVAADR-GSPSLQGTATVLVNV-----LDCNDND-PKFMLSGYNFSVMENMPA 593
Query: 589 GTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAV 648
+ VG + V D + + L + G F ++ +G I R + Y F+
Sbjct: 594 LSPVGMVTVIDGDKGENAQVQLSVEQDNG-DFVIQNGTGTILSSLSFDREQQSTYTFQLK 652
Query: 649 ALQENA-NLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSS 707
A+ S T++V+D ND + +++ + G + Q+ + S
Sbjct: 653 AVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDS 712
Query: 708 IYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ + IA + G I +K ++R ++R+ V+ ++G
Sbjct: 713 ---GVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRL-VVKVSDRGKPPR 768
Query: 768 AGIYQVTIYIEDENDNPPVFE 788
G V +Y+ + N + E
Sbjct: 769 YGTALVHLYVNETLANRTLLE 789
Score = 77.0 bits (181), Expect = 5e-13
Identities = 97/380 (25%), Positives = 166/380 (43%), Gaps = 41/380 (10%)
Query: 45 DSDSPQNVVKFRLGCD-FDEGDDLVRI---GAGLNQISAYLSVTVYIEDVNDNVPIFLDT 100
+ PQ +V L + +D D +++ G+ SA L VTV D NDN P F
Sbjct: 192 EEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRATSALLRVTVL--DTNDNAPKFERP 249
Query: 101 PYHVTVDELTPTGEKAFIFLI--APIGPSLTIPLTVPRGLTIFKDIRAFDRDK------- 151
Y + E +P G + G + I T + + + + DR+
Sbjct: 250 SYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQG 309
Query: 152 --PNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQ---LVIMASGK 206
S + +S+++ D G +S+ V++ K ++ +A E + LV G
Sbjct: 310 PVDREDLSTLRFSVLA-KDRGTNP-KSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGM 367
Query: 207 RIHKEILFPEPIHAI----DQDLGVGATLRYELISGNDRKLFSLDSVNGS-----LFLEK 257
E + E A+ D+D G A + +++G+ S GS FL+
Sbjct: 368 ANISEDVAEETAVALVQVSDRDEGENAAVTC-VVAGDVPFQLRQASETGSDSKKKYFLQT 426
Query: 258 ELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVE 317
LD E + + +++ A NP ++ ++++++D+NDN P F ++ E
Sbjct: 427 TTPLDYE---KVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPE 483
Query: 318 NLPNGFSVLQVMATDKDQGENGEFTYQLD-DP--KGAFSIDPRSGWLTVRNQTVLDREAH 374
N G + ++ A+D D G N E Y L+ +P KG F+I P +G + V+ T LDRE
Sbjct: 484 NNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVK--TSLDREQR 541
Query: 375 SSLRMKVYAKET-NPSVVGT 393
S +KV A + +PS+ GT
Sbjct: 542 ESYELKVVAADRGSPSLQGT 561
Score = 73.3 bits (172), Expect = 6e-12
Identities = 52/167 (31%), Positives = 80/167 (47%), Gaps = 8/167 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRK-LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
I A D D G A L Y L K LF++ G + ++ LD + Q ++ L+V
Sbjct: 494 ITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDRE-----QRESYELKV 548
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A+ +P A V + +LD NDN P+F + YN S++EN+P V V D D+G
Sbjct: 549 VAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKG 608
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
EN + ++ G F I +G T+ + DRE S+ ++ A
Sbjct: 609 ENAQVQLSVEQDNGDFVIQNGTG--TILSSLSFDREQQSTYTFQLKA 653
Score = 68.1 bits (159), Expect = 2e-10
Identities = 143/585 (24%), Positives = 238/585 (40%), Gaps = 89/585 (15%)
Query: 775 IYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGK 834
I ++D NDN P F I EN+ IG+ + I A+D D G N + Y L +
Sbjct: 134 IEVQDINDNTPNFASPVITLAIPENTNIGS---LFPIPLASDRDAGPNGVASYEL----Q 186
Query: 835 EMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
D +E + +G+ LDRE+ Y L++ +D G ++ A L + + D NDN P+
Sbjct: 187 VAEDQEEKQPQLIVMGN-LDRERWDSYDLTIKVQDGGSPPRATSALLRVTVLDTNDNAPK 245
Query: 893 FNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIK 952
F + E N G ++I+VK A D DQ N I T +
Sbjct: 246 F------ERPSYEAELSENSPIGHSVIQVK-----ANDSDQ-------GANAEIEYTFHQ 287
Query: 953 LNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE 1012
+ + +R + N+ + + + L R+ V+ + G + P +
Sbjct: 288 APEV-----VRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRG------TNPKSAR 336
Query: 1013 FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDA 1072
++ ++ D +NDN + + ++ + + N + + A+ T L V +D
Sbjct: 337 AQVVVTVKD---MNDN-APTIEIRGIG--LVTHQDGMANISEDVAEETAVAL--VQVSDR 388
Query: 1073 DFGQNANLTYFIQPSDTDLPFEI--SPLTG-------VLSVNGELDRETEDKYILTVVAR 1123
D G+NA +T + D+PF++ + TG L LD E Y + +VA
Sbjct: 389 DEGENAAVTCVVA---GDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAV 445
Query: 1124 DNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYK 1183
D+G DVNDN+P F + E PE +N E + I
Sbjct: 446 DSG-NPPLSSTNSLKVQVVDVNDNAPVF--TQSVTEVAFPE----NNKPGEVIAEITASD 498
Query: 1184 ATIEENAPIGTTVAKVFANDTDFI---GNGNGLILYSLPQRKNQQ--------NLGLPSL 1232
A NA + ++ A F G + SL + + + + G PSL
Sbjct: 499 ADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSL 558
Query: 1233 SSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNA--PVELVSLNLTEHYENFKM 1290
TA ++V V D D + P F+ Y + EN+ A PV +V++ + EN ++
Sbjct: 559 QGTATVLVNVLDCND-----NDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQV 613
Query: 1291 RYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
+ + +N FVI GT+ S DRE + TY ++A
Sbjct: 614 QLSVEQDNG-----DFVIQNGTGTILSSLSFDREQQSTYTFQLKA 653
Score = 62.9 bits (146), Expect = 9e-09
Identities = 87/343 (25%), Positives = 136/343 (39%), Gaps = 27/343 (7%)
Query: 66 DLVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI--AP 123
++V + +G +S+ S+ V + DVNDN P+F + V E GE A
Sbjct: 441 EIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDAD 500
Query: 124 IGPSLTI-----PLTVPRGL-TIFKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALES 176
G + + P +GL TI + Y + V D G +L+
Sbjct: 501 SGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQG 560
Query: 177 SHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEP-IHAIDQDLGVGATLRYEL 235
+ +L VLD + D +F L + L P + ID D G A ++ +
Sbjct: 561 T---ATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSV 617
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIE 295
N + NG+ + L D E Q +T+ Q++A P ++A V I
Sbjct: 618 EQDNGDFVIQ----NGTGTILSSLSFDRE---QQSTYTFQLKAVDGGVPPRSAYVGVTIN 670
Query: 296 LLDLNDNLPEFEV--DFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGA 351
+LD NDN P + + + G +V QV A D D G N E Y + +P G
Sbjct: 671 VLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGL 730
Query: 352 FSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKET-NPSVVGT 393
F I SG +T+ + ++R H R+ V + P GT
Sbjct: 731 FQIGSHSGAITLEKE--IERRHHGLHRLVVKVSDRGKPPRYGT 771
Score = 58.0 bits (134), Expect = 2e-07
Identities = 123/557 (22%), Positives = 215/557 (38%), Gaps = 67/557 (12%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
++ +PE P T I L A D G + + + EV P ++ ++ +
Sbjct: 39 VYKVPEEQPPNTLIGSLAA---DYGFP-DVGHLYKLEVGAPYLRVDGKTGDIFTTETSID 94
Query: 997 RHGHVIVARSLPPES---EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFN 1053
R G LP + EF ++I+ L + ++ V+D+ND+ P F
Sbjct: 95 REGLRECQNQLPGDPCILEFEVSITDLVQNASPRLLEGQIEVQDINDNTPNFASPVITLA 154
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETE 1113
+ E + A+D D G N +Y +Q ++ E P L V G LDRE
Sbjct: 155 IPENTNIGSLFPIPLASDRDAGPNGVASYELQVAEDQE--EKQPQ---LIVMGNLDRERW 209
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNF 1173
D Y LT+ +D G D NDN+PKF + P
Sbjct: 210 DSYDLTIKVQDGGSPPRATSALLRVTVL-DTNDNAPKF---------ERPS--------- 250
Query: 1174 ESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLS 1233
Y+A + EN+PIG +V +V AND+D N I Y+ Q L
Sbjct: 251 --------YEAELSENSPIGHSVIQVKANDSD--QGANAEIEYTFHQAPEVVRRLLRLDR 300
Query: 1234 STAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYENFKMRYY 1293
+T ++TV D ++S + ++ A V + ++ ++ ++R
Sbjct: 301 NTG--LITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGI 358
Query: 1294 ILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAE 1353
L + + + LV+ DR+ + V + ++P + +E
Sbjct: 359 GLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTC-----VVAGDVPFQLRQASE 413
Query: 1354 DVLEGMTKYDVKVVV-----RIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQLKGAI 1408
+ KY ++ ++KD +GN PL +T QV+ +
Sbjct: 414 TGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPL----SSTNSLKVQVVDVN--- 466
Query: 1409 GHHPTASRTVRADTDELVFFERLSLNGLTSP-QATDSDIGINADIRYQILNEQAPR--FA 1465
+ P +++V E+ F E + + A+D+D G NA++ Y + E A + F
Sbjct: 467 DNAPVFTQSV----TEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFT 522
Query: 1466 IDPVSGTVRVVAALARD 1482
I P +G ++V +L R+
Sbjct: 523 ISPETGEIQVKTSLDRE 539
Score = 43.6 bits (98), Expect = 0.006
Identities = 26/94 (27%), Positives = 51/94 (54%), Gaps = 4/94 (4%)
Query: 255 LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV---EIELLDLNDNLPEFEVDFY 311
+++E + ++ L + +L+ + S + + ++ A R+ +IE+ D+NDN P F
Sbjct: 93 IDREGLRECQNQLPGDPCILEFEVS-ITDLVQNASPRLLEGQIEVQDINDNTPNFASPVI 151
Query: 312 NISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
++I EN G +A+D+D G NG +Y+L
Sbjct: 152 TLAIPENTNIGSLFPIPLASDRDAGPNGVASYEL 185
>BC035812-1|AAH35812.1| 1060|Homo sapiens protocadherin 1 protein.
Length = 1060
Score = 111 bits (266), Expect = 2e-23
Identities = 132/492 (26%), Positives = 211/492 (42%), Gaps = 45/492 (9%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
+ VT+LD NDN P F + YE + N+ +G + +VKA D D G N + Y +
Sbjct: 266 LRVTVLDTNDNAPKFERPS-YEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPE 324
Query: 505 LTITSPFKINPNTGTVSVAESPILEGRHAL--FVEASDQPANPSERRYSLAVVTIEVTRG 562
+ + +++ NTG ++V E L V A D+ NP R + VVT+ +
Sbjct: 325 V-VRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQV-VVTV---KD 379
Query: 563 TKGNKPDIPDFMGAPYEFW------VGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEE 616
N P I + G + +V T+V ++V+D E + + + +
Sbjct: 380 MNDNAPTI-EIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGD- 437
Query: 617 GVPFAVEERSGVITVVDDLSRY----NRPM-------YDFEAVALQE-NANLSIVTNATV 664
VPF + + S T D +Y P+ Y E VA+ N LS + V
Sbjct: 438 -VPFQLRQASE--TGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKV 494
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
VVDVND V + + + F + N G I +I ++ S + + + +
Sbjct: 495 QVVDVNDNAPVFTQSV-TEVAFP-ENNKPGEVIAEITASDADS---GSNAELVYSLEPEP 549
Query: 725 DVTDDIAIA-EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDN 783
I+ E G I + LDRE+R+ Y + V+A ++G S G V + + D NDN
Sbjct: 550 AAKGLFTISPETGEIQVKTSLDREQRESYELKVVAA-DRGSPSLQGTATVLVNVLDCNDN 608
Query: 784 PPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENT 843
P F + Y +MEN + + M +I D D+G NA ++ + + F + T
Sbjct: 609 DPKFMLSGYNFSVMENMPALSPVGMVTVI---DGDKGENAQVQLSVEQDNGD-FVIQNGT 664
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSK 901
G + S DRE++ Y L A D G S+ + I + DENDN P S
Sbjct: 665 GTI-LSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSH 723
Query: 902 VRIHRETKLNGT 913
+ +T+L T
Sbjct: 724 KLLTPQTRLGET 735
Score = 107 bits (257), Expect = 3e-22
Identities = 125/475 (26%), Positives = 207/475 (43%), Gaps = 44/475 (9%)
Query: 446 EVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNL 505
++ + D NDN P F S + ++ N +G++ A D D G NG+ Y+LQ +
Sbjct: 155 QIEVQDINDNTPNFA-SPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQ--AGP 211
Query: 506 TITSPFKINPNTGTVSVAESPILEGR--------HALFVEASDQPANPSERRYSLAVVTI 557
F + I+ G + L ++ D + P R S A++ +
Sbjct: 212 EAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPP---RASSALLRV 268
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDL-LHGYEE 616
V T N P F YE + N IG SV Q++ ND+ + + + H E
Sbjct: 269 TVL-DTNDNAPK---FERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPE 324
Query: 617 GVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDER 673
V ++ +G+ITV + R + F +A N S V V D+ND
Sbjct: 325 VVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNA 384
Query: 674 GVL-LKG----AHSPIIFHVKENSA---GAAIGQIFHTNM---SSIYGNGTGNVRFLIAN 722
+ ++G H + ++ E+ A A+ Q+ + +++ G+V F +
Sbjct: 385 PTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQ 444
Query: 723 QQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEND 782
+ D + + T PLD EK Y + ++A + G + + + + D ND
Sbjct: 445 ASETGSDSK--KKYFLQTTTPLDYEKVKDYTIEIVA-VDSGNPPLSSTNSLKVQVVDVND 501
Query: 783 NPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGE--GKEMFDVD 840
N PVF + E EN+K G I I A+DAD G+NA +Y+L E K +F +
Sbjct: 502 NAPVFTQSVTEVAFPENNKPGEVIAE---ITASDADSGSNAELVYSLEPEPAAKGLFTIS 558
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEF 893
TG ++ + SLDRE++ Y+L +VA D G L A +++ + D NDN P+F
Sbjct: 559 PETGEIQ-VKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKF 612
Score = 94.7 bits (225), Expect = 2e-18
Identities = 109/436 (25%), Positives = 175/436 (40%), Gaps = 34/436 (7%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I E++ T + + D D G N + +V + S + K+ + +
Sbjct: 404 ISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQ---- 459
Query: 1000 HVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
++ + I A+D GN L+ S++V V DVND+ PVF ++ E
Sbjct: 460 -TTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPEN 518
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP-FEISPLTGVLSVNGELDRETEDKY 1116
V+ ++ A+DAD G NA L Y ++P F ISP TG + V LDRE + Y
Sbjct: 519 NKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESY 578
Query: 1117 ILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESV 1176
L VVA D G D NDN PKF L + + + V
Sbjct: 579 ELKVVAADRG-SPSLQGTATVLVNVLDCNDNDPKFM----LSGYNFSVMENMP--ALSPV 631
Query: 1177 MMIPVYKATIEENAPIGTTVAKVFANDTDF-IGNGNGLILYSLPQRKNQQNL-------- 1227
M+ V ENA + +V + ++ DF I NG G IL SL + QQ+
Sbjct: 632 GMVTVIDGDKGENAQVQLSVEQ---DNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAV 688
Query: 1228 --GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHY 1285
G+P S+ + + V D D P S + L + + V V+ +
Sbjct: 689 DGGVPPRSAYVGVTINVLDENDNAPYITAPSNTS-HKLLTPQTRLGETVSQVAAEDFDSG 747
Query: 1286 ENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVR-AERQKYSREL 1344
N ++ Y I N + F I +G + L + +R + ++V+ ++R K R
Sbjct: 748 VNAELIYSIAGGNPYGL---FQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYG 804
Query: 1345 PHMIYPVAEDVLEGMT 1360
+++ + L T
Sbjct: 805 TALVHLYVNETLANRT 820
Score = 92.3 bits (219), Expect = 1e-17
Identities = 134/515 (26%), Positives = 205/515 (39%), Gaps = 60/515 (11%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN IG+ A D D+G NG YE + P L+V E+
Sbjct: 177 IPENTNIGSLFPIPLASDRDAGPNGVASYELQAG----PEAQELFGLQVAEDQ--EEKQP 230
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+IV +L E + L I DGG+ + +RV V D ND+ P F++ Y +
Sbjct: 231 QLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELS 290
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTY-FIQ-PSDTDLPFEISPLTGVLSVNGELDRETE 1113
E + +V A D+D G NA + Y F Q P + TG+++V G +DRE
Sbjct: 291 ENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDL 350
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNF 1173
+V+A+D G D+NDN+P L +S
Sbjct: 351 STLRFSVLAKDRG-TNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVA 409
Query: 1174 E--SVMMIPVYKATIEENAPIGTTVAKVF------ANDTDFIGNGNGLILYSLP---QRK 1222
E +V ++ V ENA + VA A++T + + P ++
Sbjct: 410 EETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKV 469
Query: 1223 NQQNL-------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVE 1275
+ G P LSST L V V DV D + PVF E+ EN N P E
Sbjct: 470 KDYTIEIVAVDSGNPPLSSTNSLKVQVVDVND-----NAPVFTQSVTEVAFPEN-NKPGE 523
Query: 1276 LVS-LNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEV-IV 1333
+++ + ++ E + + F I P G + + S DRE +++YE+ +V
Sbjct: 524 VIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVV 583
Query: 1334 RAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKF--TNGNRPLVTAI 1391
A+R S L+G V+V + D NDN PKF + N ++ +
Sbjct: 584 AADRGSPS--------------LQG----TATVLVNVLDCNDNDPKFMLSGYNFSVMENM 625
Query: 1392 PTTAPFGYQVMQLKGAIGHHPTASRTVRADTDELV 1426
P +P G V + G G + +V D + V
Sbjct: 626 PALSPVG-MVTVIDGDKGENAQVQLSVEQDNGDFV 659
Score = 88.6 bits (210), Expect = 1e-16
Identities = 65/186 (34%), Positives = 93/186 (50%), Gaps = 15/186 (8%)
Query: 213 LFPEPIHAIDQDLGVGATLRYELISGND-RKLFSLDSVNGSLFLEKELDLDAEHNLQA-- 269
LFP P+ A D+D G YEL +G + ++LF L EK+ L NL
Sbjct: 186 LFPIPL-ASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQE--EKQPQLIVMGNLDRER 242
Query: 270 -NTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQV 328
+++ L ++ +P + + A + + +LD NDN P+FE Y + EN P G SV+QV
Sbjct: 243 WDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQV 302
Query: 329 MATDKDQGENGEFTYQLDDP----KGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAK 384
A D DQG N E Y + +D +G +TV Q +DRE S+LR V AK
Sbjct: 303 KANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITV--QGPVDREDLSTLRFSVLAK 360
Query: 385 E--TNP 388
+ TNP
Sbjct: 361 DRGTNP 366
Score = 79.0 bits (186), Expect = 1e-13
Identities = 93/381 (24%), Positives = 158/381 (41%), Gaps = 21/381 (5%)
Query: 414 LEKTTYVFPDKVGTKTENIEYYDE---QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMK 470
L+ TT + +KV T I D L S +++V ++D NDN PVF S + E +
Sbjct: 458 LQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQS-VTEVAFP 516
Query: 471 SNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG 530
N K G VI ++ A D D G N ++Y L+ F I+P TG + V S E
Sbjct: 517 ENNKPGEVIAEITASDADSGSNAELVYSLE--PEPAAKGLFTISPETGEIQVKTSLDREQ 574
Query: 531 R--HALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGI 588
R + L V A+D+ +PS + + +V + N D P FM + Y F V N+
Sbjct: 575 RESYELKVVAADR-GSPSLQGTATVLVNV-----LDCNDND-PKFMLSGYNFSVMENMPA 627
Query: 589 GTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAV 648
+ VG + V D + + L + G F ++ +G I R + Y F+
Sbjct: 628 LSPVGMVTVIDGDKGENAQVQLSVEQDNG-DFVIQNGTGTILSSLSFDREQQSTYTFQLK 686
Query: 649 ALQENA-NLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSS 707
A+ S T++V+D ND + +++ + G + Q+ + S
Sbjct: 687 AVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDS 746
Query: 708 IYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG 767
+ + IA + G I +K ++R ++R+ V+ ++G
Sbjct: 747 ---GVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRL-VVKVSDRGKPPR 802
Query: 768 AGIYQVTIYIEDENDNPPVFE 788
G V +Y+ + N + E
Sbjct: 803 YGTALVHLYVNETLANRTLLE 823
Score = 76.6 bits (180), Expect = 6e-13
Identities = 97/380 (25%), Positives = 166/380 (43%), Gaps = 41/380 (10%)
Query: 45 DSDSPQNVVKFRLGCD-FDEGDDLVRI---GAGLNQISAYLSVTVYIEDVNDNVPIFLDT 100
+ PQ +V L + +D D +++ G+ SA L VTV D NDN P F
Sbjct: 226 EEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVL--DTNDNAPKFERP 283
Query: 101 PYHVTVDELTPTGEKAFIFLI--APIGPSLTIPLTVPRGLTIFKDIRAFDRDK------- 151
Y + E +P G + G + I T + + + + DR+
Sbjct: 284 SYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQG 343
Query: 152 --PNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQ---LVIMASGK 206
S + +S+++ D G +S+ V++ K ++ +A E + LV G
Sbjct: 344 PVDREDLSTLRFSVLA-KDRGTNP-KSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGM 401
Query: 207 RIHKEILFPEPIHAI----DQDLGVGATLRYELISGNDRKLFSLDSVNGS-----LFLEK 257
E + E A+ D+D G A + +++G+ S GS FL+
Sbjct: 402 ANISEDVAEETAVALVQVSDRDEGENAAVTC-VVAGDVPFQLRQASETGSDSKKKYFLQT 460
Query: 258 ELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVE 317
LD E + + +++ A NP ++ ++++++D+NDN P F ++ E
Sbjct: 461 TTPLDYE---KVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPE 517
Query: 318 NLPNGFSVLQVMATDKDQGENGEFTYQLD-DP--KGAFSIDPRSGWLTVRNQTVLDREAH 374
N G + ++ A+D D G N E Y L+ +P KG F+I P +G + V+ T LDRE
Sbjct: 518 NNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVK--TSLDREQR 575
Query: 375 SSLRMKVYAKET-NPSVVGT 393
S +KV A + +PS+ GT
Sbjct: 576 ESYELKVVAADRGSPSLQGT 595
Score = 73.3 bits (172), Expect = 6e-12
Identities = 52/167 (31%), Positives = 80/167 (47%), Gaps = 8/167 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRK-LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
I A D D G A L Y L K LF++ G + ++ LD + Q ++ L+V
Sbjct: 528 ITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDRE-----QRESYELKV 582
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A+ +P A V + +LD NDN P+F + YN S++EN+P V V D D+G
Sbjct: 583 VAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKG 642
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
EN + ++ G F I +G T+ + DRE S+ ++ A
Sbjct: 643 ENAQVQLSVEQDNGDFVIQNGTG--TILSSLSFDREQQSTYTFQLKA 687
Score = 70.9 bits (166), Expect = 3e-11
Identities = 147/593 (24%), Positives = 242/593 (40%), Gaps = 93/593 (15%)
Query: 775 IYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG--E 832
I ++D NDN P F I EN+ IG+ + I A+D D G N + Y L E
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGS---LFPIPLASDRDAGPNGVASYELQAGPE 212
Query: 833 GKEMF------DVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIG 884
+E+F D +E + +G +LDRE+ Y L++ +D G +S A L + +
Sbjct: 213 AQELFGLQVAEDQEEKQPQLIVMG-NLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVL 271
Query: 885 DENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENI 944
D NDN P+F + E N G ++I+VK A D DQ N
Sbjct: 272 DTNDNAPKF------ERPSYEAELSENSPIGHSVIQVK-----ANDSDQ-------GANA 313
Query: 945 PIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVA 1004
I T + + + +R + N+ + + + L R+ V+ + G
Sbjct: 314 EIEYTFHQAPEV-----VRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRG----- 363
Query: 1005 RSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVL 1064
+ P + ++ ++ D +NDN + + ++ + + N + + A+ T L
Sbjct: 364 -TNPKSARAQVVVTVKD---MNDN-APTIEIRGIG--LVTHQDGMANISEDVAEETAVAL 416
Query: 1065 GKVDATDADFGQNANLTYFIQPSDTDLPFEI--SPLTG-------VLSVNGELDRETEDK 1115
V +D D G+NA +T + D+PF++ + TG L LD E
Sbjct: 417 --VQVSDRDEGENAAVTCVVA---GDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKD 471
Query: 1116 YILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFES 1175
Y + +VA D+G DVNDN+P F + E PE +N E
Sbjct: 472 YTIEIVAVDSG-NPPLSSTNSLKVQVVDVNDNAPVF--TQSVTEVAFPE----NNKPGEV 524
Query: 1176 VMMIPVYKATIEENAPIGTTVAKVFANDTDFI---GNGNGLILYSLPQRKNQQ------- 1225
+ I A NA + ++ A F G + SL + + +
Sbjct: 525 IAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVA 584
Query: 1226 -NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNA--PVELVSLNLT 1282
+ G PSL TA ++V V D D + P F+ Y + EN+ A PV +V++
Sbjct: 585 ADRGSPSLQGTATVLVNVLDCND-----NDPKFMLSGYNFSVMENMPALSPVGMVTVIDG 639
Query: 1283 EHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
+ EN +++ + +N FVI GT+ S DRE + TY ++A
Sbjct: 640 DKGENAQVQLSVEQDNG-----DFVIQNGTGTILSSLSFDREQQSTYTFQLKA 687
Score = 62.9 bits (146), Expect = 9e-09
Identities = 87/343 (25%), Positives = 136/343 (39%), Gaps = 27/343 (7%)
Query: 66 DLVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI--AP 123
++V + +G +S+ S+ V + DVNDN P+F + V E GE A
Sbjct: 475 EIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDAD 534
Query: 124 IGPSLTI-----PLTVPRGL-TIFKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALES 176
G + + P +GL TI + Y + V D G +L+
Sbjct: 535 SGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQG 594
Query: 177 SHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEP-IHAIDQDLGVGATLRYEL 235
+ +L VLD + D +F L + L P + ID D G A ++ +
Sbjct: 595 T---ATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSV 651
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIE 295
N + NG+ + L D E Q +T+ Q++A P ++A V I
Sbjct: 652 EQDNGDFVIQ----NGTGTILSSLSFDRE---QQSTYTFQLKAVDGGVPPRSAYVGVTIN 704
Query: 296 LLDLNDNLPEFEV--DFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGA 351
+LD NDN P + + + G +V QV A D D G N E Y + +P G
Sbjct: 705 VLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGL 764
Query: 352 FSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKET-NPSVVGT 393
F I SG +T+ + ++R H R+ V + P GT
Sbjct: 765 FQIGSHSGAITLEKE--IERRHHGLHRLVVKVSDRGKPPRYGT 805
Score = 54.4 bits (125), Expect = 3e-06
Identities = 123/564 (21%), Positives = 215/564 (38%), Gaps = 69/564 (12%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
++ +PE P T I L A D G + + + EV P ++ ++ +
Sbjct: 61 VYKVPEEQPPNTLIGSLAA---DYGFP-DVGHLYKLEVGAPYLRVDGKTGDIFTTETSID 116
Query: 997 RHGHVIVARSLPPES---EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFN 1053
R G LP + EF ++I+ L + ++ V+D+ND+ P F
Sbjct: 117 REGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLA 176
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQ--PSDTDL-----PFEISPLTGVLSVNG 1106
+ E + A+D D G N +Y +Q P +L + L V G
Sbjct: 177 IPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMG 236
Query: 1107 ELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEAD 1166
LDRE D Y LT+ +D G D NDN+PKF + P
Sbjct: 237 NLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVL-DTNDNAPKF---------ERPS-- 284
Query: 1167 ELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQN 1226
Y+A + EN+PIG +V +V AND+D N I Y+ Q
Sbjct: 285 ---------------YEAELSENSPIGHSVIQVKANDSD--QGANAEIEYTFHQAPEVVR 327
Query: 1227 LGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE 1286
L +T ++TV D ++S + ++ A V + ++ ++
Sbjct: 328 RLLRLDRNTG--LITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAP 385
Query: 1287 NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPH 1346
++R L + + + LV+ DR+ + V + ++P
Sbjct: 386 TIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTC-----VVAGDVPF 440
Query: 1347 MIYPVAEDVLEGMTKYDVKVVV-----RIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQV 1401
+ +E + KY ++ ++KD +GN PL +T QV
Sbjct: 441 QLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPL----SSTNSLKVQV 496
Query: 1402 MQLKGAIGHHPTASRTVRADTDELVFFERLSLNGLTSP-QATDSDIGINADIRYQILNEQ 1460
+ + + P +++V E+ F E + + A+D+D G NA++ Y + E
Sbjct: 497 VDVN---DNAPVFTQSV----TEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEP 549
Query: 1461 APR--FAIDPVSGTVRVVAALARD 1482
A + F I P +G ++V +L R+
Sbjct: 550 AAKGLFTISPETGEIQVKTSLDRE 573
Score = 41.9 bits (94), Expect = 0.017
Identities = 25/94 (26%), Positives = 50/94 (53%), Gaps = 4/94 (4%)
Query: 255 LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV---EIELLDLNDNLPEFEVDFY 311
+++E + ++ L + +L+ + S + + ++ R+ +IE+ D+NDN P F
Sbjct: 115 IDREGLRECQNQLPGDPCILEFEVS-ITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVI 173
Query: 312 NISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
++I EN G +A+D+D G NG +Y+L
Sbjct: 174 TLAIPENTNIGSLFPIPLASDRDAGPNGVASYEL 207
>AY013874-1|AAK21987.1| 896|Homo sapiens protocadherin 10 protein.
Length = 896
Score = 111 bits (266), Expect = 2e-23
Identities = 120/429 (27%), Positives = 180/429 (41%), Gaps = 45/429 (10%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
E G ++ + +DRE+ + + + + ++QV I + D NDNPP F
Sbjct: 69 ETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELFQVEIEVLDINDNPPSFPEPDLT 128
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDV----DENTGVVKFI 849
I E++ GT +++ A D D GTN+L Y + DV D N +
Sbjct: 129 VEISESATPGTRFPLES---AFDPDVGTNSLRDYEITPNSYFSLDVQTQGDGNRFAELVL 185
Query: 850 GDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETK 909
LDRE++ +++ L A D GG +G+ + + +
Sbjct: 186 EKPLDREQQAVHRYVLTAVDGGGGGG-------VGEGGGG---------GGGAGLPPQQQ 229
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
GTA TI V N DQ +PEN P GT +I+LNA D D G NG++ Y
Sbjct: 230 RTGTALLTI-RVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYS 288
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALD-GGN-L 1025
F+S +I P + F ++ R G + V+ L E +++ + A D G N +
Sbjct: 289 FSS--HISP--------RARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAV 338
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
+ V V V D ND+ P + V E V+ TD D +N + +
Sbjct: 339 PAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELL 398
Query: 1086 PSDTDLPFEI-SPLTGVLSVNGE--LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXX 1142
D+PF + S ++ E LDRE D Y LTVVARD G
Sbjct: 399 ---GDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRG-EPALSTSKSIQVQVS 454
Query: 1143 DVNDNSPKF 1151
DVNDN+P+F
Sbjct: 455 DVNDNAPRF 463
Score = 108 bits (260), Expect = 1e-22
Identities = 125/494 (25%), Positives = 201/494 (40%), Gaps = 48/494 (9%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E + E + VE+ +LD NDN P F +L + +A GT A DPD+G
Sbjct: 94 HLEVFLENPLELFQVEIEVLDINDNPPSFPEPDL-TVEISESATPGTRFPLESAFDPDVG 152
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPAN--- 544
N + Y++ S ++ + + N V E P+ + H + A D
Sbjct: 153 TNSLRDYEITPNSYFSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGV 212
Query: 545 -------------PSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTS 591
P ++R A++TI V + ++P F Y + N GT
Sbjct: 213 GEGGGGGGGAGLPPQQQRTGTALLTIRVL----DSNDNVPAFDQPVYTVSLPENSPPGTL 268
Query: 592 VGQIRVNDAFE-QN-DVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEA 647
V Q+ D E QN +V Y F + R+G + V +L P+Y
Sbjct: 269 VIQLNATDPDEGQNGEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYV 328
Query: 648 VALQENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMS 706
A N + V V+D ND + + S + V E +A + +F
Sbjct: 329 QAKDLGPNAVPAHCKVLVRVLDANDNAPEI---SFSTVKEAVSEGAAPGTVVALFSVTDR 385
Query: 707 SIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVIS 766
NG V+ + + TI T+ PLDRE D Y +TV+A ++G +
Sbjct: 386 DSEENG--QVQCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVAR-DRGEPA 442
Query: 767 GAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFM 826
+ + + + D NDN P F Y+ ++ EN+ G I + ATD DEG NA
Sbjct: 443 LSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYA---VSATDRDEGANAQLA 499
Query: 827 YTLFG---EGKEMF---DVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG---LSSEA 877
Y++ +G +F ++ G + + S D E+ + + ARD G L+ A
Sbjct: 500 YSILECQIQGMSVFTYVSINSENGYLYALR-SFDYEQLKDFSFQVEARDAGSPQALAGNA 558
Query: 878 ELIIMIGDENDNKP 891
+ I+I D+NDN P
Sbjct: 559 TVNILIVDQNDNAP 572
Score = 87.0 bits (206), Expect = 5e-16
Identities = 116/464 (25%), Positives = 191/464 (41%), Gaps = 46/464 (9%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLT 506
+ +LD+NDN P F +Y S+ N+ GT++ ++ A DPD GQNG V+Y +
Sbjct: 238 IRVLDSNDNVPAF-DQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPR 296
Query: 507 ITSPFKINPNTGTVSVA------ESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVT 560
F ++P TG + V+ ESP+ + ++V+A D N + V ++
Sbjct: 297 ARELFGLSPRTGRLEVSGELDYEESPV----YQVYVQAKDLGPNAVPAHCKVLVRVLD-- 350
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
N P+I F G+ G ++ + D+ E V +LL VPF
Sbjct: 351 --ANDNAPEI-SFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELL----GDVPF 403
Query: 621 AVEER-SGVITVVDD--LSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVDVNDERGVL 676
++ T+V + L R Y VA LS + V V DVND
Sbjct: 404 RLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRF 463
Query: 677 LKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ----DVTDDIAI 732
+ + ++ + N GA I + T+ + + I Q V ++I
Sbjct: 464 SQPVYD--VYVTENNVPGAYIYAVSATDRDE---GANAQLAYSILECQIQGMSVFTYVSI 518
Query: 733 -AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVF---- 787
+E+G ++ + D E+ + V A + AG V I I D+NDN P
Sbjct: 519 NSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPL 578
Query: 788 --EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
+ T ++ S + + A DAD+G NA Y++ G +F +D TG
Sbjct: 579 PGRNGTPAREVLPRS--AEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRTG 636
Query: 845 VVKFIGD-SLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
++ R+ + Y+L + RD G LSS A L++ + D
Sbjct: 637 ELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVD 680
Score = 74.1 bits (174), Expect = 3e-12
Identities = 42/111 (37%), Positives = 61/111 (54%), Gaps = 7/111 (6%)
Query: 286 KTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+T A + I +LD NDN+P F+ Y +S+ EN P G V+Q+ ATD D+G+NGE Y
Sbjct: 230 RTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSF 289
Query: 346 D---DPKG--AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVV 391
P+ F + PR+G L V + LD E ++ V AK+ P+ V
Sbjct: 290 SSHISPRARELFGLSPRTGRLEVSGE--LDYEESPVYQVYVQAKDLGPNAV 338
Score = 62.5 bits (145), Expect = 1e-08
Identities = 49/179 (27%), Positives = 74/179 (41%), Gaps = 8/179 (4%)
Query: 218 IHAIDQDLGVGATLRYEL---ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
++A D D G + Y IS R+LF L G L + ELD + ++ + +
Sbjct: 272 LNATDPDEGQNGEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYE-----ESPVYQV 326
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
VQA L A +V + +LD NDN PE ++ E G V TD+D
Sbjct: 327 YVQAKDLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRD 386
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
ENG+ +L + T+ + LDREA S + V A++ + T
Sbjct: 387 SEENGQVQCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALST 445
Score = 61.7 bits (143), Expect = 2e-08
Identities = 63/223 (28%), Positives = 87/223 (39%), Gaps = 22/223 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ E GT + + D DS NGQ++ E +V P +L + K Y+ I
Sbjct: 367 VSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDV---PFRLKSS---FKNYYTI----- 415
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+ L E+ + L + A D G L+ + S++V V DVND+ P F + Y+ V
Sbjct: 416 --VTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVT 473
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYF-----IQPSDTDLPFEISPLTGVLSVNGELDR 1110
E + V ATD D G NA L Y IQ I+ G L D
Sbjct: 474 ENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSINSENGYLYALRSFDY 533
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYA 1153
E + V ARD G D NDN+P A
Sbjct: 534 EQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVA 576
Score = 58.8 bits (136), Expect = 1e-07
Identities = 73/293 (24%), Positives = 125/293 (42%), Gaps = 29/293 (9%)
Query: 71 GAGL---NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF-IFLIAPI-G 125
GAGL Q + +T+ + D NDNVP F Y V++ E +P G + P G
Sbjct: 221 GAGLPPQQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEG 280
Query: 126 PSLTIPLTV-----PRGLTIF----KDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALES 176
+ + + PR +F + R + + S V+ V D G A+ +
Sbjct: 281 QNGEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPA 340
Query: 177 SHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGATLR 232
H VL+ +VLD + E + ++ K E P + A+ D+D ++
Sbjct: 341 -HCKVLV--RVLDANDNAPE---ISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQ 394
Query: 233 YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV 292
EL+ +L S ++ E LD +A +++ L V A P + +
Sbjct: 395 CELLGDVPFRLKSSFKNYYTIVTEAPLDREA-----GDSYTLTVVARDRGEPALSTSKSI 449
Query: 293 EIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
++++ D+NDN P F Y++ + EN G + V ATD+D+G N + Y +
Sbjct: 450 QVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSI 502
Score = 57.6 bits (133), Expect = 3e-07
Identities = 45/162 (27%), Positives = 71/162 (43%), Gaps = 6/162 (3%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G + LD E+ VY++ V A+ + G + +V + + D NDN P +T +
Sbjct: 308 GRLEVSGELDYEESPVYQVYVQAK-DLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEA 366
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
+ E + GT + + ++ TD D N L G+ LDR
Sbjct: 367 VSEGAAPGTVVALFSV---TDRDSEENGQVQCELLGDVPFRLKSSFKNYYTIVTEAPLDR 423
Query: 856 EKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ 895
E Y L++VARD G LS+ + + + D NDN P F+Q
Sbjct: 424 EAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQ 465
Score = 57.6 bits (133), Expect = 3e-07
Identities = 55/204 (26%), Positives = 85/204 (41%), Gaps = 23/204 (11%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
+++ N+P G I ++A D D G N Q+ Y + + V Y IN
Sbjct: 470 VYVTENNVP-GAYIYAVSATDRDEGANAQLAYSI--------LECQIQGMSVFTYVSINS 520
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFKKTWYN 1051
+G++ RS E +F + A D G+ L N +V + + D ND+ P
Sbjct: 521 ENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPG 580
Query: 1052 FNVEEAQYTRR-------VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSV 1104
N A+ +L +V A DAD G+NA LTY I + F + TG L
Sbjct: 581 RNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRT 640
Query: 1105 NGEL--DRETEDKYILTVVARDNG 1126
+ R+ + Y L + RD+G
Sbjct: 641 ARRVPAKRDPQRPYELVIEVRDHG 664
Score = 54.0 bits (124), Expect = 4e-06
Identities = 77/336 (22%), Positives = 128/336 (38%), Gaps = 30/336 (8%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI----APIGPSL 128
G N + A+ V V + D NDN P + V E G +F + + +
Sbjct: 334 GPNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQV 393
Query: 129 TIPLT--VPRGL-TIFKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLL 184
L VP L + FK+ + P + Y++ V D G AL +S + +
Sbjct: 394 QCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQV 453
Query: 185 RKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKL- 243
V D + + + + ++ + A D+D G A L Y ++ + +
Sbjct: 454 SDVNDNAPRFSQPVYDVYVTENNVPGAYIYA--VSATDRDEGANAQLAYSILECQIQGMS 511
Query: 244 ----FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLD 298
S++S NG L+ + D + Q F QV+A +P A A V I ++D
Sbjct: 512 VFTYVSINSENGYLYALRSFDYE-----QLKDFSFQVEARDAGSPQALAGNATVNILIVD 566
Query: 299 LNDNLPEFEVDF---YNISIVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPK 349
NDN P E LP G+ + +V A D D GEN TY + +
Sbjct: 567 QNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEM 626
Query: 350 GAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
F +D R+G L + R+ + + ++
Sbjct: 627 NLFRMDWRTGELRTARRVPAKRDPQRPYELVIEVRD 662
Score = 49.2 bits (112), Expect = 1e-04
Identities = 41/139 (29%), Positives = 67/139 (48%), Gaps = 9/139 (6%)
Query: 221 IDQDLGVGATLR----YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
I +DLG+ T ++ + + L+ G L++ +++D + + Q+ + VL +
Sbjct: 37 IAEDLGLDITKLSARGFQTVPNSRTPYLDLNLETGVLYVNEKIDRE-QICKQSPSCVLHL 95
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+ L NPL+ Q VEIE+LD+NDN P F + I E+ G A D D G
Sbjct: 96 EVF-LENPLELFQ--VEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVG 152
Query: 337 ENGEFTYQLDDPKGAFSID 355
N Y++ P FS+D
Sbjct: 153 TNSLRDYEI-TPNSYFSLD 170
Score = 44.0 bits (99), Expect = 0.004
Identities = 41/151 (27%), Positives = 64/151 (42%), Gaps = 24/151 (15%)
Query: 1233 SSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKM 1290
+ TA+L + V D D V D+PV Y + + EN ++ LN T+ E N ++
Sbjct: 231 TGTALLTIRVLDSNDNVPAFDQPV-----YTVSLPENSPPGTLVIQLNATDPDEGQNGEV 285
Query: 1291 RYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYP 1350
Y + R F + PR G L + D E Y+V V+
Sbjct: 286 VYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQ---------------- 329
Query: 1351 VAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A+D+ KV+VR+ D NDN+P+ +
Sbjct: 330 -AKDLGPNAVPAHCKVLVRVLDANDNAPEIS 359
Score = 35.5 bits (78), Expect = 1.5
Identities = 35/113 (30%), Positives = 59/113 (52%), Gaps = 11/113 (9%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P+LS++ + V V+DV D +PV Y++ + EN + +++ T+ E
Sbjct: 439 GEPALSTSKSIQVQVSDVNDNAPRFSQPV-----YDVYVTENNVPGAYIYAVSATDRDEG 493
Query: 1287 -NFKMRYYILNENDTDIR-RTFV-IDPRNGTLYLVRSPDRE-VKD-TYEVIVR 1334
N ++ Y IL + T+V I+ NG LY +RS D E +KD +++V R
Sbjct: 494 ANAQLAYSILECQIQGMSVFTYVSINSENGYLYALRSFDYEQLKDFSFQVEAR 546
Score = 35.1 bits (77), Expect = 2.0
Identities = 82/374 (21%), Positives = 138/374 (36%), Gaps = 40/374 (10%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD-- 1088
V + V D+ND+ P F + + E+ A D D G N+ Y I P+
Sbjct: 108 VEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYF 167
Query: 1089 -TDLPFE-ISPLTGVLSVNGELDRETE--DKYILTVVARDNGXXXXXXXXXXXXXXXXDV 1144
D+ + L + LDRE + +Y+LT V G
Sbjct: 168 SLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQ 227
Query: 1145 NDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDT 1204
+ +L+ SN N + PVY ++ EN+P GT V ++ A D
Sbjct: 228 QQRTGTALLTIRVLD---------SNDNVPAFDQ-PVYTVSLPENSPPGTLVIQLNATDP 277
Query: 1205 DFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYEL 1264
D NG ++YS + + L LS + +V E++ + PV+
Sbjct: 278 D--EGQNGEVVYSFSSHISPRARELFGLSPRTGRL----EVSGELDYEESPVYQVYVQAK 331
Query: 1265 EIEENV-----NAPVELVSLNLTEHYENFKMRYYILNEN---DTDIRRTFVID---PRNG 1313
++ N V ++ N +F ++E T + V D NG
Sbjct: 332 DLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENG 391
Query: 1314 TL---YLVRSPDR---EVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVV 1367
+ L P R K+ Y ++ A + + + + + VA D E +
Sbjct: 392 QVQCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGD-SYTLTVVARDRGEPALSTSKSIQ 450
Query: 1368 VRIKDVNDNSPKFT 1381
V++ DVNDN+P+F+
Sbjct: 451 VQVSDVNDNAPRFS 464
Score = 34.3 bits (75), Expect = 3.4
Identities = 21/81 (25%), Positives = 40/81 (49%), Gaps = 3/81 (3%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A L Y ++ GN+ LF +D G L + + A+ + Q + L ++
Sbjct: 603 VAAVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRTARR--VPAKRDPQ-RPYELVIE 659
Query: 278 ASQLNNPLKTAQARVEIELLD 298
P ++ A + ++L+D
Sbjct: 660 VRDHGQPPLSSTATLVVQLVD 680
Score = 33.1 bits (72), Expect = 7.9
Identities = 23/93 (24%), Positives = 43/93 (46%), Gaps = 9/93 (9%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
+ L V + ++D NDN P V + +A+ G ++ +V AVD D G
Sbjct: 552 QALAGNATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDG 611
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVA 523
+N + Y + R + + + F+++ TG + A
Sbjct: 612 ENARLTYSIVRGNEMNL---FRMDWRTGELRTA 641
>AC105383-1|AAY41018.1| 1040|Homo sapiens unknown protein.
Length = 1040
Score = 111 bits (266), Expect = 2e-23
Identities = 120/429 (27%), Positives = 180/429 (41%), Gaps = 45/429 (10%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
E G ++ + +DRE+ + + + + ++QV I + D NDNPP F
Sbjct: 69 ETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELFQVEIEVLDINDNPPSFPEPDLT 128
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDV----DENTGVVKFI 849
I E++ GT +++ A D D GTN+L Y + DV D N +
Sbjct: 129 VEISESATPGTRFPLES---AFDPDVGTNSLRDYEITPNSYFSLDVQTQGDGNRFAELVL 185
Query: 850 GDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETK 909
LDRE++ +++ L A D GG +G+ + + +
Sbjct: 186 EKPLDREQQAVHRYVLTAVDGGGGGG-------VGEGGGG---------GGGAGLPPQQQ 229
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
GTA TI V N DQ +PEN P GT +I+LNA D D G NG++ Y
Sbjct: 230 RTGTALLTI-RVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYS 288
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALD-GGN-L 1025
F+S +I P + F ++ R G + V+ L E +++ + A D G N +
Sbjct: 289 FSS--HISP--------RARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAV 338
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
+ V V V D ND+ P + V E V+ TD D +N + +
Sbjct: 339 PAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELL 398
Query: 1086 PSDTDLPFEI-SPLTGVLSVNGE--LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXX 1142
D+PF + S ++ E LDRE D Y LTVVARD G
Sbjct: 399 ---GDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRG-EPALSTSKSIQVQVS 454
Query: 1143 DVNDNSPKF 1151
DVNDN+P+F
Sbjct: 455 DVNDNAPRF 463
Score = 108 bits (260), Expect = 1e-22
Identities = 125/494 (25%), Positives = 201/494 (40%), Gaps = 48/494 (9%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E + E + VE+ +LD NDN P F +L + +A GT A DPD+G
Sbjct: 94 HLEVFLENPLELFQVEIEVLDINDNPPSFPEPDL-TVEISESATPGTRFPLESAFDPDVG 152
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPAN--- 544
N + Y++ S ++ + + N V E P+ + H + A D
Sbjct: 153 TNSLRDYEITPNSYFSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGV 212
Query: 545 -------------PSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTS 591
P ++R A++TI V + ++P F Y + N GT
Sbjct: 213 GEGGGGGGGAGLPPQQQRTGTALLTIRVL----DSNDNVPAFDQPVYTVSLPENSPPGTL 268
Query: 592 VGQIRVNDAFE-QN-DVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEA 647
V Q+ D E QN +V Y F + R+G + V +L P+Y
Sbjct: 269 VIQLNATDPDEGQNGEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYV 328
Query: 648 VALQENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMS 706
A N + V V+D ND + + S + V E +A + +F
Sbjct: 329 QAKDLGPNAVPAHCKVLVRVLDANDNAPEI---SFSTVKEAVSEGAAPGTVVALFSVTDR 385
Query: 707 SIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVIS 766
NG V+ + + TI T+ PLDRE D Y +TV+A ++G +
Sbjct: 386 DSEENG--QVQCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVAR-DRGEPA 442
Query: 767 GAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFM 826
+ + + + D NDN P F Y+ ++ EN+ G I + ATD DEG NA
Sbjct: 443 LSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYA---VSATDRDEGANAQLA 499
Query: 827 YTLFG---EGKEMF---DVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG---LSSEA 877
Y++ +G +F ++ G + + S D E+ + + ARD G L+ A
Sbjct: 500 YSILECQIQGMSVFTYVSINSENGYLYALR-SFDYEQLKDFSFQVEARDAGSPQALAGNA 558
Query: 878 ELIIMIGDENDNKP 891
+ I+I D+NDN P
Sbjct: 559 TVNILIVDQNDNAP 572
Score = 87.0 bits (206), Expect = 5e-16
Identities = 116/464 (25%), Positives = 191/464 (41%), Gaps = 46/464 (9%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLT 506
+ +LD+NDN P F +Y S+ N+ GT++ ++ A DPD GQNG V+Y +
Sbjct: 238 IRVLDSNDNVPAF-DQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPR 296
Query: 507 ITSPFKINPNTGTVSVA------ESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVT 560
F ++P TG + V+ ESP+ + ++V+A D N + V ++
Sbjct: 297 ARELFGLSPRTGRLEVSGELDYEESPV----YQVYVQAKDLGPNAVPAHCKVLVRVLD-- 350
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
N P+I F G+ G ++ + D+ E V +LL VPF
Sbjct: 351 --ANDNAPEI-SFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELL----GDVPF 403
Query: 621 AVEER-SGVITVVDD--LSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVDVNDERGVL 676
++ T+V + L R Y VA LS + V V DVND
Sbjct: 404 RLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRF 463
Query: 677 LKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ----DVTDDIAI 732
+ + ++ + N GA I + T+ + + I Q V ++I
Sbjct: 464 SQPVYD--VYVTENNVPGAYIYAVSATDRDE---GANAQLAYSILECQIQGMSVFTYVSI 518
Query: 733 -AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVF---- 787
+E+G ++ + D E+ + V A + AG V I I D+NDN P
Sbjct: 519 NSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPL 578
Query: 788 --EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
+ T ++ S + + A DAD+G NA Y++ G +F +D TG
Sbjct: 579 PGRNGTPAREVLPRS--AEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRTG 636
Query: 845 VVKFIGD-SLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
++ R+ + Y+L + RD G LSS A L++ + D
Sbjct: 637 ELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVD 680
Score = 74.1 bits (174), Expect = 3e-12
Identities = 42/111 (37%), Positives = 61/111 (54%), Gaps = 7/111 (6%)
Query: 286 KTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+T A + I +LD NDN+P F+ Y +S+ EN P G V+Q+ ATD D+G+NGE Y
Sbjct: 230 RTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSF 289
Query: 346 D---DPKG--AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVV 391
P+ F + PR+G L V + LD E ++ V AK+ P+ V
Sbjct: 290 SSHISPRARELFGLSPRTGRLEVSGE--LDYEESPVYQVYVQAKDLGPNAV 338
Score = 62.5 bits (145), Expect = 1e-08
Identities = 49/179 (27%), Positives = 74/179 (41%), Gaps = 8/179 (4%)
Query: 218 IHAIDQDLGVGATLRYEL---ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
++A D D G + Y IS R+LF L G L + ELD + ++ + +
Sbjct: 272 LNATDPDEGQNGEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYE-----ESPVYQV 326
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
VQA L A +V + +LD NDN PE ++ E G V TD+D
Sbjct: 327 YVQAKDLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRD 386
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
ENG+ +L + T+ + LDREA S + V A++ + T
Sbjct: 387 SEENGQVQCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALST 445
Score = 61.7 bits (143), Expect = 2e-08
Identities = 63/223 (28%), Positives = 87/223 (39%), Gaps = 22/223 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ E GT + + D DS NGQ++ E +V P +L + K Y+ I
Sbjct: 367 VSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDV---PFRLKSS---FKNYYTI----- 415
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+ L E+ + L + A D G L+ + S++V V DVND+ P F + Y+ V
Sbjct: 416 --VTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVT 473
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYF-----IQPSDTDLPFEISPLTGVLSVNGELDR 1110
E + V ATD D G NA L Y IQ I+ G L D
Sbjct: 474 ENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSINSENGYLYALRSFDY 533
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYA 1153
E + V ARD G D NDN+P A
Sbjct: 534 EQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVA 576
Score = 58.8 bits (136), Expect = 1e-07
Identities = 73/293 (24%), Positives = 125/293 (42%), Gaps = 29/293 (9%)
Query: 71 GAGL---NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF-IFLIAPI-G 125
GAGL Q + +T+ + D NDNVP F Y V++ E +P G + P G
Sbjct: 221 GAGLPPQQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEG 280
Query: 126 PSLTIPLTV-----PRGLTIF----KDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALES 176
+ + + PR +F + R + + S V+ V D G A+ +
Sbjct: 281 QNGEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPA 340
Query: 177 SHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGATLR 232
H VL+ +VLD + E + ++ K E P + A+ D+D ++
Sbjct: 341 -HCKVLV--RVLDANDNAPE---ISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQ 394
Query: 233 YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV 292
EL+ +L S ++ E LD +A +++ L V A P + +
Sbjct: 395 CELLGDVPFRLKSSFKNYYTIVTEAPLDREA-----GDSYTLTVVARDRGEPALSTSKSI 449
Query: 293 EIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
++++ D+NDN P F Y++ + EN G + V ATD+D+G N + Y +
Sbjct: 450 QVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSI 502
Score = 57.6 bits (133), Expect = 3e-07
Identities = 45/162 (27%), Positives = 71/162 (43%), Gaps = 6/162 (3%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G + LD E+ VY++ V A+ + G + +V + + D NDN P +T +
Sbjct: 308 GRLEVSGELDYEESPVYQVYVQAK-DLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEA 366
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
+ E + GT + + ++ TD D N L G+ LDR
Sbjct: 367 VSEGAAPGTVVALFSV---TDRDSEENGQVQCELLGDVPFRLKSSFKNYYTIVTEAPLDR 423
Query: 856 EKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ 895
E Y L++VARD G LS+ + + + D NDN P F+Q
Sbjct: 424 EAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQ 465
Score = 57.6 bits (133), Expect = 3e-07
Identities = 55/204 (26%), Positives = 85/204 (41%), Gaps = 23/204 (11%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
+++ N+P G I ++A D D G N Q+ Y + + V Y IN
Sbjct: 470 VYVTENNVP-GAYIYAVSATDRDEGANAQLAYSI--------LECQIQGMSVFTYVSINS 520
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFKKTWYN 1051
+G++ RS E +F + A D G+ L N +V + + D ND+ P
Sbjct: 521 ENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPG 580
Query: 1052 FNVEEAQYTRR-------VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSV 1104
N A+ +L +V A DAD G+NA LTY I + F + TG L
Sbjct: 581 RNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRT 640
Query: 1105 NGEL--DRETEDKYILTVVARDNG 1126
+ R+ + Y L + RD+G
Sbjct: 641 ARRVPAKRDPQRPYELVIEVRDHG 664
Score = 54.0 bits (124), Expect = 4e-06
Identities = 77/336 (22%), Positives = 128/336 (38%), Gaps = 30/336 (8%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI----APIGPSL 128
G N + A+ V V + D NDN P + V E G +F + + +
Sbjct: 334 GPNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQV 393
Query: 129 TIPLT--VPRGL-TIFKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLL 184
L VP L + FK+ + P + Y++ V D G AL +S + +
Sbjct: 394 QCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQV 453
Query: 185 RKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKL- 243
V D + + + + ++ + A D+D G A L Y ++ + +
Sbjct: 454 SDVNDNAPRFSQPVYDVYVTENNVPGAYIYA--VSATDRDEGANAQLAYSILECQIQGMS 511
Query: 244 ----FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLD 298
S++S NG L+ + D + Q F QV+A +P A A V I ++D
Sbjct: 512 VFTYVSINSENGYLYALRSFDYE-----QLKDFSFQVEARDAGSPQALAGNATVNILIVD 566
Query: 299 LNDNLPEFEVDF---YNISIVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPK 349
NDN P E LP G+ + +V A D D GEN TY + +
Sbjct: 567 QNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEM 626
Query: 350 GAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
F +D R+G L + R+ + + ++
Sbjct: 627 NLFRMDWRTGELRTARRVPAKRDPQRPYELVIEVRD 662
Score = 49.2 bits (112), Expect = 1e-04
Identities = 41/139 (29%), Positives = 67/139 (48%), Gaps = 9/139 (6%)
Query: 221 IDQDLGVGATLR----YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
I +DLG+ T ++ + + L+ G L++ +++D + + Q+ + VL +
Sbjct: 37 IAEDLGLDITKLSARGFQTVPNSRTPYLDLNLETGVLYVNEKIDRE-QICKQSPSCVLHL 95
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+ L NPL+ Q VEIE+LD+NDN P F + I E+ G A D D G
Sbjct: 96 EVF-LENPLELFQ--VEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVG 152
Query: 337 ENGEFTYQLDDPKGAFSID 355
N Y++ P FS+D
Sbjct: 153 TNSLRDYEI-TPNSYFSLD 170
Score = 44.0 bits (99), Expect = 0.004
Identities = 41/151 (27%), Positives = 64/151 (42%), Gaps = 24/151 (15%)
Query: 1233 SSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKM 1290
+ TA+L + V D D V D+PV Y + + EN ++ LN T+ E N ++
Sbjct: 231 TGTALLTIRVLDSNDNVPAFDQPV-----YTVSLPENSPPGTLVIQLNATDPDEGQNGEV 285
Query: 1291 RYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYP 1350
Y + R F + PR G L + D E Y+V V+
Sbjct: 286 VYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQ---------------- 329
Query: 1351 VAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A+D+ KV+VR+ D NDN+P+ +
Sbjct: 330 -AKDLGPNAVPAHCKVLVRVLDANDNAPEIS 359
Score = 35.5 bits (78), Expect = 1.5
Identities = 35/113 (30%), Positives = 59/113 (52%), Gaps = 11/113 (9%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P+LS++ + V V+DV D +PV Y++ + EN + +++ T+ E
Sbjct: 439 GEPALSTSKSIQVQVSDVNDNAPRFSQPV-----YDVYVTENNVPGAYIYAVSATDRDEG 493
Query: 1287 -NFKMRYYILNENDTDIR-RTFV-IDPRNGTLYLVRSPDRE-VKD-TYEVIVR 1334
N ++ Y IL + T+V I+ NG LY +RS D E +KD +++V R
Sbjct: 494 ANAQLAYSILECQIQGMSVFTYVSINSENGYLYALRSFDYEQLKDFSFQVEAR 546
Score = 35.1 bits (77), Expect = 2.0
Identities = 82/374 (21%), Positives = 138/374 (36%), Gaps = 40/374 (10%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD-- 1088
V + V D+ND+ P F + + E+ A D D G N+ Y I P+
Sbjct: 108 VEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYF 167
Query: 1089 -TDLPFE-ISPLTGVLSVNGELDRETE--DKYILTVVARDNGXXXXXXXXXXXXXXXXDV 1144
D+ + L + LDRE + +Y+LT V G
Sbjct: 168 SLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQ 227
Query: 1145 NDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDT 1204
+ +L+ SN N + PVY ++ EN+P GT V ++ A D
Sbjct: 228 QQRTGTALLTIRVLD---------SNDNVPAFDQ-PVYTVSLPENSPPGTLVIQLNATDP 277
Query: 1205 DFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYEL 1264
D NG ++YS + + L LS + +V E++ + PV+
Sbjct: 278 D--EGQNGEVVYSFSSHISPRARELFGLSPRTGRL----EVSGELDYEESPVYQVYVQAK 331
Query: 1265 EIEENV-----NAPVELVSLNLTEHYENFKMRYYILNEN---DTDIRRTFVID---PRNG 1313
++ N V ++ N +F ++E T + V D NG
Sbjct: 332 DLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENG 391
Query: 1314 TL---YLVRSPDR---EVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVV 1367
+ L P R K+ Y ++ A + + + + + VA D E +
Sbjct: 392 QVQCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGD-SYTLTVVARDRGEPALSTSKSIQ 450
Query: 1368 VRIKDVNDNSPKFT 1381
V++ DVNDN+P+F+
Sbjct: 451 VQVSDVNDNAPRFS 464
Score = 34.3 bits (75), Expect = 3.4
Identities = 21/81 (25%), Positives = 40/81 (49%), Gaps = 3/81 (3%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A L Y ++ GN+ LF +D G L + + A+ + Q + L ++
Sbjct: 603 VAAVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRTARR--VPAKRDPQ-RPYELVIE 659
Query: 278 ASQLNNPLKTAQARVEIELLD 298
P ++ A + ++L+D
Sbjct: 660 VRDHGQPPLSSTATLVVQLVD 680
Score = 33.1 bits (72), Expect = 7.9
Identities = 23/93 (24%), Positives = 43/93 (46%), Gaps = 9/93 (9%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
+ L V + ++D NDN P V + +A+ G ++ +V AVD D G
Sbjct: 552 QALAGNATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDG 611
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVA 523
+N + Y + R + + + F+++ TG + A
Sbjct: 612 ENARLTYSIVRGNEMNL---FRMDWRTGELRTA 641
>AB037821-1|BAA92638.1| 1093|Homo sapiens KIAA1400 protein protein.
Length = 1093
Score = 111 bits (266), Expect = 2e-23
Identities = 120/429 (27%), Positives = 180/429 (41%), Gaps = 45/429 (10%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
E G ++ + +DRE+ + + + + ++QV I + D NDNPP F
Sbjct: 122 ETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELFQVEIEVLDINDNPPSFPEPDLT 181
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDV----DENTGVVKFI 849
I E++ GT +++ A D D GTN+L Y + DV D N +
Sbjct: 182 VEISESATPGTRFPLES---AFDPDVGTNSLRDYEITPNSYFSLDVQTQGDGNRFAELVL 238
Query: 850 GDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETK 909
LDRE++ +++ L A D GG +G+ + + +
Sbjct: 239 EKPLDREQQAVHRYVLTAVDGGGGGG-------VGEGGGG---------GGGAGLPPQQQ 282
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
GTA TI V N DQ +PEN P GT +I+LNA D D G NG++ Y
Sbjct: 283 RTGTALLTI-RVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYS 341
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALD-GGN-L 1025
F+S +I P + F ++ R G + V+ L E +++ + A D G N +
Sbjct: 342 FSS--HISP--------RARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAV 391
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
+ V V V D ND+ P + V E V+ TD D +N + +
Sbjct: 392 PAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELL 451
Query: 1086 PSDTDLPFEI-SPLTGVLSVNGE--LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXX 1142
D+PF + S ++ E LDRE D Y LTVVARD G
Sbjct: 452 ---GDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRG-EPALSTSKSIQVQVS 507
Query: 1143 DVNDNSPKF 1151
DVNDN+P+F
Sbjct: 508 DVNDNAPRF 516
Score = 108 bits (260), Expect = 1e-22
Identities = 125/494 (25%), Positives = 201/494 (40%), Gaps = 48/494 (9%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E + E + VE+ +LD NDN P F +L + +A GT A DPD+G
Sbjct: 147 HLEVFLENPLELFQVEIEVLDINDNPPSFPEPDL-TVEISESATPGTRFPLESAFDPDVG 205
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPAN--- 544
N + Y++ S ++ + + N V E P+ + H + A D
Sbjct: 206 TNSLRDYEITPNSYFSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGV 265
Query: 545 -------------PSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTS 591
P ++R A++TI V + ++P F Y + N GT
Sbjct: 266 GEGGGGGGGAGLPPQQQRTGTALLTIRVL----DSNDNVPAFDQPVYTVSLPENSPPGTL 321
Query: 592 VGQIRVNDAFE-QN-DVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEA 647
V Q+ D E QN +V Y F + R+G + V +L P+Y
Sbjct: 322 VIQLNATDPDEGQNGEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYV 381
Query: 648 VALQENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMS 706
A N + V V+D ND + + S + V E +A + +F
Sbjct: 382 QAKDLGPNAVPAHCKVLVRVLDANDNAPEI---SFSTVKEAVSEGAAPGTVVALFSVTDR 438
Query: 707 SIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVIS 766
NG V+ + + TI T+ PLDRE D Y +TV+A ++G +
Sbjct: 439 DSEENG--QVQCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVAR-DRGEPA 495
Query: 767 GAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFM 826
+ + + + D NDN P F Y+ ++ EN+ G I + ATD DEG NA
Sbjct: 496 LSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYA---VSATDRDEGANAQLA 552
Query: 827 YTLFG---EGKEMF---DVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG---LSSEA 877
Y++ +G +F ++ G + + S D E+ + + ARD G L+ A
Sbjct: 553 YSILECQIQGMSVFTYVSINSENGYLYALR-SFDYEQLKDFSFQVEARDAGSPQALAGNA 611
Query: 878 ELIIMIGDENDNKP 891
+ I+I D+NDN P
Sbjct: 612 TVNILIVDQNDNAP 625
Score = 87.0 bits (206), Expect = 5e-16
Identities = 116/464 (25%), Positives = 191/464 (41%), Gaps = 46/464 (9%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLT 506
+ +LD+NDN P F +Y S+ N+ GT++ ++ A DPD GQNG V+Y +
Sbjct: 291 IRVLDSNDNVPAF-DQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPR 349
Query: 507 ITSPFKINPNTGTVSVA------ESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVT 560
F ++P TG + V+ ESP+ + ++V+A D N + V ++
Sbjct: 350 ARELFGLSPRTGRLEVSGELDYEESPV----YQVYVQAKDLGPNAVPAHCKVLVRVLD-- 403
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
N P+I F G+ G ++ + D+ E V +LL VPF
Sbjct: 404 --ANDNAPEI-SFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELL----GDVPF 456
Query: 621 AVEER-SGVITVVDD--LSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVDVNDERGVL 676
++ T+V + L R Y VA LS + V V DVND
Sbjct: 457 RLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRF 516
Query: 677 LKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ----DVTDDIAI 732
+ + ++ + N GA I + T+ + + I Q V ++I
Sbjct: 517 SQPVYD--VYVTENNVPGAYIYAVSATDRDE---GANAQLAYSILECQIQGMSVFTYVSI 571
Query: 733 -AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVF---- 787
+E+G ++ + D E+ + V A + AG V I I D+NDN P
Sbjct: 572 NSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPL 631
Query: 788 --EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
+ T ++ S + + A DAD+G NA Y++ G +F +D TG
Sbjct: 632 PGRNGTPAREVLPRS--AEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRTG 689
Query: 845 VVKFIGD-SLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
++ R+ + Y+L + RD G LSS A L++ + D
Sbjct: 690 ELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVD 733
Score = 74.1 bits (174), Expect = 3e-12
Identities = 42/111 (37%), Positives = 61/111 (54%), Gaps = 7/111 (6%)
Query: 286 KTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+T A + I +LD NDN+P F+ Y +S+ EN P G V+Q+ ATD D+G+NGE Y
Sbjct: 283 RTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSF 342
Query: 346 D---DPKG--AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVV 391
P+ F + PR+G L V + LD E ++ V AK+ P+ V
Sbjct: 343 SSHISPRARELFGLSPRTGRLEVSGE--LDYEESPVYQVYVQAKDLGPNAV 391
Score = 62.5 bits (145), Expect = 1e-08
Identities = 49/179 (27%), Positives = 74/179 (41%), Gaps = 8/179 (4%)
Query: 218 IHAIDQDLGVGATLRYEL---ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
++A D D G + Y IS R+LF L G L + ELD + ++ + +
Sbjct: 325 LNATDPDEGQNGEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYE-----ESPVYQV 379
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
VQA L A +V + +LD NDN PE ++ E G V TD+D
Sbjct: 380 YVQAKDLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRD 439
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
ENG+ +L + T+ + LDREA S + V A++ + T
Sbjct: 440 SEENGQVQCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALST 498
Score = 61.7 bits (143), Expect = 2e-08
Identities = 63/223 (28%), Positives = 87/223 (39%), Gaps = 22/223 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ E GT + + D DS NGQ++ E +V P +L + K Y+ I
Sbjct: 420 VSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDV---PFRLKSS---FKNYYTI----- 468
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+ L E+ + L + A D G L+ + S++V V DVND+ P F + Y+ V
Sbjct: 469 --VTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVT 526
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYF-----IQPSDTDLPFEISPLTGVLSVNGELDR 1110
E + V ATD D G NA L Y IQ I+ G L D
Sbjct: 527 ENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSINSENGYLYALRSFDY 586
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYA 1153
E + V ARD G D NDN+P A
Sbjct: 587 EQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVA 629
Score = 58.8 bits (136), Expect = 1e-07
Identities = 73/293 (24%), Positives = 125/293 (42%), Gaps = 29/293 (9%)
Query: 71 GAGL---NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF-IFLIAPI-G 125
GAGL Q + +T+ + D NDNVP F Y V++ E +P G + P G
Sbjct: 274 GAGLPPQQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEG 333
Query: 126 PSLTIPLTV-----PRGLTIF----KDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALES 176
+ + + PR +F + R + + S V+ V D G A+ +
Sbjct: 334 QNGEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPA 393
Query: 177 SHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGATLR 232
H VL+ +VLD + E + ++ K E P + A+ D+D ++
Sbjct: 394 -HCKVLV--RVLDANDNAPE---ISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQ 447
Query: 233 YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV 292
EL+ +L S ++ E LD +A +++ L V A P + +
Sbjct: 448 CELLGDVPFRLKSSFKNYYTIVTEAPLDREA-----GDSYTLTVVARDRGEPALSTSKSI 502
Query: 293 EIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
++++ D+NDN P F Y++ + EN G + V ATD+D+G N + Y +
Sbjct: 503 QVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSI 555
Score = 57.6 bits (133), Expect = 3e-07
Identities = 45/162 (27%), Positives = 71/162 (43%), Gaps = 6/162 (3%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G + LD E+ VY++ V A+ + G + +V + + D NDN P +T +
Sbjct: 361 GRLEVSGELDYEESPVYQVYVQAK-DLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEA 419
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
+ E + GT + + ++ TD D N L G+ LDR
Sbjct: 420 VSEGAAPGTVVALFSV---TDRDSEENGQVQCELLGDVPFRLKSSFKNYYTIVTEAPLDR 476
Query: 856 EKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ 895
E Y L++VARD G LS+ + + + D NDN P F+Q
Sbjct: 477 EAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQ 518
Score = 57.6 bits (133), Expect = 3e-07
Identities = 55/204 (26%), Positives = 85/204 (41%), Gaps = 23/204 (11%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
+++ N+P G I ++A D D G N Q+ Y + + V Y IN
Sbjct: 523 VYVTENNVP-GAYIYAVSATDRDEGANAQLAYSI--------LECQIQGMSVFTYVSINS 573
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFKKTWYN 1051
+G++ RS E +F + A D G+ L N +V + + D ND+ P
Sbjct: 574 ENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPG 633
Query: 1052 FNVEEAQYTRR-------VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSV 1104
N A+ +L +V A DAD G+NA LTY I + F + TG L
Sbjct: 634 RNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRT 693
Query: 1105 NGEL--DRETEDKYILTVVARDNG 1126
+ R+ + Y L + RD+G
Sbjct: 694 ARRVPAKRDPQRPYELVIEVRDHG 717
Score = 54.0 bits (124), Expect = 4e-06
Identities = 77/336 (22%), Positives = 128/336 (38%), Gaps = 30/336 (8%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI----APIGPSL 128
G N + A+ V V + D NDN P + V E G +F + + +
Sbjct: 387 GPNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQV 446
Query: 129 TIPLT--VPRGL-TIFKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLL 184
L VP L + FK+ + P + Y++ V D G AL +S + +
Sbjct: 447 QCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQV 506
Query: 185 RKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKL- 243
V D + + + + ++ + A D+D G A L Y ++ + +
Sbjct: 507 SDVNDNAPRFSQPVYDVYVTENNVPGAYIYA--VSATDRDEGANAQLAYSILECQIQGMS 564
Query: 244 ----FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLD 298
S++S NG L+ + D + Q F QV+A +P A A V I ++D
Sbjct: 565 VFTYVSINSENGYLYALRSFDYE-----QLKDFSFQVEARDAGSPQALAGNATVNILIVD 619
Query: 299 LNDNLPEFEVDF---YNISIVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPK 349
NDN P E LP G+ + +V A D D GEN TY + +
Sbjct: 620 QNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEM 679
Query: 350 GAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
F +D R+G L + R+ + + ++
Sbjct: 680 NLFRMDWRTGELRTARRVPAKRDPQRPYELVIEVRD 715
Score = 49.2 bits (112), Expect = 1e-04
Identities = 41/139 (29%), Positives = 67/139 (48%), Gaps = 9/139 (6%)
Query: 221 IDQDLGVGATLR----YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
I +DLG+ T ++ + + L+ G L++ +++D + + Q+ + VL +
Sbjct: 90 IAEDLGLDITKLSARGFQTVPNSRTPYLDLNLETGVLYVNEKIDRE-QICKQSPSCVLHL 148
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+ L NPL+ Q VEIE+LD+NDN P F + I E+ G A D D G
Sbjct: 149 EVF-LENPLELFQ--VEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVG 205
Query: 337 ENGEFTYQLDDPKGAFSID 355
N Y++ P FS+D
Sbjct: 206 TNSLRDYEI-TPNSYFSLD 223
Score = 44.0 bits (99), Expect = 0.004
Identities = 41/151 (27%), Positives = 64/151 (42%), Gaps = 24/151 (15%)
Query: 1233 SSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKM 1290
+ TA+L + V D D V D+PV Y + + EN ++ LN T+ E N ++
Sbjct: 284 TGTALLTIRVLDSNDNVPAFDQPV-----YTVSLPENSPPGTLVIQLNATDPDEGQNGEV 338
Query: 1291 RYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYP 1350
Y + R F + PR G L + D E Y+V V+
Sbjct: 339 VYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQ---------------- 382
Query: 1351 VAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A+D+ KV+VR+ D NDN+P+ +
Sbjct: 383 -AKDLGPNAVPAHCKVLVRVLDANDNAPEIS 412
Score = 35.5 bits (78), Expect = 1.5
Identities = 35/113 (30%), Positives = 59/113 (52%), Gaps = 11/113 (9%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P+LS++ + V V+DV D +PV Y++ + EN + +++ T+ E
Sbjct: 492 GEPALSTSKSIQVQVSDVNDNAPRFSQPV-----YDVYVTENNVPGAYIYAVSATDRDEG 546
Query: 1287 -NFKMRYYILNENDTDIR-RTFV-IDPRNGTLYLVRSPDRE-VKD-TYEVIVR 1334
N ++ Y IL + T+V I+ NG LY +RS D E +KD +++V R
Sbjct: 547 ANAQLAYSILECQIQGMSVFTYVSINSENGYLYALRSFDYEQLKDFSFQVEAR 599
Score = 35.1 bits (77), Expect = 2.0
Identities = 82/374 (21%), Positives = 138/374 (36%), Gaps = 40/374 (10%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD-- 1088
V + V D+ND+ P F + + E+ A D D G N+ Y I P+
Sbjct: 161 VEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYF 220
Query: 1089 -TDLPFE-ISPLTGVLSVNGELDRETE--DKYILTVVARDNGXXXXXXXXXXXXXXXXDV 1144
D+ + L + LDRE + +Y+LT V G
Sbjct: 221 SLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQ 280
Query: 1145 NDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDT 1204
+ +L+ SN N + PVY ++ EN+P GT V ++ A D
Sbjct: 281 QQRTGTALLTIRVLD---------SNDNVPAFDQ-PVYTVSLPENSPPGTLVIQLNATDP 330
Query: 1205 DFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYEL 1264
D NG ++YS + + L LS + +V E++ + PV+
Sbjct: 331 D--EGQNGEVVYSFSSHISPRARELFGLSPRTGRL----EVSGELDYEESPVYQVYVQAK 384
Query: 1265 EIEENV-----NAPVELVSLNLTEHYENFKMRYYILNEN---DTDIRRTFVID---PRNG 1313
++ N V ++ N +F ++E T + V D NG
Sbjct: 385 DLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENG 444
Query: 1314 TL---YLVRSPDR---EVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVV 1367
+ L P R K+ Y ++ A + + + + + VA D E +
Sbjct: 445 QVQCELLGDVPFRLKSSFKNYYTIVTEAPLDREAGD-SYTLTVVARDRGEPALSTSKSIQ 503
Query: 1368 VRIKDVNDNSPKFT 1381
V++ DVNDN+P+F+
Sbjct: 504 VQVSDVNDNAPRFS 517
Score = 34.3 bits (75), Expect = 3.4
Identities = 21/81 (25%), Positives = 40/81 (49%), Gaps = 3/81 (3%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A L Y ++ GN+ LF +D G L + + A+ + Q + L ++
Sbjct: 656 VAAVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRTARR--VPAKRDPQ-RPYELVIE 712
Query: 278 ASQLNNPLKTAQARVEIELLD 298
P ++ A + ++L+D
Sbjct: 713 VRDHGQPPLSSTATLVVQLVD 733
Score = 33.1 bits (72), Expect = 7.9
Identities = 23/93 (24%), Positives = 43/93 (46%), Gaps = 9/93 (9%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
+ L V + ++D NDN P V + +A+ G ++ +V AVD D G
Sbjct: 605 QALAGNATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDG 664
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVA 523
+N + Y + R + + + F+++ TG + A
Sbjct: 665 ENARLTYSIVRGNEMNL---FRMDWRTGELRTA 694
>BC113607-1|AAI13608.1| 803|Homo sapiens protocadherin gamma
subfamily B, 4 protein.
Length = 803
Score = 110 bits (265), Expect = 3e-23
Identities = 120/471 (25%), Positives = 206/471 (43%), Gaps = 39/471 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E ++F +V V + D ND+ P F N +E + +A+ GT A D D+G N +
Sbjct: 111 ENPLNFYHVNVEIEDINDHTPKFT-QNSFELQISESAQPGTRFILGSAHDADIGSNTLQN 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLA 553
Y L + + ++ + K + + V ++P+ + + L + A D A P S A
Sbjct: 170 YQLSPSDHFSLINKEKSDGSKYPEMVLKTPLDREKQKSYHLTLTALDFGAPPLS---STA 226
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHG 613
+ + VT + P F Y + NV GT+V Q+ D + V+ ++
Sbjct: 227 QIHVLVTDAND----NAPVFSQDVYRVSLSENVYPGTTVLQVTATD--QDEGVNAEITFS 280
Query: 614 YEEG---VPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
+ E F + +G ITV++ L Y A ++ + V V+D N
Sbjct: 281 FSEASQITQFDLNSNTGEITVLNTLDFEEVKEYSIVLEA-RDGGGMIAQCTVEVEVIDEN 339
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
D ++ + +I +++ G I + + S + NG + + DV I
Sbjct: 340 DNAPEVIFQSLPNLI--MEDAELGTHIALLKVRDKDSRH-NGEVTCKL----EGDVPFKI 392
Query: 731 AIAEDGT--IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ T + T LDRE+ Y +TV A ++G + +T++I D NDN PVF
Sbjct: 393 LTSSRNTYKLVTDAVLDREQNPEYNITVTAT-DRGKPPLSSSSSITLHIGDVNDNAPVFS 451
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEM---FDVDEN 842
++Y + EN+ G I ++A+D D G N Y + E +E+ +
Sbjct: 452 QSSYIVHVAENNPPGASISQ---VRASDPDLGPNGQVSYCIMASDLEQRELSSYVSISAE 508
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
+GVV F + D E+ ++L+L ARD G LS+ L +++ D NDN P
Sbjct: 509 SGVV-FAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVDDRNDNAP 558
Score = 94.3 bits (224), Expect = 3e-18
Identities = 86/314 (27%), Positives = 141/314 (44%), Gaps = 23/314 (7%)
Query: 589 GTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN----RPMYD 644
G+ VG + + F ++ L E F V SG + V L R +P
Sbjct: 44 GSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVSAESGELLVSSRLDREEICGKKPACA 103
Query: 645 FEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTN 704
E A+ EN L+ + V + D+ND + + I + +G +
Sbjct: 104 LEFEAVAENP-LNFY-HVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILGSAHDAD 161
Query: 705 MSSIYGNG---TGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIA-EF 760
+ S + + F + N++ +D E + + PLDREK+ Y +T+ A +F
Sbjct: 162 IGSNTLQNYQLSPSDHFSLINKEK-SDGSKYPE---MVLKTPLDREKQKSYHLTLTALDF 217
Query: 761 NKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEG 820
+S Q+ + + D NDN PVF Y + EN GT + + ATD DEG
Sbjct: 218 GAPPLSSTA--QIHVLVTDANDNAPVFSQDVYRVSLSENVYPGTTVLQ---VTATDQDEG 272
Query: 821 TNALFMYTLFGEGKEM--FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAE 878
NA ++ F E ++ FD++ NTG + + ++LD E+ Y + L ARD GG+ ++
Sbjct: 273 VNAEITFS-FSEASQITQFDLNSNTGEITVL-NTLDFEEVKEYSIVLEARDGGGMIAQCT 330
Query: 879 LIIMIGDENDNKPE 892
+ + + DENDN PE
Sbjct: 331 VEVEVIDENDNAPE 344
Score = 77.4 bits (182), Expect = 4e-13
Identities = 45/148 (30%), Positives = 74/148 (50%), Gaps = 3/148 (2%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D+G Y+L + L + + +GS + E L + Q ++ L + A
Sbjct: 157 AHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYPEMVLKTPLDREKQ-KSYHLTLTAL 215
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
P ++ A++ + + D NDN P F D Y +S+ EN+ G +VLQV ATD+D+G N
Sbjct: 216 DFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVSLSENVYPGTTVLQVTATDQDEGVNA 275
Query: 340 EFTYQLDDPK--GAFSIDPRSGWLTVRN 365
E T+ + F ++ +G +TV N
Sbjct: 276 EITFSFSEASQITQFDLNSNTGEITVLN 303
Score = 75.8 bits (178), Expect = 1e-12
Identities = 56/169 (33%), Positives = 81/169 (47%), Gaps = 9/169 (5%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
AE G + LDRE+ + EF + Y V + IED ND+ P F ++
Sbjct: 79 AESGELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSF 138
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF---- 848
E I E+++ GT + + A DAD G+N L Y L E + K+
Sbjct: 139 ELQISESAQPGTRFILGS---AHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYPEMV 195
Query: 849 IGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+ LDREK+ Y L+L A D G LSS A++ +++ D NDN P F+Q
Sbjct: 196 LKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQ 244
Score = 75.8 bits (178), Expect = 1e-12
Identities = 98/415 (23%), Positives = 172/415 (41%), Gaps = 37/415 (8%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I E+ GT I +A D D G N Y+ + + S ++ + + +Y
Sbjct: 142 ISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHF--SLINKEKSDGSKY-------P 192
Query: 1000 HVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+++ L E + + L ++ALD G L+ + V V D ND+ PVF + Y ++
Sbjct: 193 EMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVSLS 252
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E Y + +V ATD D G NA +T+ + F+++ TG ++V LD E +
Sbjct: 253 ENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDLNSNTGEITVLNTLDFEEVKE 312
Query: 1116 YILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH---- 1171
Y + + ARD G D NDN+P+ F L +A EL H
Sbjct: 313 YSIVLEARDGG---GMIAQCTVEVEVIDENDNAPE-VIFQSLPNLIMEDA-ELGTHIALL 367
Query: 1172 --NFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL 1227
+ +E + P I T+ + TD + + Y++ +
Sbjct: 368 KVRDKDSRHNGEVTCKLEGDVPFKILTSSRNTYKLVTDAVLDREQNPEYNITVTATDR-- 425
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSLNLTEHY 1285
G P LSS++ + + + DV D + PVF Y + + EN A + V + +
Sbjct: 426 GKPPLSSSSSITLHIGDVND-----NAPVFSQSSYIVHVAENNPPGASISQVRASDPDLG 480
Query: 1286 ENFKMRYYILNEN--DTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
N ++ Y I+ + ++ I +G ++ R+ D E +E+ ++A Q
Sbjct: 481 PNGQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTLQARDQ 535
Score = 73.7 bits (173), Expect = 5e-12
Identities = 134/508 (26%), Positives = 203/508 (39%), Gaps = 75/508 (14%)
Query: 635 LSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENS- 692
L R + Y AL A LS V V D ND V + + + EN
Sbjct: 200 LDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYR---VSLSENVY 256
Query: 693 AGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVY 752
G + Q+ T+ + F + +T + G I LD E +V
Sbjct: 257 PGTTVLQVTATDQDE---GVNAEITFSFSEASQITQFDLNSNTGEITVLNTLDFE--EVK 311
Query: 753 RMTVIAEFNKGVISGAGIYQVTIYIE--DENDNPPVFEHATYEGFIMENSKIGTEIKMDN 810
+++ E G G I Q T+ +E DENDN P + IME++++GT I +
Sbjct: 312 EYSIVLEARDG---GGMIAQCTVEVEVIDENDNAPEVIFQSLPNLIMEDAELGTHIAL-- 366
Query: 811 IIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT 870
+K D D N GE K GD + +K+ +R+T
Sbjct: 367 -LKVRDKDSRHN--------GEV-----------TCKLEGD-------VPFKILTSSRNT 399
Query: 871 GGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALD 930
L ++A L + + PE+N I + R + L+ ++ T+ + N A
Sbjct: 400 YKLVTDAVL------DREQNPEYN-ITVTATDR--GKPPLSSSSSITL-HIGDVNDNAPV 449
Query: 931 VDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKR 990
Q + + EN P G +I ++ A D D G NGQ+ Y I S L + E+
Sbjct: 450 FSQSSYIVHVAENNPPGASISQVRASDPDLGPNGQVSY------CIMASDL--EQRELSS 501
Query: 991 YFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFP--V 1044
Y I+ G V R+ E F L + A D G+ L+ N+S+RV V D ND+ P +
Sbjct: 502 YVSISAESGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVDDRNDNAPRVL 561
Query: 1045 FKKTWYNFN-----VEEAQYTRRVLGKVDATDADFGQNANLTYFI-QPSDTDLPFEISPL 1098
+ + + V A ++ KV A DAD G NA L+Y + Q S+ L F +
Sbjct: 562 YPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGL-FSLGLR 620
Query: 1099 TGVLSVNGELDRETEDKYILTVVARDNG 1126
TG + L + L V RD G
Sbjct: 621 TGEVRTARALGDRDAVRQRLLVAVRDGG 648
Score = 73.7 bits (173), Expect = 5e-12
Identities = 74/270 (27%), Positives = 121/270 (44%), Gaps = 21/270 (7%)
Query: 889 NKPEFNQIEENSKVRIHRETKLNGTAGFTI-IEVKPKNKFALDVDQLGPLFLIPENIPIG 947
N +F +++E S V R+ A T+ +EV +N A +V LI E+ +G
Sbjct: 303 NTLDFEEVKEYSIVLEARDGG-GMIAQCTVEVEVIDENDNAPEVIFQSLPNLIMEDAELG 361
Query: 948 TTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSL 1007
T I L D DS NG++ + +V P K+ + Y ++ + ++ R
Sbjct: 362 THIALLKVRDKDSRHNGEVTCKLEGDV---PFKILTSSRNT--YKLVTD----AVLDREQ 412
Query: 1008 PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLG 1065
PE + + ++A D G L+ + S+ + + DVND+ PVF ++ Y +V E +
Sbjct: 413 NPE--YNITVTATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASIS 470
Query: 1066 KVDATDADFGQNANLTYFIQPSDTDLP-----FEISPLTGVLSVNGELDRETEDKYILTV 1120
+V A+D D G N ++Y I SD + IS +GV+ D E + LT+
Sbjct: 471 QVRASDPDLGPNGQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTL 530
Query: 1121 VARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
ARD G D NDN+P+
Sbjct: 531 QARDQG-SPALSANVSLRVLVDDRNDNAPR 559
Score = 65.3 bits (152), Expect = 2e-09
Identities = 122/491 (24%), Positives = 192/491 (39%), Gaps = 71/491 (14%)
Query: 938 FLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINER 997
+ IPE +P G+ + L A DL G + Q +P KL + K YF ++
Sbjct: 35 YRIPEEMPKGSVVGNL-ATDL--GFSVQ---------ELPTRKLRVSS--EKPYFTVSAE 80
Query: 998 HGHVIVARSLPPES------EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYN 1051
G ++V+ L E L A+ LN V V ++D+NDH P F + +
Sbjct: 81 SGELLVSSRLDREEICGKKPACALEFEAVAENPLNF-YHVNVEIEDINDHTPKFTQNSFE 139
Query: 1052 FNVEEAQY--TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGV----LSVN 1105
+ E+ TR +LG A DAD G N Y + PSD G + +
Sbjct: 140 LQISESAQPGTRFILGS--AHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYPEMVLK 197
Query: 1106 GELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEA 1165
LDRE + Y LT+ A D G D NDN+P
Sbjct: 198 TPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVT-DANDNAP---------------- 240
Query: 1166 DELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQ 1225
V VY+ ++ EN GTTV +V A D D N +S + Q
Sbjct: 241 ----------VFSQDVYRVSLSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQF 290
Query: 1226 NLGLPSLSSTAILMVTVADVPD---EVEMSDKPVFISR-YYELE-IEENVNAP-VELVSL 1279
+L + T + + +V + +E D I++ E+E I+EN NAP V SL
Sbjct: 291 DLNSNTGEITVLNTLDFEEVKEYSIVLEARDGGGMIAQCTVEVEVIDENDNAPEVIFQSL 350
Query: 1280 -NLTEHYENFKMRYYILNENDTDIRRTFVIDPR-NGTL-YLVRSPDREVKDTYEVIVRAE 1336
NL +L D D R + + G + + + + R +TY+++ A
Sbjct: 351 PNLIMEDAELGTHIALLKVRDKDSRHNGEVTCKLEGDVPFKILTSSR---NTYKLVTDAV 407
Query: 1337 RQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAP 1396
+ + + I A D + + + I DVNDN+P F+ + + + P
Sbjct: 408 LDR-EQNPEYNITVTATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSS--YIVHVAENNP 464
Query: 1397 FGYQVMQLKGA 1407
G + Q++ +
Sbjct: 465 PGASISQVRAS 475
Score = 57.2 bits (132), Expect = 4e-07
Identities = 32/98 (32%), Positives = 50/98 (51%), Gaps = 3/98 (3%)
Query: 246 LDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPE 305
L S + L + LD E N + N + V A+ P ++ + + + + D+NDN P
Sbjct: 393 LTSSRNTYKLVTDAVLDREQNPEYN---ITVTATDRGKPPLSSSSSITLHIGDVNDNAPV 449
Query: 306 FEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTY 343
F Y + + EN P G S+ QV A+D D G NG+ +Y
Sbjct: 450 FSQSSYIVHVAENNPPGASISQVRASDPDLGPNGQVSY 487
Score = 56.4 bits (130), Expect = 7e-07
Identities = 46/169 (27%), Positives = 74/169 (43%), Gaps = 9/169 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A DQD GV A + + + F L+S G + + LD + + + + ++
Sbjct: 264 VTATDQDEGVNAEITFSFSEASQITQFDLNSNTGEITVLNTLDFE-----EVKEYSIVLE 318
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A + AQ VE+E++D NDN PE I+E+ G + + DKD
Sbjct: 319 ARDGGGMI--AQCTVEVEVIDENDNAPEVIFQSLPNLIMEDAELGTHIALLKVRDKDSRH 376
Query: 338 NGEFTYQLD-DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
NGE T +L+ D R+ + V VLDRE + + V A +
Sbjct: 377 NGEVTCKLEGDVPFKILTSSRNTYKLV-TDAVLDREQNPEYNITVTATD 424
Score = 45.2 bits (102), Expect = 0.002
Identities = 42/150 (28%), Positives = 68/150 (45%), Gaps = 10/150 (6%)
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
+++ F++ + +G L + LD + E + L+ +A NPL VEIE D
Sbjct: 70 SEKPYFTVSAESGELLVSSRLDRE-EICGKKPACALEFEAVA-ENPLNFYHVNVEIE--D 125
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI---- 354
+ND+ P+F + + + I E+ G + A D D G N YQL P FS+
Sbjct: 126 INDHTPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQL-SPSDHFSLINKE 184
Query: 355 -DPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
S + + +T LDRE S + + A
Sbjct: 185 KSDGSKYPEMVLKTPLDREKQKSYHLTLTA 214
Score = 45.2 bits (102), Expect = 0.002
Identities = 48/172 (27%), Positives = 80/172 (46%), Gaps = 24/172 (13%)
Query: 218 IHAIDQDLGVGATLRYELISGN--DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTF 272
+ A D DLG + Y +++ + R+L S S++ G +F ++ D + Q F
Sbjct: 472 VRASDPDLGPNGQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHE-----QLRAF 526
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN---ISIVENLPN----GFSV 325
L +QA +P +A + + + D NDN P ++ + +P+ G+ V
Sbjct: 527 ELTLQARDQGSPALSANVSLRVLVDDRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLV 586
Query: 326 LQVMATDKDQGENGEFTY---QLDDPKGAFSIDPRSGWLTVRNQTVL-DREA 373
+V+A D D G N +Y Q +P G FS+ R+G VR L DR+A
Sbjct: 587 TKVVAVDADSGHNAWLSYHVLQASEP-GLFSLGLRTG--EVRTARALGDRDA 635
Score = 38.3 bits (85), Expect = 0.21
Identities = 18/41 (43%), Positives = 25/41 (60%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G +S+ S+T++I DVNDN P+F + Y V V E P G
Sbjct: 426 GKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPG 466
>BC112088-1|AAI12089.1| 803|Homo sapiens protocadherin gamma
subfamily B, 4, isoform 2 precursor protein.
Length = 803
Score = 110 bits (265), Expect = 3e-23
Identities = 120/471 (25%), Positives = 206/471 (43%), Gaps = 39/471 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E ++F +V V + D ND+ P F N +E + +A+ GT A D D+G N +
Sbjct: 111 ENPLNFYHVNVEIEDINDHTPKFT-QNSFELQISESAQPGTRFILGSAHDADIGSNTLQN 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLA 553
Y L + + ++ + K + + V ++P+ + + L + A D A P S A
Sbjct: 170 YQLSPSDHFSLINKEKSDGSKYPEMVLKTPLDREKQKSYHLTLTALDFGAPPLS---STA 226
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHG 613
+ + VT + P F Y + NV GT+V Q+ D + V+ ++
Sbjct: 227 QIHVLVTDAND----NAPVFSQDVYRVSLSENVYPGTTVLQVTATD--QDEGVNAEITFS 280
Query: 614 YEEG---VPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
+ E F + +G ITV++ L Y A ++ + V V+D N
Sbjct: 281 FSEASQITQFDLNSNTGEITVLNTLDFEEVKEYSIVLEA-RDGGGMIAQCTVEVEVIDEN 339
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
D ++ + +I +++ G I + + S + NG + + DV I
Sbjct: 340 DNAPEVIFQSLPNLI--MEDAELGTHIALLKVRDKDSRH-NGEVTCKL----EGDVPFKI 392
Query: 731 AIAEDGT--IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ T + T LDRE+ Y +TV A ++G + +T++I D NDN PVF
Sbjct: 393 LTSSRNTYKLVTDAVLDREQNPEYNITVTAT-DRGKPPLSSSSSITLHIGDVNDNAPVFS 451
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEM---FDVDEN 842
++Y + EN+ G I ++A+D D G N Y + E +E+ +
Sbjct: 452 QSSYIVHVAENNPPGASISQ---VRASDPDLGPNGQVSYCIMASDLEQRELSSYVSISAE 508
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
+GVV F + D E+ ++L+L ARD G LS+ L +++ D NDN P
Sbjct: 509 SGVV-FAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVDDRNDNAP 558
Score = 94.3 bits (224), Expect = 3e-18
Identities = 86/314 (27%), Positives = 141/314 (44%), Gaps = 23/314 (7%)
Query: 589 GTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN----RPMYD 644
G+ VG + + F ++ L E F V SG + V L R +P
Sbjct: 44 GSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVSAESGELLVSSRLDREEICGKKPACA 103
Query: 645 FEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTN 704
E A+ EN L+ + V + D+ND + + I + +G +
Sbjct: 104 LEFEAVAENP-LNFY-HVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILGSAHDAD 161
Query: 705 MSSIYGNG---TGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIA-EF 760
+ S + + F + N++ +D E + + PLDREK+ Y +T+ A +F
Sbjct: 162 IGSNTLQNYQLSPSDHFSLINKEK-SDGSKYPE---MVLKTPLDREKQKSYHLTLTALDF 217
Query: 761 NKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEG 820
+S Q+ + + D NDN PVF Y + EN GT + + ATD DEG
Sbjct: 218 GAPPLSSTA--QIHVLVTDANDNAPVFSQDVYRVSLSENVYPGTTVLQ---VTATDQDEG 272
Query: 821 TNALFMYTLFGEGKEM--FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAE 878
NA ++ F E ++ FD++ NTG + + ++LD E+ Y + L ARD GG+ ++
Sbjct: 273 VNAEITFS-FSEASQITQFDLNSNTGEITVL-NTLDFEEVKEYSIVLEARDGGGMIAQCT 330
Query: 879 LIIMIGDENDNKPE 892
+ + + DENDN PE
Sbjct: 331 VEVEVIDENDNAPE 344
Score = 77.4 bits (182), Expect = 4e-13
Identities = 45/148 (30%), Positives = 74/148 (50%), Gaps = 3/148 (2%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D+G Y+L + L + + +GS + E L + Q ++ L + A
Sbjct: 157 AHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYPEMVLKTPLDREKQ-KSYHLTLTAL 215
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
P ++ A++ + + D NDN P F D Y +S+ EN+ G +VLQV ATD+D+G N
Sbjct: 216 DFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVSLSENVYPGTTVLQVTATDQDEGVNA 275
Query: 340 EFTYQLDDPK--GAFSIDPRSGWLTVRN 365
E T+ + F ++ +G +TV N
Sbjct: 276 EITFSFSEASQITQFDLNSNTGEITVLN 303
Score = 75.8 bits (178), Expect = 1e-12
Identities = 56/169 (33%), Positives = 81/169 (47%), Gaps = 9/169 (5%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
AE G + LDRE+ + EF + Y V + IED ND+ P F ++
Sbjct: 79 AESGELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSF 138
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF---- 848
E I E+++ GT + + A DAD G+N L Y L E + K+
Sbjct: 139 ELQISESAQPGTRFILGS---AHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYPEMV 195
Query: 849 IGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+ LDREK+ Y L+L A D G LSS A++ +++ D NDN P F+Q
Sbjct: 196 LKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQ 244
Score = 75.8 bits (178), Expect = 1e-12
Identities = 98/415 (23%), Positives = 172/415 (41%), Gaps = 37/415 (8%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I E+ GT I +A D D G N Y+ + + S ++ + + +Y
Sbjct: 142 ISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHF--SLINKEKSDGSKY-------P 192
Query: 1000 HVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+++ L E + + L ++ALD G L+ + V V D ND+ PVF + Y ++
Sbjct: 193 EMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVSLS 252
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E Y + +V ATD D G NA +T+ + F+++ TG ++V LD E +
Sbjct: 253 ENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDLNSNTGEITVLNTLDFEEVKE 312
Query: 1116 YILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH---- 1171
Y + + ARD G D NDN+P+ F L +A EL H
Sbjct: 313 YSIVLEARDGG---GMIAQCTVEVEVIDENDNAPE-VIFQSLPNLIMEDA-ELGTHIALL 367
Query: 1172 --NFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL 1227
+ +E + P I T+ + TD + + Y++ +
Sbjct: 368 KVRDKDSRHNGEVTCKLEGDVPFKILTSSRNTYKLVTDAVLDREQNPEYNITVTATDR-- 425
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSLNLTEHY 1285
G P LSS++ + + + DV D + PVF Y + + EN A + V + +
Sbjct: 426 GKPPLSSSSSITLHIGDVND-----NAPVFSQSSYIVHVAENNPPGASISQVRASDPDLG 480
Query: 1286 ENFKMRYYILNEN--DTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
N ++ Y I+ + ++ I +G ++ R+ D E +E+ ++A Q
Sbjct: 481 PNGQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTLQARDQ 535
Score = 73.7 bits (173), Expect = 5e-12
Identities = 134/508 (26%), Positives = 203/508 (39%), Gaps = 75/508 (14%)
Query: 635 LSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENS- 692
L R + Y AL A LS V V D ND V + + + EN
Sbjct: 200 LDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYR---VSLSENVY 256
Query: 693 AGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVY 752
G + Q+ T+ + F + +T + G I LD E +V
Sbjct: 257 PGTTVLQVTATDQDE---GVNAEITFSFSEASQITQFDLNSNTGEITVLNTLDFE--EVK 311
Query: 753 RMTVIAEFNKGVISGAGIYQVTIYIE--DENDNPPVFEHATYEGFIMENSKIGTEIKMDN 810
+++ E G G I Q T+ +E DENDN P + IME++++GT I +
Sbjct: 312 EYSIVLEARDG---GGMIAQCTVEVEVIDENDNAPEVIFQSLPNLIMEDAELGTHIAL-- 366
Query: 811 IIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT 870
+K D D N GE K GD + +K+ +R+T
Sbjct: 367 -LKVRDKDSRHN--------GEV-----------TCKLEGD-------VPFKILTSSRNT 399
Query: 871 GGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALD 930
L ++A L + + PE+N I + R + L+ ++ T+ + N A
Sbjct: 400 YKLVTDAVL------DREQNPEYN-ITVTATDR--GKPPLSSSSSITL-HIGDVNDNAPV 449
Query: 931 VDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKR 990
Q + + EN P G +I ++ A D D G NGQ+ Y I S L + E+
Sbjct: 450 FSQSSYIVHVAENNPPGASISQVRASDPDLGPNGQVSY------CIMASDL--EQRELSS 501
Query: 991 YFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFP--V 1044
Y I+ G V R+ E F L + A D G+ L+ N+S+RV V D ND+ P +
Sbjct: 502 YVSISAESGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVDDRNDNAPRVL 561
Query: 1045 FKKTWYNFN-----VEEAQYTRRVLGKVDATDADFGQNANLTYFI-QPSDTDLPFEISPL 1098
+ + + V A ++ KV A DAD G NA L+Y + Q S+ L F +
Sbjct: 562 YPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGL-FSLGLR 620
Query: 1099 TGVLSVNGELDRETEDKYILTVVARDNG 1126
TG + L + L V RD G
Sbjct: 621 TGEVRTARALGDRDAVRQRLLVAVRDGG 648
Score = 73.7 bits (173), Expect = 5e-12
Identities = 74/270 (27%), Positives = 121/270 (44%), Gaps = 21/270 (7%)
Query: 889 NKPEFNQIEENSKVRIHRETKLNGTAGFTI-IEVKPKNKFALDVDQLGPLFLIPENIPIG 947
N +F +++E S V R+ A T+ +EV +N A +V LI E+ +G
Sbjct: 303 NTLDFEEVKEYSIVLEARDGG-GMIAQCTVEVEVIDENDNAPEVIFQSLPNLIMEDAELG 361
Query: 948 TTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSL 1007
T I L D DS NG++ + +V P K+ + Y ++ + ++ R
Sbjct: 362 THIALLKVRDKDSRHNGEVTCKLEGDV---PFKILTSSRNT--YKLVTD----AVLDREQ 412
Query: 1008 PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLG 1065
PE + + ++A D G L+ + S+ + + DVND+ PVF ++ Y +V E +
Sbjct: 413 NPE--YNITVTATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASIS 470
Query: 1066 KVDATDADFGQNANLTYFIQPSDTDLP-----FEISPLTGVLSVNGELDRETEDKYILTV 1120
+V A+D D G N ++Y I SD + IS +GV+ D E + LT+
Sbjct: 471 QVRASDPDLGPNGQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTL 530
Query: 1121 VARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
ARD G D NDN+P+
Sbjct: 531 QARDQG-SPALSANVSLRVLVDDRNDNAPR 559
Score = 65.3 bits (152), Expect = 2e-09
Identities = 122/491 (24%), Positives = 192/491 (39%), Gaps = 71/491 (14%)
Query: 938 FLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINER 997
+ IPE +P G+ + L A DL G + Q +P KL + K YF ++
Sbjct: 35 YRIPEEMPKGSVVGNL-ATDL--GFSVQ---------ELPTRKLRVSS--EKPYFTVSAE 80
Query: 998 HGHVIVARSLPPES------EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYN 1051
G ++V+ L E L A+ LN V V ++D+NDH P F + +
Sbjct: 81 SGELLVSSRLDREEICGKKPACALEFEAVAENPLNF-YHVNVEIEDINDHTPKFTQNSFE 139
Query: 1052 FNVEEAQY--TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGV----LSVN 1105
+ E+ TR +LG A DAD G N Y + PSD G + +
Sbjct: 140 LQISESAQPGTRFILGS--AHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYPEMVLK 197
Query: 1106 GELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEA 1165
LDRE + Y LT+ A D G D NDN+P
Sbjct: 198 TPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVT-DANDNAP---------------- 240
Query: 1166 DELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQ 1225
V VY+ ++ EN GTTV +V A D D N +S + Q
Sbjct: 241 ----------VFSQDVYRVSLSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQF 290
Query: 1226 NLGLPSLSSTAILMVTVADVPD---EVEMSDKPVFISR-YYELE-IEENVNAP-VELVSL 1279
+L + T + + +V + +E D I++ E+E I+EN NAP V SL
Sbjct: 291 DLNSNTGEITVLNTLDFEEVKEYSIVLEARDGGGMIAQCTVEVEVIDENDNAPEVIFQSL 350
Query: 1280 -NLTEHYENFKMRYYILNENDTDIRRTFVIDPR-NGTL-YLVRSPDREVKDTYEVIVRAE 1336
NL +L D D R + + G + + + + R +TY+++ A
Sbjct: 351 PNLIMEDAELGTHIALLKVRDKDSRHNGEVTCKLEGDVPFKILTSSR---NTYKLVTDAV 407
Query: 1337 RQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAP 1396
+ + + I A D + + + I DVNDN+P F+ + + + P
Sbjct: 408 LDR-EQNPEYNITVTATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSS--YIVHVAENNP 464
Query: 1397 FGYQVMQLKGA 1407
G + Q++ +
Sbjct: 465 PGASISQVRAS 475
Score = 57.2 bits (132), Expect = 4e-07
Identities = 32/98 (32%), Positives = 50/98 (51%), Gaps = 3/98 (3%)
Query: 246 LDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPE 305
L S + L + LD E N + N + V A+ P ++ + + + + D+NDN P
Sbjct: 393 LTSSRNTYKLVTDAVLDREQNPEYN---ITVTATDRGKPPLSSSSSITLHIGDVNDNAPV 449
Query: 306 FEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTY 343
F Y + + EN P G S+ QV A+D D G NG+ +Y
Sbjct: 450 FSQSSYIVHVAENNPPGASISQVRASDPDLGPNGQVSY 487
Score = 56.4 bits (130), Expect = 7e-07
Identities = 46/169 (27%), Positives = 74/169 (43%), Gaps = 9/169 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A DQD GV A + + + F L+S G + + LD + + + + ++
Sbjct: 264 VTATDQDEGVNAEITFSFSEASQITQFDLNSNTGEITVLNTLDFE-----EVKEYSIVLE 318
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A + AQ VE+E++D NDN PE I+E+ G + + DKD
Sbjct: 319 ARDGGGMI--AQCTVEVEVIDENDNAPEVIFQSLPNLIMEDAELGTHIALLKVRDKDSRH 376
Query: 338 NGEFTYQLD-DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
NGE T +L+ D R+ + V VLDRE + + V A +
Sbjct: 377 NGEVTCKLEGDVPFKILTSSRNTYKLV-TDAVLDREQNPEYNITVTATD 424
Score = 45.2 bits (102), Expect = 0.002
Identities = 42/150 (28%), Positives = 68/150 (45%), Gaps = 10/150 (6%)
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
+++ F++ + +G L + LD + E + L+ +A NPL VEIE D
Sbjct: 70 SEKPYFTVSAESGELLVSSRLDRE-EICGKKPACALEFEAVA-ENPLNFYHVNVEIE--D 125
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI---- 354
+ND+ P+F + + + I E+ G + A D D G N YQL P FS+
Sbjct: 126 INDHTPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQL-SPSDHFSLINKE 184
Query: 355 -DPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
S + + +T LDRE S + + A
Sbjct: 185 KSDGSKYPEMVLKTPLDREKQKSYHLTLTA 214
Score = 45.2 bits (102), Expect = 0.002
Identities = 48/172 (27%), Positives = 80/172 (46%), Gaps = 24/172 (13%)
Query: 218 IHAIDQDLGVGATLRYELISGN--DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTF 272
+ A D DLG + Y +++ + R+L S S++ G +F ++ D + Q F
Sbjct: 472 VRASDPDLGPNGQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHE-----QLRAF 526
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN---ISIVENLPN----GFSV 325
L +QA +P +A + + + D NDN P ++ + +P+ G+ V
Sbjct: 527 ELTLQARDQGSPALSANVSLRVLVDDRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLV 586
Query: 326 LQVMATDKDQGENGEFTY---QLDDPKGAFSIDPRSGWLTVRNQTVL-DREA 373
+V+A D D G N +Y Q +P G FS+ R+G VR L DR+A
Sbjct: 587 TKVVAVDADSGHNAWLSYHVLQASEP-GLFSLGLRTG--EVRTARALGDRDA 635
Score = 38.3 bits (85), Expect = 0.21
Identities = 18/41 (43%), Positives = 25/41 (60%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G +S+ S+T++I DVNDN P+F + Y V V E P G
Sbjct: 426 GKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPG 466
>BC033735-1|AAH33735.1| 890|Homo sapiens PCDHA5 protein protein.
Length = 890
Score = 110 bits (265), Expect = 3e-23
Identities = 121/425 (28%), Positives = 177/425 (41%), Gaps = 56/425 (13%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
++G +F +DRE+ R V ++ V + ++D NDNPP F
Sbjct: 79 QNGILFVNSRIDREELCRRRAECSIHLEVIVDRPLQVFHVEVAVKDINDNPPRFSRQEQR 138
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
FI+E+ + ++ A+D D G NA Y L E FD+D T
Sbjct: 139 LFILESRMPDSRFPLEG---ASDLDIGANAQLRYRL--NPNEYFDLDVKTN--------- 184
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
E++ + L LV R + E +++ + KPE L GT
Sbjct: 185 --EEETNF-LELVLRKSLDREETQEHRLLVIATDGGKPE-----------------LTGT 224
Query: 914 AGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
+I V N A + D+ + EN P GT +IKLNA D D G+N +I Y F
Sbjct: 225 VQL-LINVLDANDSAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFF--- 280
Query: 974 VYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN--LNDNI 1029
S L D +VK F+IN G + V L E + + +NI A+D L+ +
Sbjct: 281 -----SNLVLD--DVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHC 333
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
V V + DVND+ P T V+E V+ + +D D G N +T + P
Sbjct: 334 KVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMP--- 390
Query: 1090 DLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+PF+ +S S ++ LDRE+ Y L V ARD G DVND
Sbjct: 391 HVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGG-SPSLWATASVSVEVADVND 449
Query: 1147 NSPKF 1151
N+P F
Sbjct: 450 NAPAF 454
Score = 80.6 bits (190), Expect = 4e-14
Identities = 59/176 (33%), Positives = 89/176 (50%), Gaps = 18/176 (10%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLD---SVNGSLFLEKEL--DLDAEHNLQANTFVL 274
A D D+G A LRY L N + F LD + + FLE L LD E + V+
Sbjct: 156 ASDLDIGANAQLRYRL---NPNEYFDLDVKTNEEETNFLELVLRKSLDREETQEHRLLVI 212
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
A+ P T ++ I +LD ND+ PEF+ YN+ ++EN P+G V+++ A+D D
Sbjct: 213 ---ATDGGKPELTGTVQLLINVLDANDSAPEFDKSIYNVRLLENAPSGTLVIKLNASDAD 269
Query: 335 QGENGEFTY-----QLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+G N E Y LDD K F I+ +G + V + LD E ++S + + A +
Sbjct: 270 EGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGE--LDYEDYNSYEINIDAMD 323
Score = 79.0 bits (186), Expect = 1e-13
Identities = 106/452 (23%), Positives = 187/452 (41%), Gaps = 35/452 (7%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + + +LDAND+ P F S +Y + NA GT++ K+ A D D G N ++Y
Sbjct: 220 ELTGTVQLLINVLDANDSAPEFDKS-IYNVRLLENAPSGTLVIKLNASDADEGINKEIVY 278
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ S F IN NTG + V E + + ++A D+ P + V
Sbjct: 279 FFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVK 338
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
++V T P+ V + + T + I V+D + + +
Sbjct: 339 LLDVNDNT-------PEMAITTLFLPVKEDAPLSTVIALISVSD--RDSGANGQVTCSLM 389
Query: 616 EGVPF-AVEERSGVITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVND 671
VPF V ++V D L R + +Y+ A + +L + +V V DVND
Sbjct: 390 PHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVND 449
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLI----ANQQDVT 727
+ ++ +F VKEN+ IF + V + + ++ ++
Sbjct: 450 NAPAFAQPQYT--VF-VKENNPPGC--HIFTVSARDADAQENALVSYSLVERRVGERPLS 504
Query: 728 DDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
+++ AE G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 505 SYVSVHAESGKVYALQPLDHEEVELLQFQVSAR-DAGVPPLGSNVTLQVFVLDENDNAPA 563
Query: 787 FEHATYEGFIMENSK-IGTEIKMDNI---IKATDADEGTNALFMYTLF---GEGKEMFDV 839
G S+ + + ++ ++A D D G NA Y L G + F V
Sbjct: 564 LLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPFRV 623
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTG 871
TG + SLD + ++L ++ +D G
Sbjct: 624 GLYTGEIS-TTRSLDETEAPRHRLLVLVKDHG 654
Score = 74.9 bits (176), Expect = 2e-12
Identities = 117/479 (24%), Positives = 186/479 (38%), Gaps = 38/479 (7%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +VEV + D NDN P F F ++S + A D D+G
Sbjct: 104 HLEVIVDRPLQVFHVEVAVKDINDNPPRFSRQEQRLFILESRMP-DSRFPLEGASDLDIG 162
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPN-TGTVSVAESPILEGR----HALFVEASDQPANP 545
N + Y L + K N T + + L+ H L V A+D P
Sbjct: 163 ANAQLRYRLNPNEYFDLD--VKTNEEETNFLELVLRKSLDREETQEHRLLVIATDG-GKP 219
Query: 546 SERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--Q 603
T+++ P+F + Y + N GT V ++ +DA E
Sbjct: 220 E------LTGTVQLLINVLDANDSAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGIN 273
Query: 604 NDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVT 660
++ Y + + V F + +G I V +L + Y+ A+ ++ LS
Sbjct: 274 KEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHC 333
Query: 661 NATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLI 720
V ++DVND + A + + VKE++ + + I ++S G V +
Sbjct: 334 KVVVKLLDVNDNTPEM---AITTLFLPVKEDAPLSTV--IALISVSDRDSGANGQVTCSL 388
Query: 721 ANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDE 780
++ LDRE VY + V A + G S V++ + D
Sbjct: 389 MPHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTAR-DGGSPSLWATASVSVEVADV 447
Query: 781 NDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF----GEG--K 834
NDN P F Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 448 NDNAPAFAQPQYTVFVKENNPPGCHIFT---VSARDADAQENALVSYSLVERRVGERPLS 504
Query: 835 EMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 505 SYVSVHAESGKVYAL-QPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAP 562
Score = 61.3 bits (142), Expect = 3e-08
Identities = 77/343 (22%), Positives = 137/343 (39%), Gaps = 23/343 (6%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
++ G +++ + + + + D ND+ P F + Y+V + E P+G +
Sbjct: 211 VIATDGGKPELTGTVQLLINVLDANDSAPEFDKSIYNVRLLENAPSGTLVIKLNASDADE 270
Query: 127 SLTIPLTVPRGLTIFKDIRAFDRDKPNTP----NSDVHYSIVSGNDDGHFALESSHKPVL 182
+ + + D+++ NT N ++ Y + + A++ S P+
Sbjct: 271 GINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLS 330
Query: 183 LLRKVLD--YDAGDKEFQLVIMASGKRIHKEILFPEPIHAI---DQDLGVGATLRYELIS 237
KV+ D D ++ I + ++ I I D+D G + L+
Sbjct: 331 GHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMP 390
Query: 238 GNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELL 297
KL S SL L+ LD ++ + + L V A +P A A V +E+
Sbjct: 391 HVPFKLVSTFKNYYSLVLDSALDRES-----VSVYELVVTARDGGSPSLWATASVSVEVA 445
Query: 298 DLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL------DDPKGA 351
D+NDN P F Y + + EN P G + V A D D EN +Y L + P +
Sbjct: 446 DVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSS 505
Query: 352 F-SIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
+ S+ SG V LD E L+ +V A++ +G+
Sbjct: 506 YVSVHAESG--KVYALQPLDHEEVELLQFQVSARDAGVPPLGS 546
Score = 60.9 bits (141), Expect = 3e-08
Identities = 61/221 (27%), Positives = 92/221 (41%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y E +
Sbjct: 442 VEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL-VERRVGE 500
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVF 1034
LS+ Y ++ G V + L E + +SA D G L N++++VF
Sbjct: 501 RPLSS-------YVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVF 553
Query: 1035 VKDVNDHFPVFKKTWYNFN-------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
V D ND+ P V + V+ KV A D D G NA L+Y +QP+
Sbjct: 554 VLDENDNAPALLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPA 613
Query: 1088 --DTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+PF + TG +S LD ++ L V+ +D+G
Sbjct: 614 PGSARIPFRVGLYTGEISTTRSLDETEAPRHRLLVLVKDHG 654
Score = 60.1 bits (139), Expect = 6e-08
Identities = 44/188 (23%), Positives = 88/188 (46%), Gaps = 9/188 (4%)
Query: 218 IHAIDQDLGVGATLRY---ELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
++A D D G+ + Y L+ + + F ++S G + + ELD + N++ +
Sbjct: 263 LNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYE-----DYNSYEI 317
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + + +V ++LLD+NDN PE + + + E+ P + + +D+D
Sbjct: 318 NIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRD 377
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
G NG+ T L + + ++ + LDRE+ S + V A++ +PS+ T
Sbjct: 378 SGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWAT 437
Query: 394 FADSQRIA 401
+ S +A
Sbjct: 438 ASVSVEVA 445
Score = 55.2 bits (127), Expect = 2e-06
Identities = 69/227 (30%), Positives = 98/227 (43%), Gaps = 32/227 (14%)
Query: 937 LFL-IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVIN 995
LFL + E+ P+ T I ++ D DSG NGQ+ V P KL + K Y+ +
Sbjct: 354 LFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHV---PFKLVST---FKNYYSL- 406
Query: 996 ERHGHVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYN 1051
++ +L ES + L ++A DGG+ L SV V V DVND+ P F + Y
Sbjct: 407 ------VLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYT 460
Query: 1052 FNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGE---- 1107
V+E + V A DAD +NA ++Y S + PL+ +SV+ E
Sbjct: 461 VFVKENNPPGCHIFTVSARDADAQENALVSY----SLVERRVGERPLSSYVSVHAESGKV 516
Query: 1108 -----LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
LD E + V ARD G D NDN+P
Sbjct: 517 YALQPLDHEEVELLQFQVSARDAG-VPPLGSNVTLQVFVLDENDNAP 562
Score = 52.0 bits (119), Expect = 2e-05
Identities = 57/237 (24%), Positives = 94/237 (39%), Gaps = 14/237 (5%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
++V+D ND K ++ + EN+ + + N S + + +N
Sbjct: 229 INVLDANDSAPEFDKSIYN---VRLLENAPSGTL--VIKLNASDADEGINKEIVYFFSNL 283
Query: 724 --QDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDE 780
DV I + G I LD E + Y + + A +K +G +V + + D
Sbjct: 284 VLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDA-MDKSTFPLSGHCKVVVKLLDV 342
Query: 781 NDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVD 840
NDN P T + E++ + T I + I +D D G N +L
Sbjct: 343 NDNTPEMAITTLFLPVKEDAPLSTVIAL---ISVSDRDSGANGQVTCSLMPHVPFKLVST 399
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ 895
+ +LDRE +Y+L + ARD G L + A + + + D NDN P F Q
Sbjct: 400 FKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQ 456
Score = 45.6 bits (103), Expect = 0.001
Identities = 41/154 (26%), Positives = 71/154 (46%), Gaps = 24/154 (15%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++ V D D DK + Y + + EN + ++ LN ++ E
Sbjct: 217 GKPELTGTVQLLINVLDANDSAPEFDKSI-----YNVRLLENAPSGTLVIKLNASDADEG 271
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
N ++ Y+ N D++ F+I+ G + + D E ++YE+ + A +
Sbjct: 272 INKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDA--------MD 323
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPK 1379
+P L G KVVV++ DVNDN+P+
Sbjct: 324 KSTFP-----LSG----HCKVVVKLLDVNDNTPE 348
Score = 43.6 bits (98), Expect = 0.006
Identities = 80/331 (24%), Positives = 125/331 (37%), Gaps = 29/331 (8%)
Query: 77 ISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLT--- 133
+S + V V + DVNDN P T + V E P + ++ +T
Sbjct: 329 LSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSL 388
Query: 134 ---VPRGL-TIFKDIRAFDRDKPNTPNS-DVHYSIVSGNDDGHFALESSHKPVLLLRKVL 188
VP L + FK+ + D S V+ +V+ D G +L ++ + + V
Sbjct: 389 MPHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVN 448
Query: 189 DYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGN--DRKLFSL 246
D + Q + +F + A D D A + Y L+ +R L S
Sbjct: 449 DNAPAFAQPQYTVFVKENNPPGCHIFT--VSARDADAQENALVSYSLVERRVGERPLSSY 506
Query: 247 DSVN---GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNL 303
SV+ G ++ + LD + LQ QV A P + +++ +LD NDN
Sbjct: 507 VSVHAESGKVYALQPLDHEEVELLQ-----FQVSARDAGVPPLGSNVTLQVFVLDENDNA 561
Query: 304 PEF---EVDFYNISIVENLPN----GFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDP 356
P V ++ E +P G V +V A D D G N +Y+L G+ I
Sbjct: 562 PALLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPF 621
Query: 357 RSGWLTVRNQTV--LDREAHSSLRMKVYAKE 385
R G T T LD R+ V K+
Sbjct: 622 RVGLYTGEISTTRSLDETEAPRHRLLVLVKD 652
Score = 43.2 bits (97), Expect = 0.007
Identities = 52/185 (28%), Positives = 88/185 (47%), Gaps = 19/185 (10%)
Query: 221 IDQDLGVG-ATL---RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQ 275
I QDLG+ A L + + S L ++ NG LF+ +D + +A + L+
Sbjct: 47 IAQDLGLELAELVPRLFRVASKGRGDLLEVNLQNGILFVNSRIDREELCRRRAECSIHLE 106
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVEN-LPNGFSVLQVMATDKD 334
V ++ PL+ VE+ + D+NDN P F + I+E+ +P+ L+ A+D D
Sbjct: 107 VI---VDRPLQVFH--VEVAVKDINDNPPRFSRQEQRLFILESRMPDSRFPLE-GASDLD 160
Query: 335 QGENGEFTYQLDDPKGAFSIDPR-----SGWLTVRNQTVLDREAHSSLRMKVYAKE-TNP 388
G N + Y+L +P F +D + + +L + + LDRE R+ V A + P
Sbjct: 161 IGANAQLRYRL-NPNEYFDLDVKTNEEETNFLELVLRKSLDREETQEHRLLVIATDGGKP 219
Query: 389 SVVGT 393
+ GT
Sbjct: 220 ELTGT 224
>AF152520-1|AAD43780.1| 803|Homo sapiens protocadherin gamma B4
short form protein protein.
Length = 803
Score = 110 bits (265), Expect = 3e-23
Identities = 120/471 (25%), Positives = 206/471 (43%), Gaps = 39/471 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E ++F +V V + D ND+ P F N +E + +A+ GT A D D+G N +
Sbjct: 111 ENPLNFYHVNVEIEDINDHTPKFT-QNSFELQISESAQPGTRFILGSAHDADIGSNTLQN 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLA 553
Y L + + ++ + K + + V ++P+ + + L + A D A P S A
Sbjct: 170 YQLSPSDHFSLINKEKSDGSKYPEMVLKTPLDREKQKSYHLTLTALDFGAPPLS---STA 226
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHG 613
+ + VT + P F Y + NV GT+V Q+ D + V+ ++
Sbjct: 227 QIHVLVTDAND----NAPVFSQDVYRVSLSENVYPGTTVLQVTATD--QDEGVNAEITFS 280
Query: 614 YEEG---VPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
+ E F + +G ITV++ L Y A ++ + V V+D N
Sbjct: 281 FSEASQITQFDLNSNTGEITVLNTLDFEEVKEYSIVLEA-RDGGGMIAQCTVEVEVIDEN 339
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
D ++ + +I +++ G I + + S + NG + + DV I
Sbjct: 340 DNAPEVIFQSLPNLI--MEDAELGTHIALLKVRDKDSRH-NGEVTCKL----EGDVPFKI 392
Query: 731 AIAEDGT--IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ T + T LDRE+ Y +TV A ++G + +T++I D NDN PVF
Sbjct: 393 LTSSRNTYKLVTDAVLDREQNPEYNITVTAT-DRGKPPLSSSSSITLHIGDVNDNAPVFS 451
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEM---FDVDEN 842
++Y + EN+ G I ++A+D D G N Y + E +E+ +
Sbjct: 452 QSSYIVHVAENNPPGASISQ---VRASDPDLGPNGQVSYCIMASDLEQRELSSYVSISAE 508
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
+GVV F + D E+ ++L+L ARD G LS+ L +++ D NDN P
Sbjct: 509 SGVV-FAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVDDRNDNAP 558
Score = 94.3 bits (224), Expect = 3e-18
Identities = 86/314 (27%), Positives = 141/314 (44%), Gaps = 23/314 (7%)
Query: 589 GTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN----RPMYD 644
G+ VG + + F ++ L E F V SG + V L R +P
Sbjct: 44 GSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVSAESGELLVSSRLDREEICGKKPACA 103
Query: 645 FEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTN 704
E A+ EN L+ + V + D+ND + + I + +G +
Sbjct: 104 LEFEAVAENP-LNFY-HVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILGSAHDAD 161
Query: 705 MSSIYGNG---TGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIA-EF 760
+ S + + F + N++ +D E + + PLDREK+ Y +T+ A +F
Sbjct: 162 IGSNTLQNYQLSPSDHFSLINKEK-SDGSKYPE---MVLKTPLDREKQKSYHLTLTALDF 217
Query: 761 NKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEG 820
+S Q+ + + D NDN PVF Y + EN GT + + ATD DEG
Sbjct: 218 GAPPLSSTA--QIHVLVTDANDNAPVFSQDVYRVSLSENVYPGTTVLQ---VTATDQDEG 272
Query: 821 TNALFMYTLFGEGKEM--FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAE 878
NA ++ F E ++ FD++ NTG + + ++LD E+ Y + L ARD GG+ ++
Sbjct: 273 VNAEITFS-FSEASQITQFDLNSNTGEITVL-NTLDFEEVKEYSIVLEARDGGGMIAQCT 330
Query: 879 LIIMIGDENDNKPE 892
+ + + DENDN PE
Sbjct: 331 VEVEVIDENDNAPE 344
Score = 77.4 bits (182), Expect = 4e-13
Identities = 45/148 (30%), Positives = 74/148 (50%), Gaps = 3/148 (2%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D+G Y+L + L + + +GS + E L + Q ++ L + A
Sbjct: 157 AHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYPEMVLKTPLDREKQ-KSYHLTLTAL 215
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
P ++ A++ + + D NDN P F D Y +S+ EN+ G +VLQV ATD+D+G N
Sbjct: 216 DFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVSLSENVYPGTTVLQVTATDQDEGVNA 275
Query: 340 EFTYQLDDPK--GAFSIDPRSGWLTVRN 365
E T+ + F ++ +G +TV N
Sbjct: 276 EITFSFSEASQITQFDLNSNTGEITVLN 303
Score = 75.8 bits (178), Expect = 1e-12
Identities = 56/169 (33%), Positives = 81/169 (47%), Gaps = 9/169 (5%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
AE G + LDRE+ + EF + Y V + IED ND+ P F ++
Sbjct: 79 AESGELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSF 138
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF---- 848
E I E+++ GT + + A DAD G+N L Y L E + K+
Sbjct: 139 ELQISESAQPGTRFILGS---AHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYPEMV 195
Query: 849 IGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+ LDREK+ Y L+L A D G LSS A++ +++ D NDN P F+Q
Sbjct: 196 LKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQ 244
Score = 75.8 bits (178), Expect = 1e-12
Identities = 98/415 (23%), Positives = 172/415 (41%), Gaps = 37/415 (8%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I E+ GT I +A D D G N Y+ + + S ++ + + +Y
Sbjct: 142 ISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHF--SLINKEKSDGSKY-------P 192
Query: 1000 HVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+++ L E + + L ++ALD G L+ + V V D ND+ PVF + Y ++
Sbjct: 193 EMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVSLS 252
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E Y + +V ATD D G NA +T+ + F+++ TG ++V LD E +
Sbjct: 253 ENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDLNSNTGEITVLNTLDFEEVKE 312
Query: 1116 YILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH---- 1171
Y + + ARD G D NDN+P+ F L +A EL H
Sbjct: 313 YSIVLEARDGG---GMIAQCTVEVEVIDENDNAPE-VIFQSLPNLIMEDA-ELGTHIALL 367
Query: 1172 --NFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL 1227
+ +E + P I T+ + TD + + Y++ +
Sbjct: 368 KVRDKDSRHNGEVTCKLEGDVPFKILTSSRNTYKLVTDAVLDREQNPEYNITVTATDR-- 425
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSLNLTEHY 1285
G P LSS++ + + + DV D + PVF Y + + EN A + V + +
Sbjct: 426 GKPPLSSSSSITLHIGDVND-----NAPVFSQSSYIVHVAENNPPGASISQVRASDPDLG 480
Query: 1286 ENFKMRYYILNEN--DTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
N ++ Y I+ + ++ I +G ++ R+ D E +E+ ++A Q
Sbjct: 481 PNGQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTLQARDQ 535
Score = 73.7 bits (173), Expect = 5e-12
Identities = 134/508 (26%), Positives = 203/508 (39%), Gaps = 75/508 (14%)
Query: 635 LSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENS- 692
L R + Y AL A LS V V D ND V + + + EN
Sbjct: 200 LDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYR---VSLSENVY 256
Query: 693 AGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVY 752
G + Q+ T+ + F + +T + G I LD E +V
Sbjct: 257 PGTTVLQVTATDQDE---GVNAEITFSFSEASQITQFDLNSNTGEITVLNTLDFE--EVK 311
Query: 753 RMTVIAEFNKGVISGAGIYQVTIYIE--DENDNPPVFEHATYEGFIMENSKIGTEIKMDN 810
+++ E G G I Q T+ +E DENDN P + IME++++GT I +
Sbjct: 312 EYSIVLEARDG---GGMIAQCTVEVEVIDENDNAPEVIFQSLPNLIMEDAELGTHIAL-- 366
Query: 811 IIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT 870
+K D D N GE K GD + +K+ +R+T
Sbjct: 367 -LKVRDKDSRHN--------GEV-----------TCKLEGD-------VPFKILTSSRNT 399
Query: 871 GGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALD 930
L ++A L + + PE+N I + R + L+ ++ T+ + N A
Sbjct: 400 YKLVTDAVL------DREQNPEYN-ITVTATDR--GKPPLSSSSSITL-HIGDVNDNAPV 449
Query: 931 VDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKR 990
Q + + EN P G +I ++ A D D G NGQ+ Y I S L + E+
Sbjct: 450 FSQSSYIVHVAENNPPGASISQVRASDPDLGPNGQVSY------CIMASDL--EQRELSS 501
Query: 991 YFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFP--V 1044
Y I+ G V R+ E F L + A D G+ L+ N+S+RV V D ND+ P +
Sbjct: 502 YVSISAESGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVDDRNDNAPRVL 561
Query: 1045 FKKTWYNFN-----VEEAQYTRRVLGKVDATDADFGQNANLTYFI-QPSDTDLPFEISPL 1098
+ + + V A ++ KV A DAD G NA L+Y + Q S+ L F +
Sbjct: 562 YPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGL-FSLGLR 620
Query: 1099 TGVLSVNGELDRETEDKYILTVVARDNG 1126
TG + L + L V RD G
Sbjct: 621 TGEVRTARALGDRDAVRQRLLVAVRDGG 648
Score = 73.7 bits (173), Expect = 5e-12
Identities = 74/270 (27%), Positives = 121/270 (44%), Gaps = 21/270 (7%)
Query: 889 NKPEFNQIEENSKVRIHRETKLNGTAGFTI-IEVKPKNKFALDVDQLGPLFLIPENIPIG 947
N +F +++E S V R+ A T+ +EV +N A +V LI E+ +G
Sbjct: 303 NTLDFEEVKEYSIVLEARDGG-GMIAQCTVEVEVIDENDNAPEVIFQSLPNLIMEDAELG 361
Query: 948 TTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSL 1007
T I L D DS NG++ + +V P K+ + Y ++ + ++ R
Sbjct: 362 THIALLKVRDKDSRHNGEVTCKLEGDV---PFKILTSSRNT--YKLVTD----AVLDREQ 412
Query: 1008 PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLG 1065
PE + + ++A D G L+ + S+ + + DVND+ PVF ++ Y +V E +
Sbjct: 413 NPE--YNITVTATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASIS 470
Query: 1066 KVDATDADFGQNANLTYFIQPSDTDLP-----FEISPLTGVLSVNGELDRETEDKYILTV 1120
+V A+D D G N ++Y I SD + IS +GV+ D E + LT+
Sbjct: 471 QVRASDPDLGPNGQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTL 530
Query: 1121 VARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
ARD G D NDN+P+
Sbjct: 531 QARDQG-SPALSANVSLRVLVDDRNDNAPR 559
Score = 65.3 bits (152), Expect = 2e-09
Identities = 122/491 (24%), Positives = 192/491 (39%), Gaps = 71/491 (14%)
Query: 938 FLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINER 997
+ IPE +P G+ + L A DL G + Q +P KL + K YF ++
Sbjct: 35 YRIPEEMPKGSVVGNL-ATDL--GFSVQ---------ELPTRKLRVSS--EKPYFTVSAE 80
Query: 998 HGHVIVARSLPPES------EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYN 1051
G ++V+ L E L A+ LN V V ++D+NDH P F + +
Sbjct: 81 SGELLVSSRLDREEICGKKPACALEFEAVAENPLNF-YHVNVEIEDINDHTPKFTQNSFE 139
Query: 1052 FNVEEAQY--TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGV----LSVN 1105
+ E+ TR +LG A DAD G N Y + PSD G + +
Sbjct: 140 LQISESAQPGTRFILGS--AHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYPEMVLK 197
Query: 1106 GELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEA 1165
LDRE + Y LT+ A D G D NDN+P
Sbjct: 198 TPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVT-DANDNAP---------------- 240
Query: 1166 DELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQ 1225
V VY+ ++ EN GTTV +V A D D N +S + Q
Sbjct: 241 ----------VFSQDVYRVSLSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQF 290
Query: 1226 NLGLPSLSSTAILMVTVADVPD---EVEMSDKPVFISR-YYELE-IEENVNAP-VELVSL 1279
+L + T + + +V + +E D I++ E+E I+EN NAP V SL
Sbjct: 291 DLNSNTGEITVLNTLDFEEVKEYSIVLEARDGGGMIAQCTVEVEVIDENDNAPEVIFQSL 350
Query: 1280 -NLTEHYENFKMRYYILNENDTDIRRTFVIDPR-NGTL-YLVRSPDREVKDTYEVIVRAE 1336
NL +L D D R + + G + + + + R +TY+++ A
Sbjct: 351 PNLIMEDAELGTHIALLKVRDKDSRHNGEVTCKLEGDVPFKILTSSR---NTYKLVTDAV 407
Query: 1337 RQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAP 1396
+ + + I A D + + + I DVNDN+P F+ + + + P
Sbjct: 408 LDR-EQNPEYNITVTATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSS--YIVHVAENNP 464
Query: 1397 FGYQVMQLKGA 1407
G + Q++ +
Sbjct: 465 PGASISQVRAS 475
Score = 57.2 bits (132), Expect = 4e-07
Identities = 32/98 (32%), Positives = 50/98 (51%), Gaps = 3/98 (3%)
Query: 246 LDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPE 305
L S + L + LD E N + N + V A+ P ++ + + + + D+NDN P
Sbjct: 393 LTSSRNTYKLVTDAVLDREQNPEYN---ITVTATDRGKPPLSSSSSITLHIGDVNDNAPV 449
Query: 306 FEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTY 343
F Y + + EN P G S+ QV A+D D G NG+ +Y
Sbjct: 450 FSQSSYIVHVAENNPPGASISQVRASDPDLGPNGQVSY 487
Score = 56.4 bits (130), Expect = 7e-07
Identities = 46/169 (27%), Positives = 74/169 (43%), Gaps = 9/169 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A DQD GV A + + + F L+S G + + LD + + + + ++
Sbjct: 264 VTATDQDEGVNAEITFSFSEASQITQFDLNSNTGEITVLNTLDFE-----EVKEYSIVLE 318
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A + AQ VE+E++D NDN PE I+E+ G + + DKD
Sbjct: 319 ARDGGGMI--AQCTVEVEVIDENDNAPEVIFQSLPNLIMEDAELGTHIALLKVRDKDSRH 376
Query: 338 NGEFTYQLD-DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
NGE T +L+ D R+ + V VLDRE + + V A +
Sbjct: 377 NGEVTCKLEGDVPFKILTSSRNTYKLV-TDAVLDREQNPEYNITVTATD 424
Score = 45.2 bits (102), Expect = 0.002
Identities = 42/150 (28%), Positives = 68/150 (45%), Gaps = 10/150 (6%)
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
+++ F++ + +G L + LD + E + L+ +A NPL VEIE D
Sbjct: 70 SEKPYFTVSAESGELLVSSRLDRE-EICGKKPACALEFEAVA-ENPLNFYHVNVEIE--D 125
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI---- 354
+ND+ P+F + + + I E+ G + A D D G N YQL P FS+
Sbjct: 126 INDHTPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQL-SPSDHFSLINKE 184
Query: 355 -DPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
S + + +T LDRE S + + A
Sbjct: 185 KSDGSKYPEMVLKTPLDREKQKSYHLTLTA 214
Score = 45.2 bits (102), Expect = 0.002
Identities = 48/172 (27%), Positives = 80/172 (46%), Gaps = 24/172 (13%)
Query: 218 IHAIDQDLGVGATLRYELISGN--DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTF 272
+ A D DLG + Y +++ + R+L S S++ G +F ++ D + Q F
Sbjct: 472 VRASDPDLGPNGQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHE-----QLRAF 526
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN---ISIVENLPN----GFSV 325
L +QA +P +A + + + D NDN P ++ + +P+ G+ V
Sbjct: 527 ELTLQARDQGSPALSANVSLRVLVDDRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLV 586
Query: 326 LQVMATDKDQGENGEFTY---QLDDPKGAFSIDPRSGWLTVRNQTVL-DREA 373
+V+A D D G N +Y Q +P G FS+ R+G VR L DR+A
Sbjct: 587 TKVVAVDADSGHNAWLSYHVLQASEP-GLFSLGLRTG--EVRTARALGDRDA 635
Score = 38.3 bits (85), Expect = 0.21
Identities = 18/41 (43%), Positives = 25/41 (60%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G +S+ S+T++I DVNDN P+F + Y V V E P G
Sbjct: 426 GKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPG 466
>AF152333-1|AAD43727.1| 923|Homo sapiens protocadherin gamma B4
protein.
Length = 923
Score = 110 bits (265), Expect = 3e-23
Identities = 120/471 (25%), Positives = 206/471 (43%), Gaps = 39/471 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E ++F +V V + D ND+ P F N +E + +A+ GT A D D+G N +
Sbjct: 111 ENPLNFYHVNVEIEDINDHTPKFT-QNSFELQISESAQPGTRFILGSAHDADIGSNTLQN 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLA 553
Y L + + ++ + K + + V ++P+ + + L + A D A P S A
Sbjct: 170 YQLSPSDHFSLINKEKSDGSKYPEMVLKTPLDREKQKSYHLTLTALDFGAPPLS---STA 226
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHG 613
+ + VT + P F Y + NV GT+V Q+ D + V+ ++
Sbjct: 227 QIHVLVTDAND----NAPVFSQDVYRVSLSENVYPGTTVLQVTATD--QDEGVNAEITFS 280
Query: 614 YEEG---VPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
+ E F + +G ITV++ L Y A ++ + V V+D N
Sbjct: 281 FSEASQITQFDLNSNTGEITVLNTLDFEEVKEYSIVLEA-RDGGGMIAQCTVEVEVIDEN 339
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
D ++ + +I +++ G I + + S + NG + + DV I
Sbjct: 340 DNAPEVIFQSLPNLI--MEDAELGTHIALLKVRDKDSRH-NGEVTCKL----EGDVPFKI 392
Query: 731 AIAEDGT--IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ T + T LDRE+ Y +TV A ++G + +T++I D NDN PVF
Sbjct: 393 LTSSRNTYKLVTDAVLDREQNPEYNITVTAT-DRGKPPLSSSSSITLHIGDVNDNAPVFS 451
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEM---FDVDEN 842
++Y + EN+ G I ++A+D D G N Y + E +E+ +
Sbjct: 452 QSSYIVHVAENNPPGASISQ---VRASDPDLGPNGQVSYCIMASDLEQRELSSYVSISAE 508
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
+GVV F + D E+ ++L+L ARD G LS+ L +++ D NDN P
Sbjct: 509 SGVV-FAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVDDRNDNAP 558
Score = 94.3 bits (224), Expect = 3e-18
Identities = 86/314 (27%), Positives = 141/314 (44%), Gaps = 23/314 (7%)
Query: 589 GTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN----RPMYD 644
G+ VG + + F ++ L E F V SG + V L R +P
Sbjct: 44 GSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVSAESGELLVSSRLDREEICGKKPACA 103
Query: 645 FEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTN 704
E A+ EN L+ + V + D+ND + + I + +G +
Sbjct: 104 LEFEAVAENP-LNFY-HVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILGSAHDAD 161
Query: 705 MSSIYGNG---TGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIA-EF 760
+ S + + F + N++ +D E + + PLDREK+ Y +T+ A +F
Sbjct: 162 IGSNTLQNYQLSPSDHFSLINKEK-SDGSKYPE---MVLKTPLDREKQKSYHLTLTALDF 217
Query: 761 NKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEG 820
+S Q+ + + D NDN PVF Y + EN GT + + ATD DEG
Sbjct: 218 GAPPLSSTA--QIHVLVTDANDNAPVFSQDVYRVSLSENVYPGTTVLQ---VTATDQDEG 272
Query: 821 TNALFMYTLFGEGKEM--FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAE 878
NA ++ F E ++ FD++ NTG + + ++LD E+ Y + L ARD GG+ ++
Sbjct: 273 VNAEITFS-FSEASQITQFDLNSNTGEITVL-NTLDFEEVKEYSIVLEARDGGGMIAQCT 330
Query: 879 LIIMIGDENDNKPE 892
+ + + DENDN PE
Sbjct: 331 VEVEVIDENDNAPE 344
Score = 77.4 bits (182), Expect = 4e-13
Identities = 45/148 (30%), Positives = 74/148 (50%), Gaps = 3/148 (2%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D+G Y+L + L + + +GS + E L + Q ++ L + A
Sbjct: 157 AHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYPEMVLKTPLDREKQ-KSYHLTLTAL 215
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
P ++ A++ + + D NDN P F D Y +S+ EN+ G +VLQV ATD+D+G N
Sbjct: 216 DFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVSLSENVYPGTTVLQVTATDQDEGVNA 275
Query: 340 EFTYQLDDPK--GAFSIDPRSGWLTVRN 365
E T+ + F ++ +G +TV N
Sbjct: 276 EITFSFSEASQITQFDLNSNTGEITVLN 303
Score = 75.8 bits (178), Expect = 1e-12
Identities = 56/169 (33%), Positives = 81/169 (47%), Gaps = 9/169 (5%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
AE G + LDRE+ + EF + Y V + IED ND+ P F ++
Sbjct: 79 AESGELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSF 138
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF---- 848
E I E+++ GT + + A DAD G+N L Y L E + K+
Sbjct: 139 ELQISESAQPGTRFILGS---AHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYPEMV 195
Query: 849 IGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+ LDREK+ Y L+L A D G LSS A++ +++ D NDN P F+Q
Sbjct: 196 LKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQ 244
Score = 75.8 bits (178), Expect = 1e-12
Identities = 98/415 (23%), Positives = 172/415 (41%), Gaps = 37/415 (8%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I E+ GT I +A D D G N Y+ + + S ++ + + +Y
Sbjct: 142 ISESAQPGTRFILGSAHDADIGSNTLQNYQLSPSDHF--SLINKEKSDGSKY-------P 192
Query: 1000 HVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+++ L E + + L ++ALD G L+ + V V D ND+ PVF + Y ++
Sbjct: 193 EMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYRVSLS 252
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E Y + +V ATD D G NA +T+ + F+++ TG ++V LD E +
Sbjct: 253 ENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDLNSNTGEITVLNTLDFEEVKE 312
Query: 1116 YILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNH---- 1171
Y + + ARD G D NDN+P+ F L +A EL H
Sbjct: 313 YSIVLEARDGG---GMIAQCTVEVEVIDENDNAPE-VIFQSLPNLIMEDA-ELGTHIALL 367
Query: 1172 --NFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL 1227
+ +E + P I T+ + TD + + Y++ +
Sbjct: 368 KVRDKDSRHNGEVTCKLEGDVPFKILTSSRNTYKLVTDAVLDREQNPEYNITVTATDR-- 425
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSLNLTEHY 1285
G P LSS++ + + + DV D + PVF Y + + EN A + V + +
Sbjct: 426 GKPPLSSSSSITLHIGDVND-----NAPVFSQSSYIVHVAENNPPGASISQVRASDPDLG 480
Query: 1286 ENFKMRYYILNEN--DTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
N ++ Y I+ + ++ I +G ++ R+ D E +E+ ++A Q
Sbjct: 481 PNGQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTLQARDQ 535
Score = 73.7 bits (173), Expect = 5e-12
Identities = 134/508 (26%), Positives = 203/508 (39%), Gaps = 75/508 (14%)
Query: 635 LSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENS- 692
L R + Y AL A LS V V D ND V + + + EN
Sbjct: 200 LDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYR---VSLSENVY 256
Query: 693 AGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVY 752
G + Q+ T+ + F + +T + G I LD E +V
Sbjct: 257 PGTTVLQVTATDQDE---GVNAEITFSFSEASQITQFDLNSNTGEITVLNTLDFE--EVK 311
Query: 753 RMTVIAEFNKGVISGAGIYQVTIYIE--DENDNPPVFEHATYEGFIMENSKIGTEIKMDN 810
+++ E G G I Q T+ +E DENDN P + IME++++GT I +
Sbjct: 312 EYSIVLEARDG---GGMIAQCTVEVEVIDENDNAPEVIFQSLPNLIMEDAELGTHIAL-- 366
Query: 811 IIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDT 870
+K D D N GE K GD + +K+ +R+T
Sbjct: 367 -LKVRDKDSRHN--------GEV-----------TCKLEGD-------VPFKILTSSRNT 399
Query: 871 GGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALD 930
L ++A L + + PE+N I + R + L+ ++ T+ + N A
Sbjct: 400 YKLVTDAVL------DREQNPEYN-ITVTATDR--GKPPLSSSSSITL-HIGDVNDNAPV 449
Query: 931 VDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKR 990
Q + + EN P G +I ++ A D D G NGQ+ Y I S L + E+
Sbjct: 450 FSQSSYIVHVAENNPPGASISQVRASDPDLGPNGQVSY------CIMASDL--EQRELSS 501
Query: 991 YFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFP--V 1044
Y I+ G V R+ E F L + A D G+ L+ N+S+RV V D ND+ P +
Sbjct: 502 YVSISAESGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVDDRNDNAPRVL 561
Query: 1045 FKKTWYNFN-----VEEAQYTRRVLGKVDATDADFGQNANLTYFI-QPSDTDLPFEISPL 1098
+ + + V A ++ KV A DAD G NA L+Y + Q S+ L F +
Sbjct: 562 YPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGL-FSLGLR 620
Query: 1099 TGVLSVNGELDRETEDKYILTVVARDNG 1126
TG + L + L V RD G
Sbjct: 621 TGEVRTARALGDRDAVRQRLLVAVRDGG 648
Score = 73.7 bits (173), Expect = 5e-12
Identities = 74/270 (27%), Positives = 121/270 (44%), Gaps = 21/270 (7%)
Query: 889 NKPEFNQIEENSKVRIHRETKLNGTAGFTI-IEVKPKNKFALDVDQLGPLFLIPENIPIG 947
N +F +++E S V R+ A T+ +EV +N A +V LI E+ +G
Sbjct: 303 NTLDFEEVKEYSIVLEARDGG-GMIAQCTVEVEVIDENDNAPEVIFQSLPNLIMEDAELG 361
Query: 948 TTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSL 1007
T I L D DS NG++ + +V P K+ + Y ++ + ++ R
Sbjct: 362 THIALLKVRDKDSRHNGEVTCKLEGDV---PFKILTSSRNT--YKLVTD----AVLDREQ 412
Query: 1008 PPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLG 1065
PE + + ++A D G L+ + S+ + + DVND+ PVF ++ Y +V E +
Sbjct: 413 NPE--YNITVTATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASIS 470
Query: 1066 KVDATDADFGQNANLTYFIQPSDTDLP-----FEISPLTGVLSVNGELDRETEDKYILTV 1120
+V A+D D G N ++Y I SD + IS +GV+ D E + LT+
Sbjct: 471 QVRASDPDLGPNGQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHEQLRAFELTL 530
Query: 1121 VARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
ARD G D NDN+P+
Sbjct: 531 QARDQG-SPALSANVSLRVLVDDRNDNAPR 559
Score = 65.3 bits (152), Expect = 2e-09
Identities = 122/491 (24%), Positives = 192/491 (39%), Gaps = 71/491 (14%)
Query: 938 FLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINER 997
+ IPE +P G+ + L A DL G + Q +P KL + K YF ++
Sbjct: 35 YRIPEEMPKGSVVGNL-ATDL--GFSVQ---------ELPTRKLRVSS--EKPYFTVSAE 80
Query: 998 HGHVIVARSLPPES------EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYN 1051
G ++V+ L E L A+ LN V V ++D+NDH P F + +
Sbjct: 81 SGELLVSSRLDREEICGKKPACALEFEAVAENPLNF-YHVNVEIEDINDHTPKFTQNSFE 139
Query: 1052 FNVEEAQY--TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGV----LSVN 1105
+ E+ TR +LG A DAD G N Y + PSD G + +
Sbjct: 140 LQISESAQPGTRFILGS--AHDADIGSNTLQNYQLSPSDHFSLINKEKSDGSKYPEMVLK 197
Query: 1106 GELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEA 1165
LDRE + Y LT+ A D G D NDN+P
Sbjct: 198 TPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVT-DANDNAP---------------- 240
Query: 1166 DELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQ 1225
V VY+ ++ EN GTTV +V A D D N +S + Q
Sbjct: 241 ----------VFSQDVYRVSLSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQF 290
Query: 1226 NLGLPSLSSTAILMVTVADVPD---EVEMSDKPVFISR-YYELE-IEENVNAP-VELVSL 1279
+L + T + + +V + +E D I++ E+E I+EN NAP V SL
Sbjct: 291 DLNSNTGEITVLNTLDFEEVKEYSIVLEARDGGGMIAQCTVEVEVIDENDNAPEVIFQSL 350
Query: 1280 -NLTEHYENFKMRYYILNENDTDIRRTFVIDPR-NGTL-YLVRSPDREVKDTYEVIVRAE 1336
NL +L D D R + + G + + + + R +TY+++ A
Sbjct: 351 PNLIMEDAELGTHIALLKVRDKDSRHNGEVTCKLEGDVPFKILTSSR---NTYKLVTDAV 407
Query: 1337 RQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAP 1396
+ + + I A D + + + I DVNDN+P F+ + + + P
Sbjct: 408 LDR-EQNPEYNITVTATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSS--YIVHVAENNP 464
Query: 1397 FGYQVMQLKGA 1407
G + Q++ +
Sbjct: 465 PGASISQVRAS 475
Score = 57.2 bits (132), Expect = 4e-07
Identities = 32/98 (32%), Positives = 50/98 (51%), Gaps = 3/98 (3%)
Query: 246 LDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPE 305
L S + L + LD E N + N + V A+ P ++ + + + + D+NDN P
Sbjct: 393 LTSSRNTYKLVTDAVLDREQNPEYN---ITVTATDRGKPPLSSSSSITLHIGDVNDNAPV 449
Query: 306 FEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTY 343
F Y + + EN P G S+ QV A+D D G NG+ +Y
Sbjct: 450 FSQSSYIVHVAENNPPGASISQVRASDPDLGPNGQVSY 487
Score = 56.4 bits (130), Expect = 7e-07
Identities = 46/169 (27%), Positives = 74/169 (43%), Gaps = 9/169 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A DQD GV A + + + F L+S G + + LD + + + + ++
Sbjct: 264 VTATDQDEGVNAEITFSFSEASQITQFDLNSNTGEITVLNTLDFE-----EVKEYSIVLE 318
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A + AQ VE+E++D NDN PE I+E+ G + + DKD
Sbjct: 319 ARDGGGMI--AQCTVEVEVIDENDNAPEVIFQSLPNLIMEDAELGTHIALLKVRDKDSRH 376
Query: 338 NGEFTYQLD-DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
NGE T +L+ D R+ + V VLDRE + + V A +
Sbjct: 377 NGEVTCKLEGDVPFKILTSSRNTYKLV-TDAVLDREQNPEYNITVTATD 424
Score = 45.2 bits (102), Expect = 0.002
Identities = 42/150 (28%), Positives = 68/150 (45%), Gaps = 10/150 (6%)
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
+++ F++ + +G L + LD + E + L+ +A NPL VEIE D
Sbjct: 70 SEKPYFTVSAESGELLVSSRLDRE-EICGKKPACALEFEAVA-ENPLNFYHVNVEIE--D 125
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI---- 354
+ND+ P+F + + + I E+ G + A D D G N YQL P FS+
Sbjct: 126 INDHTPKFTQNSFELQISESAQPGTRFILGSAHDADIGSNTLQNYQL-SPSDHFSLINKE 184
Query: 355 -DPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
S + + +T LDRE S + + A
Sbjct: 185 KSDGSKYPEMVLKTPLDREKQKSYHLTLTA 214
Score = 45.2 bits (102), Expect = 0.002
Identities = 48/172 (27%), Positives = 80/172 (46%), Gaps = 24/172 (13%)
Query: 218 IHAIDQDLGVGATLRYELISGN--DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTF 272
+ A D DLG + Y +++ + R+L S S++ G +F ++ D + Q F
Sbjct: 472 VRASDPDLGPNGQVSYCIMASDLEQRELSSYVSISAESGVVFAQRAFDHE-----QLRAF 526
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN---ISIVENLPN----GFSV 325
L +QA +P +A + + + D NDN P ++ + +P+ G+ V
Sbjct: 527 ELTLQARDQGSPALSANVSLRVLVDDRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLV 586
Query: 326 LQVMATDKDQGENGEFTY---QLDDPKGAFSIDPRSGWLTVRNQTVL-DREA 373
+V+A D D G N +Y Q +P G FS+ R+G VR L DR+A
Sbjct: 587 TKVVAVDADSGHNAWLSYHVLQASEP-GLFSLGLRTG--EVRTARALGDRDA 635
Score = 38.3 bits (85), Expect = 0.21
Identities = 18/41 (43%), Positives = 25/41 (60%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G +S+ S+T++I DVNDN P+F + Y V V E P G
Sbjct: 426 GKPPLSSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPG 466
>AF152483-1|AAD43744.1| 816|Homo sapiens protocadherin alpha 5 short
form protein protein.
Length = 816
Score = 110 bits (264), Expect = 4e-23
Identities = 121/425 (28%), Positives = 177/425 (41%), Gaps = 56/425 (13%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
++G +F +DRE+ R V ++ V + ++D NDNPP F
Sbjct: 79 QNGILFVNSRIDREELCRRRAECSIHLEVIVDRPLQVFHVEVAVKDINDNPPRFSRQEQR 138
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
FI+E+ + ++ A+D D G NA Y L E FD+D T
Sbjct: 139 LFILESRMPDSRFPLEG---ASDLDIGANAQLRYRL--NPNEYFDLDVKTN--------- 184
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
E++ + L LV R + E +++ + KPE L GT
Sbjct: 185 --EEETNF-LELVLRKSLDREETQEHRLLVIATDGGKPE-----------------LTGT 224
Query: 914 AGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
+I V N A + D+ + EN P GT +IKLNA D D G+N +I Y F
Sbjct: 225 VQL-LINVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFF--- 280
Query: 974 VYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN--LNDNI 1029
S L D +VK F+IN G + V L E + + +NI A+D L+ +
Sbjct: 281 -----SNLVLD--DVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHC 333
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
V V + DVND+ P T V+E V+ + +D D G N +T + P
Sbjct: 334 KVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMP--- 390
Query: 1090 DLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+PF+ +S S ++ LDRE+ Y L V ARD G DVND
Sbjct: 391 HVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGG-SPSLWATASVSVEVADVND 449
Query: 1147 NSPKF 1151
N+P F
Sbjct: 450 NAPAF 454
Score = 82.6 bits (195), Expect = 1e-14
Identities = 60/176 (34%), Positives = 89/176 (50%), Gaps = 18/176 (10%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLD---SVNGSLFLEKEL--DLDAEHNLQANTFVL 274
A D D+G A LRY L N + F LD + + FLE L LD E + V+
Sbjct: 156 ASDLDIGANAQLRYRL---NPNEYFDLDVKTNEEETNFLELVLRKSLDREETQEHRLLVI 212
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
A+ P T ++ I +LD NDN PEF+ YN+ ++EN P+G V+++ A+D D
Sbjct: 213 ---ATDGGKPELTGTVQLLINVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDAD 269
Query: 335 QGENGEFTY-----QLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+G N E Y LDD K F I+ +G + V + LD E ++S + + A +
Sbjct: 270 EGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGE--LDYEDYNSYEINIDAMD 323
Score = 81.0 bits (191), Expect = 3e-14
Identities = 107/452 (23%), Positives = 187/452 (41%), Gaps = 35/452 (7%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + + +LDANDN P F S +Y + NA GT++ K+ A D D G N ++Y
Sbjct: 220 ELTGTVQLLINVLDANDNAPEFDKS-IYNVRLLENAPSGTLVIKLNASDADEGINKEIVY 278
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ S F IN NTG + V E + + ++A D+ P + V
Sbjct: 279 FFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVK 338
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
++V T P+ V + + T + I V+D + + +
Sbjct: 339 LLDVNDNT-------PEMAITTLFLPVKEDAPLSTVIALISVSD--RDSGANGQVTCSLM 389
Query: 616 EGVPF-AVEERSGVITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVND 671
VPF V ++V D L R + +Y+ A + +L + +V V DVND
Sbjct: 390 PHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVND 449
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLI----ANQQDVT 727
+ ++ +F VKEN+ IF + V + + ++ ++
Sbjct: 450 NAPAFAQPQYT--VF-VKENNPPGC--HIFTVSARDADAQENALVSYSLVERRVGERPLS 504
Query: 728 DDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
+++ AE G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 505 SYVSVHAESGKVYALQPLDHEEVELLQFQVSAR-DAGVPPLGSNVTLQVFVLDENDNAPA 563
Query: 787 FEHATYEGFIMENSK-IGTEIKMDNI---IKATDADEGTNALFMYTLF---GEGKEMFDV 839
G S+ + + ++ ++A D D G NA Y L G + F V
Sbjct: 564 LLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPFRV 623
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTG 871
TG + SLD + ++L ++ +D G
Sbjct: 624 GLYTGEIS-TTRSLDETEAPRHRLLVLVKDHG 654
Score = 75.4 bits (177), Expect = 1e-12
Identities = 117/479 (24%), Positives = 187/479 (39%), Gaps = 38/479 (7%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +VEV + D NDN P F F ++S + A D D+G
Sbjct: 104 HLEVIVDRPLQVFHVEVAVKDINDNPPRFSRQEQRLFILESRMP-DSRFPLEGASDLDIG 162
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPN-TGTVSVAESPILEGR----HALFVEASDQPANP 545
N + Y L + K N T + + L+ H L V A+D P
Sbjct: 163 ANAQLRYRLNPNEYFDLD--VKTNEEETNFLELVLRKSLDREETQEHRLLVIATDG-GKP 219
Query: 546 SERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--Q 603
T+++ + P+F + Y + N GT V ++ +DA E
Sbjct: 220 E------LTGTVQLLINVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGIN 273
Query: 604 NDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVT 660
++ Y + + V F + +G I V +L + Y+ A+ ++ LS
Sbjct: 274 KEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHC 333
Query: 661 NATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLI 720
V ++DVND + A + + VKE++ + + I ++S G V +
Sbjct: 334 KVVVKLLDVNDNTPEM---AITTLFLPVKEDAPLSTV--IALISVSDRDSGANGQVTCSL 388
Query: 721 ANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDE 780
++ LDRE VY + V A + G S V++ + D
Sbjct: 389 MPHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTAR-DGGSPSLWATASVSVEVADV 447
Query: 781 NDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF----GEG--K 834
NDN P F Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 448 NDNAPAFAQPQYTVFVKENNPPGCHIFT---VSARDADAQENALVSYSLVERRVGERPLS 504
Query: 835 EMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 505 SYVSVHAESGKVYAL-QPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAP 562
Score = 63.3 bits (147), Expect = 6e-09
Identities = 78/343 (22%), Positives = 137/343 (39%), Gaps = 23/343 (6%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
++ G +++ + + + + D NDN P F + Y+V + E P+G +
Sbjct: 211 VIATDGGKPELTGTVQLLINVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDADE 270
Query: 127 SLTIPLTVPRGLTIFKDIRAFDRDKPNTP----NSDVHYSIVSGNDDGHFALESSHKPVL 182
+ + + D+++ NT N ++ Y + + A++ S P+
Sbjct: 271 GINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLS 330
Query: 183 LLRKVLD--YDAGDKEFQLVIMASGKRIHKEILFPEPIHAI---DQDLGVGATLRYELIS 237
KV+ D D ++ I + ++ I I D+D G + L+
Sbjct: 331 GHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMP 390
Query: 238 GNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELL 297
KL S SL L+ LD ++ + + L V A +P A A V +E+
Sbjct: 391 HVPFKLVSTFKNYYSLVLDSALDRES-----VSVYELVVTARDGGSPSLWATASVSVEVA 445
Query: 298 DLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL------DDPKGA 351
D+NDN P F Y + + EN P G + V A D D EN +Y L + P +
Sbjct: 446 DVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSS 505
Query: 352 F-SIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
+ S+ SG V LD E L+ +V A++ +G+
Sbjct: 506 YVSVHAESG--KVYALQPLDHEEVELLQFQVSARDAGVPPLGS 546
Score = 60.9 bits (141), Expect = 3e-08
Identities = 61/221 (27%), Positives = 92/221 (41%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y E +
Sbjct: 442 VEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL-VERRVGE 500
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVF 1034
LS+ Y ++ G V + L E + +SA D G L N++++VF
Sbjct: 501 RPLSS-------YVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVF 553
Query: 1035 VKDVNDHFPVFKKTWYNFN-------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
V D ND+ P V + V+ KV A D D G NA L+Y +QP+
Sbjct: 554 VLDENDNAPALLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPA 613
Query: 1088 --DTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+PF + TG +S LD ++ L V+ +D+G
Sbjct: 614 PGSARIPFRVGLYTGEISTTRSLDETEAPRHRLLVLVKDHG 654
Score = 60.1 bits (139), Expect = 6e-08
Identities = 44/188 (23%), Positives = 88/188 (46%), Gaps = 9/188 (4%)
Query: 218 IHAIDQDLGVGATLRY---ELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
++A D D G+ + Y L+ + + F ++S G + + ELD + N++ +
Sbjct: 263 LNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYE-----DYNSYEI 317
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + + +V ++LLD+NDN PE + + + E+ P + + +D+D
Sbjct: 318 NIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRD 377
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
G NG+ T L + + ++ + LDRE+ S + V A++ +PS+ T
Sbjct: 378 SGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWAT 437
Query: 394 FADSQRIA 401
+ S +A
Sbjct: 438 ASVSVEVA 445
Score = 55.2 bits (127), Expect = 2e-06
Identities = 69/227 (30%), Positives = 98/227 (43%), Gaps = 32/227 (14%)
Query: 937 LFL-IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVIN 995
LFL + E+ P+ T I ++ D DSG NGQ+ V P KL + K Y+ +
Sbjct: 354 LFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHV---PFKLVST---FKNYYSL- 406
Query: 996 ERHGHVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYN 1051
++ +L ES + L ++A DGG+ L SV V V DVND+ P F + Y
Sbjct: 407 ------VLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYT 460
Query: 1052 FNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGE---- 1107
V+E + V A DAD +NA ++Y S + PL+ +SV+ E
Sbjct: 461 VFVKENNPPGCHIFTVSARDADAQENALVSY----SLVERRVGERPLSSYVSVHAESGKV 516
Query: 1108 -----LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
LD E + V ARD G D NDN+P
Sbjct: 517 YALQPLDHEEVELLQFQVSARDAG-VPPLGSNVTLQVFVLDENDNAP 562
Score = 52.0 bits (119), Expect = 2e-05
Identities = 57/237 (24%), Positives = 94/237 (39%), Gaps = 14/237 (5%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
++V+D ND K ++ + EN+ + + N S + + +N
Sbjct: 229 INVLDANDNAPEFDKSIYN---VRLLENAPSGTL--VIKLNASDADEGINKEIVYFFSNL 283
Query: 724 --QDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDE 780
DV I + G I LD E + Y + + A +K +G +V + + D
Sbjct: 284 VLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDA-MDKSTFPLSGHCKVVVKLLDV 342
Query: 781 NDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVD 840
NDN P T + E++ + T I + I +D D G N +L
Sbjct: 343 NDNTPEMAITTLFLPVKEDAPLSTVIAL---ISVSDRDSGANGQVTCSLMPHVPFKLVST 399
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ 895
+ +LDRE +Y+L + ARD G L + A + + + D NDN P F Q
Sbjct: 400 FKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQ 456
Score = 45.6 bits (103), Expect = 0.001
Identities = 41/154 (26%), Positives = 71/154 (46%), Gaps = 24/154 (15%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++ V D D DK + Y + + EN + ++ LN ++ E
Sbjct: 217 GKPELTGTVQLLINVLDANDNAPEFDKSI-----YNVRLLENAPSGTLVIKLNASDADEG 271
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
N ++ Y+ N D++ F+I+ G + + D E ++YE+ + A +
Sbjct: 272 INKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDA--------MD 323
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPK 1379
+P L G KVVV++ DVNDN+P+
Sbjct: 324 KSTFP-----LSG----HCKVVVKLLDVNDNTPE 348
Score = 43.6 bits (98), Expect = 0.006
Identities = 80/331 (24%), Positives = 125/331 (37%), Gaps = 29/331 (8%)
Query: 77 ISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLT--- 133
+S + V V + DVNDN P T + V E P + ++ +T
Sbjct: 329 LSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSL 388
Query: 134 ---VPRGL-TIFKDIRAFDRDKPNTPNS-DVHYSIVSGNDDGHFALESSHKPVLLLRKVL 188
VP L + FK+ + D S V+ +V+ D G +L ++ + + V
Sbjct: 389 MPHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVN 448
Query: 189 DYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGN--DRKLFSL 246
D + Q + +F + A D D A + Y L+ +R L S
Sbjct: 449 DNAPAFAQPQYTVFVKENNPPGCHIFT--VSARDADAQENALVSYSLVERRVGERPLSSY 506
Query: 247 DSVN---GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNL 303
SV+ G ++ + LD + LQ QV A P + +++ +LD NDN
Sbjct: 507 VSVHAESGKVYALQPLDHEEVELLQ-----FQVSARDAGVPPLGSNVTLQVFVLDENDNA 561
Query: 304 PEF---EVDFYNISIVENLPN----GFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDP 356
P V ++ E +P G V +V A D D G N +Y+L G+ I
Sbjct: 562 PALLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPF 621
Query: 357 RSGWLTVRNQTV--LDREAHSSLRMKVYAKE 385
R G T T LD R+ V K+
Sbjct: 622 RVGLYTGEISTTRSLDETEAPRHRLLVLVKD 652
Score = 43.2 bits (97), Expect = 0.007
Identities = 52/185 (28%), Positives = 88/185 (47%), Gaps = 19/185 (10%)
Query: 221 IDQDLGVG-ATL---RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQ 275
I QDLG+ A L + + S L ++ NG LF+ +D + +A + L+
Sbjct: 47 IAQDLGLELAELVPRLFRVASKGRGDLLEVNLQNGILFVNSRIDREELCRRRAECSIHLE 106
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVEN-LPNGFSVLQVMATDKD 334
V ++ PL+ VE+ + D+NDN P F + I+E+ +P+ L+ A+D D
Sbjct: 107 VI---VDRPLQVFH--VEVAVKDINDNPPRFSRQEQRLFILESRMPDSRFPLE-GASDLD 160
Query: 335 QGENGEFTYQLDDPKGAFSIDPR-----SGWLTVRNQTVLDREAHSSLRMKVYAKE-TNP 388
G N + Y+L +P F +D + + +L + + LDRE R+ V A + P
Sbjct: 161 IGANAQLRYRL-NPNEYFDLDVKTNEEETNFLELVLRKSLDREETQEHRLLVIATDGGKP 219
Query: 389 SVVGT 393
+ GT
Sbjct: 220 ELTGT 224
>AF152313-1|AAD43707.1| 936|Homo sapiens protocadherin alpha 5
protein.
Length = 936
Score = 110 bits (264), Expect = 4e-23
Identities = 121/425 (28%), Positives = 177/425 (41%), Gaps = 56/425 (13%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
++G +F +DRE+ R V ++ V + ++D NDNPP F
Sbjct: 79 QNGILFVNSRIDREELCRRRAECSIHLEVIVDRPLQVFHVEVAVKDINDNPPRFSRQEQR 138
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
FI+E+ + ++ A+D D G NA Y L E FD+D T
Sbjct: 139 LFILESRMPDSRFPLEG---ASDLDIGANAQLRYRL--NPNEYFDLDVKTN--------- 184
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
E++ + L LV R + E +++ + KPE L GT
Sbjct: 185 --EEETNF-LELVLRKSLDREETQEHRLLVIATDGGKPE-----------------LTGT 224
Query: 914 AGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
+I V N A + D+ + EN P GT +IKLNA D D G+N +I Y F
Sbjct: 225 VQL-LINVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFF--- 280
Query: 974 VYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN--LNDNI 1029
S L D +VK F+IN G + V L E + + +NI A+D L+ +
Sbjct: 281 -----SNLVLD--DVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHC 333
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
V V + DVND+ P T V+E V+ + +D D G N +T + P
Sbjct: 334 KVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMP--- 390
Query: 1090 DLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+PF+ +S S ++ LDRE+ Y L V ARD G DVND
Sbjct: 391 HVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGG-SPSLWATASVSVEVADVND 449
Query: 1147 NSPKF 1151
N+P F
Sbjct: 450 NAPAF 454
Score = 82.6 bits (195), Expect = 1e-14
Identities = 60/176 (34%), Positives = 89/176 (50%), Gaps = 18/176 (10%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLD---SVNGSLFLEKEL--DLDAEHNLQANTFVL 274
A D D+G A LRY L N + F LD + + FLE L LD E + V+
Sbjct: 156 ASDLDIGANAQLRYRL---NPNEYFDLDVKTNEEETNFLELVLRKSLDREETQEHRLLVI 212
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
A+ P T ++ I +LD NDN PEF+ YN+ ++EN P+G V+++ A+D D
Sbjct: 213 ---ATDGGKPELTGTVQLLINVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDAD 269
Query: 335 QGENGEFTY-----QLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+G N E Y LDD K F I+ +G + V + LD E ++S + + A +
Sbjct: 270 EGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGE--LDYEDYNSYEINIDAMD 323
Score = 81.0 bits (191), Expect = 3e-14
Identities = 107/452 (23%), Positives = 187/452 (41%), Gaps = 35/452 (7%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + + +LDANDN P F S +Y + NA GT++ K+ A D D G N ++Y
Sbjct: 220 ELTGTVQLLINVLDANDNAPEFDKS-IYNVRLLENAPSGTLVIKLNASDADEGINKEIVY 278
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ S F IN NTG + V E + + ++A D+ P + V
Sbjct: 279 FFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVK 338
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
++V T P+ V + + T + I V+D + + +
Sbjct: 339 LLDVNDNT-------PEMAITTLFLPVKEDAPLSTVIALISVSD--RDSGANGQVTCSLM 389
Query: 616 EGVPF-AVEERSGVITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVND 671
VPF V ++V D L R + +Y+ A + +L + +V V DVND
Sbjct: 390 PHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVND 449
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLI----ANQQDVT 727
+ ++ +F VKEN+ IF + V + + ++ ++
Sbjct: 450 NAPAFAQPQYT--VF-VKENNPPGC--HIFTVSARDADAQENALVSYSLVERRVGERPLS 504
Query: 728 DDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
+++ AE G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 505 SYVSVHAESGKVYALQPLDHEEVELLQFQVSAR-DAGVPPLGSNVTLQVFVLDENDNAPA 563
Query: 787 FEHATYEGFIMENSK-IGTEIKMDNI---IKATDADEGTNALFMYTLF---GEGKEMFDV 839
G S+ + + ++ ++A D D G NA Y L G + F V
Sbjct: 564 LLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPFRV 623
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTG 871
TG + SLD + ++L ++ +D G
Sbjct: 624 GLYTGEIS-TTRSLDETEAPRHRLLVLVKDHG 654
Score = 75.4 bits (177), Expect = 1e-12
Identities = 117/479 (24%), Positives = 187/479 (39%), Gaps = 38/479 (7%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +VEV + D NDN P F F ++S + A D D+G
Sbjct: 104 HLEVIVDRPLQVFHVEVAVKDINDNPPRFSRQEQRLFILESRMP-DSRFPLEGASDLDIG 162
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPN-TGTVSVAESPILEGR----HALFVEASDQPANP 545
N + Y L + K N T + + L+ H L V A+D P
Sbjct: 163 ANAQLRYRLNPNEYFDLD--VKTNEEETNFLELVLRKSLDREETQEHRLLVIATDG-GKP 219
Query: 546 SERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--Q 603
T+++ + P+F + Y + N GT V ++ +DA E
Sbjct: 220 E------LTGTVQLLINVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGIN 273
Query: 604 NDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVT 660
++ Y + + V F + +G I V +L + Y+ A+ ++ LS
Sbjct: 274 KEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHC 333
Query: 661 NATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLI 720
V ++DVND + A + + VKE++ + + I ++S G V +
Sbjct: 334 KVVVKLLDVNDNTPEM---AITTLFLPVKEDAPLSTV--IALISVSDRDSGANGQVTCSL 388
Query: 721 ANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDE 780
++ LDRE VY + V A + G S V++ + D
Sbjct: 389 MPHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTAR-DGGSPSLWATASVSVEVADV 447
Query: 781 NDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF----GEG--K 834
NDN P F Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 448 NDNAPAFAQPQYTVFVKENNPPGCHIFT---VSARDADAQENALVSYSLVERRVGERPLS 504
Query: 835 EMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 505 SYVSVHAESGKVYAL-QPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAP 562
Score = 63.3 bits (147), Expect = 6e-09
Identities = 78/343 (22%), Positives = 137/343 (39%), Gaps = 23/343 (6%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
++ G +++ + + + + D NDN P F + Y+V + E P+G +
Sbjct: 211 VIATDGGKPELTGTVQLLINVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDADE 270
Query: 127 SLTIPLTVPRGLTIFKDIRAFDRDKPNTP----NSDVHYSIVSGNDDGHFALESSHKPVL 182
+ + + D+++ NT N ++ Y + + A++ S P+
Sbjct: 271 GINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLS 330
Query: 183 LLRKVLD--YDAGDKEFQLVIMASGKRIHKEILFPEPIHAI---DQDLGVGATLRYELIS 237
KV+ D D ++ I + ++ I I D+D G + L+
Sbjct: 331 GHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMP 390
Query: 238 GNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELL 297
KL S SL L+ LD ++ + + L V A +P A A V +E+
Sbjct: 391 HVPFKLVSTFKNYYSLVLDSALDRES-----VSVYELVVTARDGGSPSLWATASVSVEVA 445
Query: 298 DLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL------DDPKGA 351
D+NDN P F Y + + EN P G + V A D D EN +Y L + P +
Sbjct: 446 DVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSS 505
Query: 352 F-SIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
+ S+ SG V LD E L+ +V A++ +G+
Sbjct: 506 YVSVHAESG--KVYALQPLDHEEVELLQFQVSARDAGVPPLGS 546
Score = 60.9 bits (141), Expect = 3e-08
Identities = 61/221 (27%), Positives = 92/221 (41%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y E +
Sbjct: 442 VEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL-VERRVGE 500
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVF 1034
LS+ Y ++ G V + L E + +SA D G L N++++VF
Sbjct: 501 RPLSS-------YVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVF 553
Query: 1035 VKDVNDHFPVFKKTWYNFN-------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
V D ND+ P V + V+ KV A D D G NA L+Y +QP+
Sbjct: 554 VLDENDNAPALLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPA 613
Query: 1088 --DTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+PF + TG +S LD ++ L V+ +D+G
Sbjct: 614 PGSARIPFRVGLYTGEISTTRSLDETEAPRHRLLVLVKDHG 654
Score = 60.1 bits (139), Expect = 6e-08
Identities = 44/188 (23%), Positives = 88/188 (46%), Gaps = 9/188 (4%)
Query: 218 IHAIDQDLGVGATLRY---ELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
++A D D G+ + Y L+ + + F ++S G + + ELD + N++ +
Sbjct: 263 LNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYE-----DYNSYEI 317
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + + +V ++LLD+NDN PE + + + E+ P + + +D+D
Sbjct: 318 NIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRD 377
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
G NG+ T L + + ++ + LDRE+ S + V A++ +PS+ T
Sbjct: 378 SGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWAT 437
Query: 394 FADSQRIA 401
+ S +A
Sbjct: 438 ASVSVEVA 445
Score = 55.2 bits (127), Expect = 2e-06
Identities = 69/227 (30%), Positives = 98/227 (43%), Gaps = 32/227 (14%)
Query: 937 LFL-IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVIN 995
LFL + E+ P+ T I ++ D DSG NGQ+ V P KL + K Y+ +
Sbjct: 354 LFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHV---PFKLVST---FKNYYSL- 406
Query: 996 ERHGHVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYN 1051
++ +L ES + L ++A DGG+ L SV V V DVND+ P F + Y
Sbjct: 407 ------VLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYT 460
Query: 1052 FNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGE---- 1107
V+E + V A DAD +NA ++Y S + PL+ +SV+ E
Sbjct: 461 VFVKENNPPGCHIFTVSARDADAQENALVSY----SLVERRVGERPLSSYVSVHAESGKV 516
Query: 1108 -----LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
LD E + V ARD G D NDN+P
Sbjct: 517 YALQPLDHEEVELLQFQVSARDAG-VPPLGSNVTLQVFVLDENDNAP 562
Score = 52.0 bits (119), Expect = 2e-05
Identities = 57/237 (24%), Positives = 94/237 (39%), Gaps = 14/237 (5%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
++V+D ND K ++ + EN+ + + N S + + +N
Sbjct: 229 INVLDANDNAPEFDKSIYN---VRLLENAPSGTL--VIKLNASDADEGINKEIVYFFSNL 283
Query: 724 --QDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDE 780
DV I + G I LD E + Y + + A +K +G +V + + D
Sbjct: 284 VLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDA-MDKSTFPLSGHCKVVVKLLDV 342
Query: 781 NDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVD 840
NDN P T + E++ + T I + I +D D G N +L
Sbjct: 343 NDNTPEMAITTLFLPVKEDAPLSTVIAL---ISVSDRDSGANGQVTCSLMPHVPFKLVST 399
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ 895
+ +LDRE +Y+L + ARD G L + A + + + D NDN P F Q
Sbjct: 400 FKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQ 456
Score = 45.6 bits (103), Expect = 0.001
Identities = 41/154 (26%), Positives = 71/154 (46%), Gaps = 24/154 (15%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++ V D D DK + Y + + EN + ++ LN ++ E
Sbjct: 217 GKPELTGTVQLLINVLDANDNAPEFDKSI-----YNVRLLENAPSGTLVIKLNASDADEG 271
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
N ++ Y+ N D++ F+I+ G + + D E ++YE+ + A +
Sbjct: 272 INKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDA--------MD 323
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPK 1379
+P L G KVVV++ DVNDN+P+
Sbjct: 324 KSTFP-----LSG----HCKVVVKLLDVNDNTPE 348
Score = 43.6 bits (98), Expect = 0.006
Identities = 80/331 (24%), Positives = 125/331 (37%), Gaps = 29/331 (8%)
Query: 77 ISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLT--- 133
+S + V V + DVNDN P T + V E P + ++ +T
Sbjct: 329 LSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSL 388
Query: 134 ---VPRGL-TIFKDIRAFDRDKPNTPNS-DVHYSIVSGNDDGHFALESSHKPVLLLRKVL 188
VP L + FK+ + D S V+ +V+ D G +L ++ + + V
Sbjct: 389 MPHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVN 448
Query: 189 DYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGN--DRKLFSL 246
D + Q + +F + A D D A + Y L+ +R L S
Sbjct: 449 DNAPAFAQPQYTVFVKENNPPGCHIFT--VSARDADAQENALVSYSLVERRVGERPLSSY 506
Query: 247 DSVN---GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNL 303
SV+ G ++ + LD + LQ QV A P + +++ +LD NDN
Sbjct: 507 VSVHAESGKVYALQPLDHEEVELLQ-----FQVSARDAGVPPLGSNVTLQVFVLDENDNA 561
Query: 304 PEF---EVDFYNISIVENLPN----GFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDP 356
P V ++ E +P G V +V A D D G N +Y+L G+ I
Sbjct: 562 PALLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPF 621
Query: 357 RSGWLTVRNQTV--LDREAHSSLRMKVYAKE 385
R G T T LD R+ V K+
Sbjct: 622 RVGLYTGEISTTRSLDETEAPRHRLLVLVKD 652
Score = 43.2 bits (97), Expect = 0.007
Identities = 52/185 (28%), Positives = 88/185 (47%), Gaps = 19/185 (10%)
Query: 221 IDQDLGVG-ATL---RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQ 275
I QDLG+ A L + + S L ++ NG LF+ +D + +A + L+
Sbjct: 47 IAQDLGLELAELVPRLFRVASKGRGDLLEVNLQNGILFVNSRIDREELCRRRAECSIHLE 106
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVEN-LPNGFSVLQVMATDKD 334
V ++ PL+ VE+ + D+NDN P F + I+E+ +P+ L+ A+D D
Sbjct: 107 VI---VDRPLQVFH--VEVAVKDINDNPPRFSRQEQRLFILESRMPDSRFPLE-GASDLD 160
Query: 335 QGENGEFTYQLDDPKGAFSIDPR-----SGWLTVRNQTVLDREAHSSLRMKVYAKE-TNP 388
G N + Y+L +P F +D + + +L + + LDRE R+ V A + P
Sbjct: 161 IGANAQLRYRL-NPNEYFDLDVKTNEEETNFLELVLRKSLDREETQEHRLLVIATDGGKP 219
Query: 389 SVVGT 393
+ GT
Sbjct: 220 ELTGT 224
>AC005609-9|AAC34321.1| 816|Homo sapiens KIAA0345-like 9 protein.
Length = 816
Score = 110 bits (264), Expect = 4e-23
Identities = 121/425 (28%), Positives = 177/425 (41%), Gaps = 56/425 (13%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
++G +F +DRE+ R V ++ V + ++D NDNPP F
Sbjct: 79 QNGILFVNSRIDREELCRRRAECSIHLEVIVDRPLQVFHVEVAVKDINDNPPRFSRQEQR 138
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
FI+E+ + ++ A+D D G NA Y L E FD+D T
Sbjct: 139 LFILESRMPDSRFPLEG---ASDLDIGANAQLRYRL--NPNEYFDLDVKTN--------- 184
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
E++ + L LV R + E +++ + KPE L GT
Sbjct: 185 --EEETNF-LELVLRKSLDREETQEHRLLVIATDGGKPE-----------------LTGT 224
Query: 914 AGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
+I V N A + D+ + EN P GT +IKLNA D D G+N +I Y F
Sbjct: 225 VQL-LINVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFF--- 280
Query: 974 VYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN--LNDNI 1029
S L D +VK F+IN G + V L E + + +NI A+D L+ +
Sbjct: 281 -----SNLVLD--DVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHC 333
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
V V + DVND+ P T V+E V+ + +D D G N +T + P
Sbjct: 334 KVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMP--- 390
Query: 1090 DLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+PF+ +S S ++ LDRE+ Y L V ARD G DVND
Sbjct: 391 HVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGG-SPSLWATASVSVEVADVND 449
Query: 1147 NSPKF 1151
N+P F
Sbjct: 450 NAPAF 454
Score = 82.6 bits (195), Expect = 1e-14
Identities = 60/176 (34%), Positives = 89/176 (50%), Gaps = 18/176 (10%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLD---SVNGSLFLEKEL--DLDAEHNLQANTFVL 274
A D D+G A LRY L N + F LD + + FLE L LD E + V+
Sbjct: 156 ASDLDIGANAQLRYRL---NPNEYFDLDVKTNEEETNFLELVLRKSLDREETQEHRLLVI 212
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
A+ P T ++ I +LD NDN PEF+ YN+ ++EN P+G V+++ A+D D
Sbjct: 213 ---ATDGGKPELTGTVQLLINVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDAD 269
Query: 335 QGENGEFTY-----QLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+G N E Y LDD K F I+ +G + V + LD E ++S + + A +
Sbjct: 270 EGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGE--LDYEDYNSYEINIDAMD 323
Score = 81.0 bits (191), Expect = 3e-14
Identities = 107/452 (23%), Positives = 187/452 (41%), Gaps = 35/452 (7%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + + +LDANDN P F S +Y + NA GT++ K+ A D D G N ++Y
Sbjct: 220 ELTGTVQLLINVLDANDNAPEFDKS-IYNVRLLENAPSGTLVIKLNASDADEGINKEIVY 278
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ S F IN NTG + V E + + ++A D+ P + V
Sbjct: 279 FFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVK 338
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
++V T P+ V + + T + I V+D + + +
Sbjct: 339 LLDVNDNT-------PEMAITTLFLPVKEDAPLSTVIALISVSD--RDSGANGQVTCSLM 389
Query: 616 EGVPF-AVEERSGVITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVND 671
VPF V ++V D L R + +Y+ A + +L + +V V DVND
Sbjct: 390 PHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVND 449
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLI----ANQQDVT 727
+ ++ +F VKEN+ IF + V + + ++ ++
Sbjct: 450 NAPAFAQPQYT--VF-VKENNPPGC--HIFTVSARDADAQENALVSYSLVERRVGERPLS 504
Query: 728 DDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
+++ AE G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 505 SYVSVHAESGKVYALQPLDHEEVELLQFQVSAR-DAGVPPLGSNVTLQVFVLDENDNAPA 563
Query: 787 FEHATYEGFIMENSK-IGTEIKMDNI---IKATDADEGTNALFMYTLF---GEGKEMFDV 839
G S+ + + ++ ++A D D G NA Y L G + F V
Sbjct: 564 LLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPFRV 623
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTG 871
TG + SLD + ++L ++ +D G
Sbjct: 624 GLYTGEIS-TTRSLDETEAPRHRLLVLVKDHG 654
Score = 75.4 bits (177), Expect = 1e-12
Identities = 117/479 (24%), Positives = 187/479 (39%), Gaps = 38/479 (7%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +VEV + D NDN P F F ++S + A D D+G
Sbjct: 104 HLEVIVDRPLQVFHVEVAVKDINDNPPRFSRQEQRLFILESRMP-DSRFPLEGASDLDIG 162
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPN-TGTVSVAESPILEGR----HALFVEASDQPANP 545
N + Y L + K N T + + L+ H L V A+D P
Sbjct: 163 ANAQLRYRLNPNEYFDLD--VKTNEEETNFLELVLRKSLDREETQEHRLLVIATDG-GKP 219
Query: 546 SERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--Q 603
T+++ + P+F + Y + N GT V ++ +DA E
Sbjct: 220 E------LTGTVQLLINVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGIN 273
Query: 604 NDVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVT 660
++ Y + + V F + +G I V +L + Y+ A+ ++ LS
Sbjct: 274 KEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHC 333
Query: 661 NATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLI 720
V ++DVND + A + + VKE++ + + I ++S G V +
Sbjct: 334 KVVVKLLDVNDNTPEM---AITTLFLPVKEDAPLSTV--IALISVSDRDSGANGQVTCSL 388
Query: 721 ANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDE 780
++ LDRE VY + V A + G S V++ + D
Sbjct: 389 MPHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTAR-DGGSPSLWATASVSVEVADV 447
Query: 781 NDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF----GEG--K 834
NDN P F Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 448 NDNAPAFAQPQYTVFVKENNPPGCHIFT---VSARDADAQENALVSYSLVERRVGERPLS 504
Query: 835 EMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 505 SYVSVHAESGKVYAL-QPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAP 562
Score = 63.3 bits (147), Expect = 6e-09
Identities = 78/343 (22%), Positives = 137/343 (39%), Gaps = 23/343 (6%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
++ G +++ + + + + D NDN P F + Y+V + E P+G +
Sbjct: 211 VIATDGGKPELTGTVQLLINVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDADE 270
Query: 127 SLTIPLTVPRGLTIFKDIRAFDRDKPNTP----NSDVHYSIVSGNDDGHFALESSHKPVL 182
+ + + D+++ NT N ++ Y + + A++ S P+
Sbjct: 271 GINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLS 330
Query: 183 LLRKVLD--YDAGDKEFQLVIMASGKRIHKEILFPEPIHAI---DQDLGVGATLRYELIS 237
KV+ D D ++ I + ++ I I D+D G + L+
Sbjct: 331 GHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMP 390
Query: 238 GNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELL 297
KL S SL L+ LD ++ + + L V A +P A A V +E+
Sbjct: 391 HVPFKLVSTFKNYYSLVLDSALDRES-----VSVYELVVTARDGGSPSLWATASVSVEVA 445
Query: 298 DLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL------DDPKGA 351
D+NDN P F Y + + EN P G + V A D D EN +Y L + P +
Sbjct: 446 DVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSS 505
Query: 352 F-SIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
+ S+ SG V LD E L+ +V A++ +G+
Sbjct: 506 YVSVHAESG--KVYALQPLDHEEVELLQFQVSARDAGVPPLGS 546
Score = 60.9 bits (141), Expect = 3e-08
Identities = 61/221 (27%), Positives = 92/221 (41%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y E +
Sbjct: 442 VEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL-VERRVGE 500
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVF 1034
LS+ Y ++ G V + L E + +SA D G L N++++VF
Sbjct: 501 RPLSS-------YVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVF 553
Query: 1035 VKDVNDHFPVFKKTWYNFN-------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
V D ND+ P V + V+ KV A D D G NA L+Y +QP+
Sbjct: 554 VLDENDNAPALLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPA 613
Query: 1088 --DTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+PF + TG +S LD ++ L V+ +D+G
Sbjct: 614 PGSARIPFRVGLYTGEISTTRSLDETEAPRHRLLVLVKDHG 654
Score = 60.1 bits (139), Expect = 6e-08
Identities = 44/188 (23%), Positives = 88/188 (46%), Gaps = 9/188 (4%)
Query: 218 IHAIDQDLGVGATLRY---ELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
++A D D G+ + Y L+ + + F ++S G + + ELD + N++ +
Sbjct: 263 LNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYE-----DYNSYEI 317
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A + + +V ++LLD+NDN PE + + + E+ P + + +D+D
Sbjct: 318 NIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRD 377
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
G NG+ T L + + ++ + LDRE+ S + V A++ +PS+ T
Sbjct: 378 SGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWAT 437
Query: 394 FADSQRIA 401
+ S +A
Sbjct: 438 ASVSVEVA 445
Score = 55.2 bits (127), Expect = 2e-06
Identities = 69/227 (30%), Positives = 98/227 (43%), Gaps = 32/227 (14%)
Query: 937 LFL-IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVIN 995
LFL + E+ P+ T I ++ D DSG NGQ+ V P KL + K Y+ +
Sbjct: 354 LFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHV---PFKLVST---FKNYYSL- 406
Query: 996 ERHGHVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYN 1051
++ +L ES + L ++A DGG+ L SV V V DVND+ P F + Y
Sbjct: 407 ------VLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYT 460
Query: 1052 FNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGE---- 1107
V+E + V A DAD +NA ++Y S + PL+ +SV+ E
Sbjct: 461 VFVKENNPPGCHIFTVSARDADAQENALVSY----SLVERRVGERPLSSYVSVHAESGKV 516
Query: 1108 -----LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
LD E + V ARD G D NDN+P
Sbjct: 517 YALQPLDHEEVELLQFQVSARDAG-VPPLGSNVTLQVFVLDENDNAP 562
Score = 52.0 bits (119), Expect = 2e-05
Identities = 57/237 (24%), Positives = 94/237 (39%), Gaps = 14/237 (5%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
++V+D ND K ++ + EN+ + + N S + + +N
Sbjct: 229 INVLDANDNAPEFDKSIYN---VRLLENAPSGTL--VIKLNASDADEGINKEIVYFFSNL 283
Query: 724 --QDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDE 780
DV I + G I LD E + Y + + A +K +G +V + + D
Sbjct: 284 VLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDA-MDKSTFPLSGHCKVVVKLLDV 342
Query: 781 NDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVD 840
NDN P T + E++ + T I + I +D D G N +L
Sbjct: 343 NDNTPEMAITTLFLPVKEDAPLSTVIAL---ISVSDRDSGANGQVTCSLMPHVPFKLVST 399
Query: 841 ENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ 895
+ +LDRE +Y+L + ARD G L + A + + + D NDN P F Q
Sbjct: 400 FKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQ 456
Score = 45.6 bits (103), Expect = 0.001
Identities = 41/154 (26%), Positives = 71/154 (46%), Gaps = 24/154 (15%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++ V D D DK + Y + + EN + ++ LN ++ E
Sbjct: 217 GKPELTGTVQLLINVLDANDNAPEFDKSI-----YNVRLLENAPSGTLVIKLNASDADEG 271
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
N ++ Y+ N D++ F+I+ G + + D E ++YE+ + A +
Sbjct: 272 INKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDA--------MD 323
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPK 1379
+P L G KVVV++ DVNDN+P+
Sbjct: 324 KSTFP-----LSG----HCKVVVKLLDVNDNTPE 348
Score = 43.6 bits (98), Expect = 0.006
Identities = 80/331 (24%), Positives = 125/331 (37%), Gaps = 29/331 (8%)
Query: 77 ISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLT--- 133
+S + V V + DVNDN P T + V E P + ++ +T
Sbjct: 329 LSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSL 388
Query: 134 ---VPRGL-TIFKDIRAFDRDKPNTPNS-DVHYSIVSGNDDGHFALESSHKPVLLLRKVL 188
VP L + FK+ + D S V+ +V+ D G +L ++ + + V
Sbjct: 389 MPHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVN 448
Query: 189 DYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGN--DRKLFSL 246
D + Q + +F + A D D A + Y L+ +R L S
Sbjct: 449 DNAPAFAQPQYTVFVKENNPPGCHIFT--VSARDADAQENALVSYSLVERRVGERPLSSY 506
Query: 247 DSVN---GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNL 303
SV+ G ++ + LD + LQ QV A P + +++ +LD NDN
Sbjct: 507 VSVHAESGKVYALQPLDHEEVELLQ-----FQVSARDAGVPPLGSNVTLQVFVLDENDNA 561
Query: 304 PEF---EVDFYNISIVENLPN----GFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDP 356
P V ++ E +P G V +V A D D G N +Y+L G+ I
Sbjct: 562 PALLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPF 621
Query: 357 RSGWLTVRNQTV--LDREAHSSLRMKVYAKE 385
R G T T LD R+ V K+
Sbjct: 622 RVGLYTGEISTTRSLDETEAPRHRLLVLVKD 652
Score = 43.2 bits (97), Expect = 0.007
Identities = 52/185 (28%), Positives = 88/185 (47%), Gaps = 19/185 (10%)
Query: 221 IDQDLGVG-ATL---RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQ 275
I QDLG+ A L + + S L ++ NG LF+ +D + +A + L+
Sbjct: 47 IAQDLGLELAELVPRLFRVASKGRGDLLEVNLQNGILFVNSRIDREELCRRRAECSIHLE 106
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVEN-LPNGFSVLQVMATDKD 334
V ++ PL+ VE+ + D+NDN P F + I+E+ +P+ L+ A+D D
Sbjct: 107 VI---VDRPLQVFH--VEVAVKDINDNPPRFSRQEQRLFILESRMPDSRFPLE-GASDLD 160
Query: 335 QGENGEFTYQLDDPKGAFSIDPR-----SGWLTVRNQTVLDREAHSSLRMKVYAKE-TNP 388
G N + Y+L +P F +D + + +L + + LDRE R+ V A + P
Sbjct: 161 IGANAQLRYRL-NPNEYFDLDVKTNEEETNFLELVLRKSLDREETQEHRLLVIATDGGKP 219
Query: 389 SVVGT 393
+ GT
Sbjct: 220 ELTGT 224
>BC111560-1|AAI11561.1| 1040|Homo sapiens protocadherin 10 protein.
Length = 1040
Score = 109 bits (263), Expect = 6e-23
Identities = 125/494 (25%), Positives = 201/494 (40%), Gaps = 48/494 (9%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E + E + VE+ +LD NDN P F +L + +A GT A DPD+G
Sbjct: 94 HLEVFLENPLELFQVEIEVLDINDNPPSFPEPDL-TVEISESATPGTRFPLESAFDPDVG 152
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPAN--- 544
N + Y++ S ++ + + N V E P+ + H + A D
Sbjct: 153 TNSLRDYEITPNSYFSLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGV 212
Query: 545 -------------PSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTS 591
P ++R A++TI V + ++P F Y + N GT
Sbjct: 213 GEGGGGGGGAGLPPQQQRTGTALLTIRVL----DSNDNVPAFDQPVYTVSLPENSPPGTL 268
Query: 592 VGQIRVNDAFE-QN-DVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEA 647
V Q+ D E QN +V Y F + R+G + V +L P+Y
Sbjct: 269 VIQLNATDPDEGQNGEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYV 328
Query: 648 VALQENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMS 706
A N + V V+D ND + + S + V E +A + +F
Sbjct: 329 QAKDLGPNAVPAHCKVLVRVLDANDNAPEI---SFSTVKEAVSEGAAPGTVVALFSVTDR 385
Query: 707 SIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVIS 766
NG V+ + + TI T+ PLDRE D Y +TV+A ++G +
Sbjct: 386 DSEENG--QVQCELLGDVPFRPKSSFKNYYTIVTEAPLDREAGDSYTLTVVAR-DRGEPA 442
Query: 767 GAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFM 826
+ + + + D NDN P F Y+ ++ EN+ G I + ATD DEG NA
Sbjct: 443 LSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYA---VSATDRDEGANAQLA 499
Query: 827 YTLFG---EGKEMF---DVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG---LSSEA 877
Y++ +G +F ++ G + + S D E+ + + ARD G L+ A
Sbjct: 500 YSILECQIQGMSVFTYVSINSENGYLYALR-SFDYEQLKDFSFQVEARDAGSPQALAGNA 558
Query: 878 ELIIMIGDENDNKP 891
+ I+I D+NDN P
Sbjct: 559 TVNILIVDQNDNAP 572
Score = 109 bits (261), Expect = 1e-22
Identities = 120/429 (27%), Positives = 179/429 (41%), Gaps = 45/429 (10%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
E G ++ + +DRE+ + + + + ++QV I + D NDNPP F
Sbjct: 69 ETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELFQVEIEVLDINDNPPSFPEPDLT 128
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDV----DENTGVVKFI 849
I E++ GT +++ A D D GTN+L Y + DV D N +
Sbjct: 129 VEISESATPGTRFPLES---AFDPDVGTNSLRDYEITPNSYFSLDVQTQGDGNRFAELVL 185
Query: 850 GDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETK 909
LDRE++ +++ L A D GG +G+ + + +
Sbjct: 186 EKPLDREQQAVHRYVLTAVDGGGGGG-------VGEGGGG---------GGGAGLPPQQQ 229
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
GTA TI V N DQ +PEN P GT +I+LNA D D G NG++ Y
Sbjct: 230 RTGTALLTI-RVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYS 288
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALD-GGN-L 1025
F+S +I P + F ++ R G + V+ L E +++ + A D G N +
Sbjct: 289 FSS--HISP--------RARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAV 338
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQ 1085
+ V V V D ND+ P + V E V+ TD D +N + +
Sbjct: 339 PAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELL 398
Query: 1086 PSDTDLPFE-ISPLTGVLSVNGE--LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXX 1142
D+PF S ++ E LDRE D Y LTVVARD G
Sbjct: 399 ---GDVPFRPKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRG-EPALSTSKSIQVQVS 454
Query: 1143 DVNDNSPKF 1151
DVNDN+P+F
Sbjct: 455 DVNDNAPRF 463
Score = 85.8 bits (203), Expect = 1e-15
Identities = 116/464 (25%), Positives = 190/464 (40%), Gaps = 46/464 (9%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLT 506
+ +LD+NDN P F +Y S+ N+ GT++ ++ A DPD GQNG V+Y +
Sbjct: 238 IRVLDSNDNVPAF-DQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPR 296
Query: 507 ITSPFKINPNTGTVSVA------ESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVT 560
F ++P TG + V+ ESP+ + ++V+A D N + V ++
Sbjct: 297 ARELFGLSPRTGRLEVSGELDYEESPV----YQVYVQAKDLGPNAVPAHCKVLVRVLD-- 350
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
N P+I F G+ G ++ + D+ E V +LL VPF
Sbjct: 351 --ANDNAPEI-SFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELL----GDVPF 403
Query: 621 AVEER-SGVITVVDD--LSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVDVNDERGVL 676
+ T+V + L R Y VA LS + V V DVND
Sbjct: 404 RPKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRF 463
Query: 677 LKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ----DVTDDIAI 732
+ + ++ + N GA I + T+ + + I Q V ++I
Sbjct: 464 SQPVYD--VYVTENNVPGAYIYAVSATDRDE---GANAQLAYSILECQIQGMSVFTYVSI 518
Query: 733 -AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVF---- 787
+E+G ++ + D E+ + V A + AG V I I D+NDN P
Sbjct: 519 NSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPL 578
Query: 788 --EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG 844
+ T ++ S + + A DAD+G NA Y++ G +F +D TG
Sbjct: 579 PGRNGTPAREVLPRS--AEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRTG 636
Query: 845 VVKFIGD-SLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
++ R+ + Y+L + RD G LSS A L++ + D
Sbjct: 637 ELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVD 680
Score = 74.1 bits (174), Expect = 3e-12
Identities = 42/111 (37%), Positives = 61/111 (54%), Gaps = 7/111 (6%)
Query: 286 KTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+T A + I +LD NDN+P F+ Y +S+ EN P G V+Q+ ATD D+G+NGE Y
Sbjct: 230 RTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSF 289
Query: 346 D---DPKG--AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVV 391
P+ F + PR+G L V + LD E ++ V AK+ P+ V
Sbjct: 290 SSHISPRARELFGLSPRTGRLEVSGE--LDYEESPVYQVYVQAKDLGPNAV 338
Score = 64.5 bits (150), Expect = 3e-09
Identities = 52/182 (28%), Positives = 78/182 (42%), Gaps = 14/182 (7%)
Query: 218 IHAIDQDLGVGATLRYEL---ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
++A D D G + Y IS R+LF L G L + ELD + ++ + +
Sbjct: 272 LNATDPDEGQNGEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYE-----ESPVYQV 326
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
VQA L A +V + +LD NDN PE ++ E G V TD+D
Sbjct: 327 YVQAKDLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRD 386
Query: 335 QGENGEFTYQLDDPKGAFSIDPRS---GWLTVRNQTVLDREAHSSLRMKVYAKETNPSVV 391
ENG+ +L G P+S + T+ + LDREA S + V A++ +
Sbjct: 387 SEENGQVQCEL---LGDVPFRPKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPAL 443
Query: 392 GT 393
T
Sbjct: 444 ST 445
Score = 61.3 bits (142), Expect = 3e-08
Identities = 62/223 (27%), Positives = 84/223 (37%), Gaps = 22/223 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ E GT + + D DS NGQ++ E +V P K Y+ I
Sbjct: 367 VSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVPFRPKS------SFKNYYTI----- 415
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+ L E+ + L + A D G L+ + S++V V DVND+ P F + Y+ V
Sbjct: 416 --VTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVT 473
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYF-----IQPSDTDLPFEISPLTGVLSVNGELDR 1110
E + V ATD D G NA L Y IQ I+ G L D
Sbjct: 474 ENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSINSENGYLYALRSFDY 533
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYA 1153
E + V ARD G D NDN+P A
Sbjct: 534 EQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVA 576
Score = 57.6 bits (133), Expect = 3e-07
Identities = 55/204 (26%), Positives = 85/204 (41%), Gaps = 23/204 (11%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
+++ N+P G I ++A D D G N Q+ Y + + V Y IN
Sbjct: 470 VYVTENNVP-GAYIYAVSATDRDEGANAQLAYSI--------LECQIQGMSVFTYVSINS 520
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFKKTWYN 1051
+G++ RS E +F + A D G+ L N +V + + D ND+ P
Sbjct: 521 ENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPG 580
Query: 1052 FNVEEAQYTRR-------VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSV 1104
N A+ +L +V A DAD G+NA LTY I + F + TG L
Sbjct: 581 RNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRT 640
Query: 1105 NGEL--DRETEDKYILTVVARDNG 1126
+ R+ + Y L + RD+G
Sbjct: 641 ARRVPAKRDPQRPYELVIEVRDHG 664
Score = 57.2 bits (132), Expect = 4e-07
Identities = 73/293 (24%), Positives = 122/293 (41%), Gaps = 29/293 (9%)
Query: 71 GAGL---NQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF-IFLIAPI-G 125
GAGL Q + +T+ + D NDNVP F Y V++ E +P G + P G
Sbjct: 221 GAGLPPQQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEG 280
Query: 126 PSLTIPLTV-----PRGLTIF----KDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALES 176
+ + + PR +F + R + + S V+ V D G A+ +
Sbjct: 281 QNGEVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPA 340
Query: 177 SHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGATLR 232
H VL+ +VLD + E + ++ K E P + A+ D+D ++
Sbjct: 341 -HCKVLV--RVLDANDNAPE---ISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQ 394
Query: 233 YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV 292
EL+ D S + E LD E +++ L V A P + +
Sbjct: 395 CELLG--DVPFRPKSSFKNYYTIVTEAPLDRE---AGDSYTLTVVARDRGEPALSTSKSI 449
Query: 293 EIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
++++ D+NDN P F Y++ + EN G + V ATD+D+G N + Y +
Sbjct: 450 QVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSI 502
Score = 56.0 bits (129), Expect = 1e-06
Identities = 45/162 (27%), Positives = 71/162 (43%), Gaps = 6/162 (3%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G + LD E+ VY++ V A+ + G + +V + + D NDN P +T +
Sbjct: 308 GRLEVSGELDYEESPVYQVYVQAK-DLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEA 366
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
+ E + GT + + ++ TD D N L G+ LDR
Sbjct: 367 VSEGAAPGTVVALFSV---TDRDSEENGQVQCELLGDVPFRPKSSFKNYYTIVTEAPLDR 423
Query: 856 EKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ 895
E Y L++VARD G LS+ + + + D NDN P F+Q
Sbjct: 424 EAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQ 465
Score = 54.8 bits (126), Expect = 2e-06
Identities = 77/336 (22%), Positives = 128/336 (38%), Gaps = 30/336 (8%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI----APIGPSL 128
G N + A+ V V + D NDN P + V E G +F + + +
Sbjct: 334 GPNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQV 393
Query: 129 TIPLT--VP-RGLTIFKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLL 184
L VP R + FK+ + P + Y++ V D G AL +S + +
Sbjct: 394 QCELLGDVPFRPKSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQV 453
Query: 185 RKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKL- 243
V D + + + + ++ + A D+D G A L Y ++ + +
Sbjct: 454 SDVNDNAPRFSQPVYDVYVTENNVPGAYIYA--VSATDRDEGANAQLAYSILECQIQGMS 511
Query: 244 ----FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTA-QARVEIELLD 298
S++S NG L+ + D + Q F QV+A +P A A V I ++D
Sbjct: 512 VFTYVSINSENGYLYALRSFDYE-----QLKDFSFQVEARDAGSPQALAGNATVNILIVD 566
Query: 299 LNDNLPEFEVDF---YNISIVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPK 349
NDN P E LP G+ + +V A D D GEN TY + +
Sbjct: 567 QNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEM 626
Query: 350 GAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
F +D R+G L + R+ + + ++
Sbjct: 627 NLFRMDWRTGELRTARRVPAKRDPQRPYELVIEVRD 662
Score = 49.2 bits (112), Expect = 1e-04
Identities = 41/139 (29%), Positives = 67/139 (48%), Gaps = 9/139 (6%)
Query: 221 IDQDLGVGATLR----YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
I +DLG+ T ++ + + L+ G L++ +++D + + Q+ + VL +
Sbjct: 37 IAEDLGLDITKLSARGFQTVPNSRTPYLDLNLETGVLYVNEKIDRE-QICKQSPSCVLHL 95
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+ L NPL+ Q VEIE+LD+NDN P F + I E+ G A D D G
Sbjct: 96 EVF-LENPLELFQ--VEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVG 152
Query: 337 ENGEFTYQLDDPKGAFSID 355
N Y++ P FS+D
Sbjct: 153 TNSLRDYEI-TPNSYFSLD 170
Score = 44.0 bits (99), Expect = 0.004
Identities = 41/151 (27%), Positives = 64/151 (42%), Gaps = 24/151 (15%)
Query: 1233 SSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKM 1290
+ TA+L + V D D V D+PV Y + + EN ++ LN T+ E N ++
Sbjct: 231 TGTALLTIRVLDSNDNVPAFDQPV-----YTVSLPENSPPGTLVIQLNATDPDEGQNGEV 285
Query: 1291 RYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYP 1350
Y + R F + PR G L + D E Y+V V+
Sbjct: 286 VYSFSSHISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQ---------------- 329
Query: 1351 VAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
A+D+ KV+VR+ D NDN+P+ +
Sbjct: 330 -AKDLGPNAVPAHCKVLVRVLDANDNAPEIS 359
Score = 35.5 bits (78), Expect = 1.5
Identities = 35/113 (30%), Positives = 59/113 (52%), Gaps = 11/113 (9%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P+LS++ + V V+DV D +PV Y++ + EN + +++ T+ E
Sbjct: 439 GEPALSTSKSIQVQVSDVNDNAPRFSQPV-----YDVYVTENNVPGAYIYAVSATDRDEG 493
Query: 1287 -NFKMRYYILNENDTDIR-RTFV-IDPRNGTLYLVRSPDRE-VKD-TYEVIVR 1334
N ++ Y IL + T+V I+ NG LY +RS D E +KD +++V R
Sbjct: 494 ANAQLAYSILECQIQGMSVFTYVSINSENGYLYALRSFDYEQLKDFSFQVEAR 546
Score = 35.1 bits (77), Expect = 2.0
Identities = 82/374 (21%), Positives = 138/374 (36%), Gaps = 40/374 (10%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD-- 1088
V + V D+ND+ P F + + E+ A D D G N+ Y I P+
Sbjct: 108 VEIEVLDINDNPPSFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYF 167
Query: 1089 -TDLPFE-ISPLTGVLSVNGELDRETE--DKYILTVVARDNGXXXXXXXXXXXXXXXXDV 1144
D+ + L + LDRE + +Y+LT V G
Sbjct: 168 SLDVQTQGDGNRFAELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQ 227
Query: 1145 NDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDT 1204
+ +L+ SN N + PVY ++ EN+P GT V ++ A D
Sbjct: 228 QQRTGTALLTIRVLD---------SNDNVPAFDQ-PVYTVSLPENSPPGTLVIQLNATDP 277
Query: 1205 DFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYEL 1264
D NG ++YS + + L LS + +V E++ + PV+
Sbjct: 278 D--EGQNGEVVYSFSSHISPRARELFGLSPRTGRL----EVSGELDYEESPVYQVYVQAK 331
Query: 1265 EIEENV-----NAPVELVSLNLTEHYENFKMRYYILNEN---DTDIRRTFVID---PRNG 1313
++ N V ++ N +F ++E T + V D NG
Sbjct: 332 DLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENG 391
Query: 1314 TL---YLVRSPDR---EVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVV 1367
+ L P R K+ Y ++ A + + + + + VA D E +
Sbjct: 392 QVQCELLGDVPFRPKSSFKNYYTIVTEAPLDREAGD-SYTLTVVARDRGEPALSTSKSIQ 450
Query: 1368 VRIKDVNDNSPKFT 1381
V++ DVNDN+P+F+
Sbjct: 451 VQVSDVNDNAPRFS 464
Score = 34.3 bits (75), Expect = 3.4
Identities = 21/81 (25%), Positives = 40/81 (49%), Gaps = 3/81 (3%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A+D D G A L Y ++ GN+ LF +D G L + + A+ + Q + L ++
Sbjct: 603 VAAVDADDGENARLTYSIVRGNEMNLFRMDWRTGELRTARR--VPAKRDPQ-RPYELVIE 659
Query: 278 ASQLNNPLKTAQARVEIELLD 298
P ++ A + ++L+D
Sbjct: 660 VRDHGQPPLSSTATLVVQLVD 680
Score = 33.1 bits (72), Expect = 7.9
Identities = 23/93 (24%), Positives = 43/93 (46%), Gaps = 9/93 (9%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
+ L V + ++D NDN P V + +A+ G ++ +V AVD D G
Sbjct: 552 QALAGNATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDG 611
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVA 523
+N + Y + R + + + F+++ TG + A
Sbjct: 612 ENARLTYSIVRGNEMNL---FRMDWRTGELRTA 641
>AB025106-1|BAA88957.1| 901|Homo sapiens E-cadherin protein.
Length = 901
Score = 109 bits (263), Expect = 6e-23
Identities = 132/473 (27%), Positives = 197/473 (41%), Gaps = 55/473 (11%)
Query: 701 FHTNMSSIYGNGT--GNVRFLIANQQDVTDDIAI----AEDGTIFTQKPLDREKRDVYRM 754
F N+ I N G V + I Q T + + E G + +PLDRE+ Y +
Sbjct: 171 FPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTL 230
Query: 755 TVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKA 814
A + G + ++ I + D+NDN P F ++G +ME + GT + M+ + A
Sbjct: 231 FSHAVSSNGNAVEDPM-EILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSV-ME--VTA 286
Query: 815 TDADEGT---NALFMYTLFGE-----GKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLV 866
TDAD+ NA YT+ + K MF ++ NTGV+ + LDRE Y L +
Sbjct: 287 TDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQ 346
Query: 867 ARDT--GGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV--K 922
A D GLS+ A +I + D NDN P FN +V + + T T +
Sbjct: 347 AADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAPNT 406
Query: 923 PKNKFALDV-DQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
P + + + G F++ N P+ I A DL N + +S Y P L
Sbjct: 407 PAWEAVYTILNDDGGQFVVTTN-PVNNDGILKTAKDLARCRN----WHPHSCSY--PCPL 459
Query: 982 SADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDH 1041
D E K+ +++ HV V +P F ++++ +V V V DVN+
Sbjct: 460 GLD-FEAKQQYIL-----HVAVTNVVP----FEVSLT-------TSTATVTVDVLDVNE- 501
Query: 1042 FPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGV 1101
P+F V E + + A + D +TY I DT EI+P TG
Sbjct: 502 APIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIW-RDTANWLEINPDTGA 560
Query: 1102 LSVNGELDRE-----TEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
+S ELDRE Y ++A DNG DVNDN+P
Sbjct: 561 ISTRAELDREDFEHVKNSTYTALIIATDNG-SPVATGTGTLLLILSDVNDNAP 612
Score = 54.4 bits (125), Expect = 3e-06
Identities = 53/172 (30%), Positives = 74/172 (43%), Gaps = 13/172 (7%)
Query: 992 FVINERHGHVIVARSLPPE--SEFRLNISAL--DGGNLNDNISVRVFVKDVNDHFPVFKK 1047
F+I G + V L E + + L A+ +G + D + + + V D ND+ P F +
Sbjct: 205 FIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQ 264
Query: 1048 TWYNFNVEEAQYTRRVLGKVDATDADFG---QNANLTYFIQPSDTDLP----FEISPLTG 1100
+ +V E + +V ATDAD NA + Y I D +LP F I+ TG
Sbjct: 265 EVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTG 324
Query: 1101 VLS-VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
V+S V LDRE+ Y L V A D D NDN P F
Sbjct: 325 VISVVTTGLDRESFPTYTLVVQAADL-QGEGLSTTATAVITVTDTNDNPPIF 375
Score = 48.0 bits (109), Expect = 3e-04
Identities = 96/386 (24%), Positives = 153/386 (39%), Gaps = 50/386 (12%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPD---LGQNGMVLYD- 498
+ + +T+ D NDN P F +++ S+ A GT + +V A D D N + Y
Sbjct: 246 MEILITVTDQNDNKPEFT-QEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTI 304
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILE---GRHALFVEASDQPANPSERRYSLAVV 555
L + L + F IN NTG +SV + + + L V+A+D E + A
Sbjct: 305 LSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADL---QGEGLSTTATA 361
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGY- 614
I VT T N P F Y+ V N + ++V DA N +++ ++
Sbjct: 362 VITVT-DTNDNP---PIFNPTTYKGQVPENEA-NVVITTLKVTDADAPNTPAWEAVYTIL 416
Query: 615 -EEGVPFAVE----ERSGVITVVDDLSR----------YNRPM-YDFEAVALQENANLSI 658
++G F V G++ DL+R Y P+ DFE A Q+
Sbjct: 417 NDDGGQFVVTTNPVNNDGILKTAKDLARCRNWHPHSCSYPCPLGLDFE--AKQQYILHVA 474
Query: 659 VTNATVHVVDVNDERGV----LLKGAHSPIIFHVK---ENSAGAAIGQIFHTNMSSIYGN 711
VTN V + +L +PI + E S +GQ T+ ++ +
Sbjct: 475 VTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEI-TSYTAQEPD 533
Query: 712 GTGNVRFLIANQQDVTDDIAIAED-GTIFTQKPLDRE-----KRDVYRMTVIAEFNKGVI 765
+ +D + + I D G I T+ LDRE K Y +IA N +
Sbjct: 534 TFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPV 593
Query: 766 SGAGIYQVTIYIEDENDNPPVFEHAT 791
+ G + + + D NDN P+ E T
Sbjct: 594 A-TGTGTLLLILSDVNDNAPIPEPRT 618
Score = 47.6 bits (108), Expect = 3e-04
Identities = 40/134 (29%), Positives = 60/134 (44%), Gaps = 10/134 (7%)
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
T+ L A N + I + D NDN PEF + + S++E G SV++V A
Sbjct: 227 TYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTA 286
Query: 331 TDKDQGENG-----EFTYQLDDP----KGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKV 381
TD D N +T DP K F+I+ +G ++V T LDRE+ + + V
Sbjct: 287 TDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVT-TGLDRESFPTYTLVV 345
Query: 382 YAKETNPSVVGTFA 395
A + + T A
Sbjct: 346 QAADLQGEGLSTTA 359
Score = 46.0 bits (104), Expect = 0.001
Identities = 54/231 (23%), Positives = 88/231 (38%), Gaps = 15/231 (6%)
Query: 620 FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDERGVLLK 678
F +E +G + V + L R Y + A+ N N + + V D ND + +
Sbjct: 205 FIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQ 264
Query: 679 GAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI----AE 734
+ ++ G ++ ++ T+ + + I +Q D +
Sbjct: 265 EVFKGSV--MEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRN 322
Query: 735 DGTI-FTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
G I LDRE Y + V A +G V I + D NDNPP+F TY+
Sbjct: 323 TGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAV-ITVTDTNDNPPIFNPTTYK 381
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALF--MYTLFGEGKEMFDVDEN 842
G + EN + I +K TDAD + +YT+ + F V N
Sbjct: 382 GQVPEN-EANVVI---TTLKVTDADAPNTPAWEAVYTILNDDGGQFVVTTN 428
Score = 35.9 bits (79), Expect = 1.1
Identities = 74/307 (24%), Positives = 118/307 (38%), Gaps = 41/307 (13%)
Query: 222 DQDLGV-GATLRYELISGN----DRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
D D+ A + Y ++S + D+ +F+++ G + + LD E T+ L V
Sbjct: 290 DDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTT-GLDRE---SFPTYTLVV 345
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN-GFSVLQVMATDKDQ 335
QA+ L + A I + D NDN P F Y + EN N + L+V D
Sbjct: 346 QAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAPN 405
Query: 336 GENGEFTYQ-LDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGTF 394
E Y L+D G F + V N +L + A R + + +
Sbjct: 406 TPAWEAVYTILNDDGGQFVVTTN----PVNNDGIL-KTAKDLARCRNWHPHSCSYPCPLG 460
Query: 395 ADSQRIAKWRRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDAND 454
D + ++ TN V P +V T + V V+V LD N+
Sbjct: 461 LDFEAKQQYILHVAVTN--------VVPFEVSLTTST---------ATVTVDV--LDVNE 501
Query: 455 NNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKIN 514
P+FVP + + VG I A +PD + Y + R + + +IN
Sbjct: 502 -APIFVPPE-KRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDT----ANWLEIN 555
Query: 515 PNTGTVS 521
P+TG +S
Sbjct: 556 PDTGAIS 562
>BC071934-1|AAH71934.1| 798|Homo sapiens protocadherin beta 13
protein.
Length = 798
Score = 109 bits (262), Expect = 7e-23
Identities = 136/507 (26%), Positives = 224/507 (44%), Gaps = 63/507 (12%)
Query: 929 LDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
+D++ P+FL + E+ P GTT NA DLD G N N E YI
Sbjct: 125 IDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQN-------NIENYIISPNS 177
Query: 982 SADALEVKRYFVINERHGHVIVARSLP--PESEFRLNISALDGGNLNDNISVRVFVK--D 1037
L KR ++ +++ ++L E+E RL ++ALDGG+ + + +V+++ D
Sbjct: 178 YFRVLTRKRSD--GRKYPELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLD 235
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDL--PFEI 1095
VND+ P F++ +Y + E ++ KV ATD D G N ++Y + + ++ F+I
Sbjct: 236 VNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQASEEIGKTFKI 295
Query: 1096 SPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK--FYA 1153
+PLTG + + +LD E Y + + ARD G DVND++P+ A
Sbjct: 296 NPLTGEIELKKQLDFEKLQSYEVNIEARDAG---TFSGKCTVLIQVIDVNDHAPEVTMSA 352
Query: 1154 FDELLEWKHPE--ADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFAN-DTDFIGNG 1210
F + PE S + +S + +I+E+ P A+ F T+ +
Sbjct: 353 FTSPIPENAPETVVALFSVSDLDSGENGKI-SCSIQEDLPFLLKSAENFYTLLTERPLDR 411
Query: 1211 NGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV 1270
Y++ +LG P L + + V +ADV D + P F Y L + EN
Sbjct: 412 ESRAEYNI--TITVTDLGTPMLITQLNMTVLIADVND-----NAPAFTQTSYTLFVRENN 464
Query: 1271 NAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREVK 1326
+ + + S++ T+ N ++ Y +L D + T + I+ NG L+ +RS D E
Sbjct: 465 SPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSLVSINADNGHLFALRSLDYEAL 524
Query: 1327 DTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTN 1382
++ V A H ++ + L V+VVV D NDNSP N
Sbjct: 525 QGFQFRVGAS--------DHGSPALSSEAL-------VRVVV--LDANDNSPFVLYPLQN 567
Query: 1383 GNRPLVTAIPTTAPFGYQVMQLKGAIG 1409
G+ P +P A GY V ++ G
Sbjct: 568 GSAPCTELVPRAAEPGYLVTKVVAVDG 594
Score = 106 bits (255), Expect = 5e-22
Identities = 122/471 (25%), Positives = 198/471 (42%), Gaps = 39/471 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E F E+ ++D ND++PVF+ + + ++ GT A D D+GQN +
Sbjct: 112 ESPFEFFQAELQVIDINDHSPVFLDKQML-VKVSESSPPGTTFPLKNAEDLDVGQNNIEN 170
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHA---LFVEASDQPANPSERRYSLA 553
Y + S + + + + V + + A L + A D + P R A
Sbjct: 171 YIISPNSYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTALDGGSPP---RSGTA 227
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLL 611
V IEV + P+F Y + + +G V ++ D ++SY L
Sbjct: 228 QVYIEVL----DVNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLF 283
Query: 612 HGYEE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
EE G F + +G I + L Y+ A ++ S + V+DVN
Sbjct: 284 QASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEA-RDAGTFSGKCTVLIQVIDVN 342
Query: 671 DERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D V + SPI EN+ + +F ++S + G + I Q+D+
Sbjct: 343 DHAPEVTMSAFTSPI----PENAPETVVA-LF--SVSDLDSGENGKISCSI--QEDLPFL 393
Query: 730 IAIAEDG-TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ AE+ T+ T++PLDRE R Y +T+ + G +T+ I D NDN P F
Sbjct: 394 LKSAENFYTLLTERPLDRESRAEYNITITVT-DLGTPMLITQLNMTVLIADVNDNAPAFT 452
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDEN 842
+Y F+ EN+ I+ + ATD D GTNA Y+L + ++ +
Sbjct: 453 QTSYTLFVRENNSPALHIRS---VSATDRDSGTNAQVTYSLLPPQDPHLPLTSLVSINAD 509
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
G + F SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 510 NGHL-FALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSP 559
Score = 85.4 bits (202), Expect = 1e-15
Identities = 71/245 (28%), Positives = 111/245 (45%), Gaps = 21/245 (8%)
Query: 911 NGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEF 970
+GTA IEV N A + +Q I E+ P+G ++K++A D+D+G+NG+I Y
Sbjct: 224 SGTAQ-VYIEVLDVNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISY-- 280
Query: 971 NSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDN 1028
L + E+ + F IN G + + + L E + +NI A D G +
Sbjct: 281 ---------SLFQASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGTFSGK 331
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
+V + V DVNDH P + + + E V+ +D D G+N ++ IQ
Sbjct: 332 CTVLIQVIDVNDHAPEVTMSAFTSPIPE-NAPETVVALFSVSDLDSGENGKISCSIQ--- 387
Query: 1089 TDLPFEISPLTGVLSVNGE--LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
DLPF + ++ E LDRE+ +Y +T+ D G DVND
Sbjct: 388 EDLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLG-TPMLITQLNMTVLIADVND 446
Query: 1147 NSPKF 1151
N+P F
Sbjct: 447 NAPAF 451
Score = 83.4 bits (197), Expect = 6e-15
Identities = 52/137 (37%), Positives = 78/137 (56%), Gaps = 11/137 (8%)
Query: 253 LFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN 312
L L+K LD + E L+ L + A +P ++ A+V IE+LD+NDN PEFE FY
Sbjct: 195 LVLDKALDREEEAELR-----LTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQPFYR 249
Query: 313 ISIVENLPNGFSVLQVMATDKDQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTV 368
+ I E+ P GF V++V ATD D G NGE +Y L ++ F I+P +G + ++ Q
Sbjct: 250 VQISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQASEEIGKTFKINPLTGEIELKKQ-- 307
Query: 369 LDREAHSSLRMKVYAKE 385
LD E S + + A++
Sbjct: 308 LDFEKLQSYEVNIEARD 324
Score = 83.0 bits (196), Expect = 7e-15
Identities = 71/239 (29%), Positives = 111/239 (46%), Gaps = 19/239 (7%)
Query: 662 ATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLI 720
A + V+D+ND V L ++ V E+S G F + G N+ ++I
Sbjct: 120 AELQVIDINDHSPVFLD---KQMLVKVSESSPP---GTTFPLKNAEDLDVGQNNIENYII 173
Query: 721 ANQQDVTDDIAIAEDGTIFTQ----KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIY 776
+ DG + + K LDRE+ R+T+ A + G +G QV I
Sbjct: 174 SPNSYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTA-LDGGSPPRSGTAQVYIE 232
Query: 777 IEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM 836
+ D NDN P FE Y I E+S +G + + ATD D G N Y+LF +E+
Sbjct: 233 VLDVNDNAPEFEQPFYRVQISEDSPVGFLVVK---VSATDVDTGVNGEISYSLFQASEEI 289
Query: 837 ---FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
F ++ TG ++ + LD EK Y++++ ARD G S + ++I + D ND+ PE
Sbjct: 290 GKTFKINPLTGEIE-LKKQLDFEKLQSYEVNIEARDAGTFSGKCTVLIQVIDVNDHAPE 347
Score = 72.1 bits (169), Expect = 1e-11
Identities = 70/237 (29%), Positives = 97/237 (40%), Gaps = 17/237 (7%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
+I+V N A +V IPEN P T + + DLDSG NG+I + +P
Sbjct: 335 LIQVIDVNDHAPEVTMSAFTSPIPENAP-ETVVALFSVSDLDSGENGKISCSIQED--LP 391
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVFVKD 1037
SA+ Y ++ ER + R E + ++ L L +++ V + D
Sbjct: 392 FLLKSAENF----YTLLTERP----LDRESRAEYNITITVTDLGTPMLITQLNMTVLIAD 443
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSDTDLPF--- 1093
VND+ P F +T Y V E + V ATD D G NA +TY + P D LP
Sbjct: 444 VNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSL 503
Query: 1094 -EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
I+ G L LD E + V A D+G D NDNSP
Sbjct: 504 VSINADNGHLFALRSLDYEALQGFQFRVGASDHG-SPALSSEALVRVVVLDANDNSP 559
Score = 63.3 bits (147), Expect = 6e-09
Identities = 82/328 (25%), Positives = 137/328 (41%), Gaps = 30/328 (9%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP------SLTIP 131
S +V + + DVND+ P + + + E P A +F ++ + S +I
Sbjct: 329 SGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENAPETVVA-LFSVSDLDSGENGKISCSIQ 387
Query: 132 LTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDY 190
+P L ++ ++P S Y+I ++ D G L + +L+ V D
Sbjct: 388 EDLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIADVNDN 447
Query: 191 DAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLFS 245
+ + + + L + A D+D G A + Y L+ D L S
Sbjct: 448 APAFTQTSYTLFV--RENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSLVS 505
Query: 246 LDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPE 305
+++ NG LF + LD +A LQ F +V AS +P +++A V + +LD NDN P
Sbjct: 506 INADNGHLFALRSLDYEA---LQG--FQFRVGASDHGSPALSSEALVRVVVLDANDNSPF 560
Query: 306 FEVDFYNIS--IVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPR 357
N S E +P G+ V +V+A D D G+N +YQL G F +
Sbjct: 561 VLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAH 620
Query: 358 SGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+G VR +L + R+ V K+
Sbjct: 621 NG--EVRTARLLSERDAAKHRLVVLVKD 646
Score = 57.6 bits (133), Expect = 3e-07
Identities = 60/201 (29%), Positives = 88/201 (43%), Gaps = 21/201 (10%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
LF+ N P I ++A D DSG N Q+ Y +PP L + IN
Sbjct: 458 LFVRENNSP-ALHIRSVSATDRDSGTNAQVTYSL-----LPPQD---PHLPLTSLVSINA 508
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+GH+ RSL E+ F+ + A D G+ L+ VRV V D ND+ P N
Sbjct: 509 DNGHLFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSPFVLYPLQNG 568
Query: 1053 NVEEAQYTRR------VLGKVDATDADFGQNANLTY-FIQPSDTDLPFEISPLTGVLSVN 1105
+ + R ++ KV A D D GQNA L+Y ++ ++ L F + G +
Sbjct: 569 SAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGL-FGVWAHNGEVRTA 627
Query: 1106 GELDRETEDKYILTVVARDNG 1126
L K+ L V+ +DNG
Sbjct: 628 RLLSERDAAKHRLVVLVKDNG 648
Score = 52.8 bits (121), Expect = 9e-06
Identities = 63/244 (25%), Positives = 105/244 (43%), Gaps = 21/244 (8%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
E + + LDRE + + F + S +Q + + D ND+ PVF
Sbjct: 81 ETADLLLNEKLDREDLCGHTEPCVLRFQVLLESPFEFFQAELQVIDINDHSPVFLDKQML 140
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----I 849
+ E+S GT + N A D D G N + Y + + + K+ +
Sbjct: 141 VKVSESSPPGTTFPLKN---AEDLDVGQNNIENYIISPNSYFRVLTRKRSDGRKYPELVL 197
Query: 850 GDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRE 907
+LDRE++ +L+L A D G S A++ I + D NDN PEF Q +V+I +
Sbjct: 198 DKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQ--PFYRVQISED 255
Query: 908 TKLNGTAGFTIIEVKPKNKFALDVDQLGPL--FLIPENIPIGTTIIKLNALDLDSGLNGQ 965
+ + GF +++V + +D G + L + IG T K+N L + L Q
Sbjct: 256 SPV----GFLVVKVSATD---VDTGVNGEISYSLFQASEEIGKT-FKINPLTGEIELKKQ 307
Query: 966 IRYE 969
+ +E
Sbjct: 308 LDFE 311
Score = 46.4 bits (105), Expect = 8e-04
Identities = 38/121 (31%), Positives = 48/121 (39%), Gaps = 5/121 (4%)
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFE 1094
V D+NDH PVF V E+ +A D D GQN Y I P+
Sbjct: 124 VIDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENYIISPNSYFRVLT 183
Query: 1095 ISPLTG----VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
G L ++ LDRE E + LT+ A D G DVNDN+P+
Sbjct: 184 RKRSDGRKYPELVLDKALDREEEAELRLTLTALDGG-SPPRSGTAQVYIEVLDVNDNAPE 242
Query: 1151 F 1151
F
Sbjct: 243 F 243
Score = 42.7 bits (96), Expect = 0.010
Identities = 39/126 (30%), Positives = 55/126 (43%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 541 LSSEALVRVVVLDANDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 599
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + L + + N T + S +H L V D P +L
Sbjct: 600 AWLSYQLLKATELGLFGVWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 658
Query: 553 AVVTIE 558
V+ ++
Sbjct: 659 HVLLVD 664
Score = 35.1 bits (77), Expect = 2.0
Identities = 38/154 (24%), Positives = 67/154 (43%), Gaps = 10/154 (6%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
++S ++ L+ L L ++LD + VL+ Q L +P + QA E+
Sbjct: 67 VVSRGNKLHLQLNQETADLLLNEKLDREDLCG-HTEPCVLRFQVL-LESPFEFFQA--EL 122
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
+++D+ND+ P F + + E+ P G + A D D G+N Y + P F +
Sbjct: 123 QVIDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENY-IISPNSYFRV 181
Query: 355 DPRS-----GWLTVRNQTVLDREAHSSLRMKVYA 383
R + + LDRE + LR+ + A
Sbjct: 182 LTRKRSDGRKYPELVLDKALDREEEAELRLTLTA 215
Score = 33.5 bits (73), Expect = 6.0
Identities = 16/36 (44%), Positives = 20/36 (55%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE 108
G + L++TV I DVNDN P F T Y + V E
Sbjct: 427 GTPMLITQLNMTVLIADVNDNAPAFTQTSYTLFVRE 462
>BC051348-1|AAH51348.1| 798|Homo sapiens protocadherin beta 13
protein.
Length = 798
Score = 109 bits (262), Expect = 7e-23
Identities = 136/507 (26%), Positives = 224/507 (44%), Gaps = 63/507 (12%)
Query: 929 LDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
+D++ P+FL + E+ P GTT NA DLD G N N E YI
Sbjct: 125 IDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQN-------NIENYIISPNS 177
Query: 982 SADALEVKRYFVINERHGHVIVARSLP--PESEFRLNISALDGGNLNDNISVRVFVK--D 1037
L KR ++ +++ ++L E+E RL ++ALDGG+ + + +V+++ D
Sbjct: 178 YFRVLTRKRSD--GRKYPELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLD 235
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDL--PFEI 1095
VND+ P F++ +Y + E ++ KV ATD D G N ++Y + + ++ F+I
Sbjct: 236 VNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQASEEIGKTFKI 295
Query: 1096 SPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK--FYA 1153
+PLTG + + +LD E Y + + ARD G DVND++P+ A
Sbjct: 296 NPLTGEIELKKQLDFEKLQSYEVNIEARDAG---TFSGKCTVLIQVIDVNDHAPEVTMSA 352
Query: 1154 FDELLEWKHPE--ADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFAN-DTDFIGNG 1210
F + PE S + +S + +I+E+ P A+ F T+ +
Sbjct: 353 FTSPIPENAPETVVALFSVSDLDSGENGKI-SCSIQEDLPFLLKSAENFYTLLTERPLDR 411
Query: 1211 NGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV 1270
Y++ +LG P L + + V +ADV D + P F Y L + EN
Sbjct: 412 ESRAEYNI--TITVTDLGTPMLITQLNMTVLIADVND-----NAPAFTQTSYTLFVRENN 464
Query: 1271 NAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREVK 1326
+ + + S++ T+ N ++ Y +L D + T + I+ NG L+ +RS D E
Sbjct: 465 SPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSLVSINADNGHLFALRSLDYEAL 524
Query: 1327 DTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTN 1382
++ V A H ++ + L V+VVV D NDNSP N
Sbjct: 525 QGFQFRVGAS--------DHGSPALSSEAL-------VRVVV--LDANDNSPFVLYPLQN 567
Query: 1383 GNRPLVTAIPTTAPFGYQVMQLKGAIG 1409
G+ P +P A GY V ++ G
Sbjct: 568 GSAPCTELVPRAAEPGYLVTKVVAVDG 594
Score = 106 bits (255), Expect = 5e-22
Identities = 122/471 (25%), Positives = 198/471 (42%), Gaps = 39/471 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E F E+ ++D ND++PVF+ + + ++ GT A D D+GQN +
Sbjct: 112 ESPFEFFQAELQVIDINDHSPVFLDKQML-VKVSESSPPGTTFPLKNAEDLDVGQNNIEN 170
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHA---LFVEASDQPANPSERRYSLA 553
Y + S + + + + V + + A L + A D + P R A
Sbjct: 171 YIISPNSYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTALDGGSPP---RSGTA 227
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLL 611
V IEV + P+F Y + + +G V ++ D ++SY L
Sbjct: 228 QVYIEVL----DVNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLF 283
Query: 612 HGYEE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
EE G F + +G I + L Y+ A ++ S + V+DVN
Sbjct: 284 QASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEA-RDAGTFSGKCTVLIQVIDVN 342
Query: 671 DERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D V + SPI EN+ + +F ++S + G + I Q+D+
Sbjct: 343 DHAPEVTMSAFTSPI----PENAPETVVA-LF--SVSDLDSGENGKISCSI--QEDLPFL 393
Query: 730 IAIAEDG-TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ AE+ T+ T++PLDRE R Y +T+ + G +T+ I D NDN P F
Sbjct: 394 LKSAENFYTLLTERPLDRESRAEYNITITVT-DLGTPMLITQLNMTVLIADVNDNAPAFT 452
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDEN 842
+Y F+ EN+ I+ + ATD D GTNA Y+L + ++ +
Sbjct: 453 QTSYTLFVRENNSPALHIRS---VSATDRDSGTNAQVTYSLLPPQDPHLPLTSLVSINAD 509
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
G + F SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 510 NGHL-FALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSP 559
Score = 85.4 bits (202), Expect = 1e-15
Identities = 71/245 (28%), Positives = 111/245 (45%), Gaps = 21/245 (8%)
Query: 911 NGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEF 970
+GTA IEV N A + +Q I E+ P+G ++K++A D+D+G+NG+I Y
Sbjct: 224 SGTAQ-VYIEVLDVNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISY-- 280
Query: 971 NSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDN 1028
L + E+ + F IN G + + + L E + +NI A D G +
Sbjct: 281 ---------SLFQASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGTFSGK 331
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
+V + V DVNDH P + + + E V+ +D D G+N ++ IQ
Sbjct: 332 CTVLIQVIDVNDHAPEVTMSAFTSPIPE-NAPETVVALFSVSDLDSGENGKISCSIQ--- 387
Query: 1089 TDLPFEISPLTGVLSVNGE--LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
DLPF + ++ E LDRE+ +Y +T+ D G DVND
Sbjct: 388 EDLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLG-TPMLITQLNMTVLIADVND 446
Query: 1147 NSPKF 1151
N+P F
Sbjct: 447 NAPAF 451
Score = 83.4 bits (197), Expect = 6e-15
Identities = 52/137 (37%), Positives = 78/137 (56%), Gaps = 11/137 (8%)
Query: 253 LFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN 312
L L+K LD + E L+ L + A +P ++ A+V IE+LD+NDN PEFE FY
Sbjct: 195 LVLDKALDREEEAELR-----LTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQPFYR 249
Query: 313 ISIVENLPNGFSVLQVMATDKDQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTV 368
+ I E+ P GF V++V ATD D G NGE +Y L ++ F I+P +G + ++ Q
Sbjct: 250 VQISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQASEEIGKTFKINPLTGEIELKKQ-- 307
Query: 369 LDREAHSSLRMKVYAKE 385
LD E S + + A++
Sbjct: 308 LDFEKLQSYEVNIEARD 324
Score = 83.0 bits (196), Expect = 7e-15
Identities = 71/239 (29%), Positives = 111/239 (46%), Gaps = 19/239 (7%)
Query: 662 ATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLI 720
A + V+D+ND V L ++ V E+S G F + G N+ ++I
Sbjct: 120 AELQVIDINDHSPVFLD---KQMLVKVSESSPP---GTTFPLKNAEDLDVGQNNIENYII 173
Query: 721 ANQQDVTDDIAIAEDGTIFTQ----KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIY 776
+ DG + + K LDRE+ R+T+ A + G +G QV I
Sbjct: 174 SPNSYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTA-LDGGSPPRSGTAQVYIE 232
Query: 777 IEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM 836
+ D NDN P FE Y I E+S +G + + ATD D G N Y+LF +E+
Sbjct: 233 VLDVNDNAPEFEQPFYRVQISEDSPVGFLVVK---VSATDVDTGVNGEISYSLFQASEEI 289
Query: 837 ---FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
F ++ TG ++ + LD EK Y++++ ARD G S + ++I + D ND+ PE
Sbjct: 290 GKTFKINPLTGEIE-LKKQLDFEKLQSYEVNIEARDAGTFSGKCTVLIQVIDVNDHAPE 347
Score = 72.1 bits (169), Expect = 1e-11
Identities = 70/237 (29%), Positives = 97/237 (40%), Gaps = 17/237 (7%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
+I+V N A +V IPEN P T + + DLDSG NG+I + +P
Sbjct: 335 LIQVIDVNDHAPEVTMSAFTSPIPENAP-ETVVALFSVSDLDSGENGKISCSIQED--LP 391
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVFVKD 1037
SA+ Y ++ ER + R E + ++ L L +++ V + D
Sbjct: 392 FLLKSAENF----YTLLTERP----LDRESRAEYNITITVTDLGTPMLITQLNMTVLIAD 443
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSDTDLPF--- 1093
VND+ P F +T Y V E + V ATD D G NA +TY + P D LP
Sbjct: 444 VNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSL 503
Query: 1094 -EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
I+ G L LD E + V A D+G D NDNSP
Sbjct: 504 VSINADNGHLFALRSLDYEALQGFQFRVGASDHG-SPALSSEALVRVVVLDANDNSP 559
Score = 63.3 bits (147), Expect = 6e-09
Identities = 82/328 (25%), Positives = 137/328 (41%), Gaps = 30/328 (9%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP------SLTIP 131
S +V + + DVND+ P + + + E P A +F ++ + S +I
Sbjct: 329 SGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENAPETVVA-LFSVSDLDSGENGKISCSIQ 387
Query: 132 LTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDY 190
+P L ++ ++P S Y+I ++ D G L + +L+ V D
Sbjct: 388 EDLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIADVNDN 447
Query: 191 DAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLFS 245
+ + + + L + A D+D G A + Y L+ D L S
Sbjct: 448 APAFTQTSYTLFV--RENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSLVS 505
Query: 246 LDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPE 305
+++ NG LF + LD +A LQ F +V AS +P +++A V + +LD NDN P
Sbjct: 506 INADNGHLFALRSLDYEA---LQG--FQFRVGASDHGSPALSSEALVRVVVLDANDNSPF 560
Query: 306 FEVDFYNIS--IVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPR 357
N S E +P G+ V +V+A D D G+N +YQL G F +
Sbjct: 561 VLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAH 620
Query: 358 SGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+G VR +L + R+ V K+
Sbjct: 621 NG--EVRTARLLSERDAAKHRLVVLVKD 646
Score = 57.6 bits (133), Expect = 3e-07
Identities = 60/201 (29%), Positives = 88/201 (43%), Gaps = 21/201 (10%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
LF+ N P I ++A D DSG N Q+ Y +PP L + IN
Sbjct: 458 LFVRENNSP-ALHIRSVSATDRDSGTNAQVTYSL-----LPPQD---PHLPLTSLVSINA 508
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+GH+ RSL E+ F+ + A D G+ L+ VRV V D ND+ P N
Sbjct: 509 DNGHLFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSPFVLYPLQNG 568
Query: 1053 NVEEAQYTRR------VLGKVDATDADFGQNANLTY-FIQPSDTDLPFEISPLTGVLSVN 1105
+ + R ++ KV A D D GQNA L+Y ++ ++ L F + G +
Sbjct: 569 SAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGL-FGVWAHNGEVRTA 627
Query: 1106 GELDRETEDKYILTVVARDNG 1126
L K+ L V+ +DNG
Sbjct: 628 RLLSERDAAKHRLVVLVKDNG 648
Score = 52.8 bits (121), Expect = 9e-06
Identities = 63/244 (25%), Positives = 105/244 (43%), Gaps = 21/244 (8%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
E + + LDRE + + F + S +Q + + D ND+ PVF
Sbjct: 81 ETADLLLNEKLDREDLCGHTEPCVLRFQVLLESPFEFFQAELQVIDINDHSPVFLDKQML 140
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----I 849
+ E+S GT + N A D D G N + Y + + + K+ +
Sbjct: 141 VKVSESSPPGTTFPLKN---AEDLDVGQNNIENYIISPNSYFRVLTRKRSDGRKYPELVL 197
Query: 850 GDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRE 907
+LDRE++ +L+L A D G S A++ I + D NDN PEF Q +V+I +
Sbjct: 198 DKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQ--PFYRVQISED 255
Query: 908 TKLNGTAGFTIIEVKPKNKFALDVDQLGPL--FLIPENIPIGTTIIKLNALDLDSGLNGQ 965
+ + GF +++V + +D G + L + IG T K+N L + L Q
Sbjct: 256 SPV----GFLVVKVSATD---VDTGVNGEISYSLFQASEEIGKT-FKINPLTGEIELKKQ 307
Query: 966 IRYE 969
+ +E
Sbjct: 308 LDFE 311
Score = 46.4 bits (105), Expect = 8e-04
Identities = 38/121 (31%), Positives = 48/121 (39%), Gaps = 5/121 (4%)
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFE 1094
V D+NDH PVF V E+ +A D D GQN Y I P+
Sbjct: 124 VIDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENYIISPNSYFRVLT 183
Query: 1095 ISPLTG----VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
G L ++ LDRE E + LT+ A D G DVNDN+P+
Sbjct: 184 RKRSDGRKYPELVLDKALDREEEAELRLTLTALDGG-SPPRSGTAQVYIEVLDVNDNAPE 242
Query: 1151 F 1151
F
Sbjct: 243 F 243
Score = 42.7 bits (96), Expect = 0.010
Identities = 39/126 (30%), Positives = 55/126 (43%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 541 LSSEALVRVVVLDANDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 599
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + L + + N T + S +H L V D P +L
Sbjct: 600 AWLSYQLLKATELGLFGVWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 658
Query: 553 AVVTIE 558
V+ ++
Sbjct: 659 HVLLVD 664
Score = 35.1 bits (77), Expect = 2.0
Identities = 38/154 (24%), Positives = 67/154 (43%), Gaps = 10/154 (6%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
++S ++ L+ L L ++LD + VL+ Q L +P + QA E+
Sbjct: 67 VVSRGNKLHLQLNQETADLLLNEKLDREDLCG-HTEPCVLRFQVL-LESPFEFFQA--EL 122
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
+++D+ND+ P F + + E+ P G + A D D G+N Y + P F +
Sbjct: 123 QVIDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENY-IISPNSYFRV 181
Query: 355 DPRS-----GWLTVRNQTVLDREAHSSLRMKVYA 383
R + + LDRE + LR+ + A
Sbjct: 182 LTRKRSDGRKYPELVLDKALDREEEAELRLTLTA 215
Score = 33.5 bits (73), Expect = 6.0
Identities = 16/36 (44%), Positives = 20/36 (55%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE 108
G + L++TV I DVNDN P F T Y + V E
Sbjct: 427 GTPMLITQLNMTVLIADVNDNAPAFTQTSYTLFVRE 462
>BC033068-1|AAH33068.1| 798|Homo sapiens protocadherin beta 13
protein.
Length = 798
Score = 109 bits (262), Expect = 7e-23
Identities = 136/507 (26%), Positives = 224/507 (44%), Gaps = 63/507 (12%)
Query: 929 LDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
+D++ P+FL + E+ P GTT NA DLD G N N E YI
Sbjct: 125 IDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQN-------NIENYIISPNS 177
Query: 982 SADALEVKRYFVINERHGHVIVARSLP--PESEFRLNISALDGGNLNDNISVRVFVK--D 1037
L KR ++ +++ ++L E+E RL ++ALDGG+ + + +V+++ D
Sbjct: 178 YFRVLTRKRSD--GRKYPELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLD 235
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDL--PFEI 1095
VND+ P F++ +Y + E ++ KV ATD D G N ++Y + + ++ F+I
Sbjct: 236 VNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQASEEIGKTFKI 295
Query: 1096 SPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK--FYA 1153
+PLTG + + +LD E Y + + ARD G DVND++P+ A
Sbjct: 296 NPLTGEIELKKQLDFEKLQSYEVNIEARDAG---TFSGKCTVLIQVIDVNDHAPEVTMSA 352
Query: 1154 FDELLEWKHPE--ADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFAN-DTDFIGNG 1210
F + PE S + +S + +I+E+ P A+ F T+ +
Sbjct: 353 FTSPIPENAPETVVALFSVSDLDSGENGKI-SCSIQEDLPFLLKSAENFYTLLTERPLDR 411
Query: 1211 NGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV 1270
Y++ +LG P L + + V +ADV D + P F Y L + EN
Sbjct: 412 ESRAEYNI--TITVTDLGTPMLITQLNMTVLIADVND-----NAPAFTQTSYTLFVRENN 464
Query: 1271 NAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREVK 1326
+ + + S++ T+ N ++ Y +L D + T + I+ NG L+ +RS D E
Sbjct: 465 SPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSLVSINADNGHLFALRSLDYEAL 524
Query: 1327 DTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTN 1382
++ V A H ++ + L V+VVV D NDNSP N
Sbjct: 525 QGFQFRVGAS--------DHGSPALSSEAL-------VRVVV--LDANDNSPFVLYPLQN 567
Query: 1383 GNRPLVTAIPTTAPFGYQVMQLKGAIG 1409
G+ P +P A GY V ++ G
Sbjct: 568 GSAPCTELVPRAAEPGYLVTKVVAVDG 594
Score = 106 bits (255), Expect = 5e-22
Identities = 122/471 (25%), Positives = 198/471 (42%), Gaps = 39/471 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E F E+ ++D ND++PVF+ + + ++ GT A D D+GQN +
Sbjct: 112 ESPFEFFQAELQVIDINDHSPVFLDKQML-VKVSESSPPGTTFPLKNAEDLDVGQNNIEN 170
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHA---LFVEASDQPANPSERRYSLA 553
Y + S + + + + V + + A L + A D + P R A
Sbjct: 171 YIISPNSYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTALDGGSPP---RSGTA 227
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLL 611
V IEV + P+F Y + + +G V ++ D ++SY L
Sbjct: 228 QVYIEVL----DVNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLF 283
Query: 612 HGYEE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
EE G F + +G I + L Y+ A ++ S + V+DVN
Sbjct: 284 QASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEA-RDAGTFSGKCTVLIQVIDVN 342
Query: 671 DERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D V + SPI EN+ + +F ++S + G + I Q+D+
Sbjct: 343 DHAPEVTMSAFTSPI----PENAPETVVA-LF--SVSDLDSGENGKISCSI--QEDLPFL 393
Query: 730 IAIAEDG-TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ AE+ T+ T++PLDRE R Y +T+ + G +T+ I D NDN P F
Sbjct: 394 LKSAENFYTLLTERPLDRESRAEYNITITVT-DLGTPMLITQLNMTVLIADVNDNAPAFT 452
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDEN 842
+Y F+ EN+ I+ + ATD D GTNA Y+L + ++ +
Sbjct: 453 QTSYTLFVRENNSPALHIRS---VSATDRDSGTNAQVTYSLLPPQDPHLPLTSLVSINAD 509
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
G + F SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 510 NGHL-FALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSP 559
Score = 85.4 bits (202), Expect = 1e-15
Identities = 71/245 (28%), Positives = 111/245 (45%), Gaps = 21/245 (8%)
Query: 911 NGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEF 970
+GTA IEV N A + +Q I E+ P+G ++K++A D+D+G+NG+I Y
Sbjct: 224 SGTAQ-VYIEVLDVNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISY-- 280
Query: 971 NSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDN 1028
L + E+ + F IN G + + + L E + +NI A D G +
Sbjct: 281 ---------SLFQASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGTFSGK 331
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
+V + V DVNDH P + + + E V+ +D D G+N ++ IQ
Sbjct: 332 CTVLIQVIDVNDHAPEVTMSAFTSPIPE-NAPETVVALFSVSDLDSGENGKISCSIQ--- 387
Query: 1089 TDLPFEISPLTGVLSVNGE--LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
DLPF + ++ E LDRE+ +Y +T+ D G DVND
Sbjct: 388 EDLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLG-TPMLITQLNMTVLIADVND 446
Query: 1147 NSPKF 1151
N+P F
Sbjct: 447 NAPAF 451
Score = 83.4 bits (197), Expect = 6e-15
Identities = 52/137 (37%), Positives = 78/137 (56%), Gaps = 11/137 (8%)
Query: 253 LFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN 312
L L+K LD + E L+ L + A +P ++ A+V IE+LD+NDN PEFE FY
Sbjct: 195 LVLDKALDREEEAELR-----LTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQPFYR 249
Query: 313 ISIVENLPNGFSVLQVMATDKDQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTV 368
+ I E+ P GF V++V ATD D G NGE +Y L ++ F I+P +G + ++ Q
Sbjct: 250 VQISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQASEEIGKTFKINPLTGEIELKKQ-- 307
Query: 369 LDREAHSSLRMKVYAKE 385
LD E S + + A++
Sbjct: 308 LDFEKLQSYEVNIEARD 324
Score = 83.0 bits (196), Expect = 7e-15
Identities = 71/239 (29%), Positives = 111/239 (46%), Gaps = 19/239 (7%)
Query: 662 ATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLI 720
A + V+D+ND V L ++ V E+S G F + G N+ ++I
Sbjct: 120 AELQVIDINDHSPVFLD---KQMLVKVSESSPP---GTTFPLKNAEDLDVGQNNIENYII 173
Query: 721 ANQQDVTDDIAIAEDGTIFTQ----KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIY 776
+ DG + + K LDRE+ R+T+ A + G +G QV I
Sbjct: 174 SPNSYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTA-LDGGSPPRSGTAQVYIE 232
Query: 777 IEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM 836
+ D NDN P FE Y I E+S +G + + ATD D G N Y+LF +E+
Sbjct: 233 VLDVNDNAPEFEQPFYRVQISEDSPVGFLVVK---VSATDVDTGVNGEISYSLFQASEEI 289
Query: 837 ---FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
F ++ TG ++ + LD EK Y++++ ARD G S + ++I + D ND+ PE
Sbjct: 290 GKTFKINPLTGEIE-LKKQLDFEKLQSYEVNIEARDAGTFSGKCTVLIQVIDVNDHAPE 347
Score = 72.1 bits (169), Expect = 1e-11
Identities = 70/237 (29%), Positives = 97/237 (40%), Gaps = 17/237 (7%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
+I+V N A +V IPEN P T + + DLDSG NG+I + +P
Sbjct: 335 LIQVIDVNDHAPEVTMSAFTSPIPENAP-ETVVALFSVSDLDSGENGKISCSIQED--LP 391
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVFVKD 1037
SA+ Y ++ ER + R E + ++ L L +++ V + D
Sbjct: 392 FLLKSAENF----YTLLTERP----LDRESRAEYNITITVTDLGTPMLITQLNMTVLIAD 443
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSDTDLPF--- 1093
VND+ P F +T Y V E + V ATD D G NA +TY + P D LP
Sbjct: 444 VNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSL 503
Query: 1094 -EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
I+ G L LD E + V A D+G D NDNSP
Sbjct: 504 VSINADNGHLFALRSLDYEALQGFQFRVGASDHG-SPALSSEALVRVVVLDANDNSP 559
Score = 63.3 bits (147), Expect = 6e-09
Identities = 82/328 (25%), Positives = 137/328 (41%), Gaps = 30/328 (9%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP------SLTIP 131
S +V + + DVND+ P + + + E P A +F ++ + S +I
Sbjct: 329 SGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENAPETVVA-LFSVSDLDSGENGKISCSIQ 387
Query: 132 LTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDY 190
+P L ++ ++P S Y+I ++ D G L + +L+ V D
Sbjct: 388 EDLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIADVNDN 447
Query: 191 DAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLFS 245
+ + + + L + A D+D G A + Y L+ D L S
Sbjct: 448 APAFTQTSYTLFV--RENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSLVS 505
Query: 246 LDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPE 305
+++ NG LF + LD +A LQ F +V AS +P +++A V + +LD NDN P
Sbjct: 506 INADNGHLFALRSLDYEA---LQG--FQFRVGASDHGSPALSSEALVRVVVLDANDNSPF 560
Query: 306 FEVDFYNIS--IVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPR 357
N S E +P G+ V +V+A D D G+N +YQL G F +
Sbjct: 561 VLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAH 620
Query: 358 SGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+G VR +L + R+ V K+
Sbjct: 621 NG--EVRTARLLSERDAAKHRLVVLVKD 646
Score = 57.6 bits (133), Expect = 3e-07
Identities = 60/201 (29%), Positives = 88/201 (43%), Gaps = 21/201 (10%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
LF+ N P I ++A D DSG N Q+ Y +PP L + IN
Sbjct: 458 LFVRENNSP-ALHIRSVSATDRDSGTNAQVTYSL-----LPPQD---PHLPLTSLVSINA 508
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+GH+ RSL E+ F+ + A D G+ L+ VRV V D ND+ P N
Sbjct: 509 DNGHLFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSPFVLYPLQNG 568
Query: 1053 NVEEAQYTRR------VLGKVDATDADFGQNANLTY-FIQPSDTDLPFEISPLTGVLSVN 1105
+ + R ++ KV A D D GQNA L+Y ++ ++ L F + G +
Sbjct: 569 SAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGL-FGVWAHNGEVRTA 627
Query: 1106 GELDRETEDKYILTVVARDNG 1126
L K+ L V+ +DNG
Sbjct: 628 RLLSERDAAKHRLVVLVKDNG 648
Score = 52.8 bits (121), Expect = 9e-06
Identities = 63/244 (25%), Positives = 105/244 (43%), Gaps = 21/244 (8%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
E + + LDRE + + F + S +Q + + D ND+ PVF
Sbjct: 81 ETADLLLNEKLDREDLCGHTEPCVLRFQVLLESPFEFFQAELQVIDINDHSPVFLDKQML 140
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----I 849
+ E+S GT + N A D D G N + Y + + + K+ +
Sbjct: 141 VKVSESSPPGTTFPLKN---AEDLDVGQNNIENYIISPNSYFRVLTRKRSDGRKYPELVL 197
Query: 850 GDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRE 907
+LDRE++ +L+L A D G S A++ I + D NDN PEF Q +V+I +
Sbjct: 198 DKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQ--PFYRVQISED 255
Query: 908 TKLNGTAGFTIIEVKPKNKFALDVDQLGPL--FLIPENIPIGTTIIKLNALDLDSGLNGQ 965
+ + GF +++V + +D G + L + IG T K+N L + L Q
Sbjct: 256 SPV----GFLVVKVSATD---VDTGVNGEISYSLFQASEEIGKT-FKINPLTGEIELKKQ 307
Query: 966 IRYE 969
+ +E
Sbjct: 308 LDFE 311
Score = 46.4 bits (105), Expect = 8e-04
Identities = 38/121 (31%), Positives = 48/121 (39%), Gaps = 5/121 (4%)
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFE 1094
V D+NDH PVF V E+ +A D D GQN Y I P+
Sbjct: 124 VIDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENYIISPNSYFRVLT 183
Query: 1095 ISPLTG----VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
G L ++ LDRE E + LT+ A D G DVNDN+P+
Sbjct: 184 RKRSDGRKYPELVLDKALDREEEAELRLTLTALDGG-SPPRSGTAQVYIEVLDVNDNAPE 242
Query: 1151 F 1151
F
Sbjct: 243 F 243
Score = 42.7 bits (96), Expect = 0.010
Identities = 39/126 (30%), Positives = 55/126 (43%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 541 LSSEALVRVVVLDANDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 599
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + L + + N T + S +H L V D P +L
Sbjct: 600 AWLSYQLLKATELGLFGVWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 658
Query: 553 AVVTIE 558
V+ ++
Sbjct: 659 HVLLVD 664
Score = 35.1 bits (77), Expect = 2.0
Identities = 38/154 (24%), Positives = 67/154 (43%), Gaps = 10/154 (6%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
++S ++ L+ L L ++LD + VL+ Q L +P + QA E+
Sbjct: 67 VVSRGNKLHLQLNQETADLLLNEKLDREDLCG-HTEPCVLRFQVL-LESPFEFFQA--EL 122
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
+++D+ND+ P F + + E+ P G + A D D G+N Y + P F +
Sbjct: 123 QVIDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENY-IISPNSYFRV 181
Query: 355 DPRS-----GWLTVRNQTVLDREAHSSLRMKVYA 383
R + + LDRE + LR+ + A
Sbjct: 182 LTRKRSDGRKYPELVLDKALDREEEAELRLTLTA 215
Score = 33.5 bits (73), Expect = 6.0
Identities = 16/36 (44%), Positives = 20/36 (55%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE 108
G + L++TV I DVNDN P F T Y + V E
Sbjct: 427 GTPMLITQLNMTVLIADVNDNAPAFTQTSYTLFVRE 462
>AY358427-1|AAQ88793.1| 798|Homo sapiens PCDHB13 protein.
Length = 798
Score = 109 bits (262), Expect = 7e-23
Identities = 136/507 (26%), Positives = 224/507 (44%), Gaps = 63/507 (12%)
Query: 929 LDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
+D++ P+FL + E+ P GTT NA DLD G N N E YI
Sbjct: 125 IDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQN-------NIENYIISPNS 177
Query: 982 SADALEVKRYFVINERHGHVIVARSLP--PESEFRLNISALDGGNLNDNISVRVFVK--D 1037
L KR ++ +++ ++L E+E RL ++ALDGG+ + + +V+++ D
Sbjct: 178 YFRVLTRKRSD--GRKYPELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLD 235
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDL--PFEI 1095
VND+ P F++ +Y + E ++ KV ATD D G N ++Y + + ++ F+I
Sbjct: 236 VNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQASEEIGKTFKI 295
Query: 1096 SPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK--FYA 1153
+PLTG + + +LD E Y + + ARD G DVND++P+ A
Sbjct: 296 NPLTGEIELKKQLDFEKLQSYEVNIEARDAG---TFSGKCTVLIQVIDVNDHAPEVTMSA 352
Query: 1154 FDELLEWKHPE--ADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFAN-DTDFIGNG 1210
F + PE S + +S + +I+E+ P A+ F T+ +
Sbjct: 353 FTSPIPENAPETVVALFSVSDLDSGENGKI-SCSIQEDLPFLLKSAENFYTLLTERPLDR 411
Query: 1211 NGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV 1270
Y++ +LG P L + + V +ADV D + P F Y L + EN
Sbjct: 412 ESRAEYNI--TITVTDLGTPMLITQLNMTVLIADVND-----NAPAFTQTSYTLFVRENN 464
Query: 1271 NAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREVK 1326
+ + + S++ T+ N ++ Y +L D + T + I+ NG L+ +RS D E
Sbjct: 465 SPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSLVSINADNGHLFALRSLDYEAL 524
Query: 1327 DTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTN 1382
++ V A H ++ + L V+VVV D NDNSP N
Sbjct: 525 QGFQFRVGAS--------DHGSPALSSEAL-------VRVVV--LDANDNSPFVLYPLQN 567
Query: 1383 GNRPLVTAIPTTAPFGYQVMQLKGAIG 1409
G+ P +P A GY V ++ G
Sbjct: 568 GSAPCTELVPRAAEPGYLVTKVVAVDG 594
Score = 106 bits (255), Expect = 5e-22
Identities = 122/471 (25%), Positives = 198/471 (42%), Gaps = 39/471 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E F E+ ++D ND++PVF+ + + ++ GT A D D+GQN +
Sbjct: 112 ESPFEFFQAELQVIDINDHSPVFLDKQML-VKVSESSPPGTTFPLKNAEDLDVGQNNIEN 170
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHA---LFVEASDQPANPSERRYSLA 553
Y + S + + + + V + + A L + A D + P R A
Sbjct: 171 YIISPNSYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTALDGGSPP---RSGTA 227
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLL 611
V IEV + P+F Y + + +G V ++ D ++SY L
Sbjct: 228 QVYIEVL----DVNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLF 283
Query: 612 HGYEE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
EE G F + +G I + L Y+ A ++ S + V+DVN
Sbjct: 284 QASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEA-RDAGTFSGKCTVLIQVIDVN 342
Query: 671 DERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D V + SPI EN+ + +F ++S + G + I Q+D+
Sbjct: 343 DHAPEVTMSAFTSPI----PENAPETVVA-LF--SVSDLDSGENGKISCSI--QEDLPFL 393
Query: 730 IAIAEDG-TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ AE+ T+ T++PLDRE R Y +T+ + G +T+ I D NDN P F
Sbjct: 394 LKSAENFYTLLTERPLDRESRAEYNITITVT-DLGTPMLITQLNMTVLIADVNDNAPAFT 452
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDEN 842
+Y F+ EN+ I+ + ATD D GTNA Y+L + ++ +
Sbjct: 453 QTSYTLFVRENNSPALHIRS---VSATDRDSGTNAQVTYSLLPPQDPHLPLTSLVSINAD 509
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
G + F SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 510 NGHL-FALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSP 559
Score = 85.4 bits (202), Expect = 1e-15
Identities = 71/245 (28%), Positives = 111/245 (45%), Gaps = 21/245 (8%)
Query: 911 NGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEF 970
+GTA IEV N A + +Q I E+ P+G ++K++A D+D+G+NG+I Y
Sbjct: 224 SGTAQ-VYIEVLDVNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISY-- 280
Query: 971 NSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDN 1028
L + E+ + F IN G + + + L E + +NI A D G +
Sbjct: 281 ---------SLFQASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGTFSGK 331
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
+V + V DVNDH P + + + E V+ +D D G+N ++ IQ
Sbjct: 332 CTVLIQVIDVNDHAPEVTMSAFTSPIPE-NAPETVVALFSVSDLDSGENGKISCSIQ--- 387
Query: 1089 TDLPFEISPLTGVLSVNGE--LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
DLPF + ++ E LDRE+ +Y +T+ D G DVND
Sbjct: 388 EDLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLG-TPMLITQLNMTVLIADVND 446
Query: 1147 NSPKF 1151
N+P F
Sbjct: 447 NAPAF 451
Score = 83.4 bits (197), Expect = 6e-15
Identities = 52/137 (37%), Positives = 78/137 (56%), Gaps = 11/137 (8%)
Query: 253 LFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN 312
L L+K LD + E L+ L + A +P ++ A+V IE+LD+NDN PEFE FY
Sbjct: 195 LVLDKALDREEEAELR-----LTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQPFYR 249
Query: 313 ISIVENLPNGFSVLQVMATDKDQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTV 368
+ I E+ P GF V++V ATD D G NGE +Y L ++ F I+P +G + ++ Q
Sbjct: 250 VQISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQASEEIGKTFKINPLTGEIELKKQ-- 307
Query: 369 LDREAHSSLRMKVYAKE 385
LD E S + + A++
Sbjct: 308 LDFEKLQSYEVNIEARD 324
Score = 83.0 bits (196), Expect = 7e-15
Identities = 71/239 (29%), Positives = 111/239 (46%), Gaps = 19/239 (7%)
Query: 662 ATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLI 720
A + V+D+ND V L ++ V E+S G F + G N+ ++I
Sbjct: 120 AELQVIDINDHSPVFLD---KQMLVKVSESSPP---GTTFPLKNAEDLDVGQNNIENYII 173
Query: 721 ANQQDVTDDIAIAEDGTIFTQ----KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIY 776
+ DG + + K LDRE+ R+T+ A + G +G QV I
Sbjct: 174 SPNSYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTA-LDGGSPPRSGTAQVYIE 232
Query: 777 IEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM 836
+ D NDN P FE Y I E+S +G + + ATD D G N Y+LF +E+
Sbjct: 233 VLDVNDNAPEFEQPFYRVQISEDSPVGFLVVK---VSATDVDTGVNGEISYSLFQASEEI 289
Query: 837 ---FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
F ++ TG ++ + LD EK Y++++ ARD G S + ++I + D ND+ PE
Sbjct: 290 GKTFKINPLTGEIE-LKKQLDFEKLQSYEVNIEARDAGTFSGKCTVLIQVIDVNDHAPE 347
Score = 72.1 bits (169), Expect = 1e-11
Identities = 70/237 (29%), Positives = 97/237 (40%), Gaps = 17/237 (7%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
+I+V N A +V IPEN P T + + DLDSG NG+I + +P
Sbjct: 335 LIQVIDVNDHAPEVTMSAFTSPIPENAP-ETVVALFSVSDLDSGENGKISCSIQED--LP 391
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVFVKD 1037
SA+ Y ++ ER + R E + ++ L L +++ V + D
Sbjct: 392 FLLKSAENF----YTLLTERP----LDRESRAEYNITITVTDLGTPMLITQLNMTVLIAD 443
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSDTDLPF--- 1093
VND+ P F +T Y V E + V ATD D G NA +TY + P D LP
Sbjct: 444 VNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSL 503
Query: 1094 -EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
I+ G L LD E + V A D+G D NDNSP
Sbjct: 504 VSINADNGHLFALRSLDYEALQGFQFRVGASDHG-SPALSSEALVRVVVLDANDNSP 559
Score = 63.3 bits (147), Expect = 6e-09
Identities = 82/328 (25%), Positives = 137/328 (41%), Gaps = 30/328 (9%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP------SLTIP 131
S +V + + DVND+ P + + + E P A +F ++ + S +I
Sbjct: 329 SGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENAPETVVA-LFSVSDLDSGENGKISCSIQ 387
Query: 132 LTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDY 190
+P L ++ ++P S Y+I ++ D G L + +L+ V D
Sbjct: 388 EDLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIADVNDN 447
Query: 191 DAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLFS 245
+ + + + L + A D+D G A + Y L+ D L S
Sbjct: 448 APAFTQTSYTLFV--RENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSLVS 505
Query: 246 LDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPE 305
+++ NG LF + LD +A LQ F +V AS +P +++A V + +LD NDN P
Sbjct: 506 INADNGHLFALRSLDYEA---LQG--FQFRVGASDHGSPALSSEALVRVVVLDANDNSPF 560
Query: 306 FEVDFYNIS--IVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPR 357
N S E +P G+ V +V+A D D G+N +YQL G F +
Sbjct: 561 VLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAH 620
Query: 358 SGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+G VR +L + R+ V K+
Sbjct: 621 NG--EVRTARLLSERDAAKHRLVVLVKD 646
Score = 57.6 bits (133), Expect = 3e-07
Identities = 60/201 (29%), Positives = 88/201 (43%), Gaps = 21/201 (10%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
LF+ N P I ++A D DSG N Q+ Y +PP L + IN
Sbjct: 458 LFVRENNSP-ALHIRSVSATDRDSGTNAQVTYSL-----LPPQD---PHLPLTSLVSINA 508
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+GH+ RSL E+ F+ + A D G+ L+ VRV V D ND+ P N
Sbjct: 509 DNGHLFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSPFVLYPLQNG 568
Query: 1053 NVEEAQYTRR------VLGKVDATDADFGQNANLTY-FIQPSDTDLPFEISPLTGVLSVN 1105
+ + R ++ KV A D D GQNA L+Y ++ ++ L F + G +
Sbjct: 569 SAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGL-FGVWAHNGEVRTA 627
Query: 1106 GELDRETEDKYILTVVARDNG 1126
L K+ L V+ +DNG
Sbjct: 628 RLLSERDAAKHRLVVLVKDNG 648
Score = 52.8 bits (121), Expect = 9e-06
Identities = 63/244 (25%), Positives = 105/244 (43%), Gaps = 21/244 (8%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
E + + LDRE + + F + S +Q + + D ND+ PVF
Sbjct: 81 ETADLLLNEKLDREDLCGHTEPCVLRFQVLLESPFEFFQAELQVIDINDHSPVFLDKQML 140
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----I 849
+ E+S GT + N A D D G N + Y + + + K+ +
Sbjct: 141 VKVSESSPPGTTFPLKN---AEDLDVGQNNIENYIISPNSYFRVLTRKRSDGRKYPELVL 197
Query: 850 GDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRE 907
+LDRE++ +L+L A D G S A++ I + D NDN PEF Q +V+I +
Sbjct: 198 DKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQ--PFYRVQISED 255
Query: 908 TKLNGTAGFTIIEVKPKNKFALDVDQLGPL--FLIPENIPIGTTIIKLNALDLDSGLNGQ 965
+ + GF +++V + +D G + L + IG T K+N L + L Q
Sbjct: 256 SPV----GFLVVKVSATD---VDTGVNGEISYSLFQASEEIGKT-FKINPLTGEIELKKQ 307
Query: 966 IRYE 969
+ +E
Sbjct: 308 LDFE 311
Score = 46.4 bits (105), Expect = 8e-04
Identities = 38/121 (31%), Positives = 48/121 (39%), Gaps = 5/121 (4%)
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFE 1094
V D+NDH PVF V E+ +A D D GQN Y I P+
Sbjct: 124 VIDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENYIISPNSYFRVLT 183
Query: 1095 ISPLTG----VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
G L ++ LDRE E + LT+ A D G DVNDN+P+
Sbjct: 184 RKRSDGRKYPELVLDKALDREEEAELRLTLTALDGG-SPPRSGTAQVYIEVLDVNDNAPE 242
Query: 1151 F 1151
F
Sbjct: 243 F 243
Score = 42.7 bits (96), Expect = 0.010
Identities = 39/126 (30%), Positives = 55/126 (43%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 541 LSSEALVRVVVLDANDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 599
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + L + + N T + S +H L V D P +L
Sbjct: 600 AWLSYQLLKATELGLFGVWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 658
Query: 553 AVVTIE 558
V+ ++
Sbjct: 659 HVLLVD 664
Score = 35.1 bits (77), Expect = 2.0
Identities = 38/154 (24%), Positives = 67/154 (43%), Gaps = 10/154 (6%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
++S ++ L+ L L ++LD + VL+ Q L +P + QA E+
Sbjct: 67 VVSRGNKLHLQLNQETADLLLNEKLDREDLCG-HTEPCVLRFQVL-LESPFEFFQA--EL 122
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
+++D+ND+ P F + + E+ P G + A D D G+N Y + P F +
Sbjct: 123 QVIDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENY-IISPNSYFRV 181
Query: 355 DPRS-----GWLTVRNQTVLDREAHSSLRMKVYA 383
R + + LDRE + LR+ + A
Sbjct: 182 LTRKRSDGRKYPELVLDKALDREEEAELRLTLTA 215
Score = 33.5 bits (73), Expect = 6.0
Identities = 16/36 (44%), Positives = 20/36 (55%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE 108
G + L++TV I DVNDN P F T Y + V E
Sbjct: 427 GTPMLITQLNMTVLIADVNDNAPAFTQTSYTLFVRE 462
>AF217745-1|AAK51613.1| 798|Homo sapiens protocadherin-beta13
protein.
Length = 798
Score = 109 bits (262), Expect = 7e-23
Identities = 136/507 (26%), Positives = 224/507 (44%), Gaps = 63/507 (12%)
Query: 929 LDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
+D++ P+FL + E+ P GTT NA DLD G N N E YI
Sbjct: 125 IDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQN-------NIENYIISPNS 177
Query: 982 SADALEVKRYFVINERHGHVIVARSLP--PESEFRLNISALDGGNLNDNISVRVFVK--D 1037
L KR ++ +++ ++L E+E RL ++ALDGG+ + + +V+++ D
Sbjct: 178 YFRVLTRKRSD--GRKYPELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLD 235
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDL--PFEI 1095
VND+ P F++ +Y + E ++ KV ATD D G N ++Y + + ++ F+I
Sbjct: 236 VNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQASEEIGKTFKI 295
Query: 1096 SPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK--FYA 1153
+PLTG + + +LD E Y + + ARD G DVND++P+ A
Sbjct: 296 NPLTGEIELKKQLDFEKLQSYEVNIEARDAG---TFSGKCTVLIQVIDVNDHAPEVTMSA 352
Query: 1154 FDELLEWKHPE--ADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFAN-DTDFIGNG 1210
F + PE S + +S + +I+E+ P A+ F T+ +
Sbjct: 353 FTSPIPENAPETVVALFSVSDLDSGENGKI-SCSIQEDLPFLLKSAENFYTLLTERPLDR 411
Query: 1211 NGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV 1270
Y++ +LG P L + + V +ADV D + P F Y L + EN
Sbjct: 412 ESRAEYNI--TITVTDLGTPMLITQLNMTVLIADVND-----NAPAFTQTSYTLFVRENN 464
Query: 1271 NAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREVK 1326
+ + + S++ T+ N ++ Y +L D + T + I+ NG L+ +RS D E
Sbjct: 465 SPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSLVSINADNGHLFALRSLDYEAL 524
Query: 1327 DTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTN 1382
++ V A H ++ + L V+VVV D NDNSP N
Sbjct: 525 QGFQFRVGAS--------DHGSPALSSEAL-------VRVVV--LDANDNSPFVLYPLQN 567
Query: 1383 GNRPLVTAIPTTAPFGYQVMQLKGAIG 1409
G+ P +P A GY V ++ G
Sbjct: 568 GSAPCTELVPRAAEPGYLVTKVVAVDG 594
Score = 106 bits (255), Expect = 5e-22
Identities = 122/471 (25%), Positives = 198/471 (42%), Gaps = 39/471 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E F E+ ++D ND++PVF+ + + ++ GT A D D+GQN +
Sbjct: 112 ESPFEFFQAELQVIDINDHSPVFLDKQML-VKVSESSPPGTTFPLKNAEDLDVGQNNIEN 170
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHA---LFVEASDQPANPSERRYSLA 553
Y + S + + + + V + + A L + A D + P R A
Sbjct: 171 YIISPNSYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTALDGGSPP---RSGTA 227
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLL 611
V IEV + P+F Y + + +G V ++ D ++SY L
Sbjct: 228 QVYIEVL----DVNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLF 283
Query: 612 HGYEE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
EE G F + +G I + L Y+ A ++ S + V+DVN
Sbjct: 284 QASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEA-RDAGTFSGKCTVLIQVIDVN 342
Query: 671 DERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D V + SPI EN+ + +F ++S + G + I Q+D+
Sbjct: 343 DHAPEVTMSAFTSPI----PENAPETVVA-LF--SVSDLDSGENGKISCSI--QEDLPFL 393
Query: 730 IAIAEDG-TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ AE+ T+ T++PLDRE R Y +T+ + G +T+ I D NDN P F
Sbjct: 394 LKSAENFYTLLTERPLDRESRAEYNITITVT-DLGTPMLITQLNMTVLIADVNDNAPAFT 452
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDEN 842
+Y F+ EN+ I+ + ATD D GTNA Y+L + ++ +
Sbjct: 453 QTSYTLFVRENNSPALHIRS---VSATDRDSGTNAQVTYSLLPPQDPHLPLTSLVSINAD 509
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
G + F SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 510 NGHL-FALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSP 559
Score = 85.4 bits (202), Expect = 1e-15
Identities = 71/245 (28%), Positives = 111/245 (45%), Gaps = 21/245 (8%)
Query: 911 NGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEF 970
+GTA IEV N A + +Q I E+ P+G ++K++A D+D+G+NG+I Y
Sbjct: 224 SGTAQ-VYIEVLDVNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISY-- 280
Query: 971 NSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDN 1028
L + E+ + F IN G + + + L E + +NI A D G +
Sbjct: 281 ---------SLFQASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGTFSGK 331
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
+V + V DVNDH P + + + E V+ +D D G+N ++ IQ
Sbjct: 332 CTVLIQVIDVNDHAPEVTMSAFTSPIPE-NAPETVVALFSVSDLDSGENGKISCSIQ--- 387
Query: 1089 TDLPFEISPLTGVLSVNGE--LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
DLPF + ++ E LDRE+ +Y +T+ D G DVND
Sbjct: 388 EDLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLG-TPMLITQLNMTVLIADVND 446
Query: 1147 NSPKF 1151
N+P F
Sbjct: 447 NAPAF 451
Score = 83.4 bits (197), Expect = 6e-15
Identities = 52/137 (37%), Positives = 78/137 (56%), Gaps = 11/137 (8%)
Query: 253 LFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN 312
L L+K LD + E L+ L + A +P ++ A+V IE+LD+NDN PEFE FY
Sbjct: 195 LVLDKALDREEEAELR-----LTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQPFYR 249
Query: 313 ISIVENLPNGFSVLQVMATDKDQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTV 368
+ I E+ P GF V++V ATD D G NGE +Y L ++ F I+P +G + ++ Q
Sbjct: 250 VQISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQASEEIGKTFKINPLTGEIELKKQ-- 307
Query: 369 LDREAHSSLRMKVYAKE 385
LD E S + + A++
Sbjct: 308 LDFEKLQSYEVNIEARD 324
Score = 83.0 bits (196), Expect = 7e-15
Identities = 71/239 (29%), Positives = 111/239 (46%), Gaps = 19/239 (7%)
Query: 662 ATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLI 720
A + V+D+ND V L ++ V E+S G F + G N+ ++I
Sbjct: 120 AELQVIDINDHSPVFLD---KQMLVKVSESSPP---GTTFPLKNAEDLDVGQNNIENYII 173
Query: 721 ANQQDVTDDIAIAEDGTIFTQ----KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIY 776
+ DG + + K LDRE+ R+T+ A + G +G QV I
Sbjct: 174 SPNSYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTA-LDGGSPPRSGTAQVYIE 232
Query: 777 IEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM 836
+ D NDN P FE Y I E+S +G + + ATD D G N Y+LF +E+
Sbjct: 233 VLDVNDNAPEFEQPFYRVQISEDSPVGFLVVK---VSATDVDTGVNGEISYSLFQASEEI 289
Query: 837 ---FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
F ++ TG ++ + LD EK Y++++ ARD G S + ++I + D ND+ PE
Sbjct: 290 GKTFKINPLTGEIE-LKKQLDFEKLQSYEVNIEARDAGTFSGKCTVLIQVIDVNDHAPE 347
Score = 72.1 bits (169), Expect = 1e-11
Identities = 70/237 (29%), Positives = 97/237 (40%), Gaps = 17/237 (7%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
+I+V N A +V IPEN P T + + DLDSG NG+I + +P
Sbjct: 335 LIQVIDVNDHAPEVTMSAFTSPIPENAP-ETVVALFSVSDLDSGENGKISCSIQED--LP 391
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVFVKD 1037
SA+ Y ++ ER + R E + ++ L L +++ V + D
Sbjct: 392 FLLKSAENF----YTLLTERP----LDRESRAEYNITITVTDLGTPMLITQLNMTVLIAD 443
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSDTDLPF--- 1093
VND+ P F +T Y V E + V ATD D G NA +TY + P D LP
Sbjct: 444 VNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSL 503
Query: 1094 -EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
I+ G L LD E + V A D+G D NDNSP
Sbjct: 504 VSINADNGHLFALRSLDYEALQGFQFRVGASDHG-SPALSSEALVRVVVLDANDNSP 559
Score = 63.3 bits (147), Expect = 6e-09
Identities = 82/328 (25%), Positives = 137/328 (41%), Gaps = 30/328 (9%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP------SLTIP 131
S +V + + DVND+ P + + + E P A +F ++ + S +I
Sbjct: 329 SGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENAPETVVA-LFSVSDLDSGENGKISCSIQ 387
Query: 132 LTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDY 190
+P L ++ ++P S Y+I ++ D G L + +L+ V D
Sbjct: 388 EDLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIADVNDN 447
Query: 191 DAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLFS 245
+ + + + L + A D+D G A + Y L+ D L S
Sbjct: 448 APAFTQTSYTLFV--RENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSLVS 505
Query: 246 LDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPE 305
+++ NG LF + LD +A LQ F +V AS +P +++A V + +LD NDN P
Sbjct: 506 INADNGHLFALRSLDYEA---LQG--FQFRVGASDHGSPALSSEALVRVVVLDANDNSPF 560
Query: 306 FEVDFYNIS--IVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPR 357
N S E +P G+ V +V+A D D G+N +YQL G F +
Sbjct: 561 VLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAH 620
Query: 358 SGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+G VR +L + R+ V K+
Sbjct: 621 NG--EVRTARLLSERDAAKHRLVVLVKD 646
Score = 57.6 bits (133), Expect = 3e-07
Identities = 60/201 (29%), Positives = 88/201 (43%), Gaps = 21/201 (10%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
LF+ N P I ++A D DSG N Q+ Y +PP L + IN
Sbjct: 458 LFVRENNSP-ALHIRSVSATDRDSGTNAQVTYSL-----LPPQD---PHLPLTSLVSINA 508
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+GH+ RSL E+ F+ + A D G+ L+ VRV V D ND+ P N
Sbjct: 509 DNGHLFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSPFVLYPLQNG 568
Query: 1053 NVEEAQYTRR------VLGKVDATDADFGQNANLTY-FIQPSDTDLPFEISPLTGVLSVN 1105
+ + R ++ KV A D D GQNA L+Y ++ ++ L F + G +
Sbjct: 569 SAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGL-FGVWAHNGEVRTA 627
Query: 1106 GELDRETEDKYILTVVARDNG 1126
L K+ L V+ +DNG
Sbjct: 628 RLLSERDAAKHRLVVLVKDNG 648
Score = 52.8 bits (121), Expect = 9e-06
Identities = 63/244 (25%), Positives = 105/244 (43%), Gaps = 21/244 (8%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
E + + LDRE + + F + S +Q + + D ND+ PVF
Sbjct: 81 ETADLLLNEKLDREDLCGHTEPCVLRFQVLLESPFEFFQAELQVIDINDHSPVFLDKQML 140
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----I 849
+ E+S GT + N A D D G N + Y + + + K+ +
Sbjct: 141 VKVSESSPPGTTFPLKN---AEDLDVGQNNIENYIISPNSYFRVLTRKRSDGRKYPELVL 197
Query: 850 GDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRE 907
+LDRE++ +L+L A D G S A++ I + D NDN PEF Q +V+I +
Sbjct: 198 DKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQ--PFYRVQISED 255
Query: 908 TKLNGTAGFTIIEVKPKNKFALDVDQLGPL--FLIPENIPIGTTIIKLNALDLDSGLNGQ 965
+ + GF +++V + +D G + L + IG T K+N L + L Q
Sbjct: 256 SPV----GFLVVKVSATD---VDTGVNGEISYSLFQASEEIGKT-FKINPLTGEIELKKQ 307
Query: 966 IRYE 969
+ +E
Sbjct: 308 LDFE 311
Score = 46.4 bits (105), Expect = 8e-04
Identities = 38/121 (31%), Positives = 48/121 (39%), Gaps = 5/121 (4%)
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFE 1094
V D+NDH PVF V E+ +A D D GQN Y I P+
Sbjct: 124 VIDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENYIISPNSYFRVLT 183
Query: 1095 ISPLTG----VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
G L ++ LDRE E + LT+ A D G DVNDN+P+
Sbjct: 184 RKRSDGRKYPELVLDKALDREEEAELRLTLTALDGG-SPPRSGTAQVYIEVLDVNDNAPE 242
Query: 1151 F 1151
F
Sbjct: 243 F 243
Score = 42.7 bits (96), Expect = 0.010
Identities = 39/126 (30%), Positives = 55/126 (43%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 541 LSSEALVRVVVLDANDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 599
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + L + + N T + S +H L V D P +L
Sbjct: 600 AWLSYQLLKATELGLFGVWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 658
Query: 553 AVVTIE 558
V+ ++
Sbjct: 659 HVLLVD 664
Score = 35.1 bits (77), Expect = 2.0
Identities = 38/154 (24%), Positives = 67/154 (43%), Gaps = 10/154 (6%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
++S ++ L+ L L ++LD + VL+ Q L +P + QA E+
Sbjct: 67 VVSRGNKLHLQLNQETADLLLNEKLDREDLCG-HTEPCVLRFQVL-LESPFEFFQA--EL 122
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
+++D+ND+ P F + + E+ P G + A D D G+N Y + P F +
Sbjct: 123 QVIDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENY-IISPNSYFRV 181
Query: 355 DPRS-----GWLTVRNQTVLDREAHSSLRMKVYA 383
R + + LDRE + LR+ + A
Sbjct: 182 LTRKRSDGRKYPELVLDKALDREEEAELRLTLTA 215
Score = 33.5 bits (73), Expect = 6.0
Identities = 16/36 (44%), Positives = 20/36 (55%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE 108
G + L++TV I DVNDN P F T Y + V E
Sbjct: 427 GTPMLITQLNMTVLIADVNDNAPAFTQTSYTLFVRE 462
>AF152492-1|AAD43753.1| 798|Homo sapiens protocadherin beta 13
protein.
Length = 798
Score = 109 bits (262), Expect = 7e-23
Identities = 136/507 (26%), Positives = 224/507 (44%), Gaps = 63/507 (12%)
Query: 929 LDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
+D++ P+FL + E+ P GTT NA DLD G N N E YI
Sbjct: 125 IDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQN-------NIENYIISPNS 177
Query: 982 SADALEVKRYFVINERHGHVIVARSLP--PESEFRLNISALDGGNLNDNISVRVFVK--D 1037
L KR ++ +++ ++L E+E RL ++ALDGG+ + + +V+++ D
Sbjct: 178 YFRVLTRKRSD--GRKYPELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLD 235
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDL--PFEI 1095
VND+ P F++ +Y + E ++ KV ATD D G N ++Y + + ++ F+I
Sbjct: 236 VNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQASEEIGKTFKI 295
Query: 1096 SPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK--FYA 1153
+PLTG + + +LD E Y + + ARD G DVND++P+ A
Sbjct: 296 NPLTGEIELKKQLDFEKLQSYEVNIEARDAG---TFSGKCTVLIQVIDVNDHAPEVTMSA 352
Query: 1154 FDELLEWKHPE--ADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFAN-DTDFIGNG 1210
F + PE S + +S + +I+E+ P A+ F T+ +
Sbjct: 353 FTSPIPENAPETVVALFSVSDLDSGENGKI-SCSIQEDLPFLLKSAENFYTLLTERPLDR 411
Query: 1211 NGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENV 1270
Y++ +LG P L + + V +ADV D + P F Y L + EN
Sbjct: 412 ESRAEYNI--TITVTDLGTPMLITQLNMTVLIADVND-----NAPAFTQTSYTLFVRENN 464
Query: 1271 NAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREVK 1326
+ + + S++ T+ N ++ Y +L D + T + I+ NG L+ +RS D E
Sbjct: 465 SPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSLVSINADNGHLFALRSLDYEAL 524
Query: 1327 DTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTN 1382
++ V A H ++ + L V+VVV D NDNSP N
Sbjct: 525 QGFQFRVGAS--------DHGSPALSSEAL-------VRVVV--LDANDNSPFVLYPLQN 567
Query: 1383 GNRPLVTAIPTTAPFGYQVMQLKGAIG 1409
G+ P +P A GY V ++ G
Sbjct: 568 GSAPCTELVPRAAEPGYLVTKVVAVDG 594
Score = 106 bits (255), Expect = 5e-22
Identities = 122/471 (25%), Positives = 198/471 (42%), Gaps = 39/471 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E F E+ ++D ND++PVF+ + + ++ GT A D D+GQN +
Sbjct: 112 ESPFEFFQAELQVIDINDHSPVFLDKQML-VKVSESSPPGTTFPLKNAEDLDVGQNNIEN 170
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHA---LFVEASDQPANPSERRYSLA 553
Y + S + + + + V + + A L + A D + P R A
Sbjct: 171 YIISPNSYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTALDGGSPP---RSGTA 227
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLL 611
V IEV + P+F Y + + +G V ++ D ++SY L
Sbjct: 228 QVYIEVL----DVNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLF 283
Query: 612 HGYEE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
EE G F + +G I + L Y+ A ++ S + V+DVN
Sbjct: 284 QASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEA-RDAGTFSGKCTVLIQVIDVN 342
Query: 671 DERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D V + SPI EN+ + +F ++S + G + I Q+D+
Sbjct: 343 DHAPEVTMSAFTSPI----PENAPETVVA-LF--SVSDLDSGENGKISCSI--QEDLPFL 393
Query: 730 IAIAEDG-TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ AE+ T+ T++PLDRE R Y +T+ + G +T+ I D NDN P F
Sbjct: 394 LKSAENFYTLLTERPLDRESRAEYNITITVT-DLGTPMLITQLNMTVLIADVNDNAPAFT 452
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDEN 842
+Y F+ EN+ I+ + ATD D GTNA Y+L + ++ +
Sbjct: 453 QTSYTLFVRENNSPALHIRS---VSATDRDSGTNAQVTYSLLPPQDPHLPLTSLVSINAD 509
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
G + F SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 510 NGHL-FALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSP 559
Score = 85.4 bits (202), Expect = 1e-15
Identities = 71/245 (28%), Positives = 111/245 (45%), Gaps = 21/245 (8%)
Query: 911 NGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEF 970
+GTA IEV N A + +Q I E+ P+G ++K++A D+D+G+NG+I Y
Sbjct: 224 SGTAQ-VYIEVLDVNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISY-- 280
Query: 971 NSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDN 1028
L + E+ + F IN G + + + L E + +NI A D G +
Sbjct: 281 ---------SLFQASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGTFSGK 331
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
+V + V DVNDH P + + + E V+ +D D G+N ++ IQ
Sbjct: 332 CTVLIQVIDVNDHAPEVTMSAFTSPIPE-NAPETVVALFSVSDLDSGENGKISCSIQ--- 387
Query: 1089 TDLPFEISPLTGVLSVNGE--LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
DLPF + ++ E LDRE+ +Y +T+ D G DVND
Sbjct: 388 EDLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLG-TPMLITQLNMTVLIADVND 446
Query: 1147 NSPKF 1151
N+P F
Sbjct: 447 NAPAF 451
Score = 83.4 bits (197), Expect = 6e-15
Identities = 52/137 (37%), Positives = 78/137 (56%), Gaps = 11/137 (8%)
Query: 253 LFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN 312
L L+K LD + E L+ L + A +P ++ A+V IE+LD+NDN PEFE FY
Sbjct: 195 LVLDKALDREEEAELR-----LTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQPFYR 249
Query: 313 ISIVENLPNGFSVLQVMATDKDQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTV 368
+ I E+ P GF V++V ATD D G NGE +Y L ++ F I+P +G + ++ Q
Sbjct: 250 VQISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQASEEIGKTFKINPLTGEIELKKQ-- 307
Query: 369 LDREAHSSLRMKVYAKE 385
LD E S + + A++
Sbjct: 308 LDFEKLQSYEVNIEARD 324
Score = 83.0 bits (196), Expect = 7e-15
Identities = 71/239 (29%), Positives = 111/239 (46%), Gaps = 19/239 (7%)
Query: 662 ATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLI 720
A + V+D+ND V L ++ V E+S G F + G N+ ++I
Sbjct: 120 AELQVIDINDHSPVFLD---KQMLVKVSESSPP---GTTFPLKNAEDLDVGQNNIENYII 173
Query: 721 ANQQDVTDDIAIAEDGTIFTQ----KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIY 776
+ DG + + K LDRE+ R+T+ A + G +G QV I
Sbjct: 174 SPNSYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTA-LDGGSPPRSGTAQVYIE 232
Query: 777 IEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM 836
+ D NDN P FE Y I E+S +G + + ATD D G N Y+LF +E+
Sbjct: 233 VLDVNDNAPEFEQPFYRVQISEDSPVGFLVVK---VSATDVDTGVNGEISYSLFQASEEI 289
Query: 837 ---FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
F ++ TG ++ + LD EK Y++++ ARD G S + ++I + D ND+ PE
Sbjct: 290 GKTFKINPLTGEIE-LKKQLDFEKLQSYEVNIEARDAGTFSGKCTVLIQVIDVNDHAPE 347
Score = 72.1 bits (169), Expect = 1e-11
Identities = 70/237 (29%), Positives = 97/237 (40%), Gaps = 17/237 (7%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
+I+V N A +V IPEN P T + + DLDSG NG+I + +P
Sbjct: 335 LIQVIDVNDHAPEVTMSAFTSPIPENAP-ETVVALFSVSDLDSGENGKISCSIQED--LP 391
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVFVKD 1037
SA+ Y ++ ER + R E + ++ L L +++ V + D
Sbjct: 392 FLLKSAENF----YTLLTERP----LDRESRAEYNITITVTDLGTPMLITQLNMTVLIAD 443
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSDTDLPF--- 1093
VND+ P F +T Y V E + V ATD D G NA +TY + P D LP
Sbjct: 444 VNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSL 503
Query: 1094 -EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
I+ G L LD E + V A D+G D NDNSP
Sbjct: 504 VSINADNGHLFALRSLDYEALQGFQFRVGASDHG-SPALSSEALVRVVVLDANDNSP 559
Score = 63.3 bits (147), Expect = 6e-09
Identities = 82/328 (25%), Positives = 137/328 (41%), Gaps = 30/328 (9%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP------SLTIP 131
S +V + + DVND+ P + + + E P A +F ++ + S +I
Sbjct: 329 SGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENAPETVVA-LFSVSDLDSGENGKISCSIQ 387
Query: 132 LTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDY 190
+P L ++ ++P S Y+I ++ D G L + +L+ V D
Sbjct: 388 EDLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIADVNDN 447
Query: 191 DAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLFS 245
+ + + + L + A D+D G A + Y L+ D L S
Sbjct: 448 APAFTQTSYTLFV--RENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSLVS 505
Query: 246 LDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPE 305
+++ NG LF + LD +A LQ F +V AS +P +++A V + +LD NDN P
Sbjct: 506 INADNGHLFALRSLDYEA---LQG--FQFRVGASDHGSPALSSEALVRVVVLDANDNSPF 560
Query: 306 FEVDFYNIS--IVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPR 357
N S E +P G+ V +V+A D D G+N +YQL G F +
Sbjct: 561 VLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAH 620
Query: 358 SGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+G VR +L + R+ V K+
Sbjct: 621 NG--EVRTARLLSERDAAKHRLVVLVKD 646
Score = 57.6 bits (133), Expect = 3e-07
Identities = 60/201 (29%), Positives = 88/201 (43%), Gaps = 21/201 (10%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
LF+ N P I ++A D DSG N Q+ Y +PP L + IN
Sbjct: 458 LFVRENNSP-ALHIRSVSATDRDSGTNAQVTYSL-----LPPQD---PHLPLTSLVSINA 508
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+GH+ RSL E+ F+ + A D G+ L+ VRV V D ND+ P N
Sbjct: 509 DNGHLFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSPFVLYPLQNG 568
Query: 1053 NVEEAQYTRR------VLGKVDATDADFGQNANLTY-FIQPSDTDLPFEISPLTGVLSVN 1105
+ + R ++ KV A D D GQNA L+Y ++ ++ L F + G +
Sbjct: 569 SAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGL-FGVWAHNGEVRTA 627
Query: 1106 GELDRETEDKYILTVVARDNG 1126
L K+ L V+ +DNG
Sbjct: 628 RLLSERDAAKHRLVVLVKDNG 648
Score = 52.8 bits (121), Expect = 9e-06
Identities = 63/244 (25%), Positives = 105/244 (43%), Gaps = 21/244 (8%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
E + + LDRE + + F + S +Q + + D ND+ PVF
Sbjct: 81 ETADLLLNEKLDREDLCGHTEPCVLRFQVLLESPFEFFQAELQVIDINDHSPVFLDKQML 140
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----I 849
+ E+S GT + N A D D G N + Y + + + K+ +
Sbjct: 141 VKVSESSPPGTTFPLKN---AEDLDVGQNNIENYIISPNSYFRVLTRKRSDGRKYPELVL 197
Query: 850 GDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRE 907
+LDRE++ +L+L A D G S A++ I + D NDN PEF Q +V+I +
Sbjct: 198 DKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQ--PFYRVQISED 255
Query: 908 TKLNGTAGFTIIEVKPKNKFALDVDQLGPL--FLIPENIPIGTTIIKLNALDLDSGLNGQ 965
+ + GF +++V + +D G + L + IG T K+N L + L Q
Sbjct: 256 SPV----GFLVVKVSATD---VDTGVNGEISYSLFQASEEIGKT-FKINPLTGEIELKKQ 307
Query: 966 IRYE 969
+ +E
Sbjct: 308 LDFE 311
Score = 46.4 bits (105), Expect = 8e-04
Identities = 38/121 (31%), Positives = 48/121 (39%), Gaps = 5/121 (4%)
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFE 1094
V D+NDH PVF V E+ +A D D GQN Y I P+
Sbjct: 124 VIDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENYIISPNSYFRVLT 183
Query: 1095 ISPLTG----VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
G L ++ LDRE E + LT+ A D G DVNDN+P+
Sbjct: 184 RKRSDGRKYPELVLDKALDREEEAELRLTLTALDGG-SPPRSGTAQVYIEVLDVNDNAPE 242
Query: 1151 F 1151
F
Sbjct: 243 F 243
Score = 42.7 bits (96), Expect = 0.010
Identities = 39/126 (30%), Positives = 55/126 (43%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 541 LSSEALVRVVVLDANDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 599
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + L + + N T + S +H L V D P +L
Sbjct: 600 AWLSYQLLKATELGLFGVWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 658
Query: 553 AVVTIE 558
V+ ++
Sbjct: 659 HVLLVD 664
Score = 35.1 bits (77), Expect = 2.0
Identities = 38/154 (24%), Positives = 67/154 (43%), Gaps = 10/154 (6%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
++S ++ L+ L L ++LD + VL+ Q L +P + QA E+
Sbjct: 67 VVSRGNKLHLQLNQETADLLLNEKLDREDLCG-HTEPCVLRFQVL-LESPFEFFQA--EL 122
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
+++D+ND+ P F + + E+ P G + A D D G+N Y + P F +
Sbjct: 123 QVIDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENY-IISPNSYFRV 181
Query: 355 DPRS-----GWLTVRNQTVLDREAHSSLRMKVYA 383
R + + LDRE + LR+ + A
Sbjct: 182 LTRKRSDGRKYPELVLDKALDREEEAELRLTLTA 215
Score = 33.5 bits (73), Expect = 6.0
Identities = 16/36 (44%), Positives = 20/36 (55%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE 108
G + L++TV I DVNDN P F T Y + V E
Sbjct: 427 GTPMLITQLNMTVLIADVNDNAPAFTQTSYTLFVRE 462
>BC132769-1|AAI32770.1| 828|Homo sapiens protocadherin gamma
subfamily A, 9 protein.
Length = 828
Score = 109 bits (261), Expect = 1e-22
Identities = 126/479 (26%), Positives = 207/479 (43%), Gaps = 39/479 (8%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
N + E + +E+ + D ND+ P F +L E + A G +A+DPD+G
Sbjct: 105 NFKVLVEDRVKLYGIEIEVTDINDSAPKFQAESL-EVKINEIAVPGARYPLPEAIDPDVG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR---HALFVEASDQPANPSE 547
N + Y L + ++ N V E + H L + ASD E
Sbjct: 164 VNSLQSYQLSPNHHFSLNVQTGDNGAINPELVLERALDREEATAHHLVLTASDG----GE 219
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QND 605
R S + V I VT + P F Y V NV GT + +D E
Sbjct: 220 PRRS-STVRIHVT--VLDTNDNAPVFAQRIYRVKVLENVPPGTWLLTATASDLDEGINGK 276
Query: 606 VSYDLLHGYE-EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
V+Y E + + F + E +G I+ L Y+ E A ++ L T +
Sbjct: 277 VAYKFWKINEKQSLLFQLNENTGEISTAKSLDYEECSFYEMEIQA-EDGGGLKGWTKVLI 335
Query: 665 HVVDVNDERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
V DVND R V + SP V+E++ + +F+ + NG + + + Q
Sbjct: 336 SVEDVNDNRPEVTITSLFSP----VREDAPQGTVILLFNAHDRDSGKNG----QVVCSIQ 387
Query: 724 QDVTDDIAIAEDG--TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
++++ + +E+ + T + LDREK Y +TV A ++G + +T+ + D N
Sbjct: 388 ENLSFTLENSEEDYYRLLTAQILDREKASEYNITVTAT-DRGTPPLSTEIHITLQVTDIN 446
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEM-- 836
DNPP F A+Y ++ EN+ GT I + A D D N+ +Y+L +G +
Sbjct: 447 DNPPAFSQASYSVYLPENNARGTSIFS---VIAYDPDSNENSRVIYSLAEDTIQGSPLST 503
Query: 837 -FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
++ +TGV+ + S D E+ ++ + A D+G LSS L + + D+NDN PE
Sbjct: 504 YVSINSDTGVL-YALCSFDYEQFRDLQMQVTASDSGSPPLSSNVSLRLFVLDQNDNAPE 561
Score = 85.8 bits (203), Expect = 1e-15
Identities = 111/420 (26%), Positives = 171/420 (40%), Gaps = 53/420 (12%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
GT+ T +DRE+ + F V +Y + I + D ND+ P F+ + E
Sbjct: 82 GTLVTAGRIDREELCAQSPRCLVNFKVLVEDRVKLYGIEIEVTDINDSAPKFQAESLEVK 141
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
I E + G + +A D D G N+L Y L F ++ TG I L
Sbjct: 142 INEIAVPGARYPLP---EAIDPDVGVNSLQSYQL--SPNHHFSLNVQTGDNGAINPELVL 196
Query: 856 EKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAG 915
E+ + R+ ++ L++ D + + +S VRIH
Sbjct: 197 ERAL-------DREE---ATAHHLVLTASDGGEPR-------RSSTVRIH---------- 229
Query: 916 FTIIEVKPKNK-FALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEV 974
T+++ FA + ++ L EN+P GT ++ A DLD G+NG++ Y+F
Sbjct: 230 VTVLDTNDNAPVFAQRIYRVKVL----ENVPPGTWLLTATASDLDEGINGKVAYKF---- 281
Query: 975 YIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDNISVR 1032
K++ + F +NE G + A+SL E S + + I A DGG L V
Sbjct: 282 ----WKINE---KQSLLFQLNENTGEISTAKSLDYEECSFYEMEIQAEDGGGLKGWTKVL 334
Query: 1033 VFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP 1092
+ V+DVND+ P T V E V+ +A D D G+N + IQ +
Sbjct: 335 ISVEDVNDNRPEVTITSLFSPVREDAPQGTVILLFNAHDRDSGKNGQVVCSIQ-ENLSFT 393
Query: 1093 FEISPLTGVLSVNGE-LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
E S + + LDRE +Y +TV A D G D+NDN P F
Sbjct: 394 LENSEEDYYRLLTAQILDREKASEYNITVTATDRG-TPPLSTEIHITLQVTDINDNPPAF 452
Score = 77.0 bits (181), Expect = 5e-13
Identities = 110/463 (23%), Positives = 194/463 (41%), Gaps = 38/463 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S V + VT+LD NDN PVF +Y + N GT + A D D G NG V Y
Sbjct: 224 STVRIHVTVLDTNDNAPVFA-QRIYRVKVLENVPPGTWLLTATASDLDEGINGKVAYKFW 282
Query: 501 RTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERR-YSLAVVTIEV 559
+ N + F++N NTG +S A+S L+ F E Q + + ++ ++++E
Sbjct: 283 KI-NEKQSLLFQLNENTGEISTAKS--LDYEECSFYEMEIQAEDGGGLKGWTKVLISVE- 338
Query: 560 TRGTKGNKPDIP-DFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGV 618
N+P++ + +P V + GT + +D + + ++ +E +
Sbjct: 339 --DVNDNRPEVTITSLFSP----VREDAPQGTVILLFNAHD--RDSGKNGQVVCSIQENL 390
Query: 619 PFAVE---ERSGVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDERG 674
F +E E + L R Y+ A LS + T+ V D+ND
Sbjct: 391 SFTLENSEEDYYRLLTAQILDREKASEYNITVTATDRGTPPLSTEIHITLQVTDINDNPP 450
Query: 675 VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ----QDVTDDI 730
+ ++S ++ + N+ G +I + + S N V + +A ++ +
Sbjct: 451 AFSQASYS--VYLPENNARGTSIFSVIAYDPDS---NENSRVIYSLAEDTIQGSPLSTYV 505
Query: 731 AIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP--VF 787
+I D G ++ D E+ +M V A + G + + +++ D+NDN P ++
Sbjct: 506 SINSDTGVLYALCSFDYEQFRDLQMQVTAS-DSGSPPLSSNVSLRLFVLDQNDNAPEILY 564
Query: 788 EHATYEGFI-MENSKIGTEIK-MDNIIKATDADEGTNALFMYTLFGEGKE-MFDVDENTG 844
+G +E + E + + A D D G NA Y LF + +F V +TG
Sbjct: 565 PALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLFKASEPGLFSVGLHTG 624
Query: 845 VVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
V+ LDR+ + L + +D G LS+ L + I D
Sbjct: 625 EVRTARALLDRD-ALKQSLVVAVQDHGQPPLSATVTLTVAIAD 666
Score = 72.5 bits (170), Expect = 1e-11
Identities = 49/176 (27%), Positives = 85/176 (48%), Gaps = 8/176 (4%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
+P P AID D+GV + Y+L + L NG++ E L+ + +A
Sbjct: 152 YPLP-EAIDPDVGVNSLQSYQLSPNHHFSLNVQTGDNGAINPELVLERALDRE-EATAHH 209
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L + AS P +++ R+ + +LD NDN P F Y + ++EN+P G +L A+D
Sbjct: 210 LVLTASDGGEPRRSSTVRIHVTVLDTNDNAPVFAQRIYRVKVLENVPPGTWLLTATASDL 269
Query: 334 DQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D+G NG+ Y+ + F ++ +G ++ LD E S M++ A++
Sbjct: 270 DEGINGKVAYKFWKINEKQSLLFQLNENTGEISTAKS--LDYEECSFYEMEIQAED 323
Score = 68.1 bits (159), Expect = 2e-10
Identities = 57/190 (30%), Positives = 84/190 (44%), Gaps = 11/190 (5%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I T K LD E+ Y M + AE G+ G +V I +ED NDN P +
Sbjct: 299 GEISTAKSLDYEECSFYEMEIQAEDGGGL---KGWTKVLISVEDVNDNRPEVTITSLFSP 355
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
+ E++ GT I + N A D D G N + ++ + E LDR
Sbjct: 356 VREDAPQGTVILLFN---AHDRDSGKNGQVVCSIQENLSFTLENSEEDYYRLLTAQILDR 412
Query: 856 EKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
EK Y +++ A D G LS+E + + + D NDN P F+Q + + E GT
Sbjct: 413 EKASEYNITVTATDRGTPPLSTEIHITLQVTDINDNPPAFSQASYSVYL---PENNARGT 469
Query: 914 AGFTIIEVKP 923
+ F++I P
Sbjct: 470 SIFSVIAYDP 479
Score = 58.0 bits (134), Expect = 2e-07
Identities = 66/250 (26%), Positives = 100/250 (40%), Gaps = 25/250 (10%)
Query: 912 GTAGFT--IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
G G+T +I V+ N +V + E+ P GT I+ NA D DSG NGQ+
Sbjct: 326 GLKGWTKVLISVEDVNDNRPEVTITSLFSPVREDAPQGTVILLFNAHDRDSGKNGQVVCS 385
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN--L 1025
+ D Y+ ++ A+ L E SE+ + ++A D G L
Sbjct: 386 IQENLSFTLENSEED------YY-------RLLTAQILDREKASEYNITVTATDRGTPPL 432
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY--- 1082
+ I + + V D+ND+ P F + Y+ + E + V A D D +N+ + Y
Sbjct: 433 STEIHITLQVTDINDNPPAFSQASYSVYLPENNARGTSIFSVIAYDPDSNENSRVIYSLA 492
Query: 1083 --FIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXX 1140
IQ S I+ TGVL D E + V A D+G
Sbjct: 493 EDTIQGSPLSTYVSINSDTGVLYALCSFDYEQFRDLQMQVTASDSG-SPPLSSNVSLRLF 551
Query: 1141 XXDVNDNSPK 1150
D NDN+P+
Sbjct: 552 VLDQNDNAPE 561
Score = 57.2 bits (132), Expect = 4e-07
Identities = 63/199 (31%), Positives = 93/199 (46%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN GT+I + A D DS N ++ Y +E I S LS Y IN G
Sbjct: 461 LPENNARGTSIFSVIAYDPDSNENSRVIYSL-AEDTIQGSPLST-------YVSINSDTG 512
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK----KTWYN 1051
+ S E + ++ ++A D G+ L+ N+S+R+FV D ND+ P T +
Sbjct: 513 VLYALCSFDYEQFRDLQMQVTASDSGSPPLSSNVSLRLFVLDQNDNAPEILYPALPTDGS 572
Query: 1052 FNVEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG-VLSVNGE 1107
VE A + ++ KV A D D GQNA L+Y + + F + TG V +
Sbjct: 573 TGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLFKASEPGLFSVGLHTGEVRTARAL 632
Query: 1108 LDRETEDKYILTVVARDNG 1126
LDR+ K L V +D+G
Sbjct: 633 LDRDAL-KQSLVVAVQDHG 650
Score = 56.0 bits (129), Expect = 1e-06
Identities = 43/176 (24%), Positives = 77/176 (43%), Gaps = 9/176 (5%)
Query: 220 AIDQDLGVGATLRYELISGNDRK--LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
A D D G+ + Y+ N+++ LF L+ G + K LD + + + + +++Q
Sbjct: 266 ASDLDEGINGKVAYKFWKINEKQSLLFQLNENTGEISTAKSLDYE-----ECSFYEMEIQ 320
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A LK +V I + D+NDN PE + + E+ P G +L A D+D G+
Sbjct: 321 AED-GGGLK-GWTKVLISVEDVNDNRPEVTITSLFSPVREDAPQGTVILLFNAHDRDSGK 378
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
NG+ + + + + + +LDRE S + V A + + T
Sbjct: 379 NGQVVCSIQENLSFTLENSEEDYYRLLTAQILDREKASEYNITVTATDRGTPPLST 434
Score = 52.4 bits (120), Expect = 1e-05
Identities = 34/126 (26%), Positives = 61/126 (48%), Gaps = 9/126 (7%)
Query: 268 QANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQ 327
+A+ + + V A+ P + + + +++ D+NDN P F Y++ + EN G S+
Sbjct: 414 KASEYNITVTATDRGTPPLSTEIHITLQVTDINDNPPAFSQASYSVYLPENNARGTSIFS 473
Query: 328 VMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQT-VL------DREAHSSLRMK 380
V+A D D EN Y L + P S ++++ + T VL D E L+M+
Sbjct: 474 VIAYDPDSNENSRVIYSL--AEDTIQGSPLSTYVSINSDTGVLYALCSFDYEQFRDLQMQ 531
Query: 381 VYAKET 386
V A ++
Sbjct: 532 VTASDS 537
Score = 50.0 bits (114), Expect = 6e-05
Identities = 80/337 (23%), Positives = 132/337 (39%), Gaps = 33/337 (9%)
Query: 59 CDFDEGDDLVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFI 118
C F E + G GL + V + +EDVNDN P T V E P G +
Sbjct: 312 CSFYEMEIQAEDGGGLK---GWTKVLISVEDVNDNRPEVTITSLFSPVREDAPQGTVILL 368
Query: 119 FLI--APIGPSLTIPLTVPRGLTIFKDIRAFDRDKPNTPN-----SDVHYSI-VSGNDDG 170
F G + + ++ L+ + D + T Y+I V+ D G
Sbjct: 369 FNAHDRDSGKNGQVVCSIQENLSFTLENSEEDYYRLLTAQILDREKASEYNITVTATDRG 428
Query: 171 HFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGAT 230
L + L + + D + + +F + A D D +
Sbjct: 429 TPPLSTEIHITLQVTDINDNPPAFSQASYSVYLPENNARGTSIFS--VIAYDPDSNENSR 486
Query: 231 LRYEL----ISGNDRKLF-SLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPL 285
+ Y L I G+ + S++S G L+ D + +LQ +QV AS +P
Sbjct: 487 VIYSLAEDTIQGSPLSTYVSINSDTGVLYALCSFDYEQFRDLQ-----MQVTASDSGSPP 541
Query: 286 KTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLPN----GFSVLQVMATDKDQGEN 338
++ + + +LD NDN PE + + VE P G+ V +V+A D+D G+N
Sbjct: 542 LSSNVSLRLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQN 601
Query: 339 GEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREA 373
+Y+L G FS+ +G + + +LDR+A
Sbjct: 602 AWLSYRLFKASEPGLFSVGLHTGEVRTA-RALLDRDA 637
Score = 42.3 bits (95), Expect = 0.013
Identities = 37/131 (28%), Positives = 60/131 (45%), Gaps = 5/131 (3%)
Query: 229 ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTA 288
A R ++S +LFSL+ +G+L +D + L A + V L +
Sbjct: 60 AERRVRIVSRGRTQLFSLNPRSGTLVTAGRIDRE---ELCAQSPRCLVNFKVLVED-RVK 115
Query: 289 QARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDP 348
+EIE+ D+ND+ P+F+ + + I E G A D D G N +YQL P
Sbjct: 116 LYGIEIEVTDINDSAPKFQAESLEVKINEIAVPGARYPLPEAIDPDVGVNSLQSYQL-SP 174
Query: 349 KGAFSIDPRSG 359
FS++ ++G
Sbjct: 175 NHHFSLNVQTG 185
Score = 41.5 bits (93), Expect = 0.022
Identities = 45/156 (28%), Positives = 68/156 (43%), Gaps = 27/156 (17%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P SST + VTV D D PVF R Y +++ ENV L++ ++ E
Sbjct: 218 GEPRRSSTVRIHVTVLDTNDNA-----PVFAQRIYRVKVLENVPPGTWLLTATASDLDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
N K+ Y N+ F ++ G + +S D E YE+ ++AE
Sbjct: 273 INGKVAYKFWKINEKQ-SLLFQLNENTGEISTAKSLDYEECSFYEMEIQAE--------- 322
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
L+G T KV++ ++DVNDN P+ T
Sbjct: 323 ------DGGGLKGWT----KVLISVEDVNDNRPEVT 348
Score = 38.3 bits (85), Expect = 0.21
Identities = 38/125 (30%), Positives = 58/125 (46%), Gaps = 13/125 (10%)
Query: 439 LMSFVNVEVTLLDANDNNP-VFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPDLGQ 491
L S V++ + +LD NDN P + P S E + +S A+ G ++ KV AVD D GQ
Sbjct: 542 LSSNVSLRLFVLDQNDNAPEILYPALPTDGSTGVELAPRS-AEPGYLVTKVVAVDRDSGQ 600
Query: 492 NGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERR 549
N + Y L + S + F + +TG V A + + + +L V D P
Sbjct: 601 NAWLSYRLFKASEPGL---FSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSAT 657
Query: 550 YSLAV 554
+L V
Sbjct: 658 VTLTV 662
>AF152516-1|AAD43776.1| 828|Homo sapiens protocadherin gamma A9
short form protein protein.
Length = 828
Score = 109 bits (261), Expect = 1e-22
Identities = 126/479 (26%), Positives = 207/479 (43%), Gaps = 39/479 (8%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
N + E + +E+ + D ND+ P F +L E + A G +A+DPD+G
Sbjct: 105 NFKVLVEDRVKLYGIEIEVTDINDSAPKFQAESL-EVKINEIAVPGARYPLPEAIDPDVG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR---HALFVEASDQPANPSE 547
N + Y L + ++ N V E + H L + ASD E
Sbjct: 164 VNSLQSYQLSPNHHFSLNVQTGDNGAINPELVLERALDREEATAHHLVLTASDG----GE 219
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QND 605
R S + V I VT + P F Y V NV GT + +D E
Sbjct: 220 PRRS-STVRIHVT--VLDTNDNAPVFAQRIYRVKVLENVPPGTWLLTATASDLDEGINGK 276
Query: 606 VSYDLLHGYE-EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
V+Y E + + F + E +G I+ L Y+ E A ++ L T +
Sbjct: 277 VAYKFWKINEKQSLLFQLNENTGEISTAKSLDYEECSFYEMEIQA-EDGGGLKGWTKVLI 335
Query: 665 HVVDVNDERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
V DVND R V + SP V+E++ + +F+ + NG + + + Q
Sbjct: 336 SVEDVNDNRPEVTITSLFSP----VREDAPQGTVILLFNAHDRDSGKNG----QVVCSIQ 387
Query: 724 QDVTDDIAIAEDG--TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
++++ + +E+ + T + LDREK Y +TV A ++G + +T+ + D N
Sbjct: 388 ENLSFTLENSEEDYYRLLTAQILDREKASEYNITVTAT-DRGTPPLSTEIHITLQVTDIN 446
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEM-- 836
DNPP F A+Y ++ EN+ GT I + A D D N+ +Y+L +G +
Sbjct: 447 DNPPAFSQASYSVYLPENNARGTSIFS---VIAYDPDSNENSRVIYSLAEDTIQGSPLST 503
Query: 837 -FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
++ +TGV+ + S D E+ ++ + A D+G LSS L + + D+NDN PE
Sbjct: 504 YVSINSDTGVL-YALCSFDYEQFRDLQMQVTASDSGSPPLSSNVSLRLFVLDQNDNAPE 561
Score = 85.8 bits (203), Expect = 1e-15
Identities = 111/420 (26%), Positives = 171/420 (40%), Gaps = 53/420 (12%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
GT+ T +DRE+ + F V +Y + I + D ND+ P F+ + E
Sbjct: 82 GTLVTAGRIDREELCAQSPRCLVNFKVLVEDRVKLYGIEIEVTDINDSAPKFQAESLEVK 141
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
I E + G + +A D D G N+L Y L F ++ TG I L
Sbjct: 142 INEIAVPGARYPLP---EAIDPDVGVNSLQSYQL--SPNHHFSLNVQTGDNGAINPELVL 196
Query: 856 EKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAG 915
E+ + R+ ++ L++ D + + +S VRIH
Sbjct: 197 ERAL-------DREE---ATAHHLVLTASDGGEPR-------RSSTVRIH---------- 229
Query: 916 FTIIEVKPKNK-FALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEV 974
T+++ FA + ++ L EN+P GT ++ A DLD G+NG++ Y+F
Sbjct: 230 VTVLDTNDNAPVFAQRIYRVKVL----ENVPPGTWLLTATASDLDEGINGKVAYKF---- 281
Query: 975 YIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDNISVR 1032
K++ + F +NE G + A+SL E S + + I A DGG L V
Sbjct: 282 ----WKINE---KQSLLFQLNENTGEISTAKSLDYEECSFYEMEIQAEDGGGLKGWTKVL 334
Query: 1033 VFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP 1092
+ V+DVND+ P T V E V+ +A D D G+N + IQ +
Sbjct: 335 ISVEDVNDNRPEVTITSLFSPVREDAPQGTVILLFNAHDRDSGKNGQVVCSIQ-ENLSFT 393
Query: 1093 FEISPLTGVLSVNGE-LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
E S + + LDRE +Y +TV A D G D+NDN P F
Sbjct: 394 LENSEEDYYRLLTAQILDREKASEYNITVTATDRG-TPPLSTEIHITLQVTDINDNPPAF 452
Score = 77.0 bits (181), Expect = 5e-13
Identities = 110/463 (23%), Positives = 194/463 (41%), Gaps = 38/463 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S V + VT+LD NDN PVF +Y + N GT + A D D G NG V Y
Sbjct: 224 STVRIHVTVLDTNDNAPVFA-QRIYRVKVLENVPPGTWLLTATASDLDEGINGKVAYKFW 282
Query: 501 RTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERR-YSLAVVTIEV 559
+ N + F++N NTG +S A+S L+ F E Q + + ++ ++++E
Sbjct: 283 KI-NEKQSLLFQLNENTGEISTAKS--LDYEECSFYEMEIQAEDGGGLKGWTKVLISVE- 338
Query: 560 TRGTKGNKPDIP-DFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGV 618
N+P++ + +P V + GT + +D + + ++ +E +
Sbjct: 339 --DVNDNRPEVTITSLFSP----VREDAPQGTVILLFNAHD--RDSGKNGQVVCSIQENL 390
Query: 619 PFAVE---ERSGVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDERG 674
F +E E + L R Y+ A LS + T+ V D+ND
Sbjct: 391 SFTLENSEEDYYRLLTAQILDREKASEYNITVTATDRGTPPLSTEIHITLQVTDINDNPP 450
Query: 675 VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ----QDVTDDI 730
+ ++S ++ + N+ G +I + + S N V + +A ++ +
Sbjct: 451 AFSQASYS--VYLPENNARGTSIFSVIAYDPDS---NENSRVIYSLAEDTIQGSPLSTYV 505
Query: 731 AIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP--VF 787
+I D G ++ D E+ +M V A + G + + +++ D+NDN P ++
Sbjct: 506 SINSDTGVLYALCSFDYEQFRDLQMQVTAS-DSGSPPLSSNVSLRLFVLDQNDNAPEILY 564
Query: 788 EHATYEGFI-MENSKIGTEIK-MDNIIKATDADEGTNALFMYTLFGEGKE-MFDVDENTG 844
+G +E + E + + A D D G NA Y LF + +F V +TG
Sbjct: 565 PALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLFKASEPGLFSVGLHTG 624
Query: 845 VVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
V+ LDR+ + L + +D G LS+ L + I D
Sbjct: 625 EVRTARALLDRD-ALKQSLVVAVQDHGQPPLSATVTLTVAIAD 666
Score = 72.5 bits (170), Expect = 1e-11
Identities = 49/176 (27%), Positives = 85/176 (48%), Gaps = 8/176 (4%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
+P P AID D+GV + Y+L + L NG++ E L+ + +A
Sbjct: 152 YPLP-EAIDPDVGVNSLQSYQLSPNHHFSLNVQTGDNGAINPELVLERALDRE-EATAHH 209
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L + AS P +++ R+ + +LD NDN P F Y + ++EN+P G +L A+D
Sbjct: 210 LVLTASDGGEPRRSSTVRIHVTVLDTNDNAPVFAQRIYRVKVLENVPPGTWLLTATASDL 269
Query: 334 DQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D+G NG+ Y+ + F ++ +G ++ LD E S M++ A++
Sbjct: 270 DEGINGKVAYKFWKINEKQSLLFQLNENTGEISTAKS--LDYEECSFYEMEIQAED 323
Score = 68.1 bits (159), Expect = 2e-10
Identities = 57/190 (30%), Positives = 84/190 (44%), Gaps = 11/190 (5%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I T K LD E+ Y M + AE G+ G +V I +ED NDN P +
Sbjct: 299 GEISTAKSLDYEECSFYEMEIQAEDGGGL---KGWTKVLISVEDVNDNRPEVTITSLFSP 355
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
+ E++ GT I + N A D D G N + ++ + E LDR
Sbjct: 356 VREDAPQGTVILLFN---AHDRDSGKNGQVVCSIQENLSFTLENSEEDYYRLLTAQILDR 412
Query: 856 EKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
EK Y +++ A D G LS+E + + + D NDN P F+Q + + E GT
Sbjct: 413 EKASEYNITVTATDRGTPPLSTEIHITLQVTDINDNPPAFSQASYSVYL---PENNARGT 469
Query: 914 AGFTIIEVKP 923
+ F++I P
Sbjct: 470 SIFSVIAYDP 479
Score = 58.0 bits (134), Expect = 2e-07
Identities = 66/250 (26%), Positives = 100/250 (40%), Gaps = 25/250 (10%)
Query: 912 GTAGFT--IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
G G+T +I V+ N +V + E+ P GT I+ NA D DSG NGQ+
Sbjct: 326 GLKGWTKVLISVEDVNDNRPEVTITSLFSPVREDAPQGTVILLFNAHDRDSGKNGQVVCS 385
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN--L 1025
+ D Y+ ++ A+ L E SE+ + ++A D G L
Sbjct: 386 IQENLSFTLENSEED------YY-------RLLTAQILDREKASEYNITVTATDRGTPPL 432
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY--- 1082
+ I + + V D+ND+ P F + Y+ + E + V A D D +N+ + Y
Sbjct: 433 STEIHITLQVTDINDNPPAFSQASYSVYLPENNARGTSIFSVIAYDPDSNENSRVIYSLA 492
Query: 1083 --FIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXX 1140
IQ S I+ TGVL D E + V A D+G
Sbjct: 493 EDTIQGSPLSTYVSINSDTGVLYALCSFDYEQFRDLQMQVTASDSG-SPPLSSNVSLRLF 551
Query: 1141 XXDVNDNSPK 1150
D NDN+P+
Sbjct: 552 VLDQNDNAPE 561
Score = 57.2 bits (132), Expect = 4e-07
Identities = 63/199 (31%), Positives = 93/199 (46%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN GT+I + A D DS N ++ Y +E I S LS Y IN G
Sbjct: 461 LPENNARGTSIFSVIAYDPDSNENSRVIYSL-AEDTIQGSPLST-------YVSINSDTG 512
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK----KTWYN 1051
+ S E + ++ ++A D G+ L+ N+S+R+FV D ND+ P T +
Sbjct: 513 VLYALCSFDYEQFRDLQMQVTASDSGSPPLSSNVSLRLFVLDQNDNAPEILYPALPTDGS 572
Query: 1052 FNVEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG-VLSVNGE 1107
VE A + ++ KV A D D GQNA L+Y + + F + TG V +
Sbjct: 573 TGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLFKASEPGLFSVGLHTGEVRTARAL 632
Query: 1108 LDRETEDKYILTVVARDNG 1126
LDR+ K L V +D+G
Sbjct: 633 LDRDAL-KQSLVVAVQDHG 650
Score = 56.0 bits (129), Expect = 1e-06
Identities = 43/176 (24%), Positives = 77/176 (43%), Gaps = 9/176 (5%)
Query: 220 AIDQDLGVGATLRYELISGNDRK--LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
A D D G+ + Y+ N+++ LF L+ G + K LD + + + + +++Q
Sbjct: 266 ASDLDEGINGKVAYKFWKINEKQSLLFQLNENTGEISTAKSLDYE-----ECSFYEMEIQ 320
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A LK +V I + D+NDN PE + + E+ P G +L A D+D G+
Sbjct: 321 AED-GGGLK-GWTKVLISVEDVNDNRPEVTITSLFSPVREDAPQGTVILLFNAHDRDSGK 378
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
NG+ + + + + + +LDRE S + V A + + T
Sbjct: 379 NGQVVCSIQENLSFTLENSEEDYYRLLTAQILDREKASEYNITVTATDRGTPPLST 434
Score = 52.4 bits (120), Expect = 1e-05
Identities = 34/126 (26%), Positives = 61/126 (48%), Gaps = 9/126 (7%)
Query: 268 QANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQ 327
+A+ + + V A+ P + + + +++ D+NDN P F Y++ + EN G S+
Sbjct: 414 KASEYNITVTATDRGTPPLSTEIHITLQVTDINDNPPAFSQASYSVYLPENNARGTSIFS 473
Query: 328 VMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQT-VL------DREAHSSLRMK 380
V+A D D EN Y L + P S ++++ + T VL D E L+M+
Sbjct: 474 VIAYDPDSNENSRVIYSL--AEDTIQGSPLSTYVSINSDTGVLYALCSFDYEQFRDLQMQ 531
Query: 381 VYAKET 386
V A ++
Sbjct: 532 VTASDS 537
Score = 50.0 bits (114), Expect = 6e-05
Identities = 80/337 (23%), Positives = 132/337 (39%), Gaps = 33/337 (9%)
Query: 59 CDFDEGDDLVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFI 118
C F E + G GL + V + +EDVNDN P T V E P G +
Sbjct: 312 CSFYEMEIQAEDGGGLK---GWTKVLISVEDVNDNRPEVTITSLFSPVREDAPQGTVILL 368
Query: 119 FLI--APIGPSLTIPLTVPRGLTIFKDIRAFDRDKPNTPN-----SDVHYSI-VSGNDDG 170
F G + + ++ L+ + D + T Y+I V+ D G
Sbjct: 369 FNAHDRDSGKNGQVVCSIQENLSFTLENSEEDYYRLLTAQILDREKASEYNITVTATDRG 428
Query: 171 HFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGAT 230
L + L + + D + + +F + A D D +
Sbjct: 429 TPPLSTEIHITLQVTDINDNPPAFSQASYSVYLPENNARGTSIFS--VIAYDPDSNENSR 486
Query: 231 LRYEL----ISGNDRKLF-SLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPL 285
+ Y L I G+ + S++S G L+ D + +LQ +QV AS +P
Sbjct: 487 VIYSLAEDTIQGSPLSTYVSINSDTGVLYALCSFDYEQFRDLQ-----MQVTASDSGSPP 541
Query: 286 KTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLPN----GFSVLQVMATDKDQGEN 338
++ + + +LD NDN PE + + VE P G+ V +V+A D+D G+N
Sbjct: 542 LSSNVSLRLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQN 601
Query: 339 GEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREA 373
+Y+L G FS+ +G + + +LDR+A
Sbjct: 602 AWLSYRLFKASEPGLFSVGLHTGEVRTA-RALLDRDA 637
Score = 42.3 bits (95), Expect = 0.013
Identities = 37/131 (28%), Positives = 60/131 (45%), Gaps = 5/131 (3%)
Query: 229 ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTA 288
A R ++S +LFSL+ +G+L +D + L A + V L +
Sbjct: 60 AERRVRIVSRGRTQLFSLNPRSGTLVTAGRIDRE---ELCAQSPRCLVNFKVLVED-RVK 115
Query: 289 QARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDP 348
+EIE+ D+ND+ P+F+ + + I E G A D D G N +YQL P
Sbjct: 116 LYGIEIEVTDINDSAPKFQAESLEVKINEIAVPGARYPLPEAIDPDVGVNSLQSYQL-SP 174
Query: 349 KGAFSIDPRSG 359
FS++ ++G
Sbjct: 175 NHHFSLNVQTG 185
Score = 41.5 bits (93), Expect = 0.022
Identities = 45/156 (28%), Positives = 68/156 (43%), Gaps = 27/156 (17%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P SST + VTV D D PVF R Y +++ ENV L++ ++ E
Sbjct: 218 GEPRRSSTVRIHVTVLDTNDNA-----PVFAQRIYRVKVLENVPPGTWLLTATASDLDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
N K+ Y N+ F ++ G + +S D E YE+ ++AE
Sbjct: 273 INGKVAYKFWKINEKQ-SLLFQLNENTGEISTAKSLDYEECSFYEMEIQAE--------- 322
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
L+G T KV++ ++DVNDN P+ T
Sbjct: 323 ------DGGGLKGWT----KVLISVEDVNDNRPEVT 348
Score = 38.3 bits (85), Expect = 0.21
Identities = 38/125 (30%), Positives = 58/125 (46%), Gaps = 13/125 (10%)
Query: 439 LMSFVNVEVTLLDANDNNP-VFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPDLGQ 491
L S V++ + +LD NDN P + P S E + +S A+ G ++ KV AVD D GQ
Sbjct: 542 LSSNVSLRLFVLDQNDNAPEILYPALPTDGSTGVELAPRS-AEPGYLVTKVVAVDRDSGQ 600
Query: 492 NGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERR 549
N + Y L + S + F + +TG V A + + + +L V D P
Sbjct: 601 NAWLSYRLFKASEPGL---FSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSAT 657
Query: 550 YSLAV 554
+L V
Sbjct: 658 VTLTV 662
>AF152329-1|AAD43723.1| 932|Homo sapiens protocadherin gamma A9
protein.
Length = 932
Score = 109 bits (261), Expect = 1e-22
Identities = 126/479 (26%), Positives = 207/479 (43%), Gaps = 39/479 (8%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
N + E + +E+ + D ND+ P F +L E + A G +A+DPD+G
Sbjct: 105 NFKVLVEDRVKLYGIEIEVTDINDSAPKFQAESL-EVKINEIAVPGARYPLPEAIDPDVG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR---HALFVEASDQPANPSE 547
N + Y L + ++ N V E + H L + ASD E
Sbjct: 164 VNSLQSYQLSPNHHFSLNVQTGDNGAINPELVLERALDREEATAHHLVLTASDG----GE 219
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QND 605
R S + V I VT + P F Y V NV GT + +D E
Sbjct: 220 PRRS-STVRIHVT--VLDTNDNAPVFAQRIYRVKVLENVPPGTWLLTATASDLDEGINGK 276
Query: 606 VSYDLLHGYE-EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
V+Y E + + F + E +G I+ L Y+ E A ++ L T +
Sbjct: 277 VAYKFWKINEKQSLLFQLNENTGEISTAKSLDYEECSFYEMEIQA-EDGGGLKGWTKVLI 335
Query: 665 HVVDVNDERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
V DVND R V + SP V+E++ + +F+ + NG + + + Q
Sbjct: 336 SVEDVNDNRPEVTITSLFSP----VREDAPQGTVILLFNAHDRDSGKNG----QVVCSIQ 387
Query: 724 QDVTDDIAIAEDG--TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
++++ + +E+ + T + LDREK Y +TV A ++G + +T+ + D N
Sbjct: 388 ENLSFTLENSEEDYYRLLTAQILDREKASEYNITVTAT-DRGTPPLSTEIHITLQVTDIN 446
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEM-- 836
DNPP F A+Y ++ EN+ GT I + A D D N+ +Y+L +G +
Sbjct: 447 DNPPAFSQASYSVYLPENNARGTSIFS---VIAYDPDSNENSRVIYSLAEDTIQGSPLST 503
Query: 837 -FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
++ +TGV+ + S D E+ ++ + A D+G LSS L + + D+NDN PE
Sbjct: 504 YVSINSDTGVL-YALCSFDYEQFRDLQMQVTASDSGSPPLSSNVSLRLFVLDQNDNAPE 561
Score = 85.8 bits (203), Expect = 1e-15
Identities = 111/420 (26%), Positives = 171/420 (40%), Gaps = 53/420 (12%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
GT+ T +DRE+ + F V +Y + I + D ND+ P F+ + E
Sbjct: 82 GTLVTAGRIDREELCAQSPRCLVNFKVLVEDRVKLYGIEIEVTDINDSAPKFQAESLEVK 141
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
I E + G + +A D D G N+L Y L F ++ TG I L
Sbjct: 142 INEIAVPGARYPLP---EAIDPDVGVNSLQSYQL--SPNHHFSLNVQTGDNGAINPELVL 196
Query: 856 EKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAG 915
E+ + R+ ++ L++ D + + +S VRIH
Sbjct: 197 ERAL-------DREE---ATAHHLVLTASDGGEPR-------RSSTVRIH---------- 229
Query: 916 FTIIEVKPKNK-FALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEV 974
T+++ FA + ++ L EN+P GT ++ A DLD G+NG++ Y+F
Sbjct: 230 VTVLDTNDNAPVFAQRIYRVKVL----ENVPPGTWLLTATASDLDEGINGKVAYKF---- 281
Query: 975 YIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDNISVR 1032
K++ + F +NE G + A+SL E S + + I A DGG L V
Sbjct: 282 ----WKINE---KQSLLFQLNENTGEISTAKSLDYEECSFYEMEIQAEDGGGLKGWTKVL 334
Query: 1033 VFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP 1092
+ V+DVND+ P T V E V+ +A D D G+N + IQ +
Sbjct: 335 ISVEDVNDNRPEVTITSLFSPVREDAPQGTVILLFNAHDRDSGKNGQVVCSIQ-ENLSFT 393
Query: 1093 FEISPLTGVLSVNGE-LDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
E S + + LDRE +Y +TV A D G D+NDN P F
Sbjct: 394 LENSEEDYYRLLTAQILDREKASEYNITVTATDRG-TPPLSTEIHITLQVTDINDNPPAF 452
Score = 77.0 bits (181), Expect = 5e-13
Identities = 110/463 (23%), Positives = 194/463 (41%), Gaps = 38/463 (8%)
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
S V + VT+LD NDN PVF +Y + N GT + A D D G NG V Y
Sbjct: 224 STVRIHVTVLDTNDNAPVFA-QRIYRVKVLENVPPGTWLLTATASDLDEGINGKVAYKFW 282
Query: 501 RTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERR-YSLAVVTIEV 559
+ N + F++N NTG +S A+S L+ F E Q + + ++ ++++E
Sbjct: 283 KI-NEKQSLLFQLNENTGEISTAKS--LDYEECSFYEMEIQAEDGGGLKGWTKVLISVE- 338
Query: 560 TRGTKGNKPDIP-DFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGV 618
N+P++ + +P V + GT + +D + + ++ +E +
Sbjct: 339 --DVNDNRPEVTITSLFSP----VREDAPQGTVILLFNAHD--RDSGKNGQVVCSIQENL 390
Query: 619 PFAVE---ERSGVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDERG 674
F +E E + L R Y+ A LS + T+ V D+ND
Sbjct: 391 SFTLENSEEDYYRLLTAQILDREKASEYNITVTATDRGTPPLSTEIHITLQVTDINDNPP 450
Query: 675 VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ----QDVTDDI 730
+ ++S ++ + N+ G +I + + S N V + +A ++ +
Sbjct: 451 AFSQASYS--VYLPENNARGTSIFSVIAYDPDS---NENSRVIYSLAEDTIQGSPLSTYV 505
Query: 731 AIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP--VF 787
+I D G ++ D E+ +M V A + G + + +++ D+NDN P ++
Sbjct: 506 SINSDTGVLYALCSFDYEQFRDLQMQVTAS-DSGSPPLSSNVSLRLFVLDQNDNAPEILY 564
Query: 788 EHATYEGFI-MENSKIGTEIK-MDNIIKATDADEGTNALFMYTLFGEGKE-MFDVDENTG 844
+G +E + E + + A D D G NA Y LF + +F V +TG
Sbjct: 565 PALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLFKASEPGLFSVGLHTG 624
Query: 845 VVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
V+ LDR+ + L + +D G LS+ L + I D
Sbjct: 625 EVRTARALLDRD-ALKQSLVVAVQDHGQPPLSATVTLTVAIAD 666
Score = 72.5 bits (170), Expect = 1e-11
Identities = 49/176 (27%), Positives = 85/176 (48%), Gaps = 8/176 (4%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV 273
+P P AID D+GV + Y+L + L NG++ E L+ + +A
Sbjct: 152 YPLP-EAIDPDVGVNSLQSYQLSPNHHFSLNVQTGDNGAINPELVLERALDRE-EATAHH 209
Query: 274 LQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDK 333
L + AS P +++ R+ + +LD NDN P F Y + ++EN+P G +L A+D
Sbjct: 210 LVLTASDGGEPRRSSTVRIHVTVLDTNDNAPVFAQRIYRVKVLENVPPGTWLLTATASDL 269
Query: 334 DQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D+G NG+ Y+ + F ++ +G ++ LD E S M++ A++
Sbjct: 270 DEGINGKVAYKFWKINEKQSLLFQLNENTGEISTAKS--LDYEECSFYEMEIQAED 323
Score = 68.1 bits (159), Expect = 2e-10
Identities = 57/190 (30%), Positives = 84/190 (44%), Gaps = 11/190 (5%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I T K LD E+ Y M + AE G+ G +V I +ED NDN P +
Sbjct: 299 GEISTAKSLDYEECSFYEMEIQAEDGGGL---KGWTKVLISVEDVNDNRPEVTITSLFSP 355
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
+ E++ GT I + N A D D G N + ++ + E LDR
Sbjct: 356 VREDAPQGTVILLFN---AHDRDSGKNGQVVCSIQENLSFTLENSEEDYYRLLTAQILDR 412
Query: 856 EKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
EK Y +++ A D G LS+E + + + D NDN P F+Q + + E GT
Sbjct: 413 EKASEYNITVTATDRGTPPLSTEIHITLQVTDINDNPPAFSQASYSVYL---PENNARGT 469
Query: 914 AGFTIIEVKP 923
+ F++I P
Sbjct: 470 SIFSVIAYDP 479
Score = 58.0 bits (134), Expect = 2e-07
Identities = 66/250 (26%), Positives = 100/250 (40%), Gaps = 25/250 (10%)
Query: 912 GTAGFT--IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
G G+T +I V+ N +V + E+ P GT I+ NA D DSG NGQ+
Sbjct: 326 GLKGWTKVLISVEDVNDNRPEVTITSLFSPVREDAPQGTVILLFNAHDRDSGKNGQVVCS 385
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN--L 1025
+ D Y+ ++ A+ L E SE+ + ++A D G L
Sbjct: 386 IQENLSFTLENSEED------YY-------RLLTAQILDREKASEYNITVTATDRGTPPL 432
Query: 1026 NDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY--- 1082
+ I + + V D+ND+ P F + Y+ + E + V A D D +N+ + Y
Sbjct: 433 STEIHITLQVTDINDNPPAFSQASYSVYLPENNARGTSIFSVIAYDPDSNENSRVIYSLA 492
Query: 1083 --FIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXX 1140
IQ S I+ TGVL D E + V A D+G
Sbjct: 493 EDTIQGSPLSTYVSINSDTGVLYALCSFDYEQFRDLQMQVTASDSG-SPPLSSNVSLRLF 551
Query: 1141 XXDVNDNSPK 1150
D NDN+P+
Sbjct: 552 VLDQNDNAPE 561
Score = 57.2 bits (132), Expect = 4e-07
Identities = 63/199 (31%), Positives = 93/199 (46%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN GT+I + A D DS N ++ Y +E I S LS Y IN G
Sbjct: 461 LPENNARGTSIFSVIAYDPDSNENSRVIYSL-AEDTIQGSPLST-------YVSINSDTG 512
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK----KTWYN 1051
+ S E + ++ ++A D G+ L+ N+S+R+FV D ND+ P T +
Sbjct: 513 VLYALCSFDYEQFRDLQMQVTASDSGSPPLSSNVSLRLFVLDQNDNAPEILYPALPTDGS 572
Query: 1052 FNVEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG-VLSVNGE 1107
VE A + ++ KV A D D GQNA L+Y + + F + TG V +
Sbjct: 573 TGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLFKASEPGLFSVGLHTGEVRTARAL 632
Query: 1108 LDRETEDKYILTVVARDNG 1126
LDR+ K L V +D+G
Sbjct: 633 LDRDAL-KQSLVVAVQDHG 650
Score = 56.0 bits (129), Expect = 1e-06
Identities = 43/176 (24%), Positives = 77/176 (43%), Gaps = 9/176 (5%)
Query: 220 AIDQDLGVGATLRYELISGNDRK--LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
A D D G+ + Y+ N+++ LF L+ G + K LD + + + + +++Q
Sbjct: 266 ASDLDEGINGKVAYKFWKINEKQSLLFQLNENTGEISTAKSLDYE-----ECSFYEMEIQ 320
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A LK +V I + D+NDN PE + + E+ P G +L A D+D G+
Sbjct: 321 AED-GGGLK-GWTKVLISVEDVNDNRPEVTITSLFSPVREDAPQGTVILLFNAHDRDSGK 378
Query: 338 NGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
NG+ + + + + + +LDRE S + V A + + T
Sbjct: 379 NGQVVCSIQENLSFTLENSEEDYYRLLTAQILDREKASEYNITVTATDRGTPPLST 434
Score = 52.4 bits (120), Expect = 1e-05
Identities = 34/126 (26%), Positives = 61/126 (48%), Gaps = 9/126 (7%)
Query: 268 QANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQ 327
+A+ + + V A+ P + + + +++ D+NDN P F Y++ + EN G S+
Sbjct: 414 KASEYNITVTATDRGTPPLSTEIHITLQVTDINDNPPAFSQASYSVYLPENNARGTSIFS 473
Query: 328 VMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQT-VL------DREAHSSLRMK 380
V+A D D EN Y L + P S ++++ + T VL D E L+M+
Sbjct: 474 VIAYDPDSNENSRVIYSL--AEDTIQGSPLSTYVSINSDTGVLYALCSFDYEQFRDLQMQ 531
Query: 381 VYAKET 386
V A ++
Sbjct: 532 VTASDS 537
Score = 50.0 bits (114), Expect = 6e-05
Identities = 80/337 (23%), Positives = 132/337 (39%), Gaps = 33/337 (9%)
Query: 59 CDFDEGDDLVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFI 118
C F E + G GL + V + +EDVNDN P T V E P G +
Sbjct: 312 CSFYEMEIQAEDGGGLK---GWTKVLISVEDVNDNRPEVTITSLFSPVREDAPQGTVILL 368
Query: 119 FLI--APIGPSLTIPLTVPRGLTIFKDIRAFDRDKPNTPN-----SDVHYSI-VSGNDDG 170
F G + + ++ L+ + D + T Y+I V+ D G
Sbjct: 369 FNAHDRDSGKNGQVVCSIQENLSFTLENSEEDYYRLLTAQILDREKASEYNITVTATDRG 428
Query: 171 HFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGAT 230
L + L + + D + + +F + A D D +
Sbjct: 429 TPPLSTEIHITLQVTDINDNPPAFSQASYSVYLPENNARGTSIFS--VIAYDPDSNENSR 486
Query: 231 LRYEL----ISGNDRKLF-SLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPL 285
+ Y L I G+ + S++S G L+ D + +LQ +QV AS +P
Sbjct: 487 VIYSLAEDTIQGSPLSTYVSINSDTGVLYALCSFDYEQFRDLQ-----MQVTASDSGSPP 541
Query: 286 KTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLPN----GFSVLQVMATDKDQGEN 338
++ + + +LD NDN PE + + VE P G+ V +V+A D+D G+N
Sbjct: 542 LSSNVSLRLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQN 601
Query: 339 GEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREA 373
+Y+L G FS+ +G + + +LDR+A
Sbjct: 602 AWLSYRLFKASEPGLFSVGLHTGEVRTA-RALLDRDA 637
Score = 42.3 bits (95), Expect = 0.013
Identities = 37/131 (28%), Positives = 60/131 (45%), Gaps = 5/131 (3%)
Query: 229 ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTA 288
A R ++S +LFSL+ +G+L +D + L A + V L +
Sbjct: 60 AERRVRIVSRGRTQLFSLNPRSGTLVTAGRIDRE---ELCAQSPRCLVNFKVLVED-RVK 115
Query: 289 QARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDP 348
+EIE+ D+ND+ P+F+ + + I E G A D D G N +YQL P
Sbjct: 116 LYGIEIEVTDINDSAPKFQAESLEVKINEIAVPGARYPLPEAIDPDVGVNSLQSYQL-SP 174
Query: 349 KGAFSIDPRSG 359
FS++ ++G
Sbjct: 175 NHHFSLNVQTG 185
Score = 41.5 bits (93), Expect = 0.022
Identities = 45/156 (28%), Positives = 68/156 (43%), Gaps = 27/156 (17%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P SST + VTV D D PVF R Y +++ ENV L++ ++ E
Sbjct: 218 GEPRRSSTVRIHVTVLDTNDNA-----PVFAQRIYRVKVLENVPPGTWLLTATASDLDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
N K+ Y N+ F ++ G + +S D E YE+ ++AE
Sbjct: 273 INGKVAYKFWKINEKQ-SLLFQLNENTGEISTAKSLDYEECSFYEMEIQAE--------- 322
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
L+G T KV++ ++DVNDN P+ T
Sbjct: 323 ------DGGGLKGWT----KVLISVEDVNDNRPEVT 348
Score = 38.3 bits (85), Expect = 0.21
Identities = 38/125 (30%), Positives = 58/125 (46%), Gaps = 13/125 (10%)
Query: 439 LMSFVNVEVTLLDANDNNP-VFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPDLGQ 491
L S V++ + +LD NDN P + P S E + +S A+ G ++ KV AVD D GQ
Sbjct: 542 LSSNVSLRLFVLDQNDNAPEILYPALPTDGSTGVELAPRS-AEPGYLVTKVVAVDRDSGQ 600
Query: 492 NGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERR 549
N + Y L + S + F + +TG V A + + + +L V D P
Sbjct: 601 NAWLSYRLFKASEPGL---FSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSAT 657
Query: 550 YSLAV 554
+L V
Sbjct: 658 VTLTV 662
>BC112098-1|AAI12099.1| 818|Homo sapiens protocadherin beta 1,
precursor protein.
Length = 818
Score = 107 bits (257), Expect = 3e-22
Identities = 129/495 (26%), Positives = 200/495 (40%), Gaps = 58/495 (11%)
Query: 936 PLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVIN 995
PL IPE+ P+G+ +A DLD GLNG Y ++ Y R+
Sbjct: 138 PLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNYTLSANGYFHLHT---------RFCSHG 188
Query: 996 ERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYN 1051
++ +++ + L E E L I+A+DGG+ + + V V DVNDH P F + Y
Sbjct: 189 PKYAELVLNKPLDREEQPEVNLTITAVDGGSPPKSGTAHIHVVVLDVNDHVPQFSRLVYR 248
Query: 1052 FNVEEAQYTRRVLGKVDATDADFGQNANLTYFI--QPSDTDLPFEISPLTGVLSVNGELD 1109
V E ++ V A D D G N +TY + P F+I P G + + G LD
Sbjct: 249 AQVSENSPNGSLVATVTAVDLDEGTNKAITYSLAQNPEAILKTFQIDPQNGEVRLRGPLD 308
Query: 1110 RETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY---AFDELLEWKHPE-A 1165
E + Y + + A D G DVNDN P+ L E P+
Sbjct: 309 FEAIETYDIDIQATDGG---GLSAHSKVLVEVVDVNDNPPEVMVSSVSSPLPEDSPPQTV 365
Query: 1166 DELSNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQRKN 1223
L + + + E+ P I T ++ TD + + Y++
Sbjct: 366 VALFTIRDRDIRVGGKVTCFLREDLPFVIKPTFGNSYSLVTDRSLDREEVSGYNI--TIV 423
Query: 1224 QQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTE 1283
+ G PSLS+ ++ V ++DV D + P+F Y L + EN N+P + E
Sbjct: 424 AMDTGPPSLSAETMIEVLISDVND-----NPPIFREDSYILTVREN-NSPAVFIGKVHAE 477
Query: 1284 HY---ENFKMRYYIL--NENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
EN ++ Y +L D + I+ NG LY +R+ D E ++ +V+A
Sbjct: 478 DLDLGENAQITYSLLPPKNGDLSVFAYISINSGNGKLYALRTMDYEAIQDFQFVVKATDG 537
Query: 1339 KYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTNGNRPLVTAIPTT 1394
+ L ++ V+VVV D NDN P NG P +P +
Sbjct: 538 GF---------------LSLSSQVTVRVVV--LDDNDNRPMILYPLQNGTLPCNDLVPRS 580
Query: 1395 APFGYQVMQLKGAIG 1409
A GY V ++ G
Sbjct: 581 AEAGYLVTKVVAVDG 595
Score = 96.7 bits (230), Expect = 6e-19
Identities = 119/499 (23%), Positives = 198/499 (39%), Gaps = 34/499 (6%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E L SF EV + D NDN PVF+ + + +G+ A D D+G NG+
Sbjct: 112 EPLQSF-RAEVRVFDINDNAPVFLNKEPL-LKIPESTPLGSRFPLQSAQDLDVGLNGLQN 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHA---LFVEASDQPANPSERRYSLA 553
Y L + + F + V P+ L + A D + P +
Sbjct: 170 YTLSANGYFHLHTRFCSHGPKYAELVLNKPLDREEQPEVNLTITAVDGGSPPKSGTAHIH 229
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND--VSYDLL 611
VV ++V +P F Y V N G+ V + D E + ++Y L
Sbjct: 230 VVVLDVN-------DHVPQFSRLVYRAQVSENSPNGSLVATVTAVDLDEGTNKAITYSLA 282
Query: 612 HGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
E + F ++ ++G + + L YD + A + LS + V VVDVN
Sbjct: 283 QNPEAILKTFQIDPQNGEVRLRGPLDFEAIETYDIDIQAT-DGGGLSAHSKVLVEVVDVN 341
Query: 671 DERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D V++ SP+ E+S + +F I G V +
Sbjct: 342 DNPPEVMVSSVSSPL----PEDSPPQTVVALFTIRDRDIRVGG--KVTCFLREDLPFVIK 395
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
++ T + LDRE+ Y +T++A + G S + + + I D NDNPP+F
Sbjct: 396 PTFGNSYSLVTDRSLDREEVSGYNITIVA-MDTGPPSLSAETMIEVLISDVNDNPPIFRE 454
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF----GEGKEMFDVDENTGV 845
+Y + EN+ I + A D D G NA Y+L G+ + N+G
Sbjct: 455 DSYILTVRENNSPAVFI---GKVHAEDLDLGENAQITYSLLPPKNGDLSVFAYISINSGN 511
Query: 846 VKFIG-DSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKV 902
K ++D E ++ + A D G LSS+ + +++ D+NDN+P +N +
Sbjct: 512 GKLYALRTMDYEAIQDFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQNGTL 571
Query: 903 RIHRETKLNGTAGFTIIEV 921
+ + AG+ + +V
Sbjct: 572 PCNDLVPRSAEAGYLVTKV 590
Score = 72.9 bits (171), Expect = 8e-12
Identities = 104/458 (22%), Positives = 190/458 (41%), Gaps = 35/458 (7%)
Query: 444 NVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTS 503
++ V +LD ND+ P F +Y + N+ G+++ V AVD D G N + Y L +
Sbjct: 227 HIHVVVLDVNDHVPQF-SRLVYRAQVSENSPNGSLVATVTAVDLDEGTNKAITYSLAQNP 285
Query: 504 NLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAVVTIEVTR 561
I F+I+P G V + E + + ++A+D + + + VV +
Sbjct: 286 E-AILKTFQIDPQNGEVRLRGPLDFEAIETYDIDIQATDGGGLSAHSKVLVEVVDVN--- 341
Query: 562 GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFA 621
+ P P+ M + + + T V + D V + E +PF
Sbjct: 342 ----DNP--PEVMVSSVSSPLPEDSPPQTVVALFTIRD--RDIRVGGKVTCFLREDLPFV 393
Query: 622 VEERSG-VITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLL 677
++ G ++V D L R Y+ VA+ +LS T V + DVND +
Sbjct: 394 IKPTFGNSYSLVTDRSLDREEVSGYNITIVAMDTGPPSLSAETMIEVLISDVNDNPPIFR 453
Query: 678 KGAHSPIIFHVKENSAGAA-IGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIA--- 733
+ ++ I V+EN++ A IG++ H + N L D++ I+
Sbjct: 454 EDSY---ILTVRENNSPAVFIGKV-HAEDLDLGENAQITYSLLPPKNGDLSVFAYISINS 509
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
+G ++ + +D E ++ V A + G +S + V + + D+NDN P+ +
Sbjct: 510 GNGKLYALRTMDYEAIQDFQFVVKAT-DGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQN 568
Query: 794 GFIMENSKIGTEIKMDNIIK---ATDADEGTNALFMYTLF-GEGKEMFDVDENTGVVKFI 849
G + N + + ++ A D D G N+ Y L +F V G + +
Sbjct: 569 GTLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLLKATDLGLFSVQRQNGEIHTL 628
Query: 850 GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
+R+ +M KL ++ +D G LS+ L I++ D
Sbjct: 629 RQISERD-PMMQKLIILVQDHGQPALSTTVSLNILLVD 665
Score = 71.7 bits (168), Expect = 2e-11
Identities = 54/172 (31%), Positives = 83/172 (48%), Gaps = 11/172 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELD--LDAEHNLQANTFVLQVQ 277
A D D+G+ Y L + L + +G + E L+ LD E + N L +
Sbjct: 157 AQDLDVGLNGLQNYTLSANGYFHLHTRFCSHGPKYAELVLNKPLDREEQPEVN---LTIT 213
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A +P K+ A + + +LD+ND++P+F Y + EN PNG V V A D D+G
Sbjct: 214 AVDGGSPPKSGTAHIHVVVLDVNDHVPQFSRLVYRAQVSENSPNGSLVATVTAVDLDEGT 273
Query: 338 NGEFTYQL-DDPKG---AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N TY L +P+ F IDP++G VR + LD EA + + + A +
Sbjct: 274 NKAITYSLAQNPEAILKTFQIDPQNG--EVRLRGPLDFEAIETYDIDIQATD 323
Score = 60.5 bits (140), Expect = 5e-08
Identities = 90/354 (25%), Positives = 154/354 (43%), Gaps = 33/354 (9%)
Query: 32 VSVILAQSIDSLVDSDS--PQN-VVKFRLGCDFD--EGDDLVRIGAGLNQISAYLSVTVY 86
++ LAQ+ ++++ + PQN V+ R DF+ E D+ +SA+ V V
Sbjct: 277 ITYSLAQNPEAILKTFQIDPQNGEVRLRGPLDFEAIETYDIDIQATDGGGLSAHSKVLVE 336
Query: 87 IEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP----IGPSLTIPLTVPRGLTI-- 140
+ DVNDN P + + + E +P +F I +G +T L I
Sbjct: 337 VVDVNDNPPEVMVSSVSSPLPEDSPPQTVVALFTIRDRDIRVGGKVTCFLREDLPFVIKP 396
Query: 141 -FKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQ 198
F + + D+ Y+I + D G +L + +L+ V D +E
Sbjct: 397 TFGNSYSLVTDRSLDREEVSGYNITIVAMDTGPPSLSAETMIEVLISDVNDNPPIFREDS 456
Query: 199 LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELI--SGNDRKLF---SLDSVNGSL 253
++ + + +F +HA D DLG A + Y L+ D +F S++S NG L
Sbjct: 457 YILTV--RENNSPAVFIGKVHAEDLDLGENAQITYSLLPPKNGDLSVFAYISINSGNGKL 514
Query: 254 FLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNI 313
+ + +D +A + Q FV V+A+ ++Q V + +LD NDN P N
Sbjct: 515 YALRTMDYEAIQDFQ---FV--VKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQNG 569
Query: 314 SIVEN--LPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSG 359
++ N +P G+ V +V+A D D G+N +Y L G FS+ ++G
Sbjct: 570 TLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLLKATDLGLFSVQRQNG 623
Score = 59.7 bits (138), Expect = 8e-08
Identities = 58/201 (28%), Positives = 93/201 (46%), Gaps = 20/201 (9%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
+ + EN I K++A DLD G N QI Y +PP + D L V Y IN
Sbjct: 458 ILTVRENNSPAVFIGKVHAEDLDLGENAQITYSL-----LPPK--NGD-LSVFAYISINS 509
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+G + R++ E+ +F+ + A DGG +L+ ++VRV V D ND+ P+ N
Sbjct: 510 GNGKLYALRTMDYEAIQDFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQNG 569
Query: 1053 N------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP-FEISPLTGVLSVN 1105
V + ++ KV A D D GQN+ L+Y + + TDL F + G +
Sbjct: 570 TLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLLKA-TDLGLFSVQRQNGEIHTL 628
Query: 1106 GELDRETEDKYILTVVARDNG 1126
++ L ++ +D+G
Sbjct: 629 RQISERDPMMQKLIILVQDHG 649
Score = 55.2 bits (127), Expect = 2e-06
Identities = 48/174 (27%), Positives = 77/174 (44%), Gaps = 11/174 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR--KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A+D D G + Y L + K F +D NG + L LD +A T+ +
Sbjct: 264 VTAVDLDEGTNKAITYSLAQNPEAILKTFQIDPQNGEVRLRGPLDFEA-----IETYDID 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
+QA+ +A ++V +E++D+NDN PE V + + E+ P V D+D
Sbjct: 319 IQATDGGG--LSAHSKVLVEVVDVNDNPPEVMVSSVSSPLPEDSPPQTVVALFTIRDRDI 376
Query: 336 GENGEFTYQLDDPKGAFSIDPRSG-WLTVRNQTVLDREAHSSLRMKVYAKETNP 388
G+ T L + F I P G ++ LDRE S + + A +T P
Sbjct: 377 RVGGKVTCFLREDL-PFVIKPTFGNSYSLVTDRSLDREEVSGYNITIVAMDTGP 429
Score = 44.0 bits (99), Expect = 0.004
Identities = 40/134 (29%), Positives = 63/134 (47%), Gaps = 5/134 (3%)
Query: 224 DLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNN 283
++G A L+S ++ F L G LF++++LD ++ +A+ VL + L
Sbjct: 55 EVGKLAARGARLVSEGNKMHFRLHRKTGDLFVKEKLDRESLCG-KADPCVLHFEVV-LVE 112
Query: 284 PLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTY 343
PL++ +A E+ + D+NDN P F + I E+ P G A D D G NG Y
Sbjct: 113 PLQSFRA--EVRVFDINDNAPVFLNKEPLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNY 170
Query: 344 QLDDPKGAFSIDPR 357
L G F + R
Sbjct: 171 TL-SANGYFHLHTR 183
>BC112096-1|AAI12097.1| 818|Homo sapiens protocadherin beta 1,
precursor protein.
Length = 818
Score = 107 bits (257), Expect = 3e-22
Identities = 129/495 (26%), Positives = 200/495 (40%), Gaps = 58/495 (11%)
Query: 936 PLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVIN 995
PL IPE+ P+G+ +A DLD GLNG Y ++ Y R+
Sbjct: 138 PLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNYTLSANGYFHLHT---------RFCSHG 188
Query: 996 ERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYN 1051
++ +++ + L E E L I+A+DGG+ + + V V DVNDH P F + Y
Sbjct: 189 PKYAELVLNKPLDREEQPEVNLTITAVDGGSPPKSGTAHIHVVVLDVNDHVPQFSRLVYR 248
Query: 1052 FNVEEAQYTRRVLGKVDATDADFGQNANLTYFI--QPSDTDLPFEISPLTGVLSVNGELD 1109
V E ++ V A D D G N +TY + P F+I P G + + G LD
Sbjct: 249 AQVSENSPNGSLVATVTAVDLDEGTNKAITYSLAQNPEAILKTFQIDPQNGEVRLRGPLD 308
Query: 1110 RETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY---AFDELLEWKHPE-A 1165
E + Y + + A D G DVNDN P+ L E P+
Sbjct: 309 FEAIETYDIDIQATDGG---GLSAHSKVLVEVVDVNDNPPEVMVSSVSSPLPEDSPPQTV 365
Query: 1166 DELSNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQRKN 1223
L + + + E+ P I T ++ TD + + Y++
Sbjct: 366 VALFTIRDRDIRVGGKVTCFLREDLPFVIKPTFGNSYSLVTDRSLDREEVSGYNI--TIV 423
Query: 1224 QQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTE 1283
+ G PSLS+ ++ V ++DV D + P+F Y L + EN N+P + E
Sbjct: 424 AMDTGPPSLSAETMIEVLISDVND-----NPPIFREDSYILTVREN-NSPAVFIGKVHAE 477
Query: 1284 HY---ENFKMRYYIL--NENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
EN ++ Y +L D + I+ NG LY +R+ D E ++ +V+A
Sbjct: 478 DLDLGENAQITYSLLPPKNGDLSVFAYISINSGNGKLYALRTMDYEAIQDFQFVVKATDG 537
Query: 1339 KYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTNGNRPLVTAIPTT 1394
+ L ++ V+VVV D NDN P NG P +P +
Sbjct: 538 GF---------------LSLSSQVTVRVVV--LDDNDNRPMILYPLQNGTLPCNDLVPRS 580
Query: 1395 APFGYQVMQLKGAIG 1409
A GY V ++ G
Sbjct: 581 AEAGYLVTKVVAVDG 595
Score = 96.7 bits (230), Expect = 6e-19
Identities = 119/499 (23%), Positives = 198/499 (39%), Gaps = 34/499 (6%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E L SF EV + D NDN PVF+ + + +G+ A D D+G NG+
Sbjct: 112 EPLQSF-RAEVRVFDINDNAPVFLNKEPL-LKIPESTPLGSRFPLQSAQDLDVGLNGLQN 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHA---LFVEASDQPANPSERRYSLA 553
Y L + + F + V P+ L + A D + P +
Sbjct: 170 YTLSANGYFHLHTRFCSHGPKYAELVLNKPLDREEQPEVNLTITAVDGGSPPKSGTAHIH 229
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND--VSYDLL 611
VV ++V +P F Y V N G+ V + D E + ++Y L
Sbjct: 230 VVVLDVN-------DHVPQFSRLVYRAQVSENSPNGSLVATVTAVDLDEGTNKAITYSLA 282
Query: 612 HGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
E + F ++ ++G + + L YD + A + LS + V VVDVN
Sbjct: 283 QNPEAILKTFQIDPQNGEVRLRGPLDFEAIETYDIDIQAT-DGGGLSAHSKVLVEVVDVN 341
Query: 671 DERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D V++ SP+ E+S + +F I G V +
Sbjct: 342 DNPPEVMVSSVSSPL----PEDSPPQTVVALFTIRDRDIRVGG--KVTCFLREDLPFVIK 395
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
++ T + LDRE+ Y +T++A + G S + + + I D NDNPP+F
Sbjct: 396 PTFGNSYSLVTDRSLDREEVSGYNITIVA-MDTGPPSLSAETMIEVLISDVNDNPPIFRE 454
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF----GEGKEMFDVDENTGV 845
+Y + EN+ I + A D D G NA Y+L G+ + N+G
Sbjct: 455 DSYILTVRENNSPAVFI---GKVHAEDLDLGENAQITYSLLPPKNGDLSVFAYISINSGN 511
Query: 846 VKFIG-DSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKV 902
K ++D E ++ + A D G LSS+ + +++ D+NDN+P +N +
Sbjct: 512 GKLYALRTMDYEAIQDFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQNGTL 571
Query: 903 RIHRETKLNGTAGFTIIEV 921
+ + AG+ + +V
Sbjct: 572 PCNDLVPRSAEAGYLVTKV 590
Score = 72.9 bits (171), Expect = 8e-12
Identities = 104/458 (22%), Positives = 190/458 (41%), Gaps = 35/458 (7%)
Query: 444 NVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTS 503
++ V +LD ND+ P F +Y + N+ G+++ V AVD D G N + Y L +
Sbjct: 227 HIHVVVLDVNDHVPQF-SRLVYRAQVSENSPNGSLVATVTAVDLDEGTNKAITYSLAQNP 285
Query: 504 NLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAVVTIEVTR 561
I F+I+P G V + E + + ++A+D + + + VV +
Sbjct: 286 E-AILKTFQIDPQNGEVRLRGPLDFEAIETYDIDIQATDGGGLSAHSKVLVEVVDVN--- 341
Query: 562 GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFA 621
+ P P+ M + + + T V + D V + E +PF
Sbjct: 342 ----DNP--PEVMVSSVSSPLPEDSPPQTVVALFTIRD--RDIRVGGKVTCFLREDLPFV 393
Query: 622 VEERSG-VITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLL 677
++ G ++V D L R Y+ VA+ +LS T V + DVND +
Sbjct: 394 IKPTFGNSYSLVTDRSLDREEVSGYNITIVAMDTGPPSLSAETMIEVLISDVNDNPPIFR 453
Query: 678 KGAHSPIIFHVKENSAGAA-IGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIA--- 733
+ ++ I V+EN++ A IG++ H + N L D++ I+
Sbjct: 454 EDSY---ILTVRENNSPAVFIGKV-HAEDLDLGENAQITYSLLPPKNGDLSVFAYISINS 509
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
+G ++ + +D E ++ V A + G +S + V + + D+NDN P+ +
Sbjct: 510 GNGKLYALRTMDYEAIQDFQFVVKAT-DGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQN 568
Query: 794 GFIMENSKIGTEIKMDNIIK---ATDADEGTNALFMYTLF-GEGKEMFDVDENTGVVKFI 849
G + N + + ++ A D D G N+ Y L +F V G + +
Sbjct: 569 GTLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLLKATDLGLFSVQRQNGEIHTL 628
Query: 850 GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
+R+ +M KL ++ +D G LS+ L I++ D
Sbjct: 629 RQISERD-PMMQKLIILVQDHGQPALSTTVSLNILLVD 665
Score = 71.7 bits (168), Expect = 2e-11
Identities = 54/172 (31%), Positives = 83/172 (48%), Gaps = 11/172 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELD--LDAEHNLQANTFVLQVQ 277
A D D+G+ Y L + L + +G + E L+ LD E + N L +
Sbjct: 157 AQDLDVGLNGLQNYTLSANGYFHLHTRFCSHGPKYAELVLNKPLDREEQPEVN---LTIT 213
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A +P K+ A + + +LD+ND++P+F Y + EN PNG V V A D D+G
Sbjct: 214 AVDGGSPPKSGTAHIHVVVLDVNDHVPQFSRLVYRAQVSENSPNGSLVATVTAVDLDEGT 273
Query: 338 NGEFTYQL-DDPKG---AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N TY L +P+ F IDP++G VR + LD EA + + + A +
Sbjct: 274 NKAITYSLAQNPEAILKTFQIDPQNG--EVRLRGPLDFEAIETYDIDIQATD 323
Score = 60.5 bits (140), Expect = 5e-08
Identities = 90/354 (25%), Positives = 154/354 (43%), Gaps = 33/354 (9%)
Query: 32 VSVILAQSIDSLVDSDS--PQN-VVKFRLGCDFD--EGDDLVRIGAGLNQISAYLSVTVY 86
++ LAQ+ ++++ + PQN V+ R DF+ E D+ +SA+ V V
Sbjct: 277 ITYSLAQNPEAILKTFQIDPQNGEVRLRGPLDFEAIETYDIDIQATDGGGLSAHSKVLVE 336
Query: 87 IEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP----IGPSLTIPLTVPRGLTI-- 140
+ DVNDN P + + + E +P +F I +G +T L I
Sbjct: 337 VVDVNDNPPEVMVSSVSSPLPEDSPPQTVVALFTIRDRDIRVGGKVTCFLREDLPFVIKP 396
Query: 141 -FKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQ 198
F + + D+ Y+I + D G +L + +L+ V D +E
Sbjct: 397 TFGNSYSLVTDRSLDREEVSGYNITIVAMDTGPPSLSAETMIEVLISDVNDNPPIFREDS 456
Query: 199 LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELI--SGNDRKLF---SLDSVNGSL 253
++ + + +F +HA D DLG A + Y L+ D +F S++S NG L
Sbjct: 457 YILTV--RENNSPAVFIGKVHAEDLDLGENAQITYSLLPPKNGDLSVFAYISINSGNGKL 514
Query: 254 FLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNI 313
+ + +D +A + Q FV V+A+ ++Q V + +LD NDN P N
Sbjct: 515 YALRTMDYEAIQDFQ---FV--VKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQNG 569
Query: 314 SIVEN--LPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSG 359
++ N +P G+ V +V+A D D G+N +Y L G FS+ ++G
Sbjct: 570 TLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLLKATDLGLFSVQRQNG 623
Score = 59.7 bits (138), Expect = 8e-08
Identities = 58/201 (28%), Positives = 93/201 (46%), Gaps = 20/201 (9%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
+ + EN I K++A DLD G N QI Y +PP + D L V Y IN
Sbjct: 458 ILTVRENNSPAVFIGKVHAEDLDLGENAQITYSL-----LPPK--NGD-LSVFAYISINS 509
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+G + R++ E+ +F+ + A DGG +L+ ++VRV V D ND+ P+ N
Sbjct: 510 GNGKLYALRTMDYEAIQDFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQNG 569
Query: 1053 N------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP-FEISPLTGVLSVN 1105
V + ++ KV A D D GQN+ L+Y + + TDL F + G +
Sbjct: 570 TLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLLKA-TDLGLFSVQRQNGEIHTL 628
Query: 1106 GELDRETEDKYILTVVARDNG 1126
++ L ++ +D+G
Sbjct: 629 RQISERDPMMQKLIILVQDHG 649
Score = 55.2 bits (127), Expect = 2e-06
Identities = 48/174 (27%), Positives = 77/174 (44%), Gaps = 11/174 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR--KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A+D D G + Y L + K F +D NG + L LD +A T+ +
Sbjct: 264 VTAVDLDEGTNKAITYSLAQNPEAILKTFQIDPQNGEVRLRGPLDFEA-----IETYDID 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
+QA+ +A ++V +E++D+NDN PE V + + E+ P V D+D
Sbjct: 319 IQATDGGG--LSAHSKVLVEVVDVNDNPPEVMVSSVSSPLPEDSPPQTVVALFTIRDRDI 376
Query: 336 GENGEFTYQLDDPKGAFSIDPRSG-WLTVRNQTVLDREAHSSLRMKVYAKETNP 388
G+ T L + F I P G ++ LDRE S + + A +T P
Sbjct: 377 RVGGKVTCFLREDL-PFVIKPTFGNSYSLVTDRSLDREEVSGYNITIVAMDTGP 429
Score = 44.0 bits (99), Expect = 0.004
Identities = 40/134 (29%), Positives = 63/134 (47%), Gaps = 5/134 (3%)
Query: 224 DLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNN 283
++G A L+S ++ F L G LF++++LD ++ +A+ VL + L
Sbjct: 55 EVGKLAARGARLVSEGNKMHFRLHRKTGDLFVKEKLDRESLCG-KADPCVLHFEVV-LVE 112
Query: 284 PLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTY 343
PL++ +A E+ + D+NDN P F + I E+ P G A D D G NG Y
Sbjct: 113 PLQSFRA--EVRVFDINDNAPVFLNKEPLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNY 170
Query: 344 QLDDPKGAFSIDPR 357
L G F + R
Sbjct: 171 TL-SANGYFHLHTR 183
>AF152488-1|AAD43749.1| 818|Homo sapiens protocadherin beta 1
protein.
Length = 818
Score = 107 bits (257), Expect = 3e-22
Identities = 129/495 (26%), Positives = 200/495 (40%), Gaps = 58/495 (11%)
Query: 936 PLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVIN 995
PL IPE+ P+G+ +A DLD GLNG Y ++ Y R+
Sbjct: 138 PLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNYTLSANGYFHLHT---------RFCSHG 188
Query: 996 ERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYN 1051
++ +++ + L E E L I+A+DGG+ + + V V DVNDH P F + Y
Sbjct: 189 PKYAELVLNKPLDREEQPEVNLTITAVDGGSPPKSGTAHIHVVVLDVNDHVPQFSRLVYR 248
Query: 1052 FNVEEAQYTRRVLGKVDATDADFGQNANLTYFI--QPSDTDLPFEISPLTGVLSVNGELD 1109
V E ++ V A D D G N +TY + P F+I P G + + G LD
Sbjct: 249 AQVSENSPNGSLVATVTAVDLDEGTNKAITYSLAQNPEAILKTFQIDPQNGEVRLRGPLD 308
Query: 1110 RETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY---AFDELLEWKHPE-A 1165
E + Y + + A D G DVNDN P+ L E P+
Sbjct: 309 FEAIETYDIDIQATDGG---GLSAHSKVLVEVVDVNDNPPEVMVSSVSSPLPEDSPPQTV 365
Query: 1166 DELSNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQRKN 1223
L + + + E+ P I T ++ TD + + Y++
Sbjct: 366 VALFTIRDRDIRVGGKVTCFLREDLPFVIKPTFGNSYSLVTDRSLDREEVSGYNI--TIV 423
Query: 1224 QQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTE 1283
+ G PSLS+ ++ V ++DV D + P+F Y L + EN N+P + E
Sbjct: 424 AMDTGPPSLSAETMIEVLISDVND-----NPPIFREDSYILTVREN-NSPAVFIGKVHAE 477
Query: 1284 HY---ENFKMRYYIL--NENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
EN ++ Y +L D + I+ NG LY +R+ D E ++ +V+A
Sbjct: 478 DLDLGENAQITYSLLPPKNGDLSVFAYISINSGNGKLYALRTMDYEAIQDFQFVVKATDG 537
Query: 1339 KYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTNGNRPLVTAIPTT 1394
+ L ++ V+VVV D NDN P NG P +P +
Sbjct: 538 GF---------------LSLSSQVTVRVVV--LDDNDNRPMILYPLQNGTLPCNDLVPRS 580
Query: 1395 APFGYQVMQLKGAIG 1409
A GY V ++ G
Sbjct: 581 AEAGYLVTKVVAVDG 595
Score = 96.7 bits (230), Expect = 6e-19
Identities = 119/499 (23%), Positives = 198/499 (39%), Gaps = 34/499 (6%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E L SF EV + D NDN PVF+ + + +G+ A D D+G NG+
Sbjct: 112 EPLQSF-RAEVRVFDINDNAPVFLNKEPL-LKIPESTPLGSRFPLQSAQDLDVGLNGLQN 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHA---LFVEASDQPANPSERRYSLA 553
Y L + + F + V P+ L + A D + P +
Sbjct: 170 YTLSANGYFHLHTRFCSHGPKYAELVLNKPLDREEQPEVNLTITAVDGGSPPKSGTAHIH 229
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND--VSYDLL 611
VV ++V +P F Y V N G+ V + D E + ++Y L
Sbjct: 230 VVVLDVN-------DHVPQFSRLVYRAQVSENSPNGSLVATVTAVDLDEGTNKAITYSLA 282
Query: 612 HGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
E + F ++ ++G + + L YD + A + LS + V VVDVN
Sbjct: 283 QNPEAILKTFQIDPQNGEVRLRGPLDFEAIETYDIDIQAT-DGGGLSAHSKVLVEVVDVN 341
Query: 671 DERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D V++ SP+ E+S + +F I G V +
Sbjct: 342 DNPPEVMVSSVSSPL----PEDSPPQTVVALFTIRDRDIRVGG--KVTCFLREDLPFVIK 395
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
++ T + LDRE+ Y +T++A + G S + + + I D NDNPP+F
Sbjct: 396 PTFGNSYSLVTDRSLDREEVSGYNITIVA-MDTGPPSLSAETMIEVLISDVNDNPPIFRE 454
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF----GEGKEMFDVDENTGV 845
+Y + EN+ I + A D D G NA Y+L G+ + N+G
Sbjct: 455 DSYILTVRENNSPAVFI---GKVHAEDLDLGENAQITYSLLPPKNGDLSVFAYISINSGN 511
Query: 846 VKFIG-DSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKV 902
K ++D E ++ + A D G LSS+ + +++ D+NDN+P +N +
Sbjct: 512 GKLYALRTMDYEAIQDFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQNGTL 571
Query: 903 RIHRETKLNGTAGFTIIEV 921
+ + AG+ + +V
Sbjct: 572 PCNDLVPRSAEAGYLVTKV 590
Score = 72.9 bits (171), Expect = 8e-12
Identities = 104/458 (22%), Positives = 190/458 (41%), Gaps = 35/458 (7%)
Query: 444 NVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTS 503
++ V +LD ND+ P F +Y + N+ G+++ V AVD D G N + Y L +
Sbjct: 227 HIHVVVLDVNDHVPQF-SRLVYRAQVSENSPNGSLVATVTAVDLDEGTNKAITYSLAQNP 285
Query: 504 NLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPSERRYSLAVVTIEVTR 561
I F+I+P G V + E + + ++A+D + + + VV +
Sbjct: 286 E-AILKTFQIDPQNGEVRLRGPLDFEAIETYDIDIQATDGGGLSAHSKVLVEVVDVN--- 341
Query: 562 GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFA 621
+ P P+ M + + + T V + D V + E +PF
Sbjct: 342 ----DNP--PEVMVSSVSSPLPEDSPPQTVVALFTIRD--RDIRVGGKVTCFLREDLPFV 393
Query: 622 VEERSG-VITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLL 677
++ G ++V D L R Y+ VA+ +LS T V + DVND +
Sbjct: 394 IKPTFGNSYSLVTDRSLDREEVSGYNITIVAMDTGPPSLSAETMIEVLISDVNDNPPIFR 453
Query: 678 KGAHSPIIFHVKENSAGAA-IGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIA--- 733
+ ++ I V+EN++ A IG++ H + N L D++ I+
Sbjct: 454 EDSY---ILTVRENNSPAVFIGKV-HAEDLDLGENAQITYSLLPPKNGDLSVFAYISINS 509
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
+G ++ + +D E ++ V A + G +S + V + + D+NDN P+ +
Sbjct: 510 GNGKLYALRTMDYEAIQDFQFVVKAT-DGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQN 568
Query: 794 GFIMENSKIGTEIKMDNIIK---ATDADEGTNALFMYTLF-GEGKEMFDVDENTGVVKFI 849
G + N + + ++ A D D G N+ Y L +F V G + +
Sbjct: 569 GTLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLLKATDLGLFSVQRQNGEIHTL 628
Query: 850 GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
+R+ +M KL ++ +D G LS+ L I++ D
Sbjct: 629 RQISERD-PMMQKLIILVQDHGQPALSTTVSLNILLVD 665
Score = 71.7 bits (168), Expect = 2e-11
Identities = 54/172 (31%), Positives = 83/172 (48%), Gaps = 11/172 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELD--LDAEHNLQANTFVLQVQ 277
A D D+G+ Y L + L + +G + E L+ LD E + N L +
Sbjct: 157 AQDLDVGLNGLQNYTLSANGYFHLHTRFCSHGPKYAELVLNKPLDREEQPEVN---LTIT 213
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A +P K+ A + + +LD+ND++P+F Y + EN PNG V V A D D+G
Sbjct: 214 AVDGGSPPKSGTAHIHVVVLDVNDHVPQFSRLVYRAQVSENSPNGSLVATVTAVDLDEGT 273
Query: 338 NGEFTYQL-DDPKG---AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
N TY L +P+ F IDP++G VR + LD EA + + + A +
Sbjct: 274 NKAITYSLAQNPEAILKTFQIDPQNG--EVRLRGPLDFEAIETYDIDIQATD 323
Score = 60.5 bits (140), Expect = 5e-08
Identities = 90/354 (25%), Positives = 154/354 (43%), Gaps = 33/354 (9%)
Query: 32 VSVILAQSIDSLVDSDS--PQN-VVKFRLGCDFD--EGDDLVRIGAGLNQISAYLSVTVY 86
++ LAQ+ ++++ + PQN V+ R DF+ E D+ +SA+ V V
Sbjct: 277 ITYSLAQNPEAILKTFQIDPQNGEVRLRGPLDFEAIETYDIDIQATDGGGLSAHSKVLVE 336
Query: 87 IEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP----IGPSLTIPLTVPRGLTI-- 140
+ DVNDN P + + + E +P +F I +G +T L I
Sbjct: 337 VVDVNDNPPEVMVSSVSSPLPEDSPPQTVVALFTIRDRDIRVGGKVTCFLREDLPFVIKP 396
Query: 141 -FKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQ 198
F + + D+ Y+I + D G +L + +L+ V D +E
Sbjct: 397 TFGNSYSLVTDRSLDREEVSGYNITIVAMDTGPPSLSAETMIEVLISDVNDNPPIFREDS 456
Query: 199 LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELI--SGNDRKLF---SLDSVNGSL 253
++ + + +F +HA D DLG A + Y L+ D +F S++S NG L
Sbjct: 457 YILTV--RENNSPAVFIGKVHAEDLDLGENAQITYSLLPPKNGDLSVFAYISINSGNGKL 514
Query: 254 FLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNI 313
+ + +D +A + Q FV V+A+ ++Q V + +LD NDN P N
Sbjct: 515 YALRTMDYEAIQDFQ---FV--VKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQNG 569
Query: 314 SIVEN--LPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSG 359
++ N +P G+ V +V+A D D G+N +Y L G FS+ ++G
Sbjct: 570 TLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLLKATDLGLFSVQRQNG 623
Score = 59.7 bits (138), Expect = 8e-08
Identities = 58/201 (28%), Positives = 93/201 (46%), Gaps = 20/201 (9%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
+ + EN I K++A DLD G N QI Y +PP + D L V Y IN
Sbjct: 458 ILTVRENNSPAVFIGKVHAEDLDLGENAQITYSL-----LPPK--NGD-LSVFAYISINS 509
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+G + R++ E+ +F+ + A DGG +L+ ++VRV V D ND+ P+ N
Sbjct: 510 GNGKLYALRTMDYEAIQDFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQNG 569
Query: 1053 N------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP-FEISPLTGVLSVN 1105
V + ++ KV A D D GQN+ L+Y + + TDL F + G +
Sbjct: 570 TLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLLKA-TDLGLFSVQRQNGEIHTL 628
Query: 1106 GELDRETEDKYILTVVARDNG 1126
++ L ++ +D+G
Sbjct: 629 RQISERDPMMQKLIILVQDHG 649
Score = 55.2 bits (127), Expect = 2e-06
Identities = 48/174 (27%), Positives = 77/174 (44%), Gaps = 11/174 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR--KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A+D D G + Y L + K F +D NG + L LD +A T+ +
Sbjct: 264 VTAVDLDEGTNKAITYSLAQNPEAILKTFQIDPQNGEVRLRGPLDFEA-----IETYDID 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
+QA+ +A ++V +E++D+NDN PE V + + E+ P V D+D
Sbjct: 319 IQATDGGG--LSAHSKVLVEVVDVNDNPPEVMVSSVSSPLPEDSPPQTVVALFTIRDRDI 376
Query: 336 GENGEFTYQLDDPKGAFSIDPRSG-WLTVRNQTVLDREAHSSLRMKVYAKETNP 388
G+ T L + F I P G ++ LDRE S + + A +T P
Sbjct: 377 RVGGKVTCFLREDL-PFVIKPTFGNSYSLVTDRSLDREEVSGYNITIVAMDTGP 429
Score = 44.0 bits (99), Expect = 0.004
Identities = 40/134 (29%), Positives = 63/134 (47%), Gaps = 5/134 (3%)
Query: 224 DLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNN 283
++G A L+S ++ F L G LF++++LD ++ +A+ VL + L
Sbjct: 55 EVGKLAARGARLVSEGNKMHFRLHRKTGDLFVKEKLDRESLCG-KADPCVLHFEVV-LVE 112
Query: 284 PLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTY 343
PL++ +A E+ + D+NDN P F + I E+ P G A D D G NG Y
Sbjct: 113 PLQSFRA--EVRVFDINDNAPVFLNKEPLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNY 170
Query: 344 QLDDPKGAFSIDPR 357
L G F + R
Sbjct: 171 TL-SANGYFHLHTR 183
>BC098346-1|AAH98346.1| 795|Homo sapiens protocadherin beta 4
protein.
Length = 795
Score = 107 bits (256), Expect = 4e-22
Identities = 118/475 (24%), Positives = 197/475 (41%), Gaps = 34/475 (7%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
+ + + E + F E+ + D ND++P+F P + N++ GT+ + A D D+G
Sbjct: 104 HFQVFLEMPVQFFQGELLIQDINDHSPIF-PEREVLLKILENSQPGTLFPLLIAEDLDVG 162
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSE 547
NG+ Y + S+ I + V + P+ + +L + A D + P
Sbjct: 163 SNGLQKYTISPNSHFHILTRNHSEGKKYPDLVQDKPLDREEQPEFSLTLVALDGGSPPRS 222
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQN--D 605
+ ++ +++ + P+F+ PY V N + + + ++ D N
Sbjct: 223 GTVMVRILIMDIN-------DNAPEFVHTPYGVQVLENSPLDSPIVRVLARDIDAGNFGS 275
Query: 606 VSYDLLHGYEE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
VSY L +E F++ E +G I + L Y E A + LS +
Sbjct: 276 VSYGLFQASDEIKQTFSINEVTGEILLKKKLDFEKIKSYHVEIEAT-DGGGLSGKGTVVI 334
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
VVDVND L+ S + + EN+ + IF NG + I +
Sbjct: 335 EVVDVNDNPPELII---SSLTSSIPENAPETVVS-IFRIRDRDSGENG--KMICSIPDNL 388
Query: 725 DVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
+ T+ T++PLDRE Y +T IA + G +T+ + D NDN
Sbjct: 389 PFILKPTLKNFYTLVTERPLDRETSAEYNIT-IAVTDLGTPRLKTQQNITVQVSDVNDNA 447
Query: 785 PVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFD 838
P F +Y F+ EN+ I + ATD D GTNA Y+L +
Sbjct: 448 PAFTQTSYTLFVRENNSPALHI---GSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVS 504
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
++ + G + F SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 505 INADNGHL-FALRSLDYEALQAFEFRVGASDRGSPALSSEALVRVLVLDTNDNSP 558
Score = 86.2 bits (204), Expect = 8e-16
Identities = 132/500 (26%), Positives = 203/500 (40%), Gaps = 71/500 (14%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEF--NSEVYIPPSKLSADALEVKRY-FV 993
L I EN GT L A DLD G NG +Y NS +I L+ + E K+Y +
Sbjct: 138 LLKILENSQPGTLFPLLIAEDLDVGSNGLQKYTISPNSHFHI----LTRNHSEGKKYPDL 193
Query: 994 INERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYN 1051
+ ++ + R PE F L + ALDGG+ + + VR+ + D+ND+ P F T Y
Sbjct: 194 VQDKP----LDREEQPE--FSLTLVALDGGSPPRSGTVMVRILIMDINDNAPEFVHTPYG 247
Query: 1052 FNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSD-TDLPFEISPLTGVLSVNGELD 1109
V E + +V A D D G +++Y Q SD F I+ +TG + + +LD
Sbjct: 248 VQVLENSPLDSPIVRVLARDIDAGNFGSVSYGLFQASDEIKQTFSINEVTGEILLKKKLD 307
Query: 1110 RETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY--AFDELLEWKHPEA-- 1165
E Y + + A D G DVNDN P+ + + PE
Sbjct: 308 FEKIKSYHVEIEATDGG---GLSGKGTVVIEVVDVNDNPPELIISSLTSSIPENAPETVV 364
Query: 1166 ------DELSNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYS 1217
D S N + + IP +N P + T+ + T+ + Y+
Sbjct: 365 SIFRIRDRDSGENGKMICSIP-------DNLPFILKPTLKNFYTLVTERPLDRETSAEYN 417
Query: 1218 LPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELV 1277
+ +LG P L + + V V+DV D + P F Y L + EN + + +
Sbjct: 418 ITIAVT--DLGTPRLKTQQNITVQVSDVND-----NAPAFTQTSYTLFVRENNSPALHIG 470
Query: 1278 SLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREVKDTYEVIV 1333
S++ T+ N ++ Y +L D + + I+ NG L+ +RS D E +E V
Sbjct: 471 SVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEALQAFEFRV 530
Query: 1334 RAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTNGNRPLVT 1389
A R P + + V V + D NDNSP NG+ P
Sbjct: 531 GAS----DRGSPAL-------------SSEALVRVLVLDTNDNSPFVLYPLQNGSAPCTE 573
Query: 1390 AIPTTAPFGYQVMQLKGAIG 1409
+P A GY V ++ G
Sbjct: 574 LVPRAAEPGYLVTKVVAVDG 593
Score = 85.4 bits (202), Expect = 1e-15
Identities = 56/154 (36%), Positives = 80/154 (51%), Gaps = 8/154 (5%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
KPLDRE++ + +T++A + G +G V I I D NDN P F H Y ++ENS
Sbjct: 197 KPLDREEQPEFSLTLVA-LDGGSPPRSGTVMVRILIMDINDNAPEFVHTPYGVQVLENSP 255
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLF---GEGKEMFDVDENTGVVKFIGDSLDREKK 858
+ + I + A D D G Y LF E K+ F ++E TG + + LD EK
Sbjct: 256 LDSPIVR---VLARDIDAGNFGSVSYGLFQASDEIKQTFSINEVTGEI-LLKKKLDFEKI 311
Query: 859 IMYKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
Y + + A D GGLS + ++I + D NDN PE
Sbjct: 312 KSYHVEIEATDGGGLSGKGTVVIEVVDVNDNPPE 345
Score = 66.1 bits (154), Expect = 9e-10
Identities = 81/324 (25%), Positives = 135/324 (41%), Gaps = 29/324 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTP-TGEKAFIFLIAPIGPSLTIPLTVPRGLTI 140
+V + + DVNDN P + + ++ E P T F G + + ++P L
Sbjct: 331 TVVIEVVDVNDNPPELIISSLTSSIPENAPETVVSIFRIRDRDSGENGKMICSIPDNLPF 390
Query: 141 F-----KDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
K+ ++P + Y+I ++ D G L++ + + V D
Sbjct: 391 ILKPTLKNFYTLVTERPLDRETSAEYNITIAVTDLGTPRLKTQQNITVQVSDVNDNAPAF 450
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLFSLDSV 249
+ + + + L + A D+D G A + Y L+ D L S+++
Sbjct: 451 TQTSYTLFV--RENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINAD 508
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
NG LF + LD +A LQA F +V AS +P +++A V + +LD NDN P
Sbjct: 509 NGHLFALRSLDYEA---LQA--FEFRVGASDRGSPALSSEALVRVLVLDTNDNSPFVLYP 563
Query: 310 FYNIS--IVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWL 361
N S E +P G+ V +V+A D D G+N +YQL G F + +G
Sbjct: 564 LQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG-- 621
Query: 362 TVRNQTVLDREAHSSLRMKVYAKE 385
VR +L + R+ V K+
Sbjct: 622 EVRTARLLSERDAAKHRLVVLVKD 645
Score = 62.5 bits (145), Expect = 1e-08
Identities = 48/177 (27%), Positives = 84/177 (47%), Gaps = 8/177 (4%)
Query: 213 LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
LFP I A D D+G +Y + + + + + G + + D + Q F
Sbjct: 150 LFPLLI-AEDLDVGSNGLQKYTISPNSHFHILTRNHSEGKKYPDLVQDKPLDREEQPE-F 207
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
L + A +P ++ V I ++D+NDN PEF Y + ++EN P +++V+A D
Sbjct: 208 SLTLVALDGGSPPRSGTVMVRILIMDINDNAPEFVHTPYGVQVLENSPLDSPIVRVLARD 267
Query: 333 KDQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D G G +Y L D+ K FSI+ +G + ++ + LD E S +++ A +
Sbjct: 268 IDAGNFGSVSYGLFQASDEIKQTFSINEVTGEILLKKK--LDFEKIKSYHVEIEATD 322
Score = 61.7 bits (143), Expect = 2e-08
Identities = 71/282 (25%), Positives = 111/282 (39%), Gaps = 17/282 (6%)
Query: 635 LSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSA 693
L R +P + VAL + S + ++D+ND + H+P V ENS
Sbjct: 199 LDREEQPEFSLTLVALDGGSPPRSGTVMVRILIMDINDNAPEFV---HTPYGVQVLENSP 255
Query: 694 GAAIGQIFHTNMSSIYGNGTGNVRF-LIANQQDVTDDIAIAE-DGTIFTQKPLDREKRDV 751
I I G+V + L ++ +I E G I +K LD EK
Sbjct: 256 --LDSPIVRVLARDIDAGNFGSVSYGLFQASDEIKQTFSINEVTGEILLKKKLDFEKIKS 313
Query: 752 YRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNI 811
Y + + A + G +SG G V I + D NDNPP ++ I EN+ T + +I
Sbjct: 314 YHVEIEAT-DGGGLSGKGT--VVIEVVDVNDNPPELIISSLTSSIPENAP-ETVV---SI 366
Query: 812 IKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG 871
+ D D G N + ++ + LDRE Y +++ D G
Sbjct: 367 FRIRDRDSGENGKMICSIPDNLPFILKPTLKNFYTLVTERPLDRETSAEYNITIAVTDLG 426
Query: 872 G--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
L ++ + + + D NDN P F Q VR + L+
Sbjct: 427 TPRLKTQQNITVQVSDVNDNAPAFTQTSYTLFVRENNSPALH 468
Score = 61.3 bits (142), Expect = 3e-08
Identities = 51/203 (25%), Positives = 96/203 (47%), Gaps = 17/203 (8%)
Query: 186 KVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI---DQDLGVGATLRYELISGND-- 240
++L D D + V G ++ + PI + D D G ++ Y L +D
Sbjct: 228 RILIMDINDNAPEFVHTPYGVQVLENSPLDSPIVRVLARDIDAGNFGSVSYGLFQASDEI 287
Query: 241 RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLN 300
++ FS++ V G + L+K+LD + + ++ ++++A+ + + V IE++D+N
Sbjct: 288 KQTFSINEVTGEILLKKKLDFE-----KIKSYHVEIEATDGGG--LSGKGTVVIEVVDVN 340
Query: 301 DNLPEFEVDFYNISIVENLPNGFSVLQVM-ATDKDQGENGEFTYQLDDPKGAFSIDPR-S 358
DN PE + SI EN P +V+ + D+D GENG+ + D F + P
Sbjct: 341 DNPPELIISSLTSSIPENAPE--TVVSIFRIRDRDSGENGKMICSIPD-NLPFILKPTLK 397
Query: 359 GWLTVRNQTVLDREAHSSLRMKV 381
+ T+ + LDRE + + +
Sbjct: 398 NFYTLVTERPLDRETSAEYNITI 420
Score = 59.7 bits (138), Expect = 8e-08
Identities = 62/218 (28%), Positives = 88/218 (40%), Gaps = 18/218 (8%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
++V N A Q + EN I ++A D DSG N Q+ Y +PP
Sbjct: 438 VQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSL-----LPP 492
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVF 1034
L + IN +GH+ RSL E+ F + A D G+ L+ VRV
Sbjct: 493 QD---PHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGASDRGSPALSSEALVRVL 549
Query: 1035 VKDVNDHFPVFKKTWYNFN------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
V D ND+ P N + V A ++ KV A D D GQNA L+Y + +
Sbjct: 550 VLDTNDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKAT 609
Query: 1089 TDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
F + G + L K+ L V+ +DNG
Sbjct: 610 EPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNG 647
Score = 46.8 bits (106), Expect = 6e-04
Identities = 75/365 (20%), Positives = 141/365 (38%), Gaps = 49/365 (13%)
Query: 1033 VFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP 1092
+ ++D+NDH P+F + + E + + A D D G N Y I P+
Sbjct: 120 LLIQDINDHSPIFPEREVLLKILENSQPGTLFPLLIAEDLDVGSNGLQKYTISPNSHFHI 179
Query: 1093 FEISPLTGV----LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
+ G L + LDRE + ++ LT+VA D G D+NDN+
Sbjct: 180 LTRNHSEGKKYPDLVQDKPLDREEQPEFSLTLVALDGG-SPPRSGTVMVRILIMDINDNA 238
Query: 1149 PKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIG 1208
P+F H V ++ EN+P+ + + +V A D D G
Sbjct: 239 PEFV------------------HTPYGVQVL--------ENSPLDSPIVRVLARDID-AG 271
Query: 1209 NGNGLILYSLPQRKNQ--QNLGLPSLSSTAIL-----MVTVADVPDEVEMSDKPVFISR- 1260
N G + Y L Q ++ Q + ++ +L + E+E +D +
Sbjct: 272 N-FGSVSYGLFQASDEIKQTFSINEVTGEILLKKKLDFEKIKSYHVEIEATDGGGLSGKG 330
Query: 1261 YYELEIEENVNAPVELVSLNLT----EHYENFKMRYYILNENDTDIRRTFVIDPRNGTLY 1316
+E+ + + P EL+ +LT E+ + + + + D+ + + +
Sbjct: 331 TVVIEVVDVNDNPPELIISSLTSSIPENAPETVVSIFRIRDRDSGENGKMICSIPDNLPF 390
Query: 1317 LVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDN 1376
+++ +K+ Y ++ + + I D+ K + V++ DVNDN
Sbjct: 391 ILKP---TLKNFYTLVTERPLDR-ETSAEYNITIAVTDLGTPRLKTQQNITVQVSDVNDN 446
Query: 1377 SPKFT 1381
+P FT
Sbjct: 447 APAFT 451
Score = 44.4 bits (100), Expect = 0.003
Identities = 43/141 (30%), Positives = 65/141 (46%), Gaps = 7/141 (4%)
Query: 220 AIDQDLGVG--ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
A D LG+G A+ ++S +D++ LD G L L ++LD + E VL Q
Sbjct: 48 AKDLGLGIGELASRSARVLSDDDKQRLQLDRQTGDLLLREKLDRE-ELCGPIEPCVLHFQ 106
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
L P++ Q + I+ D+ND+ P F + I+EN G ++A D D G
Sbjct: 107 VF-LEMPVQFFQGELLIQ--DINDHSPIFPEREVLLKILENSQPGTLFPLLIAEDLDVGS 163
Query: 338 NGEFTYQLDDPKGAFSIDPRS 358
NG Y + P F I R+
Sbjct: 164 NGLQKYTI-SPNSHFHILTRN 183
Score = 37.9 bits (84), Expect = 0.28
Identities = 37/126 (29%), Positives = 53/126 (42%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LD NDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 540 LSSEALVRVLVLDTNDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 598
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + + + N T + S +H L V D P +L
Sbjct: 599 AWLSYQLLKATEPGLFGVWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 657
Query: 553 AVVTIE 558
V+ ++
Sbjct: 658 HVLLVD 663
Score = 37.1 bits (82), Expect = 0.48
Identities = 19/45 (42%), Positives = 25/45 (55%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTP 111
LV + G S + V + I D+NDN P F+ TPY V V E +P
Sbjct: 211 LVALDGGSPPRSGTVMVRILIMDINDNAPEFVHTPYGVQVLENSP 255
Score = 33.1 bits (72), Expect = 7.9
Identities = 14/36 (38%), Positives = 20/36 (55%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE 108
G ++ ++TV + DVNDN P F T Y + V E
Sbjct: 426 GTPRLKTQQNITVQVSDVNDNAPAFTQTSYTLFVRE 461
>BC098139-1|AAH98139.1| 795|Homo sapiens protocadherin beta 4
protein.
Length = 795
Score = 107 bits (256), Expect = 4e-22
Identities = 118/475 (24%), Positives = 197/475 (41%), Gaps = 34/475 (7%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
+ + + E + F E+ + D ND++P+F P + N++ GT+ + A D D+G
Sbjct: 104 HFQVFLEMPVQFFQGELLIQDINDHSPIF-PEREVLLKILENSQPGTLFPLLIAEDLDVG 162
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSE 547
NG+ Y + S+ I + V + P+ + +L + A D + P
Sbjct: 163 SNGLQKYTISPNSHFHILTRNHSEGKKYPDLVQDKPLDREEQPEFSLTLVALDGGSPPRS 222
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQN--D 605
+ ++ +++ + P+F+ PY V N + + + ++ D N
Sbjct: 223 GTVMVRILIMDIN-------DNAPEFVHTPYGVQVLENSPLDSPIVRVLARDIDAGNFGS 275
Query: 606 VSYDLLHGYEE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
VSY L +E F++ E +G I + L Y E A + LS +
Sbjct: 276 VSYGLFQASDEIKQTFSINEVTGEILLKKKLDFEKIKSYHVEIEAT-DGGGLSGKGTVVI 334
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
VVDVND L+ S + + EN+ + IF NG + I +
Sbjct: 335 EVVDVNDNPPELII---SSLTSSIPENAPETVVS-IFRIRDRDSGENG--KMICSIPDNL 388
Query: 725 DVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
+ T+ T++PLDRE Y +T IA + G +T+ + D NDN
Sbjct: 389 PFILKPTLKNFYTLVTERPLDRETSAEYNIT-IAVTDLGTPRLKTQQNITVQVSDVNDNA 447
Query: 785 PVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFD 838
P F +Y F+ EN+ I + ATD D GTNA Y+L +
Sbjct: 448 PAFTQTSYTLFVRENNSPALHI---GSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVS 504
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
++ + G + F SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 505 INADNGHL-FALRSLDYEALQAFEFRVGASDRGSPALSSEALVRVLVLDTNDNSP 558
Score = 86.2 bits (204), Expect = 8e-16
Identities = 132/500 (26%), Positives = 203/500 (40%), Gaps = 71/500 (14%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEF--NSEVYIPPSKLSADALEVKRY-FV 993
L I EN GT L A DLD G NG +Y NS +I L+ + E K+Y +
Sbjct: 138 LLKILENSQPGTLFPLLIAEDLDVGSNGLQKYTISPNSHFHI----LTRNHSEGKKYPDL 193
Query: 994 INERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYN 1051
+ ++ + R PE F L + ALDGG+ + + VR+ + D+ND+ P F T Y
Sbjct: 194 VQDKP----LDREEQPE--FSLTLVALDGGSPPRSGTVMVRILIMDINDNAPEFVHTPYG 247
Query: 1052 FNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSD-TDLPFEISPLTGVLSVNGELD 1109
V E + +V A D D G +++Y Q SD F I+ +TG + + +LD
Sbjct: 248 VQVLENSPLDSPIVRVLARDIDAGNFGSVSYGLFQASDEIKQTFSINEVTGEILLKKKLD 307
Query: 1110 RETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY--AFDELLEWKHPEA-- 1165
E Y + + A D G DVNDN P+ + + PE
Sbjct: 308 FEKIKSYHVEIEATDGG---GLSGKGTVVIEVVDVNDNPPELIISSLTSSIPENAPETVV 364
Query: 1166 ------DELSNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYS 1217
D S N + + IP +N P + T+ + T+ + Y+
Sbjct: 365 SIFRIRDRDSGENGKMICSIP-------DNLPFILKPTLKNFYTLVTERPLDRETSAEYN 417
Query: 1218 LPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELV 1277
+ +LG P L + + V V+DV D + P F Y L + EN + + +
Sbjct: 418 ITIAVT--DLGTPRLKTQQNITVQVSDVND-----NAPAFTQTSYTLFVRENNSPALHIG 470
Query: 1278 SLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREVKDTYEVIV 1333
S++ T+ N ++ Y +L D + + I+ NG L+ +RS D E +E V
Sbjct: 471 SVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEALQAFEFRV 530
Query: 1334 RAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTNGNRPLVT 1389
A R P + + V V + D NDNSP NG+ P
Sbjct: 531 GAS----DRGSPAL-------------SSEALVRVLVLDTNDNSPFVLYPLQNGSAPCTE 573
Query: 1390 AIPTTAPFGYQVMQLKGAIG 1409
+P A GY V ++ G
Sbjct: 574 LVPRAAEPGYLVTKVVAVDG 593
Score = 85.4 bits (202), Expect = 1e-15
Identities = 56/154 (36%), Positives = 80/154 (51%), Gaps = 8/154 (5%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
KPLDRE++ + +T++A + G +G V I I D NDN P F H Y ++ENS
Sbjct: 197 KPLDREEQPEFSLTLVA-LDGGSPPRSGTVMVRILIMDINDNAPEFVHTPYGVQVLENSP 255
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLF---GEGKEMFDVDENTGVVKFIGDSLDREKK 858
+ + I + A D D G Y LF E K+ F ++E TG + + LD EK
Sbjct: 256 LDSPIVR---VLARDIDAGNFGSVSYGLFQASDEIKQTFSINEVTGEI-LLKKKLDFEKI 311
Query: 859 IMYKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
Y + + A D GGLS + ++I + D NDN PE
Sbjct: 312 KSYHVEIEATDGGGLSGKGTVVIEVVDVNDNPPE 345
Score = 66.1 bits (154), Expect = 9e-10
Identities = 81/324 (25%), Positives = 135/324 (41%), Gaps = 29/324 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTP-TGEKAFIFLIAPIGPSLTIPLTVPRGLTI 140
+V + + DVNDN P + + ++ E P T F G + + ++P L
Sbjct: 331 TVVIEVVDVNDNPPELIISSLTSSIPENAPETVVSIFRIRDRDSGENGKMICSIPDNLPF 390
Query: 141 F-----KDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
K+ ++P + Y+I ++ D G L++ + + V D
Sbjct: 391 ILKPTLKNFYTLVTERPLDRETSAEYNITIAVTDLGTPRLKTQQNITVQVSDVNDNAPAF 450
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLFSLDSV 249
+ + + + L + A D+D G A + Y L+ D L S+++
Sbjct: 451 TQTSYTLFV--RENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINAD 508
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
NG LF + LD +A LQA F +V AS +P +++A V + +LD NDN P
Sbjct: 509 NGHLFALRSLDYEA---LQA--FEFRVGASDRGSPALSSEALVRVLVLDTNDNSPFVLYP 563
Query: 310 FYNIS--IVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWL 361
N S E +P G+ V +V+A D D G+N +YQL G F + +G
Sbjct: 564 LQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG-- 621
Query: 362 TVRNQTVLDREAHSSLRMKVYAKE 385
VR +L + R+ V K+
Sbjct: 622 EVRTARLLSERDAAKHRLVVLVKD 645
Score = 62.5 bits (145), Expect = 1e-08
Identities = 48/177 (27%), Positives = 84/177 (47%), Gaps = 8/177 (4%)
Query: 213 LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
LFP I A D D+G +Y + + + + + G + + D + Q F
Sbjct: 150 LFPLLI-AEDLDVGSNGLQKYTISPNSHFHILTRNHSEGKKYPDLVQDKPLDREEQPE-F 207
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
L + A +P ++ V I ++D+NDN PEF Y + ++EN P +++V+A D
Sbjct: 208 SLTLVALDGGSPPRSGTVMVRILIMDINDNAPEFVHTPYGVQVLENSPLDSPIVRVLARD 267
Query: 333 KDQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D G G +Y L D+ K FSI+ +G + ++ + LD E S +++ A +
Sbjct: 268 IDAGNFGSVSYGLFQASDEIKQTFSINEVTGEILLKKK--LDFEKIKSYHVEIEATD 322
Score = 61.7 bits (143), Expect = 2e-08
Identities = 71/282 (25%), Positives = 111/282 (39%), Gaps = 17/282 (6%)
Query: 635 LSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSA 693
L R +P + VAL + S + ++D+ND + H+P V ENS
Sbjct: 199 LDREEQPEFSLTLVALDGGSPPRSGTVMVRILIMDINDNAPEFV---HTPYGVQVLENSP 255
Query: 694 GAAIGQIFHTNMSSIYGNGTGNVRF-LIANQQDVTDDIAIAE-DGTIFTQKPLDREKRDV 751
I I G+V + L ++ +I E G I +K LD EK
Sbjct: 256 --LDSPIVRVLARDIDAGNFGSVSYGLFQASDEIKQTFSINEVTGEILLKKKLDFEKIKS 313
Query: 752 YRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNI 811
Y + + A + G +SG G V I + D NDNPP ++ I EN+ T + +I
Sbjct: 314 YHVEIEAT-DGGGLSGKGT--VVIEVVDVNDNPPELIISSLTSSIPENAP-ETVV---SI 366
Query: 812 IKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG 871
+ D D G N + ++ + LDRE Y +++ D G
Sbjct: 367 FRIRDRDSGENGKMICSIPDNLPFILKPTLKNFYTLVTERPLDRETSAEYNITIAVTDLG 426
Query: 872 G--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
L ++ + + + D NDN P F Q VR + L+
Sbjct: 427 TPRLKTQQNITVQVSDVNDNAPAFTQTSYTLFVRENNSPALH 468
Score = 61.3 bits (142), Expect = 3e-08
Identities = 51/203 (25%), Positives = 96/203 (47%), Gaps = 17/203 (8%)
Query: 186 KVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI---DQDLGVGATLRYELISGND-- 240
++L D D + V G ++ + PI + D D G ++ Y L +D
Sbjct: 228 RILIMDINDNAPEFVHTPYGVQVLENSPLDSPIVRVLARDIDAGNFGSVSYGLFQASDEI 287
Query: 241 RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLN 300
++ FS++ V G + L+K+LD + + ++ ++++A+ + + V IE++D+N
Sbjct: 288 KQTFSINEVTGEILLKKKLDFE-----KIKSYHVEIEATDGGG--LSGKGTVVIEVVDVN 340
Query: 301 DNLPEFEVDFYNISIVENLPNGFSVLQVM-ATDKDQGENGEFTYQLDDPKGAFSIDPR-S 358
DN PE + SI EN P +V+ + D+D GENG+ + D F + P
Sbjct: 341 DNPPELIISSLTSSIPENAPE--TVVSIFRIRDRDSGENGKMICSIPD-NLPFILKPTLK 397
Query: 359 GWLTVRNQTVLDREAHSSLRMKV 381
+ T+ + LDRE + + +
Sbjct: 398 NFYTLVTERPLDRETSAEYNITI 420
Score = 59.7 bits (138), Expect = 8e-08
Identities = 62/218 (28%), Positives = 88/218 (40%), Gaps = 18/218 (8%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
++V N A Q + EN I ++A D DSG N Q+ Y +PP
Sbjct: 438 VQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSL-----LPP 492
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVF 1034
L + IN +GH+ RSL E+ F + A D G+ L+ VRV
Sbjct: 493 QD---PHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGASDRGSPALSSEALVRVL 549
Query: 1035 VKDVNDHFPVFKKTWYNFN------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
V D ND+ P N + V A ++ KV A D D GQNA L+Y + +
Sbjct: 550 VLDTNDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKAT 609
Query: 1089 TDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
F + G + L K+ L V+ +DNG
Sbjct: 610 EPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNG 647
Score = 46.8 bits (106), Expect = 6e-04
Identities = 75/365 (20%), Positives = 141/365 (38%), Gaps = 49/365 (13%)
Query: 1033 VFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP 1092
+ ++D+NDH P+F + + E + + A D D G N Y I P+
Sbjct: 120 LLIQDINDHSPIFPEREVLLKILENSQPGTLFPLLIAEDLDVGSNGLQKYTISPNSHFHI 179
Query: 1093 FEISPLTGV----LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
+ G L + LDRE + ++ LT+VA D G D+NDN+
Sbjct: 180 LTRNHSEGKKYPDLVQDKPLDREEQPEFSLTLVALDGG-SPPRSGTVMVRILIMDINDNA 238
Query: 1149 PKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIG 1208
P+F H V ++ EN+P+ + + +V A D D G
Sbjct: 239 PEFV------------------HTPYGVQVL--------ENSPLDSPIVRVLARDID-AG 271
Query: 1209 NGNGLILYSLPQRKNQ--QNLGLPSLSSTAIL-----MVTVADVPDEVEMSDKPVFISR- 1260
N G + Y L Q ++ Q + ++ +L + E+E +D +
Sbjct: 272 N-FGSVSYGLFQASDEIKQTFSINEVTGEILLKKKLDFEKIKSYHVEIEATDGGGLSGKG 330
Query: 1261 YYELEIEENVNAPVELVSLNLT----EHYENFKMRYYILNENDTDIRRTFVIDPRNGTLY 1316
+E+ + + P EL+ +LT E+ + + + + D+ + + +
Sbjct: 331 TVVIEVVDVNDNPPELIISSLTSSIPENAPETVVSIFRIRDRDSGENGKMICSIPDNLPF 390
Query: 1317 LVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDN 1376
+++ +K+ Y ++ + + I D+ K + V++ DVNDN
Sbjct: 391 ILKP---TLKNFYTLVTERPLDR-ETSAEYNITIAVTDLGTPRLKTQQNITVQVSDVNDN 446
Query: 1377 SPKFT 1381
+P FT
Sbjct: 447 APAFT 451
Score = 44.4 bits (100), Expect = 0.003
Identities = 43/141 (30%), Positives = 65/141 (46%), Gaps = 7/141 (4%)
Query: 220 AIDQDLGVG--ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
A D LG+G A+ ++S +D++ LD G L L ++LD + E VL Q
Sbjct: 48 AKDLGLGIGELASRSARVLSDDDKQRLQLDRQTGDLLLREKLDRE-ELCGPIEPCVLHFQ 106
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
L P++ Q + I+ D+ND+ P F + I+EN G ++A D D G
Sbjct: 107 VF-LEMPVQFFQGELLIQ--DINDHSPIFPEREVLLKILENSQPGTLFPLLIAEDLDVGS 163
Query: 338 NGEFTYQLDDPKGAFSIDPRS 358
NG Y + P F I R+
Sbjct: 164 NGLQKYTI-SPNSHFHILTRN 183
Score = 37.9 bits (84), Expect = 0.28
Identities = 37/126 (29%), Positives = 53/126 (42%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LD NDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 540 LSSEALVRVLVLDTNDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 598
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + + + N T + S +H L V D P +L
Sbjct: 599 AWLSYQLLKATEPGLFGVWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 657
Query: 553 AVVTIE 558
V+ ++
Sbjct: 658 HVLLVD 663
Score = 37.1 bits (82), Expect = 0.48
Identities = 19/45 (42%), Positives = 25/45 (55%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTP 111
LV + G S + V + I D+NDN P F+ TPY V V E +P
Sbjct: 211 LVALDGGSPPRSGTVMVRILIMDINDNAPEFVHTPYGVQVLENSP 255
Score = 33.1 bits (72), Expect = 7.9
Identities = 14/36 (38%), Positives = 20/36 (55%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE 108
G ++ ++TV + DVNDN P F T Y + V E
Sbjct: 426 GTPRLKTQQNITVQVSDVNDNAPAFTQTSYTLFVRE 461
>AF217754-1|AAK51621.1| 795|Homo sapiens protocadherin-beta4
protein.
Length = 795
Score = 107 bits (256), Expect = 4e-22
Identities = 118/475 (24%), Positives = 197/475 (41%), Gaps = 34/475 (7%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
+ + + E + F E+ + D ND++P+F P + N++ GT+ + A D D+G
Sbjct: 104 HFQVFLEMPVQFFQGELLIQDINDHSPIF-PEREVLLKILENSQPGTLFPLLIAEDLDVG 162
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSE 547
NG+ Y + S+ I + V + P+ + +L + A D + P
Sbjct: 163 SNGLQKYTISPNSHFHILTRNHSEGKKYPDLVQDKPLDREEQPEFSLTLVALDGGSPPRS 222
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQN--D 605
+ ++ +++ + P+F+ PY V N + + + ++ D N
Sbjct: 223 GTVMVRILIMDIN-------DNAPEFVHTPYGVQVLENSPLDSPIVRVLARDIDAGNFGS 275
Query: 606 VSYDLLHGYEE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
VSY L +E F++ E +G I + L Y E A + LS +
Sbjct: 276 VSYGLFQASDEIKQTFSINEVTGEILLKKKLDFEKIKSYHVEIEAT-DGGGLSGKGTVVI 334
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
VVDVND L+ S + + EN+ + IF NG + I +
Sbjct: 335 EVVDVNDNPPELII---SSLTSSIPENAPETVVS-IFRIRDRDSGENG--KMICSIPDNL 388
Query: 725 DVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
+ T+ T++PLDRE Y +T IA + G +T+ + D NDN
Sbjct: 389 PFILKPTLKNFYTLVTERPLDRETSAEYNIT-IAVTDLGTPRLKTQQNITVQVSDVNDNA 447
Query: 785 PVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFD 838
P F +Y F+ EN+ I + ATD D GTNA Y+L +
Sbjct: 448 PAFTQTSYTLFVRENNSPALHI---GSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVS 504
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
++ + G + F SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 505 INADNGHL-FALRSLDYEALQAFEFRVGASDRGSPALSSEALVRVLVLDTNDNSP 558
Score = 86.2 bits (204), Expect = 8e-16
Identities = 132/500 (26%), Positives = 203/500 (40%), Gaps = 71/500 (14%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEF--NSEVYIPPSKLSADALEVKRY-FV 993
L I EN GT L A DLD G NG +Y NS +I L+ + E K+Y +
Sbjct: 138 LLKILENSQPGTLFPLLIAEDLDVGSNGLQKYTISPNSHFHI----LTRNHSEGKKYPDL 193
Query: 994 INERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYN 1051
+ ++ + R PE F L + ALDGG+ + + VR+ + D+ND+ P F T Y
Sbjct: 194 VQDKP----LDREEQPE--FSLTLVALDGGSPPRSGTVMVRILIMDINDNAPEFVHTPYG 247
Query: 1052 FNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSD-TDLPFEISPLTGVLSVNGELD 1109
V E + +V A D D G +++Y Q SD F I+ +TG + + +LD
Sbjct: 248 VQVLENSPLDSPIVRVLARDIDAGNFGSVSYGLFQASDEIKQTFSINEVTGEILLKKKLD 307
Query: 1110 RETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY--AFDELLEWKHPEA-- 1165
E Y + + A D G DVNDN P+ + + PE
Sbjct: 308 FEKIKSYHVEIEATDGG---GLSGKGTVVIEVVDVNDNPPELIISSLTSSIPENAPETVV 364
Query: 1166 ------DELSNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYS 1217
D S N + + IP +N P + T+ + T+ + Y+
Sbjct: 365 SIFRIRDRDSGENGKMICSIP-------DNLPFILKPTLKNFYTLVTERPLDRETSAEYN 417
Query: 1218 LPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELV 1277
+ +LG P L + + V V+DV D + P F Y L + EN + + +
Sbjct: 418 ITIAVT--DLGTPRLKTQQNITVQVSDVND-----NAPAFTQTSYTLFVRENNSPALHIG 470
Query: 1278 SLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREVKDTYEVIV 1333
S++ T+ N ++ Y +L D + + I+ NG L+ +RS D E +E V
Sbjct: 471 SVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEALQAFEFRV 530
Query: 1334 RAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTNGNRPLVT 1389
A R P + + V V + D NDNSP NG+ P
Sbjct: 531 GAS----DRGSPAL-------------SSEALVRVLVLDTNDNSPFVLYPLQNGSAPCTE 573
Query: 1390 AIPTTAPFGYQVMQLKGAIG 1409
+P A GY V ++ G
Sbjct: 574 LVPRAAEPGYLVTKVVAVDG 593
Score = 85.4 bits (202), Expect = 1e-15
Identities = 56/154 (36%), Positives = 80/154 (51%), Gaps = 8/154 (5%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
KPLDRE++ + +T++A + G +G V I I D NDN P F H Y ++ENS
Sbjct: 197 KPLDREEQPEFSLTLVA-LDGGSPPRSGTVMVRILIMDINDNAPEFVHTPYGVQVLENSP 255
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLF---GEGKEMFDVDENTGVVKFIGDSLDREKK 858
+ + I + A D D G Y LF E K+ F ++E TG + + LD EK
Sbjct: 256 LDSPIVR---VLARDIDAGNFGSVSYGLFQASDEIKQTFSINEVTGEI-LLKKKLDFEKI 311
Query: 859 IMYKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
Y + + A D GGLS + ++I + D NDN PE
Sbjct: 312 KSYHVEIEATDGGGLSGKGTVVIEVVDVNDNPPE 345
Score = 66.1 bits (154), Expect = 9e-10
Identities = 81/324 (25%), Positives = 135/324 (41%), Gaps = 29/324 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTP-TGEKAFIFLIAPIGPSLTIPLTVPRGLTI 140
+V + + DVNDN P + + ++ E P T F G + + ++P L
Sbjct: 331 TVVIEVVDVNDNPPELIISSLTSSIPENAPETVVSIFRIRDRDSGENGKMICSIPDNLPF 390
Query: 141 F-----KDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
K+ ++P + Y+I ++ D G L++ + + V D
Sbjct: 391 ILKPTLKNFYTLVTERPLDRETSAEYNITIAVTDLGTPRLKTQQNITVQVSDVNDNAPAF 450
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLFSLDSV 249
+ + + + L + A D+D G A + Y L+ D L S+++
Sbjct: 451 TQTSYTLFV--RENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINAD 508
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
NG LF + LD +A LQA F +V AS +P +++A V + +LD NDN P
Sbjct: 509 NGHLFALRSLDYEA---LQA--FEFRVGASDRGSPALSSEALVRVLVLDTNDNSPFVLYP 563
Query: 310 FYNIS--IVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWL 361
N S E +P G+ V +V+A D D G+N +YQL G F + +G
Sbjct: 564 LQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG-- 621
Query: 362 TVRNQTVLDREAHSSLRMKVYAKE 385
VR +L + R+ V K+
Sbjct: 622 EVRTARLLSERDAAKHRLVVLVKD 645
Score = 62.5 bits (145), Expect = 1e-08
Identities = 48/177 (27%), Positives = 84/177 (47%), Gaps = 8/177 (4%)
Query: 213 LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
LFP I A D D+G +Y + + + + + G + + D + Q F
Sbjct: 150 LFPLLI-AEDLDVGSNGLQKYTISPNSHFHILTRNHSEGKKYPDLVQDKPLDREEQPE-F 207
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
L + A +P ++ V I ++D+NDN PEF Y + ++EN P +++V+A D
Sbjct: 208 SLTLVALDGGSPPRSGTVMVRILIMDINDNAPEFVHTPYGVQVLENSPLDSPIVRVLARD 267
Query: 333 KDQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D G G +Y L D+ K FSI+ +G + ++ + LD E S +++ A +
Sbjct: 268 IDAGNFGSVSYGLFQASDEIKQTFSINEVTGEILLKKK--LDFEKIKSYHVEIEATD 322
Score = 61.7 bits (143), Expect = 2e-08
Identities = 71/282 (25%), Positives = 111/282 (39%), Gaps = 17/282 (6%)
Query: 635 LSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSA 693
L R +P + VAL + S + ++D+ND + H+P V ENS
Sbjct: 199 LDREEQPEFSLTLVALDGGSPPRSGTVMVRILIMDINDNAPEFV---HTPYGVQVLENSP 255
Query: 694 GAAIGQIFHTNMSSIYGNGTGNVRF-LIANQQDVTDDIAIAE-DGTIFTQKPLDREKRDV 751
I I G+V + L ++ +I E G I +K LD EK
Sbjct: 256 --LDSPIVRVLARDIDAGNFGSVSYGLFQASDEIKQTFSINEVTGEILLKKKLDFEKIKS 313
Query: 752 YRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNI 811
Y + + A + G +SG G V I + D NDNPP ++ I EN+ T + +I
Sbjct: 314 YHVEIEAT-DGGGLSGKGT--VVIEVVDVNDNPPELIISSLTSSIPENAP-ETVV---SI 366
Query: 812 IKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG 871
+ D D G N + ++ + LDRE Y +++ D G
Sbjct: 367 FRIRDRDSGENGKMICSIPDNLPFILKPTLKNFYTLVTERPLDRETSAEYNITIAVTDLG 426
Query: 872 G--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
L ++ + + + D NDN P F Q VR + L+
Sbjct: 427 TPRLKTQQNITVQVSDVNDNAPAFTQTSYTLFVRENNSPALH 468
Score = 61.3 bits (142), Expect = 3e-08
Identities = 51/203 (25%), Positives = 96/203 (47%), Gaps = 17/203 (8%)
Query: 186 KVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI---DQDLGVGATLRYELISGND-- 240
++L D D + V G ++ + PI + D D G ++ Y L +D
Sbjct: 228 RILIMDINDNAPEFVHTPYGVQVLENSPLDSPIVRVLARDIDAGNFGSVSYGLFQASDEI 287
Query: 241 RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLN 300
++ FS++ V G + L+K+LD + + ++ ++++A+ + + V IE++D+N
Sbjct: 288 KQTFSINEVTGEILLKKKLDFE-----KIKSYHVEIEATDGGG--LSGKGTVVIEVVDVN 340
Query: 301 DNLPEFEVDFYNISIVENLPNGFSVLQVM-ATDKDQGENGEFTYQLDDPKGAFSIDPR-S 358
DN PE + SI EN P +V+ + D+D GENG+ + D F + P
Sbjct: 341 DNPPELIISSLTSSIPENAPE--TVVSIFRIRDRDSGENGKMICSIPD-NLPFILKPTLK 397
Query: 359 GWLTVRNQTVLDREAHSSLRMKV 381
+ T+ + LDRE + + +
Sbjct: 398 NFYTLVTERPLDRETSAEYNITI 420
Score = 59.7 bits (138), Expect = 8e-08
Identities = 62/218 (28%), Positives = 88/218 (40%), Gaps = 18/218 (8%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
++V N A Q + EN I ++A D DSG N Q+ Y +PP
Sbjct: 438 VQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSL-----LPP 492
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVF 1034
L + IN +GH+ RSL E+ F + A D G+ L+ VRV
Sbjct: 493 QD---PHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGASDRGSPALSSEALVRVL 549
Query: 1035 VKDVNDHFPVFKKTWYNFN------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
V D ND+ P N + V A ++ KV A D D GQNA L+Y + +
Sbjct: 550 VLDTNDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKAT 609
Query: 1089 TDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
F + G + L K+ L V+ +DNG
Sbjct: 610 EPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNG 647
Score = 46.8 bits (106), Expect = 6e-04
Identities = 75/365 (20%), Positives = 141/365 (38%), Gaps = 49/365 (13%)
Query: 1033 VFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP 1092
+ ++D+NDH P+F + + E + + A D D G N Y I P+
Sbjct: 120 LLIQDINDHSPIFPEREVLLKILENSQPGTLFPLLIAEDLDVGSNGLQKYTISPNSHFHI 179
Query: 1093 FEISPLTGV----LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
+ G L + LDRE + ++ LT+VA D G D+NDN+
Sbjct: 180 LTRNHSEGKKYPDLVQDKPLDREEQPEFSLTLVALDGG-SPPRSGTVMVRILIMDINDNA 238
Query: 1149 PKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIG 1208
P+F H V ++ EN+P+ + + +V A D D G
Sbjct: 239 PEFV------------------HTPYGVQVL--------ENSPLDSPIVRVLARDID-AG 271
Query: 1209 NGNGLILYSLPQRKNQ--QNLGLPSLSSTAIL-----MVTVADVPDEVEMSDKPVFISR- 1260
N G + Y L Q ++ Q + ++ +L + E+E +D +
Sbjct: 272 N-FGSVSYGLFQASDEIKQTFSINEVTGEILLKKKLDFEKIKSYHVEIEATDGGGLSGKG 330
Query: 1261 YYELEIEENVNAPVELVSLNLT----EHYENFKMRYYILNENDTDIRRTFVIDPRNGTLY 1316
+E+ + + P EL+ +LT E+ + + + + D+ + + +
Sbjct: 331 TVVIEVVDVNDNPPELIISSLTSSIPENAPETVVSIFRIRDRDSGENGKMICSIPDNLPF 390
Query: 1317 LVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDN 1376
+++ +K+ Y ++ + + I D+ K + V++ DVNDN
Sbjct: 391 ILKP---TLKNFYTLVTERPLDR-ETSAEYNITIAVTDLGTPRLKTQQNITVQVSDVNDN 446
Query: 1377 SPKFT 1381
+P FT
Sbjct: 447 APAFT 451
Score = 44.4 bits (100), Expect = 0.003
Identities = 43/141 (30%), Positives = 65/141 (46%), Gaps = 7/141 (4%)
Query: 220 AIDQDLGVG--ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
A D LG+G A+ ++S +D++ LD G L L ++LD + E VL Q
Sbjct: 48 AKDLGLGIGELASRSARVLSDDDKQRLQLDRQTGDLLLREKLDRE-ELCGPIEPCVLHFQ 106
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
L P++ Q + I+ D+ND+ P F + I+EN G ++A D D G
Sbjct: 107 VF-LEMPVQFFQGELLIQ--DINDHSPIFPEREVLLKILENSQPGTLFPLLIAEDLDVGS 163
Query: 338 NGEFTYQLDDPKGAFSIDPRS 358
NG Y + P F I R+
Sbjct: 164 NGLQKYTI-SPNSHFHILTRN 183
Score = 37.9 bits (84), Expect = 0.28
Identities = 37/126 (29%), Positives = 53/126 (42%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LD NDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 540 LSSEALVRVLVLDTNDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 598
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + + + N T + S +H L V D P +L
Sbjct: 599 AWLSYQLLKATEPGLFGVWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 657
Query: 553 AVVTIE 558
V+ ++
Sbjct: 658 HVLLVD 663
Score = 37.1 bits (82), Expect = 0.48
Identities = 19/45 (42%), Positives = 25/45 (55%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTP 111
LV + G S + V + I D+NDN P F+ TPY V V E +P
Sbjct: 211 LVALDGGSPPRSGTVMVRILIMDINDNAPEFVHTPYGVQVLENSP 255
Score = 33.1 bits (72), Expect = 7.9
Identities = 14/36 (38%), Positives = 20/36 (55%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE 108
G ++ ++TV + DVNDN P F T Y + V E
Sbjct: 426 GTPRLKTQQNITVQVSDVNDNAPAFTQTSYTLFVRE 461
>AF152497-1|AAD43758.1| 795|Homo sapiens protocadherin beta 4
protein.
Length = 795
Score = 107 bits (256), Expect = 4e-22
Identities = 118/475 (24%), Positives = 197/475 (41%), Gaps = 34/475 (7%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
+ + + E + F E+ + D ND++P+F P + N++ GT+ + A D D+G
Sbjct: 104 HFQVFLEMPVQFFQGELLIQDINDHSPIF-PEREVLLKILENSQPGTLFPLLIAEDLDVG 162
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSE 547
NG+ Y + S+ I + V + P+ + +L + A D + P
Sbjct: 163 SNGLQKYTISPNSHFHILTRNHSEGKKYPDLVQDKPLDREEQPEFSLTLVALDGGSPPRS 222
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQN--D 605
+ ++ +++ + P+F+ PY V N + + + ++ D N
Sbjct: 223 GTVMVRILIMDIN-------DNAPEFVHTPYGVQVLENSPLDSPIVRVLARDIDAGNFGS 275
Query: 606 VSYDLLHGYEE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
VSY L +E F++ E +G I + L Y E A + LS +
Sbjct: 276 VSYGLFQASDEIKQTFSINEVTGEILLKKKLDFEKIKSYHVEIEAT-DGGGLSGKGTVVI 334
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
VVDVND L+ S + + EN+ + IF NG + I +
Sbjct: 335 EVVDVNDNPPELII---SSLTSSIPENAPETVVS-IFRIRDRDSGENG--KMICSIPDNL 388
Query: 725 DVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
+ T+ T++PLDRE Y +T IA + G +T+ + D NDN
Sbjct: 389 PFILKPTLKNFYTLVTERPLDRETSAEYNIT-IAVTDLGTPRLKTQQNITVQVSDVNDNA 447
Query: 785 PVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFD 838
P F +Y F+ EN+ I + ATD D GTNA Y+L +
Sbjct: 448 PAFTQTSYTLFVRENNSPALHI---GSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVS 504
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
++ + G + F SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 505 INADNGHL-FALRSLDYEALQAFEFRVGASDRGSPALSSEALVRVLVLDTNDNSP 558
Score = 86.2 bits (204), Expect = 8e-16
Identities = 132/500 (26%), Positives = 203/500 (40%), Gaps = 71/500 (14%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEF--NSEVYIPPSKLSADALEVKRY-FV 993
L I EN GT L A DLD G NG +Y NS +I L+ + E K+Y +
Sbjct: 138 LLKILENSQPGTLFPLLIAEDLDVGSNGLQKYTISPNSHFHI----LTRNHSEGKKYPDL 193
Query: 994 INERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYN 1051
+ ++ + R PE F L + ALDGG+ + + VR+ + D+ND+ P F T Y
Sbjct: 194 VQDKP----LDREEQPE--FSLTLVALDGGSPPRSGTVMVRILIMDINDNAPEFVHTPYG 247
Query: 1052 FNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSD-TDLPFEISPLTGVLSVNGELD 1109
V E + +V A D D G +++Y Q SD F I+ +TG + + +LD
Sbjct: 248 VQVLENSPLDSPIVRVLARDIDAGNFGSVSYGLFQASDEIKQTFSINEVTGEILLKKKLD 307
Query: 1110 RETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY--AFDELLEWKHPEA-- 1165
E Y + + A D G DVNDN P+ + + PE
Sbjct: 308 FEKIKSYHVEIEATDGG---GLSGKGTVVIEVVDVNDNPPELIISSLTSSIPENAPETVV 364
Query: 1166 ------DELSNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYS 1217
D S N + + IP +N P + T+ + T+ + Y+
Sbjct: 365 SIFRIRDRDSGENGKMICSIP-------DNLPFILKPTLKNFYTLVTERPLDRETSAEYN 417
Query: 1218 LPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELV 1277
+ +LG P L + + V V+DV D + P F Y L + EN + + +
Sbjct: 418 ITIAVT--DLGTPRLKTQQNITVQVSDVND-----NAPAFTQTSYTLFVRENNSPALHIG 470
Query: 1278 SLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREVKDTYEVIV 1333
S++ T+ N ++ Y +L D + + I+ NG L+ +RS D E +E V
Sbjct: 471 SVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEALQAFEFRV 530
Query: 1334 RAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTNGNRPLVT 1389
A R P + + V V + D NDNSP NG+ P
Sbjct: 531 GAS----DRGSPAL-------------SSEALVRVLVLDTNDNSPFVLYPLQNGSAPCTE 573
Query: 1390 AIPTTAPFGYQVMQLKGAIG 1409
+P A GY V ++ G
Sbjct: 574 LVPRAAEPGYLVTKVVAVDG 593
Score = 85.4 bits (202), Expect = 1e-15
Identities = 56/154 (36%), Positives = 80/154 (51%), Gaps = 8/154 (5%)
Query: 742 KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSK 801
KPLDRE++ + +T++A + G +G V I I D NDN P F H Y ++ENS
Sbjct: 197 KPLDREEQPEFSLTLVA-LDGGSPPRSGTVMVRILIMDINDNAPEFVHTPYGVQVLENSP 255
Query: 802 IGTEIKMDNIIKATDADEGTNALFMYTLF---GEGKEMFDVDENTGVVKFIGDSLDREKK 858
+ + I + A D D G Y LF E K+ F ++E TG + + LD EK
Sbjct: 256 LDSPIVR---VLARDIDAGNFGSVSYGLFQASDEIKQTFSINEVTGEI-LLKKKLDFEKI 311
Query: 859 IMYKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
Y + + A D GGLS + ++I + D NDN PE
Sbjct: 312 KSYHVEIEATDGGGLSGKGTVVIEVVDVNDNPPE 345
Score = 66.1 bits (154), Expect = 9e-10
Identities = 81/324 (25%), Positives = 135/324 (41%), Gaps = 29/324 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTP-TGEKAFIFLIAPIGPSLTIPLTVPRGLTI 140
+V + + DVNDN P + + ++ E P T F G + + ++P L
Sbjct: 331 TVVIEVVDVNDNPPELIISSLTSSIPENAPETVVSIFRIRDRDSGENGKMICSIPDNLPF 390
Query: 141 F-----KDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
K+ ++P + Y+I ++ D G L++ + + V D
Sbjct: 391 ILKPTLKNFYTLVTERPLDRETSAEYNITIAVTDLGTPRLKTQQNITVQVSDVNDNAPAF 450
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLFSLDSV 249
+ + + + L + A D+D G A + Y L+ D L S+++
Sbjct: 451 TQTSYTLFV--RENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINAD 508
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
NG LF + LD +A LQA F +V AS +P +++A V + +LD NDN P
Sbjct: 509 NGHLFALRSLDYEA---LQA--FEFRVGASDRGSPALSSEALVRVLVLDTNDNSPFVLYP 563
Query: 310 FYNIS--IVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWL 361
N S E +P G+ V +V+A D D G+N +YQL G F + +G
Sbjct: 564 LQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG-- 621
Query: 362 TVRNQTVLDREAHSSLRMKVYAKE 385
VR +L + R+ V K+
Sbjct: 622 EVRTARLLSERDAAKHRLVVLVKD 645
Score = 62.5 bits (145), Expect = 1e-08
Identities = 48/177 (27%), Positives = 84/177 (47%), Gaps = 8/177 (4%)
Query: 213 LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
LFP I A D D+G +Y + + + + + G + + D + Q F
Sbjct: 150 LFPLLI-AEDLDVGSNGLQKYTISPNSHFHILTRNHSEGKKYPDLVQDKPLDREEQPE-F 207
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
L + A +P ++ V I ++D+NDN PEF Y + ++EN P +++V+A D
Sbjct: 208 SLTLVALDGGSPPRSGTVMVRILIMDINDNAPEFVHTPYGVQVLENSPLDSPIVRVLARD 267
Query: 333 KDQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D G G +Y L D+ K FSI+ +G + ++ + LD E S +++ A +
Sbjct: 268 IDAGNFGSVSYGLFQASDEIKQTFSINEVTGEILLKKK--LDFEKIKSYHVEIEATD 322
Score = 61.7 bits (143), Expect = 2e-08
Identities = 71/282 (25%), Positives = 111/282 (39%), Gaps = 17/282 (6%)
Query: 635 LSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSA 693
L R +P + VAL + S + ++D+ND + H+P V ENS
Sbjct: 199 LDREEQPEFSLTLVALDGGSPPRSGTVMVRILIMDINDNAPEFV---HTPYGVQVLENSP 255
Query: 694 GAAIGQIFHTNMSSIYGNGTGNVRF-LIANQQDVTDDIAIAE-DGTIFTQKPLDREKRDV 751
I I G+V + L ++ +I E G I +K LD EK
Sbjct: 256 --LDSPIVRVLARDIDAGNFGSVSYGLFQASDEIKQTFSINEVTGEILLKKKLDFEKIKS 313
Query: 752 YRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNI 811
Y + + A + G +SG G V I + D NDNPP ++ I EN+ T + +I
Sbjct: 314 YHVEIEAT-DGGGLSGKGT--VVIEVVDVNDNPPELIISSLTSSIPENAP-ETVV---SI 366
Query: 812 IKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG 871
+ D D G N + ++ + LDRE Y +++ D G
Sbjct: 367 FRIRDRDSGENGKMICSIPDNLPFILKPTLKNFYTLVTERPLDRETSAEYNITIAVTDLG 426
Query: 872 G--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
L ++ + + + D NDN P F Q VR + L+
Sbjct: 427 TPRLKTQQNITVQVSDVNDNAPAFTQTSYTLFVRENNSPALH 468
Score = 61.3 bits (142), Expect = 3e-08
Identities = 51/203 (25%), Positives = 96/203 (47%), Gaps = 17/203 (8%)
Query: 186 KVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI---DQDLGVGATLRYELISGND-- 240
++L D D + V G ++ + PI + D D G ++ Y L +D
Sbjct: 228 RILIMDINDNAPEFVHTPYGVQVLENSPLDSPIVRVLARDIDAGNFGSVSYGLFQASDEI 287
Query: 241 RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLN 300
++ FS++ V G + L+K+LD + + ++ ++++A+ + + V IE++D+N
Sbjct: 288 KQTFSINEVTGEILLKKKLDFE-----KIKSYHVEIEATDGGG--LSGKGTVVIEVVDVN 340
Query: 301 DNLPEFEVDFYNISIVENLPNGFSVLQVM-ATDKDQGENGEFTYQLDDPKGAFSIDPR-S 358
DN PE + SI EN P +V+ + D+D GENG+ + D F + P
Sbjct: 341 DNPPELIISSLTSSIPENAPE--TVVSIFRIRDRDSGENGKMICSIPD-NLPFILKPTLK 397
Query: 359 GWLTVRNQTVLDREAHSSLRMKV 381
+ T+ + LDRE + + +
Sbjct: 398 NFYTLVTERPLDRETSAEYNITI 420
Score = 59.7 bits (138), Expect = 8e-08
Identities = 62/218 (28%), Positives = 88/218 (40%), Gaps = 18/218 (8%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
++V N A Q + EN I ++A D DSG N Q+ Y +PP
Sbjct: 438 VQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSL-----LPP 492
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVF 1034
L + IN +GH+ RSL E+ F + A D G+ L+ VRV
Sbjct: 493 QD---PHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGASDRGSPALSSEALVRVL 549
Query: 1035 VKDVNDHFPVFKKTWYNFN------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
V D ND+ P N + V A ++ KV A D D GQNA L+Y + +
Sbjct: 550 VLDTNDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKAT 609
Query: 1089 TDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
F + G + L K+ L V+ +DNG
Sbjct: 610 EPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNG 647
Score = 46.8 bits (106), Expect = 6e-04
Identities = 75/365 (20%), Positives = 141/365 (38%), Gaps = 49/365 (13%)
Query: 1033 VFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP 1092
+ ++D+NDH P+F + + E + + A D D G N Y I P+
Sbjct: 120 LLIQDINDHSPIFPEREVLLKILENSQPGTLFPLLIAEDLDVGSNGLQKYTISPNSHFHI 179
Query: 1093 FEISPLTGV----LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
+ G L + LDRE + ++ LT+VA D G D+NDN+
Sbjct: 180 LTRNHSEGKKYPDLVQDKPLDREEQPEFSLTLVALDGG-SPPRSGTVMVRILIMDINDNA 238
Query: 1149 PKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIG 1208
P+F H V ++ EN+P+ + + +V A D D G
Sbjct: 239 PEFV------------------HTPYGVQVL--------ENSPLDSPIVRVLARDID-AG 271
Query: 1209 NGNGLILYSLPQRKNQ--QNLGLPSLSSTAIL-----MVTVADVPDEVEMSDKPVFISR- 1260
N G + Y L Q ++ Q + ++ +L + E+E +D +
Sbjct: 272 N-FGSVSYGLFQASDEIKQTFSINEVTGEILLKKKLDFEKIKSYHVEIEATDGGGLSGKG 330
Query: 1261 YYELEIEENVNAPVELVSLNLT----EHYENFKMRYYILNENDTDIRRTFVIDPRNGTLY 1316
+E+ + + P EL+ +LT E+ + + + + D+ + + +
Sbjct: 331 TVVIEVVDVNDNPPELIISSLTSSIPENAPETVVSIFRIRDRDSGENGKMICSIPDNLPF 390
Query: 1317 LVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDN 1376
+++ +K+ Y ++ + + I D+ K + V++ DVNDN
Sbjct: 391 ILKP---TLKNFYTLVTERPLDR-ETSAEYNITIAVTDLGTPRLKTQQNITVQVSDVNDN 446
Query: 1377 SPKFT 1381
+P FT
Sbjct: 447 APAFT 451
Score = 44.4 bits (100), Expect = 0.003
Identities = 43/141 (30%), Positives = 65/141 (46%), Gaps = 7/141 (4%)
Query: 220 AIDQDLGVG--ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
A D LG+G A+ ++S +D++ LD G L L ++LD + E VL Q
Sbjct: 48 AKDLGLGIGELASRSARVLSDDDKQRLQLDRQTGDLLLREKLDRE-ELCGPIEPCVLHFQ 106
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
L P++ Q + I+ D+ND+ P F + I+EN G ++A D D G
Sbjct: 107 VF-LEMPVQFFQGELLIQ--DINDHSPIFPEREVLLKILENSQPGTLFPLLIAEDLDVGS 163
Query: 338 NGEFTYQLDDPKGAFSIDPRS 358
NG Y + P F I R+
Sbjct: 164 NGLQKYTI-SPNSHFHILTRN 183
Score = 37.9 bits (84), Expect = 0.28
Identities = 37/126 (29%), Positives = 53/126 (42%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LD NDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 540 LSSEALVRVLVLDTNDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 598
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + + + N T + S +H L V D P +L
Sbjct: 599 AWLSYQLLKATEPGLFGVWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 657
Query: 553 AVVTIE 558
V+ ++
Sbjct: 658 HVLLVD 663
Score = 37.1 bits (82), Expect = 0.48
Identities = 19/45 (42%), Positives = 25/45 (55%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTP 111
LV + G S + V + I D+NDN P F+ TPY V V E +P
Sbjct: 211 LVALDGGSPPRSGTVMVRILIMDINDNAPEFVHTPYGVQVLENSP 255
Score = 33.1 bits (72), Expect = 7.9
Identities = 14/36 (38%), Positives = 20/36 (55%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE 108
G ++ ++TV + DVNDN P F T Y + V E
Sbjct: 426 GTPRLKTQQNITVQVSDVNDNAPAFTQTSYTLFVRE 461
>BC038799-1|AAH38799.1| 745|Homo sapiens PCDH21 protein protein.
Length = 745
Score = 106 bits (255), Expect = 5e-22
Identities = 117/469 (24%), Positives = 194/469 (41%), Gaps = 29/469 (6%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V + + DAND P F+ Y + + G++I KV AVD D G G V Y LQ
Sbjct: 121 VVILVTDANDEAPRFIQEP-YVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQ---- 175
Query: 505 LTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVV---TIEVTR 561
+ SPF ++ ++G + + L+ + + + R + VV T VT
Sbjct: 176 -NLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTV 234
Query: 562 GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVP 619
+ + P F+G PY +V + G+ V ++ D + N + Y L++G +G
Sbjct: 235 NVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNG-NDGA- 292
Query: 620 FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV----HVVDVNDERGV 675
F + E SG I++ ++ R +Y+ + + S ATV +VD+N+
Sbjct: 293 FEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPT 352
Query: 676 LL--KGAHSPIIFHVKENSAGAAI--GQIFHTNMSSIYGNGTGNVRFLIANQ--QDVTDD 729
G + + E+ I G N S N N++ + + V
Sbjct: 353 FYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQT 412
Query: 730 IAIAEDGTIFTQK--PLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVF 787
+ TI + +D EK V ++A + V I + D NDN P F
Sbjct: 413 VLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKF 472
Query: 788 EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVV- 846
+ Y I EN+ G+ + + A D D G Y+ +G G ++F + +TG++
Sbjct: 473 DSLYYVARIPENAPGGSSVV---AVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIY 529
Query: 847 KFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQ 895
SLD E Y + A D G S AE+ I + D ND+ P+F +
Sbjct: 530 TQPWASLDAEATARYNFYVKAEDMEGKYSVAEVFITLLDVNDHPPQFGK 578
Score = 85.8 bits (203), Expect = 1e-15
Identities = 139/596 (23%), Positives = 239/596 (40%), Gaps = 85/596 (14%)
Query: 580 FWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN 639
F + + +G+ V + D E + +SY + F+V+ G IT+V++L R
Sbjct: 42 FSLPEDTPVGSHVYTLNGTDP-EGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDRER 100
Query: 640 RPMYDFEAV-ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKEN-SAGAAI 697
+ EA+ ++ + NL + + V D NDE ++ P + V E+ AG+ I
Sbjct: 101 ED--EIEAIISISDGLNL-VAEKVVILVTDANDEAPRFIQ---EPYVALVPEDIPAGSII 154
Query: 698 GQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQK--PLDREKRDVYRM 754
++ + + G+G G+V + + Q++ A+ G + Q LD E+ + +
Sbjct: 155 FKVHAVDRDT--GSG-GSVTYFL---QNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYI 208
Query: 755 TVIAEFNKGVISGAGIY-----QVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMD 809
TV+A+ G + GA + VT+ +ED D PVF Y G++ E++ G+E+
Sbjct: 209 TVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLK- 267
Query: 810 NIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARD 869
+ A D D G +Y+L F+++E +G + ++++ Y+L + +
Sbjct: 268 --VVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREV-YELHVQVTE 324
Query: 870 TGGLSSEA-----ELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPK 924
S A + I I D N++ P F G +G P+
Sbjct: 325 MSPAGSPAAQATVPVTIRIVDLNNHPPTF-----------------YGESG-------PQ 360
Query: 925 NKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSAD 984
N+F L +++ P I +K+ D D G N +FN ++ P
Sbjct: 361 NRFELSMNEHPPQGEILRG-------LKITVNDSDQGANA----KFNLQLVGP-----RG 404
Query: 985 ALEVKRYFVINERHGHVIVARSLPPESE------FR-LNISALDGGNLNDNISVRVFVKD 1037
V V+NE +IV S + E F+ L + + V + + D
Sbjct: 405 IFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLD 464
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISP 1097
ND+ P F +Y + E + V A D D G + Y + DL F I P
Sbjct: 465 TNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADL-FLIHP 523
Query: 1098 LTGVLSVN--GELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
TG++ LD E +Y V A D DVND+ P+F
Sbjct: 524 STGLIYTQPWASLDAEATARYNFYVKAED---MEGKYSVAEVFITLLDVNDHPPQF 576
Score = 68.5 bits (160), Expect = 2e-10
Identities = 76/274 (27%), Positives = 118/274 (43%), Gaps = 22/274 (8%)
Query: 211 EILFPEPIHAIDQDLGVGATLRYELISGNDRKLFS------LDSVNGSLFLEKELDLDAE 264
EIL I D D G A +L+ R +F L+ ++ +E +D E
Sbjct: 375 EILRGLKITVNDSDQGANAKFNLQLVG--PRGIFRVVPQTVLNEAQVTIIVENSAAIDFE 432
Query: 265 HNLQANTFVLQVQASQLNNPLK-TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGF 323
++ ++ A ++N P K ++ A V I+LLD NDN+P+F+ +Y I EN P G
Sbjct: 433 ---KSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGS 489
Query: 324 SVLQVMATDKDQGENGEFTYQ-LDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVY 382
SV+ V A D D G GE Y F I P +G + + LD EA + V
Sbjct: 490 SVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVK 549
Query: 383 AK--ETNPSVVGTFADSQRIAKWRRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLM 440
A+ E SV F + P + ++K T V V K E I+ E+
Sbjct: 550 AEDMEGKYSVAEVFI---TLLDVNDHPPQFGKSVQKKTMVLGTPV--KIEAIDEDAEEPN 604
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
+ V+ +T A N + S+ E +K++ +
Sbjct: 605 NLVDYSIT--HAEPANVFDINSHTGEIWLKNSIR 636
Score = 68.1 bits (159), Expect = 2e-10
Identities = 43/145 (29%), Positives = 71/145 (48%), Gaps = 8/145 (5%)
Query: 241 RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLN 300
R +FS+D G++ L +ELD + E ++A +++ L +V I + D N
Sbjct: 78 RSVFSVDPTFGNITLVEELDREREDEIEA--------IISISDGLNLVAEKVVILVTDAN 129
Query: 301 DNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGW 360
D P F + Y + E++P G + +V A D+D G G TY L + F++D SG
Sbjct: 130 DEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGV 189
Query: 361 LTVRNQTVLDREAHSSLRMKVYAKE 385
L ++ LD E + + V AK+
Sbjct: 190 LRLQAGATLDYERSRTHYITVVAKD 214
Score = 67.3 bits (157), Expect = 4e-10
Identities = 110/466 (23%), Positives = 195/466 (41%), Gaps = 50/466 (10%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V + D D PVFV + Y + + G+ + KV A+D D G+ +LY L ++
Sbjct: 232 VTVNVEDVQDMAPVFVGTPYYGYVYEDTLP-GSEVLKVVAMDGDRGKPNRILYSLVNGND 290
Query: 505 LTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRGTK 564
F+IN +G +S+ +SP R + +P+ + A V + +
Sbjct: 291 ----GAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDL 346
Query: 565 GNKPDIPDFMGAP-----YEFWVGSNVGIGTSVG--QIRVNDAFEQNDVSYDLL----HG 613
N P P F G +E + + G + +I VND+ + + ++L G
Sbjct: 347 NNHP--PTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRG 404
Query: 614 YEEGVPFAVEERSGVITVVDDLSRYN---RPMYDFEAVALQENA--NLSIVTNATVHVVD 668
VP V + V +V++ + + + F+ +A++ N S + + ++D
Sbjct: 405 IFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLD 464
Query: 669 VNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTD 728
ND + K + + EN+ G + + T + G G V++ + D
Sbjct: 465 TNDN---VPKFDSLYYVARIPENAPGGS-SVVAVTAVDPDTGPW-GEVKY--STYGTGAD 517
Query: 729 DIAI-AEDGTIFTQK--PLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP 785
I G I+TQ LD E Y V AE +G S A ++ I + D ND+PP
Sbjct: 518 LFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYSVAEVF---ITLLDVNDHPP 574
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGV 845
F + + ++ +GT +K++ I + DA+E N + E +FD++ +TG
Sbjct: 575 QFGKSVQKKTMV----LGTPVKIEAIDE--DAEEPNNLVDYSITHAEPANVFDINSHTGE 628
Query: 846 V--KFIGDSLDREKKI------MYKLSLVARDTGGLSSEAELIIMI 883
+ K SLD I ++ L + A+D G S ++ I
Sbjct: 629 IWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKI 674
Score = 66.5 bits (155), Expect = 7e-10
Identities = 54/194 (27%), Positives = 92/194 (47%), Gaps = 23/194 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + Y L++GND F ++ +G++ + + + LQ + L VQ +
Sbjct: 270 AMDGDRGKPNRILYSLVNGNDGA-FEINETSGAISITQ-----SPAQLQREVYELHVQVT 323
Query: 280 QLN---NPLKTAQARVEIELLDLNDNLPEF-----EVDFYNISIVENLPNG--FSVLQVM 329
+++ +P A V I ++DLN++ P F + + +S+ E+ P G L++
Sbjct: 324 EMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKIT 383
Query: 330 ATDKDQGENGEFTYQLDDPKGAFSIDPRS------GWLTVRNQTVLDREAHSSLRMKVYA 383
D DQG N +F QL P+G F + P++ + V N +D E L K+ A
Sbjct: 384 VNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLA 443
Query: 384 KETN-PSVVGTFAD 396
E N P + AD
Sbjct: 444 VEVNTPEKFSSTAD 457
Score = 64.9 bits (151), Expect = 2e-09
Identities = 107/470 (22%), Positives = 192/470 (40%), Gaps = 50/470 (10%)
Query: 454 DNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKI 513
DN N+ FS+ + VG+ + + DP+ + Y + + + + S F +
Sbjct: 29 DNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPE---GDPISYHI--SFDPSTRSVFSV 83
Query: 514 NPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIPDF 573
+P G +++ E L+ +EA ++ L +V +V + P F
Sbjct: 84 DPTFGNITLVEE--LDREREDEIEAIISISD------GLNLVAEKVVILVTDANDEAPRF 135
Query: 574 MGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITV 631
+ PY V ++ G+ + ++ D V+Y L + + PFAV+ SGV+ +
Sbjct: 136 IQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHS---PFAVDRHSGVLRL 192
Query: 632 VDDLSR-YNRPMYDFEAVALQENAN--------LSIVTNATVHVVDVNDERGVLLKGAHS 682
+ Y R + V ++ S T TV+V DV D V + +
Sbjct: 193 QAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYY 252
Query: 683 PIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQK 742
++ ++ G+ + ++ M G + + + N D +I TQ
Sbjct: 253 GYVY--EDTLPGSEVLKV--VAMDGDRGK-PNRILYSLVNGNDGAFEINETSGAISITQS 307
Query: 743 PLDREKRDVYRMTV-IAEFNK-GVISGAGIYQVTIYIEDENDNPPVFEHAT-----YEGF 795
P + R+VY + V + E + G + VTI I D N++PP F + +E
Sbjct: 308 PAQLQ-REVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELS 366
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDE---NTGVVKFIGDS 852
+ E+ G EI I D+D+G NA F L G V + N V I ++
Sbjct: 367 MNEHPPQG-EILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVEN 425
Query: 853 -----LDREKKIMYKLSLVARDTGG-LSSEAELIIMIGDENDNKPEFNQI 896
++ K + +KL V +T SS A+++I + D NDN P+F+ +
Sbjct: 426 SAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSL 475
Score = 64.5 bits (150), Expect = 3e-09
Identities = 59/194 (30%), Positives = 86/194 (44%), Gaps = 22/194 (11%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
LF +PE+ P+G+ + LN D + I Y + + PS S F ++
Sbjct: 41 LFSLPEDTPVGSHVYTLNGTDPEGD---PISYHISFD----PSTRSV--------FSVDP 85
Query: 997 RHGHVIVARSLPPESEFRLN--ISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNV 1054
G++ + L E E + IS DG NL V + V D ND P F + Y V
Sbjct: 86 TFGNITLVEELDREREDEIEAIISISDGLNLVAE-KVVILVTDANDEAPRFIQEPYVALV 144
Query: 1055 EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGV--LSVNGELDRET 1112
E ++ KV A D D G ++TYF+Q + PF + +GV L LD E
Sbjct: 145 PEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQ--NLHSPFAVDRHSGVLRLQAGATLDYER 202
Query: 1113 EDKYILTVVARDNG 1126
+ +TVVA+D G
Sbjct: 203 SRTHYITVVAKDGG 216
Score = 58.4 bits (135), Expect = 2e-07
Identities = 63/248 (25%), Positives = 107/248 (43%), Gaps = 12/248 (4%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN A +I V N A Q + L+PE+IP G+ I K++A+D D+G G + Y
Sbjct: 114 LNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTY- 172
Query: 970 FNSEVYIPPS-KLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDN 1028
F ++ P + + L ++ ++ + + RL+ + + +
Sbjct: 173 FLQNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVV---FSAT 229
Query: 1029 ISVRVFVKDVNDHFPVFKKT-WYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
+V V V+DV D PVF T +Y + E+ VL KV A D D G+ + Y + +
Sbjct: 230 TTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVL-KVVAMDGDRGKPNRILYSL-VN 287
Query: 1088 DTDLPFEISPLTGVLSVN---GELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDV 1144
D FEI+ +G +S+ +L RE + ++ V D+
Sbjct: 288 GNDGAFEINETSGAISITQSPAQLQREVYELHV-QVTEMSPAGSPAAQATVPVTIRIVDL 346
Query: 1145 NDNSPKFY 1152
N++ P FY
Sbjct: 347 NNHPPTFY 354
Score = 56.8 bits (131), Expect = 6e-07
Identities = 53/197 (26%), Positives = 92/197 (46%), Gaps = 10/197 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN-LQANTFVLQV 276
+HA+D+D G G ++ Y L N F++D +G L L+ LD E + T V +
Sbjct: 157 VHAVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKD 214
Query: 277 QASQLNNP--LKTAQARVEIELLDLNDNLPEFE-VDFYNISIVENLPNGFSVLQVMATDK 333
+L+ + +A V + + D+ D P F +Y + LP G VL+V+A D
Sbjct: 215 GGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLP-GSEVLKVVAMDG 273
Query: 334 DQGENGEFTYQL-DDPKGAFSIDPRSGWLTV-RNQTVLDREAHS-SLRMKVYAKETNPSV 390
D+G+ Y L + GAF I+ SG +++ ++ L RE + +++ + +P+
Sbjct: 274 DRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAA 333
Query: 391 VGTFADSQRIAKWRRQP 407
T + RI P
Sbjct: 334 QATVPVTIRIVDLNNHP 350
Score = 50.4 bits (115), Expect = 5e-05
Identities = 61/199 (30%), Positives = 86/199 (43%), Gaps = 25/199 (12%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S +V + LLD NDN P F S Y + NA G+ + V AVDPD G G V
Sbjct: 450 EKFSSTADVVIQLLDTNDNVPKF-DSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVK 508
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILE----GRHALFVEASDQPANPSERRYSL 552
Y T F I+P+TG + L+ R+ +V+A D E +YS+
Sbjct: 509 YSTYGTG----ADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDM-----EGKYSV 559
Query: 553 AVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN-DAFEQND-VSYDL 610
A V I T + D P G + + +GT V ++ DA E N+ V Y +
Sbjct: 560 AEVFI-----TLLDVNDHPPQFGKSVQ---KKTMVLGTPVKIEAIDEDAEEPNNLVDYSI 611
Query: 611 LHGYEEGVPFAVEERSGVI 629
H V F + +G I
Sbjct: 612 THAEPANV-FDINSHTGEI 629
Score = 37.1 bits (82), Expect = 0.48
Identities = 19/56 (33%), Positives = 27/56 (48%), Gaps = 2/56 (3%)
Query: 62 DEGDDLVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
DE + ++ I GLN ++ V + + D ND P F+ PY V E P G F
Sbjct: 102 DEIEAIISISDGLNLVAE--KVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIF 155
Score = 36.7 bits (81), Expect = 0.64
Identities = 18/38 (47%), Positives = 24/38 (63%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEK 115
SA +VTV +EDV D P+F+ TPY+ V E T G +
Sbjct: 227 SATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSE 264
>AB053448-1|BAB61905.1| 858|Homo sapiens KIAA1775 protein protein.
Length = 858
Score = 106 bits (255), Expect = 5e-22
Identities = 117/469 (24%), Positives = 194/469 (41%), Gaps = 29/469 (6%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V + + DAND P F+ Y + + G++I KV AVD D G G V Y LQ
Sbjct: 120 VVILVTDANDEAPRFIQEP-YVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQ---- 174
Query: 505 LTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVV---TIEVTR 561
+ SPF ++ ++G + + L+ + + + R + VV T VT
Sbjct: 175 -NLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTV 233
Query: 562 GTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVP 619
+ + P F+G PY +V + G+ V ++ D + N + Y L++G +G
Sbjct: 234 NVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNG-NDGA- 291
Query: 620 FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV----HVVDVNDERGV 675
F + E SG I++ ++ R +Y+ + + S ATV +VD+N+
Sbjct: 292 FEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPT 351
Query: 676 LL--KGAHSPIIFHVKENSAGAAI--GQIFHTNMSSIYGNGTGNVRFLIANQ--QDVTDD 729
G + + E+ I G N S N N++ + + V
Sbjct: 352 FYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQT 411
Query: 730 IAIAEDGTIFTQK--PLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVF 787
+ TI + +D EK V ++A + V I + D NDN P F
Sbjct: 412 VLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKF 471
Query: 788 EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVV- 846
+ Y I EN+ G+ + + A D D G Y+ +G G ++F + +TG++
Sbjct: 472 DSLYYVARIPENAPGGSSVV---AVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIY 528
Query: 847 KFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQ 895
SLD E Y + A D G S AE+ I + D ND+ P+F +
Sbjct: 529 TQPWASLDAEATARYNFYVKAEDMEGKYSVAEVFITLLDVNDHPPQFGK 577
Score = 85.8 bits (203), Expect = 1e-15
Identities = 139/596 (23%), Positives = 239/596 (40%), Gaps = 85/596 (14%)
Query: 580 FWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN 639
F + + +G+ V + D E + +SY + F+V+ G IT+V++L R
Sbjct: 41 FSLPEDTPVGSHVYTLNGTDP-EGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDRER 99
Query: 640 RPMYDFEAV-ALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKEN-SAGAAI 697
+ EA+ ++ + NL + + V D NDE ++ P + V E+ AG+ I
Sbjct: 100 ED--EIEAIISISDGLNL-VAEKVVILVTDANDEAPRFIQ---EPYVALVPEDIPAGSII 153
Query: 698 GQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQK--PLDREKRDVYRM 754
++ + + G+G G+V + + Q++ A+ G + Q LD E+ + +
Sbjct: 154 FKVHAVDRDT--GSG-GSVTYFL---QNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYI 207
Query: 755 TVIAEFNKGVISGAGIY-----QVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMD 809
TV+A+ G + GA + VT+ +ED D PVF Y G++ E++ G+E+
Sbjct: 208 TVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLK- 266
Query: 810 NIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARD 869
+ A D D G +Y+L F+++E +G + ++++ Y+L + +
Sbjct: 267 --VVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREV-YELHVQVTE 323
Query: 870 TGGLSSEA-----ELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPK 924
S A + I I D N++ P F G +G P+
Sbjct: 324 MSPAGSPAAQATVPVTIRIVDLNNHPPTF-----------------YGESG-------PQ 359
Query: 925 NKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSAD 984
N+F L +++ P I +K+ D D G N +FN ++ P
Sbjct: 360 NRFELSMNEHPPQGEILRG-------LKITVNDSDQGANA----KFNLQLVGP-----RG 403
Query: 985 ALEVKRYFVINERHGHVIVARSLPPESE------FR-LNISALDGGNLNDNISVRVFVKD 1037
V V+NE +IV S + E F+ L + + V + + D
Sbjct: 404 IFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLD 463
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISP 1097
ND+ P F +Y + E + V A D D G + Y + DL F I P
Sbjct: 464 TNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADL-FLIHP 522
Query: 1098 LTGVLSVN--GELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
TG++ LD E +Y V A D DVND+ P+F
Sbjct: 523 STGLIYTQPWASLDAEATARYNFYVKAED---MEGKYSVAEVFITLLDVNDHPPQF 575
Score = 68.5 bits (160), Expect = 2e-10
Identities = 76/274 (27%), Positives = 118/274 (43%), Gaps = 22/274 (8%)
Query: 211 EILFPEPIHAIDQDLGVGATLRYELISGNDRKLFS------LDSVNGSLFLEKELDLDAE 264
EIL I D D G A +L+ R +F L+ ++ +E +D E
Sbjct: 374 EILRGLKITVNDSDQGANAKFNLQLVG--PRGIFRVVPQTVLNEAQVTIIVENSAAIDFE 431
Query: 265 HNLQANTFVLQVQASQLNNPLK-TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGF 323
++ ++ A ++N P K ++ A V I+LLD NDN+P+F+ +Y I EN P G
Sbjct: 432 ---KSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGS 488
Query: 324 SVLQVMATDKDQGENGEFTYQ-LDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVY 382
SV+ V A D D G GE Y F I P +G + + LD EA + V
Sbjct: 489 SVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVK 548
Query: 383 AK--ETNPSVVGTFADSQRIAKWRRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLM 440
A+ E SV F + P + ++K T V V K E I+ E+
Sbjct: 549 AEDMEGKYSVAEVFI---TLLDVNDHPPQFGKSVQKKTMVLGTPV--KIEAIDEDAEEPN 603
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAK 474
+ V+ +T A N + S+ E +K++ +
Sbjct: 604 NLVDYSIT--HAEPANVFDINSHTGEIWLKNSIR 635
Score = 68.1 bits (159), Expect = 2e-10
Identities = 43/145 (29%), Positives = 71/145 (48%), Gaps = 8/145 (5%)
Query: 241 RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLN 300
R +FS+D G++ L +ELD + E ++A +++ L +V I + D N
Sbjct: 77 RSVFSVDPTFGNITLVEELDREREDEIEA--------IISISDGLNLVAEKVVILVTDAN 128
Query: 301 DNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGW 360
D P F + Y + E++P G + +V A D+D G G TY L + F++D SG
Sbjct: 129 DEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAVDRHSGV 188
Query: 361 LTVRNQTVLDREAHSSLRMKVYAKE 385
L ++ LD E + + V AK+
Sbjct: 189 LRLQAGATLDYERSRTHYITVVAKD 213
Score = 67.3 bits (157), Expect = 4e-10
Identities = 110/466 (23%), Positives = 195/466 (41%), Gaps = 50/466 (10%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V + D D PVFV + Y + + G+ + KV A+D D G+ +LY L ++
Sbjct: 231 VTVNVEDVQDMAPVFVGTPYYGYVYEDTLP-GSEVLKVVAMDGDRGKPNRILYSLVNGND 289
Query: 505 LTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRGTK 564
F+IN +G +S+ +SP R + +P+ + A V + +
Sbjct: 290 ----GAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDL 345
Query: 565 GNKPDIPDFMGAP-----YEFWVGSNVGIGTSVG--QIRVNDAFEQNDVSYDLL----HG 613
N P P F G +E + + G + +I VND+ + + ++L G
Sbjct: 346 NNHP--PTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRG 403
Query: 614 YEEGVPFAVEERSGVITVVDDLSRYN---RPMYDFEAVALQENA--NLSIVTNATVHVVD 668
VP V + V +V++ + + + F+ +A++ N S + + ++D
Sbjct: 404 IFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLD 463
Query: 669 VNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTD 728
ND + K + + EN+ G + + T + G G V++ + D
Sbjct: 464 TNDN---VPKFDSLYYVARIPENAPGGS-SVVAVTAVDPDTGPW-GEVKY--STYGTGAD 516
Query: 729 DIAI-AEDGTIFTQK--PLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP 785
I G I+TQ LD E Y V AE +G S A ++ I + D ND+PP
Sbjct: 517 LFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYSVAEVF---ITLLDVNDHPP 573
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGV 845
F + + ++ +GT +K++ I + DA+E N + E +FD++ +TG
Sbjct: 574 QFGKSVQKKTMV----LGTPVKIEAIDE--DAEEPNNLVDYSITHAEPANVFDINSHTGE 627
Query: 846 V--KFIGDSLDREKKI------MYKLSLVARDTGGLSSEAELIIMI 883
+ K SLD I ++ L + A+D G S ++ I
Sbjct: 628 IWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKI 673
Score = 66.5 bits (155), Expect = 7e-10
Identities = 54/194 (27%), Positives = 92/194 (47%), Gaps = 23/194 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G + Y L++GND F ++ +G++ + + + LQ + L VQ +
Sbjct: 269 AMDGDRGKPNRILYSLVNGNDGA-FEINETSGAISITQ-----SPAQLQREVYELHVQVT 322
Query: 280 QLN---NPLKTAQARVEIELLDLNDNLPEF-----EVDFYNISIVENLPNG--FSVLQVM 329
+++ +P A V I ++DLN++ P F + + +S+ E+ P G L++
Sbjct: 323 EMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKIT 382
Query: 330 ATDKDQGENGEFTYQLDDPKGAFSIDPRS------GWLTVRNQTVLDREAHSSLRMKVYA 383
D DQG N +F QL P+G F + P++ + V N +D E L K+ A
Sbjct: 383 VNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLA 442
Query: 384 KETN-PSVVGTFAD 396
E N P + AD
Sbjct: 443 VEVNTPEKFSSTAD 456
Score = 64.9 bits (151), Expect = 2e-09
Identities = 107/470 (22%), Positives = 192/470 (40%), Gaps = 50/470 (10%)
Query: 454 DNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKI 513
DN N+ FS+ + VG+ + + DP+ + Y + + + + S F +
Sbjct: 28 DNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPE---GDPISYHI--SFDPSTRSVFSV 82
Query: 514 NPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRGTKGNKPDIPDF 573
+P G +++ E L+ +EA ++ L +V +V + P F
Sbjct: 83 DPTFGNITLVEE--LDREREDEIEAIISISD------GLNLVAEKVVILVTDANDEAPRF 134
Query: 574 MGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITV 631
+ PY V ++ G+ + ++ D V+Y L + + PFAV+ SGV+ +
Sbjct: 135 IQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHS---PFAVDRHSGVLRL 191
Query: 632 VDDLSR-YNRPMYDFEAVALQENAN--------LSIVTNATVHVVDVNDERGVLLKGAHS 682
+ Y R + V ++ S T TV+V DV D V + +
Sbjct: 192 QAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYY 251
Query: 683 PIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQK 742
++ ++ G+ + ++ M G + + + N D +I TQ
Sbjct: 252 GYVY--EDTLPGSEVLKV--VAMDGDRGK-PNRILYSLVNGNDGAFEINETSGAISITQS 306
Query: 743 PLDREKRDVYRMTV-IAEFNK-GVISGAGIYQVTIYIEDENDNPPVFEHAT-----YEGF 795
P + R+VY + V + E + G + VTI I D N++PP F + +E
Sbjct: 307 PAQLQ-REVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELS 365
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDE---NTGVVKFIGDS 852
+ E+ G EI I D+D+G NA F L G V + N V I ++
Sbjct: 366 MNEHPPQG-EILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVEN 424
Query: 853 -----LDREKKIMYKLSLVARDTGG-LSSEAELIIMIGDENDNKPEFNQI 896
++ K + +KL V +T SS A+++I + D NDN P+F+ +
Sbjct: 425 SAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSL 474
Score = 64.5 bits (150), Expect = 3e-09
Identities = 59/194 (30%), Positives = 86/194 (44%), Gaps = 22/194 (11%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
LF +PE+ P+G+ + LN D + I Y + + PS S F ++
Sbjct: 40 LFSLPEDTPVGSHVYTLNGTDPEGD---PISYHISFD----PSTRSV--------FSVDP 84
Query: 997 RHGHVIVARSLPPESEFRLN--ISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNV 1054
G++ + L E E + IS DG NL V + V D ND P F + Y V
Sbjct: 85 TFGNITLVEELDREREDEIEAIISISDGLNLVAE-KVVILVTDANDEAPRFIQEPYVALV 143
Query: 1055 EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGV--LSVNGELDRET 1112
E ++ KV A D D G ++TYF+Q + PF + +GV L LD E
Sbjct: 144 PEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQ--NLHSPFAVDRHSGVLRLQAGATLDYER 201
Query: 1113 EDKYILTVVARDNG 1126
+ +TVVA+D G
Sbjct: 202 SRTHYITVVAKDGG 215
Score = 58.4 bits (135), Expect = 2e-07
Identities = 63/248 (25%), Positives = 107/248 (43%), Gaps = 12/248 (4%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN A +I V N A Q + L+PE+IP G+ I K++A+D D+G G + Y
Sbjct: 113 LNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTY- 171
Query: 970 FNSEVYIPPS-KLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDN 1028
F ++ P + + L ++ ++ + + RL+ + + +
Sbjct: 172 FLQNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVV---FSAT 228
Query: 1029 ISVRVFVKDVNDHFPVFKKT-WYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
+V V V+DV D PVF T +Y + E+ VL KV A D D G+ + Y + +
Sbjct: 229 TTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVL-KVVAMDGDRGKPNRILYSL-VN 286
Query: 1088 DTDLPFEISPLTGVLSVN---GELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDV 1144
D FEI+ +G +S+ +L RE + ++ V D+
Sbjct: 287 GNDGAFEINETSGAISITQSPAQLQREVYELHV-QVTEMSPAGSPAAQATVPVTIRIVDL 345
Query: 1145 NDNSPKFY 1152
N++ P FY
Sbjct: 346 NNHPPTFY 353
Score = 56.8 bits (131), Expect = 6e-07
Identities = 53/197 (26%), Positives = 92/197 (46%), Gaps = 10/197 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHN-LQANTFVLQV 276
+HA+D+D G G ++ Y L N F++D +G L L+ LD E + T V +
Sbjct: 156 VHAVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKD 213
Query: 277 QASQLNNP--LKTAQARVEIELLDLNDNLPEFE-VDFYNISIVENLPNGFSVLQVMATDK 333
+L+ + +A V + + D+ D P F +Y + LP G VL+V+A D
Sbjct: 214 GGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLP-GSEVLKVVAMDG 272
Query: 334 DQGENGEFTYQL-DDPKGAFSIDPRSGWLTV-RNQTVLDREAHS-SLRMKVYAKETNPSV 390
D+G+ Y L + GAF I+ SG +++ ++ L RE + +++ + +P+
Sbjct: 273 DRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAA 332
Query: 391 VGTFADSQRIAKWRRQP 407
T + RI P
Sbjct: 333 QATVPVTIRIVDLNNHP 349
Score = 50.4 bits (115), Expect = 5e-05
Identities = 61/199 (30%), Positives = 86/199 (43%), Gaps = 25/199 (12%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E+ S +V + LLD NDN P F S Y + NA G+ + V AVDPD G G V
Sbjct: 449 EKFSSTADVVIQLLDTNDNVPKF-DSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVK 507
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILE----GRHALFVEASDQPANPSERRYSL 552
Y T F I+P+TG + L+ R+ +V+A D E +YS+
Sbjct: 508 YSTYGTG----ADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDM-----EGKYSV 558
Query: 553 AVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN-DAFEQND-VSYDL 610
A V I T + D P G + + +GT V ++ DA E N+ V Y +
Sbjct: 559 AEVFI-----TLLDVNDHPPQFGKSVQ---KKTMVLGTPVKIEAIDEDAEEPNNLVDYSI 610
Query: 611 LHGYEEGVPFAVEERSGVI 629
H V F + +G I
Sbjct: 611 THAEPANV-FDINSHTGEI 628
Score = 37.1 bits (82), Expect = 0.48
Identities = 19/56 (33%), Positives = 27/56 (48%), Gaps = 2/56 (3%)
Query: 62 DEGDDLVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAF 117
DE + ++ I GLN ++ V + + D ND P F+ PY V E P G F
Sbjct: 101 DEIEAIISISDGLNLVAE--KVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIF 154
Score = 36.7 bits (81), Expect = 0.64
Identities = 18/38 (47%), Positives = 24/38 (63%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEK 115
SA +VTV +EDV D P+F+ TPY+ V E T G +
Sbjct: 226 SATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSE 263
>BC093815-1|AAH93815.1| 1135|Homo sapiens protocadherin 18 protein.
Length = 1135
Score = 106 bits (254), Expect = 7e-22
Identities = 123/473 (26%), Positives = 189/473 (39%), Gaps = 32/473 (6%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E L F ++EV +LD NDN+P F S L + +A VGT I A DPD+G+N +
Sbjct: 116 EHLQLF-HIEVEVLDINDNSPQFSRS-LIPIEISESAAVGTRIPLDSAFDPDVGENSLHT 173
Query: 497 YDLQRTS--NLTITSPFKINPNTGTVSVAE-SPILEGRHALFVEASDQPANPSERRYSLA 553
Y L N+ + + + V E L+ + L + ASD +R +
Sbjct: 174 YSLSANDFFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGV---PQRSGSS 230
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLL 611
++ I ++ + P F Y + N +GT + + D E + Y
Sbjct: 231 ILKISISDSNDNS----PAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFS 286
Query: 612 HGYEEGV--PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVD 668
+ F ++ G +T+ + Y+ + A N + + VVD
Sbjct: 287 SHVSPKIMETFKIDSERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVD 346
Query: 669 VNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNG-TGNVRFLIANQQDVT 727
VND + + SP + G I +G G + +
Sbjct: 347 VNDNKPEININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFK 406
Query: 728 DDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVF 787
+ I T LDREKR Y +TVIAE ++G S + + T+ I D NDNPP F
Sbjct: 407 LQKTYENNYLILTNATLDREKRSEYSLTVIAE-DRGTPSLSTVKHFTVQINDINDNPPHF 465
Query: 788 EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL---FGEGKEM---FDVDE 841
+ + YE I EN+ G I + ATD D G N YT+ F G + +D
Sbjct: 466 QRSRYEFVISENNSPGAYI---TTVTATDPDLGENGQVTYTILESFILGSSITTYVTIDP 522
Query: 842 NTGVVKFIGDSLDREKKIMYKLSLVARDTGG---LSSEAELIIMIGDENDNKP 891
+ G + + D E+ + ARD G L S +++ I DENDN P
Sbjct: 523 SNGAIYALR-IFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVP 574
Score = 92.7 bits (220), Expect = 9e-18
Identities = 109/454 (24%), Positives = 192/454 (42%), Gaps = 30/454 (6%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
+++++ D+NDN+P F + Y + N+ VGT++ + A DPD G NG ++Y +
Sbjct: 232 LKISISDSNDNSPAFEQQS-YIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVS 290
Query: 505 LTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
I FKI+ G +++ + E + + V+A D N + + ++V
Sbjct: 291 PKIMETFKIDSERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDV--- 347
Query: 563 TKGNKPDIPDFMGAPYE---FWVGSNVGIGTSVGQIRVNDAFE-QNDVSYDLLHGYEEGV 618
NKP+I + +P + ++ I T V +RV D N LHG+
Sbjct: 348 -NDNKPEININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFK 406
Query: 619 PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLL 677
E + +I L R R Y +A +LS V + TV + D+ND
Sbjct: 407 LQKTYENNYLILTNATLDREKRSEYSLTVIAEDRGTPSLSTVKHFTVQINDINDNPPHFQ 466
Query: 678 KGAHSPIIFHVKENSAGAAIGQIFHTNMS-SIYGNGTGNVRFLIANQQDVTDDIAI-AED 735
+ + +I + NS GA I + T+ G T + +T + I +
Sbjct: 467 RSRYEFVI--SENNSPGAYITTVTATDPDLGENGQVTYTILESFILGSSITTYVTIDPSN 524
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIY--IEDENDNPPV-----FE 788
G I+ + D E +V ++T + E G + T+ I DENDN PV
Sbjct: 525 GAIYALRIFDHE--EVSQITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVPVVIGPALR 582
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNA-LFMYTLFGEGKEMFDVDENTGVVK 847
+ T E I + ++ G + I+A D D G NA L + G + +F +D + +
Sbjct: 583 NNTAEITIPKGAESGFHVTR---IRAIDRDSGVNAELSCAIVAGNEENIFIIDPRSCDI- 638
Query: 848 FIGDSLDREKKIMYKLSLVARDTGGLSSEAELII 881
S+D ++LS++ +D G ++++
Sbjct: 639 HTNVSMDSVPYTEWELSVIIQDKGNPQLHTKVLL 672
Score = 80.2 bits (189), Expect = 5e-14
Identities = 54/168 (32%), Positives = 84/168 (50%), Gaps = 11/168 (6%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
A+ + + LDRE + Y + + A + GV +G + I I D NDN P FE +Y
Sbjct: 193 AKYAELIVVRELDRELKSSYELQLTAS-DMGVPQRSGSSILKISISDSNDNSPAFEQQSY 251
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGK----EMFDVDENTGVVKF 848
++ENS +GT + +D + ATD DEG N +Y+ E F +D G +
Sbjct: 252 IIQLLENSPVGT-LLLD--LNATDPDEGANGKIVYSFSSHVSPKIMETFKIDSERGHLTL 308
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFN 894
+D E Y++ + A+D G + + ++II + D NDNKPE N
Sbjct: 309 F-KQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEIN 355
Score = 77.8 bits (183), Expect = 3e-13
Identities = 52/177 (29%), Positives = 88/177 (49%), Gaps = 8/177 (4%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D+G + Y L + + + +G+ + E + + + L+++ + LQ+ AS
Sbjct: 161 AFDPDVGENSLHTYSLSANDFFNIEVRTRTDGAKYAELIVVRELDRELKSS-YELQLTAS 219
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
+ P ++ + ++I + D NDN P FE Y I ++EN P G +L + ATD D+G NG
Sbjct: 220 DMGVPQRSGSSILKISISDSNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANG 279
Query: 340 EFTYQLD---DPK--GAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVV 391
+ Y PK F ID G LT+ Q +D E S + V A++ P+ +
Sbjct: 280 KIVYSFSSHVSPKIMETFKIDSERGHLTLFKQ--VDYEITKSYEIDVQAQDLGPNSI 334
Score = 70.1 bits (164), Expect = 6e-11
Identities = 61/243 (25%), Positives = 99/243 (40%), Gaps = 21/243 (8%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
I + N + +Q + + EN P+GT ++ LNA D D G NG+I Y F+S V
Sbjct: 234 ISISDSNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHV---- 289
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG--NLNDNISVRVF 1034
+ ++ F I+ GH+ + + + E + +++ A D G ++ + + +
Sbjct: 290 ------SPKIMETFKIDSERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIK 343
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQY------TRRVLGKVDATDADFGQNANLTYFIQPSD 1088
V DVND+ P + EE Y + V D D G N + +
Sbjct: 344 VVDVNDNKPEININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHG 403
Query: 1089 TDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
+ ++ N LDRE +Y LTV+A D G D+NDN
Sbjct: 404 HFKLQKTYENNYLILTNATLDREKRSEYSLTVIAEDRG-TPSLSTVKHFTVQINDINDNP 462
Query: 1149 PKF 1151
P F
Sbjct: 463 PHF 465
Score = 68.9 bits (161), Expect = 1e-10
Identities = 109/442 (24%), Positives = 182/442 (41%), Gaps = 57/442 (12%)
Query: 929 LDVDQLGPLF---LIP----ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD++ P F LIP E+ +GT I +A D D G N Y ++ +
Sbjct: 128 LDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSANDFFN---- 183
Query: 982 SADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG--NLNDNISVRVFVKD 1037
+EV R ++ +IV R L E S + L ++A D G + + +++ + D
Sbjct: 184 ----IEV-RTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGVPQRSGSSILKISISD 238
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY----FIQPSDTDLPF 1093
ND+ P F++ Y + E +L ++ATD D G N + Y + P + F
Sbjct: 239 SNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIME-TF 297
Query: 1094 EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYA 1153
+I G L++ ++D E Y + V A+D G DVNDN P+
Sbjct: 298 KIDSERGHLTLFKQVDYEITKSYEIDVQAQDLG-PNSIPAHCKIIIKVVDVNDNKPEIN- 355
Query: 1154 FDELLEWKHPEADELSNHNFES---VMMIPVYKATIEENAPIGTTVAKVFAN---DTDFI 1207
+ P +E+S + FE + + + +++ G V K+ +
Sbjct: 356 ----INLMSPGKEEIS-YIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKT 410
Query: 1208 GNGNGLILYSLP---QRKNQQNL-------GLPSLSSTAILMVTVADVPDEVEMSDKPVF 1257
N LIL + +++++ +L G PSLS+ V + D+ D + P F
Sbjct: 411 YENNYLILTNATLDREKRSEYSLTVIAEDRGTPSLSTVKHFTVQINDIND-----NPPHF 465
Query: 1258 ISRYYELEIEENVNAPVELVSLNLTEH--YENFKMRYYILNE--NDTDIRRTFVIDPRNG 1313
YE I EN + + ++ T+ EN ++ Y IL + I IDP NG
Sbjct: 466 QRSRYEFVISENNSPGAYITTVTATDPDLGENGQVTYTILESFILGSSITTYVTIDPSNG 525
Query: 1314 TLYLVRSPDREVKDTYEVIVRA 1335
+Y +R D E +V A
Sbjct: 526 AIYALRIFDHEEVSQITFVVEA 547
Score = 67.7 bits (158), Expect = 3e-10
Identities = 59/189 (31%), Positives = 86/189 (45%), Gaps = 13/189 (6%)
Query: 716 VRFLIANQQDVTDDIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKGVI--SGAGIYQ 772
VRF A Q+ + + + ED G I +DRE+ + EF+ + ++
Sbjct: 64 VRFR-AMQRGNSPLLVVNEDNGEISIGATIDREQLCQKNLNCSIEFDVITLPTEHLQLFH 122
Query: 773 VTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGE 832
+ + + D NDN P F + I E++ +GT I +D+ A D D G N+L Y+L
Sbjct: 123 IEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDS---AFDPDVGENSLHTYSLSAN 179
Query: 833 GKEMFDVDENTGVVKF----IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDE 886
+V T K+ + LDRE K Y+L L A D G S + L I I D
Sbjct: 180 DFFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGVPQRSGSSILKISISDS 239
Query: 887 NDNKPEFNQ 895
NDN P F Q
Sbjct: 240 NDNSPAFEQ 248
Score = 66.1 bits (154), Expect = 9e-10
Identities = 61/236 (25%), Positives = 92/236 (38%), Gaps = 22/236 (9%)
Query: 925 NKFALDVDQLGP----LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSK 980
NK ++++ + P + I E PI T + + D DSGLNG+I + + + K
Sbjct: 350 NKPEININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQK 409
Query: 981 LSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGG--NLNDNISVRVFVKDV 1038
+ Y ++ SE+ L + A D G +L+ V + D+
Sbjct: 410 TYEN-----NYLILTN------ATLDREKRSEYSLTVIAEDRGTPSLSTVKHFTVQINDI 458
Query: 1039 NDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-----FIQPSDTDLPF 1093
ND+ P F+++ Y F + E + V ATD D G+N +TY FI S
Sbjct: 459 NDNPPHFQRSRYEFVISENNSPGAYITTVTATDPDLGENGQVTYTILESFILGSSITTYV 518
Query: 1094 EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
I P G + D E + V ARD G D NDN P
Sbjct: 519 TIDPSNGAIYALRIFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVP 574
Score = 59.3 bits (137), Expect = 1e-07
Identities = 74/299 (24%), Positives = 118/299 (39%), Gaps = 42/299 (14%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGE----------------KA 116
G+ Q S + + I D NDN P F Y + + E +P G K
Sbjct: 222 GVPQRSGSSILKISISDSNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKI 281
Query: 117 FIFLIAPIGPSL--TIPLTVPRG-LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFA 173
+ + P + T + RG LT+FK + D T + ++ V D G +
Sbjct: 282 VYSFSSHVSPKIMETFKIDSERGHLTLFKQV-----DYEITKSYEID---VQAQDLGPNS 333
Query: 174 LESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI-------DQDLG 226
+ + K ++ KV+D + E + +M+ GK I +PI D+D G
Sbjct: 334 IPAHCKIII---KVVDVNDNKPEININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSG 390
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLK 286
+ + +L KL N + LD + + + + L V A P
Sbjct: 391 LNGEIVCKLHGHGHFKLQKTYENNYLILTNATLDRE-----KRSEYSLTVIAEDRGTPSL 445
Query: 287 TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+ +++ D+NDN P F+ Y I EN G + V ATD D GENG+ TY +
Sbjct: 446 STVKHFTVQINDINDNPPHFQRSRYEFVISENNSPGAYITTVTATDPDLGENGQVTYTI 504
Score = 58.8 bits (136), Expect = 1e-07
Identities = 123/575 (21%), Positives = 219/575 (38%), Gaps = 66/575 (11%)
Query: 571 PDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGV 628
P F + + + +GT +I ++ AF+ DV + LH Y F +E R+
Sbjct: 135 PQFSRSLIPIEISESAAVGT---RIPLDSAFDP-DVGENSLHTYSLSANDFFNIEVRTRT 190
Query: 629 -------ITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAH 681
+ VV +L R + Y+ + A + + + +++ + ++D
Sbjct: 191 DGAKYAELIVVRELDRELKSSYELQLTA--SDMGVPQRSGSSILKISISDSNDNSPAFEQ 248
Query: 682 SPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFT 740
I + ENS + + NG F + + I +E G +
Sbjct: 249 QSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIMETFKIDSERGHLTL 308
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP-----VFEHATYE-G 794
K +D E Y + V A+ + G S ++ I + D NDN P + E
Sbjct: 309 FKQVDYEITKSYEIDVQAQ-DLGPNSIPAHCKIIIKVVDVNDNKPEININLMSPGKEEIS 367
Query: 795 FIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLD 854
+I E I T + + ++ D D G N + L G G + +LD
Sbjct: 368 YIFEGDPIDTFVAL---VRVQDKDSGLNGEIVCKLHGHGHFKLQKTYENNYLILTNATLD 424
Query: 855 REKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNG 912
REK+ Y L+++A D G LS+ + I D NDN P F + + E G
Sbjct: 425 REKRSEYSLTVIAEDRGTPSLSTVKHFTVQINDINDNPPHFQRSRYEFVI---SENNSPG 481
Query: 913 TAGFTIIEVKPKNKFALDVDQLGPL-FLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
T+ P D+ + G + + I E+ +G++I +D +G +R +
Sbjct: 482 AYITTVTATDP------DLGENGQVTYTILESFILGSSITTYVTIDPSNGAIYALRIFDH 535
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISV 1031
EV S+++ FV+ R G + L + L I +D NDN+ V
Sbjct: 536 EEV----SQIT---------FVVEARDGG--SPKQLVSNTTVVLTI--IDE---NDNVPV 575
Query: 1032 RVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDL 1091
+ P + + + + + ++ A D D G NA L+ I + +
Sbjct: 576 VI--------GPALRNNTAEITIPKGAESGFHVTRIRAIDRDSGVNAELSCAIVAGNEEN 627
Query: 1092 PFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
F I P + + N +D ++ L+V+ +D G
Sbjct: 628 IFIIDPRSCDIHTNVSMDSVPYTEWELSVIIQDKG 662
Score = 54.8 bits (126), Expect = 2e-06
Identities = 42/156 (26%), Positives = 73/156 (46%), Gaps = 24/156 (15%)
Query: 1226 NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHY 1285
++G+P S ++IL ++++D D + P F + Y +++ EN L+ LN T+
Sbjct: 220 DMGVPQRSGSSILKISISDSND-----NSPAFEQQSYIIQLLENSPVGTLLLDLNATDPD 274
Query: 1286 E--NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRE 1343
E N K+ Y + I TF ID G L L + D E+ +YE+ V+
Sbjct: 275 EGANGKIVYSFSSHVSPKIMETFKIDSERGHLTLFKQVDYEITKSYEIDVQ--------- 325
Query: 1344 LPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPK 1379
A+D+ K+++++ DVNDN P+
Sbjct: 326 --------AQDLGPNSIPAHCKIIIKVVDVNDNKPE 353
Score = 49.6 bits (113), Expect = 8e-05
Identities = 43/163 (26%), Positives = 73/163 (44%), Gaps = 10/163 (6%)
Query: 229 ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTA 288
+T+R+ + + L ++ NG + + +D E Q N ++ + P +
Sbjct: 62 STVRFRAMQRGNSPLLVVNEDNGEISIGATID--REQLCQKN-LNCSIEFDVITLPTEHL 118
Query: 289 QA-RVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD 347
Q +E+E+LD+NDN P+F I I E+ G + A D D GEN TY L
Sbjct: 119 QLFHIEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSL-S 177
Query: 348 PKGAFSIDPRSGWLTVRNQTV-----LDREAHSSLRMKVYAKE 385
F+I+ R+ + + LDRE SS +++ A +
Sbjct: 178 ANDFFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASD 220
Score = 46.8 bits (106), Expect = 6e-04
Identities = 45/171 (26%), Positives = 69/171 (40%), Gaps = 14/171 (8%)
Query: 993 VINERHGHVIVARSLPPESEFRLNISA---LDGGNLNDN----ISVRVFVKDVNDHFPVF 1045
V+NE +G + + ++ E + N++ D L + V V D+ND+ P F
Sbjct: 78 VVNEDNGEISIGATIDREQLCQKNLNCSIEFDVITLPTEHLQLFHIEVEVLDINDNSPQF 137
Query: 1046 KKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLT-----G 1100
++ + E+ + A D D G+N+ TY + +D E+ T
Sbjct: 138 SRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSANDF-FNIEVRTRTDGAKYA 196
Query: 1101 VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
L V ELDRE + Y L + A D G D NDNSP F
Sbjct: 197 ELIVVRELDRELKSSYELQLTASDMG-VPQRSGSSILKISISDSNDNSPAF 246
Score = 44.8 bits (101), Expect = 0.002
Identities = 38/153 (24%), Positives = 71/153 (46%), Gaps = 16/153 (10%)
Query: 218 IHAIDQDLGVGATLRYELIS----GNDRKLF-SLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A D DLG + Y ++ G+ + ++D NG+++ + D + + TF
Sbjct: 487 VTATDPDLGENGQVTYTILESFILGSSITTYVTIDPSNGAIYALRIFDHEEVSQI---TF 543
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLP-----EFEVDFYNISIVENLPNGFSVLQ 327
V++ + L + V + ++D NDN+P + I+I + +GF V +
Sbjct: 544 VVEARDGGSPKQL-VSNTTVVLTIIDENDNVPVVIGPALRNNTAEITIPKGAESGFHVTR 602
Query: 328 VMATDKDQGENGEFTYQL--DDPKGAFSIDPRS 358
+ A D+D G N E + + + + F IDPRS
Sbjct: 603 IRAIDRDSGVNAELSCAIVAGNEENIFIIDPRS 635
>BC045637-1|AAH45637.1| 795|Homo sapiens protocadherin beta 12
protein.
Length = 795
Score = 106 bits (254), Expect = 7e-22
Identities = 117/468 (25%), Positives = 202/468 (43%), Gaps = 42/468 (8%)
Query: 442 FVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQR 501
F+ +E+ + D ND++PVF+ + + N+ VG V A D D+G N + Y +
Sbjct: 116 FLQIELQVRDINDHSPVFLEKEML-LEIPENSPVGAVFLLESAKDLDVGINAVKSYTINP 174
Query: 502 TSNLTITSPFKINPNTGTVS--VAESPI-LEGRHAL--FVEASDQPANPSERRYSLAVVT 556
S+ + ++NP+ V + + E R L + A D + P + VV
Sbjct: 175 NSHFHVK--IRVNPDNRKYPELVLDKALDYEERPELSFILTALDGGSPPRSGTALVRVVV 232
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGY 614
+++ + P+F A YE + N +G+ V + D+ +++SY H
Sbjct: 233 VDINDNS-------PEFEQAFYEVKILENSILGSLVVTVSAWDLDSGTNSELSYTFSHAS 285
Query: 615 EE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDER 673
E+ F + ++SG IT+ L Y + + L + + V+DVND
Sbjct: 286 EDIRKTFEINQKSGDITLTAPLDFEAIESYSI-IIQATDGGGLFGKSTVRIQVMDVNDNA 344
Query: 674 GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIA 733
+ S I + EN+ + +F NG + + + +D+ + +
Sbjct: 345 PEITV---SSITSPIPENTPETVV-MVFRIRDRDSGDNG----KMVCSIPEDIPFVLKSS 396
Query: 734 EDG--TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
+ T+ T++PLDRE R Y +T+ + G + +T+ + D NDN P F +
Sbjct: 397 VNNYYTLETERPLDRESRAEYNITITVT-DLGTPRLKTEHNITVLVSDVNDNAPAFTQTS 455
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDENTGV 845
Y F+ EN+ I I ATD D GTNA Y+L + ++ + G
Sbjct: 456 YALFVRENNSPALHI---GSISATDRDSGTNAQVNYSLLPSQDPHLPLASLVSINADNGH 512
Query: 846 VKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
+ F SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 513 L-FALRSLDYEALQGFQFRVGATDHGSPALSSEALVRVLVLDANDNSP 559
Score = 101 bits (241), Expect = 3e-20
Identities = 130/513 (25%), Positives = 214/513 (41%), Gaps = 76/513 (14%)
Query: 930 DVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLS 982
D++ P+FL IPEN P+G + +A DLD G+N Y N P S
Sbjct: 125 DINDHSPVFLEKEMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTIN-----PNSHFH 179
Query: 983 ADALEVKRYFVINERHGHVIVARSLPPESEFRLN--ISALDGGN--LNDNISVRVFVKDV 1038
R N ++ +++ ++L E L+ ++ALDGG+ + VRV V D+
Sbjct: 180 VKI----RVNPDNRKYPELVLDKALDYEERPELSFILTALDGGSPPRSGTALVRVVVVDI 235
Query: 1039 NDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDL--PFEIS 1096
ND+ P F++ +Y + E ++ V A D D G N+ L+Y + D+ FEI+
Sbjct: 236 NDNSPEFEQAFYEVKILENSILGSLVVTVSAWDLDSGTNSELSYTFSHASEDIRKTFEIN 295
Query: 1097 PLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF--YAF 1154
+G +++ LD E + Y + + A D G DVNDN+P+ +
Sbjct: 296 QKSGDITLTAPLDFEAIESYSIIIQATDGG---GLFGKSTVRIQVMDVNDNAPEITVSSI 352
Query: 1155 DELLEWKHPEA--------DELSNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDT 1204
+ PE D S N + V IP E+ P + ++V + +T
Sbjct: 353 TSPIPENTPETVVMVFRIRDRDSGDNGKMVCSIP-------EDIPFVLKSSVNNYYTLET 405
Query: 1205 DFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYEL 1264
+ + Y++ +LG P L + + V V+DV D + P F Y L
Sbjct: 406 ERPLDRESRAEYNI--TITVTDLGTPRLKTEHNITVLVSDVND-----NAPAFTQTSYAL 458
Query: 1265 EIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRS 1320
+ EN + + + S++ T+ N ++ Y +L D + + I+ NG L+ +RS
Sbjct: 459 FVRENNSPALHIGSISATDRDSGTNAQVNYSLLPSQDPHLPLASLVSINADNGHLFALRS 518
Query: 1321 PDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP-- 1378
D E ++ V A H ++ + L V V + D NDNSP
Sbjct: 519 LDYEALQGFQFRVGA--------TDHGSPALSSEAL---------VRVLVLDANDNSPFV 561
Query: 1379 --KFTNGNRPLVTAIPTTAPFGYQVMQLKGAIG 1409
NG+ P +P A GY V ++ G
Sbjct: 562 LYPLQNGSAPCTELVPWAAEPGYLVTKVVAVDG 594
Score = 75.4 bits (177), Expect = 1e-12
Identities = 78/323 (24%), Positives = 143/323 (44%), Gaps = 30/323 (9%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLIAN 722
+ V D+ND V L+ ++ + ENS +G +F + G V+ + I
Sbjct: 121 LQVRDINDHSPVFLE---KEMLLEIPENSP---VGAVFLLESAKDLDVGINAVKSYTINP 174
Query: 723 QQDVTDDIAIAEDGTIFTQ----KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIE 778
I + D + + K LD E+R ++ + G +G V + +
Sbjct: 175 NSHFHVKIRVNPDNRKYPELVLDKALDYEERPELSF-ILTALDGGSPPRSGTALVRVVVV 233
Query: 779 DENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM-- 836
D NDN P FE A YE I+ENS +G+ + + A D D GTN+ YT +++
Sbjct: 234 DINDNSPEFEQAFYEVKILENSILGSLVV---TVSAWDLDSGTNSELSYTFSHASEDIRK 290
Query: 837 -FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQ 895
F++++ +G + LD E Y + + A D GGL ++ + I + D NDN PE
Sbjct: 291 TFEINQKSGDITLTA-PLDFEAIESYSIIIQATDGGGLFGKSTVRIQVMDVNDNAPEITV 349
Query: 896 IEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIP--IGTTIIKL 953
S + T ++ + +++ + D ++ + IPE+IP + +++
Sbjct: 350 SSITSPIP-------ENTPETVVMVFRIRDRDSGDNGKM--VCSIPEDIPFVLKSSVNNY 400
Query: 954 NALDLDSGLNGQIRYEFNSEVYI 976
L+ + L+ + R E+N + +
Sbjct: 401 YTLETERPLDRESRAEYNITITV 423
Score = 70.1 bits (164), Expect = 6e-11
Identities = 85/324 (26%), Positives = 137/324 (42%), Gaps = 29/324 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTP-TGEKAFIFLIAPIGPS----LTIPLTVPR 136
+V + + DVNDN P + + E TP T F G + +IP +P
Sbjct: 332 TVRIQVMDVNDNAPEITVSSITSPIPENTPETVVMVFRIRDRDSGDNGKMVCSIPEDIPF 391
Query: 137 GL-TIFKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
L + + + ++P S Y+I ++ D G L++ H +L+ V D
Sbjct: 392 VLKSSVNNYYTLETERPLDRESRAEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPAF 451
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLFSLDSV 249
+ + + + L I A D+D G A + Y L+ D L S+++
Sbjct: 452 TQTSYALFV--RENNSPALHIGSISATDRDSGTNAQVNYSLLPSQDPHLPLASLVSINAD 509
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
NG LF + LD +A LQ F +V A+ +P +++A V + +LD NDN P
Sbjct: 510 NGHLFALRSLDYEA---LQG--FQFRVGATDHGSPALSSEALVRVLVLDANDNSPFVLYP 564
Query: 310 FYNISI--VENLP----NGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWL 361
N S E +P G+ V +V+A D D G+N +YQL G F + +G
Sbjct: 565 LQNGSAPCTELVPWAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG-- 622
Query: 362 TVRNQTVLDREAHSSLRMKVYAKE 385
VR +L + R+ V K+
Sbjct: 623 EVRTARLLSERDAAKHRLVVLVKD 646
Score = 65.7 bits (153), Expect = 1e-09
Identities = 47/137 (34%), Positives = 71/137 (51%), Gaps = 11/137 (8%)
Query: 253 LFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN 312
L L+K LD + L +F+L A +P ++ A V + ++D+NDN PEFE FY
Sbjct: 194 LVLDKALDYEERPEL---SFILT--ALDGGSPPRSGTALVRVVVVDINDNSPEFEQAFYE 248
Query: 313 ISIVENLPNGFSVLQVMATDKDQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTV 368
+ I+EN G V+ V A D D G N E +Y +D + F I+ +SG +T+
Sbjct: 249 VKILENSILGSLVVTVSAWDLDSGTNSELSYTFSHASEDIRKTFEINQKSGDITL--TAP 306
Query: 369 LDREAHSSLRMKVYAKE 385
LD EA S + + A +
Sbjct: 307 LDFEAIESYSIIIQATD 323
Score = 62.9 bits (146), Expect = 9e-09
Identities = 69/319 (21%), Positives = 130/319 (40%), Gaps = 30/319 (9%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLT 139
+L + + + D+ND+ P+FL+ + + E +P G +FL+ L + + + T
Sbjct: 116 FLQIELQVRDINDHSPVFLEKEMLLEIPENSPVGA---VFLLES-AKDLDVGINAVKSYT 171
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGH---------FALESSHKP----VLLLRK 186
I + + + N N ++ D AL+ P L+
Sbjct: 172 INPNSHFHVKIRVNPDNRKYPELVLDKALDYEERPELSFILTALDGGSPPRSGTALVRVV 231
Query: 187 VLDYDAGDKEFQLVIMASGKRIHKEIL--FPEPIHAIDQDLGVGATLRYELISGND--RK 242
V+D + EF+ K + IL + A D D G + L Y ++ RK
Sbjct: 232 VVDINDNSPEFEQAFYEV-KILENSILGSLVVTVSAWDLDSGTNSELSYTFSHASEDIRK 290
Query: 243 LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDN 302
F ++ +G + L LD +A ++ + +QA+ ++ V I+++D+NDN
Sbjct: 291 TFEINQKSGDITLTAPLDFEA-----IESYSIIIQATDGGGLF--GKSTVRIQVMDVNDN 343
Query: 303 LPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLT 362
PE V I EN P V+ D+D G+NG+ + + + + T
Sbjct: 344 APEITVSSITSPIPENTPETV-VMVFRIRDRDSGDNGKMVCSIPEDIPFVLKSSVNNYYT 402
Query: 363 VRNQTVLDREAHSSLRMKV 381
+ + LDRE+ + + +
Sbjct: 403 LETERPLDRESRAEYNITI 421
Score = 56.4 bits (130), Expect = 7e-07
Identities = 59/202 (29%), Positives = 88/202 (43%), Gaps = 23/202 (11%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEF--NSEVYIPPSKLSADALEVKRYFVI 994
LF+ N P I ++A D DSG N Q+ Y + + ++P + L + I
Sbjct: 458 LFVRENNSP-ALHIGSISATDRDSGTNAQVNYSLLPSQDPHLPLASLVS----------I 506
Query: 995 NERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWY 1050
N +GH+ RSL E+ F+ + A D G+ L+ VRV V D ND+ P
Sbjct: 507 NADNGHLFALRSLDYEALQGFQFRVGATDHGSPALSSEALVRVLVLDANDNSPFVLYPLQ 566
Query: 1051 NFN------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSV 1104
N + V A ++ KV A D D GQNA L+Y + + F + G +
Sbjct: 567 NGSAPCTELVPWAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRT 626
Query: 1105 NGELDRETEDKYILTVVARDNG 1126
L K+ L V+ +DNG
Sbjct: 627 ARLLSERDAAKHRLVVLVKDNG 648
Score = 51.6 bits (118), Expect = 2e-05
Identities = 45/166 (27%), Positives = 72/166 (43%), Gaps = 9/166 (5%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G + ++ LDRE+ + F + + Q+ + + D ND+ PVF
Sbjct: 82 GDLLLREMLDREELCGSNEPCVLYFQVLMKNPTQFLQIELQVRDINDHSPVFLEKEMLLE 141
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----IGD 851
I ENS +G +++ A D D G NA+ YT+ + N K+ +
Sbjct: 142 IPENSPVGAVFLLES---AKDLDVGINAVKSYTINPNSHFHVKIRVNPDNRKYPELVLDK 198
Query: 852 SLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+LD E++ L A D G S A + +++ D NDN PEF Q
Sbjct: 199 ALDYEERPELSFILTALDGGSPPRSGTALVRVVVVDINDNSPEFEQ 244
Score = 50.4 bits (115), Expect = 5e-05
Identities = 45/180 (25%), Positives = 73/180 (40%), Gaps = 15/180 (8%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
+ G I PLD E + Y + + A G+ G V I + D NDN P ++
Sbjct: 297 KSGDITLTAPLDFEAIESYSIIIQATDGGGLF---GKSTVRIQVMDVNDNAPEITVSSIT 353
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
I EN T + + + D D G N + ++ + + N L
Sbjct: 354 SPIPEN----TPETVVMVFRIRDRDSGDNGKMVCSIPEDIPFVLKSSVNNYYTLETERPL 409
Query: 854 DREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ------IEENSKVRIH 905
DRE + Y +++ D G L +E + +++ D NDN P F Q + EN+ +H
Sbjct: 410 DRESRAEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYALFVRENNSPALH 469
Score = 44.4 bits (100), Expect = 0.003
Identities = 38/134 (28%), Positives = 56/134 (41%), Gaps = 6/134 (4%)
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQP-S 1087
+ + + V+D+NDH PVF + + E V A D D G NA +Y I P S
Sbjct: 117 LQIELQVRDINDHSPVFLEKEMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTINPNS 176
Query: 1088 DTDLPFEISP---LTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDV 1144
+ ++P L ++ LD E + + A D G D+
Sbjct: 177 HFHVKIRVNPDNRKYPELVLDKALDYEERPELSFILTALDGG-SPPRSGTALVRVVVVDI 235
Query: 1145 NDNSPKF-YAFDEL 1157
NDNSP+F AF E+
Sbjct: 236 NDNSPEFEQAFYEV 249
Score = 43.2 bits (97), Expect = 0.007
Identities = 36/123 (29%), Positives = 58/123 (47%), Gaps = 5/123 (4%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
++S ++++ LD+ G L L + LD + E VL Q + NP + Q +E+
Sbjct: 66 VVSNDNKECLQLDTNTGDLLLREMLDRE-ELCGSNEPCVLYFQVL-MKNPTQFLQ--IEL 121
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
++ D+ND+ P F + I EN P G L A D D G N +Y + +P F +
Sbjct: 122 QVRDINDHSPVFLEKEMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTI-NPNSHFHV 180
Query: 355 DPR 357
R
Sbjct: 181 KIR 183
Score = 39.5 bits (88), Expect = 0.091
Identities = 38/126 (30%), Positives = 54/126 (42%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 541 LSSEALVRVLVLDANDNSP-FVLYPLQNGSAPCTELVPWAAEPGYLVTKVVAVDGDSGQN 599
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + + + N T + S +H L V D P +L
Sbjct: 600 AWLSYQLLKATEPGLFGVWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 658
Query: 553 AVVTIE 558
V+ ++
Sbjct: 659 HVLLVD 664
>AF217746-1|AAK51614.1| 795|Homo sapiens protocadherin-beta12
protein.
Length = 795
Score = 106 bits (254), Expect = 7e-22
Identities = 117/468 (25%), Positives = 202/468 (43%), Gaps = 42/468 (8%)
Query: 442 FVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQR 501
F+ +E+ + D ND++PVF+ + + N+ VG V A D D+G N + Y +
Sbjct: 116 FLQIELQVRDINDHSPVFLEKEML-LEIPENSPVGAVFLLESAKDLDVGINAVKSYTINP 174
Query: 502 TSNLTITSPFKINPNTGTVS--VAESPI-LEGRHAL--FVEASDQPANPSERRYSLAVVT 556
S+ + ++NP+ V + + E R L + A D + P + VV
Sbjct: 175 NSHFHVK--IRVNPDNRKYPELVLDKALDYEERPELSFILTALDGGSPPRSGTALVRVVV 232
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGY 614
+++ + P+F A YE + N +G+ V + D+ +++SY H
Sbjct: 233 VDINDNS-------PEFEQAFYEVKILENSILGSLVVTVSAWDLDSGTNSELSYTFSHAS 285
Query: 615 EE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDER 673
E+ F + ++SG IT+ L Y + + L + + V+DVND
Sbjct: 286 EDIRKTFEINQKSGDITLTAPLDFEAIESYSI-IIQATDGGGLFGKSTVRIQVMDVNDNA 344
Query: 674 GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIA 733
+ S I + EN+ + +F NG + + + +D+ + +
Sbjct: 345 PEITV---SSITSPIPENTPETVV-MVFRIRDRDSGDNG----KMVCSIPEDIPFVLKSS 396
Query: 734 EDG--TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
+ T+ T++PLDRE R Y +T+ + G + +T+ + D NDN P F +
Sbjct: 397 VNNYYTLETERPLDRESRAEYNITITVT-DLGTPRLKTEHNITVLVSDVNDNAPAFTQTS 455
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDENTGV 845
Y F+ EN+ I I ATD D GTNA Y+L + ++ + G
Sbjct: 456 YALFVRENNSPALHI---GSISATDRDSGTNAQVNYSLLPSQDPHLPLASLVSINADNGH 512
Query: 846 VKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
+ F SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 513 L-FALRSLDYEALQGFQFRVGATDHGSPALSSEALVRVLVLDANDNSP 559
Score = 101 bits (241), Expect = 3e-20
Identities = 130/513 (25%), Positives = 214/513 (41%), Gaps = 76/513 (14%)
Query: 930 DVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLS 982
D++ P+FL IPEN P+G + +A DLD G+N Y N P S
Sbjct: 125 DINDHSPVFLEKEMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTIN-----PNSHFH 179
Query: 983 ADALEVKRYFVINERHGHVIVARSLPPESEFRLN--ISALDGGN--LNDNISVRVFVKDV 1038
R N ++ +++ ++L E L+ ++ALDGG+ + VRV V D+
Sbjct: 180 VKI----RVNPDNRKYPELVLDKALDYEERPELSFILTALDGGSPPRSGTALVRVVVVDI 235
Query: 1039 NDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDL--PFEIS 1096
ND+ P F++ +Y + E ++ V A D D G N+ L+Y + D+ FEI+
Sbjct: 236 NDNSPEFEQAFYEVKILENSILGSLVVTVSAWDLDSGTNSELSYTFSHASEDIRKTFEIN 295
Query: 1097 PLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF--YAF 1154
+G +++ LD E + Y + + A D G DVNDN+P+ +
Sbjct: 296 QKSGDITLTAPLDFEAIESYSIIIQATDGG---GLFGKSTVRIQVMDVNDNAPEITVSSI 352
Query: 1155 DELLEWKHPEA--------DELSNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDT 1204
+ PE D S N + V IP E+ P + ++V + +T
Sbjct: 353 TSPIPENTPETVVMVFRIRDRDSGDNGKMVCSIP-------EDIPFVLKSSVNNYYTLET 405
Query: 1205 DFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYEL 1264
+ + Y++ +LG P L + + V V+DV D + P F Y L
Sbjct: 406 ERPLDRESRAEYNI--TITVTDLGTPRLKTEHNITVLVSDVND-----NAPAFTQTSYAL 458
Query: 1265 EIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRS 1320
+ EN + + + S++ T+ N ++ Y +L D + + I+ NG L+ +RS
Sbjct: 459 FVRENNSPALHIGSISATDRDSGTNAQVNYSLLPSQDPHLPLASLVSINADNGHLFALRS 518
Query: 1321 PDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP-- 1378
D E ++ V A H ++ + L V V + D NDNSP
Sbjct: 519 LDYEALQGFQFRVGA--------TDHGSPALSSEAL---------VRVLVLDANDNSPFV 561
Query: 1379 --KFTNGNRPLVTAIPTTAPFGYQVMQLKGAIG 1409
NG+ P +P A GY V ++ G
Sbjct: 562 LYPLQNGSAPCTELVPWAAEPGYLVTKVVAVDG 594
Score = 75.4 bits (177), Expect = 1e-12
Identities = 78/323 (24%), Positives = 143/323 (44%), Gaps = 30/323 (9%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLIAN 722
+ V D+ND V L+ ++ + ENS +G +F + G V+ + I
Sbjct: 121 LQVRDINDHSPVFLE---KEMLLEIPENSP---VGAVFLLESAKDLDVGINAVKSYTINP 174
Query: 723 QQDVTDDIAIAEDGTIFTQ----KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIE 778
I + D + + K LD E+R ++ + G +G V + +
Sbjct: 175 NSHFHVKIRVNPDNRKYPELVLDKALDYEERPELSF-ILTALDGGSPPRSGTALVRVVVV 233
Query: 779 DENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM-- 836
D NDN P FE A YE I+ENS +G+ + + A D D GTN+ YT +++
Sbjct: 234 DINDNSPEFEQAFYEVKILENSILGSLVV---TVSAWDLDSGTNSELSYTFSHASEDIRK 290
Query: 837 -FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQ 895
F++++ +G + LD E Y + + A D GGL ++ + I + D NDN PE
Sbjct: 291 TFEINQKSGDITLTA-PLDFEAIESYSIIIQATDGGGLFGKSTVRIQVMDVNDNAPEITV 349
Query: 896 IEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIP--IGTTIIKL 953
S + T ++ + +++ + D ++ + IPE+IP + +++
Sbjct: 350 SSITSPIP-------ENTPETVVMVFRIRDRDSGDNGKM--VCSIPEDIPFVLKSSVNNY 400
Query: 954 NALDLDSGLNGQIRYEFNSEVYI 976
L+ + L+ + R E+N + +
Sbjct: 401 YTLETERPLDRESRAEYNITITV 423
Score = 70.1 bits (164), Expect = 6e-11
Identities = 85/324 (26%), Positives = 137/324 (42%), Gaps = 29/324 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTP-TGEKAFIFLIAPIGPS----LTIPLTVPR 136
+V + + DVNDN P + + E TP T F G + +IP +P
Sbjct: 332 TVRIQVMDVNDNAPEITVSSITSPIPENTPETVVMVFRIRDRDSGDNGKMVCSIPEDIPF 391
Query: 137 GL-TIFKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
L + + + ++P S Y+I ++ D G L++ H +L+ V D
Sbjct: 392 VLKSSVNNYYTLETERPLDRESRAEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPAF 451
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLFSLDSV 249
+ + + + L I A D+D G A + Y L+ D L S+++
Sbjct: 452 TQTSYALFV--RENNSPALHIGSISATDRDSGTNAQVNYSLLPSQDPHLPLASLVSINAD 509
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
NG LF + LD +A LQ F +V A+ +P +++A V + +LD NDN P
Sbjct: 510 NGHLFALRSLDYEA---LQG--FQFRVGATDHGSPALSSEALVRVLVLDANDNSPFVLYP 564
Query: 310 FYNISI--VENLP----NGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWL 361
N S E +P G+ V +V+A D D G+N +YQL G F + +G
Sbjct: 565 LQNGSAPCTELVPWAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG-- 622
Query: 362 TVRNQTVLDREAHSSLRMKVYAKE 385
VR +L + R+ V K+
Sbjct: 623 EVRTARLLSERDAAKHRLVVLVKD 646
Score = 65.7 bits (153), Expect = 1e-09
Identities = 47/137 (34%), Positives = 71/137 (51%), Gaps = 11/137 (8%)
Query: 253 LFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN 312
L L+K LD + L +F+L A +P ++ A V + ++D+NDN PEFE FY
Sbjct: 194 LVLDKALDYEERPEL---SFILT--ALDGGSPPRSGTALVRVVVVDINDNSPEFEQAFYE 248
Query: 313 ISIVENLPNGFSVLQVMATDKDQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTV 368
+ I+EN G V+ V A D D G N E +Y +D + F I+ +SG +T+
Sbjct: 249 VKILENSILGSLVVTVSAWDLDSGTNSELSYTFSHASEDIRKTFEINQKSGDITL--TAP 306
Query: 369 LDREAHSSLRMKVYAKE 385
LD EA S + + A +
Sbjct: 307 LDFEAIESYSIIIQATD 323
Score = 62.9 bits (146), Expect = 9e-09
Identities = 69/319 (21%), Positives = 130/319 (40%), Gaps = 30/319 (9%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLT 139
+L + + + D+ND+ P+FL+ + + E +P G +FL+ L + + + T
Sbjct: 116 FLQIELQVRDINDHSPVFLEKEMLLEIPENSPVGA---VFLLES-AKDLDVGINAVKSYT 171
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGH---------FALESSHKP----VLLLRK 186
I + + + N N ++ D AL+ P L+
Sbjct: 172 INPNSHFHVKIRVNPDNRKYPELVLDKALDYEERPELSFILTALDGGSPPRSGTALVRVV 231
Query: 187 VLDYDAGDKEFQLVIMASGKRIHKEIL--FPEPIHAIDQDLGVGATLRYELISGND--RK 242
V+D + EF+ K + IL + A D D G + L Y ++ RK
Sbjct: 232 VVDINDNSPEFEQAFYEV-KILENSILGSLVVTVSAWDLDSGTNSELSYTFSHASEDIRK 290
Query: 243 LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDN 302
F ++ +G + L LD +A ++ + +QA+ ++ V I+++D+NDN
Sbjct: 291 TFEINQKSGDITLTAPLDFEA-----IESYSIIIQATDGGGLF--GKSTVRIQVMDVNDN 343
Query: 303 LPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLT 362
PE V I EN P V+ D+D G+NG+ + + + + T
Sbjct: 344 APEITVSSITSPIPENTPETV-VMVFRIRDRDSGDNGKMVCSIPEDIPFVLKSSVNNYYT 402
Query: 363 VRNQTVLDREAHSSLRMKV 381
+ + LDRE+ + + +
Sbjct: 403 LETERPLDRESRAEYNITI 421
Score = 56.4 bits (130), Expect = 7e-07
Identities = 59/202 (29%), Positives = 88/202 (43%), Gaps = 23/202 (11%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEF--NSEVYIPPSKLSADALEVKRYFVI 994
LF+ N P I ++A D DSG N Q+ Y + + ++P + L + I
Sbjct: 458 LFVRENNSP-ALHIGSISATDRDSGTNAQVNYSLLPSQDPHLPLASLVS----------I 506
Query: 995 NERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWY 1050
N +GH+ RSL E+ F+ + A D G+ L+ VRV V D ND+ P
Sbjct: 507 NADNGHLFALRSLDYEALQGFQFRVGATDHGSPALSSEALVRVLVLDANDNSPFVLYPLQ 566
Query: 1051 NFN------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSV 1104
N + V A ++ KV A D D GQNA L+Y + + F + G +
Sbjct: 567 NGSAPCTELVPWAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRT 626
Query: 1105 NGELDRETEDKYILTVVARDNG 1126
L K+ L V+ +DNG
Sbjct: 627 ARLLSERDAAKHRLVVLVKDNG 648
Score = 51.6 bits (118), Expect = 2e-05
Identities = 45/166 (27%), Positives = 72/166 (43%), Gaps = 9/166 (5%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G + ++ LDRE+ + F + + Q+ + + D ND+ PVF
Sbjct: 82 GDLLLREMLDREELCGSNEPCVLYFQVLMKNPTQFLQIELQVRDINDHSPVFLEKEMLLE 141
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----IGD 851
I ENS +G +++ A D D G NA+ YT+ + N K+ +
Sbjct: 142 IPENSPVGAVFLLES---AKDLDVGINAVKSYTINPNSHFHVKIRVNPDNRKYPELVLDK 198
Query: 852 SLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+LD E++ L A D G S A + +++ D NDN PEF Q
Sbjct: 199 ALDYEERPELSFILTALDGGSPPRSGTALVRVVVVDINDNSPEFEQ 244
Score = 50.4 bits (115), Expect = 5e-05
Identities = 45/180 (25%), Positives = 73/180 (40%), Gaps = 15/180 (8%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
+ G I PLD E + Y + + A G+ G V I + D NDN P ++
Sbjct: 297 KSGDITLTAPLDFEAIESYSIIIQATDGGGLF---GKSTVRIQVMDVNDNAPEITVSSIT 353
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
I EN T + + + D D G N + ++ + + N L
Sbjct: 354 SPIPEN----TPETVVMVFRIRDRDSGDNGKMVCSIPEDIPFVLKSSVNNYYTLETERPL 409
Query: 854 DREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ------IEENSKVRIH 905
DRE + Y +++ D G L +E + +++ D NDN P F Q + EN+ +H
Sbjct: 410 DRESRAEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYALFVRENNSPALH 469
Score = 44.4 bits (100), Expect = 0.003
Identities = 38/134 (28%), Positives = 56/134 (41%), Gaps = 6/134 (4%)
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQP-S 1087
+ + + V+D+NDH PVF + + E V A D D G NA +Y I P S
Sbjct: 117 LQIELQVRDINDHSPVFLEKEMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTINPNS 176
Query: 1088 DTDLPFEISP---LTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDV 1144
+ ++P L ++ LD E + + A D G D+
Sbjct: 177 HFHVKIRVNPDNRKYPELVLDKALDYEERPELSFILTALDGG-SPPRSGTALVRVVVVDI 235
Query: 1145 NDNSPKF-YAFDEL 1157
NDNSP+F AF E+
Sbjct: 236 NDNSPEFEQAFYEV 249
Score = 43.2 bits (97), Expect = 0.007
Identities = 36/123 (29%), Positives = 58/123 (47%), Gaps = 5/123 (4%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
++S ++++ LD+ G L L + LD + E VL Q + NP + Q +E+
Sbjct: 66 VVSNDNKECLQLDTNTGDLLLREMLDRE-ELCGSNEPCVLYFQVL-MKNPTQFLQ--IEL 121
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
++ D+ND+ P F + I EN P G L A D D G N +Y + +P F +
Sbjct: 122 QVRDINDHSPVFLEKEMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTI-NPNSHFHV 180
Query: 355 DPR 357
R
Sbjct: 181 KIR 183
Score = 39.5 bits (88), Expect = 0.091
Identities = 38/126 (30%), Positives = 54/126 (42%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 541 LSSEALVRVLVLDANDNSP-FVLYPLQNGSAPCTELVPWAAEPGYLVTKVVAVDGDSGQN 599
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + + + N T + S +H L V D P +L
Sbjct: 600 AWLSYQLLKATEPGLFGVWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 658
Query: 553 AVVTIE 558
V+ ++
Sbjct: 659 HVLLVD 664
>AF152491-1|AAD43752.1| 795|Homo sapiens protocadherin beta 12
protein.
Length = 795
Score = 106 bits (254), Expect = 7e-22
Identities = 117/468 (25%), Positives = 202/468 (43%), Gaps = 42/468 (8%)
Query: 442 FVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQR 501
F+ +E+ + D ND++PVF+ + + N+ VG V A D D+G N + Y +
Sbjct: 116 FLQIELQVRDINDHSPVFLEKEML-LEIPENSPVGAVFLLESAKDLDVGINAVKSYTINP 174
Query: 502 TSNLTITSPFKINPNTGTVS--VAESPI-LEGRHAL--FVEASDQPANPSERRYSLAVVT 556
S+ + ++NP+ V + + E R L + A D + P + VV
Sbjct: 175 NSHFHVK--IRVNPDNRKYPELVLDKALDYEERPELSFILTALDGGSPPRSGTALVRVVV 232
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGY 614
+++ + P+F A YE + N +G+ V + D+ +++SY H
Sbjct: 233 VDINDNS-------PEFEQAFYEVKILENSILGSLVVTVSAWDLDSGTNSELSYTFSHAS 285
Query: 615 EE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDER 673
E+ F + ++SG IT+ L Y + + L + + V+DVND
Sbjct: 286 EDIRKTFEINQKSGDITLTAPLDFEAIESYSI-IIQATDGGGLFGKSTVRIQVMDVNDNA 344
Query: 674 GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIA 733
+ S I + EN+ + +F NG + + + +D+ + +
Sbjct: 345 PEITV---SSITSPIPENTPETVV-MVFRIRDRDSGDNG----KMVCSIPEDIPFVLKSS 396
Query: 734 EDG--TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
+ T+ T++PLDRE R Y +T+ + G + +T+ + D NDN P F +
Sbjct: 397 VNNYYTLETERPLDRESRAEYNITITVT-DLGTPRLKTEHNITVLVSDVNDNAPAFTQTS 455
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDENTGV 845
Y F+ EN+ I I ATD D GTNA Y+L + ++ + G
Sbjct: 456 YALFVRENNSPALHI---GSISATDRDSGTNAQVNYSLLPSQDPHLPLASLVSINADNGH 512
Query: 846 VKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
+ F SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 513 L-FALRSLDYEALQGFQFRVGATDHGSPALSSEALVRVLVLDANDNSP 559
Score = 101 bits (241), Expect = 3e-20
Identities = 130/513 (25%), Positives = 214/513 (41%), Gaps = 76/513 (14%)
Query: 930 DVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLS 982
D++ P+FL IPEN P+G + +A DLD G+N Y N P S
Sbjct: 125 DINDHSPVFLEKEMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTIN-----PNSHFH 179
Query: 983 ADALEVKRYFVINERHGHVIVARSLPPESEFRLN--ISALDGGN--LNDNISVRVFVKDV 1038
R N ++ +++ ++L E L+ ++ALDGG+ + VRV V D+
Sbjct: 180 VKI----RVNPDNRKYPELVLDKALDYEERPELSFILTALDGGSPPRSGTALVRVVVVDI 235
Query: 1039 NDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDL--PFEIS 1096
ND+ P F++ +Y + E ++ V A D D G N+ L+Y + D+ FEI+
Sbjct: 236 NDNSPEFEQAFYEVKILENSILGSLVVTVSAWDLDSGTNSELSYTFSHASEDIRKTFEIN 295
Query: 1097 PLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF--YAF 1154
+G +++ LD E + Y + + A D G DVNDN+P+ +
Sbjct: 296 QKSGDITLTAPLDFEAIESYSIIIQATDGG---GLFGKSTVRIQVMDVNDNAPEITVSSI 352
Query: 1155 DELLEWKHPEA--------DELSNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDT 1204
+ PE D S N + V IP E+ P + ++V + +T
Sbjct: 353 TSPIPENTPETVVMVFRIRDRDSGDNGKMVCSIP-------EDIPFVLKSSVNNYYTLET 405
Query: 1205 DFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYEL 1264
+ + Y++ +LG P L + + V V+DV D + P F Y L
Sbjct: 406 ERPLDRESRAEYNI--TITVTDLGTPRLKTEHNITVLVSDVND-----NAPAFTQTSYAL 458
Query: 1265 EIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRS 1320
+ EN + + + S++ T+ N ++ Y +L D + + I+ NG L+ +RS
Sbjct: 459 FVRENNSPALHIGSISATDRDSGTNAQVNYSLLPSQDPHLPLASLVSINADNGHLFALRS 518
Query: 1321 PDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP-- 1378
D E ++ V A H ++ + L V V + D NDNSP
Sbjct: 519 LDYEALQGFQFRVGA--------TDHGSPALSSEAL---------VRVLVLDANDNSPFV 561
Query: 1379 --KFTNGNRPLVTAIPTTAPFGYQVMQLKGAIG 1409
NG+ P +P A GY V ++ G
Sbjct: 562 LYPLQNGSAPCTELVPWAAEPGYLVTKVVAVDG 594
Score = 75.4 bits (177), Expect = 1e-12
Identities = 78/323 (24%), Positives = 143/323 (44%), Gaps = 30/323 (9%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLIAN 722
+ V D+ND V L+ ++ + ENS +G +F + G V+ + I
Sbjct: 121 LQVRDINDHSPVFLE---KEMLLEIPENSP---VGAVFLLESAKDLDVGINAVKSYTINP 174
Query: 723 QQDVTDDIAIAEDGTIFTQ----KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIE 778
I + D + + K LD E+R ++ + G +G V + +
Sbjct: 175 NSHFHVKIRVNPDNRKYPELVLDKALDYEERPELSF-ILTALDGGSPPRSGTALVRVVVV 233
Query: 779 DENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM-- 836
D NDN P FE A YE I+ENS +G+ + + A D D GTN+ YT +++
Sbjct: 234 DINDNSPEFEQAFYEVKILENSILGSLVV---TVSAWDLDSGTNSELSYTFSHASEDIRK 290
Query: 837 -FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQ 895
F++++ +G + LD E Y + + A D GGL ++ + I + D NDN PE
Sbjct: 291 TFEINQKSGDITLTA-PLDFEAIESYSIIIQATDGGGLFGKSTVRIQVMDVNDNAPEITV 349
Query: 896 IEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIP--IGTTIIKL 953
S + T ++ + +++ + D ++ + IPE+IP + +++
Sbjct: 350 SSITSPIP-------ENTPETVVMVFRIRDRDSGDNGKM--VCSIPEDIPFVLKSSVNNY 400
Query: 954 NALDLDSGLNGQIRYEFNSEVYI 976
L+ + L+ + R E+N + +
Sbjct: 401 YTLETERPLDRESRAEYNITITV 423
Score = 70.1 bits (164), Expect = 6e-11
Identities = 85/324 (26%), Positives = 137/324 (42%), Gaps = 29/324 (8%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTP-TGEKAFIFLIAPIGPS----LTIPLTVPR 136
+V + + DVNDN P + + E TP T F G + +IP +P
Sbjct: 332 TVRIQVMDVNDNAPEITVSSITSPIPENTPETVVMVFRIRDRDSGDNGKMVCSIPEDIPF 391
Query: 137 GL-TIFKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
L + + + ++P S Y+I ++ D G L++ H +L+ V D
Sbjct: 392 VLKSSVNNYYTLETERPLDRESRAEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPAF 451
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLFSLDSV 249
+ + + + L I A D+D G A + Y L+ D L S+++
Sbjct: 452 TQTSYALFV--RENNSPALHIGSISATDRDSGTNAQVNYSLLPSQDPHLPLASLVSINAD 509
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
NG LF + LD +A LQ F +V A+ +P +++A V + +LD NDN P
Sbjct: 510 NGHLFALRSLDYEA---LQG--FQFRVGATDHGSPALSSEALVRVLVLDANDNSPFVLYP 564
Query: 310 FYNISI--VENLP----NGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWL 361
N S E +P G+ V +V+A D D G+N +YQL G F + +G
Sbjct: 565 LQNGSAPCTELVPWAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG-- 622
Query: 362 TVRNQTVLDREAHSSLRMKVYAKE 385
VR +L + R+ V K+
Sbjct: 623 EVRTARLLSERDAAKHRLVVLVKD 646
Score = 65.7 bits (153), Expect = 1e-09
Identities = 47/137 (34%), Positives = 71/137 (51%), Gaps = 11/137 (8%)
Query: 253 LFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYN 312
L L+K LD + L +F+L A +P ++ A V + ++D+NDN PEFE FY
Sbjct: 194 LVLDKALDYEERPEL---SFILT--ALDGGSPPRSGTALVRVVVVDINDNSPEFEQAFYE 248
Query: 313 ISIVENLPNGFSVLQVMATDKDQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTV 368
+ I+EN G V+ V A D D G N E +Y +D + F I+ +SG +T+
Sbjct: 249 VKILENSILGSLVVTVSAWDLDSGTNSELSYTFSHASEDIRKTFEINQKSGDITL--TAP 306
Query: 369 LDREAHSSLRMKVYAKE 385
LD EA S + + A +
Sbjct: 307 LDFEAIESYSIIIQATD 323
Score = 62.9 bits (146), Expect = 9e-09
Identities = 69/319 (21%), Positives = 130/319 (40%), Gaps = 30/319 (9%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLT 139
+L + + + D+ND+ P+FL+ + + E +P G +FL+ L + + + T
Sbjct: 116 FLQIELQVRDINDHSPVFLEKEMLLEIPENSPVGA---VFLLES-AKDLDVGINAVKSYT 171
Query: 140 IFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGH---------FALESSHKP----VLLLRK 186
I + + + N N ++ D AL+ P L+
Sbjct: 172 INPNSHFHVKIRVNPDNRKYPELVLDKALDYEERPELSFILTALDGGSPPRSGTALVRVV 231
Query: 187 VLDYDAGDKEFQLVIMASGKRIHKEIL--FPEPIHAIDQDLGVGATLRYELISGND--RK 242
V+D + EF+ K + IL + A D D G + L Y ++ RK
Sbjct: 232 VVDINDNSPEFEQAFYEV-KILENSILGSLVVTVSAWDLDSGTNSELSYTFSHASEDIRK 290
Query: 243 LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDN 302
F ++ +G + L LD +A ++ + +QA+ ++ V I+++D+NDN
Sbjct: 291 TFEINQKSGDITLTAPLDFEA-----IESYSIIIQATDGGGLF--GKSTVRIQVMDVNDN 343
Query: 303 LPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLT 362
PE V I EN P V+ D+D G+NG+ + + + + T
Sbjct: 344 APEITVSSITSPIPENTPETV-VMVFRIRDRDSGDNGKMVCSIPEDIPFVLKSSVNNYYT 402
Query: 363 VRNQTVLDREAHSSLRMKV 381
+ + LDRE+ + + +
Sbjct: 403 LETERPLDRESRAEYNITI 421
Score = 56.4 bits (130), Expect = 7e-07
Identities = 59/202 (29%), Positives = 88/202 (43%), Gaps = 23/202 (11%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEF--NSEVYIPPSKLSADALEVKRYFVI 994
LF+ N P I ++A D DSG N Q+ Y + + ++P + L + I
Sbjct: 458 LFVRENNSP-ALHIGSISATDRDSGTNAQVNYSLLPSQDPHLPLASLVS----------I 506
Query: 995 NERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWY 1050
N +GH+ RSL E+ F+ + A D G+ L+ VRV V D ND+ P
Sbjct: 507 NADNGHLFALRSLDYEALQGFQFRVGATDHGSPALSSEALVRVLVLDANDNSPFVLYPLQ 566
Query: 1051 NFN------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSV 1104
N + V A ++ KV A D D GQNA L+Y + + F + G +
Sbjct: 567 NGSAPCTELVPWAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRT 626
Query: 1105 NGELDRETEDKYILTVVARDNG 1126
L K+ L V+ +DNG
Sbjct: 627 ARLLSERDAAKHRLVVLVKDNG 648
Score = 51.6 bits (118), Expect = 2e-05
Identities = 45/166 (27%), Positives = 72/166 (43%), Gaps = 9/166 (5%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G + ++ LDRE+ + F + + Q+ + + D ND+ PVF
Sbjct: 82 GDLLLREMLDREELCGSNEPCVLYFQVLMKNPTQFLQIELQVRDINDHSPVFLEKEMLLE 141
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----IGD 851
I ENS +G +++ A D D G NA+ YT+ + N K+ +
Sbjct: 142 IPENSPVGAVFLLES---AKDLDVGINAVKSYTINPNSHFHVKIRVNPDNRKYPELVLDK 198
Query: 852 SLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+LD E++ L A D G S A + +++ D NDN PEF Q
Sbjct: 199 ALDYEERPELSFILTALDGGSPPRSGTALVRVVVVDINDNSPEFEQ 244
Score = 50.4 bits (115), Expect = 5e-05
Identities = 45/180 (25%), Positives = 73/180 (40%), Gaps = 15/180 (8%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
+ G I PLD E + Y + + A G+ G V I + D NDN P ++
Sbjct: 297 KSGDITLTAPLDFEAIESYSIIIQATDGGGLF---GKSTVRIQVMDVNDNAPEITVSSIT 353
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
I EN T + + + D D G N + ++ + + N L
Sbjct: 354 SPIPEN----TPETVVMVFRIRDRDSGDNGKMVCSIPEDIPFVLKSSVNNYYTLETERPL 409
Query: 854 DREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ------IEENSKVRIH 905
DRE + Y +++ D G L +E + +++ D NDN P F Q + EN+ +H
Sbjct: 410 DRESRAEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYALFVRENNSPALH 469
Score = 44.4 bits (100), Expect = 0.003
Identities = 38/134 (28%), Positives = 56/134 (41%), Gaps = 6/134 (4%)
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQP-S 1087
+ + + V+D+NDH PVF + + E V A D D G NA +Y I P S
Sbjct: 117 LQIELQVRDINDHSPVFLEKEMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTINPNS 176
Query: 1088 DTDLPFEISP---LTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDV 1144
+ ++P L ++ LD E + + A D G D+
Sbjct: 177 HFHVKIRVNPDNRKYPELVLDKALDYEERPELSFILTALDGG-SPPRSGTALVRVVVVDI 235
Query: 1145 NDNSPKF-YAFDEL 1157
NDNSP+F AF E+
Sbjct: 236 NDNSPEFEQAFYEV 249
Score = 43.2 bits (97), Expect = 0.007
Identities = 36/123 (29%), Positives = 58/123 (47%), Gaps = 5/123 (4%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
++S ++++ LD+ G L L + LD + E VL Q + NP + Q +E+
Sbjct: 66 VVSNDNKECLQLDTNTGDLLLREMLDRE-ELCGSNEPCVLYFQVL-MKNPTQFLQ--IEL 121
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
++ D+ND+ P F + I EN P G L A D D G N +Y + +P F +
Sbjct: 122 QVRDINDHSPVFLEKEMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTI-NPNSHFHV 180
Query: 355 DPR 357
R
Sbjct: 181 KIR 183
Score = 39.5 bits (88), Expect = 0.091
Identities = 38/126 (30%), Positives = 54/126 (42%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 541 LSSEALVRVLVLDANDNSP-FVLYPLQNGSAPCTELVPWAAEPGYLVTKVVAVDGDSGQN 599
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + + + N T + S +H L V D P +L
Sbjct: 600 AWLSYQLLKATEPGLFGVWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 658
Query: 553 AVVTIE 558
V+ ++
Sbjct: 659 HVLLVD 664
>AB046782-1|BAB13388.1| 1136|Homo sapiens KIAA1562 protein protein.
Length = 1136
Score = 106 bits (254), Expect = 7e-22
Identities = 123/473 (26%), Positives = 189/473 (39%), Gaps = 32/473 (6%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E L F ++EV +LD NDN+P F S L + +A VGT I A DPD+G+N +
Sbjct: 117 EHLQLF-HIEVEVLDINDNSPQFSRS-LIPIEISESAAVGTRIPLDSAFDPDVGENSLHT 174
Query: 497 YDLQRTS--NLTITSPFKINPNTGTVSVAE-SPILEGRHALFVEASDQPANPSERRYSLA 553
Y L N+ + + + V E L+ + L + ASD +R +
Sbjct: 175 YSLSANDFFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGV---PQRSGSS 231
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLL 611
++ I ++ + P F Y + N +GT + + D E + Y
Sbjct: 232 ILKISISDSNDNS----PAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFS 287
Query: 612 HGYEEGV--PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVD 668
+ F ++ G +T+ + Y+ + A N + + VVD
Sbjct: 288 SHVSPKIMETFKIDSERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVD 347
Query: 669 VNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNG-TGNVRFLIANQQDVT 727
VND + + SP + G I +G G + +
Sbjct: 348 VNDNKPEININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFK 407
Query: 728 DDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVF 787
+ I T LDREKR Y +TVIAE ++G S + + T+ I D NDNPP F
Sbjct: 408 LQKTYENNYLILTNATLDREKRSEYSLTVIAE-DRGTPSLSTVKHFTVQINDINDNPPHF 466
Query: 788 EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL---FGEGKEM---FDVDE 841
+ + YE I EN+ G I + ATD D G N YT+ F G + +D
Sbjct: 467 QRSRYEFVISENNSPGAYI---TTVTATDPDLGENGQVTYTILESFILGSSITTYVTIDP 523
Query: 842 NTGVVKFIGDSLDREKKIMYKLSLVARDTGG---LSSEAELIIMIGDENDNKP 891
+ G + + D E+ + ARD G L S +++ I DENDN P
Sbjct: 524 SNGAIYALR-IFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVP 575
Score = 92.7 bits (220), Expect = 9e-18
Identities = 109/454 (24%), Positives = 192/454 (42%), Gaps = 30/454 (6%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
+++++ D+NDN+P F + Y + N+ VGT++ + A DPD G NG ++Y +
Sbjct: 233 LKISISDSNDNSPAFEQQS-YIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVS 291
Query: 505 LTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
I FKI+ G +++ + E + + V+A D N + + ++V
Sbjct: 292 PKIMETFKIDSERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDV--- 348
Query: 563 TKGNKPDIPDFMGAPYE---FWVGSNVGIGTSVGQIRVNDAFE-QNDVSYDLLHGYEEGV 618
NKP+I + +P + ++ I T V +RV D N LHG+
Sbjct: 349 -NDNKPEININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFK 407
Query: 619 PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVNDERGVLL 677
E + +I L R R Y +A +LS V + TV + D+ND
Sbjct: 408 LQKTYENNYLILTNATLDREKRSEYSLTVIAEDRGTPSLSTVKHFTVQINDINDNPPHFQ 467
Query: 678 KGAHSPIIFHVKENSAGAAIGQIFHTNMS-SIYGNGTGNVRFLIANQQDVTDDIAI-AED 735
+ + +I + NS GA I + T+ G T + +T + I +
Sbjct: 468 RSRYEFVI--SENNSPGAYITTVTATDPDLGENGQVTYTILESFILGSSITTYVTIDPSN 525
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIY--IEDENDNPPV-----FE 788
G I+ + D E +V ++T + E G + T+ I DENDN PV
Sbjct: 526 GAIYALRIFDHE--EVSQITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVPVVIGPALR 583
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNA-LFMYTLFGEGKEMFDVDENTGVVK 847
+ T E I + ++ G + I+A D D G NA L + G + +F +D + +
Sbjct: 584 NNTAEITIPKGAESGFHVTR---IRAIDRDSGVNAELSCAIVAGNEENIFIIDPRSCDI- 639
Query: 848 FIGDSLDREKKIMYKLSLVARDTGGLSSEAELII 881
S+D ++LS++ +D G ++++
Sbjct: 640 HTNVSMDSVPYTEWELSVIIQDKGNPQLHTKVLL 673
Score = 80.2 bits (189), Expect = 5e-14
Identities = 54/168 (32%), Positives = 84/168 (50%), Gaps = 11/168 (6%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
A+ + + LDRE + Y + + A + GV +G + I I D NDN P FE +Y
Sbjct: 194 AKYAELIVVRELDRELKSSYELQLTAS-DMGVPQRSGSSILKISISDSNDNSPAFEQQSY 252
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGK----EMFDVDENTGVVKF 848
++ENS +GT + +D + ATD DEG N +Y+ E F +D G +
Sbjct: 253 IIQLLENSPVGT-LLLD--LNATDPDEGANGKIVYSFSSHVSPKIMETFKIDSERGHLTL 309
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFN 894
+D E Y++ + A+D G + + ++II + D NDNKPE N
Sbjct: 310 F-KQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEIN 356
Score = 77.8 bits (183), Expect = 3e-13
Identities = 52/177 (29%), Positives = 88/177 (49%), Gaps = 8/177 (4%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D+G + Y L + + + +G+ + E + + + L+++ + LQ+ AS
Sbjct: 162 AFDPDVGENSLHTYSLSANDFFNIEVRTRTDGAKYAELIVVRELDRELKSS-YELQLTAS 220
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
+ P ++ + ++I + D NDN P FE Y I ++EN P G +L + ATD D+G NG
Sbjct: 221 DMGVPQRSGSSILKISISDSNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANG 280
Query: 340 EFTYQLD---DPK--GAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVV 391
+ Y PK F ID G LT+ Q +D E S + V A++ P+ +
Sbjct: 281 KIVYSFSSHVSPKIMETFKIDSERGHLTLFKQ--VDYEITKSYEIDVQAQDLGPNSI 335
Score = 70.1 bits (164), Expect = 6e-11
Identities = 61/243 (25%), Positives = 99/243 (40%), Gaps = 21/243 (8%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
I + N + +Q + + EN P+GT ++ LNA D D G NG+I Y F+S V
Sbjct: 235 ISISDSNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHV---- 290
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG--NLNDNISVRVF 1034
+ ++ F I+ GH+ + + + E + +++ A D G ++ + + +
Sbjct: 291 ------SPKIMETFKIDSERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIK 344
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQY------TRRVLGKVDATDADFGQNANLTYFIQPSD 1088
V DVND+ P + EE Y + V D D G N + +
Sbjct: 345 VVDVNDNKPEININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHG 404
Query: 1089 TDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
+ ++ N LDRE +Y LTV+A D G D+NDN
Sbjct: 405 HFKLQKTYENNYLILTNATLDREKRSEYSLTVIAEDRG-TPSLSTVKHFTVQINDINDNP 463
Query: 1149 PKF 1151
P F
Sbjct: 464 PHF 466
Score = 68.9 bits (161), Expect = 1e-10
Identities = 109/442 (24%), Positives = 182/442 (41%), Gaps = 57/442 (12%)
Query: 929 LDVDQLGPLF---LIP----ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD++ P F LIP E+ +GT I +A D D G N Y ++ +
Sbjct: 129 LDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSANDFFN---- 184
Query: 982 SADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG--NLNDNISVRVFVKD 1037
+EV R ++ +IV R L E S + L ++A D G + + +++ + D
Sbjct: 185 ----IEV-RTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGVPQRSGSSILKISISD 239
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY----FIQPSDTDLPF 1093
ND+ P F++ Y + E +L ++ATD D G N + Y + P + F
Sbjct: 240 SNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIME-TF 298
Query: 1094 EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYA 1153
+I G L++ ++D E Y + V A+D G DVNDN P+
Sbjct: 299 KIDSERGHLTLFKQVDYEITKSYEIDVQAQDLG-PNSIPAHCKIIIKVVDVNDNKPEIN- 356
Query: 1154 FDELLEWKHPEADELSNHNFES---VMMIPVYKATIEENAPIGTTVAKVFAN---DTDFI 1207
+ P +E+S + FE + + + +++ G V K+ +
Sbjct: 357 ----INLMSPGKEEIS-YIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKT 411
Query: 1208 GNGNGLILYSLP---QRKNQQNL-------GLPSLSSTAILMVTVADVPDEVEMSDKPVF 1257
N LIL + +++++ +L G PSLS+ V + D+ D + P F
Sbjct: 412 YENNYLILTNATLDREKRSEYSLTVIAEDRGTPSLSTVKHFTVQINDIND-----NPPHF 466
Query: 1258 ISRYYELEIEENVNAPVELVSLNLTEH--YENFKMRYYILNE--NDTDIRRTFVIDPRNG 1313
YE I EN + + ++ T+ EN ++ Y IL + I IDP NG
Sbjct: 467 QRSRYEFVISENNSPGAYITTVTATDPDLGENGQVTYTILESFILGSSITTYVTIDPSNG 526
Query: 1314 TLYLVRSPDREVKDTYEVIVRA 1335
+Y +R D E +V A
Sbjct: 527 AIYALRIFDHEEVSQITFVVEA 548
Score = 67.7 bits (158), Expect = 3e-10
Identities = 59/189 (31%), Positives = 86/189 (45%), Gaps = 13/189 (6%)
Query: 716 VRFLIANQQDVTDDIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKGVI--SGAGIYQ 772
VRF A Q+ + + + ED G I +DRE+ + EF+ + ++
Sbjct: 65 VRFR-AMQRGNSPLLVVNEDNGEISIGATIDREQLCQKNLNCSIEFDVITLPTEHLQLFH 123
Query: 773 VTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGE 832
+ + + D NDN P F + I E++ +GT I +D+ A D D G N+L Y+L
Sbjct: 124 IEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDS---AFDPDVGENSLHTYSLSAN 180
Query: 833 GKEMFDVDENTGVVKF----IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDE 886
+V T K+ + LDRE K Y+L L A D G S + L I I D
Sbjct: 181 DFFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGVPQRSGSSILKISISDS 240
Query: 887 NDNKPEFNQ 895
NDN P F Q
Sbjct: 241 NDNSPAFEQ 249
Score = 66.1 bits (154), Expect = 9e-10
Identities = 61/236 (25%), Positives = 92/236 (38%), Gaps = 22/236 (9%)
Query: 925 NKFALDVDQLGP----LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSK 980
NK ++++ + P + I E PI T + + D DSGLNG+I + + + K
Sbjct: 351 NKPEININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQK 410
Query: 981 LSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGG--NLNDNISVRVFVKDV 1038
+ Y ++ SE+ L + A D G +L+ V + D+
Sbjct: 411 TYEN-----NYLILTN------ATLDREKRSEYSLTVIAEDRGTPSLSTVKHFTVQINDI 459
Query: 1039 NDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-----FIQPSDTDLPF 1093
ND+ P F+++ Y F + E + V ATD D G+N +TY FI S
Sbjct: 460 NDNPPHFQRSRYEFVISENNSPGAYITTVTATDPDLGENGQVTYTILESFILGSSITTYV 519
Query: 1094 EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
I P G + D E + V ARD G D NDN P
Sbjct: 520 TIDPSNGAIYALRIFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVP 575
Score = 59.3 bits (137), Expect = 1e-07
Identities = 74/299 (24%), Positives = 118/299 (39%), Gaps = 42/299 (14%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGE----------------KA 116
G+ Q S + + I D NDN P F Y + + E +P G K
Sbjct: 223 GVPQRSGSSILKISISDSNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKI 282
Query: 117 FIFLIAPIGPSL--TIPLTVPRG-LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFA 173
+ + P + T + RG LT+FK + D T + ++ V D G +
Sbjct: 283 VYSFSSHVSPKIMETFKIDSERGHLTLFKQV-----DYEITKSYEID---VQAQDLGPNS 334
Query: 174 LESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI-------DQDLG 226
+ + K ++ KV+D + E + +M+ GK I +PI D+D G
Sbjct: 335 IPAHCKIII---KVVDVNDNKPEININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSG 391
Query: 227 VGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLK 286
+ + +L KL N + LD + + + + L V A P
Sbjct: 392 LNGEIVCKLHGHGHFKLQKTYENNYLILTNATLDRE-----KRSEYSLTVIAEDRGTPSL 446
Query: 287 TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+ +++ D+NDN P F+ Y I EN G + V ATD D GENG+ TY +
Sbjct: 447 STVKHFTVQINDINDNPPHFQRSRYEFVISENNSPGAYITTVTATDPDLGENGQVTYTI 505
Score = 58.8 bits (136), Expect = 1e-07
Identities = 123/575 (21%), Positives = 219/575 (38%), Gaps = 66/575 (11%)
Query: 571 PDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVP--FAVEERSGV 628
P F + + + +GT +I ++ AF+ DV + LH Y F +E R+
Sbjct: 136 PQFSRSLIPIEISESAAVGT---RIPLDSAFDP-DVGENSLHTYSLSANDFFNIEVRTRT 191
Query: 629 -------ITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAH 681
+ VV +L R + Y+ + A + + + +++ + ++D
Sbjct: 192 DGAKYAELIVVRELDRELKSSYELQLTA--SDMGVPQRSGSSILKISISDSNDNSPAFEQ 249
Query: 682 SPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFT 740
I + ENS + + NG F + + I +E G +
Sbjct: 250 QSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIMETFKIDSERGHLTL 309
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP-----VFEHATYE-G 794
K +D E Y + V A+ + G S ++ I + D NDN P + E
Sbjct: 310 FKQVDYEITKSYEIDVQAQ-DLGPNSIPAHCKIIIKVVDVNDNKPEININLMSPGKEEIS 368
Query: 795 FIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLD 854
+I E I T + + ++ D D G N + L G G + +LD
Sbjct: 369 YIFEGDPIDTFVAL---VRVQDKDSGLNGEIVCKLHGHGHFKLQKTYENNYLILTNATLD 425
Query: 855 REKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNG 912
REK+ Y L+++A D G LS+ + I D NDN P F + + E G
Sbjct: 426 REKRSEYSLTVIAEDRGTPSLSTVKHFTVQINDINDNPPHFQRSRYEFVI---SENNSPG 482
Query: 913 TAGFTIIEVKPKNKFALDVDQLGPL-FLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
T+ P D+ + G + + I E+ +G++I +D +G +R +
Sbjct: 483 AYITTVTATDP------DLGENGQVTYTILESFILGSSITTYVTIDPSNGAIYALRIFDH 536
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISV 1031
EV S+++ FV+ R G + L + L I +D NDN+ V
Sbjct: 537 EEV----SQIT---------FVVEARDGG--SPKQLVSNTTVVLTI--IDE---NDNVPV 576
Query: 1032 RVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDL 1091
+ P + + + + + ++ A D D G NA L+ I + +
Sbjct: 577 VI--------GPALRNNTAEITIPKGAESGFHVTRIRAIDRDSGVNAELSCAIVAGNEEN 628
Query: 1092 PFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
F I P + + N +D ++ L+V+ +D G
Sbjct: 629 IFIIDPRSCDIHTNVSMDSVPYTEWELSVIIQDKG 663
Score = 54.8 bits (126), Expect = 2e-06
Identities = 42/156 (26%), Positives = 73/156 (46%), Gaps = 24/156 (15%)
Query: 1226 NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHY 1285
++G+P S ++IL ++++D D + P F + Y +++ EN L+ LN T+
Sbjct: 221 DMGVPQRSGSSILKISISDSND-----NSPAFEQQSYIIQLLENSPVGTLLLDLNATDPD 275
Query: 1286 E--NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRE 1343
E N K+ Y + I TF ID G L L + D E+ +YE+ V+
Sbjct: 276 EGANGKIVYSFSSHVSPKIMETFKIDSERGHLTLFKQVDYEITKSYEIDVQ--------- 326
Query: 1344 LPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPK 1379
A+D+ K+++++ DVNDN P+
Sbjct: 327 --------AQDLGPNSIPAHCKIIIKVVDVNDNKPE 354
Score = 49.6 bits (113), Expect = 8e-05
Identities = 43/163 (26%), Positives = 73/163 (44%), Gaps = 10/163 (6%)
Query: 229 ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTA 288
+T+R+ + + L ++ NG + + +D E Q N ++ + P +
Sbjct: 63 STVRFRAMQRGNSPLLVVNEDNGEISIGATID--REQLCQKN-LNCSIEFDVITLPTEHL 119
Query: 289 QA-RVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD 347
Q +E+E+LD+NDN P+F I I E+ G + A D D GEN TY L
Sbjct: 120 QLFHIEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSL-S 178
Query: 348 PKGAFSIDPRSGWLTVRNQTV-----LDREAHSSLRMKVYAKE 385
F+I+ R+ + + LDRE SS +++ A +
Sbjct: 179 ANDFFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASD 221
Score = 46.8 bits (106), Expect = 6e-04
Identities = 45/171 (26%), Positives = 69/171 (40%), Gaps = 14/171 (8%)
Query: 993 VINERHGHVIVARSLPPESEFRLNISA---LDGGNLNDN----ISVRVFVKDVNDHFPVF 1045
V+NE +G + + ++ E + N++ D L + V V D+ND+ P F
Sbjct: 79 VVNEDNGEISIGATIDREQLCQKNLNCSIEFDVITLPTEHLQLFHIEVEVLDINDNSPQF 138
Query: 1046 KKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLT-----G 1100
++ + E+ + A D D G+N+ TY + +D E+ T
Sbjct: 139 SRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSANDF-FNIEVRTRTDGAKYA 197
Query: 1101 VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
L V ELDRE + Y L + A D G D NDNSP F
Sbjct: 198 ELIVVRELDRELKSSYELQLTASDMG-VPQRSGSSILKISISDSNDNSPAF 247
Score = 44.8 bits (101), Expect = 0.002
Identities = 38/153 (24%), Positives = 71/153 (46%), Gaps = 16/153 (10%)
Query: 218 IHAIDQDLGVGATLRYELIS----GNDRKLF-SLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A D DLG + Y ++ G+ + ++D NG+++ + D + + TF
Sbjct: 488 VTATDPDLGENGQVTYTILESFILGSSITTYVTIDPSNGAIYALRIFDHEEVSQI---TF 544
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLP-----EFEVDFYNISIVENLPNGFSVLQ 327
V++ + L + V + ++D NDN+P + I+I + +GF V +
Sbjct: 545 VVEARDGGSPKQL-VSNTTVVLTIIDENDNVPVVIGPALRNNTAEITIPKGAESGFHVTR 603
Query: 328 VMATDKDQGENGEFTYQL--DDPKGAFSIDPRS 358
+ A D+D G N E + + + + F IDPRS
Sbjct: 604 IRAIDRDSGVNAELSCAIVAGNEENIFIIDPRS 636
>BC093879-1|AAH93879.1| 818|Homo sapiens protocadherin gamma
subfamily B, 5 protein.
Length = 818
Score = 105 bits (253), Expect = 9e-22
Identities = 121/470 (25%), Positives = 196/470 (41%), Gaps = 39/470 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E ++F +V V + D ND+ P F N +E + +A+ GT A D D+G N +
Sbjct: 111 ENPLNFYHVNVEIEDINDHTPKFT-QNSFELQISESAQPGTRFILEVAEDADIGLNSLQK 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLA 553
Y L + ++ K + + E + + H L + A D P L
Sbjct: 170 YKLSLNPSFSLIIKEKQDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELR 229
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLL 611
I+VT + P P F Y + NV GT+V Q+ D E ++++Y
Sbjct: 230 ---IQVTDAN--DNP--PVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSF- 281
Query: 612 HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVND 671
Y G F++ +SG IT L Y V ++ L +++ D ND
Sbjct: 282 --YRTGQIFSLNSKSGEITTQKKLDFEETKEYSM-VVEGRDGGGLVAQCTVEINIQDEND 338
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
+ HS ++ + EN+ + + + NG N + Q +V I
Sbjct: 339 NSPEVT--FHS-LLEMILENAVPGTLIALIKIHDQDSGENGEVNCQL----QGEVPFKII 391
Query: 732 IAEDGT--IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
+ + + T LDRE+ Y +T+ A ++G + V ++I D NDN PVF
Sbjct: 392 SSSKNSYKLVTDGTLDREQTPEYNVTITAT-DRGKPPLSSSISVILHIRDVNDNAPVFHQ 450
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMF------DVDENT 843
A+Y + EN+ G I + A+D D G N Y++ E + +
Sbjct: 451 ASYLVSVPENNPPGASIAQ---VCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQS 507
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKP 891
GVV F + D E+ ++L+L ARD G LS+ L +++GD NDN P
Sbjct: 508 GVV-FAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAP 556
Score = 89.4 bits (212), Expect = 9e-17
Identities = 84/313 (26%), Positives = 139/313 (44%), Gaps = 23/313 (7%)
Query: 589 GTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN----RPMYD 644
G+ VG + + F ++ L E F V SG + V L R +P
Sbjct: 44 GSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVSAESGELLVSSRLDREEICGKKPACA 103
Query: 645 FEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTN 704
E A+ EN L+ + V + D+ND + + I S A G F
Sbjct: 104 LEFEAVAENP-LNFY-HVNVEIEDINDHTPKFTQNSFELQI------SESAQPGTRFILE 155
Query: 705 MSSIYGNGTGNV-RFLIANQQDVTDDIAIAEDGTIFTQ----KPLDREKRDVYRMTVIAE 759
++ G ++ ++ ++ + I +DG+ + + K LDRE++ +R+ V+
Sbjct: 156 VAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELALEKTLDREQQSYHRL-VLTA 214
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
+ G +G ++ I + D NDNPPVF Y + EN GT + + ATD DE
Sbjct: 215 LDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQ---VSATDQDE 271
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G N+ Y+ + G ++F ++ +G + LD E+ Y + + RD GGL ++ +
Sbjct: 272 GINSEITYSFYRTG-QIFSLNSKSGEIT-TQKKLDFEETKEYSMVVEGRDGGGLVAQCTV 329
Query: 880 IIMIGDENDNKPE 892
I I DENDN PE
Sbjct: 330 EINIQDENDNSPE 342
Score = 82.6 bits (195), Expect = 1e-14
Identities = 108/466 (23%), Positives = 200/466 (42%), Gaps = 44/466 (9%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L + + + DANDN PVF ++Y S++ N GT + +V A D D G N + Y
Sbjct: 222 LSGTTELRIQVTDANDNPPVF-NRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYS 280
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVT 556
RT + F +N +G ++ + E +++ VE D +A T
Sbjct: 281 FYRTGQI-----FSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGG-------LVAQCT 328
Query: 557 IEVT-RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN--DAFEQNDVSYDLLHG 613
+E+ + N P++ + E + N GT + I+++ D+ E +V+ L
Sbjct: 329 VEINIQDENDNSPEVT--FHSLLEM-ILENAVPGTLIALIKIHDQDSGENGEVNCQL--- 382
Query: 614 YEEGVPFAV--EERSGVITVVD-DLSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVDV 669
+ VPF + ++ V D L R P Y+ A LS + +H+ DV
Sbjct: 383 -QGEVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDV 441
Query: 670 NDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
ND V + ++ ++ + N GA+I Q+ +++ + NG + + ++ + +
Sbjct: 442 NDNAPVFHQASY--LVSVPENNPPGASIAQVCASDL-DLGLNGQVSYSIMASDLEPLALA 498
Query: 730 IAI---AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP- 785
+ A+ G +F Q+ D E+ + +T+ A ++G + + + + + D NDN P
Sbjct: 499 SYVSMSAQSGVVFAQRAFDYEQLRTFELTLQAR-DQGSPALSANVSLRVLVGDRNDNAPR 557
Query: 786 -VFEHATYEGFIMEN--SKIGTEIKMDNIIKATDADEGTNALFMY-TLFGEGKEMFDVDE 841
++ +G + + + + + A DAD G NA Y L +F +
Sbjct: 558 VLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGL 617
Query: 842 NTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
TG V+ DR+ +L + RD G LS+ A L ++ D
Sbjct: 618 RTGEVRTARALGDRD-AARQRLLVAVRDGGQPPLSATATLHLVFAD 662
Score = 81.8 bits (193), Expect = 2e-14
Identities = 53/166 (31%), Positives = 82/166 (49%), Gaps = 3/166 (1%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D+G+ + +Y+L L + +GS + E L+ + Q + L + A
Sbjct: 157 AEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELALEKTLDRE-QQSYHRLVLTAL 215
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
+P + + I++ D NDN P F D Y +S+ EN+P G +VLQV ATD+D+G N
Sbjct: 216 DGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINS 275
Query: 340 EFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
E TY FS++ +SG +T Q LD E M V ++
Sbjct: 276 EITYSFYRTGQIFSLNSKSGEIT--TQKKLDFEETKEYSMVVEGRD 319
Score = 74.9 bits (176), Expect = 2e-12
Identities = 68/239 (28%), Positives = 109/239 (45%), Gaps = 19/239 (7%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
I ++ +N + +V L +I EN GT I + D DSG NG++ + EV P
Sbjct: 331 INIQDENDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEVNCQLQGEV---P 387
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVK 1036
K+ + + Y ++ + + R PE + + I+A D G L+ +ISV + ++
Sbjct: 388 FKIISSSKN--SYKLVTDG----TLDREQTPE--YNVTITATDRGKPPLSSSISVILHIR 439
Query: 1037 DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTD-----L 1091
DVND+ PVF + Y +V E + +V A+D D G N ++Y I SD +
Sbjct: 440 DVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALAS 499
Query: 1092 PFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
+S +GV+ D E + LT+ ARD G D NDN+P+
Sbjct: 500 YVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQG-SPALSANVSLRVLVGDRNDNAPR 557
Score = 73.7 bits (173), Expect = 5e-12
Identities = 61/167 (36%), Positives = 83/167 (49%), Gaps = 12/167 (7%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP-VFEHAT 791
++ G I TQK LD E+ Y M V G+++ V I I+DENDN P V H+
Sbjct: 292 SKSGEITTQKKLDFEETKEYSMVVEGRDGGGLVAQC---TVEINIQDENDNSPEVTFHSL 348
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD 851
E I+EN+ GT I + IK D D G N L GE + + K + D
Sbjct: 349 LE-MILENAVPGTLIAL---IKIHDQDSGENGEVNCQLQGEVPFKI-ISSSKNSYKLVTD 403
Query: 852 -SLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+LDRE+ Y +++ A D G LSS +I+ I D NDN P F+Q
Sbjct: 404 GTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQ 450
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/169 (32%), Positives = 79/169 (46%), Gaps = 9/169 (5%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
AE G + LDRE+ + EF + Y V + IED ND+ P F ++
Sbjct: 79 AESGELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSF 138
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF---- 848
E I E+++ GT ++ A DAD G N+L Y L + E K+
Sbjct: 139 ELQISESAQPGTRFILE---VAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELA 195
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ 895
+ +LDRE++ ++L L A D G LS EL I + D NDN P FN+
Sbjct: 196 LEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNR 244
Score = 69.7 bits (163), Expect = 7e-11
Identities = 104/418 (24%), Positives = 182/418 (43%), Gaps = 45/418 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I E+ GT I A D D GLN +Y+ + + PS +L +K ++
Sbjct: 142 ISESAQPGTRFILEVAEDADIGLNSLQKYKLS----LNPSF----SLIIKEK-QDGSKYP 192
Query: 1000 HVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+ + ++L E + RL ++ALDGG+ L+ +R+ V D ND+ PVF + Y ++
Sbjct: 193 ELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLR 252
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E + +V ATD D G N+ +TY T F ++ +G ++ +LD E +
Sbjct: 253 ENVPPGTTVLQVSATDQDEGINSEITYSFY--RTGQIFSLNSKSGEITTQKKLDFEETKE 310
Query: 1116 YILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFES 1175
Y + V RD G D NDNSP+ F LLE A +
Sbjct: 311 YSMVVEGRDGG---GLVAQCTVEINIQDENDNSPE-VTFHSLLEMILENAVPGT-----L 361
Query: 1176 VMMIPVYKATIEENAPI-----GTTVAKVFA---NDTDFIGNGNGLILYSLPQRK---NQ 1224
+ +I ++ EN + G K+ + N + +G L P+
Sbjct: 362 IALIKIHDQDSGENGEVNCQLQGEVPFKIISSSKNSYKLVTDGT-LDREQTPEYNVTITA 420
Query: 1225 QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSLNLT 1282
+ G P LSS+ +++ + DV D + PVF Y + + EN A + V +
Sbjct: 421 TDRGKPPLSSSISVILHIRDVND-----NAPVFHQASYLVSVPENNPPGASIAQVCASDL 475
Query: 1283 EHYENFKMRYYIL-NENDTDIRRTFV-IDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
+ N ++ Y I+ ++ + ++V + ++G ++ R+ D E T+E+ ++A Q
Sbjct: 476 DLGLNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQ 533
Score = 68.9 bits (161), Expect = 1e-10
Identities = 70/221 (31%), Positives = 102/221 (46%), Gaps = 21/221 (9%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
I+ ++ N A Q L +PEN P G +I ++ A DLD GLNGQ+ Y I
Sbjct: 435 ILHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYS------IM 488
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRV 1033
S L + L + Y ++ + G V R+ E F L + A D G+ L+ N+S+RV
Sbjct: 489 ASDL--EPLALASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRV 546
Query: 1034 FVKDVNDHFP--VFKKTWYNFN-----VEEAQYTRRVLGKVDATDADFGQNANLTYFI-Q 1085
V D ND+ P ++ + + V A ++ KV A DAD G NA L+Y + Q
Sbjct: 547 LVGDRNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQ 606
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
S+ L F + TG + L + L V RD G
Sbjct: 607 ASEPGL-FSLGLRTGEVRTARALGDRDAARQRLLVAVRDGG 646
Score = 64.1 bits (149), Expect = 4e-09
Identities = 68/285 (23%), Positives = 113/285 (39%), Gaps = 15/285 (5%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L + G +S + + + D NDN P+F Y V++ E P G
Sbjct: 212 LTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDE 271
Query: 127 SLTIPLTVP--RGLTIF----KDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKP 180
+ +T R IF K + K + + + +V G D G + + +
Sbjct: 272 GINSEITYSFYRTGQIFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGGLVAQCTVE- 330
Query: 181 VLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND 240
+ ++ D L+ M + ++ IH DQD G + +L
Sbjct: 331 -INIQDENDNSPEVTFHSLLEMILENAVPGTLIALIKIH--DQDSGENGEVNCQLQGEVP 387
Query: 241 RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLN 300
K+ S S S L + LD E + N + + A+ P ++ V + + D+N
Sbjct: 388 FKIIS--SSKNSYKLVTDGTLDREQTPEYN---VTITATDRGKPPLSSSISVILHIRDVN 442
Query: 301 DNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
DN P F Y +S+ EN P G S+ QV A+D D G NG+ +Y +
Sbjct: 443 DNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSI 487
Score = 59.3 bits (137), Expect = 1e-07
Identities = 73/324 (22%), Positives = 133/324 (41%), Gaps = 35/324 (10%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP---------------I 124
+ V V IED+ND+ P F + + + E G + FI +A +
Sbjct: 116 FYHVNVEIEDINDHTPKFTQNSFELQISESAQPGTR-FILEVAEDADIGLNSLQKYKLSL 174
Query: 125 GPSLTIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLL 184
PS ++ + + + + ++ A ++ S H +++ D GH L + + + +
Sbjct: 175 NPSFSLIIKEKQDGSKYPEL-ALEKTLDREQQS-YHRLVLTALDGGHPPLSGTTELRIQV 232
Query: 185 RKVLDYD-AGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKL 243
D +++ V + +L + A DQD G+ + + Y ++
Sbjct: 233 TDANDNPPVFNRDVYRVSLRENVPPGTTVL---QVSATDQDEGINSEITYSFYRTG--QI 287
Query: 244 FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNL 303
FSL+S +G + +K+LD + + + + V+ + AQ VEI + D NDN
Sbjct: 288 FSLNSKSGEITTQKKLDFE-----ETKEYSMVVEGRDGGGLV--AQCTVEINIQDENDNS 340
Query: 304 PEFEVDFYNI--SIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWL 361
PE V F+++ I+EN G + + D+D GENGE QL I
Sbjct: 341 PE--VTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEVNCQLQGEVPFKIISSSKNSY 398
Query: 362 TVRNQTVLDREAHSSLRMKVYAKE 385
+ LDRE + + A +
Sbjct: 399 KLVTDGTLDREQTPEYNVTITATD 422
Score = 49.2 bits (112), Expect = 1e-04
Identities = 62/240 (25%), Positives = 103/240 (42%), Gaps = 29/240 (12%)
Query: 150 DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIH 209
D+ TP +V ++ D G L SS +L +R V D Q + S +
Sbjct: 407 DREQTPEYNV---TITATDRGKPPLSSSISVILHIRDV--NDNAPVFHQASYLVSVPENN 461
Query: 210 KEILFPEPIHAIDQDLGVGATLRYELISGNDRKL-----FSLDSVNGSLFLEKELDLDAE 264
+ A D DLG+ + Y +++ + L S+ + +G +F ++ D +
Sbjct: 462 PPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYE-- 519
Query: 265 HNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLPN 321
Q TF L +QA +P +A + + + D NDN P + ++ + +P
Sbjct: 520 ---QLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPR 576
Query: 322 ----GFSVLQVMATDKDQGENGEFTY---QLDDPKGAFSIDPRSGWLTVRNQTVL-DREA 373
G+ V +V+A D D G N +Y Q +P G FS+ R+G VR L DR+A
Sbjct: 577 AAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEP-GLFSLGLRTG--EVRTARALGDRDA 633
Score = 46.0 bits (104), Expect = 0.001
Identities = 63/225 (28%), Positives = 94/225 (41%), Gaps = 28/225 (12%)
Query: 938 FLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINER 997
+ IPE +P G+ + L A DL G + Q +P KL + K YF ++
Sbjct: 35 YRIPEEMPKGSVVGNL-ATDL--GFSVQ---------ELPTRKLRVSS--EKPYFTVSAE 80
Query: 998 HGHVIVARSLPPES------EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYN 1051
G ++V+ L E L A+ LN V V ++D+NDH P F + +
Sbjct: 81 SGELLVSSRLDREEICGKKPACALEFEAVAENPLNF-YHVNVEIEDINDHTPKFTQNSFE 139
Query: 1052 FNV-EEAQYTRRVLGKVDATDADFGQNANLTY--FIQPSDTDLPFEISPLTGV--LSVNG 1106
+ E AQ R + +V A DAD G N+ Y + PS + + E + L++
Sbjct: 140 LQISESAQPGTRFILEV-AEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELALEK 198
Query: 1107 ELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
LDRE + + L + A D G D NDN P F
Sbjct: 199 TLDREQQSYHRLVLTALDGG-HPPLSGTTELRIQVTDANDNPPVF 242
Score = 45.2 bits (102), Expect = 0.002
Identities = 43/160 (26%), Positives = 76/160 (47%), Gaps = 9/160 (5%)
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
+++ F++ + +G L + LD + E + L+ +A NPL VEIE D
Sbjct: 70 SEKPYFTVSAESGELLVSSRLDRE-EICGKKPACALEFEAVA-ENPLNFYHVNVEIE--D 125
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD-DPKGAFSIDPR 357
+ND+ P+F + + + I E+ G + +A D D G N Y+L +P + I +
Sbjct: 126 INDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEK 185
Query: 358 ---SGWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
S + + + LDRE S R+ + A + +P + GT
Sbjct: 186 QDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGT 225
>BC093877-1|AAH93877.1| 818|Homo sapiens protocadherin gamma
subfamily B, 5 protein.
Length = 818
Score = 105 bits (253), Expect = 9e-22
Identities = 121/470 (25%), Positives = 196/470 (41%), Gaps = 39/470 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E ++F +V V + D ND+ P F N +E + +A+ GT A D D+G N +
Sbjct: 111 ENPLNFYHVNVEIEDINDHTPKFT-QNSFELQISESAQPGTRFILEVAEDADIGLNSLQK 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLA 553
Y L + ++ K + + E + + H L + A D P L
Sbjct: 170 YKLSLNPSFSLIIKEKQDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELR 229
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLL 611
I+VT + P P F Y + NV GT+V Q+ D E ++++Y
Sbjct: 230 ---IQVTDAN--DNP--PVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSF- 281
Query: 612 HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVND 671
Y G F++ +SG IT L Y V ++ L +++ D ND
Sbjct: 282 --YRTGQIFSLNSKSGEITTQKKLDFEETKEYSM-VVEGRDGGGLVAQCTVEINIQDEND 338
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
+ HS ++ + EN+ + + + NG N + Q +V I
Sbjct: 339 NSPEVT--FHS-LLEMILENAVPGTLIALIKIHDQDSGENGEVNCQL----QGEVPFKII 391
Query: 732 IAEDGT--IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
+ + + T LDRE+ Y +T+ A ++G + V ++I D NDN PVF
Sbjct: 392 SSSKNSYKLVTDGTLDREQTPEYNVTITAT-DRGKPPLSSSISVILHIRDVNDNAPVFHQ 450
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMF------DVDENT 843
A+Y + EN+ G I + A+D D G N Y++ E + +
Sbjct: 451 ASYLVSVPENNPPGASIAQ---VCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQS 507
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKP 891
GVV F + D E+ ++L+L ARD G LS+ L +++GD NDN P
Sbjct: 508 GVV-FAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAP 556
Score = 89.4 bits (212), Expect = 9e-17
Identities = 84/313 (26%), Positives = 139/313 (44%), Gaps = 23/313 (7%)
Query: 589 GTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN----RPMYD 644
G+ VG + + F ++ L E F V SG + V L R +P
Sbjct: 44 GSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVSAESGELLVSSRLDREEICGKKPACA 103
Query: 645 FEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTN 704
E A+ EN L+ + V + D+ND + + I S A G F
Sbjct: 104 LEFEAVAENP-LNFY-HVNVEIEDINDHTPKFTQNSFELQI------SESAQPGTRFILE 155
Query: 705 MSSIYGNGTGNV-RFLIANQQDVTDDIAIAEDGTIFTQ----KPLDREKRDVYRMTVIAE 759
++ G ++ ++ ++ + I +DG+ + + K LDRE++ +R+ V+
Sbjct: 156 VAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELALEKTLDREQQSYHRL-VLTA 214
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
+ G +G ++ I + D NDNPPVF Y + EN GT + + ATD DE
Sbjct: 215 LDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQ---VSATDQDE 271
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G N+ Y+ + G ++F ++ +G + LD E+ Y + + RD GGL ++ +
Sbjct: 272 GINSEITYSFYRTG-QIFSLNSKSGEIT-TQKKLDFEETKEYSMVVEGRDGGGLVAQCTV 329
Query: 880 IIMIGDENDNKPE 892
I I DENDN PE
Sbjct: 330 EINIQDENDNSPE 342
Score = 82.6 bits (195), Expect = 1e-14
Identities = 108/466 (23%), Positives = 200/466 (42%), Gaps = 44/466 (9%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L + + + DANDN PVF ++Y S++ N GT + +V A D D G N + Y
Sbjct: 222 LSGTTELRIQVTDANDNPPVF-NRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYS 280
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVT 556
RT + F +N +G ++ + E +++ VE D +A T
Sbjct: 281 FYRTGQI-----FSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGG-------LVAQCT 328
Query: 557 IEVT-RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN--DAFEQNDVSYDLLHG 613
+E+ + N P++ + E + N GT + I+++ D+ E +V+ L
Sbjct: 329 VEINIQDENDNSPEVT--FHSLLEM-ILENAVPGTLIALIKIHDQDSGENGEVNCQL--- 382
Query: 614 YEEGVPFAV--EERSGVITVVD-DLSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVDV 669
+ VPF + ++ V D L R P Y+ A LS + +H+ DV
Sbjct: 383 -QGEVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDV 441
Query: 670 NDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
ND V + ++ ++ + N GA+I Q+ +++ + NG + + ++ + +
Sbjct: 442 NDNAPVFHQASY--LVSVPENNPPGASIAQVCASDL-DLGLNGQVSYSIMASDLEPLALA 498
Query: 730 IAI---AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP- 785
+ A+ G +F Q+ D E+ + +T+ A ++G + + + + + D NDN P
Sbjct: 499 SYVSMSAQSGVVFAQRAFDYEQLRTFELTLQAR-DQGSPALSANVSLRVLVGDRNDNAPR 557
Query: 786 -VFEHATYEGFIMEN--SKIGTEIKMDNIIKATDADEGTNALFMY-TLFGEGKEMFDVDE 841
++ +G + + + + + A DAD G NA Y L +F +
Sbjct: 558 VLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGL 617
Query: 842 NTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
TG V+ DR+ +L + RD G LS+ A L ++ D
Sbjct: 618 RTGEVRTARALGDRD-AARQRLLVAVRDGGQPPLSATATLHLVFAD 662
Score = 81.8 bits (193), Expect = 2e-14
Identities = 53/166 (31%), Positives = 82/166 (49%), Gaps = 3/166 (1%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D+G+ + +Y+L L + +GS + E L+ + Q + L + A
Sbjct: 157 AEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELALEKTLDRE-QQSYHRLVLTAL 215
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
+P + + I++ D NDN P F D Y +S+ EN+P G +VLQV ATD+D+G N
Sbjct: 216 DGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINS 275
Query: 340 EFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
E TY FS++ +SG +T Q LD E M V ++
Sbjct: 276 EITYSFYRTGQIFSLNSKSGEIT--TQKKLDFEETKEYSMVVEGRD 319
Score = 74.9 bits (176), Expect = 2e-12
Identities = 68/239 (28%), Positives = 109/239 (45%), Gaps = 19/239 (7%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
I ++ +N + +V L +I EN GT I + D DSG NG++ + EV P
Sbjct: 331 INIQDENDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEVNCQLQGEV---P 387
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVK 1036
K+ + + Y ++ + + R PE + + I+A D G L+ +ISV + ++
Sbjct: 388 FKIISSSKN--SYKLVTDG----TLDREQTPE--YNVTITATDRGKPPLSSSISVILHIR 439
Query: 1037 DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTD-----L 1091
DVND+ PVF + Y +V E + +V A+D D G N ++Y I SD +
Sbjct: 440 DVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALAS 499
Query: 1092 PFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
+S +GV+ D E + LT+ ARD G D NDN+P+
Sbjct: 500 YVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQG-SPALSANVSLRVLVGDRNDNAPR 557
Score = 73.7 bits (173), Expect = 5e-12
Identities = 61/167 (36%), Positives = 83/167 (49%), Gaps = 12/167 (7%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP-VFEHAT 791
++ G I TQK LD E+ Y M V G+++ V I I+DENDN P V H+
Sbjct: 292 SKSGEITTQKKLDFEETKEYSMVVEGRDGGGLVAQC---TVEINIQDENDNSPEVTFHSL 348
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD 851
E I+EN+ GT I + IK D D G N L GE + + K + D
Sbjct: 349 LE-MILENAVPGTLIAL---IKIHDQDSGENGEVNCQLQGEVPFKI-ISSSKNSYKLVTD 403
Query: 852 -SLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+LDRE+ Y +++ A D G LSS +I+ I D NDN P F+Q
Sbjct: 404 GTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQ 450
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/169 (32%), Positives = 79/169 (46%), Gaps = 9/169 (5%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
AE G + LDRE+ + EF + Y V + IED ND+ P F ++
Sbjct: 79 AESGELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSF 138
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF---- 848
E I E+++ GT ++ A DAD G N+L Y L + E K+
Sbjct: 139 ELQISESAQPGTRFILE---VAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELA 195
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ 895
+ +LDRE++ ++L L A D G LS EL I + D NDN P FN+
Sbjct: 196 LEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNR 244
Score = 69.7 bits (163), Expect = 7e-11
Identities = 104/418 (24%), Positives = 182/418 (43%), Gaps = 45/418 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I E+ GT I A D D GLN +Y+ + + PS +L +K ++
Sbjct: 142 ISESAQPGTRFILEVAEDADIGLNSLQKYKLS----LNPSF----SLIIKEK-QDGSKYP 192
Query: 1000 HVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+ + ++L E + RL ++ALDGG+ L+ +R+ V D ND+ PVF + Y ++
Sbjct: 193 ELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLR 252
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E + +V ATD D G N+ +TY T F ++ +G ++ +LD E +
Sbjct: 253 ENVPPGTTVLQVSATDQDEGINSEITYSFY--RTGQIFSLNSKSGEITTQKKLDFEETKE 310
Query: 1116 YILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFES 1175
Y + V RD G D NDNSP+ F LLE A +
Sbjct: 311 YSMVVEGRDGG---GLVAQCTVEINIQDENDNSPE-VTFHSLLEMILENAVPGT-----L 361
Query: 1176 VMMIPVYKATIEENAPI-----GTTVAKVFA---NDTDFIGNGNGLILYSLPQRK---NQ 1224
+ +I ++ EN + G K+ + N + +G L P+
Sbjct: 362 IALIKIHDQDSGENGEVNCQLQGEVPFKIISSSKNSYKLVTDGT-LDREQTPEYNVTITA 420
Query: 1225 QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSLNLT 1282
+ G P LSS+ +++ + DV D + PVF Y + + EN A + V +
Sbjct: 421 TDRGKPPLSSSISVILHIRDVND-----NAPVFHQASYLVSVPENNPPGASIAQVCASDL 475
Query: 1283 EHYENFKMRYYIL-NENDTDIRRTFV-IDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
+ N ++ Y I+ ++ + ++V + ++G ++ R+ D E T+E+ ++A Q
Sbjct: 476 DLGLNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQ 533
Score = 68.9 bits (161), Expect = 1e-10
Identities = 70/221 (31%), Positives = 102/221 (46%), Gaps = 21/221 (9%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
I+ ++ N A Q L +PEN P G +I ++ A DLD GLNGQ+ Y I
Sbjct: 435 ILHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYS------IM 488
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRV 1033
S L + L + Y ++ + G V R+ E F L + A D G+ L+ N+S+RV
Sbjct: 489 ASDL--EPLALASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRV 546
Query: 1034 FVKDVNDHFP--VFKKTWYNFN-----VEEAQYTRRVLGKVDATDADFGQNANLTYFI-Q 1085
V D ND+ P ++ + + V A ++ KV A DAD G NA L+Y + Q
Sbjct: 547 LVGDRNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQ 606
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
S+ L F + TG + L + L V RD G
Sbjct: 607 ASEPGL-FSLGLRTGEVRTARALGDRDAARQRLLVAVRDGG 646
Score = 64.1 bits (149), Expect = 4e-09
Identities = 68/285 (23%), Positives = 113/285 (39%), Gaps = 15/285 (5%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L + G +S + + + D NDN P+F Y V++ E P G
Sbjct: 212 LTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDE 271
Query: 127 SLTIPLTVP--RGLTIF----KDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKP 180
+ +T R IF K + K + + + +V G D G + + +
Sbjct: 272 GINSEITYSFYRTGQIFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGGLVAQCTVE- 330
Query: 181 VLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND 240
+ ++ D L+ M + ++ IH DQD G + +L
Sbjct: 331 -INIQDENDNSPEVTFHSLLEMILENAVPGTLIALIKIH--DQDSGENGEVNCQLQGEVP 387
Query: 241 RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLN 300
K+ S S S L + LD E + N + + A+ P ++ V + + D+N
Sbjct: 388 FKIIS--SSKNSYKLVTDGTLDREQTPEYN---VTITATDRGKPPLSSSISVILHIRDVN 442
Query: 301 DNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
DN P F Y +S+ EN P G S+ QV A+D D G NG+ +Y +
Sbjct: 443 DNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSI 487
Score = 59.3 bits (137), Expect = 1e-07
Identities = 73/324 (22%), Positives = 133/324 (41%), Gaps = 35/324 (10%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP---------------I 124
+ V V IED+ND+ P F + + + E G + FI +A +
Sbjct: 116 FYHVNVEIEDINDHTPKFTQNSFELQISESAQPGTR-FILEVAEDADIGLNSLQKYKLSL 174
Query: 125 GPSLTIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLL 184
PS ++ + + + + ++ A ++ S H +++ D GH L + + + +
Sbjct: 175 NPSFSLIIKEKQDGSKYPEL-ALEKTLDREQQS-YHRLVLTALDGGHPPLSGTTELRIQV 232
Query: 185 RKVLDYD-AGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKL 243
D +++ V + +L + A DQD G+ + + Y ++
Sbjct: 233 TDANDNPPVFNRDVYRVSLRENVPPGTTVL---QVSATDQDEGINSEITYSFYRTG--QI 287
Query: 244 FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNL 303
FSL+S +G + +K+LD + + + + V+ + AQ VEI + D NDN
Sbjct: 288 FSLNSKSGEITTQKKLDFE-----ETKEYSMVVEGRDGGGLV--AQCTVEINIQDENDNS 340
Query: 304 PEFEVDFYNI--SIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWL 361
PE V F+++ I+EN G + + D+D GENGE QL I
Sbjct: 341 PE--VTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEVNCQLQGEVPFKIISSSKNSY 398
Query: 362 TVRNQTVLDREAHSSLRMKVYAKE 385
+ LDRE + + A +
Sbjct: 399 KLVTDGTLDREQTPEYNVTITATD 422
Score = 49.2 bits (112), Expect = 1e-04
Identities = 62/240 (25%), Positives = 103/240 (42%), Gaps = 29/240 (12%)
Query: 150 DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIH 209
D+ TP +V ++ D G L SS +L +R V D Q + S +
Sbjct: 407 DREQTPEYNV---TITATDRGKPPLSSSISVILHIRDV--NDNAPVFHQASYLVSVPENN 461
Query: 210 KEILFPEPIHAIDQDLGVGATLRYELISGNDRKL-----FSLDSVNGSLFLEKELDLDAE 264
+ A D DLG+ + Y +++ + L S+ + +G +F ++ D +
Sbjct: 462 PPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYE-- 519
Query: 265 HNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLPN 321
Q TF L +QA +P +A + + + D NDN P + ++ + +P
Sbjct: 520 ---QLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPR 576
Query: 322 ----GFSVLQVMATDKDQGENGEFTY---QLDDPKGAFSIDPRSGWLTVRNQTVL-DREA 373
G+ V +V+A D D G N +Y Q +P G FS+ R+G VR L DR+A
Sbjct: 577 AAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEP-GLFSLGLRTG--EVRTARALGDRDA 633
Score = 46.0 bits (104), Expect = 0.001
Identities = 63/225 (28%), Positives = 94/225 (41%), Gaps = 28/225 (12%)
Query: 938 FLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINER 997
+ IPE +P G+ + L A DL G + Q +P KL + K YF ++
Sbjct: 35 YRIPEEMPKGSVVGNL-ATDL--GFSVQ---------ELPTRKLRVSS--EKPYFTVSAE 80
Query: 998 HGHVIVARSLPPES------EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYN 1051
G ++V+ L E L A+ LN V V ++D+NDH P F + +
Sbjct: 81 SGELLVSSRLDREEICGKKPACALEFEAVAENPLNF-YHVNVEIEDINDHTPKFTQNSFE 139
Query: 1052 FNV-EEAQYTRRVLGKVDATDADFGQNANLTY--FIQPSDTDLPFEISPLTGV--LSVNG 1106
+ E AQ R + +V A DAD G N+ Y + PS + + E + L++
Sbjct: 140 LQISESAQPGTRFILEV-AEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELALEK 198
Query: 1107 ELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
LDRE + + L + A D G D NDN P F
Sbjct: 199 TLDREQQSYHRLVLTALDGG-HPPLSGTTELRIQVTDANDNPPVF 242
Score = 45.2 bits (102), Expect = 0.002
Identities = 43/160 (26%), Positives = 76/160 (47%), Gaps = 9/160 (5%)
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
+++ F++ + +G L + LD + E + L+ +A NPL VEIE D
Sbjct: 70 SEKPYFTVSAESGELLVSSRLDRE-EICGKKPACALEFEAVA-ENPLNFYHVNVEIE--D 125
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD-DPKGAFSIDPR 357
+ND+ P+F + + + I E+ G + +A D D G N Y+L +P + I +
Sbjct: 126 INDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEK 185
Query: 358 ---SGWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
S + + + LDRE S R+ + A + +P + GT
Sbjct: 186 QDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGT 225
>AF152521-1|AAD43781.1| 818|Homo sapiens protocadherin gamma B5
short form protein protein.
Length = 818
Score = 105 bits (253), Expect = 9e-22
Identities = 121/470 (25%), Positives = 196/470 (41%), Gaps = 39/470 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E ++F +V V + D ND+ P F N +E + +A+ GT A D D+G N +
Sbjct: 111 ENPLNFYHVNVEIEDINDHTPKFT-QNSFELQISESAQPGTRFILEVAEDADIGLNSLQK 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLA 553
Y L + ++ K + + E + + H L + A D P L
Sbjct: 170 YKLSLNPSFSLIIKEKQDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELR 229
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLL 611
I+VT + P P F Y + NV GT+V Q+ D E ++++Y
Sbjct: 230 ---IQVTDAN--DNP--PVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSF- 281
Query: 612 HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVND 671
Y G F++ +SG IT L Y V ++ L +++ D ND
Sbjct: 282 --YRTGQIFSLNSKSGEITTQKKLDFEETKEYSM-VVEGRDGGGLVAQCTVEINIQDEND 338
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
+ HS ++ + EN+ + + + NG N + Q +V I
Sbjct: 339 NSPEVT--FHS-LLEMILENAVPGTLIALIKIHDQDSGENGEVNCQL----QGEVPFKII 391
Query: 732 IAEDGT--IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
+ + + T LDRE+ Y +T+ A ++G + V ++I D NDN PVF
Sbjct: 392 SSSKNSYKLVTDGTLDREQTPEYNVTITAT-DRGKPPLSSSISVILHIRDVNDNAPVFHQ 450
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMF------DVDENT 843
A+Y + EN+ G I + A+D D G N Y++ E + +
Sbjct: 451 ASYLVSVPENNPPGASIAQ---VCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQS 507
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKP 891
GVV F + D E+ ++L+L ARD G LS+ L +++GD NDN P
Sbjct: 508 GVV-FAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAP 556
Score = 89.4 bits (212), Expect = 9e-17
Identities = 84/313 (26%), Positives = 139/313 (44%), Gaps = 23/313 (7%)
Query: 589 GTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN----RPMYD 644
G+ VG + + F ++ L E F V SG + V L R +P
Sbjct: 44 GSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVSAESGELLVSSRLDREEICGKKPACA 103
Query: 645 FEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTN 704
E A+ EN L+ + V + D+ND + + I S A G F
Sbjct: 104 LEFEAVAENP-LNFY-HVNVEIEDINDHTPKFTQNSFELQI------SESAQPGTRFILE 155
Query: 705 MSSIYGNGTGNV-RFLIANQQDVTDDIAIAEDGTIFTQ----KPLDREKRDVYRMTVIAE 759
++ G ++ ++ ++ + I +DG+ + + K LDRE++ +R+ V+
Sbjct: 156 VAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELALEKTLDREQQSYHRL-VLTA 214
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
+ G +G ++ I + D NDNPPVF Y + EN GT + + ATD DE
Sbjct: 215 LDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQ---VSATDQDE 271
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G N+ Y+ + G ++F ++ +G + LD E+ Y + + RD GGL ++ +
Sbjct: 272 GINSEITYSFYRTG-QIFSLNSKSGEIT-TQKKLDFEETKEYSMVVEGRDGGGLVAQCTV 329
Query: 880 IIMIGDENDNKPE 892
I I DENDN PE
Sbjct: 330 EINIQDENDNSPE 342
Score = 82.6 bits (195), Expect = 1e-14
Identities = 108/466 (23%), Positives = 200/466 (42%), Gaps = 44/466 (9%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L + + + DANDN PVF ++Y S++ N GT + +V A D D G N + Y
Sbjct: 222 LSGTTELRIQVTDANDNPPVF-NRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYS 280
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVT 556
RT + F +N +G ++ + E +++ VE D +A T
Sbjct: 281 FYRTGQI-----FSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGG-------LVAQCT 328
Query: 557 IEVT-RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN--DAFEQNDVSYDLLHG 613
+E+ + N P++ + E + N GT + I+++ D+ E +V+ L
Sbjct: 329 VEINIQDENDNSPEVT--FHSLLEM-ILENAVPGTLIALIKIHDQDSGENGEVNCQL--- 382
Query: 614 YEEGVPFAV--EERSGVITVVD-DLSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVDV 669
+ VPF + ++ V D L R P Y+ A LS + +H+ DV
Sbjct: 383 -QGEVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDV 441
Query: 670 NDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
ND V + ++ ++ + N GA+I Q+ +++ + NG + + ++ + +
Sbjct: 442 NDNAPVFHQASY--LVSVPENNPPGASIAQVCASDL-DLGLNGQVSYSIMASDLEPLALA 498
Query: 730 IAI---AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP- 785
+ A+ G +F Q+ D E+ + +T+ A ++G + + + + + D NDN P
Sbjct: 499 SYVSMSAQSGVVFAQRAFDYEQLRTFELTLQAR-DQGSPALSANVSLRVLVGDRNDNAPR 557
Query: 786 -VFEHATYEGFIMEN--SKIGTEIKMDNIIKATDADEGTNALFMY-TLFGEGKEMFDVDE 841
++ +G + + + + + A DAD G NA Y L +F +
Sbjct: 558 VLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGL 617
Query: 842 NTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
TG V+ DR+ +L + RD G LS+ A L ++ D
Sbjct: 618 RTGEVRTARALGDRD-AARQRLLVAVRDGGQPPLSATATLHLVFAD 662
Score = 81.8 bits (193), Expect = 2e-14
Identities = 53/166 (31%), Positives = 82/166 (49%), Gaps = 3/166 (1%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D+G+ + +Y+L L + +GS + E L+ + Q + L + A
Sbjct: 157 AEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELALEKTLDRE-QQSYHRLVLTAL 215
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
+P + + I++ D NDN P F D Y +S+ EN+P G +VLQV ATD+D+G N
Sbjct: 216 DGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINS 275
Query: 340 EFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
E TY FS++ +SG +T Q LD E M V ++
Sbjct: 276 EITYSFYRTGQIFSLNSKSGEIT--TQKKLDFEETKEYSMVVEGRD 319
Score = 74.9 bits (176), Expect = 2e-12
Identities = 68/239 (28%), Positives = 109/239 (45%), Gaps = 19/239 (7%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
I ++ +N + +V L +I EN GT I + D DSG NG++ + EV P
Sbjct: 331 INIQDENDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEVNCQLQGEV---P 387
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVK 1036
K+ + + Y ++ + + R PE + + I+A D G L+ +ISV + ++
Sbjct: 388 FKIISSSKN--SYKLVTDG----TLDREQTPE--YNVTITATDRGKPPLSSSISVILHIR 439
Query: 1037 DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTD-----L 1091
DVND+ PVF + Y +V E + +V A+D D G N ++Y I SD +
Sbjct: 440 DVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALAS 499
Query: 1092 PFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
+S +GV+ D E + LT+ ARD G D NDN+P+
Sbjct: 500 YVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQG-SPALSANVSLRVLVGDRNDNAPR 557
Score = 73.7 bits (173), Expect = 5e-12
Identities = 61/167 (36%), Positives = 83/167 (49%), Gaps = 12/167 (7%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP-VFEHAT 791
++ G I TQK LD E+ Y M V G+++ V I I+DENDN P V H+
Sbjct: 292 SKSGEITTQKKLDFEETKEYSMVVEGRDGGGLVAQC---TVEINIQDENDNSPEVTFHSL 348
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD 851
E I+EN+ GT I + IK D D G N L GE + + K + D
Sbjct: 349 LE-MILENAVPGTLIAL---IKIHDQDSGENGEVNCQLQGEVPFKI-ISSSKNSYKLVTD 403
Query: 852 -SLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+LDRE+ Y +++ A D G LSS +I+ I D NDN P F+Q
Sbjct: 404 GTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQ 450
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/169 (32%), Positives = 79/169 (46%), Gaps = 9/169 (5%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
AE G + LDRE+ + EF + Y V + IED ND+ P F ++
Sbjct: 79 AESGELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSF 138
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF---- 848
E I E+++ GT ++ A DAD G N+L Y L + E K+
Sbjct: 139 ELQISESAQPGTRFILE---VAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELA 195
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ 895
+ +LDRE++ ++L L A D G LS EL I + D NDN P FN+
Sbjct: 196 LEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNR 244
Score = 69.7 bits (163), Expect = 7e-11
Identities = 104/418 (24%), Positives = 182/418 (43%), Gaps = 45/418 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I E+ GT I A D D GLN +Y+ + + PS +L +K ++
Sbjct: 142 ISESAQPGTRFILEVAEDADIGLNSLQKYKLS----LNPSF----SLIIKEK-QDGSKYP 192
Query: 1000 HVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+ + ++L E + RL ++ALDGG+ L+ +R+ V D ND+ PVF + Y ++
Sbjct: 193 ELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLR 252
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E + +V ATD D G N+ +TY T F ++ +G ++ +LD E +
Sbjct: 253 ENVPPGTTVLQVSATDQDEGINSEITYSFY--RTGQIFSLNSKSGEITTQKKLDFEETKE 310
Query: 1116 YILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFES 1175
Y + V RD G D NDNSP+ F LLE A +
Sbjct: 311 YSMVVEGRDGG---GLVAQCTVEINIQDENDNSPE-VTFHSLLEMILENAVPGT-----L 361
Query: 1176 VMMIPVYKATIEENAPI-----GTTVAKVFA---NDTDFIGNGNGLILYSLPQRK---NQ 1224
+ +I ++ EN + G K+ + N + +G L P+
Sbjct: 362 IALIKIHDQDSGENGEVNCQLQGEVPFKIISSSKNSYKLVTDGT-LDREQTPEYNVTITA 420
Query: 1225 QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSLNLT 1282
+ G P LSS+ +++ + DV D + PVF Y + + EN A + V +
Sbjct: 421 TDRGKPPLSSSISVILHIRDVND-----NAPVFHQASYLVSVPENNPPGASIAQVCASDL 475
Query: 1283 EHYENFKMRYYIL-NENDTDIRRTFV-IDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
+ N ++ Y I+ ++ + ++V + ++G ++ R+ D E T+E+ ++A Q
Sbjct: 476 DLGLNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQ 533
Score = 68.9 bits (161), Expect = 1e-10
Identities = 70/221 (31%), Positives = 102/221 (46%), Gaps = 21/221 (9%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
I+ ++ N A Q L +PEN P G +I ++ A DLD GLNGQ+ Y I
Sbjct: 435 ILHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYS------IM 488
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRV 1033
S L + L + Y ++ + G V R+ E F L + A D G+ L+ N+S+RV
Sbjct: 489 ASDL--EPLALASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRV 546
Query: 1034 FVKDVNDHFP--VFKKTWYNFN-----VEEAQYTRRVLGKVDATDADFGQNANLTYFI-Q 1085
V D ND+ P ++ + + V A ++ KV A DAD G NA L+Y + Q
Sbjct: 547 LVGDRNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQ 606
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
S+ L F + TG + L + L V RD G
Sbjct: 607 ASEPGL-FSLGLRTGEVRTARALGDRDAARQRLLVAVRDGG 646
Score = 64.1 bits (149), Expect = 4e-09
Identities = 68/285 (23%), Positives = 113/285 (39%), Gaps = 15/285 (5%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L + G +S + + + D NDN P+F Y V++ E P G
Sbjct: 212 LTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDE 271
Query: 127 SLTIPLTVP--RGLTIF----KDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKP 180
+ +T R IF K + K + + + +V G D G + + +
Sbjct: 272 GINSEITYSFYRTGQIFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGGLVAQCTVE- 330
Query: 181 VLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND 240
+ ++ D L+ M + ++ IH DQD G + +L
Sbjct: 331 -INIQDENDNSPEVTFHSLLEMILENAVPGTLIALIKIH--DQDSGENGEVNCQLQGEVP 387
Query: 241 RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLN 300
K+ S S S L + LD E + N + + A+ P ++ V + + D+N
Sbjct: 388 FKIIS--SSKNSYKLVTDGTLDREQTPEYN---VTITATDRGKPPLSSSISVILHIRDVN 442
Query: 301 DNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
DN P F Y +S+ EN P G S+ QV A+D D G NG+ +Y +
Sbjct: 443 DNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSI 487
Score = 59.3 bits (137), Expect = 1e-07
Identities = 73/324 (22%), Positives = 133/324 (41%), Gaps = 35/324 (10%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP---------------I 124
+ V V IED+ND+ P F + + + E G + FI +A +
Sbjct: 116 FYHVNVEIEDINDHTPKFTQNSFELQISESAQPGTR-FILEVAEDADIGLNSLQKYKLSL 174
Query: 125 GPSLTIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLL 184
PS ++ + + + + ++ A ++ S H +++ D GH L + + + +
Sbjct: 175 NPSFSLIIKEKQDGSKYPEL-ALEKTLDREQQS-YHRLVLTALDGGHPPLSGTTELRIQV 232
Query: 185 RKVLDYD-AGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKL 243
D +++ V + +L + A DQD G+ + + Y ++
Sbjct: 233 TDANDNPPVFNRDVYRVSLRENVPPGTTVL---QVSATDQDEGINSEITYSFYRTG--QI 287
Query: 244 FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNL 303
FSL+S +G + +K+LD + + + + V+ + AQ VEI + D NDN
Sbjct: 288 FSLNSKSGEITTQKKLDFE-----ETKEYSMVVEGRDGGGLV--AQCTVEINIQDENDNS 340
Query: 304 PEFEVDFYNI--SIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWL 361
PE V F+++ I+EN G + + D+D GENGE QL I
Sbjct: 341 PE--VTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEVNCQLQGEVPFKIISSSKNSY 398
Query: 362 TVRNQTVLDREAHSSLRMKVYAKE 385
+ LDRE + + A +
Sbjct: 399 KLVTDGTLDREQTPEYNVTITATD 422
Score = 49.2 bits (112), Expect = 1e-04
Identities = 62/240 (25%), Positives = 103/240 (42%), Gaps = 29/240 (12%)
Query: 150 DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIH 209
D+ TP +V ++ D G L SS +L +R V D Q + S +
Sbjct: 407 DREQTPEYNV---TITATDRGKPPLSSSISVILHIRDV--NDNAPVFHQASYLVSVPENN 461
Query: 210 KEILFPEPIHAIDQDLGVGATLRYELISGNDRKL-----FSLDSVNGSLFLEKELDLDAE 264
+ A D DLG+ + Y +++ + L S+ + +G +F ++ D +
Sbjct: 462 PPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYE-- 519
Query: 265 HNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLPN 321
Q TF L +QA +P +A + + + D NDN P + ++ + +P
Sbjct: 520 ---QLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPR 576
Query: 322 ----GFSVLQVMATDKDQGENGEFTY---QLDDPKGAFSIDPRSGWLTVRNQTVL-DREA 373
G+ V +V+A D D G N +Y Q +P G FS+ R+G VR L DR+A
Sbjct: 577 AAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEP-GLFSLGLRTG--EVRTARALGDRDA 633
Score = 46.0 bits (104), Expect = 0.001
Identities = 63/225 (28%), Positives = 94/225 (41%), Gaps = 28/225 (12%)
Query: 938 FLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINER 997
+ IPE +P G+ + L A DL G + Q +P KL + K YF ++
Sbjct: 35 YRIPEEMPKGSVVGNL-ATDL--GFSVQ---------ELPTRKLRVSS--EKPYFTVSAE 80
Query: 998 HGHVIVARSLPPES------EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYN 1051
G ++V+ L E L A+ LN V V ++D+NDH P F + +
Sbjct: 81 SGELLVSSRLDREEICGKKPACALEFEAVAENPLNF-YHVNVEIEDINDHTPKFTQNSFE 139
Query: 1052 FNV-EEAQYTRRVLGKVDATDADFGQNANLTY--FIQPSDTDLPFEISPLTGV--LSVNG 1106
+ E AQ R + +V A DAD G N+ Y + PS + + E + L++
Sbjct: 140 LQISESAQPGTRFILEV-AEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELALEK 198
Query: 1107 ELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
LDRE + + L + A D G D NDN P F
Sbjct: 199 TLDREQQSYHRLVLTALDGG-HPPLSGTTELRIQVTDANDNPPVF 242
Score = 45.2 bits (102), Expect = 0.002
Identities = 43/160 (26%), Positives = 76/160 (47%), Gaps = 9/160 (5%)
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
+++ F++ + +G L + LD + E + L+ +A NPL VEIE D
Sbjct: 70 SEKPYFTVSAESGELLVSSRLDRE-EICGKKPACALEFEAVA-ENPLNFYHVNVEIE--D 125
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD-DPKGAFSIDPR 357
+ND+ P+F + + + I E+ G + +A D D G N Y+L +P + I +
Sbjct: 126 INDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEK 185
Query: 358 ---SGWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
S + + + LDRE S R+ + A + +P + GT
Sbjct: 186 QDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGT 225
>AF152514-1|AAD43774.1| 817|Homo sapiens protocadherin gamma A7
short form protein protein.
Length = 817
Score = 105 bits (253), Expect = 9e-22
Identities = 117/478 (24%), Positives = 193/478 (40%), Gaps = 37/478 (7%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
N E M+ ++V ++D NDN P F+ + + N G +A DPD+G
Sbjct: 105 NFNILMEDKMNLYPIDVEIIDINDNVPRFLTEEI-NVKIMENTAPGVRFPLSEAGDPDVG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSE 547
N + Y L + ++ + V E + E H L + ASD P
Sbjct: 164 TNSLQSYQLSPNRHFSLAVQSGDDETKYPELVLERVLDREEERVHHLVLTASDGGDPPRS 223
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVS 607
+ V ++V T P F Y+ V NV +GT + + D E V+
Sbjct: 224 STAHIQVTVVDVNDHT-------PVFSLPQYQVTVPENVPVGTRLLTVHAIDLDE--GVN 274
Query: 608 YDLLHGYEEGVP-----FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNA 662
++ + + + P F + +G I+ ++ L Y+ E A Q+
Sbjct: 275 GEVTYSFRKITPKLPKMFHLNSLTGEISTLEGLDYEETAFYEMEVQA-QDGPGSLTKAKV 333
Query: 663 TVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIAN 722
+ V+DVND + + S I ++ G I + + S G V I
Sbjct: 334 LITVLDVNDNAPEVTMTSLSSSI--PEDTPLGTVIALFYLQDRDS---GKNGEVTCTIPE 388
Query: 723 QQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEND 782
+ +I + T K LDRE +Y +T+ A + G + + + + D ND
Sbjct: 389 NLPFKLEKSIDNYYRLVTTKNLDRETLSLYNITLKAT-DGGTPPLSRETHIFMQVADTND 447
Query: 783 NPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEM 836
NPP F H++Y +I EN+ G I ++ A D D NA Y+L +
Sbjct: 448 NPPTFPHSSYSVYIAENNPRGASI---FLVTAQDHDSEDNAQITYSLAEDTIQGAPVSSY 504
Query: 837 FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
++ +TGV+ + S D E+ +L + A D+G LSS L + + D+NDN PE
Sbjct: 505 VSINSDTGVL-YALQSFDYEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPE 561
Score = 78.6 bits (185), Expect = 2e-13
Identities = 61/217 (28%), Positives = 93/217 (42%), Gaps = 20/217 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN+P+GT ++ ++A+DLD G+NG++ Y F I P ++ + F +N G
Sbjct: 251 VPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRK---ITP--------KLPKMFHLNSLTG 299
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ L E + + + A DG V + V DVND+ P T + ++ E
Sbjct: 300 EISTLEGLDYEETAFYEMEVQAQDGPGSLTKAKVLITVLDVNDNAPEVTMTSLSSSIPED 359
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
V+ D D G+N +T I +LPF++ L LDRET
Sbjct: 360 TPLGTVIALFYLQDRDSGKNGEVTCTI---PENLPFKLEKSIDNYYRLVTTKNLDRETLS 416
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
Y +T+ A D G D NDN P F
Sbjct: 417 LYNITLKATDGG-TPPLSRETHIFMQVADTNDNPPTF 452
Score = 75.4 bits (177), Expect = 1e-12
Identities = 81/352 (23%), Positives = 157/352 (44%), Gaps = 38/352 (10%)
Query: 574 MGAPYEFWVG-------SNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVP--FAVEE 624
+G P+E W G G+ VG I + E +++ + G FA+ +
Sbjct: 20 LGTPWEAWAGRILYSVSEETDKGSFVGDIAKDLGLEPRELAERGVRIISRGRTQLFALNQ 79
Query: 625 RSGVITVVDDLSRYN------RPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLK 678
RSG + + R R + +F + +++ NL + V ++D+ND L
Sbjct: 80 RSGSLVTAGRIDREEICAQSARCLVNFN-ILMEDKMNLYPID---VEIIDINDNVPRFLT 135
Query: 679 GAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLIANQQDVTDDIAIAEDGT 737
I + EN+A G F + + GT +++ + ++ + + + +D T
Sbjct: 136 ---EEINVKIMENTAP---GVRFPLSEAGDPDVGTNSLQSYQLSPNRHFSLAVQSGDDET 189
Query: 738 ----IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
+ ++ LDRE+ V+ + + A + G + + + + D ND+ PVF Y+
Sbjct: 190 KYPELVLERVLDREEERVHHLVLTAS-DGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQYQ 248
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYT---LFGEGKEMFDVDENTGVVKFIG 850
+ EN +GT + + A D DEG N Y+ + + +MF ++ TG + +
Sbjct: 249 VTVPENVPVGTRLLT---VHAIDLDEGVNGEVTYSFRKITPKLPKMFHLNSLTGEISTL- 304
Query: 851 DSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKV 902
+ LD E+ Y++ + A+D G ++A+++I + D NDN PE +S +
Sbjct: 305 EGLDYEETAFYEMEVQAQDGPGSLTKAKVLITVLDVNDNAPEVTMTSLSSSI 356
Score = 66.5 bits (155), Expect = 7e-10
Identities = 85/327 (25%), Positives = 144/327 (44%), Gaps = 43/327 (13%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP------------IGPSLTI 130
+ V I D+NDNVP FL +V + E T G + + + P+
Sbjct: 119 IDVEIIDINDNVPRFLTEEINVKIMENTAPGVRFPLSEAGDPDVGTNSLQSYQLSPNRHF 178
Query: 131 PLTVPRG--LTIFKDI---RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR 185
L V G T + ++ R DR++ VH+ +++ +D G S+ + +
Sbjct: 179 SLAVQSGDDETKYPELVLERVLDREEER-----VHHLVLTASDGGDPPRSSTAHIQVTVV 233
Query: 186 KVLDYDA--GDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL--ISGNDR 241
V D+ ++Q+ + + +L +HAID D GV + Y I+
Sbjct: 234 DVNDHTPVFSLPQYQVTV-PENVPVGTRLL---TVHAIDLDEGVNGEVTYSFRKITPKLP 289
Query: 242 KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLND 301
K+F L+S+ G + + LD + + + ++VQA + P +A+V I +LD+ND
Sbjct: 290 KMFHLNSLTGEISTLEGLDYE-----ETAFYEMEVQAQ--DGPGSLTKAKVLITVLDVND 342
Query: 302 NLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDP---KGAFSIDPRS 358
N PE + + SI E+ P G + D+D G+NGE T + + K SID
Sbjct: 343 NAPEVTMTSLSSSIPEDTPLGTVIALFYLQDRDSGKNGEVTCTIPENLPFKLEKSIDNYY 402
Query: 359 GWLTVRNQTVLDREAHSSLRMKVYAKE 385
+T +N LDRE S + + A +
Sbjct: 403 RLVTTKN---LDRETLSLYNITLKATD 426
Score = 64.9 bits (151), Expect = 2e-09
Identities = 92/347 (26%), Positives = 138/347 (39%), Gaps = 32/347 (9%)
Query: 997 RHGHVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
++ +++ R L E E L ++A DGG+ + ++V V DVNDH PVF Y
Sbjct: 190 KYPELVLERVLDREEERVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQYQV 249
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP--FEISPLTGVLSVNGELDR 1110
V E L V A D D G N +TY + LP F ++ LTG +S LD
Sbjct: 250 TVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKITPKLPKMFHLNSLTGEISTLEGLDY 309
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSN 1170
E Y + V A+D DVNDN+P+ L PE L
Sbjct: 310 EETAFYEMEVQAQDG---PGSLTKAKVLITVLDVNDNAPEVTMTS--LSSSIPEDTPLGT 364
Query: 1171 -------HNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQR 1221
+ +S V TI EN P + ++ + T + L LY++ +
Sbjct: 365 VIALFYLQDRDSGKNGEV-TCTIPENLPFKLEKSIDNYYRLVTTKNLDRETLSLYNITLK 423
Query: 1222 KNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSL 1279
G P LS + + VAD D + P F Y + I EN A + LV+
Sbjct: 424 ATDG--GTPPLSRETHIFMQVADTND-----NPPTFPHSSYSVYIAENNPRGASIFLVTA 476
Query: 1280 NLTEHYENFKMRYYILNE--NDTDIRRTFVIDPRNGTLYLVRSPDRE 1324
+ +N ++ Y + + + I+ G LY ++S D E
Sbjct: 477 QDHDSEDNAQITYSLAEDTIQGAPVSSYVSINSDTGVLYALQSFDYE 523
Score = 58.4 bits (135), Expect = 2e-07
Identities = 72/305 (23%), Positives = 120/305 (39%), Gaps = 33/305 (10%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRG 137
+A++ VTV DVND+ P+F Y VTV E P G + + + +T
Sbjct: 225 TAHIQVTVV--DVNDHTPVFSLPQYQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTY--- 279
Query: 138 LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGD--K 195
+F + P P H + ++G L+ + G K
Sbjct: 280 --------SFRKITPKLPKM-FHLNSLTGEISTLEGLDYEETAFYEMEVQAQDGPGSLTK 330
Query: 196 EFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELI----SGNDRKLFSLDSVNG 251
L+ + E+ +I +D +G + + SG + ++ N
Sbjct: 331 AKVLITVLDVNDNAPEVTMTSLSSSIPEDTPLGTVIALFYLQDRDSGKNGEVTCTIPENL 390
Query: 252 SLFLEKELD----LDAEHNLQANTFVLQ---VQASQLNNPLKTAQARVEIELLDLNDNLP 304
LEK +D L NL T L ++A+ P + + + +++ D NDN P
Sbjct: 391 PFKLEKSIDNYYRLVTTKNLDRETLSLYNITLKATDGGTPPLSRETHIFMQVADTNDNPP 450
Query: 305 EFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLT 362
F Y++ I EN P G S+ V A D D +N + TY L D +GA P S +++
Sbjct: 451 TFPHSSYSVYIAENNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGA----PVSSYVS 506
Query: 363 VRNQT 367
+ + T
Sbjct: 507 INSDT 511
Score = 58.0 bits (134), Expect = 2e-07
Identities = 66/247 (26%), Positives = 96/247 (38%), Gaps = 23/247 (9%)
Query: 913 TAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNS 972
T +I V N A +V IPE+ P+GT I D DSG NG++
Sbjct: 329 TKAKVLITVLDVNDNAPEVTMTSLSSSIPEDTPLGTVIALFYLQDRDSGKNGEVTCTIPE 388
Query: 973 EVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN--LNDN 1028
+ P KL + Y+ ++ ++L E S + + + A DGG L+
Sbjct: 389 NL---PFKLEK---SIDNYY-------RLVTTKNLDRETLSLYNITLKATDGGTPPLSRE 435
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-----F 1083
+ + V D ND+ P F + Y+ + E + V A D D NA +TY
Sbjct: 436 THIFMQVADTNDNPPTFPHSSYSVYIAENNPRGASIFLVTAQDHDSEDNAQITYSLAEDT 495
Query: 1084 IQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXD 1143
IQ + I+ TGVL D E + L V A D+G D
Sbjct: 496 IQGAPVSSYVSINSDTGVLYALQSFDYEQLRELQLRVTAHDSG-DPPLSSNMSLSLFVLD 554
Query: 1144 VNDNSPK 1150
NDN P+
Sbjct: 555 QNDNPPE 561
Score = 56.4 bits (130), Expect = 7e-07
Identities = 61/199 (30%), Positives = 89/199 (44%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I EN P G +I + A D DS N QI Y + + V Y IN G
Sbjct: 461 IAENNPRGASIFLVTAQDHDSEDNAQITYSLAED--------TIQGAPVSSYVSINSDTG 512
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK----KTWYN 1051
+ +S E E +L ++A D G+ L+ N+S+ +FV D ND+ P T +
Sbjct: 513 VLYALQSFDYEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPEILYPALPTDGS 572
Query: 1052 FNVEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG-VLSVNGE 1107
+E A + ++ KV A D D GQNA L+Y + + F + TG V +
Sbjct: 573 TGMELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYLLLKASEPGLFAVGLYTGEVRTARAL 632
Query: 1108 LDRETEDKYILTVVARDNG 1126
LDR+ K L V +D+G
Sbjct: 633 LDRDAL-KQSLVVAVQDHG 650
Score = 56.0 bits (129), Expect = 1e-06
Identities = 47/160 (29%), Positives = 70/160 (43%), Gaps = 8/160 (5%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I T + LD E+ Y M V A+ G ++ A +V I + D NDN P +
Sbjct: 299 GEISTLEGLDYEETAFYEMEVQAQDGPGSLTKA---KVLITVLDVNDNAPEVTMTSLSSS 355
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
I E++ +GT I + + D D G N T+ + + +LDR
Sbjct: 356 IPEDTPLGTVIALFYL---QDRDSGKNGEVTCTIPENLPFKLEKSIDNYYRLVTTKNLDR 412
Query: 856 EKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEF 893
E +Y ++L A D G LS E + + + D NDN P F
Sbjct: 413 ETLSLYNITLKATDGGTPPLSRETHIFMQVADTNDNPPTF 452
Score = 50.4 bits (115), Expect = 5e-05
Identities = 38/125 (30%), Positives = 61/125 (48%), Gaps = 5/125 (4%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
+IS +LF+L+ +GSL +D + + A + V + L K +++
Sbjct: 66 IISRGRTQLFALNQRSGSLVTAGRIDRE---EICAQSARCLVNFNILMED-KMNLYPIDV 121
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
E++D+NDN+P F + N+ I+EN G A D D G N +YQL P FS+
Sbjct: 122 EIIDINDNVPRFLTEEINVKIMENTAPGVRFPLSEAGDPDVGTNSLQSYQL-SPNRHFSL 180
Query: 355 DPRSG 359
+SG
Sbjct: 181 AVQSG 185
Score = 47.2 bits (107), Expect = 5e-04
Identities = 76/314 (24%), Positives = 127/314 (40%), Gaps = 32/314 (10%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP--IGPSLTIPLTVPRGLTI 140
V + + DVNDN P T ++ E TP G +F + G + + T+P L
Sbjct: 333 VLITVLDVNDNAPEVTMTSLSSSIPEDTPLGTVIALFYLQDRDSGKNGEVTCTIPENLP- 391
Query: 141 FKDIRAFDR--DKPNTPNSDVH----YSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
FK ++ D T N D Y+I DG S + + +V D +
Sbjct: 392 FKLEKSIDNYYRLVTTKNLDRETLSLYNITLKATDGGTPPLSRETHIFM--QVADTNDNP 449
Query: 195 KEF-----QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLF-SLDS 248
F + I + R L H + + + +L + I G + S++S
Sbjct: 450 PTFPHSSYSVYIAENNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPVSSYVSINS 509
Query: 249 VNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF-- 306
G L+ + D + LQ L+V A +P ++ + + +LD NDN PE
Sbjct: 510 DTGVLYALQSFDYEQLRELQ-----LRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPEILY 564
Query: 307 -EVDFYNISIVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSG 359
+ + +E P G+ V +V+A DKD G+N +Y L G F++ +G
Sbjct: 565 PALPTDGSTGMELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYLLLKASEPGLFAVGLYTG 624
Query: 360 WLTVRNQTVLDREA 373
+ + +LDR+A
Sbjct: 625 EVRTA-RALLDRDA 637
Score = 45.2 bits (102), Expect = 0.002
Identities = 50/171 (29%), Positives = 78/171 (45%), Gaps = 25/171 (14%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN 1287
G P SSTA + VTV DV D PVF Y++ + ENV L++++ + E
Sbjct: 218 GDPPRSSTAHIQVTVVDVNDHT-----PVFSLPQYQVTVPENVPVGTRLLTVHAIDLDEG 272
Query: 1288 FKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHM 1347
+ E R+ I P+ ++ + S E+ T E + E Y E+
Sbjct: 273 ------VNGEVTYSFRK---ITPKLPKMFHLNSLTGEIS-TLEGLDYEETAFYEMEVQ-- 320
Query: 1348 IYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFG 1398
A+D +TK KV++ + DVNDN+P+ T + L ++IP P G
Sbjct: 321 ----AQDGPGSLTK--AKVLITVLDVNDNAPEVTMTS--LSSSIPEDTPLG 363
Score = 37.5 bits (83), Expect = 0.37
Identities = 38/132 (28%), Positives = 59/132 (44%), Gaps = 13/132 (9%)
Query: 436 DEQLMSFVNVEVTLLDANDNNP-VFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPD 488
D L S +++ + +LD NDN P + P S E + +S A+ G ++ KV AVD D
Sbjct: 539 DPPLSSNMSLSLFVLDQNDNPPEILYPALPTDGSTGMELAPRS-AEPGYLVTKVVAVDKD 597
Query: 489 LGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPS 546
GQN + Y L + S + F + TG V A + + + +L V D P
Sbjct: 598 SGQNAWLSYLLLKASEPGL---FAVGLYTGEVRTARALLDRDALKQSLVVAVQDHGQPPL 654
Query: 547 ERRYSLAVVTIE 558
+L V +
Sbjct: 655 SATVTLTVAVAD 666
>AF152334-1|AAD43728.1| 923|Homo sapiens protocadherin gamma B5
protein.
Length = 923
Score = 105 bits (253), Expect = 9e-22
Identities = 121/470 (25%), Positives = 196/470 (41%), Gaps = 39/470 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E ++F +V V + D ND+ P F N +E + +A+ GT A D D+G N +
Sbjct: 111 ENPLNFYHVNVEIEDINDHTPKFT-QNSFELQISESAQPGTRFILEVAEDADIGLNSLQK 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLA 553
Y L + ++ K + + E + + H L + A D P L
Sbjct: 170 YKLSLNPSFSLIIKEKQDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELR 229
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLL 611
I+VT + P P F Y + NV GT+V Q+ D E ++++Y
Sbjct: 230 ---IQVTDAN--DNP--PVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSF- 281
Query: 612 HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVND 671
Y G F++ +SG IT L Y V ++ L +++ D ND
Sbjct: 282 --YRTGQIFSLNSKSGEITTQKKLDFEETKEYSM-VVEGRDGGGLVAQCTVEINIQDEND 338
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
+ HS ++ + EN+ + + + NG N + Q +V I
Sbjct: 339 NSPEVT--FHS-LLEMILENAVPGTLIALIKIHDQDSGENGEVNCQL----QGEVPFKII 391
Query: 732 IAEDGT--IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
+ + + T LDRE+ Y +T+ A ++G + V ++I D NDN PVF
Sbjct: 392 SSSKNSYKLVTDGTLDREQTPEYNVTITAT-DRGKPPLSSSISVILHIRDVNDNAPVFHQ 450
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMF------DVDENT 843
A+Y + EN+ G I + A+D D G N Y++ E + +
Sbjct: 451 ASYLVSVPENNPPGASIAQ---VCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQS 507
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKP 891
GVV F + D E+ ++L+L ARD G LS+ L +++GD NDN P
Sbjct: 508 GVV-FAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAP 556
Score = 89.4 bits (212), Expect = 9e-17
Identities = 84/313 (26%), Positives = 139/313 (44%), Gaps = 23/313 (7%)
Query: 589 GTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYN----RPMYD 644
G+ VG + + F ++ L E F V SG + V L R +P
Sbjct: 44 GSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVSAESGELLVSSRLDREEICGKKPACA 103
Query: 645 FEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTN 704
E A+ EN L+ + V + D+ND + + I S A G F
Sbjct: 104 LEFEAVAENP-LNFY-HVNVEIEDINDHTPKFTQNSFELQI------SESAQPGTRFILE 155
Query: 705 MSSIYGNGTGNV-RFLIANQQDVTDDIAIAEDGTIFTQ----KPLDREKRDVYRMTVIAE 759
++ G ++ ++ ++ + I +DG+ + + K LDRE++ +R+ V+
Sbjct: 156 VAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELALEKTLDREQQSYHRL-VLTA 214
Query: 760 FNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADE 819
+ G +G ++ I + D NDNPPVF Y + EN GT + + ATD DE
Sbjct: 215 LDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQ---VSATDQDE 271
Query: 820 GTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAEL 879
G N+ Y+ + G ++F ++ +G + LD E+ Y + + RD GGL ++ +
Sbjct: 272 GINSEITYSFYRTG-QIFSLNSKSGEIT-TQKKLDFEETKEYSMVVEGRDGGGLVAQCTV 329
Query: 880 IIMIGDENDNKPE 892
I I DENDN PE
Sbjct: 330 EINIQDENDNSPE 342
Score = 82.6 bits (195), Expect = 1e-14
Identities = 108/466 (23%), Positives = 200/466 (42%), Gaps = 44/466 (9%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L + + + DANDN PVF ++Y S++ N GT + +V A D D G N + Y
Sbjct: 222 LSGTTELRIQVTDANDNPPVF-NRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYS 280
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVT 556
RT + F +N +G ++ + E +++ VE D +A T
Sbjct: 281 FYRTGQI-----FSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGG-------LVAQCT 328
Query: 557 IEVT-RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVN--DAFEQNDVSYDLLHG 613
+E+ + N P++ + E + N GT + I+++ D+ E +V+ L
Sbjct: 329 VEINIQDENDNSPEVT--FHSLLEM-ILENAVPGTLIALIKIHDQDSGENGEVNCQL--- 382
Query: 614 YEEGVPFAV--EERSGVITVVD-DLSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVDV 669
+ VPF + ++ V D L R P Y+ A LS + +H+ DV
Sbjct: 383 -QGEVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDV 441
Query: 670 NDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
ND V + ++ ++ + N GA+I Q+ +++ + NG + + ++ + +
Sbjct: 442 NDNAPVFHQASY--LVSVPENNPPGASIAQVCASDL-DLGLNGQVSYSIMASDLEPLALA 498
Query: 730 IAI---AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP- 785
+ A+ G +F Q+ D E+ + +T+ A ++G + + + + + D NDN P
Sbjct: 499 SYVSMSAQSGVVFAQRAFDYEQLRTFELTLQAR-DQGSPALSANVSLRVLVGDRNDNAPR 557
Query: 786 -VFEHATYEGFIMEN--SKIGTEIKMDNIIKATDADEGTNALFMY-TLFGEGKEMFDVDE 841
++ +G + + + + + A DAD G NA Y L +F +
Sbjct: 558 VLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGL 617
Query: 842 NTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
TG V+ DR+ +L + RD G LS+ A L ++ D
Sbjct: 618 RTGEVRTARALGDRD-AARQRLLVAVRDGGQPPLSATATLHLVFAD 662
Score = 81.8 bits (193), Expect = 2e-14
Identities = 53/166 (31%), Positives = 82/166 (49%), Gaps = 3/166 (1%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D+G+ + +Y+L L + +GS + E L+ + Q + L + A
Sbjct: 157 AEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELALEKTLDRE-QQSYHRLVLTAL 215
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
+P + + I++ D NDN P F D Y +S+ EN+P G +VLQV ATD+D+G N
Sbjct: 216 DGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINS 275
Query: 340 EFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
E TY FS++ +SG +T Q LD E M V ++
Sbjct: 276 EITYSFYRTGQIFSLNSKSGEIT--TQKKLDFEETKEYSMVVEGRD 319
Score = 74.9 bits (176), Expect = 2e-12
Identities = 68/239 (28%), Positives = 109/239 (45%), Gaps = 19/239 (7%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
I ++ +N + +V L +I EN GT I + D DSG NG++ + EV P
Sbjct: 331 INIQDENDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEVNCQLQGEV---P 387
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVK 1036
K+ + + Y ++ + + R PE + + I+A D G L+ +ISV + ++
Sbjct: 388 FKIISSSKN--SYKLVTDG----TLDREQTPE--YNVTITATDRGKPPLSSSISVILHIR 439
Query: 1037 DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTD-----L 1091
DVND+ PVF + Y +V E + +V A+D D G N ++Y I SD +
Sbjct: 440 DVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALAS 499
Query: 1092 PFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
+S +GV+ D E + LT+ ARD G D NDN+P+
Sbjct: 500 YVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQG-SPALSANVSLRVLVGDRNDNAPR 557
Score = 73.7 bits (173), Expect = 5e-12
Identities = 61/167 (36%), Positives = 83/167 (49%), Gaps = 12/167 (7%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP-VFEHAT 791
++ G I TQK LD E+ Y M V G+++ V I I+DENDN P V H+
Sbjct: 292 SKSGEITTQKKLDFEETKEYSMVVEGRDGGGLVAQC---TVEINIQDENDNSPEVTFHSL 348
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD 851
E I+EN+ GT I + IK D D G N L GE + + K + D
Sbjct: 349 LE-MILENAVPGTLIAL---IKIHDQDSGENGEVNCQLQGEVPFKI-ISSSKNSYKLVTD 403
Query: 852 -SLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+LDRE+ Y +++ A D G LSS +I+ I D NDN P F+Q
Sbjct: 404 GTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQ 450
Score = 72.5 bits (170), Expect = 1e-11
Identities = 55/169 (32%), Positives = 79/169 (46%), Gaps = 9/169 (5%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
AE G + LDRE+ + EF + Y V + IED ND+ P F ++
Sbjct: 79 AESGELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSF 138
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF---- 848
E I E+++ GT ++ A DAD G N+L Y L + E K+
Sbjct: 139 ELQISESAQPGTRFILE---VAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELA 195
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ 895
+ +LDRE++ ++L L A D G LS EL I + D NDN P FN+
Sbjct: 196 LEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNR 244
Score = 69.7 bits (163), Expect = 7e-11
Identities = 104/418 (24%), Positives = 182/418 (43%), Gaps = 45/418 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I E+ GT I A D D GLN +Y+ + + PS +L +K ++
Sbjct: 142 ISESAQPGTRFILEVAEDADIGLNSLQKYKLS----LNPSF----SLIIKEK-QDGSKYP 192
Query: 1000 HVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+ + ++L E + RL ++ALDGG+ L+ +R+ V D ND+ PVF + Y ++
Sbjct: 193 ELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLR 252
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E + +V ATD D G N+ +TY T F ++ +G ++ +LD E +
Sbjct: 253 ENVPPGTTVLQVSATDQDEGINSEITYSFY--RTGQIFSLNSKSGEITTQKKLDFEETKE 310
Query: 1116 YILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFES 1175
Y + V RD G D NDNSP+ F LLE A +
Sbjct: 311 YSMVVEGRDGG---GLVAQCTVEINIQDENDNSPE-VTFHSLLEMILENAVPGT-----L 361
Query: 1176 VMMIPVYKATIEENAPI-----GTTVAKVFA---NDTDFIGNGNGLILYSLPQRK---NQ 1224
+ +I ++ EN + G K+ + N + +G L P+
Sbjct: 362 IALIKIHDQDSGENGEVNCQLQGEVPFKIISSSKNSYKLVTDGT-LDREQTPEYNVTITA 420
Query: 1225 QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSLNLT 1282
+ G P LSS+ +++ + DV D + PVF Y + + EN A + V +
Sbjct: 421 TDRGKPPLSSSISVILHIRDVND-----NAPVFHQASYLVSVPENNPPGASIAQVCASDL 475
Query: 1283 EHYENFKMRYYIL-NENDTDIRRTFV-IDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
+ N ++ Y I+ ++ + ++V + ++G ++ R+ D E T+E+ ++A Q
Sbjct: 476 DLGLNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQ 533
Score = 68.9 bits (161), Expect = 1e-10
Identities = 70/221 (31%), Positives = 102/221 (46%), Gaps = 21/221 (9%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
I+ ++ N A Q L +PEN P G +I ++ A DLD GLNGQ+ Y I
Sbjct: 435 ILHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYS------IM 488
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRV 1033
S L + L + Y ++ + G V R+ E F L + A D G+ L+ N+S+RV
Sbjct: 489 ASDL--EPLALASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRV 546
Query: 1034 FVKDVNDHFP--VFKKTWYNFN-----VEEAQYTRRVLGKVDATDADFGQNANLTYFI-Q 1085
V D ND+ P ++ + + V A ++ KV A DAD G NA L+Y + Q
Sbjct: 547 LVGDRNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQ 606
Query: 1086 PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
S+ L F + TG + L + L V RD G
Sbjct: 607 ASEPGL-FSLGLRTGEVRTARALGDRDAARQRLLVAVRDGG 646
Score = 64.1 bits (149), Expect = 4e-09
Identities = 68/285 (23%), Positives = 113/285 (39%), Gaps = 15/285 (5%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L + G +S + + + D NDN P+F Y V++ E P G
Sbjct: 212 LTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDE 271
Query: 127 SLTIPLTVP--RGLTIF----KDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKP 180
+ +T R IF K + K + + + +V G D G + + +
Sbjct: 272 GINSEITYSFYRTGQIFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGGLVAQCTVE- 330
Query: 181 VLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND 240
+ ++ D L+ M + ++ IH DQD G + +L
Sbjct: 331 -INIQDENDNSPEVTFHSLLEMILENAVPGTLIALIKIH--DQDSGENGEVNCQLQGEVP 387
Query: 241 RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLN 300
K+ S S S L + LD E + N + + A+ P ++ V + + D+N
Sbjct: 388 FKIIS--SSKNSYKLVTDGTLDREQTPEYN---VTITATDRGKPPLSSSISVILHIRDVN 442
Query: 301 DNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
DN P F Y +S+ EN P G S+ QV A+D D G NG+ +Y +
Sbjct: 443 DNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSI 487
Score = 59.3 bits (137), Expect = 1e-07
Identities = 73/324 (22%), Positives = 133/324 (41%), Gaps = 35/324 (10%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP---------------I 124
+ V V IED+ND+ P F + + + E G + FI +A +
Sbjct: 116 FYHVNVEIEDINDHTPKFTQNSFELQISESAQPGTR-FILEVAEDADIGLNSLQKYKLSL 174
Query: 125 GPSLTIPLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLL 184
PS ++ + + + + ++ A ++ S H +++ D GH L + + + +
Sbjct: 175 NPSFSLIIKEKQDGSKYPEL-ALEKTLDREQQS-YHRLVLTALDGGHPPLSGTTELRIQV 232
Query: 185 RKVLDYD-AGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKL 243
D +++ V + +L + A DQD G+ + + Y ++
Sbjct: 233 TDANDNPPVFNRDVYRVSLRENVPPGTTVL---QVSATDQDEGINSEITYSFYRTG--QI 287
Query: 244 FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNL 303
FSL+S +G + +K+LD + + + + V+ + AQ VEI + D NDN
Sbjct: 288 FSLNSKSGEITTQKKLDFE-----ETKEYSMVVEGRDGGGLV--AQCTVEINIQDENDNS 340
Query: 304 PEFEVDFYNI--SIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWL 361
PE V F+++ I+EN G + + D+D GENGE QL I
Sbjct: 341 PE--VTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEVNCQLQGEVPFKIISSSKNSY 398
Query: 362 TVRNQTVLDREAHSSLRMKVYAKE 385
+ LDRE + + A +
Sbjct: 399 KLVTDGTLDREQTPEYNVTITATD 422
Score = 49.2 bits (112), Expect = 1e-04
Identities = 62/240 (25%), Positives = 103/240 (42%), Gaps = 29/240 (12%)
Query: 150 DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIH 209
D+ TP +V ++ D G L SS +L +R V D Q + S +
Sbjct: 407 DREQTPEYNV---TITATDRGKPPLSSSISVILHIRDV--NDNAPVFHQASYLVSVPENN 461
Query: 210 KEILFPEPIHAIDQDLGVGATLRYELISGNDRKL-----FSLDSVNGSLFLEKELDLDAE 264
+ A D DLG+ + Y +++ + L S+ + +G +F ++ D +
Sbjct: 462 PPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYE-- 519
Query: 265 HNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLPN 321
Q TF L +QA +P +A + + + D NDN P + ++ + +P
Sbjct: 520 ---QLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPR 576
Query: 322 ----GFSVLQVMATDKDQGENGEFTY---QLDDPKGAFSIDPRSGWLTVRNQTVL-DREA 373
G+ V +V+A D D G N +Y Q +P G FS+ R+G VR L DR+A
Sbjct: 577 AAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEP-GLFSLGLRTG--EVRTARALGDRDA 633
Score = 46.0 bits (104), Expect = 0.001
Identities = 63/225 (28%), Positives = 94/225 (41%), Gaps = 28/225 (12%)
Query: 938 FLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINER 997
+ IPE +P G+ + L A DL G + Q +P KL + K YF ++
Sbjct: 35 YRIPEEMPKGSVVGNL-ATDL--GFSVQ---------ELPTRKLRVSS--EKPYFTVSAE 80
Query: 998 HGHVIVARSLPPES------EFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYN 1051
G ++V+ L E L A+ LN V V ++D+NDH P F + +
Sbjct: 81 SGELLVSSRLDREEICGKKPACALEFEAVAENPLNF-YHVNVEIEDINDHTPKFTQNSFE 139
Query: 1052 FNV-EEAQYTRRVLGKVDATDADFGQNANLTY--FIQPSDTDLPFEISPLTGV--LSVNG 1106
+ E AQ R + +V A DAD G N+ Y + PS + + E + L++
Sbjct: 140 LQISESAQPGTRFILEV-AEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELALEK 198
Query: 1107 ELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
LDRE + + L + A D G D NDN P F
Sbjct: 199 TLDREQQSYHRLVLTALDGG-HPPLSGTTELRIQVTDANDNPPVF 242
Score = 45.2 bits (102), Expect = 0.002
Identities = 43/160 (26%), Positives = 76/160 (47%), Gaps = 9/160 (5%)
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
+++ F++ + +G L + LD + E + L+ +A NPL VEIE D
Sbjct: 70 SEKPYFTVSAESGELLVSSRLDRE-EICGKKPACALEFEAVA-ENPLNFYHVNVEIE--D 125
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD-DPKGAFSIDPR 357
+ND+ P+F + + + I E+ G + +A D D G N Y+L +P + I +
Sbjct: 126 INDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEK 185
Query: 358 ---SGWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
S + + + LDRE S R+ + A + +P + GT
Sbjct: 186 QDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGT 225
>AF152327-1|AAD43721.1| 932|Homo sapiens protocadherin gamma A7
protein.
Length = 932
Score = 105 bits (253), Expect = 9e-22
Identities = 117/478 (24%), Positives = 193/478 (40%), Gaps = 37/478 (7%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
N E M+ ++V ++D NDN P F+ + + N G +A DPD+G
Sbjct: 105 NFNILMEDKMNLYPIDVEIIDINDNVPRFLTEEI-NVKIMENTAPGVRFPLSEAGDPDVG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSE 547
N + Y L + ++ + V E + E H L + ASD P
Sbjct: 164 TNSLQSYQLSPNRHFSLAVQSGDDETKYPELVLERVLDREEERVHHLVLTASDGGDPPRS 223
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVS 607
+ V ++V T P F Y+ V NV +GT + + D E V+
Sbjct: 224 STAHIQVTVVDVNDHT-------PVFSLPQYQVTVPENVPVGTRLLTVHAIDLDE--GVN 274
Query: 608 YDLLHGYEEGVP-----FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNA 662
++ + + + P F + +G I+ ++ L Y+ E A Q+
Sbjct: 275 GEVTYSFRKITPKLPKMFHLNSLTGEISTLEGLDYEETAFYEMEVQA-QDGPGSLTKAKV 333
Query: 663 TVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIAN 722
+ V+DVND + + S I ++ G I + + S G V I
Sbjct: 334 LITVLDVNDNAPEVTMTSLSSSI--PEDTPLGTVIALFYLQDRDS---GKNGEVTCTIPE 388
Query: 723 QQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEND 782
+ +I + T K LDRE +Y +T+ A + G + + + + D ND
Sbjct: 389 NLPFKLEKSIDNYYRLVTTKNLDRETLSLYNITLKAT-DGGTPPLSRETHIFMQVADTND 447
Query: 783 NPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEM 836
NPP F H++Y +I EN+ G I ++ A D D NA Y+L +
Sbjct: 448 NPPTFPHSSYSVYIAENNPRGASI---FLVTAQDHDSEDNAQITYSLAEDTIQGAPVSSY 504
Query: 837 FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
++ +TGV+ + S D E+ +L + A D+G LSS L + + D+NDN PE
Sbjct: 505 VSINSDTGVL-YALQSFDYEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPE 561
Score = 78.6 bits (185), Expect = 2e-13
Identities = 61/217 (28%), Positives = 93/217 (42%), Gaps = 20/217 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN+P+GT ++ ++A+DLD G+NG++ Y F I P ++ + F +N G
Sbjct: 251 VPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRK---ITP--------KLPKMFHLNSLTG 299
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ L E + + + A DG V + V DVND+ P T + ++ E
Sbjct: 300 EISTLEGLDYEETAFYEMEVQAQDGPGSLTKAKVLITVLDVNDNAPEVTMTSLSSSIPED 359
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
V+ D D G+N +T I +LPF++ L LDRET
Sbjct: 360 TPLGTVIALFYLQDRDSGKNGEVTCTI---PENLPFKLEKSIDNYYRLVTTKNLDRETLS 416
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
Y +T+ A D G D NDN P F
Sbjct: 417 LYNITLKATDGG-TPPLSRETHIFMQVADTNDNPPTF 452
Score = 75.4 bits (177), Expect = 1e-12
Identities = 81/352 (23%), Positives = 157/352 (44%), Gaps = 38/352 (10%)
Query: 574 MGAPYEFWVG-------SNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVP--FAVEE 624
+G P+E W G G+ VG I + E +++ + G FA+ +
Sbjct: 20 LGTPWEAWAGRILYSVSEETDKGSFVGDIAKDLGLEPRELAERGVRIISRGRTQLFALNQ 79
Query: 625 RSGVITVVDDLSRYN------RPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLK 678
RSG + + R R + +F + +++ NL + V ++D+ND L
Sbjct: 80 RSGSLVTAGRIDREEICAQSARCLVNFN-ILMEDKMNLYPID---VEIIDINDNVPRFLT 135
Query: 679 GAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLIANQQDVTDDIAIAEDGT 737
I + EN+A G F + + GT +++ + ++ + + + +D T
Sbjct: 136 ---EEINVKIMENTAP---GVRFPLSEAGDPDVGTNSLQSYQLSPNRHFSLAVQSGDDET 189
Query: 738 ----IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
+ ++ LDRE+ V+ + + A + G + + + + D ND+ PVF Y+
Sbjct: 190 KYPELVLERVLDREEERVHHLVLTAS-DGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQYQ 248
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYT---LFGEGKEMFDVDENTGVVKFIG 850
+ EN +GT + + A D DEG N Y+ + + +MF ++ TG + +
Sbjct: 249 VTVPENVPVGTRLLT---VHAIDLDEGVNGEVTYSFRKITPKLPKMFHLNSLTGEISTL- 304
Query: 851 DSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKV 902
+ LD E+ Y++ + A+D G ++A+++I + D NDN PE +S +
Sbjct: 305 EGLDYEETAFYEMEVQAQDGPGSLTKAKVLITVLDVNDNAPEVTMTSLSSSI 356
Score = 66.5 bits (155), Expect = 7e-10
Identities = 85/327 (25%), Positives = 144/327 (44%), Gaps = 43/327 (13%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP------------IGPSLTI 130
+ V I D+NDNVP FL +V + E T G + + + P+
Sbjct: 119 IDVEIIDINDNVPRFLTEEINVKIMENTAPGVRFPLSEAGDPDVGTNSLQSYQLSPNRHF 178
Query: 131 PLTVPRG--LTIFKDI---RAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR 185
L V G T + ++ R DR++ VH+ +++ +D G S+ + +
Sbjct: 179 SLAVQSGDDETKYPELVLERVLDREEER-----VHHLVLTASDGGDPPRSSTAHIQVTVV 233
Query: 186 KVLDYDA--GDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL--ISGNDR 241
V D+ ++Q+ + + +L +HAID D GV + Y I+
Sbjct: 234 DVNDHTPVFSLPQYQVTV-PENVPVGTRLL---TVHAIDLDEGVNGEVTYSFRKITPKLP 289
Query: 242 KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLND 301
K+F L+S+ G + + LD + + + ++VQA + P +A+V I +LD+ND
Sbjct: 290 KMFHLNSLTGEISTLEGLDYE-----ETAFYEMEVQAQ--DGPGSLTKAKVLITVLDVND 342
Query: 302 NLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDP---KGAFSIDPRS 358
N PE + + SI E+ P G + D+D G+NGE T + + K SID
Sbjct: 343 NAPEVTMTSLSSSIPEDTPLGTVIALFYLQDRDSGKNGEVTCTIPENLPFKLEKSIDNYY 402
Query: 359 GWLTVRNQTVLDREAHSSLRMKVYAKE 385
+T +N LDRE S + + A +
Sbjct: 403 RLVTTKN---LDRETLSLYNITLKATD 426
Score = 64.9 bits (151), Expect = 2e-09
Identities = 92/347 (26%), Positives = 138/347 (39%), Gaps = 32/347 (9%)
Query: 997 RHGHVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
++ +++ R L E E L ++A DGG+ + ++V V DVNDH PVF Y
Sbjct: 190 KYPELVLERVLDREEERVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQYQV 249
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP--FEISPLTGVLSVNGELDR 1110
V E L V A D D G N +TY + LP F ++ LTG +S LD
Sbjct: 250 TVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKITPKLPKMFHLNSLTGEISTLEGLDY 309
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSN 1170
E Y + V A+D DVNDN+P+ L PE L
Sbjct: 310 EETAFYEMEVQAQDG---PGSLTKAKVLITVLDVNDNAPEVTMTS--LSSSIPEDTPLGT 364
Query: 1171 -------HNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQR 1221
+ +S V TI EN P + ++ + T + L LY++ +
Sbjct: 365 VIALFYLQDRDSGKNGEV-TCTIPENLPFKLEKSIDNYYRLVTTKNLDRETLSLYNITLK 423
Query: 1222 KNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSL 1279
G P LS + + VAD D + P F Y + I EN A + LV+
Sbjct: 424 ATDG--GTPPLSRETHIFMQVADTND-----NPPTFPHSSYSVYIAENNPRGASIFLVTA 476
Query: 1280 NLTEHYENFKMRYYILNE--NDTDIRRTFVIDPRNGTLYLVRSPDRE 1324
+ +N ++ Y + + + I+ G LY ++S D E
Sbjct: 477 QDHDSEDNAQITYSLAEDTIQGAPVSSYVSINSDTGVLYALQSFDYE 523
Score = 58.4 bits (135), Expect = 2e-07
Identities = 72/305 (23%), Positives = 120/305 (39%), Gaps = 33/305 (10%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRG 137
+A++ VTV DVND+ P+F Y VTV E P G + + + +T
Sbjct: 225 TAHIQVTVV--DVNDHTPVFSLPQYQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTY--- 279
Query: 138 LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGD--K 195
+F + P P H + ++G L+ + G K
Sbjct: 280 --------SFRKITPKLPKM-FHLNSLTGEISTLEGLDYEETAFYEMEVQAQDGPGSLTK 330
Query: 196 EFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELI----SGNDRKLFSLDSVNG 251
L+ + E+ +I +D +G + + SG + ++ N
Sbjct: 331 AKVLITVLDVNDNAPEVTMTSLSSSIPEDTPLGTVIALFYLQDRDSGKNGEVTCTIPENL 390
Query: 252 SLFLEKELD----LDAEHNLQANTFVLQ---VQASQLNNPLKTAQARVEIELLDLNDNLP 304
LEK +D L NL T L ++A+ P + + + +++ D NDN P
Sbjct: 391 PFKLEKSIDNYYRLVTTKNLDRETLSLYNITLKATDGGTPPLSRETHIFMQVADTNDNPP 450
Query: 305 EFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLT 362
F Y++ I EN P G S+ V A D D +N + TY L D +GA P S +++
Sbjct: 451 TFPHSSYSVYIAENNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGA----PVSSYVS 506
Query: 363 VRNQT 367
+ + T
Sbjct: 507 INSDT 511
Score = 58.0 bits (134), Expect = 2e-07
Identities = 66/247 (26%), Positives = 96/247 (38%), Gaps = 23/247 (9%)
Query: 913 TAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNS 972
T +I V N A +V IPE+ P+GT I D DSG NG++
Sbjct: 329 TKAKVLITVLDVNDNAPEVTMTSLSSSIPEDTPLGTVIALFYLQDRDSGKNGEVTCTIPE 388
Query: 973 EVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN--LNDN 1028
+ P KL + Y+ ++ ++L E S + + + A DGG L+
Sbjct: 389 NL---PFKLEK---SIDNYY-------RLVTTKNLDRETLSLYNITLKATDGGTPPLSRE 435
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-----F 1083
+ + V D ND+ P F + Y+ + E + V A D D NA +TY
Sbjct: 436 THIFMQVADTNDNPPTFPHSSYSVYIAENNPRGASIFLVTAQDHDSEDNAQITYSLAEDT 495
Query: 1084 IQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXD 1143
IQ + I+ TGVL D E + L V A D+G D
Sbjct: 496 IQGAPVSSYVSINSDTGVLYALQSFDYEQLRELQLRVTAHDSG-DPPLSSNMSLSLFVLD 554
Query: 1144 VNDNSPK 1150
NDN P+
Sbjct: 555 QNDNPPE 561
Score = 56.4 bits (130), Expect = 7e-07
Identities = 61/199 (30%), Positives = 89/199 (44%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I EN P G +I + A D DS N QI Y + + V Y IN G
Sbjct: 461 IAENNPRGASIFLVTAQDHDSEDNAQITYSLAED--------TIQGAPVSSYVSINSDTG 512
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK----KTWYN 1051
+ +S E E +L ++A D G+ L+ N+S+ +FV D ND+ P T +
Sbjct: 513 VLYALQSFDYEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPEILYPALPTDGS 572
Query: 1052 FNVEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG-VLSVNGE 1107
+E A + ++ KV A D D GQNA L+Y + + F + TG V +
Sbjct: 573 TGMELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYLLLKASEPGLFAVGLYTGEVRTARAL 632
Query: 1108 LDRETEDKYILTVVARDNG 1126
LDR+ K L V +D+G
Sbjct: 633 LDRDAL-KQSLVVAVQDHG 650
Score = 56.0 bits (129), Expect = 1e-06
Identities = 47/160 (29%), Positives = 70/160 (43%), Gaps = 8/160 (5%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I T + LD E+ Y M V A+ G ++ A +V I + D NDN P +
Sbjct: 299 GEISTLEGLDYEETAFYEMEVQAQDGPGSLTKA---KVLITVLDVNDNAPEVTMTSLSSS 355
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
I E++ +GT I + + D D G N T+ + + +LDR
Sbjct: 356 IPEDTPLGTVIALFYL---QDRDSGKNGEVTCTIPENLPFKLEKSIDNYYRLVTTKNLDR 412
Query: 856 EKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEF 893
E +Y ++L A D G LS E + + + D NDN P F
Sbjct: 413 ETLSLYNITLKATDGGTPPLSRETHIFMQVADTNDNPPTF 452
Score = 50.4 bits (115), Expect = 5e-05
Identities = 38/125 (30%), Positives = 61/125 (48%), Gaps = 5/125 (4%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
+IS +LF+L+ +GSL +D + + A + V + L K +++
Sbjct: 66 IISRGRTQLFALNQRSGSLVTAGRIDRE---EICAQSARCLVNFNILMED-KMNLYPIDV 121
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
E++D+NDN+P F + N+ I+EN G A D D G N +YQL P FS+
Sbjct: 122 EIIDINDNVPRFLTEEINVKIMENTAPGVRFPLSEAGDPDVGTNSLQSYQL-SPNRHFSL 180
Query: 355 DPRSG 359
+SG
Sbjct: 181 AVQSG 185
Score = 47.2 bits (107), Expect = 5e-04
Identities = 76/314 (24%), Positives = 127/314 (40%), Gaps = 32/314 (10%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP--IGPSLTIPLTVPRGLTI 140
V + + DVNDN P T ++ E TP G +F + G + + T+P L
Sbjct: 333 VLITVLDVNDNAPEVTMTSLSSSIPEDTPLGTVIALFYLQDRDSGKNGEVTCTIPENLP- 391
Query: 141 FKDIRAFDR--DKPNTPNSDVH----YSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
FK ++ D T N D Y+I DG S + + +V D +
Sbjct: 392 FKLEKSIDNYYRLVTTKNLDRETLSLYNITLKATDGGTPPLSRETHIFM--QVADTNDNP 449
Query: 195 KEF-----QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLF-SLDS 248
F + I + R L H + + + +L + I G + S++S
Sbjct: 450 PTFPHSSYSVYIAENNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPVSSYVSINS 509
Query: 249 VNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF-- 306
G L+ + D + LQ L+V A +P ++ + + +LD NDN PE
Sbjct: 510 DTGVLYALQSFDYEQLRELQ-----LRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPEILY 564
Query: 307 -EVDFYNISIVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSG 359
+ + +E P G+ V +V+A DKD G+N +Y L G F++ +G
Sbjct: 565 PALPTDGSTGMELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYLLLKASEPGLFAVGLYTG 624
Query: 360 WLTVRNQTVLDREA 373
+ + +LDR+A
Sbjct: 625 EVRTA-RALLDRDA 637
Score = 45.2 bits (102), Expect = 0.002
Identities = 50/171 (29%), Positives = 78/171 (45%), Gaps = 25/171 (14%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN 1287
G P SSTA + VTV DV D PVF Y++ + ENV L++++ + E
Sbjct: 218 GDPPRSSTAHIQVTVVDVNDHT-----PVFSLPQYQVTVPENVPVGTRLLTVHAIDLDEG 272
Query: 1288 FKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHM 1347
+ E R+ I P+ ++ + S E+ T E + E Y E+
Sbjct: 273 ------VNGEVTYSFRK---ITPKLPKMFHLNSLTGEIS-TLEGLDYEETAFYEMEVQ-- 320
Query: 1348 IYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFG 1398
A+D +TK KV++ + DVNDN+P+ T + L ++IP P G
Sbjct: 321 ----AQDGPGSLTK--AKVLITVLDVNDNAPEVTMTS--LSSSIPEDTPLG 363
Score = 37.5 bits (83), Expect = 0.37
Identities = 38/132 (28%), Positives = 59/132 (44%), Gaps = 13/132 (9%)
Query: 436 DEQLMSFVNVEVTLLDANDNNP-VFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPD 488
D L S +++ + +LD NDN P + P S E + +S A+ G ++ KV AVD D
Sbjct: 539 DPPLSSNMSLSLFVLDQNDNPPEILYPALPTDGSTGMELAPRS-AEPGYLVTKVVAVDKD 597
Query: 489 LGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPS 546
GQN + Y L + S + F + TG V A + + + +L V D P
Sbjct: 598 SGQNAWLSYLLLKASEPGL---FAVGLYTGEVRTARALLDRDALKQSLVVAVQDHGQPPL 654
Query: 547 ERRYSLAVVTIE 558
+L V +
Sbjct: 655 SATVTLTVAVAD 666
>BC101049-1|AAI01050.1| 801|Homo sapiens cadherin 20, type 2 protein.
Length = 801
Score = 105 bits (251), Expect = 2e-21
Identities = 121/487 (24%), Positives = 196/487 (40%), Gaps = 45/487 (9%)
Query: 686 FHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLD 745
F V E G ++ + S G G+++++++ + G I + LD
Sbjct: 66 FFVLEEYTGT--DPLYVGKLHSDMDRGDGSIKYILSGEGAGIVFTIDDTTGDIHAIQRLD 123
Query: 746 REKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTE 805
RE+R Y + A + + I I+D NDN P F Y + E S +GT
Sbjct: 124 REERAQYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKFLDGPYVATVPEMSPVGTS 183
Query: 806 IKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSL 865
+ A D G +A +Y++ +G+ F VD TGV++ ++DRE K Y++ +
Sbjct: 184 VIQVTATDADDPTYGNSARVVYSIL-QGQPYFSVDSKTGVIRTALMNMDREAKEYYEVII 242
Query: 866 VARD----TGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
A+D GGL+ + I + D NDN P F Q ++ ++ + ++ T G
Sbjct: 243 QAKDMGGQLGGLAGTTTVNITLSDVNDNPPRFPQ--KHYQMSVLESAPISSTVG------ 294
Query: 922 KPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
FA D+D E I +K +D D I + N +V I
Sbjct: 295 ---RVFAKDLD---------EGI---NAEMKYTIVDGDGADAFDISTDPNFQVGI----- 334
Query: 982 SADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDH 1041
+ VK+ + + + P E R L+ G D +V + V+DV D
Sbjct: 335 ----ITVKKPLSFESKKSYTLKVEGANPHLEMRF----LNLGPFQDTTTVHISVEDV-DE 385
Query: 1042 FPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGV 1101
PVF+ +Y V E + + A D D N+ + SD F + TG
Sbjct: 386 PPVFEPGFYFVEVPEDVAIGTTIQIISAKDPDVTNNSIRYSIDRSSDPGRFFYVDITTGA 445
Query: 1102 LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWK 1161
L LDRE + +TV+A + DVNDN+P+F F E +
Sbjct: 446 LMTARPLDREEFSWHNITVLAMEMN-NPSQVGSVPVTIKVLDVNDNAPEFPRFYEAFVCE 504
Query: 1162 HPEADEL 1168
+ +A +L
Sbjct: 505 NAKAGQL 511
Score = 82.6 bits (195), Expect = 1e-14
Identities = 114/469 (24%), Positives = 195/469 (41%), Gaps = 47/469 (10%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVD---PDLGQNGMVLYDLQRTS 503
+ + D NDN P F+ Y ++ + VGT + +V A D P G + V+Y + +
Sbjct: 153 IKIQDINDNEPKFLDGP-YVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQGQ 211
Query: 504 NLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLA-VVTIEVTRG 562
F ++ TG + A ++ + E Q + + LA T+ +T
Sbjct: 212 PY-----FSVDSKTGVIRTALMN-MDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLS 265
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGY-EEGVP 619
+ P P F Y+ V + I ++VG++ D E ++ Y ++ G +
Sbjct: 266 DVNDNP--PRFPQKHYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFD 323
Query: 620 FAVEE--RSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT------NATVHV-VDVN 670
+ + + G+ITV LS ++ Y + + + + TVH+ V+
Sbjct: 324 ISTDPNFQVGIITVKKPLSFESKKSYTLKVEGANPHLEMRFLNLGPFQDTTTVHISVEDV 383
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
DE V G + V E+ A QI + N ++R+ I D
Sbjct: 384 DEPPVFEPGFY---FVEVPEDVAIGTTIQIISAKDPDVTNN---SIRYSIDRSSDPGRFF 437
Query: 731 AI-AEDGTIFTQKPLDREKRDVYRMTVIA-EFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ G + T +PLDRE+ + +TV+A E N S G VTI + D NDN P F
Sbjct: 438 YVDITTGALMTARPLDREEFSWHNITVLAMEMNNP--SQVGSVPVTIKVLDVNDNAPEFP 495
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNAL-FMYTLFGEGKE-----MFDVDEN 842
YE F+ EN+K G I+ + A D D+ N F Y+L E + D +N
Sbjct: 496 RF-YEAFVCENAKAGQLIQ---TVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDNQDN 551
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDN 889
T + ++++ ++ L ++ D+G LSS L I + +D+
Sbjct: 552 TARILTRRSGFRQQEQSVFHLPILIADSGQPVLSSTGTLTIQVCSCDDD 600
Score = 71.7 bits (168), Expect = 2e-11
Identities = 90/348 (25%), Positives = 152/348 (43%), Gaps = 31/348 (8%)
Query: 571 PDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQN-DVSYDLLHGYEEGVP-FAVEERSGV 628
P F+ PY V +GTSV Q+ DA + S +++ +G P F+V+ ++GV
Sbjct: 163 PKFLDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQGQPYFSVDSKTGV 222
Query: 629 I-TVVDDLSRYNRPMYDFEAVALQENANLS-IVTNATVHVV--DVNDERGVLLKGAHSPI 684
I T + ++ R + Y+ A L + TV++ DVND + +
Sbjct: 223 IRTALMNMDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVNDNPPRFPQKHYQMS 282
Query: 685 IFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED-----GTIF 739
+ ++ + +G++F ++ +++ I + D D I+ D G I
Sbjct: 283 V--LESAPISSTVGRVFAKDLDE---GINAEMKYTIVDG-DGADAFDISTDPNFQVGIIT 336
Query: 740 TQKPLDREKRDVYRMTVIAEFNKGV---ISGAGIYQ--VTIYIEDEN-DNPPVFEHATYE 793
+KPL E + Y + V N + G +Q T++I E+ D PPVFE Y
Sbjct: 337 VKKPLSFESKKSYTLKVEGA-NPHLEMRFLNLGPFQDTTTVHISVEDVDEPPVFEPGFYF 395
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNAL-FMYTLFGEGKEMFDVDENTGVVKFIGDS 852
+ E+ IGT I+ II A D D N++ + + F VD TG +
Sbjct: 396 VEVPEDVAIGTTIQ---IISAKDPDVTNNSIRYSIDRSSDPGRFFYVDITTGAL-MTARP 451
Query: 853 LDREKKIMYKLSLVARDTGGLS--SEAELIIMIGDENDNKPEFNQIEE 898
LDRE+ + ++++A + S + I + D NDN PEF + E
Sbjct: 452 LDREEFSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAPEFPRFYE 499
Score = 61.7 bits (143), Expect = 2e-08
Identities = 84/359 (23%), Positives = 144/359 (40%), Gaps = 28/359 (7%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L V +TL D NDN P F P Y+ S+ +A + + +G+V A D D G N + Y
Sbjct: 254 LAGTTTVNITLSDVNDNPPRF-PQKHYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYT 312
Query: 499 LQRTSNLTITSPFKINPN--TGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVT 556
+ +PN G ++V + E + + ++ + ANP L +
Sbjct: 313 IVDGDGAD-AFDISTDPNFQVGIITVKKPLSFESKKSYTLKV--EGANPHLEMRFLNLGP 369
Query: 557 IEVTRGTKGNKPDI---PDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQNDVSYDLLH 612
+ T + D+ P F Y V +V IGT++ I D N + Y +
Sbjct: 370 FQDTTTVHISVEDVDEPPVFEPGFYFVEVPEDVAIGTTIQIISAKDPDVTNNSIRYSIDR 429
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTN--ATVHVVDVN 670
+ G F V+ +G + L R ++ +A++ N N S V + T+ V+DVN
Sbjct: 430 SSDPGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMN-NPSQVGSVPVTIKVLDVN 488
Query: 671 DERGVLLKGAHSPIIFHVKEN---SAGAAIGQIFHTNMSSIY----GNGTGNVRFLIANQ 723
D + + + + K +A+ Q N Y N F I +
Sbjct: 489 DNAPEFPRFYEAFVCENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDN 548
Query: 724 QDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTV-IAEFNKGVISGAGIYQVTIYIEDEN 781
QD T I G F Q +++ V+ + + IA+ + V+S G + + D++
Sbjct: 549 QDNTARILTRRSG--FRQ-----QEQSVFHLPILIADSGQPVLSSTGTLTIQVCSCDDD 600
Score = 61.7 bits (143), Expect = 2e-08
Identities = 42/135 (31%), Positives = 66/135 (48%), Gaps = 8/135 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR-KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
I A D D+ ++RY + +D + F +D G+L + LD + + + + V
Sbjct: 411 ISAKDPDV-TNNSIRYSIDRSSDPGRFFYVDITTGALMTARPLDRE-----EFSWHNITV 464
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A ++NNP + V I++LD+NDN PEF FY + EN G + V A D+D
Sbjct: 465 LAMEMNNPSQVGSVPVTIKVLDVNDNAPEFP-RFYEAFVCENAKAGQLIQTVSAVDQDDP 523
Query: 337 ENGEFTYQLDDPKGA 351
NG+ Y P+ A
Sbjct: 524 RNGQHFYYSLAPEAA 538
Score = 59.7 bits (138), Expect = 8e-08
Identities = 50/185 (27%), Positives = 89/185 (48%), Gaps = 14/185 (7%)
Query: 213 LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLD--AEHNLQAN 270
L+ +H+ D D G G+ ++Y L +F++D G + + LD + A++ L+A
Sbjct: 78 LYVGKLHS-DMDRGDGS-IKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRA- 134
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
Q + P++ ++ I++ D+NDN P+F Y ++ E P G SV+QV A
Sbjct: 135 ----QALDRRTGRPMEP-ESEFIIKIQDINDNEPKFLDGPYVATVPEMSPVGTSVIQVTA 189
Query: 331 TDKDQ---GENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETN 387
TD D G + Y + + FS+D ++G + +DREA + + AK+
Sbjct: 190 TDADDPTYGNSARVVYSILQGQPYFSVDSKTGVIRTALMN-MDREAKEYYEVIIQAKDMG 248
Query: 388 PSVVG 392
+ G
Sbjct: 249 GQLGG 253
Score = 58.0 bits (134), Expect = 2e-07
Identities = 52/170 (30%), Positives = 79/170 (46%), Gaps = 16/170 (9%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D G A + Y ++ G + FS+DS G + +++D E + + +QA
Sbjct: 192 ADDPTYGNSARVVYSILQG--QPYFSVDSKTG-VIRTALMNMDREAK---EYYEVIIQAK 245
Query: 280 QLNNPLK--TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
+ L V I L D+NDN P F Y +S++E+ P +V +V A D D+G
Sbjct: 246 DMGGQLGGLAGTTTVNITLSDVNDNPPRFPQKHYQMSVLESAPISSTVGRVFAKDLDEGI 305
Query: 338 NGEFTYQLDDPKGA----FSIDP--RSGWLTVRNQTVLDREAHSSLRMKV 381
N E Y + D GA S DP + G +TV+ L E+ S +KV
Sbjct: 306 NAEMKYTIVDGDGADAFDISTDPNFQVGIITVKKP--LSFESKKSYTLKV 353
Score = 50.8 bits (116), Expect = 4e-05
Identities = 50/186 (26%), Positives = 83/186 (44%), Gaps = 14/186 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVN----GSLFLEKELDLDAE--HNLQANT 271
+ A D D G+ A ++Y ++ G+ F + + G + ++K L +++ + L+
Sbjct: 296 VFAKDLDEGINAEMKYTIVDGDGADAFDISTDPNFQVGIITVKKPLSFESKKSYTLKVEG 355
Query: 272 FVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMAT 331
++ LN V I + D+ D P FE FY + + E++ G ++ + A
Sbjct: 356 ANPHLEMRFLNLGPFQDTTTVHISVEDV-DEPPVFEPGFYFVEVPEDVAIGTTIQIISAK 414
Query: 332 DKDQGENGEFTYQLD---DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE-TN 387
D D N Y +D DP F +D +G L LDRE S + V A E N
Sbjct: 415 DPDV-TNNSIRYSIDRSSDPGRFFYVDITTGALMTARP--LDREEFSWHNITVLAMEMNN 471
Query: 388 PSVVGT 393
PS VG+
Sbjct: 472 PSQVGS 477
Score = 48.0 bits (109), Expect = 3e-04
Identities = 35/127 (27%), Positives = 58/127 (45%), Gaps = 20/127 (15%)
Query: 1293 YILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVA 1352
YIL+ I F ID G ++ ++ DRE + Y + +A ++ R + P +
Sbjct: 96 YILSGEGAGI--VFTIDDTTGDIHAIQRLDREERAQYTLRAQALDRRTGRPME----PES 149
Query: 1353 EDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQLKGAIGHHP 1412
E +++I+D+NDN PKF +G P V +P +P G V+Q+ P
Sbjct: 150 E------------FIIKIQDINDNEPKFLDG--PYVATVPEMSPVGTSVIQVTATDADDP 195
Query: 1413 TASRTVR 1419
T + R
Sbjct: 196 TYGNSAR 202
Score = 46.4 bits (105), Expect = 8e-04
Identities = 45/148 (30%), Positives = 72/148 (48%), Gaps = 18/148 (12%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PE++ IGTTI ++A D D N IRY + S+D R+F ++ G
Sbjct: 398 VPEDVAIGTTIQIISAKDPDV-TNNSIRYSIDR---------SSDP---GRFFYVDITTG 444
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVK--DVNDHFPVFKKTWYNFNVE 1055
++ AR L E S + + A++ N + SV V +K DVND+ P F + + F E
Sbjct: 445 ALMTARPLDREEFSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAPEFPRFYEAFVCE 504
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYF 1083
A+ +++ V A D D +N Y+
Sbjct: 505 NAK-AGQLIQTVSAVDQDDPRNGQHFYY 531
Score = 40.3 bits (90), Expect = 0.052
Identities = 16/29 (55%), Positives = 21/29 (72%)
Query: 85 VYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
+ I+D+NDN P FLD PY TV E++P G
Sbjct: 153 IKIQDINDNEPKFLDGPYVATVPEMSPVG 181
Score = 38.7 bits (86), Expect = 0.16
Identities = 31/106 (29%), Positives = 43/106 (40%), Gaps = 6/106 (5%)
Query: 1049 WYNFNVEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVN 1105
W F V E +YT +GK+ + D D G + ++ Y + + F I TG +
Sbjct: 63 WNQFFVLE-EYTGTDPLYVGKLHS-DMDRG-DGSIKYILSGEGAGIVFTIDDTTGDIHAI 119
Query: 1106 GELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
LDRE +Y L A D D+NDN PKF
Sbjct: 120 QRLDREERAQYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKF 165
Score = 33.5 bits (73), Expect = 6.0
Identities = 17/40 (42%), Positives = 25/40 (62%), Gaps = 1/40 (2%)
Query: 1182 YKATIEENAPIGTTVAKVFANDTDFIGNGNGL-ILYSLPQ 1220
Y AT+ E +P+GT+V +V A D D GN ++YS+ Q
Sbjct: 170 YVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQ 209
>BC101048-1|AAI01049.1| 801|Homo sapiens cadherin 20, type 2 protein.
Length = 801
Score = 105 bits (251), Expect = 2e-21
Identities = 121/487 (24%), Positives = 196/487 (40%), Gaps = 45/487 (9%)
Query: 686 FHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLD 745
F V E G ++ + S G G+++++++ + G I + LD
Sbjct: 66 FFVLEEYTGT--DPLYVGKLHSDMDRGDGSIKYILSGEGAGIVFTIDDTTGDIHAIQRLD 123
Query: 746 REKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTE 805
RE+R Y + A + + I I+D NDN P F Y + E S +GT
Sbjct: 124 REERAQYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKFLDGPYVATVPEMSPVGTS 183
Query: 806 IKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSL 865
+ A D G +A +Y++ +G+ F VD TGV++ ++DRE K Y++ +
Sbjct: 184 VIQVTATDADDPTYGNSARVVYSIL-QGQPYFSVDSKTGVIRTALMNMDREAKEYYEVII 242
Query: 866 VARD----TGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
A+D GGL+ + I + D NDN P F Q ++ ++ + ++ T G
Sbjct: 243 QAKDMGGQLGGLAGTTTVNITLSDVNDNPPRFPQ--KHYQMSVLESAPISSTVG------ 294
Query: 922 KPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
FA D+D E I +K +D D I + N +V I
Sbjct: 295 ---RVFAKDLD---------EGI---NAEMKYTIVDGDGADAFDISTDPNFQVGI----- 334
Query: 982 SADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDH 1041
+ VK+ + + + P E R L+ G D +V + V+DV D
Sbjct: 335 ----ITVKKPLSFESKKSYTLKVEGANPHLEMRF----LNLGPFQDTTTVHISVEDV-DE 385
Query: 1042 FPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGV 1101
PVF+ +Y V E + + A D D N+ + SD F + TG
Sbjct: 386 PPVFEPGFYFVEVPEDVAIGTTIQIISAKDPDVTNNSIRYSIDRSSDPGRFFYVDITTGA 445
Query: 1102 LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWK 1161
L LDRE + +TV+A + DVNDN+P+F F E +
Sbjct: 446 LMTARPLDREEFSWHNITVLAMEMN-NPSQVGSVPVTIKVLDVNDNAPEFPRFYEAFVCE 504
Query: 1162 HPEADEL 1168
+ +A +L
Sbjct: 505 NAKAGQL 511
Score = 82.6 bits (195), Expect = 1e-14
Identities = 114/469 (24%), Positives = 195/469 (41%), Gaps = 47/469 (10%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVD---PDLGQNGMVLYDLQRTS 503
+ + D NDN P F+ Y ++ + VGT + +V A D P G + V+Y + +
Sbjct: 153 IKIQDINDNEPKFLDGP-YVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQGQ 211
Query: 504 NLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLA-VVTIEVTRG 562
F ++ TG + A ++ + E Q + + LA T+ +T
Sbjct: 212 PY-----FSVDSKTGVIRTALMN-MDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLS 265
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGY-EEGVP 619
+ P P F Y+ V + I ++VG++ D E ++ Y ++ G +
Sbjct: 266 DVNDNP--PRFPQKHYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFD 323
Query: 620 FAVEE--RSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT------NATVHV-VDVN 670
+ + + G+ITV LS ++ Y + + + + TVH+ V+
Sbjct: 324 ISTDPNFQVGIITVKKPLSFESKKSYTLKVEGANPHLEMRFLNLGPFQDTTTVHISVEDV 383
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
DE V G + V E+ A QI + N ++R+ I D
Sbjct: 384 DEPPVFEPGFY---FVEVPEDVAIGTTIQIISAKDPDVTNN---SIRYSIDRSSDPGRFF 437
Query: 731 AI-AEDGTIFTQKPLDREKRDVYRMTVIA-EFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ G + T +PLDRE+ + +TV+A E N S G VTI + D NDN P F
Sbjct: 438 YVDITTGALMTARPLDREEFSWHNITVLAMEMNNP--SQVGSVPVTIKVLDVNDNAPEFP 495
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNAL-FMYTLFGEGKE-----MFDVDEN 842
YE F+ EN+K G I+ + A D D+ N F Y+L E + D +N
Sbjct: 496 RF-YEAFVCENAKAGQLIQ---TVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDNQDN 551
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDN 889
T + ++++ ++ L ++ D+G LSS L I + +D+
Sbjct: 552 TARILTRRSGFRQQEQSVFHLPILIADSGQPVLSSTGTLTIQVCSCDDD 600
Score = 71.7 bits (168), Expect = 2e-11
Identities = 90/348 (25%), Positives = 152/348 (43%), Gaps = 31/348 (8%)
Query: 571 PDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQN-DVSYDLLHGYEEGVP-FAVEERSGV 628
P F+ PY V +GTSV Q+ DA + S +++ +G P F+V+ ++GV
Sbjct: 163 PKFLDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQGQPYFSVDSKTGV 222
Query: 629 I-TVVDDLSRYNRPMYDFEAVALQENANLS-IVTNATVHVV--DVNDERGVLLKGAHSPI 684
I T + ++ R + Y+ A L + TV++ DVND + +
Sbjct: 223 IRTALMNMDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVNDNPPRFPQKHYQMS 282
Query: 685 IFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED-----GTIF 739
+ ++ + +G++F ++ +++ I + D D I+ D G I
Sbjct: 283 V--LESAPISSTVGRVFAKDLDE---GINAEMKYTIVDG-DGADAFDISTDPNFQVGIIT 336
Query: 740 TQKPLDREKRDVYRMTVIAEFNKGV---ISGAGIYQ--VTIYIEDEN-DNPPVFEHATYE 793
+KPL E + Y + V N + G +Q T++I E+ D PPVFE Y
Sbjct: 337 VKKPLSFESKKSYTLKVEGA-NPHLEMRFLNLGPFQDTTTVHISVEDVDEPPVFEPGFYF 395
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNAL-FMYTLFGEGKEMFDVDENTGVVKFIGDS 852
+ E+ IGT I+ II A D D N++ + + F VD TG +
Sbjct: 396 VEVPEDVAIGTTIQ---IISAKDPDVTNNSIRYSIDRSSDPGRFFYVDITTGAL-MTARP 451
Query: 853 LDREKKIMYKLSLVARDTGGLS--SEAELIIMIGDENDNKPEFNQIEE 898
LDRE+ + ++++A + S + I + D NDN PEF + E
Sbjct: 452 LDREEFSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAPEFPRFYE 499
Score = 61.7 bits (143), Expect = 2e-08
Identities = 84/359 (23%), Positives = 144/359 (40%), Gaps = 28/359 (7%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L V +TL D NDN P F P Y+ S+ +A + + +G+V A D D G N + Y
Sbjct: 254 LAGTTTVNITLSDVNDNPPRF-PQKHYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYT 312
Query: 499 LQRTSNLTITSPFKINPN--TGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVT 556
+ +PN G ++V + E + + ++ + ANP L +
Sbjct: 313 IVDGDGAD-AFDISTDPNFQVGIITVKKPLSFESKKSYTLKV--EGANPHLEMRFLNLGP 369
Query: 557 IEVTRGTKGNKPDI---PDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQNDVSYDLLH 612
+ T + D+ P F Y V +V IGT++ I D N + Y +
Sbjct: 370 FQDTTTVHISVEDVDEPPVFEPGFYFVEVPEDVAIGTTIQIISAKDPDVTNNSIRYSIDR 429
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTN--ATVHVVDVN 670
+ G F V+ +G + L R ++ +A++ N N S V + T+ V+DVN
Sbjct: 430 SSDPGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMN-NPSQVGSVPVTIKVLDVN 488
Query: 671 DERGVLLKGAHSPIIFHVKEN---SAGAAIGQIFHTNMSSIY----GNGTGNVRFLIANQ 723
D + + + + K +A+ Q N Y N F I +
Sbjct: 489 DNAPEFPRFYEAFVCENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDN 548
Query: 724 QDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTV-IAEFNKGVISGAGIYQVTIYIEDEN 781
QD T I G F Q +++ V+ + + IA+ + V+S G + + D++
Sbjct: 549 QDNTARILTRRSG--FRQ-----QEQSVFHLPILIADSGQPVLSSTGTLTIQVCSCDDD 600
Score = 61.7 bits (143), Expect = 2e-08
Identities = 42/135 (31%), Positives = 66/135 (48%), Gaps = 8/135 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR-KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
I A D D+ ++RY + +D + F +D G+L + LD + + + + V
Sbjct: 411 ISAKDPDV-TNNSIRYSIDRSSDPGRFFYVDITTGALMTARPLDRE-----EFSWHNITV 464
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A ++NNP + V I++LD+NDN PEF FY + EN G + V A D+D
Sbjct: 465 LAMEMNNPSQVGSVPVTIKVLDVNDNAPEFP-RFYEAFVCENAKAGQLIQTVSAVDQDDP 523
Query: 337 ENGEFTYQLDDPKGA 351
NG+ Y P+ A
Sbjct: 524 RNGQHFYYSLAPEAA 538
Score = 59.7 bits (138), Expect = 8e-08
Identities = 50/185 (27%), Positives = 89/185 (48%), Gaps = 14/185 (7%)
Query: 213 LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLD--AEHNLQAN 270
L+ +H+ D D G G+ ++Y L +F++D G + + LD + A++ L+A
Sbjct: 78 LYVGKLHS-DMDRGDGS-IKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRA- 134
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
Q + P++ ++ I++ D+NDN P+F Y ++ E P G SV+QV A
Sbjct: 135 ----QALDRRTGRPMEP-ESEFIIKIQDINDNEPKFLDGPYVATVPEMSPVGTSVIQVTA 189
Query: 331 TDKDQ---GENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETN 387
TD D G + Y + + FS+D ++G + +DREA + + AK+
Sbjct: 190 TDADDPTYGNSARVVYSILQGQPYFSVDSKTGVIRTALMN-MDREAKEYYEVIIQAKDMG 248
Query: 388 PSVVG 392
+ G
Sbjct: 249 GQLGG 253
Score = 58.0 bits (134), Expect = 2e-07
Identities = 52/170 (30%), Positives = 79/170 (46%), Gaps = 16/170 (9%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D G A + Y ++ G + FS+DS G + +++D E + + +QA
Sbjct: 192 ADDPTYGNSARVVYSILQG--QPYFSVDSKTG-VIRTALMNMDREAK---EYYEVIIQAK 245
Query: 280 QLNNPLK--TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
+ L V I L D+NDN P F Y +S++E+ P +V +V A D D+G
Sbjct: 246 DMGGQLGGLAGTTTVNITLSDVNDNPPRFPQKHYQMSVLESAPISSTVGRVFAKDLDEGI 305
Query: 338 NGEFTYQLDDPKGA----FSIDP--RSGWLTVRNQTVLDREAHSSLRMKV 381
N E Y + D GA S DP + G +TV+ L E+ S +KV
Sbjct: 306 NAEMKYTIVDGDGADAFDISTDPNFQVGIITVKKP--LSFESKKSYTLKV 353
Score = 50.8 bits (116), Expect = 4e-05
Identities = 50/186 (26%), Positives = 83/186 (44%), Gaps = 14/186 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVN----GSLFLEKELDLDAE--HNLQANT 271
+ A D D G+ A ++Y ++ G+ F + + G + ++K L +++ + L+
Sbjct: 296 VFAKDLDEGINAEMKYTIVDGDGADAFDISTDPNFQVGIITVKKPLSFESKKSYTLKVEG 355
Query: 272 FVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMAT 331
++ LN V I + D+ D P FE FY + + E++ G ++ + A
Sbjct: 356 ANPHLEMRFLNLGPFQDTTTVHISVEDV-DEPPVFEPGFYFVEVPEDVAIGTTIQIISAK 414
Query: 332 DKDQGENGEFTYQLD---DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE-TN 387
D D N Y +D DP F +D +G L LDRE S + V A E N
Sbjct: 415 DPDV-TNNSIRYSIDRSSDPGRFFYVDITTGALMTARP--LDREEFSWHNITVLAMEMNN 471
Query: 388 PSVVGT 393
PS VG+
Sbjct: 472 PSQVGS 477
Score = 48.0 bits (109), Expect = 3e-04
Identities = 35/127 (27%), Positives = 58/127 (45%), Gaps = 20/127 (15%)
Query: 1293 YILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVA 1352
YIL+ I F ID G ++ ++ DRE + Y + +A ++ R + P +
Sbjct: 96 YILSGEGAGI--VFTIDDTTGDIHAIQRLDREERAQYTLRAQALDRRTGRPME----PES 149
Query: 1353 EDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQLKGAIGHHP 1412
E +++I+D+NDN PKF +G P V +P +P G V+Q+ P
Sbjct: 150 E------------FIIKIQDINDNEPKFLDG--PYVATVPEMSPVGTSVIQVTATDADDP 195
Query: 1413 TASRTVR 1419
T + R
Sbjct: 196 TYGNSAR 202
Score = 46.4 bits (105), Expect = 8e-04
Identities = 45/148 (30%), Positives = 72/148 (48%), Gaps = 18/148 (12%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PE++ IGTTI ++A D D N IRY + S+D R+F ++ G
Sbjct: 398 VPEDVAIGTTIQIISAKDPDV-TNNSIRYSIDR---------SSDP---GRFFYVDITTG 444
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVK--DVNDHFPVFKKTWYNFNVE 1055
++ AR L E S + + A++ N + SV V +K DVND+ P F + + F E
Sbjct: 445 ALMTARPLDREEFSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAPEFPRFYEAFVCE 504
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYF 1083
A+ +++ V A D D +N Y+
Sbjct: 505 NAK-AGQLIQTVSAVDQDDPRNGQHFYY 531
Score = 40.3 bits (90), Expect = 0.052
Identities = 16/29 (55%), Positives = 21/29 (72%)
Query: 85 VYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
+ I+D+NDN P FLD PY TV E++P G
Sbjct: 153 IKIQDINDNEPKFLDGPYVATVPEMSPVG 181
Score = 38.7 bits (86), Expect = 0.16
Identities = 31/106 (29%), Positives = 43/106 (40%), Gaps = 6/106 (5%)
Query: 1049 WYNFNVEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVN 1105
W F V E +YT +GK+ + D D G + ++ Y + + F I TG +
Sbjct: 63 WNQFFVLE-EYTGTDPLYVGKLHS-DMDRG-DGSIKYILSGEGAGIVFTIDDTTGDIHAI 119
Query: 1106 GELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
LDRE +Y L A D D+NDN PKF
Sbjct: 120 QRLDREERAQYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKF 165
Score = 33.5 bits (73), Expect = 6.0
Identities = 17/40 (42%), Positives = 25/40 (62%), Gaps = 1/40 (2%)
Query: 1182 YKATIEENAPIGTTVAKVFANDTDFIGNGNGL-ILYSLPQ 1220
Y AT+ E +P+GT+V +V A D D GN ++YS+ Q
Sbjct: 170 YVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQ 209
>BC101047-1|AAI01048.1| 801|Homo sapiens cadherin 20, type 2 protein.
Length = 801
Score = 105 bits (251), Expect = 2e-21
Identities = 121/487 (24%), Positives = 196/487 (40%), Gaps = 45/487 (9%)
Query: 686 FHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLD 745
F V E G ++ + S G G+++++++ + G I + LD
Sbjct: 66 FFVLEEYTGT--DPLYVGKLHSDMDRGDGSIKYILSGEGAGIVFTIDDTTGDIHAIQRLD 123
Query: 746 REKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTE 805
RE+R Y + A + + I I+D NDN P F Y + E S +GT
Sbjct: 124 REERAQYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKFLDGPYVATVPEMSPVGTS 183
Query: 806 IKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSL 865
+ A D G +A +Y++ +G+ F VD TGV++ ++DRE K Y++ +
Sbjct: 184 VIQVTATDADDPTYGNSARVVYSIL-QGQPYFSVDSKTGVIRTALMNMDREAKEYYEVII 242
Query: 866 VARD----TGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
A+D GGL+ + I + D NDN P F Q ++ ++ + ++ T G
Sbjct: 243 QAKDMGGQLGGLAGTTTVNITLSDVNDNPPRFPQ--KHYQMSVLESAPISSTVG------ 294
Query: 922 KPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
FA D+D E I +K +D D I + N +V I
Sbjct: 295 ---RVFAKDLD---------EGI---NAEMKYTIVDGDGADAFDISTDPNFQVGI----- 334
Query: 982 SADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDH 1041
+ VK+ + + + P E R L+ G D +V + V+DV D
Sbjct: 335 ----ITVKKPLSFESKKSYTLKVEGANPHLEMRF----LNLGPFQDTTTVHISVEDV-DE 385
Query: 1042 FPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGV 1101
PVF+ +Y V E + + A D D N+ + SD F + TG
Sbjct: 386 PPVFEPGFYFVEVPEDVAIGTTIQIISAKDPDVTNNSIRYSIDRSSDPGRFFYVDITTGA 445
Query: 1102 LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWK 1161
L LDRE + +TV+A + DVNDN+P+F F E +
Sbjct: 446 LMTARPLDREEFSWHNITVLAMEMN-NPSQVGSVPVTIKVLDVNDNAPEFPRFYEAFVCE 504
Query: 1162 HPEADEL 1168
+ +A +L
Sbjct: 505 NAKAGQL 511
Score = 82.6 bits (195), Expect = 1e-14
Identities = 114/469 (24%), Positives = 195/469 (41%), Gaps = 47/469 (10%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVD---PDLGQNGMVLYDLQRTS 503
+ + D NDN P F+ Y ++ + VGT + +V A D P G + V+Y + +
Sbjct: 153 IKIQDINDNEPKFLDGP-YVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQGQ 211
Query: 504 NLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLA-VVTIEVTRG 562
F ++ TG + A ++ + E Q + + LA T+ +T
Sbjct: 212 PY-----FSVDSKTGVIRTALMN-MDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLS 265
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGY-EEGVP 619
+ P P F Y+ V + I ++VG++ D E ++ Y ++ G +
Sbjct: 266 DVNDNP--PRFPQKHYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFD 323
Query: 620 FAVEE--RSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT------NATVHV-VDVN 670
+ + + G+ITV LS ++ Y + + + + TVH+ V+
Sbjct: 324 ISTDPNFQVGIITVKKPLSFESKKSYTLKVEGANPHLEMRFLNLGPFQDTTTVHISVEDV 383
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
DE V G + V E+ A QI + N ++R+ I D
Sbjct: 384 DEPPVFEPGFY---FVEVPEDVAIGTTIQIISAKDPDVTNN---SIRYSIDRSSDPGRFF 437
Query: 731 AI-AEDGTIFTQKPLDREKRDVYRMTVIA-EFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ G + T +PLDRE+ + +TV+A E N S G VTI + D NDN P F
Sbjct: 438 YVDITTGALMTARPLDREEFSWHNITVLAMEMNNP--SQVGSVPVTIKVLDVNDNAPEFP 495
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNAL-FMYTLFGEGKE-----MFDVDEN 842
YE F+ EN+K G I+ + A D D+ N F Y+L E + D +N
Sbjct: 496 RF-YEAFVCENAKAGQLIQ---TVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDNQDN 551
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDN 889
T + ++++ ++ L ++ D+G LSS L I + +D+
Sbjct: 552 TARILTRRSGFRQQEQSVFHLPILIADSGQPVLSSTGTLTIQVCSCDDD 600
Score = 71.7 bits (168), Expect = 2e-11
Identities = 90/348 (25%), Positives = 152/348 (43%), Gaps = 31/348 (8%)
Query: 571 PDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQN-DVSYDLLHGYEEGVP-FAVEERSGV 628
P F+ PY V +GTSV Q+ DA + S +++ +G P F+V+ ++GV
Sbjct: 163 PKFLDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQGQPYFSVDSKTGV 222
Query: 629 I-TVVDDLSRYNRPMYDFEAVALQENANLS-IVTNATVHVV--DVNDERGVLLKGAHSPI 684
I T + ++ R + Y+ A L + TV++ DVND + +
Sbjct: 223 IRTALMNMDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVNDNPPRFPQKHYQMS 282
Query: 685 IFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED-----GTIF 739
+ ++ + +G++F ++ +++ I + D D I+ D G I
Sbjct: 283 V--LESAPISSTVGRVFAKDLDE---GINAEMKYTIVDG-DGADAFDISTDPNFQVGIIT 336
Query: 740 TQKPLDREKRDVYRMTVIAEFNKGV---ISGAGIYQ--VTIYIEDEN-DNPPVFEHATYE 793
+KPL E + Y + V N + G +Q T++I E+ D PPVFE Y
Sbjct: 337 VKKPLSFESKKSYTLKVEGA-NPHLEMRFLNLGPFQDTTTVHISVEDVDEPPVFEPGFYF 395
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNAL-FMYTLFGEGKEMFDVDENTGVVKFIGDS 852
+ E+ IGT I+ II A D D N++ + + F VD TG +
Sbjct: 396 VEVPEDVAIGTTIQ---IISAKDPDVTNNSIRYSIDRSSDPGRFFYVDITTGAL-MTARP 451
Query: 853 LDREKKIMYKLSLVARDTGGLS--SEAELIIMIGDENDNKPEFNQIEE 898
LDRE+ + ++++A + S + I + D NDN PEF + E
Sbjct: 452 LDREEFSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAPEFPRFYE 499
Score = 61.7 bits (143), Expect = 2e-08
Identities = 84/359 (23%), Positives = 144/359 (40%), Gaps = 28/359 (7%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L V +TL D NDN P F P Y+ S+ +A + + +G+V A D D G N + Y
Sbjct: 254 LAGTTTVNITLSDVNDNPPRF-PQKHYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYT 312
Query: 499 LQRTSNLTITSPFKINPN--TGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVT 556
+ +PN G ++V + E + + ++ + ANP L +
Sbjct: 313 IVDGDGAD-AFDISTDPNFQVGIITVKKPLSFESKKSYTLKV--EGANPHLEMRFLNLGP 369
Query: 557 IEVTRGTKGNKPDI---PDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQNDVSYDLLH 612
+ T + D+ P F Y V +V IGT++ I D N + Y +
Sbjct: 370 FQDTTTVHISVEDVDEPPVFEPGFYFVEVPEDVAIGTTIQIISAKDPDVTNNSIRYSIDR 429
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTN--ATVHVVDVN 670
+ G F V+ +G + L R ++ +A++ N N S V + T+ V+DVN
Sbjct: 430 SSDPGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMN-NPSQVGSVPVTIKVLDVN 488
Query: 671 DERGVLLKGAHSPIIFHVKEN---SAGAAIGQIFHTNMSSIY----GNGTGNVRFLIANQ 723
D + + + + K +A+ Q N Y N F I +
Sbjct: 489 DNAPEFPRFYEAFVCENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDN 548
Query: 724 QDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTV-IAEFNKGVISGAGIYQVTIYIEDEN 781
QD T I G F Q +++ V+ + + IA+ + V+S G + + D++
Sbjct: 549 QDNTARILTRRSG--FRQ-----QEQSVFHLPILIADSGQPVLSSTGTLTIQVCSCDDD 600
Score = 61.7 bits (143), Expect = 2e-08
Identities = 42/135 (31%), Positives = 66/135 (48%), Gaps = 8/135 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR-KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
I A D D+ ++RY + +D + F +D G+L + LD + + + + V
Sbjct: 411 ISAKDPDV-TNNSIRYSIDRSSDPGRFFYVDITTGALMTARPLDRE-----EFSWHNITV 464
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A ++NNP + V I++LD+NDN PEF FY + EN G + V A D+D
Sbjct: 465 LAMEMNNPSQVGSVPVTIKVLDVNDNAPEFP-RFYEAFVCENAKAGQLIQTVSAVDQDDP 523
Query: 337 ENGEFTYQLDDPKGA 351
NG+ Y P+ A
Sbjct: 524 RNGQHFYYSLAPEAA 538
Score = 59.7 bits (138), Expect = 8e-08
Identities = 50/185 (27%), Positives = 89/185 (48%), Gaps = 14/185 (7%)
Query: 213 LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLD--AEHNLQAN 270
L+ +H+ D D G G+ ++Y L +F++D G + + LD + A++ L+A
Sbjct: 78 LYVGKLHS-DMDRGDGS-IKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRA- 134
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
Q + P++ ++ I++ D+NDN P+F Y ++ E P G SV+QV A
Sbjct: 135 ----QALDRRTGRPMEP-ESEFIIKIQDINDNEPKFLDGPYVATVPEMSPVGTSVIQVTA 189
Query: 331 TDKDQ---GENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETN 387
TD D G + Y + + FS+D ++G + +DREA + + AK+
Sbjct: 190 TDADDPTYGNSARVVYSILQGQPYFSVDSKTGVIRTALMN-MDREAKEYYEVIIQAKDMG 248
Query: 388 PSVVG 392
+ G
Sbjct: 249 GQLGG 253
Score = 58.0 bits (134), Expect = 2e-07
Identities = 52/170 (30%), Positives = 79/170 (46%), Gaps = 16/170 (9%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D G A + Y ++ G + FS+DS G + +++D E + + +QA
Sbjct: 192 ADDPTYGNSARVVYSILQG--QPYFSVDSKTG-VIRTALMNMDREAK---EYYEVIIQAK 245
Query: 280 QLNNPLK--TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
+ L V I L D+NDN P F Y +S++E+ P +V +V A D D+G
Sbjct: 246 DMGGQLGGLAGTTTVNITLSDVNDNPPRFPQKHYQMSVLESAPISSTVGRVFAKDLDEGI 305
Query: 338 NGEFTYQLDDPKGA----FSIDP--RSGWLTVRNQTVLDREAHSSLRMKV 381
N E Y + D GA S DP + G +TV+ L E+ S +KV
Sbjct: 306 NAEMKYTIVDGDGADAFDISTDPNFQVGIITVKKP--LSFESKKSYTLKV 353
Score = 50.8 bits (116), Expect = 4e-05
Identities = 50/186 (26%), Positives = 83/186 (44%), Gaps = 14/186 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVN----GSLFLEKELDLDAE--HNLQANT 271
+ A D D G+ A ++Y ++ G+ F + + G + ++K L +++ + L+
Sbjct: 296 VFAKDLDEGINAEMKYTIVDGDGADAFDISTDPNFQVGIITVKKPLSFESKKSYTLKVEG 355
Query: 272 FVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMAT 331
++ LN V I + D+ D P FE FY + + E++ G ++ + A
Sbjct: 356 ANPHLEMRFLNLGPFQDTTTVHISVEDV-DEPPVFEPGFYFVEVPEDVAIGTTIQIISAK 414
Query: 332 DKDQGENGEFTYQLD---DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE-TN 387
D D N Y +D DP F +D +G L LDRE S + V A E N
Sbjct: 415 DPDV-TNNSIRYSIDRSSDPGRFFYVDITTGALMTARP--LDREEFSWHNITVLAMEMNN 471
Query: 388 PSVVGT 393
PS VG+
Sbjct: 472 PSQVGS 477
Score = 48.0 bits (109), Expect = 3e-04
Identities = 35/127 (27%), Positives = 58/127 (45%), Gaps = 20/127 (15%)
Query: 1293 YILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVA 1352
YIL+ I F ID G ++ ++ DRE + Y + +A ++ R + P +
Sbjct: 96 YILSGEGAGI--VFTIDDTTGDIHAIQRLDREERAQYTLRAQALDRRTGRPME----PES 149
Query: 1353 EDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQLKGAIGHHP 1412
E +++I+D+NDN PKF +G P V +P +P G V+Q+ P
Sbjct: 150 E------------FIIKIQDINDNEPKFLDG--PYVATVPEMSPVGTSVIQVTATDADDP 195
Query: 1413 TASRTVR 1419
T + R
Sbjct: 196 TYGNSAR 202
Score = 46.4 bits (105), Expect = 8e-04
Identities = 45/148 (30%), Positives = 72/148 (48%), Gaps = 18/148 (12%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PE++ IGTTI ++A D D N IRY + S+D R+F ++ G
Sbjct: 398 VPEDVAIGTTIQIISAKDPDV-TNNSIRYSIDR---------SSDP---GRFFYVDITTG 444
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVK--DVNDHFPVFKKTWYNFNVE 1055
++ AR L E S + + A++ N + SV V +K DVND+ P F + + F E
Sbjct: 445 ALMTARPLDREEFSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAPEFPRFYEAFVCE 504
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYF 1083
A+ +++ V A D D +N Y+
Sbjct: 505 NAK-AGQLIQTVSAVDQDDPRNGQHFYY 531
Score = 40.3 bits (90), Expect = 0.052
Identities = 16/29 (55%), Positives = 21/29 (72%)
Query: 85 VYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
+ I+D+NDN P FLD PY TV E++P G
Sbjct: 153 IKIQDINDNEPKFLDGPYVATVPEMSPVG 181
Score = 38.7 bits (86), Expect = 0.16
Identities = 31/106 (29%), Positives = 43/106 (40%), Gaps = 6/106 (5%)
Query: 1049 WYNFNVEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVN 1105
W F V E +YT +GK+ + D D G + ++ Y + + F I TG +
Sbjct: 63 WNQFFVLE-EYTGTDPLYVGKLHS-DMDRG-DGSIKYILSGEGAGIVFTIDDTTGDIHAI 119
Query: 1106 GELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
LDRE +Y L A D D+NDN PKF
Sbjct: 120 QRLDREERAQYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKF 165
Score = 33.5 bits (73), Expect = 6.0
Identities = 17/40 (42%), Positives = 25/40 (62%), Gaps = 1/40 (2%)
Query: 1182 YKATIEENAPIGTTVAKVFANDTDFIGNGNGL-ILYSLPQ 1220
Y AT+ E +P+GT+V +V A D D GN ++YS+ Q
Sbjct: 170 YVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQ 209
>BC051788-1|AAH51788.1| 929|Homo sapiens protocadherin gamma
subfamily B, 7 protein.
Length = 929
Score = 105 bits (251), Expect = 2e-21
Identities = 118/477 (24%), Positives = 200/477 (41%), Gaps = 39/477 (8%)
Query: 432 IEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNL-YEFSMKSNAKVGTVIGKVKAVDPDLG 490
+E E ++ +V V + D ND+ P F + E S + +GT++ A DPD+
Sbjct: 106 LEAVVENPLNIFHVIVVIEDVNDHAPQFRKDEINLEISESVSLGMGTILES--AEDPDIS 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVS--VAESPI---LEGRHALFVEASDQPANP 545
N + Y L ++ K NP+ G V + + + H L + A D P
Sbjct: 164 MNSLSKYQLSPNEYFSLVE--KDNPDGGKYPELVLQKTLDRETQSAHHLVLTALDGGDPP 221
Query: 546 SERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--Q 603
+ ++ I+ + P P F Y + +V GTS+ +++ D E
Sbjct: 222 RSGTAQIRILVIDAN-----DNP--PVFSQDVYRVSLREDVPPGTSILRVKATDQDEGIN 274
Query: 604 NDVSYDLLHGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNA 662
++++Y ++ F+++ +G I L Y A ++ +LS
Sbjct: 275 SEITYSFFGVADKAQHVFSLDYTTGNILTQQPLDFEEVERYTINIEA-KDRGSLSTRCKV 333
Query: 663 TVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIAN 722
V VVD ND ++ + S + E+S + +F T NG VR ++
Sbjct: 334 IVEVVDENDNSPEIIITSLSD---QIMEDSPPGVVVALFKTRDQDSGENG--EVRCSLSR 388
Query: 723 QQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEND 782
+ + T + LDRE+ Y +T+ A ++G + +T++I D ND
Sbjct: 389 GVPFKIHSSSNNYYKLVTDEALDREQTPEYNVTIAAT-DRGKPPLSSSKTITLHITDVND 447
Query: 783 NPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKE------M 836
N PVF + Y + EN++ G I + A+D D G N Y+L E
Sbjct: 448 NAPVFGQSAYLVHVPENNQPGASIAQ---VSASDPDFGLNGRVSYSLIASDLESRTLSSY 504
Query: 837 FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +GVV F + D E+ ++L+L ARD G LS+ L +++GD NDN P
Sbjct: 505 VSVSAQSGVV-FAQRAFDHEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAP 560
Score = 103 bits (247), Expect = 5e-21
Identities = 94/329 (28%), Positives = 150/329 (45%), Gaps = 27/329 (8%)
Query: 577 PYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLS 636
P + + + G+ VG + + DVS L E + F+V+ +SG + V D +
Sbjct: 32 PIRYSIPEELAKGSVVGNLAKDLGLSVLDVSARELRVSAEKLHFSVDAQSGDLLVKDRID 91
Query: 637 RYN----RPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENS 692
R R + + A+ EN L+I + V + DVND K I + E S
Sbjct: 92 REQICKERRRCELQLEAVVENP-LNIF-HVIVVIEDVNDHAPQFRK---DEINLEISE-S 145
Query: 693 AGAAIGQIFHT------NMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDR 746
+G I + +M+S+ + ++D D E + QK LDR
Sbjct: 146 VSLGMGTILESAEDPDISMNSLSKYQLSPNEYFSLVEKDNPDGGKYPE---LVLQKTLDR 202
Query: 747 EKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEI 806
E + + + V+ + G +G Q+ I + D NDNPPVF Y + E+ GT I
Sbjct: 203 ETQSAHHL-VLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRVSLREDVPPGTSI 261
Query: 807 KMDNIIKATDADEGTNALFMYTLFG---EGKEMFDVDENTGVVKFIGDSLDREKKIMYKL 863
+KATD DEG N+ Y+ FG + + +F +D TG + LD E+ Y +
Sbjct: 262 LR---VKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGNI-LTQQPLDFEEVERYTI 317
Query: 864 SLVARDTGGLSSEAELIIMIGDENDNKPE 892
++ A+D G LS+ ++I+ + DENDN PE
Sbjct: 318 NIEAKDRGSLSTRCKVIVEVVDENDNSPE 346
Score = 78.6 bits (185), Expect = 2e-13
Identities = 51/170 (30%), Positives = 84/170 (49%), Gaps = 7/170 (4%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D+ + + +Y+L L D+ +G + E L + Q+ L + A
Sbjct: 157 AEDPDISMNSLSKYQLSPNEYFSLVEKDNPDGGKYPELVLQKTLDRETQS-AHHLVLTAL 215
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
+P ++ A++ I ++D NDN P F D Y +S+ E++P G S+L+V ATD+D+G N
Sbjct: 216 DGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRVSLREDVPPGTSILRVKATDQDEGINS 275
Query: 340 EFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
E TY D + FS+D +G + Q LD E + + AK+
Sbjct: 276 EITYSFFGVADKAQHVFSLDYTTG--NILTQQPLDFEEVERYTINIEAKD 323
Score = 72.9 bits (171), Expect = 8e-12
Identities = 69/264 (26%), Positives = 116/264 (43%), Gaps = 22/264 (8%)
Query: 897 EENSKVRIHRETKLNGTAGF---TIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKL 953
EE + I+ E K G+ I+EV +N + ++ I E+ P G +
Sbjct: 310 EEVERYTINIEAKDRGSLSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGVVVALF 369
Query: 954 NALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEF 1013
D DSG NG++R + V P K+ + + Y ++ + + R PE +
Sbjct: 370 KTRDQDSGENGEVRCSLSRGV---PFKIHSSSNNY--YKLVTDE----ALDREQTPE--Y 418
Query: 1014 RLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATD 1071
+ I+A D G L+ + ++ + + DVND+ PVF ++ Y +V E + +V A+D
Sbjct: 419 NVTIAATDRGKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVPENNQPGASIAQVSASD 478
Query: 1072 ADFGQNANLTYFIQPSDTDLP-----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
DFG N ++Y + SD + +S +GV+ D E + LT+ ARD G
Sbjct: 479 PDFGLNGRVSYSLIASDLESRTLSSYVSVSAQSGVVFAQRAFDHEQLRTFELTLQARDQG 538
Query: 1127 XXXXXXXXXXXXXXXXDVNDNSPK 1150
D NDN+P+
Sbjct: 539 -SPALSANVSLRVLVGDRNDNAPR 561
Score = 72.1 bits (169), Expect = 1e-11
Identities = 96/415 (23%), Positives = 179/415 (43%), Gaps = 35/415 (8%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I E++ +G I +A D D +N +Y+ + Y S + D + +Y
Sbjct: 142 ISESVSLGMGTILESAEDPDISMNSLSKYQLSPNEYF--SLVEKDNPDGGKY-------P 192
Query: 1000 HVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+++ ++L E++ L ++ALDGG+ + +R+ V D ND+ PVF + Y ++
Sbjct: 193 ELVLQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRVSLR 252
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTY-FIQPSD-TDLPFEISPLTGVLSVNGELDRETE 1113
E + +V ATD D G N+ +TY F +D F + TG + LD E
Sbjct: 253 EDVPPGTSILRVKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGNILTQQPLDFEEV 312
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY---AFDELLEWKHP-EADELS 1169
++Y + + A+D G D NDNSP+ D+++E P L
Sbjct: 313 ERYTINIEAKDRG---SLSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGVVVALF 369
Query: 1170 NHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL 1227
+ + ++ P I ++ + TD + Y++ +
Sbjct: 370 KTRDQDSGENGEVRCSLSRGVPFKIHSSSNNYYKLVTDEALDREQTPEYNVTIAATDR-- 427
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSLNLTEHY 1285
G P LSS+ + + + DV D + PVF Y + + EN A + VS + +
Sbjct: 428 GKPPLSSSKTITLHITDVND-----NAPVFGQSAYLVHVPENNQPGASIAQVSASDPDFG 482
Query: 1286 ENFKMRY-YILNENDTDIRRTFV-IDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
N ++ Y I ++ ++ ++V + ++G ++ R+ D E T+E+ ++A Q
Sbjct: 483 LNGRVSYSLIASDLESRTLSSYVSVSAQSGVVFAQRAFDHEQLRTFELTLQARDQ 537
Score = 65.7 bits (153), Expect = 1e-09
Identities = 52/163 (31%), Positives = 78/163 (47%), Gaps = 10/163 (6%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I TQ+PLD E+ + Y + + A+ ++G +S +V + + DENDN P +
Sbjct: 299 GNILTQQPLDFEEVERYTINIEAK-DRGSLSTR--CKVIVEVVDENDNSPEIIITSLSDQ 355
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD-SLD 854
IME+S G + + K D D G N +L G + K + D +LD
Sbjct: 356 IMEDSPPGVVVAL---FKTRDQDSGENGEVRCSL-SRGVPFKIHSSSNNYYKLVTDEALD 411
Query: 855 REKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
RE+ Y +++ A D G LSS + + I D NDN P F Q
Sbjct: 412 REQTPEYNVTIAATDRGKPPLSSSKTITLHITDVNDNAPVFGQ 454
Score = 62.5 bits (145), Expect = 1e-08
Identities = 47/172 (27%), Positives = 80/172 (46%), Gaps = 13/172 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRK--LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A DQD G+ + + Y D+ +FSLD G++ ++ LD + + + +
Sbjct: 264 VKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGNILTQQPLDFE-----EVERYTIN 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
++A + L T + +V +E++D NDN PE + + I+E+ P G V D+D
Sbjct: 319 IEAKDRGS-LST-RCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGVVVALFKTRDQDS 376
Query: 336 GENGEFTYQLDDPKGA-FSIDPRS-GWLTVRNQTVLDREAHSSLRMKVYAKE 385
GENGE L +G F I S + + LDRE + + A +
Sbjct: 377 GENGEVRCSLS--RGVPFKIHSSSNNYYKLVTDEALDREQTPEYNVTIAATD 426
Score = 60.1 bits (139), Expect = 6e-08
Identities = 61/199 (30%), Positives = 94/199 (47%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN G +I +++A D D GLNG++ Y + S L + L Y ++ + G
Sbjct: 461 VPENNQPGASIAQVSASDPDFGLNGRVSYSLIA------SDLESRTLS--SYVSVSAQSG 512
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFP--VFKKTWYNFN 1053
V R+ E F L + A D G+ L+ N+S+RV V D ND+ P ++ + +
Sbjct: 513 VVFAQRAFDHEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGS 572
Query: 1054 -----VEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSDTDLPFEISPLTGVLSVNGE 1107
V A ++ KV A DAD G NA L+Y +Q S+ L F + TG + +
Sbjct: 573 ALFDTVPRAAQPGYLVTKVVAVDADSGHNAWLSYHVVQASEPGL-FSLGLRTGEVRMVRA 631
Query: 1108 LDRETEDKYILTVVARDNG 1126
L + + L V RD G
Sbjct: 632 LGDKDSVRQRLLVAVRDGG 650
Score = 59.7 bits (138), Expect = 8e-08
Identities = 68/276 (24%), Positives = 110/276 (39%), Gaps = 15/276 (5%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRG 137
S + + + D NDN P+F Y V++ E P G + +T
Sbjct: 223 SGTAQIRILVIDANDNPPVFSQDVYRVSLREDVPPGTSILRVKATDQDEGINSEITYSFF 282
Query: 138 LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGH-FALESSHKPVLLLR-KVLD--YDAG 193
K F D T N + + + +E+ + L R KV+ D
Sbjct: 283 GVADKAQHVFSLDY-TTGNILTQQPLDFEEVERYTINIEAKDRGSLSTRCKVIVEVVDEN 341
Query: 194 DKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGATLRYELISGNDRKLFSLDSV 249
D +++I + +I ++ P + A+ DQD G +R L G K+ S S
Sbjct: 342 DNSPEIIITSLSDQIMEDSP-PGVVVALFKTRDQDSGENGEVRCSLSRGVPFKIHS--SS 398
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
N L + LD E + N + + A+ P ++ + + + D+NDN P F
Sbjct: 399 NNYYKLVTDEALDREQTPEYN---VTIAATDRGKPPLSSSKTITLHITDVNDNAPVFGQS 455
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
Y + + EN G S+ QV A+D D G NG +Y L
Sbjct: 456 AYLVHVPENNQPGASIAQVSASDPDFGLNGRVSYSL 491
Score = 53.6 bits (123), Expect = 5e-06
Identities = 48/169 (28%), Positives = 75/169 (44%), Gaps = 9/169 (5%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
A+ G + + +DRE+ R + V + I+ V + IED ND+ P F
Sbjct: 79 AQSGDLLVKDRIDREQICKERRRCELQLEAVVENPLNIFHVIVVIEDVNDHAPQFRKDEI 138
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG---VVKF 848
I E+ +G +++ A D D N+L Y L E + + D G
Sbjct: 139 NLEISESVSLGMGTILES---AEDPDISMNSLSKYQLSPNEYFSLVEKDNPDGGKYPELV 195
Query: 849 IGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+ +LDRE + + L L A D G S A++ I++ D NDN P F+Q
Sbjct: 196 LQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQ 244
Score = 50.8 bits (116), Expect = 4e-05
Identities = 77/310 (24%), Positives = 126/310 (40%), Gaps = 39/310 (12%)
Query: 77 ISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP--IGPSLTIPLTV 134
+S V V + D NDN P + T + E +P G +F G + + ++
Sbjct: 327 LSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGVVVALFKTRDQDSGENGEVRCSL 386
Query: 135 PRGLTI---------FKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR 185
RG+ +K + D+ TP +V ++ D G L SS L +
Sbjct: 387 SRGVPFKIHSSSNNYYKLVTDEALDREQTPEYNV---TIAATDRGKPPLSSSKTITLHIT 443
Query: 186 KVLDY-DAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGN--DRK 242
V D + LV + + I + A D D G+ + Y LI+ + R
Sbjct: 444 DVNDNAPVFGQSAYLVHVPENNQPGASIA---QVSASDPDFGLNGRVSYSLIASDLESRT 500
Query: 243 LFSLDSVN---GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
L S SV+ G +F ++ D + Q TF L +QA +P +A + + + D
Sbjct: 501 LSSYVSVSAQSGVVFAQRAFDHE-----QLRTFELTLQARDQGSPALSANVSLRVLVGDR 555
Query: 300 NDNLPEF---EVDFYNISIVENLPN----GFSVLQVMATDKDQGENGEFTY---QLDDPK 349
NDN P + ++ + +P G+ V +V+A D D G N +Y Q +P
Sbjct: 556 NDNAPRVLYPALGPDGSALFDTVPRAAQPGYLVTKVVAVDADSGHNAWLSYHVVQASEP- 614
Query: 350 GAFSIDPRSG 359
G FS+ R+G
Sbjct: 615 GLFSLGLRTG 624
Score = 50.4 bits (115), Expect = 5e-05
Identities = 49/162 (30%), Positives = 75/162 (46%), Gaps = 10/162 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D L V EL ++ FS+D+ +G L ++ +D + + + LQ++A
Sbjct: 51 AKDLGLSVLDVSARELRVSAEKLHFSVDAQSGDLLVKDRIDRE-QICKERRRCELQLEAV 109
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
+ NPL V IE D+ND+ P+F D N+ I E++ G + A D D N
Sbjct: 110 -VENPLNIFHVIVVIE--DVNDHAPQFRKDEINLEISESVSLGMGTILESAEDPDISMNS 166
Query: 340 EFTYQLDDPKGAFSI----DPRSG-WLTVRNQTVLDREAHSS 376
YQL P FS+ +P G + + Q LDRE S+
Sbjct: 167 LSKYQL-SPNEYFSLVEKDNPDGGKYPELVLQKTLDRETQSA 207
Score = 45.6 bits (103), Expect = 0.001
Identities = 37/125 (29%), Positives = 52/125 (41%), Gaps = 5/125 (4%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD-T 1089
V V ++DVNDH P F+K N + E+ A D D N+ Y + P++
Sbjct: 119 VIVVIEDVNDHAPQFRKDEINLEISESVSLGMGTILESAEDPDISMNSLSKYQLSPNEYF 178
Query: 1090 DLPFEISPLTG---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
L + +P G L + LDRET+ + L + A D G D ND
Sbjct: 179 SLVEKDNPDGGKYPELVLQKTLDRETQSAHHLVLTALDGG-DPPRSGTAQIRILVIDAND 237
Query: 1147 NSPKF 1151
N P F
Sbjct: 238 NPPVF 242
Score = 33.9 bits (74), Expect = 4.5
Identities = 16/41 (39%), Positives = 24/41 (58%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G +S+ ++T++I DVNDN P+F + Y V V E G
Sbjct: 428 GKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVPENNQPG 468
>AF217289-1|AAG23739.1| 801|Homo sapiens cadherin 20 protein.
Length = 801
Score = 105 bits (251), Expect = 2e-21
Identities = 121/487 (24%), Positives = 196/487 (40%), Gaps = 45/487 (9%)
Query: 686 FHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLD 745
F V E G ++ + S G G+++++++ + G I + LD
Sbjct: 66 FFVLEEYTGT--DPLYVGKLHSDMDRGDGSIKYILSGEGAGIVFTIDDTTGDIHAIQRLD 123
Query: 746 REKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTE 805
RE+R Y + A + + I I+D NDN P F Y + E S +GT
Sbjct: 124 REERAQYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKFLDGPYVATVPEMSPVGTS 183
Query: 806 IKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSL 865
+ A D G +A +Y++ +G+ F VD TGV++ ++DRE K Y++ +
Sbjct: 184 VIQVTATDADDPTYGNSARVVYSIL-QGQPYFSVDSKTGVIRTALMNMDREAKEYYEVII 242
Query: 866 VARD----TGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEV 921
A+D GGL+ + I + D NDN P F Q ++ ++ + ++ T G
Sbjct: 243 QAKDMGGQLGGLAGTTTVNITLSDVNDNPPRFPQ--KHYQMSVLESAPISSTVG------ 294
Query: 922 KPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
FA D+D E I +K +D D I + N +V I
Sbjct: 295 ---RVFAKDLD---------EGI---NAEMKYTIVDGDGADAFDISTDPNFQVGI----- 334
Query: 982 SADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVFVKDVNDH 1041
+ VK+ + + + P E R L+ G D +V + V+DV D
Sbjct: 335 ----ITVKKPLSFESKKSYTLKVEGANPHLEMRF----LNLGPFQDTTTVHISVEDV-DE 385
Query: 1042 FPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGV 1101
PVF+ +Y V E + + A D D N+ + SD F + TG
Sbjct: 386 PPVFEPGFYFVEVPEDVAIGTTIQIISAKDPDVTNNSIRYSIDRSSDPGRFFYVDITTGA 445
Query: 1102 LSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWK 1161
L LDRE + +TV+A + DVNDN+P+F F E +
Sbjct: 446 LMTARPLDREEFSWHNITVLAMEMN-NPSQVGSVPVTIKVLDVNDNAPEFPRFYEAFVCE 504
Query: 1162 HPEADEL 1168
+ +A +L
Sbjct: 505 NAKAGQL 511
Score = 82.6 bits (195), Expect = 1e-14
Identities = 114/469 (24%), Positives = 195/469 (41%), Gaps = 47/469 (10%)
Query: 447 VTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVD---PDLGQNGMVLYDLQRTS 503
+ + D NDN P F+ Y ++ + VGT + +V A D P G + V+Y + +
Sbjct: 153 IKIQDINDNEPKFLDGP-YVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQGQ 211
Query: 504 NLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLA-VVTIEVTRG 562
F ++ TG + A ++ + E Q + + LA T+ +T
Sbjct: 212 PY-----FSVDSKTGVIRTALMN-MDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLS 265
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGY-EEGVP 619
+ P P F Y+ V + I ++VG++ D E ++ Y ++ G +
Sbjct: 266 DVNDNP--PRFPQKHYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFD 323
Query: 620 FAVEE--RSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVT------NATVHV-VDVN 670
+ + + G+ITV LS ++ Y + + + + TVH+ V+
Sbjct: 324 ISTDPNFQVGIITVKKPLSFESKKSYTLKVEGANPHLEMRFLNLGPFQDTTTVHISVEDV 383
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
DE V G + V E+ A QI + N ++R+ I D
Sbjct: 384 DEPPVFEPGFY---FVEVPEDVAIGTTIQIISAKDPDVTNN---SIRYSIDRSSDPGRFF 437
Query: 731 AI-AEDGTIFTQKPLDREKRDVYRMTVIA-EFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+ G + T +PLDRE+ + +TV+A E N S G VTI + D NDN P F
Sbjct: 438 YVDITTGALMTARPLDREEFSWHNITVLAMEMNNP--SQVGSVPVTIKVLDVNDNAPEFP 495
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNAL-FMYTLFGEGKE-----MFDVDEN 842
YE F+ EN+K G I+ + A D D+ N F Y+L E + D +N
Sbjct: 496 RF-YEAFVCENAKAGQLIQ---TVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDNQDN 551
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDN 889
T + ++++ ++ L ++ D+G LSS L I + +D+
Sbjct: 552 TARILTRRSGFRQQEQSVFHLPILIADSGQPVLSSTGTLTIQVCSCDDD 600
Score = 71.7 bits (168), Expect = 2e-11
Identities = 90/348 (25%), Positives = 152/348 (43%), Gaps = 31/348 (8%)
Query: 571 PDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQN-DVSYDLLHGYEEGVP-FAVEERSGV 628
P F+ PY V +GTSV Q+ DA + S +++ +G P F+V+ ++GV
Sbjct: 163 PKFLDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQGQPYFSVDSKTGV 222
Query: 629 I-TVVDDLSRYNRPMYDFEAVALQENANLS-IVTNATVHVV--DVNDERGVLLKGAHSPI 684
I T + ++ R + Y+ A L + TV++ DVND + +
Sbjct: 223 IRTALMNMDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVNDNPPRFPQKHYQMS 282
Query: 685 IFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED-----GTIF 739
+ ++ + +G++F ++ +++ I + D D I+ D G I
Sbjct: 283 V--LESAPISSTVGRVFAKDLDE---GINAEMKYTIVDG-DGADAFDISTDPNFQVGIIT 336
Query: 740 TQKPLDREKRDVYRMTVIAEFNKGV---ISGAGIYQ--VTIYIEDEN-DNPPVFEHATYE 793
+KPL E + Y + V N + G +Q T++I E+ D PPVFE Y
Sbjct: 337 VKKPLSFESKKSYTLKVEGA-NPHLEMRFLNLGPFQDTTTVHISVEDVDEPPVFEPGFYF 395
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNAL-FMYTLFGEGKEMFDVDENTGVVKFIGDS 852
+ E+ IGT I+ II A D D N++ + + F VD TG +
Sbjct: 396 VEVPEDVAIGTTIQ---IISAKDPDVTNNSIRYSIDRSSDPGRFFYVDITTGAL-MTARP 451
Query: 853 LDREKKIMYKLSLVARDTGGLS--SEAELIIMIGDENDNKPEFNQIEE 898
LDRE+ + ++++A + S + I + D NDN PEF + E
Sbjct: 452 LDREEFSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAPEFPRFYE 499
Score = 61.7 bits (143), Expect = 2e-08
Identities = 84/359 (23%), Positives = 144/359 (40%), Gaps = 28/359 (7%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L V +TL D NDN P F P Y+ S+ +A + + +G+V A D D G N + Y
Sbjct: 254 LAGTTTVNITLSDVNDNPPRF-PQKHYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYT 312
Query: 499 LQRTSNLTITSPFKINPN--TGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVT 556
+ +PN G ++V + E + + ++ + ANP L +
Sbjct: 313 IVDGDGAD-AFDISTDPNFQVGIITVKKPLSFESKKSYTLKV--EGANPHLEMRFLNLGP 369
Query: 557 IEVTRGTKGNKPDI---PDFMGAPYEFWVGSNVGIGTSVGQIRVNDA-FEQNDVSYDLLH 612
+ T + D+ P F Y V +V IGT++ I D N + Y +
Sbjct: 370 FQDTTTVHISVEDVDEPPVFEPGFYFVEVPEDVAIGTTIQIISAKDPDVTNNSIRYSIDR 429
Query: 613 GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTN--ATVHVVDVN 670
+ G F V+ +G + L R ++ +A++ N N S V + T+ V+DVN
Sbjct: 430 SSDPGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMN-NPSQVGSVPVTIKVLDVN 488
Query: 671 DERGVLLKGAHSPIIFHVKEN---SAGAAIGQIFHTNMSSIY----GNGTGNVRFLIANQ 723
D + + + + K +A+ Q N Y N F I +
Sbjct: 489 DNAPEFPRFYEAFVCENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDN 548
Query: 724 QDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTV-IAEFNKGVISGAGIYQVTIYIEDEN 781
QD T I G F Q +++ V+ + + IA+ + V+S G + + D++
Sbjct: 549 QDNTARILTRRSG--FRQ-----QEQSVFHLPILIADSGQPVLSSTGTLTIQVCSCDDD 600
Score = 61.7 bits (143), Expect = 2e-08
Identities = 42/135 (31%), Positives = 66/135 (48%), Gaps = 8/135 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDR-KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
I A D D+ ++RY + +D + F +D G+L + LD + + + + V
Sbjct: 411 ISAKDPDV-TNNSIRYSIDRSSDPGRFFYVDITTGALMTARPLDRE-----EFSWHNITV 464
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A ++NNP + V I++LD+NDN PEF FY + EN G + V A D+D
Sbjct: 465 LAMEMNNPSQVGSVPVTIKVLDVNDNAPEFP-RFYEAFVCENAKAGQLIQTVSAVDQDDP 523
Query: 337 ENGEFTYQLDDPKGA 351
NG+ Y P+ A
Sbjct: 524 RNGQHFYYSLAPEAA 538
Score = 59.7 bits (138), Expect = 8e-08
Identities = 50/185 (27%), Positives = 89/185 (48%), Gaps = 14/185 (7%)
Query: 213 LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLD--AEHNLQAN 270
L+ +H+ D D G G+ ++Y L +F++D G + + LD + A++ L+A
Sbjct: 78 LYVGKLHS-DMDRGDGS-IKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRA- 134
Query: 271 TFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMA 330
Q + P++ ++ I++ D+NDN P+F Y ++ E P G SV+QV A
Sbjct: 135 ----QALDRRTGRPMEP-ESEFIIKIQDINDNEPKFLDGPYVATVPEMSPVGTSVIQVTA 189
Query: 331 TDKDQ---GENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETN 387
TD D G + Y + + FS+D ++G + +DREA + + AK+
Sbjct: 190 TDADDPTYGNSARVVYSILQGQPYFSVDSKTGVIRTALMN-MDREAKEYYEVIIQAKDMG 248
Query: 388 PSVVG 392
+ G
Sbjct: 249 GQLGG 253
Score = 58.0 bits (134), Expect = 2e-07
Identities = 52/170 (30%), Positives = 79/170 (46%), Gaps = 16/170 (9%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D G A + Y ++ G + FS+DS G + +++D E + + +QA
Sbjct: 192 ADDPTYGNSARVVYSILQG--QPYFSVDSKTG-VIRTALMNMDREAK---EYYEVIIQAK 245
Query: 280 QLNNPLK--TAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
+ L V I L D+NDN P F Y +S++E+ P +V +V A D D+G
Sbjct: 246 DMGGQLGGLAGTTTVNITLSDVNDNPPRFPQKHYQMSVLESAPISSTVGRVFAKDLDEGI 305
Query: 338 NGEFTYQLDDPKGA----FSIDP--RSGWLTVRNQTVLDREAHSSLRMKV 381
N E Y + D GA S DP + G +TV+ L E+ S +KV
Sbjct: 306 NAEMKYTIVDGDGADAFDISTDPNFQVGIITVKKP--LSFESKKSYTLKV 353
Score = 50.8 bits (116), Expect = 4e-05
Identities = 50/186 (26%), Positives = 83/186 (44%), Gaps = 14/186 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVN----GSLFLEKELDLDAE--HNLQANT 271
+ A D D G+ A ++Y ++ G+ F + + G + ++K L +++ + L+
Sbjct: 296 VFAKDLDEGINAEMKYTIVDGDGADAFDISTDPNFQVGIITVKKPLSFESKKSYTLKVEG 355
Query: 272 FVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMAT 331
++ LN V I + D+ D P FE FY + + E++ G ++ + A
Sbjct: 356 ANPHLEMRFLNLGPFQDTTTVHISVEDV-DEPPVFEPGFYFVEVPEDVAIGTTIQIISAK 414
Query: 332 DKDQGENGEFTYQLD---DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE-TN 387
D D N Y +D DP F +D +G L LDRE S + V A E N
Sbjct: 415 DPDV-TNNSIRYSIDRSSDPGRFFYVDITTGALMTARP--LDREEFSWHNITVLAMEMNN 471
Query: 388 PSVVGT 393
PS VG+
Sbjct: 472 PSQVGS 477
Score = 48.0 bits (109), Expect = 3e-04
Identities = 35/127 (27%), Positives = 58/127 (45%), Gaps = 20/127 (15%)
Query: 1293 YILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVA 1352
YIL+ I F ID G ++ ++ DRE + Y + +A ++ R + P +
Sbjct: 96 YILSGEGAGI--VFTIDDTTGDIHAIQRLDREERAQYTLRAQALDRRTGRPME----PES 149
Query: 1353 EDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQLKGAIGHHP 1412
E +++I+D+NDN PKF +G P V +P +P G V+Q+ P
Sbjct: 150 E------------FIIKIQDINDNEPKFLDG--PYVATVPEMSPVGTSVIQVTATDADDP 195
Query: 1413 TASRTVR 1419
T + R
Sbjct: 196 TYGNSAR 202
Score = 46.4 bits (105), Expect = 8e-04
Identities = 45/148 (30%), Positives = 72/148 (48%), Gaps = 18/148 (12%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PE++ IGTTI ++A D D N IRY + S+D R+F ++ G
Sbjct: 398 VPEDVAIGTTIQIISAKDPDV-TNNSIRYSIDR---------SSDP---GRFFYVDITTG 444
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVK--DVNDHFPVFKKTWYNFNVE 1055
++ AR L E S + + A++ N + SV V +K DVND+ P F + + F E
Sbjct: 445 ALMTARPLDREEFSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAPEFPRFYEAFVCE 504
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYF 1083
A+ +++ V A D D +N Y+
Sbjct: 505 NAK-AGQLIQTVSAVDQDDPRNGQHFYY 531
Score = 40.3 bits (90), Expect = 0.052
Identities = 16/29 (55%), Positives = 21/29 (72%)
Query: 85 VYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
+ I+D+NDN P FLD PY TV E++P G
Sbjct: 153 IKIQDINDNEPKFLDGPYVATVPEMSPVG 181
Score = 38.7 bits (86), Expect = 0.16
Identities = 31/106 (29%), Positives = 43/106 (40%), Gaps = 6/106 (5%)
Query: 1049 WYNFNVEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVN 1105
W F V E +YT +GK+ + D D G + ++ Y + + F I TG +
Sbjct: 63 WNQFFVLE-EYTGTDPLYVGKLHS-DMDRG-DGSIKYILSGEGAGIVFTIDDTTGDIHAI 119
Query: 1106 GELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
LDRE +Y L A D D+NDN PKF
Sbjct: 120 QRLDREERAQYTLRAQALDRRTGRPMEPESEFIIKIQDINDNEPKF 165
Score = 33.5 bits (73), Expect = 6.0
Identities = 17/40 (42%), Positives = 25/40 (62%), Gaps = 1/40 (2%)
Query: 1182 YKATIEENAPIGTTVAKVFANDTDFIGNGNGL-ILYSLPQ 1220
Y AT+ E +P+GT+V +V A D D GN ++YS+ Q
Sbjct: 170 YVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQ 209
>AF152523-1|AAD43783.1| 808|Homo sapiens protocadherin gamma B7
short form protein protein.
Length = 808
Score = 105 bits (251), Expect = 2e-21
Identities = 118/477 (24%), Positives = 200/477 (41%), Gaps = 39/477 (8%)
Query: 432 IEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNL-YEFSMKSNAKVGTVIGKVKAVDPDLG 490
+E E ++ +V V + D ND+ P F + E S + +GT++ A DPD+
Sbjct: 106 LEAVVENPLNIFHVIVVIEDVNDHAPQFRKDEINLEISESVSLGMGTILES--AEDPDIS 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVS--VAESPI---LEGRHALFVEASDQPANP 545
N + Y L ++ K NP+ G V + + + H L + A D P
Sbjct: 164 MNSLSKYQLSPNEYFSLVE--KDNPDGGKYPELVLQKTLDRETQSAHHLVLTALDGGDPP 221
Query: 546 SERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--Q 603
+ ++ I+ + P P F Y + +V GTS+ +++ D E
Sbjct: 222 RSGTAQIRILVIDAN-----DNP--PVFSQDVYRVSLREDVPPGTSILRVKATDQDEGIN 274
Query: 604 NDVSYDLLHGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNA 662
++++Y ++ F+++ +G I L Y A ++ +LS
Sbjct: 275 SEITYSFFGVADKAQHVFSLDYTTGNILTQQPLDFEEVERYTINIEA-KDRGSLSTRCKV 333
Query: 663 TVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIAN 722
V VVD ND ++ + S + E+S + +F T NG VR ++
Sbjct: 334 IVEVVDENDNSPEIIITSLSD---QIMEDSPPGVVVALFKTRDQDSGENG--EVRCSLSR 388
Query: 723 QQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEND 782
+ + T + LDRE+ Y +T+ A ++G + +T++I D ND
Sbjct: 389 GVPFKIHSSSNNYYKLVTDEALDREQTPEYNVTIAAT-DRGKPPLSSSKTITLHITDVND 447
Query: 783 NPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKE------M 836
N PVF + Y + EN++ G I + A+D D G N Y+L E
Sbjct: 448 NAPVFGQSAYLVHVPENNQPGASIAQ---VSASDPDFGLNGRVSYSLIASDLESRTLSSY 504
Query: 837 FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +GVV F + D E+ ++L+L ARD G LS+ L +++GD NDN P
Sbjct: 505 VSVSAQSGVV-FAQRAFDHEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAP 560
Score = 103 bits (247), Expect = 5e-21
Identities = 94/329 (28%), Positives = 150/329 (45%), Gaps = 27/329 (8%)
Query: 577 PYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLS 636
P + + + G+ VG + + DVS L E + F+V+ +SG + V D +
Sbjct: 32 PIRYSIPEELAKGSVVGNLAKDLGLSVLDVSARELRVSAEKLHFSVDAQSGDLLVKDRID 91
Query: 637 RYN----RPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENS 692
R R + + A+ EN L+I + V + DVND K I + E S
Sbjct: 92 REQICKERRRCELQLEAVVENP-LNIF-HVIVVIEDVNDHAPQFRK---DEINLEISE-S 145
Query: 693 AGAAIGQIFHT------NMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDR 746
+G I + +M+S+ + ++D D E + QK LDR
Sbjct: 146 VSLGMGTILESAEDPDISMNSLSKYQLSPNEYFSLVEKDNPDGGKYPE---LVLQKTLDR 202
Query: 747 EKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEI 806
E + + + V+ + G +G Q+ I + D NDNPPVF Y + E+ GT I
Sbjct: 203 ETQSAHHL-VLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRVSLREDVPPGTSI 261
Query: 807 KMDNIIKATDADEGTNALFMYTLFG---EGKEMFDVDENTGVVKFIGDSLDREKKIMYKL 863
+KATD DEG N+ Y+ FG + + +F +D TG + LD E+ Y +
Sbjct: 262 LR---VKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGNI-LTQQPLDFEEVERYTI 317
Query: 864 SLVARDTGGLSSEAELIIMIGDENDNKPE 892
++ A+D G LS+ ++I+ + DENDN PE
Sbjct: 318 NIEAKDRGSLSTRCKVIVEVVDENDNSPE 346
Score = 78.6 bits (185), Expect = 2e-13
Identities = 51/170 (30%), Positives = 84/170 (49%), Gaps = 7/170 (4%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D+ + + +Y+L L D+ +G + E L + Q+ L + A
Sbjct: 157 AEDPDISMNSLSKYQLSPNEYFSLVEKDNPDGGKYPELVLQKTLDRETQS-AHHLVLTAL 215
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
+P ++ A++ I ++D NDN P F D Y +S+ E++P G S+L+V ATD+D+G N
Sbjct: 216 DGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRVSLREDVPPGTSILRVKATDQDEGINS 275
Query: 340 EFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
E TY D + FS+D +G + Q LD E + + AK+
Sbjct: 276 EITYSFFGVADKAQHVFSLDYTTG--NILTQQPLDFEEVERYTINIEAKD 323
Score = 72.9 bits (171), Expect = 8e-12
Identities = 69/264 (26%), Positives = 116/264 (43%), Gaps = 22/264 (8%)
Query: 897 EENSKVRIHRETKLNGTAGF---TIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKL 953
EE + I+ E K G+ I+EV +N + ++ I E+ P G +
Sbjct: 310 EEVERYTINIEAKDRGSLSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGVVVALF 369
Query: 954 NALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEF 1013
D DSG NG++R + V P K+ + + Y ++ + + R PE +
Sbjct: 370 KTRDQDSGENGEVRCSLSRGV---PFKIHSSSNNY--YKLVTDE----ALDREQTPE--Y 418
Query: 1014 RLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATD 1071
+ I+A D G L+ + ++ + + DVND+ PVF ++ Y +V E + +V A+D
Sbjct: 419 NVTIAATDRGKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVPENNQPGASIAQVSASD 478
Query: 1072 ADFGQNANLTYFIQPSDTDLP-----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
DFG N ++Y + SD + +S +GV+ D E + LT+ ARD G
Sbjct: 479 PDFGLNGRVSYSLIASDLESRTLSSYVSVSAQSGVVFAQRAFDHEQLRTFELTLQARDQG 538
Query: 1127 XXXXXXXXXXXXXXXXDVNDNSPK 1150
D NDN+P+
Sbjct: 539 -SPALSANVSLRVLVGDRNDNAPR 561
Score = 72.1 bits (169), Expect = 1e-11
Identities = 96/415 (23%), Positives = 179/415 (43%), Gaps = 35/415 (8%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I E++ +G I +A D D +N +Y+ + Y S + D + +Y
Sbjct: 142 ISESVSLGMGTILESAEDPDISMNSLSKYQLSPNEYF--SLVEKDNPDGGKY-------P 192
Query: 1000 HVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+++ ++L E++ L ++ALDGG+ + +R+ V D ND+ PVF + Y ++
Sbjct: 193 ELVLQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRVSLR 252
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTY-FIQPSD-TDLPFEISPLTGVLSVNGELDRETE 1113
E + +V ATD D G N+ +TY F +D F + TG + LD E
Sbjct: 253 EDVPPGTSILRVKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGNILTQQPLDFEEV 312
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY---AFDELLEWKHP-EADELS 1169
++Y + + A+D G D NDNSP+ D+++E P L
Sbjct: 313 ERYTINIEAKDRG---SLSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGVVVALF 369
Query: 1170 NHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL 1227
+ + ++ P I ++ + TD + Y++ +
Sbjct: 370 KTRDQDSGENGEVRCSLSRGVPFKIHSSSNNYYKLVTDEALDREQTPEYNVTIAATDR-- 427
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSLNLTEHY 1285
G P LSS+ + + + DV D + PVF Y + + EN A + VS + +
Sbjct: 428 GKPPLSSSKTITLHITDVND-----NAPVFGQSAYLVHVPENNQPGASIAQVSASDPDFG 482
Query: 1286 ENFKMRY-YILNENDTDIRRTFV-IDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
N ++ Y I ++ ++ ++V + ++G ++ R+ D E T+E+ ++A Q
Sbjct: 483 LNGRVSYSLIASDLESRTLSSYVSVSAQSGVVFAQRAFDHEQLRTFELTLQARDQ 537
Score = 65.7 bits (153), Expect = 1e-09
Identities = 52/163 (31%), Positives = 78/163 (47%), Gaps = 10/163 (6%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I TQ+PLD E+ + Y + + A+ ++G +S +V + + DENDN P +
Sbjct: 299 GNILTQQPLDFEEVERYTINIEAK-DRGSLSTR--CKVIVEVVDENDNSPEIIITSLSDQ 355
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD-SLD 854
IME+S G + + K D D G N +L G + K + D +LD
Sbjct: 356 IMEDSPPGVVVAL---FKTRDQDSGENGEVRCSL-SRGVPFKIHSSSNNYYKLVTDEALD 411
Query: 855 REKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
RE+ Y +++ A D G LSS + + I D NDN P F Q
Sbjct: 412 REQTPEYNVTIAATDRGKPPLSSSKTITLHITDVNDNAPVFGQ 454
Score = 62.5 bits (145), Expect = 1e-08
Identities = 47/172 (27%), Positives = 80/172 (46%), Gaps = 13/172 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRK--LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A DQD G+ + + Y D+ +FSLD G++ ++ LD + + + +
Sbjct: 264 VKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGNILTQQPLDFE-----EVERYTIN 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
++A + L T + +V +E++D NDN PE + + I+E+ P G V D+D
Sbjct: 319 IEAKDRGS-LST-RCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGVVVALFKTRDQDS 376
Query: 336 GENGEFTYQLDDPKGA-FSIDPRS-GWLTVRNQTVLDREAHSSLRMKVYAKE 385
GENGE L +G F I S + + LDRE + + A +
Sbjct: 377 GENGEVRCSLS--RGVPFKIHSSSNNYYKLVTDEALDREQTPEYNVTIAATD 426
Score = 60.1 bits (139), Expect = 6e-08
Identities = 61/199 (30%), Positives = 94/199 (47%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN G +I +++A D D GLNG++ Y + S L + L Y ++ + G
Sbjct: 461 VPENNQPGASIAQVSASDPDFGLNGRVSYSLIA------SDLESRTLS--SYVSVSAQSG 512
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFP--VFKKTWYNFN 1053
V R+ E F L + A D G+ L+ N+S+RV V D ND+ P ++ + +
Sbjct: 513 VVFAQRAFDHEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGS 572
Query: 1054 -----VEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSDTDLPFEISPLTGVLSVNGE 1107
V A ++ KV A DAD G NA L+Y +Q S+ L F + TG + +
Sbjct: 573 ALFDTVPRAAQPGYLVTKVVAVDADSGHNAWLSYHVVQASEPGL-FSLGLRTGEVRMVRA 631
Query: 1108 LDRETEDKYILTVVARDNG 1126
L + + L V RD G
Sbjct: 632 LGDKDSVRQRLLVAVRDGG 650
Score = 59.7 bits (138), Expect = 8e-08
Identities = 68/276 (24%), Positives = 110/276 (39%), Gaps = 15/276 (5%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRG 137
S + + + D NDN P+F Y V++ E P G + +T
Sbjct: 223 SGTAQIRILVIDANDNPPVFSQDVYRVSLREDVPPGTSILRVKATDQDEGINSEITYSFF 282
Query: 138 LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGH-FALESSHKPVLLLR-KVLD--YDAG 193
K F D T N + + + +E+ + L R KV+ D
Sbjct: 283 GVADKAQHVFSLDY-TTGNILTQQPLDFEEVERYTINIEAKDRGSLSTRCKVIVEVVDEN 341
Query: 194 DKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGATLRYELISGNDRKLFSLDSV 249
D +++I + +I ++ P + A+ DQD G +R L G K+ S S
Sbjct: 342 DNSPEIIITSLSDQIMEDSP-PGVVVALFKTRDQDSGENGEVRCSLSRGVPFKIHS--SS 398
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
N L + LD E + N + + A+ P ++ + + + D+NDN P F
Sbjct: 399 NNYYKLVTDEALDREQTPEYN---VTIAATDRGKPPLSSSKTITLHITDVNDNAPVFGQS 455
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
Y + + EN G S+ QV A+D D G NG +Y L
Sbjct: 456 AYLVHVPENNQPGASIAQVSASDPDFGLNGRVSYSL 491
Score = 53.6 bits (123), Expect = 5e-06
Identities = 48/169 (28%), Positives = 75/169 (44%), Gaps = 9/169 (5%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
A+ G + + +DRE+ R + V + I+ V + IED ND+ P F
Sbjct: 79 AQSGDLLVKDRIDREQICKERRRCELQLEAVVENPLNIFHVIVVIEDVNDHAPQFRKDEI 138
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG---VVKF 848
I E+ +G +++ A D D N+L Y L E + + D G
Sbjct: 139 NLEISESVSLGMGTILES---AEDPDISMNSLSKYQLSPNEYFSLVEKDNPDGGKYPELV 195
Query: 849 IGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+ +LDRE + + L L A D G S A++ I++ D NDN P F+Q
Sbjct: 196 LQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQ 244
Score = 50.8 bits (116), Expect = 4e-05
Identities = 77/310 (24%), Positives = 126/310 (40%), Gaps = 39/310 (12%)
Query: 77 ISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP--IGPSLTIPLTV 134
+S V V + D NDN P + T + E +P G +F G + + ++
Sbjct: 327 LSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGVVVALFKTRDQDSGENGEVRCSL 386
Query: 135 PRGLTI---------FKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR 185
RG+ +K + D+ TP +V ++ D G L SS L +
Sbjct: 387 SRGVPFKIHSSSNNYYKLVTDEALDREQTPEYNV---TIAATDRGKPPLSSSKTITLHIT 443
Query: 186 KVLDY-DAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGN--DRK 242
V D + LV + + I + A D D G+ + Y LI+ + R
Sbjct: 444 DVNDNAPVFGQSAYLVHVPENNQPGASIA---QVSASDPDFGLNGRVSYSLIASDLESRT 500
Query: 243 LFSLDSVN---GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
L S SV+ G +F ++ D + Q TF L +QA +P +A + + + D
Sbjct: 501 LSSYVSVSAQSGVVFAQRAFDHE-----QLRTFELTLQARDQGSPALSANVSLRVLVGDR 555
Query: 300 NDNLPEF---EVDFYNISIVENLPN----GFSVLQVMATDKDQGENGEFTY---QLDDPK 349
NDN P + ++ + +P G+ V +V+A D D G N +Y Q +P
Sbjct: 556 NDNAPRVLYPALGPDGSALFDTVPRAAQPGYLVTKVVAVDADSGHNAWLSYHVVQASEP- 614
Query: 350 GAFSIDPRSG 359
G FS+ R+G
Sbjct: 615 GLFSLGLRTG 624
Score = 50.4 bits (115), Expect = 5e-05
Identities = 49/162 (30%), Positives = 75/162 (46%), Gaps = 10/162 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D L V EL ++ FS+D+ +G L ++ +D + + + LQ++A
Sbjct: 51 AKDLGLSVLDVSARELRVSAEKLHFSVDAQSGDLLVKDRIDRE-QICKERRRCELQLEAV 109
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
+ NPL V IE D+ND+ P+F D N+ I E++ G + A D D N
Sbjct: 110 -VENPLNIFHVIVVIE--DVNDHAPQFRKDEINLEISESVSLGMGTILESAEDPDISMNS 166
Query: 340 EFTYQLDDPKGAFSI----DPRSG-WLTVRNQTVLDREAHSS 376
YQL P FS+ +P G + + Q LDRE S+
Sbjct: 167 LSKYQL-SPNEYFSLVEKDNPDGGKYPELVLQKTLDRETQSA 207
Score = 45.6 bits (103), Expect = 0.001
Identities = 37/125 (29%), Positives = 52/125 (41%), Gaps = 5/125 (4%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD-T 1089
V V ++DVNDH P F+K N + E+ A D D N+ Y + P++
Sbjct: 119 VIVVIEDVNDHAPQFRKDEINLEISESVSLGMGTILESAEDPDISMNSLSKYQLSPNEYF 178
Query: 1090 DLPFEISPLTG---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
L + +P G L + LDRET+ + L + A D G D ND
Sbjct: 179 SLVEKDNPDGGKYPELVLQKTLDRETQSAHHLVLTALDGG-DPPRSGTAQIRILVIDAND 237
Query: 1147 NSPKF 1151
N P F
Sbjct: 238 NPPVF 242
Score = 33.9 bits (74), Expect = 4.5
Identities = 16/41 (39%), Positives = 24/41 (58%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G +S+ ++T++I DVNDN P+F + Y V V E G
Sbjct: 428 GKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVPENNQPG 468
>AF152478-1|AAD43739.1| 807|Homo sapiens protocadherin alpha 13 short
form protein protein.
Length = 807
Score = 105 bits (251), Expect = 2e-21
Identities = 132/496 (26%), Positives = 199/496 (40%), Gaps = 84/496 (16%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
++G +F +DRE+ V ++ V + + D NDNPP+F +
Sbjct: 80 QNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVKVRDINDNPPIFPESKKR 139
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
I E+ T +D A+DAD G N+ Y L + + F +D +SL
Sbjct: 140 IIIAESRPPETRFPLDG---ASDADIGVNSALTYRL--DPNDYFTLDAQ--------NSL 186
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
++ M LSLV R T E +++ + KPE L GT
Sbjct: 187 EQ----MSSLSLVLRKTLDREEIQEHSLLLTASDGGKPE-----------------LTGT 225
Query: 914 AGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
+I + N A + Q + EN GT +IKLNA D D G NG I Y F
Sbjct: 226 VQL-LITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRP 284
Query: 974 VYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGGNLN--DNI 1029
V+ P+ + A F IN +G + L E + + +++ A+D GN+ +
Sbjct: 285 VW--PAVVYA--------FTINPNNGEIRTKGKLDFEEKKLYEISVEAVDKGNIPMAGHC 334
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
++ V V DVND+ P T + + E ++ + +D D G N +T + P
Sbjct: 335 TLLVEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTP--- 391
Query: 1090 DLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+PF+ +S S ++ LDRE+ Y L V ARD G DVND
Sbjct: 392 HVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGG-SPSLWATASVSVGVADVND 450
Query: 1147 NSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDF 1206
N+P F PE Y ++EN P G + V A D D
Sbjct: 451 NAPAF---------AQPE-----------------YTVFVKENNPPGCHIFTVSAQDAD- 483
Query: 1207 IGNGNGLILYSLPQRK 1222
N L+ YSL +R+
Sbjct: 484 -AQENALVSYSLVERR 498
Score = 91.1 bits (216), Expect = 3e-17
Identities = 134/559 (23%), Positives = 217/559 (38%), Gaps = 73/559 (13%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +VEV + D NDN P+F P + + + T A D D+G
Sbjct: 105 HLEVIVDRPLQVFHVEVKVRDINDNPPIF-PESKKRIIIAESRPPETRFPLDGASDADIG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR---HALFVEASDQPANPSE 547
N + Y L T+ + + + V + H+L + ASD
Sbjct: 164 VNSALTYRLDPNDYFTLDAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELT 223
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVS 607
L + ++V + P+F + Y+ V N GT V I++N + +
Sbjct: 224 GTVQLLITILDVN-------DNAPEFYQSVYKVTVLENAFNGTLV--IKLNATDPDDGTN 274
Query: 608 YDLLHGYEEGV------PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTN 661
D+++ + V F + +G I L + +Y+ A+ + N+ + +
Sbjct: 275 GDIVYSFRRPVWPAVVYAFTINPNNGEIRTKGKLDFEEKKLYEISVEAV-DKGNIPMAGH 333
Query: 662 AT--VHVVDVNDERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRF 718
T V V+DVND V + PI +E++ +AI I ++S G V
Sbjct: 334 CTLLVEVLDVNDNAPEVTITSLSLPI----REDTQPSAI--IALISVSDRDSGSNGQVTC 387
Query: 719 LIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIE 778
+ ++ LDRE Y + V A + G S V++ +
Sbjct: 388 TLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTAR-DGGSPSLWATASVSVGVA 446
Query: 779 DENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEG- 833
D NDN P F Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 447 DVNDNAPAFAQPEYTVFVKENNPPGCHI---FTVSAQDADAQENALVSYSLVERRVGERA 503
Query: 834 -KEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNK 890
V +G V + LD E+ + + + ARD+G L S L + + DENDN
Sbjct: 504 LSSYVSVHAESGKV-YALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNA 562
Query: 891 PEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTI 950
P T G+AG T+ E L+P ++ G +
Sbjct: 563 PAL-------------LTPGAGSAGGTVSE------------------LMPRSVGAGHVV 591
Query: 951 IKLNALDLDSGLNGQIRYE 969
K+ A+D DSG N + YE
Sbjct: 592 AKVRAVDADSGYNAWLSYE 610
Score = 78.2 bits (184), Expect = 2e-13
Identities = 61/176 (34%), Positives = 88/176 (50%), Gaps = 22/176 (12%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A D D+GV + L Y L ND F+LD+ N SL L K LD + +Q ++
Sbjct: 157 ASDADIGVNSALTYRL-DPND--YFTLDAQNSLEQMSSLSLVLRKTLDRE---EIQEHSL 210
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
+L AS P T ++ I +LD+NDN PEF Y ++++EN NG V+++ ATD
Sbjct: 211 LLT--ASDGGKPELTGTVQLLITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATD 268
Query: 333 KDQGENGEFTYQLDDPKG-----AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
D G NG+ Y P AF+I+P +G +R + LD E + V A
Sbjct: 269 PDDGTNGDIVYSFRRPVWPAVVYAFTINPNNG--EIRTKGKLDFEEKKLYEISVEA 322
Score = 56.0 bits (129), Expect = 1e-06
Identities = 71/336 (21%), Positives = 133/336 (39%), Gaps = 25/336 (7%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFI------------FLIAPIGPSLTI 130
V V + D+NDN PIF ++ + + E P + + L + P+
Sbjct: 119 VEVKVRDINDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYF 178
Query: 131 PLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDY 190
L L + R + H +++ +D G L + V LL +LD
Sbjct: 179 TLDAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGT---VQLLITILDV 235
Query: 191 DAGDKEF-QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL---ISGNDRKLFSL 246
+ EF Q V + ++A D D G + Y + F++
Sbjct: 236 NDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTI 295
Query: 247 DSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF 306
+ NG + + +LD + + + + V+A N + +E+LD+NDN PE
Sbjct: 296 NPNNGEIRTKGKLDFE-----EKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEV 350
Query: 307 EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQ 366
+ ++ I E+ + + +D+D G NG+ T L + + ++
Sbjct: 351 TITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLVLD 410
Query: 367 TVLDREAHSSLRMKVYAKE-TNPSVVGTFADSQRIA 401
+ LDRE+ S+ + V A++ +PS+ T + S +A
Sbjct: 411 SALDRESVSAYELVVTARDGGSPSLWATASVSVGVA 446
Score = 55.2 bits (127), Expect = 2e-06
Identities = 57/200 (28%), Positives = 85/200 (42%), Gaps = 21/200 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN P G I ++A D D+ N + Y E + LS+ Y ++ G
Sbjct: 464 VKENNPPGCHIFTVSAQDADAQENALVSYSL-VERRVGERALSS-------YVSVHAESG 515
Query: 1000 HVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNF--- 1052
V + L E + +SA D G L N++++VFV D ND+ P
Sbjct: 516 KVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGSAGG 575
Query: 1053 NVEEAQYTR----RVLGKVDATDADFGQNANLTYFIQPS--DTDLPFEISPLTGVLSVNG 1106
V E V+ KV A DAD G NA L+Y +Q + +PF + TG +S
Sbjct: 576 TVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFRVGLYTGEISTTR 635
Query: 1107 ELDRETEDKYILTVVARDNG 1126
LD + L V+ +D+G
Sbjct: 636 PLDEVDAPHHRLLVLVKDHG 655
Score = 54.0 bits (124), Expect = 4e-06
Identities = 78/295 (26%), Positives = 120/295 (40%), Gaps = 40/295 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE----------LTPT-------GEK 115
G +++ + + + I DVNDN P F + Y VTV E L T G+
Sbjct: 218 GKPELTGTVQLLITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDI 277
Query: 116 AFIFLIAPIGPSLTIPLTV-PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFAL 174
+ F P+ P++ T+ P +IR + K + ++ V D G+ +
Sbjct: 278 VYSFR-RPVWPAVVYAFTINPNN----GEIRT--KGKLDFEEKKLYEISVEAVDKGNIPM 330
Query: 175 ESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGAT 230
+ H LL +VLD + E + ++ R E P I A+ D+D G
Sbjct: 331 -AGH--CTLLVEVLDVNDNAPEVTITSLSLPIR---EDTQPSAIIALISVSDRDSGSNGQ 384
Query: 231 LRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQA 290
+ L KL S SL L+ LD ++ + + L V A +P A A
Sbjct: 385 VTCTLTPHVPFKLVSTYKNYYSLVLDSALDRES-----VSAYELVVTARDGGSPSLWATA 439
Query: 291 RVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN P F Y + + EN P G + V A D D EN +Y L
Sbjct: 440 SVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSL 494
Score = 48.0 bits (109), Expect = 3e-04
Identities = 67/241 (27%), Positives = 100/241 (41%), Gaps = 23/241 (9%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
++EV N A +V I E+ I ++ D DSG NGQ+ V
Sbjct: 337 LVEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHV--- 393
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRV 1033
P KL + K Y+ + ++ +L ES + L ++A DGG+ L SV V
Sbjct: 394 PFKLVST---YKNYYSL-------VLDSALDRESVSAYELVVTARDGGSPSLWATASVSV 443
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTD 1090
V DVND+ P F + Y V+E + V A DAD +NA ++Y + + +
Sbjct: 444 GVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERA 503
Query: 1091 LPFEIS--PLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
L +S +G + LD E + V ARD+G D NDN+
Sbjct: 504 LSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDSG-VPPLGSNVTLQVFVLDENDNA 562
Query: 1149 P 1149
P
Sbjct: 563 P 563
Score = 44.0 bits (99), Expect = 0.004
Identities = 52/184 (28%), Positives = 83/184 (45%), Gaps = 17/184 (9%)
Query: 221 IDQDLGVG-ATL---RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQ 275
I QDLG+ A L + + S L ++ NG LF+ +D + A + L+
Sbjct: 48 IAQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLE 107
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
V ++ PL+ VE+++ D+NDN P F I I E+ P A+D D
Sbjct: 108 VI---VDRPLQVFH--VEVKVRDINDNPPIFPESKKRIIIAESRPPETRFPLDGASDADI 162
Query: 336 GENGEFTYQLDDPKGAFSIDPRSGW-----LTVRNQTVLDREAHSSLRMKVYAKE-TNPS 389
G N TY+L DP F++D ++ L++ + LDRE + + A + P
Sbjct: 163 GVNSALTYRL-DPNDYFTLDAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPE 221
Query: 390 VVGT 393
+ GT
Sbjct: 222 LTGT 225
Score = 43.6 bits (98), Expect = 0.006
Identities = 37/127 (29%), Positives = 56/127 (44%), Gaps = 11/127 (8%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFS------MKSNAKVGTVIGKVKAVDPDLGQN 492
L S V ++V +LD NDN P + M + G V+ KV+AVD D G N
Sbjct: 545 LGSNVTLQVFVLDENDNAPALLTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSGYN 604
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAE--SPILEGRHALFVEASD--QPANPSER 548
+ Y+LQ + + PF++ TG +S + H L V D +PA +
Sbjct: 605 AWLSYELQLAA-VGARIPFRVGLYTGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTATA 663
Query: 549 RYSLAVV 555
L++V
Sbjct: 664 TVLLSLV 670
Score = 40.7 bits (91), Expect = 0.039
Identities = 31/110 (28%), Positives = 47/110 (42%), Gaps = 7/110 (6%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++T+ DV D P F Y++ + EN ++ LN T+ +
Sbjct: 218 GKPELTGTVQLLITILDVNDNA-----PEFYQSVYKVTVLENAFNGTLVIKLNATDPDDG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
N + Y + F I+P NG + D E K YE+ V A
Sbjct: 273 TNGDIVYSFRRPVWPAVVYAFTINPNNGEIRTKGKLDFEEKKLYEISVEA 322
>AF152336-1|AAD43730.1| 929|Homo sapiens protocadherin gamma B7
protein.
Length = 929
Score = 105 bits (251), Expect = 2e-21
Identities = 118/477 (24%), Positives = 200/477 (41%), Gaps = 39/477 (8%)
Query: 432 IEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNL-YEFSMKSNAKVGTVIGKVKAVDPDLG 490
+E E ++ +V V + D ND+ P F + E S + +GT++ A DPD+
Sbjct: 106 LEAVVENPLNIFHVIVVIEDVNDHAPQFRKDEINLEISESVSLGMGTILES--AEDPDIS 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVS--VAESPI---LEGRHALFVEASDQPANP 545
N + Y L ++ K NP+ G V + + + H L + A D P
Sbjct: 164 MNSLSKYQLSPNEYFSLVE--KDNPDGGKYPELVLQKTLDRETQSAHHLVLTALDGGDPP 221
Query: 546 SERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--Q 603
+ ++ I+ + P P F Y + +V GTS+ +++ D E
Sbjct: 222 RSGTAQIRILVIDAN-----DNP--PVFSQDVYRVSLREDVPPGTSILRVKATDQDEGIN 274
Query: 604 NDVSYDLLHGYEEGVP-FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNA 662
++++Y ++ F+++ +G I L Y A ++ +LS
Sbjct: 275 SEITYSFFGVADKAQHVFSLDYTTGNILTQQPLDFEEVERYTINIEA-KDRGSLSTRCKV 333
Query: 663 TVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIAN 722
V VVD ND ++ + S + E+S + +F T NG VR ++
Sbjct: 334 IVEVVDENDNSPEIIITSLSD---QIMEDSPPGVVVALFKTRDQDSGENG--EVRCSLSR 388
Query: 723 QQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEND 782
+ + T + LDRE+ Y +T+ A ++G + +T++I D ND
Sbjct: 389 GVPFKIHSSSNNYYKLVTDEALDREQTPEYNVTIAAT-DRGKPPLSSSKTITLHITDVND 447
Query: 783 NPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKE------M 836
N PVF + Y + EN++ G I + A+D D G N Y+L E
Sbjct: 448 NAPVFGQSAYLVHVPENNQPGASIAQ---VSASDPDFGLNGRVSYSLIASDLESRTLSSY 504
Query: 837 FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +GVV F + D E+ ++L+L ARD G LS+ L +++GD NDN P
Sbjct: 505 VSVSAQSGVV-FAQRAFDHEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAP 560
Score = 103 bits (247), Expect = 5e-21
Identities = 94/329 (28%), Positives = 150/329 (45%), Gaps = 27/329 (8%)
Query: 577 PYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLS 636
P + + + G+ VG + + DVS L E + F+V+ +SG + V D +
Sbjct: 32 PIRYSIPEELAKGSVVGNLAKDLGLSVLDVSARELRVSAEKLHFSVDAQSGDLLVKDRID 91
Query: 637 RYN----RPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENS 692
R R + + A+ EN L+I + V + DVND K I + E S
Sbjct: 92 REQICKERRRCELQLEAVVENP-LNIF-HVIVVIEDVNDHAPQFRK---DEINLEISE-S 145
Query: 693 AGAAIGQIFHT------NMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQKPLDR 746
+G I + +M+S+ + ++D D E + QK LDR
Sbjct: 146 VSLGMGTILESAEDPDISMNSLSKYQLSPNEYFSLVEKDNPDGGKYPE---LVLQKTLDR 202
Query: 747 EKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEI 806
E + + + V+ + G +G Q+ I + D NDNPPVF Y + E+ GT I
Sbjct: 203 ETQSAHHL-VLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRVSLREDVPPGTSI 261
Query: 807 KMDNIIKATDADEGTNALFMYTLFG---EGKEMFDVDENTGVVKFIGDSLDREKKIMYKL 863
+KATD DEG N+ Y+ FG + + +F +D TG + LD E+ Y +
Sbjct: 262 LR---VKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGNI-LTQQPLDFEEVERYTI 317
Query: 864 SLVARDTGGLSSEAELIIMIGDENDNKPE 892
++ A+D G LS+ ++I+ + DENDN PE
Sbjct: 318 NIEAKDRGSLSTRCKVIVEVVDENDNSPE 346
Score = 78.6 bits (185), Expect = 2e-13
Identities = 51/170 (30%), Positives = 84/170 (49%), Gaps = 7/170 (4%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D+ + + +Y+L L D+ +G + E L + Q+ L + A
Sbjct: 157 AEDPDISMNSLSKYQLSPNEYFSLVEKDNPDGGKYPELVLQKTLDRETQS-AHHLVLTAL 215
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
+P ++ A++ I ++D NDN P F D Y +S+ E++P G S+L+V ATD+D+G N
Sbjct: 216 DGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRVSLREDVPPGTSILRVKATDQDEGINS 275
Query: 340 EFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
E TY D + FS+D +G + Q LD E + + AK+
Sbjct: 276 EITYSFFGVADKAQHVFSLDYTTG--NILTQQPLDFEEVERYTINIEAKD 323
Score = 72.9 bits (171), Expect = 8e-12
Identities = 69/264 (26%), Positives = 116/264 (43%), Gaps = 22/264 (8%)
Query: 897 EENSKVRIHRETKLNGTAGF---TIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKL 953
EE + I+ E K G+ I+EV +N + ++ I E+ P G +
Sbjct: 310 EEVERYTINIEAKDRGSLSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGVVVALF 369
Query: 954 NALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEF 1013
D DSG NG++R + V P K+ + + Y ++ + + R PE +
Sbjct: 370 KTRDQDSGENGEVRCSLSRGV---PFKIHSSSNNY--YKLVTDE----ALDREQTPE--Y 418
Query: 1014 RLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATD 1071
+ I+A D G L+ + ++ + + DVND+ PVF ++ Y +V E + +V A+D
Sbjct: 419 NVTIAATDRGKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVPENNQPGASIAQVSASD 478
Query: 1072 ADFGQNANLTYFIQPSDTDLP-----FEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
DFG N ++Y + SD + +S +GV+ D E + LT+ ARD G
Sbjct: 479 PDFGLNGRVSYSLIASDLESRTLSSYVSVSAQSGVVFAQRAFDHEQLRTFELTLQARDQG 538
Query: 1127 XXXXXXXXXXXXXXXXDVNDNSPK 1150
D NDN+P+
Sbjct: 539 -SPALSANVSLRVLVGDRNDNAPR 561
Score = 72.1 bits (169), Expect = 1e-11
Identities = 96/415 (23%), Positives = 179/415 (43%), Gaps = 35/415 (8%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I E++ +G I +A D D +N +Y+ + Y S + D + +Y
Sbjct: 142 ISESVSLGMGTILESAEDPDISMNSLSKYQLSPNEYF--SLVEKDNPDGGKY-------P 192
Query: 1000 HVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+++ ++L E++ L ++ALDGG+ + +R+ V D ND+ PVF + Y ++
Sbjct: 193 ELVLQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRVSLR 252
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTY-FIQPSD-TDLPFEISPLTGVLSVNGELDRETE 1113
E + +V ATD D G N+ +TY F +D F + TG + LD E
Sbjct: 253 EDVPPGTSILRVKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGNILTQQPLDFEEV 312
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY---AFDELLEWKHP-EADELS 1169
++Y + + A+D G D NDNSP+ D+++E P L
Sbjct: 313 ERYTINIEAKDRG---SLSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGVVVALF 369
Query: 1170 NHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL 1227
+ + ++ P I ++ + TD + Y++ +
Sbjct: 370 KTRDQDSGENGEVRCSLSRGVPFKIHSSSNNYYKLVTDEALDREQTPEYNVTIAATDR-- 427
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSLNLTEHY 1285
G P LSS+ + + + DV D + PVF Y + + EN A + VS + +
Sbjct: 428 GKPPLSSSKTITLHITDVND-----NAPVFGQSAYLVHVPENNQPGASIAQVSASDPDFG 482
Query: 1286 ENFKMRY-YILNENDTDIRRTFV-IDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
N ++ Y I ++ ++ ++V + ++G ++ R+ D E T+E+ ++A Q
Sbjct: 483 LNGRVSYSLIASDLESRTLSSYVSVSAQSGVVFAQRAFDHEQLRTFELTLQARDQ 537
Score = 65.7 bits (153), Expect = 1e-09
Identities = 52/163 (31%), Positives = 78/163 (47%), Gaps = 10/163 (6%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I TQ+PLD E+ + Y + + A+ ++G +S +V + + DENDN P +
Sbjct: 299 GNILTQQPLDFEEVERYTINIEAK-DRGSLSTR--CKVIVEVVDENDNSPEIIITSLSDQ 355
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD-SLD 854
IME+S G + + K D D G N +L G + K + D +LD
Sbjct: 356 IMEDSPPGVVVAL---FKTRDQDSGENGEVRCSL-SRGVPFKIHSSSNNYYKLVTDEALD 411
Query: 855 REKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
RE+ Y +++ A D G LSS + + I D NDN P F Q
Sbjct: 412 REQTPEYNVTIAATDRGKPPLSSSKTITLHITDVNDNAPVFGQ 454
Score = 62.5 bits (145), Expect = 1e-08
Identities = 47/172 (27%), Positives = 80/172 (46%), Gaps = 13/172 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRK--LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A DQD G+ + + Y D+ +FSLD G++ ++ LD + + + +
Sbjct: 264 VKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGNILTQQPLDFE-----EVERYTIN 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
++A + L T + +V +E++D NDN PE + + I+E+ P G V D+D
Sbjct: 319 IEAKDRGS-LST-RCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGVVVALFKTRDQDS 376
Query: 336 GENGEFTYQLDDPKGA-FSIDPRS-GWLTVRNQTVLDREAHSSLRMKVYAKE 385
GENGE L +G F I S + + LDRE + + A +
Sbjct: 377 GENGEVRCSLS--RGVPFKIHSSSNNYYKLVTDEALDREQTPEYNVTIAATD 426
Score = 60.1 bits (139), Expect = 6e-08
Identities = 61/199 (30%), Positives = 94/199 (47%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN G +I +++A D D GLNG++ Y + S L + L Y ++ + G
Sbjct: 461 VPENNQPGASIAQVSASDPDFGLNGRVSYSLIA------SDLESRTLS--SYVSVSAQSG 512
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFP--VFKKTWYNFN 1053
V R+ E F L + A D G+ L+ N+S+RV V D ND+ P ++ + +
Sbjct: 513 VVFAQRAFDHEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGS 572
Query: 1054 -----VEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSDTDLPFEISPLTGVLSVNGE 1107
V A ++ KV A DAD G NA L+Y +Q S+ L F + TG + +
Sbjct: 573 ALFDTVPRAAQPGYLVTKVVAVDADSGHNAWLSYHVVQASEPGL-FSLGLRTGEVRMVRA 631
Query: 1108 LDRETEDKYILTVVARDNG 1126
L + + L V RD G
Sbjct: 632 LGDKDSVRQRLLVAVRDGG 650
Score = 59.7 bits (138), Expect = 8e-08
Identities = 68/276 (24%), Positives = 110/276 (39%), Gaps = 15/276 (5%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRG 137
S + + + D NDN P+F Y V++ E P G + +T
Sbjct: 223 SGTAQIRILVIDANDNPPVFSQDVYRVSLREDVPPGTSILRVKATDQDEGINSEITYSFF 282
Query: 138 LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGH-FALESSHKPVLLLR-KVLD--YDAG 193
K F D T N + + + +E+ + L R KV+ D
Sbjct: 283 GVADKAQHVFSLDY-TTGNILTQQPLDFEEVERYTINIEAKDRGSLSTRCKVIVEVVDEN 341
Query: 194 DKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGATLRYELISGNDRKLFSLDSV 249
D +++I + +I ++ P + A+ DQD G +R L G K+ S S
Sbjct: 342 DNSPEIIITSLSDQIMEDSP-PGVVVALFKTRDQDSGENGEVRCSLSRGVPFKIHS--SS 398
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
N L + LD E + N + + A+ P ++ + + + D+NDN P F
Sbjct: 399 NNYYKLVTDEALDREQTPEYN---VTIAATDRGKPPLSSSKTITLHITDVNDNAPVFGQS 455
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
Y + + EN G S+ QV A+D D G NG +Y L
Sbjct: 456 AYLVHVPENNQPGASIAQVSASDPDFGLNGRVSYSL 491
Score = 53.6 bits (123), Expect = 5e-06
Identities = 48/169 (28%), Positives = 75/169 (44%), Gaps = 9/169 (5%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
A+ G + + +DRE+ R + V + I+ V + IED ND+ P F
Sbjct: 79 AQSGDLLVKDRIDREQICKERRRCELQLEAVVENPLNIFHVIVVIEDVNDHAPQFRKDEI 138
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF-GEGKEMFDVDENTG---VVKF 848
I E+ +G +++ A D D N+L Y L E + + D G
Sbjct: 139 NLEISESVSLGMGTILES---AEDPDISMNSLSKYQLSPNEYFSLVEKDNPDGGKYPELV 195
Query: 849 IGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+ +LDRE + + L L A D G S A++ I++ D NDN P F+Q
Sbjct: 196 LQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQ 244
Score = 50.8 bits (116), Expect = 4e-05
Identities = 77/310 (24%), Positives = 126/310 (40%), Gaps = 39/310 (12%)
Query: 77 ISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP--IGPSLTIPLTV 134
+S V V + D NDN P + T + E +P G +F G + + ++
Sbjct: 327 LSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGVVVALFKTRDQDSGENGEVRCSL 386
Query: 135 PRGLTI---------FKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR 185
RG+ +K + D+ TP +V ++ D G L SS L +
Sbjct: 387 SRGVPFKIHSSSNNYYKLVTDEALDREQTPEYNV---TIAATDRGKPPLSSSKTITLHIT 443
Query: 186 KVLDY-DAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGN--DRK 242
V D + LV + + I + A D D G+ + Y LI+ + R
Sbjct: 444 DVNDNAPVFGQSAYLVHVPENNQPGASIA---QVSASDPDFGLNGRVSYSLIASDLESRT 500
Query: 243 LFSLDSVN---GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
L S SV+ G +F ++ D + Q TF L +QA +P +A + + + D
Sbjct: 501 LSSYVSVSAQSGVVFAQRAFDHE-----QLRTFELTLQARDQGSPALSANVSLRVLVGDR 555
Query: 300 NDNLPEF---EVDFYNISIVENLPN----GFSVLQVMATDKDQGENGEFTY---QLDDPK 349
NDN P + ++ + +P G+ V +V+A D D G N +Y Q +P
Sbjct: 556 NDNAPRVLYPALGPDGSALFDTVPRAAQPGYLVTKVVAVDADSGHNAWLSYHVVQASEP- 614
Query: 350 GAFSIDPRSG 359
G FS+ R+G
Sbjct: 615 GLFSLGLRTG 624
Score = 50.4 bits (115), Expect = 5e-05
Identities = 49/162 (30%), Positives = 75/162 (46%), Gaps = 10/162 (6%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D L V EL ++ FS+D+ +G L ++ +D + + + LQ++A
Sbjct: 51 AKDLGLSVLDVSARELRVSAEKLHFSVDAQSGDLLVKDRIDRE-QICKERRRCELQLEAV 109
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
+ NPL V IE D+ND+ P+F D N+ I E++ G + A D D N
Sbjct: 110 -VENPLNIFHVIVVIE--DVNDHAPQFRKDEINLEISESVSLGMGTILESAEDPDISMNS 166
Query: 340 EFTYQLDDPKGAFSI----DPRSG-WLTVRNQTVLDREAHSS 376
YQL P FS+ +P G + + Q LDRE S+
Sbjct: 167 LSKYQL-SPNEYFSLVEKDNPDGGKYPELVLQKTLDRETQSA 207
Score = 45.6 bits (103), Expect = 0.001
Identities = 37/125 (29%), Positives = 52/125 (41%), Gaps = 5/125 (4%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD-T 1089
V V ++DVNDH P F+K N + E+ A D D N+ Y + P++
Sbjct: 119 VIVVIEDVNDHAPQFRKDEINLEISESVSLGMGTILESAEDPDISMNSLSKYQLSPNEYF 178
Query: 1090 DLPFEISPLTG---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
L + +P G L + LDRET+ + L + A D G D ND
Sbjct: 179 SLVEKDNPDGGKYPELVLQKTLDRETQSAHHLVLTALDGG-DPPRSGTAQIRILVIDAND 237
Query: 1147 NSPKF 1151
N P F
Sbjct: 238 NPPVF 242
Score = 33.9 bits (74), Expect = 4.5
Identities = 16/41 (39%), Positives = 24/41 (58%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTG 113
G +S+ ++T++I DVNDN P+F + Y V V E G
Sbjct: 428 GKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVPENNQPG 468
>AF152309-1|AAD43703.1| 950|Homo sapiens protocadherin alpha 13
protein.
Length = 950
Score = 105 bits (251), Expect = 2e-21
Identities = 132/496 (26%), Positives = 199/496 (40%), Gaps = 84/496 (16%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
++G +F +DRE+ V ++ V + + D NDNPP+F +
Sbjct: 80 QNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVKVRDINDNPPIFPESKKR 139
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
I E+ T +D A+DAD G N+ Y L + + F +D +SL
Sbjct: 140 IIIAESRPPETRFPLDG---ASDADIGVNSALTYRL--DPNDYFTLDAQ--------NSL 186
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
++ M LSLV R T E +++ + KPE L GT
Sbjct: 187 EQ----MSSLSLVLRKTLDREEIQEHSLLLTASDGGKPE-----------------LTGT 225
Query: 914 AGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
+I + N A + Q + EN GT +IKLNA D D G NG I Y F
Sbjct: 226 VQL-LITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRP 284
Query: 974 VYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGGNLN--DNI 1029
V+ P+ + A F IN +G + L E + + +++ A+D GN+ +
Sbjct: 285 VW--PAVVYA--------FTINPNNGEIRTKGKLDFEEKKLYEISVEAVDKGNIPMAGHC 334
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
++ V V DVND+ P T + + E ++ + +D D G N +T + P
Sbjct: 335 TLLVEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTP--- 391
Query: 1090 DLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+PF+ +S S ++ LDRE+ Y L V ARD G DVND
Sbjct: 392 HVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGG-SPSLWATASVSVGVADVND 450
Query: 1147 NSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDF 1206
N+P F PE Y ++EN P G + V A D D
Sbjct: 451 NAPAF---------AQPE-----------------YTVFVKENNPPGCHIFTVSAQDAD- 483
Query: 1207 IGNGNGLILYSLPQRK 1222
N L+ YSL +R+
Sbjct: 484 -AQENALVSYSLVERR 498
Score = 91.1 bits (216), Expect = 3e-17
Identities = 134/559 (23%), Positives = 217/559 (38%), Gaps = 73/559 (13%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +VEV + D NDN P+F P + + + T A D D+G
Sbjct: 105 HLEVIVDRPLQVFHVEVKVRDINDNPPIF-PESKKRIIIAESRPPETRFPLDGASDADIG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR---HALFVEASDQPANPSE 547
N + Y L T+ + + + V + H+L + ASD
Sbjct: 164 VNSALTYRLDPNDYFTLDAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELT 223
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVS 607
L + ++V + P+F + Y+ V N GT V I++N + +
Sbjct: 224 GTVQLLITILDVN-------DNAPEFYQSVYKVTVLENAFNGTLV--IKLNATDPDDGTN 274
Query: 608 YDLLHGYEEGV------PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTN 661
D+++ + V F + +G I L + +Y+ A+ + N+ + +
Sbjct: 275 GDIVYSFRRPVWPAVVYAFTINPNNGEIRTKGKLDFEEKKLYEISVEAV-DKGNIPMAGH 333
Query: 662 AT--VHVVDVNDERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRF 718
T V V+DVND V + PI +E++ +AI I ++S G V
Sbjct: 334 CTLLVEVLDVNDNAPEVTITSLSLPI----REDTQPSAI--IALISVSDRDSGSNGQVTC 387
Query: 719 LIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIE 778
+ ++ LDRE Y + V A + G S V++ +
Sbjct: 388 TLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTAR-DGGSPSLWATASVSVGVA 446
Query: 779 DENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEG- 833
D NDN P F Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 447 DVNDNAPAFAQPEYTVFVKENNPPGCHI---FTVSAQDADAQENALVSYSLVERRVGERA 503
Query: 834 -KEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNK 890
V +G V + LD E+ + + + ARD+G L S L + + DENDN
Sbjct: 504 LSSYVSVHAESGKV-YALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNA 562
Query: 891 PEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTI 950
P T G+AG T+ E L+P ++ G +
Sbjct: 563 PAL-------------LTPGAGSAGGTVSE------------------LMPRSVGAGHVV 591
Query: 951 IKLNALDLDSGLNGQIRYE 969
K+ A+D DSG N + YE
Sbjct: 592 AKVRAVDADSGYNAWLSYE 610
Score = 78.2 bits (184), Expect = 2e-13
Identities = 61/176 (34%), Positives = 88/176 (50%), Gaps = 22/176 (12%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A D D+GV + L Y L ND F+LD+ N SL L K LD + +Q ++
Sbjct: 157 ASDADIGVNSALTYRL-DPND--YFTLDAQNSLEQMSSLSLVLRKTLDRE---EIQEHSL 210
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
+L AS P T ++ I +LD+NDN PEF Y ++++EN NG V+++ ATD
Sbjct: 211 LLT--ASDGGKPELTGTVQLLITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATD 268
Query: 333 KDQGENGEFTYQLDDPKG-----AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
D G NG+ Y P AF+I+P +G +R + LD E + V A
Sbjct: 269 PDDGTNGDIVYSFRRPVWPAVVYAFTINPNNG--EIRTKGKLDFEEKKLYEISVEA 322
Score = 56.0 bits (129), Expect = 1e-06
Identities = 71/336 (21%), Positives = 133/336 (39%), Gaps = 25/336 (7%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFI------------FLIAPIGPSLTI 130
V V + D+NDN PIF ++ + + E P + + L + P+
Sbjct: 119 VEVKVRDINDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYF 178
Query: 131 PLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDY 190
L L + R + H +++ +D G L + V LL +LD
Sbjct: 179 TLDAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGT---VQLLITILDV 235
Query: 191 DAGDKEF-QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL---ISGNDRKLFSL 246
+ EF Q V + ++A D D G + Y + F++
Sbjct: 236 NDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTI 295
Query: 247 DSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF 306
+ NG + + +LD + + + + V+A N + +E+LD+NDN PE
Sbjct: 296 NPNNGEIRTKGKLDFE-----EKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEV 350
Query: 307 EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQ 366
+ ++ I E+ + + +D+D G NG+ T L + + ++
Sbjct: 351 TITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLVLD 410
Query: 367 TVLDREAHSSLRMKVYAKE-TNPSVVGTFADSQRIA 401
+ LDRE+ S+ + V A++ +PS+ T + S +A
Sbjct: 411 SALDRESVSAYELVVTARDGGSPSLWATASVSVGVA 446
Score = 55.2 bits (127), Expect = 2e-06
Identities = 57/200 (28%), Positives = 85/200 (42%), Gaps = 21/200 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN P G I ++A D D+ N + Y E + LS+ Y ++ G
Sbjct: 464 VKENNPPGCHIFTVSAQDADAQENALVSYSL-VERRVGERALSS-------YVSVHAESG 515
Query: 1000 HVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNF--- 1052
V + L E + +SA D G L N++++VFV D ND+ P
Sbjct: 516 KVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGSAGG 575
Query: 1053 NVEEAQYTR----RVLGKVDATDADFGQNANLTYFIQPS--DTDLPFEISPLTGVLSVNG 1106
V E V+ KV A DAD G NA L+Y +Q + +PF + TG +S
Sbjct: 576 TVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFRVGLYTGEISTTR 635
Query: 1107 ELDRETEDKYILTVVARDNG 1126
LD + L V+ +D+G
Sbjct: 636 PLDEVDAPHHRLLVLVKDHG 655
Score = 54.0 bits (124), Expect = 4e-06
Identities = 78/295 (26%), Positives = 120/295 (40%), Gaps = 40/295 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE----------LTPT-------GEK 115
G +++ + + + I DVNDN P F + Y VTV E L T G+
Sbjct: 218 GKPELTGTVQLLITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDI 277
Query: 116 AFIFLIAPIGPSLTIPLTV-PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFAL 174
+ F P+ P++ T+ P +IR + K + ++ V D G+ +
Sbjct: 278 VYSFR-RPVWPAVVYAFTINPNN----GEIRT--KGKLDFEEKKLYEISVEAVDKGNIPM 330
Query: 175 ESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGAT 230
+ H LL +VLD + E + ++ R E P I A+ D+D G
Sbjct: 331 -AGH--CTLLVEVLDVNDNAPEVTITSLSLPIR---EDTQPSAIIALISVSDRDSGSNGQ 384
Query: 231 LRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQA 290
+ L KL S SL L+ LD ++ + + L V A +P A A
Sbjct: 385 VTCTLTPHVPFKLVSTYKNYYSLVLDSALDRES-----VSAYELVVTARDGGSPSLWATA 439
Query: 291 RVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN P F Y + + EN P G + V A D D EN +Y L
Sbjct: 440 SVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSL 494
Score = 48.0 bits (109), Expect = 3e-04
Identities = 67/241 (27%), Positives = 100/241 (41%), Gaps = 23/241 (9%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
++EV N A +V I E+ I ++ D DSG NGQ+ V
Sbjct: 337 LVEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHV--- 393
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRV 1033
P KL + K Y+ + ++ +L ES + L ++A DGG+ L SV V
Sbjct: 394 PFKLVST---YKNYYSL-------VLDSALDRESVSAYELVVTARDGGSPSLWATASVSV 443
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTD 1090
V DVND+ P F + Y V+E + V A DAD +NA ++Y + + +
Sbjct: 444 GVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERA 503
Query: 1091 LPFEIS--PLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
L +S +G + LD E + V ARD+G D NDN+
Sbjct: 504 LSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDSG-VPPLGSNVTLQVFVLDENDNA 562
Query: 1149 P 1149
P
Sbjct: 563 P 563
Score = 44.0 bits (99), Expect = 0.004
Identities = 52/184 (28%), Positives = 83/184 (45%), Gaps = 17/184 (9%)
Query: 221 IDQDLGVG-ATL---RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQ 275
I QDLG+ A L + + S L ++ NG LF+ +D + A + L+
Sbjct: 48 IAQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLE 107
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
V ++ PL+ VE+++ D+NDN P F I I E+ P A+D D
Sbjct: 108 VI---VDRPLQVFH--VEVKVRDINDNPPIFPESKKRIIIAESRPPETRFPLDGASDADI 162
Query: 336 GENGEFTYQLDDPKGAFSIDPRSGW-----LTVRNQTVLDREAHSSLRMKVYAKE-TNPS 389
G N TY+L DP F++D ++ L++ + LDRE + + A + P
Sbjct: 163 GVNSALTYRL-DPNDYFTLDAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPE 221
Query: 390 VVGT 393
+ GT
Sbjct: 222 LTGT 225
Score = 43.6 bits (98), Expect = 0.006
Identities = 37/127 (29%), Positives = 56/127 (44%), Gaps = 11/127 (8%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFS------MKSNAKVGTVIGKVKAVDPDLGQN 492
L S V ++V +LD NDN P + M + G V+ KV+AVD D G N
Sbjct: 545 LGSNVTLQVFVLDENDNAPALLTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSGYN 604
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAE--SPILEGRHALFVEASD--QPANPSER 548
+ Y+LQ + + PF++ TG +S + H L V D +PA +
Sbjct: 605 AWLSYELQLAA-VGARIPFRVGLYTGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTATA 663
Query: 549 RYSLAVV 555
L++V
Sbjct: 664 TVLLSLV 670
Score = 40.7 bits (91), Expect = 0.039
Identities = 31/110 (28%), Positives = 47/110 (42%), Gaps = 7/110 (6%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++T+ DV D P F Y++ + EN ++ LN T+ +
Sbjct: 218 GKPELTGTVQLLITILDVNDNA-----PEFYQSVYKVTVLENAFNGTLVIKLNATDPDDG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
N + Y + F I+P NG + D E K YE+ V A
Sbjct: 273 TNGDIVYSFRRPVWPAVVYAFTINPNNGEIRTKGKLDFEEKKLYEISVEA 322
>AC005609-1|AAC34314.1| 807|Homo sapiens KIAA0345-like 1 protein.
Length = 807
Score = 105 bits (251), Expect = 2e-21
Identities = 132/496 (26%), Positives = 199/496 (40%), Gaps = 84/496 (16%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
++G +F +DRE+ V ++ V + + D NDNPP+F +
Sbjct: 80 QNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVKVRDINDNPPIFPESKKR 139
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
I E+ T +D A+DAD G N+ Y L + + F +D +SL
Sbjct: 140 IIIAESRPPETRFPLDG---ASDADIGVNSALTYRL--DPNDYFTLDAQ--------NSL 186
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
++ M LSLV R T E +++ + KPE L GT
Sbjct: 187 EQ----MSSLSLVLRKTLDREEIQEHSLLLTASDGGKPE-----------------LTGT 225
Query: 914 AGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
+I + N A + Q + EN GT +IKLNA D D G NG I Y F
Sbjct: 226 VQL-LITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRP 284
Query: 974 VYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGGNLN--DNI 1029
V+ P+ + A F IN +G + L E + + +++ A+D GN+ +
Sbjct: 285 VW--PAVVYA--------FTINPNNGEIRTKGKLDFEEKKLYEISVEAVDKGNIPMAGHC 334
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
++ V V DVND+ P T + + E ++ + +D D G N +T + P
Sbjct: 335 TLLVEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTP--- 391
Query: 1090 DLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+PF+ +S S ++ LDRE+ Y L V ARD G DVND
Sbjct: 392 HVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGG-SPSLWATASVSVGVADVND 450
Query: 1147 NSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDF 1206
N+P F PE Y ++EN P G + V A D D
Sbjct: 451 NAPAF---------AQPE-----------------YTVFVKENNPPGCHIFTVSAQDAD- 483
Query: 1207 IGNGNGLILYSLPQRK 1222
N L+ YSL +R+
Sbjct: 484 -AQENALVSYSLVERR 498
Score = 91.1 bits (216), Expect = 3e-17
Identities = 134/559 (23%), Positives = 217/559 (38%), Gaps = 73/559 (13%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +VEV + D NDN P+F P + + + T A D D+G
Sbjct: 105 HLEVIVDRPLQVFHVEVKVRDINDNPPIF-PESKKRIIIAESRPPETRFPLDGASDADIG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR---HALFVEASDQPANPSE 547
N + Y L T+ + + + V + H+L + ASD
Sbjct: 164 VNSALTYRLDPNDYFTLDAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELT 223
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVS 607
L + ++V + P+F + Y+ V N GT V I++N + +
Sbjct: 224 GTVQLLITILDVN-------DNAPEFYQSVYKVTVLENAFNGTLV--IKLNATDPDDGTN 274
Query: 608 YDLLHGYEEGV------PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTN 661
D+++ + V F + +G I L + +Y+ A+ + N+ + +
Sbjct: 275 GDIVYSFRRPVWPAVVYAFTINPNNGEIRTKGKLDFEEKKLYEISVEAV-DKGNIPMAGH 333
Query: 662 AT--VHVVDVNDERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRF 718
T V V+DVND V + PI +E++ +AI I ++S G V
Sbjct: 334 CTLLVEVLDVNDNAPEVTITSLSLPI----REDTQPSAI--IALISVSDRDSGSNGQVTC 387
Query: 719 LIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIE 778
+ ++ LDRE Y + V A + G S V++ +
Sbjct: 388 TLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTAR-DGGSPSLWATASVSVGVA 446
Query: 779 DENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEG- 833
D NDN P F Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 447 DVNDNAPAFAQPEYTVFVKENNPPGCHI---FTVSAQDADAQENALVSYSLVERRVGERA 503
Query: 834 -KEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNK 890
V +G V + LD E+ + + + ARD+G L S L + + DENDN
Sbjct: 504 LSSYVSVHAESGKV-YALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNA 562
Query: 891 PEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTI 950
P T G+AG T+ E L+P ++ G +
Sbjct: 563 PAL-------------LTPGAGSAGGTVSE------------------LMPRSVGAGHVV 591
Query: 951 IKLNALDLDSGLNGQIRYE 969
K+ A+D DSG N + YE
Sbjct: 592 AKVRAVDADSGYNAWLSYE 610
Score = 78.2 bits (184), Expect = 2e-13
Identities = 61/176 (34%), Positives = 88/176 (50%), Gaps = 22/176 (12%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A D D+GV + L Y L ND F+LD+ N SL L K LD + +Q ++
Sbjct: 157 ASDADIGVNSALTYRL-DPND--YFTLDAQNSLEQMSSLSLVLRKTLDRE---EIQEHSL 210
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
+L AS P T ++ I +LD+NDN PEF Y ++++EN NG V+++ ATD
Sbjct: 211 LLT--ASDGGKPELTGTVQLLITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATD 268
Query: 333 KDQGENGEFTYQLDDPKG-----AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
D G NG+ Y P AF+I+P +G +R + LD E + V A
Sbjct: 269 PDDGTNGDIVYSFRRPVWPAVVYAFTINPNNG--EIRTKGKLDFEEKKLYEISVEA 322
Score = 56.0 bits (129), Expect = 1e-06
Identities = 71/336 (21%), Positives = 133/336 (39%), Gaps = 25/336 (7%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFI------------FLIAPIGPSLTI 130
V V + D+NDN PIF ++ + + E P + + L + P+
Sbjct: 119 VEVKVRDINDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYF 178
Query: 131 PLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDY 190
L L + R + H +++ +D G L + V LL +LD
Sbjct: 179 TLDAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGT---VQLLITILDV 235
Query: 191 DAGDKEF-QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL---ISGNDRKLFSL 246
+ EF Q V + ++A D D G + Y + F++
Sbjct: 236 NDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTI 295
Query: 247 DSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF 306
+ NG + + +LD + + + + V+A N + +E+LD+NDN PE
Sbjct: 296 NPNNGEIRTKGKLDFE-----EKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEV 350
Query: 307 EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQ 366
+ ++ I E+ + + +D+D G NG+ T L + + ++
Sbjct: 351 TITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLVLD 410
Query: 367 TVLDREAHSSLRMKVYAKE-TNPSVVGTFADSQRIA 401
+ LDRE+ S+ + V A++ +PS+ T + S +A
Sbjct: 411 SALDRESVSAYELVVTARDGGSPSLWATASVSVGVA 446
Score = 55.2 bits (127), Expect = 2e-06
Identities = 57/200 (28%), Positives = 85/200 (42%), Gaps = 21/200 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN P G I ++A D D+ N + Y E + LS+ Y ++ G
Sbjct: 464 VKENNPPGCHIFTVSAQDADAQENALVSYSL-VERRVGERALSS-------YVSVHAESG 515
Query: 1000 HVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNF--- 1052
V + L E + +SA D G L N++++VFV D ND+ P
Sbjct: 516 KVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGSAGG 575
Query: 1053 NVEEAQYTR----RVLGKVDATDADFGQNANLTYFIQPS--DTDLPFEISPLTGVLSVNG 1106
V E V+ KV A DAD G NA L+Y +Q + +PF + TG +S
Sbjct: 576 TVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFRVGLYTGEISTTR 635
Query: 1107 ELDRETEDKYILTVVARDNG 1126
LD + L V+ +D+G
Sbjct: 636 PLDEVDAPHHRLLVLVKDHG 655
Score = 54.0 bits (124), Expect = 4e-06
Identities = 78/295 (26%), Positives = 120/295 (40%), Gaps = 40/295 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE----------LTPT-------GEK 115
G +++ + + + I DVNDN P F + Y VTV E L T G+
Sbjct: 218 GKPELTGTVQLLITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDI 277
Query: 116 AFIFLIAPIGPSLTIPLTV-PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFAL 174
+ F P+ P++ T+ P +IR + K + ++ V D G+ +
Sbjct: 278 VYSFR-RPVWPAVVYAFTINPNN----GEIRT--KGKLDFEEKKLYEISVEAVDKGNIPM 330
Query: 175 ESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGAT 230
+ H LL +VLD + E + ++ R E P I A+ D+D G
Sbjct: 331 -AGH--CTLLVEVLDVNDNAPEVTITSLSLPIR---EDTQPSAIIALISVSDRDSGSNGQ 384
Query: 231 LRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQA 290
+ L KL S SL L+ LD ++ + + L V A +P A A
Sbjct: 385 VTCTLTPHVPFKLVSTYKNYYSLVLDSALDRES-----VSAYELVVTARDGGSPSLWATA 439
Query: 291 RVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN P F Y + + EN P G + V A D D EN +Y L
Sbjct: 440 SVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSL 494
Score = 48.0 bits (109), Expect = 3e-04
Identities = 67/241 (27%), Positives = 100/241 (41%), Gaps = 23/241 (9%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
++EV N A +V I E+ I ++ D DSG NGQ+ V
Sbjct: 337 LVEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHV--- 393
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRV 1033
P KL + K Y+ + ++ +L ES + L ++A DGG+ L SV V
Sbjct: 394 PFKLVST---YKNYYSL-------VLDSALDRESVSAYELVVTARDGGSPSLWATASVSV 443
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTD 1090
V DVND+ P F + Y V+E + V A DAD +NA ++Y + + +
Sbjct: 444 GVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERA 503
Query: 1091 LPFEIS--PLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
L +S +G + LD E + V ARD+G D NDN+
Sbjct: 504 LSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDSG-VPPLGSNVTLQVFVLDENDNA 562
Query: 1149 P 1149
P
Sbjct: 563 P 563
Score = 44.0 bits (99), Expect = 0.004
Identities = 52/184 (28%), Positives = 83/184 (45%), Gaps = 17/184 (9%)
Query: 221 IDQDLGVG-ATL---RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQ 275
I QDLG+ A L + + S L ++ NG LF+ +D + A + L+
Sbjct: 48 IAQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLE 107
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
V ++ PL+ VE+++ D+NDN P F I I E+ P A+D D
Sbjct: 108 VI---VDRPLQVFH--VEVKVRDINDNPPIFPESKKRIIIAESRPPETRFPLDGASDADI 162
Query: 336 GENGEFTYQLDDPKGAFSIDPRSGW-----LTVRNQTVLDREAHSSLRMKVYAKE-TNPS 389
G N TY+L DP F++D ++ L++ + LDRE + + A + P
Sbjct: 163 GVNSALTYRL-DPNDYFTLDAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPE 221
Query: 390 VVGT 393
+ GT
Sbjct: 222 LTGT 225
Score = 43.6 bits (98), Expect = 0.006
Identities = 37/127 (29%), Positives = 56/127 (44%), Gaps = 11/127 (8%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFS------MKSNAKVGTVIGKVKAVDPDLGQN 492
L S V ++V +LD NDN P + M + G V+ KV+AVD D G N
Sbjct: 545 LGSNVTLQVFVLDENDNAPALLTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSGYN 604
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAE--SPILEGRHALFVEASD--QPANPSER 548
+ Y+LQ + + PF++ TG +S + H L V D +PA +
Sbjct: 605 AWLSYELQLAA-VGARIPFRVGLYTGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTATA 663
Query: 549 RYSLAVV 555
L++V
Sbjct: 664 TVLLSLV 670
Score = 40.7 bits (91), Expect = 0.039
Identities = 31/110 (28%), Positives = 47/110 (42%), Gaps = 7/110 (6%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++T+ DV D P F Y++ + EN ++ LN T+ +
Sbjct: 218 GKPELTGTVQLLITILDVNDNA-----PEFYQSVYKVTVLENAFNGTLVIKLNATDPDDG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
N + Y + F I+P NG + D E K YE+ V A
Sbjct: 273 TNGDIVYSFRRPVWPAVVYAFTINPNNGEIRTKGKLDFEEKKLYEISVEA 322
>AB208924-1|BAD92161.1| 921|Homo sapiens protocadherin alpha 13
isoform 1 precursor variant protein.
Length = 921
Score = 105 bits (251), Expect = 2e-21
Identities = 132/496 (26%), Positives = 199/496 (40%), Gaps = 84/496 (16%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
++G +F +DRE+ V ++ V + + D NDNPP+F +
Sbjct: 97 QNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVKVRDINDNPPIFPESKKR 156
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
I E+ T +D A+DAD G N+ Y L + + F +D +SL
Sbjct: 157 IIIAESRPPETRFPLDG---ASDADIGVNSALTYRL--DPNDYFTLDAQ--------NSL 203
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
++ M LSLV R T E +++ + KPE L GT
Sbjct: 204 EQ----MSSLSLVLRKTLDREEIQEHSLLLTASDGGKPE-----------------LTGT 242
Query: 914 AGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
+I + N A + Q + EN GT +IKLNA D D G NG I Y F
Sbjct: 243 VQL-LITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRP 301
Query: 974 VYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGGNLN--DNI 1029
V+ P+ + A F IN +G + L E + + +++ A+D GN+ +
Sbjct: 302 VW--PAVVYA--------FTINPNNGEIRTKGKLDFEEKKLYEISVEAVDKGNIPMAGHC 351
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
++ V V DVND+ P T + + E ++ + +D D G N +T + P
Sbjct: 352 TLLVEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTP--- 408
Query: 1090 DLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+PF+ +S S ++ LDRE+ Y L V ARD G DVND
Sbjct: 409 HVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGG-SPSLWATASVSVGVADVND 467
Query: 1147 NSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDF 1206
N+P F PE Y ++EN P G + V A D D
Sbjct: 468 NAPAF---------AQPE-----------------YTVFVKENNPPGCHIFTVSAQDAD- 500
Query: 1207 IGNGNGLILYSLPQRK 1222
N L+ YSL +R+
Sbjct: 501 -AQENALVSYSLVERR 515
Score = 91.1 bits (216), Expect = 3e-17
Identities = 134/559 (23%), Positives = 217/559 (38%), Gaps = 73/559 (13%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +VEV + D NDN P+F P + + + T A D D+G
Sbjct: 122 HLEVIVDRPLQVFHVEVKVRDINDNPPIF-PESKKRIIIAESRPPETRFPLDGASDADIG 180
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR---HALFVEASDQPANPSE 547
N + Y L T+ + + + V + H+L + ASD
Sbjct: 181 VNSALTYRLDPNDYFTLDAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELT 240
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVS 607
L + ++V + P+F + Y+ V N GT V I++N + +
Sbjct: 241 GTVQLLITILDVN-------DNAPEFYQSVYKVTVLENAFNGTLV--IKLNATDPDDGTN 291
Query: 608 YDLLHGYEEGV------PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTN 661
D+++ + V F + +G I L + +Y+ A+ + N+ + +
Sbjct: 292 GDIVYSFRRPVWPAVVYAFTINPNNGEIRTKGKLDFEEKKLYEISVEAV-DKGNIPMAGH 350
Query: 662 AT--VHVVDVNDERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRF 718
T V V+DVND V + PI +E++ +AI I ++S G V
Sbjct: 351 CTLLVEVLDVNDNAPEVTITSLSLPI----REDTQPSAI--IALISVSDRDSGSNGQVTC 404
Query: 719 LIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIE 778
+ ++ LDRE Y + V A + G S V++ +
Sbjct: 405 TLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTAR-DGGSPSLWATASVSVGVA 463
Query: 779 DENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEG- 833
D NDN P F Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 464 DVNDNAPAFAQPEYTVFVKENNPPGCHI---FTVSAQDADAQENALVSYSLVERRVGERA 520
Query: 834 -KEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNK 890
V +G V + LD E+ + + + ARD+G L S L + + DENDN
Sbjct: 521 LSSYVSVHAESGKV-YALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNA 579
Query: 891 PEFNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTI 950
P T G+AG T+ E L+P ++ G +
Sbjct: 580 PAL-------------LTPGAGSAGGTVSE------------------LMPRSVGAGHVV 608
Query: 951 IKLNALDLDSGLNGQIRYE 969
K+ A+D DSG N + YE
Sbjct: 609 AKVRAVDADSGYNAWLSYE 627
Score = 78.2 bits (184), Expect = 2e-13
Identities = 61/176 (34%), Positives = 88/176 (50%), Gaps = 22/176 (12%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNG-------SLFLEKELDLDAEHNLQANTF 272
A D D+GV + L Y L ND F+LD+ N SL L K LD + +Q ++
Sbjct: 174 ASDADIGVNSALTYRL-DPND--YFTLDAQNSLEQMSSLSLVLRKTLDRE---EIQEHSL 227
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
+L AS P T ++ I +LD+NDN PEF Y ++++EN NG V+++ ATD
Sbjct: 228 LLT--ASDGGKPELTGTVQLLITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATD 285
Query: 333 KDQGENGEFTYQLDDPKG-----AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
D G NG+ Y P AF+I+P +G +R + LD E + V A
Sbjct: 286 PDDGTNGDIVYSFRRPVWPAVVYAFTINPNNG--EIRTKGKLDFEEKKLYEISVEA 339
Score = 56.0 bits (129), Expect = 1e-06
Identities = 71/336 (21%), Positives = 133/336 (39%), Gaps = 25/336 (7%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFI------------FLIAPIGPSLTI 130
V V + D+NDN PIF ++ + + E P + + L + P+
Sbjct: 136 VEVKVRDINDNPPIFPESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYF 195
Query: 131 PLTVPRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDY 190
L L + R + H +++ +D G L + V LL +LD
Sbjct: 196 TLDAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGT---VQLLITILDV 252
Query: 191 DAGDKEF-QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL---ISGNDRKLFSL 246
+ EF Q V + ++A D D G + Y + F++
Sbjct: 253 NDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTI 312
Query: 247 DSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF 306
+ NG + + +LD + + + + V+A N + +E+LD+NDN PE
Sbjct: 313 NPNNGEIRTKGKLDFE-----EKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEV 367
Query: 307 EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQ 366
+ ++ I E+ + + +D+D G NG+ T L + + ++
Sbjct: 368 TITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLVLD 427
Query: 367 TVLDREAHSSLRMKVYAKE-TNPSVVGTFADSQRIA 401
+ LDRE+ S+ + V A++ +PS+ T + S +A
Sbjct: 428 SALDRESVSAYELVVTARDGGSPSLWATASVSVGVA 463
Score = 55.2 bits (127), Expect = 2e-06
Identities = 57/200 (28%), Positives = 85/200 (42%), Gaps = 21/200 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN P G I ++A D D+ N + Y E + LS+ Y ++ G
Sbjct: 481 VKENNPPGCHIFTVSAQDADAQENALVSYSL-VERRVGERALSS-------YVSVHAESG 532
Query: 1000 HVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVFVKDVNDHFPVFKKTWYNF--- 1052
V + L E + +SA D G L N++++VFV D ND+ P
Sbjct: 533 KVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGSAGG 592
Query: 1053 NVEEAQYTR----RVLGKVDATDADFGQNANLTYFIQPS--DTDLPFEISPLTGVLSVNG 1106
V E V+ KV A DAD G NA L+Y +Q + +PF + TG +S
Sbjct: 593 TVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFRVGLYTGEISTTR 652
Query: 1107 ELDRETEDKYILTVVARDNG 1126
LD + L V+ +D+G
Sbjct: 653 PLDEVDAPHHRLLVLVKDHG 672
Score = 54.0 bits (124), Expect = 4e-06
Identities = 78/295 (26%), Positives = 120/295 (40%), Gaps = 40/295 (13%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE----------LTPT-------GEK 115
G +++ + + + I DVNDN P F + Y VTV E L T G+
Sbjct: 235 GKPELTGTVQLLITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDI 294
Query: 116 AFIFLIAPIGPSLTIPLTV-PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFAL 174
+ F P+ P++ T+ P +IR + K + ++ V D G+ +
Sbjct: 295 VYSFR-RPVWPAVVYAFTINPNN----GEIRT--KGKLDFEEKKLYEISVEAVDKGNIPM 347
Query: 175 ESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGAT 230
+ H LL +VLD + E + ++ R E P I A+ D+D G
Sbjct: 348 -AGH--CTLLVEVLDVNDNAPEVTITSLSLPIR---EDTQPSAIIALISVSDRDSGSNGQ 401
Query: 231 LRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQA 290
+ L KL S SL L+ LD ++ + + L V A +P A A
Sbjct: 402 VTCTLTPHVPFKLVSTYKNYYSLVLDSALDRES-----VSAYELVVTARDGGSPSLWATA 456
Query: 291 RVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
V + + D+NDN P F Y + + EN P G + V A D D EN +Y L
Sbjct: 457 SVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSL 511
Score = 48.0 bits (109), Expect = 3e-04
Identities = 67/241 (27%), Positives = 100/241 (41%), Gaps = 23/241 (9%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
++EV N A +V I E+ I ++ D DSG NGQ+ V
Sbjct: 354 LVEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHV--- 410
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRV 1033
P KL + K Y+ + ++ +L ES + L ++A DGG+ L SV V
Sbjct: 411 PFKLVST---YKNYYSL-------VLDSALDRESVSAYELVVTARDGGSPSLWATASVSV 460
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTD 1090
V DVND+ P F + Y V+E + V A DAD +NA ++Y + + +
Sbjct: 461 GVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERA 520
Query: 1091 LPFEIS--PLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
L +S +G + LD E + V ARD+G D NDN+
Sbjct: 521 LSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDSG-VPPLGSNVTLQVFVLDENDNA 579
Query: 1149 P 1149
P
Sbjct: 580 P 580
Score = 44.0 bits (99), Expect = 0.004
Identities = 52/184 (28%), Positives = 83/184 (45%), Gaps = 17/184 (9%)
Query: 221 IDQDLGVG-ATL---RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQ 275
I QDLG+ A L + + S L ++ NG LF+ +D + A + L+
Sbjct: 65 IAQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLE 124
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
V ++ PL+ VE+++ D+NDN P F I I E+ P A+D D
Sbjct: 125 VI---VDRPLQVFH--VEVKVRDINDNPPIFPESKKRIIIAESRPPETRFPLDGASDADI 179
Query: 336 GENGEFTYQLDDPKGAFSIDPRSGW-----LTVRNQTVLDREAHSSLRMKVYAKE-TNPS 389
G N TY+L DP F++D ++ L++ + LDRE + + A + P
Sbjct: 180 GVNSALTYRL-DPNDYFTLDAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPE 238
Query: 390 VVGT 393
+ GT
Sbjct: 239 LTGT 242
Score = 43.6 bits (98), Expect = 0.006
Identities = 37/127 (29%), Positives = 56/127 (44%), Gaps = 11/127 (8%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFS------MKSNAKVGTVIGKVKAVDPDLGQN 492
L S V ++V +LD NDN P + M + G V+ KV+AVD D G N
Sbjct: 562 LGSNVTLQVFVLDENDNAPALLTPGAGSAGGTVSELMPRSVGAGHVVAKVRAVDADSGYN 621
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAE--SPILEGRHALFVEASD--QPANPSER 548
+ Y+LQ + + PF++ TG +S + H L V D +PA +
Sbjct: 622 AWLSYELQLAA-VGARIPFRVGLYTGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTATA 680
Query: 549 RYSLAVV 555
L++V
Sbjct: 681 TVLLSLV 687
Score = 40.7 bits (91), Expect = 0.039
Identities = 31/110 (28%), Positives = 47/110 (42%), Gaps = 7/110 (6%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++T+ DV D P F Y++ + EN ++ LN T+ +
Sbjct: 235 GKPELTGTVQLLITILDVNDNA-----PEFYQSVYKVTVLENAFNGTLVIKLNATDPDDG 289
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
N + Y + F I+P NG + D E K YE+ V A
Sbjct: 290 TNGDIVYSFRRPVWPAVVYAFTINPNNGEIRTKGKLDFEEKKLYEISVEA 339
>BC103927-1|AAI03928.1| 810|Homo sapiens protocadherin gamma
subfamily B, 1 protein.
Length = 810
Score = 104 bits (250), Expect = 2e-21
Identities = 116/468 (24%), Positives = 212/468 (45%), Gaps = 39/468 (8%)
Query: 436 DEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMV 495
D L ++ + + DANDN PVF +Y S++ N GT + +V A D D G N +
Sbjct: 216 DPPLSGTTHIWIRVTDANDNAPVF-SQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEI 274
Query: 496 LYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLA 553
Y ++ TS F +NPNTG ++ + E R+ L VEA D + + +
Sbjct: 275 TYAF--LNSPISTSLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGVHTAHCNVQIE 332
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHG 613
+V N P++ FM + + + +GT + I+V D ++ ++
Sbjct: 333 IV------DENDNAPEV-TFMS--FSNQIPEDSDLGTVIALIKVRD---KDSGQNGMVTC 380
Query: 614 Y-EEGVPFAVEERSG---VITVVDDLSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVD 668
Y +E VPF +E S + + L+R Y+ +A + LS T+ T+H+ D
Sbjct: 381 YTQEEVPFKLESTSKNYYKLVIAGALNREQTADYNVTIIATDKGKPALSSRTSITLHISD 440
Query: 669 VNDERGVLLKGAHSPIIFHVKENS-AGAAIGQIFHTNMSSIYGNGTGNVRFLIAN--QQD 725
+ND V + ++ + HV EN+ GA+I Q+ ++ + NG + L ++ ++
Sbjct: 441 INDNAPVFHQASY---VVHVSENNPPGASIAQVSASD-PDLGPNGRVSYSILASDLEPRE 496
Query: 726 VTDDIAIA-EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
+ ++++ + G +F Q+ D E+ + +T+ A ++G + + + + + D NDN
Sbjct: 497 LLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQAR-DQGSPALSANVSLRVLVGDLNDNA 555
Query: 785 P--VFEHATYEGFIMEN--SKIGTEIKMDNIIKATDADEGTNALFMY-TLFGEGKEMFDV 839
P ++ +G + + + + + A DAD G NA Y L +F +
Sbjct: 556 PRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSL 615
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
TG V+ DR+ +L + RD G LS+ A L ++ D
Sbjct: 616 GLRTGEVRTARALGDRD-AARQRLLVAVRDGGQPPLSATATLHLIFAD 662
Score = 99 bits (238), Expect = 6e-20
Identities = 119/468 (25%), Positives = 194/468 (41%), Gaps = 32/468 (6%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E M+ +V V + D NDN P FV + + + +A G A D D+ N + L
Sbjct: 108 ENPMNVFHVVVVIQDINDNAPRFVAKGI-DLEICESALPGVKFSLDSAQDADVEGNSLKL 166
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLA 553
Y + ++++ + + V + E P+ + H L + A D P L+
Sbjct: 167 YTINPNQYFSLSTKESPDGSKYPVLLLEKPLDREHQSSHRLILTAMDGGDPP------LS 220
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLL 611
T R T N + P F Y + NV GTSV ++ D E +++Y L
Sbjct: 221 GTTHIWIRVTDAND-NAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFL 279
Query: 612 HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVND 671
+ F + +G IT L Y +V ++ + N + +VD ND
Sbjct: 280 NSPISTSLFNLNPNTGDITTNGTLDFEETSRYVL-SVEAKDGGVHTAHCNVQIEIVDEND 338
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
+ + S I +++ G I I + S G V + +
Sbjct: 339 NAPEVTFMSFSNQI--PEDSDLGTVIALIKVRDKDS---GQNGMVTCYTQEEVPFKLEST 393
Query: 732 IAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
+ L+RE+ Y +T+IA +KG + + +T++I D NDN PVF A+
Sbjct: 394 SKNYYKLVIAGALNREQTADYNVTIIAT-DKGKPALSSRTSITLHISDINDNAPVFHQAS 452
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEMF---DVDENTGV 845
Y + EN+ G I + A+D D G N Y++ E +E+ V +GV
Sbjct: 453 YVVHVSENNPPGASIAQ---VSASDPDLGPNGRVSYSILASDLEPRELLSYVSVSPQSGV 509
Query: 846 VKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V F + D E+ ++L+L ARD G LS+ L +++GD NDN P
Sbjct: 510 V-FAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAP 556
Score = 87.4 bits (207), Expect = 3e-16
Identities = 78/266 (29%), Positives = 123/266 (46%), Gaps = 26/266 (9%)
Query: 897 EENSKVRIHRETKLNG--TAGFTI-IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKL 953
EE S+ + E K G TA + IE+ +N A +V + IPE+ +GT I +
Sbjct: 306 EETSRYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDSDLGTVIALI 365
Query: 954 NALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--S 1011
D DSG NG + EV P KL + + K Y+ + ++A +L E +
Sbjct: 366 KVRDKDSGQNGMVTCYTQEEV---PFKLESTS---KNYYKL-------VIAGALNREQTA 412
Query: 1012 EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
++ + I A D G L+ S+ + + D+ND+ PVF + Y +V E + +V A
Sbjct: 413 DYNVTIIATDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSA 472
Query: 1070 TDADFGQNANLTYFIQPSDTD----LPF-EISPLTGVLSVNGELDRETEDKYILTVVARD 1124
+D D G N ++Y I SD + L + +SP +GV+ D E + LT+ ARD
Sbjct: 473 SDPDLGPNGRVSYSILASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARD 532
Query: 1125 NGXXXXXXXXXXXXXXXXDVNDNSPK 1150
G D+NDN+P+
Sbjct: 533 QG-SPALSANVSLRVLVGDLNDNAPR 557
Score = 87.0 bits (206), Expect = 5e-16
Identities = 95/350 (27%), Positives = 162/350 (46%), Gaps = 39/350 (11%)
Query: 1010 ESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKV 1067
+S RL ++A+DGG+ L+ + + V D ND+ PVF + Y +++E + +V
Sbjct: 202 QSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQENVPWGTSVLRV 261
Query: 1068 DATDADFGQNANLTY-FIQ-PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
ATD D G NA +TY F+ P T L F ++P TG ++ NG LD E +Y+L+V A+D
Sbjct: 262 MATDQDEGINAEITYAFLNSPISTSL-FNLNPNTGDITTNGTLDFEETSRYVLSVEAKDG 320
Query: 1126 GXXXXXXXXXXXXXXXXDVNDNSPK--FYAFDELLEWKHPEADELSNHNFESVMMIPVYK 1183
G D NDN+P+ F +F + PE +L + +I V
Sbjct: 321 G---VHTAHCNVQIEIVDENDNAPEVTFMSFSNQI----PEDSDLGT----VIALIKVRD 369
Query: 1184 ATIEENAPIGT-TVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL---------GLPSLS 1233
+N + T +V N L++ R+ + G P+LS
Sbjct: 370 KDSGQNGMVTCYTQEEVPFKLESTSKNYYKLVIAGALNREQTADYNVTIIATDKGKPALS 429
Query: 1234 STAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSLNLTEHYENFKMR 1291
S + + ++D+ D + PVF Y + + EN A + VS + + N ++
Sbjct: 430 SRTSITLHISDIND-----NAPVFHQASYVVHVSENNPPGASIAQVSASDPDLGPNGRVS 484
Query: 1292 YYILNENDTDIRR--TFV-IDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
Y IL +D + R ++V + P++G ++ R+ D E +E+ ++A Q
Sbjct: 485 YSIL-ASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARDQ 533
Score = 86.6 bits (205), Expect = 6e-16
Identities = 59/171 (34%), Positives = 86/171 (50%), Gaps = 13/171 (7%)
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
+ +KPLDRE + +R+ ++ + G +G + I + D NDN PVF Y +
Sbjct: 191 LLLEKPLDREHQSSHRL-ILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQ 249
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGE--GKEMFDVDENTGVVKFIGDSLDR 855
EN GT + + ATD DEG NA Y +F+++ NTG + G +LD
Sbjct: 250 ENVPWGTSVLR---VMATDQDEGINAEITYAFLNSPISTSLFNLNPNTGDITTNG-TLDF 305
Query: 856 EKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEF------NQIEENS 900
E+ Y LS+ A+D G ++ + I I DENDN PE NQI E+S
Sbjct: 306 EETSRYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDS 356
Score = 77.4 bits (182), Expect = 4e-13
Identities = 58/218 (26%), Positives = 101/218 (46%), Gaps = 21/218 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN+P GT+++++ A D D G+N +I Y F + S +S F +N G
Sbjct: 248 LQENVPWGTSVLRVMATDQDEGINAEITYAFLN------SPISTS------LFNLNPNTG 295
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ +L E S + L++ A DGG + +V++ + D ND+ P ++ + E
Sbjct: 296 DITTNGTLDFEETSRYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPED 355
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
V+ + D D GQN +T + Q ++PF++ + L + G L+RE
Sbjct: 356 SDLGTVIALIKVRDKDSGQNGMVTCYTQ---EEVPFKLESTSKNYYKLVIAGALNREQTA 412
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY 1152
Y +T++A D G D+NDN+P F+
Sbjct: 413 DYNVTIIATDKG-KPALSSRTSITLHISDINDNAPVFH 449
Score = 77.0 bits (181), Expect = 5e-13
Identities = 60/170 (35%), Positives = 89/170 (52%), Gaps = 12/170 (7%)
Query: 223 QDLGV-GATLRYELISGNDR-KLFSLDSVNGSLF--LEKELDLDAEHNLQANTFVLQVQA 278
QD V G +L+ I+ N L + +S +GS + L E LD EH ++ L + A
Sbjct: 155 QDADVEGNSLKLYTINPNQYFSLSTKESPDGSKYPVLLLEKPLDREHQ---SSHRLILTA 211
Query: 279 SQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGEN 338
+P + + I + D NDN P F + Y +S+ EN+P G SVL+VMATD+D+G N
Sbjct: 212 MDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGIN 271
Query: 339 GEFTYQ-LDDP--KGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
E TY L+ P F+++P +G +T LD E S + V AK+
Sbjct: 272 AEITYAFLNSPISTSLFNLNPNTGDITTNG--TLDFEETSRYVLSVEAKD 319
Score = 68.5 bits (160), Expect = 2e-10
Identities = 67/245 (27%), Positives = 107/245 (43%), Gaps = 18/245 (7%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
E G + +DREK ++ EF + ++ V + I+D NDN P F +
Sbjct: 77 ESGDLLVNGRIDREKICGRKLECALEFETVAENPMNVFHVVVVIQDINDNAPRFVAKGID 136
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----I 849
I E++ G + +D+ A DAD N+L +YT+ E+ K+ +
Sbjct: 137 LEICESALPGVKFSLDS---AQDADVEGNSLKLYTINPNQYFSLSTKESPDGSKYPVLLL 193
Query: 850 GDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRE 907
LDRE + ++L L A D G LS + I + D NDN P F+Q E +V +
Sbjct: 194 EKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQ--EVYRVSLQE- 250
Query: 908 TKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIR 967
N G +++ V ++ ++ FL N PI T++ LN D NG +
Sbjct: 251 ---NVPWGTSVLRVMATDQDEGINAEITYAFL---NSPISTSLFNLNPNTGDITTNGTLD 304
Query: 968 YEFNS 972
+E S
Sbjct: 305 FEETS 309
Score = 67.3 bits (157), Expect = 4e-10
Identities = 55/164 (33%), Positives = 80/164 (48%), Gaps = 12/164 (7%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I T LD E+ Y ++V E G + A V I I DENDN P ++
Sbjct: 295 GDITTNGTLDFEETSRYVLSV--EAKDGGVHTAHC-NVQIEIVDENDNAPEVTFMSFSNQ 351
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENT-GVVKF-IGDSL 853
I E+S +GT I +IK D D G N M T + + + F ++ + K I +L
Sbjct: 352 IPEDSDLGTVIA---LIKVRDKDSGQNG--MVTCYTQEEVPFKLESTSKNYYKLVIAGAL 406
Query: 854 DREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ 895
+RE+ Y ++++A D G LSS + + I D NDN P F+Q
Sbjct: 407 NREQTADYNVTIIATDKGKPALSSRTSITLHISDINDNAPVFHQ 450
Score = 59.7 bits (138), Expect = 8e-08
Identities = 38/126 (30%), Positives = 62/126 (49%), Gaps = 8/126 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGN-DRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A DQD G+ A + Y ++ LF+L+ G + LD + + + +VL V
Sbjct: 261 VMATDQDEGINAEITYAFLNSPISTSLFNLNPNTGDITTNGTLDFE-----ETSRYVLSV 315
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+A + + TA V+IE++D NDN PE ++ I E+ G + + DKD G
Sbjct: 316 EAK--DGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDSDLGTVIALIKVRDKDSG 373
Query: 337 ENGEFT 342
+NG T
Sbjct: 374 QNGMVT 379
Score = 59.7 bits (138), Expect = 8e-08
Identities = 60/199 (30%), Positives = 91/199 (45%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN P G +I +++A D D G NG++ Y + P LS Y ++ + G
Sbjct: 457 VSENNPPGASIAQVSASDPDLGPNGRVSYSILASDLEPRELLS--------YVSVSPQSG 508
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFP--VFKKTWYNFN 1053
V R+ E F L + A D G+ L+ N+S+RV V D+ND+ P ++ + +
Sbjct: 509 VVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGS 568
Query: 1054 -----VEEAQYTRRVLGKVDATDADFGQNANLTYFI-QPSDTDLPFEISPLTGVLSVNGE 1107
V A ++ KV A DAD G NA L+Y + Q S+ L F + TG +
Sbjct: 569 ALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGL-FSLGLRTGEVRTARA 627
Query: 1108 LDRETEDKYILTVVARDNG 1126
L + L V RD G
Sbjct: 628 LGDRDAARQRLLVAVRDGG 646
Score = 59.3 bits (137), Expect = 1e-07
Identities = 71/335 (21%), Positives = 134/335 (40%), Gaps = 27/335 (8%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L + G +S + + + D NDN P+F Y V++ E P G +
Sbjct: 209 LTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDE 268
Query: 127 SLTIPLTV-----PRGLTIFK-DIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKP 180
+ +T P ++F + D T + + V + + ++H
Sbjct: 269 GINAEITYAFLNSPISTSLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGVHTAHCN 328
Query: 181 VLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI---DQDLGVGATLRYELIS 237
V ++ D D ++ M+ +I ++ I I D+D G +
Sbjct: 329 V----QIEIVDENDNAPEVTFMSFSNQIPEDSDLGTVIALIKVRDKDSGQNGMVTCYT-- 382
Query: 238 GNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELL 297
+ F L+S + + + K + A + Q + + + A+ P +++ + + +
Sbjct: 383 -QEEVPFKLESTSKNYY--KLVIAGALNREQTADYNVTIIATDKGKPALSSRTSITLHIS 439
Query: 298 DLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL---D-DPK---G 350
D+NDN P F Y + + EN P G S+ QV A+D D G NG +Y + D +P+
Sbjct: 440 DINDNAPVFHQASYVVHVSENNPPGASIAQVSASDPDLGPNGRVSYSILASDLEPRELLS 499
Query: 351 AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
S+ P+SG V Q D E + + + A++
Sbjct: 500 YVSVSPQSG--VVFAQRAFDHEQLRAFELTLQARD 532
Score = 49.6 bits (113), Expect = 8e-05
Identities = 50/172 (29%), Positives = 81/172 (47%), Gaps = 24/172 (13%)
Query: 218 IHAIDQDLGVGATLRYELISGN--DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTF 272
+ A D DLG + Y +++ + R+L S SV+ G +F ++ D + Q F
Sbjct: 470 VSASDPDLGPNGRVSYSILASDLEPRELLSYVSVSPQSGVVFAQRAFDHE-----QLRAF 524
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLPN----GFSV 325
L +QA +P +A + + + DLNDN P + ++ + +P G+ V
Sbjct: 525 ELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLV 584
Query: 326 LQVMATDKDQGENGEFTY---QLDDPKGAFSIDPRSGWLTVRNQTVL-DREA 373
+V+A D D G N +Y Q +P G FS+ R+G VR L DR+A
Sbjct: 585 TKVVAVDADSGHNAWLSYHVLQASEP-GLFSLGLRTG--EVRTARALGDRDA 633
Score = 49.2 bits (112), Expect = 1e-04
Identities = 62/246 (25%), Positives = 107/246 (43%), Gaps = 13/246 (5%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L S ++ + + D NDN PVF ++ Y + N G I +V A DPDLG NG V Y
Sbjct: 428 LSSRTSITLHISDINDNAPVFHQAS-YVVHVSENNPPGASIAQVSASDPDLGPNGRVSYS 486
Query: 499 LQRT--SNLTITSPFKINPNTGTVSVAESPILEGRHA--LFVEASDQPANPSERRYSLAV 554
+ + + S ++P +G V + E A L ++A DQ + SL V
Sbjct: 487 ILASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRV 546
Query: 555 VTIEVT-RGTKGNKPDI-PDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND--VSYDL 610
+ ++ + P + PD G+ V G V ++ DA ++ +SY +
Sbjct: 547 LVGDLNDNAPRVLYPALGPD--GSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHV 604
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L E G+ F++ R+G + L + VA+++ + AT+H++ +
Sbjct: 605 LQASEPGL-FSLGLRTGEVRTARALGDRDAARQRL-LVAVRDGGQPPLSATATLHLIFAD 662
Query: 671 DERGVL 676
+ VL
Sbjct: 663 SLQEVL 668
Score = 39.1 bits (87), Expect = 0.12
Identities = 47/190 (24%), Positives = 71/190 (37%), Gaps = 14/190 (7%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT- 1089
V V ++D+ND+ P F + + E+ A DAD N+ Y I P+
Sbjct: 116 VVVVIQDINDNAPRFVAKGIDLEICESALPGVKFSLDSAQDADVEGNSLKLYTINPNQYF 175
Query: 1090 DLPFEISPLTG---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
L + SP VL + LDRE + + L + A D G D ND
Sbjct: 176 SLSTKESPDGSKYPVLLLEKPLDREHQSSHRLILTAMDGG-DPPLSGTTHIWIRVTDAND 234
Query: 1147 NSPKF------YAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVF 1200
N+P F + E + W ++ E + Y N+PI T++ +
Sbjct: 235 NAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFL---NSPISTSLFNLN 291
Query: 1201 ANDTDFIGNG 1210
N D NG
Sbjct: 292 PNTGDITTNG 301
>BC103926-1|AAI03927.1| 810|Homo sapiens protocadherin gamma
subfamily B, 1 protein.
Length = 810
Score = 104 bits (250), Expect = 2e-21
Identities = 116/468 (24%), Positives = 212/468 (45%), Gaps = 39/468 (8%)
Query: 436 DEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMV 495
D L ++ + + DANDN PVF +Y S++ N GT + +V A D D G N +
Sbjct: 216 DPPLSGTTHIWIRVTDANDNAPVF-SQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEI 274
Query: 496 LYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLA 553
Y ++ TS F +NPNTG ++ + E R+ L VEA D + + +
Sbjct: 275 TYAF--LNSPISTSLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGVHTAHCNVQIE 332
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHG 613
+V N P++ FM + + + +GT + I+V D ++ ++
Sbjct: 333 IV------DENDNAPEV-TFMS--FSNQIPEDSDLGTVIALIKVRD---KDSGQNGMVTC 380
Query: 614 Y-EEGVPFAVEERSG---VITVVDDLSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVD 668
Y +E VPF +E S + + L+R Y+ +A + LS T+ T+H+ D
Sbjct: 381 YTQEEVPFKLESTSKNYYKLVIAGALNREQTADYNVTIIATDKGKPALSSRTSITLHISD 440
Query: 669 VNDERGVLLKGAHSPIIFHVKENS-AGAAIGQIFHTNMSSIYGNGTGNVRFLIAN--QQD 725
+ND V + ++ + HV EN+ GA+I Q+ ++ + NG + L ++ ++
Sbjct: 441 INDNAPVFHQASY---VVHVSENNPPGASIAQVSASD-PDLGPNGRVSYSILASDLEPRE 496
Query: 726 VTDDIAIA-EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
+ ++++ + G +F Q+ D E+ + +T+ A ++G + + + + + D NDN
Sbjct: 497 LLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQAR-DQGSPALSANVSLRVLVGDLNDNA 555
Query: 785 P--VFEHATYEGFIMEN--SKIGTEIKMDNIIKATDADEGTNALFMY-TLFGEGKEMFDV 839
P ++ +G + + + + + A DAD G NA Y L +F +
Sbjct: 556 PRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSL 615
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
TG V+ DR+ +L + RD G LS+ A L ++ D
Sbjct: 616 GLRTGEVRTARALGDRD-AARQRLLVAVRDGGQPPLSATATLHLIFAD 662
Score = 99 bits (238), Expect = 6e-20
Identities = 119/468 (25%), Positives = 194/468 (41%), Gaps = 32/468 (6%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E M+ +V V + D NDN P FV + + + +A G A D D+ N + L
Sbjct: 108 ENPMNVFHVVVVIQDINDNAPRFVAKGI-DLEICESALPGVKFSLDSAQDADVEGNSLKL 166
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLA 553
Y + ++++ + + V + E P+ + H L + A D P L+
Sbjct: 167 YTINPNQYFSLSTKESPDGSKYPVLLLEKPLDREHQSSHRLILTAMDGGDPP------LS 220
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLL 611
T R T N + P F Y + NV GTSV ++ D E +++Y L
Sbjct: 221 GTTHIWIRVTDAND-NAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFL 279
Query: 612 HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVND 671
+ F + +G IT L Y +V ++ + N + +VD ND
Sbjct: 280 NSPISTSLFNLNPNTGDITTNGTLDFEETSRYVL-SVEAKDGGVHTAHCNVQIEIVDEND 338
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
+ + S I +++ G I I + S G V + +
Sbjct: 339 NAPEVTFMSFSNQI--PEDSDLGTVIALIKVRDKDS---GQNGMVTCYTQEEVPFKLEST 393
Query: 732 IAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
+ L+RE+ Y +T+IA +KG + + +T++I D NDN PVF A+
Sbjct: 394 SKNYYKLVIAGALNREQTADYNVTIIAT-DKGKPALSSRTSITLHISDINDNAPVFHQAS 452
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEMF---DVDENTGV 845
Y + EN+ G I + A+D D G N Y++ E +E+ V +GV
Sbjct: 453 YVVHVSENNPPGASIAQ---VSASDPDLGPNGRVSYSILASDLEPRELLSYVSVSPQSGV 509
Query: 846 VKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V F + D E+ ++L+L ARD G LS+ L +++GD NDN P
Sbjct: 510 V-FAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAP 556
Score = 87.4 bits (207), Expect = 3e-16
Identities = 78/266 (29%), Positives = 123/266 (46%), Gaps = 26/266 (9%)
Query: 897 EENSKVRIHRETKLNG--TAGFTI-IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKL 953
EE S+ + E K G TA + IE+ +N A +V + IPE+ +GT I +
Sbjct: 306 EETSRYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDSDLGTVIALI 365
Query: 954 NALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--S 1011
D DSG NG + EV P KL + + K Y+ + ++A +L E +
Sbjct: 366 KVRDKDSGQNGMVTCYTQEEV---PFKLESTS---KNYYKL-------VIAGALNREQTA 412
Query: 1012 EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
++ + I A D G L+ S+ + + D+ND+ PVF + Y +V E + +V A
Sbjct: 413 DYNVTIIATDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSA 472
Query: 1070 TDADFGQNANLTYFIQPSDTD----LPF-EISPLTGVLSVNGELDRETEDKYILTVVARD 1124
+D D G N ++Y I SD + L + +SP +GV+ D E + LT+ ARD
Sbjct: 473 SDPDLGPNGRVSYSILASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARD 532
Query: 1125 NGXXXXXXXXXXXXXXXXDVNDNSPK 1150
G D+NDN+P+
Sbjct: 533 QG-SPALSANVSLRVLVGDLNDNAPR 557
Score = 87.0 bits (206), Expect = 5e-16
Identities = 95/350 (27%), Positives = 162/350 (46%), Gaps = 39/350 (11%)
Query: 1010 ESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKV 1067
+S RL ++A+DGG+ L+ + + V D ND+ PVF + Y +++E + +V
Sbjct: 202 QSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQENVPWGTSVLRV 261
Query: 1068 DATDADFGQNANLTY-FIQ-PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
ATD D G NA +TY F+ P T L F ++P TG ++ NG LD E +Y+L+V A+D
Sbjct: 262 MATDQDEGINAEITYAFLNSPISTSL-FNLNPNTGDITTNGTLDFEETSRYVLSVEAKDG 320
Query: 1126 GXXXXXXXXXXXXXXXXDVNDNSPK--FYAFDELLEWKHPEADELSNHNFESVMMIPVYK 1183
G D NDN+P+ F +F + PE +L + +I V
Sbjct: 321 G---VHTAHCNVQIEIVDENDNAPEVTFMSFSNQI----PEDSDLGT----VIALIKVRD 369
Query: 1184 ATIEENAPIGT-TVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL---------GLPSLS 1233
+N + T +V N L++ R+ + G P+LS
Sbjct: 370 KDSGQNGMVTCYTQEEVPFKLESTSKNYYKLVIAGALNREQTADYNVTIIATDKGKPALS 429
Query: 1234 STAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSLNLTEHYENFKMR 1291
S + + ++D+ D + PVF Y + + EN A + VS + + N ++
Sbjct: 430 SRTSITLHISDIND-----NAPVFHQASYVVHVSENNPPGASIAQVSASDPDLGPNGRVS 484
Query: 1292 YYILNENDTDIRR--TFV-IDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
Y IL +D + R ++V + P++G ++ R+ D E +E+ ++A Q
Sbjct: 485 YSIL-ASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARDQ 533
Score = 86.6 bits (205), Expect = 6e-16
Identities = 59/171 (34%), Positives = 86/171 (50%), Gaps = 13/171 (7%)
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
+ +KPLDRE + +R+ ++ + G +G + I + D NDN PVF Y +
Sbjct: 191 LLLEKPLDREHQSSHRL-ILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQ 249
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGE--GKEMFDVDENTGVVKFIGDSLDR 855
EN GT + + ATD DEG NA Y +F+++ NTG + G +LD
Sbjct: 250 ENVPWGTSVLR---VMATDQDEGINAEITYAFLNSPISTSLFNLNPNTGDITTNG-TLDF 305
Query: 856 EKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEF------NQIEENS 900
E+ Y LS+ A+D G ++ + I I DENDN PE NQI E+S
Sbjct: 306 EETSRYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDS 356
Score = 77.4 bits (182), Expect = 4e-13
Identities = 58/218 (26%), Positives = 101/218 (46%), Gaps = 21/218 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN+P GT+++++ A D D G+N +I Y F + S +S F +N G
Sbjct: 248 LQENVPWGTSVLRVMATDQDEGINAEITYAFLN------SPISTS------LFNLNPNTG 295
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ +L E S + L++ A DGG + +V++ + D ND+ P ++ + E
Sbjct: 296 DITTNGTLDFEETSRYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPED 355
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
V+ + D D GQN +T + Q ++PF++ + L + G L+RE
Sbjct: 356 SDLGTVIALIKVRDKDSGQNGMVTCYTQ---EEVPFKLESTSKNYYKLVIAGALNREQTA 412
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY 1152
Y +T++A D G D+NDN+P F+
Sbjct: 413 DYNVTIIATDKG-KPALSSRTSITLHISDINDNAPVFH 449
Score = 77.0 bits (181), Expect = 5e-13
Identities = 60/170 (35%), Positives = 89/170 (52%), Gaps = 12/170 (7%)
Query: 223 QDLGV-GATLRYELISGNDR-KLFSLDSVNGSLF--LEKELDLDAEHNLQANTFVLQVQA 278
QD V G +L+ I+ N L + +S +GS + L E LD EH ++ L + A
Sbjct: 155 QDADVEGNSLKLYTINPNQYFSLSTKESPDGSKYPVLLLEKPLDREHQ---SSHRLILTA 211
Query: 279 SQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGEN 338
+P + + I + D NDN P F + Y +S+ EN+P G SVL+VMATD+D+G N
Sbjct: 212 MDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGIN 271
Query: 339 GEFTYQ-LDDP--KGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
E TY L+ P F+++P +G +T LD E S + V AK+
Sbjct: 272 AEITYAFLNSPISTSLFNLNPNTGDITTNG--TLDFEETSRYVLSVEAKD 319
Score = 68.5 bits (160), Expect = 2e-10
Identities = 67/245 (27%), Positives = 107/245 (43%), Gaps = 18/245 (7%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
E G + +DREK ++ EF + ++ V + I+D NDN P F +
Sbjct: 77 ESGDLLVNGRIDREKICGRKLECALEFETVAENPMNVFHVVVVIQDINDNAPRFVAKGID 136
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----I 849
I E++ G + +D+ A DAD N+L +YT+ E+ K+ +
Sbjct: 137 LEICESALPGVKFSLDS---AQDADVEGNSLKLYTINPNQYFSLSTKESPDGSKYPVLLL 193
Query: 850 GDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRE 907
LDRE + ++L L A D G LS + I + D NDN P F+Q E +V +
Sbjct: 194 EKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQ--EVYRVSLQE- 250
Query: 908 TKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIR 967
N G +++ V ++ ++ FL N PI T++ LN D NG +
Sbjct: 251 ---NVPWGTSVLRVMATDQDEGINAEITYAFL---NSPISTSLFNLNPNTGDITTNGTLD 304
Query: 968 YEFNS 972
+E S
Sbjct: 305 FEETS 309
Score = 67.3 bits (157), Expect = 4e-10
Identities = 55/164 (33%), Positives = 80/164 (48%), Gaps = 12/164 (7%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I T LD E+ Y ++V E G + A V I I DENDN P ++
Sbjct: 295 GDITTNGTLDFEETSRYVLSV--EAKDGGVHTAHC-NVQIEIVDENDNAPEVTFMSFSNQ 351
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENT-GVVKF-IGDSL 853
I E+S +GT I +IK D D G N M T + + + F ++ + K I +L
Sbjct: 352 IPEDSDLGTVIA---LIKVRDKDSGQNG--MVTCYTQEEVPFKLESTSKNYYKLVIAGAL 406
Query: 854 DREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ 895
+RE+ Y ++++A D G LSS + + I D NDN P F+Q
Sbjct: 407 NREQTADYNVTIIATDKGKPALSSRTSITLHISDINDNAPVFHQ 450
Score = 59.7 bits (138), Expect = 8e-08
Identities = 38/126 (30%), Positives = 62/126 (49%), Gaps = 8/126 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGN-DRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A DQD G+ A + Y ++ LF+L+ G + LD + + + +VL V
Sbjct: 261 VMATDQDEGINAEITYAFLNSPISTSLFNLNPNTGDITTNGTLDFE-----ETSRYVLSV 315
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+A + + TA V+IE++D NDN PE ++ I E+ G + + DKD G
Sbjct: 316 EAK--DGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDSDLGTVIALIKVRDKDSG 373
Query: 337 ENGEFT 342
+NG T
Sbjct: 374 QNGMVT 379
Score = 59.7 bits (138), Expect = 8e-08
Identities = 60/199 (30%), Positives = 91/199 (45%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN P G +I +++A D D G NG++ Y + P LS Y ++ + G
Sbjct: 457 VSENNPPGASIAQVSASDPDLGPNGRVSYSILASDLEPRELLS--------YVSVSPQSG 508
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFP--VFKKTWYNFN 1053
V R+ E F L + A D G+ L+ N+S+RV V D+ND+ P ++ + +
Sbjct: 509 VVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGS 568
Query: 1054 -----VEEAQYTRRVLGKVDATDADFGQNANLTYFI-QPSDTDLPFEISPLTGVLSVNGE 1107
V A ++ KV A DAD G NA L+Y + Q S+ L F + TG +
Sbjct: 569 ALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGL-FSLGLRTGEVRTARA 627
Query: 1108 LDRETEDKYILTVVARDNG 1126
L + L V RD G
Sbjct: 628 LGDRDAARQRLLVAVRDGG 646
Score = 59.3 bits (137), Expect = 1e-07
Identities = 71/335 (21%), Positives = 134/335 (40%), Gaps = 27/335 (8%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L + G +S + + + D NDN P+F Y V++ E P G +
Sbjct: 209 LTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDE 268
Query: 127 SLTIPLTV-----PRGLTIFK-DIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKP 180
+ +T P ++F + D T + + V + + ++H
Sbjct: 269 GINAEITYAFLNSPISTSLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGVHTAHCN 328
Query: 181 VLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI---DQDLGVGATLRYELIS 237
V ++ D D ++ M+ +I ++ I I D+D G +
Sbjct: 329 V----QIEIVDENDNAPEVTFMSFSNQIPEDSDLGTVIALIKVRDKDSGQNGMVTCYT-- 382
Query: 238 GNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELL 297
+ F L+S + + + K + A + Q + + + A+ P +++ + + +
Sbjct: 383 -QEEVPFKLESTSKNYY--KLVIAGALNREQTADYNVTIIATDKGKPALSSRTSITLHIS 439
Query: 298 DLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL---D-DPK---G 350
D+NDN P F Y + + EN P G S+ QV A+D D G NG +Y + D +P+
Sbjct: 440 DINDNAPVFHQASYVVHVSENNPPGASIAQVSASDPDLGPNGRVSYSILASDLEPRELLS 499
Query: 351 AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
S+ P+SG V Q D E + + + A++
Sbjct: 500 YVSVSPQSG--VVFAQRAFDHEQLRAFELTLQARD 532
Score = 49.6 bits (113), Expect = 8e-05
Identities = 50/172 (29%), Positives = 81/172 (47%), Gaps = 24/172 (13%)
Query: 218 IHAIDQDLGVGATLRYELISGN--DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTF 272
+ A D DLG + Y +++ + R+L S SV+ G +F ++ D + Q F
Sbjct: 470 VSASDPDLGPNGRVSYSILASDLEPRELLSYVSVSPQSGVVFAQRAFDHE-----QLRAF 524
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLPN----GFSV 325
L +QA +P +A + + + DLNDN P + ++ + +P G+ V
Sbjct: 525 ELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLV 584
Query: 326 LQVMATDKDQGENGEFTY---QLDDPKGAFSIDPRSGWLTVRNQTVL-DREA 373
+V+A D D G N +Y Q +P G FS+ R+G VR L DR+A
Sbjct: 585 TKVVAVDADSGHNAWLSYHVLQASEP-GLFSLGLRTG--EVRTARALGDRDA 633
Score = 49.2 bits (112), Expect = 1e-04
Identities = 62/246 (25%), Positives = 107/246 (43%), Gaps = 13/246 (5%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L S ++ + + D NDN PVF ++ Y + N G I +V A DPDLG NG V Y
Sbjct: 428 LSSRTSITLHISDINDNAPVFHQAS-YVVHVSENNPPGASIAQVSASDPDLGPNGRVSYS 486
Query: 499 LQRT--SNLTITSPFKINPNTGTVSVAESPILEGRHA--LFVEASDQPANPSERRYSLAV 554
+ + + S ++P +G V + E A L ++A DQ + SL V
Sbjct: 487 ILASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRV 546
Query: 555 VTIEVT-RGTKGNKPDI-PDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND--VSYDL 610
+ ++ + P + PD G+ V G V ++ DA ++ +SY +
Sbjct: 547 LVGDLNDNAPRVLYPALGPD--GSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHV 604
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L E G+ F++ R+G + L + VA+++ + AT+H++ +
Sbjct: 605 LQASEPGL-FSLGLRTGEVRTARALGDRDAARQRL-LVAVRDGGQPPLSATATLHLIFAD 662
Query: 671 DERGVL 676
+ VL
Sbjct: 663 SLQEVL 668
Score = 39.1 bits (87), Expect = 0.12
Identities = 47/190 (24%), Positives = 71/190 (37%), Gaps = 14/190 (7%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT- 1089
V V ++D+ND+ P F + + E+ A DAD N+ Y I P+
Sbjct: 116 VVVVIQDINDNAPRFVAKGIDLEICESALPGVKFSLDSAQDADVEGNSLKLYTINPNQYF 175
Query: 1090 DLPFEISPLTG---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
L + SP VL + LDRE + + L + A D G D ND
Sbjct: 176 SLSTKESPDGSKYPVLLLEKPLDREHQSSHRLILTAMDGG-DPPLSGTTHIWIRVTDAND 234
Query: 1147 NSPKF------YAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVF 1200
N+P F + E + W ++ E + Y N+PI T++ +
Sbjct: 235 NAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFL---NSPISTSLFNLN 291
Query: 1201 ANDTDFIGNG 1210
N D NG
Sbjct: 292 PNTGDITTNG 301
>BC052973-1|AAH52973.1| 1187|Homo sapiens PCDH12 protein protein.
Length = 1187
Score = 104 bits (250), Expect = 2e-21
Identities = 130/548 (23%), Positives = 230/548 (41%), Gaps = 38/548 (6%)
Query: 440 MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
++ ++VE+ +LD ND+ P F P E + +A + T I +A+DPD G N + Y L
Sbjct: 116 LALIHVEIQVLDINDHQPRF-PKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTL 174
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILEGRHALF--VEASDQPANPSERRYSLAVVTI 557
+ + + + + + H+ F V + NP + SL V +
Sbjct: 175 SPSEHFALDVIVGPDETKHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNV 234
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGYE 615
+ + P F + + + GT + ++ D + +V + L
Sbjct: 235 ------LDSNDNSPAFAESSLALEIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMP 288
Query: 616 EGV--PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDE 672
V F+++ ++G + + L P Y+ + A N + + V+DVND
Sbjct: 289 PEVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQARDLGPNPIPAHCKVLIKVLDVNDN 348
Query: 673 -RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
+ + A P + + + I + ++ S GN G V ++ Q++
Sbjct: 349 IPSIHVTWASQPSLVS-EALPKDSFIALVMADDLDS--GNN-GLVHCWLS--QELGHFRL 402
Query: 732 IAEDGTIF---TQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+G + T LDRE+ Y +T++A+ ++G+ + Q++I I D NDN PVFE
Sbjct: 403 KRTNGNTYMLLTNATLDREQWPKYTLTLLAQ-DQGLQPLSAKKQLSIQISDINDNAPVFE 461
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG-KEMFDVDENTGVVK 847
+ YE EN+ + IKA DAD G N Y + + +D NTG V
Sbjct: 462 KSRYEVSTRENNLPSLHL---ITIKAHDADLGINGKVSYRIQDSPVAHLVAIDSNTGEVT 518
Query: 848 FIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ-IEENSKVRI 904
SL+ E+ ++ ++A D+G L+S + + + D NDN PE Q + + K +
Sbjct: 519 -AQRSLNYEEMAGFEFQVIAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASL 577
Query: 905 HRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNG 964
+N + G ++ ++ N PL + TTI+ A D DSG NG
Sbjct: 578 --SVLVNASTGHLLVPIETPNGLGPAGTDTPPLATHSSRPFLLTTIV---ARDADSGANG 632
Query: 965 QIRYEFNS 972
+ Y S
Sbjct: 633 EPLYSIRS 640
Score = 89.8 bits (213), Expect = 6e-17
Identities = 117/426 (27%), Positives = 179/426 (42%), Gaps = 53/426 (12%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
+E+G + T + LDRE+ + F+ + V I + D ND+ P F
Sbjct: 81 SEEGLLSTGRRLDREQLCRQWDPCLVSFDVLATGDLALIHVEIQVLDINDHQPRFPKGEQ 140
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDS 852
E I E++ + T I +D +A D D G N L YTL E F +D G
Sbjct: 141 ELEISESASLRTRIPLD---RALDPDTGPNTLHTYTL--SPSEHFALDVIVGP------- 188
Query: 853 LDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNG 912
D K +L +V + S +L++ D N N P+ S V+++ +
Sbjct: 189 -DETKHA--ELIVVKELDREIHSFFDLVLTAYD-NGNPPKSG----TSLVKVNVLDSNDN 240
Query: 913 TAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNS 972
+ F ++ AL++ E+ GT +IKL A D D G NG++ EF
Sbjct: 241 SPAFA------ESSLALEIQ---------EDAAPGTLLIKLTATDPDQGPNGEV--EFFL 283
Query: 973 EVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALD-GGN-LNDN 1028
++PP EV F I+ + G VI+ R L E + +++ A D G N + +
Sbjct: 284 SKHMPP--------EVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQARDLGPNPIPAH 335
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYN--FNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQP 1086
V + V DVND+ P TW + V EA + V A D D G N + ++
Sbjct: 336 CKVLIKVLDVNDNIPSIHVTWASQPSLVSEALPKDSFIALVMADDLDSGNNGLVHCWLSQ 395
Query: 1087 SDTDLPFE-ISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ + T +L N LDRE KY LT++A+D G D+N
Sbjct: 396 ELGHFRLKRTNGNTYMLLTNATLDREQWPKYTLTLLAQDQG-LQPLSAKKQLSIQISDIN 454
Query: 1146 DNSPKF 1151
DN+P F
Sbjct: 455 DNAPVF 460
Score = 72.9 bits (171), Expect = 8e-12
Identities = 124/506 (24%), Positives = 205/506 (40%), Gaps = 66/506 (13%)
Query: 997 RHGHVIVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+H +IV + L E S F L ++A D GN + V+V V D ND+ P F ++
Sbjct: 192 KHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLAL 251
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTDLPFEISPLTGVLSVNGELD 1109
++E +L K+ ATD D G N + +F+ P + F I TG + + LD
Sbjct: 252 EIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQVILRRPLD 311
Query: 1110 RETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEW-KHPE--AD 1166
E Y + V ARD G DVNDN P + + W P ++
Sbjct: 312 YEKNPAYEVDVQARDLG-PNPIPAHCKVLIKVLDVNDNIPSIH-----VTWASQPSLVSE 365
Query: 1167 ELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNG-LILYSLPQRKNQ- 1224
L +F +++M + N + +++ + NGN ++L + + Q
Sbjct: 366 ALPKDSFIALVMADDLDS--GNNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDREQW 423
Query: 1225 ---------QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVE 1275
Q+ GL LS+ L + ++D+ D + PVF YE+ EN +
Sbjct: 424 PKYTLTLLAQDQGLQPLSAKKQLSIQISDIND-----NAPVFEKSRYEVSTRENNLPSLH 478
Query: 1276 LVSLNL--TEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIV 1333
L+++ + N K+ Y I D+ + ID G + RS + E +E V
Sbjct: 479 LITIKAHDADLGINGKVSYRI---QDSPVAHLVAIDSNTGEVTAQRSLNYEEMAGFEFQV 535
Query: 1334 RAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTN---GNRPLVTA 1390
+AED + M V V V + D NDN+P+ + +
Sbjct: 536 -----------------IAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASLS 578
Query: 1391 IPTTAPFGYQVMQLKGAIGHHPTASRTVRADTDELVFFERLSLNGLTSPQATDSDIGINA 1450
+ A G+ ++ ++ G P + T T R L LT+ A D+D G N
Sbjct: 579 VLVNASTGHLLVPIETPNGLGPAGTDTPPLATHS----SRPFL--LTTIVARDADSGANG 632
Query: 1451 DIRYQILN-EQAPRFAIDPVSGTVRV 1475
+ Y I + +A F ++P +G + V
Sbjct: 633 EPLYSIRSGNEAHLFILNPHTGQLFV 658
Score = 64.9 bits (151), Expect = 2e-09
Identities = 129/540 (23%), Positives = 213/540 (39%), Gaps = 49/540 (9%)
Query: 31 HVSVILAQSIDSLVDSDSPQNVVKFRLGCDFDEGDDLVRIGA--GLNQISAYLSVTVYIE 88
H +I+ + +D + S + + G G LV++ + A+ ++ +E
Sbjct: 193 HAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALE 252
Query: 89 DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSL--TIPLTVPRGLTIFKDIRA 146
D P L T + P GE F FL + P + T + G I + R
Sbjct: 253 IQEDAAPGTLLIKLTATDPDQGPNGEVEF-FLSKHMPPEVLDTFSIDAKTGQVILR--RP 309
Query: 147 FDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGK 206
D +K P +V V D G + + H VL+ KVLD + V AS
Sbjct: 310 LDYEK--NPAYEVD---VQARDLGPNPIPA-HCKVLI--KVLDVNDNIPSIH-VTWASQP 360
Query: 207 RIHKEILFPEPIHAI--DQDLGVGATLRYELISGNDRKLFSLDSVNGSLF-LEKELDLDA 263
+ E L + A+ DL G + F L NG+ + L LD
Sbjct: 361 SLVSEALPKDSFIALVMADDLDSGNNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDR 420
Query: 264 EHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGF 323
E T L Q L PL +A+ ++ I++ D+NDN P FE Y +S EN
Sbjct: 421 EQ-WPKYTLTLLAQDQGLQ-PL-SAKKQLSIQISDINDNAPVFEKSRYEVSTRENNLPSL 477
Query: 324 SVLQVMATDKDQGENGEFTYQLDDPKGA--FSIDPRSGWLTVRNQTVLDREAHSSLRMKV 381
++ + A D D G NG+ +Y++ D A +ID +G +T Q L+ E + +V
Sbjct: 478 HLITIKAHDADLGINGKVSYRIQDSPVAHLVAIDSNTGEVTA--QRSLNYEEMAGFEFQV 535
Query: 382 YAKETNPSVVGTFADSQRIAKW-RRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLM 440
A+++ ++ + ++ W NAP E V D + + + L+
Sbjct: 536 IAEDSGQPML-----ASSVSVWVSLLDANDNAP-EVVQPVLSDGKASLSVLVNASTGHLL 589
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
+ L A + P + F + T++ + D D G NG LY ++
Sbjct: 590 VPIETPNGLGPAGTDTPPLATHSSRPFLLT------TIVAR----DADSGANGEPLYSIR 639
Query: 501 RTSNLTITSPFKINPNTGT--VSVAESPILEGRH-ALFVEASDQPANPSERRYSLAVVTI 557
+ + F +NP+TG V+V + L G L + DQ + P + R L V+ +
Sbjct: 640 SGNEAHL---FILNPHTGQLFVNVTNASSLIGSEWELEIVVEDQGSPPLQTRALLRVMFV 696
Score = 62.1 bits (144), Expect = 1e-08
Identities = 76/337 (22%), Positives = 145/337 (43%), Gaps = 37/337 (10%)
Query: 579 EFWVGSNVGIGTSVGQIRVNDAFE----QNDVSYDLLHGYEEGVPFAVEERSGVITVVDD 634
++ V V GT +G++ E Q ++ +L + +P V+ G+++
Sbjct: 33 KYQVSEEVPSGTVIGKLSQELGREERRRQAGAAFQVLQ-LPQALPIQVDSEEGLLSTGRR 91
Query: 635 LSR------YNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHV 688
L R ++ + F+ +A +L+++ + + V+D+ND + KG
Sbjct: 92 LDREQLCRQWDPCLVSFDVLA---TGDLALI-HVEIQVLDINDHQPRFPKGEQE------ 141
Query: 689 KENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLIANQQDVTDDIAIAEDGT----IFTQKP 743
E S A++ + + G + + ++ + D+ + D T + K
Sbjct: 142 LEISESASLRTRIPLDRALDPDTGPNTLHTYTLSPSEHFALDVIVGPDETKHAELIVVKE 201
Query: 744 LDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIG 803
LDRE + + V+ ++ G +G V + + D NDN P F ++ I E++ G
Sbjct: 202 LDREIHSFFDL-VLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALEIQEDAAPG 260
Query: 804 TEIKMDNIIKATDADEGTNALFMYTLF----GEGKEMFDVDENTGVVKFIGDSLDREKKI 859
T + + ATD D+G N + L E + F +D TG V + LD EK
Sbjct: 261 TLLIK---LTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQV-ILRRPLDYEKNP 316
Query: 860 MYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFN 894
Y++ + ARD G + + +++I + D NDN P +
Sbjct: 317 AYEVDVQARDLGPNPIPAHCKVLIKVLDVNDNIPSIH 353
Score = 40.3 bits (90), Expect = 0.052
Identities = 35/112 (31%), Positives = 50/112 (44%), Gaps = 7/112 (6%)
Query: 288 AQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD 347
A VEI++LD+ND+ P F + I E+ + A D D G N TY L
Sbjct: 117 ALIHVEIQVLDINDHQPRFPKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTL-S 175
Query: 348 PKGAFSIDPRSGWLTVRNQTV-----LDREAHSSLRMKVYAKET-NPSVVGT 393
P F++D G ++ + LDRE HS + + A + NP GT
Sbjct: 176 PSEHFALDVIVGPDETKHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGT 227
>BC042634-1|AAH42634.1| 1187|Homo sapiens PCDH12 protein protein.
Length = 1187
Score = 104 bits (250), Expect = 2e-21
Identities = 130/548 (23%), Positives = 230/548 (41%), Gaps = 38/548 (6%)
Query: 440 MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
++ ++VE+ +LD ND+ P F P E + +A + T I +A+DPD G N + Y L
Sbjct: 116 LALIHVEIQVLDINDHQPRF-PKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTL 174
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILEGRHALF--VEASDQPANPSERRYSLAVVTI 557
+ + + + + + H+ F V + NP + SL V +
Sbjct: 175 SPSEHFALDVIVGPDETKHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNV 234
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGYE 615
+ + P F + + + GT + ++ D + +V + L
Sbjct: 235 ------LDSNDNSPAFAESSLALEIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMP 288
Query: 616 EGV--PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDE 672
V F+++ ++G + + L P Y+ + A N + + V+DVND
Sbjct: 289 PEVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQARDLGPNPIPAHCKVLIKVLDVNDN 348
Query: 673 -RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
+ + A P + + + I + ++ S GN G V ++ Q++
Sbjct: 349 IPSIHVTWASQPSLVS-EALPKDSFIALVMADDLDS--GNN-GLVHCWLS--QELGHFRL 402
Query: 732 IAEDGTIF---TQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+G + T LDRE+ Y +T++A+ ++G+ + Q++I I D NDN PVFE
Sbjct: 403 KRTNGNTYMLLTNATLDREQWPKYTLTLLAQ-DQGLQPLSAKKQLSIQISDINDNAPVFE 461
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG-KEMFDVDENTGVVK 847
+ YE EN+ + IKA DAD G N Y + + +D NTG V
Sbjct: 462 KSRYEVSTRENNLPSLHL---ITIKAHDADLGINGKVSYRIQDSPVAHLVAIDSNTGEVT 518
Query: 848 FIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ-IEENSKVRI 904
SL+ E+ ++ ++A D+G L+S + + + D NDN PE Q + + K +
Sbjct: 519 -AQRSLNYEEMAGFEFQVIAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASL 577
Query: 905 HRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNG 964
+N + G ++ ++ N PL + TTI+ A D DSG NG
Sbjct: 578 --SVLVNASTGHLLVPIETPNGLGPAGTDTPPLATHSSRPFLLTTIV---ARDADSGANG 632
Query: 965 QIRYEFNS 972
+ Y S
Sbjct: 633 EPLYSIRS 640
Score = 89.8 bits (213), Expect = 6e-17
Identities = 117/426 (27%), Positives = 179/426 (42%), Gaps = 53/426 (12%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
+E+G + T + LDRE+ + F+ + V I + D ND+ P F
Sbjct: 81 SEEGLLSTGRRLDREQLCRQWDPCLVSFDVLATGDLALIHVEIQVLDINDHQPRFPKGEQ 140
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDS 852
E I E++ + T I +D +A D D G N L YTL E F +D G
Sbjct: 141 ELEISESASLRTRIPLD---RALDPDTGPNTLHTYTL--SPSEHFALDVIVGP------- 188
Query: 853 LDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNG 912
D K +L +V + S +L++ D N N P+ S V+++ +
Sbjct: 189 -DETKHA--ELIVVKELDREIHSFFDLVLTAYD-NGNPPKSG----TSLVKVNVLDSNDN 240
Query: 913 TAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNS 972
+ F ++ AL++ E+ GT +IKL A D D G NG++ EF
Sbjct: 241 SPAFA------ESSLALEIQ---------EDAAPGTLLIKLTATDPDQGPNGEV--EFFL 283
Query: 973 EVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALD-GGN-LNDN 1028
++PP EV F I+ + G VI+ R L E + +++ A D G N + +
Sbjct: 284 SKHMPP--------EVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQARDLGPNPIPAH 335
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYN--FNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQP 1086
V + V DVND+ P TW + V EA + V A D D G N + ++
Sbjct: 336 CKVLIKVLDVNDNIPSIHVTWASQPSLVSEALPKDSFIALVMADDLDSGNNGLVHCWLSQ 395
Query: 1087 SDTDLPFE-ISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ + T +L N LDRE KY LT++A+D G D+N
Sbjct: 396 ELGHFRLKRTNGNTYMLLTNATLDREQWPKYTLTLLAQDQG-LQPLSAKKQLSIQISDIN 454
Query: 1146 DNSPKF 1151
DN+P F
Sbjct: 455 DNAPVF 460
Score = 72.9 bits (171), Expect = 8e-12
Identities = 124/506 (24%), Positives = 205/506 (40%), Gaps = 66/506 (13%)
Query: 997 RHGHVIVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+H +IV + L E S F L ++A D GN + V+V V D ND+ P F ++
Sbjct: 192 KHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLAL 251
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTDLPFEISPLTGVLSVNGELD 1109
++E +L K+ ATD D G N + +F+ P + F I TG + + LD
Sbjct: 252 EIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQVILRRPLD 311
Query: 1110 RETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEW-KHPE--AD 1166
E Y + V ARD G DVNDN P + + W P ++
Sbjct: 312 YEKNPAYEVDVQARDLG-PNPIPAHCKVLIKVLDVNDNIPSIH-----VTWASQPSLVSE 365
Query: 1167 ELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNG-LILYSLPQRKNQ- 1224
L +F +++M + N + +++ + NGN ++L + + Q
Sbjct: 366 ALPKDSFIALVMADDLDS--GNNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDREQW 423
Query: 1225 ---------QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVE 1275
Q+ GL LS+ L + ++D+ D + PVF YE+ EN +
Sbjct: 424 PKYTLTLLAQDQGLQPLSAKKQLSIQISDIND-----NAPVFEKSRYEVSTRENNLPSLH 478
Query: 1276 LVSLNL--TEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIV 1333
L+++ + N K+ Y I D+ + ID G + RS + E +E V
Sbjct: 479 LITIKAHDADLGINGKVSYRI---QDSPVAHLVAIDSNTGEVTAQRSLNYEEMAGFEFQV 535
Query: 1334 RAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTN---GNRPLVTA 1390
+AED + M V V V + D NDN+P+ + +
Sbjct: 536 -----------------IAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASLS 578
Query: 1391 IPTTAPFGYQVMQLKGAIGHHPTASRTVRADTDELVFFERLSLNGLTSPQATDSDIGINA 1450
+ A G+ ++ ++ G P + T T R L LT+ A D+D G N
Sbjct: 579 VLVNASTGHLLVPIETPNGLGPAGTDTPPLATHS----SRPFL--LTTIVARDADSGANG 632
Query: 1451 DIRYQILN-EQAPRFAIDPVSGTVRV 1475
+ Y I + +A F ++P +G + V
Sbjct: 633 EPLYSIRSGNEAHLFILNPHTGQLFV 658
Score = 64.9 bits (151), Expect = 2e-09
Identities = 129/540 (23%), Positives = 213/540 (39%), Gaps = 49/540 (9%)
Query: 31 HVSVILAQSIDSLVDSDSPQNVVKFRLGCDFDEGDDLVRIGA--GLNQISAYLSVTVYIE 88
H +I+ + +D + S + + G G LV++ + A+ ++ +E
Sbjct: 193 HAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALE 252
Query: 89 DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSL--TIPLTVPRGLTIFKDIRA 146
D P L T + P GE F FL + P + T + G I + R
Sbjct: 253 IQEDAAPGTLLIKLTATDPDQGPNGEVEF-FLSKHMPPEVLDTFSIDAKTGQVILR--RP 309
Query: 147 FDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGK 206
D +K P +V V D G + + H VL+ KVLD + V AS
Sbjct: 310 LDYEK--NPAYEVD---VQARDLGPNPIPA-HCKVLI--KVLDVNDNIPSIH-VTWASQP 360
Query: 207 RIHKEILFPEPIHAI--DQDLGVGATLRYELISGNDRKLFSLDSVNGSLF-LEKELDLDA 263
+ E L + A+ DL G + F L NG+ + L LD
Sbjct: 361 SLVSEALPKDSFIALVMADDLDSGNNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDR 420
Query: 264 EHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGF 323
E T L Q L PL +A+ ++ I++ D+NDN P FE Y +S EN
Sbjct: 421 EQ-WPKYTLTLLAQDQGLQ-PL-SAKKQLSIQISDINDNAPVFEKSRYEVSTRENNLPSL 477
Query: 324 SVLQVMATDKDQGENGEFTYQLDDPKGA--FSIDPRSGWLTVRNQTVLDREAHSSLRMKV 381
++ + A D D G NG+ +Y++ D A +ID +G +T Q L+ E + +V
Sbjct: 478 HLITIKAHDADLGINGKVSYRIQDSPVAHLVAIDSNTGEVTA--QRSLNYEEMAGFEFQV 535
Query: 382 YAKETNPSVVGTFADSQRIAKW-RRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLM 440
A+++ ++ + ++ W NAP E V D + + + L+
Sbjct: 536 IAEDSGQPML-----ASSVSVWVSLLDANDNAP-EVVQPVLSDGKASLSVLVNASTGHLL 589
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
+ L A + P + F + T++ + D D G NG LY ++
Sbjct: 590 VPIETPNGLGPAGTDTPPLATHSSRPFLLT------TIVAR----DADSGANGEPLYSIR 639
Query: 501 RTSNLTITSPFKINPNTGT--VSVAESPILEGRH-ALFVEASDQPANPSERRYSLAVVTI 557
+ + F +NP+TG V+V + L G L + DQ + P + R L V+ +
Sbjct: 640 SGNEAHL---FILNPHTGQLFVNVTNASSLIGSEWELEIVVEDQGSPPLQTRALLRVMFV 696
Score = 62.1 bits (144), Expect = 1e-08
Identities = 76/337 (22%), Positives = 145/337 (43%), Gaps = 37/337 (10%)
Query: 579 EFWVGSNVGIGTSVGQIRVNDAFE----QNDVSYDLLHGYEEGVPFAVEERSGVITVVDD 634
++ V V GT +G++ E Q ++ +L + +P V+ G+++
Sbjct: 33 KYQVSEEVPSGTVIGKLSQELGREERRRQAGAAFQVLQ-LPQALPIQVDSEEGLLSTGRR 91
Query: 635 LSR------YNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHV 688
L R ++ + F+ +A +L+++ + + V+D+ND + KG
Sbjct: 92 LDREQLCRQWDPCLVSFDVLA---TGDLALI-HVEIQVLDINDHQPRFPKGEQE------ 141
Query: 689 KENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLIANQQDVTDDIAIAEDGT----IFTQKP 743
E S A++ + + G + + ++ + D+ + D T + K
Sbjct: 142 LEISESASLRTRIPLDRALDPDTGPNTLHTYTLSPSEHFALDVIVGPDETKHAELIVVKE 201
Query: 744 LDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIG 803
LDRE + + V+ ++ G +G V + + D NDN P F ++ I E++ G
Sbjct: 202 LDREIHSFFDL-VLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALEIQEDAAPG 260
Query: 804 TEIKMDNIIKATDADEGTNALFMYTLF----GEGKEMFDVDENTGVVKFIGDSLDREKKI 859
T + + ATD D+G N + L E + F +D TG V + LD EK
Sbjct: 261 TLLIK---LTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQV-ILRRPLDYEKNP 316
Query: 860 MYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFN 894
Y++ + ARD G + + +++I + D NDN P +
Sbjct: 317 AYEVDVQARDLGPNPIPAHCKVLIKVLDVNDNIPSIH 353
Score = 40.3 bits (90), Expect = 0.052
Identities = 35/112 (31%), Positives = 50/112 (44%), Gaps = 7/112 (6%)
Query: 288 AQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD 347
A VEI++LD+ND+ P F + I E+ + A D D G N TY L
Sbjct: 117 ALIHVEIQVLDINDHQPRFPKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTL-S 175
Query: 348 PKGAFSIDPRSGWLTVRNQTV-----LDREAHSSLRMKVYAKET-NPSVVGT 393
P F++D G ++ + LDRE HS + + A + NP GT
Sbjct: 176 PSEHFALDVIVGPDETKHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGT 227
>AK024140-1|BAB14837.1| 1187|Homo sapiens protein ( Homo sapiens
cDNA FLJ14078 fis, clone HEMBB1002044, moderately
similar to Mus musculus mRNA for vascular cadherin-2. ).
Length = 1187
Score = 104 bits (250), Expect = 2e-21
Identities = 130/548 (23%), Positives = 230/548 (41%), Gaps = 38/548 (6%)
Query: 440 MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
++ ++VE+ +LD ND+ P F P E + +A + T I +A+DPD G N + Y L
Sbjct: 116 LALIHVEIQVLDINDHQPRF-PKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTL 174
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILEGRHALF--VEASDQPANPSERRYSLAVVTI 557
+ + + + + + H+ F V + NP + SL V +
Sbjct: 175 SPSEHFALDVIVGPDETKHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNV 234
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGYE 615
+ + P F + + + GT + ++ D + +V + L
Sbjct: 235 ------LDSNDNSPAFAESSLALEIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMP 288
Query: 616 EGV--PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDE 672
V F+++ ++G + + L P Y+ + A N + + V+DVND
Sbjct: 289 PEVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQARDLGPNPIPAHCKVLIKVLDVNDN 348
Query: 673 -RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
+ + A P + + + I + ++ S GN G V ++ Q++
Sbjct: 349 IPSIHVTWASQPSLVS-EALPKDSFIALVMADDLDS--GNN-GLVHCWLS--QELGHFRL 402
Query: 732 IAEDGTIF---TQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+G + T LDRE+ Y +T++A+ ++G+ + Q++I I D NDN PVFE
Sbjct: 403 KRTNGNTYMLLTNATLDREQWPKYTLTLLAQ-DQGLQPLSAKKQLSIQISDINDNAPVFE 461
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG-KEMFDVDENTGVVK 847
+ YE EN+ + IKA DAD G N Y + + +D NTG V
Sbjct: 462 KSRYEVSTRENNLPSLHL---ITIKAHDADLGINGKVSYRIQDSPVAHLVAIDSNTGEVT 518
Query: 848 FIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ-IEENSKVRI 904
SL+ E+ ++ ++A D+G L+S + + + D NDN PE Q + + K +
Sbjct: 519 -AQRSLNYEEMAGFEFQVIAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASL 577
Query: 905 HRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNG 964
+N + G ++ ++ N PL + TTI+ A D DSG NG
Sbjct: 578 --SVLVNASTGHLLVPIETPNGLGPAGTDTPPLATHSSRPFLLTTIV---ARDADSGANG 632
Query: 965 QIRYEFNS 972
+ Y S
Sbjct: 633 EPLYSIRS 640
Score = 89.8 bits (213), Expect = 6e-17
Identities = 117/426 (27%), Positives = 179/426 (42%), Gaps = 53/426 (12%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
+E+G + T + LDRE+ + F+ + V I + D ND+ P F
Sbjct: 81 SEEGLLSTGRRLDREQLCRQWDPCLVSFDVLATGDLALIHVEIQVLDINDHQPRFPKGEQ 140
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDS 852
E I E++ + T I +D +A D D G N L YTL E F +D G
Sbjct: 141 ELEISESASLRTRIPLD---RALDPDTGPNTLHTYTL--SPSEHFALDVIVGP------- 188
Query: 853 LDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNG 912
D K +L +V + S +L++ D N N P+ S V+++ +
Sbjct: 189 -DETKHA--ELIVVKELDREIHSFFDLVLTAYD-NGNPPKSG----TSLVKVNVLDSNDN 240
Query: 913 TAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNS 972
+ F ++ AL++ E+ GT +IKL A D D G NG++ EF
Sbjct: 241 SPAFA------ESSLALEIQ---------EDAAPGTLLIKLTATDPDQGPNGEV--EFFL 283
Query: 973 EVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALD-GGN-LNDN 1028
++PP EV F I+ + G VI+ R L E + +++ A D G N + +
Sbjct: 284 SKHMPP--------EVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQARDLGPNPIPAH 335
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYN--FNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQP 1086
V + V DVND+ P TW + V EA + V A D D G N + ++
Sbjct: 336 CKVLIKVLDVNDNIPSIHVTWASQPSLVSEALPKDSFIALVMADDLDSGNNGLVHCWLSQ 395
Query: 1087 SDTDLPFE-ISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ + T +L N LDRE KY LT++A+D G D+N
Sbjct: 396 ELGHFRLKRTNGNTYMLLTNATLDREQWPKYTLTLLAQDQG-LQPLSAKKQLSIQISDIN 454
Query: 1146 DNSPKF 1151
DN+P F
Sbjct: 455 DNAPVF 460
Score = 72.9 bits (171), Expect = 8e-12
Identities = 124/506 (24%), Positives = 205/506 (40%), Gaps = 66/506 (13%)
Query: 997 RHGHVIVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+H +IV + L E S F L ++A D GN + V+V V D ND+ P F ++
Sbjct: 192 KHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLAL 251
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTDLPFEISPLTGVLSVNGELD 1109
++E +L K+ ATD D G N + +F+ P + F I TG + + LD
Sbjct: 252 EIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQVILRRPLD 311
Query: 1110 RETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEW-KHPE--AD 1166
E Y + V ARD G DVNDN P + + W P ++
Sbjct: 312 YEKNPAYEVDVQARDLG-PNPIPAHCKVLIKVLDVNDNIPSIH-----VTWASQPSLVSE 365
Query: 1167 ELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNG-LILYSLPQRKNQ- 1224
L +F +++M + N + +++ + NGN ++L + + Q
Sbjct: 366 ALPKDSFIALVMADDLDS--GNNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDREQW 423
Query: 1225 ---------QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVE 1275
Q+ GL LS+ L + ++D+ D + PVF YE+ EN +
Sbjct: 424 PKYTLTLLAQDQGLQPLSAKKQLSIQISDIND-----NAPVFEKSRYEVSTRENNLPSLH 478
Query: 1276 LVSLNL--TEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIV 1333
L+++ + N K+ Y I D+ + ID G + RS + E +E V
Sbjct: 479 LITIKAHDADLGINGKVSYRI---QDSPVAHLVAIDSNTGEVTAQRSLNYEEMAGFEFQV 535
Query: 1334 RAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTN---GNRPLVTA 1390
+AED + M V V V + D NDN+P+ + +
Sbjct: 536 -----------------IAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASLS 578
Query: 1391 IPTTAPFGYQVMQLKGAIGHHPTASRTVRADTDELVFFERLSLNGLTSPQATDSDIGINA 1450
+ A G+ ++ ++ G P + T T R L LT+ A D+D G N
Sbjct: 579 VLVNASTGHLLVPIETPNGLGPAGTDTPPLATHS----SRPFL--LTTIVARDADSGANG 632
Query: 1451 DIRYQILN-EQAPRFAIDPVSGTVRV 1475
+ Y I + +A F ++P +G + V
Sbjct: 633 EPLYSIRSGNEAHLFILNPHTGQLFV 658
Score = 64.9 bits (151), Expect = 2e-09
Identities = 129/540 (23%), Positives = 213/540 (39%), Gaps = 49/540 (9%)
Query: 31 HVSVILAQSIDSLVDSDSPQNVVKFRLGCDFDEGDDLVRIGA--GLNQISAYLSVTVYIE 88
H +I+ + +D + S + + G G LV++ + A+ ++ +E
Sbjct: 193 HAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALE 252
Query: 89 DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSL--TIPLTVPRGLTIFKDIRA 146
D P L T + P GE F FL + P + T + G I + R
Sbjct: 253 IQEDAAPGTLLIKLTATDPDQGPNGEVEF-FLSKHMPPEVLDTFSIDAKTGQVILR--RP 309
Query: 147 FDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGK 206
D +K P +V V D G + + H VL+ KVLD + V AS
Sbjct: 310 LDYEK--NPAYEVD---VQARDLGPNPIPA-HCKVLI--KVLDVNDNIPSIH-VTWASQP 360
Query: 207 RIHKEILFPEPIHAI--DQDLGVGATLRYELISGNDRKLFSLDSVNGSLF-LEKELDLDA 263
+ E L + A+ DL G + F L NG+ + L LD
Sbjct: 361 SLVSEALPKDSFIALVMADDLDSGNNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDR 420
Query: 264 EHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGF 323
E T L Q L PL +A+ ++ I++ D+NDN P FE Y +S EN
Sbjct: 421 EQ-WPKYTLTLLAQDQGLQ-PL-SAKKQLSIQISDINDNAPVFEKSRYEVSTRENNLPSL 477
Query: 324 SVLQVMATDKDQGENGEFTYQLDDPKGA--FSIDPRSGWLTVRNQTVLDREAHSSLRMKV 381
++ + A D D G NG+ +Y++ D A +ID +G +T Q L+ E + +V
Sbjct: 478 HLITIKAHDADLGINGKVSYRIQDSPVAHLVAIDSNTGEVTA--QRSLNYEEMAGFEFQV 535
Query: 382 YAKETNPSVVGTFADSQRIAKW-RRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLM 440
A+++ ++ + ++ W NAP E V D + + + L+
Sbjct: 536 IAEDSGQPML-----ASSVSVWVSLLDANDNAP-EVVQPVLSDGKASLSVLVNASTGHLL 589
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
+ L A + P + F + T++ + D D G NG LY ++
Sbjct: 590 VPIETPNGLGPAGTDTPPLATHSSRPFLLT------TIVAR----DADSGANGEPLYSIR 639
Query: 501 RTSNLTITSPFKINPNTGT--VSVAESPILEGRH-ALFVEASDQPANPSERRYSLAVVTI 557
+ + F +NP+TG V+V + L G L + DQ + P + R L V+ +
Sbjct: 640 SGNEAHL---FILNPHTGQLFVNVTNASSLIGSEWELEIVVEDQGSPPLQTRALLRVMFV 696
Score = 62.1 bits (144), Expect = 1e-08
Identities = 76/337 (22%), Positives = 145/337 (43%), Gaps = 37/337 (10%)
Query: 579 EFWVGSNVGIGTSVGQIRVNDAFE----QNDVSYDLLHGYEEGVPFAVEERSGVITVVDD 634
++ V V GT +G++ E Q ++ +L + +P V+ G+++
Sbjct: 33 KYQVSEEVPSGTVIGKLSQELGREERRRQAGAAFQVLQ-LPQALPIQVDSEEGLLSTGRR 91
Query: 635 LSR------YNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHV 688
L R ++ + F+ +A +L+++ + + V+D+ND + KG
Sbjct: 92 LDREQLCRQWDPCLVSFDVLA---TGDLALI-HVEIQVLDINDHQPRFPKGEQE------ 141
Query: 689 KENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLIANQQDVTDDIAIAEDGT----IFTQKP 743
E S A++ + + G + + ++ + D+ + D T + K
Sbjct: 142 LEISESASLRTRIPLDRALDPDTGPNTLHTYTLSPSEHFALDVIVGPDETKHAELIVVKE 201
Query: 744 LDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIG 803
LDRE + + V+ ++ G +G V + + D NDN P F ++ I E++ G
Sbjct: 202 LDREIHSFFDL-VLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALEIQEDAAPG 260
Query: 804 TEIKMDNIIKATDADEGTNALFMYTLF----GEGKEMFDVDENTGVVKFIGDSLDREKKI 859
T + + ATD D+G N + L E + F +D TG V + LD EK
Sbjct: 261 TLLIK---LTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQV-ILRRPLDYEKNP 316
Query: 860 MYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFN 894
Y++ + ARD G + + +++I + D NDN P +
Sbjct: 317 AYEVDVQARDLGPNPIPAHCKVLIKVLDVNDNIPSIH 353
Score = 40.3 bits (90), Expect = 0.052
Identities = 35/112 (31%), Positives = 50/112 (44%), Gaps = 7/112 (6%)
Query: 288 AQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD 347
A VEI++LD+ND+ P F + I E+ + A D D G N TY L
Sbjct: 117 ALIHVEIQVLDINDHQPRFPKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTL-S 175
Query: 348 PKGAFSIDPRSGWLTVRNQTV-----LDREAHSSLRMKVYAKET-NPSVVGT 393
P F++D G ++ + LDRE HS + + A + NP GT
Sbjct: 176 PSEHFALDVIVGPDETKHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGT 227
>AF152517-1|AAD43777.1| 810|Homo sapiens protocadherin gamma B1
short form protein protein.
Length = 810
Score = 104 bits (250), Expect = 2e-21
Identities = 116/468 (24%), Positives = 212/468 (45%), Gaps = 39/468 (8%)
Query: 436 DEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMV 495
D L ++ + + DANDN PVF +Y S++ N GT + +V A D D G N +
Sbjct: 216 DPPLSGTTHIWIRVTDANDNAPVF-SQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEI 274
Query: 496 LYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLA 553
Y ++ TS F +NPNTG ++ + E R+ L VEA D + + +
Sbjct: 275 TYAF--LNSPISTSLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGVHTAHCNVQIE 332
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHG 613
+V N P++ FM + + + +GT + I+V D ++ ++
Sbjct: 333 IV------DENDNAPEV-TFMS--FSNQIPEDSDLGTVIALIKVRD---KDSGQNGMVTC 380
Query: 614 Y-EEGVPFAVEERSG---VITVVDDLSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVD 668
Y +E VPF +E S + + L+R Y+ +A + LS T+ T+H+ D
Sbjct: 381 YTQEEVPFKLESTSKNYYKLVIAGALNREQTADYNVTIIATDKGKPALSSRTSITLHISD 440
Query: 669 VNDERGVLLKGAHSPIIFHVKENS-AGAAIGQIFHTNMSSIYGNGTGNVRFLIAN--QQD 725
+ND V + ++ + HV EN+ GA+I Q+ ++ + NG + L ++ ++
Sbjct: 441 INDNAPVFHQASY---VVHVSENNPPGASIAQVSASD-PDLGPNGRVSYSILASDLEPRE 496
Query: 726 VTDDIAIA-EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
+ ++++ + G +F Q+ D E+ + +T+ A ++G + + + + + D NDN
Sbjct: 497 LLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQAR-DQGSPALSANVSLRVLVGDLNDNA 555
Query: 785 P--VFEHATYEGFIMEN--SKIGTEIKMDNIIKATDADEGTNALFMY-TLFGEGKEMFDV 839
P ++ +G + + + + + A DAD G NA Y L +F +
Sbjct: 556 PRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSL 615
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
TG V+ DR+ +L + RD G LS+ A L ++ D
Sbjct: 616 GLRTGEVRTARALGDRD-AARQRLLVAVRDGGQPPLSATATLHLIFAD 662
Score = 99 bits (238), Expect = 6e-20
Identities = 119/468 (25%), Positives = 194/468 (41%), Gaps = 32/468 (6%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E M+ +V V + D NDN P FV + + + +A G A D D+ N + L
Sbjct: 108 ENPMNVFHVVVVIQDINDNAPRFVAKGI-DLEICESALPGVKFSLDSAQDADVEGNSLKL 166
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLA 553
Y + ++++ + + V + E P+ + H L + A D P L+
Sbjct: 167 YTINPNQYFSLSTKESPDGSKYPVLLLEKPLDREHQSSHRLILTAMDGGDPP------LS 220
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLL 611
T R T N + P F Y + NV GTSV ++ D E +++Y L
Sbjct: 221 GTTHIWIRVTDAND-NAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFL 279
Query: 612 HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVND 671
+ F + +G IT L Y +V ++ + N + +VD ND
Sbjct: 280 NSPISTSLFNLNPNTGDITTNGTLDFEETSRYVL-SVEAKDGGVHTAHCNVQIEIVDEND 338
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
+ + S I +++ G I I + S G V + +
Sbjct: 339 NAPEVTFMSFSNQI--PEDSDLGTVIALIKVRDKDS---GQNGMVTCYTQEEVPFKLEST 393
Query: 732 IAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
+ L+RE+ Y +T+IA +KG + + +T++I D NDN PVF A+
Sbjct: 394 SKNYYKLVIAGALNREQTADYNVTIIAT-DKGKPALSSRTSITLHISDINDNAPVFHQAS 452
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEMF---DVDENTGV 845
Y + EN+ G I + A+D D G N Y++ E +E+ V +GV
Sbjct: 453 YVVHVSENNPPGASIAQ---VSASDPDLGPNGRVSYSILASDLEPRELLSYVSVSPQSGV 509
Query: 846 VKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V F + D E+ ++L+L ARD G LS+ L +++GD NDN P
Sbjct: 510 V-FAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAP 556
Score = 87.4 bits (207), Expect = 3e-16
Identities = 78/266 (29%), Positives = 123/266 (46%), Gaps = 26/266 (9%)
Query: 897 EENSKVRIHRETKLNG--TAGFTI-IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKL 953
EE S+ + E K G TA + IE+ +N A +V + IPE+ +GT I +
Sbjct: 306 EETSRYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDSDLGTVIALI 365
Query: 954 NALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--S 1011
D DSG NG + EV P KL + + K Y+ + ++A +L E +
Sbjct: 366 KVRDKDSGQNGMVTCYTQEEV---PFKLESTS---KNYYKL-------VIAGALNREQTA 412
Query: 1012 EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
++ + I A D G L+ S+ + + D+ND+ PVF + Y +V E + +V A
Sbjct: 413 DYNVTIIATDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSA 472
Query: 1070 TDADFGQNANLTYFIQPSDTD----LPF-EISPLTGVLSVNGELDRETEDKYILTVVARD 1124
+D D G N ++Y I SD + L + +SP +GV+ D E + LT+ ARD
Sbjct: 473 SDPDLGPNGRVSYSILASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARD 532
Query: 1125 NGXXXXXXXXXXXXXXXXDVNDNSPK 1150
G D+NDN+P+
Sbjct: 533 QG-SPALSANVSLRVLVGDLNDNAPR 557
Score = 87.0 bits (206), Expect = 5e-16
Identities = 95/350 (27%), Positives = 162/350 (46%), Gaps = 39/350 (11%)
Query: 1010 ESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKV 1067
+S RL ++A+DGG+ L+ + + V D ND+ PVF + Y +++E + +V
Sbjct: 202 QSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQENVPWGTSVLRV 261
Query: 1068 DATDADFGQNANLTY-FIQ-PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
ATD D G NA +TY F+ P T L F ++P TG ++ NG LD E +Y+L+V A+D
Sbjct: 262 MATDQDEGINAEITYAFLNSPISTSL-FNLNPNTGDITTNGTLDFEETSRYVLSVEAKDG 320
Query: 1126 GXXXXXXXXXXXXXXXXDVNDNSPK--FYAFDELLEWKHPEADELSNHNFESVMMIPVYK 1183
G D NDN+P+ F +F + PE +L + +I V
Sbjct: 321 G---VHTAHCNVQIEIVDENDNAPEVTFMSFSNQI----PEDSDLGT----VIALIKVRD 369
Query: 1184 ATIEENAPIGT-TVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL---------GLPSLS 1233
+N + T +V N L++ R+ + G P+LS
Sbjct: 370 KDSGQNGMVTCYTQEEVPFKLESTSKNYYKLVIAGALNREQTADYNVTIIATDKGKPALS 429
Query: 1234 STAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSLNLTEHYENFKMR 1291
S + + ++D+ D + PVF Y + + EN A + VS + + N ++
Sbjct: 430 SRTSITLHISDIND-----NAPVFHQASYVVHVSENNPPGASIAQVSASDPDLGPNGRVS 484
Query: 1292 YYILNENDTDIRR--TFV-IDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
Y IL +D + R ++V + P++G ++ R+ D E +E+ ++A Q
Sbjct: 485 YSIL-ASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARDQ 533
Score = 86.6 bits (205), Expect = 6e-16
Identities = 59/171 (34%), Positives = 86/171 (50%), Gaps = 13/171 (7%)
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
+ +KPLDRE + +R+ ++ + G +G + I + D NDN PVF Y +
Sbjct: 191 LLLEKPLDREHQSSHRL-ILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQ 249
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGE--GKEMFDVDENTGVVKFIGDSLDR 855
EN GT + + ATD DEG NA Y +F+++ NTG + G +LD
Sbjct: 250 ENVPWGTSVLR---VMATDQDEGINAEITYAFLNSPISTSLFNLNPNTGDITTNG-TLDF 305
Query: 856 EKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEF------NQIEENS 900
E+ Y LS+ A+D G ++ + I I DENDN PE NQI E+S
Sbjct: 306 EETSRYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDS 356
Score = 77.4 bits (182), Expect = 4e-13
Identities = 58/218 (26%), Positives = 101/218 (46%), Gaps = 21/218 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN+P GT+++++ A D D G+N +I Y F + S +S F +N G
Sbjct: 248 LQENVPWGTSVLRVMATDQDEGINAEITYAFLN------SPISTS------LFNLNPNTG 295
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ +L E S + L++ A DGG + +V++ + D ND+ P ++ + E
Sbjct: 296 DITTNGTLDFEETSRYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPED 355
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
V+ + D D GQN +T + Q ++PF++ + L + G L+RE
Sbjct: 356 SDLGTVIALIKVRDKDSGQNGMVTCYTQ---EEVPFKLESTSKNYYKLVIAGALNREQTA 412
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY 1152
Y +T++A D G D+NDN+P F+
Sbjct: 413 DYNVTIIATDKG-KPALSSRTSITLHISDINDNAPVFH 449
Score = 77.0 bits (181), Expect = 5e-13
Identities = 60/170 (35%), Positives = 89/170 (52%), Gaps = 12/170 (7%)
Query: 223 QDLGV-GATLRYELISGNDR-KLFSLDSVNGSLF--LEKELDLDAEHNLQANTFVLQVQA 278
QD V G +L+ I+ N L + +S +GS + L E LD EH ++ L + A
Sbjct: 155 QDADVEGNSLKLYTINPNQYFSLSTKESPDGSKYPVLLLEKPLDREHQ---SSHRLILTA 211
Query: 279 SQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGEN 338
+P + + I + D NDN P F + Y +S+ EN+P G SVL+VMATD+D+G N
Sbjct: 212 MDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGIN 271
Query: 339 GEFTYQ-LDDP--KGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
E TY L+ P F+++P +G +T LD E S + V AK+
Sbjct: 272 AEITYAFLNSPISTSLFNLNPNTGDITTNG--TLDFEETSRYVLSVEAKD 319
Score = 68.5 bits (160), Expect = 2e-10
Identities = 67/245 (27%), Positives = 107/245 (43%), Gaps = 18/245 (7%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
E G + +DREK ++ EF + ++ V + I+D NDN P F +
Sbjct: 77 ESGDLLVNGRIDREKICGRKLECALEFETVAENPMNVFHVVVVIQDINDNAPRFVAKGID 136
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----I 849
I E++ G + +D+ A DAD N+L +YT+ E+ K+ +
Sbjct: 137 LEICESALPGVKFSLDS---AQDADVEGNSLKLYTINPNQYFSLSTKESPDGSKYPVLLL 193
Query: 850 GDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRE 907
LDRE + ++L L A D G LS + I + D NDN P F+Q E +V +
Sbjct: 194 EKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQ--EVYRVSLQE- 250
Query: 908 TKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIR 967
N G +++ V ++ ++ FL N PI T++ LN D NG +
Sbjct: 251 ---NVPWGTSVLRVMATDQDEGINAEITYAFL---NSPISTSLFNLNPNTGDITTNGTLD 304
Query: 968 YEFNS 972
+E S
Sbjct: 305 FEETS 309
Score = 67.3 bits (157), Expect = 4e-10
Identities = 55/164 (33%), Positives = 80/164 (48%), Gaps = 12/164 (7%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I T LD E+ Y ++V E G + A V I I DENDN P ++
Sbjct: 295 GDITTNGTLDFEETSRYVLSV--EAKDGGVHTAHC-NVQIEIVDENDNAPEVTFMSFSNQ 351
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENT-GVVKF-IGDSL 853
I E+S +GT I +IK D D G N M T + + + F ++ + K I +L
Sbjct: 352 IPEDSDLGTVIA---LIKVRDKDSGQNG--MVTCYTQEEVPFKLESTSKNYYKLVIAGAL 406
Query: 854 DREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ 895
+RE+ Y ++++A D G LSS + + I D NDN P F+Q
Sbjct: 407 NREQTADYNVTIIATDKGKPALSSRTSITLHISDINDNAPVFHQ 450
Score = 59.7 bits (138), Expect = 8e-08
Identities = 38/126 (30%), Positives = 62/126 (49%), Gaps = 8/126 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGN-DRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A DQD G+ A + Y ++ LF+L+ G + LD + + + +VL V
Sbjct: 261 VMATDQDEGINAEITYAFLNSPISTSLFNLNPNTGDITTNGTLDFE-----ETSRYVLSV 315
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+A + + TA V+IE++D NDN PE ++ I E+ G + + DKD G
Sbjct: 316 EAK--DGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDSDLGTVIALIKVRDKDSG 373
Query: 337 ENGEFT 342
+NG T
Sbjct: 374 QNGMVT 379
Score = 59.7 bits (138), Expect = 8e-08
Identities = 60/199 (30%), Positives = 91/199 (45%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN P G +I +++A D D G NG++ Y + P LS Y ++ + G
Sbjct: 457 VSENNPPGASIAQVSASDPDLGPNGRVSYSILASDLEPRELLS--------YVSVSPQSG 508
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFP--VFKKTWYNFN 1053
V R+ E F L + A D G+ L+ N+S+RV V D+ND+ P ++ + +
Sbjct: 509 VVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGS 568
Query: 1054 -----VEEAQYTRRVLGKVDATDADFGQNANLTYFI-QPSDTDLPFEISPLTGVLSVNGE 1107
V A ++ KV A DAD G NA L+Y + Q S+ L F + TG +
Sbjct: 569 ALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGL-FSLGLRTGEVRTARA 627
Query: 1108 LDRETEDKYILTVVARDNG 1126
L + L V RD G
Sbjct: 628 LGDRDAARQRLLVAVRDGG 646
Score = 59.3 bits (137), Expect = 1e-07
Identities = 71/335 (21%), Positives = 134/335 (40%), Gaps = 27/335 (8%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L + G +S + + + D NDN P+F Y V++ E P G +
Sbjct: 209 LTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDE 268
Query: 127 SLTIPLTV-----PRGLTIFK-DIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKP 180
+ +T P ++F + D T + + V + + ++H
Sbjct: 269 GINAEITYAFLNSPISTSLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGVHTAHCN 328
Query: 181 VLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI---DQDLGVGATLRYELIS 237
V ++ D D ++ M+ +I ++ I I D+D G +
Sbjct: 329 V----QIEIVDENDNAPEVTFMSFSNQIPEDSDLGTVIALIKVRDKDSGQNGMVTCYT-- 382
Query: 238 GNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELL 297
+ F L+S + + + K + A + Q + + + A+ P +++ + + +
Sbjct: 383 -QEEVPFKLESTSKNYY--KLVIAGALNREQTADYNVTIIATDKGKPALSSRTSITLHIS 439
Query: 298 DLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL---D-DPK---G 350
D+NDN P F Y + + EN P G S+ QV A+D D G NG +Y + D +P+
Sbjct: 440 DINDNAPVFHQASYVVHVSENNPPGASIAQVSASDPDLGPNGRVSYSILASDLEPRELLS 499
Query: 351 AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
S+ P+SG V Q D E + + + A++
Sbjct: 500 YVSVSPQSG--VVFAQRAFDHEQLRAFELTLQARD 532
Score = 49.6 bits (113), Expect = 8e-05
Identities = 50/172 (29%), Positives = 81/172 (47%), Gaps = 24/172 (13%)
Query: 218 IHAIDQDLGVGATLRYELISGN--DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTF 272
+ A D DLG + Y +++ + R+L S SV+ G +F ++ D + Q F
Sbjct: 470 VSASDPDLGPNGRVSYSILASDLEPRELLSYVSVSPQSGVVFAQRAFDHE-----QLRAF 524
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLPN----GFSV 325
L +QA +P +A + + + DLNDN P + ++ + +P G+ V
Sbjct: 525 ELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLV 584
Query: 326 LQVMATDKDQGENGEFTY---QLDDPKGAFSIDPRSGWLTVRNQTVL-DREA 373
+V+A D D G N +Y Q +P G FS+ R+G VR L DR+A
Sbjct: 585 TKVVAVDADSGHNAWLSYHVLQASEP-GLFSLGLRTG--EVRTARALGDRDA 633
Score = 49.2 bits (112), Expect = 1e-04
Identities = 62/246 (25%), Positives = 107/246 (43%), Gaps = 13/246 (5%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L S ++ + + D NDN PVF ++ Y + N G I +V A DPDLG NG V Y
Sbjct: 428 LSSRTSITLHISDINDNAPVFHQAS-YVVHVSENNPPGASIAQVSASDPDLGPNGRVSYS 486
Query: 499 LQRT--SNLTITSPFKINPNTGTVSVAESPILEGRHA--LFVEASDQPANPSERRYSLAV 554
+ + + S ++P +G V + E A L ++A DQ + SL V
Sbjct: 487 ILASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRV 546
Query: 555 VTIEVT-RGTKGNKPDI-PDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND--VSYDL 610
+ ++ + P + PD G+ V G V ++ DA ++ +SY +
Sbjct: 547 LVGDLNDNAPRVLYPALGPD--GSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHV 604
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L E G+ F++ R+G + L + VA+++ + AT+H++ +
Sbjct: 605 LQASEPGL-FSLGLRTGEVRTARALGDRDAARQRL-LVAVRDGGQPPLSATATLHLIFAD 662
Query: 671 DERGVL 676
+ VL
Sbjct: 663 SLQEVL 668
Score = 39.1 bits (87), Expect = 0.12
Identities = 47/190 (24%), Positives = 71/190 (37%), Gaps = 14/190 (7%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT- 1089
V V ++D+ND+ P F + + E+ A DAD N+ Y I P+
Sbjct: 116 VVVVIQDINDNAPRFVAKGIDLEICESALPGVKFSLDSAQDADVEGNSLKLYTINPNQYF 175
Query: 1090 DLPFEISPLTG---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
L + SP VL + LDRE + + L + A D G D ND
Sbjct: 176 SLSTKESPDGSKYPVLLLEKPLDREHQSSHRLILTAMDGG-DPPLSGTTHIWIRVTDAND 234
Query: 1147 NSPKF------YAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVF 1200
N+P F + E + W ++ E + Y N+PI T++ +
Sbjct: 235 NAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFL---NSPISTSLFNLN 291
Query: 1201 ANDTDFIGNG 1210
N D NG
Sbjct: 292 PNTGDITTNG 301
>AF152330-1|AAD43724.1| 927|Homo sapiens protocadherin gamma B1
protein.
Length = 927
Score = 104 bits (250), Expect = 2e-21
Identities = 116/468 (24%), Positives = 212/468 (45%), Gaps = 39/468 (8%)
Query: 436 DEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMV 495
D L ++ + + DANDN PVF +Y S++ N GT + +V A D D G N +
Sbjct: 216 DPPLSGTTHIWIRVTDANDNAPVF-SQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEI 274
Query: 496 LYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLA 553
Y ++ TS F +NPNTG ++ + E R+ L VEA D + + +
Sbjct: 275 TYAF--LNSPISTSLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGVHTAHCNVQIE 332
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHG 613
+V N P++ FM + + + +GT + I+V D ++ ++
Sbjct: 333 IV------DENDNAPEV-TFMS--FSNQIPEDSDLGTVIALIKVRD---KDSGQNGMVTC 380
Query: 614 Y-EEGVPFAVEERSG---VITVVDDLSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVD 668
Y +E VPF +E S + + L+R Y+ +A + LS T+ T+H+ D
Sbjct: 381 YTQEEVPFKLESTSKNYYKLVIAGALNREQTADYNVTIIATDKGKPALSSRTSITLHISD 440
Query: 669 VNDERGVLLKGAHSPIIFHVKENS-AGAAIGQIFHTNMSSIYGNGTGNVRFLIAN--QQD 725
+ND V + ++ + HV EN+ GA+I Q+ ++ + NG + L ++ ++
Sbjct: 441 INDNAPVFHQASY---VVHVSENNPPGASIAQVSASD-PDLGPNGRVSYSILASDLEPRE 496
Query: 726 VTDDIAIA-EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
+ ++++ + G +F Q+ D E+ + +T+ A ++G + + + + + D NDN
Sbjct: 497 LLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQAR-DQGSPALSANVSLRVLVGDLNDNA 555
Query: 785 P--VFEHATYEGFIMEN--SKIGTEIKMDNIIKATDADEGTNALFMY-TLFGEGKEMFDV 839
P ++ +G + + + + + A DAD G NA Y L +F +
Sbjct: 556 PRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSL 615
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
TG V+ DR+ +L + RD G LS+ A L ++ D
Sbjct: 616 GLRTGEVRTARALGDRD-AARQRLLVAVRDGGQPPLSATATLHLIFAD 662
Score = 99 bits (238), Expect = 6e-20
Identities = 119/468 (25%), Positives = 194/468 (41%), Gaps = 32/468 (6%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E M+ +V V + D NDN P FV + + + +A G A D D+ N + L
Sbjct: 108 ENPMNVFHVVVVIQDINDNAPRFVAKGI-DLEICESALPGVKFSLDSAQDADVEGNSLKL 166
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLA 553
Y + ++++ + + V + E P+ + H L + A D P L+
Sbjct: 167 YTINPNQYFSLSTKESPDGSKYPVLLLEKPLDREHQSSHRLILTAMDGGDPP------LS 220
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLL 611
T R T N + P F Y + NV GTSV ++ D E +++Y L
Sbjct: 221 GTTHIWIRVTDAND-NAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFL 279
Query: 612 HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVND 671
+ F + +G IT L Y +V ++ + N + +VD ND
Sbjct: 280 NSPISTSLFNLNPNTGDITTNGTLDFEETSRYVL-SVEAKDGGVHTAHCNVQIEIVDEND 338
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
+ + S I +++ G I I + S G V + +
Sbjct: 339 NAPEVTFMSFSNQI--PEDSDLGTVIALIKVRDKDS---GQNGMVTCYTQEEVPFKLEST 393
Query: 732 IAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
+ L+RE+ Y +T+IA +KG + + +T++I D NDN PVF A+
Sbjct: 394 SKNYYKLVIAGALNREQTADYNVTIIAT-DKGKPALSSRTSITLHISDINDNAPVFHQAS 452
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEMF---DVDENTGV 845
Y + EN+ G I + A+D D G N Y++ E +E+ V +GV
Sbjct: 453 YVVHVSENNPPGASIAQ---VSASDPDLGPNGRVSYSILASDLEPRELLSYVSVSPQSGV 509
Query: 846 VKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V F + D E+ ++L+L ARD G LS+ L +++GD NDN P
Sbjct: 510 V-FAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAP 556
Score = 87.4 bits (207), Expect = 3e-16
Identities = 78/266 (29%), Positives = 123/266 (46%), Gaps = 26/266 (9%)
Query: 897 EENSKVRIHRETKLNG--TAGFTI-IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKL 953
EE S+ + E K G TA + IE+ +N A +V + IPE+ +GT I +
Sbjct: 306 EETSRYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDSDLGTVIALI 365
Query: 954 NALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--S 1011
D DSG NG + EV P KL + + K Y+ + ++A +L E +
Sbjct: 366 KVRDKDSGQNGMVTCYTQEEV---PFKLESTS---KNYYKL-------VIAGALNREQTA 412
Query: 1012 EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
++ + I A D G L+ S+ + + D+ND+ PVF + Y +V E + +V A
Sbjct: 413 DYNVTIIATDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSA 472
Query: 1070 TDADFGQNANLTYFIQPSDTD----LPF-EISPLTGVLSVNGELDRETEDKYILTVVARD 1124
+D D G N ++Y I SD + L + +SP +GV+ D E + LT+ ARD
Sbjct: 473 SDPDLGPNGRVSYSILASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARD 532
Query: 1125 NGXXXXXXXXXXXXXXXXDVNDNSPK 1150
G D+NDN+P+
Sbjct: 533 QG-SPALSANVSLRVLVGDLNDNAPR 557
Score = 87.0 bits (206), Expect = 5e-16
Identities = 95/350 (27%), Positives = 162/350 (46%), Gaps = 39/350 (11%)
Query: 1010 ESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKV 1067
+S RL ++A+DGG+ L+ + + V D ND+ PVF + Y +++E + +V
Sbjct: 202 QSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQENVPWGTSVLRV 261
Query: 1068 DATDADFGQNANLTY-FIQ-PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
ATD D G NA +TY F+ P T L F ++P TG ++ NG LD E +Y+L+V A+D
Sbjct: 262 MATDQDEGINAEITYAFLNSPISTSL-FNLNPNTGDITTNGTLDFEETSRYVLSVEAKDG 320
Query: 1126 GXXXXXXXXXXXXXXXXDVNDNSPK--FYAFDELLEWKHPEADELSNHNFESVMMIPVYK 1183
G D NDN+P+ F +F + PE +L + +I V
Sbjct: 321 G---VHTAHCNVQIEIVDENDNAPEVTFMSFSNQI----PEDSDLGT----VIALIKVRD 369
Query: 1184 ATIEENAPIGT-TVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL---------GLPSLS 1233
+N + T +V N L++ R+ + G P+LS
Sbjct: 370 KDSGQNGMVTCYTQEEVPFKLESTSKNYYKLVIAGALNREQTADYNVTIIATDKGKPALS 429
Query: 1234 STAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSLNLTEHYENFKMR 1291
S + + ++D+ D + PVF Y + + EN A + VS + + N ++
Sbjct: 430 SRTSITLHISDIND-----NAPVFHQASYVVHVSENNPPGASIAQVSASDPDLGPNGRVS 484
Query: 1292 YYILNENDTDIRR--TFV-IDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
Y IL +D + R ++V + P++G ++ R+ D E +E+ ++A Q
Sbjct: 485 YSIL-ASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARDQ 533
Score = 86.6 bits (205), Expect = 6e-16
Identities = 59/171 (34%), Positives = 86/171 (50%), Gaps = 13/171 (7%)
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
+ +KPLDRE + +R+ ++ + G +G + I + D NDN PVF Y +
Sbjct: 191 LLLEKPLDREHQSSHRL-ILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQ 249
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGE--GKEMFDVDENTGVVKFIGDSLDR 855
EN GT + + ATD DEG NA Y +F+++ NTG + G +LD
Sbjct: 250 ENVPWGTSVLR---VMATDQDEGINAEITYAFLNSPISTSLFNLNPNTGDITTNG-TLDF 305
Query: 856 EKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEF------NQIEENS 900
E+ Y LS+ A+D G ++ + I I DENDN PE NQI E+S
Sbjct: 306 EETSRYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDS 356
Score = 77.4 bits (182), Expect = 4e-13
Identities = 58/218 (26%), Positives = 101/218 (46%), Gaps = 21/218 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN+P GT+++++ A D D G+N +I Y F + S +S F +N G
Sbjct: 248 LQENVPWGTSVLRVMATDQDEGINAEITYAFLN------SPISTS------LFNLNPNTG 295
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ +L E S + L++ A DGG + +V++ + D ND+ P ++ + E
Sbjct: 296 DITTNGTLDFEETSRYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPED 355
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
V+ + D D GQN +T + Q ++PF++ + L + G L+RE
Sbjct: 356 SDLGTVIALIKVRDKDSGQNGMVTCYTQ---EEVPFKLESTSKNYYKLVIAGALNREQTA 412
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY 1152
Y +T++A D G D+NDN+P F+
Sbjct: 413 DYNVTIIATDKG-KPALSSRTSITLHISDINDNAPVFH 449
Score = 77.0 bits (181), Expect = 5e-13
Identities = 60/170 (35%), Positives = 89/170 (52%), Gaps = 12/170 (7%)
Query: 223 QDLGV-GATLRYELISGNDR-KLFSLDSVNGSLF--LEKELDLDAEHNLQANTFVLQVQA 278
QD V G +L+ I+ N L + +S +GS + L E LD EH ++ L + A
Sbjct: 155 QDADVEGNSLKLYTINPNQYFSLSTKESPDGSKYPVLLLEKPLDREHQ---SSHRLILTA 211
Query: 279 SQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGEN 338
+P + + I + D NDN P F + Y +S+ EN+P G SVL+VMATD+D+G N
Sbjct: 212 MDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGIN 271
Query: 339 GEFTYQ-LDDP--KGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
E TY L+ P F+++P +G +T LD E S + V AK+
Sbjct: 272 AEITYAFLNSPISTSLFNLNPNTGDITTNG--TLDFEETSRYVLSVEAKD 319
Score = 68.5 bits (160), Expect = 2e-10
Identities = 67/245 (27%), Positives = 107/245 (43%), Gaps = 18/245 (7%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
E G + +DREK ++ EF + ++ V + I+D NDN P F +
Sbjct: 77 ESGDLLVNGRIDREKICGRKLECALEFETVAENPMNVFHVVVVIQDINDNAPRFVAKGID 136
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----I 849
I E++ G + +D+ A DAD N+L +YT+ E+ K+ +
Sbjct: 137 LEICESALPGVKFSLDS---AQDADVEGNSLKLYTINPNQYFSLSTKESPDGSKYPVLLL 193
Query: 850 GDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRE 907
LDRE + ++L L A D G LS + I + D NDN P F+Q E +V +
Sbjct: 194 EKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQ--EVYRVSLQE- 250
Query: 908 TKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIR 967
N G +++ V ++ ++ FL N PI T++ LN D NG +
Sbjct: 251 ---NVPWGTSVLRVMATDQDEGINAEITYAFL---NSPISTSLFNLNPNTGDITTNGTLD 304
Query: 968 YEFNS 972
+E S
Sbjct: 305 FEETS 309
Score = 67.3 bits (157), Expect = 4e-10
Identities = 55/164 (33%), Positives = 80/164 (48%), Gaps = 12/164 (7%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I T LD E+ Y ++V E G + A V I I DENDN P ++
Sbjct: 295 GDITTNGTLDFEETSRYVLSV--EAKDGGVHTAHC-NVQIEIVDENDNAPEVTFMSFSNQ 351
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENT-GVVKF-IGDSL 853
I E+S +GT I +IK D D G N M T + + + F ++ + K I +L
Sbjct: 352 IPEDSDLGTVIA---LIKVRDKDSGQNG--MVTCYTQEEVPFKLESTSKNYYKLVIAGAL 406
Query: 854 DREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ 895
+RE+ Y ++++A D G LSS + + I D NDN P F+Q
Sbjct: 407 NREQTADYNVTIIATDKGKPALSSRTSITLHISDINDNAPVFHQ 450
Score = 59.7 bits (138), Expect = 8e-08
Identities = 38/126 (30%), Positives = 62/126 (49%), Gaps = 8/126 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGN-DRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A DQD G+ A + Y ++ LF+L+ G + LD + + + +VL V
Sbjct: 261 VMATDQDEGINAEITYAFLNSPISTSLFNLNPNTGDITTNGTLDFE-----ETSRYVLSV 315
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+A + + TA V+IE++D NDN PE ++ I E+ G + + DKD G
Sbjct: 316 EAK--DGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDSDLGTVIALIKVRDKDSG 373
Query: 337 ENGEFT 342
+NG T
Sbjct: 374 QNGMVT 379
Score = 59.7 bits (138), Expect = 8e-08
Identities = 60/199 (30%), Positives = 91/199 (45%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN P G +I +++A D D G NG++ Y + P LS Y ++ + G
Sbjct: 457 VSENNPPGASIAQVSASDPDLGPNGRVSYSILASDLEPRELLS--------YVSVSPQSG 508
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFP--VFKKTWYNFN 1053
V R+ E F L + A D G+ L+ N+S+RV V D+ND+ P ++ + +
Sbjct: 509 VVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGS 568
Query: 1054 -----VEEAQYTRRVLGKVDATDADFGQNANLTYFI-QPSDTDLPFEISPLTGVLSVNGE 1107
V A ++ KV A DAD G NA L+Y + Q S+ L F + TG +
Sbjct: 569 ALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGL-FSLGLRTGEVRTARA 627
Query: 1108 LDRETEDKYILTVVARDNG 1126
L + L V RD G
Sbjct: 628 LGDRDAARQRLLVAVRDGG 646
Score = 59.3 bits (137), Expect = 1e-07
Identities = 71/335 (21%), Positives = 134/335 (40%), Gaps = 27/335 (8%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L + G +S + + + D NDN P+F Y V++ E P G +
Sbjct: 209 LTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDE 268
Query: 127 SLTIPLTV-----PRGLTIFK-DIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKP 180
+ +T P ++F + D T + + V + + ++H
Sbjct: 269 GINAEITYAFLNSPISTSLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGVHTAHCN 328
Query: 181 VLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI---DQDLGVGATLRYELIS 237
V ++ D D ++ M+ +I ++ I I D+D G +
Sbjct: 329 V----QIEIVDENDNAPEVTFMSFSNQIPEDSDLGTVIALIKVRDKDSGQNGMVTCYT-- 382
Query: 238 GNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELL 297
+ F L+S + + + K + A + Q + + + A+ P +++ + + +
Sbjct: 383 -QEEVPFKLESTSKNYY--KLVIAGALNREQTADYNVTIIATDKGKPALSSRTSITLHIS 439
Query: 298 DLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL---D-DPK---G 350
D+NDN P F Y + + EN P G S+ QV A+D D G NG +Y + D +P+
Sbjct: 440 DINDNAPVFHQASYVVHVSENNPPGASIAQVSASDPDLGPNGRVSYSILASDLEPRELLS 499
Query: 351 AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
S+ P+SG V Q D E + + + A++
Sbjct: 500 YVSVSPQSG--VVFAQRAFDHEQLRAFELTLQARD 532
Score = 49.6 bits (113), Expect = 8e-05
Identities = 50/172 (29%), Positives = 81/172 (47%), Gaps = 24/172 (13%)
Query: 218 IHAIDQDLGVGATLRYELISGN--DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTF 272
+ A D DLG + Y +++ + R+L S SV+ G +F ++ D + Q F
Sbjct: 470 VSASDPDLGPNGRVSYSILASDLEPRELLSYVSVSPQSGVVFAQRAFDHE-----QLRAF 524
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLPN----GFSV 325
L +QA +P +A + + + DLNDN P + ++ + +P G+ V
Sbjct: 525 ELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLV 584
Query: 326 LQVMATDKDQGENGEFTY---QLDDPKGAFSIDPRSGWLTVRNQTVL-DREA 373
+V+A D D G N +Y Q +P G FS+ R+G VR L DR+A
Sbjct: 585 TKVVAVDADSGHNAWLSYHVLQASEP-GLFSLGLRTG--EVRTARALGDRDA 633
Score = 49.2 bits (112), Expect = 1e-04
Identities = 62/246 (25%), Positives = 107/246 (43%), Gaps = 13/246 (5%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L S ++ + + D NDN PVF ++ Y + N G I +V A DPDLG NG V Y
Sbjct: 428 LSSRTSITLHISDINDNAPVFHQAS-YVVHVSENNPPGASIAQVSASDPDLGPNGRVSYS 486
Query: 499 LQRT--SNLTITSPFKINPNTGTVSVAESPILEGRHA--LFVEASDQPANPSERRYSLAV 554
+ + + S ++P +G V + E A L ++A DQ + SL V
Sbjct: 487 ILASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRV 546
Query: 555 VTIEVT-RGTKGNKPDI-PDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND--VSYDL 610
+ ++ + P + PD G+ V G V ++ DA ++ +SY +
Sbjct: 547 LVGDLNDNAPRVLYPALGPD--GSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHV 604
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L E G+ F++ R+G + L + VA+++ + AT+H++ +
Sbjct: 605 LQASEPGL-FSLGLRTGEVRTARALGDRDAARQRL-LVAVRDGGQPPLSATATLHLIFAD 662
Query: 671 DERGVL 676
+ VL
Sbjct: 663 SLQEVL 668
Score = 39.1 bits (87), Expect = 0.12
Identities = 47/190 (24%), Positives = 71/190 (37%), Gaps = 14/190 (7%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT- 1089
V V ++D+ND+ P F + + E+ A DAD N+ Y I P+
Sbjct: 116 VVVVIQDINDNAPRFVAKGIDLEICESALPGVKFSLDSAQDADVEGNSLKLYTINPNQYF 175
Query: 1090 DLPFEISPLTG---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
L + SP VL + LDRE + + L + A D G D ND
Sbjct: 176 SLSTKESPDGSKYPVLLLEKPLDREHQSSHRLILTAMDGG-DPPLSGTTHIWIRVTDAND 234
Query: 1147 NSPKF------YAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVF 1200
N+P F + E + W ++ E + Y N+PI T++ +
Sbjct: 235 NAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFL---NSPISTSLFNLN 291
Query: 1201 ANDTDFIGNG 1210
N D NG
Sbjct: 292 PNTGDITTNG 301
>AB208958-1|BAD92195.1| 895|Homo sapiens protocadherin gamma
subfamily A, 7 isoform 1 precursor variant protein.
Length = 895
Score = 104 bits (250), Expect = 2e-21
Identities = 117/478 (24%), Positives = 192/478 (40%), Gaps = 37/478 (7%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
N E M+ ++V ++D NDN P F+ + + N G +A DPD+G
Sbjct: 68 NFNILMEDKMNLYPIDVEIIDINDNVPRFLTEEI-NVKIMENTAPGVRFPLSEAGDPDVG 126
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSE 547
N + Y L + ++ + V E + E H L ASD P
Sbjct: 127 TNSLQSYQLSPNRHFSLAVQSGDDGTKYPELVLERVLDREEERVHHLVFTASDGGDPPRS 186
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVS 607
+ V ++V T P F Y+ V NV +GT + + D E V+
Sbjct: 187 STAHIQVTVVDVNDHT-------PVFSLPQYQVTVPENVPVGTRLLTVHAIDLDE--GVN 237
Query: 608 YDLLHGYEEGVP-----FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNA 662
++ + + + P F + +G I+ ++ L Y+ E A Q+
Sbjct: 238 GEVTYSFRKITPKLPKMFHLNSLTGEISTLEGLDYEETAFYEMEVQA-QDGPGSLTKAKV 296
Query: 663 TVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIAN 722
+ V+DVND + + S I ++ G I + + S G V I
Sbjct: 297 LITVLDVNDNAPEVTMTSLSSSI--PEDTPLGTVIALFYLQDRDS---GKNGEVTCTIPE 351
Query: 723 QQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEND 782
+ +I + T K LDRE +Y +T+ A + G + + + + D ND
Sbjct: 352 NLPFKLEKSIDNYYRLVTTKNLDRETLSLYNITLKAT-DGGTPPLSRETHIFMQVADTND 410
Query: 783 NPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEM 836
NPP F H++Y +I EN+ G I ++ A D D NA Y+L +
Sbjct: 411 NPPTFPHSSYSVYIAENNPRGASI---FLVTAQDHDSEDNAQITYSLAEDTIQGAPVSSY 467
Query: 837 FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
++ +TGV+ + S D E+ +L + A D+G LSS L + + D+NDN PE
Sbjct: 468 VSINSDTGVL-YALQSFDYEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPE 524
Score = 78.6 bits (185), Expect = 2e-13
Identities = 61/217 (28%), Positives = 93/217 (42%), Gaps = 20/217 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+PEN+P+GT ++ ++A+DLD G+NG++ Y F I P ++ + F +N G
Sbjct: 214 VPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRK---ITP--------KLPKMFHLNSLTG 262
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ L E + + + A DG V + V DVND+ P T + ++ E
Sbjct: 263 EISTLEGLDYEETAFYEMEVQAQDGPGSLTKAKVLITVLDVNDNAPEVTMTSLSSSIPED 322
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
V+ D D G+N +T I +LPF++ L LDRET
Sbjct: 323 TPLGTVIALFYLQDRDSGKNGEVTCTI---PENLPFKLEKSIDNYYRLVTTKNLDRETLS 379
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
Y +T+ A D G D NDN P F
Sbjct: 380 LYNITLKATDGG-TPPLSRETHIFMQVADTNDNPPTF 415
Score = 74.5 bits (175), Expect = 3e-12
Identities = 71/297 (23%), Positives = 138/297 (46%), Gaps = 29/297 (9%)
Query: 620 FAVEERSGVITVVDDLSRYN------RPMYDFEAVALQENANLSIVTNATVHVVDVNDER 673
FA+ +RSG + + R R + +F + +++ NL + V ++D+ND
Sbjct: 38 FALNQRSGSLVTAGRIDREEICAQSARCLVNFN-ILMEDKMNLYPID---VEIIDINDNV 93
Query: 674 GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLIANQQDVTDDIAI 732
L I + EN+A G F + + GT +++ + ++ + + +
Sbjct: 94 PRFLT---EEINVKIMENTAP---GVRFPLSEAGDPDVGTNSLQSYQLSPNRHFSLAVQS 147
Query: 733 AEDGT----IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
+DGT + ++ LDRE+ V+ + A + G + + + + D ND+ PVF
Sbjct: 148 GDDGTKYPELVLERVLDREEERVHHLVFTAS-DGGDPPRSSTAHIQVTVVDVNDHTPVFS 206
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYT---LFGEGKEMFDVDENTGV 845
Y+ + EN +GT + + A D DEG N Y+ + + +MF ++ TG
Sbjct: 207 LPQYQVTVPENVPVGTRLLT---VHAIDLDEGVNGEVTYSFRKITPKLPKMFHLNSLTGE 263
Query: 846 VKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKV 902
+ + + LD E+ Y++ + A+D G ++A+++I + D NDN PE +S +
Sbjct: 264 ISTL-EGLDYEETAFYEMEVQAQDGPGSLTKAKVLITVLDVNDNAPEVTMTSLSSSI 319
Score = 65.7 bits (153), Expect = 1e-09
Identities = 54/173 (31%), Positives = 85/173 (49%), Gaps = 15/173 (8%)
Query: 218 IHAIDQDLGVGATLRYEL--ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+HAID D GV + Y I+ K+F L+S+ G + + LD + + + ++
Sbjct: 227 VHAIDLDEGVNGEVTYSFRKITPKLPKMFHLNSLTGEISTLEGLDYE-----ETAFYEME 281
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
VQA + P +A+V I +LD+NDN PE + + SI E+ P G + D+D
Sbjct: 282 VQAQ--DGPGSLTKAKVLITVLDVNDNAPEVTMTSLSSSIPEDTPLGTVIALFYLQDRDS 339
Query: 336 GENGEFTYQLDDP---KGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
G+NGE T + + K SID +T +N LDRE S + + A +
Sbjct: 340 GKNGEVTCTIPENLPFKLEKSIDNYYRLVTTKN---LDRETLSLYNITLKATD 389
Score = 64.1 bits (149), Expect = 4e-09
Identities = 92/347 (26%), Positives = 137/347 (39%), Gaps = 32/347 (9%)
Query: 997 RHGHVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
++ +++ R L E E L +A DGG+ + ++V V DVNDH PVF Y
Sbjct: 153 KYPELVLERVLDREEERVHHLVFTASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQYQV 212
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP--FEISPLTGVLSVNGELDR 1110
V E L V A D D G N +TY + LP F ++ LTG +S LD
Sbjct: 213 TVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKITPKLPKMFHLNSLTGEISTLEGLDY 272
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSN 1170
E Y + V A+D DVNDN+P+ L PE L
Sbjct: 273 EETAFYEMEVQAQDG---PGSLTKAKVLITVLDVNDNAPEVTMTS--LSSSIPEDTPLGT 327
Query: 1171 -------HNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQR 1221
+ +S V TI EN P + ++ + T + L LY++ +
Sbjct: 328 VIALFYLQDRDSGKNGEV-TCTIPENLPFKLEKSIDNYYRLVTTKNLDRETLSLYNITLK 386
Query: 1222 KNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSL 1279
G P LS + + VAD D + P F Y + I EN A + LV+
Sbjct: 387 ATDG--GTPPLSRETHIFMQVADTND-----NPPTFPHSSYSVYIAENNPRGASIFLVTA 439
Query: 1280 NLTEHYENFKMRYYILNE--NDTDIRRTFVIDPRNGTLYLVRSPDRE 1324
+ +N ++ Y + + + I+ G LY ++S D E
Sbjct: 440 QDHDSEDNAQITYSLAEDTIQGAPVSSYVSINSDTGVLYALQSFDYE 486
Score = 63.7 bits (148), Expect = 5e-09
Identities = 38/124 (30%), Positives = 64/124 (51%), Gaps = 5/124 (4%)
Query: 222 DQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELD--LDAEHNLQANTFVLQVQAS 279
D D+G + Y+L L +G+ + E L+ LD E + L AS
Sbjct: 122 DPDVGTNSLQSYQLSPNRHFSLAVQSGDDGTKYPELVLERVLDRE---EERVHHLVFTAS 178
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
+P +++ A +++ ++D+ND+ P F + Y +++ EN+P G +L V A D D+G NG
Sbjct: 179 DGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQYQVTVPENVPVGTRLLTVHAIDLDEGVNG 238
Query: 340 EFTY 343
E TY
Sbjct: 239 EVTY 242
Score = 58.4 bits (135), Expect = 2e-07
Identities = 72/305 (23%), Positives = 120/305 (39%), Gaps = 33/305 (10%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRG 137
+A++ VTV DVND+ P+F Y VTV E P G + + + +T
Sbjct: 188 TAHIQVTVV--DVNDHTPVFSLPQYQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTY--- 242
Query: 138 LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGD--K 195
+F + P P H + ++G L+ + G K
Sbjct: 243 --------SFRKITPKLPKM-FHLNSLTGEISTLEGLDYEETAFYEMEVQAQDGPGSLTK 293
Query: 196 EFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELI----SGNDRKLFSLDSVNG 251
L+ + E+ +I +D +G + + SG + ++ N
Sbjct: 294 AKVLITVLDVNDNAPEVTMTSLSSSIPEDTPLGTVIALFYLQDRDSGKNGEVTCTIPENL 353
Query: 252 SLFLEKELD----LDAEHNLQANTFVLQ---VQASQLNNPLKTAQARVEIELLDLNDNLP 304
LEK +D L NL T L ++A+ P + + + +++ D NDN P
Sbjct: 354 PFKLEKSIDNYYRLVTTKNLDRETLSLYNITLKATDGGTPPLSRETHIFMQVADTNDNPP 413
Query: 305 EFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLT 362
F Y++ I EN P G S+ V A D D +N + TY L D +GA P S +++
Sbjct: 414 TFPHSSYSVYIAENNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGA----PVSSYVS 469
Query: 363 VRNQT 367
+ + T
Sbjct: 470 INSDT 474
Score = 58.0 bits (134), Expect = 2e-07
Identities = 66/247 (26%), Positives = 96/247 (38%), Gaps = 23/247 (9%)
Query: 913 TAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNS 972
T +I V N A +V IPE+ P+GT I D DSG NG++
Sbjct: 292 TKAKVLITVLDVNDNAPEVTMTSLSSSIPEDTPLGTVIALFYLQDRDSGKNGEVTCTIPE 351
Query: 973 EVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN--LNDN 1028
+ P KL + Y+ ++ ++L E S + + + A DGG L+
Sbjct: 352 NL---PFKLEK---SIDNYY-------RLVTTKNLDRETLSLYNITLKATDGGTPPLSRE 398
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-----F 1083
+ + V D ND+ P F + Y+ + E + V A D D NA +TY
Sbjct: 399 THIFMQVADTNDNPPTFPHSSYSVYIAENNPRGASIFLVTAQDHDSEDNAQITYSLAEDT 458
Query: 1084 IQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXD 1143
IQ + I+ TGVL D E + L V A D+G D
Sbjct: 459 IQGAPVSSYVSINSDTGVLYALQSFDYEQLRELQLRVTAHDSG-DPPLSSNMSLSLFVLD 517
Query: 1144 VNDNSPK 1150
NDN P+
Sbjct: 518 QNDNPPE 524
Score = 56.4 bits (130), Expect = 7e-07
Identities = 61/199 (30%), Positives = 89/199 (44%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I EN P G +I + A D DS N QI Y + + V Y IN G
Sbjct: 424 IAENNPRGASIFLVTAQDHDSEDNAQITYSLAED--------TIQGAPVSSYVSINSDTG 475
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFK----KTWYN 1051
+ +S E E +L ++A D G+ L+ N+S+ +FV D ND+ P T +
Sbjct: 476 VLYALQSFDYEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPEILYPALPTDGS 535
Query: 1052 FNVEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG-VLSVNGE 1107
+E A + ++ KV A D D GQNA L+Y + + F + TG V +
Sbjct: 536 TGMELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYLLLKASEPGLFAVGLYTGEVRTARAL 595
Query: 1108 LDRETEDKYILTVVARDNG 1126
LDR+ K L V +D+G
Sbjct: 596 LDRDAL-KQSLVVAVQDHG 613
Score = 56.0 bits (129), Expect = 1e-06
Identities = 47/160 (29%), Positives = 70/160 (43%), Gaps = 8/160 (5%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I T + LD E+ Y M V A+ G ++ A +V I + D NDN P +
Sbjct: 262 GEISTLEGLDYEETAFYEMEVQAQDGPGSLTKA---KVLITVLDVNDNAPEVTMTSLSSS 318
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
I E++ +GT I + + D D G N T+ + + +LDR
Sbjct: 319 IPEDTPLGTVIALFYL---QDRDSGKNGEVTCTIPENLPFKLEKSIDNYYRLVTTKNLDR 375
Query: 856 EKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEF 893
E +Y ++L A D G LS E + + + D NDN P F
Sbjct: 376 ETLSLYNITLKATDGGTPPLSRETHIFMQVADTNDNPPTF 415
Score = 50.4 bits (115), Expect = 5e-05
Identities = 38/125 (30%), Positives = 61/125 (48%), Gaps = 5/125 (4%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
+IS +LF+L+ +GSL +D + + A + V + L K +++
Sbjct: 29 IISRGRTQLFALNQRSGSLVTAGRIDRE---EICAQSARCLVNFNILMED-KMNLYPIDV 84
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
E++D+NDN+P F + N+ I+EN G A D D G N +YQL P FS+
Sbjct: 85 EIIDINDNVPRFLTEEINVKIMENTAPGVRFPLSEAGDPDVGTNSLQSYQL-SPNRHFSL 143
Query: 355 DPRSG 359
+SG
Sbjct: 144 AVQSG 148
Score = 47.2 bits (107), Expect = 5e-04
Identities = 76/314 (24%), Positives = 127/314 (40%), Gaps = 32/314 (10%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP--IGPSLTIPLTVPRGLTI 140
V + + DVNDN P T ++ E TP G +F + G + + T+P L
Sbjct: 296 VLITVLDVNDNAPEVTMTSLSSSIPEDTPLGTVIALFYLQDRDSGKNGEVTCTIPENLP- 354
Query: 141 FKDIRAFDR--DKPNTPNSDVH----YSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
FK ++ D T N D Y+I DG S + + +V D +
Sbjct: 355 FKLEKSIDNYYRLVTTKNLDRETLSLYNITLKATDGGTPPLSRETHIFM--QVADTNDNP 412
Query: 195 KEF-----QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKLF-SLDS 248
F + I + R L H + + + +L + I G + S++S
Sbjct: 413 PTFPHSSYSVYIAENNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPVSSYVSINS 472
Query: 249 VNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF-- 306
G L+ + D + LQ L+V A +P ++ + + +LD NDN PE
Sbjct: 473 DTGVLYALQSFDYEQLRELQ-----LRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPEILY 527
Query: 307 -EVDFYNISIVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSG 359
+ + +E P G+ V +V+A DKD G+N +Y L G F++ +G
Sbjct: 528 PALPTDGSTGMELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYLLLKASEPGLFAVGLYTG 587
Query: 360 WLTVRNQTVLDREA 373
+ + +LDR+A
Sbjct: 588 EVRTA-RALLDRDA 600
Score = 45.2 bits (102), Expect = 0.002
Identities = 50/171 (29%), Positives = 78/171 (45%), Gaps = 25/171 (14%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYEN 1287
G P SSTA + VTV DV D PVF Y++ + ENV L++++ + E
Sbjct: 181 GDPPRSSTAHIQVTVVDVNDHT-----PVFSLPQYQVTVPENVPVGTRLLTVHAIDLDEG 235
Query: 1288 FKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHM 1347
+ E R+ I P+ ++ + S E+ T E + E Y E+
Sbjct: 236 ------VNGEVTYSFRK---ITPKLPKMFHLNSLTGEIS-TLEGLDYEETAFYEMEVQ-- 283
Query: 1348 IYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTTAPFG 1398
A+D +TK KV++ + DVNDN+P+ T + L ++IP P G
Sbjct: 284 ----AQDGPGSLTK--AKVLITVLDVNDNAPEVTMTS--LSSSIPEDTPLG 326
Score = 37.5 bits (83), Expect = 0.37
Identities = 38/132 (28%), Positives = 59/132 (44%), Gaps = 13/132 (9%)
Query: 436 DEQLMSFVNVEVTLLDANDNNP-VFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPD 488
D L S +++ + +LD NDN P + P S E + +S A+ G ++ KV AVD D
Sbjct: 502 DPPLSSNMSLSLFVLDQNDNPPEILYPALPTDGSTGMELAPRS-AEPGYLVTKVVAVDKD 560
Query: 489 LGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPS 546
GQN + Y L + S + F + TG V A + + + +L V D P
Sbjct: 561 SGQNAWLSYLLLKASEPGL---FAVGLYTGEVRTARALLDRDALKQSLVVAVQDHGQPPL 617
Query: 547 ERRYSLAVVTIE 558
+L V +
Sbjct: 618 SATVTLTVAVAD 629
>AL731541-3|CAI40838.1| 728|Homo sapiens cadherin-like 23 protein.
Length = 728
Score = 104 bits (249), Expect = 3e-21
Identities = 91/334 (27%), Positives = 155/334 (46%), Gaps = 24/334 (7%)
Query: 71 GAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSL 128
G G NQ + +V + + D+NDN P + D PY++ + E+TP + + + P +G +
Sbjct: 269 GVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENG 328
Query: 129 TIPLTVPRGLTIFK------DIRA----FDRDKPNTPNSDVHYSIV-SGNDDGHFALESS 177
T+ ++ + IR DR+ P+ +++ IV S D G L+++
Sbjct: 329 TLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKAT 388
Query: 178 HKPVLLLRKVLDYDAGDKEFQ-LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELI 236
+ + +LD + D FQ L +A + + AID D G+ + Y +
Sbjct: 389 SSATVFVN-LLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP 447
Query: 237 SGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
G R F ++S +G + ELD + Q L+V AS P K++ + + I +
Sbjct: 448 VGMPRMDFLINSSSGVVVTTTELDRERIAEYQ-----LRVVASDAGTPTKSSTSTLTIHV 502
Query: 297 LDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSI 354
LD+ND P F YN+S+ E++P F V+ + TD D G N E +Y + + G FS+
Sbjct: 503 LDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSV 562
Query: 355 DPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
R VR LDRE ++ + + A + P
Sbjct: 563 GYRDA--VVRTVVGLDRETTAAYMLILEAIDNGP 594
Score = 97.9 bits (233), Expect = 2e-19
Identities = 133/516 (25%), Positives = 202/516 (39%), Gaps = 65/516 (12%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN T TI EV +N + + ENI G T++ LNA DLD Y
Sbjct: 168 LNSTVPVTI-EVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSR----EYG 222
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG---N 1024
S +Y +LE F IN R G + L E SE+ L + A+DGG N
Sbjct: 223 QESIIY---------SLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHN 273
Query: 1025 LNDNI-SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYF 1083
I +V + + D+ND+ P +K Y N+ E + V A D D G+N L Y
Sbjct: 274 QKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS 333
Query: 1084 IQPSDTDLPFEISPLTG-VLSVNGELDRETEDKY------ILTVVARDNGX-XXXXXXXX 1135
IQP + + ++ TG + + + LDRE D + + V D G
Sbjct: 334 IQPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 391
Query: 1136 XXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTT 1195
D+NDN P F + E +S + ++ + + P+G
Sbjct: 392 TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMP 451
Query: 1196 VAKVFANDTDFIG------NGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEV 1249
N + + + + Y L R + G P+ SST+ L + V DV DE
Sbjct: 452 RMDFLINSSSGVVVTTTELDRERIAEYQL--RVVASDAGTPTKSSTSTLTIHVLDVNDET 509
Query: 1250 EMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV 1307
P F Y + + E+V +V LN T++ N ++ Y+I N + F
Sbjct: 510 -----PTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGN---VDGKFS 561
Query: 1308 IDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVV 1367
+ R+ + V DRE Y +I+ A PV + T V
Sbjct: 562 VGYRDAVVRTVVGLDRETTAAYMLILEAIDNG----------PVGKRHTGTAT-----VF 606
Query: 1368 VRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQ 1403
V + DVNDN P F + ++P P G+ ++Q
Sbjct: 607 VTVLDVNDNRPIFLQSS--YEASVPEDIPEGHSILQ 640
Score = 90.2 bits (214), Expect = 5e-17
Identities = 115/466 (24%), Positives = 186/466 (39%), Gaps = 34/466 (7%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V + +LD NDN P F + Y +++ N T + +++A D D N + Y + S
Sbjct: 64 VRINVLDVNDNVPTF-QKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASA 122
Query: 505 LTITSPFKINPNTGTVSVAE----SPILEGRHALFVEASDQPANPSERRYSLAVVTIEVT 560
+ G +SV+ I G L V A D NP S VTIEV
Sbjct: 123 FGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMD-AGNPPLN--STVPVTIEVF 179
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYD-LLHGYEEGVP 619
+ + P P F Y V N+ G +V + D + + +++ E
Sbjct: 180 --DENDNP--PTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ 235
Query: 620 FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTN-ATVHV--VDVNDERGVL 676
F + RSG IT L R + Y A+ + T ATV++ +D+ND
Sbjct: 236 FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTW 295
Query: 677 LKGAHSPIIFHV----KENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAI 732
+ + + + + A+ N + +Y N +F N T I
Sbjct: 296 KDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN-KFYSLN--STTGKIRT 352
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIE--DENDNPPVFEHA 790
+ ++ D + ++ R V++ + G T+++ D NDN P F++
Sbjct: 353 TH--AMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNL 410
Query: 791 TYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL-FGEGKEMFDVDENTGVVKFI 849
+ ++E G I + A D DEG N L Y + G + F ++ ++GVV
Sbjct: 411 PFVAEVLEGIPAGVSIYQ---VVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVV-VT 466
Query: 850 GDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEF 893
LDRE+ Y+L +VA D G SS + L I + D ND P F
Sbjct: 467 TTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTF 512
Score = 85.8 bits (203), Expect = 1e-15
Identities = 99/392 (25%), Positives = 156/392 (39%), Gaps = 40/392 (10%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
Q V +TLLD NDN+P + + Y ++ + + V AVDPDLG+NG ++Y
Sbjct: 274 QKTGIATVNITLLDINDNHPTWKDAPYY-INLVEMTPPDSDVTTVVAVDPDLGENGTLVY 332
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVA------ESP---ILEGRHALFVEASDQPANPSER 548
+Q + + +N TG + E+P E + V +D P +
Sbjct: 333 SIQPPNKF-----YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTD-CGRPPLK 386
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDV 606
S A V + + N D P F P+ V + G S+ Q+ D E V
Sbjct: 387 ATSSATVFVNL---LDLNDND-PTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLV 442
Query: 607 SYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVH 665
SY + G + F + SGV+ +L R Y VA S + T+H
Sbjct: 443 SYRMPVGMPR-MDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIH 501
Query: 666 VVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTG-NVR---FLIA 721
V+DVNDE P +++V S + + F + N G N F+
Sbjct: 502 VLDVNDETPTFF-----PAVYNV---SVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG 553
Query: 722 NQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVIS--GAGIYQVTIYIED 779
D + D + T LDRE Y M ++ + G + G V + + D
Sbjct: 554 GNVDGKFSVGY-RDAVVRTVVGLDRETTAAY-MLILEAIDNGPVGKRHTGTATVFVTVLD 611
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNI 811
NDN P+F ++YE + E+ G I +++
Sbjct: 612 VNDNRPIFLQSSYEASVPEDIPEGHSILQEDL 643
Score = 83.0 bits (196), Expect = 7e-15
Identities = 138/568 (24%), Positives = 224/568 (39%), Gaps = 71/568 (12%)
Query: 598 NDAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLS 657
NDA +VSY + F++++ +G+I ++ L + +A ++
Sbjct: 4 NDAGTFGEVSYFFSDDPDR---FSLDKDTGLIMLIARLDYELIQRFTLTIIA-RDGGGEE 59
Query: 658 IVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR 717
++V+DVND K A+ + ++EN ++ Q+ + +
Sbjct: 60 TTGRVRINVLDVNDNVPTFQKDAY---VGALRENEP--SVTQLVRLRATDEDSPPNNQIT 114
Query: 718 FLIANQQDVTD--DIAIAED-GTIFTQKPLDREK--RDVYRMTVIAEFNKGVISGAGIYQ 772
+ I + DI++ E G I +PLD E+ + +TV+A + G
Sbjct: 115 YSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMA-MDAGNPPLNSTVP 173
Query: 773 VTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGE 832
VTI + DENDNPP F Y ++EN G + N + E +Y+L E
Sbjct: 174 VTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL--E 231
Query: 833 GKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
G F ++ +G + LDRE K SE LI+ D
Sbjct: 232 GSTQFRINARSGEITTTS-LLDRETK----------------SEYILIVRAVDGG----- 269
Query: 893 FNQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFL-IPENIPIGTTII 951
+ N K I T T++++ + D P ++ + E P + +
Sbjct: 270 ---VGHNQKTGI-------ATVNITLLDINDNHPTWKDA----PYYINLVEMTPPDSDVT 315
Query: 952 KLNALDLDSGLNGQIRYEFNSEVYIPPSKL-SADALEVKRYFVINERHGHVIVARSLPPE 1010
+ A+D D G NG + Y PP+K S ++ K I H + P E
Sbjct: 316 TVVAVDPDLGENGTLVYSIQ-----PPNKFYSLNSTTGK----IRTTHAMLDRENPDPHE 366
Query: 1011 SEF--RLNISALDGGN--LNDNISVRVFVK--DVNDHFPVFKKTWYNFNVEEAQYTRRVL 1064
+E ++ +S D G L S VFV D+ND+ P F+ + V E +
Sbjct: 367 AELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSI 426
Query: 1065 GKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARD 1124
+V A D D G N ++Y + + F I+ +GV+ ELDRE +Y L VVA D
Sbjct: 427 YQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASD 486
Query: 1125 NGXXXXXXXXXXXXXXXXDVNDNSPKFY 1152
G DVND +P F+
Sbjct: 487 AG-TPTKSSTSTLTIHVLDVNDETPTFF 513
Score = 77.0 bits (181), Expect = 5e-13
Identities = 71/237 (29%), Positives = 104/237 (43%), Gaps = 24/237 (10%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
EN P T +++L A D DS N QI Y S +SA A YF I+ G+
Sbjct: 89 ENEPSVTQLVRLRATDEDSPPNNQITY----------SIVSASAFG--SYFDISLYEGYG 136
Query: 1002 IVARSLPPESE------FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFN 1053
+++ S P + E L + A+D GN LN + V + V D ND+ P F K Y +
Sbjct: 137 VISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVS 196
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETE 1113
V E + ++ATD D + I + F I+ +G ++ LDRET+
Sbjct: 197 VVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETK 256
Query: 1114 DKYILTVVARDNG-XXXXXXXXXXXXXXXXDVNDNSPKFY---AFDELLEWKHPEAD 1166
+YIL V A D G D+NDN P + + L+E P++D
Sbjct: 257 SEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSD 313
Score = 67.7 bits (158), Expect = 3e-10
Identities = 98/398 (24%), Positives = 168/398 (42%), Gaps = 41/398 (10%)
Query: 569 DIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGYEEGVPFAVE--E 624
++P F Y + N T + ++R D N ++Y ++ G F + E
Sbjct: 74 NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYE 133
Query: 625 RSGVITVVD--DLSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVDVNDERGVLLKGAH 681
GVI+V D + + + +A+ N L+ T+ V D ND K A+
Sbjct: 134 GYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAY 193
Query: 682 SPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAEDGTIFTQ 741
+ V+ AGA + + T++ G ++ I + + T A G I T
Sbjct: 194 --FVSVVENIMAGATVLFLNATDLDRSREYGQESI---IYSLEGSTQFRINARSGEITTT 248
Query: 742 KPLDREKRDVYRMTVIA-EFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENS 800
LDRE + Y + V A + G GI V I + D NDN P ++ A Y ++E +
Sbjct: 249 SLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMT 308
Query: 801 KIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREK--- 857
+++ + A D D G N +Y++ K + ++ TG ++ LDRE
Sbjct: 309 PPDSDV---TTVVAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTTHAMLDRENPDP 364
Query: 858 ---KIMYKLSLVARDTG----GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKL 910
++M K+ + D G +S A + + + D NDN P F + ++V L
Sbjct: 365 HEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEV-------L 417
Query: 911 NG-TAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIG 947
G AG +I +V A+D+D+ G L+ +P+G
Sbjct: 418 EGIPAGVSIYQV-----VAIDLDE-GLNGLVSYRMPVG 449
Score = 62.9 bits (146), Expect = 9e-09
Identities = 53/170 (31%), Positives = 77/170 (45%), Gaps = 8/170 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGND-RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D+D + Y ++S + F + G + LD E + L V
Sbjct: 100 LRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ-ISNGLIYLTV 158
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A NP + V IE+ D NDN P F Y +S+VEN+ G +VL + ATD D+
Sbjct: 159 MAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRS 218
Query: 337 -ENGE--FTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
E G+ Y L+ F I+ RSG +T ++LDRE S + V A
Sbjct: 219 REYGQESIIYSLEG-STQFRINARSGEIT--TTSLLDRETKSEYILIVRA 265
Score = 60.9 bits (141), Expect = 3e-08
Identities = 75/284 (26%), Positives = 115/284 (40%), Gaps = 36/284 (12%)
Query: 1069 ATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXX 1128
ATD D G ++YF SD F + TG++ + LD E ++ LT++ARD G
Sbjct: 1 ATDNDAGTFGEVSYFF--SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE 58
Query: 1129 XXXXXXXXXXXXXXDVNDNSPKFY--AFDELLEWKHPEADEL------------SNHNFE 1174
DVNDN P F A+ L P +L +N
Sbjct: 59 ETTGRVRINVL---DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITY 115
Query: 1175 SVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSS 1234
S++ + + + + G V V + D+ NGLI ++ + G P L+S
Sbjct: 116 SIVSASAFGSYFDISLYEGYGVISV-SRPLDYEQISNGLIYLTVMA----MDAGNPPLNS 170
Query: 1235 TAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTE--HYENFKMRY 1292
T + + V D E + P F Y + + EN+ A ++ LN T+ +
Sbjct: 171 TVPVTIEVFD-----ENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQES 225
Query: 1293 YILN-ENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
I + E T R I+ R+G + DRE K Y +IVRA
Sbjct: 226 IIYSLEGSTQFR----INARSGEITTTSLLDRETKSEYILIVRA 265
Score = 60.1 bits (139), Expect = 6e-08
Identities = 62/202 (30%), Positives = 89/202 (44%), Gaps = 19/202 (9%)
Query: 955 ALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFR 1014
A D D+G G++ Y F+ + P + S D + ++ R + ++ R F
Sbjct: 1 ATDNDAGTFGEVSYFFSDD----PDRFSLD--KDTGLIMLIARLDYELIQR-------FT 47
Query: 1015 LNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADF 1074
L I A DGG VR+ V DVND+ P F+K Y + E + + L ++ ATD D
Sbjct: 48 LTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDS 107
Query: 1075 GQNANLTY-FIQPSDTDLPFEISPLT--GVLSVNGELDRE--TEDKYILTVVARDNGXXX 1129
N +TY + S F+IS GV+SV+ LD E + LTV+A D G
Sbjct: 108 PPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAG-NP 166
Query: 1130 XXXXXXXXXXXXXDVNDNSPKF 1151
D NDN P F
Sbjct: 167 PLNSTVPVTIEVFDENDNPPTF 188
Score = 58.4 bits (135), Expect = 2e-07
Identities = 41/126 (32%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D G + Y DR FSLD G + L LD + F L + A
Sbjct: 1 ATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYEL-----IQRFTLTIIAR 53
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
T RV I +LD+NDN+P F+ D Y ++ EN P+ ++++ ATD+D N
Sbjct: 54 DGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNN 111
Query: 340 EFTYQL 345
+ TY +
Sbjct: 112 QITYSI 117
Score = 50.4 bits (115), Expect = 5e-05
Identities = 29/82 (35%), Positives = 44/82 (53%), Gaps = 2/82 (2%)
Query: 814 ATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGL 873
ATD D GT Y F + + F +D++TG++ I LD E + L+++ARD GG
Sbjct: 1 ATDNDAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIA-RLDYELIQRFTLTIIARDGGGE 58
Query: 874 SSEAELIIMIGDENDNKPEFNQ 895
+ + I + D NDN P F +
Sbjct: 59 ETTGRVRINVLDVNDNVPTFQK 80
Score = 49.6 bits (113), Expect = 8e-05
Identities = 65/266 (24%), Positives = 105/266 (39%), Gaps = 17/266 (6%)
Query: 73 GLNQISAYLSVTVYIE--DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLT- 129
G + A S TV++ D+NDN P F + P+ V E P G + + + L
Sbjct: 381 GRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNG 440
Query: 130 -----IPLTVPRGLTIFKDIRAFDRDKPNTPNSDV-HYSIVSGNDDGHFALESSHKPVLL 183
+P+ +PR + + Y + D +SS + +
Sbjct: 441 LVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTI 500
Query: 184 LRKVLDY-DAGDKEFQLVIMAS-GKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDR 241
VLD D F V S + + +E ++ D D+G+ A L Y + GN
Sbjct: 501 --HVLDVNDETPTFFPAVYNVSVSEDVPREFRVVW-LNCTDNDVGLNAELSYFITGGNVD 557
Query: 242 KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLND 301
FS+ + + + LD E A +L+ + T A V + +LD+ND
Sbjct: 558 GKFSVGYRDA--VVRTVVGLDRE-TTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVND 614
Query: 302 NLPEFEVDFYNISIVENLPNGFSVLQ 327
N P F Y S+ E++P G S+LQ
Sbjct: 615 NRPIFLQSSYEASVPEDIPEGHSILQ 640
Score = 44.0 bits (99), Expect = 0.004
Identities = 60/250 (24%), Positives = 103/250 (41%), Gaps = 36/250 (14%)
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTDFIGN-GNGLILYSLP-QRKNQQNLGLPSLSSTAI 1237
P Y ++ EN G TV + A D D G I+YSL + + N +++T++
Sbjct: 191 PAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSL 250
Query: 1238 LMVTVADVPDEVEMSDKPVFISRYYELEIEENVN---APVELVSLNLTEHYENFK-MRYY 1293
L + E + + I R + + N A V + L++ +++ +K YY
Sbjct: 251 L---------DRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYY 301
Query: 1294 I----LNENDTDIRRTFVIDP---RNGTL-YLVRSPDR---------EVKDTYEVIVRAE 1336
I + D+D+ +DP NGTL Y ++ P++ +++ T+ ++ R
Sbjct: 302 INLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDREN 361
Query: 1337 RQKYSRELPHMIYPVAEDVLEGMTKY--DVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTT 1394
+ EL I D K V V + D+NDN P F N P V +
Sbjct: 362 PDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ--NLPFVAEVLEG 419
Query: 1395 APFGYQVMQL 1404
P G + Q+
Sbjct: 420 IPAGVSIYQV 429
Score = 33.5 bits (73), Expect = 6.0
Identities = 16/45 (35%), Positives = 25/45 (55%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTP 111
+V AG S+ ++T+++ DVND P F Y+V+V E P
Sbjct: 482 VVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVP 526
>AB058715-1|BAB47441.1| 803|Homo sapiens KIAA1812 protein protein.
Length = 803
Score = 104 bits (249), Expect = 3e-21
Identities = 91/334 (27%), Positives = 155/334 (46%), Gaps = 24/334 (7%)
Query: 71 GAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPT-GEKAFIFLIAP-IGPSL 128
G G NQ + +V + + D+NDN P + D PY++ + E+TP + + + P +G +
Sbjct: 343 GVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENG 402
Query: 129 TIPLTVPRGLTIFK------DIRA----FDRDKPNTPNSDVHYSIV-SGNDDGHFALESS 177
T+ ++ + IR DR+ P+ +++ IV S D G L+++
Sbjct: 403 TLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKAT 462
Query: 178 HKPVLLLRKVLDYDAGDKEFQ-LVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELI 236
+ + +LD + D FQ L +A + + AID D G+ + Y +
Sbjct: 463 SSATVFVN-LLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP 521
Query: 237 SGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
G R F ++S +G + ELD + Q L+V AS P K++ + + I +
Sbjct: 522 VGMPRMDFLINSSSGVVVTTTELDRERIAEYQ-----LRVVASDAGTPTKSSTSTLTIHV 576
Query: 297 LDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSI 354
LD+ND P F YN+S+ E++P F V+ + TD D G N E +Y + + G FS+
Sbjct: 577 LDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSV 636
Query: 355 DPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
R VR LDRE ++ + + A + P
Sbjct: 637 GYRDA--VVRTVVGLDRETTAAYMLILEAIDNGP 668
Score = 97.9 bits (233), Expect = 2e-19
Identities = 133/516 (25%), Positives = 202/516 (39%), Gaps = 65/516 (12%)
Query: 910 LNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYE 969
LN T TI EV +N + + ENI G T++ LNA DLD Y
Sbjct: 242 LNSTVPVTI-EVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSR----EYG 296
Query: 970 FNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG---N 1024
S +Y +LE F IN R G + L E SE+ L + A+DGG N
Sbjct: 297 QESIIY---------SLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHN 347
Query: 1025 LNDNI-SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYF 1083
I +V + + D+ND+ P +K Y N+ E + V A D D G+N L Y
Sbjct: 348 QKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS 407
Query: 1084 IQPSDTDLPFEISPLTG-VLSVNGELDRETEDKY------ILTVVARDNGX-XXXXXXXX 1135
IQP + + ++ TG + + + LDRE D + + V D G
Sbjct: 408 IQPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 465
Query: 1136 XXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTT 1195
D+NDN P F + E +S + ++ + + P+G
Sbjct: 466 TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMP 525
Query: 1196 VAKVFANDTDFIG------NGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEV 1249
N + + + + Y L R + G P+ SST+ L + V DV DE
Sbjct: 526 RMDFLINSSSGVVVTTTELDRERIAEYQL--RVVASDAGTPTKSSTSTLTIHVLDVNDET 583
Query: 1250 EMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV 1307
P F Y + + E+V +V LN T++ N ++ Y+I N + F
Sbjct: 584 -----PTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGN---VDGKFS 635
Query: 1308 IDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVV 1367
+ R+ + V DRE Y +I+ A PV + T V
Sbjct: 636 VGYRDAVVRTVVGLDRETTAAYMLILEAIDNG----------PVGKRHTGTAT-----VF 680
Query: 1368 VRIKDVNDNSPKFTNGNRPLVTAIPTTAPFGYQVMQ 1403
V + DVNDN P F + ++P P G+ ++Q
Sbjct: 681 VTVLDVNDNRPIFLQSS--YEASVPEDIPEGHSILQ 714
Score = 95.1 bits (226), Expect = 2e-18
Identities = 131/529 (24%), Positives = 222/529 (41%), Gaps = 58/529 (10%)
Query: 440 MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
+ + V++TL++ NDN P+F LY S+ N VGT + V A D D G G V Y
Sbjct: 32 VGYAKVKITLINENDNRPIF-SQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVNYFF 90
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVVTI 557
+ F ++ +TG + + E R L + A D + R + V+ +
Sbjct: 91 SDDPD-----RFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDV 145
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYE 615
++P F Y + N T + ++R D+ N ++Y ++
Sbjct: 146 ---------NDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASA 196
Query: 616 EGVPFAVE--ERSGVITVVD--DLSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVDVN 670
G F + E GVI+V D + + + +A+ N L+ T+ V D N
Sbjct: 197 FGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDEN 256
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
D K A+ + V+ AGA + + T++ G ++ I + + T
Sbjct: 257 DNPPTFSKPAY--FVSVVENIMAGATVLFLNATDLDRSREYGQESI---IYSLEGSTQFR 311
Query: 731 AIAEDGTIFTQKPLDREKRDVYRMTVIA-EFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
A G I T LDRE + Y + V A + G GI V I + D NDN P ++
Sbjct: 312 INARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKD 371
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFI 849
A Y ++E + +++ + A D D G N +Y++ K + ++ TG ++
Sbjct: 372 APYYINLVEMTPPDSDV---TTVVAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTT 427
Query: 850 GDSLDREK------KIMYKLSLVARDTG----GLSSEAELIIMIGDENDNKPEFNQIEEN 899
LDRE ++M K+ + D G +S A + + + D NDN P F +
Sbjct: 428 HAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFV 487
Query: 900 SKVRIHRETKLNG-TAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIG 947
++V L G AG +I +V A+D+D+ G L+ +P+G
Sbjct: 488 AEV-------LEGIPAGVSIYQV-----VAIDLDE-GLNGLVSYRMPVG 523
Score = 94.3 bits (224), Expect = 3e-18
Identities = 123/436 (28%), Positives = 180/436 (41%), Gaps = 69/436 (15%)
Query: 743 PLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKI 802
PLD E D Y + A N+ V G +V I + +ENDN P+F Y + EN +
Sbjct: 9 PLDYETVDRYDFDLFA--NESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTV 66
Query: 803 GTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYK 862
GT + + ATD D GT FGE F D + +F SLD+
Sbjct: 67 GTSVLT---VLATDNDAGT--------FGEVNYFFSDDPD----RF---SLDK------- 101
Query: 863 LSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVK 922
DTG LI++I + ++ I+ + I R+ T G I V
Sbjct: 102 ------DTG-------LIMLIA-----RLDYELIQRFTLTIIARDGGGEETTGRVRINVL 143
Query: 923 PKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLS 982
N + + + EN P T +++L A D DS N QI Y S +S
Sbjct: 144 DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITY----------SIVS 193
Query: 983 ADALEVKRYFVINERHGHVIVARSLPPESE------FRLNISALDGGN--LNDNISVRVF 1034
A A YF I+ G+ +++ S P + E L + A+D GN LN + V +
Sbjct: 194 ASAFG--SYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 251
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFE 1094
V D ND+ P F K Y +V E + ++ATD D + I + F
Sbjct: 252 VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFR 311
Query: 1095 ISPLTGVLSVNGELDRETEDKYILTVVARDNG-XXXXXXXXXXXXXXXXDVNDNSPKFY- 1152
I+ +G ++ LDRET+ +YIL V A D G D+NDN P +
Sbjct: 312 INARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKD 371
Query: 1153 --AFDELLEWKHPEAD 1166
+ L+E P++D
Sbjct: 372 APYYINLVEMTPPDSD 387
Score = 89.0 bits (211), Expect = 1e-16
Identities = 146/597 (24%), Positives = 236/597 (39%), Gaps = 73/597 (12%)
Query: 571 PDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYEEGVPFAVEERSGV 628
P F Y + NV +GTSV + NDA +V+Y + F++++ +G+
Sbjct: 49 PIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVNYFFSDDPDR---FSLDKDTGL 105
Query: 629 ITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHV 688
I ++ L + +A ++ ++V+DVND K A+ + +
Sbjct: 106 IMLIARLDYELIQRFTLTIIA-RDGGGEETTGRVRINVLDVNDNVPTFQKDAY---VGAL 161
Query: 689 KENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTD--DIAIAED-GTIFTQKPLD 745
+EN ++ Q+ + + + I + DI++ E G I +PLD
Sbjct: 162 RENEP--SVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLD 219
Query: 746 REK--RDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIG 803
E+ + +TV+A + G VTI + DENDNPP F Y ++EN G
Sbjct: 220 YEQISNGLIYLTVMA-MDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAG 278
Query: 804 TEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKL 863
+ N + E +Y+L EG F ++ +G + LDRE K
Sbjct: 279 ATVLFLNATDLDRSREYGQESIIYSL--EGSTQFRINARSGEITTTS-LLDRETK----- 330
Query: 864 SLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAGFTIIEVKP 923
SE LI+ D + N K I T T++++
Sbjct: 331 -----------SEYILIVRAVDGG--------VGHNQKTGI-------ATVNITLLDIND 364
Query: 924 KNKFALDVDQLGPLFL-IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL- 981
+ D P ++ + E P + + + A+D D G NG + Y PP+K
Sbjct: 365 NHPTWKDA----PYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ-----PPNKFY 415
Query: 982 SADALEVKRYFVINERHGHVIVARSLPPESEF--RLNISALDGGN--LNDNISVRVFVK- 1036
S ++ K I H + P E+E ++ +S D G L S VFV
Sbjct: 416 SLNSTTGK----IRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNL 471
Query: 1037 -DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI 1095
D+ND+ P F+ + V E + +V A D D G N ++Y + + F I
Sbjct: 472 LDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLI 531
Query: 1096 SPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY 1152
+ +GV+ ELDRE +Y L VVA D G DVND +P F+
Sbjct: 532 NSSSGVVVTTTELDRERIAEYQLRVVASDAG-TPTKSSTSTLTIHVLDVNDETPTFF 587
Score = 84.6 bits (200), Expect = 2e-15
Identities = 99/387 (25%), Positives = 153/387 (39%), Gaps = 40/387 (10%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
Q V +TLLD NDN+P + + Y ++ + + V AVDPDLG+NG ++Y
Sbjct: 348 QKTGIATVNITLLDINDNHPTWKDAPYY-INLVEMTPPDSDVTTVVAVDPDLGENGTLVY 406
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVA------ESP---ILEGRHALFVEASDQPANPSER 548
+Q + + +N TG + E+P E + V +D P +
Sbjct: 407 SIQPPNKF-----YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTD-CGRPPLK 460
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDV 606
S A V + + N D P F P+ V + G S+ Q+ D E V
Sbjct: 461 ATSSATVFVNL---LDLNDND-PTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLV 516
Query: 607 SYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENA-NLSIVTNATVH 665
SY + G + F + SGV+ +L R Y VA S + T+H
Sbjct: 517 SYRMPVGMPR-MDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIH 575
Query: 666 VVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTG-NVR---FLIA 721
V+DVNDE P +++V S + + F + N G N F+
Sbjct: 576 VLDVNDETPTFF-----PAVYNV---SVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG 627
Query: 722 NQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVIS--GAGIYQVTIYIED 779
D + D + T LDRE Y M ++ + G + G V + + D
Sbjct: 628 GNVDGKFSVGY-RDAVVRTVVGLDRETTAAY-MLILEAIDNGPVGKRHTGTATVFVTVLD 685
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEI 806
NDN P+F ++YE + E+ G I
Sbjct: 686 VNDNRPIFLQSSYEASVPEDIPEGHSI 712
Score = 72.9 bits (171), Expect = 8e-12
Identities = 84/322 (26%), Positives = 133/322 (41%), Gaps = 36/322 (11%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTD 1090
V++ + + ND+ P+F + YN ++ E + V ATD D G + YF SD
Sbjct: 37 VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVNYFF--SDDP 94
Query: 1091 LPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
F + TG++ + LD E ++ LT++ARD G DVNDN P
Sbjct: 95 DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG---GEETTGRVRINVLDVNDNVPT 151
Query: 1151 FY--AFDELLEWKHPEADEL------------SNHNFESVMMIPVYKATIEENAPIGTTV 1196
F A+ L P +L +N S++ + + + + G V
Sbjct: 152 FQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGV 211
Query: 1197 AKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPV 1256
V + D+ NGLI ++ + G P L+ST + + V D E + P
Sbjct: 212 ISV-SRPLDYEQISNGLIYLTV----MAMDAGNPPLNSTVPVTIEVFD-----ENDNPPT 261
Query: 1257 FISRYYELEIEENVNAPVELVSLNLT--EHYENFKMRYYILN-ENDTDIRRTFVIDPRNG 1313
F Y + + EN+ A ++ LN T + + I + E T R I+ R+G
Sbjct: 262 FSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFR----INARSG 317
Query: 1314 TLYLVRSPDREVKDTYEVIVRA 1335
+ DRE K Y +IVRA
Sbjct: 318 EITTTSLLDRETKSEYILIVRA 339
Score = 66.1 bits (154), Expect = 9e-10
Identities = 38/102 (37%), Positives = 54/102 (52%), Gaps = 2/102 (1%)
Query: 284 PLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTY 343
P A+V+I L++ NDN P F YNIS+ EN+ G SVL V+ATD D G GE Y
Sbjct: 29 PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVNY 88
Query: 344 QLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
D FS+D +G + + + LD E + + A++
Sbjct: 89 FFSDDPDRFSLDKDTGLIMLIAR--LDYELIQRFTLTIIARD 128
Score = 62.9 bits (146), Expect = 9e-09
Identities = 53/170 (31%), Positives = 77/170 (45%), Gaps = 8/170 (4%)
Query: 218 IHAIDQDLGVGATLRYELISGND-RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A D+D + Y ++S + F + G + LD E + L V
Sbjct: 174 LRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ-ISNGLIYLTV 232
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A NP + V IE+ D NDN P F Y +S+VEN+ G +VL + ATD D+
Sbjct: 233 MAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRS 292
Query: 337 -ENGE--FTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
E G+ Y L+ F I+ RSG +T ++LDRE S + V A
Sbjct: 293 REYGQESIIYSLEG-STQFRINARSGEIT--TTSLLDRETKSEYILIVRA 339
Score = 58.8 bits (136), Expect = 1e-07
Identities = 41/126 (32%), Positives = 59/126 (46%), Gaps = 9/126 (7%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D G + Y DR FSLD G + L LD + F L + A
Sbjct: 75 ATDNDAGTFGEVNYFFSDDPDR--FSLDKDTGLIMLIARLDYEL-----IQRFTLTIIAR 127
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
T RV I +LD+NDN+P F+ D Y ++ EN P+ ++++ ATD+D N
Sbjct: 128 DGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNN 185
Query: 340 EFTYQL 345
+ TY +
Sbjct: 186 QITYSI 191
Score = 49.6 bits (113), Expect = 8e-05
Identities = 65/266 (24%), Positives = 105/266 (39%), Gaps = 17/266 (6%)
Query: 73 GLNQISAYLSVTVYIE--DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLT- 129
G + A S TV++ D+NDN P F + P+ V E P G + + + L
Sbjct: 455 GRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNG 514
Query: 130 -----IPLTVPRGLTIFKDIRAFDRDKPNTPNSDV-HYSIVSGNDDGHFALESSHKPVLL 183
+P+ +PR + + Y + D +SS + +
Sbjct: 515 LVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTI 574
Query: 184 LRKVLDY-DAGDKEFQLVIMAS-GKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDR 241
VLD D F V S + + +E ++ D D+G+ A L Y + GN
Sbjct: 575 --HVLDVNDETPTFFPAVYNVSVSEDVPREFRVVW-LNCTDNDVGLNAELSYFITGGNVD 631
Query: 242 KLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLND 301
FS+ + + + LD E A +L+ + T A V + +LD+ND
Sbjct: 632 GKFSVGYRDA--VVRTVVGLDRE-TTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVND 688
Query: 302 NLPEFEVDFYNISIVENLPNGFSVLQ 327
N P F Y S+ E++P G S+LQ
Sbjct: 689 NRPIFLQSSYEASVPEDIPEGHSILQ 714
Score = 44.0 bits (99), Expect = 0.004
Identities = 60/250 (24%), Positives = 103/250 (41%), Gaps = 36/250 (14%)
Query: 1180 PVYKATIEENAPIGTTVAKVFANDTDFIGN-GNGLILYSLP-QRKNQQNLGLPSLSSTAI 1237
P Y ++ EN G TV + A D D G I+YSL + + N +++T++
Sbjct: 265 PAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSL 324
Query: 1238 LMVTVADVPDEVEMSDKPVFISRYYELEIEENVN---APVELVSLNLTEHYENFK-MRYY 1293
L + E + + I R + + N A V + L++ +++ +K YY
Sbjct: 325 L---------DRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYY 375
Query: 1294 I----LNENDTDIRRTFVIDP---RNGTL-YLVRSPDR---------EVKDTYEVIVRAE 1336
I + D+D+ +DP NGTL Y ++ P++ +++ T+ ++ R
Sbjct: 376 INLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDREN 435
Query: 1337 RQKYSRELPHMIYPVAEDVLEGMTKY--DVKVVVRIKDVNDNSPKFTNGNRPLVTAIPTT 1394
+ EL I D K V V + D+NDN P F N P V +
Sbjct: 436 PDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ--NLPFVAEVLEG 493
Query: 1395 APFGYQVMQL 1404
P G + Q+
Sbjct: 494 IPAGVSIYQV 503
Score = 33.5 bits (73), Expect = 6.0
Identities = 16/45 (35%), Positives = 25/45 (55%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTP 111
+V AG S+ ++T+++ DVND P F Y+V+V E P
Sbjct: 556 VVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVP 600
>AB053445-1|BAB61902.1| 1147|Homo sapiens KIAA1774 protein protein.
Length = 1147
Score = 104 bits (249), Expect = 3e-21
Identities = 136/528 (25%), Positives = 222/528 (42%), Gaps = 51/528 (9%)
Query: 390 VVGTFADSQRIAKWRRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTL 449
++G + ++ W + +P+ + + + +N E+ +S N ++T+
Sbjct: 50 ILGGSSQAEPGLVWSTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTV 109
Query: 450 --LDANDNNPVFVPSNL--YEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNL 505
LD NDN P F P + Y + A GT + V AVDPD G NG+V Y L L
Sbjct: 110 NVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTL-----L 164
Query: 506 TITSPFKI---NPNTGTVSVAESPILEGRHAL--FVEASDQPANPSERRYSLAVVTIEVT 560
+ P + + + G V + E H L V ASD N S R + V +E+
Sbjct: 165 DLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASD---NGSPPRAAEIPVYLEIV 221
Query: 561 RGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPF 620
N P F Y+ V +V +GT + + DA N + G E F
Sbjct: 222 DINDNN----PIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGES-KF 276
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSI-----VTNATVHVVDVNDERGV 675
A+ +G I V+ L R + Y A+A +++ + V+DVND R
Sbjct: 277 AINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQ 336
Query: 676 LLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAED 735
K S ++ + AG ++ + T+ G + + + + + +
Sbjct: 337 FSKPQFSTSVY--ENEPAGTSVITMMATDQDE---GPNGELTYSLEGPGVEAFHVDM-DS 390
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G + TQ+PL + + + +TV+A + G G + + + D NDN PVF G
Sbjct: 391 GLVTTQRPL--QSYEKFSLTVVAT-DGGEPPLWGTTMLLVEVIDVNDNRPVFVRPP-NGT 446
Query: 796 IMENSKIGTEIKM-DNI--IKATDADEGTNAL----FMYTLFGEGKEMFDVDENTGVVKF 848
I+ I EI + N+ + ATD DEG N F+ T E F +D +G+++
Sbjct: 447 ILH---IREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQ- 502
Query: 849 IGDSLDREKKIMYKLSLVARDTG---GLSSEAELIIMIGDENDNKPEF 893
LDRE + +Y L LVA D G + L + + D +DN+P F
Sbjct: 503 TAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLF 550
Score = 97.9 bits (233), Expect = 2e-19
Identities = 125/494 (25%), Positives = 202/494 (40%), Gaps = 69/494 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I E GTT+I + A+D D GLNG + Y +PP + + + G
Sbjct: 133 ILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLD--LVPPGYVQLE----------DSSAG 180
Query: 1000 HVIVARSLPPESEFRLN--ISALDGGNLNDNISVRVFVK--DVNDHFPVFKKTWYNFNVE 1055
VI R++ E LN + A D G+ + V+++ D+ND+ P+F + Y V
Sbjct: 181 KVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVF 240
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E ++ V ATDAD G A + Y + D + F I+P TG + V LDRE +D
Sbjct: 241 EDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLDREKKDH 298
Query: 1116 YILTVVARDNG---XXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHN 1172
YILT +A+DN DVND P+F P+ N
Sbjct: 299 YILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQF---------SKPQFSTSVYEN 349
Query: 1173 FESVMMIPVYKATIEENAPIGTTVAKVFANDTD--FIGNGNGLILYSLPQRKNQQ----- 1225
+ + AT ++ P G + + + +GL+ P + ++
Sbjct: 350 EPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTV 409
Query: 1226 ---NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFI--SRYYELEIEENVNAPVELVSLN 1280
+ G P L T +L+V V DV D ++PVF+ L I E + + +
Sbjct: 410 VATDGGEPPLWGTTMLLVEVIDVND-----NRPVFVRPPNGTILHIREEIPLRSNVYEVY 464
Query: 1281 LTEHYE--NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
T+ E N +RY L F+IDP +G + + DRE + Y +I+ A
Sbjct: 465 ATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS-- 522
Query: 1339 KYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT----NGNRPLVTAIPTT 1394
+ PV + ++ + V ++D++DN P F + + +P
Sbjct: 523 -------DLGQPVPYETMQPLQ-------VALEDIDDNEPLFVRPPKGSPQYQLLTVPEH 568
Query: 1395 APFGYQVMQLKGAI 1408
+P G V + GA+
Sbjct: 569 SPRGTLVGNVTGAV 582
Score = 87.8 bits (208), Expect = 3e-16
Identities = 74/253 (29%), Positives = 114/253 (45%), Gaps = 20/253 (7%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
+ +VD+ND + + ++ +F ++ G I + T+ S GN + +
Sbjct: 218 LEIVDINDNNPIFDQPSYQEAVF--EDVPVGTIILTVTATDADS------GNFALIEYSL 269
Query: 724 QDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG---AGIYQVTIYIED 779
D AI G I+ LDREK+D Y +T +A+ N G ++ QV I + D
Sbjct: 270 GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLD 329
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDV 839
ND P F + + EN GT + + ATD DEG N Y+L G G E F V
Sbjct: 330 VNDCRPQFSKPQFSTSVYENEPAGTSVIT---MMATDQDEGPNGELTYSLEGPGVEAFHV 386
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIE 897
D ++G+V EK + L++VA D G L L++ + D NDN+P F +
Sbjct: 387 DMDSGLVTTQRPLQSYEK---FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPP 443
Query: 898 ENSKVRIHRETKL 910
+ + I E L
Sbjct: 444 NGTILHIREEIPL 456
Score = 81.4 bits (192), Expect = 2e-14
Identities = 113/492 (22%), Positives = 204/492 (41%), Gaps = 54/492 (10%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + +LD ND P F + S+ N GT + + A D D G NG + Y L+
Sbjct: 321 VQVVIQVLDVNDCRPQFSKPQ-FSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGP 379
Query: 503 SNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F ++ ++G V+ + +L V A+D P L V I+V
Sbjct: 380 G----VEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVN-- 433
Query: 563 TKGNKPDIPDFMGAPYE--FWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLH--GYEE 616
N+P F+ P + + + ++V ++ D E V Y L G +
Sbjct: 434 --DNRPV---FVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRD 488
Query: 617 GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV--DVNDERG 674
F ++ SG+I L R ++ +Y VA + T + V D++D
Sbjct: 489 WEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEP 548
Query: 675 VLL---KGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
+ + KG+ + V E+S G +G + + + G F+ A ++ +
Sbjct: 549 LFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGA-VDADEGPNAIVYYFIAAGNEE--KNF 605
Query: 731 AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKG------------VISGAGIYQVTIYIE 778
+ DG + + LDRE+ ++ V A N+ +++ + +V + +E
Sbjct: 606 HLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLE 665
Query: 779 DENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG--EGKEM 836
D ND PP F A Y + ++K+G+E+ + A DAD G N+L Y++ + +
Sbjct: 666 DINDQPPRFTKAEYTAGVATDAKVGSELIQ---VLALDADIGNNSLVFYSILAIHYFRAL 722
Query: 837 FDVDENTGVVKFIG--DSLDREKKIM-------YKLSLVARDTGGLSSEAEL-IIMIGDE 886
+ E+ G V +G D + R + + + +VARD G + A + I ++ D+
Sbjct: 723 ANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDD 782
Query: 887 NDNKPEFNQIEE 898
K N+I +
Sbjct: 783 QRVKIVINEIPD 794
Score = 80.6 bits (190), Expect = 4e-14
Identities = 47/148 (31%), Positives = 78/148 (52%), Gaps = 4/148 (2%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G A + Y L G + F+++ G +++ LD + + +
Sbjct: 252 VTATDADSGNFALIEYSLGDGESK--FAINPTTGDIYVLSSLDREKKDHYILTALAKDNP 309
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
+N + + +V I++LD+ND P+F ++ S+ EN P G SV+ +MATD+D+G
Sbjct: 310 GDVASNRRENS-VQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGP 368
Query: 338 NGEFTYQLDDP-KGAFSIDPRSGWLTVR 364
NGE TY L+ P AF +D SG +T +
Sbjct: 369 NGELTYSLEGPGVEAFHVDMDSGLVTTQ 396
Score = 80.2 bits (189), Expect = 5e-14
Identities = 128/492 (26%), Positives = 206/492 (41%), Gaps = 65/492 (13%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
E++P+GT I+ + A D DSG I Y E K F IN G +
Sbjct: 241 EDVPVGTIILTVTATDADSGNFALIEYSLGDG-------------ESK--FAINPTTGDI 285
Query: 1002 IVARSLPPESEFRLNISALDGGNLND--------NISVRVFVKDVNDHFPVFKKTWYNFN 1053
V SL E + ++AL N D ++ V + V DVND P F K ++ +
Sbjct: 286 YVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTS 345
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETE 1113
V E + + + ATD D G N LTY ++ + F + +G+++ L ++
Sbjct: 346 VYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA-FHVDMDSGLVTTQRPL--QSY 402
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNF 1173
+K+ LTVVA D G DVNDN P F E L ++ +
Sbjct: 403 EKFSLTVVATDGGEPPLWGTTMLLVEVI-DVNDNRPVFVRPPNGTILHIREEIPLRSNVY 461
Query: 1174 ESVMMIPVYKATIEE--NAPIGTTVAKVFAN-DTDF--IGNGNGLILYSLPQRKNQQ--- 1225
E VY +E N + + K N D +F I +GLI + + Q
Sbjct: 462 E------VYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY 515
Query: 1226 -------NLGLPSLSSTAI-LMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELV 1277
+LG P T L V + D+ D + +P S Y+L + ++P +
Sbjct: 516 SLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQL-LTVPEHSPRGTL 574
Query: 1278 SLNLT-----EHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVI 1332
N+T + N + Y+I N+ + F + P +G L ++R DRE + + I
Sbjct: 575 VGNVTGAVDADEGPNAIVYYFIAAGNE---EKNFHLQP-DGCLLVLRDLDREREAIFSFI 630
Query: 1333 VRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIP 1392
V+A + S P P D++ +T +V+VV ++D+ND P+FT +
Sbjct: 631 VKASSNR-SWTPPRGPSPTL-DLVADLTLQEVRVV--LEDINDQPPRFTKAE--YTAGVA 684
Query: 1393 TTAPFGYQVMQL 1404
T A G +++Q+
Sbjct: 685 TDAKVGSELIQV 696
Score = 77.8 bits (183), Expect = 3e-13
Identities = 54/177 (30%), Positives = 86/177 (48%), Gaps = 9/177 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSL-DSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A+D D G+ + Y L+ L DS G + + +D + H L V
Sbjct: 146 VAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLN-----FTV 200
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+AS +P + A+ V +E++D+NDN P F+ Y ++ E++P G +L V ATD D G
Sbjct: 201 RASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSG 260
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
Y L D + F+I+P +G + V + LDRE + AK+ NP V +
Sbjct: 261 NFALIEYSLGDGESKFAINPTTGDIYVLSS--LDREKKDHYILTALAKD-NPGDVAS 314
Score = 74.5 bits (175), Expect = 3e-12
Identities = 73/237 (30%), Positives = 105/237 (44%), Gaps = 28/237 (11%)
Query: 929 LDVDQLGPLFLIP-------ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LDV+ P F P EN P GT++I + A D D G NG++ Y L
Sbjct: 328 LDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTY-----------SL 376
Query: 982 SADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVKDVN 1039
+E F ++ G V R L +F L + A DGG L + V V DVN
Sbjct: 377 EGPGVEA---FHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVN 433
Query: 1040 DHFPVFKK--TWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPS-DTDLP-FE 1094
D+ PVF + ++ E R + +V ATD D G N + Y F++ + + D F
Sbjct: 434 DNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFI 493
Query: 1095 ISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
I P++G++ LDRE++ Y L +VA D G D++DN P F
Sbjct: 494 IDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLF 550
Score = 61.7 bits (143), Expect = 2e-08
Identities = 59/203 (29%), Positives = 92/203 (45%), Gaps = 23/203 (11%)
Query: 935 GPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVI 994
G + I E IP+ + + ++ A D D GLNG +RY F L +F+I
Sbjct: 445 GTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSF----------LKTAGNRDWEFFII 494
Query: 995 NERHGHVIVARSLPPESE--FRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFKK-- 1047
+ G + A+ L ES+ + L + A D G ++V ++D++D+ P+F +
Sbjct: 495 DPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPP 554
Query: 1048 ----TWYNFNVEEAQYTRRVLGKV-DATDADFGQNANLTYFIQPSDTDLPFEISPLTGVL 1102
+ V E ++G V A DAD G NA + YFI + + F + P G L
Sbjct: 555 KGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCL 613
Query: 1103 SVNGELDRETEDKYILTVVARDN 1125
V +LDRE E + V A N
Sbjct: 614 LVLRDLDREREAIFSFIVKASSN 636
Score = 58.4 bits (135), Expect = 2e-07
Identities = 114/498 (22%), Positives = 199/498 (39%), Gaps = 50/498 (10%)
Query: 83 VTVYIE--DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI--APIGPSLTIPLTVPRGL 138
+ VY+E D+NDN PIF Y V E P G A G I ++ G
Sbjct: 214 IPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGE 273
Query: 139 TIFK------DI---RAFDRDKPNTPNSDVHYSI--VSGNDDGHFALESSHKPVLLLRKV 187
+ F DI + DR+K + HY + ++ ++ G A V ++ +V
Sbjct: 274 SKFAINPTTGDIYVLSSLDREKKD------HYILTALAKDNPGDVASNRRENSVQVVIQV 327
Query: 188 LDYDAGDKEFQLVIMASGKRIHKEI-LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSL 246
LD + +F ++ ++ + A DQD G L Y L G + F +
Sbjct: 328 LDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHV 386
Query: 247 DSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF 306
D +G + ++ L F L V A+ P + +E++D+NDN P F
Sbjct: 387 DMDSGLVTTQRPLQ-------SYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVF 439
Query: 307 --EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKG-----AFSIDPRSG 359
+ + I E +P +V +V ATDKD+G NG Y G F IDP SG
Sbjct: 440 VRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISG 499
Query: 360 WLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGTFADSQRIAKWRRQPLETNAPLEKTTY 419
+ + LDRE+ + + + A + V ++A + ++ N PL +
Sbjct: 500 LIQTAQR--LDRESQAVYSLILVASDLGQPVPYETMQPLQVA---LEDIDDNEPL----F 550
Query: 420 VFPDKVGTKTENIEYYDEQLMSFVNVEVT-LLDANDNNPVFVPSNLYEFSMKSNAKVGTV 478
V P K + + + + + VT +DA++ V + + + N +
Sbjct: 551 VRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD 610
Query: 479 IGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEA 538
+ D D + + + ++ +SN + T P +P T+ + L+ + +
Sbjct: 611 GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSP---TLDLVADLTLQEVRVVLEDI 667
Query: 539 SDQPANPSERRYSLAVVT 556
+DQP ++ Y+ V T
Sbjct: 668 NDQPPRFTKAEYTAGVAT 685
Score = 58.0 bits (134), Expect = 2e-07
Identities = 36/146 (24%), Positives = 69/146 (47%), Gaps = 5/146 (3%)
Query: 234 ELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVE 293
+++ G+ + L GS+ ++ ++ + + V+ + + A++
Sbjct: 49 QILGGSSQAEPGLVWSTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLT 108
Query: 294 IELLDLNDNLPEFE---VDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD--P 348
+ +LD+NDN P+F+ + +Y I+E G +++ V A D D+G NG TY L D P
Sbjct: 109 VNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVP 168
Query: 349 KGAFSIDPRSGWLTVRNQTVLDREAH 374
G ++ S + N+TV E H
Sbjct: 169 PGYVQLEDSSAGKVIANRTVDYEEVH 194
Score = 50.8 bits (116), Expect = 4e-05
Identities = 46/170 (27%), Positives = 77/170 (45%), Gaps = 13/170 (7%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIY----QVTIYIEDENDNPPVFEH-- 789
G++ + P++RE Y +T+ N + + ++T+ + D NDN P F+
Sbjct: 66 GSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFG 125
Query: 790 -ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
Y I+E + GT + + A D D+G N L YTL + E++ K
Sbjct: 126 ITYYMERILEGATPGTTLIA---VAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKV 182
Query: 849 IGD-SLDREKKIMYKLSLVARDTGGLSSEAELIIM--IGDENDNKPEFNQ 895
I + ++D E+ ++ A D G AE+ + I D NDN P F+Q
Sbjct: 183 IANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQ 232
Score = 49.2 bits (112), Expect = 1e-04
Identities = 79/323 (24%), Positives = 135/323 (41%), Gaps = 34/323 (10%)
Query: 81 LSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIA--PIGPS--LTIPLTVP- 135
+ V + + DVND P F + +V E P G + GP+ LT L P
Sbjct: 321 VQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPG 380
Query: 136 -RGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
+ D +P ++V+ D G L + +LL +V+D +
Sbjct: 381 VEAFHVDMDSGLVTTQRPLQSYEKFSLTVVA-TDGGEPPLWGT---TMLLVEVIDVNDNR 436
Query: 195 KEFQLVIMASGKRIHKEILFPE---PIHAIDQDLGVGATLRYELI--SGN-DRKLFSLDS 248
F + I +EI ++A D+D G+ +RY + +GN D + F +D
Sbjct: 437 PVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDP 496
Query: 249 VNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPL--KTAQARVEIELLDLNDNLPEF 306
++G + + LD +++ + L + AS L P+ +T Q +++ L D++DN P F
Sbjct: 497 ISGLIQTAQRLDRESQ-----AVYSLILVASDLGQPVPYETMQP-LQVALEDIDDNEPLF 550
Query: 307 ------EVDFYNISIVENLPNGFSVLQVM-ATDKDQGENGEFTYQL--DDPKGAFSIDPR 357
+ +++ E+ P G V V A D D+G N Y + + + F + P
Sbjct: 551 VRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP- 609
Query: 358 SGWLTVRNQTVLDREAHSSLRMK 380
G L V +REA S +K
Sbjct: 610 DGCLLVLRDLDREREAIFSFIVK 632
Score = 45.2 bits (102), Expect = 0.002
Identities = 35/137 (25%), Positives = 61/137 (44%), Gaps = 15/137 (10%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G A + Y + +GN+ K F L +G L + ++LD + E +F+++ ++
Sbjct: 581 AVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIF---SFIVKASSN 636
Query: 280 QLNNPLKTAQA-----------RVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQV 328
+ P + V + L D+ND P F Y + + G ++QV
Sbjct: 637 RSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQV 696
Query: 329 MATDKDQGENGEFTYQL 345
+A D D G N Y +
Sbjct: 697 LALDADIGNNSLVFYSI 713
Score = 40.7 bits (91), Expect = 0.039
Identities = 58/199 (29%), Positives = 75/199 (37%), Gaps = 41/199 (20%)
Query: 1028 NISVRVFVKDVNDHFPVFKK---TWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
N + V V DVND+ P FK T+Y + E L V A D D G N +TY
Sbjct: 104 NAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTL 163
Query: 1083 --FIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXX 1140
+ P L G + N +D E TV A DNG
Sbjct: 164 LDLVPPGYVQLE---DSSAGKVIANRTVDYEEVHWLNFTVRASDNG-SPPRAAEIPVYLE 219
Query: 1141 XXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVF 1200
D+NDN+P FD+ P Y+ + E+ P+GT + V
Sbjct: 220 IVDINDNNP---IFDQ-----------------------PSYQEAVFEDVPVGTIILTVT 253
Query: 1201 ANDTDFIGNGN-GLILYSL 1218
A D D +GN LI YSL
Sbjct: 254 ATDAD---SGNFALIEYSL 269
Score = 40.7 bits (91), Expect = 0.039
Identities = 40/151 (26%), Positives = 67/151 (44%), Gaps = 12/151 (7%)
Query: 79 AYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS----LTIPLTV 134
A S+ + D+ VP P V ++++ + +F+ P G LT+P
Sbjct: 513 AVYSLILVASDLGQPVPYETMQPLQVALEDID---DNEPLFVRPPKGSPQYQLLTVPEHS 569
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
PRG + A D D+ PN+ V+Y I +GN++ +F L+ LL+ + LD + +
Sbjct: 570 PRGTLVGNVTGAVDADEG--PNAIVYYFIAAGNEEKNFHLQPD--GCLLVLRDLDRER-E 624
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAIDQDL 225
F ++ AS R P P + DL
Sbjct: 625 AIFSFIVKASSNRSWTPPRGPSPTLDLVADL 655
Score = 37.5 bits (83), Expect = 0.37
Identities = 19/51 (37%), Positives = 27/51 (52%), Gaps = 4/51 (7%)
Query: 1441 ATDSDIGINADIRYQILNEQAPR----FAIDPVSGTVRVVAALARDAGRVF 1487
ATD D G+N +RY L R F IDP+SG ++ L R++ V+
Sbjct: 465 ATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY 515
Score = 35.1 bits (77), Expect = 2.0
Identities = 21/54 (38%), Positives = 27/54 (50%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI 1084
VRV ++D+ND P F K Y V L +V A DAD G N+ + Y I
Sbjct: 660 VRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSI 713
>BC036062-1|AAH36062.1| 776|Homo sapiens protocadherin beta 16
protein.
Length = 776
Score = 103 bits (248), Expect = 4e-21
Identities = 127/496 (25%), Positives = 208/496 (41%), Gaps = 69/496 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P+GT +ALDLD G N Y+ + P S E F ++
Sbjct: 142 IPENSPLGTEFPLNHALDLDVGSNNVQNYKIS-----PSSHFRVLIHE----FRDGRKYP 192
Query: 1000 HVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+++ + L E E RL ++ALDGG+ + VR+ V D+ND+ P F++ Y +
Sbjct: 193 ELVLDKELDREEEPQLRLTLTALDGGSPPRSGTAQVRIEVVDINDNAPEFEQPIYKVQIP 252
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTY-FIQPS-DTDLPFEISPLTGVLSVNGELDRETE 1113
E ++ V A D D G N ++Y QPS D E++P+TG + + ++D E
Sbjct: 253 ENSPLGSLVATVSARDLDGGANGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFEMV 312
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK--FYAFDELLEWKHPE------- 1164
Y + + A D G DVNDN P+ A + PE
Sbjct: 313 TSYEVRIKATDGG---GLSGKCTLLLQVVDVNDNPPQVTMSALTSPIAENSPEIVVAVFS 369
Query: 1165 -ADELSNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQR 1221
+D S +N +++ ++I+E+ P + +V + T+ + Y++
Sbjct: 370 VSDPDSGNNGKTI-------SSIQEDLPFLLKPSVKNFYTLVTERALDREARAEYNI--T 420
Query: 1222 KNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL 1281
++G P L + + V ++DV D + P F Y L + EN + + + S++
Sbjct: 421 LTVTDMGTPRLKTEHNITVQISDVND-----NAPTFTQTSYTLFVRENNSPALHIGSVSA 475
Query: 1282 TEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREVKDTYEVIVRAER 1337
T+ N ++ Y +L D + + I+ NG L+ +RS D E +E V A
Sbjct: 476 TDRDSGTNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGAT- 534
Query: 1338 QKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTNGNRPLVTAIPT 1393
R P + + V V + D NDNSP NG+ P +P
Sbjct: 535 ---DRGSPAL-------------SREALVRVLVLDANDNSPLVLYPLQNGSAPCTELVPR 578
Query: 1394 TAPFGYQVMQLKGAIG 1409
A GY V ++ G
Sbjct: 579 AAEPGYLVTKVVAVDG 594
Score = 90.2 bits (214), Expect = 5e-17
Identities = 116/472 (24%), Positives = 194/472 (41%), Gaps = 40/472 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E + E+ ++D ND++P+F + + N+ +GT A+D D+G N +
Sbjct: 111 ENPLEIFQAELRVIDINDHSPMFTEKEMI-LKIPENSPLGTEFPLNHALDLDVGSNNVQN 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLA 553
Y + +S+ + + V + + E + L + A D + P R A
Sbjct: 170 YKISPSSHFRVLIHEFRDGRKYPELVLDKELDREEEPQLRLTLTALDGGSPP---RSGTA 226
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLL 611
V IEV + P+F Y+ + N +G+ V + D +SY L
Sbjct: 227 QVRIEVV----DINDNAPEFEQPIYKVQIPENSPLGSLVATVSARDLDGGANGKISYTLF 282
Query: 612 HGYEE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
E+ V +G + + + Y+ A + LS + VVDVN
Sbjct: 283 QPSEDISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIKAT-DGGGLSGKCTLLLQVVDVN 341
Query: 671 DERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D V + SPI ENS + ++ S GN N + + + Q+D+
Sbjct: 342 DNPPQVTMSALTSPIA----ENSPEIVVAVFSVSDPDS--GN---NGKTISSIQEDLPFL 392
Query: 730 I--AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVF 787
+ ++ T+ T++ LDRE R Y +T+ + G + +T+ I D NDN P F
Sbjct: 393 LKPSVKNFYTLVTERALDREARAEYNITLTVT-DMGTPRLKTEHNITVQISDVNDNAPTF 451
Query: 788 EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDE 841
+Y F+ EN+ I + ATD D GTNA Y+L + ++
Sbjct: 452 TQTSYTLFVRENNSPALHI---GSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINA 508
Query: 842 NTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
+ G + F SLD E ++ + A D G LS EA + +++ D NDN P
Sbjct: 509 DNGHL-FALRSLDYEALQAFEFRVGATDRGSPALSREALVRVLVLDANDNSP 559
Score = 89.8 bits (213), Expect = 6e-17
Identities = 73/242 (30%), Positives = 116/242 (47%), Gaps = 19/242 (7%)
Query: 659 VTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR- 717
+ A + V+D+ND + + +I + ENS +G F N + G+ NV+
Sbjct: 116 IFQAELRVIDINDHSPMFTE---KEMILKIPENSP---LGTEFPLNHALDLDVGSNNVQN 169
Query: 718 FLIANQQDVTDDIAIAEDGTIFTQ----KPLDREKRDVYRMTVIAEFNKGVISGAGIYQV 773
+ I+ I DG + + K LDRE+ R+T+ A + G +G QV
Sbjct: 170 YKISPSSHFRVLIHEFRDGRKYPELVLDKELDREEEPQLRLTLTA-LDGGSPPRSGTAQV 228
Query: 774 TIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG 833
I + D NDN P FE Y+ I ENS +G+ + + A D D G N YTLF
Sbjct: 229 RIEVVDINDNAPEFEQPIYKVQIPENSPLGSLVAT---VSARDLDGGANGKISYTLFQPS 285
Query: 834 KEM---FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNK 890
+++ +V+ TG V+ + +D E Y++ + A D GGLS + L++ + D NDN
Sbjct: 286 EDISKTLEVNPMTGEVR-LRKQVDFEMVTSYEVRIKATDGGGLSGKCTLLLQVVDVNDNP 344
Query: 891 PE 892
P+
Sbjct: 345 PQ 346
Score = 81.8 bits (193), Expect = 2e-14
Identities = 54/170 (31%), Positives = 85/170 (50%), Gaps = 13/170 (7%)
Query: 219 HAIDQDLGVGATLRYELISGNDRKLFSLDSVNG----SLFLEKELDLDAEHNLQANTFVL 274
HA+D D+G Y++ + ++ + +G L L+KELD + E L+ L
Sbjct: 156 HALDLDVGSNNVQNYKISPSSHFRVLIHEFRDGRKYPELVLDKELDREEEPQLR-----L 210
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A +P ++ A+V IE++D+NDN PEFE Y + I EN P G V V A D D
Sbjct: 211 TLTALDGGSPPRSGTAQVRIEVVDINDNAPEFEQPIYKVQIPENSPLGSLVATVSARDLD 270
Query: 335 QGENGEFTYQLDDPKGAFS----IDPRSGWLTVRNQTVLDREAHSSLRMK 380
G NG+ +Y L P S ++P +G + +R Q + +R+K
Sbjct: 271 GGANGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIK 320
Score = 76.2 bits (179), Expect = 9e-13
Identities = 74/246 (30%), Positives = 105/246 (42%), Gaps = 22/246 (8%)
Query: 911 NGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEF 970
+GTA I EV N A + +Q IPEN P+G+ + ++A DLD G NG+I Y
Sbjct: 223 SGTAQVRI-EVVDINDNAPEFEQPIYKVQIPENSPLGSLVATVSARDLDGGANGKISY-- 279
Query: 971 NSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDN 1028
PS+ + LEV N G V + + + E + + + I A DGG L+
Sbjct: 280 ---TLFQPSEDISKTLEV------NPMTGEVRLRKQVDFEMVTSYEVRIKATDGGGLSGK 330
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
++ + V DVND+ P + + E V+ +D D G N IQ
Sbjct: 331 CTLLLQVVDVNDNPPQVTMSALTSPIAE-NSPEIVVAVFSVSDPDSGNNGKTISSIQ--- 386
Query: 1089 TDLPFEISPLTG---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
DLPF + P L LDRE +Y +T+ D G DVN
Sbjct: 387 EDLPFLLKPSVKNFYTLVTERALDREARAEYNITLTVTDMG-TPRLKTEHNITVQISDVN 445
Query: 1146 DNSPKF 1151
DN+P F
Sbjct: 446 DNAPTF 451
Score = 64.1 bits (149), Expect = 4e-09
Identities = 80/299 (26%), Positives = 114/299 (38%), Gaps = 22/299 (7%)
Query: 858 KIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAG-- 915
KI Y L + D +S E+ M G+ K ++ + +VRI + T G +G
Sbjct: 276 KISYTLFQPSED---ISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRI-KATDGGGLSGKC 331
Query: 916 FTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVY 975
+++V N V I EN P + + D DSG NG+ ++
Sbjct: 332 TLLLQVVDVNDNPPQVTMSALTSPIAENSP-EIVVAVFSVSDPDSGNNGKTISSIQEDL- 389
Query: 976 IPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVFV 1035
P L Y ++ ER + R E L ++ + L ++ V +
Sbjct: 390 --PFLLKPSVKNF--YTLVTER----ALDREARAEYNITLTVTDMGTPRLKTEHNITVQI 441
Query: 1036 KDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSDTDLPF- 1093
DVND+ P F +T Y V E +G V ATD D G NA +TY + P D LP
Sbjct: 442 SDVNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLA 501
Query: 1094 ---EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
I+ G L LD E + V A D G D NDNSP
Sbjct: 502 SLVSINADNGHLFALRSLDYEALQAFEFRVGATDRG-SPALSREALVRVLVLDANDNSP 559
Score = 61.7 bits (143), Expect = 2e-08
Identities = 56/181 (30%), Positives = 84/181 (46%), Gaps = 20/181 (11%)
Query: 218 IHAIDQDLGVGATLRYELISGND-----RKLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A D+D G A + Y L+ D L S+++ NG LF + LD +A LQA F
Sbjct: 473 VSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEA---LQA--F 527
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISI--VENLPN----GFSVL 326
+V A+ +P + +A V + +LD NDN P N S E +P G+ V
Sbjct: 528 EFRVGATDRGSPALSREALVRVLVLDANDNSPLVLYPLQNGSAPCTELVPRAAEPGYLVT 587
Query: 327 QVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAK 384
+V+A D D G+N +YQL G F + +G VR +L + R+ V K
Sbjct: 588 KVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG--EVRTARLLSERDAAKQRLVVLVK 645
Query: 385 E 385
+
Sbjct: 646 D 646
Score = 60.1 bits (139), Expect = 6e-08
Identities = 50/169 (29%), Positives = 78/169 (46%), Gaps = 9/169 (5%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
A+ G + + LDRE+ I F + + I+Q + + D ND+ P+F
Sbjct: 79 AQTGDLLINEKLDREELCGPTEPCILHFQVLMENPLEIFQAELRVIDINDHSPMFTEKEM 138
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF---- 848
I ENS +GTE +++ A D D G+N + Y + + E K+
Sbjct: 139 ILKIPENSPLGTEFPLNH---ALDLDVGSNNVQNYKISPSSHFRVLIHEFRDGRKYPELV 195
Query: 849 IGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+ LDRE++ +L+L A D G S A++ I + D NDN PEF Q
Sbjct: 196 LDKELDREEEPQLRLTLTALDGGSPPRSGTAQVRIEVVDINDNAPEFEQ 244
Score = 58.8 bits (136), Expect = 1e-07
Identities = 60/218 (27%), Positives = 88/218 (40%), Gaps = 18/218 (8%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+++ N A Q + EN I ++A D DSG N Q+ Y +PP
Sbjct: 439 VQISDVNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSL-----LPP 493
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVF 1034
L + IN +GH+ RSL E+ F + A D G+ L+ VRV
Sbjct: 494 QD---PHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPALSREALVRVL 550
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQPSD 1088
V D ND+ P+ N + + R ++ KV A D D GQNA L+Y + +
Sbjct: 551 VLDANDNSPLVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKAT 610
Query: 1089 TDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
F + G + L K L V+ +DNG
Sbjct: 611 EPGLFGVWAHNGEVRTARLLSERDAAKQRLVVLVKDNG 648
Score = 58.0 bits (134), Expect = 2e-07
Identities = 86/364 (23%), Positives = 141/364 (38%), Gaps = 51/364 (14%)
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD----TD 1090
V D+NDH P+F + + E A D D G N Y I PS
Sbjct: 123 VIDINDHSPMFTEKEMILKIPENSPLGTEFPLNHALDLDVGSNNVQNYKISPSSHFRVLI 182
Query: 1091 LPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
F L ++ ELDRE E + LT+ A D G D+NDN+P+
Sbjct: 183 HEFRDGRKYPELVLDKELDREEEPQLRLTLTALDGG-SPPRSGTAQVRIEVVDINDNAPE 241
Query: 1151 FYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNG 1210
F + P +YK I EN+P+G+ VA V A D D G
Sbjct: 242 F---------EQP-----------------IYKVQIPENSPLGSLVATVSARDLD--GGA 273
Query: 1211 NGLILYSL--PQRKNQQNLGLPSLSSTAIL-------MVTVADV----PDEVEMSDKPVF 1257
NG I Y+L P + L + ++ L MVT +V D +S K
Sbjct: 274 NGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIKATDGGGLSGKCTL 333
Query: 1258 ISRYYELEIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYL 1317
+ + ++ + + ++ + E+ + + +++ D+ + + +L
Sbjct: 334 LLQVVDVN-DNPPQVTMSALTSPIAENSPEIVVAVFSVSDPDSGNNGKTISSIQEDLPFL 392
Query: 1318 VRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNS 1377
++ VK+ Y ++ + +R + I D+ K + + V+I DVNDN+
Sbjct: 393 LKP---SVKNFYTLVTERALDREAR-AEYNITLTVTDMGTPRLKTEHNITVQISDVNDNA 448
Query: 1378 PKFT 1381
P FT
Sbjct: 449 PTFT 452
Score = 54.8 bits (126), Expect = 2e-06
Identities = 71/291 (24%), Positives = 112/291 (38%), Gaps = 16/291 (5%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPI-- 124
L + G S V + + D+NDN P F Y V + E +P G +
Sbjct: 212 LTALDGGSPPRSGTAQVRIEVVDINDNAPEFEQPIYKVQIPENSPLGSLVATVSARDLDG 271
Query: 125 GPSLTIPLTVPR-GLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALES---SHKP 180
G + I T+ + I K + V + +V+ + A + S K
Sbjct: 272 GANGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIKATDGGGLSGKC 331
Query: 181 VLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND 240
LLL+ V D D Q+ + A I + PE + A+ + + IS
Sbjct: 332 TLLLQVV---DVNDNPPQVTMSALTSPIAENS--PEIVVAVFSVSDPDSGNNGKTISSIQ 386
Query: 241 RKL-FSLD-SVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
L F L SV L E LD E + N + + + + P + + +++ D
Sbjct: 387 EDLPFLLKPSVKNFYTLVTERALDREARAEYN---ITLTVTDMGTPRLKTEHNITVQISD 443
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
+NDN P F Y + + EN + V ATD+D G N + TY L P+
Sbjct: 444 VNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQ 494
Score = 48.0 bits (109), Expect = 3e-04
Identities = 48/172 (27%), Positives = 79/172 (45%), Gaps = 14/172 (8%)
Query: 221 IDQDLGVG----ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ +DLG+G +T + +IS +++ L + G L + ++LD + E +L
Sbjct: 48 LGKDLGLGLTEMSTRKARIISQGNKQHLQLKAQTGDLLINEKLDRE-ELCGPTEPCILHF 106
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
Q + NPL+ QA E+ ++D+ND+ P F + I EN P G A D D G
Sbjct: 107 QVL-MENPLEIFQA--ELRVIDINDHSPMFTEKEMILKIPENSPLGTEFPLNHALDLDVG 163
Query: 337 ENGEFTYQLDDPKGAFSI---DPRSG--WLTVRNQTVLDREAHSSLRMKVYA 383
N Y++ P F + + R G + + LDRE LR+ + A
Sbjct: 164 SNNVQNYKI-SPSSHFRVLIHEFRDGRKYPELVLDKELDREEEPQLRLTLTA 214
Score = 42.7 bits (96), Expect = 0.010
Identities = 35/161 (21%), Positives = 72/161 (44%), Gaps = 12/161 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGND--RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A D D G + Y L ++ K ++ + G + L K++D + ++ ++
Sbjct: 264 VSARDLDGGANGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFE-----MVTSYEVR 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
++A+ + + + ++++D+NDN P+ + I EN P V +D D
Sbjct: 319 IKATDGGG--LSGKCTLLLQVVDVNDNPPQVTMSALTSPIAENSPE-IVVAVFSVSDPDS 375
Query: 336 GENGEFTYQLDDPKGAFSIDPR-SGWLTVRNQTVLDREAHS 375
G NG+ + + F + P + T+ + LDREA +
Sbjct: 376 GNNGKTISSIQEDL-PFLLKPSVKNFYTLVTERALDREARA 415
Score = 36.3 bits (80), Expect = 0.85
Identities = 34/120 (28%), Positives = 56/120 (46%), Gaps = 8/120 (6%)
Query: 445 VEVTLLDANDNNP-VFVP----SNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
V V +LDANDN+P V P S + A+ G ++ KV AVD D GQN + Y L
Sbjct: 547 VRVLVLDANDNSPLVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQL 606
Query: 500 QRTSNLTITSPFKINPNTGTVS-VAESPILEGRHALFVEASDQPANPSERRYSLAVVTIE 558
+ + + + N T ++E + R + V+ + +P P +L V+ ++
Sbjct: 607 LKATEPGLFGVWAHNGEVRTARLLSERDAAKQRLVVLVKDNGEP--PRSATATLHVLLVD 664
>AF282973-2|AAG10030.1| 776|Homo sapiens protocadherin-3x protein.
Length = 776
Score = 103 bits (248), Expect = 4e-21
Identities = 127/496 (25%), Positives = 208/496 (41%), Gaps = 69/496 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P+GT +ALDLD G N Y+ + P S E F ++
Sbjct: 142 IPENSPLGTEFPLNHALDLDVGSNNVQNYKIS-----PSSHFRVLIHE----FRDGRKYP 192
Query: 1000 HVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+++ + L E E RL ++ALDGG+ + VR+ V D+ND+ P F++ Y +
Sbjct: 193 ELVLDKELDREEEPQLRLTLTALDGGSPPRSGTAQVRIEVVDINDNAPEFEQPIYKVQIP 252
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTY-FIQPS-DTDLPFEISPLTGVLSVNGELDRETE 1113
E ++ V A D D G N ++Y QPS D E++P+TG + + ++D E
Sbjct: 253 ENSPLGSLVATVSARDLDGGANGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFEMV 312
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK--FYAFDELLEWKHPE------- 1164
Y + + A D G DVNDN P+ A + PE
Sbjct: 313 TSYEVRIKATDGG---GLSGKCTLLLQVVDVNDNPPQVTMSALTSPIPENSPEIVVAVFS 369
Query: 1165 -ADELSNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQR 1221
+D S +N +++ ++I+E+ P + +V + T+ + Y++
Sbjct: 370 VSDPDSGNNGKTI-------SSIQEDLPFLLKPSVKNFYTLVTERALDREARAEYNI--T 420
Query: 1222 KNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL 1281
++G P L + + V ++DV D + P F Y L + EN + + + S++
Sbjct: 421 LTVTDMGTPRLKTEHNITVQISDVND-----NAPTFTQTSYTLFVRENNSPALHIGSVSA 475
Query: 1282 TEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREVKDTYEVIVRAER 1337
T+ N ++ Y +L D + + I+ NG L+ +RS D E +E V A
Sbjct: 476 TDRDSGTNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGAT- 534
Query: 1338 QKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTNGNRPLVTAIPT 1393
R P + + V V + D NDNSP NG+ P +P
Sbjct: 535 ---DRGSPAL-------------SREALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPR 578
Query: 1394 TAPFGYQVMQLKGAIG 1409
A GY V ++ G
Sbjct: 579 AAEPGYLVTKVVAVDG 594
Score = 90.2 bits (214), Expect = 5e-17
Identities = 116/472 (24%), Positives = 194/472 (41%), Gaps = 40/472 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E + E+ ++D ND++P+F + + N+ +GT A+D D+G N +
Sbjct: 111 ENPLEIFQAELRVIDINDHSPMFTEKEMI-LKIPENSPLGTEFPLNHALDLDVGSNNVQN 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLA 553
Y + +S+ + + V + + E + L + A D + P R A
Sbjct: 170 YKISPSSHFRVLIHEFRDGRKYPELVLDKELDREEEPQLRLTLTALDGGSPP---RSGTA 226
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLL 611
V IEV + P+F Y+ + N +G+ V + D +SY L
Sbjct: 227 QVRIEVV----DINDNAPEFEQPIYKVQIPENSPLGSLVATVSARDLDGGANGKISYTLF 282
Query: 612 HGYEE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
E+ V +G + + + Y+ A + LS + VVDVN
Sbjct: 283 QPSEDISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIKAT-DGGGLSGKCTLLLQVVDVN 341
Query: 671 DERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D V + SPI ENS + ++ S GN N + + + Q+D+
Sbjct: 342 DNPPQVTMSALTSPI----PENSPEIVVAVFSVSDPDS--GN---NGKTISSIQEDLPFL 392
Query: 730 I--AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVF 787
+ ++ T+ T++ LDRE R Y +T+ + G + +T+ I D NDN P F
Sbjct: 393 LKPSVKNFYTLVTERALDREARAEYNITLTVT-DMGTPRLKTEHNITVQISDVNDNAPTF 451
Query: 788 EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDE 841
+Y F+ EN+ I + ATD D GTNA Y+L + ++
Sbjct: 452 TQTSYTLFVRENNSPALHI---GSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINA 508
Query: 842 NTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
+ G + F SLD E ++ + A D G LS EA + +++ D NDN P
Sbjct: 509 DNGHL-FALRSLDYEALQAFEFRVGATDRGSPALSREALVRVLVLDANDNSP 559
Score = 89.8 bits (213), Expect = 6e-17
Identities = 73/242 (30%), Positives = 116/242 (47%), Gaps = 19/242 (7%)
Query: 659 VTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR- 717
+ A + V+D+ND + + +I + ENS +G F N + G+ NV+
Sbjct: 116 IFQAELRVIDINDHSPMFTE---KEMILKIPENSP---LGTEFPLNHALDLDVGSNNVQN 169
Query: 718 FLIANQQDVTDDIAIAEDGTIFTQ----KPLDREKRDVYRMTVIAEFNKGVISGAGIYQV 773
+ I+ I DG + + K LDRE+ R+T+ A + G +G QV
Sbjct: 170 YKISPSSHFRVLIHEFRDGRKYPELVLDKELDREEEPQLRLTLTA-LDGGSPPRSGTAQV 228
Query: 774 TIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG 833
I + D NDN P FE Y+ I ENS +G+ + + A D D G N YTLF
Sbjct: 229 RIEVVDINDNAPEFEQPIYKVQIPENSPLGSLVAT---VSARDLDGGANGKISYTLFQPS 285
Query: 834 KEM---FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNK 890
+++ +V+ TG V+ + +D E Y++ + A D GGLS + L++ + D NDN
Sbjct: 286 EDISKTLEVNPMTGEVR-LRKQVDFEMVTSYEVRIKATDGGGLSGKCTLLLQVVDVNDNP 344
Query: 891 PE 892
P+
Sbjct: 345 PQ 346
Score = 81.8 bits (193), Expect = 2e-14
Identities = 54/170 (31%), Positives = 85/170 (50%), Gaps = 13/170 (7%)
Query: 219 HAIDQDLGVGATLRYELISGNDRKLFSLDSVNG----SLFLEKELDLDAEHNLQANTFVL 274
HA+D D+G Y++ + ++ + +G L L+KELD + E L+ L
Sbjct: 156 HALDLDVGSNNVQNYKISPSSHFRVLIHEFRDGRKYPELVLDKELDREEEPQLR-----L 210
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A +P ++ A+V IE++D+NDN PEFE Y + I EN P G V V A D D
Sbjct: 211 TLTALDGGSPPRSGTAQVRIEVVDINDNAPEFEQPIYKVQIPENSPLGSLVATVSARDLD 270
Query: 335 QGENGEFTYQLDDPKGAFS----IDPRSGWLTVRNQTVLDREAHSSLRMK 380
G NG+ +Y L P S ++P +G + +R Q + +R+K
Sbjct: 271 GGANGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIK 320
Score = 76.2 bits (179), Expect = 9e-13
Identities = 74/246 (30%), Positives = 105/246 (42%), Gaps = 22/246 (8%)
Query: 911 NGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEF 970
+GTA I EV N A + +Q IPEN P+G+ + ++A DLD G NG+I Y
Sbjct: 223 SGTAQVRI-EVVDINDNAPEFEQPIYKVQIPENSPLGSLVATVSARDLDGGANGKISY-- 279
Query: 971 NSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDN 1028
PS+ + LEV N G V + + + E + + + I A DGG L+
Sbjct: 280 ---TLFQPSEDISKTLEV------NPMTGEVRLRKQVDFEMVTSYEVRIKATDGGGLSGK 330
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
++ + V DVND+ P + + E V+ +D D G N IQ
Sbjct: 331 CTLLLQVVDVNDNPPQVTMSALTSPIPE-NSPEIVVAVFSVSDPDSGNNGKTISSIQ--- 386
Query: 1089 TDLPFEISPLTG---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
DLPF + P L LDRE +Y +T+ D G DVN
Sbjct: 387 EDLPFLLKPSVKNFYTLVTERALDREARAEYNITLTVTDMG-TPRLKTEHNITVQISDVN 445
Query: 1146 DNSPKF 1151
DN+P F
Sbjct: 446 DNAPTF 451
Score = 67.3 bits (157), Expect = 4e-10
Identities = 81/299 (27%), Positives = 115/299 (38%), Gaps = 22/299 (7%)
Query: 858 KIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAG-- 915
KI Y L + D +S E+ M G+ K ++ + +VRI + T G +G
Sbjct: 276 KISYTLFQPSED---ISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRI-KATDGGGLSGKC 331
Query: 916 FTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVY 975
+++V N V IPEN P + + D DSG NG+ ++
Sbjct: 332 TLLLQVVDVNDNPPQVTMSALTSPIPENSP-EIVVAVFSVSDPDSGNNGKTISSIQEDL- 389
Query: 976 IPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVFV 1035
P L Y ++ ER + R E L ++ + L ++ V +
Sbjct: 390 --PFLLKPSVKNF--YTLVTER----ALDREARAEYNITLTVTDMGTPRLKTEHNITVQI 441
Query: 1036 KDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSDTDLPF- 1093
DVND+ P F +T Y V E +G V ATD D G NA +TY + P D LP
Sbjct: 442 SDVNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLA 501
Query: 1094 ---EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
I+ G L LD E + V A D G D NDNSP
Sbjct: 502 SLVSINADNGHLFALRSLDYEALQAFEFRVGATDRG-SPALSREALVRVLVLDANDNSP 559
Score = 61.7 bits (143), Expect = 2e-08
Identities = 56/181 (30%), Positives = 84/181 (46%), Gaps = 20/181 (11%)
Query: 218 IHAIDQDLGVGATLRYELISGND-----RKLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A D+D G A + Y L+ D L S+++ NG LF + LD +A LQA F
Sbjct: 473 VSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEA---LQA--F 527
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISI--VENLPN----GFSVL 326
+V A+ +P + +A V + +LD NDN P N S E +P G+ V
Sbjct: 528 EFRVGATDRGSPALSREALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVT 587
Query: 327 QVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAK 384
+V+A D D G+N +YQL G F + +G VR +L + R+ V K
Sbjct: 588 KVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG--EVRTARLLSERDAAKQRLVVLVK 645
Query: 385 E 385
+
Sbjct: 646 D 646
Score = 60.1 bits (139), Expect = 6e-08
Identities = 50/169 (29%), Positives = 78/169 (46%), Gaps = 9/169 (5%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
A+ G + + LDRE+ I F + + I+Q + + D ND+ P+F
Sbjct: 79 AQTGDLLINEKLDREELCGPTEPCILHFQVLMENPLEIFQAELRVIDINDHSPMFTEKEM 138
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF---- 848
I ENS +GTE +++ A D D G+N + Y + + E K+
Sbjct: 139 ILKIPENSPLGTEFPLNH---ALDLDVGSNNVQNYKISPSSHFRVLIHEFRDGRKYPELV 195
Query: 849 IGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+ LDRE++ +L+L A D G S A++ I + D NDN PEF Q
Sbjct: 196 LDKELDREEEPQLRLTLTALDGGSPPRSGTAQVRIEVVDINDNAPEFEQ 244
Score = 58.0 bits (134), Expect = 2e-07
Identities = 60/218 (27%), Positives = 87/218 (39%), Gaps = 18/218 (8%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+++ N A Q + EN I ++A D DSG N Q+ Y +PP
Sbjct: 439 VQISDVNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSL-----LPP 493
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVF 1034
L + IN +GH+ RSL E+ F + A D G+ L+ VRV
Sbjct: 494 QD---PHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPALSREALVRVL 550
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQPSD 1088
V D ND+ P N + + R ++ KV A D D GQNA L+Y + +
Sbjct: 551 VLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKAT 610
Query: 1089 TDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
F + G + L K L V+ +DNG
Sbjct: 611 EPGLFGVWAHNGEVRTARLLSERDAAKQRLVVLVKDNG 648
Score = 57.6 bits (133), Expect = 3e-07
Identities = 86/364 (23%), Positives = 141/364 (38%), Gaps = 51/364 (14%)
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD----TD 1090
V D+NDH P+F + + E A D D G N Y I PS
Sbjct: 123 VIDINDHSPMFTEKEMILKIPENSPLGTEFPLNHALDLDVGSNNVQNYKISPSSHFRVLI 182
Query: 1091 LPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
F L ++ ELDRE E + LT+ A D G D+NDN+P+
Sbjct: 183 HEFRDGRKYPELVLDKELDREEEPQLRLTLTALDGG-SPPRSGTAQVRIEVVDINDNAPE 241
Query: 1151 FYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNG 1210
F + P +YK I EN+P+G+ VA V A D D G
Sbjct: 242 F---------EQP-----------------IYKVQIPENSPLGSLVATVSARDLD--GGA 273
Query: 1211 NGLILYSL--PQRKNQQNLGLPSLSSTAIL-------MVTVADV----PDEVEMSDKPVF 1257
NG I Y+L P + L + ++ L MVT +V D +S K
Sbjct: 274 NGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIKATDGGGLSGKCTL 333
Query: 1258 ISRYYELEIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYL 1317
+ + ++ + + ++ + E+ + + +++ D+ + + +L
Sbjct: 334 LLQVVDVN-DNPPQVTMSALTSPIPENSPEIVVAVFSVSDPDSGNNGKTISSIQEDLPFL 392
Query: 1318 VRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNS 1377
++ VK+ Y ++ + +R + I D+ K + + V+I DVNDN+
Sbjct: 393 LKP---SVKNFYTLVTERALDREAR-AEYNITLTVTDMGTPRLKTEHNITVQISDVNDNA 448
Query: 1378 PKFT 1381
P FT
Sbjct: 449 PTFT 452
Score = 54.8 bits (126), Expect = 2e-06
Identities = 71/291 (24%), Positives = 112/291 (38%), Gaps = 16/291 (5%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPI-- 124
L + G S V + + D+NDN P F Y V + E +P G +
Sbjct: 212 LTALDGGSPPRSGTAQVRIEVVDINDNAPEFEQPIYKVQIPENSPLGSLVATVSARDLDG 271
Query: 125 GPSLTIPLTVPR-GLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALES---SHKP 180
G + I T+ + I K + V + +V+ + A + S K
Sbjct: 272 GANGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIKATDGGGLSGKC 331
Query: 181 VLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND 240
LLL+ V D D Q+ + A I + PE + A+ + + IS
Sbjct: 332 TLLLQVV---DVNDNPPQVTMSALTSPIPENS--PEIVVAVFSVSDPDSGNNGKTISSIQ 386
Query: 241 RKL-FSLD-SVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
L F L SV L E LD E + N + + + + P + + +++ D
Sbjct: 387 EDLPFLLKPSVKNFYTLVTERALDREARAEYN---ITLTVTDMGTPRLKTEHNITVQISD 443
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
+NDN P F Y + + EN + V ATD+D G N + TY L P+
Sbjct: 444 VNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQ 494
Score = 48.0 bits (109), Expect = 3e-04
Identities = 48/172 (27%), Positives = 79/172 (45%), Gaps = 14/172 (8%)
Query: 221 IDQDLGVG----ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ +DLG+G +T + +IS +++ L + G L + ++LD + E +L
Sbjct: 48 LGKDLGLGLTEMSTRKARIISQGNKQHLQLKAQTGDLLINEKLDRE-ELCGPTEPCILHF 106
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
Q + NPL+ QA E+ ++D+ND+ P F + I EN P G A D D G
Sbjct: 107 QVL-MENPLEIFQA--ELRVIDINDHSPMFTEKEMILKIPENSPLGTEFPLNHALDLDVG 163
Query: 337 ENGEFTYQLDDPKGAFSI---DPRSG--WLTVRNQTVLDREAHSSLRMKVYA 383
N Y++ P F + + R G + + LDRE LR+ + A
Sbjct: 164 SNNVQNYKI-SPSSHFRVLIHEFRDGRKYPELVLDKELDREEEPQLRLTLTA 214
Score = 47.6 bits (108), Expect = 3e-04
Identities = 62/235 (26%), Positives = 94/235 (40%), Gaps = 14/235 (5%)
Query: 444 NVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL--QR 501
N+ V + D NDN P F ++ Y ++ N IG V A D D G N V Y L +
Sbjct: 436 NITVQISDVNDNAPTFTQTS-YTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQ 494
Query: 502 TSNLTITSPFKINPNTGTVSVAESPILEGRHAL-FVEASDQPANPSERRYSLAVVTIEVT 560
+L + S IN + G + S E A F + +P+ R +L V +
Sbjct: 495 DPHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPALSREALVRVLV--- 551
Query: 561 RGTKGNKPDI--PDFMG-APYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYE 615
N P + P G AP V G V ++ D+ + +SY LL E
Sbjct: 552 LDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATE 611
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
G+ F V +G + LS + V +++N AT+HV+ V+
Sbjct: 612 PGL-FGVWAHNGEVRTARLLSERDAAKQRL-VVLVKDNGEPPRSATATLHVLLVD 664
Score = 41.9 bits (94), Expect = 0.017
Identities = 35/161 (21%), Positives = 72/161 (44%), Gaps = 12/161 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGND--RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A D D G + Y L ++ K ++ + G + L K++D + ++ ++
Sbjct: 264 VSARDLDGGANGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFE-----MVTSYEVR 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
++A+ + + + ++++D+NDN P+ + I EN P V +D D
Sbjct: 319 IKATDGGG--LSGKCTLLLQVVDVNDNPPQVTMSALTSPIPENSPE-IVVAVFSVSDPDS 375
Query: 336 GENGEFTYQLDDPKGAFSIDPR-SGWLTVRNQTVLDREAHS 375
G NG+ + + F + P + T+ + LDREA +
Sbjct: 376 GNNGKTISSIQEDL-PFLLKPSVKNFYTLVTERALDREARA 415
>AF217757-1|AAF81914.1| 776|Homo sapiens protocadherin 3X protein.
Length = 776
Score = 103 bits (248), Expect = 4e-21
Identities = 127/496 (25%), Positives = 208/496 (41%), Gaps = 69/496 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P+GT +ALDLD G N Y+ + P S E F ++
Sbjct: 142 IPENSPLGTEFPLNHALDLDVGSNNVQNYKIS-----PSSHFRVLIHE----FRDGRKYP 192
Query: 1000 HVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+++ + L E E RL ++ALDGG+ + VR+ V D+ND+ P F++ Y +
Sbjct: 193 ELVLDKELDREEEPQLRLTLTALDGGSPPRSGTAQVRIEVVDINDNAPEFEQPIYKVQIP 252
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTY-FIQPS-DTDLPFEISPLTGVLSVNGELDRETE 1113
E ++ V A D D G N ++Y QPS D E++P+TG + + ++D E
Sbjct: 253 ENSPLGSLVATVSARDLDGGANGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFEMV 312
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK--FYAFDELLEWKHPE------- 1164
Y + + A D G DVNDN P+ A + PE
Sbjct: 313 TSYEVRIKATDGG---GLSGKCTLLLQVVDVNDNPPQVTMSALTSPIPENSPEIVVAVFS 369
Query: 1165 -ADELSNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQR 1221
+D S +N +++ ++I+E+ P + +V + T+ + Y++
Sbjct: 370 VSDPDSGNNGKTI-------SSIQEDLPFLLKPSVKNFYTLVTERALDREARAEYNI--T 420
Query: 1222 KNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL 1281
++G P L + + V ++DV D + P F Y L + EN + + + S++
Sbjct: 421 LTVTDMGTPRLKTEHNITVQISDVND-----NAPTFTQTSYTLFVRENNSPALHIGSVSA 475
Query: 1282 TEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREVKDTYEVIVRAER 1337
T+ N ++ Y +L D + + I+ NG L+ +RS D E +E V A
Sbjct: 476 TDRDSGTNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGAT- 534
Query: 1338 QKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTNGNRPLVTAIPT 1393
R P + + V V + D NDNSP NG+ P +P
Sbjct: 535 ---DRGSPAL-------------SREALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPR 578
Query: 1394 TAPFGYQVMQLKGAIG 1409
A GY V ++ G
Sbjct: 579 AAEPGYLVTKVVAVDG 594
Score = 90.2 bits (214), Expect = 5e-17
Identities = 116/472 (24%), Positives = 194/472 (41%), Gaps = 40/472 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E + E+ ++D ND++P+F + + N+ +GT A+D D+G N +
Sbjct: 111 ENPLEIFQAELRVIDINDHSPMFTEKEMI-LKIPENSPLGTEFPLNHALDLDVGSNNVQN 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLA 553
Y + +S+ + + V + + E + L + A D + P R A
Sbjct: 170 YKISPSSHFRVLIHEFRDGRKYPELVLDKELDREEEPQLRLTLTALDGGSPP---RSGTA 226
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLL 611
V IEV + P+F Y+ + N +G+ V + D +SY L
Sbjct: 227 QVRIEVV----DINDNAPEFEQPIYKVQIPENSPLGSLVATVSARDLDGGANGKISYTLF 282
Query: 612 HGYEE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
E+ V +G + + + Y+ A + LS + VVDVN
Sbjct: 283 QPSEDISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIKAT-DGGGLSGKCTLLLQVVDVN 341
Query: 671 DERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D V + SPI ENS + ++ S GN N + + + Q+D+
Sbjct: 342 DNPPQVTMSALTSPI----PENSPEIVVAVFSVSDPDS--GN---NGKTISSIQEDLPFL 392
Query: 730 I--AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVF 787
+ ++ T+ T++ LDRE R Y +T+ + G + +T+ I D NDN P F
Sbjct: 393 LKPSVKNFYTLVTERALDREARAEYNITLTVT-DMGTPRLKTEHNITVQISDVNDNAPTF 451
Query: 788 EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDE 841
+Y F+ EN+ I + ATD D GTNA Y+L + ++
Sbjct: 452 TQTSYTLFVRENNSPALHI---GSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINA 508
Query: 842 NTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
+ G + F SLD E ++ + A D G LS EA + +++ D NDN P
Sbjct: 509 DNGHL-FALRSLDYEALQAFEFRVGATDRGSPALSREALVRVLVLDANDNSP 559
Score = 89.8 bits (213), Expect = 6e-17
Identities = 73/242 (30%), Positives = 116/242 (47%), Gaps = 19/242 (7%)
Query: 659 VTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR- 717
+ A + V+D+ND + + +I + ENS +G F N + G+ NV+
Sbjct: 116 IFQAELRVIDINDHSPMFTE---KEMILKIPENSP---LGTEFPLNHALDLDVGSNNVQN 169
Query: 718 FLIANQQDVTDDIAIAEDGTIFTQ----KPLDREKRDVYRMTVIAEFNKGVISGAGIYQV 773
+ I+ I DG + + K LDRE+ R+T+ A + G +G QV
Sbjct: 170 YKISPSSHFRVLIHEFRDGRKYPELVLDKELDREEEPQLRLTLTA-LDGGSPPRSGTAQV 228
Query: 774 TIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG 833
I + D NDN P FE Y+ I ENS +G+ + + A D D G N YTLF
Sbjct: 229 RIEVVDINDNAPEFEQPIYKVQIPENSPLGSLVAT---VSARDLDGGANGKISYTLFQPS 285
Query: 834 KEM---FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNK 890
+++ +V+ TG V+ + +D E Y++ + A D GGLS + L++ + D NDN
Sbjct: 286 EDISKTLEVNPMTGEVR-LRKQVDFEMVTSYEVRIKATDGGGLSGKCTLLLQVVDVNDNP 344
Query: 891 PE 892
P+
Sbjct: 345 PQ 346
Score = 81.8 bits (193), Expect = 2e-14
Identities = 54/170 (31%), Positives = 85/170 (50%), Gaps = 13/170 (7%)
Query: 219 HAIDQDLGVGATLRYELISGNDRKLFSLDSVNG----SLFLEKELDLDAEHNLQANTFVL 274
HA+D D+G Y++ + ++ + +G L L+KELD + E L+ L
Sbjct: 156 HALDLDVGSNNVQNYKISPSSHFRVLIHEFRDGRKYPELVLDKELDREEEPQLR-----L 210
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A +P ++ A+V IE++D+NDN PEFE Y + I EN P G V V A D D
Sbjct: 211 TLTALDGGSPPRSGTAQVRIEVVDINDNAPEFEQPIYKVQIPENSPLGSLVATVSARDLD 270
Query: 335 QGENGEFTYQLDDPKGAFS----IDPRSGWLTVRNQTVLDREAHSSLRMK 380
G NG+ +Y L P S ++P +G + +R Q + +R+K
Sbjct: 271 GGANGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIK 320
Score = 76.2 bits (179), Expect = 9e-13
Identities = 74/246 (30%), Positives = 105/246 (42%), Gaps = 22/246 (8%)
Query: 911 NGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEF 970
+GTA I EV N A + +Q IPEN P+G+ + ++A DLD G NG+I Y
Sbjct: 223 SGTAQVRI-EVVDINDNAPEFEQPIYKVQIPENSPLGSLVATVSARDLDGGANGKISY-- 279
Query: 971 NSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDN 1028
PS+ + LEV N G V + + + E + + + I A DGG L+
Sbjct: 280 ---TLFQPSEDISKTLEV------NPMTGEVRLRKQVDFEMVTSYEVRIKATDGGGLSGK 330
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
++ + V DVND+ P + + E V+ +D D G N IQ
Sbjct: 331 CTLLLQVVDVNDNPPQVTMSALTSPIPE-NSPEIVVAVFSVSDPDSGNNGKTISSIQ--- 386
Query: 1089 TDLPFEISPLTG---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
DLPF + P L LDRE +Y +T+ D G DVN
Sbjct: 387 EDLPFLLKPSVKNFYTLVTERALDREARAEYNITLTVTDMG-TPRLKTEHNITVQISDVN 445
Query: 1146 DNSPKF 1151
DN+P F
Sbjct: 446 DNAPTF 451
Score = 67.3 bits (157), Expect = 4e-10
Identities = 81/299 (27%), Positives = 115/299 (38%), Gaps = 22/299 (7%)
Query: 858 KIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAG-- 915
KI Y L + D +S E+ M G+ K ++ + +VRI + T G +G
Sbjct: 276 KISYTLFQPSED---ISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRI-KATDGGGLSGKC 331
Query: 916 FTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVY 975
+++V N V IPEN P + + D DSG NG+ ++
Sbjct: 332 TLLLQVVDVNDNPPQVTMSALTSPIPENSP-EIVVAVFSVSDPDSGNNGKTISSIQEDL- 389
Query: 976 IPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVFV 1035
P L Y ++ ER + R E L ++ + L ++ V +
Sbjct: 390 --PFLLKPSVKNF--YTLVTER----ALDREARAEYNITLTVTDMGTPRLKTEHNITVQI 441
Query: 1036 KDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSDTDLPF- 1093
DVND+ P F +T Y V E +G V ATD D G NA +TY + P D LP
Sbjct: 442 SDVNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLA 501
Query: 1094 ---EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
I+ G L LD E + V A D G D NDNSP
Sbjct: 502 SLVSINADNGHLFALRSLDYEALQAFEFRVGATDRG-SPALSREALVRVLVLDANDNSP 559
Score = 61.7 bits (143), Expect = 2e-08
Identities = 56/181 (30%), Positives = 84/181 (46%), Gaps = 20/181 (11%)
Query: 218 IHAIDQDLGVGATLRYELISGND-----RKLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A D+D G A + Y L+ D L S+++ NG LF + LD +A LQA F
Sbjct: 473 VSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEA---LQA--F 527
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISI--VENLPN----GFSVL 326
+V A+ +P + +A V + +LD NDN P N S E +P G+ V
Sbjct: 528 EFRVGATDRGSPALSREALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVT 587
Query: 327 QVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAK 384
+V+A D D G+N +YQL G F + +G VR +L + R+ V K
Sbjct: 588 KVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG--EVRTARLLSERDAAKQRLVVLVK 645
Query: 385 E 385
+
Sbjct: 646 D 646
Score = 60.1 bits (139), Expect = 6e-08
Identities = 50/169 (29%), Positives = 78/169 (46%), Gaps = 9/169 (5%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
A+ G + + LDRE+ I F + + I+Q + + D ND+ P+F
Sbjct: 79 AQTGDLLINEKLDREELCGPTEPCILHFQVLMENPLEIFQAELRVIDINDHSPMFTEKEM 138
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF---- 848
I ENS +GTE +++ A D D G+N + Y + + E K+
Sbjct: 139 ILKIPENSPLGTEFPLNH---ALDLDVGSNNVQNYKISPSSHFRVLIHEFRDGRKYPELV 195
Query: 849 IGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+ LDRE++ +L+L A D G S A++ I + D NDN PEF Q
Sbjct: 196 LDKELDREEEPQLRLTLTALDGGSPPRSGTAQVRIEVVDINDNAPEFEQ 244
Score = 58.0 bits (134), Expect = 2e-07
Identities = 60/218 (27%), Positives = 87/218 (39%), Gaps = 18/218 (8%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+++ N A Q + EN I ++A D DSG N Q+ Y +PP
Sbjct: 439 VQISDVNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSL-----LPP 493
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVF 1034
L + IN +GH+ RSL E+ F + A D G+ L+ VRV
Sbjct: 494 QD---PHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPALSREALVRVL 550
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQPSD 1088
V D ND+ P N + + R ++ KV A D D GQNA L+Y + +
Sbjct: 551 VLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKAT 610
Query: 1089 TDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
F + G + L K L V+ +DNG
Sbjct: 611 EPGLFGVWAHNGEVRTARLLSERDAAKQRLVVLVKDNG 648
Score = 57.6 bits (133), Expect = 3e-07
Identities = 86/364 (23%), Positives = 141/364 (38%), Gaps = 51/364 (14%)
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD----TD 1090
V D+NDH P+F + + E A D D G N Y I PS
Sbjct: 123 VIDINDHSPMFTEKEMILKIPENSPLGTEFPLNHALDLDVGSNNVQNYKISPSSHFRVLI 182
Query: 1091 LPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
F L ++ ELDRE E + LT+ A D G D+NDN+P+
Sbjct: 183 HEFRDGRKYPELVLDKELDREEEPQLRLTLTALDGG-SPPRSGTAQVRIEVVDINDNAPE 241
Query: 1151 FYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNG 1210
F + P +YK I EN+P+G+ VA V A D D G
Sbjct: 242 F---------EQP-----------------IYKVQIPENSPLGSLVATVSARDLD--GGA 273
Query: 1211 NGLILYSL--PQRKNQQNLGLPSLSSTAIL-------MVTVADV----PDEVEMSDKPVF 1257
NG I Y+L P + L + ++ L MVT +V D +S K
Sbjct: 274 NGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIKATDGGGLSGKCTL 333
Query: 1258 ISRYYELEIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYL 1317
+ + ++ + + ++ + E+ + + +++ D+ + + +L
Sbjct: 334 LLQVVDVN-DNPPQVTMSALTSPIPENSPEIVVAVFSVSDPDSGNNGKTISSIQEDLPFL 392
Query: 1318 VRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNS 1377
++ VK+ Y ++ + +R + I D+ K + + V+I DVNDN+
Sbjct: 393 LKP---SVKNFYTLVTERALDREAR-AEYNITLTVTDMGTPRLKTEHNITVQISDVNDNA 448
Query: 1378 PKFT 1381
P FT
Sbjct: 449 PTFT 452
Score = 54.8 bits (126), Expect = 2e-06
Identities = 71/291 (24%), Positives = 112/291 (38%), Gaps = 16/291 (5%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPI-- 124
L + G S V + + D+NDN P F Y V + E +P G +
Sbjct: 212 LTALDGGSPPRSGTAQVRIEVVDINDNAPEFEQPIYKVQIPENSPLGSLVATVSARDLDG 271
Query: 125 GPSLTIPLTVPR-GLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALES---SHKP 180
G + I T+ + I K + V + +V+ + A + S K
Sbjct: 272 GANGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIKATDGGGLSGKC 331
Query: 181 VLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND 240
LLL+ V D D Q+ + A I + PE + A+ + + IS
Sbjct: 332 TLLLQVV---DVNDNPPQVTMSALTSPIPENS--PEIVVAVFSVSDPDSGNNGKTISSIQ 386
Query: 241 RKL-FSLD-SVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
L F L SV L E LD E + N + + + + P + + +++ D
Sbjct: 387 EDLPFLLKPSVKNFYTLVTERALDREARAEYN---ITLTVTDMGTPRLKTEHNITVQISD 443
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
+NDN P F Y + + EN + V ATD+D G N + TY L P+
Sbjct: 444 VNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQ 494
Score = 48.0 bits (109), Expect = 3e-04
Identities = 48/172 (27%), Positives = 79/172 (45%), Gaps = 14/172 (8%)
Query: 221 IDQDLGVG----ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ +DLG+G +T + +IS +++ L + G L + ++LD + E +L
Sbjct: 48 LGKDLGLGLTEMSTRKARIISQGNKQHLQLKAQTGDLLINEKLDRE-ELCGPTEPCILHF 106
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
Q + NPL+ QA E+ ++D+ND+ P F + I EN P G A D D G
Sbjct: 107 QVL-MENPLEIFQA--ELRVIDINDHSPMFTEKEMILKIPENSPLGTEFPLNHALDLDVG 163
Query: 337 ENGEFTYQLDDPKGAFSI---DPRSG--WLTVRNQTVLDREAHSSLRMKVYA 383
N Y++ P F + + R G + + LDRE LR+ + A
Sbjct: 164 SNNVQNYKI-SPSSHFRVLIHEFRDGRKYPELVLDKELDREEEPQLRLTLTA 214
Score = 47.6 bits (108), Expect = 3e-04
Identities = 62/235 (26%), Positives = 94/235 (40%), Gaps = 14/235 (5%)
Query: 444 NVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL--QR 501
N+ V + D NDN P F ++ Y ++ N IG V A D D G N V Y L +
Sbjct: 436 NITVQISDVNDNAPTFTQTS-YTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQ 494
Query: 502 TSNLTITSPFKINPNTGTVSVAESPILEGRHAL-FVEASDQPANPSERRYSLAVVTIEVT 560
+L + S IN + G + S E A F + +P+ R +L V +
Sbjct: 495 DPHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPALSREALVRVLV--- 551
Query: 561 RGTKGNKPDI--PDFMG-APYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYE 615
N P + P G AP V G V ++ D+ + +SY LL E
Sbjct: 552 LDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATE 611
Query: 616 EGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
G+ F V +G + LS + V +++N AT+HV+ V+
Sbjct: 612 PGL-FGVWAHNGEVRTARLLSERDAAKQRL-VVLVKDNGEPPRSATATLHVLLVD 664
Score = 41.9 bits (94), Expect = 0.017
Identities = 35/161 (21%), Positives = 72/161 (44%), Gaps = 12/161 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGND--RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A D D G + Y L ++ K ++ + G + L K++D + ++ ++
Sbjct: 264 VSARDLDGGANGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFE-----MVTSYEVR 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
++A+ + + + ++++D+NDN P+ + I EN P V +D D
Sbjct: 319 IKATDGGG--LSGKCTLLLQVVDVNDNPPQVTMSALTSPIPENSPE-IVVAVFSVSDPDS 375
Query: 336 GENGEFTYQLDDPKGAFSIDPR-SGWLTVRNQTVLDREAHS 375
G NG+ + + F + P + T+ + LDREA +
Sbjct: 376 GNNGKTISSIQEDL-PFLLKPSVKNFYTLVTERALDREARA 415
>AF240635-1|AAF73962.1| 1184|Homo sapiens vascular endothelial
cadherin 2 protein.
Length = 1184
Score = 103 bits (247), Expect = 5e-21
Identities = 127/545 (23%), Positives = 225/545 (41%), Gaps = 32/545 (5%)
Query: 440 MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
++ ++VE+ +LD ND+ P F P E + +A + T I +A+DPD G N + Y L
Sbjct: 116 LALIHVEIQVLDINDHQPRF-PKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTL 174
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILEGRHALF--VEASDQPANPSERRYSLAVVTI 557
+ + + + + + H+ F V + NP + SL V +
Sbjct: 175 SPSEHFALDVIVGPDETKHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNV 234
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGYE 615
+ + P F + + + GT + ++ D + +V + L
Sbjct: 235 ------LDSNDNSPAFAESSLALEIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMP 288
Query: 616 EGV--PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDE 672
V F+++ ++G + + L P Y+ + A N + + V+DVND
Sbjct: 289 PEVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQARDLGPNPIPAHCKVLIKVLDVNDN 348
Query: 673 -RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
+ + A P + + + I + ++ S + NG + +L
Sbjct: 349 IPSIHVTWASQPSLVS-EALPKDSFIALVMADDLDSGH-NGLVHC-WLSQELGHFRLKRT 405
Query: 732 IAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
+ T LDRE+ Y +T++A+ ++G+ + Q++I I D NDN PVFE +
Sbjct: 406 NGNTYMLLTNATLDREQWPKYTLTLLAQ-DQGLQPLSAKKQLSIQISDINDNAPVFEKSR 464
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG-KEMFDVDENTGVVKFIG 850
YE EN+ + IKA DAD G N Y + + +D NTG V
Sbjct: 465 YEVSTRENNLPSLHL---ITIKAHDADLGINGKVSYRIQDSPVAHLVAIDSNTGEVT-AQ 520
Query: 851 DSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ-IEENSKVRIHRE 907
SL+ E+ ++ ++A D+G L+S + + + D NDN PE Q + + K +
Sbjct: 521 RSLNYEEMAGFEFQVIAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASL--S 578
Query: 908 TKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIR 967
+N + G ++ ++ N PL + TTI+ A D DSG NG+
Sbjct: 579 VLVNASTGHLLVPIETPNGLGPAGTDTPPLATHSSRPFLLTTIV---ARDADSGANGEPL 635
Query: 968 YEFNS 972
Y S
Sbjct: 636 YSIRS 640
Score = 89.8 bits (213), Expect = 6e-17
Identities = 117/426 (27%), Positives = 179/426 (42%), Gaps = 53/426 (12%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
+E+G + T + LDRE+ + F+ + V I + D ND+ P F
Sbjct: 81 SEEGLLSTGRRLDREQLCRQWDPCLVSFDVLATGDLALIHVEIQVLDINDHQPRFPKGEQ 140
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDS 852
E I E++ + T I +D +A D D G N L YTL E F +D G
Sbjct: 141 ELEISESASLRTRIPLD---RALDPDTGPNTLHTYTL--SPSEHFALDVIVGP------- 188
Query: 853 LDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNG 912
D K +L +V + S +L++ D N N P+ S V+++ +
Sbjct: 189 -DETKHA--ELIVVKELDREIHSFFDLVLTAYD-NGNPPKSG----TSLVKVNVLDSNDN 240
Query: 913 TAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNS 972
+ F ++ AL++ E+ GT +IKL A D D G NG++ EF
Sbjct: 241 SPAFA------ESSLALEIQ---------EDAAPGTLLIKLTATDPDQGPNGEV--EFFL 283
Query: 973 EVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALD-GGN-LNDN 1028
++PP EV F I+ + G VI+ R L E + +++ A D G N + +
Sbjct: 284 SKHMPP--------EVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQARDLGPNPIPAH 335
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYN--FNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQP 1086
V + V DVND+ P TW + V EA + V A D D G N + ++
Sbjct: 336 CKVLIKVLDVNDNIPSIHVTWASQPSLVSEALPKDSFIALVMADDLDSGHNGLVHCWLSQ 395
Query: 1087 SDTDLPFE-ISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ + T +L N LDRE KY LT++A+D G D+N
Sbjct: 396 ELGHFRLKRTNGNTYMLLTNATLDREQWPKYTLTLLAQDQG-LQPLSAKKQLSIQISDIN 454
Query: 1146 DNSPKF 1151
DN+P F
Sbjct: 455 DNAPVF 460
Score = 72.9 bits (171), Expect = 8e-12
Identities = 124/506 (24%), Positives = 205/506 (40%), Gaps = 66/506 (13%)
Query: 997 RHGHVIVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+H +IV + L E S F L ++A D GN + V+V V D ND+ P F ++
Sbjct: 192 KHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLAL 251
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTDLPFEISPLTGVLSVNGELD 1109
++E +L K+ ATD D G N + +F+ P + F I TG + + LD
Sbjct: 252 EIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQVILRRPLD 311
Query: 1110 RETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEW-KHPE--AD 1166
E Y + V ARD G DVNDN P + + W P ++
Sbjct: 312 YEKNPAYEVDVQARDLG-PNPIPAHCKVLIKVLDVNDNIPSIH-----VTWASQPSLVSE 365
Query: 1167 ELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNG-LILYSLPQRKNQ- 1224
L +F +++M + N + +++ + NGN ++L + + Q
Sbjct: 366 ALPKDSFIALVMADDLDS--GHNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDREQW 423
Query: 1225 ---------QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVE 1275
Q+ GL LS+ L + ++D+ D + PVF YE+ EN +
Sbjct: 424 PKYTLTLLAQDQGLQPLSAKKQLSIQISDIND-----NAPVFEKSRYEVSTRENNLPSLH 478
Query: 1276 LVSLNL--TEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIV 1333
L+++ + N K+ Y I D+ + ID G + RS + E +E V
Sbjct: 479 LITIKAHDADLGINGKVSYRI---QDSPVAHLVAIDSNTGEVTAQRSLNYEEMAGFEFQV 535
Query: 1334 RAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTN---GNRPLVTA 1390
+AED + M V V V + D NDN+P+ + +
Sbjct: 536 -----------------IAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASLS 578
Query: 1391 IPTTAPFGYQVMQLKGAIGHHPTASRTVRADTDELVFFERLSLNGLTSPQATDSDIGINA 1450
+ A G+ ++ ++ G P + T T R L LT+ A D+D G N
Sbjct: 579 VLVNASTGHLLVPIETPNGLGPAGTDTPPLATHS----SRPFL--LTTIVARDADSGANG 632
Query: 1451 DIRYQILN-EQAPRFAIDPVSGTVRV 1475
+ Y I + +A F ++P +G + V
Sbjct: 633 EPLYSIRSGNEAHLFILNPHTGQLFV 658
Score = 64.9 bits (151), Expect = 2e-09
Identities = 129/540 (23%), Positives = 213/540 (39%), Gaps = 49/540 (9%)
Query: 31 HVSVILAQSIDSLVDSDSPQNVVKFRLGCDFDEGDDLVRIGA--GLNQISAYLSVTVYIE 88
H +I+ + +D + S + + G G LV++ + A+ ++ +E
Sbjct: 193 HAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALE 252
Query: 89 DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSL--TIPLTVPRGLTIFKDIRA 146
D P L T + P GE F FL + P + T + G I + R
Sbjct: 253 IQEDAAPGTLLIKLTATDPDQGPNGEVEF-FLSKHMPPEVLDTFSIDAKTGQVILR--RP 309
Query: 147 FDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGK 206
D +K P +V V D G + + H VL+ KVLD + V AS
Sbjct: 310 LDYEK--NPAYEVD---VQARDLGPNPIPA-HCKVLI--KVLDVNDNIPSIH-VTWASQP 360
Query: 207 RIHKEILFPEPIHAI--DQDLGVGATLRYELISGNDRKLFSLDSVNGSLF-LEKELDLDA 263
+ E L + A+ DL G + F L NG+ + L LD
Sbjct: 361 SLVSEALPKDSFIALVMADDLDSGHNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDR 420
Query: 264 EHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGF 323
E T L Q L PL +A+ ++ I++ D+NDN P FE Y +S EN
Sbjct: 421 EQ-WPKYTLTLLAQDQGLQ-PL-SAKKQLSIQISDINDNAPVFEKSRYEVSTRENNLPSL 477
Query: 324 SVLQVMATDKDQGENGEFTYQLDDPKGA--FSIDPRSGWLTVRNQTVLDREAHSSLRMKV 381
++ + A D D G NG+ +Y++ D A +ID +G +T Q L+ E + +V
Sbjct: 478 HLITIKAHDADLGINGKVSYRIQDSPVAHLVAIDSNTGEVTA--QRSLNYEEMAGFEFQV 535
Query: 382 YAKETNPSVVGTFADSQRIAKW-RRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLM 440
A+++ ++ + ++ W NAP E V D + + + L+
Sbjct: 536 IAEDSGQPML-----ASSVSVWVSLLDANDNAP-EVVQPVLSDGKASLSVLVNASTGHLL 589
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
+ L A + P + F + T++ + D D G NG LY ++
Sbjct: 590 VPIETPNGLGPAGTDTPPLATHSSRPFLLT------TIVAR----DADSGANGEPLYSIR 639
Query: 501 RTSNLTITSPFKINPNTGT--VSVAESPILEGRH-ALFVEASDQPANPSERRYSLAVVTI 557
+ + F +NP+TG V+V + L G L + DQ + P + R L V+ +
Sbjct: 640 SGNEAHL---FILNPHTGQLFVNVTNASSLIGSEWELEIVVEDQGSPPLQTRALLRVMFV 696
Score = 62.1 bits (144), Expect = 1e-08
Identities = 76/337 (22%), Positives = 145/337 (43%), Gaps = 37/337 (10%)
Query: 579 EFWVGSNVGIGTSVGQIRVNDAFE----QNDVSYDLLHGYEEGVPFAVEERSGVITVVDD 634
++ V V GT +G++ E Q ++ +L + +P V+ G+++
Sbjct: 33 KYQVSEEVPSGTVIGKLSQELGREERRRQAGAAFQVLQ-LPQALPIQVDSEEGLLSTGRR 91
Query: 635 LSR------YNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHV 688
L R ++ + F+ +A +L+++ + + V+D+ND + KG
Sbjct: 92 LDREQLCRQWDPCLVSFDVLA---TGDLALI-HVEIQVLDINDHQPRFPKGEQE------ 141
Query: 689 KENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLIANQQDVTDDIAIAEDGT----IFTQKP 743
E S A++ + + G + + ++ + D+ + D T + K
Sbjct: 142 LEISESASLRTRIPLDRALDPDTGPNTLHTYTLSPSEHFALDVIVGPDETKHAELIVVKE 201
Query: 744 LDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIG 803
LDRE + + V+ ++ G +G V + + D NDN P F ++ I E++ G
Sbjct: 202 LDREIHSFFDL-VLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALEIQEDAAPG 260
Query: 804 TEIKMDNIIKATDADEGTNALFMYTLF----GEGKEMFDVDENTGVVKFIGDSLDREKKI 859
T + + ATD D+G N + L E + F +D TG V + LD EK
Sbjct: 261 TLLIK---LTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQV-ILRRPLDYEKNP 316
Query: 860 MYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFN 894
Y++ + ARD G + + +++I + D NDN P +
Sbjct: 317 AYEVDVQARDLGPNPIPAHCKVLIKVLDVNDNIPSIH 353
Score = 40.3 bits (90), Expect = 0.052
Identities = 35/112 (31%), Positives = 50/112 (44%), Gaps = 7/112 (6%)
Query: 288 AQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD 347
A VEI++LD+ND+ P F + I E+ + A D D G N TY L
Sbjct: 117 ALIHVEIQVLDINDHQPRFPKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTL-S 175
Query: 348 PKGAFSIDPRSGWLTVRNQTV-----LDREAHSSLRMKVYAKET-NPSVVGT 393
P F++D G ++ + LDRE HS + + A + NP GT
Sbjct: 176 PSEHFALDVIVGPDETKHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGT 227
>AF231025-1|AAF61931.1| 1184|Homo sapiens protocadherin 12 protein.
Length = 1184
Score = 103 bits (247), Expect = 5e-21
Identities = 127/545 (23%), Positives = 225/545 (41%), Gaps = 32/545 (5%)
Query: 440 MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
++ ++VE+ +LD ND+ P F P E + +A + T I +A+DPD G N + Y L
Sbjct: 116 LALIHVEIQVLDINDHQPRF-PKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTL 174
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILEGRHALF--VEASDQPANPSERRYSLAVVTI 557
+ + + + + + H+ F V + NP + SL V +
Sbjct: 175 SPSEHFALDVIVGPDETKHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNV 234
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGYE 615
+ + P F + + + GT + ++ D + +V + L
Sbjct: 235 ------LDSNDNSPAFAESSLALEIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMP 288
Query: 616 EGV--PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDE 672
V F+++ ++G + + L P Y+ + A N + + V+DVND
Sbjct: 289 PEVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQARDLGPNPIPAHCKVLIKVLDVNDN 348
Query: 673 -RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
+ + A P + + + I + ++ S + NG + +L
Sbjct: 349 IPSIHVTWASQPSLVS-EALPKDSFIALVMADDLDSGH-NGLVHC-WLSQELGHFRLKRT 405
Query: 732 IAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
+ T LDRE+ Y +T++A+ ++G+ + Q++I I D NDN PVFE +
Sbjct: 406 NGNTYMLLTNATLDREQWPKYTLTLLAQ-DQGLQPLSAKKQLSIQISDINDNAPVFEKSR 464
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG-KEMFDVDENTGVVKFIG 850
YE EN+ + IKA DAD G N Y + + +D NTG V
Sbjct: 465 YEVSTRENNLPSLHL---ITIKAHDADLGINGKVSYRIQDSPVAHLVAIDSNTGEVT-AQ 520
Query: 851 DSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ-IEENSKVRIHRE 907
SL+ E+ ++ ++A D+G L+S + + + D NDN PE Q + + K +
Sbjct: 521 RSLNYEEMAGFEFQVIAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASL--S 578
Query: 908 TKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIR 967
+N + G ++ ++ N PL + TTI+ A D DSG NG+
Sbjct: 579 VLVNASTGHLLVPIETPNGLGPAGTDTPPLATHSSRPFLLTTIV---ARDADSGANGEPL 635
Query: 968 YEFNS 972
Y S
Sbjct: 636 YSIRS 640
Score = 89.8 bits (213), Expect = 6e-17
Identities = 117/426 (27%), Positives = 179/426 (42%), Gaps = 53/426 (12%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
+E+G + T + LDRE+ + F+ + V I + D ND+ P F
Sbjct: 81 SEEGLLSTGRRLDREQLCRQWDPCLVSFDVLATGDLALIHVEIQVLDINDHQPRFPKGEQ 140
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDS 852
E I E++ + T I +D +A D D G N L YTL E F +D G
Sbjct: 141 ELEISESASLRTRIPLD---RALDPDTGPNTLHTYTL--SPSEHFALDVIVGP------- 188
Query: 853 LDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNG 912
D K +L +V + S +L++ D N N P+ S V+++ +
Sbjct: 189 -DETKHA--ELIVVKELDREIHSFFDLVLTAYD-NGNPPKSG----TSLVKVNVLDSNDN 240
Query: 913 TAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNS 972
+ F ++ AL++ E+ GT +IKL A D D G NG++ EF
Sbjct: 241 SPAFA------ESSLALEIQ---------EDAAPGTLLIKLTATDPDQGPNGEV--EFFL 283
Query: 973 EVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALD-GGN-LNDN 1028
++PP EV F I+ + G VI+ R L E + +++ A D G N + +
Sbjct: 284 SKHMPP--------EVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQARDLGPNPIPAH 335
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYN--FNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQP 1086
V + V DVND+ P TW + V EA + V A D D G N + ++
Sbjct: 336 CKVLIKVLDVNDNIPSIHVTWASQPSLVSEALPKDSFIALVMADDLDSGHNGLVHCWLSQ 395
Query: 1087 SDTDLPFE-ISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ + T +L N LDRE KY LT++A+D G D+N
Sbjct: 396 ELGHFRLKRTNGNTYMLLTNATLDREQWPKYTLTLLAQDQG-LQPLSAKKQLSIQISDIN 454
Query: 1146 DNSPKF 1151
DN+P F
Sbjct: 455 DNAPVF 460
Score = 72.9 bits (171), Expect = 8e-12
Identities = 124/506 (24%), Positives = 205/506 (40%), Gaps = 66/506 (13%)
Query: 997 RHGHVIVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+H +IV + L E S F L ++A D GN + V+V V D ND+ P F ++
Sbjct: 192 KHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLAL 251
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTDLPFEISPLTGVLSVNGELD 1109
++E +L K+ ATD D G N + +F+ P + F I TG + + LD
Sbjct: 252 EIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQVILRRPLD 311
Query: 1110 RETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEW-KHPE--AD 1166
E Y + V ARD G DVNDN P + + W P ++
Sbjct: 312 YEKNPAYEVDVQARDLG-PNPIPAHCKVLIKVLDVNDNIPSIH-----VTWASQPSLVSE 365
Query: 1167 ELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNG-LILYSLPQRKNQ- 1224
L +F +++M + N + +++ + NGN ++L + + Q
Sbjct: 366 ALPKDSFIALVMADDLDS--GHNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDREQW 423
Query: 1225 ---------QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVE 1275
Q+ GL LS+ L + ++D+ D + PVF YE+ EN +
Sbjct: 424 PKYTLTLLAQDQGLQPLSAKKQLSIQISDIND-----NAPVFEKSRYEVSTRENNLPSLH 478
Query: 1276 LVSLNL--TEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIV 1333
L+++ + N K+ Y I D+ + ID G + RS + E +E V
Sbjct: 479 LITIKAHDADLGINGKVSYRI---QDSPVAHLVAIDSNTGEVTAQRSLNYEEMAGFEFQV 535
Query: 1334 RAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTN---GNRPLVTA 1390
+AED + M V V V + D NDN+P+ + +
Sbjct: 536 -----------------IAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASLS 578
Query: 1391 IPTTAPFGYQVMQLKGAIGHHPTASRTVRADTDELVFFERLSLNGLTSPQATDSDIGINA 1450
+ A G+ ++ ++ G P + T T R L LT+ A D+D G N
Sbjct: 579 VLVNASTGHLLVPIETPNGLGPAGTDTPPLATHS----SRPFL--LTTIVARDADSGANG 632
Query: 1451 DIRYQILN-EQAPRFAIDPVSGTVRV 1475
+ Y I + +A F ++P +G + V
Sbjct: 633 EPLYSIRSGNEAHLFILNPHTGQLFV 658
Score = 64.9 bits (151), Expect = 2e-09
Identities = 129/540 (23%), Positives = 213/540 (39%), Gaps = 49/540 (9%)
Query: 31 HVSVILAQSIDSLVDSDSPQNVVKFRLGCDFDEGDDLVRIGA--GLNQISAYLSVTVYIE 88
H +I+ + +D + S + + G G LV++ + A+ ++ +E
Sbjct: 193 HAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALE 252
Query: 89 DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSL--TIPLTVPRGLTIFKDIRA 146
D P L T + P GE F FL + P + T + G I + R
Sbjct: 253 IQEDAAPGTLLIKLTATDPDQGPNGEVEF-FLSKHMPPEVLDTFSIDAKTGQVILR--RP 309
Query: 147 FDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGK 206
D +K P +V V D G + + H VL+ KVLD + V AS
Sbjct: 310 LDYEK--NPAYEVD---VQARDLGPNPIPA-HCKVLI--KVLDVNDNIPSIH-VTWASQP 360
Query: 207 RIHKEILFPEPIHAI--DQDLGVGATLRYELISGNDRKLFSLDSVNGSLF-LEKELDLDA 263
+ E L + A+ DL G + F L NG+ + L LD
Sbjct: 361 SLVSEALPKDSFIALVMADDLDSGHNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDR 420
Query: 264 EHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGF 323
E T L Q L PL +A+ ++ I++ D+NDN P FE Y +S EN
Sbjct: 421 EQ-WPKYTLTLLAQDQGLQ-PL-SAKKQLSIQISDINDNAPVFEKSRYEVSTRENNLPSL 477
Query: 324 SVLQVMATDKDQGENGEFTYQLDDPKGA--FSIDPRSGWLTVRNQTVLDREAHSSLRMKV 381
++ + A D D G NG+ +Y++ D A +ID +G +T Q L+ E + +V
Sbjct: 478 HLITIKAHDADLGINGKVSYRIQDSPVAHLVAIDSNTGEVTA--QRSLNYEEMAGFEFQV 535
Query: 382 YAKETNPSVVGTFADSQRIAKW-RRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLM 440
A+++ ++ + ++ W NAP E V D + + + L+
Sbjct: 536 IAEDSGQPML-----ASSVSVWVSLLDANDNAP-EVVQPVLSDGKASLSVLVNASTGHLL 589
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
+ L A + P + F + T++ + D D G NG LY ++
Sbjct: 590 VPIETPNGLGPAGTDTPPLATHSSRPFLLT------TIVAR----DADSGANGEPLYSIR 639
Query: 501 RTSNLTITSPFKINPNTGT--VSVAESPILEGRH-ALFVEASDQPANPSERRYSLAVVTI 557
+ + F +NP+TG V+V + L G L + DQ + P + R L V+ +
Sbjct: 640 SGNEAHL---FILNPHTGQLFVNVTNASSLIGSEWELEIVVEDQGSPPLQTRALLRVMFV 696
Score = 62.1 bits (144), Expect = 1e-08
Identities = 76/337 (22%), Positives = 145/337 (43%), Gaps = 37/337 (10%)
Query: 579 EFWVGSNVGIGTSVGQIRVNDAFE----QNDVSYDLLHGYEEGVPFAVEERSGVITVVDD 634
++ V V GT +G++ E Q ++ +L + +P V+ G+++
Sbjct: 33 KYQVSEEVPSGTVIGKLSQELGREERRRQAGAAFQVLQ-LPQALPIQVDSEEGLLSTGRR 91
Query: 635 LSR------YNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHV 688
L R ++ + F+ +A +L+++ + + V+D+ND + KG
Sbjct: 92 LDREQLCRQWDPCLVSFDVLA---TGDLALI-HVEIQVLDINDHQPRFPKGEQE------ 141
Query: 689 KENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLIANQQDVTDDIAIAEDGT----IFTQKP 743
E S A++ + + G + + ++ + D+ + D T + K
Sbjct: 142 LEISESASLRTRIPLDRALDPDTGPNTLHTYTLSPSEHFALDVIVGPDETKHAELIVVKE 201
Query: 744 LDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIG 803
LDRE + + V+ ++ G +G V + + D NDN P F ++ I E++ G
Sbjct: 202 LDREIHSFFDL-VLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALEIQEDAAPG 260
Query: 804 TEIKMDNIIKATDADEGTNALFMYTLF----GEGKEMFDVDENTGVVKFIGDSLDREKKI 859
T + + ATD D+G N + L E + F +D TG V + LD EK
Sbjct: 261 TLLIK---LTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQV-ILRRPLDYEKNP 316
Query: 860 MYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFN 894
Y++ + ARD G + + +++I + D NDN P +
Sbjct: 317 AYEVDVQARDLGPNPIPAHCKVLIKVLDVNDNIPSIH 353
Score = 40.3 bits (90), Expect = 0.052
Identities = 35/112 (31%), Positives = 50/112 (44%), Gaps = 7/112 (6%)
Query: 288 AQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD 347
A VEI++LD+ND+ P F + I E+ + A D D G N TY L
Sbjct: 117 ALIHVEIQVLDINDHQPRFPKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTL-S 175
Query: 348 PKGAFSIDPRSGWLTVRNQTV-----LDREAHSSLRMKVYAKET-NPSVVGT 393
P F++D G ++ + LDRE HS + + A + NP GT
Sbjct: 176 PSEHFALDVIVGPDETKHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGT 227
>AB209225-1|BAD92462.1| 799|Homo sapiens protocadherin beta 11
precursor variant protein.
Length = 799
Score = 103 bits (247), Expect = 5e-21
Identities = 111/465 (23%), Positives = 190/465 (40%), Gaps = 36/465 (7%)
Query: 442 FVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQR 501
F+ +E+ + D ND++P+F + + N+ VG V A D D+G N + Y +
Sbjct: 118 FLQIELQVRDINDHSPIFSEKQML-LEIPENSPVGAVFLLESAKDLDVGINAVKSYTISP 176
Query: 502 TSNLTITSPFKINPNTGTVSVAESPILEGRH----ALFVEASDQPANPSERRYSLAVVTI 557
S+ I I N + L+ + + A D + P + VV +
Sbjct: 177 NSHFHIKMRV-IPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVVVV 235
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYE 615
++ + P+F A YE + N +G+ + + D+ ++ Y H E
Sbjct: 236 DINDNS-------PEFEQAFYEVKIRENSILGSLILIVSAWDLDSGTNGEICYTFSHASE 288
Query: 616 E-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERG 674
+ F + ++SG IT+ L Y + + L + +HV+DVND
Sbjct: 289 DIRKTFEINQKSGEITLRAPLDFETIESYSI-IIQATDGGGLFGKSTVIIHVIDVNDNAP 347
Query: 675 VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAE 734
+ S I + EN+ + +F ++ I G + I ++
Sbjct: 348 EI---TVSSITSPIPENTPETVV-MVF--SIQDIDSGDNGRIVCSIPEDLPFVLKSSVEN 401
Query: 735 DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEG 794
T+ T++PLDRE Y +T+ + G+ + T+ + D NDN P F +Y
Sbjct: 402 YHTLETERPLDRESTAEYNITITVT-DLGIPRLKTEHNTTVLVSDVNDNAPTFTQTSYTL 460
Query: 795 FIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDENTGVVKF 848
F+ EN+ I + ATD D GTNA Y+L + ++ + G + F
Sbjct: 461 FVRENNSPALHI---GSVSATDRDSGTNAQVNYSLLPPQDLHLPLASLVSINTDNGHL-F 516
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
SLD E + + A D G LSSEA + +++ D NDN P
Sbjct: 517 ALRSLDYEALQAFDFRVGATDRGSPALSSEALVRVLVLDANDNSP 561
Score = 101 bits (242), Expect = 2e-20
Identities = 129/528 (24%), Positives = 218/528 (41%), Gaps = 59/528 (11%)
Query: 904 IHRETKLNGTAGFTIIEVKPK--NKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSG 961
+H + + F IE++ + N + + L IPEN P+G + +A DLD G
Sbjct: 106 LHLQVLMQNPTQFLQIELQVRDINDHSPIFSEKQMLLEIPENSPVGAVFLLESAKDLDVG 165
Query: 962 LNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISA 1019
+N Y + P S R N ++ +++ ++L E E +SA
Sbjct: 166 INAVKSYTIS-----PNSHFHIKM----RVIPDNRKYPELVLDKALDYEELPELSFILSA 216
Query: 1020 LDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQN 1077
LDGG+ + VRV V D+ND+ P F++ +Y + E ++ V A D D G N
Sbjct: 217 LDGGSPPRSGTALVRVVVVDINDNSPEFEQAFYEVKIRENSILGSLILIVSAWDLDSGTN 276
Query: 1078 ANLTYFIQPSDTDL--PFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXX 1135
+ Y + D+ FEI+ +G +++ LD ET + Y + + A D G
Sbjct: 277 GEICYTFSHASEDIRKTFEINQKSGEITLRAPLDFETIESYSIIIQATDGG---GLFGKS 333
Query: 1136 XXXXXXXDVNDNSPKF--YAFDELLEWKHPEADEL--SNHNFESVMMIPVYKATIEENAP 1191
DVNDN+P+ + + PE + S + +S + +I E+ P
Sbjct: 334 TVIIHVIDVNDNAPEITVSSITSPIPENTPETVVMVFSIQDIDSGDNGRIV-CSIPEDLP 392
Query: 1192 --IGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEV 1249
+ ++V +T+ + Y++ +LG+P L + V V+DV D
Sbjct: 393 FVLKSSVENYHTLETERPLDRESTAEYNI--TITVTDLGIPRLKTEHNTTVLVSDVND-- 448
Query: 1250 EMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV 1307
+ P F Y L + EN + + + S++ T+ N ++ Y +L D + +
Sbjct: 449 ---NAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVNYSLLPPQDLHLPLASL 505
Query: 1308 --IDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVK 1365
I+ NG L+ +RS D E ++ V A R P + +
Sbjct: 506 VSINTDNGHLFALRSLDYEALQAFDFRVGAT----DRGSPAL-------------SSEAL 548
Query: 1366 VVVRIKDVNDNSP----KFTNGNRPLVTAIPTTAPFGYQVMQLKGAIG 1409
V V + D NDNSP NG+ P +P A GY V ++ G
Sbjct: 549 VRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDG 596
Score = 76.2 bits (179), Expect = 9e-13
Identities = 85/325 (26%), Positives = 140/325 (43%), Gaps = 31/325 (9%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPI--GPSLTIPLTVPRGLT 139
+V +++ DVNDN P + + E TP +F I I G + I ++P L
Sbjct: 334 TVIIHVIDVNDNAPEITVSSITSPIPENTPE-TVVMVFSIQDIDSGDNGRIVCSIPEDLP 392
Query: 140 IF-----KDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
++ + ++P S Y+I ++ D G L++ H +L+ V D
Sbjct: 393 FVLKSSVENYHTLETERPLDRESTAEYNITITVTDLGIPRLKTEHNTTVLVSDVNDNAPT 452
Query: 194 DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLFSLDS 248
+ + + + L + A D+D G A + Y L+ D L S+++
Sbjct: 453 FTQTSYTLFV--RENNSPALHIGSVSATDRDSGTNAQVNYSLLPPQDLHLPLASLVSINT 510
Query: 249 VNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEV 308
NG LF + LD +A LQA F +V A+ +P +++A V + +LD NDN P
Sbjct: 511 DNGHLFALRSLDYEA---LQA--FDFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLY 565
Query: 309 DFYNISI--VENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGW 360
N S E +P G+ V +V+A D D G+N +YQL G F + +G
Sbjct: 566 PLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG- 624
Query: 361 LTVRNQTVLDREAHSSLRMKVYAKE 385
VR +L + R+ V K+
Sbjct: 625 -EVRTARLLSERDAAKHRLVVLVKD 648
Score = 74.9 bits (176), Expect = 2e-12
Identities = 62/236 (26%), Positives = 111/236 (47%), Gaps = 17/236 (7%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLIAN 722
+ V D+ND + + ++ + ENS +G +F + G V+ + I+
Sbjct: 123 LQVRDINDHSPIF---SEKQMLLEIPENSP---VGAVFLLESAKDLDVGINAVKSYTISP 176
Query: 723 QQDVTDDIAIAEDGTIFTQKPLDR--EKRDVYRMT-VIAEFNKGVISGAGIYQVTIYIED 779
+ + D + + LD+ + ++ ++ +++ + G +G V + + D
Sbjct: 177 NSHFHIKMRVIPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVVVVD 236
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM--- 836
NDN P FE A YE I ENS +G+ I I+ A D D GTN YT +++
Sbjct: 237 INDNSPEFEQAFYEVKIRENSILGSLIL---IVSAWDLDSGTNGEICYTFSHASEDIRKT 293
Query: 837 FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
F++++ +G + + LD E Y + + A D GGL ++ +II + D NDN PE
Sbjct: 294 FEINQKSGEIT-LRAPLDFETIESYSIIIQATDGGGLFGKSTVIIHVIDVNDNAPE 348
Score = 68.1 bits (159), Expect = 2e-10
Identities = 57/175 (32%), Positives = 86/175 (49%), Gaps = 17/175 (9%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGS-----LFLEKELDLDAEHNLQANTFVL 274
A D D+G+ A Y IS N + + + L L+K LD + L +F+L
Sbjct: 159 AKDLDVGINAVKSYT-ISPNSHFHIKMRVIPDNRKYPELVLDKALDYE---ELPELSFIL 214
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
A +P ++ A V + ++D+NDN PEFE FY + I EN G +L V A D D
Sbjct: 215 S--ALDGGSPPRSGTALVRVVVVDINDNSPEFEQAFYEVKIRENSILGSLILIVSAWDLD 272
Query: 335 QGENGE----FTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
G NGE F++ +D + F I+ +SG +T+R LD E S + + A +
Sbjct: 273 SGTNGEICYTFSHASEDIRKTFEINQKSGEITLR--APLDFETIESYSIIIQATD 325
Score = 62.1 bits (144), Expect = 1e-08
Identities = 64/220 (29%), Positives = 89/220 (40%), Gaps = 18/220 (8%)
Query: 917 TIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYI 976
T + V N A Q + EN I ++A D DSG N Q+ Y +
Sbjct: 439 TTVLVSDVNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVNYSL-----L 493
Query: 977 PPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVR 1032
PP L L + IN +GH+ RSL E+ F + A D G+ L+ VR
Sbjct: 494 PPQDLH---LPLASLVSINTDNGHLFALRSLDYEALQAFDFRVGATDRGSPALSSEALVR 550
Query: 1033 VFVKDVNDHFPVFKKTWYNFN------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQP 1086
V V D ND+ P N + V A ++ KV A D D GQNA L+Y +
Sbjct: 551 VLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLK 610
Query: 1087 SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+ F + G + L K+ L V+ +DNG
Sbjct: 611 ATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNG 650
Score = 50.8 bits (116), Expect = 4e-05
Identities = 41/138 (29%), Positives = 64/138 (46%), Gaps = 9/138 (6%)
Query: 772 QVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG 831
Q+ + + D ND+ P+F I ENS +G +++ A D D G NA+ YT+
Sbjct: 120 QIELQVRDINDHSPIFSEKQMLLEIPENSPVGAVFLLES---AKDLDVGINAVKSYTISP 176
Query: 832 EGK---EMFDVDENTGVVKFIGD-SLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGD 885
+M + +N + + D +LD E+ L A D G S A + +++ D
Sbjct: 177 NSHFHIKMRVIPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVVVVD 236
Query: 886 ENDNKPEFNQIEENSKVR 903
NDN PEF Q K+R
Sbjct: 237 INDNSPEFEQAFYEVKIR 254
Score = 47.6 bits (108), Expect = 3e-04
Identities = 57/252 (22%), Positives = 98/252 (38%), Gaps = 16/252 (6%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIAN- 722
V VVD+ND + + ++ENS ++ I + + G + + ++
Sbjct: 232 VVVVDINDNSPEFEQAFYE---VKIRENSILGSL--ILIVSAWDLDSGTNGEICYTFSHA 286
Query: 723 QQDVTDDIAIAE-DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
+D+ I + G I + PLD E + Y + + A G+ G V I++ D N
Sbjct: 287 SEDIRKTFEINQKSGEITLRAPLDFETIESYSIIIQATDGGGLF---GKSTVIIHVIDVN 343
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDE 841
DN P ++ I EN T + + D D G N + ++ + +
Sbjct: 344 DNAPEITVSSITSPIPEN----TPETVVMVFSIQDIDSGDNGRIVCSIPEDLPFVLKSSV 399
Query: 842 NTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
LDRE Y +++ D G L +E +++ D NDN P F Q
Sbjct: 400 ENYHTLETERPLDRESTAEYNITITVTDLGIPRLKTEHNTTVLVSDVNDNAPTFTQTSYT 459
Query: 900 SKVRIHRETKLN 911
VR + L+
Sbjct: 460 LFVRENNSPALH 471
Score = 46.8 bits (106), Expect = 6e-04
Identities = 67/317 (21%), Positives = 122/317 (38%), Gaps = 26/317 (8%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP---IGPSLTIPLTV-P 135
+L + + + D+ND+ PIF + + + E +P G F+ A +G + T+ P
Sbjct: 118 FLQIELQVRDINDHSPIFSEKQMLLEIPENSPVGA-VFLLESAKDLDVGINAVKSYTISP 176
Query: 136 RG-----LTIFKDIRAFDR---DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKV 187
+ + D R + DK S + DG S V ++ V
Sbjct: 177 NSHFHIKMRVIPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVV--V 234
Query: 188 LDYDAGDKEFQLVIMASGKRIHKEI-LFPEPIHAIDQDLGVGATLRYELISGND--RKLF 244
+D + EF+ R + + + A D D G + Y ++ RK F
Sbjct: 235 VDINDNSPEFEQAFYEVKIRENSILGSLILIVSAWDLDSGTNGEICYTFSHASEDIRKTF 294
Query: 245 SLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLP 304
++ +G + L LD + ++ + +QA+ ++ V I ++D+NDN P
Sbjct: 295 EINQKSGEITLRAPLDFET-----IESYSIIIQATDGGGLF--GKSTVIIHVIDVNDNAP 347
Query: 305 EFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVR 364
E V I EN P V+ D D G+NG + + + T+
Sbjct: 348 EITVSSITSPIPENTPETV-VMVFSIQDIDSGDNGRIVCSIPEDLPFVLKSSVENYHTLE 406
Query: 365 NQTVLDREAHSSLRMKV 381
+ LDRE+ + + +
Sbjct: 407 TERPLDRESTAEYNITI 423
Score = 44.0 bits (99), Expect = 0.004
Identities = 37/123 (30%), Positives = 56/123 (45%), Gaps = 5/123 (4%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
++S + ++ LD G L L + LD + E VL +Q + NP + Q +E+
Sbjct: 68 VVSNDKKQRLQLDINTGDLLLSETLDRE-ELCGSIEPCVLHLQVL-MQNPTQFLQ--IEL 123
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
++ D+ND+ P F + I EN P G L A D D G N +Y + P F I
Sbjct: 124 QVRDINDHSPIFSEKQMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTI-SPNSHFHI 182
Query: 355 DPR 357
R
Sbjct: 183 KMR 185
Score = 39.9 bits (89), Expect = 0.069
Identities = 38/126 (30%), Positives = 54/126 (42%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 543 LSSEALVRVLVLDANDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 601
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + + + N T + S +H L V D P +L
Sbjct: 602 AWLSYQLLKATEPGLFGVWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 660
Query: 553 AVVTIE 558
V+ ++
Sbjct: 661 QVLLVD 666
>AB026893-1|BAA95162.1| 1184|Homo sapiens vascular cadherin-2
protein.
Length = 1184
Score = 103 bits (247), Expect = 5e-21
Identities = 127/545 (23%), Positives = 225/545 (41%), Gaps = 32/545 (5%)
Query: 440 MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
++ ++VE+ +LD ND+ P F P E + +A + T I +A+DPD G N + Y L
Sbjct: 116 LALIHVEIQVLDINDHQPRF-PKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTL 174
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILEGRHALF--VEASDQPANPSERRYSLAVVTI 557
+ + + + + + H+ F V + NP + SL V +
Sbjct: 175 SPSEHFALDVIVGPDETKHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNV 234
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGYE 615
+ + P F + + + GT + ++ D + +V + L
Sbjct: 235 ------LDSNDNSPAFAESSLALEIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMP 288
Query: 616 EGV--PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDE 672
V F+++ ++G + + L P Y+ + A N + + V+DVND
Sbjct: 289 PEVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQARDLGPNPIPAHCKVLIKVLDVNDN 348
Query: 673 -RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
+ + A P + + + I + ++ S + NG + +L
Sbjct: 349 IPSIHVTWASQPSLVS-EALPKDSFIALVMADDLDSGH-NGLVHC-WLSQELGHFRLKRT 405
Query: 732 IAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
+ T LDRE+ Y +T++A+ ++G+ + Q++I I D NDN PVFE +
Sbjct: 406 NGNTYMLLTNATLDREQWPKYTLTLLAQ-DQGLQPLSAKKQLSIQISDINDNAPVFEKSR 464
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG-KEMFDVDENTGVVKFIG 850
YE EN+ + IKA DAD G N Y + + +D NTG V
Sbjct: 465 YEVSTRENNLPSLHL---ITIKAHDADLGINGKVSYRIQDSPVAHLVAIDSNTGEVT-AQ 520
Query: 851 DSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ-IEENSKVRIHRE 907
SL+ E+ ++ ++A D+G L+S + + + D NDN PE Q + + K +
Sbjct: 521 RSLNYEEMAGFEFQVIAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASL--S 578
Query: 908 TKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIR 967
+N + G ++ ++ N PL + TTI+ A D DSG NG+
Sbjct: 579 VLVNASTGHLLVPIETPNGLGPAGTDTPPLATHSSRPFLLTTIV---ARDADSGANGEPL 635
Query: 968 YEFNS 972
Y S
Sbjct: 636 YSIRS 640
Score = 89.8 bits (213), Expect = 6e-17
Identities = 117/426 (27%), Positives = 179/426 (42%), Gaps = 53/426 (12%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
+E+G + T + LDRE+ + F+ + V I + D ND+ P F
Sbjct: 81 SEEGLLSTGRRLDREQLCRQWDPCLVSFDVLATGDLALIHVEIQVLDINDHQPRFPKGEQ 140
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDS 852
E I E++ + T I +D +A D D G N L YTL E F +D G
Sbjct: 141 ELEISESASLRTRIPLD---RALDPDTGPNTLHTYTL--SPSEHFALDVIVGP------- 188
Query: 853 LDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNG 912
D K +L +V + S +L++ D N N P+ S V+++ +
Sbjct: 189 -DETKHA--ELIVVKELDREIHSFFDLVLTAYD-NGNPPKSG----TSLVKVNVLDSNDN 240
Query: 913 TAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNS 972
+ F ++ AL++ E+ GT +IKL A D D G NG++ EF
Sbjct: 241 SPAFA------ESSLALEIQ---------EDAAPGTLLIKLTATDPDQGPNGEV--EFFL 283
Query: 973 EVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALD-GGN-LNDN 1028
++PP EV F I+ + G VI+ R L E + +++ A D G N + +
Sbjct: 284 SKHMPP--------EVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQARDLGPNPIPAH 335
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYN--FNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQP 1086
V + V DVND+ P TW + V EA + V A D D G N + ++
Sbjct: 336 CKVLIKVLDVNDNIPSIHVTWASQPSLVSEALPKDSFIALVMADDLDSGHNGLVHCWLSQ 395
Query: 1087 SDTDLPFE-ISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ + T +L N LDRE KY LT++A+D G D+N
Sbjct: 396 ELGHFRLKRTNGNTYMLLTNATLDREQWPKYTLTLLAQDQG-LQPLSAKKQLSIQISDIN 454
Query: 1146 DNSPKF 1151
DN+P F
Sbjct: 455 DNAPVF 460
Score = 72.9 bits (171), Expect = 8e-12
Identities = 124/506 (24%), Positives = 205/506 (40%), Gaps = 66/506 (13%)
Query: 997 RHGHVIVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+H +IV + L E S F L ++A D GN + V+V V D ND+ P F ++
Sbjct: 192 KHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLAL 251
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTDLPFEISPLTGVLSVNGELD 1109
++E +L K+ ATD D G N + +F+ P + F I TG + + LD
Sbjct: 252 EIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQVILRRPLD 311
Query: 1110 RETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEW-KHPE--AD 1166
E Y + V ARD G DVNDN P + + W P ++
Sbjct: 312 YEKNPAYEVDVQARDLG-PNPIPAHCKVLIKVLDVNDNIPSIH-----VTWASQPSLVSE 365
Query: 1167 ELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNG-LILYSLPQRKNQ- 1224
L +F +++M + N + +++ + NGN ++L + + Q
Sbjct: 366 ALPKDSFIALVMADDLDS--GHNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDREQW 423
Query: 1225 ---------QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVE 1275
Q+ GL LS+ L + ++D+ D + PVF YE+ EN +
Sbjct: 424 PKYTLTLLAQDQGLQPLSAKKQLSIQISDIND-----NAPVFEKSRYEVSTRENNLPSLH 478
Query: 1276 LVSLNL--TEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIV 1333
L+++ + N K+ Y I D+ + ID G + RS + E +E V
Sbjct: 479 LITIKAHDADLGINGKVSYRI---QDSPVAHLVAIDSNTGEVTAQRSLNYEEMAGFEFQV 535
Query: 1334 RAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTN---GNRPLVTA 1390
+AED + M V V V + D NDN+P+ + +
Sbjct: 536 -----------------IAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASLS 578
Query: 1391 IPTTAPFGYQVMQLKGAIGHHPTASRTVRADTDELVFFERLSLNGLTSPQATDSDIGINA 1450
+ A G+ ++ ++ G P + T T R L LT+ A D+D G N
Sbjct: 579 VLVNASTGHLLVPIETPNGLGPAGTDTPPLATHS----SRPFL--LTTIVARDADSGANG 632
Query: 1451 DIRYQILN-EQAPRFAIDPVSGTVRV 1475
+ Y I + +A F ++P +G + V
Sbjct: 633 EPLYSIRSGNEAHLFILNPHTGQLFV 658
Score = 64.9 bits (151), Expect = 2e-09
Identities = 129/540 (23%), Positives = 213/540 (39%), Gaps = 49/540 (9%)
Query: 31 HVSVILAQSIDSLVDSDSPQNVVKFRLGCDFDEGDDLVRIGA--GLNQISAYLSVTVYIE 88
H +I+ + +D + S + + G G LV++ + A+ ++ +E
Sbjct: 193 HAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALE 252
Query: 89 DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSL--TIPLTVPRGLTIFKDIRA 146
D P L T + P GE F FL + P + T + G I + R
Sbjct: 253 IQEDAAPGTLLIKLTATDPDQGPNGEVEF-FLSKHMPPEVLDTFSIDAKTGQVILR--RP 309
Query: 147 FDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGK 206
D +K P +V V D G + + H VL+ KVLD + V AS
Sbjct: 310 LDYEK--NPAYEVD---VQARDLGPNPIPA-HCKVLI--KVLDVNDNIPSIH-VTWASQP 360
Query: 207 RIHKEILFPEPIHAI--DQDLGVGATLRYELISGNDRKLFSLDSVNGSLF-LEKELDLDA 263
+ E L + A+ DL G + F L NG+ + L LD
Sbjct: 361 SLVSEALPKDSFIALVMADDLDSGHNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDR 420
Query: 264 EHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGF 323
E T L Q L PL +A+ ++ I++ D+NDN P FE Y +S EN
Sbjct: 421 EQ-WPKYTLTLLAQDQGLQ-PL-SAKKQLSIQISDINDNAPVFEKSRYEVSTRENNLPSL 477
Query: 324 SVLQVMATDKDQGENGEFTYQLDDPKGA--FSIDPRSGWLTVRNQTVLDREAHSSLRMKV 381
++ + A D D G NG+ +Y++ D A +ID +G +T Q L+ E + +V
Sbjct: 478 HLITIKAHDADLGINGKVSYRIQDSPVAHLVAIDSNTGEVTA--QRSLNYEEMAGFEFQV 535
Query: 382 YAKETNPSVVGTFADSQRIAKW-RRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLM 440
A+++ ++ + ++ W NAP E V D + + + L+
Sbjct: 536 IAEDSGQPML-----ASSVSVWVSLLDANDNAP-EVVQPVLSDGKASLSVLVNASTGHLL 589
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
+ L A + P + F + T++ + D D G NG LY ++
Sbjct: 590 VPIETPNGLGPAGTDTPPLATHSSRPFLLT------TIVAR----DADSGANGEPLYSIR 639
Query: 501 RTSNLTITSPFKINPNTGT--VSVAESPILEGRH-ALFVEASDQPANPSERRYSLAVVTI 557
+ + F +NP+TG V+V + L G L + DQ + P + R L V+ +
Sbjct: 640 SGNEAHL---FILNPHTGQLFVNVTNASSLIGSEWELEIVVEDQGSPPLQTRALLRVMFV 696
Score = 62.1 bits (144), Expect = 1e-08
Identities = 76/337 (22%), Positives = 145/337 (43%), Gaps = 37/337 (10%)
Query: 579 EFWVGSNVGIGTSVGQIRVNDAFE----QNDVSYDLLHGYEEGVPFAVEERSGVITVVDD 634
++ V V GT +G++ E Q ++ +L + +P V+ G+++
Sbjct: 33 KYQVSEEVPSGTVIGKLSQELGREERRRQAGAAFQVLQ-LPQALPIQVDSEEGLLSTGRR 91
Query: 635 LSR------YNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHV 688
L R ++ + F+ +A +L+++ + + V+D+ND + KG
Sbjct: 92 LDREQLCRQWDPCLVSFDVLA---TGDLALI-HVEIQVLDINDHQPRFPKGEQE------ 141
Query: 689 KENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLIANQQDVTDDIAIAEDGT----IFTQKP 743
E S A++ + + G + + ++ + D+ + D T + K
Sbjct: 142 LEISESASLRTRIPLDRALDPDTGPNTLHTYTLSPSEHFALDVIVGPDETKHAELIVVKE 201
Query: 744 LDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIG 803
LDRE + + V+ ++ G +G V + + D NDN P F ++ I E++ G
Sbjct: 202 LDREIHSFFDL-VLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALEIQEDAAPG 260
Query: 804 TEIKMDNIIKATDADEGTNALFMYTLF----GEGKEMFDVDENTGVVKFIGDSLDREKKI 859
T + + ATD D+G N + L E + F +D TG V + LD EK
Sbjct: 261 TLLIK---LTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQV-ILRRPLDYEKNP 316
Query: 860 MYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFN 894
Y++ + ARD G + + +++I + D NDN P +
Sbjct: 317 AYEVDVQARDLGPNPIPAHCKVLIKVLDVNDNIPSIH 353
Score = 40.3 bits (90), Expect = 0.052
Identities = 35/112 (31%), Positives = 50/112 (44%), Gaps = 7/112 (6%)
Query: 288 AQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD 347
A VEI++LD+ND+ P F + I E+ + A D D G N TY L
Sbjct: 117 ALIHVEIQVLDINDHQPRFPKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTL-S 175
Query: 348 PKGAFSIDPRSGWLTVRNQTV-----LDREAHSSLRMKVYAKET-NPSVVGT 393
P F++D G ++ + LDRE HS + + A + NP GT
Sbjct: 176 PSEHFALDVIVGPDETKHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGT 227
>BC113611-1|AAI13612.1| 797|Homo sapiens protocadherin beta 11
protein.
Length = 797
Score = 103 bits (246), Expect = 7e-21
Identities = 129/528 (24%), Positives = 219/528 (41%), Gaps = 59/528 (11%)
Query: 904 IHRETKLNGTAGFTIIEVKPK--NKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSG 961
+H + + F IE++ + N + + L IPEN P+G + +A DLD G
Sbjct: 104 LHLQVLMQNPTQFLQIELQVRDINDHSPIFSEKQMLLEIPENSPVGAVFLLESAKDLDVG 163
Query: 962 LNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISA 1019
+N Y + P S R N ++ +++ ++L E E +SA
Sbjct: 164 INAVKSYTIS-----PNSHFHIKM----RVIPDNRKYPELVLDKALDYEELPELSFILSA 214
Query: 1020 LDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQN 1077
LDGG+ + VRV V D+ND+ P F++ +Y + E ++ V A D D G N
Sbjct: 215 LDGGSPPRSGTALVRVVVVDINDNSPEFEQAFYEVKIRENSILGSLILIVSAWDLDSGTN 274
Query: 1078 ANLTYFIQPSDTDL--PFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXX 1135
+ Y + D+ FEI+ +G +++ LD ET + Y + + A D G
Sbjct: 275 GEICYTFSHASEDIRKTFEINQKSGEITLRAPLDFETIESYSIIIQATDGG---GLFGKS 331
Query: 1136 XXXXXXXDVNDNSPKF--YAFDELLEWKHPEADEL--SNHNFESVMMIPVYKATIEENAP 1191
DVNDN+P+ + + PE + S + +S + +I E+ P
Sbjct: 332 TVIIHVIDVNDNAPEITVSSITSPIPENTPETVVMVFSIQDIDSGDNGRIV-CSIPEDLP 390
Query: 1192 --IGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEV 1249
+ ++V + +T+ + Y++ +LG+P L + V V+DV D
Sbjct: 391 FVLKSSVENYYTLETERPLDRESTAEYNI--TITVTDLGIPRLKTEHNTTVLVSDVND-- 446
Query: 1250 EMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV 1307
+ P F Y L + EN + + + S++ T+ N ++ Y +L D + +
Sbjct: 447 ---NAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVNYSLLPPQDLHLPLASL 503
Query: 1308 --IDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVK 1365
I+ NG L+ +RS D E ++ V A R P + +
Sbjct: 504 VSINTDNGHLFALRSLDYEALQAFDFRVGAT----DRGSPAL-------------SSEAL 546
Query: 1366 VVVRIKDVNDNSP----KFTNGNRPLVTAIPTTAPFGYQVMQLKGAIG 1409
V V + D NDNSP NG+ P +P A GY V ++ G
Sbjct: 547 VRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDG 594
Score = 103 bits (246), Expect = 7e-21
Identities = 111/465 (23%), Positives = 190/465 (40%), Gaps = 36/465 (7%)
Query: 442 FVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQR 501
F+ +E+ + D ND++P+F + + N+ VG V A D D+G N + Y +
Sbjct: 116 FLQIELQVRDINDHSPIFSEKQML-LEIPENSPVGAVFLLESAKDLDVGINAVKSYTISP 174
Query: 502 TSNLTITSPFKINPNTGTVSVAESPILEGRH----ALFVEASDQPANPSERRYSLAVVTI 557
S+ I I N + L+ + + A D + P + VV +
Sbjct: 175 NSHFHIKMRV-IPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVVVV 233
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYE 615
++ + P+F A YE + N +G+ + + D+ ++ Y H E
Sbjct: 234 DINDNS-------PEFEQAFYEVKIRENSILGSLILIVSAWDLDSGTNGEICYTFSHASE 286
Query: 616 E-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERG 674
+ F + ++SG IT+ L Y + + L + +HV+DVND
Sbjct: 287 DIRKTFEINQKSGEITLRAPLDFETIESYSI-IIQATDGGGLFGKSTVIIHVIDVNDNAP 345
Query: 675 VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAE 734
+ S I + EN+ + +F ++ I G + I ++
Sbjct: 346 EI---TVSSITSPIPENTPETVV-MVF--SIQDIDSGDNGRIVCSIPEDLPFVLKSSVEN 399
Query: 735 DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEG 794
T+ T++PLDRE Y +T+ + G+ + T+ + D NDN P F +Y
Sbjct: 400 YYTLETERPLDRESTAEYNITITVT-DLGIPRLKTEHNTTVLVSDVNDNAPTFTQTSYTL 458
Query: 795 FIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDENTGVVKF 848
F+ EN+ I + ATD D GTNA Y+L + ++ + G + F
Sbjct: 459 FVRENNSPALHI---GSVSATDRDSGTNAQVNYSLLPPQDLHLPLASLVSINTDNGHL-F 514
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
SLD E + + A D G LSSEA + +++ D NDN P
Sbjct: 515 ALRSLDYEALQAFDFRVGATDRGSPALSSEALVRVLVLDANDNSP 559
Score = 75.4 bits (177), Expect = 1e-12
Identities = 85/325 (26%), Positives = 140/325 (43%), Gaps = 31/325 (9%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPI--GPSLTIPLTVPRGLT 139
+V +++ DVNDN P + + E TP +F I I G + I ++P L
Sbjct: 332 TVIIHVIDVNDNAPEITVSSITSPIPENTPE-TVVMVFSIQDIDSGDNGRIVCSIPEDLP 390
Query: 140 IF-----KDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
++ + ++P S Y+I ++ D G L++ H +L+ V D
Sbjct: 391 FVLKSSVENYYTLETERPLDRESTAEYNITITVTDLGIPRLKTEHNTTVLVSDVNDNAPT 450
Query: 194 DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLFSLDS 248
+ + + + L + A D+D G A + Y L+ D L S+++
Sbjct: 451 FTQTSYTLFV--RENNSPALHIGSVSATDRDSGTNAQVNYSLLPPQDLHLPLASLVSINT 508
Query: 249 VNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEV 308
NG LF + LD +A LQA F +V A+ +P +++A V + +LD NDN P
Sbjct: 509 DNGHLFALRSLDYEA---LQA--FDFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLY 563
Query: 309 DFYNISI--VENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGW 360
N S E +P G+ V +V+A D D G+N +YQL G F + +G
Sbjct: 564 PLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG- 622
Query: 361 LTVRNQTVLDREAHSSLRMKVYAKE 385
VR +L + R+ V K+
Sbjct: 623 -EVRTARLLSERDAAKHRLVVLVKD 646
Score = 74.9 bits (176), Expect = 2e-12
Identities = 62/236 (26%), Positives = 111/236 (47%), Gaps = 17/236 (7%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLIAN 722
+ V D+ND + + ++ + ENS +G +F + G V+ + I+
Sbjct: 121 LQVRDINDHSPIF---SEKQMLLEIPENSP---VGAVFLLESAKDLDVGINAVKSYTISP 174
Query: 723 QQDVTDDIAIAEDGTIFTQKPLDR--EKRDVYRMT-VIAEFNKGVISGAGIYQVTIYIED 779
+ + D + + LD+ + ++ ++ +++ + G +G V + + D
Sbjct: 175 NSHFHIKMRVIPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVVVVD 234
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM--- 836
NDN P FE A YE I ENS +G+ I I+ A D D GTN YT +++
Sbjct: 235 INDNSPEFEQAFYEVKIRENSILGSLIL---IVSAWDLDSGTNGEICYTFSHASEDIRKT 291
Query: 837 FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
F++++ +G + + LD E Y + + A D GGL ++ +II + D NDN PE
Sbjct: 292 FEINQKSGEIT-LRAPLDFETIESYSIIIQATDGGGLFGKSTVIIHVIDVNDNAPE 346
Score = 68.1 bits (159), Expect = 2e-10
Identities = 57/175 (32%), Positives = 86/175 (49%), Gaps = 17/175 (9%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGS-----LFLEKELDLDAEHNLQANTFVL 274
A D D+G+ A Y IS N + + + L L+K LD + L +F+L
Sbjct: 157 AKDLDVGINAVKSYT-ISPNSHFHIKMRVIPDNRKYPELVLDKALDYE---ELPELSFIL 212
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
A +P ++ A V + ++D+NDN PEFE FY + I EN G +L V A D D
Sbjct: 213 S--ALDGGSPPRSGTALVRVVVVDINDNSPEFEQAFYEVKIRENSILGSLILIVSAWDLD 270
Query: 335 QGENGE----FTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
G NGE F++ +D + F I+ +SG +T+R LD E S + + A +
Sbjct: 271 SGTNGEICYTFSHASEDIRKTFEINQKSGEITLR--APLDFETIESYSIIIQATD 323
Score = 62.1 bits (144), Expect = 1e-08
Identities = 64/220 (29%), Positives = 89/220 (40%), Gaps = 18/220 (8%)
Query: 917 TIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYI 976
T + V N A Q + EN I ++A D DSG N Q+ Y +
Sbjct: 437 TTVLVSDVNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVNYSL-----L 491
Query: 977 PPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVR 1032
PP L L + IN +GH+ RSL E+ F + A D G+ L+ VR
Sbjct: 492 PPQDLH---LPLASLVSINTDNGHLFALRSLDYEALQAFDFRVGATDRGSPALSSEALVR 548
Query: 1033 VFVKDVNDHFPVFKKTWYNFN------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQP 1086
V V D ND+ P N + V A ++ KV A D D GQNA L+Y +
Sbjct: 549 VLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLK 608
Query: 1087 SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+ F + G + L K+ L V+ +DNG
Sbjct: 609 ATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNG 648
Score = 50.8 bits (116), Expect = 4e-05
Identities = 41/138 (29%), Positives = 64/138 (46%), Gaps = 9/138 (6%)
Query: 772 QVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG 831
Q+ + + D ND+ P+F I ENS +G +++ A D D G NA+ YT+
Sbjct: 118 QIELQVRDINDHSPIFSEKQMLLEIPENSPVGAVFLLES---AKDLDVGINAVKSYTISP 174
Query: 832 EGK---EMFDVDENTGVVKFIGD-SLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGD 885
+M + +N + + D +LD E+ L A D G S A + +++ D
Sbjct: 175 NSHFHIKMRVIPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVVVVD 234
Query: 886 ENDNKPEFNQIEENSKVR 903
NDN PEF Q K+R
Sbjct: 235 INDNSPEFEQAFYEVKIR 252
Score = 48.4 bits (110), Expect = 2e-04
Identities = 57/252 (22%), Positives = 98/252 (38%), Gaps = 16/252 (6%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIAN- 722
V VVD+ND + + ++ENS ++ I + + G + + ++
Sbjct: 230 VVVVDINDNSPEFEQAFYE---VKIRENSILGSL--ILIVSAWDLDSGTNGEICYTFSHA 284
Query: 723 QQDVTDDIAIAE-DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
+D+ I + G I + PLD E + Y + + A G+ G V I++ D N
Sbjct: 285 SEDIRKTFEINQKSGEITLRAPLDFETIESYSIIIQATDGGGLF---GKSTVIIHVIDVN 341
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDE 841
DN P ++ I EN T + + D D G N + ++ + +
Sbjct: 342 DNAPEITVSSITSPIPEN----TPETVVMVFSIQDIDSGDNGRIVCSIPEDLPFVLKSSV 397
Query: 842 NTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
LDRE Y +++ D G L +E +++ D NDN P F Q
Sbjct: 398 ENYYTLETERPLDRESTAEYNITITVTDLGIPRLKTEHNTTVLVSDVNDNAPTFTQTSYT 457
Query: 900 SKVRIHRETKLN 911
VR + L+
Sbjct: 458 LFVRENNSPALH 469
Score = 47.6 bits (108), Expect = 3e-04
Identities = 67/317 (21%), Positives = 122/317 (38%), Gaps = 26/317 (8%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP---IGPSLTIPLTV-P 135
+L + + + D+ND+ PIF + + + E +P G F+ A +G + T+ P
Sbjct: 116 FLQIELQVRDINDHSPIFSEKQMLLEIPENSPVGA-VFLLESAKDLDVGINAVKSYTISP 174
Query: 136 RG-----LTIFKDIRAFDR---DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKV 187
+ + D R + DK S + DG S V ++ V
Sbjct: 175 NSHFHIKMRVIPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVV--V 232
Query: 188 LDYDAGDKEFQLVIMASGKRIHKEI-LFPEPIHAIDQDLGVGATLRYELISGND--RKLF 244
+D + EF+ R + + + A D D G + Y ++ RK F
Sbjct: 233 VDINDNSPEFEQAFYEVKIRENSILGSLILIVSAWDLDSGTNGEICYTFSHASEDIRKTF 292
Query: 245 SLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLP 304
++ +G + L LD + ++ + +QA+ ++ V I ++D+NDN P
Sbjct: 293 EINQKSGEITLRAPLDFET-----IESYSIIIQATDGGGLF--GKSTVIIHVIDVNDNAP 345
Query: 305 EFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVR 364
E V I EN P V+ D D G+NG + + + T+
Sbjct: 346 EITVSSITSPIPENTPETV-VMVFSIQDIDSGDNGRIVCSIPEDLPFVLKSSVENYYTLE 404
Query: 365 NQTVLDREAHSSLRMKV 381
+ LDRE+ + + +
Sbjct: 405 TERPLDRESTAEYNITI 421
Score = 44.0 bits (99), Expect = 0.004
Identities = 37/123 (30%), Positives = 56/123 (45%), Gaps = 5/123 (4%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
++S + ++ LD G L L + LD + E VL +Q + NP + Q +E+
Sbjct: 66 VVSNDKKQRLQLDINTGDLLLSETLDRE-ELCGSIEPCVLHLQVL-MQNPTQFLQ--IEL 121
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
++ D+ND+ P F + I EN P G L A D D G N +Y + P F I
Sbjct: 122 QVRDINDHSPIFSEKQMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTI-SPNSHFHI 180
Query: 355 DPR 357
R
Sbjct: 181 KMR 183
Score = 39.9 bits (89), Expect = 0.069
Identities = 38/126 (30%), Positives = 54/126 (42%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 541 LSSEALVRVLVLDANDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 599
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + + + N T + S +H L V D P +L
Sbjct: 600 AWLSYQLLKATEPGLFGVWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 658
Query: 553 AVVTIE 558
V+ ++
Sbjct: 659 QVLLVD 664
>BC113609-1|AAI13610.1| 798|Homo sapiens protocadherin alpha 4
protein.
Length = 798
Score = 103 bits (246), Expect = 7e-21
Identities = 115/427 (26%), Positives = 183/427 (42%), Gaps = 60/427 (14%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAG--IYQVTIYIEDENDNPPVFEHAT 791
++G +F +DRE ++ R + + VI ++ V + + D NDNPPVF
Sbjct: 80 QNGILFVNSRIDRE--ELCRRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPVFPATQ 137
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD 851
I E+ + + ++ A+DAD G NAL Y L E F +++
Sbjct: 138 KNLSIAESRPLDSRFPLEG---ASDADIGENALLTYRL--SPNEYFSLEKPP-------- 184
Query: 852 SLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
+ +++ L L+ R + E+ +++ + KPE L
Sbjct: 185 ----DDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPE-----------------LT 223
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
GT +I V N A D+ + EN+P GT +IKLNA DLD GLNG I Y F+
Sbjct: 224 GTVQL-LITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFS 282
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN--LND 1027
++ I P+ VK F I+ G +IV + E + + + +D G L+
Sbjct: 283 ND--ISPN--------VKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSG 332
Query: 1028 NISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
+ V V V+D ND+ P + + + E V+ + +D D G N +T +
Sbjct: 333 HCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSL--- 389
Query: 1088 DTDLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDV 1144
+ +PF+ +S S ++ LDRE+ Y L V ARD G DV
Sbjct: 390 TSHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGG-SPSLWATASVSVEVADV 448
Query: 1145 NDNSPKF 1151
NDN+P F
Sbjct: 449 NDNAPAF 455
Score = 88.6 bits (210), Expect = 1e-16
Identities = 111/464 (23%), Positives = 197/464 (42%), Gaps = 35/464 (7%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + +T+LDANDN P F +Y+ + N GT++ K+ A D D G NG ++Y
Sbjct: 221 ELTGTVQLLITVLDANDNAPAF-DRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVY 279
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + S F I+P TG + V E + + VE D+ P V
Sbjct: 280 SFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGH---CRV 336
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+EV + N ++PD + + +GT + I V+D + V+ +
Sbjct: 337 IVEV----EDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSD--KDMGVNGLVTCSLT 390
Query: 616 EGVPF-AVEERSGVITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVND 671
VPF V ++V D L R + Y+ A + +L + +V V DVND
Sbjct: 391 SHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVND 450
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLI----ANQQDVT 727
+ ++ +F VKEN+ IF + V + + ++ ++
Sbjct: 451 NAPAFAQPEYT--VF-VKENNPPGC--HIFTVSAWDADAQENALVSYSLVERRVGERALS 505
Query: 728 DDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
+++ AE G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 506 SYVSVHAESGKVYALQPLDHEELELLQFQVTAR-DAGVPPLGSNVTLQVFVLDENDNAPA 564
Query: 787 FEHATYEGFIMENSK-IGTEIKMDNI---IKATDADEGTNALFMYTL---FGEGKEMFDV 839
G S+ + + + ++ ++A DAD G NA Y L G + F V
Sbjct: 565 LLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRV 624
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMI 883
TG + +LD ++L ++ +D G + A +++
Sbjct: 625 GLYTGEIS-TTRALDETDAPRHRLLVLVKDHGEPALTATATVLV 667
Score = 74.1 bits (174), Expect = 3e-12
Identities = 104/475 (21%), Positives = 180/475 (37%), Gaps = 30/475 (6%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +V+V + D NDN PVF P+ S+ + + + A D D+G
Sbjct: 105 HLEVIVDRPLQVFHVDVEVRDINDNPPVF-PATQKNLSIAESRPLDSRFPLEGASDADIG 163
Query: 491 QNGMVLYDLQRTSNLTITSP--FKINPNTGTVSVAESPILEGRHALFVEASDQPANPSER 548
+N ++ Y L ++ P ++ G + E V + P
Sbjct: 164 ENALLTYRLSPNEYFSLEKPPDDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPE-- 221
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDV 606
T+++ + P F Y+ + NV GT V ++ +D E D+
Sbjct: 222 ----LTGTVQLLITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDI 277
Query: 607 SYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
Y + V F ++ +G I V + Y+ + + L + + V
Sbjct: 278 VYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGI-DKGQLPLSGHCRV 336
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
+V+V D + + ++E++ + + + + NG V + +
Sbjct: 337 -IVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGL--VTCSLTSHV 393
Query: 725 DVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
++ LDRE Y + V A + G S V++ + D NDN
Sbjct: 394 PFKLVSTFKNYYSLVLDSALDRESVSAYELVVTAR-DGGSPSLWATASVSVEVADVNDNA 452
Query: 785 PVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF----GEG--KEMFD 838
P F Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 453 PAFAQPEYTVFVKENNPPGCHIFT---VSAWDADAQENALVSYSLVERRVGERALSSYVS 509
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 510 VHAESGKVYAL-QPLDHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAP 563
Score = 72.9 bits (171), Expect = 8e-12
Identities = 52/157 (33%), Positives = 78/157 (49%), Gaps = 20/157 (12%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDS------VNG-SLFLEKELDLDAEHNLQANTF 272
A D D+G A L Y L + + FSL+ V G L L K LD + +A
Sbjct: 157 ASDADIGENALLTYRL---SPNEYFSLEKPPDDELVKGLGLILRKSLDRE-----EAPEI 208
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
L + A+ P T ++ I +LD NDN P F+ Y + ++EN+PNG V+++ A+D
Sbjct: 209 FLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASD 268
Query: 333 KDQGENGEFTYQLDDP-----KGAFSIDPRSGWLTVR 364
D+G NG+ Y + K F IDP +G + V+
Sbjct: 269 LDEGLNGDIVYSFSNDISPNVKSKFHIDPITGQIIVK 305
Score = 67.3 bits (157), Expect = 4e-10
Identities = 73/290 (25%), Positives = 115/290 (39%), Gaps = 18/290 (6%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L G +++ + + + + D NDN P F T Y V + E P G + +
Sbjct: 212 LTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDE 271
Query: 127 SLTIPLTVPRGLTIFKDIRAFDRDKPNT-----------PNSDVHYSIVSGNDDGHFALE 175
L + I ++++ P T S + IV G D G L
Sbjct: 272 GLNGDIVYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPL- 330
Query: 176 SSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
S H V++ + + + D EF+ + + + + I D+D+GV + L
Sbjct: 331 SGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIAL-ISVSDKDMGVNGLVTCSL 389
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIE 295
S KL S SL L+ LD ++ + + L V A +P A A V +E
Sbjct: 390 TSHVPFKLVSTFKNYYSLVLDSALDRES-----VSAYELVVTARDGGSPSLWATASVSVE 444
Query: 296 LLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+ D+NDN P F Y + + EN P G + V A D D EN +Y L
Sbjct: 445 VADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSL 494
Score = 63.7 bits (148), Expect = 5e-09
Identities = 48/164 (29%), Positives = 75/164 (45%), Gaps = 6/164 (3%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I + +D E+ Y + ++ +KG + +G +V + +ED NDN P E +
Sbjct: 300 GQIIVKGYIDFEESKSYEI-IVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLP 358
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
I E++ +GT I + I +D D G N L +L + +LDR
Sbjct: 359 IREDAPLGTVIAL---ISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSALDR 415
Query: 856 EKKIMYKLSLVARDTGGLS--SEAELIIMIGDENDNKPEFNQIE 897
E Y+L + ARD G S + A + + + D NDN P F Q E
Sbjct: 416 ESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPE 459
Score = 63.3 bits (147), Expect = 6e-09
Identities = 50/172 (29%), Positives = 83/172 (48%), Gaps = 14/172 (8%)
Query: 728 DDIAIAEDGTIFTQKPLDREKR-DVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
DD + G I +K LDRE+ +++ + + K ++G Q+ I + D NDN P
Sbjct: 185 DDELVKGLGLIL-RKSLDREEAPEIFLVLTATDGGKPELTGT--VQLLITVLDANDNAPA 241
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGE----GKEMFDVDEN 842
F+ Y+ ++EN GT + N A+D DEG N +Y+ + K F +D
Sbjct: 242 FDRTIYKVRLLENVPNGTLVIKLN---ASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPI 298
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIGDENDNKPE 892
TG + + +D E+ Y++ + D G L S +I+ + D NDN P+
Sbjct: 299 TGQI-IVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPD 349
Score = 59.7 bits (138), Expect = 8e-08
Identities = 62/221 (28%), Positives = 94/221 (42%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y E +
Sbjct: 443 VEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSL-VERRVGE 501
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVF 1034
LS+ Y ++ G V + L E + ++A D G L N++++VF
Sbjct: 502 RALSS-------YVSVHAESGKVYALQPLDHEELELLQFQVTARDAGVPPLGSNVTLQVF 554
Query: 1035 VKDVNDHFPVF---KKTWYNFNVEE----AQYTRRVLGKVDATDADFGQNANLTYFIQP- 1086
V D ND+ P + V E + V+ KV A DAD G NA L+Y +QP
Sbjct: 555 VLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPG 614
Query: 1087 -SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+PF + TG +S LD ++ L V+ +D+G
Sbjct: 615 TGGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHG 655
Score = 59.3 bits (137), Expect = 1e-07
Identities = 70/245 (28%), Positives = 105/245 (42%), Gaps = 23/245 (9%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
I+EV+ N D++ I E+ P+GT I ++ D D G+NG + S V
Sbjct: 337 IVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHV--- 393
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRV 1033
P KL + K Y+ + ++ +L ES + L ++A DGG+ L SV V
Sbjct: 394 PFKLVST---FKNYYSL-------VLDSALDRESVSAYELVVTARDGGSPSLWATASVSV 443
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTD 1090
V DVND+ P F + Y V+E + V A DAD +NA ++Y + + +
Sbjct: 444 EVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERA 503
Query: 1091 LPFEIS--PLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
L +S +G + LD E + V ARD G D NDN+
Sbjct: 504 LSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDAG-VPPLGSNVTLQVFVLDENDNA 562
Query: 1149 PKFYA 1153
P A
Sbjct: 563 PALLA 567
Score = 47.6 bits (108), Expect = 3e-04
Identities = 52/186 (27%), Positives = 85/186 (45%), Gaps = 18/186 (9%)
Query: 175 ESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVG-ATL-- 231
+ S + +LLL + ++AG+ + + K H + I QDLG+ A L
Sbjct: 9 QESRRLLLLLLLLAAWEAGNGQLHYSVSEEAK--HGTF-----VGRIAQDLGLELAELVP 61
Query: 232 -RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQVQASQLNNPLKTAQ 289
+ + S L ++ NG LF+ +D + A + L+V ++ PL+
Sbjct: 62 RLFRVASKGRGGLLEVNLQNGILFVNSRIDREELCRRSAECSIHLEVI---VDRPLQVFH 118
Query: 290 ARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
V++E+ D+NDN P F N+SI E+ P A+D D GEN TY+L P
Sbjct: 119 --VDVEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRL-SPN 175
Query: 350 GAFSID 355
FS++
Sbjct: 176 EYFSLE 181
Score = 46.0 bits (104), Expect = 0.001
Identities = 32/108 (29%), Positives = 52/108 (48%), Gaps = 7/108 (6%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++TV D D + P F Y++ + ENV ++ LN ++ E
Sbjct: 218 GKPELTGTVQLLITVLDAND-----NAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIV 1333
N + Y N+ +++ F IDP G + + D E +YE+IV
Sbjct: 273 LNGDIVYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIV 320
Score = 43.6 bits (98), Expect = 0.006
Identities = 90/377 (23%), Positives = 147/377 (38%), Gaps = 36/377 (9%)
Query: 44 VDSDSPQNVVKFRLGCDFDEGDDLVRIGAGLNQ----ISAYLSVTVYIEDVNDNVPIFLD 99
+D + Q +VK + DF+E I G+++ +S + V V +ED NDNVP
Sbjct: 295 IDPITGQIIVKGYI--DFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEF 352
Query: 100 TPYHVTVDELTPTGEKAFIFLIAP----IGPSLTIPLT--VPRGL-TIFKDIRAFDRDKP 152
+ + E P G + ++ + +T LT VP L + FK+ + D
Sbjct: 353 KSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSA 412
Query: 153 NTPNSDVHYS-IVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKE 211
S Y +V+ D G +L ++ + + V D + + +
Sbjct: 413 LDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGC 472
Query: 212 ILFPEPIHAIDQDLGVGATLRYELISGN--DRKLFSLDSVN---GSLFLEKELDLDAEHN 266
+F + A D D A + Y L+ +R L S SV+ G ++ + LD +
Sbjct: 473 HIFT--VSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELEL 530
Query: 267 LQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLP--- 320
LQ QV A P + +++ +LD NDN P ++ E +P
Sbjct: 531 LQ-----FQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSV 585
Query: 321 -NGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLT--VRNQTVLDREAHSSL 377
G V +V A D D G N +Y+L G I R G T + LD
Sbjct: 586 GVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAPRH 645
Query: 378 RMKVYAKE-TNPSVVGT 393
R+ V K+ P++ T
Sbjct: 646 RLLVLVKDHGEPALTAT 662
>BC112132-1|AAI12133.1| 797|Homo sapiens protocadherin beta 11
protein.
Length = 797
Score = 103 bits (246), Expect = 7e-21
Identities = 129/528 (24%), Positives = 219/528 (41%), Gaps = 59/528 (11%)
Query: 904 IHRETKLNGTAGFTIIEVKPK--NKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSG 961
+H + + F IE++ + N + + L IPEN P+G + +A DLD G
Sbjct: 104 LHLQVLMQNPTQFLQIELQVRDINDHSPIFSEKQMLLEIPENSPVGAVFLLESAKDLDVG 163
Query: 962 LNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISA 1019
+N Y + P S R N ++ +++ ++L E E +SA
Sbjct: 164 INAVKSYTIS-----PNSHFHIKM----RVIPDNRKYPELVLDKALDYEELPELSFILSA 214
Query: 1020 LDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQN 1077
LDGG+ + VRV V D+ND+ P F++ +Y + E ++ V A D D G N
Sbjct: 215 LDGGSPPRSGTALVRVVVVDINDNSPEFEQAFYEVKIRENSILGSLILIVSAWDLDSGTN 274
Query: 1078 ANLTYFIQPSDTDL--PFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXX 1135
+ Y + D+ FEI+ +G +++ LD ET + Y + + A D G
Sbjct: 275 GEICYTFSHASEDIRKTFEINQKSGEITLRAPLDFETIESYSIIIQATDGG---GLFGKS 331
Query: 1136 XXXXXXXDVNDNSPKF--YAFDELLEWKHPEADEL--SNHNFESVMMIPVYKATIEENAP 1191
DVNDN+P+ + + PE + S + +S + +I E+ P
Sbjct: 332 TVIIHVIDVNDNAPEITVSSITSPIPENTPETVVMVFSIQDIDSGDNGRIV-CSIPEDLP 390
Query: 1192 --IGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEV 1249
+ ++V + +T+ + Y++ +LG+P L + V V+DV D
Sbjct: 391 FVLKSSVENYYTLETERPLDRESTAEYNI--TITVTDLGIPRLKTEHNTTVLVSDVND-- 446
Query: 1250 EMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV 1307
+ P F Y L + EN + + + S++ T+ N ++ Y +L D + +
Sbjct: 447 ---NAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVNYSLLPPQDLHLPLASL 503
Query: 1308 --IDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVK 1365
I+ NG L+ +RS D E ++ V A R P + +
Sbjct: 504 VSINTDNGHLFALRSLDYEALQAFDFRVGAT----DRGSPAL-------------SSEAL 546
Query: 1366 VVVRIKDVNDNSP----KFTNGNRPLVTAIPTTAPFGYQVMQLKGAIG 1409
V V + D NDNSP NG+ P +P A GY V ++ G
Sbjct: 547 VRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDG 594
Score = 103 bits (246), Expect = 7e-21
Identities = 111/465 (23%), Positives = 190/465 (40%), Gaps = 36/465 (7%)
Query: 442 FVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQR 501
F+ +E+ + D ND++P+F + + N+ VG V A D D+G N + Y +
Sbjct: 116 FLQIELQVRDINDHSPIFSEKQML-LEIPENSPVGAVFLLESAKDLDVGINAVKSYTISP 174
Query: 502 TSNLTITSPFKINPNTGTVSVAESPILEGRH----ALFVEASDQPANPSERRYSLAVVTI 557
S+ I I N + L+ + + A D + P + VV +
Sbjct: 175 NSHFHIKMRV-IPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVVVV 233
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYE 615
++ + P+F A YE + N +G+ + + D+ ++ Y H E
Sbjct: 234 DINDNS-------PEFEQAFYEVKIRENSILGSLILIVSAWDLDSGTNGEICYTFSHASE 286
Query: 616 E-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERG 674
+ F + ++SG IT+ L Y + + L + +HV+DVND
Sbjct: 287 DIRKTFEINQKSGEITLRAPLDFETIESYSI-IIQATDGGGLFGKSTVIIHVIDVNDNAP 345
Query: 675 VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAE 734
+ S I + EN+ + +F ++ I G + I ++
Sbjct: 346 EI---TVSSITSPIPENTPETVV-MVF--SIQDIDSGDNGRIVCSIPEDLPFVLKSSVEN 399
Query: 735 DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEG 794
T+ T++PLDRE Y +T+ + G+ + T+ + D NDN P F +Y
Sbjct: 400 YYTLETERPLDRESTAEYNITITVT-DLGIPRLKTEHNTTVLVSDVNDNAPTFTQTSYTL 458
Query: 795 FIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDENTGVVKF 848
F+ EN+ I + ATD D GTNA Y+L + ++ + G + F
Sbjct: 459 FVRENNSPALHI---GSVSATDRDSGTNAQVNYSLLPPQDLHLPLASLVSINTDNGHL-F 514
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
SLD E + + A D G LSSEA + +++ D NDN P
Sbjct: 515 ALRSLDYEALQAFDFRVGATDRGSPALSSEALVRVLVLDANDNSP 559
Score = 75.4 bits (177), Expect = 1e-12
Identities = 85/325 (26%), Positives = 140/325 (43%), Gaps = 31/325 (9%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPI--GPSLTIPLTVPRGLT 139
+V +++ DVNDN P + + E TP +F I I G + I ++P L
Sbjct: 332 TVIIHVIDVNDNAPEITVSSITSPIPENTPE-TVVMVFSIQDIDSGDNGRIVCSIPEDLP 390
Query: 140 IF-----KDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
++ + ++P S Y+I ++ D G L++ H +L+ V D
Sbjct: 391 FVLKSSVENYYTLETERPLDRESTAEYNITITVTDLGIPRLKTEHNTTVLVSDVNDNAPT 450
Query: 194 DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLFSLDS 248
+ + + + L + A D+D G A + Y L+ D L S+++
Sbjct: 451 FTQTSYTLFV--RENNSPALHIGSVSATDRDSGTNAQVNYSLLPPQDLHLPLASLVSINT 508
Query: 249 VNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEV 308
NG LF + LD +A LQA F +V A+ +P +++A V + +LD NDN P
Sbjct: 509 DNGHLFALRSLDYEA---LQA--FDFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLY 563
Query: 309 DFYNISI--VENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGW 360
N S E +P G+ V +V+A D D G+N +YQL G F + +G
Sbjct: 564 PLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG- 622
Query: 361 LTVRNQTVLDREAHSSLRMKVYAKE 385
VR +L + R+ V K+
Sbjct: 623 -EVRTARLLSERDAAKHRLVVLVKD 646
Score = 74.9 bits (176), Expect = 2e-12
Identities = 62/236 (26%), Positives = 111/236 (47%), Gaps = 17/236 (7%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLIAN 722
+ V D+ND + + ++ + ENS +G +F + G V+ + I+
Sbjct: 121 LQVRDINDHSPIF---SEKQMLLEIPENSP---VGAVFLLESAKDLDVGINAVKSYTISP 174
Query: 723 QQDVTDDIAIAEDGTIFTQKPLDR--EKRDVYRMT-VIAEFNKGVISGAGIYQVTIYIED 779
+ + D + + LD+ + ++ ++ +++ + G +G V + + D
Sbjct: 175 NSHFHIKMRVIPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVVVVD 234
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM--- 836
NDN P FE A YE I ENS +G+ I I+ A D D GTN YT +++
Sbjct: 235 INDNSPEFEQAFYEVKIRENSILGSLIL---IVSAWDLDSGTNGEICYTFSHASEDIRKT 291
Query: 837 FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
F++++ +G + + LD E Y + + A D GGL ++ +II + D NDN PE
Sbjct: 292 FEINQKSGEIT-LRAPLDFETIESYSIIIQATDGGGLFGKSTVIIHVIDVNDNAPE 346
Score = 68.1 bits (159), Expect = 2e-10
Identities = 57/175 (32%), Positives = 86/175 (49%), Gaps = 17/175 (9%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGS-----LFLEKELDLDAEHNLQANTFVL 274
A D D+G+ A Y IS N + + + L L+K LD + L +F+L
Sbjct: 157 AKDLDVGINAVKSYT-ISPNSHFHIKMRVIPDNRKYPELVLDKALDYE---ELPELSFIL 212
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
A +P ++ A V + ++D+NDN PEFE FY + I EN G +L V A D D
Sbjct: 213 S--ALDGGSPPRSGTALVRVVVVDINDNSPEFEQAFYEVKIRENSILGSLILIVSAWDLD 270
Query: 335 QGENGE----FTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
G NGE F++ +D + F I+ +SG +T+R LD E S + + A +
Sbjct: 271 SGTNGEICYTFSHASEDIRKTFEINQKSGEITLR--APLDFETIESYSIIIQATD 323
Score = 62.1 bits (144), Expect = 1e-08
Identities = 64/220 (29%), Positives = 89/220 (40%), Gaps = 18/220 (8%)
Query: 917 TIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYI 976
T + V N A Q + EN I ++A D DSG N Q+ Y +
Sbjct: 437 TTVLVSDVNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVNYSL-----L 491
Query: 977 PPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVR 1032
PP L L + IN +GH+ RSL E+ F + A D G+ L+ VR
Sbjct: 492 PPQDLH---LPLASLVSINTDNGHLFALRSLDYEALQAFDFRVGATDRGSPALSSEALVR 548
Query: 1033 VFVKDVNDHFPVFKKTWYNFN------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQP 1086
V V D ND+ P N + V A ++ KV A D D GQNA L+Y +
Sbjct: 549 VLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLK 608
Query: 1087 SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+ F + G + L K+ L V+ +DNG
Sbjct: 609 ATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNG 648
Score = 50.8 bits (116), Expect = 4e-05
Identities = 41/138 (29%), Positives = 64/138 (46%), Gaps = 9/138 (6%)
Query: 772 QVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG 831
Q+ + + D ND+ P+F I ENS +G +++ A D D G NA+ YT+
Sbjct: 118 QIELQVRDINDHSPIFSEKQMLLEIPENSPVGAVFLLES---AKDLDVGINAVKSYTISP 174
Query: 832 EGK---EMFDVDENTGVVKFIGD-SLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGD 885
+M + +N + + D +LD E+ L A D G S A + +++ D
Sbjct: 175 NSHFHIKMRVIPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVVVVD 234
Query: 886 ENDNKPEFNQIEENSKVR 903
NDN PEF Q K+R
Sbjct: 235 INDNSPEFEQAFYEVKIR 252
Score = 48.4 bits (110), Expect = 2e-04
Identities = 57/252 (22%), Positives = 98/252 (38%), Gaps = 16/252 (6%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIAN- 722
V VVD+ND + + ++ENS ++ I + + G + + ++
Sbjct: 230 VVVVDINDNSPEFEQAFYE---VKIRENSILGSL--ILIVSAWDLDSGTNGEICYTFSHA 284
Query: 723 QQDVTDDIAIAE-DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
+D+ I + G I + PLD E + Y + + A G+ G V I++ D N
Sbjct: 285 SEDIRKTFEINQKSGEITLRAPLDFETIESYSIIIQATDGGGLF---GKSTVIIHVIDVN 341
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDE 841
DN P ++ I EN T + + D D G N + ++ + +
Sbjct: 342 DNAPEITVSSITSPIPEN----TPETVVMVFSIQDIDSGDNGRIVCSIPEDLPFVLKSSV 397
Query: 842 NTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
LDRE Y +++ D G L +E +++ D NDN P F Q
Sbjct: 398 ENYYTLETERPLDRESTAEYNITITVTDLGIPRLKTEHNTTVLVSDVNDNAPTFTQTSYT 457
Query: 900 SKVRIHRETKLN 911
VR + L+
Sbjct: 458 LFVRENNSPALH 469
Score = 47.6 bits (108), Expect = 3e-04
Identities = 67/317 (21%), Positives = 122/317 (38%), Gaps = 26/317 (8%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP---IGPSLTIPLTV-P 135
+L + + + D+ND+ PIF + + + E +P G F+ A +G + T+ P
Sbjct: 116 FLQIELQVRDINDHSPIFSEKQMLLEIPENSPVGA-VFLLESAKDLDVGINAVKSYTISP 174
Query: 136 RG-----LTIFKDIRAFDR---DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKV 187
+ + D R + DK S + DG S V ++ V
Sbjct: 175 NSHFHIKMRVIPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVV--V 232
Query: 188 LDYDAGDKEFQLVIMASGKRIHKEI-LFPEPIHAIDQDLGVGATLRYELISGND--RKLF 244
+D + EF+ R + + + A D D G + Y ++ RK F
Sbjct: 233 VDINDNSPEFEQAFYEVKIRENSILGSLILIVSAWDLDSGTNGEICYTFSHASEDIRKTF 292
Query: 245 SLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLP 304
++ +G + L LD + ++ + +QA+ ++ V I ++D+NDN P
Sbjct: 293 EINQKSGEITLRAPLDFET-----IESYSIIIQATDGGGLF--GKSTVIIHVIDVNDNAP 345
Query: 305 EFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVR 364
E V I EN P V+ D D G+NG + + + T+
Sbjct: 346 EITVSSITSPIPENTPETV-VMVFSIQDIDSGDNGRIVCSIPEDLPFVLKSSVENYYTLE 404
Query: 365 NQTVLDREAHSSLRMKV 381
+ LDRE+ + + +
Sbjct: 405 TERPLDRESTAEYNITI 421
Score = 44.0 bits (99), Expect = 0.004
Identities = 37/123 (30%), Positives = 56/123 (45%), Gaps = 5/123 (4%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
++S + ++ LD G L L + LD + E VL +Q + NP + Q +E+
Sbjct: 66 VVSNDKKQRLQLDINTGDLLLSETLDRE-ELCGSIEPCVLHLQVL-MQNPTQFLQ--IEL 121
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
++ D+ND+ P F + I EN P G L A D D G N +Y + P F I
Sbjct: 122 QVRDINDHSPIFSEKQMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTI-SPNSHFHI 180
Query: 355 DPR 357
R
Sbjct: 181 KMR 183
Score = 39.9 bits (89), Expect = 0.069
Identities = 38/126 (30%), Positives = 54/126 (42%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 541 LSSEALVRVLVLDANDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 599
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + + + N T + S +H L V D P +L
Sbjct: 600 AWLSYQLLKATEPGLFGVWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 658
Query: 553 AVVTIE 558
V+ ++
Sbjct: 659 QVLLVD 664
>BC112102-1|AAI12103.1| 798|Homo sapiens protocadherin alpha 4,
isoform 2 precursor protein.
Length = 798
Score = 103 bits (246), Expect = 7e-21
Identities = 115/427 (26%), Positives = 183/427 (42%), Gaps = 60/427 (14%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAG--IYQVTIYIEDENDNPPVFEHAT 791
++G +F +DRE ++ R + + VI ++ V + + D NDNPPVF
Sbjct: 80 QNGILFVNSRIDRE--ELCRRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPVFPATQ 137
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD 851
I E+ + + ++ A+DAD G NAL Y L E F +++
Sbjct: 138 KNLSIAESRPLDSRFPLEG---ASDADIGENALLTYRL--SPNEYFSLEKPP-------- 184
Query: 852 SLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
+ +++ L L+ R + E+ +++ + KPE L
Sbjct: 185 ----DDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPE-----------------LT 223
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
GT +I V N A D+ + EN+P GT +IKLNA DLD GLNG I Y F+
Sbjct: 224 GTVQL-LITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFS 282
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN--LND 1027
++ I P+ VK F I+ G +IV + E + + + +D G L+
Sbjct: 283 ND--ISPN--------VKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSG 332
Query: 1028 NISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
+ V V V+D ND+ P + + + E V+ + +D D G N +T +
Sbjct: 333 HCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSL--- 389
Query: 1088 DTDLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDV 1144
+ +PF+ +S S ++ LDRE+ Y L V ARD G DV
Sbjct: 390 TSHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGG-SPSLWATASVSVEVADV 448
Query: 1145 NDNSPKF 1151
NDN+P F
Sbjct: 449 NDNAPAF 455
Score = 88.6 bits (210), Expect = 1e-16
Identities = 111/464 (23%), Positives = 197/464 (42%), Gaps = 35/464 (7%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + +T+LDANDN P F +Y+ + N GT++ K+ A D D G NG ++Y
Sbjct: 221 ELTGTVQLLITVLDANDNAPAF-DRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVY 279
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + S F I+P TG + V E + + VE D+ P V
Sbjct: 280 SFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGH---CRV 336
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+EV + N ++PD + + +GT + I V+D + V+ +
Sbjct: 337 IVEV----EDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSD--KDMGVNGLVTCSLT 390
Query: 616 EGVPF-AVEERSGVITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVND 671
VPF V ++V D L R + Y+ A + +L + +V V DVND
Sbjct: 391 SHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVND 450
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLI----ANQQDVT 727
+ ++ +F VKEN+ IF + V + + ++ ++
Sbjct: 451 NAPAFAQPEYT--VF-VKENNPPGC--HIFTVSAWDADAQENALVSYSLVERRVGERALS 505
Query: 728 DDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
+++ AE G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 506 SYVSVHAESGKVYALQPLDHEELELLQFQVTAR-DAGVPPLGSNVTLQVFVLDENDNAPA 564
Query: 787 FEHATYEGFIMENSK-IGTEIKMDNI---IKATDADEGTNALFMYTL---FGEGKEMFDV 839
G S+ + + + ++ ++A DAD G NA Y L G + F V
Sbjct: 565 LLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRV 624
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMI 883
TG + +LD ++L ++ +D G + A +++
Sbjct: 625 GLYTGEIS-TTRALDETDAPRHRLLVLVKDHGEPALTATATVLV 667
Score = 74.1 bits (174), Expect = 3e-12
Identities = 104/475 (21%), Positives = 180/475 (37%), Gaps = 30/475 (6%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +V+V + D NDN PVF P+ S+ + + + A D D+G
Sbjct: 105 HLEVIVDRPLQVFHVDVEVRDINDNPPVF-PATQKNLSIAESRPLDSRFPLEGASDADIG 163
Query: 491 QNGMVLYDLQRTSNLTITSP--FKINPNTGTVSVAESPILEGRHALFVEASDQPANPSER 548
+N ++ Y L ++ P ++ G + E V + P
Sbjct: 164 ENALLTYRLSPNEYFSLEKPPDDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPE-- 221
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDV 606
T+++ + P F Y+ + NV GT V ++ +D E D+
Sbjct: 222 ----LTGTVQLLITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDI 277
Query: 607 SYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
Y + V F ++ +G I V + Y+ + + L + + V
Sbjct: 278 VYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGI-DKGQLPLSGHCRV 336
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
+V+V D + + ++E++ + + + + NG V + +
Sbjct: 337 -IVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGL--VTCSLTSHV 393
Query: 725 DVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
++ LDRE Y + V A + G S V++ + D NDN
Sbjct: 394 PFKLVSTFKNYYSLVLDSALDRESVSAYELVVTAR-DGGSPSLWATASVSVEVADVNDNA 452
Query: 785 PVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF----GEG--KEMFD 838
P F Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 453 PAFAQPEYTVFVKENNPPGCHIFT---VSAWDADAQENALVSYSLVERRVGERALSSYVS 509
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 510 VHAESGKVYAL-QPLDHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAP 563
Score = 72.9 bits (171), Expect = 8e-12
Identities = 52/157 (33%), Positives = 78/157 (49%), Gaps = 20/157 (12%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDS------VNG-SLFLEKELDLDAEHNLQANTF 272
A D D+G A L Y L + + FSL+ V G L L K LD + +A
Sbjct: 157 ASDADIGENALLTYRL---SPNEYFSLEKPPDDELVKGLGLILRKSLDRE-----EAPEI 208
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
L + A+ P T ++ I +LD NDN P F+ Y + ++EN+PNG V+++ A+D
Sbjct: 209 FLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASD 268
Query: 333 KDQGENGEFTYQLDDP-----KGAFSIDPRSGWLTVR 364
D+G NG+ Y + K F IDP +G + V+
Sbjct: 269 LDEGLNGDIVYSFSNDISPNVKSKFHIDPITGQIIVK 305
Score = 67.3 bits (157), Expect = 4e-10
Identities = 73/290 (25%), Positives = 115/290 (39%), Gaps = 18/290 (6%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L G +++ + + + + D NDN P F T Y V + E P G + +
Sbjct: 212 LTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDE 271
Query: 127 SLTIPLTVPRGLTIFKDIRAFDRDKPNT-----------PNSDVHYSIVSGNDDGHFALE 175
L + I ++++ P T S + IV G D G L
Sbjct: 272 GLNGDIVYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPL- 330
Query: 176 SSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
S H V++ + + + D EF+ + + + + I D+D+GV + L
Sbjct: 331 SGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIAL-ISVSDKDMGVNGLVTCSL 389
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIE 295
S KL S SL L+ LD ++ + + L V A +P A A V +E
Sbjct: 390 TSHVPFKLVSTFKNYYSLVLDSALDRES-----VSAYELVVTARDGGSPSLWATASVSVE 444
Query: 296 LLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+ D+NDN P F Y + + EN P G + V A D D EN +Y L
Sbjct: 445 VADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSL 494
Score = 63.7 bits (148), Expect = 5e-09
Identities = 48/164 (29%), Positives = 75/164 (45%), Gaps = 6/164 (3%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I + +D E+ Y + ++ +KG + +G +V + +ED NDN P E +
Sbjct: 300 GQIIVKGYIDFEESKSYEI-IVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLP 358
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
I E++ +GT I + I +D D G N L +L + +LDR
Sbjct: 359 IREDAPLGTVIAL---ISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSALDR 415
Query: 856 EKKIMYKLSLVARDTGGLS--SEAELIIMIGDENDNKPEFNQIE 897
E Y+L + ARD G S + A + + + D NDN P F Q E
Sbjct: 416 ESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPE 459
Score = 63.3 bits (147), Expect = 6e-09
Identities = 50/172 (29%), Positives = 83/172 (48%), Gaps = 14/172 (8%)
Query: 728 DDIAIAEDGTIFTQKPLDREKR-DVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
DD + G I +K LDRE+ +++ + + K ++G Q+ I + D NDN P
Sbjct: 185 DDELVKGLGLIL-RKSLDREEAPEIFLVLTATDGGKPELTGT--VQLLITVLDANDNAPA 241
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGE----GKEMFDVDEN 842
F+ Y+ ++EN GT + N A+D DEG N +Y+ + K F +D
Sbjct: 242 FDRTIYKVRLLENVPNGTLVIKLN---ASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPI 298
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIGDENDNKPE 892
TG + + +D E+ Y++ + D G L S +I+ + D NDN P+
Sbjct: 299 TGQI-IVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPD 349
Score = 59.7 bits (138), Expect = 8e-08
Identities = 62/221 (28%), Positives = 94/221 (42%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y E +
Sbjct: 443 VEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSL-VERRVGE 501
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVF 1034
LS+ Y ++ G V + L E + ++A D G L N++++VF
Sbjct: 502 RALSS-------YVSVHAESGKVYALQPLDHEELELLQFQVTARDAGVPPLGSNVTLQVF 554
Query: 1035 VKDVNDHFPVF---KKTWYNFNVEE----AQYTRRVLGKVDATDADFGQNANLTYFIQP- 1086
V D ND+ P + V E + V+ KV A DAD G NA L+Y +QP
Sbjct: 555 VLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPG 614
Query: 1087 -SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+PF + TG +S LD ++ L V+ +D+G
Sbjct: 615 TGGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHG 655
Score = 59.3 bits (137), Expect = 1e-07
Identities = 70/245 (28%), Positives = 105/245 (42%), Gaps = 23/245 (9%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
I+EV+ N D++ I E+ P+GT I ++ D D G+NG + S V
Sbjct: 337 IVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHV--- 393
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRV 1033
P KL + K Y+ + ++ +L ES + L ++A DGG+ L SV V
Sbjct: 394 PFKLVST---FKNYYSL-------VLDSALDRESVSAYELVVTARDGGSPSLWATASVSV 443
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTD 1090
V DVND+ P F + Y V+E + V A DAD +NA ++Y + + +
Sbjct: 444 EVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERA 503
Query: 1091 LPFEIS--PLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
L +S +G + LD E + V ARD G D NDN+
Sbjct: 504 LSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDAG-VPPLGSNVTLQVFVLDENDNA 562
Query: 1149 PKFYA 1153
P A
Sbjct: 563 PALLA 567
Score = 47.6 bits (108), Expect = 3e-04
Identities = 52/186 (27%), Positives = 85/186 (45%), Gaps = 18/186 (9%)
Query: 175 ESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVG-ATL-- 231
+ S + +LLL + ++AG+ + + K H + I QDLG+ A L
Sbjct: 9 QESRRLLLLLLLLAAWEAGNGQLHYSVSEEAK--HGTF-----VGRIAQDLGLELAELVP 61
Query: 232 -RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQVQASQLNNPLKTAQ 289
+ + S L ++ NG LF+ +D + A + L+V ++ PL+
Sbjct: 62 RLFRVASKGRGGLLEVNLQNGILFVNSRIDREELCRRSAECSIHLEVI---VDRPLQVFH 118
Query: 290 ARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
V++E+ D+NDN P F N+SI E+ P A+D D GEN TY+L P
Sbjct: 119 --VDVEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRL-SPN 175
Query: 350 GAFSID 355
FS++
Sbjct: 176 EYFSLE 181
Score = 46.0 bits (104), Expect = 0.001
Identities = 32/108 (29%), Positives = 52/108 (48%), Gaps = 7/108 (6%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++TV D D + P F Y++ + ENV ++ LN ++ E
Sbjct: 218 GKPELTGTVQLLITVLDAND-----NAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIV 1333
N + Y N+ +++ F IDP G + + D E +YE+IV
Sbjct: 273 LNGDIVYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIV 320
Score = 43.6 bits (98), Expect = 0.006
Identities = 90/377 (23%), Positives = 147/377 (38%), Gaps = 36/377 (9%)
Query: 44 VDSDSPQNVVKFRLGCDFDEGDDLVRIGAGLNQ----ISAYLSVTVYIEDVNDNVPIFLD 99
+D + Q +VK + DF+E I G+++ +S + V V +ED NDNVP
Sbjct: 295 IDPITGQIIVKGYI--DFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEF 352
Query: 100 TPYHVTVDELTPTGEKAFIFLIAP----IGPSLTIPLT--VPRGL-TIFKDIRAFDRDKP 152
+ + E P G + ++ + +T LT VP L + FK+ + D
Sbjct: 353 KSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSA 412
Query: 153 NTPNSDVHYS-IVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKE 211
S Y +V+ D G +L ++ + + V D + + +
Sbjct: 413 LDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGC 472
Query: 212 ILFPEPIHAIDQDLGVGATLRYELISGN--DRKLFSLDSVN---GSLFLEKELDLDAEHN 266
+F + A D D A + Y L+ +R L S SV+ G ++ + LD +
Sbjct: 473 HIFT--VSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELEL 530
Query: 267 LQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLP--- 320
LQ QV A P + +++ +LD NDN P ++ E +P
Sbjct: 531 LQ-----FQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSV 585
Query: 321 -NGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLT--VRNQTVLDREAHSSL 377
G V +V A D D G N +Y+L G I R G T + LD
Sbjct: 586 GVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAPRH 645
Query: 378 RMKVYAKE-TNPSVVGT 393
R+ V K+ P++ T
Sbjct: 646 RLLVLVKDHGEPALTAT 662
>AY013878-1|AAK21988.1| 776|Homo sapiens protocadherin beta 8a
protein.
Length = 776
Score = 103 bits (246), Expect = 7e-21
Identities = 127/496 (25%), Positives = 208/496 (41%), Gaps = 69/496 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P+GT +ALDLD G N Y+ + P S E F ++
Sbjct: 142 IPENSPLGTEFPLNHALDLDVGSNNVQNYKIS-----PSSHFRVLIHE----FRDGRKYP 192
Query: 1000 HVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+++ + L E E RL ++ALDGG+ + VR+ V D+ND+ P F++ Y +
Sbjct: 193 ELVLDKELDREEEPQLRLTLTALDGGSPPRSGTAQVRIEVVDINDNAPEFEQPIYKVQIP 252
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTY-FIQPS-DTDLPFEISPLTGVLSVNGELDRETE 1113
E ++ V A D D G N ++Y QPS D E++P+TG + + ++D E
Sbjct: 253 ENSPLGSLVATVSARDLDGGANGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFEMV 312
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK--FYAFDELLEWKHPE------- 1164
Y + + A D G DVNDN P+ A + PE
Sbjct: 313 TSYEVRIKATDGG---GLSGKCTLLLQVVDVNDNPPQVTMSALTSPIPENSPEIVVAVFS 369
Query: 1165 -ADELSNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQR 1221
+D S +N +++ ++I+E+ P + +V + T+ + Y++
Sbjct: 370 VSDPDSGNNGKTI-------SSIQEDLPFLLKPSVKNFYTLVTERALDREARAEYNI--T 420
Query: 1222 KNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL 1281
++G P L + + V ++DV D + P F Y L + EN + + + S++
Sbjct: 421 LTVTDMGTPRLKTEHNITVQISDVND-----NAPTFTQTSYTLFVRENNSPALHIGSVSA 475
Query: 1282 TEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREVKDTYEVIVRAER 1337
T+ N ++ Y +L D + + I+ NG L+ +RS D E +E V A
Sbjct: 476 TDRDSGTNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEALREFEFRVSAT- 534
Query: 1338 QKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTNGNRPLVTAIPT 1393
R P + + V V + D NDNSP NG+ P +P
Sbjct: 535 ---DRGSPAL-------------SSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPR 578
Query: 1394 TAPFGYQVMQLKGAIG 1409
A GY V ++ G
Sbjct: 579 AAEPGYLVTKVVAVDG 594
Score = 93.5 bits (222), Expect = 5e-18
Identities = 116/472 (24%), Positives = 197/472 (41%), Gaps = 40/472 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E + E+ ++D ND++P+F + + N+ +GT A+D D+G N +
Sbjct: 111 ENPLEIFQAELRVIDINDHSPMFTEKEMI-LKIPENSPLGTEFPLNHALDLDVGSNNVQN 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLA 553
Y + +S+ + + V + + E + L + A D + P R A
Sbjct: 170 YKISPSSHFRVLIHEFRDGRKYPELVLDKELDREEEPQLRLTLTALDGGSPP---RSGTA 226
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLL 611
V IEV + P+F Y+ + N +G+ V + D +SY L
Sbjct: 227 QVRIEVV----DINDNAPEFEQPIYKVQIPENSPLGSLVATVSARDLDGGANGKISYTLF 282
Query: 612 HGYEE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
E+ V +G + + + Y+ A + LS + VVDVN
Sbjct: 283 QPSEDISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIKAT-DGGGLSGKCTLLLQVVDVN 341
Query: 671 DERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D V + SPI ENS + ++ S GN N + + + Q+D+
Sbjct: 342 DNPPQVTMSALTSPI----PENSPEIVVAVFSVSDPDS--GN---NGKTISSIQEDLPFL 392
Query: 730 I--AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVF 787
+ ++ T+ T++ LDRE R Y +T+ + G + +T+ I D NDN P F
Sbjct: 393 LKPSVKNFYTLVTERALDREARAEYNITLTVT-DMGTPRLKTEHNITVQISDVNDNAPTF 451
Query: 788 EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDE 841
+Y F+ EN+ I + ATD D GTNA Y+L + ++
Sbjct: 452 TQTSYTLFVRENNSPALHI---GSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINA 508
Query: 842 NTGVVKFIGDSLDRE--KKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKP 891
+ G + F SLD E ++ +++S R + LSSEA + +++ D NDN P
Sbjct: 509 DNGHL-FALRSLDYEALREFEFRVSATDRGSPALSSEALVRVLVLDANDNSP 559
Score = 89.8 bits (213), Expect = 6e-17
Identities = 73/242 (30%), Positives = 116/242 (47%), Gaps = 19/242 (7%)
Query: 659 VTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR- 717
+ A + V+D+ND + + +I + ENS +G F N + G+ NV+
Sbjct: 116 IFQAELRVIDINDHSPMFTE---KEMILKIPENSP---LGTEFPLNHALDLDVGSNNVQN 169
Query: 718 FLIANQQDVTDDIAIAEDGTIFTQ----KPLDREKRDVYRMTVIAEFNKGVISGAGIYQV 773
+ I+ I DG + + K LDRE+ R+T+ A + G +G QV
Sbjct: 170 YKISPSSHFRVLIHEFRDGRKYPELVLDKELDREEEPQLRLTLTA-LDGGSPPRSGTAQV 228
Query: 774 TIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG 833
I + D NDN P FE Y+ I ENS +G+ + + A D D G N YTLF
Sbjct: 229 RIEVVDINDNAPEFEQPIYKVQIPENSPLGSLVAT---VSARDLDGGANGKISYTLFQPS 285
Query: 834 KEM---FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNK 890
+++ +V+ TG V+ + +D E Y++ + A D GGLS + L++ + D NDN
Sbjct: 286 EDISKTLEVNPMTGEVR-LRKQVDFEMVTSYEVRIKATDGGGLSGKCTLLLQVVDVNDNP 344
Query: 891 PE 892
P+
Sbjct: 345 PQ 346
Score = 81.8 bits (193), Expect = 2e-14
Identities = 54/170 (31%), Positives = 85/170 (50%), Gaps = 13/170 (7%)
Query: 219 HAIDQDLGVGATLRYELISGNDRKLFSLDSVNG----SLFLEKELDLDAEHNLQANTFVL 274
HA+D D+G Y++ + ++ + +G L L+KELD + E L+ L
Sbjct: 156 HALDLDVGSNNVQNYKISPSSHFRVLIHEFRDGRKYPELVLDKELDREEEPQLR-----L 210
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A +P ++ A+V IE++D+NDN PEFE Y + I EN P G V V A D D
Sbjct: 211 TLTALDGGSPPRSGTAQVRIEVVDINDNAPEFEQPIYKVQIPENSPLGSLVATVSARDLD 270
Query: 335 QGENGEFTYQLDDPKGAFS----IDPRSGWLTVRNQTVLDREAHSSLRMK 380
G NG+ +Y L P S ++P +G + +R Q + +R+K
Sbjct: 271 GGANGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIK 320
Score = 76.2 bits (179), Expect = 9e-13
Identities = 74/246 (30%), Positives = 105/246 (42%), Gaps = 22/246 (8%)
Query: 911 NGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEF 970
+GTA I EV N A + +Q IPEN P+G+ + ++A DLD G NG+I Y
Sbjct: 223 SGTAQVRI-EVVDINDNAPEFEQPIYKVQIPENSPLGSLVATVSARDLDGGANGKISY-- 279
Query: 971 NSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDN 1028
PS+ + LEV N G V + + + E + + + I A DGG L+
Sbjct: 280 ---TLFQPSEDISKTLEV------NPMTGEVRLRKQVDFEMVTSYEVRIKATDGGGLSGK 330
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
++ + V DVND+ P + + E V+ +D D G N IQ
Sbjct: 331 CTLLLQVVDVNDNPPQVTMSALTSPIPE-NSPEIVVAVFSVSDPDSGNNGKTISSIQ--- 386
Query: 1089 TDLPFEISPLTG---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
DLPF + P L LDRE +Y +T+ D G DVN
Sbjct: 387 EDLPFLLKPSVKNFYTLVTERALDREARAEYNITLTVTDMG-TPRLKTEHNITVQISDVN 445
Query: 1146 DNSPKF 1151
DN+P F
Sbjct: 446 DNAPTF 451
Score = 68.1 bits (159), Expect = 2e-10
Identities = 81/299 (27%), Positives = 116/299 (38%), Gaps = 22/299 (7%)
Query: 858 KIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAG-- 915
KI Y L + D +S E+ M G+ K ++ + +VRI + T G +G
Sbjct: 276 KISYTLFQPSED---ISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRI-KATDGGGLSGKC 331
Query: 916 FTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVY 975
+++V N V IPEN P + + D DSG NG+ ++
Sbjct: 332 TLLLQVVDVNDNPPQVTMSALTSPIPENSP-EIVVAVFSVSDPDSGNNGKTISSIQEDL- 389
Query: 976 IPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVFV 1035
P L Y ++ ER + R E L ++ + L ++ V +
Sbjct: 390 --PFLLKPSVKNF--YTLVTER----ALDREARAEYNITLTVTDMGTPRLKTEHNITVQI 441
Query: 1036 KDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSDTDLPF- 1093
DVND+ P F +T Y V E +G V ATD D G NA +TY + P D LP
Sbjct: 442 SDVNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLA 501
Query: 1094 ---EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
I+ G L LD E ++ V A D G D NDNSP
Sbjct: 502 SLVSINADNGHLFALRSLDYEALREFEFRVSATDRG-SPALSSEALVRVLVLDANDNSP 559
Score = 62.9 bits (146), Expect = 9e-09
Identities = 62/218 (28%), Positives = 89/218 (40%), Gaps = 18/218 (8%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+++ N A Q + EN I ++A D DSG N Q+ Y +PP
Sbjct: 439 VQISDVNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSL-----LPP 493
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVF 1034
L + IN +GH+ RSL E+ EF +SA D G+ L+ VRV
Sbjct: 494 QD---PHLPLASLVSINADNGHLFALRSLDYEALREFEFRVSATDRGSPALSSEALVRVL 550
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQPSD 1088
V D ND+ P N + + R ++ KV A D D GQNA L+Y + +
Sbjct: 551 VLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKAT 610
Query: 1089 TDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
F + G + L K L V+ +DNG
Sbjct: 611 EPGLFGVWAHNGEVRTARLLSERDAAKQRLVVLVKDNG 648
Score = 60.9 bits (141), Expect = 3e-08
Identities = 53/181 (29%), Positives = 82/181 (45%), Gaps = 20/181 (11%)
Query: 218 IHAIDQDLGVGATLRYELISGND-----RKLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A D+D G A + Y L+ D L S+++ NG LF + LD +A F
Sbjct: 473 VSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEA-----LREF 527
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNIS--IVENLPN----GFSVL 326
+V A+ +P +++A V + +LD NDN P N S E +P G+ V
Sbjct: 528 EFRVSATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVT 587
Query: 327 QVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAK 384
+V+A D D G+N +YQL G F + +G VR +L + R+ V K
Sbjct: 588 KVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG--EVRTARLLSERDAAKQRLVVLVK 645
Query: 385 E 385
+
Sbjct: 646 D 646
Score = 60.1 bits (139), Expect = 6e-08
Identities = 50/169 (29%), Positives = 78/169 (46%), Gaps = 9/169 (5%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
A+ G + + LDRE+ I F + + I+Q + + D ND+ P+F
Sbjct: 79 AQTGDLLINEKLDREELCGPTEPCILHFQVLMENPLEIFQAELRVIDINDHSPMFTEKEM 138
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF---- 848
I ENS +GTE +++ A D D G+N + Y + + E K+
Sbjct: 139 ILKIPENSPLGTEFPLNH---ALDLDVGSNNVQNYKISPSSHFRVLIHEFRDGRKYPELV 195
Query: 849 IGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+ LDRE++ +L+L A D G S A++ I + D NDN PEF Q
Sbjct: 196 LDKELDREEEPQLRLTLTALDGGSPPRSGTAQVRIEVVDINDNAPEFEQ 244
Score = 57.6 bits (133), Expect = 3e-07
Identities = 86/364 (23%), Positives = 141/364 (38%), Gaps = 51/364 (14%)
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD----TD 1090
V D+NDH P+F + + E A D D G N Y I PS
Sbjct: 123 VIDINDHSPMFTEKEMILKIPENSPLGTEFPLNHALDLDVGSNNVQNYKISPSSHFRVLI 182
Query: 1091 LPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
F L ++ ELDRE E + LT+ A D G D+NDN+P+
Sbjct: 183 HEFRDGRKYPELVLDKELDREEEPQLRLTLTALDGG-SPPRSGTAQVRIEVVDINDNAPE 241
Query: 1151 FYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNG 1210
F + P +YK I EN+P+G+ VA V A D D G
Sbjct: 242 F---------EQP-----------------IYKVQIPENSPLGSLVATVSARDLD--GGA 273
Query: 1211 NGLILYSL--PQRKNQQNLGLPSLSSTAIL-------MVTVADV----PDEVEMSDKPVF 1257
NG I Y+L P + L + ++ L MVT +V D +S K
Sbjct: 274 NGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIKATDGGGLSGKCTL 333
Query: 1258 ISRYYELEIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYL 1317
+ + ++ + + ++ + E+ + + +++ D+ + + +L
Sbjct: 334 LLQVVDVN-DNPPQVTMSALTSPIPENSPEIVVAVFSVSDPDSGNNGKTISSIQEDLPFL 392
Query: 1318 VRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNS 1377
++ VK+ Y ++ + +R + I D+ K + + V+I DVNDN+
Sbjct: 393 LKP---SVKNFYTLVTERALDREAR-AEYNITLTVTDMGTPRLKTEHNITVQISDVNDNA 448
Query: 1378 PKFT 1381
P FT
Sbjct: 449 PTFT 452
Score = 54.8 bits (126), Expect = 2e-06
Identities = 71/291 (24%), Positives = 112/291 (38%), Gaps = 16/291 (5%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPI-- 124
L + G S V + + D+NDN P F Y V + E +P G +
Sbjct: 212 LTALDGGSPPRSGTAQVRIEVVDINDNAPEFEQPIYKVQIPENSPLGSLVATVSARDLDG 271
Query: 125 GPSLTIPLTVPR-GLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALES---SHKP 180
G + I T+ + I K + V + +V+ + A + S K
Sbjct: 272 GANGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIKATDGGGLSGKC 331
Query: 181 VLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND 240
LLL+ V D D Q+ + A I + PE + A+ + + IS
Sbjct: 332 TLLLQVV---DVNDNPPQVTMSALTSPIPENS--PEIVVAVFSVSDPDSGNNGKTISSIQ 386
Query: 241 RKL-FSLD-SVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
L F L SV L E LD E + N + + + + P + + +++ D
Sbjct: 387 EDLPFLLKPSVKNFYTLVTERALDREARAEYN---ITLTVTDMGTPRLKTEHNITVQISD 443
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
+NDN P F Y + + EN + V ATD+D G N + TY L P+
Sbjct: 444 VNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQ 494
Score = 48.0 bits (109), Expect = 3e-04
Identities = 48/172 (27%), Positives = 79/172 (45%), Gaps = 14/172 (8%)
Query: 221 IDQDLGVG----ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ +DLG+G +T + +IS +++ L + G L + ++LD + E +L
Sbjct: 48 LGKDLGLGLTEMSTRKARIISQGNKQHLQLKAQTGDLLINEKLDRE-ELCGPTEPCILHF 106
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
Q + NPL+ QA E+ ++D+ND+ P F + I EN P G A D D G
Sbjct: 107 QVL-MENPLEIFQA--ELRVIDINDHSPMFTEKEMILKIPENSPLGTEFPLNHALDLDVG 163
Query: 337 ENGEFTYQLDDPKGAFSI---DPRSG--WLTVRNQTVLDREAHSSLRMKVYA 383
N Y++ P F + + R G + + LDRE LR+ + A
Sbjct: 164 SNNVQNYKI-SPSSHFRVLIHEFRDGRKYPELVLDKELDREEEPQLRLTLTA 214
Score = 41.9 bits (94), Expect = 0.017
Identities = 35/161 (21%), Positives = 72/161 (44%), Gaps = 12/161 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGND--RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A D D G + Y L ++ K ++ + G + L K++D + ++ ++
Sbjct: 264 VSARDLDGGANGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFE-----MVTSYEVR 318
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
++A+ + + + ++++D+NDN P+ + I EN P V +D D
Sbjct: 319 IKATDGGG--LSGKCTLLLQVVDVNDNPPQVTMSALTSPIPENSPE-IVVAVFSVSDPDS 375
Query: 336 GENGEFTYQLDDPKGAFSIDPR-SGWLTVRNQTVLDREAHS 375
G NG+ + + F + P + T+ + LDREA +
Sbjct: 376 GNNGKTISSIQEDL-PFLLKPSVKNFYTLVTERALDREARA 415
Score = 37.5 bits (83), Expect = 0.37
Identities = 37/127 (29%), Positives = 58/127 (45%), Gaps = 10/127 (7%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 541 LSSEALVRVLVLDANDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 599
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVS-VAESPILEGRHALFVEASDQPANPSERRYS 551
+ Y L + + + + N T ++E + R + V+ + +P P +
Sbjct: 600 AWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKQRLVVLVKDNGEP--PRSATAT 657
Query: 552 LAVVTIE 558
L V+ ++
Sbjct: 658 LHVLLVD 664
>AK093818-1|BAC04231.1| 455|Homo sapiens protein ( Homo sapiens
cDNA FLJ36499 fis, clone THYMU2019197, weakly similar to
Homo sapiens FLAMINGO 1 mRNA. ).
Length = 455
Score = 103 bits (246), Expect = 7e-21
Identities = 113/437 (25%), Positives = 185/437 (42%), Gaps = 31/437 (7%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
V V + D ND PVF ++ A +GT + V+A D D G G+V Y + +
Sbjct: 15 VIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAE 74
Query: 505 LTITSPFKINPNTGTVSVAESPILEGR--HALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F+I+ +TG + E + + + V A+DQ A P + + +T+
Sbjct: 75 ----GKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQ-APPFNQGFCSVYITL----- 124
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSY--DLLHGYEEGVPF 620
+ F A YE + N+ +GT + +++ N ++Y D + F
Sbjct: 125 -LNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFDAYTSTQAKALF 183
Query: 621 AVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGA 680
++ +GVITV + R Y VA + T + V+D ND +
Sbjct: 184 KIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDS-TVVYITVLDENDNSPRFDFTS 242
Query: 681 HSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGT-GNVRFLIANQQDV-TDDIAIAED--G 736
S + + E+ +GQ T + G+ G V F +A+ +I D G
Sbjct: 243 DSAV--SIPED---CPVGQQVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIG 297
Query: 737 TIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHA-TYEGF 795
+F +PLDRE+ D Y + V+A ++G + + + I D NDNPPV E Y
Sbjct: 298 EVFVARPLDREELDHYILQVVAS-DRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVS 356
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM-FDVDENTGVVKFIGDSLD 854
+ EN GT + ++ATD D G N++ Y + K+M F +D +G + D
Sbjct: 357 VNENVGGGTAVVQ---VRATDRDIGINSVLSYYITEGNKDMTFRMDRISGEIATRPAPPD 413
Query: 855 REKKIMYKLSLVARDTG 871
RE++ Y L D G
Sbjct: 414 RERQSFYHLVATVEDEG 430
Score = 82.2 bits (194), Expect = 1e-14
Identities = 72/232 (31%), Positives = 111/232 (47%), Gaps = 10/232 (4%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIAN 722
V+V D+NDE V + +S + ++E + G ++ + T+ S G+G G V + I +
Sbjct: 17 VYVEDINDEAPVFTQQQYSRL--GLRETAGIGTSVIVVQATDRDS--GDG-GLVNYRILS 71
Query: 723 QQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEND 782
+ +I G I T LD E + Y M V A ++ G V I + +E D
Sbjct: 72 GAEGKFEID-ESTGLIITVNYLDYETKTSYMMNVSAT-DQAPPFNQGFCSVYITLLNELD 129
Query: 783 NPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDEN 842
F +A+YE I+EN +GTEI + ++ T YT + K +F +D
Sbjct: 130 EAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFDAYTST-QAKALFKIDAI 188
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFN 894
TGV+ G +DREK Y L++VA D G + I + DENDN P F+
Sbjct: 189 TGVITVQG-LVDREKGDFYTLTVVADDGGPKVDSTVVYITVLDENDNSPRFD 239
Score = 76.6 bits (180), Expect = 6e-13
Identities = 61/194 (31%), Positives = 94/194 (48%), Gaps = 18/194 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPE+ P+G + + A D D+G NGQ+ V+ S A A E+ N+ G
Sbjct: 248 IPEDCPVGQQVATVKAWDPDAGSNGQV-------VFSLASGNIAGAFEI---VTTNDSIG 297
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFKKTW-YNFN 1053
V VAR L E + L + A D G D+I ++V + D+ND+ PV + + YN +
Sbjct: 298 EVFVARPLDREELDHYILQVVASDRGTPPRKKDHI-LQVTILDINDNPPVIESPFGYNVS 356
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVN-GELDRET 1112
V E + +V ATD D G N+ L+Y+I + D+ F + ++G ++ DRE
Sbjct: 357 VNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMTFRMDRISGEIATRPAPPDRER 416
Query: 1113 EDKYILTVVARDNG 1126
+ Y L D G
Sbjct: 417 QSFYHLVATVEDEG 430
Score = 76.6 bits (180), Expect = 6e-13
Identities = 53/164 (32%), Positives = 83/164 (50%), Gaps = 12/164 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTFVL 274
+ A D D G + + L SGN F + + N G +F+ + LD + + + ++L
Sbjct: 261 VKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDRE-----ELDHYIL 315
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDF-YNISIVENLPNGFSVLQVMATDK 333
QV AS P + +++ +LD+NDN P E F YN+S+ EN+ G +V+QV ATD+
Sbjct: 316 QVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDR 375
Query: 334 DQGENGEFTYQLDDPKG--AFSIDPRSGWLTVRNQTVLDREAHS 375
D G N +Y + + F +D SG + R DRE S
Sbjct: 376 DIGINSVLSYYITEGNKDMTFRMDRISGEIATR-PAPPDRERQS 418
Score = 70.9 bits (166), Expect = 3e-11
Identities = 84/315 (26%), Positives = 137/315 (43%), Gaps = 23/315 (7%)
Query: 587 GIGTSVGQIRVNDAFEQND--VSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYD 644
GIGTSV ++ D + V+Y +L G E F ++E +G+I V+ L + Y
Sbjct: 44 GIGTSVIVVQATDRDSGDGGLVNYRILSGAEG--KFEIDESTGLIITVNYLDYETKTSYM 101
Query: 645 FEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTN 704
A + + +V++ +N E ++ +++ + EN A +I
Sbjct: 102 MNVSATDQAPPFN-QGFCSVYITLLN-ELDEAVQFSNASYEAAILENLALGT--EIVRVQ 157
Query: 705 MSSIYGNGTGNVRFLIANQQDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKG 763
SI RF I A G I Q +DREK D Y +TV+A+
Sbjct: 158 AYSIDNLNQITYRFDAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGP 217
Query: 764 VISGAGIYQVTIYIEDENDNPPVFEHATYEGF-IMENSKIGTEIKMDNIIKATDADEGTN 822
+ +Y I + DENDN P F+ + I E+ +G ++ +KA D D G+N
Sbjct: 218 KVDSTVVY---ITVLDENDNSPRFDFTSDSAVSIPEDCPVGQQVAT---VKAWDPDAGSN 271
Query: 823 ALFMYTL----FGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAE 878
+++L E+ +++ G V F+ LDRE+ Y L +VA D G + +
Sbjct: 272 GQVVFSLASGNIAGAFEIVTTNDSIGEV-FVARPLDREELDHYILQVVASDRGTPPRKKD 330
Query: 879 LIIMIG--DENDNKP 891
I+ + D NDN P
Sbjct: 331 HILQVTILDINDNPP 345
Score = 66.1 bits (154), Expect = 9e-10
Identities = 107/420 (25%), Positives = 168/420 (40%), Gaps = 58/420 (13%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
E IGT++I + A D DSG G + Y S E K F I+E G +
Sbjct: 41 ETAGIGTSVIVVQATDRDSGDGGLVNYRILS------------GAEGK--FEIDESTGLI 86
Query: 1002 IVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVN--DHFPVFKKTWYNFNVEEA 1057
I L E++ + +N+SA D + V++ +N D F Y + E
Sbjct: 87 ITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILEN 146
Query: 1058 QYTRRVLGKVDATDADFGQNAN-LTY-FIQPSDTDLP--FEISPLTGVLSVNGELDRETE 1113
+ +V A D N N +TY F + T F+I +TGV++V G +DRE
Sbjct: 147 LALGTEIVRVQAYSID---NLNQITYRFDAYTSTQAKALFKIDAITGVITVQGLVDREKG 203
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF-YAFDELLEWKHPEADELSNHN 1172
D Y LTVVA D G D NDNSP+F + D + PE +
Sbjct: 204 DFYTLTVVADDGG---PKVDSTVVYITVLDENDNSPRFDFTSDSAV--SIPEDCPVG--- 255
Query: 1173 FESVMMIPVYKATIEENAPIGTTVAK-VFANDTDFIGNGN--GLILYSLPQRKNQ----- 1224
+ V + + N + ++A A + + + G + + P + +
Sbjct: 256 -QQVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYI 314
Query: 1225 -----QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSL 1279
+ G P IL VT+ D+ D + + P Y + + ENV +V +
Sbjct: 315 LQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF----GYNVSVNENVGGGTAVVQV 370
Query: 1280 NLTEH--YENFKMRYYILNENDTDIRRTFVIDPRNGTLYL-VRSPDREVKDTYEVIVRAE 1336
T+ N + YYI E + D+ TF +D +G + PDRE + Y ++ E
Sbjct: 371 RATDRDIGINSVLSYYI-TEGNKDM--TFRMDRISGEIATRPAPPDRERQSFYHLVATVE 427
Score = 63.3 bits (147), Expect = 6e-09
Identities = 51/181 (28%), Positives = 81/181 (44%), Gaps = 15/181 (8%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D+D G G + Y ++SG + K F +D G + LD + + ++++ V
Sbjct: 52 VQATDRDSGDGGLVNYRILSGAEGK-FEIDESTGLIITVNYLDYETK-----TSYMMNVS 105
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A+ P V I LL+ D +F Y +I+ENL G +++V A D
Sbjct: 106 ATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--N 163
Query: 338 NGEFTYQLD-----DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVG 392
+ TY+ D K F ID +G +TV Q ++DRE + V A + P V
Sbjct: 164 LNQITYRFDAYTSTQAKALFKIDAITGVITV--QGLVDREKGDFYTLTVVADDGGPKVDS 221
Query: 393 T 393
T
Sbjct: 222 T 222
Score = 62.5 bits (145), Expect = 1e-08
Identities = 34/106 (32%), Positives = 55/106 (51%), Gaps = 5/106 (4%)
Query: 765 ISGAGIYQVTIYIEDENDNPPVFEHATYEGF-IMENSKIGTEIKMDNIIKATDADEGTNA 823
+ G V +Y+ED ND PVF Y + E + IGT + +++ATD D G
Sbjct: 7 VCGTASSMVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSV---IVVQATDRDSGDGG 63
Query: 824 LFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARD 869
L Y + + F++DE+TG++ + + LD E K Y +++ A D
Sbjct: 64 LVNYRILSGAEGKFEIDESTGLIITV-NYLDYETKTSYMMNVSATD 108
Score = 62.5 bits (145), Expect = 1e-08
Identities = 64/216 (29%), Positives = 95/216 (43%), Gaps = 19/216 (8%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I EN+ +GT I+++ A +D+ LN QI Y F++ + + K F I+ G
Sbjct: 143 ILENLALGTEIVRVQAYSIDN-LN-QITYRFDAYT----------STQAKALFKIDAITG 190
Query: 1000 HVIVARSLPPESE--FRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYN-FNVEE 1056
+ V + E + L + A DGG D+ V + V D ND+ P F T + ++ E
Sbjct: 191 VITVQGLVDREKGDFYTLTVVADDGGPKVDSTVVYITVLDENDNSPRFDFTSDSAVSIPE 250
Query: 1057 AQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEI---SPLTGVLSVNGELDRETE 1113
+ + V A D D G N + + + + FEI + G + V LDRE
Sbjct: 251 DCPVGQQVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREEL 310
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
D YIL VVA D G D+NDN P
Sbjct: 311 DHYILQVVASDRG-TPPRKKDHILQVTILDINDNPP 345
Score = 54.0 bits (124), Expect = 4e-06
Identities = 36/104 (34%), Positives = 52/104 (50%), Gaps = 4/104 (3%)
Query: 287 TAQARVEIELLDLNDNLPEFEVDFYN-ISIVENLPNGFSVLQVMATDKDQGENGEFTYQ- 344
TA + V + + D+ND P F Y+ + + E G SV+ V ATD+D G+ G Y+
Sbjct: 10 TASSMVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRI 69
Query: 345 LDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNP 388
L +G F ID +G + N LD E +S M V A + P
Sbjct: 70 LSGAEGKFEIDESTGLIITVN--YLDYETKTSYMMNVSATDQAP 111
Score = 49.6 bits (113), Expect = 8e-05
Identities = 33/95 (34%), Positives = 47/95 (49%), Gaps = 2/95 (2%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYN-FNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
V V+V+D+ND PVF + Y+ + E + V ATD D G + Y I S
Sbjct: 15 VIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRIL-SGA 73
Query: 1090 DLPFEISPLTGVLSVNGELDRETEDKYILTVVARD 1124
+ FEI TG++ LD ET+ Y++ V A D
Sbjct: 74 EGKFEIDESTGLIITVNYLDYETKTSYMMNVSATD 108
Score = 48.0 bits (109), Expect = 3e-04
Identities = 40/129 (31%), Positives = 62/129 (48%), Gaps = 11/129 (8%)
Query: 230 TLRYELISGNDRK-LFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTA 288
T R++ + K LF +D++ G + ++ +D + + + + L V A P K
Sbjct: 168 TYRFDAYTSTQAKALFKIDAITGVITVQGLVDRE-----KGDFYTLTVVADD-GGP-KVD 220
Query: 289 QARVEIELLDLNDNLPEFEVDFYN-ISIVENLPNGFSVLQVMATDKDQGENGEFTYQL-- 345
V I +LD NDN P F+ + +SI E+ P G V V A D D G NG+ + L
Sbjct: 221 STVVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQQVATVKAWDPDAGSNGQVVFSLAS 280
Query: 346 DDPKGAFSI 354
+ GAF I
Sbjct: 281 GNIAGAFEI 289
>AF217747-1|AAK51615.1| 797|Homo sapiens protocadherin-beta11
protein.
Length = 797
Score = 103 bits (246), Expect = 7e-21
Identities = 129/528 (24%), Positives = 219/528 (41%), Gaps = 59/528 (11%)
Query: 904 IHRETKLNGTAGFTIIEVKPK--NKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSG 961
+H + + F IE++ + N + + L IPEN P+G + +A DLD G
Sbjct: 104 LHLQVLMQNPTQFLQIELQVRDINDHSPIFSEKQMLLEIPENSPVGAVFLLESAKDLDVG 163
Query: 962 LNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISA 1019
+N Y + P S R N ++ +++ ++L E E +SA
Sbjct: 164 INAVKSYTIS-----PNSHFHIKM----RVIPDNRKYPELVLDKALDYEELPELSFILSA 214
Query: 1020 LDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQN 1077
LDGG+ + VRV V D+ND+ P F++ +Y + E ++ V A D D G N
Sbjct: 215 LDGGSPPRSGTALVRVVVVDINDNSPEFEQAFYEVKIRENSILGSLILIVSAWDLDSGTN 274
Query: 1078 ANLTYFIQPSDTDL--PFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXX 1135
+ Y + D+ FEI+ +G +++ LD ET + Y + + A D G
Sbjct: 275 GEICYTFSHASEDIRKTFEINQKSGEITLRAPLDFETIESYSIIIQATDGG---GLFGKS 331
Query: 1136 XXXXXXXDVNDNSPKF--YAFDELLEWKHPEADEL--SNHNFESVMMIPVYKATIEENAP 1191
DVNDN+P+ + + PE + S + +S + +I E+ P
Sbjct: 332 TVIIHVIDVNDNAPEITVSSITSPIPENTPETVVMVFSIQDIDSGDNGRIV-CSIPEDLP 390
Query: 1192 --IGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEV 1249
+ ++V + +T+ + Y++ +LG+P L + V V+DV D
Sbjct: 391 FVLKSSVENYYTLETERPLDRESTAEYNI--TITVTDLGIPRLKTEHNTTVLVSDVND-- 446
Query: 1250 EMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV 1307
+ P F Y L + EN + + + S++ T+ N ++ Y +L D + +
Sbjct: 447 ---NAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVNYSLLPPQDLHLPLASL 503
Query: 1308 --IDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVK 1365
I+ NG L+ +RS D E ++ V A R P + +
Sbjct: 504 VSINTDNGHLFALRSLDYEALQAFDFRVGAT----DRGSPAL-------------SSEAL 546
Query: 1366 VVVRIKDVNDNSP----KFTNGNRPLVTAIPTTAPFGYQVMQLKGAIG 1409
V V + D NDNSP NG+ P +P A GY V ++ G
Sbjct: 547 VRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDG 594
Score = 103 bits (246), Expect = 7e-21
Identities = 111/465 (23%), Positives = 190/465 (40%), Gaps = 36/465 (7%)
Query: 442 FVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQR 501
F+ +E+ + D ND++P+F + + N+ VG V A D D+G N + Y +
Sbjct: 116 FLQIELQVRDINDHSPIFSEKQML-LEIPENSPVGAVFLLESAKDLDVGINAVKSYTISP 174
Query: 502 TSNLTITSPFKINPNTGTVSVAESPILEGRH----ALFVEASDQPANPSERRYSLAVVTI 557
S+ I I N + L+ + + A D + P + VV +
Sbjct: 175 NSHFHIKMRV-IPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVVVV 233
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYE 615
++ + P+F A YE + N +G+ + + D+ ++ Y H E
Sbjct: 234 DINDNS-------PEFEQAFYEVKIRENSILGSLILIVSAWDLDSGTNGEICYTFSHASE 286
Query: 616 E-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERG 674
+ F + ++SG IT+ L Y + + L + +HV+DVND
Sbjct: 287 DIRKTFEINQKSGEITLRAPLDFETIESYSI-IIQATDGGGLFGKSTVIIHVIDVNDNAP 345
Query: 675 VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAE 734
+ S I + EN+ + +F ++ I G + I ++
Sbjct: 346 EI---TVSSITSPIPENTPETVV-MVF--SIQDIDSGDNGRIVCSIPEDLPFVLKSSVEN 399
Query: 735 DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEG 794
T+ T++PLDRE Y +T+ + G+ + T+ + D NDN P F +Y
Sbjct: 400 YYTLETERPLDRESTAEYNITITVT-DLGIPRLKTEHNTTVLVSDVNDNAPTFTQTSYTL 458
Query: 795 FIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDENTGVVKF 848
F+ EN+ I + ATD D GTNA Y+L + ++ + G + F
Sbjct: 459 FVRENNSPALHI---GSVSATDRDSGTNAQVNYSLLPPQDLHLPLASLVSINTDNGHL-F 514
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
SLD E + + A D G LSSEA + +++ D NDN P
Sbjct: 515 ALRSLDYEALQAFDFRVGATDRGSPALSSEALVRVLVLDANDNSP 559
Score = 75.4 bits (177), Expect = 1e-12
Identities = 85/325 (26%), Positives = 140/325 (43%), Gaps = 31/325 (9%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPI--GPSLTIPLTVPRGLT 139
+V +++ DVNDN P + + E TP +F I I G + I ++P L
Sbjct: 332 TVIIHVIDVNDNAPEITVSSITSPIPENTPE-TVVMVFSIQDIDSGDNGRIVCSIPEDLP 390
Query: 140 IF-----KDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
++ + ++P S Y+I ++ D G L++ H +L+ V D
Sbjct: 391 FVLKSSVENYYTLETERPLDRESTAEYNITITVTDLGIPRLKTEHNTTVLVSDVNDNAPT 450
Query: 194 DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLFSLDS 248
+ + + + L + A D+D G A + Y L+ D L S+++
Sbjct: 451 FTQTSYTLFV--RENNSPALHIGSVSATDRDSGTNAQVNYSLLPPQDLHLPLASLVSINT 508
Query: 249 VNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEV 308
NG LF + LD +A LQA F +V A+ +P +++A V + +LD NDN P
Sbjct: 509 DNGHLFALRSLDYEA---LQA--FDFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLY 563
Query: 309 DFYNISI--VENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGW 360
N S E +P G+ V +V+A D D G+N +YQL G F + +G
Sbjct: 564 PLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG- 622
Query: 361 LTVRNQTVLDREAHSSLRMKVYAKE 385
VR +L + R+ V K+
Sbjct: 623 -EVRTARLLSERDAAKHRLVVLVKD 646
Score = 74.9 bits (176), Expect = 2e-12
Identities = 62/236 (26%), Positives = 111/236 (47%), Gaps = 17/236 (7%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLIAN 722
+ V D+ND + + ++ + ENS +G +F + G V+ + I+
Sbjct: 121 LQVRDINDHSPIF---SEKQMLLEIPENSP---VGAVFLLESAKDLDVGINAVKSYTISP 174
Query: 723 QQDVTDDIAIAEDGTIFTQKPLDR--EKRDVYRMT-VIAEFNKGVISGAGIYQVTIYIED 779
+ + D + + LD+ + ++ ++ +++ + G +G V + + D
Sbjct: 175 NSHFHIKMRVIPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVVVVD 234
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM--- 836
NDN P FE A YE I ENS +G+ I I+ A D D GTN YT +++
Sbjct: 235 INDNSPEFEQAFYEVKIRENSILGSLIL---IVSAWDLDSGTNGEICYTFSHASEDIRKT 291
Query: 837 FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
F++++ +G + + LD E Y + + A D GGL ++ +II + D NDN PE
Sbjct: 292 FEINQKSGEIT-LRAPLDFETIESYSIIIQATDGGGLFGKSTVIIHVIDVNDNAPE 346
Score = 68.1 bits (159), Expect = 2e-10
Identities = 57/175 (32%), Positives = 86/175 (49%), Gaps = 17/175 (9%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGS-----LFLEKELDLDAEHNLQANTFVL 274
A D D+G+ A Y IS N + + + L L+K LD + L +F+L
Sbjct: 157 AKDLDVGINAVKSYT-ISPNSHFHIKMRVIPDNRKYPELVLDKALDYE---ELPELSFIL 212
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
A +P ++ A V + ++D+NDN PEFE FY + I EN G +L V A D D
Sbjct: 213 S--ALDGGSPPRSGTALVRVVVVDINDNSPEFEQAFYEVKIRENSILGSLILIVSAWDLD 270
Query: 335 QGENGE----FTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
G NGE F++ +D + F I+ +SG +T+R LD E S + + A +
Sbjct: 271 SGTNGEICYTFSHASEDIRKTFEINQKSGEITLR--APLDFETIESYSIIIQATD 323
Score = 62.1 bits (144), Expect = 1e-08
Identities = 64/220 (29%), Positives = 89/220 (40%), Gaps = 18/220 (8%)
Query: 917 TIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYI 976
T + V N A Q + EN I ++A D DSG N Q+ Y +
Sbjct: 437 TTVLVSDVNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVNYSL-----L 491
Query: 977 PPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVR 1032
PP L L + IN +GH+ RSL E+ F + A D G+ L+ VR
Sbjct: 492 PPQDLH---LPLASLVSINTDNGHLFALRSLDYEALQAFDFRVGATDRGSPALSSEALVR 548
Query: 1033 VFVKDVNDHFPVFKKTWYNFN------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQP 1086
V V D ND+ P N + V A ++ KV A D D GQNA L+Y +
Sbjct: 549 VLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLK 608
Query: 1087 SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+ F + G + L K+ L V+ +DNG
Sbjct: 609 ATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNG 648
Score = 50.8 bits (116), Expect = 4e-05
Identities = 41/138 (29%), Positives = 64/138 (46%), Gaps = 9/138 (6%)
Query: 772 QVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG 831
Q+ + + D ND+ P+F I ENS +G +++ A D D G NA+ YT+
Sbjct: 118 QIELQVRDINDHSPIFSEKQMLLEIPENSPVGAVFLLES---AKDLDVGINAVKSYTISP 174
Query: 832 EGK---EMFDVDENTGVVKFIGD-SLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGD 885
+M + +N + + D +LD E+ L A D G S A + +++ D
Sbjct: 175 NSHFHIKMRVIPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVVVVD 234
Query: 886 ENDNKPEFNQIEENSKVR 903
NDN PEF Q K+R
Sbjct: 235 INDNSPEFEQAFYEVKIR 252
Score = 48.4 bits (110), Expect = 2e-04
Identities = 57/252 (22%), Positives = 98/252 (38%), Gaps = 16/252 (6%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIAN- 722
V VVD+ND + + ++ENS ++ I + + G + + ++
Sbjct: 230 VVVVDINDNSPEFEQAFYE---VKIRENSILGSL--ILIVSAWDLDSGTNGEICYTFSHA 284
Query: 723 QQDVTDDIAIAE-DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
+D+ I + G I + PLD E + Y + + A G+ G V I++ D N
Sbjct: 285 SEDIRKTFEINQKSGEITLRAPLDFETIESYSIIIQATDGGGLF---GKSTVIIHVIDVN 341
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDE 841
DN P ++ I EN T + + D D G N + ++ + +
Sbjct: 342 DNAPEITVSSITSPIPEN----TPETVVMVFSIQDIDSGDNGRIVCSIPEDLPFVLKSSV 397
Query: 842 NTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
LDRE Y +++ D G L +E +++ D NDN P F Q
Sbjct: 398 ENYYTLETERPLDRESTAEYNITITVTDLGIPRLKTEHNTTVLVSDVNDNAPTFTQTSYT 457
Query: 900 SKVRIHRETKLN 911
VR + L+
Sbjct: 458 LFVRENNSPALH 469
Score = 47.6 bits (108), Expect = 3e-04
Identities = 67/317 (21%), Positives = 122/317 (38%), Gaps = 26/317 (8%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP---IGPSLTIPLTV-P 135
+L + + + D+ND+ PIF + + + E +P G F+ A +G + T+ P
Sbjct: 116 FLQIELQVRDINDHSPIFSEKQMLLEIPENSPVGA-VFLLESAKDLDVGINAVKSYTISP 174
Query: 136 RG-----LTIFKDIRAFDR---DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKV 187
+ + D R + DK S + DG S V ++ V
Sbjct: 175 NSHFHIKMRVIPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVV--V 232
Query: 188 LDYDAGDKEFQLVIMASGKRIHKEI-LFPEPIHAIDQDLGVGATLRYELISGND--RKLF 244
+D + EF+ R + + + A D D G + Y ++ RK F
Sbjct: 233 VDINDNSPEFEQAFYEVKIRENSILGSLILIVSAWDLDSGTNGEICYTFSHASEDIRKTF 292
Query: 245 SLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLP 304
++ +G + L LD + ++ + +QA+ ++ V I ++D+NDN P
Sbjct: 293 EINQKSGEITLRAPLDFET-----IESYSIIIQATDGGGLF--GKSTVIIHVIDVNDNAP 345
Query: 305 EFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVR 364
E V I EN P V+ D D G+NG + + + T+
Sbjct: 346 EITVSSITSPIPENTPETV-VMVFSIQDIDSGDNGRIVCSIPEDLPFVLKSSVENYYTLE 404
Query: 365 NQTVLDREAHSSLRMKV 381
+ LDRE+ + + +
Sbjct: 405 TERPLDRESTAEYNITI 421
Score = 44.0 bits (99), Expect = 0.004
Identities = 37/123 (30%), Positives = 56/123 (45%), Gaps = 5/123 (4%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
++S + ++ LD G L L + LD + E VL +Q + NP + Q +E+
Sbjct: 66 VVSNDKKQRLQLDINTGDLLLSETLDRE-ELCGSIEPCVLHLQVL-MQNPTQFLQ--IEL 121
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
++ D+ND+ P F + I EN P G L A D D G N +Y + P F I
Sbjct: 122 QVRDINDHSPIFSEKQMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTI-SPNSHFHI 180
Query: 355 DPR 357
R
Sbjct: 181 KMR 183
Score = 39.9 bits (89), Expect = 0.069
Identities = 38/126 (30%), Positives = 54/126 (42%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 541 LSSEALVRVLVLDANDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 599
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + + + N T + S +H L V D P +L
Sbjct: 600 AWLSYQLLKATEPGLFGVWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 658
Query: 553 AVVTIE 558
V+ ++
Sbjct: 659 QVLLVD 664
>AF152490-1|AAD43751.1| 797|Homo sapiens protocadherin beta 11
protein.
Length = 797
Score = 103 bits (246), Expect = 7e-21
Identities = 129/528 (24%), Positives = 219/528 (41%), Gaps = 59/528 (11%)
Query: 904 IHRETKLNGTAGFTIIEVKPK--NKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSG 961
+H + + F IE++ + N + + L IPEN P+G + +A DLD G
Sbjct: 104 LHLQVLMQNPTQFLQIELQVRDINDHSPIFSEKQMLLEIPENSPVGAVFLLESAKDLDVG 163
Query: 962 LNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISA 1019
+N Y + P S R N ++ +++ ++L E E +SA
Sbjct: 164 INAVKSYTIS-----PNSHFHIKM----RVIPDNRKYPELVLDKALDYEELPELSFILSA 214
Query: 1020 LDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQN 1077
LDGG+ + VRV V D+ND+ P F++ +Y + E ++ V A D D G N
Sbjct: 215 LDGGSPPRSGTALVRVVVVDINDNSPEFEQAFYEVKIRENSILGSLILIVSAWDLDSGTN 274
Query: 1078 ANLTYFIQPSDTDL--PFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXX 1135
+ Y + D+ FEI+ +G +++ LD ET + Y + + A D G
Sbjct: 275 GEICYTFSHASEDIRKTFEINQKSGEITLRAPLDFETIESYSIIIQATDGG---GLFGKS 331
Query: 1136 XXXXXXXDVNDNSPKF--YAFDELLEWKHPEADEL--SNHNFESVMMIPVYKATIEENAP 1191
DVNDN+P+ + + PE + S + +S + +I E+ P
Sbjct: 332 TVIIHVIDVNDNAPEITVSSITSPIPENTPETVVMVFSIQDIDSGDNGRIV-CSIPEDLP 390
Query: 1192 --IGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEV 1249
+ ++V + +T+ + Y++ +LG+P L + V V+DV D
Sbjct: 391 FVLKSSVENYYTLETERPLDRESTAEYNI--TITVTDLGIPRLKTEHNTTVLVSDVND-- 446
Query: 1250 EMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV 1307
+ P F Y L + EN + + + S++ T+ N ++ Y +L D + +
Sbjct: 447 ---NAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVNYSLLPPQDLHLPLASL 503
Query: 1308 --IDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVK 1365
I+ NG L+ +RS D E ++ V A R P + +
Sbjct: 504 VSINTDNGHLFALRSLDYEALQAFDFRVGAT----DRGSPAL-------------SSEAL 546
Query: 1366 VVVRIKDVNDNSP----KFTNGNRPLVTAIPTTAPFGYQVMQLKGAIG 1409
V V + D NDNSP NG+ P +P A GY V ++ G
Sbjct: 547 VRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDG 594
Score = 103 bits (246), Expect = 7e-21
Identities = 111/465 (23%), Positives = 190/465 (40%), Gaps = 36/465 (7%)
Query: 442 FVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQR 501
F+ +E+ + D ND++P+F + + N+ VG V A D D+G N + Y +
Sbjct: 116 FLQIELQVRDINDHSPIFSEKQML-LEIPENSPVGAVFLLESAKDLDVGINAVKSYTISP 174
Query: 502 TSNLTITSPFKINPNTGTVSVAESPILEGRH----ALFVEASDQPANPSERRYSLAVVTI 557
S+ I I N + L+ + + A D + P + VV +
Sbjct: 175 NSHFHIKMRV-IPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVVVV 233
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRV--NDAFEQNDVSYDLLHGYE 615
++ + P+F A YE + N +G+ + + D+ ++ Y H E
Sbjct: 234 DINDNS-------PEFEQAFYEVKIRENSILGSLILIVSAWDLDSGTNGEICYTFSHASE 286
Query: 616 E-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERG 674
+ F + ++SG IT+ L Y + + L + +HV+DVND
Sbjct: 287 DIRKTFEINQKSGEITLRAPLDFETIESYSI-IIQATDGGGLFGKSTVIIHVIDVNDNAP 345
Query: 675 VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAE 734
+ S I + EN+ + +F ++ I G + I ++
Sbjct: 346 EI---TVSSITSPIPENTPETVV-MVF--SIQDIDSGDNGRIVCSIPEDLPFVLKSSVEN 399
Query: 735 DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEG 794
T+ T++PLDRE Y +T+ + G+ + T+ + D NDN P F +Y
Sbjct: 400 YYTLETERPLDRESTAEYNITITVT-DLGIPRLKTEHNTTVLVSDVNDNAPTFTQTSYTL 458
Query: 795 FIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDENTGVVKF 848
F+ EN+ I + ATD D GTNA Y+L + ++ + G + F
Sbjct: 459 FVRENNSPALHI---GSVSATDRDSGTNAQVNYSLLPPQDLHLPLASLVSINTDNGHL-F 514
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
SLD E + + A D G LSSEA + +++ D NDN P
Sbjct: 515 ALRSLDYEALQAFDFRVGATDRGSPALSSEALVRVLVLDANDNSP 559
Score = 75.4 bits (177), Expect = 1e-12
Identities = 85/325 (26%), Positives = 140/325 (43%), Gaps = 31/325 (9%)
Query: 82 SVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPI--GPSLTIPLTVPRGLT 139
+V +++ DVNDN P + + E TP +F I I G + I ++P L
Sbjct: 332 TVIIHVIDVNDNAPEITVSSITSPIPENTPE-TVVMVFSIQDIDSGDNGRIVCSIPEDLP 390
Query: 140 IF-----KDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAG 193
++ + ++P S Y+I ++ D G L++ H +L+ V D
Sbjct: 391 FVLKSSVENYYTLETERPLDRESTAEYNITITVTDLGIPRLKTEHNTTVLVSDVNDNAPT 450
Query: 194 DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKLFSLDS 248
+ + + + L + A D+D G A + Y L+ D L S+++
Sbjct: 451 FTQTSYTLFV--RENNSPALHIGSVSATDRDSGTNAQVNYSLLPPQDLHLPLASLVSINT 508
Query: 249 VNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEV 308
NG LF + LD +A LQA F +V A+ +P +++A V + +LD NDN P
Sbjct: 509 DNGHLFALRSLDYEA---LQA--FDFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLY 563
Query: 309 DFYNISI--VENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGW 360
N S E +P G+ V +V+A D D G+N +YQL G F + +G
Sbjct: 564 PLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG- 622
Query: 361 LTVRNQTVLDREAHSSLRMKVYAKE 385
VR +L + R+ V K+
Sbjct: 623 -EVRTARLLSERDAAKHRLVVLVKD 646
Score = 74.9 bits (176), Expect = 2e-12
Identities = 62/236 (26%), Positives = 111/236 (47%), Gaps = 17/236 (7%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLIAN 722
+ V D+ND + + ++ + ENS +G +F + G V+ + I+
Sbjct: 121 LQVRDINDHSPIF---SEKQMLLEIPENSP---VGAVFLLESAKDLDVGINAVKSYTISP 174
Query: 723 QQDVTDDIAIAEDGTIFTQKPLDR--EKRDVYRMT-VIAEFNKGVISGAGIYQVTIYIED 779
+ + D + + LD+ + ++ ++ +++ + G +G V + + D
Sbjct: 175 NSHFHIKMRVIPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVVVVD 234
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM--- 836
NDN P FE A YE I ENS +G+ I I+ A D D GTN YT +++
Sbjct: 235 INDNSPEFEQAFYEVKIRENSILGSLIL---IVSAWDLDSGTNGEICYTFSHASEDIRKT 291
Query: 837 FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
F++++ +G + + LD E Y + + A D GGL ++ +II + D NDN PE
Sbjct: 292 FEINQKSGEIT-LRAPLDFETIESYSIIIQATDGGGLFGKSTVIIHVIDVNDNAPE 346
Score = 68.1 bits (159), Expect = 2e-10
Identities = 57/175 (32%), Positives = 86/175 (49%), Gaps = 17/175 (9%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGS-----LFLEKELDLDAEHNLQANTFVL 274
A D D+G+ A Y IS N + + + L L+K LD + L +F+L
Sbjct: 157 AKDLDVGINAVKSYT-ISPNSHFHIKMRVIPDNRKYPELVLDKALDYE---ELPELSFIL 212
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
A +P ++ A V + ++D+NDN PEFE FY + I EN G +L V A D D
Sbjct: 213 S--ALDGGSPPRSGTALVRVVVVDINDNSPEFEQAFYEVKIRENSILGSLILIVSAWDLD 270
Query: 335 QGENGE----FTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
G NGE F++ +D + F I+ +SG +T+R LD E S + + A +
Sbjct: 271 SGTNGEICYTFSHASEDIRKTFEINQKSGEITLR--APLDFETIESYSIIIQATD 323
Score = 62.1 bits (144), Expect = 1e-08
Identities = 64/220 (29%), Positives = 89/220 (40%), Gaps = 18/220 (8%)
Query: 917 TIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYI 976
T + V N A Q + EN I ++A D DSG N Q+ Y +
Sbjct: 437 TTVLVSDVNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVNYSL-----L 491
Query: 977 PPSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVR 1032
PP L L + IN +GH+ RSL E+ F + A D G+ L+ VR
Sbjct: 492 PPQDLH---LPLASLVSINTDNGHLFALRSLDYEALQAFDFRVGATDRGSPALSSEALVR 548
Query: 1033 VFVKDVNDHFPVFKKTWYNFN------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQP 1086
V V D ND+ P N + V A ++ KV A D D GQNA L+Y +
Sbjct: 549 VLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLK 608
Query: 1087 SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+ F + G + L K+ L V+ +DNG
Sbjct: 609 ATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNG 648
Score = 50.8 bits (116), Expect = 4e-05
Identities = 41/138 (29%), Positives = 64/138 (46%), Gaps = 9/138 (6%)
Query: 772 QVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG 831
Q+ + + D ND+ P+F I ENS +G +++ A D D G NA+ YT+
Sbjct: 118 QIELQVRDINDHSPIFSEKQMLLEIPENSPVGAVFLLES---AKDLDVGINAVKSYTISP 174
Query: 832 EGK---EMFDVDENTGVVKFIGD-SLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGD 885
+M + +N + + D +LD E+ L A D G S A + +++ D
Sbjct: 175 NSHFHIKMRVIPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVVVVD 234
Query: 886 ENDNKPEFNQIEENSKVR 903
NDN PEF Q K+R
Sbjct: 235 INDNSPEFEQAFYEVKIR 252
Score = 48.4 bits (110), Expect = 2e-04
Identities = 57/252 (22%), Positives = 98/252 (38%), Gaps = 16/252 (6%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIAN- 722
V VVD+ND + + ++ENS ++ I + + G + + ++
Sbjct: 230 VVVVDINDNSPEFEQAFYE---VKIRENSILGSL--ILIVSAWDLDSGTNGEICYTFSHA 284
Query: 723 QQDVTDDIAIAE-DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEN 781
+D+ I + G I + PLD E + Y + + A G+ G V I++ D N
Sbjct: 285 SEDIRKTFEINQKSGEITLRAPLDFETIESYSIIIQATDGGGLF---GKSTVIIHVIDVN 341
Query: 782 DNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDE 841
DN P ++ I EN T + + D D G N + ++ + +
Sbjct: 342 DNAPEITVSSITSPIPEN----TPETVVMVFSIQDIDSGDNGRIVCSIPEDLPFVLKSSV 397
Query: 842 NTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIEEN 899
LDRE Y +++ D G L +E +++ D NDN P F Q
Sbjct: 398 ENYYTLETERPLDRESTAEYNITITVTDLGIPRLKTEHNTTVLVSDVNDNAPTFTQTSYT 457
Query: 900 SKVRIHRETKLN 911
VR + L+
Sbjct: 458 LFVRENNSPALH 469
Score = 47.6 bits (108), Expect = 3e-04
Identities = 67/317 (21%), Positives = 122/317 (38%), Gaps = 26/317 (8%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP---IGPSLTIPLTV-P 135
+L + + + D+ND+ PIF + + + E +P G F+ A +G + T+ P
Sbjct: 116 FLQIELQVRDINDHSPIFSEKQMLLEIPENSPVGA-VFLLESAKDLDVGINAVKSYTISP 174
Query: 136 RG-----LTIFKDIRAFDR---DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKV 187
+ + D R + DK S + DG S V ++ V
Sbjct: 175 NSHFHIKMRVIPDNRKYPELVLDKALDYEELPELSFILSALDGGSPPRSGTALVRVV--V 232
Query: 188 LDYDAGDKEFQLVIMASGKRIHKEI-LFPEPIHAIDQDLGVGATLRYELISGND--RKLF 244
+D + EF+ R + + + A D D G + Y ++ RK F
Sbjct: 233 VDINDNSPEFEQAFYEVKIRENSILGSLILIVSAWDLDSGTNGEICYTFSHASEDIRKTF 292
Query: 245 SLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLP 304
++ +G + L LD + ++ + +QA+ ++ V I ++D+NDN P
Sbjct: 293 EINQKSGEITLRAPLDFET-----IESYSIIIQATDGGGLF--GKSTVIIHVIDVNDNAP 345
Query: 305 EFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVR 364
E V I EN P V+ D D G+NG + + + T+
Sbjct: 346 EITVSSITSPIPENTPETV-VMVFSIQDIDSGDNGRIVCSIPEDLPFVLKSSVENYYTLE 404
Query: 365 NQTVLDREAHSSLRMKV 381
+ LDRE+ + + +
Sbjct: 405 TERPLDRESTAEYNITI 421
Score = 44.0 bits (99), Expect = 0.004
Identities = 37/123 (30%), Positives = 56/123 (45%), Gaps = 5/123 (4%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
++S + ++ LD G L L + LD + E VL +Q + NP + Q +E+
Sbjct: 66 VVSNDKKQRLQLDINTGDLLLSETLDRE-ELCGSIEPCVLHLQVL-MQNPTQFLQ--IEL 121
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
++ D+ND+ P F + I EN P G L A D D G N +Y + P F I
Sbjct: 122 QVRDINDHSPIFSEKQMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTI-SPNSHFHI 180
Query: 355 DPR 357
R
Sbjct: 181 KMR 183
Score = 39.9 bits (89), Expect = 0.069
Identities = 38/126 (30%), Positives = 54/126 (42%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 541 LSSEALVRVLVLDANDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 599
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + + + N T + S +H L V D P +L
Sbjct: 600 AWLSYQLLKATEPGLFGVWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPRSATATL 658
Query: 553 AVVTIE 558
V+ ++
Sbjct: 659 QVLLVD 664
>AF152482-1|AAD43743.1| 798|Homo sapiens protocadherin alpha 4 short
form protein protein.
Length = 798
Score = 103 bits (246), Expect = 7e-21
Identities = 115/427 (26%), Positives = 183/427 (42%), Gaps = 60/427 (14%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAG--IYQVTIYIEDENDNPPVFEHAT 791
++G +F +DRE ++ R + + VI ++ V + + D NDNPPVF
Sbjct: 80 QNGILFVNSRIDRE--ELCRRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPVFPATQ 137
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD 851
I E+ + + ++ A+DAD G NAL Y L E F +++
Sbjct: 138 KNLSIAESRPLDSRFPLEG---ASDADIGENALLTYRL--SPNEYFSLEKPP-------- 184
Query: 852 SLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
+ +++ L L+ R + E+ +++ + KPE L
Sbjct: 185 ----DDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPE-----------------LT 223
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
GT +I V N A D+ + EN+P GT +IKLNA DLD GLNG I Y F+
Sbjct: 224 GTVQL-LITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFS 282
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN--LND 1027
++ I P+ VK F I+ G +IV + E + + + +D G L+
Sbjct: 283 ND--ISPN--------VKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSG 332
Query: 1028 NISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
+ V V V+D ND+ P + + + E V+ + +D D G N +T +
Sbjct: 333 HCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSL--- 389
Query: 1088 DTDLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDV 1144
+ +PF+ +S S ++ LDRE+ Y L V ARD G DV
Sbjct: 390 TSHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGG-SPSLWATASVSVEVADV 448
Query: 1145 NDNSPKF 1151
NDN+P F
Sbjct: 449 NDNAPAF 455
Score = 88.6 bits (210), Expect = 1e-16
Identities = 111/464 (23%), Positives = 197/464 (42%), Gaps = 35/464 (7%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + +T+LDANDN P F +Y+ + N GT++ K+ A D D G NG ++Y
Sbjct: 221 ELTGTVQLLITVLDANDNAPAF-DRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVY 279
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + S F I+P TG + V E + + VE D+ P V
Sbjct: 280 SFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGH---CRV 336
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+EV + N ++PD + + +GT + I V+D + V+ +
Sbjct: 337 IVEV----EDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSD--KDMGVNGLVTCSLT 390
Query: 616 EGVPF-AVEERSGVITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVND 671
VPF V ++V D L R + Y+ A + +L + +V V DVND
Sbjct: 391 SHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVND 450
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLI----ANQQDVT 727
+ ++ +F VKEN+ IF + V + + ++ ++
Sbjct: 451 NAPAFAQPEYT--VF-VKENNPPGC--HIFTVSAWDADAQENALVSYSLVERRVGERALS 505
Query: 728 DDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
+++ AE G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 506 SYVSVHAESGKVYALQPLDHEELELLQFQVTAR-DAGVPPLGSNVTLQVFVLDENDNAPA 564
Query: 787 FEHATYEGFIMENSK-IGTEIKMDNI---IKATDADEGTNALFMYTL---FGEGKEMFDV 839
G S+ + + + ++ ++A DAD G NA Y L G + F V
Sbjct: 565 LLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRV 624
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMI 883
TG + +LD ++L ++ +D G + A +++
Sbjct: 625 GLYTGEIS-TTRALDETDAPRHRLLVLVKDHGEPALTATATVLV 667
Score = 74.1 bits (174), Expect = 3e-12
Identities = 104/475 (21%), Positives = 180/475 (37%), Gaps = 30/475 (6%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +V+V + D NDN PVF P+ S+ + + + A D D+G
Sbjct: 105 HLEVIVDRPLQVFHVDVEVRDINDNPPVF-PATQKNLSIAESRPLDSRFPLEGASDADIG 163
Query: 491 QNGMVLYDLQRTSNLTITSP--FKINPNTGTVSVAESPILEGRHALFVEASDQPANPSER 548
+N ++ Y L ++ P ++ G + E V + P
Sbjct: 164 ENALLTYRLSPNEYFSLEKPPDDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPE-- 221
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDV 606
T+++ + P F Y+ + NV GT V ++ +D E D+
Sbjct: 222 ----LTGTVQLLITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDI 277
Query: 607 SYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
Y + V F ++ +G I V + Y+ + + L + + V
Sbjct: 278 VYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGI-DKGQLPLSGHCRV 336
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
+V+V D + + ++E++ + + + + NG V + +
Sbjct: 337 -IVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGL--VTCSLTSHV 393
Query: 725 DVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
++ LDRE Y + V A + G S V++ + D NDN
Sbjct: 394 PFKLVSTFKNYYSLVLDSALDRESVSAYELVVTAR-DGGSPSLWATASVSVEVADVNDNA 452
Query: 785 PVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF----GEG--KEMFD 838
P F Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 453 PAFAQPEYTVFVKENNPPGCHIFT---VSAWDADAQENALVSYSLVERRVGERALSSYVS 509
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 510 VHAESGKVYAL-QPLDHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAP 563
Score = 72.9 bits (171), Expect = 8e-12
Identities = 52/157 (33%), Positives = 78/157 (49%), Gaps = 20/157 (12%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDS------VNG-SLFLEKELDLDAEHNLQANTF 272
A D D+G A L Y L + + FSL+ V G L L K LD + +A
Sbjct: 157 ASDADIGENALLTYRL---SPNEYFSLEKPPDDELVKGLGLILRKSLDRE-----EAPEI 208
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
L + A+ P T ++ I +LD NDN P F+ Y + ++EN+PNG V+++ A+D
Sbjct: 209 FLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASD 268
Query: 333 KDQGENGEFTYQLDDP-----KGAFSIDPRSGWLTVR 364
D+G NG+ Y + K F IDP +G + V+
Sbjct: 269 LDEGLNGDIVYSFSNDISPNVKSKFHIDPITGQIIVK 305
Score = 67.3 bits (157), Expect = 4e-10
Identities = 73/290 (25%), Positives = 115/290 (39%), Gaps = 18/290 (6%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L G +++ + + + + D NDN P F T Y V + E P G + +
Sbjct: 212 LTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDE 271
Query: 127 SLTIPLTVPRGLTIFKDIRAFDRDKPNT-----------PNSDVHYSIVSGNDDGHFALE 175
L + I ++++ P T S + IV G D G L
Sbjct: 272 GLNGDIVYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPL- 330
Query: 176 SSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
S H V++ + + + D EF+ + + + + I D+D+GV + L
Sbjct: 331 SGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIAL-ISVSDKDMGVNGLVTCSL 389
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIE 295
S KL S SL L+ LD ++ + + L V A +P A A V +E
Sbjct: 390 TSHVPFKLVSTFKNYYSLVLDSALDRES-----VSAYELVVTARDGGSPSLWATASVSVE 444
Query: 296 LLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+ D+NDN P F Y + + EN P G + V A D D EN +Y L
Sbjct: 445 VADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSL 494
Score = 63.7 bits (148), Expect = 5e-09
Identities = 48/164 (29%), Positives = 75/164 (45%), Gaps = 6/164 (3%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I + +D E+ Y + ++ +KG + +G +V + +ED NDN P E +
Sbjct: 300 GQIIVKGYIDFEESKSYEI-IVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLP 358
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
I E++ +GT I + I +D D G N L +L + +LDR
Sbjct: 359 IREDAPLGTVIAL---ISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSALDR 415
Query: 856 EKKIMYKLSLVARDTGGLS--SEAELIIMIGDENDNKPEFNQIE 897
E Y+L + ARD G S + A + + + D NDN P F Q E
Sbjct: 416 ESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPE 459
Score = 63.3 bits (147), Expect = 6e-09
Identities = 50/172 (29%), Positives = 83/172 (48%), Gaps = 14/172 (8%)
Query: 728 DDIAIAEDGTIFTQKPLDREKR-DVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
DD + G I +K LDRE+ +++ + + K ++G Q+ I + D NDN P
Sbjct: 185 DDELVKGLGLIL-RKSLDREEAPEIFLVLTATDGGKPELTGT--VQLLITVLDANDNAPA 241
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGE----GKEMFDVDEN 842
F+ Y+ ++EN GT + N A+D DEG N +Y+ + K F +D
Sbjct: 242 FDRTIYKVRLLENVPNGTLVIKLN---ASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPI 298
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIGDENDNKPE 892
TG + + +D E+ Y++ + D G L S +I+ + D NDN P+
Sbjct: 299 TGQI-IVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPD 349
Score = 59.7 bits (138), Expect = 8e-08
Identities = 62/221 (28%), Positives = 94/221 (42%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y E +
Sbjct: 443 VEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSL-VERRVGE 501
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVF 1034
LS+ Y ++ G V + L E + ++A D G L N++++VF
Sbjct: 502 RALSS-------YVSVHAESGKVYALQPLDHEELELLQFQVTARDAGVPPLGSNVTLQVF 554
Query: 1035 VKDVNDHFPVF---KKTWYNFNVEE----AQYTRRVLGKVDATDADFGQNANLTYFIQP- 1086
V D ND+ P + V E + V+ KV A DAD G NA L+Y +QP
Sbjct: 555 VLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPG 614
Query: 1087 -SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+PF + TG +S LD ++ L V+ +D+G
Sbjct: 615 TGGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHG 655
Score = 59.3 bits (137), Expect = 1e-07
Identities = 70/245 (28%), Positives = 105/245 (42%), Gaps = 23/245 (9%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
I+EV+ N D++ I E+ P+GT I ++ D D G+NG + S V
Sbjct: 337 IVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHV--- 393
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRV 1033
P KL + K Y+ + ++ +L ES + L ++A DGG+ L SV V
Sbjct: 394 PFKLVST---FKNYYSL-------VLDSALDRESVSAYELVVTARDGGSPSLWATASVSV 443
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTD 1090
V DVND+ P F + Y V+E + V A DAD +NA ++Y + + +
Sbjct: 444 EVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERA 503
Query: 1091 LPFEIS--PLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
L +S +G + LD E + V ARD G D NDN+
Sbjct: 504 LSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDAG-VPPLGSNVTLQVFVLDENDNA 562
Query: 1149 PKFYA 1153
P A
Sbjct: 563 PALLA 567
Score = 47.6 bits (108), Expect = 3e-04
Identities = 52/186 (27%), Positives = 85/186 (45%), Gaps = 18/186 (9%)
Query: 175 ESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVG-ATL-- 231
+ S + +LLL + ++AG+ + + K H + I QDLG+ A L
Sbjct: 9 QESRRLLLLLLLLAAWEAGNGQLHYSVSEEAK--HGTF-----VGRIAQDLGLELAELVP 61
Query: 232 -RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQVQASQLNNPLKTAQ 289
+ + S L ++ NG LF+ +D + A + L+V ++ PL+
Sbjct: 62 RLFRVASKGRGGLLEVNLQNGILFVNSRIDREELCRRSAECSIHLEVI---VDRPLQVFH 118
Query: 290 ARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
V++E+ D+NDN P F N+SI E+ P A+D D GEN TY+L P
Sbjct: 119 --VDVEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRL-SPN 175
Query: 350 GAFSID 355
FS++
Sbjct: 176 EYFSLE 181
Score = 46.0 bits (104), Expect = 0.001
Identities = 32/108 (29%), Positives = 52/108 (48%), Gaps = 7/108 (6%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++TV D D + P F Y++ + ENV ++ LN ++ E
Sbjct: 218 GKPELTGTVQLLITVLDAND-----NAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIV 1333
N + Y N+ +++ F IDP G + + D E +YE+IV
Sbjct: 273 LNGDIVYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIV 320
Score = 43.6 bits (98), Expect = 0.006
Identities = 90/377 (23%), Positives = 147/377 (38%), Gaps = 36/377 (9%)
Query: 44 VDSDSPQNVVKFRLGCDFDEGDDLVRIGAGLNQ----ISAYLSVTVYIEDVNDNVPIFLD 99
+D + Q +VK + DF+E I G+++ +S + V V +ED NDNVP
Sbjct: 295 IDPITGQIIVKGYI--DFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEF 352
Query: 100 TPYHVTVDELTPTGEKAFIFLIAP----IGPSLTIPLT--VPRGL-TIFKDIRAFDRDKP 152
+ + E P G + ++ + +T LT VP L + FK+ + D
Sbjct: 353 KSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSA 412
Query: 153 NTPNSDVHYS-IVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKE 211
S Y +V+ D G +L ++ + + V D + + +
Sbjct: 413 LDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGC 472
Query: 212 ILFPEPIHAIDQDLGVGATLRYELISGN--DRKLFSLDSVN---GSLFLEKELDLDAEHN 266
+F + A D D A + Y L+ +R L S SV+ G ++ + LD +
Sbjct: 473 HIFT--VSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELEL 530
Query: 267 LQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLP--- 320
LQ QV A P + +++ +LD NDN P ++ E +P
Sbjct: 531 LQ-----FQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSV 585
Query: 321 -NGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLT--VRNQTVLDREAHSSL 377
G V +V A D D G N +Y+L G I R G T + LD
Sbjct: 586 GVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAPRH 645
Query: 378 RMKVYAKE-TNPSVVGT 393
R+ V K+ P++ T
Sbjct: 646 RLLVLVKDHGEPALTAT 662
>AF152312-1|AAD43706.1| 947|Homo sapiens protocadherin alpha 4
protein.
Length = 947
Score = 103 bits (246), Expect = 7e-21
Identities = 115/427 (26%), Positives = 183/427 (42%), Gaps = 60/427 (14%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAG--IYQVTIYIEDENDNPPVFEHAT 791
++G +F +DRE ++ R + + VI ++ V + + D NDNPPVF
Sbjct: 80 QNGILFVNSRIDRE--ELCRRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPVFPATQ 137
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD 851
I E+ + + ++ A+DAD G NAL Y L E F +++
Sbjct: 138 KNLSIAESRPLDSRFPLEG---ASDADIGENALLTYRL--SPNEYFSLEKPP-------- 184
Query: 852 SLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
+ +++ L L+ R + E+ +++ + KPE L
Sbjct: 185 ----DDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPE-----------------LT 223
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
GT +I V N A D+ + EN+P GT +IKLNA DLD GLNG I Y F+
Sbjct: 224 GTVQL-LITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFS 282
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN--LND 1027
++ I P+ VK F I+ G +IV + E + + + +D G L+
Sbjct: 283 ND--ISPN--------VKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSG 332
Query: 1028 NISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
+ V V V+D ND+ P + + + E V+ + +D D G N +T +
Sbjct: 333 HCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSL--- 389
Query: 1088 DTDLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDV 1144
+ +PF+ +S S ++ LDRE+ Y L V ARD G DV
Sbjct: 390 TSHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGG-SPSLWATASVSVEVADV 448
Query: 1145 NDNSPKF 1151
NDN+P F
Sbjct: 449 NDNAPAF 455
Score = 88.6 bits (210), Expect = 1e-16
Identities = 111/464 (23%), Positives = 197/464 (42%), Gaps = 35/464 (7%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + +T+LDANDN P F +Y+ + N GT++ K+ A D D G NG ++Y
Sbjct: 221 ELTGTVQLLITVLDANDNAPAF-DRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVY 279
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + S F I+P TG + V E + + VE D+ P V
Sbjct: 280 SFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGH---CRV 336
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+EV + N ++PD + + +GT + I V+D + V+ +
Sbjct: 337 IVEV----EDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSD--KDMGVNGLVTCSLT 390
Query: 616 EGVPF-AVEERSGVITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVND 671
VPF V ++V D L R + Y+ A + +L + +V V DVND
Sbjct: 391 SHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVND 450
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLI----ANQQDVT 727
+ ++ +F VKEN+ IF + V + + ++ ++
Sbjct: 451 NAPAFAQPEYT--VF-VKENNPPGC--HIFTVSAWDADAQENALVSYSLVERRVGERALS 505
Query: 728 DDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
+++ AE G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 506 SYVSVHAESGKVYALQPLDHEELELLQFQVTAR-DAGVPPLGSNVTLQVFVLDENDNAPA 564
Query: 787 FEHATYEGFIMENSK-IGTEIKMDNI---IKATDADEGTNALFMYTL---FGEGKEMFDV 839
G S+ + + + ++ ++A DAD G NA Y L G + F V
Sbjct: 565 LLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRV 624
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMI 883
TG + +LD ++L ++ +D G + A +++
Sbjct: 625 GLYTGEIS-TTRALDETDAPRHRLLVLVKDHGEPALTATATVLV 667
Score = 74.1 bits (174), Expect = 3e-12
Identities = 104/475 (21%), Positives = 180/475 (37%), Gaps = 30/475 (6%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +V+V + D NDN PVF P+ S+ + + + A D D+G
Sbjct: 105 HLEVIVDRPLQVFHVDVEVRDINDNPPVF-PATQKNLSIAESRPLDSRFPLEGASDADIG 163
Query: 491 QNGMVLYDLQRTSNLTITSP--FKINPNTGTVSVAESPILEGRHALFVEASDQPANPSER 548
+N ++ Y L ++ P ++ G + E V + P
Sbjct: 164 ENALLTYRLSPNEYFSLEKPPDDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPE-- 221
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDV 606
T+++ + P F Y+ + NV GT V ++ +D E D+
Sbjct: 222 ----LTGTVQLLITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDI 277
Query: 607 SYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
Y + V F ++ +G I V + Y+ + + L + + V
Sbjct: 278 VYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGI-DKGQLPLSGHCRV 336
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
+V+V D + + ++E++ + + + + NG V + +
Sbjct: 337 -IVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGL--VTCSLTSHV 393
Query: 725 DVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
++ LDRE Y + V A + G S V++ + D NDN
Sbjct: 394 PFKLVSTFKNYYSLVLDSALDRESVSAYELVVTAR-DGGSPSLWATASVSVEVADVNDNA 452
Query: 785 PVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF----GEG--KEMFD 838
P F Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 453 PAFAQPEYTVFVKENNPPGCHIFT---VSAWDADAQENALVSYSLVERRVGERALSSYVS 509
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 510 VHAESGKVYAL-QPLDHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAP 563
Score = 72.9 bits (171), Expect = 8e-12
Identities = 52/157 (33%), Positives = 78/157 (49%), Gaps = 20/157 (12%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDS------VNG-SLFLEKELDLDAEHNLQANTF 272
A D D+G A L Y L + + FSL+ V G L L K LD + +A
Sbjct: 157 ASDADIGENALLTYRL---SPNEYFSLEKPPDDELVKGLGLILRKSLDRE-----EAPEI 208
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
L + A+ P T ++ I +LD NDN P F+ Y + ++EN+PNG V+++ A+D
Sbjct: 209 FLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASD 268
Query: 333 KDQGENGEFTYQLDDP-----KGAFSIDPRSGWLTVR 364
D+G NG+ Y + K F IDP +G + V+
Sbjct: 269 LDEGLNGDIVYSFSNDISPNVKSKFHIDPITGQIIVK 305
Score = 67.3 bits (157), Expect = 4e-10
Identities = 73/290 (25%), Positives = 115/290 (39%), Gaps = 18/290 (6%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L G +++ + + + + D NDN P F T Y V + E P G + +
Sbjct: 212 LTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDE 271
Query: 127 SLTIPLTVPRGLTIFKDIRAFDRDKPNT-----------PNSDVHYSIVSGNDDGHFALE 175
L + I ++++ P T S + IV G D G L
Sbjct: 272 GLNGDIVYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPL- 330
Query: 176 SSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
S H V++ + + + D EF+ + + + + I D+D+GV + L
Sbjct: 331 SGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIAL-ISVSDKDMGVNGLVTCSL 389
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIE 295
S KL S SL L+ LD ++ + + L V A +P A A V +E
Sbjct: 390 TSHVPFKLVSTFKNYYSLVLDSALDRES-----VSAYELVVTARDGGSPSLWATASVSVE 444
Query: 296 LLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+ D+NDN P F Y + + EN P G + V A D D EN +Y L
Sbjct: 445 VADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSL 494
Score = 63.7 bits (148), Expect = 5e-09
Identities = 48/164 (29%), Positives = 75/164 (45%), Gaps = 6/164 (3%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I + +D E+ Y + ++ +KG + +G +V + +ED NDN P E +
Sbjct: 300 GQIIVKGYIDFEESKSYEI-IVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLP 358
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
I E++ +GT I + I +D D G N L +L + +LDR
Sbjct: 359 IREDAPLGTVIAL---ISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSALDR 415
Query: 856 EKKIMYKLSLVARDTGGLS--SEAELIIMIGDENDNKPEFNQIE 897
E Y+L + ARD G S + A + + + D NDN P F Q E
Sbjct: 416 ESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPE 459
Score = 63.3 bits (147), Expect = 6e-09
Identities = 50/172 (29%), Positives = 83/172 (48%), Gaps = 14/172 (8%)
Query: 728 DDIAIAEDGTIFTQKPLDREKR-DVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
DD + G I +K LDRE+ +++ + + K ++G Q+ I + D NDN P
Sbjct: 185 DDELVKGLGLIL-RKSLDREEAPEIFLVLTATDGGKPELTGT--VQLLITVLDANDNAPA 241
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGE----GKEMFDVDEN 842
F+ Y+ ++EN GT + N A+D DEG N +Y+ + K F +D
Sbjct: 242 FDRTIYKVRLLENVPNGTLVIKLN---ASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPI 298
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIGDENDNKPE 892
TG + + +D E+ Y++ + D G L S +I+ + D NDN P+
Sbjct: 299 TGQI-IVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPD 349
Score = 59.7 bits (138), Expect = 8e-08
Identities = 62/221 (28%), Positives = 94/221 (42%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y E +
Sbjct: 443 VEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSL-VERRVGE 501
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVF 1034
LS+ Y ++ G V + L E + ++A D G L N++++VF
Sbjct: 502 RALSS-------YVSVHAESGKVYALQPLDHEELELLQFQVTARDAGVPPLGSNVTLQVF 554
Query: 1035 VKDVNDHFPVF---KKTWYNFNVEE----AQYTRRVLGKVDATDADFGQNANLTYFIQP- 1086
V D ND+ P + V E + V+ KV A DAD G NA L+Y +QP
Sbjct: 555 VLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPG 614
Query: 1087 -SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+PF + TG +S LD ++ L V+ +D+G
Sbjct: 615 TGGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHG 655
Score = 59.3 bits (137), Expect = 1e-07
Identities = 70/245 (28%), Positives = 105/245 (42%), Gaps = 23/245 (9%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
I+EV+ N D++ I E+ P+GT I ++ D D G+NG + S V
Sbjct: 337 IVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHV--- 393
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRV 1033
P KL + K Y+ + ++ +L ES + L ++A DGG+ L SV V
Sbjct: 394 PFKLVST---FKNYYSL-------VLDSALDRESVSAYELVVTARDGGSPSLWATASVSV 443
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTD 1090
V DVND+ P F + Y V+E + V A DAD +NA ++Y + + +
Sbjct: 444 EVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERA 503
Query: 1091 LPFEIS--PLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
L +S +G + LD E + V ARD G D NDN+
Sbjct: 504 LSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDAG-VPPLGSNVTLQVFVLDENDNA 562
Query: 1149 PKFYA 1153
P A
Sbjct: 563 PALLA 567
Score = 47.6 bits (108), Expect = 3e-04
Identities = 52/186 (27%), Positives = 85/186 (45%), Gaps = 18/186 (9%)
Query: 175 ESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVG-ATL-- 231
+ S + +LLL + ++AG+ + + K H + I QDLG+ A L
Sbjct: 9 QESRRLLLLLLLLAAWEAGNGQLHYSVSEEAK--HGTF-----VGRIAQDLGLELAELVP 61
Query: 232 -RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQVQASQLNNPLKTAQ 289
+ + S L ++ NG LF+ +D + A + L+V ++ PL+
Sbjct: 62 RLFRVASKGRGGLLEVNLQNGILFVNSRIDREELCRRSAECSIHLEVI---VDRPLQVFH 118
Query: 290 ARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
V++E+ D+NDN P F N+SI E+ P A+D D GEN TY+L P
Sbjct: 119 --VDVEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRL-SPN 175
Query: 350 GAFSID 355
FS++
Sbjct: 176 EYFSLE 181
Score = 46.0 bits (104), Expect = 0.001
Identities = 32/108 (29%), Positives = 52/108 (48%), Gaps = 7/108 (6%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++TV D D + P F Y++ + ENV ++ LN ++ E
Sbjct: 218 GKPELTGTVQLLITVLDAND-----NAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIV 1333
N + Y N+ +++ F IDP G + + D E +YE+IV
Sbjct: 273 LNGDIVYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIV 320
Score = 43.6 bits (98), Expect = 0.006
Identities = 90/377 (23%), Positives = 147/377 (38%), Gaps = 36/377 (9%)
Query: 44 VDSDSPQNVVKFRLGCDFDEGDDLVRIGAGLNQ----ISAYLSVTVYIEDVNDNVPIFLD 99
+D + Q +VK + DF+E I G+++ +S + V V +ED NDNVP
Sbjct: 295 IDPITGQIIVKGYI--DFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEF 352
Query: 100 TPYHVTVDELTPTGEKAFIFLIAP----IGPSLTIPLT--VPRGL-TIFKDIRAFDRDKP 152
+ + E P G + ++ + +T LT VP L + FK+ + D
Sbjct: 353 KSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSA 412
Query: 153 NTPNSDVHYS-IVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKE 211
S Y +V+ D G +L ++ + + V D + + +
Sbjct: 413 LDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGC 472
Query: 212 ILFPEPIHAIDQDLGVGATLRYELISGN--DRKLFSLDSVN---GSLFLEKELDLDAEHN 266
+F + A D D A + Y L+ +R L S SV+ G ++ + LD +
Sbjct: 473 HIFT--VSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELEL 530
Query: 267 LQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLP--- 320
LQ QV A P + +++ +LD NDN P ++ E +P
Sbjct: 531 LQ-----FQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSV 585
Query: 321 -NGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLT--VRNQTVLDREAHSSL 377
G V +V A D D G N +Y+L G I R G T + LD
Sbjct: 586 GVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAPRH 645
Query: 378 RMKVYAKE-TNPSVVGT 393
R+ V K+ P++ T
Sbjct: 646 RLLVLVKDHGEPALTAT 662
>AC005609-10|AAC34322.1| 798|Homo sapiens KIAA0345-like 10 protein.
Length = 798
Score = 103 bits (246), Expect = 7e-21
Identities = 115/427 (26%), Positives = 183/427 (42%), Gaps = 60/427 (14%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAG--IYQVTIYIEDENDNPPVFEHAT 791
++G +F +DRE ++ R + + VI ++ V + + D NDNPPVF
Sbjct: 80 QNGILFVNSRIDRE--ELCRRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPVFPATQ 137
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD 851
I E+ + + ++ A+DAD G NAL Y L E F +++
Sbjct: 138 KNLSIAESRPLDSRFPLEG---ASDADIGENALLTYRL--SPNEYFSLEKPP-------- 184
Query: 852 SLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
+ +++ L L+ R + E+ +++ + KPE L
Sbjct: 185 ----DDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPE-----------------LT 223
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
GT +I V N A D+ + EN+P GT +IKLNA DLD GLNG I Y F+
Sbjct: 224 GTVQL-LITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFS 282
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN--LND 1027
++ I P+ VK F I+ G +IV + E + + + +D G L+
Sbjct: 283 ND--ISPN--------VKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSG 332
Query: 1028 NISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
+ V V V+D ND+ P + + + E V+ + +D D G N +T +
Sbjct: 333 HCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSL--- 389
Query: 1088 DTDLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDV 1144
+ +PF+ +S S ++ LDRE+ Y L V ARD G DV
Sbjct: 390 TSHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGG-SPSLWATASVSVEVADV 448
Query: 1145 NDNSPKF 1151
NDN+P F
Sbjct: 449 NDNAPAF 455
Score = 88.6 bits (210), Expect = 1e-16
Identities = 111/464 (23%), Positives = 197/464 (42%), Gaps = 35/464 (7%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + +T+LDANDN P F +Y+ + N GT++ K+ A D D G NG ++Y
Sbjct: 221 ELTGTVQLLITVLDANDNAPAF-DRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVY 279
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + S F I+P TG + V E + + VE D+ P V
Sbjct: 280 SFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGH---CRV 336
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+EV + N ++PD + + +GT + I V+D + V+ +
Sbjct: 337 IVEV----EDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSD--KDMGVNGLVTCSLT 390
Query: 616 EGVPF-AVEERSGVITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVND 671
VPF V ++V D L R + Y+ A + +L + +V V DVND
Sbjct: 391 SHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVND 450
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLI----ANQQDVT 727
+ ++ +F VKEN+ IF + V + + ++ ++
Sbjct: 451 NAPAFAQPEYT--VF-VKENNPPGC--HIFTVSAWDADAQENALVSYSLVERRVGERALS 505
Query: 728 DDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
+++ AE G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 506 SYVSVHAESGKVYALQPLDHEELELLQFQVTAR-DAGVPPLGSNVTLQVFVLDENDNAPA 564
Query: 787 FEHATYEGFIMENSK-IGTEIKMDNI---IKATDADEGTNALFMYTL---FGEGKEMFDV 839
G S+ + + + ++ ++A DAD G NA Y L G + F V
Sbjct: 565 LLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRV 624
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMI 883
TG + +LD ++L ++ +D G + A +++
Sbjct: 625 GLYTGEIS-TTRALDETDAPRHRLLVLVKDHGEPALTATATVLV 667
Score = 74.1 bits (174), Expect = 3e-12
Identities = 104/475 (21%), Positives = 180/475 (37%), Gaps = 30/475 (6%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +V+V + D NDN PVF P+ S+ + + + A D D+G
Sbjct: 105 HLEVIVDRPLQVFHVDVEVRDINDNPPVF-PATQKNLSIAESRPLDSRFPLEGASDADIG 163
Query: 491 QNGMVLYDLQRTSNLTITSP--FKINPNTGTVSVAESPILEGRHALFVEASDQPANPSER 548
+N ++ Y L ++ P ++ G + E V + P
Sbjct: 164 ENALLTYRLSPNEYFSLEKPPDDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPE-- 221
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDV 606
T+++ + P F Y+ + NV GT V ++ +D E D+
Sbjct: 222 ----LTGTVQLLITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDI 277
Query: 607 SYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
Y + V F ++ +G I V + Y+ + + L + + V
Sbjct: 278 VYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGI-DKGQLPLSGHCRV 336
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
+V+V D + + ++E++ + + + + NG V + +
Sbjct: 337 -IVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGL--VTCSLTSHV 393
Query: 725 DVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
++ LDRE Y + V A + G S V++ + D NDN
Sbjct: 394 PFKLVSTFKNYYSLVLDSALDRESVSAYELVVTAR-DGGSPSLWATASVSVEVADVNDNA 452
Query: 785 PVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF----GEG--KEMFD 838
P F Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 453 PAFAQPEYTVFVKENNPPGCHIFT---VSAWDADAQENALVSYSLVERRVGERALSSYVS 509
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 510 VHAESGKVYAL-QPLDHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAP 563
Score = 72.9 bits (171), Expect = 8e-12
Identities = 52/157 (33%), Positives = 78/157 (49%), Gaps = 20/157 (12%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDS------VNG-SLFLEKELDLDAEHNLQANTF 272
A D D+G A L Y L + + FSL+ V G L L K LD + +A
Sbjct: 157 ASDADIGENALLTYRL---SPNEYFSLEKPPDDELVKGLGLILRKSLDRE-----EAPEI 208
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
L + A+ P T ++ I +LD NDN P F+ Y + ++EN+PNG V+++ A+D
Sbjct: 209 FLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASD 268
Query: 333 KDQGENGEFTYQLDDP-----KGAFSIDPRSGWLTVR 364
D+G NG+ Y + K F IDP +G + V+
Sbjct: 269 LDEGLNGDIVYSFSNDISPNVKSKFHIDPITGQIIVK 305
Score = 67.3 bits (157), Expect = 4e-10
Identities = 73/290 (25%), Positives = 115/290 (39%), Gaps = 18/290 (6%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L G +++ + + + + D NDN P F T Y V + E P G + +
Sbjct: 212 LTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDE 271
Query: 127 SLTIPLTVPRGLTIFKDIRAFDRDKPNT-----------PNSDVHYSIVSGNDDGHFALE 175
L + I ++++ P T S + IV G D G L
Sbjct: 272 GLNGDIVYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPL- 330
Query: 176 SSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
S H V++ + + + D EF+ + + + + I D+D+GV + L
Sbjct: 331 SGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIAL-ISVSDKDMGVNGLVTCSL 389
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIE 295
S KL S SL L+ LD ++ + + L V A +P A A V +E
Sbjct: 390 TSHVPFKLVSTFKNYYSLVLDSALDRES-----VSAYELVVTARDGGSPSLWATASVSVE 444
Query: 296 LLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+ D+NDN P F Y + + EN P G + V A D D EN +Y L
Sbjct: 445 VADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSL 494
Score = 63.7 bits (148), Expect = 5e-09
Identities = 48/164 (29%), Positives = 75/164 (45%), Gaps = 6/164 (3%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I + +D E+ Y + ++ +KG + +G +V + +ED NDN P E +
Sbjct: 300 GQIIVKGYIDFEESKSYEI-IVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLP 358
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
I E++ +GT I + I +D D G N L +L + +LDR
Sbjct: 359 IREDAPLGTVIAL---ISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSALDR 415
Query: 856 EKKIMYKLSLVARDTGGLS--SEAELIIMIGDENDNKPEFNQIE 897
E Y+L + ARD G S + A + + + D NDN P F Q E
Sbjct: 416 ESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPE 459
Score = 63.3 bits (147), Expect = 6e-09
Identities = 50/172 (29%), Positives = 83/172 (48%), Gaps = 14/172 (8%)
Query: 728 DDIAIAEDGTIFTQKPLDREKR-DVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
DD + G I +K LDRE+ +++ + + K ++G Q+ I + D NDN P
Sbjct: 185 DDELVKGLGLIL-RKSLDREEAPEIFLVLTATDGGKPELTGT--VQLLITVLDANDNAPA 241
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGE----GKEMFDVDEN 842
F+ Y+ ++EN GT + N A+D DEG N +Y+ + K F +D
Sbjct: 242 FDRTIYKVRLLENVPNGTLVIKLN---ASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPI 298
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIGDENDNKPE 892
TG + + +D E+ Y++ + D G L S +I+ + D NDN P+
Sbjct: 299 TGQI-IVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPD 349
Score = 59.7 bits (138), Expect = 8e-08
Identities = 62/221 (28%), Positives = 94/221 (42%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y E +
Sbjct: 443 VEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSL-VERRVGE 501
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVF 1034
LS+ Y ++ G V + L E + ++A D G L N++++VF
Sbjct: 502 RALSS-------YVSVHAESGKVYALQPLDHEELELLQFQVTARDAGVPPLGSNVTLQVF 554
Query: 1035 VKDVNDHFPVF---KKTWYNFNVEE----AQYTRRVLGKVDATDADFGQNANLTYFIQP- 1086
V D ND+ P + V E + V+ KV A DAD G NA L+Y +QP
Sbjct: 555 VLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPG 614
Query: 1087 -SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+PF + TG +S LD ++ L V+ +D+G
Sbjct: 615 TGGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHG 655
Score = 59.3 bits (137), Expect = 1e-07
Identities = 70/245 (28%), Positives = 105/245 (42%), Gaps = 23/245 (9%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
I+EV+ N D++ I E+ P+GT I ++ D D G+NG + S V
Sbjct: 337 IVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHV--- 393
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRV 1033
P KL + K Y+ + ++ +L ES + L ++A DGG+ L SV V
Sbjct: 394 PFKLVST---FKNYYSL-------VLDSALDRESVSAYELVVTARDGGSPSLWATASVSV 443
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTD 1090
V DVND+ P F + Y V+E + V A DAD +NA ++Y + + +
Sbjct: 444 EVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERA 503
Query: 1091 LPFEIS--PLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
L +S +G + LD E + V ARD G D NDN+
Sbjct: 504 LSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDAG-VPPLGSNVTLQVFVLDENDNA 562
Query: 1149 PKFYA 1153
P A
Sbjct: 563 PALLA 567
Score = 47.6 bits (108), Expect = 3e-04
Identities = 52/186 (27%), Positives = 85/186 (45%), Gaps = 18/186 (9%)
Query: 175 ESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVG-ATL-- 231
+ S + +LLL + ++AG+ + + K H + I QDLG+ A L
Sbjct: 9 QESRRLLLLLLLLAAWEAGNGQLHYSVSEEAK--HGTF-----VGRIAQDLGLELAELVP 61
Query: 232 -RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQVQASQLNNPLKTAQ 289
+ + S L ++ NG LF+ +D + A + L+V ++ PL+
Sbjct: 62 RLFRVASKGRGGLLEVNLQNGILFVNSRIDREELCRRSAECSIHLEVI---VDRPLQVFH 118
Query: 290 ARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
V++E+ D+NDN P F N+SI E+ P A+D D GEN TY+L P
Sbjct: 119 --VDVEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRL-SPN 175
Query: 350 GAFSID 355
FS++
Sbjct: 176 EYFSLE 181
Score = 46.0 bits (104), Expect = 0.001
Identities = 32/108 (29%), Positives = 52/108 (48%), Gaps = 7/108 (6%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++TV D D + P F Y++ + ENV ++ LN ++ E
Sbjct: 218 GKPELTGTVQLLITVLDAND-----NAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIV 1333
N + Y N+ +++ F IDP G + + D E +YE+IV
Sbjct: 273 LNGDIVYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIV 320
Score = 43.6 bits (98), Expect = 0.006
Identities = 90/377 (23%), Positives = 147/377 (38%), Gaps = 36/377 (9%)
Query: 44 VDSDSPQNVVKFRLGCDFDEGDDLVRIGAGLNQ----ISAYLSVTVYIEDVNDNVPIFLD 99
+D + Q +VK + DF+E I G+++ +S + V V +ED NDNVP
Sbjct: 295 IDPITGQIIVKGYI--DFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEF 352
Query: 100 TPYHVTVDELTPTGEKAFIFLIAP----IGPSLTIPLT--VPRGL-TIFKDIRAFDRDKP 152
+ + E P G + ++ + +T LT VP L + FK+ + D
Sbjct: 353 KSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSA 412
Query: 153 NTPNSDVHYS-IVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKE 211
S Y +V+ D G +L ++ + + V D + + +
Sbjct: 413 LDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGC 472
Query: 212 ILFPEPIHAIDQDLGVGATLRYELISGN--DRKLFSLDSVN---GSLFLEKELDLDAEHN 266
+F + A D D A + Y L+ +R L S SV+ G ++ + LD +
Sbjct: 473 HIFT--VSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELEL 530
Query: 267 LQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLP--- 320
LQ QV A P + +++ +LD NDN P ++ E +P
Sbjct: 531 LQ-----FQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSV 585
Query: 321 -NGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLT--VRNQTVLDREAHSSL 377
G V +V A D D G N +Y+L G I R G T + LD
Sbjct: 586 GVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAPRH 645
Query: 378 RMKVYAKE-TNPSVVGT 393
R+ V K+ P++ T
Sbjct: 646 RLLVLVKDHGEPALTAT 662
>AB208925-1|BAD92162.1| 921|Homo sapiens protocadherin alpha 4
isoform 1 precursor variant protein.
Length = 921
Score = 103 bits (246), Expect = 7e-21
Identities = 115/427 (26%), Positives = 183/427 (42%), Gaps = 60/427 (14%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAG--IYQVTIYIEDENDNPPVFEHAT 791
++G +F +DRE ++ R + + VI ++ V + + D NDNPPVF
Sbjct: 100 QNGILFVNSRIDRE--ELCRRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPVFPATQ 157
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD 851
I E+ + + ++ A+DAD G NAL Y L E F +++
Sbjct: 158 KNLSIAESRPLDSRFPLEG---ASDADIGENALLTYRL--SPNEYFSLEKPP-------- 204
Query: 852 SLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
+ +++ L L+ R + E+ +++ + KPE L
Sbjct: 205 ----DDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPE-----------------LT 243
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFN 971
GT +I V N A D+ + EN+P GT +IKLNA DLD GLNG I Y F+
Sbjct: 244 GTVQL-LITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFS 302
Query: 972 SEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN--LND 1027
++ I P+ VK F I+ G +IV + E + + + +D G L+
Sbjct: 303 ND--ISPN--------VKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSG 352
Query: 1028 NISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
+ V V V+D ND+ P + + + E V+ + +D D G N +T +
Sbjct: 353 HCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSL--- 409
Query: 1088 DTDLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDV 1144
+ +PF+ +S S ++ LDRE+ Y L V ARD G DV
Sbjct: 410 TSHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGG-SPSLWATASVSVEVADV 468
Query: 1145 NDNSPKF 1151
NDN+P F
Sbjct: 469 NDNAPAF 475
Score = 88.6 bits (210), Expect = 1e-16
Identities = 111/464 (23%), Positives = 197/464 (42%), Gaps = 35/464 (7%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + +T+LDANDN P F +Y+ + N GT++ K+ A D D G NG ++Y
Sbjct: 241 ELTGTVQLLITVLDANDNAPAF-DRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVY 299
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLAVV 555
+ + S F I+P TG + V E + + VE D+ P V
Sbjct: 300 SFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGH---CRV 356
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
+EV + N ++PD + + +GT + I V+D + V+ +
Sbjct: 357 IVEV----EDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSD--KDMGVNGLVTCSLT 410
Query: 616 EGVPF-AVEERSGVITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVND 671
VPF V ++V D L R + Y+ A + +L + +V V DVND
Sbjct: 411 SHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVND 470
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLI----ANQQDVT 727
+ ++ +F VKEN+ IF + V + + ++ ++
Sbjct: 471 NAPAFAQPEYT--VF-VKENNPPGC--HIFTVSAWDADAQENALVSYSLVERRVGERALS 525
Query: 728 DDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
+++ AE G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 526 SYVSVHAESGKVYALQPLDHEELELLQFQVTAR-DAGVPPLGSNVTLQVFVLDENDNAPA 584
Query: 787 FEHATYEGFIMENSK-IGTEIKMDNI---IKATDADEGTNALFMYTL---FGEGKEMFDV 839
G S+ + + + ++ ++A DAD G NA Y L G + F V
Sbjct: 585 LLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRV 644
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMI 883
TG + +LD ++L ++ +D G + A +++
Sbjct: 645 GLYTGEIS-TTRALDETDAPRHRLLVLVKDHGEPALTATATVLV 687
Score = 74.1 bits (174), Expect = 3e-12
Identities = 104/475 (21%), Positives = 180/475 (37%), Gaps = 30/475 (6%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +V+V + D NDN PVF P+ S+ + + + A D D+G
Sbjct: 125 HLEVIVDRPLQVFHVDVEVRDINDNPPVF-PATQKNLSIAESRPLDSRFPLEGASDADIG 183
Query: 491 QNGMVLYDLQRTSNLTITSP--FKINPNTGTVSVAESPILEGRHALFVEASDQPANPSER 548
+N ++ Y L ++ P ++ G + E V + P
Sbjct: 184 ENALLTYRLSPNEYFSLEKPPDDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPE-- 241
Query: 549 RYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDV 606
T+++ + P F Y+ + NV GT V ++ +D E D+
Sbjct: 242 ----LTGTVQLLITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDI 297
Query: 607 SYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATV 664
Y + V F ++ +G I V + Y+ + + L + + V
Sbjct: 298 VYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGI-DKGQLPLSGHCRV 356
Query: 665 HVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQ 724
+V+V D + + ++E++ + + + + NG V + +
Sbjct: 357 -IVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGL--VTCSLTSHV 413
Query: 725 DVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
++ LDRE Y + V A + G S V++ + D NDN
Sbjct: 414 PFKLVSTFKNYYSLVLDSALDRESVSAYELVVTAR-DGGSPSLWATASVSVEVADVNDNA 472
Query: 785 PVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLF----GEG--KEMFD 838
P F Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 473 PAFAQPEYTVFVKENNPPGCHIFT---VSAWDADAQENALVSYSLVERRVGERALSSYVS 529
Query: 839 VDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 530 VHAESGKVYAL-QPLDHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAP 583
Score = 72.9 bits (171), Expect = 8e-12
Identities = 52/157 (33%), Positives = 78/157 (49%), Gaps = 20/157 (12%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDS------VNG-SLFLEKELDLDAEHNLQANTF 272
A D D+G A L Y L + + FSL+ V G L L K LD + +A
Sbjct: 177 ASDADIGENALLTYRL---SPNEYFSLEKPPDDELVKGLGLILRKSLDRE-----EAPEI 228
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
L + A+ P T ++ I +LD NDN P F+ Y + ++EN+PNG V+++ A+D
Sbjct: 229 FLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASD 288
Query: 333 KDQGENGEFTYQLDDP-----KGAFSIDPRSGWLTVR 364
D+G NG+ Y + K F IDP +G + V+
Sbjct: 289 LDEGLNGDIVYSFSNDISPNVKSKFHIDPITGQIIVK 325
Score = 67.3 bits (157), Expect = 4e-10
Identities = 73/290 (25%), Positives = 115/290 (39%), Gaps = 18/290 (6%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L G +++ + + + + D NDN P F T Y V + E P G + +
Sbjct: 232 LTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDE 291
Query: 127 SLTIPLTVPRGLTIFKDIRAFDRDKPNT-----------PNSDVHYSIVSGNDDGHFALE 175
L + I ++++ P T S + IV G D G L
Sbjct: 292 GLNGDIVYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPL- 350
Query: 176 SSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL 235
S H V++ + + + D EF+ + + + + I D+D+GV + L
Sbjct: 351 SGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIAL-ISVSDKDMGVNGLVTCSL 409
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIE 295
S KL S SL L+ LD ++ + + L V A +P A A V +E
Sbjct: 410 TSHVPFKLVSTFKNYYSLVLDSALDRES-----VSAYELVVTARDGGSPSLWATASVSVE 464
Query: 296 LLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+ D+NDN P F Y + + EN P G + V A D D EN +Y L
Sbjct: 465 VADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSL 514
Score = 63.7 bits (148), Expect = 5e-09
Identities = 48/164 (29%), Positives = 75/164 (45%), Gaps = 6/164 (3%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I + +D E+ Y + ++ +KG + +G +V + +ED NDN P E +
Sbjct: 320 GQIIVKGYIDFEESKSYEI-IVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLP 378
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
I E++ +GT I + I +D D G N L +L + +LDR
Sbjct: 379 IREDAPLGTVIAL---ISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSALDR 435
Query: 856 EKKIMYKLSLVARDTGGLS--SEAELIIMIGDENDNKPEFNQIE 897
E Y+L + ARD G S + A + + + D NDN P F Q E
Sbjct: 436 ESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPE 479
Score = 63.3 bits (147), Expect = 6e-09
Identities = 50/172 (29%), Positives = 83/172 (48%), Gaps = 14/172 (8%)
Query: 728 DDIAIAEDGTIFTQKPLDREKR-DVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
DD + G I +K LDRE+ +++ + + K ++G Q+ I + D NDN P
Sbjct: 205 DDELVKGLGLIL-RKSLDREEAPEIFLVLTATDGGKPELTGT--VQLLITVLDANDNAPA 261
Query: 787 FEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGE----GKEMFDVDEN 842
F+ Y+ ++EN GT + N A+D DEG N +Y+ + K F +D
Sbjct: 262 FDRTIYKVRLLENVPNGTLVIKLN---ASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPI 318
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTGGL--SSEAELIIMIGDENDNKPE 892
TG + + +D E+ Y++ + D G L S +I+ + D NDN P+
Sbjct: 319 TGQI-IVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPD 369
Score = 59.7 bits (138), Expect = 8e-08
Identities = 62/221 (28%), Positives = 94/221 (42%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y E +
Sbjct: 463 VEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSL-VERRVGE 521
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVF 1034
LS+ Y ++ G V + L E + ++A D G L N++++VF
Sbjct: 522 RALSS-------YVSVHAESGKVYALQPLDHEELELLQFQVTARDAGVPPLGSNVTLQVF 574
Query: 1035 VKDVNDHFPVF---KKTWYNFNVEE----AQYTRRVLGKVDATDADFGQNANLTYFIQP- 1086
V D ND+ P + V E + V+ KV A DAD G NA L+Y +QP
Sbjct: 575 VLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPG 634
Query: 1087 -SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+PF + TG +S LD ++ L V+ +D+G
Sbjct: 635 TGGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHG 675
Score = 59.3 bits (137), Expect = 1e-07
Identities = 70/245 (28%), Positives = 105/245 (42%), Gaps = 23/245 (9%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
I+EV+ N D++ I E+ P+GT I ++ D D G+NG + S V
Sbjct: 357 IVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHV--- 413
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRV 1033
P KL + K Y+ + ++ +L ES + L ++A DGG+ L SV V
Sbjct: 414 PFKLVST---FKNYYSL-------VLDSALDRESVSAYELVVTARDGGSPSLWATASVSV 463
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTD 1090
V DVND+ P F + Y V+E + V A DAD +NA ++Y + + +
Sbjct: 464 EVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERA 523
Query: 1091 LPFEIS--PLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
L +S +G + LD E + V ARD G D NDN+
Sbjct: 524 LSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDAG-VPPLGSNVTLQVFVLDENDNA 582
Query: 1149 PKFYA 1153
P A
Sbjct: 583 PALLA 587
Score = 47.6 bits (108), Expect = 3e-04
Identities = 52/186 (27%), Positives = 85/186 (45%), Gaps = 18/186 (9%)
Query: 175 ESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVG-ATL-- 231
+ S + +LLL + ++AG+ + + K H + I QDLG+ A L
Sbjct: 29 QESRRLLLLLLLLAAWEAGNGQLHYSVSEEAK--HGTF-----VGRIAQDLGLELAELVP 81
Query: 232 -RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQVQASQLNNPLKTAQ 289
+ + S L ++ NG LF+ +D + A + L+V ++ PL+
Sbjct: 82 RLFRVASKGRGGLLEVNLQNGILFVNSRIDREELCRRSAECSIHLEVI---VDRPLQVFH 138
Query: 290 ARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
V++E+ D+NDN P F N+SI E+ P A+D D GEN TY+L P
Sbjct: 139 --VDVEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRL-SPN 195
Query: 350 GAFSID 355
FS++
Sbjct: 196 EYFSLE 201
Score = 46.0 bits (104), Expect = 0.001
Identities = 32/108 (29%), Positives = 52/108 (48%), Gaps = 7/108 (6%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++TV D D + P F Y++ + ENV ++ LN ++ E
Sbjct: 238 GKPELTGTVQLLITVLDAND-----NAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEG 292
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIV 1333
N + Y N+ +++ F IDP G + + D E +YE+IV
Sbjct: 293 LNGDIVYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIV 340
Score = 43.6 bits (98), Expect = 0.006
Identities = 90/377 (23%), Positives = 147/377 (38%), Gaps = 36/377 (9%)
Query: 44 VDSDSPQNVVKFRLGCDFDEGDDLVRIGAGLNQ----ISAYLSVTVYIEDVNDNVPIFLD 99
+D + Q +VK + DF+E I G+++ +S + V V +ED NDNVP
Sbjct: 315 IDPITGQIIVKGYI--DFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEF 372
Query: 100 TPYHVTVDELTPTGEKAFIFLIAP----IGPSLTIPLT--VPRGL-TIFKDIRAFDRDKP 152
+ + E P G + ++ + +T LT VP L + FK+ + D
Sbjct: 373 KSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSA 432
Query: 153 NTPNSDVHYS-IVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKE 211
S Y +V+ D G +L ++ + + V D + + +
Sbjct: 433 LDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGC 492
Query: 212 ILFPEPIHAIDQDLGVGATLRYELISGN--DRKLFSLDSVN---GSLFLEKELDLDAEHN 266
+F + A D D A + Y L+ +R L S SV+ G ++ + LD +
Sbjct: 493 HIFT--VSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELEL 550
Query: 267 LQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLP--- 320
LQ QV A P + +++ +LD NDN P ++ E +P
Sbjct: 551 LQ-----FQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSV 605
Query: 321 -NGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLT--VRNQTVLDREAHSSL 377
G V +V A D D G N +Y+L G I R G T + LD
Sbjct: 606 GVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAPRH 665
Query: 378 RMKVYAKE-TNPSVVGT 393
R+ V K+ P++ T
Sbjct: 666 RLLVLVKDHGEPALTAT 682
>AB046841-1|BAB13447.1| 787|Homo sapiens KIAA1621 protein protein.
Length = 787
Score = 103 bits (246), Expect = 7e-21
Identities = 127/496 (25%), Positives = 208/496 (41%), Gaps = 69/496 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
IPEN P+GT +ALDLD G N Y+ + P S E F ++
Sbjct: 153 IPENSPLGTEFPLNHALDLDVGSNNVQNYKIS-----PSSHFRVLIHE----FRDGRKYP 203
Query: 1000 HVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
+++ + L E E RL ++ALDGG+ + VR+ V D+ND+ P F++ Y +
Sbjct: 204 ELVLDKELDREEEPQLRLTLTALDGGSPPRSGTAQVRIEVVDINDNAPEFEQPIYKVQIP 263
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTY-FIQPS-DTDLPFEISPLTGVLSVNGELDRETE 1113
E ++ V A D D G N ++Y QPS D E++P+TG + + ++D E
Sbjct: 264 ENSPLGSLVATVSARDLDGGANGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFEMV 323
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK--FYAFDELLEWKHPE------- 1164
Y + + A D G DVNDN P+ A + PE
Sbjct: 324 TSYEVRIKATDGG---GLSGKCTLLLQVVDVNDNPPQVTMSALTSPIPENSPEIVVAVFS 380
Query: 1165 -ADELSNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQR 1221
+D S +N +++ ++I+E+ P + +V + T+ + Y++
Sbjct: 381 VSDPDSGNNGKTI-------SSIQEDLPFLLKPSVKNFYTLVTERALDREARAEYNI--T 431
Query: 1222 KNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNL 1281
++G P L + + V ++DV D + P F Y L + EN + + + S++
Sbjct: 432 LTVTDMGTPRLKTEHNITVQISDVND-----NAPTFTQTSYTLFVRENNSPALHIGSVSA 486
Query: 1282 TEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREVKDTYEVIVRAER 1337
T+ N ++ Y +L D + + I+ NG L+ +RS D E +E V A
Sbjct: 487 TDRDSGINAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEALREFEFRVSAT- 545
Query: 1338 QKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTNGNRPLVTAIPT 1393
R P + + V V + D NDNSP NG+ P +P
Sbjct: 546 ---DRGSPAL-------------SSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPR 589
Query: 1394 TAPFGYQVMQLKGAIG 1409
A GY V ++ G
Sbjct: 590 AAEPGYLVTKVVAVDG 605
Score = 91.1 bits (216), Expect = 3e-17
Identities = 115/472 (24%), Positives = 196/472 (41%), Gaps = 40/472 (8%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E + E+ ++D ND++P+F + + N+ +GT A+D D+G N +
Sbjct: 122 ENPLEIFQAELRVIDINDHSPMFTEKEMI-LKIPENSPLGTEFPLNHALDLDVGSNNVQN 180
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLA 553
Y + +S+ + + V + + E + L + A D + P R A
Sbjct: 181 YKISPSSHFRVLIHEFRDGRKYPELVLDKELDREEEPQLRLTLTALDGGSPP---RSGTA 237
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLL 611
V IEV + P+F Y+ + N +G+ V + D +SY L
Sbjct: 238 QVRIEVV----DINDNAPEFEQPIYKVQIPENSPLGSLVATVSARDLDGGANGKISYTLF 293
Query: 612 HGYEE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
E+ V +G + + + Y+ A + LS + VVDVN
Sbjct: 294 QPSEDISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIKAT-DGGGLSGKCTLLLQVVDVN 352
Query: 671 DERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D V + SPI ENS + ++ S GN N + + + Q+D+
Sbjct: 353 DNPPQVTMSALTSPI----PENSPEIVVAVFSVSDPDS--GN---NGKTISSIQEDLPFL 403
Query: 730 I--AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVF 787
+ ++ T+ T++ LDRE R Y +T+ + G + +T+ I D NDN P F
Sbjct: 404 LKPSVKNFYTLVTERALDREARAEYNITLTVT-DMGTPRLKTEHNITVQISDVNDNAPTF 462
Query: 788 EHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDE 841
+Y F+ EN+ I + ATD D G NA Y+L + ++
Sbjct: 463 TQTSYTLFVRENNSPALHI---GSVSATDRDSGINAQVTYSLLPPQDPHLPLASLVSINA 519
Query: 842 NTGVVKFIGDSLDRE--KKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKP 891
+ G + F SLD E ++ +++S R + LSSEA + +++ D NDN P
Sbjct: 520 DNGHL-FALRSLDYEALREFEFRVSATDRGSPALSSEALVRVLVLDANDNSP 570
Score = 89.8 bits (213), Expect = 6e-17
Identities = 73/242 (30%), Positives = 116/242 (47%), Gaps = 19/242 (7%)
Query: 659 VTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR- 717
+ A + V+D+ND + + +I + ENS +G F N + G+ NV+
Sbjct: 127 IFQAELRVIDINDHSPMFTE---KEMILKIPENSP---LGTEFPLNHALDLDVGSNNVQN 180
Query: 718 FLIANQQDVTDDIAIAEDGTIFTQ----KPLDREKRDVYRMTVIAEFNKGVISGAGIYQV 773
+ I+ I DG + + K LDRE+ R+T+ A + G +G QV
Sbjct: 181 YKISPSSHFRVLIHEFRDGRKYPELVLDKELDREEEPQLRLTLTA-LDGGSPPRSGTAQV 239
Query: 774 TIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG 833
I + D NDN P FE Y+ I ENS +G+ + + A D D G N YTLF
Sbjct: 240 RIEVVDINDNAPEFEQPIYKVQIPENSPLGSLVAT---VSARDLDGGANGKISYTLFQPS 296
Query: 834 KEM---FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNK 890
+++ +V+ TG V+ + +D E Y++ + A D GGLS + L++ + D NDN
Sbjct: 297 EDISKTLEVNPMTGEVR-LRKQVDFEMVTSYEVRIKATDGGGLSGKCTLLLQVVDVNDNP 355
Query: 891 PE 892
P+
Sbjct: 356 PQ 357
Score = 81.8 bits (193), Expect = 2e-14
Identities = 54/170 (31%), Positives = 85/170 (50%), Gaps = 13/170 (7%)
Query: 219 HAIDQDLGVGATLRYELISGNDRKLFSLDSVNG----SLFLEKELDLDAEHNLQANTFVL 274
HA+D D+G Y++ + ++ + +G L L+KELD + E L+ L
Sbjct: 167 HALDLDVGSNNVQNYKISPSSHFRVLIHEFRDGRKYPELVLDKELDREEEPQLR-----L 221
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A +P ++ A+V IE++D+NDN PEFE Y + I EN P G V V A D D
Sbjct: 222 TLTALDGGSPPRSGTAQVRIEVVDINDNAPEFEQPIYKVQIPENSPLGSLVATVSARDLD 281
Query: 335 QGENGEFTYQLDDPKGAFS----IDPRSGWLTVRNQTVLDREAHSSLRMK 380
G NG+ +Y L P S ++P +G + +R Q + +R+K
Sbjct: 282 GGANGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIK 331
Score = 76.2 bits (179), Expect = 9e-13
Identities = 74/246 (30%), Positives = 105/246 (42%), Gaps = 22/246 (8%)
Query: 911 NGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEF 970
+GTA I EV N A + +Q IPEN P+G+ + ++A DLD G NG+I Y
Sbjct: 234 SGTAQVRI-EVVDINDNAPEFEQPIYKVQIPENSPLGSLVATVSARDLDGGANGKISY-- 290
Query: 971 NSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDN 1028
PS+ + LEV N G V + + + E + + + I A DGG L+
Sbjct: 291 ---TLFQPSEDISKTLEV------NPMTGEVRLRKQVDFEMVTSYEVRIKATDGGGLSGK 341
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
++ + V DVND+ P + + E V+ +D D G N IQ
Sbjct: 342 CTLLLQVVDVNDNPPQVTMSALTSPIPE-NSPEIVVAVFSVSDPDSGNNGKTISSIQ--- 397
Query: 1089 TDLPFEISPLTG---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
DLPF + P L LDRE +Y +T+ D G DVN
Sbjct: 398 EDLPFLLKPSVKNFYTLVTERALDREARAEYNITLTVTDMG-TPRLKTEHNITVQISDVN 456
Query: 1146 DNSPKF 1151
DN+P F
Sbjct: 457 DNAPTF 462
Score = 67.3 bits (157), Expect = 4e-10
Identities = 81/299 (27%), Positives = 116/299 (38%), Gaps = 22/299 (7%)
Query: 858 KIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGTAG-- 915
KI Y L + D +S E+ M G+ K ++ + +VRI + T G +G
Sbjct: 287 KISYTLFQPSED---ISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRI-KATDGGGLSGKC 342
Query: 916 FTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVY 975
+++V N V IPEN P + + D DSG NG+ ++
Sbjct: 343 TLLLQVVDVNDNPPQVTMSALTSPIPENSP-EIVVAVFSVSDPDSGNNGKTISSIQEDL- 400
Query: 976 IPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGNLNDNISVRVFV 1035
P L Y ++ ER + R E L ++ + L ++ V +
Sbjct: 401 --PFLLKPSVKNF--YTLVTER----ALDREARAEYNITLTVTDMGTPRLKTEHNITVQI 452
Query: 1036 KDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSDTDLPF- 1093
DVND+ P F +T Y V E +G V ATD D G NA +TY + P D LP
Sbjct: 453 SDVNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGINAQVTYSLLPPQDPHLPLA 512
Query: 1094 ---EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
I+ G L LD E ++ V A D G D NDNSP
Sbjct: 513 SLVSINADNGHLFALRSLDYEALREFEFRVSATDRG-SPALSSEALVRVLVLDANDNSP 570
Score = 65.3 bits (152), Expect = 2e-09
Identities = 62/218 (28%), Positives = 91/218 (41%), Gaps = 18/218 (8%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+++ N A Q + EN I ++A D DSG+N Q+ Y +PP
Sbjct: 450 VQISDVNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGINAQVTYSL-----LPP 504
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVF 1034
L + IN +GH+ RSL E+ EF +SA D G+ L+ VRV
Sbjct: 505 QD---PHLPLASLVSINADNGHLFALRSLDYEALREFEFRVSATDRGSPALSSEALVRVL 561
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQPSD 1088
V D ND+ P N + + R ++ KV A D D GQNA L+Y + +
Sbjct: 562 VLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKAT 621
Query: 1089 TDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
F + G + L K+ L V+ +DNG
Sbjct: 622 EPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNG 659
Score = 61.7 bits (143), Expect = 2e-08
Identities = 53/181 (29%), Positives = 83/181 (45%), Gaps = 20/181 (11%)
Query: 218 IHAIDQDLGVGATLRYELISGND-----RKLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A D+D G+ A + Y L+ D L S+++ NG LF + LD +A F
Sbjct: 484 VSATDRDSGINAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEA-----LREF 538
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNIS--IVENLPN----GFSVL 326
+V A+ +P +++A V + +LD NDN P N S E +P G+ V
Sbjct: 539 EFRVSATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVT 598
Query: 327 QVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAK 384
+V+A D D G+N +YQL G F + +G VR +L + R+ V K
Sbjct: 599 KVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG--EVRTARLLSERDAAKHRLVVLVK 656
Query: 385 E 385
+
Sbjct: 657 D 657
Score = 60.1 bits (139), Expect = 6e-08
Identities = 50/169 (29%), Positives = 78/169 (46%), Gaps = 9/169 (5%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
A+ G + + LDRE+ I F + + I+Q + + D ND+ P+F
Sbjct: 90 AQTGDLLINEKLDREELCGPTEPCILHFQVLMENPLEIFQAELRVIDINDHSPMFTEKEM 149
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF---- 848
I ENS +GTE +++ A D D G+N + Y + + E K+
Sbjct: 150 ILKIPENSPLGTEFPLNH---ALDLDVGSNNVQNYKISPSSHFRVLIHEFRDGRKYPELV 206
Query: 849 IGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+ LDRE++ +L+L A D G S A++ I + D NDN PEF Q
Sbjct: 207 LDKELDREEEPQLRLTLTALDGGSPPRSGTAQVRIEVVDINDNAPEFEQ 255
Score = 57.6 bits (133), Expect = 3e-07
Identities = 86/364 (23%), Positives = 141/364 (38%), Gaps = 51/364 (14%)
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD----TD 1090
V D+NDH P+F + + E A D D G N Y I PS
Sbjct: 134 VIDINDHSPMFTEKEMILKIPENSPLGTEFPLNHALDLDVGSNNVQNYKISPSSHFRVLI 193
Query: 1091 LPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
F L ++ ELDRE E + LT+ A D G D+NDN+P+
Sbjct: 194 HEFRDGRKYPELVLDKELDREEEPQLRLTLTALDGG-SPPRSGTAQVRIEVVDINDNAPE 252
Query: 1151 FYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNG 1210
F + P +YK I EN+P+G+ VA V A D D G
Sbjct: 253 F---------EQP-----------------IYKVQIPENSPLGSLVATVSARDLD--GGA 284
Query: 1211 NGLILYSL--PQRKNQQNLGLPSLSSTAIL-------MVTVADV----PDEVEMSDKPVF 1257
NG I Y+L P + L + ++ L MVT +V D +S K
Sbjct: 285 NGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIKATDGGGLSGKCTL 344
Query: 1258 ISRYYELEIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYL 1317
+ + ++ + + ++ + E+ + + +++ D+ + + +L
Sbjct: 345 LLQVVDVN-DNPPQVTMSALTSPIPENSPEIVVAVFSVSDPDSGNNGKTISSIQEDLPFL 403
Query: 1318 VRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNS 1377
++ VK+ Y ++ + +R + I D+ K + + V+I DVNDN+
Sbjct: 404 LKP---SVKNFYTLVTERALDREAR-AEYNITLTVTDMGTPRLKTEHNITVQISDVNDNA 459
Query: 1378 PKFT 1381
P FT
Sbjct: 460 PTFT 463
Score = 54.0 bits (124), Expect = 4e-06
Identities = 71/291 (24%), Positives = 112/291 (38%), Gaps = 16/291 (5%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPI-- 124
L + G S V + + D+NDN P F Y V + E +P G +
Sbjct: 223 LTALDGGSPPRSGTAQVRIEVVDINDNAPEFEQPIYKVQIPENSPLGSLVATVSARDLDG 282
Query: 125 GPSLTIPLTVPR-GLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALES---SHKP 180
G + I T+ + I K + V + +V+ + A + S K
Sbjct: 283 GANGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFEMVTSYEVRIKATDGGGLSGKC 342
Query: 181 VLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND 240
LLL+ V D D Q+ + A I + PE + A+ + + IS
Sbjct: 343 TLLLQVV---DVNDNPPQVTMSALTSPIPENS--PEIVVAVFSVSDPDSGNNGKTISSIQ 397
Query: 241 RKL-FSLD-SVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
L F L SV L E LD E + N + + + + P + + +++ D
Sbjct: 398 EDLPFLLKPSVKNFYTLVTERALDREARAEYN---ITLTVTDMGTPRLKTEHNITVQISD 454
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
+NDN P F Y + + EN + V ATD+D G N + TY L P+
Sbjct: 455 VNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDSGINAQVTYSLLPPQ 505
Score = 48.0 bits (109), Expect = 3e-04
Identities = 48/172 (27%), Positives = 79/172 (45%), Gaps = 14/172 (8%)
Query: 221 IDQDLGVG----ATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ +DLG+G +T + +IS +++ L + G L + ++LD + E +L
Sbjct: 59 LGKDLGLGLTEMSTRKARIISQGNKQHLQLKAQTGDLLINEKLDRE-ELCGPTEPCILHF 117
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
Q + NPL+ QA E+ ++D+ND+ P F + I EN P G A D D G
Sbjct: 118 QVL-MENPLEIFQA--ELRVIDINDHSPMFTEKEMILKIPENSPLGTEFPLNHALDLDVG 174
Query: 337 ENGEFTYQLDDPKGAFSI---DPRSG--WLTVRNQTVLDREAHSSLRMKVYA 383
N Y++ P F + + R G + + LDRE LR+ + A
Sbjct: 175 SNNVQNYKI-SPSSHFRVLIHEFRDGRKYPELVLDKELDREEEPQLRLTLTA 225
Score = 41.9 bits (94), Expect = 0.017
Identities = 35/161 (21%), Positives = 72/161 (44%), Gaps = 12/161 (7%)
Query: 218 IHAIDQDLGVGATLRYELISGND--RKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQ 275
+ A D D G + Y L ++ K ++ + G + L K++D + ++ ++
Sbjct: 275 VSARDLDGGANGKISYTLFQPSEDISKTLEVNPMTGEVRLRKQVDFE-----MVTSYEVR 329
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
++A+ + + + ++++D+NDN P+ + I EN P V +D D
Sbjct: 330 IKATDGGG--LSGKCTLLLQVVDVNDNPPQVTMSALTSPIPENSPE-IVVAVFSVSDPDS 386
Query: 336 GENGEFTYQLDDPKGAFSIDPR-SGWLTVRNQTVLDREAHS 375
G NG+ + + F + P + T+ + LDREA +
Sbjct: 387 GNNGKTISSIQEDL-PFLLKPSVKNFYTLVTERALDREARA 426
Score = 39.5 bits (88), Expect = 0.091
Identities = 38/126 (30%), Positives = 54/126 (42%), Gaps = 8/126 (6%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 552 LSSEALVRVLVLDANDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 610
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSL 552
+ Y L + + + + N T + S +H L V D P +L
Sbjct: 611 AWLSYQLLKATEPGLFGVWAHNGEVRTARLL-SERDAAKHRLVVLVKDNGEPPCSATATL 669
Query: 553 AVVTIE 558
V+ ++
Sbjct: 670 HVLLVD 675
>BC104804-1|AAI04805.1| 950|Homo sapiens protocadherin alpha 9
protein.
Length = 950
Score = 102 bits (245), Expect = 9e-21
Identities = 116/425 (27%), Positives = 173/425 (40%), Gaps = 56/425 (13%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
++G +F +DRE+ V ++ V + ++D NDNPPVF
Sbjct: 80 QNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFPATQKN 139
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
FI E+ + + ++ A+DAD G NAL Y L DV + VK +G
Sbjct: 140 LFIAESRPLDSRFPLEG---ASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLG--- 193
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
LV R EL +++ + KPE L GT
Sbjct: 194 -----------LVLRKLLDREETPELHLLLTATDGGKPE-----------------LTGT 225
Query: 914 AGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
+I V N A D+ +PEN+ IGT +I NA DLD GLNG I Y F+S+
Sbjct: 226 VQL-LITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSD 284
Query: 974 VYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNI 1029
V + ++K F ++ G + V + E ++ + A+D G L +
Sbjct: 285 V----------SPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHC 334
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
++ V V DVND+ P + V+E V+ + D D N +T + P
Sbjct: 335 TLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTP--- 391
Query: 1090 DLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+PF+ +S S ++ LDRE+ Y L V ARD G DVND
Sbjct: 392 HVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGG-SPSLWATARVSVEVADVND 450
Query: 1147 NSPKF 1151
N+P F
Sbjct: 451 NAPAF 455
Score = 92.3 bits (219), Expect = 1e-17
Identities = 116/466 (24%), Positives = 191/466 (40%), Gaps = 39/466 (8%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + +T+LD NDN PVF LY + N +GT++ A D D G NG ++Y
Sbjct: 221 ELTGTVQLLITVLDNNDNAPVF-DRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIY 279
Query: 498 DLQRTSNLTITSPFKINPNTGTVSV-AESPILEGR-HALFVEASDQPANPSERRYSLAVV 555
+ I S F ++P +G ++V E R H + VEA D+ P +L V
Sbjct: 280 SFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVE 339
Query: 556 TIEVTRGTKGNKPDIP-DFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGY 614
++V N P + + P V + +GT + I V D D + +
Sbjct: 340 VVDV----NDNAPQLTIKTLSVP----VKEDAQLGTVIALISVIDL--DADANGQVTCSL 389
Query: 615 EEGVPF-AVEERSGVITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVN 670
VPF V ++V D L R + Y+ A + +L +V V DVN
Sbjct: 390 TPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVN 449
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIA----NQQDV 726
D A S VKEN+ IF + V + + ++ +
Sbjct: 450 DNAPAF---AQSEYTVFVKENNPPGC--HIFTVSARDADAQENALVSYSLVERRLGERSL 504
Query: 727 TDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP 785
+ +++ AE G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 505 SSYVSVHAESGKVYALQPLDHEELELLQFQVSAR-DAGVPPLGSNVTLQVFVLDENDNAP 563
Query: 786 VF---EHATYEGFIMEN--SKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM---F 837
+G + E +G + + ++A DAD G NA Y L E F
Sbjct: 564 ALLTPRMRGTDGAVSEMVLRSVGAGVVVGK-VRAVDADSGYNAWLSYELQPETASASIPF 622
Query: 838 DVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMI 883
V TG + +LD +L ++ +D G + A +++
Sbjct: 623 RVGLYTGEIS-TTRALDETDAPRQRLLVLVKDHGEPALTATATVLV 667
Score = 85.4 bits (202), Expect = 1e-15
Identities = 117/480 (24%), Positives = 187/480 (38%), Gaps = 40/480 (8%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +V+V + D NDN PVF P+ + + + + A D D+G
Sbjct: 105 HLEVIVDRPLQVFHVDVEVKDINDNPPVF-PATQKNLFIAESRPLDSRFPLEGASDADIG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHA----LFVEASDQPANPS 546
+N ++ Y L + P N + + +L+ L + A+D
Sbjct: 164 ENALLTYRLSPNEYFFLDVPTS-NQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPEL 222
Query: 547 ERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QN 604
L + ++ N + P F Y + NV IGT V +D E
Sbjct: 223 TGTVQLLITVLD-------NNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNG 275
Query: 605 DVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQEN-ANLSIVTN 661
D+ Y + F ++ SG ITV+ + + A+ + L+
Sbjct: 276 DIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCT 335
Query: 662 ATVHVVDVNDERGVL-LKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFL 719
V VVDVND L +K P VKE++ G I I ++ + + G V
Sbjct: 336 LLVEVVDVNDNAPQLTIKTLSVP----VKEDAQLGTVIALI---SVIDLDADANGQVTCS 388
Query: 720 IANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIED 779
+ ++ + LDRE Y + V A + G S +V++ + D
Sbjct: 389 LTPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTAR-DGGSPSLWATARVSVEVAD 447
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGK- 834
NDN P F + Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 448 VNDNAPAFAQSEYTVFVKENNPPGCHIFT---VSARDADAQENALVSYSLVERRLGERSL 504
Query: 835 -EMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 505 SSYVSVHAESGKVYAL-QPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAP 563
Score = 64.1 bits (149), Expect = 4e-09
Identities = 62/221 (28%), Positives = 96/221 (43%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y +
Sbjct: 443 VEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYS------LVE 496
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG--NLNDNISVRVF 1034
+L +L Y ++ G V + L E + +SA D G L N++++VF
Sbjct: 497 RRLGERSL--SSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVF 554
Query: 1035 VKDVNDHFP-VFKKTWYNFNVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQP- 1086
V D ND+ P + + ++ R V+GKV A DAD G NA L+Y +QP
Sbjct: 555 VLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPE 614
Query: 1087 -SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+ +PF + TG +S LD + L V+ +D+G
Sbjct: 615 TASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHG 655
Score = 62.1 bits (144), Expect = 1e-08
Identities = 50/154 (32%), Positives = 70/154 (45%), Gaps = 16/154 (10%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGS-----LFLEKELDLDAEHNLQANTFVL 274
A D D+G A L Y L S N+ + + N L L K LD + L L
Sbjct: 157 ASDADIGENALLTYRL-SPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELH-----L 210
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A+ P T ++ I +LD NDN P F+ Y + + EN+ G V+ A+D D
Sbjct: 211 LLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLD 270
Query: 335 QGENGEFTYQLD-----DPKGAFSIDPRSGWLTV 363
+G NG+ Y D K F +DP SG +TV
Sbjct: 271 EGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITV 304
Score = 58.4 bits (135), Expect = 2e-07
Identities = 71/290 (24%), Positives = 114/290 (39%), Gaps = 18/290 (6%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L G +++ + + + + D NDN P+F T Y V + E G + +
Sbjct: 212 LTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDE 271
Query: 127 SLTIPLTVPRGLTIFKDIRA-FDRDKPNTPNSDVHYSIVSGNDDGHFALESSHK--PVL- 182
L + + DI++ F D + + + + + +E+ K P L
Sbjct: 272 GLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLA 331
Query: 183 ----LLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPI---HAIDQDLGVGATLRYEL 235
LL +V+D + D QL I + ++ I ID D + L
Sbjct: 332 GHCTLLVEVVDVN--DNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSL 389
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIE 295
KL S SL L++ LD ++ + + L V A +P A ARV +E
Sbjct: 390 TPHVPFKLVSTYKNYYSLVLDRALDRES-----VSAYELVVTARDGGSPSLWATARVSVE 444
Query: 296 LLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+ D+NDN P F Y + + EN P G + V A D D EN +Y L
Sbjct: 445 VADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL 494
Score = 56.4 bits (130), Expect = 7e-07
Identities = 77/344 (22%), Positives = 143/344 (41%), Gaps = 41/344 (11%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPT--------------GEKAFIFLIAPIGPSL 128
V V ++D+NDN P+F T ++ + E P GE A L + P+
Sbjct: 119 VDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENAL--LTYRLSPNE 176
Query: 129 TIPLTVPRGLTIFKDIRAFDR---DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR 185
L VP K + R D+ TP ++H +++ D G L + V LL
Sbjct: 177 YFFLDVPTSNQQVKPLGLVLRKLLDREETP--ELHL-LLTATDGGKPELTGT---VQLLI 230
Query: 186 KVLDYDAG----DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL---ISG 238
VLD + D+ V + I ++ P +A D D G+ + Y +S
Sbjct: 231 TVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHP---NASDLDEGLNGDIIYSFSSDVSP 287
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
+ + F +D ++G++ + +D + ++ + V+A P + +E++D
Sbjct: 288 DIKSKFHMDPLSGAITVIGHMDFE-----ESRAHKIPVEAVDKGFPPLAGHCTLLVEVVD 342
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRS 358
+NDN P+ + ++ + E+ G + + D D NG+ T L +
Sbjct: 343 VNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYK 402
Query: 359 GWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGTFADSQRIA 401
+ ++ LDRE+ S+ + V A++ +PS+ T S +A
Sbjct: 403 NYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVA 446
Score = 54.0 bits (124), Expect = 4e-06
Identities = 62/219 (28%), Positives = 96/219 (43%), Gaps = 23/219 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ E+ +GT I ++ +DLD+ NGQ+ V P KL + K Y+ +
Sbjct: 359 VKEDAQLGTVIALISVIDLDADANGQVTCSLTPHV---PFKLVST---YKNYYSL----- 407
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
++ R+L ES + L ++A DGG+ L V V V DVND+ P F ++ Y V+
Sbjct: 408 --VLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVK 465
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTDLPFEIS--PLTGVLSVNGELDR 1110
E + V A DAD +NA ++Y + + + L +S +G + LD
Sbjct: 466 ENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDH 525
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
E + V ARD G D NDN+P
Sbjct: 526 EELELLQFQVSARDAG-VPPLGSNVTLQVFVLDENDNAP 563
Score = 52.8 bits (121), Expect = 9e-06
Identities = 55/205 (26%), Positives = 90/205 (43%), Gaps = 13/205 (6%)
Query: 700 IFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAE-----DGTIFTQKPLDREKRDVYRM 754
+ H N S + G++ + ++ DV+ DI G I +D E+ +++
Sbjct: 261 VIHPNASDLDEGLNGDIIYSFSS--DVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKI 318
Query: 755 TVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKA 814
V A +KG AG + + + D NDN P T + E++++GT I + ++I
Sbjct: 319 PVEA-VDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDL 377
Query: 815 TDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLS 874
DAD T K + +V + +LDRE Y+L + ARD G S
Sbjct: 378 -DADANGQVTCSLTPHVPFKLVSTYKNYYSLV--LDRALDRESVSAYELVVTARDGGSPS 434
Query: 875 --SEAELIIMIGDENDNKPEFNQIE 897
+ A + + + D NDN P F Q E
Sbjct: 435 LWATARVSVEVADVNDNAPAFAQSE 459
Score = 48.0 bits (109), Expect = 3e-04
Identities = 56/184 (30%), Positives = 85/184 (46%), Gaps = 17/184 (9%)
Query: 221 IDQDLGVG-ATL---RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQ 275
I QDLG+ A L ++L S L ++ NG LF+ +D + A + L+
Sbjct: 48 IAQDLGLELAELVPRLFQLDSKGRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLE 107
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
V ++ PL+ V++E+ D+NDN P F N+ I E+ P A+D D
Sbjct: 108 VI---VDRPLQVFH--VDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADI 162
Query: 336 GENGEFTYQLDDPKGAFSID-PRSGW----LTVRNQTVLDREAHSSLRMKVYAKE-TNPS 389
GEN TY+L P F +D P S L + + +LDRE L + + A + P
Sbjct: 163 GENALLTYRL-SPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPE 221
Query: 390 VVGT 393
+ GT
Sbjct: 222 LTGT 225
Score = 42.7 bits (96), Expect = 0.010
Identities = 40/156 (25%), Positives = 72/156 (46%), Gaps = 24/156 (15%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++TV D D + PVF Y +++ ENV+ ++ N ++ E
Sbjct: 218 GKPELTGTVQLLITVLDNND-----NAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
N + Y ++ DI+ F +DP +G + ++ D E +++ V A + +
Sbjct: 273 LNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFP---- 328
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
P+A ++V + DVNDN+P+ T
Sbjct: 329 ----PLAG---------HCTLLVEVVDVNDNAPQLT 351
Score = 42.3 bits (95), Expect = 0.013
Identities = 81/347 (23%), Positives = 135/347 (38%), Gaps = 30/347 (8%)
Query: 70 IGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEK----AFIFLIAPIG 125
+ G ++ + ++ V + DVNDN P V V E G + I L A
Sbjct: 323 VDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADAN 382
Query: 126 PSLTIPLT--VPRGL-TIFKDIRAFDRDKPNTPNSDVHYS-IVSGNDDGHFALESSHKPV 181
+T LT VP L + +K+ + D+ S Y +V+ D G +L ++ +
Sbjct: 383 GQVTCSLTPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVS 442
Query: 182 LLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGN-- 239
+ + V D + + + +F + A D D A + Y L+
Sbjct: 443 VEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFT--VSARDADAQENALVSYSLVERRLG 500
Query: 240 DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
+R L S SV+ G ++ + LD + LQ QV A P + +++ +
Sbjct: 501 ERSLSSYVSVHAESGKVYALQPLDHEELELLQ-----FQVSARDAGVPPLGSNVTLQVFV 555
Query: 297 LDLNDNLPEFEVDFYN-----IS--IVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
LD NDN P +S ++ ++ G V +V A D D G N +Y+L
Sbjct: 556 LDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPET 615
Query: 350 GAFSIDPRSGWLT--VRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
+ SI R G T + LD R+ V K+ P++ T
Sbjct: 616 ASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHGEPALTAT 662
Score = 36.3 bits (80), Expect = 0.85
Identities = 20/62 (32%), Positives = 34/62 (54%), Gaps = 5/62 (8%)
Query: 1429 ERLSLNGLT-SPQATDSDIGINADIRYQILNEQAP----RFAIDPVSGTVRVVAALARDA 1483
E +S+ L P A+D D G+N DI Y ++ +P +F +DP+SG + V+ + +
Sbjct: 253 ENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEE 312
Query: 1484 GR 1485
R
Sbjct: 313 SR 314
>BC104802-1|AAI04803.1| 950|Homo sapiens protocadherin alpha 9
protein.
Length = 950
Score = 102 bits (245), Expect = 9e-21
Identities = 116/425 (27%), Positives = 173/425 (40%), Gaps = 56/425 (13%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
++G +F +DRE+ V ++ V + ++D NDNPPVF
Sbjct: 80 QNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFPATQKN 139
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
FI E+ + + ++ A+DAD G NAL Y L DV + VK +G
Sbjct: 140 LFIAESRPLDSRFPLEG---ASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLG--- 193
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
LV R EL +++ + KPE L GT
Sbjct: 194 -----------LVLRKLLDREETPELHLLLTATDGGKPE-----------------LTGT 225
Query: 914 AGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
+I V N A D+ +PEN+ IGT +I NA DLD GLNG I Y F+S+
Sbjct: 226 VQL-LITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSD 284
Query: 974 VYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNI 1029
V + ++K F ++ G + V + E ++ + A+D G L +
Sbjct: 285 V----------SPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHC 334
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
++ V V DVND+ P + V+E V+ + D D N +T + P
Sbjct: 335 TLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTP--- 391
Query: 1090 DLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+PF+ +S S ++ LDRE+ Y L V ARD G DVND
Sbjct: 392 HVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGG-SPSLWATARVSVEVADVND 450
Query: 1147 NSPKF 1151
N+P F
Sbjct: 451 NAPAF 455
Score = 92.3 bits (219), Expect = 1e-17
Identities = 116/466 (24%), Positives = 191/466 (40%), Gaps = 39/466 (8%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + +T+LD NDN PVF LY + N +GT++ A D D G NG ++Y
Sbjct: 221 ELTGTVQLLITVLDNNDNAPVF-DRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIY 279
Query: 498 DLQRTSNLTITSPFKINPNTGTVSV-AESPILEGR-HALFVEASDQPANPSERRYSLAVV 555
+ I S F ++P +G ++V E R H + VEA D+ P +L V
Sbjct: 280 SFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVE 339
Query: 556 TIEVTRGTKGNKPDIP-DFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGY 614
++V N P + + P V + +GT + I V D D + +
Sbjct: 340 VVDV----NDNAPQLTIKTLSVP----VKEDAQLGTVIALISVIDL--DADANGQVTCSL 389
Query: 615 EEGVPF-AVEERSGVITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVN 670
VPF V ++V D L R + Y+ A + +L +V V DVN
Sbjct: 390 TPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVN 449
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIA----NQQDV 726
D A S VKEN+ IF + V + + ++ +
Sbjct: 450 DNAPAF---AQSEYTVFVKENNPPGC--HIFTVSARDADAQENALVSYSLVERRLGERSL 504
Query: 727 TDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP 785
+ +++ AE G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 505 SSYVSVHAESGKVYALQPLDHEELELLQFQVSAR-DAGVPPLGSNVTLQVFVLDENDNAP 563
Query: 786 VF---EHATYEGFIMEN--SKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM---F 837
+G + E +G + + ++A DAD G NA Y L E F
Sbjct: 564 ALLTPRMRGTDGAVSEMVLRSVGAGVVVGK-VRAVDADSGYNAWLSYELQPETASASIPF 622
Query: 838 DVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMI 883
V TG + +LD +L ++ +D G + A +++
Sbjct: 623 RVGLYTGEIS-TTRALDETDAPRQRLLVLVKDHGEPALTATATVLV 667
Score = 85.4 bits (202), Expect = 1e-15
Identities = 117/480 (24%), Positives = 187/480 (38%), Gaps = 40/480 (8%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +V+V + D NDN PVF P+ + + + + A D D+G
Sbjct: 105 HLEVIVDRPLQVFHVDVEVKDINDNPPVF-PATQKNLFIAESRPLDSRFPLEGASDADIG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHA----LFVEASDQPANPS 546
+N ++ Y L + P N + + +L+ L + A+D
Sbjct: 164 ENALLTYRLSPNEYFFLDVPTS-NQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPEL 222
Query: 547 ERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QN 604
L + ++ N + P F Y + NV IGT V +D E
Sbjct: 223 TGTVQLLITVLD-------NNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNG 275
Query: 605 DVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQEN-ANLSIVTN 661
D+ Y + F ++ SG ITV+ + + A+ + L+
Sbjct: 276 DIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCT 335
Query: 662 ATVHVVDVNDERGVL-LKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFL 719
V VVDVND L +K P VKE++ G I I ++ + + G V
Sbjct: 336 LLVEVVDVNDNAPQLTIKTLSVP----VKEDAQLGTVIALI---SVIDLDADANGQVTCS 388
Query: 720 IANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIED 779
+ ++ + LDRE Y + V A + G S +V++ + D
Sbjct: 389 LTPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTAR-DGGSPSLWATARVSVEVAD 447
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGK- 834
NDN P F + Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 448 VNDNAPAFAQSEYTVFVKENNPPGCHIFT---VSARDADAQENALVSYSLVERRLGERSL 504
Query: 835 -EMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 505 SSYVSVHAESGKVYAL-QPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAP 563
Score = 64.1 bits (149), Expect = 4e-09
Identities = 62/221 (28%), Positives = 96/221 (43%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y +
Sbjct: 443 VEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYS------LVE 496
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG--NLNDNISVRVF 1034
+L +L Y ++ G V + L E + +SA D G L N++++VF
Sbjct: 497 RRLGERSL--SSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVF 554
Query: 1035 VKDVNDHFP-VFKKTWYNFNVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQP- 1086
V D ND+ P + + ++ R V+GKV A DAD G NA L+Y +QP
Sbjct: 555 VLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPE 614
Query: 1087 -SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+ +PF + TG +S LD + L V+ +D+G
Sbjct: 615 TASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHG 655
Score = 62.1 bits (144), Expect = 1e-08
Identities = 50/154 (32%), Positives = 70/154 (45%), Gaps = 16/154 (10%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGS-----LFLEKELDLDAEHNLQANTFVL 274
A D D+G A L Y L S N+ + + N L L K LD + L L
Sbjct: 157 ASDADIGENALLTYRL-SPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELH-----L 210
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A+ P T ++ I +LD NDN P F+ Y + + EN+ G V+ A+D D
Sbjct: 211 LLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLD 270
Query: 335 QGENGEFTYQLD-----DPKGAFSIDPRSGWLTV 363
+G NG+ Y D K F +DP SG +TV
Sbjct: 271 EGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITV 304
Score = 58.4 bits (135), Expect = 2e-07
Identities = 71/290 (24%), Positives = 114/290 (39%), Gaps = 18/290 (6%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L G +++ + + + + D NDN P+F T Y V + E G + +
Sbjct: 212 LTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDE 271
Query: 127 SLTIPLTVPRGLTIFKDIRA-FDRDKPNTPNSDVHYSIVSGNDDGHFALESSHK--PVL- 182
L + + DI++ F D + + + + + +E+ K P L
Sbjct: 272 GLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLA 331
Query: 183 ----LLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPI---HAIDQDLGVGATLRYEL 235
LL +V+D + D QL I + ++ I ID D + L
Sbjct: 332 GHCTLLVEVVDVN--DNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSL 389
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIE 295
KL S SL L++ LD ++ + + L V A +P A ARV +E
Sbjct: 390 TPHVPFKLVSTYKNYYSLVLDRALDRES-----VSAYELVVTARDGGSPSLWATARVSVE 444
Query: 296 LLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+ D+NDN P F Y + + EN P G + V A D D EN +Y L
Sbjct: 445 VADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL 494
Score = 56.4 bits (130), Expect = 7e-07
Identities = 77/344 (22%), Positives = 143/344 (41%), Gaps = 41/344 (11%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPT--------------GEKAFIFLIAPIGPSL 128
V V ++D+NDN P+F T ++ + E P GE A L + P+
Sbjct: 119 VDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENAL--LTYRLSPNE 176
Query: 129 TIPLTVPRGLTIFKDIRAFDR---DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR 185
L VP K + R D+ TP ++H +++ D G L + V LL
Sbjct: 177 YFFLDVPTSNQQVKPLGLVLRKLLDREETP--ELHL-LLTATDGGKPELTGT---VQLLI 230
Query: 186 KVLDYDAG----DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL---ISG 238
VLD + D+ V + I ++ P +A D D G+ + Y +S
Sbjct: 231 TVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHP---NASDLDEGLNGDIIYSFSSDVSP 287
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
+ + F +D ++G++ + +D + ++ + V+A P + +E++D
Sbjct: 288 DIKSKFHMDPLSGAITVIGHMDFE-----ESRAHKIPVEAVDKGFPPLAGHCTLLVEVVD 342
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRS 358
+NDN P+ + ++ + E+ G + + D D NG+ T L +
Sbjct: 343 VNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYK 402
Query: 359 GWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGTFADSQRIA 401
+ ++ LDRE+ S+ + V A++ +PS+ T S +A
Sbjct: 403 NYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVA 446
Score = 54.0 bits (124), Expect = 4e-06
Identities = 62/219 (28%), Positives = 96/219 (43%), Gaps = 23/219 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ E+ +GT I ++ +DLD+ NGQ+ V P KL + K Y+ +
Sbjct: 359 VKEDAQLGTVIALISVIDLDADANGQVTCSLTPHV---PFKLVST---YKNYYSL----- 407
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
++ R+L ES + L ++A DGG+ L V V V DVND+ P F ++ Y V+
Sbjct: 408 --VLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVK 465
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTDLPFEIS--PLTGVLSVNGELDR 1110
E + V A DAD +NA ++Y + + + L +S +G + LD
Sbjct: 466 ENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDH 525
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
E + V ARD G D NDN+P
Sbjct: 526 EELELLQFQVSARDAG-VPPLGSNVTLQVFVLDENDNAP 563
Score = 52.8 bits (121), Expect = 9e-06
Identities = 55/205 (26%), Positives = 90/205 (43%), Gaps = 13/205 (6%)
Query: 700 IFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAE-----DGTIFTQKPLDREKRDVYRM 754
+ H N S + G++ + ++ DV+ DI G I +D E+ +++
Sbjct: 261 VIHPNASDLDEGLNGDIIYSFSS--DVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKI 318
Query: 755 TVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKA 814
V A +KG AG + + + D NDN P T + E++++GT I + ++I
Sbjct: 319 PVEA-VDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDL 377
Query: 815 TDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLS 874
DAD T K + +V + +LDRE Y+L + ARD G S
Sbjct: 378 -DADANGQVTCSLTPHVPFKLVSTYKNYYSLV--LDRALDRESVSAYELVVTARDGGSPS 434
Query: 875 --SEAELIIMIGDENDNKPEFNQIE 897
+ A + + + D NDN P F Q E
Sbjct: 435 LWATARVSVEVADVNDNAPAFAQSE 459
Score = 48.0 bits (109), Expect = 3e-04
Identities = 56/184 (30%), Positives = 85/184 (46%), Gaps = 17/184 (9%)
Query: 221 IDQDLGVG-ATL---RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQ 275
I QDLG+ A L ++L S L ++ NG LF+ +D + A + L+
Sbjct: 48 IAQDLGLELAELVPRLFQLDSKGRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLE 107
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
V ++ PL+ V++E+ D+NDN P F N+ I E+ P A+D D
Sbjct: 108 VI---VDRPLQVFH--VDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADI 162
Query: 336 GENGEFTYQLDDPKGAFSID-PRSGW----LTVRNQTVLDREAHSSLRMKVYAKE-TNPS 389
GEN TY+L P F +D P S L + + +LDRE L + + A + P
Sbjct: 163 GENALLTYRL-SPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPE 221
Query: 390 VVGT 393
+ GT
Sbjct: 222 LTGT 225
Score = 42.7 bits (96), Expect = 0.010
Identities = 40/156 (25%), Positives = 72/156 (46%), Gaps = 24/156 (15%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++TV D D + PVF Y +++ ENV+ ++ N ++ E
Sbjct: 218 GKPELTGTVQLLITVLDNND-----NAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
N + Y ++ DI+ F +DP +G + ++ D E +++ V A + +
Sbjct: 273 LNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFP---- 328
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
P+A ++V + DVNDN+P+ T
Sbjct: 329 ----PLAG---------HCTLLVEVVDVNDNAPQLT 351
Score = 42.3 bits (95), Expect = 0.013
Identities = 81/347 (23%), Positives = 135/347 (38%), Gaps = 30/347 (8%)
Query: 70 IGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEK----AFIFLIAPIG 125
+ G ++ + ++ V + DVNDN P V V E G + I L A
Sbjct: 323 VDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADAN 382
Query: 126 PSLTIPLT--VPRGL-TIFKDIRAFDRDKPNTPNSDVHYS-IVSGNDDGHFALESSHKPV 181
+T LT VP L + +K+ + D+ S Y +V+ D G +L ++ +
Sbjct: 383 GQVTCSLTPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVS 442
Query: 182 LLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGN-- 239
+ + V D + + + +F + A D D A + Y L+
Sbjct: 443 VEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFT--VSARDADAQENALVSYSLVERRLG 500
Query: 240 DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
+R L S SV+ G ++ + LD + LQ QV A P + +++ +
Sbjct: 501 ERSLSSYVSVHAESGKVYALQPLDHEELELLQ-----FQVSARDAGVPPLGSNVTLQVFV 555
Query: 297 LDLNDNLPEFEVDFYN-----IS--IVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
LD NDN P +S ++ ++ G V +V A D D G N +Y+L
Sbjct: 556 LDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPET 615
Query: 350 GAFSIDPRSGWLT--VRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
+ SI R G T + LD R+ V K+ P++ T
Sbjct: 616 ASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHGEPALTAT 662
Score = 36.3 bits (80), Expect = 0.85
Identities = 20/62 (32%), Positives = 34/62 (54%), Gaps = 5/62 (8%)
Query: 1429 ERLSLNGLT-SPQATDSDIGINADIRYQILNEQAP----RFAIDPVSGTVRVVAALARDA 1483
E +S+ L P A+D D G+N DI Y ++ +P +F +DP+SG + V+ + +
Sbjct: 253 ENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEE 312
Query: 1484 GR 1485
R
Sbjct: 313 SR 314
>AY563166-1|AAT72166.1| 1079|Homo sapiens cadherin 23 isoform B2
protein.
Length = 1079
Score = 102 bits (245), Expect = 9e-21
Identities = 133/488 (27%), Positives = 208/488 (42%), Gaps = 51/488 (10%)
Query: 430 ENIEYYDEQLMSFVNVEVTL--LDANDNNPVFVPSNL--YEFSMKSNAKVGTVIGKVKAV 485
+N E+ +S N ++T+ LD NDN P F P + Y + A GT + V AV
Sbjct: 22 DNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAV 81
Query: 486 DPDLGQNGMVLYDLQRTSNLTITSPFKI---NPNTGTVSVAESPILEGRHAL--FVEASD 540
DPD G NG+V Y L L + P + + + G V + E H L V ASD
Sbjct: 82 DPDKGLNGLVTYTL-----LDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASD 136
Query: 541 QPANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA 600
N S R + V +E+ N P F Y+ V +V +GT + + DA
Sbjct: 137 ---NGSPPRAAEIPVYLEIVDINDNN----PIFDQPSYQEAVFEDVPVGTIILTVTATDA 189
Query: 601 FEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSI-- 658
N + G E FA+ +G I V+ L R + Y A+A +++
Sbjct: 190 DSGNFALIEYSLGDGES-KFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNR 248
Query: 659 ---VTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGN 715
+ V+DVND R K S ++ + AG ++ + T+ G
Sbjct: 249 RENSVQVVIQVLDVNDCRPQFSKPQFSTSVY--ENEPAGTSVITMMATDQDE---GPNGE 303
Query: 716 VRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTI 775
+ + + + + + G + TQ+PL + + + +TV+A + G G + +
Sbjct: 304 LTYSLEGPGVEAFHVDM-DSGLVTTQRPL--QSYEKFSLTVVAT-DGGEPPLWGTTMLLV 359
Query: 776 YIEDENDNPPVFEHATYEGFIMENSKIGTEIKM-DNI--IKATDADEGTNAL----FMYT 828
+ D NDN PVF G I+ I EI + N+ + ATD DEG N F+ T
Sbjct: 360 EVIDVNDNRPVFVRPP-NGTILH---IREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKT 415
Query: 829 LFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG---GLSSEAELIIMIGD 885
E F +D +G+++ LDRE + +Y L LVA D G + L + + D
Sbjct: 416 AGNRDWEFFIIDPISGLIQ-TAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALED 474
Query: 886 ENDNKPEF 893
+DN+P F
Sbjct: 475 IDDNEPLF 482
Score = 97.9 bits (233), Expect = 2e-19
Identities = 125/494 (25%), Positives = 202/494 (40%), Gaps = 69/494 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I E GTT+I + A+D D GLNG + Y +PP + + + G
Sbjct: 65 ILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLD--LVPPGYVQLE----------DSSAG 112
Query: 1000 HVIVARSLPPESEFRLN--ISALDGGNLNDNISVRVFVK--DVNDHFPVFKKTWYNFNVE 1055
VI R++ E LN + A D G+ + V+++ D+ND+ P+F + Y V
Sbjct: 113 KVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVF 172
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E ++ V ATDAD G A + Y + D + F I+P TG + V LDRE +D
Sbjct: 173 EDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLDREKKDH 230
Query: 1116 YILTVVARDNG---XXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHN 1172
YILT +A+DN DVND P+F P+ N
Sbjct: 231 YILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQF---------SKPQFSTSVYEN 281
Query: 1173 FESVMMIPVYKATIEENAPIGTTVAKVFANDTD--FIGNGNGLILYSLPQRKNQQ----- 1225
+ + AT ++ P G + + + +GL+ P + ++
Sbjct: 282 EPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTV 341
Query: 1226 ---NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFI--SRYYELEIEENVNAPVELVSLN 1280
+ G P L T +L+V V DV D ++PVF+ L I E + + +
Sbjct: 342 VATDGGEPPLWGTTMLLVEVIDVND-----NRPVFVRPPNGTILHIREEIPLRSNVYEVY 396
Query: 1281 LTEHYE--NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
T+ E N +RY L F+IDP +G + + DRE + Y +I+ A
Sbjct: 397 ATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS-- 454
Query: 1339 KYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT----NGNRPLVTAIPTT 1394
+ PV + ++ + V ++D++DN P F + + +P
Sbjct: 455 -------DLGQPVPYETMQPLQ-------VALEDIDDNEPLFVRPPKGSPQYQLLTVPEH 500
Query: 1395 APFGYQVMQLKGAI 1408
+P G V + GA+
Sbjct: 501 SPRGTLVGNVTGAV 514
Score = 87.8 bits (208), Expect = 3e-16
Identities = 74/253 (29%), Positives = 114/253 (45%), Gaps = 20/253 (7%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
+ +VD+ND + + ++ +F ++ G I + T+ S GN + +
Sbjct: 150 LEIVDINDNNPIFDQPSYQEAVF--EDVPVGTIILTVTATDADS------GNFALIEYSL 201
Query: 724 QDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG---AGIYQVTIYIED 779
D AI G I+ LDREK+D Y +T +A+ N G ++ QV I + D
Sbjct: 202 GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLD 261
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDV 839
ND P F + + EN GT + + ATD DEG N Y+L G G E F V
Sbjct: 262 VNDCRPQFSKPQFSTSVYENEPAGTSVIT---MMATDQDEGPNGELTYSLEGPGVEAFHV 318
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIE 897
D ++G+V EK + L++VA D G L L++ + D NDN+P F +
Sbjct: 319 DMDSGLVTTQRPLQSYEK---FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPP 375
Query: 898 ENSKVRIHRETKL 910
+ + I E L
Sbjct: 376 NGTILHIREEIPL 388
Score = 81.4 bits (192), Expect = 2e-14
Identities = 113/492 (22%), Positives = 204/492 (41%), Gaps = 54/492 (10%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + +LD ND P F + S+ N GT + + A D D G NG + Y L+
Sbjct: 253 VQVVIQVLDVNDCRPQFSKPQ-FSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGP 311
Query: 503 SNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F ++ ++G V+ + +L V A+D P L V I+V
Sbjct: 312 G----VEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVN-- 365
Query: 563 TKGNKPDIPDFMGAPYE--FWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLH--GYEE 616
N+P F+ P + + + ++V ++ D E V Y L G +
Sbjct: 366 --DNRPV---FVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRD 420
Query: 617 GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV--DVNDERG 674
F ++ SG+I L R ++ +Y VA + T + V D++D
Sbjct: 421 WEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEP 480
Query: 675 VLL---KGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
+ + KG+ + V E+S G +G + + + G F+ A ++ +
Sbjct: 481 LFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGA-VDADEGPNAIVYYFIAAGNEE--KNF 537
Query: 731 AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKG------------VISGAGIYQVTIYIE 778
+ DG + + LDRE+ ++ V A N+ +++ + +V + +E
Sbjct: 538 HLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLE 597
Query: 779 DENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG--EGKEM 836
D ND PP F A Y + ++K+G+E+ + A DAD G N+L Y++ + +
Sbjct: 598 DINDQPPRFTKAEYTAGVATDAKVGSELIQ---VLALDADIGNNSLVFYSILAIHYFRAL 654
Query: 837 FDVDENTGVVKFIG--DSLDREKKIM-------YKLSLVARDTGGLSSEAEL-IIMIGDE 886
+ E+ G V +G D + R + + + +VARD G + A + I ++ D+
Sbjct: 655 ANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDD 714
Query: 887 NDNKPEFNQIEE 898
K N+I +
Sbjct: 715 QRVKIVINEIPD 726
Score = 80.6 bits (190), Expect = 4e-14
Identities = 47/148 (31%), Positives = 78/148 (52%), Gaps = 4/148 (2%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G A + Y L G + F+++ G +++ LD + + +
Sbjct: 184 VTATDADSGNFALIEYSLGDGESK--FAINPTTGDIYVLSSLDREKKDHYILTALAKDNP 241
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
+N + + +V I++LD+ND P+F ++ S+ EN P G SV+ +MATD+D+G
Sbjct: 242 GDVASNRRENS-VQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGP 300
Query: 338 NGEFTYQLDDP-KGAFSIDPRSGWLTVR 364
NGE TY L+ P AF +D SG +T +
Sbjct: 301 NGELTYSLEGPGVEAFHVDMDSGLVTTQ 328
Score = 80.2 bits (189), Expect = 5e-14
Identities = 128/492 (26%), Positives = 206/492 (41%), Gaps = 65/492 (13%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
E++P+GT I+ + A D DSG I Y E K F IN G +
Sbjct: 173 EDVPVGTIILTVTATDADSGNFALIEYSLGDG-------------ESK--FAINPTTGDI 217
Query: 1002 IVARSLPPESEFRLNISALDGGNLND--------NISVRVFVKDVNDHFPVFKKTWYNFN 1053
V SL E + ++AL N D ++ V + V DVND P F K ++ +
Sbjct: 218 YVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTS 277
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETE 1113
V E + + + ATD D G N LTY ++ + F + +G+++ L ++
Sbjct: 278 VYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA-FHVDMDSGLVTTQRPL--QSY 334
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNF 1173
+K+ LTVVA D G DVNDN P F E L ++ +
Sbjct: 335 EKFSLTVVATDGGEPPLWGTTMLLVEVI-DVNDNRPVFVRPPNGTILHIREEIPLRSNVY 393
Query: 1174 ESVMMIPVYKATIEE--NAPIGTTVAKVFAN-DTDF--IGNGNGLILYSLPQRKNQQ--- 1225
E VY +E N + + K N D +F I +GLI + + Q
Sbjct: 394 E------VYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY 447
Query: 1226 -------NLGLPSLSSTAI-LMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELV 1277
+LG P T L V + D+ D + +P S Y+L + ++P +
Sbjct: 448 SLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQL-LTVPEHSPRGTL 506
Query: 1278 SLNLT-----EHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVI 1332
N+T + N + Y+I N+ + F + P +G L ++R DRE + + I
Sbjct: 507 VGNVTGAVDADEGPNAIVYYFIAAGNE---EKNFHLQP-DGCLLVLRDLDREREAIFSFI 562
Query: 1333 VRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIP 1392
V+A + S P P D++ +T +V+VV ++D+ND P+FT +
Sbjct: 563 VKASSNR-SWTPPRGPSPTL-DLVADLTLQEVRVV--LEDINDQPPRFTKAE--YTAGVA 616
Query: 1393 TTAPFGYQVMQL 1404
T A G +++Q+
Sbjct: 617 TDAKVGSELIQV 628
Score = 77.8 bits (183), Expect = 3e-13
Identities = 54/177 (30%), Positives = 86/177 (48%), Gaps = 9/177 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSL-DSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A+D D G+ + Y L+ L DS G + + +D + H L V
Sbjct: 78 VAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLN-----FTV 132
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+AS +P + A+ V +E++D+NDN P F+ Y ++ E++P G +L V ATD D G
Sbjct: 133 RASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSG 192
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
Y L D + F+I+P +G + V + LDRE + AK+ NP V +
Sbjct: 193 NFALIEYSLGDGESKFAINPTTGDIYVLSS--LDREKKDHYILTALAKD-NPGDVAS 246
Score = 74.5 bits (175), Expect = 3e-12
Identities = 73/237 (30%), Positives = 105/237 (44%), Gaps = 28/237 (11%)
Query: 929 LDVDQLGPLFLIP-------ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LDV+ P F P EN P GT++I + A D D G NG++ Y L
Sbjct: 260 LDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTY-----------SL 308
Query: 982 SADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVKDVN 1039
+E F ++ G V R L +F L + A DGG L + V V DVN
Sbjct: 309 EGPGVEA---FHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVN 365
Query: 1040 DHFPVFKK--TWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPS-DTDLP-FE 1094
D+ PVF + ++ E R + +V ATD D G N + Y F++ + + D F
Sbjct: 366 DNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFI 425
Query: 1095 ISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
I P++G++ LDRE++ Y L +VA D G D++DN P F
Sbjct: 426 IDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLF 482
Score = 61.7 bits (143), Expect = 2e-08
Identities = 59/203 (29%), Positives = 92/203 (45%), Gaps = 23/203 (11%)
Query: 935 GPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVI 994
G + I E IP+ + + ++ A D D GLNG +RY F L +F+I
Sbjct: 377 GTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSF----------LKTAGNRDWEFFII 426
Query: 995 NERHGHVIVARSLPPESE--FRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFKK-- 1047
+ G + A+ L ES+ + L + A D G ++V ++D++D+ P+F +
Sbjct: 427 DPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPP 486
Query: 1048 ----TWYNFNVEEAQYTRRVLGKV-DATDADFGQNANLTYFIQPSDTDLPFEISPLTGVL 1102
+ V E ++G V A DAD G NA + YFI + + F + P G L
Sbjct: 487 KGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCL 545
Query: 1103 SVNGELDRETEDKYILTVVARDN 1125
V +LDRE E + V A N
Sbjct: 546 LVLRDLDREREAIFSFIVKASSN 568
Score = 58.4 bits (135), Expect = 2e-07
Identities = 114/498 (22%), Positives = 199/498 (39%), Gaps = 50/498 (10%)
Query: 83 VTVYIE--DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI--APIGPSLTIPLTVPRGL 138
+ VY+E D+NDN PIF Y V E P G A G I ++ G
Sbjct: 146 IPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGE 205
Query: 139 TIFK------DI---RAFDRDKPNTPNSDVHYSI--VSGNDDGHFALESSHKPVLLLRKV 187
+ F DI + DR+K + HY + ++ ++ G A V ++ +V
Sbjct: 206 SKFAINPTTGDIYVLSSLDREKKD------HYILTALAKDNPGDVASNRRENSVQVVIQV 259
Query: 188 LDYDAGDKEFQLVIMASGKRIHKEI-LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSL 246
LD + +F ++ ++ + A DQD G L Y L G + F +
Sbjct: 260 LDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHV 318
Query: 247 DSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF 306
D +G + ++ L F L V A+ P + +E++D+NDN P F
Sbjct: 319 DMDSGLVTTQRPLQ-------SYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVF 371
Query: 307 --EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKG-----AFSIDPRSG 359
+ + I E +P +V +V ATDKD+G NG Y G F IDP SG
Sbjct: 372 VRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISG 431
Query: 360 WLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGTFADSQRIAKWRRQPLETNAPLEKTTY 419
+ + LDRE+ + + + A + V ++A + ++ N PL +
Sbjct: 432 LIQTAQR--LDRESQAVYSLILVASDLGQPVPYETMQPLQVA---LEDIDDNEPL----F 482
Query: 420 VFPDKVGTKTENIEYYDEQLMSFVNVEVT-LLDANDNNPVFVPSNLYEFSMKSNAKVGTV 478
V P K + + + + + VT +DA++ V + + + N +
Sbjct: 483 VRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD 542
Query: 479 IGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEA 538
+ D D + + + ++ +SN + T P +P T+ + L+ + +
Sbjct: 543 GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSP---TLDLVADLTLQEVRVVLEDI 599
Query: 539 SDQPANPSERRYSLAVVT 556
+DQP ++ Y+ V T
Sbjct: 600 NDQPPRFTKAEYTAGVAT 617
Score = 55.2 bits (127), Expect = 2e-06
Identities = 31/90 (34%), Positives = 49/90 (54%), Gaps = 5/90 (5%)
Query: 290 ARVEIELLDLNDNLPEFE---VDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
A++ + +LD+NDN P+F+ + +Y I+E G +++ V A D D+G NG TY L
Sbjct: 37 AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLL 96
Query: 347 D--PKGAFSIDPRSGWLTVRNQTVLDREAH 374
D P G ++ S + N+TV E H
Sbjct: 97 DLVPPGYVQLEDSSAGKVIANRTVDYEEVH 126
Score = 49.2 bits (112), Expect = 1e-04
Identities = 79/323 (24%), Positives = 135/323 (41%), Gaps = 34/323 (10%)
Query: 81 LSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIA--PIGPS--LTIPLTVP- 135
+ V + + DVND P F + +V E P G + GP+ LT L P
Sbjct: 253 VQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPG 312
Query: 136 -RGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
+ D +P ++V+ D G L + +LL +V+D +
Sbjct: 313 VEAFHVDMDSGLVTTQRPLQSYEKFSLTVVA-TDGGEPPLWGT---TMLLVEVIDVNDNR 368
Query: 195 KEFQLVIMASGKRIHKEILFPE---PIHAIDQDLGVGATLRYELI--SGN-DRKLFSLDS 248
F + I +EI ++A D+D G+ +RY + +GN D + F +D
Sbjct: 369 PVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDP 428
Query: 249 VNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPL--KTAQARVEIELLDLNDNLPEF 306
++G + + LD +++ + L + AS L P+ +T Q +++ L D++DN P F
Sbjct: 429 ISGLIQTAQRLDRESQ-----AVYSLILVASDLGQPVPYETMQP-LQVALEDIDDNEPLF 482
Query: 307 ------EVDFYNISIVENLPNGFSVLQVM-ATDKDQGENGEFTYQL--DDPKGAFSIDPR 357
+ +++ E+ P G V V A D D+G N Y + + + F + P
Sbjct: 483 VRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP- 541
Query: 358 SGWLTVRNQTVLDREAHSSLRMK 380
G L V +REA S +K
Sbjct: 542 DGCLLVLRDLDREREAIFSFIVK 564
Score = 46.8 bits (106), Expect = 6e-04
Identities = 45/165 (27%), Positives = 74/165 (44%), Gaps = 13/165 (7%)
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIY----QVTIYIEDENDNPPVFEH---ATYE 793
+ P++RE Y +T+ N + + ++T+ + D NDN P F+ Y
Sbjct: 3 KSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYM 62
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD-S 852
I+E + GT + + A D D+G N L YTL + E++ K I + +
Sbjct: 63 ERILEGATPGTTLIA---VAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRT 119
Query: 853 LDREKKIMYKLSLVARDTGGLSSEAELIIM--IGDENDNKPEFNQ 895
+D E+ ++ A D G AE+ + I D NDN P F+Q
Sbjct: 120 VDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQ 164
Score = 45.2 bits (102), Expect = 0.002
Identities = 35/137 (25%), Positives = 61/137 (44%), Gaps = 15/137 (10%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G A + Y + +GN+ K F L +G L + ++LD + E +F+++ ++
Sbjct: 513 AVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIF---SFIVKASSN 568
Query: 280 QLNNPLKTAQA-----------RVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQV 328
+ P + V + L D+ND P F Y + + G ++QV
Sbjct: 569 RSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQV 628
Query: 329 MATDKDQGENGEFTYQL 345
+A D D G N Y +
Sbjct: 629 LALDADIGNNSLVFYSI 645
Score = 40.7 bits (91), Expect = 0.039
Identities = 58/199 (29%), Positives = 75/199 (37%), Gaps = 41/199 (20%)
Query: 1028 NISVRVFVKDVNDHFPVFKK---TWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
N + V V DVND+ P FK T+Y + E L V A D D G N +TY
Sbjct: 36 NAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTL 95
Query: 1083 --FIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXX 1140
+ P L G + N +D E TV A DNG
Sbjct: 96 LDLVPPGYVQLE---DSSAGKVIANRTVDYEEVHWLNFTVRASDNG-SPPRAAEIPVYLE 151
Query: 1141 XXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVF 1200
D+NDN+P FD+ P Y+ + E+ P+GT + V
Sbjct: 152 IVDINDNNP---IFDQ-----------------------PSYQEAVFEDVPVGTIILTVT 185
Query: 1201 ANDTDFIGNGN-GLILYSL 1218
A D D +GN LI YSL
Sbjct: 186 ATDAD---SGNFALIEYSL 201
Score = 40.7 bits (91), Expect = 0.039
Identities = 40/151 (26%), Positives = 67/151 (44%), Gaps = 12/151 (7%)
Query: 79 AYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS----LTIPLTV 134
A S+ + D+ VP P V ++++ + +F+ P G LT+P
Sbjct: 445 AVYSLILVASDLGQPVPYETMQPLQVALEDID---DNEPLFVRPPKGSPQYQLLTVPEHS 501
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
PRG + A D D+ PN+ V+Y I +GN++ +F L+ LL+ + LD + +
Sbjct: 502 PRGTLVGNVTGAVDADEG--PNAIVYYFIAAGNEEKNFHLQPD--GCLLVLRDLDRER-E 556
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAIDQDL 225
F ++ AS R P P + DL
Sbjct: 557 AIFSFIVKASSNRSWTPPRGPSPTLDLVADL 587
Score = 37.5 bits (83), Expect = 0.37
Identities = 19/51 (37%), Positives = 27/51 (52%), Gaps = 4/51 (7%)
Query: 1441 ATDSDIGINADIRYQILNEQAPR----FAIDPVSGTVRVVAALARDAGRVF 1487
ATD D G+N +RY L R F IDP+SG ++ L R++ V+
Sbjct: 397 ATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY 447
Score = 35.1 bits (77), Expect = 2.0
Identities = 21/54 (38%), Positives = 27/54 (50%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI 1084
VRV ++D+ND P F K Y V L +V A DAD G N+ + Y I
Sbjct: 592 VRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSI 645
>AY563165-1|AAT72165.1| 1114|Homo sapiens cadherin 23 isoform B1
protein.
Length = 1114
Score = 102 bits (245), Expect = 9e-21
Identities = 133/488 (27%), Positives = 208/488 (42%), Gaps = 51/488 (10%)
Query: 430 ENIEYYDEQLMSFVNVEVTL--LDANDNNPVFVPSNL--YEFSMKSNAKVGTVIGKVKAV 485
+N E+ +S N ++T+ LD NDN P F P + Y + A GT + V AV
Sbjct: 22 DNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAV 81
Query: 486 DPDLGQNGMVLYDLQRTSNLTITSPFKI---NPNTGTVSVAESPILEGRHAL--FVEASD 540
DPD G NG+V Y L L + P + + + G V + E H L V ASD
Sbjct: 82 DPDKGLNGLVTYTL-----LDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASD 136
Query: 541 QPANPSERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDA 600
N S R + V +E+ N P F Y+ V +V +GT + + DA
Sbjct: 137 ---NGSPPRAAEIPVYLEIVDINDNN----PIFDQPSYQEAVFEDVPVGTIILTVTATDA 189
Query: 601 FEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSI-- 658
N + G E FA+ +G I V+ L R + Y A+A +++
Sbjct: 190 DSGNFALIEYSLGDGES-KFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNR 248
Query: 659 ---VTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGN 715
+ V+DVND R K S ++ + AG ++ + T+ G
Sbjct: 249 RENSVQVVIQVLDVNDCRPQFSKPQFSTSVY--ENEPAGTSVITMMATDQDE---GPNGE 303
Query: 716 VRFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTI 775
+ + + + + + G + TQ+PL + + + +TV+A + G G + +
Sbjct: 304 LTYSLEGPGVEAFHVDM-DSGLVTTQRPL--QSYEKFSLTVVAT-DGGEPPLWGTTMLLV 359
Query: 776 YIEDENDNPPVFEHATYEGFIMENSKIGTEIKM-DNI--IKATDADEGTNAL----FMYT 828
+ D NDN PVF G I+ I EI + N+ + ATD DEG N F+ T
Sbjct: 360 EVIDVNDNRPVFVRPP-NGTILH---IREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKT 415
Query: 829 LFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG---GLSSEAELIIMIGD 885
E F +D +G+++ LDRE + +Y L LVA D G + L + + D
Sbjct: 416 AGNRDWEFFIIDPISGLIQ-TAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALED 474
Query: 886 ENDNKPEF 893
+DN+P F
Sbjct: 475 IDDNEPLF 482
Score = 97.9 bits (233), Expect = 2e-19
Identities = 125/494 (25%), Positives = 202/494 (40%), Gaps = 69/494 (13%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I E GTT+I + A+D D GLNG + Y +PP + + + G
Sbjct: 65 ILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLD--LVPPGYVQLE----------DSSAG 112
Query: 1000 HVIVARSLPPESEFRLN--ISALDGGNLNDNISVRVFVK--DVNDHFPVFKKTWYNFNVE 1055
VI R++ E LN + A D G+ + V+++ D+ND+ P+F + Y V
Sbjct: 113 KVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVF 172
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDK 1115
E ++ V ATDAD G A + Y + D + F I+P TG + V LDRE +D
Sbjct: 173 EDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLDREKKDH 230
Query: 1116 YILTVVARDNG---XXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHN 1172
YILT +A+DN DVND P+F P+ N
Sbjct: 231 YILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQF---------SKPQFSTSVYEN 281
Query: 1173 FESVMMIPVYKATIEENAPIGTTVAKVFANDTD--FIGNGNGLILYSLPQRKNQQ----- 1225
+ + AT ++ P G + + + +GL+ P + ++
Sbjct: 282 EPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTV 341
Query: 1226 ---NLGLPSLSSTAILMVTVADVPDEVEMSDKPVFI--SRYYELEIEENVNAPVELVSLN 1280
+ G P L T +L+V V DV D ++PVF+ L I E + + +
Sbjct: 342 VATDGGEPPLWGTTMLLVEVIDVND-----NRPVFVRPPNGTILHIREEIPLRSNVYEVY 396
Query: 1281 LTEHYE--NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
T+ E N +RY L F+IDP +G + + DRE + Y +I+ A
Sbjct: 397 ATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS-- 454
Query: 1339 KYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT----NGNRPLVTAIPTT 1394
+ PV + ++ + V ++D++DN P F + + +P
Sbjct: 455 -------DLGQPVPYETMQPLQ-------VALEDIDDNEPLFVRPPKGSPQYQLLTVPEH 500
Query: 1395 APFGYQVMQLKGAI 1408
+P G V + GA+
Sbjct: 501 SPRGTLVGNVTGAV 514
Score = 87.8 bits (208), Expect = 3e-16
Identities = 74/253 (29%), Positives = 114/253 (45%), Gaps = 20/253 (7%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
+ +VD+ND + + ++ +F ++ G I + T+ S GN + +
Sbjct: 150 LEIVDINDNNPIFDQPSYQEAVF--EDVPVGTIILTVTATDADS------GNFALIEYSL 201
Query: 724 QDVTDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISG---AGIYQVTIYIED 779
D AI G I+ LDREK+D Y +T +A+ N G ++ QV I + D
Sbjct: 202 GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLD 261
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDV 839
ND P F + + EN GT + + ATD DEG N Y+L G G E F V
Sbjct: 262 VNDCRPQFSKPQFSTSVYENEPAGTSVIT---MMATDQDEGPNGELTYSLEGPGVEAFHV 318
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQIE 897
D ++G+V EK + L++VA D G L L++ + D NDN+P F +
Sbjct: 319 DMDSGLVTTQRPLQSYEK---FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPP 375
Query: 898 ENSKVRIHRETKL 910
+ + I E L
Sbjct: 376 NGTILHIREEIPL 388
Score = 81.4 bits (192), Expect = 2e-14
Identities = 113/492 (22%), Positives = 204/492 (41%), Gaps = 54/492 (10%)
Query: 443 VNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRT 502
V V + +LD ND P F + S+ N GT + + A D D G NG + Y L+
Sbjct: 253 VQVVIQVLDVNDCRPQFSKPQ-FSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGP 311
Query: 503 SNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
F ++ ++G V+ + +L V A+D P L V I+V
Sbjct: 312 G----VEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVN-- 365
Query: 563 TKGNKPDIPDFMGAPYE--FWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLH--GYEE 616
N+P F+ P + + + ++V ++ D E V Y L G +
Sbjct: 366 --DNRPV---FVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRD 420
Query: 617 GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVV--DVNDERG 674
F ++ SG+I L R ++ +Y VA + T + V D++D
Sbjct: 421 WEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEP 480
Query: 675 VLL---KGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
+ + KG+ + V E+S G +G + + + G F+ A ++ +
Sbjct: 481 LFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGA-VDADEGPNAIVYYFIAAGNEE--KNF 537
Query: 731 AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKG------------VISGAGIYQVTIYIE 778
+ DG + + LDRE+ ++ V A N+ +++ + +V + +E
Sbjct: 538 HLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLE 597
Query: 779 DENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG--EGKEM 836
D ND PP F A Y + ++K+G+E+ + A DAD G N+L Y++ + +
Sbjct: 598 DINDQPPRFTKAEYTAGVATDAKVGSELIQ---VLALDADIGNNSLVFYSILAIHYFRAL 654
Query: 837 FDVDENTGVVKFIG--DSLDREKKIM-------YKLSLVARDTGGLSSEAEL-IIMIGDE 886
+ E+ G V +G D + R + + + +VARD G + A + I ++ D+
Sbjct: 655 ANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDD 714
Query: 887 NDNKPEFNQIEE 898
K N+I +
Sbjct: 715 QRVKIVINEIPD 726
Score = 80.6 bits (190), Expect = 4e-14
Identities = 47/148 (31%), Positives = 78/148 (52%), Gaps = 4/148 (2%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
+ A D D G A + Y L G + F+++ G +++ LD + + +
Sbjct: 184 VTATDADSGNFALIEYSLGDGESK--FAINPTTGDIYVLSSLDREKKDHYILTALAKDNP 241
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
+N + + +V I++LD+ND P+F ++ S+ EN P G SV+ +MATD+D+G
Sbjct: 242 GDVASNRRENS-VQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGP 300
Query: 338 NGEFTYQLDDP-KGAFSIDPRSGWLTVR 364
NGE TY L+ P AF +D SG +T +
Sbjct: 301 NGELTYSLEGPGVEAFHVDMDSGLVTTQ 328
Score = 80.2 bits (189), Expect = 5e-14
Identities = 128/492 (26%), Positives = 206/492 (41%), Gaps = 65/492 (13%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
E++P+GT I+ + A D DSG I Y E K F IN G +
Sbjct: 173 EDVPVGTIILTVTATDADSGNFALIEYSLGDG-------------ESK--FAINPTTGDI 217
Query: 1002 IVARSLPPESEFRLNISALDGGNLND--------NISVRVFVKDVNDHFPVFKKTWYNFN 1053
V SL E + ++AL N D ++ V + V DVND P F K ++ +
Sbjct: 218 YVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTS 277
Query: 1054 VEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETE 1113
V E + + + ATD D G N LTY ++ + F + +G+++ L ++
Sbjct: 278 VYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA-FHVDMDSGLVTTQRPL--QSY 334
Query: 1114 DKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSNHNF 1173
+K+ LTVVA D G DVNDN P F E L ++ +
Sbjct: 335 EKFSLTVVATDGGEPPLWGTTMLLVEVI-DVNDNRPVFVRPPNGTILHIREEIPLRSNVY 393
Query: 1174 ESVMMIPVYKATIEE--NAPIGTTVAKVFAN-DTDF--IGNGNGLILYSLPQRKNQQ--- 1225
E VY +E N + + K N D +F I +GLI + + Q
Sbjct: 394 E------VYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY 447
Query: 1226 -------NLGLPSLSSTAI-LMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELV 1277
+LG P T L V + D+ D + +P S Y+L + ++P +
Sbjct: 448 SLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQL-LTVPEHSPRGTL 506
Query: 1278 SLNLT-----EHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVI 1332
N+T + N + Y+I N+ + F + P +G L ++R DRE + + I
Sbjct: 507 VGNVTGAVDADEGPNAIVYYFIAAGNE---EKNFHLQP-DGCLLVLRDLDREREAIFSFI 562
Query: 1333 VRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTNGNRPLVTAIP 1392
V+A + S P P D++ +T +V+VV ++D+ND P+FT +
Sbjct: 563 VKASSNR-SWTPPRGPSPTL-DLVADLTLQEVRVV--LEDINDQPPRFTKAE--YTAGVA 616
Query: 1393 TTAPFGYQVMQL 1404
T A G +++Q+
Sbjct: 617 TDAKVGSELIQV 628
Score = 77.8 bits (183), Expect = 3e-13
Identities = 54/177 (30%), Positives = 86/177 (48%), Gaps = 9/177 (5%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSL-DSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A+D D G+ + Y L+ L DS G + + +D + H L V
Sbjct: 78 VAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLN-----FTV 132
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+AS +P + A+ V +E++D+NDN P F+ Y ++ E++P G +L V ATD D G
Sbjct: 133 RASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSG 192
Query: 337 ENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGT 393
Y L D + F+I+P +G + V + LDRE + AK+ NP V +
Sbjct: 193 NFALIEYSLGDGESKFAINPTTGDIYVLSS--LDREKKDHYILTALAKD-NPGDVAS 246
Score = 74.5 bits (175), Expect = 3e-12
Identities = 73/237 (30%), Positives = 105/237 (44%), Gaps = 28/237 (11%)
Query: 929 LDVDQLGPLFLIP-------ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LDV+ P F P EN P GT++I + A D D G NG++ Y L
Sbjct: 260 LDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTY-----------SL 308
Query: 982 SADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVKDVN 1039
+E F ++ G V R L +F L + A DGG L + V V DVN
Sbjct: 309 EGPGVEA---FHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVN 365
Query: 1040 DHFPVFKK--TWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPS-DTDLP-FE 1094
D+ PVF + ++ E R + +V ATD D G N + Y F++ + + D F
Sbjct: 366 DNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFI 425
Query: 1095 ISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
I P++G++ LDRE++ Y L +VA D G D++DN P F
Sbjct: 426 IDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLF 482
Score = 61.7 bits (143), Expect = 2e-08
Identities = 59/203 (29%), Positives = 92/203 (45%), Gaps = 23/203 (11%)
Query: 935 GPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVI 994
G + I E IP+ + + ++ A D D GLNG +RY F L +F+I
Sbjct: 377 GTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSF----------LKTAGNRDWEFFII 426
Query: 995 NERHGHVIVARSLPPESE--FRLNISALDGGN---LNDNISVRVFVKDVNDHFPVFKK-- 1047
+ G + A+ L ES+ + L + A D G ++V ++D++D+ P+F +
Sbjct: 427 DPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPP 486
Query: 1048 ----TWYNFNVEEAQYTRRVLGKV-DATDADFGQNANLTYFIQPSDTDLPFEISPLTGVL 1102
+ V E ++G V A DAD G NA + YFI + + F + P G L
Sbjct: 487 KGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCL 545
Query: 1103 SVNGELDRETEDKYILTVVARDN 1125
V +LDRE E + V A N
Sbjct: 546 LVLRDLDREREAIFSFIVKASSN 568
Score = 58.4 bits (135), Expect = 2e-07
Identities = 114/498 (22%), Positives = 199/498 (39%), Gaps = 50/498 (10%)
Query: 83 VTVYIE--DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLI--APIGPSLTIPLTVPRGL 138
+ VY+E D+NDN PIF Y V E P G A G I ++ G
Sbjct: 146 IPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGE 205
Query: 139 TIFK------DI---RAFDRDKPNTPNSDVHYSI--VSGNDDGHFALESSHKPVLLLRKV 187
+ F DI + DR+K + HY + ++ ++ G A V ++ +V
Sbjct: 206 SKFAINPTTGDIYVLSSLDREKKD------HYILTALAKDNPGDVASNRRENSVQVVIQV 259
Query: 188 LDYDAGDKEFQLVIMASGKRIHKEI-LFPEPIHAIDQDLGVGATLRYELISGNDRKLFSL 246
LD + +F ++ ++ + A DQD G L Y L G + F +
Sbjct: 260 LDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHV 318
Query: 247 DSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF 306
D +G + ++ L F L V A+ P + +E++D+NDN P F
Sbjct: 319 DMDSGLVTTQRPLQ-------SYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVF 371
Query: 307 --EVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKG-----AFSIDPRSG 359
+ + I E +P +V +V ATDKD+G NG Y G F IDP SG
Sbjct: 372 VRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISG 431
Query: 360 WLTVRNQTVLDREAHSSLRMKVYAKETNPSVVGTFADSQRIAKWRRQPLETNAPLEKTTY 419
+ + LDRE+ + + + A + V ++A + ++ N PL +
Sbjct: 432 LIQTAQR--LDRESQAVYSLILVASDLGQPVPYETMQPLQVA---LEDIDDNEPL----F 482
Query: 420 VFPDKVGTKTENIEYYDEQLMSFVNVEVT-LLDANDNNPVFVPSNLYEFSMKSNAKVGTV 478
V P K + + + + + VT +DA++ V + + + N +
Sbjct: 483 VRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD 542
Query: 479 IGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEA 538
+ D D + + + ++ +SN + T P +P T+ + L+ + +
Sbjct: 543 GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSP---TLDLVADLTLQEVRVVLEDI 599
Query: 539 SDQPANPSERRYSLAVVT 556
+DQP ++ Y+ V T
Sbjct: 600 NDQPPRFTKAEYTAGVAT 617
Score = 55.2 bits (127), Expect = 2e-06
Identities = 31/90 (34%), Positives = 49/90 (54%), Gaps = 5/90 (5%)
Query: 290 ARVEIELLDLNDNLPEFE---VDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLD 346
A++ + +LD+NDN P+F+ + +Y I+E G +++ V A D D+G NG TY L
Sbjct: 37 AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLL 96
Query: 347 D--PKGAFSIDPRSGWLTVRNQTVLDREAH 374
D P G ++ S + N+TV E H
Sbjct: 97 DLVPPGYVQLEDSSAGKVIANRTVDYEEVH 126
Score = 49.2 bits (112), Expect = 1e-04
Identities = 79/323 (24%), Positives = 135/323 (41%), Gaps = 34/323 (10%)
Query: 81 LSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIA--PIGPS--LTIPLTVP- 135
+ V + + DVND P F + +V E P G + GP+ LT L P
Sbjct: 253 VQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPG 312
Query: 136 -RGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
+ D +P ++V+ D G L + +LL +V+D +
Sbjct: 313 VEAFHVDMDSGLVTTQRPLQSYEKFSLTVVA-TDGGEPPLWGT---TMLLVEVIDVNDNR 368
Query: 195 KEFQLVIMASGKRIHKEILFPE---PIHAIDQDLGVGATLRYELI--SGN-DRKLFSLDS 248
F + I +EI ++A D+D G+ +RY + +GN D + F +D
Sbjct: 369 PVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDP 428
Query: 249 VNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPL--KTAQARVEIELLDLNDNLPEF 306
++G + + LD +++ + L + AS L P+ +T Q +++ L D++DN P F
Sbjct: 429 ISGLIQTAQRLDRESQ-----AVYSLILVASDLGQPVPYETMQP-LQVALEDIDDNEPLF 482
Query: 307 ------EVDFYNISIVENLPNGFSVLQVM-ATDKDQGENGEFTYQL--DDPKGAFSIDPR 357
+ +++ E+ P G V V A D D+G N Y + + + F + P
Sbjct: 483 VRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP- 541
Query: 358 SGWLTVRNQTVLDREAHSSLRMK 380
G L V +REA S +K
Sbjct: 542 DGCLLVLRDLDREREAIFSFIVK 564
Score = 46.8 bits (106), Expect = 6e-04
Identities = 45/165 (27%), Positives = 74/165 (44%), Gaps = 13/165 (7%)
Query: 741 QKPLDREKRDVYRMTVIAEFNKGVISGAGIY----QVTIYIEDENDNPPVFEH---ATYE 793
+ P++RE Y +T+ N + + ++T+ + D NDN P F+ Y
Sbjct: 3 KSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYM 62
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD-S 852
I+E + GT + + A D D+G N L YTL + E++ K I + +
Sbjct: 63 ERILEGATPGTTLIA---VAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRT 119
Query: 853 LDREKKIMYKLSLVARDTGGLSSEAELIIM--IGDENDNKPEFNQ 895
+D E+ ++ A D G AE+ + I D NDN P F+Q
Sbjct: 120 VDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQ 164
Score = 45.2 bits (102), Expect = 0.002
Identities = 35/137 (25%), Positives = 61/137 (44%), Gaps = 15/137 (10%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A+D D G A + Y + +GN+ K F L +G L + ++LD + E +F+++ ++
Sbjct: 513 AVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIF---SFIVKASSN 568
Query: 280 QLNNPLKTAQA-----------RVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQV 328
+ P + V + L D+ND P F Y + + G ++QV
Sbjct: 569 RSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQV 628
Query: 329 MATDKDQGENGEFTYQL 345
+A D D G N Y +
Sbjct: 629 LALDADIGNNSLVFYSI 645
Score = 40.7 bits (91), Expect = 0.039
Identities = 58/199 (29%), Positives = 75/199 (37%), Gaps = 41/199 (20%)
Query: 1028 NISVRVFVKDVNDHFPVFKK---TWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-- 1082
N + V V DVND+ P FK T+Y + E L V A D D G N +TY
Sbjct: 36 NAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTL 95
Query: 1083 --FIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXX 1140
+ P L G + N +D E TV A DNG
Sbjct: 96 LDLVPPGYVQLE---DSSAGKVIANRTVDYEEVHWLNFTVRASDNG-SPPRAAEIPVYLE 151
Query: 1141 XXDVNDNSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVF 1200
D+NDN+P FD+ P Y+ + E+ P+GT + V
Sbjct: 152 IVDINDNNP---IFDQ-----------------------PSYQEAVFEDVPVGTIILTVT 185
Query: 1201 ANDTDFIGNGN-GLILYSL 1218
A D D +GN LI YSL
Sbjct: 186 ATDAD---SGNFALIEYSL 201
Score = 40.7 bits (91), Expect = 0.039
Identities = 40/151 (26%), Positives = 67/151 (44%), Gaps = 12/151 (7%)
Query: 79 AYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPS----LTIPLTV 134
A S+ + D+ VP P V ++++ + +F+ P G LT+P
Sbjct: 445 AVYSLILVASDLGQPVPYETMQPLQVALEDID---DNEPLFVRPPKGSPQYQLLTVPEHS 501
Query: 135 PRGLTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
PRG + A D D+ PN+ V+Y I +GN++ +F L+ LL+ + LD + +
Sbjct: 502 PRGTLVGNVTGAVDADEG--PNAIVYYFIAAGNEEKNFHLQPD--GCLLVLRDLDRER-E 556
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAIDQDL 225
F ++ AS R P P + DL
Sbjct: 557 AIFSFIVKASSNRSWTPPRGPSPTLDLVADL 587
Score = 37.5 bits (83), Expect = 0.37
Identities = 19/51 (37%), Positives = 27/51 (52%), Gaps = 4/51 (7%)
Query: 1441 ATDSDIGINADIRYQILNEQAPR----FAIDPVSGTVRVVAALARDAGRVF 1487
ATD D G+N +RY L R F IDP+SG ++ L R++ V+
Sbjct: 397 ATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY 447
Score = 35.1 bits (77), Expect = 2.0
Identities = 21/54 (38%), Positives = 27/54 (50%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI 1084
VRV ++D+ND P F K Y V L +V A DAD G N+ + Y I
Sbjct: 592 VRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSI 645
>AJ007610-1|CAC22257.1| 950|Homo sapiens protocadherin alpha 9
protein.
Length = 950
Score = 102 bits (245), Expect = 9e-21
Identities = 116/425 (27%), Positives = 173/425 (40%), Gaps = 56/425 (13%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
++G +F +DRE+ V ++ V + ++D NDNPPVF
Sbjct: 80 QNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFPATQKN 139
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
FI E+ + + ++ A+DAD G NAL Y L DV + VK +G
Sbjct: 140 LFIAESRPLDSRFPLEG---ASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLG--- 193
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
LV R EL +++ + KPE L GT
Sbjct: 194 -----------LVLRKLLDREETPELHLLLTATDGGKPE-----------------LTGT 225
Query: 914 AGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
+I V N A D+ +PEN+ IGT +I NA DLD GLNG I Y F+S+
Sbjct: 226 VQL-LITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSD 284
Query: 974 VYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNI 1029
V + ++K F ++ G + V + E ++ + A+D G L +
Sbjct: 285 V----------SPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHC 334
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
++ V V DVND+ P + V+E V+ + D D N +T + P
Sbjct: 335 TLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTP--- 391
Query: 1090 DLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+PF+ +S S ++ LDRE+ Y L V ARD G DVND
Sbjct: 392 HVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGG-SPSLWATARVSVEVADVND 450
Query: 1147 NSPKF 1151
N+P F
Sbjct: 451 NAPAF 455
Score = 92.3 bits (219), Expect = 1e-17
Identities = 116/466 (24%), Positives = 191/466 (40%), Gaps = 39/466 (8%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + +T+LD NDN PVF LY + N +GT++ A D D G NG ++Y
Sbjct: 221 ELTGTVQLLITVLDNNDNAPVF-DRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIY 279
Query: 498 DLQRTSNLTITSPFKINPNTGTVSV-AESPILEGR-HALFVEASDQPANPSERRYSLAVV 555
+ I S F ++P +G ++V E R H + VEA D+ P +L V
Sbjct: 280 SFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVE 339
Query: 556 TIEVTRGTKGNKPDIP-DFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGY 614
++V N P + + P V + +GT + I V D D + +
Sbjct: 340 VVDV----NDNAPQLTIKTLSVP----VKEDAQLGTVIALISVIDL--DADANGQVTCSL 389
Query: 615 EEGVPF-AVEERSGVITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVN 670
VPF V ++V D L R + Y+ A + +L +V V DVN
Sbjct: 390 TPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVN 449
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIA----NQQDV 726
D A S VKEN+ IF + V + + ++ +
Sbjct: 450 DNAPAF---AQSEYTVFVKENNPPGC--HIFTVSARDADAQENALVSYSLVERRLGERSL 504
Query: 727 TDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP 785
+ +++ AE G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 505 SSYVSVHAESGKVYALQPLDHEELELLQFQVSAR-DAGVPPLGSNVTLQVFVLDENDNAP 563
Query: 786 VF---EHATYEGFIMEN--SKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM---F 837
+G + E +G + + ++A DAD G NA Y L E F
Sbjct: 564 ALLTPRMRGTDGAVSEMVLRSVGAGVVVGK-VRAVDADSGYNAWLSYELQPETASASIPF 622
Query: 838 DVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMI 883
V TG + +LD +L ++ +D G + A +++
Sbjct: 623 RVGLYTGEIS-TTRALDETDAPRQRLLVLVKDHGEPALTATATVLV 667
Score = 85.4 bits (202), Expect = 1e-15
Identities = 117/480 (24%), Positives = 187/480 (38%), Gaps = 40/480 (8%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +V+V + D NDN PVF P+ + + + + A D D+G
Sbjct: 105 HLEVIVDRPLQVFHVDVEVKDINDNPPVF-PATQKNLFIAESRPLDSRFPLEGASDADIG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHA----LFVEASDQPANPS 546
+N ++ Y L + P N + + +L+ L + A+D
Sbjct: 164 ENALLTYRLSPNEYFFLDVPTS-NQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPEL 222
Query: 547 ERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QN 604
L + ++ N + P F Y + NV IGT V +D E
Sbjct: 223 TGTVQLLITVLD-------NNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNG 275
Query: 605 DVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQEN-ANLSIVTN 661
D+ Y + F ++ SG ITV+ + + A+ + L+
Sbjct: 276 DIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCT 335
Query: 662 ATVHVVDVNDERGVL-LKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFL 719
V VVDVND L +K P VKE++ G I I ++ + + G V
Sbjct: 336 LLVEVVDVNDNAPQLTIKTLSVP----VKEDAQLGTVIALI---SVIDLDADANGQVTCS 388
Query: 720 IANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIED 779
+ ++ + LDRE Y + V A + G S +V++ + D
Sbjct: 389 LTPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTAR-DGGSPSLWATARVSVEVAD 447
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGK- 834
NDN P F + Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 448 VNDNAPAFAQSEYTVFVKENNPPGCHIFT---VSARDADAQENALVSYSLVERRLGERSL 504
Query: 835 -EMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 505 SSYVSVHAESGKVYAL-QPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAP 563
Score = 64.1 bits (149), Expect = 4e-09
Identities = 62/221 (28%), Positives = 96/221 (43%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y +
Sbjct: 443 VEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYS------LVE 496
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG--NLNDNISVRVF 1034
+L +L Y ++ G V + L E + +SA D G L N++++VF
Sbjct: 497 RRLGERSL--SSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVF 554
Query: 1035 VKDVNDHFP-VFKKTWYNFNVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQP- 1086
V D ND+ P + + ++ R V+GKV A DAD G NA L+Y +QP
Sbjct: 555 VLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPE 614
Query: 1087 -SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+ +PF + TG +S LD + L V+ +D+G
Sbjct: 615 TASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHG 655
Score = 62.1 bits (144), Expect = 1e-08
Identities = 50/154 (32%), Positives = 70/154 (45%), Gaps = 16/154 (10%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGS-----LFLEKELDLDAEHNLQANTFVL 274
A D D+G A L Y L S N+ + + N L L K LD + L L
Sbjct: 157 ASDADIGENALLTYRL-SPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELH-----L 210
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A+ P T ++ I +LD NDN P F+ Y + + EN+ G V+ A+D D
Sbjct: 211 LLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLD 270
Query: 335 QGENGEFTYQLD-----DPKGAFSIDPRSGWLTV 363
+G NG+ Y D K F +DP SG +TV
Sbjct: 271 EGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITV 304
Score = 58.4 bits (135), Expect = 2e-07
Identities = 71/290 (24%), Positives = 114/290 (39%), Gaps = 18/290 (6%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L G +++ + + + + D NDN P+F T Y V + E G + +
Sbjct: 212 LTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDE 271
Query: 127 SLTIPLTVPRGLTIFKDIRA-FDRDKPNTPNSDVHYSIVSGNDDGHFALESSHK--PVL- 182
L + + DI++ F D + + + + + +E+ K P L
Sbjct: 272 GLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLA 331
Query: 183 ----LLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPI---HAIDQDLGVGATLRYEL 235
LL +V+D + D QL I + ++ I ID D + L
Sbjct: 332 GHCTLLVEVVDVN--DNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSL 389
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIE 295
KL S SL L++ LD ++ + + L V A +P A ARV +E
Sbjct: 390 TPHVPFKLVSTYKNYYSLVLDRALDRES-----VSAYELVVTARDGGSPSLWATARVSVE 444
Query: 296 LLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+ D+NDN P F Y + + EN P G + V A D D EN +Y L
Sbjct: 445 VADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL 494
Score = 56.4 bits (130), Expect = 7e-07
Identities = 77/344 (22%), Positives = 143/344 (41%), Gaps = 41/344 (11%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPT--------------GEKAFIFLIAPIGPSL 128
V V ++D+NDN P+F T ++ + E P GE A L + P+
Sbjct: 119 VDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENAL--LTYRLSPNE 176
Query: 129 TIPLTVPRGLTIFKDIRAFDR---DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR 185
L VP K + R D+ TP ++H +++ D G L + V LL
Sbjct: 177 YFFLDVPTSNQQVKPLGLVLRKLLDREETP--ELHL-LLTATDGGKPELTGT---VQLLI 230
Query: 186 KVLDYDAG----DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL---ISG 238
VLD + D+ V + I ++ P +A D D G+ + Y +S
Sbjct: 231 TVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHP---NASDLDEGLNGDIIYSFSSDVSP 287
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
+ + F +D ++G++ + +D + ++ + V+A P + +E++D
Sbjct: 288 DIKSKFHMDPLSGAITVIGHMDFE-----ESRAHKIPVEAVDKGFPPLAGHCTLLVEVVD 342
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRS 358
+NDN P+ + ++ + E+ G + + D D NG+ T L +
Sbjct: 343 VNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYK 402
Query: 359 GWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGTFADSQRIA 401
+ ++ LDRE+ S+ + V A++ +PS+ T S +A
Sbjct: 403 NYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVA 446
Score = 54.0 bits (124), Expect = 4e-06
Identities = 62/219 (28%), Positives = 96/219 (43%), Gaps = 23/219 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ E+ +GT I ++ +DLD+ NGQ+ V P KL + K Y+ +
Sbjct: 359 VKEDAQLGTVIALISVIDLDADANGQVTCSLTPHV---PFKLVST---YKNYYSL----- 407
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
++ R+L ES + L ++A DGG+ L V V V DVND+ P F ++ Y V+
Sbjct: 408 --VLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVK 465
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTDLPFEIS--PLTGVLSVNGELDR 1110
E + V A DAD +NA ++Y + + + L +S +G + LD
Sbjct: 466 ENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDH 525
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
E + V ARD G D NDN+P
Sbjct: 526 EELELLQFQVSARDAG-VPPLGSNVTLQVFVLDENDNAP 563
Score = 52.8 bits (121), Expect = 9e-06
Identities = 55/205 (26%), Positives = 90/205 (43%), Gaps = 13/205 (6%)
Query: 700 IFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAE-----DGTIFTQKPLDREKRDVYRM 754
+ H N S + G++ + ++ DV+ DI G I +D E+ +++
Sbjct: 261 VIHPNASDLDEGLNGDIIYSFSS--DVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKI 318
Query: 755 TVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKA 814
V A +KG AG + + + D NDN P T + E++++GT I + ++I
Sbjct: 319 PVEA-VDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDL 377
Query: 815 TDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLS 874
DAD T K + +V + +LDRE Y+L + ARD G S
Sbjct: 378 -DADANGQVTCSLTPHVPFKLVSTYKNYYSLV--LDRALDRESVSAYELVVTARDGGSPS 434
Query: 875 --SEAELIIMIGDENDNKPEFNQIE 897
+ A + + + D NDN P F Q E
Sbjct: 435 LWATARVSVEVADVNDNAPAFAQSE 459
Score = 48.0 bits (109), Expect = 3e-04
Identities = 56/184 (30%), Positives = 85/184 (46%), Gaps = 17/184 (9%)
Query: 221 IDQDLGVG-ATL---RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQ 275
I QDLG+ A L ++L S L ++ NG LF+ +D + A + L+
Sbjct: 48 IAQDLGLELAELVPRLFQLDSKGRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLE 107
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
V ++ PL+ V++E+ D+NDN P F N+ I E+ P A+D D
Sbjct: 108 VI---VDRPLQVFH--VDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADI 162
Query: 336 GENGEFTYQLDDPKGAFSID-PRSGW----LTVRNQTVLDREAHSSLRMKVYAKE-TNPS 389
GEN TY+L P F +D P S L + + +LDRE L + + A + P
Sbjct: 163 GENALLTYRL-SPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPE 221
Query: 390 VVGT 393
+ GT
Sbjct: 222 LTGT 225
Score = 42.7 bits (96), Expect = 0.010
Identities = 40/156 (25%), Positives = 72/156 (46%), Gaps = 24/156 (15%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++TV D D + PVF Y +++ ENV+ ++ N ++ E
Sbjct: 218 GKPELTGTVQLLITVLDNND-----NAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
N + Y ++ DI+ F +DP +G + ++ D E +++ V A + +
Sbjct: 273 LNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFP---- 328
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
P+A ++V + DVNDN+P+ T
Sbjct: 329 ----PLAG---------HCTLLVEVVDVNDNAPQLT 351
Score = 42.3 bits (95), Expect = 0.013
Identities = 81/347 (23%), Positives = 135/347 (38%), Gaps = 30/347 (8%)
Query: 70 IGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEK----AFIFLIAPIG 125
+ G ++ + ++ V + DVNDN P V V E G + I L A
Sbjct: 323 VDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADAN 382
Query: 126 PSLTIPLT--VPRGL-TIFKDIRAFDRDKPNTPNSDVHYS-IVSGNDDGHFALESSHKPV 181
+T LT VP L + +K+ + D+ S Y +V+ D G +L ++ +
Sbjct: 383 GQVTCSLTPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVS 442
Query: 182 LLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGN-- 239
+ + V D + + + +F + A D D A + Y L+
Sbjct: 443 VEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFT--VSARDADAQENALVSYSLVERRLG 500
Query: 240 DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
+R L S SV+ G ++ + LD + LQ QV A P + +++ +
Sbjct: 501 ERSLSSYVSVHAESGKVYALQPLDHEELELLQ-----FQVSARDAGVPPLGSNVTLQVFV 555
Query: 297 LDLNDNLPEFEVDFYN-----IS--IVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
LD NDN P +S ++ ++ G V +V A D D G N +Y+L
Sbjct: 556 LDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPET 615
Query: 350 GAFSIDPRSGWLT--VRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
+ SI R G T + LD R+ V K+ P++ T
Sbjct: 616 ASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHGEPALTAT 662
Score = 36.3 bits (80), Expect = 0.85
Identities = 20/62 (32%), Positives = 34/62 (54%), Gaps = 5/62 (8%)
Query: 1429 ERLSLNGLT-SPQATDSDIGINADIRYQILNEQAP----RFAIDPVSGTVRVVAALARDA 1483
E +S+ L P A+D D G+N DI Y ++ +P +F +DP+SG + V+ + +
Sbjct: 253 ENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEE 312
Query: 1484 GR 1485
R
Sbjct: 313 SR 314
>AF217743-1|AAK51611.1| 734|Homo sapiens protocadherin-psi2 protein.
Length = 734
Score = 102 bits (245), Expect = 9e-21
Identities = 132/501 (26%), Positives = 209/501 (41%), Gaps = 72/501 (14%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
L I E +GT +A DLD G NG Y + + +D E ++Y
Sbjct: 85 LLKISEGATLGTLFQIDSAQDLDVGKNGVQNYTISPNPHFHLKLRDSD--EGRKY----- 137
Query: 997 RHGHVIVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+++ +SL E SEF L ++A+DGG+ + + V V D++D+ P F+K Y
Sbjct: 138 --PELVLDQSLDREKVSEFSLTLTAVDGGSPPRSGTTLINVVVLDISDNAPEFEKPVYEV 195
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDL--PFEISPLTGVLSVNGELDR 1110
+V E+ ++ K ATD D G N L+Y D+ FEI P++G + + LD
Sbjct: 196 HVPESSPLDSLIIKASATDLDAGINGELSYSFSHVSRDVRKTFEIHPISGEVYLKAPLDF 255
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEWKHPEADELSN 1170
E YI+ + A + G DVNDN P+ A L PE
Sbjct: 256 EIIQSYIINIQAIEGG---SLSGKSSILVRVVDVNDNPPEI-AMTSLTS-PIPE------ 304
Query: 1171 HNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNGLILYSL-------PQRKN 1223
N M++ V+ ++ G TV + ++ F+ Y+L + +N
Sbjct: 305 -NSSPEMVVAVFSIRDQDAGDNGRTVCSI-QDNLPFVLKPTFKNFYALVTEHPLDREVRN 362
Query: 1224 QQN-------LGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVEL 1276
+ N LG P L + + V V+DV D + P+F Y L + EN + + +
Sbjct: 363 EYNITITVTDLGTPRLKTEHNITVLVSDVND-----NAPIFTQTSYTLFVRENNSPALHI 417
Query: 1277 VSLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREVKDTYEVI 1332
S++ T+ N ++ Y +L D + T + I+ NG L+ +RS D E +
Sbjct: 418 GSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSLVSINADNGHLFALRSLDYEALQEFGFR 477
Query: 1333 VRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFTNGNRPLV 1388
V A H ++ +VL V V + D NDNSP NG+ P
Sbjct: 478 VGA--------ADHGSPALSSEVL---------VRVLVLDANDNSPFVLYPLQNGSAPCT 520
Query: 1389 TAIPTTAPFGYQVMQLKGAIG 1409
+P A GY V ++ G
Sbjct: 521 ELVPRAAEPGYLVTKVVAVDG 541
Score = 91.1 bits (216), Expect = 3e-17
Identities = 111/469 (23%), Positives = 191/469 (40%), Gaps = 33/469 (7%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E + F E+ + D ND+ P F+ +++ + A +GT+ A D D+G+NG+
Sbjct: 57 ENPLQFFRAELLVKDINDHTPTFLNNHML-LKISEGATLGTLFQIDSAQDLDVGKNGVQN 115
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGR---HALFVEASDQPANPSERRYSLA 553
Y + + + V + + + +L + A D + P +
Sbjct: 116 YTISPNPHFHLKLRDSDEGRKYPELVLDQSLDREKVSEFSLTLTAVDGGSPPRSGTTLIN 175
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND--AFEQNDVSYDLL 611
VV ++++ + P+F YE V + + + + + D A ++SY
Sbjct: 176 VVVLDIS-------DNAPEFEKPVYEVHVPESSPLDSLIIKASATDLDAGINGELSYSFS 228
Query: 612 H-GYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
H + F + SG + + L Y A+ E +LS ++ V VVDVN
Sbjct: 229 HVSRDVRKTFEIHPISGEVYLKAPLDFEIIQSYIINIQAI-EGGSLSGKSSILVRVVDVN 287
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDI 730
D + A + + + ENS+ + +F NG V + N V
Sbjct: 288 DNPPEI---AMTSLTSPIPENSSPEMVVAVFSIRDQDAGDNGR-TVCSIQDNLPFVLKP- 342
Query: 731 AIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHA 790
+ T+ PLDRE R+ Y +T+ + G + +T+ + D NDN P+F
Sbjct: 343 TFKNFYALVTEHPLDREVRNEYNITITVT-DLGTPRLKTEHNITVLVSDVNDNAPIFTQT 401
Query: 791 TYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDENTG 844
+Y F+ EN+ I + ATD D GTNA Y+L + ++ + G
Sbjct: 402 SYTLFVRENNSPALHI---GSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSLVSINADNG 458
Query: 845 VVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
+ F SLD E + + A D G LSSE + +++ D NDN P
Sbjct: 459 HL-FALRSLDYEALQEFGFRVGAADHGSPALSSEVLVRVLVLDANDNSP 506
Score = 65.3 bits (152), Expect = 2e-09
Identities = 49/170 (28%), Positives = 75/170 (44%), Gaps = 7/170 (4%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQAS 279
A D D+G Y + L DS G + E LD + + + F L + A
Sbjct: 103 AQDLDVGKNGVQNYTISPNPHFHLKLRDSDEGRKYPELVLDQSLDRE-KVSEFSLTLTAV 161
Query: 280 QLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENG 339
+P ++ + + +LD++DN PEFE Y + + E+ P +++ ATD D G NG
Sbjct: 162 DGGSPPRSGTTLINVVVLDISDNAPEFEKPVYEVHVPESSPLDSLIIKASATDLDAGING 221
Query: 340 EFTYQLD----DPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
E +Y D + F I P SG V + LD E S + + A E
Sbjct: 222 ELSYSFSHVSRDVRKTFEIHPISG--EVYLKAPLDFEIIQSYIINIQAIE 269
Score = 64.5 bits (150), Expect = 3e-09
Identities = 59/239 (24%), Positives = 113/239 (47%), Gaps = 19/239 (7%)
Query: 662 ATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLI 720
A + V D+ND L ++ ++ + E GA +G +F + + G V+ + I
Sbjct: 65 AELLVKDINDHTPTFL---NNHMLLKISE---GATLGTLFQIDSAQDLDVGKNGVQNYTI 118
Query: 721 ANQQDVTDDIAIAEDGTIFTQ----KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIY 776
+ + +++G + + + LDREK + +T+ A + G +G + +
Sbjct: 119 SPNPHFHLKLRDSDEGRKYPELVLDQSLDREKVSEFSLTLTA-VDGGSPPRSGTTLINVV 177
Query: 777 IEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM 836
+ D +DN P FE YE + E+S + + I + ATD D G N Y+ +++
Sbjct: 178 VLDISDNAPEFEKPVYEVHVPESSPLDSLIIKAS---ATDLDAGINGELSYSFSHVSRDV 234
Query: 837 ---FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
F++ +G V ++ LD E Y +++ A + G LS ++ +++ + D NDN PE
Sbjct: 235 RKTFEIHPISGEV-YLKAPLDFEIIQSYIINIQAIEGGSLSGKSSILVRVVDVNDNPPE 292
Score = 60.1 bits (139), Expect = 6e-08
Identities = 60/200 (30%), Positives = 85/200 (42%), Gaps = 19/200 (9%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
LF+ N P I ++A D DSG N Q+ Y +PP L + IN
Sbjct: 405 LFVRENNSP-ALHIGSVSATDRDSGTNAQVTYSL-----LPPQD---PHLPLTSLVSINA 455
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+GH+ RSL E+ EF + A D G+ L+ + VRV V D ND+ P N
Sbjct: 456 DNGHLFALRSLDYEALQEFGFRVGAADHGSPALSSEVLVRVLVLDANDNSPFVLYPLQNG 515
Query: 1053 NVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
+ + R ++ KV A D D GQNA L+Y + + F + G
Sbjct: 516 SAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEGRTAR 575
Query: 1107 ELDRETEDKYILTVVARDNG 1126
L K+ L V+ +DNG
Sbjct: 576 LLSERDAAKHRLVVLVKDNG 595
Score = 58.4 bits (135), Expect = 2e-07
Identities = 74/288 (25%), Positives = 119/288 (41%), Gaps = 26/288 (9%)
Query: 77 ISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP--IGPSLTIPLTV 134
+S S+ V + DVNDN P T + E + +F I G + ++
Sbjct: 273 LSGKSSILVRVVDVNDNPPEIAMTSLTSPIPENSSPEMVVAVFSIRDQDAGDNGRTVCSI 332
Query: 135 PRGLTI-----FKDIRAFDRDKPNTPNSDVHYSI-VSGNDDGHFALESSHKPVLLLRKVL 188
L FK+ A + P Y+I ++ D G L++ H +L+ V
Sbjct: 333 QDNLPFVLKPTFKNFYALVTEHPLDREVRNEYNITITVTDLGTPRLKTEHNITVLVSDVN 392
Query: 189 DYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND-----RKL 243
D + + + + L + A D+D G A + Y L+ D L
Sbjct: 393 DNAPIFTQTSYTLFV--RENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSL 450
Query: 244 FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNL 303
S+++ NG LF + LD +A LQ F +V A+ +P +++ V + +LD NDN
Sbjct: 451 VSINADNGHLFALRSLDYEA---LQE--FGFRVGAADHGSPALSSEVLVRVLVLDANDNS 505
Query: 304 PEFEVDFYNISI--VENLPN----GFSVLQVMATDKDQGENGEFTYQL 345
P N S E +P G+ V +V+A D D G+N +YQL
Sbjct: 506 PFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQL 553
Score = 52.8 bits (121), Expect = 9e-06
Identities = 38/165 (23%), Positives = 73/165 (44%), Gaps = 11/165 (6%)
Query: 220 AIDQDLGVGATLRYEL--ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
A D D G+ L Y +S + RK F + ++G ++L+ LD + ++++ +Q
Sbjct: 212 ATDLDAGINGELSYSFSHVSRDVRKTFEIHPISGEVYLKAPLDFEI-----IQSYIINIQ 266
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGE 337
A + + ++ + + ++D+NDN PE + I EN V D+D G+
Sbjct: 267 A--IEGGSLSGKSSILVRVVDVNDNPPEIAMTSLTSPIPENSSPEMVVAVFSIRDQDAGD 324
Query: 338 NGEFTYQLDDPKGAFSIDPR-SGWLTVRNQTVLDREAHSSLRMKV 381
NG + D F + P + + + LDRE + + +
Sbjct: 325 NGRTVCSIQD-NLPFVLKPTFKNFYALVTEHPLDREVRNEYNITI 368
Score = 50.8 bits (116), Expect = 4e-05
Identities = 69/295 (23%), Positives = 113/295 (38%), Gaps = 23/295 (7%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L + G S + V + D++DN P F Y V V E +P +
Sbjct: 158 LTAVDGGSPPRSGTTLINVVVLDISDNAPEFEKPVYEVHVPESSPLDSLIIKASATDLDA 217
Query: 127 SLTIPLTVPRGLTIFKDIRAFDRDKPNTPN----SDVHYSIVSGNDDGHFALES---SHK 179
+ L+ + +D+R P + + + + I+ A+E S K
Sbjct: 218 GINGELSYSFS-HVSRDVRKTFEIHPISGEVYLKAPLDFEIIQSYIINIQAIEGGSLSGK 276
Query: 180 PVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGATLRYEL 235
+L+R V D D ++ + + I E PE + A+ DQD G +
Sbjct: 277 SSILVRVV---DVNDNPPEIAMTSLTSPI-PENSSPEMVVAVFSIRDQDAGDNGRT---V 329
Query: 236 ISGNDRKLFSLDSVNGSLF-LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
S D F L + + L E LD E N + + + + L P + + +
Sbjct: 330 CSIQDNLPFVLKPTFKNFYALVTEHPLDREVR---NEYNITITVTDLGTPRLKTEHNITV 386
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
+ D+NDN P F Y + + EN + V ATD+D G N + TY L P+
Sbjct: 387 LVSDVNDNAPIFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQ 441
Score = 50.4 bits (115), Expect = 5e-05
Identities = 59/256 (23%), Positives = 102/256 (39%), Gaps = 15/256 (5%)
Query: 660 TNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFL 719
T V V+D++D K + HV E+S ++ I + + + G + +
Sbjct: 172 TLINVVVLDISDNAPEFEKPVYE---VHVPESSPLDSL--IIKASATDLDAGINGELSYS 226
Query: 720 IAN-QQDVTDDIAIAE-DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYI 777
++ +DV I G ++ + PLD E Y + + A G +SG + + +
Sbjct: 227 FSHVSRDVRKTFEIHPISGEVYLKAPLDFEIIQSYIINIQA-IEGGSLSGKS--SILVRV 283
Query: 778 EDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMF 837
D NDNPP + I ENS + + +I D D G N + ++ +
Sbjct: 284 VDVNDNPPEIAMTSLTSPIPENSSPEMVVAVFSI---RDQDAGDNGRTVCSIQDNLPFVL 340
Query: 838 DVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
LDRE + Y +++ D G L +E + +++ D NDN P F Q
Sbjct: 341 KPTFKNFYALVTEHPLDREVRNEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPIFTQ 400
Query: 896 IEENSKVRIHRETKLN 911
VR + L+
Sbjct: 401 TSYTLFVRENNSPALH 416
Score = 44.0 bits (99), Expect = 0.004
Identities = 37/124 (29%), Positives = 53/124 (42%), Gaps = 7/124 (5%)
Query: 1033 VFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVD-ATDADFGQNANLTYFIQPS-DTD 1090
+ VKD+NDH P F + E T L ++D A D D G+N Y I P+
Sbjct: 67 LLVKDINDHTPTFLNNHMLLKISEGA-TLGTLFQIDSAQDLDVGKNGVQNYTISPNPHFH 125
Query: 1091 LPFEISP---LTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDN 1147
L S L ++ LDRE ++ LT+ A D G D++DN
Sbjct: 126 LKLRDSDEGRKYPELVLDQSLDREKVSEFSLTLTAVDGG-SPPRSGTTLINVVVLDISDN 184
Query: 1148 SPKF 1151
+P+F
Sbjct: 185 APEF 188
Score = 42.3 bits (95), Expect = 0.013
Identities = 43/151 (28%), Positives = 62/151 (41%), Gaps = 8/151 (5%)
Query: 414 LEKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN- 472
L Y + G + ++ L S V V V +LDANDN+P FV L S
Sbjct: 463 LRSLDYEALQEFGFRVGAADHGSPALSSEVLVRVLVLDANDNSP-FVLYPLQNGSAPCTE 521
Query: 473 -----AKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPI 527
A+ G ++ KV AVD D GQN + Y L + + + + N G + S
Sbjct: 522 LVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHN-GEGRTARLLSER 580
Query: 528 LEGRHALFVEASDQPANPSERRYSLAVVTIE 558
+H L V D P +L V+ +E
Sbjct: 581 DAAKHRLVVLVKDNGEPPRSATATLHVLLVE 611
Score = 39.5 bits (88), Expect = 0.091
Identities = 33/101 (32%), Positives = 51/101 (50%), Gaps = 6/101 (5%)
Query: 246 LDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPE 305
LD NG L L ++LD +A +L +L Q NPL+ +A E+ + D+ND+ P
Sbjct: 23 LDPQNGDLLLNEQLDREALCDL-TEPCILHFQVL-FENPLQFFRA--ELLVKDINDHTPT 78
Query: 306 FEVDFYNISIVENLPNGFSVLQV-MATDKDQGENGEFTYQL 345
F + + I E G ++ Q+ A D D G+NG Y +
Sbjct: 79 FLNNHMLLKISEGATLG-TLFQIDSAQDLDVGKNGVQNYTI 118
>AF152487-1|AAD43748.1| 842|Homo sapiens protocadherin alpha 9 short
form protein protein.
Length = 842
Score = 102 bits (245), Expect = 9e-21
Identities = 116/425 (27%), Positives = 173/425 (40%), Gaps = 56/425 (13%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
++G +F +DRE+ V ++ V + ++D NDNPPVF
Sbjct: 80 QNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFPATQKN 139
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
FI E+ + + ++ A+DAD G NAL Y L DV + VK +G
Sbjct: 140 LFIAESRPLDSRFPLEG---ASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLG--- 193
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
LV R EL +++ + KPE L GT
Sbjct: 194 -----------LVLRKLLDREETPELHLLLTATDGGKPE-----------------LTGT 225
Query: 914 AGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
+I V N A D+ +PEN+ IGT +I NA DLD GLNG I Y F+S+
Sbjct: 226 VQL-LITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSD 284
Query: 974 VYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNI 1029
V + ++K F ++ G + V + E ++ + A+D G L +
Sbjct: 285 V----------SPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHC 334
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
++ V V DVND+ P + V+E V+ + D D N +T + P
Sbjct: 335 TLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTP--- 391
Query: 1090 DLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+PF+ +S S ++ LDRE+ Y L V ARD G DVND
Sbjct: 392 HVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGG-SPSLWATARVSVEVADVND 450
Query: 1147 NSPKF 1151
N+P F
Sbjct: 451 NAPAF 455
Score = 92.3 bits (219), Expect = 1e-17
Identities = 116/466 (24%), Positives = 191/466 (40%), Gaps = 39/466 (8%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + +T+LD NDN PVF LY + N +GT++ A D D G NG ++Y
Sbjct: 221 ELTGTVQLLITVLDNNDNAPVF-DRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIY 279
Query: 498 DLQRTSNLTITSPFKINPNTGTVSV-AESPILEGR-HALFVEASDQPANPSERRYSLAVV 555
+ I S F ++P +G ++V E R H + VEA D+ P +L V
Sbjct: 280 SFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVE 339
Query: 556 TIEVTRGTKGNKPDIP-DFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGY 614
++V N P + + P V + +GT + I V D D + +
Sbjct: 340 VVDV----NDNAPQLTIKTLSVP----VKEDAQLGTVIALISVIDL--DADANGQVTCSL 389
Query: 615 EEGVPF-AVEERSGVITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVN 670
VPF V ++V D L R + Y+ A + +L +V V DVN
Sbjct: 390 TPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVN 449
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIA----NQQDV 726
D A S VKEN+ IF + V + + ++ +
Sbjct: 450 DNAPAF---AQSEYTVFVKENNPPGC--HIFTVSARDADAQENALVSYSLVERRLGERSL 504
Query: 727 TDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP 785
+ +++ AE G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 505 SSYVSVHAESGKVYALQPLDHEELELLQFQVSAR-DAGVPPLGSNVTLQVFVLDENDNAP 563
Query: 786 VF---EHATYEGFIMEN--SKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM---F 837
+G + E +G + + ++A DAD G NA Y L E F
Sbjct: 564 ALLTPRMRGTDGAVSEMVLRSVGAGVVVGK-VRAVDADSGYNAWLSYELQPETASASIPF 622
Query: 838 DVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMI 883
V TG + +LD +L ++ +D G + A +++
Sbjct: 623 RVGLYTGEIS-TTRALDETDAPRQRLLVLVKDHGEPALTATATVLV 667
Score = 85.4 bits (202), Expect = 1e-15
Identities = 117/480 (24%), Positives = 187/480 (38%), Gaps = 40/480 (8%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +V+V + D NDN PVF P+ + + + + A D D+G
Sbjct: 105 HLEVIVDRPLQVFHVDVEVKDINDNPPVF-PATQKNLFIAESRPLDSRFPLEGASDADIG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHA----LFVEASDQPANPS 546
+N ++ Y L + P N + + +L+ L + A+D
Sbjct: 164 ENALLTYRLSPNEYFFLDVPTS-NQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPEL 222
Query: 547 ERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QN 604
L + ++ N + P F Y + NV IGT V +D E
Sbjct: 223 TGTVQLLITVLD-------NNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNG 275
Query: 605 DVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQEN-ANLSIVTN 661
D+ Y + F ++ SG ITV+ + + A+ + L+
Sbjct: 276 DIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCT 335
Query: 662 ATVHVVDVNDERGVL-LKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFL 719
V VVDVND L +K P VKE++ G I I ++ + + G V
Sbjct: 336 LLVEVVDVNDNAPQLTIKTLSVP----VKEDAQLGTVIALI---SVIDLDADANGQVTCS 388
Query: 720 IANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIED 779
+ ++ + LDRE Y + V A + G S +V++ + D
Sbjct: 389 LTPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTAR-DGGSPSLWATARVSVEVAD 447
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGK- 834
NDN P F + Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 448 VNDNAPAFAQSEYTVFVKENNPPGCHIFT---VSARDADAQENALVSYSLVERRLGERSL 504
Query: 835 -EMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 505 SSYVSVHAESGKVYAL-QPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAP 563
Score = 64.1 bits (149), Expect = 4e-09
Identities = 62/221 (28%), Positives = 96/221 (43%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y +
Sbjct: 443 VEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYS------LVE 496
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG--NLNDNISVRVF 1034
+L +L Y ++ G V + L E + +SA D G L N++++VF
Sbjct: 497 RRLGERSL--SSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVF 554
Query: 1035 VKDVNDHFP-VFKKTWYNFNVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQP- 1086
V D ND+ P + + ++ R V+GKV A DAD G NA L+Y +QP
Sbjct: 555 VLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPE 614
Query: 1087 -SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+ +PF + TG +S LD + L V+ +D+G
Sbjct: 615 TASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHG 655
Score = 62.1 bits (144), Expect = 1e-08
Identities = 50/154 (32%), Positives = 70/154 (45%), Gaps = 16/154 (10%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGS-----LFLEKELDLDAEHNLQANTFVL 274
A D D+G A L Y L S N+ + + N L L K LD + L L
Sbjct: 157 ASDADIGENALLTYRL-SPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELH-----L 210
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A+ P T ++ I +LD NDN P F+ Y + + EN+ G V+ A+D D
Sbjct: 211 LLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLD 270
Query: 335 QGENGEFTYQLD-----DPKGAFSIDPRSGWLTV 363
+G NG+ Y D K F +DP SG +TV
Sbjct: 271 EGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITV 304
Score = 58.4 bits (135), Expect = 2e-07
Identities = 71/290 (24%), Positives = 114/290 (39%), Gaps = 18/290 (6%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L G +++ + + + + D NDN P+F T Y V + E G + +
Sbjct: 212 LTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDE 271
Query: 127 SLTIPLTVPRGLTIFKDIRA-FDRDKPNTPNSDVHYSIVSGNDDGHFALESSHK--PVL- 182
L + + DI++ F D + + + + + +E+ K P L
Sbjct: 272 GLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLA 331
Query: 183 ----LLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPI---HAIDQDLGVGATLRYEL 235
LL +V+D + D QL I + ++ I ID D + L
Sbjct: 332 GHCTLLVEVVDVN--DNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSL 389
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIE 295
KL S SL L++ LD ++ + + L V A +P A ARV +E
Sbjct: 390 TPHVPFKLVSTYKNYYSLVLDRALDRES-----VSAYELVVTARDGGSPSLWATARVSVE 444
Query: 296 LLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+ D+NDN P F Y + + EN P G + V A D D EN +Y L
Sbjct: 445 VADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL 494
Score = 56.4 bits (130), Expect = 7e-07
Identities = 77/344 (22%), Positives = 143/344 (41%), Gaps = 41/344 (11%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPT--------------GEKAFIFLIAPIGPSL 128
V V ++D+NDN P+F T ++ + E P GE A L + P+
Sbjct: 119 VDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENAL--LTYRLSPNE 176
Query: 129 TIPLTVPRGLTIFKDIRAFDR---DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR 185
L VP K + R D+ TP ++H +++ D G L + V LL
Sbjct: 177 YFFLDVPTSNQQVKPLGLVLRKLLDREETP--ELHL-LLTATDGGKPELTGT---VQLLI 230
Query: 186 KVLDYDAG----DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL---ISG 238
VLD + D+ V + I ++ P +A D D G+ + Y +S
Sbjct: 231 TVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHP---NASDLDEGLNGDIIYSFSSDVSP 287
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
+ + F +D ++G++ + +D + ++ + V+A P + +E++D
Sbjct: 288 DIKSKFHMDPLSGAITVIGHMDFE-----ESRAHKIPVEAVDKGFPPLAGHCTLLVEVVD 342
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRS 358
+NDN P+ + ++ + E+ G + + D D NG+ T L +
Sbjct: 343 VNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYK 402
Query: 359 GWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGTFADSQRIA 401
+ ++ LDRE+ S+ + V A++ +PS+ T S +A
Sbjct: 403 NYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVA 446
Score = 54.0 bits (124), Expect = 4e-06
Identities = 62/219 (28%), Positives = 96/219 (43%), Gaps = 23/219 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ E+ +GT I ++ +DLD+ NGQ+ V P KL + K Y+ +
Sbjct: 359 VKEDAQLGTVIALISVIDLDADANGQVTCSLTPHV---PFKLVST---YKNYYSL----- 407
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
++ R+L ES + L ++A DGG+ L V V V DVND+ P F ++ Y V+
Sbjct: 408 --VLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVK 465
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTDLPFEIS--PLTGVLSVNGELDR 1110
E + V A DAD +NA ++Y + + + L +S +G + LD
Sbjct: 466 ENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDH 525
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
E + V ARD G D NDN+P
Sbjct: 526 EELELLQFQVSARDAG-VPPLGSNVTLQVFVLDENDNAP 563
Score = 52.8 bits (121), Expect = 9e-06
Identities = 55/205 (26%), Positives = 90/205 (43%), Gaps = 13/205 (6%)
Query: 700 IFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAE-----DGTIFTQKPLDREKRDVYRM 754
+ H N S + G++ + ++ DV+ DI G I +D E+ +++
Sbjct: 261 VIHPNASDLDEGLNGDIIYSFSS--DVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKI 318
Query: 755 TVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKA 814
V A +KG AG + + + D NDN P T + E++++GT I + ++I
Sbjct: 319 PVEA-VDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDL 377
Query: 815 TDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLS 874
DAD T K + +V + +LDRE Y+L + ARD G S
Sbjct: 378 -DADANGQVTCSLTPHVPFKLVSTYKNYYSLV--LDRALDRESVSAYELVVTARDGGSPS 434
Query: 875 --SEAELIIMIGDENDNKPEFNQIE 897
+ A + + + D NDN P F Q E
Sbjct: 435 LWATARVSVEVADVNDNAPAFAQSE 459
Score = 48.0 bits (109), Expect = 3e-04
Identities = 56/184 (30%), Positives = 85/184 (46%), Gaps = 17/184 (9%)
Query: 221 IDQDLGVG-ATL---RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQ 275
I QDLG+ A L ++L S L ++ NG LF+ +D + A + L+
Sbjct: 48 IAQDLGLELAELVPRLFQLDSKGRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLE 107
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
V ++ PL+ V++E+ D+NDN P F N+ I E+ P A+D D
Sbjct: 108 VI---VDRPLQVFH--VDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADI 162
Query: 336 GENGEFTYQLDDPKGAFSID-PRSGW----LTVRNQTVLDREAHSSLRMKVYAKE-TNPS 389
GEN TY+L P F +D P S L + + +LDRE L + + A + P
Sbjct: 163 GENALLTYRL-SPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPE 221
Query: 390 VVGT 393
+ GT
Sbjct: 222 LTGT 225
Score = 42.7 bits (96), Expect = 0.010
Identities = 40/156 (25%), Positives = 72/156 (46%), Gaps = 24/156 (15%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++TV D D + PVF Y +++ ENV+ ++ N ++ E
Sbjct: 218 GKPELTGTVQLLITVLDNND-----NAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
N + Y ++ DI+ F +DP +G + ++ D E +++ V A + +
Sbjct: 273 LNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFP---- 328
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
P+A ++V + DVNDN+P+ T
Sbjct: 329 ----PLAG---------HCTLLVEVVDVNDNAPQLT 351
Score = 42.3 bits (95), Expect = 0.013
Identities = 81/347 (23%), Positives = 135/347 (38%), Gaps = 30/347 (8%)
Query: 70 IGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEK----AFIFLIAPIG 125
+ G ++ + ++ V + DVNDN P V V E G + I L A
Sbjct: 323 VDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADAN 382
Query: 126 PSLTIPLT--VPRGL-TIFKDIRAFDRDKPNTPNSDVHYS-IVSGNDDGHFALESSHKPV 181
+T LT VP L + +K+ + D+ S Y +V+ D G +L ++ +
Sbjct: 383 GQVTCSLTPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVS 442
Query: 182 LLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGN-- 239
+ + V D + + + +F + A D D A + Y L+
Sbjct: 443 VEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFT--VSARDADAQENALVSYSLVERRLG 500
Query: 240 DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
+R L S SV+ G ++ + LD + LQ QV A P + +++ +
Sbjct: 501 ERSLSSYVSVHAESGKVYALQPLDHEELELLQ-----FQVSARDAGVPPLGSNVTLQVFV 555
Query: 297 LDLNDNLPEFEVDFYN-----IS--IVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
LD NDN P +S ++ ++ G V +V A D D G N +Y+L
Sbjct: 556 LDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPET 615
Query: 350 GAFSIDPRSGWLT--VRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
+ SI R G T + LD R+ V K+ P++ T
Sbjct: 616 ASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHGEPALTAT 662
Score = 36.3 bits (80), Expect = 0.85
Identities = 20/62 (32%), Positives = 34/62 (54%), Gaps = 5/62 (8%)
Query: 1429 ERLSLNGLT-SPQATDSDIGINADIRYQILNEQAP----RFAIDPVSGTVRVVAALARDA 1483
E +S+ L P A+D D G+N DI Y ++ +P +F +DP+SG + V+ + +
Sbjct: 253 ENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEE 312
Query: 1484 GR 1485
R
Sbjct: 313 SR 314
>AF152317-1|AAD43711.1| 950|Homo sapiens protocadherin alpha 9
protein.
Length = 950
Score = 102 bits (245), Expect = 9e-21
Identities = 116/425 (27%), Positives = 173/425 (40%), Gaps = 56/425 (13%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
++G +F +DRE+ V ++ V + ++D NDNPPVF
Sbjct: 80 QNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFPATQKN 139
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
FI E+ + + ++ A+DAD G NAL Y L DV + VK +G
Sbjct: 140 LFIAESRPLDSRFPLEG---ASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLG--- 193
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
LV R EL +++ + KPE L GT
Sbjct: 194 -----------LVLRKLLDREETPELHLLLTATDGGKPE-----------------LTGT 225
Query: 914 AGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
+I V N A D+ +PEN+ IGT +I NA DLD GLNG I Y F+S+
Sbjct: 226 VQL-LITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSD 284
Query: 974 VYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNI 1029
V + ++K F ++ G + V + E ++ + A+D G L +
Sbjct: 285 V----------SPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHC 334
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
++ V V DVND+ P + V+E V+ + D D N +T + P
Sbjct: 335 TLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTP--- 391
Query: 1090 DLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+PF+ +S S ++ LDRE+ Y L V ARD G DVND
Sbjct: 392 HVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGG-SPSLWATARVSVEVADVND 450
Query: 1147 NSPKF 1151
N+P F
Sbjct: 451 NAPAF 455
Score = 92.3 bits (219), Expect = 1e-17
Identities = 116/466 (24%), Positives = 191/466 (40%), Gaps = 39/466 (8%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + +T+LD NDN PVF LY + N +GT++ A D D G NG ++Y
Sbjct: 221 ELTGTVQLLITVLDNNDNAPVF-DRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIY 279
Query: 498 DLQRTSNLTITSPFKINPNTGTVSV-AESPILEGR-HALFVEASDQPANPSERRYSLAVV 555
+ I S F ++P +G ++V E R H + VEA D+ P +L V
Sbjct: 280 SFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVE 339
Query: 556 TIEVTRGTKGNKPDIP-DFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGY 614
++V N P + + P V + +GT + I V D D + +
Sbjct: 340 VVDV----NDNAPQLTIKTLSVP----VKEDAQLGTVIALISVIDL--DADANGQVTCSL 389
Query: 615 EEGVPF-AVEERSGVITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVN 670
VPF V ++V D L R + Y+ A + +L +V V DVN
Sbjct: 390 TPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVN 449
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIA----NQQDV 726
D A S VKEN+ IF + V + + ++ +
Sbjct: 450 DNAPAF---AQSEYTVFVKENNPPGC--HIFTVSARDADAQENALVSYSLVERRLGERSL 504
Query: 727 TDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP 785
+ +++ AE G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 505 SSYVSVHAESGKVYALQPLDHEELELLQFQVSAR-DAGVPPLGSNVTLQVFVLDENDNAP 563
Query: 786 VF---EHATYEGFIMEN--SKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM---F 837
+G + E +G + + ++A DAD G NA Y L E F
Sbjct: 564 ALLTPRMRGTDGAVSEMVLRSVGAGVVVGK-VRAVDADSGYNAWLSYELQPETASASIPF 622
Query: 838 DVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMI 883
V TG + +LD +L ++ +D G + A +++
Sbjct: 623 RVGLYTGEIS-TTRALDETDAPRQRLLVLVKDHGEPALTATATVLV 667
Score = 85.4 bits (202), Expect = 1e-15
Identities = 117/480 (24%), Positives = 187/480 (38%), Gaps = 40/480 (8%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +V+V + D NDN PVF P+ + + + + A D D+G
Sbjct: 105 HLEVIVDRPLQVFHVDVEVKDINDNPPVF-PATQKNLFIAESRPLDSRFPLEGASDADIG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHA----LFVEASDQPANPS 546
+N ++ Y L + P N + + +L+ L + A+D
Sbjct: 164 ENALLTYRLSPNEYFFLDVPTS-NQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPEL 222
Query: 547 ERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QN 604
L + ++ N + P F Y + NV IGT V +D E
Sbjct: 223 TGTVQLLITVLD-------NNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNG 275
Query: 605 DVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQEN-ANLSIVTN 661
D+ Y + F ++ SG ITV+ + + A+ + L+
Sbjct: 276 DIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCT 335
Query: 662 ATVHVVDVNDERGVL-LKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFL 719
V VVDVND L +K P VKE++ G I I ++ + + G V
Sbjct: 336 LLVEVVDVNDNAPQLTIKTLSVP----VKEDAQLGTVIALI---SVIDLDADANGQVTCS 388
Query: 720 IANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIED 779
+ ++ + LDRE Y + V A + G S +V++ + D
Sbjct: 389 LTPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTAR-DGGSPSLWATARVSVEVAD 447
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGK- 834
NDN P F + Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 448 VNDNAPAFAQSEYTVFVKENNPPGCHIFT---VSARDADAQENALVSYSLVERRLGERSL 504
Query: 835 -EMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 505 SSYVSVHAESGKVYAL-QPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAP 563
Score = 64.1 bits (149), Expect = 4e-09
Identities = 62/221 (28%), Positives = 96/221 (43%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y +
Sbjct: 443 VEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYS------LVE 496
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG--NLNDNISVRVF 1034
+L +L Y ++ G V + L E + +SA D G L N++++VF
Sbjct: 497 RRLGERSL--SSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVF 554
Query: 1035 VKDVNDHFP-VFKKTWYNFNVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQP- 1086
V D ND+ P + + ++ R V+GKV A DAD G NA L+Y +QP
Sbjct: 555 VLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPE 614
Query: 1087 -SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+ +PF + TG +S LD + L V+ +D+G
Sbjct: 615 TASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHG 655
Score = 62.1 bits (144), Expect = 1e-08
Identities = 50/154 (32%), Positives = 70/154 (45%), Gaps = 16/154 (10%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGS-----LFLEKELDLDAEHNLQANTFVL 274
A D D+G A L Y L S N+ + + N L L K LD + L L
Sbjct: 157 ASDADIGENALLTYRL-SPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELH-----L 210
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A+ P T ++ I +LD NDN P F+ Y + + EN+ G V+ A+D D
Sbjct: 211 LLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLD 270
Query: 335 QGENGEFTYQLD-----DPKGAFSIDPRSGWLTV 363
+G NG+ Y D K F +DP SG +TV
Sbjct: 271 EGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITV 304
Score = 58.4 bits (135), Expect = 2e-07
Identities = 71/290 (24%), Positives = 114/290 (39%), Gaps = 18/290 (6%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L G +++ + + + + D NDN P+F T Y V + E G + +
Sbjct: 212 LTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDE 271
Query: 127 SLTIPLTVPRGLTIFKDIRA-FDRDKPNTPNSDVHYSIVSGNDDGHFALESSHK--PVL- 182
L + + DI++ F D + + + + + +E+ K P L
Sbjct: 272 GLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLA 331
Query: 183 ----LLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPI---HAIDQDLGVGATLRYEL 235
LL +V+D + D QL I + ++ I ID D + L
Sbjct: 332 GHCTLLVEVVDVN--DNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSL 389
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIE 295
KL S SL L++ LD ++ + + L V A +P A ARV +E
Sbjct: 390 TPHVPFKLVSTYKNYYSLVLDRALDRES-----VSAYELVVTARDGGSPSLWATARVSVE 444
Query: 296 LLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+ D+NDN P F Y + + EN P G + V A D D EN +Y L
Sbjct: 445 VADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL 494
Score = 56.4 bits (130), Expect = 7e-07
Identities = 77/344 (22%), Positives = 143/344 (41%), Gaps = 41/344 (11%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPT--------------GEKAFIFLIAPIGPSL 128
V V ++D+NDN P+F T ++ + E P GE A L + P+
Sbjct: 119 VDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENAL--LTYRLSPNE 176
Query: 129 TIPLTVPRGLTIFKDIRAFDR---DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR 185
L VP K + R D+ TP ++H +++ D G L + V LL
Sbjct: 177 YFFLDVPTSNQQVKPLGLVLRKLLDREETP--ELHL-LLTATDGGKPELTGT---VQLLI 230
Query: 186 KVLDYDAG----DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL---ISG 238
VLD + D+ V + I ++ P +A D D G+ + Y +S
Sbjct: 231 TVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHP---NASDLDEGLNGDIIYSFSSDVSP 287
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
+ + F +D ++G++ + +D + ++ + V+A P + +E++D
Sbjct: 288 DIKSKFHMDPLSGAITVIGHMDFE-----ESRAHKIPVEAVDKGFPPLAGHCTLLVEVVD 342
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRS 358
+NDN P+ + ++ + E+ G + + D D NG+ T L +
Sbjct: 343 VNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYK 402
Query: 359 GWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGTFADSQRIA 401
+ ++ LDRE+ S+ + V A++ +PS+ T S +A
Sbjct: 403 NYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVA 446
Score = 54.0 bits (124), Expect = 4e-06
Identities = 62/219 (28%), Positives = 96/219 (43%), Gaps = 23/219 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ E+ +GT I ++ +DLD+ NGQ+ V P KL + K Y+ +
Sbjct: 359 VKEDAQLGTVIALISVIDLDADANGQVTCSLTPHV---PFKLVST---YKNYYSL----- 407
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
++ R+L ES + L ++A DGG+ L V V V DVND+ P F ++ Y V+
Sbjct: 408 --VLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVK 465
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTDLPFEIS--PLTGVLSVNGELDR 1110
E + V A DAD +NA ++Y + + + L +S +G + LD
Sbjct: 466 ENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDH 525
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
E + V ARD G D NDN+P
Sbjct: 526 EELELLQFQVSARDAG-VPPLGSNVTLQVFVLDENDNAP 563
Score = 52.8 bits (121), Expect = 9e-06
Identities = 55/205 (26%), Positives = 90/205 (43%), Gaps = 13/205 (6%)
Query: 700 IFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAE-----DGTIFTQKPLDREKRDVYRM 754
+ H N S + G++ + ++ DV+ DI G I +D E+ +++
Sbjct: 261 VIHPNASDLDEGLNGDIIYSFSS--DVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKI 318
Query: 755 TVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKA 814
V A +KG AG + + + D NDN P T + E++++GT I + ++I
Sbjct: 319 PVEA-VDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDL 377
Query: 815 TDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLS 874
DAD T K + +V + +LDRE Y+L + ARD G S
Sbjct: 378 -DADANGQVTCSLTPHVPFKLVSTYKNYYSLV--LDRALDRESVSAYELVVTARDGGSPS 434
Query: 875 --SEAELIIMIGDENDNKPEFNQIE 897
+ A + + + D NDN P F Q E
Sbjct: 435 LWATARVSVEVADVNDNAPAFAQSE 459
Score = 48.0 bits (109), Expect = 3e-04
Identities = 56/184 (30%), Positives = 85/184 (46%), Gaps = 17/184 (9%)
Query: 221 IDQDLGVG-ATL---RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQ 275
I QDLG+ A L ++L S L ++ NG LF+ +D + A + L+
Sbjct: 48 IAQDLGLELAELVPRLFQLDSKGRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLE 107
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
V ++ PL+ V++E+ D+NDN P F N+ I E+ P A+D D
Sbjct: 108 VI---VDRPLQVFH--VDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADI 162
Query: 336 GENGEFTYQLDDPKGAFSID-PRSGW----LTVRNQTVLDREAHSSLRMKVYAKE-TNPS 389
GEN TY+L P F +D P S L + + +LDRE L + + A + P
Sbjct: 163 GENALLTYRL-SPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPE 221
Query: 390 VVGT 393
+ GT
Sbjct: 222 LTGT 225
Score = 42.7 bits (96), Expect = 0.010
Identities = 40/156 (25%), Positives = 72/156 (46%), Gaps = 24/156 (15%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++TV D D + PVF Y +++ ENV+ ++ N ++ E
Sbjct: 218 GKPELTGTVQLLITVLDNND-----NAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
N + Y ++ DI+ F +DP +G + ++ D E +++ V A + +
Sbjct: 273 LNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFP---- 328
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
P+A ++V + DVNDN+P+ T
Sbjct: 329 ----PLAG---------HCTLLVEVVDVNDNAPQLT 351
Score = 42.3 bits (95), Expect = 0.013
Identities = 81/347 (23%), Positives = 135/347 (38%), Gaps = 30/347 (8%)
Query: 70 IGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEK----AFIFLIAPIG 125
+ G ++ + ++ V + DVNDN P V V E G + I L A
Sbjct: 323 VDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADAN 382
Query: 126 PSLTIPLT--VPRGL-TIFKDIRAFDRDKPNTPNSDVHYS-IVSGNDDGHFALESSHKPV 181
+T LT VP L + +K+ + D+ S Y +V+ D G +L ++ +
Sbjct: 383 GQVTCSLTPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVS 442
Query: 182 LLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGN-- 239
+ + V D + + + +F + A D D A + Y L+
Sbjct: 443 VEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFT--VSARDADAQENALVSYSLVERRLG 500
Query: 240 DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
+R L S SV+ G ++ + LD + LQ QV A P + +++ +
Sbjct: 501 ERSLSSYVSVHAESGKVYALQPLDHEELELLQ-----FQVSARDAGVPPLGSNVTLQVFV 555
Query: 297 LDLNDNLPEFEVDFYN-----IS--IVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
LD NDN P +S ++ ++ G V +V A D D G N +Y+L
Sbjct: 556 LDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPET 615
Query: 350 GAFSIDPRSGWLT--VRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
+ SI R G T + LD R+ V K+ P++ T
Sbjct: 616 ASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHGEPALTAT 662
Score = 36.3 bits (80), Expect = 0.85
Identities = 20/62 (32%), Positives = 34/62 (54%), Gaps = 5/62 (8%)
Query: 1429 ERLSLNGLT-SPQATDSDIGINADIRYQILNEQAP----RFAIDPVSGTVRVVAALARDA 1483
E +S+ L P A+D D G+N DI Y ++ +P +F +DP+SG + V+ + +
Sbjct: 253 ENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEE 312
Query: 1484 GR 1485
R
Sbjct: 313 SR 314
>AC005609-5|AAC34313.1| 842|Homo sapiens KIAA0345-like 5 protein.
Length = 842
Score = 102 bits (245), Expect = 9e-21
Identities = 116/425 (27%), Positives = 173/425 (40%), Gaps = 56/425 (13%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
++G +F +DRE+ V ++ V + ++D NDNPPVF
Sbjct: 80 QNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFPATQKN 139
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
FI E+ + + ++ A+DAD G NAL Y L DV + VK +G
Sbjct: 140 LFIAESRPLDSRFPLEG---ASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLG--- 193
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
LV R EL +++ + KPE L GT
Sbjct: 194 -----------LVLRKLLDREETPELHLLLTATDGGKPE-----------------LTGT 225
Query: 914 AGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
+I V N A D+ +PEN+ IGT +I NA DLD GLNG I Y F+S+
Sbjct: 226 VQL-LITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSD 284
Query: 974 VYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNI 1029
V + ++K F ++ G + V + E ++ + A+D G L +
Sbjct: 285 V----------SPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHC 334
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
++ V V DVND+ P + V+E V+ + D D N +T + P
Sbjct: 335 TLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTP--- 391
Query: 1090 DLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+PF+ +S S ++ LDRE+ Y L V ARD G DVND
Sbjct: 392 HVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGG-SPSLWATARVSVEVADVND 450
Query: 1147 NSPKF 1151
N+P F
Sbjct: 451 NAPAF 455
Score = 92.3 bits (219), Expect = 1e-17
Identities = 116/466 (24%), Positives = 191/466 (40%), Gaps = 39/466 (8%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + +T+LD NDN PVF LY + N +GT++ A D D G NG ++Y
Sbjct: 221 ELTGTVQLLITVLDNNDNAPVF-DRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIY 279
Query: 498 DLQRTSNLTITSPFKINPNTGTVSV-AESPILEGR-HALFVEASDQPANPSERRYSLAVV 555
+ I S F ++P +G ++V E R H + VEA D+ P +L V
Sbjct: 280 SFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVE 339
Query: 556 TIEVTRGTKGNKPDIP-DFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGY 614
++V N P + + P V + +GT + I V D D + +
Sbjct: 340 VVDV----NDNAPQLTIKTLSVP----VKEDAQLGTVIALISVIDL--DADANGQVTCSL 389
Query: 615 EEGVPF-AVEERSGVITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVN 670
VPF V ++V D L R + Y+ A + +L +V V DVN
Sbjct: 390 TPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVN 449
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIA----NQQDV 726
D A S VKEN+ IF + V + + ++ +
Sbjct: 450 DNAPAF---AQSEYTVFVKENNPPGC--HIFTVSARDADAQENALVSYSLVERRLGERSL 504
Query: 727 TDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP 785
+ +++ AE G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 505 SSYVSVHAESGKVYALQPLDHEELELLQFQVSAR-DAGVPPLGSNVTLQVFVLDENDNAP 563
Query: 786 VF---EHATYEGFIMEN--SKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM---F 837
+G + E +G + + ++A DAD G NA Y L E F
Sbjct: 564 ALLTPRMRGTDGAVSEMVLRSVGAGVVVGK-VRAVDADSGYNAWLSYELQPETASASIPF 622
Query: 838 DVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMI 883
V TG + +LD +L ++ +D G + A +++
Sbjct: 623 RVGLYTGEIS-TTRALDETDAPRQRLLVLVKDHGEPALTATATVLV 667
Score = 85.4 bits (202), Expect = 1e-15
Identities = 117/480 (24%), Positives = 187/480 (38%), Gaps = 40/480 (8%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +V+V + D NDN PVF P+ + + + + A D D+G
Sbjct: 105 HLEVIVDRPLQVFHVDVEVKDINDNPPVF-PATQKNLFIAESRPLDSRFPLEGASDADIG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHA----LFVEASDQPANPS 546
+N ++ Y L + P N + + +L+ L + A+D
Sbjct: 164 ENALLTYRLSPNEYFFLDVPTS-NQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPEL 222
Query: 547 ERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QN 604
L + ++ N + P F Y + NV IGT V +D E
Sbjct: 223 TGTVQLLITVLD-------NNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNG 275
Query: 605 DVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQEN-ANLSIVTN 661
D+ Y + F ++ SG ITV+ + + A+ + L+
Sbjct: 276 DIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCT 335
Query: 662 ATVHVVDVNDERGVL-LKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFL 719
V VVDVND L +K P VKE++ G I I ++ + + G V
Sbjct: 336 LLVEVVDVNDNAPQLTIKTLSVP----VKEDAQLGTVIALI---SVIDLDADANGQVTCS 388
Query: 720 IANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIED 779
+ ++ + LDRE Y + V A + G S +V++ + D
Sbjct: 389 LTPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTAR-DGGSPSLWATARVSVEVAD 447
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGK- 834
NDN P F + Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 448 VNDNAPAFAQSEYTVFVKENNPPGCHIFT---VSARDADAQENALVSYSLVERRLGERSL 504
Query: 835 -EMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 505 SSYVSVHAESGKVYAL-QPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAP 563
Score = 64.1 bits (149), Expect = 4e-09
Identities = 62/221 (28%), Positives = 96/221 (43%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y +
Sbjct: 443 VEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYS------LVE 496
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG--NLNDNISVRVF 1034
+L +L Y ++ G V + L E + +SA D G L N++++VF
Sbjct: 497 RRLGERSL--SSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVF 554
Query: 1035 VKDVNDHFP-VFKKTWYNFNVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQP- 1086
V D ND+ P + + ++ R V+GKV A DAD G NA L+Y +QP
Sbjct: 555 VLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPE 614
Query: 1087 -SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+ +PF + TG +S LD + L V+ +D+G
Sbjct: 615 TASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHG 655
Score = 62.1 bits (144), Expect = 1e-08
Identities = 50/154 (32%), Positives = 70/154 (45%), Gaps = 16/154 (10%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGS-----LFLEKELDLDAEHNLQANTFVL 274
A D D+G A L Y L S N+ + + N L L K LD + L L
Sbjct: 157 ASDADIGENALLTYRL-SPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELH-----L 210
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A+ P T ++ I +LD NDN P F+ Y + + EN+ G V+ A+D D
Sbjct: 211 LLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLD 270
Query: 335 QGENGEFTYQLD-----DPKGAFSIDPRSGWLTV 363
+G NG+ Y D K F +DP SG +TV
Sbjct: 271 EGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITV 304
Score = 58.4 bits (135), Expect = 2e-07
Identities = 71/290 (24%), Positives = 114/290 (39%), Gaps = 18/290 (6%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L G +++ + + + + D NDN P+F T Y V + E G + +
Sbjct: 212 LTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDE 271
Query: 127 SLTIPLTVPRGLTIFKDIRA-FDRDKPNTPNSDVHYSIVSGNDDGHFALESSHK--PVL- 182
L + + DI++ F D + + + + + +E+ K P L
Sbjct: 272 GLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLA 331
Query: 183 ----LLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPI---HAIDQDLGVGATLRYEL 235
LL +V+D + D QL I + ++ I ID D + L
Sbjct: 332 GHCTLLVEVVDVN--DNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSL 389
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIE 295
KL S SL L++ LD ++ + + L V A +P A ARV +E
Sbjct: 390 TPHVPFKLVSTYKNYYSLVLDRALDRES-----VSAYELVVTARDGGSPSLWATARVSVE 444
Query: 296 LLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+ D+NDN P F Y + + EN P G + V A D D EN +Y L
Sbjct: 445 VADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL 494
Score = 56.4 bits (130), Expect = 7e-07
Identities = 77/344 (22%), Positives = 143/344 (41%), Gaps = 41/344 (11%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPT--------------GEKAFIFLIAPIGPSL 128
V V ++D+NDN P+F T ++ + E P GE A L + P+
Sbjct: 119 VDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENAL--LTYRLSPNE 176
Query: 129 TIPLTVPRGLTIFKDIRAFDR---DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR 185
L VP K + R D+ TP ++H +++ D G L + V LL
Sbjct: 177 YFFLDVPTSNQQVKPLGLVLRKLLDREETP--ELHL-LLTATDGGKPELTGT---VQLLI 230
Query: 186 KVLDYDAG----DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL---ISG 238
VLD + D+ V + I ++ P +A D D G+ + Y +S
Sbjct: 231 TVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHP---NASDLDEGLNGDIIYSFSSDVSP 287
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
+ + F +D ++G++ + +D + ++ + V+A P + +E++D
Sbjct: 288 DIKSKFHMDPLSGAITVIGHMDFE-----ESRAHKIPVEAVDKGFPPLAGHCTLLVEVVD 342
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRS 358
+NDN P+ + ++ + E+ G + + D D NG+ T L +
Sbjct: 343 VNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYK 402
Query: 359 GWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGTFADSQRIA 401
+ ++ LDRE+ S+ + V A++ +PS+ T S +A
Sbjct: 403 NYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVA 446
Score = 54.0 bits (124), Expect = 4e-06
Identities = 62/219 (28%), Positives = 96/219 (43%), Gaps = 23/219 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ E+ +GT I ++ +DLD+ NGQ+ V P KL + K Y+ +
Sbjct: 359 VKEDAQLGTVIALISVIDLDADANGQVTCSLTPHV---PFKLVST---YKNYYSL----- 407
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
++ R+L ES + L ++A DGG+ L V V V DVND+ P F ++ Y V+
Sbjct: 408 --VLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVK 465
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTDLPFEIS--PLTGVLSVNGELDR 1110
E + V A DAD +NA ++Y + + + L +S +G + LD
Sbjct: 466 ENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDH 525
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
E + V ARD G D NDN+P
Sbjct: 526 EELELLQFQVSARDAG-VPPLGSNVTLQVFVLDENDNAP 563
Score = 52.8 bits (121), Expect = 9e-06
Identities = 55/205 (26%), Positives = 90/205 (43%), Gaps = 13/205 (6%)
Query: 700 IFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAE-----DGTIFTQKPLDREKRDVYRM 754
+ H N S + G++ + ++ DV+ DI G I +D E+ +++
Sbjct: 261 VIHPNASDLDEGLNGDIIYSFSS--DVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKI 318
Query: 755 TVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKA 814
V A +KG AG + + + D NDN P T + E++++GT I + ++I
Sbjct: 319 PVEA-VDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDL 377
Query: 815 TDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLS 874
DAD T K + +V + +LDRE Y+L + ARD G S
Sbjct: 378 -DADANGQVTCSLTPHVPFKLVSTYKNYYSLV--LDRALDRESVSAYELVVTARDGGSPS 434
Query: 875 --SEAELIIMIGDENDNKPEFNQIE 897
+ A + + + D NDN P F Q E
Sbjct: 435 LWATARVSVEVADVNDNAPAFAQSE 459
Score = 48.0 bits (109), Expect = 3e-04
Identities = 56/184 (30%), Positives = 85/184 (46%), Gaps = 17/184 (9%)
Query: 221 IDQDLGVG-ATL---RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQ 275
I QDLG+ A L ++L S L ++ NG LF+ +D + A + L+
Sbjct: 48 IAQDLGLELAELVPRLFQLDSKGRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLE 107
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
V ++ PL+ V++E+ D+NDN P F N+ I E+ P A+D D
Sbjct: 108 VI---VDRPLQVFH--VDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADI 162
Query: 336 GENGEFTYQLDDPKGAFSID-PRSGW----LTVRNQTVLDREAHSSLRMKVYAKE-TNPS 389
GEN TY+L P F +D P S L + + +LDRE L + + A + P
Sbjct: 163 GENALLTYRL-SPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPE 221
Query: 390 VVGT 393
+ GT
Sbjct: 222 LTGT 225
Score = 42.7 bits (96), Expect = 0.010
Identities = 40/156 (25%), Positives = 72/156 (46%), Gaps = 24/156 (15%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++TV D D + PVF Y +++ ENV+ ++ N ++ E
Sbjct: 218 GKPELTGTVQLLITVLDNND-----NAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
N + Y ++ DI+ F +DP +G + ++ D E +++ V A + +
Sbjct: 273 LNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFP---- 328
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
P+A ++V + DVNDN+P+ T
Sbjct: 329 ----PLAG---------HCTLLVEVVDVNDNAPQLT 351
Score = 42.3 bits (95), Expect = 0.013
Identities = 81/347 (23%), Positives = 135/347 (38%), Gaps = 30/347 (8%)
Query: 70 IGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEK----AFIFLIAPIG 125
+ G ++ + ++ V + DVNDN P V V E G + I L A
Sbjct: 323 VDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADAN 382
Query: 126 PSLTIPLT--VPRGL-TIFKDIRAFDRDKPNTPNSDVHYS-IVSGNDDGHFALESSHKPV 181
+T LT VP L + +K+ + D+ S Y +V+ D G +L ++ +
Sbjct: 383 GQVTCSLTPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVS 442
Query: 182 LLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGN-- 239
+ + V D + + + +F + A D D A + Y L+
Sbjct: 443 VEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFT--VSARDADAQENALVSYSLVERRLG 500
Query: 240 DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
+R L S SV+ G ++ + LD + LQ QV A P + +++ +
Sbjct: 501 ERSLSSYVSVHAESGKVYALQPLDHEELELLQ-----FQVSARDAGVPPLGSNVTLQVFV 555
Query: 297 LDLNDNLPEFEVDFYN-----IS--IVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
LD NDN P +S ++ ++ G V +V A D D G N +Y+L
Sbjct: 556 LDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPET 615
Query: 350 GAFSIDPRSGWLT--VRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
+ SI R G T + LD R+ V K+ P++ T
Sbjct: 616 ASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHGEPALTAT 662
Score = 36.3 bits (80), Expect = 0.85
Identities = 20/62 (32%), Positives = 34/62 (54%), Gaps = 5/62 (8%)
Query: 1429 ERLSLNGLT-SPQATDSDIGINADIRYQILNEQAP----RFAIDPVSGTVRVVAALARDA 1483
E +S+ L P A+D D G+N DI Y ++ +P +F +DP+SG + V+ + +
Sbjct: 253 ENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEE 312
Query: 1484 GR 1485
R
Sbjct: 313 SR 314
>AB002343-1|BAA20803.2| 845|Homo sapiens KIAA0345 protein.
Length = 845
Score = 102 bits (245), Expect = 9e-21
Identities = 116/425 (27%), Positives = 173/425 (40%), Gaps = 56/425 (13%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
++G +F +DRE+ V ++ V + ++D NDNPPVF
Sbjct: 83 QNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFPATQKN 142
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
FI E+ + + ++ A+DAD G NAL Y L DV + VK +G
Sbjct: 143 LFIAESRPLDSRFPLEG---ASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKPLG--- 196
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
LV R EL +++ + KPE L GT
Sbjct: 197 -----------LVLRKLLDREETPELHLLLTATDGGKPE-----------------LTGT 228
Query: 914 AGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
+I V N A D+ +PEN+ IGT +I NA DLD GLNG I Y F+S+
Sbjct: 229 VQL-LITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSD 287
Query: 974 VYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNI 1029
V + ++K F ++ G + V + E ++ + A+D G L +
Sbjct: 288 V----------SPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHC 337
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
++ V V DVND+ P + V+E V+ + D D N +T + P
Sbjct: 338 TLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTP--- 394
Query: 1090 DLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+PF+ +S S ++ LDRE+ Y L V ARD G DVND
Sbjct: 395 HVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGG-SPSLWATARVSVEVADVND 453
Query: 1147 NSPKF 1151
N+P F
Sbjct: 454 NAPAF 458
Score = 92.3 bits (219), Expect = 1e-17
Identities = 116/466 (24%), Positives = 191/466 (40%), Gaps = 39/466 (8%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + +T+LD NDN PVF LY + N +GT++ A D D G NG ++Y
Sbjct: 224 ELTGTVQLLITVLDNNDNAPVF-DRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIY 282
Query: 498 DLQRTSNLTITSPFKINPNTGTVSV-AESPILEGR-HALFVEASDQPANPSERRYSLAVV 555
+ I S F ++P +G ++V E R H + VEA D+ P +L V
Sbjct: 283 SFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVE 342
Query: 556 TIEVTRGTKGNKPDIP-DFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGY 614
++V N P + + P V + +GT + I V D D + +
Sbjct: 343 VVDV----NDNAPQLTIKTLSVP----VKEDAQLGTVIALISVIDL--DADANGQVTCSL 392
Query: 615 EEGVPF-AVEERSGVITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVN 670
VPF V ++V D L R + Y+ A + +L +V V DVN
Sbjct: 393 TPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVN 452
Query: 671 DERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIA----NQQDV 726
D A S VKEN+ IF + V + + ++ +
Sbjct: 453 DNAPAF---AQSEYTVFVKENNPPGC--HIFTVSARDADAQENALVSYSLVERRLGERSL 507
Query: 727 TDDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPP 785
+ +++ AE G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 508 SSYVSVHAESGKVYALQPLDHEELELLQFQVSAR-DAGVPPLGSNVTLQVFVLDENDNAP 566
Query: 786 VF---EHATYEGFIMEN--SKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM---F 837
+G + E +G + + ++A DAD G NA Y L E F
Sbjct: 567 ALLTPRMRGTDGAVSEMVLRSVGAGVVVGK-VRAVDADSGYNAWLSYELQPETASASIPF 625
Query: 838 DVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMI 883
V TG + +LD +L ++ +D G + A +++
Sbjct: 626 RVGLYTGEIS-TTRALDETDAPRQRLLVLVKDHGEPALTATATVLV 670
Score = 85.4 bits (202), Expect = 1e-15
Identities = 117/480 (24%), Positives = 187/480 (38%), Gaps = 40/480 (8%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +V+V + D NDN PVF P+ + + + + A D D+G
Sbjct: 108 HLEVIVDRPLQVFHVDVEVKDINDNPPVF-PATQKNLFIAESRPLDSRFPLEGASDADIG 166
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHA----LFVEASDQPANPS 546
+N ++ Y L + P N + + +L+ L + A+D
Sbjct: 167 ENALLTYRLSPNEYFFLDVPTS-NQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPEL 225
Query: 547 ERRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QN 604
L + ++ N + P F Y + NV IGT V +D E
Sbjct: 226 TGTVQLLITVLD-------NNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNG 278
Query: 605 DVSYDLLHGYEEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQEN-ANLSIVTN 661
D+ Y + F ++ SG ITV+ + + A+ + L+
Sbjct: 279 DIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCT 338
Query: 662 ATVHVVDVNDERGVL-LKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFL 719
V VVDVND L +K P VKE++ G I I ++ + + G V
Sbjct: 339 LLVEVVDVNDNAPQLTIKTLSVP----VKEDAQLGTVIALI---SVIDLDADANGQVTCS 391
Query: 720 IANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIED 779
+ ++ + LDRE Y + V A + G S +V++ + D
Sbjct: 392 LTPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTAR-DGGSPSLWATARVSVEVAD 450
Query: 780 ENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEGK- 834
NDN P F + Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 451 VNDNAPAFAQSEYTVFVKENNPPGCHIFT---VSARDADAQENALVSYSLVERRLGERSL 507
Query: 835 -EMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 508 SSYVSVHAESGKVYAL-QPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAP 566
Score = 64.1 bits (149), Expect = 4e-09
Identities = 62/221 (28%), Positives = 96/221 (43%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y +
Sbjct: 446 VEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYS------LVE 499
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGG--NLNDNISVRVF 1034
+L +L Y ++ G V + L E + +SA D G L N++++VF
Sbjct: 500 RRLGERSL--SSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVF 557
Query: 1035 VKDVNDHFP-VFKKTWYNFNVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQP- 1086
V D ND+ P + + ++ R V+GKV A DAD G NA L+Y +QP
Sbjct: 558 VLDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPE 617
Query: 1087 -SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
+ +PF + TG +S LD + L V+ +D+G
Sbjct: 618 TASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHG 658
Score = 62.1 bits (144), Expect = 1e-08
Identities = 50/154 (32%), Positives = 70/154 (45%), Gaps = 16/154 (10%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGS-----LFLEKELDLDAEHNLQANTFVL 274
A D D+G A L Y L S N+ + + N L L K LD + L L
Sbjct: 160 ASDADIGENALLTYRL-SPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELH-----L 213
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A+ P T ++ I +LD NDN P F+ Y + + EN+ G V+ A+D D
Sbjct: 214 LLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLD 273
Query: 335 QGENGEFTYQLD-----DPKGAFSIDPRSGWLTV 363
+G NG+ Y D K F +DP SG +TV
Sbjct: 274 EGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITV 307
Score = 58.4 bits (135), Expect = 2e-07
Identities = 71/290 (24%), Positives = 114/290 (39%), Gaps = 18/290 (6%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L G +++ + + + + D NDN P+F T Y V + E G + +
Sbjct: 215 LTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDE 274
Query: 127 SLTIPLTVPRGLTIFKDIRA-FDRDKPNTPNSDVHYSIVSGNDDGHFALESSHK--PVL- 182
L + + DI++ F D + + + + + +E+ K P L
Sbjct: 275 GLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLA 334
Query: 183 ----LLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPI---HAIDQDLGVGATLRYEL 235
LL +V+D + D QL I + ++ I ID D + L
Sbjct: 335 GHCTLLVEVVDVN--DNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSL 392
Query: 236 ISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIE 295
KL S SL L++ LD ++ + + L V A +P A ARV +E
Sbjct: 393 TPHVPFKLVSTYKNYYSLVLDRALDRES-----VSAYELVVTARDGGSPSLWATARVSVE 447
Query: 296 LLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+ D+NDN P F Y + + EN P G + V A D D EN +Y L
Sbjct: 448 VADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL 497
Score = 56.4 bits (130), Expect = 7e-07
Identities = 77/344 (22%), Positives = 143/344 (41%), Gaps = 41/344 (11%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPT--------------GEKAFIFLIAPIGPSL 128
V V ++D+NDN P+F T ++ + E P GE A L + P+
Sbjct: 122 VDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADIGENAL--LTYRLSPNE 179
Query: 129 TIPLTVPRGLTIFKDIRAFDR---DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLR 185
L VP K + R D+ TP ++H +++ D G L + V LL
Sbjct: 180 YFFLDVPTSNQQVKPLGLVLRKLLDREETP--ELHL-LLTATDGGKPELTGT---VQLLI 233
Query: 186 KVLDYDAG----DKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL---ISG 238
VLD + D+ V + I ++ P +A D D G+ + Y +S
Sbjct: 234 TVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHP---NASDLDEGLNGDIIYSFSSDVSP 290
Query: 239 NDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLD 298
+ + F +D ++G++ + +D + ++ + V+A P + +E++D
Sbjct: 291 DIKSKFHMDPLSGAITVIGHMDFE-----ESRAHKIPVEAVDKGFPPLAGHCTLLVEVVD 345
Query: 299 LNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRS 358
+NDN P+ + ++ + E+ G + + D D NG+ T L +
Sbjct: 346 VNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTYK 405
Query: 359 GWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGTFADSQRIA 401
+ ++ LDRE+ S+ + V A++ +PS+ T S +A
Sbjct: 406 NYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVA 449
Score = 54.0 bits (124), Expect = 4e-06
Identities = 62/219 (28%), Positives = 96/219 (43%), Gaps = 23/219 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ E+ +GT I ++ +DLD+ NGQ+ V P KL + K Y+ +
Sbjct: 362 VKEDAQLGTVIALISVIDLDADANGQVTCSLTPHV---PFKLVST---YKNYYSL----- 410
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
++ R+L ES + L ++A DGG+ L V V V DVND+ P F ++ Y V+
Sbjct: 411 --VLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVK 468
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTDLPFEIS--PLTGVLSVNGELDR 1110
E + V A DAD +NA ++Y + + + L +S +G + LD
Sbjct: 469 ENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDH 528
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
E + V ARD G D NDN+P
Sbjct: 529 EELELLQFQVSARDAG-VPPLGSNVTLQVFVLDENDNAP 566
Score = 52.8 bits (121), Expect = 9e-06
Identities = 55/205 (26%), Positives = 90/205 (43%), Gaps = 13/205 (6%)
Query: 700 IFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIAE-----DGTIFTQKPLDREKRDVYRM 754
+ H N S + G++ + ++ DV+ DI G I +D E+ +++
Sbjct: 264 VIHPNASDLDEGLNGDIIYSFSS--DVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKI 321
Query: 755 TVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKA 814
V A +KG AG + + + D NDN P T + E++++GT I + ++I
Sbjct: 322 PVEA-VDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDL 380
Query: 815 TDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLS 874
DAD T K + +V + +LDRE Y+L + ARD G S
Sbjct: 381 -DADANGQVTCSLTPHVPFKLVSTYKNYYSLV--LDRALDRESVSAYELVVTARDGGSPS 437
Query: 875 --SEAELIIMIGDENDNKPEFNQIE 897
+ A + + + D NDN P F Q E
Sbjct: 438 LWATARVSVEVADVNDNAPAFAQSE 462
Score = 48.0 bits (109), Expect = 3e-04
Identities = 56/184 (30%), Positives = 85/184 (46%), Gaps = 17/184 (9%)
Query: 221 IDQDLGVG-ATL---RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQ 275
I QDLG+ A L ++L S L ++ NG LF+ +D + A + L+
Sbjct: 51 IAQDLGLELAELVPRLFQLDSKGRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLE 110
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQ 335
V ++ PL+ V++E+ D+NDN P F N+ I E+ P A+D D
Sbjct: 111 VI---VDRPLQVFH--VDVEVKDINDNPPVFPATQKNLFIAESRPLDSRFPLEGASDADI 165
Query: 336 GENGEFTYQLDDPKGAFSID-PRSGW----LTVRNQTVLDREAHSSLRMKVYAKE-TNPS 389
GEN TY+L P F +D P S L + + +LDRE L + + A + P
Sbjct: 166 GENALLTYRL-SPNEYFFLDVPTSNQQVKPLGLVLRKLLDREETPELHLLLTATDGGKPE 224
Query: 390 VVGT 393
+ GT
Sbjct: 225 LTGT 228
Score = 42.7 bits (96), Expect = 0.010
Identities = 40/156 (25%), Positives = 72/156 (46%), Gaps = 24/156 (15%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L++TV D D + PVF Y +++ ENV+ ++ N ++ E
Sbjct: 221 GKPELTGTVQLLITVLDNND-----NAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEG 275
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRAERQKYSRELP 1345
N + Y ++ DI+ F +DP +G + ++ D E +++ V A + +
Sbjct: 276 LNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFP---- 331
Query: 1346 HMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFT 1381
P+A ++V + DVNDN+P+ T
Sbjct: 332 ----PLAG---------HCTLLVEVVDVNDNAPQLT 354
Score = 42.3 bits (95), Expect = 0.013
Identities = 81/347 (23%), Positives = 135/347 (38%), Gaps = 30/347 (8%)
Query: 70 IGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEK----AFIFLIAPIG 125
+ G ++ + ++ V + DVNDN P V V E G + I L A
Sbjct: 326 VDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADAN 385
Query: 126 PSLTIPLT--VPRGL-TIFKDIRAFDRDKPNTPNSDVHYS-IVSGNDDGHFALESSHKPV 181
+T LT VP L + +K+ + D+ S Y +V+ D G +L ++ +
Sbjct: 386 GQVTCSLTPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVS 445
Query: 182 LLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGN-- 239
+ + V D + + + +F + A D D A + Y L+
Sbjct: 446 VEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFT--VSARDADAQENALVSYSLVERRLG 503
Query: 240 DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIEL 296
+R L S SV+ G ++ + LD + LQ QV A P + +++ +
Sbjct: 504 ERSLSSYVSVHAESGKVYALQPLDHEELELLQ-----FQVSARDAGVPPLGSNVTLQVFV 558
Query: 297 LDLNDNLPEFEVDFYN-----IS--IVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
LD NDN P +S ++ ++ G V +V A D D G N +Y+L
Sbjct: 559 LDENDNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPET 618
Query: 350 GAFSIDPRSGWLT--VRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
+ SI R G T + LD R+ V K+ P++ T
Sbjct: 619 ASASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHGEPALTAT 665
Score = 36.3 bits (80), Expect = 0.85
Identities = 20/62 (32%), Positives = 34/62 (54%), Gaps = 5/62 (8%)
Query: 1429 ERLSLNGLT-SPQATDSDIGINADIRYQILNEQAP----RFAIDPVSGTVRVVAALARDA 1483
E +S+ L P A+D D G+N DI Y ++ +P +F +DP+SG + V+ + +
Sbjct: 256 ENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFEE 315
Query: 1484 GR 1485
R
Sbjct: 316 SR 317
>AY358428-1|AAQ88794.1| 1184|Homo sapiens PCDH12 protein.
Length = 1184
Score = 102 bits (244), Expect = 1e-20
Identities = 126/545 (23%), Positives = 225/545 (41%), Gaps = 32/545 (5%)
Query: 440 MSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDL 499
++ ++VE+ +LD ND+ P F P E + +A + T I +A+DPD G N + Y L
Sbjct: 116 LALIHVEIQVLDINDHQPRF-PKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTL 174
Query: 500 QRTSNLTITSPFKINPNTGTVSVAESPILEGRHALF--VEASDQPANPSERRYSLAVVTI 557
+ + + + + + H+ F V + NP + SL V +
Sbjct: 175 SPSEHFALDVIVGPDETKHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNV 234
Query: 558 EVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGYE 615
+ + P F + + + GT + ++ D + +V + L
Sbjct: 235 ------LDSNDNSPAFAESSLALEIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMP 288
Query: 616 EGV--PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENAN-LSIVTNATVHVVDVNDE 672
V F+++ ++G + + L P Y+ + A N + + V+DVND
Sbjct: 289 PEVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQARDLGPNPIPAHCKVLIKVLDVNDN 348
Query: 673 -RGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
+ + A P + + + I + ++ S + NG + +L
Sbjct: 349 IPSIHVTWASQPSLVS-EALPKDSFIALVMADDLDSGH-NGLVHC-WLSQELGHFRLKRT 405
Query: 732 IAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
+ T LDRE+ Y +T++A+ ++G+ + Q++I I D NDN PVFE +
Sbjct: 406 NGNTYMLLTNATLDREQWPKYTLTLLAQ-DQGLQPLSAKKQLSIQISDINDNAPVFEKSR 464
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG-KEMFDVDENTGVVKFIG 850
YE EN+ + IKA DAD G N Y + + +D NTG V
Sbjct: 465 YEVSTRENNLPSLHL---ITIKAHDADLGINGKVSYRIQDSPVAHLVAIDSNTGEVT-AQ 520
Query: 851 DSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ-IEENSKVRIHRE 907
SL+ E+ ++ ++A D+G L+S + + + D NDN PE Q + + K +
Sbjct: 521 RSLNYEEMAGFEFQVIAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASL--S 578
Query: 908 TKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIR 967
+N + G ++ ++ N PL + TTI+ A D DSG NG+
Sbjct: 579 VLVNASTGHLLVPIETPNGLGPAGTDTPPLATHSSRPFLLTTIV---ARDADSGANGEPL 635
Query: 968 YEFNS 972
Y +
Sbjct: 636 YSIRN 640
Score = 89.8 bits (213), Expect = 6e-17
Identities = 117/426 (27%), Positives = 179/426 (42%), Gaps = 53/426 (12%)
Query: 733 AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATY 792
+E+G + T + LDRE+ + F+ + V I + D ND+ P F
Sbjct: 81 SEEGLLSTGRRLDREQLCRQWDPCLVSFDVLATGDLALIHVEIQVLDINDHQPRFPKGEQ 140
Query: 793 EGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDS 852
E I E++ + T I +D +A D D G N L YTL E F +D G
Sbjct: 141 ELEISESASLRTRIPLD---RALDPDTGPNTLHTYTL--SPSEHFALDVIVGP------- 188
Query: 853 LDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNG 912
D K +L +V + S +L++ D N N P+ S V+++ +
Sbjct: 189 -DETKHA--ELIVVKELDREIHSFFDLVLTAYD-NGNPPKSG----TSLVKVNVLDSNDN 240
Query: 913 TAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNS 972
+ F ++ AL++ E+ GT +IKL A D D G NG++ EF
Sbjct: 241 SPAFA------ESSLALEIQ---------EDAAPGTLLIKLTATDPDQGPNGEV--EFFL 283
Query: 973 EVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALD-GGN-LNDN 1028
++PP EV F I+ + G VI+ R L E + +++ A D G N + +
Sbjct: 284 SKHMPP--------EVLDTFSIDAKTGQVILRRPLDYEKNPAYEVDVQARDLGPNPIPAH 335
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYN--FNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQP 1086
V + V DVND+ P TW + V EA + V A D D G N + ++
Sbjct: 336 CKVLIKVLDVNDNIPSIHVTWASQPSLVSEALPKDSFIALVMADDLDSGHNGLVHCWLSQ 395
Query: 1087 SDTDLPFE-ISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
+ + T +L N LDRE KY LT++A+D G D+N
Sbjct: 396 ELGHFRLKRTNGNTYMLLTNATLDREQWPKYTLTLLAQDQG-LQPLSAKKQLSIQISDIN 454
Query: 1146 DNSPKF 1151
DN+P F
Sbjct: 455 DNAPVF 460
Score = 74.9 bits (176), Expect = 2e-12
Identities = 125/506 (24%), Positives = 205/506 (40%), Gaps = 66/506 (13%)
Query: 997 RHGHVIVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+H +IV + L E S F L ++A D GN + V+V V D ND+ P F ++
Sbjct: 192 KHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLAL 251
Query: 1053 NVEEAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTDLPFEISPLTGVLSVNGELD 1109
++E +L K+ ATD D G N + +F+ P + F I TG + + LD
Sbjct: 252 EIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQVILRRPLD 311
Query: 1110 RETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFYAFDELLEW-KHPE--AD 1166
E Y + V ARD G DVNDN P + + W P ++
Sbjct: 312 YEKNPAYEVDVQARDLG-PNPIPAHCKVLIKVLDVNDNIPSIH-----VTWASQPSLVSE 365
Query: 1167 ELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNG-LILYSLPQRKNQ- 1224
L +F +++M + N + +++ + NGN ++L + + Q
Sbjct: 366 ALPKDSFIALVMADDLDS--GHNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDREQW 423
Query: 1225 ---------QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVE 1275
Q+ GL LS+ L + ++D+ D + PVF YE+ EN +
Sbjct: 424 PKYTLTLLAQDQGLQPLSAKKQLSIQISDIND-----NAPVFEKSRYEVSTRENNLPSLH 478
Query: 1276 LVSLNL--TEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIV 1333
L+++ + N K+ Y I D+ + ID G + RS + E +E V
Sbjct: 479 LITIKAHDADLGINGKVSYRI---QDSPVAHLVAIDSNTGEVTAQRSLNYEEMAGFEFQV 535
Query: 1334 RAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSPKFTN---GNRPLVTA 1390
+AED + M V V V + D NDN+P+ + +
Sbjct: 536 -----------------IAEDSGQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASLS 578
Query: 1391 IPTTAPFGYQVMQLKGAIGHHPTASRTVRADTDELVFFERLSLNGLTSPQATDSDIGINA 1450
+ A G+ ++ ++ G P + T T R L LT+ A D+D G N
Sbjct: 579 VLVNASTGHLLVPIETPNGLGPAGTDTPPLATHS----SRPFL--LTTIVARDADSGANG 632
Query: 1451 DIRYQILN-EQAPRFAIDPVSGTVRV 1475
+ Y I N +A F ++P +G + V
Sbjct: 633 EPLYSIRNGNEAHLFILNPHTGQLFV 658
Score = 65.3 bits (152), Expect = 2e-09
Identities = 129/540 (23%), Positives = 213/540 (39%), Gaps = 49/540 (9%)
Query: 31 HVSVILAQSIDSLVDSDSPQNVVKFRLGCDFDEGDDLVRIGA--GLNQISAYLSVTVYIE 88
H +I+ + +D + S + + G G LV++ + A+ ++ +E
Sbjct: 193 HAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALE 252
Query: 89 DVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSL--TIPLTVPRGLTIFKDIRA 146
D P L T + P GE F FL + P + T + G I + R
Sbjct: 253 IQEDAAPGTLLIKLTATDPDQGPNGEVEF-FLSKHMPPEVLDTFSIDAKTGQVILR--RP 309
Query: 147 FDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDYDAGDKEFQLVIMASGK 206
D +K P +V V D G + + H VL+ KVLD + V AS
Sbjct: 310 LDYEK--NPAYEVD---VQARDLGPNPIPA-HCKVLI--KVLDVNDNIPSIH-VTWASQP 360
Query: 207 RIHKEILFPEPIHAI--DQDLGVGATLRYELISGNDRKLFSLDSVNGSLF-LEKELDLDA 263
+ E L + A+ DL G + F L NG+ + L LD
Sbjct: 361 SLVSEALPKDSFIALVMADDLDSGHNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDR 420
Query: 264 EHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGF 323
E T L Q L PL +A+ ++ I++ D+NDN P FE Y +S EN
Sbjct: 421 EQ-WPKYTLTLLAQDQGLQ-PL-SAKKQLSIQISDINDNAPVFEKSRYEVSTRENNLPSL 477
Query: 324 SVLQVMATDKDQGENGEFTYQLDDPKGA--FSIDPRSGWLTVRNQTVLDREAHSSLRMKV 381
++ + A D D G NG+ +Y++ D A +ID +G +T Q L+ E + +V
Sbjct: 478 HLITIKAHDADLGINGKVSYRIQDSPVAHLVAIDSNTGEVTA--QRSLNYEEMAGFEFQV 535
Query: 382 YAKETNPSVVGTFADSQRIAKW-RRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLM 440
A+++ ++ + ++ W NAP E V D + + + L+
Sbjct: 536 IAEDSGQPML-----ASSVSVWVSLLDANDNAP-EVVQPVLSDGKASLSVLVNASTGHLL 589
Query: 441 SFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQ 500
+ L A + P + F + T++ + D D G NG LY ++
Sbjct: 590 VPIETPNGLGPAGTDTPPLATHSSRPFLLT------TIVAR----DADSGANGEPLYSIR 639
Query: 501 RTSNLTITSPFKINPNTGT--VSVAESPILEGRH-ALFVEASDQPANPSERRYSLAVVTI 557
+ + F +NP+TG V+V + L G L + DQ + P + R L V+ +
Sbjct: 640 NGNEAHL---FILNPHTGQLFVNVTNASSLIGSEWELEIVVEDQGSPPLQTRALLRVMFV 696
Score = 62.1 bits (144), Expect = 1e-08
Identities = 76/337 (22%), Positives = 145/337 (43%), Gaps = 37/337 (10%)
Query: 579 EFWVGSNVGIGTSVGQIRVNDAFE----QNDVSYDLLHGYEEGVPFAVEERSGVITVVDD 634
++ V V GT +G++ E Q ++ +L + +P V+ G+++
Sbjct: 33 KYQVSEEVPSGTVIGKLSQELGREERRRQAGAAFQVLQ-LPQALPIQVDSEEGLLSTGRR 91
Query: 635 LSR------YNRPMYDFEAVALQENANLSIVTNATVHVVDVNDERGVLLKGAHSPIIFHV 688
L R ++ + F+ +A +L+++ + + V+D+ND + KG
Sbjct: 92 LDREQLCRQWDPCLVSFDVLA---TGDLALI-HVEIQVLDINDHQPRFPKGEQE------ 141
Query: 689 KENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLIANQQDVTDDIAIAEDGT----IFTQKP 743
E S A++ + + G + + ++ + D+ + D T + K
Sbjct: 142 LEISESASLRTRIPLDRALDPDTGPNTLHTYTLSPSEHFALDVIVGPDETKHAELIVVKE 201
Query: 744 LDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIG 803
LDRE + + V+ ++ G +G V + + D NDN P F ++ I E++ G
Sbjct: 202 LDREIHSFFDL-VLTAYDNGNPPKSGTSLVKVNVLDSNDNSPAFAESSLALEIQEDAAPG 260
Query: 804 TEIKMDNIIKATDADEGTNALFMYTLF----GEGKEMFDVDENTGVVKFIGDSLDREKKI 859
T + + ATD D+G N + L E + F +D TG V + LD EK
Sbjct: 261 TLLIK---LTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAKTGQV-ILRRPLDYEKNP 316
Query: 860 MYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFN 894
Y++ + ARD G + + +++I + D NDN P +
Sbjct: 317 AYEVDVQARDLGPNPIPAHCKVLIKVLDVNDNIPSIH 353
Score = 40.3 bits (90), Expect = 0.052
Identities = 35/112 (31%), Positives = 50/112 (44%), Gaps = 7/112 (6%)
Query: 288 AQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD 347
A VEI++LD+ND+ P F + I E+ + A D D G N TY L
Sbjct: 117 ALIHVEIQVLDINDHQPRFPKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTL-S 175
Query: 348 PKGAFSIDPRSGWLTVRNQTV-----LDREAHSSLRMKVYAKET-NPSVVGT 393
P F++D G ++ + LDRE HS + + A + NP GT
Sbjct: 176 PSEHFALDVIVGPDETKHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGT 227
>AF152501-1|AAD43762.2| 801|Homo sapiens protocadherin beta 8
protein.
Length = 801
Score = 102 bits (244), Expect = 1e-20
Identities = 133/508 (26%), Positives = 218/508 (42%), Gaps = 64/508 (12%)
Query: 929 LDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
+D++ P+FL + E+ P GT NA DLD G N N E YI
Sbjct: 125 IDINDHSPVFLDKQMLVKVSESSPPGTAFPLKNAEDLDIGQN-------NIENYIISPNS 177
Query: 982 SADALEVKRYFVINERHGHVIVARSLP--PESEFRLNISALDGGNLNDNISVRVFVK--D 1037
L KR ++ +++ +L E+E RL ++ALDGG+ + + +V+++ D
Sbjct: 178 YFRVLTRKRSD--GRKYPELVLDNALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVVD 235
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTY-FIQPSD-TDLPFEI 1095
VND+ P F++ +Y + E ++ KV ATD D G N ++Y Q SD F++
Sbjct: 236 VNDNAPEFQQPFYRVQISEDSPISFLVVKVSATDVDTGVNGEISYSLFQASDEISKTFKV 295
Query: 1096 SPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK--FYA 1153
LTG + + +LD E Y + + ARD G DVND++P+ A
Sbjct: 296 DFLTGEIRLKKQLDFEKFQSYEVNIEARDAG---GFSGKCTVLIQVIDVNDHAPEVTMSA 352
Query: 1154 FDELLEWKHPE--ADELSNHNFESVMMIPVYKATIEENAP--IGTTVAKVFANDTDFIGN 1209
F + PE S + +S + +I+E+ P + ++V + T+ +
Sbjct: 353 FTSPIPENAPETVVALFSVSDLDSGENGKI-SCSIQEDLPFLLKSSVGNFYTLLTETPLD 411
Query: 1210 GNGLILYSLPQRKNQQNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN 1269
Y++ +LG P L++ + V V+DV D + P F Y L + EN
Sbjct: 412 RESRAEYNV--TITVTDLGTPRLTTHLNMTVLVSDVND-----NAPAFTQTSYTLFVREN 464
Query: 1270 VNAPVELVSLNLTEHYE--NFKMRYYILNENDTDIRRTFV--IDPRNGTLYLVRSPDREV 1325
+ + + S++ T+ N ++ Y +L D + + I+ NG L+ +RS D E
Sbjct: 465 NSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINTDNGHLFALRSLDYEA 524
Query: 1326 KDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNSP----KFT 1381
+E V A R P + + V V + D NDNSP
Sbjct: 525 LQAFEFRVGAS----DRGSPAL-------------SSEALVRVLVLDANDNSPFVLYPLQ 567
Query: 1382 NGNRPLVTAIPTTAPFGYQVMQLKGAIG 1409
NG+ P +P A GY V ++ G
Sbjct: 568 NGSAPCTELVPRAAEPGYLVTKVVAVDG 595
Score = 101 bits (242), Expect = 2e-20
Identities = 116/470 (24%), Positives = 190/470 (40%), Gaps = 36/470 (7%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E F E+ ++D ND++PVF+ + + ++ GT A D D+GQN +
Sbjct: 112 ESPFEFFQAELQVIDINDHSPVFLDKQML-VKVSESSPPGTAFPLKNAEDLDIGQNNIEN 170
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHA---LFVEASDQPANPSERRYSLA 553
Y + S + + + + V ++ + A L + A D + P R A
Sbjct: 171 YIISPNSYFRVLTRKRSDGRKYPELVLDNALDREEEAELRLTLTALDGGSPP---RSGTA 227
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLL 611
V IEV + P+F Y + + I V ++ D ++SY L
Sbjct: 228 QVYIEVV----DVNDNAPEFQQPFYRVQISEDSPISFLVVKVSATDVDTGVNGEISYSLF 283
Query: 612 HGYEE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
+E F V+ +G I + L Y+ A ++ S + V+DVN
Sbjct: 284 QASDEISKTFKVDFLTGEIRLKKQLDFEKFQSYEVNIEA-RDAGGFSGKCTVLIQVIDVN 342
Query: 671 DERG-VLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
D V + SPI EN+ + +F ++S + G + I
Sbjct: 343 DHAPEVTMSAFTSPI----PENAPETVVA-LF--SVSDLDSGENGKISCSIQEDLPFLLK 395
Query: 730 IAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEH 789
++ T+ T+ PLDRE R Y +T+ + G +T+ + D NDN P F
Sbjct: 396 SSVGNFYTLLTETPLDRESRAEYNVTITVT-DLGTPRLTTHLNMTVLVSDVNDNAPAFTQ 454
Query: 790 ATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEG------KEMFDVDENT 843
+Y F+ EN+ I + ATD D GTNA Y+L + ++ +
Sbjct: 455 TSYTLFVRENNSPALHI---GSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINTDN 511
Query: 844 GVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
G + F SLD E ++ + A D G LSSEA + +++ D NDN P
Sbjct: 512 GHL-FALRSLDYEALQAFEFRVGASDRGSPALSSEALVRVLVLDANDNSP 560
Score = 83.4 bits (197), Expect = 6e-15
Identities = 81/307 (26%), Positives = 133/307 (43%), Gaps = 20/307 (6%)
Query: 662 ATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVR-FLI 720
A + V+D+ND V L ++ V E+S G F + G N+ ++I
Sbjct: 120 AELQVIDINDHSPVFLD---KQMLVKVSESSPP---GTAFPLKNAEDLDIGQNNIENYII 173
Query: 721 ANQQDVTDDIAIAEDGTIFTQ----KPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIY 776
+ DG + + LDRE+ R+T+ A + G +G QV I
Sbjct: 174 SPNSYFRVLTRKRSDGRKYPELVLDNALDREEEAELRLTLTA-LDGGSPPRSGTAQVYIE 232
Query: 777 IEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEM 836
+ D NDN P F+ Y I E+S I + + ATD D G N Y+LF E+
Sbjct: 233 VVDVNDNAPEFQQPFYRVQISEDSPISFLVVK---VSATDVDTGVNGEISYSLFQASDEI 289
Query: 837 ---FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEF 893
F VD TG ++ + LD EK Y++++ ARD GG S + ++I + D ND+ PE
Sbjct: 290 SKTFKVDFLTGEIR-LKKQLDFEKFQSYEVNIEARDAGGFSGKCTVLIQVIDVNDHAPEV 348
Query: 894 NQIEENSKVRIHRETKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKL 953
S + + + + ++ K + + + P FL+ ++ T++
Sbjct: 349 TMSAFTSPIPENAPETVVALFSVSDLDSGENGKISCSIQEDLP-FLLKSSVGNFYTLLTE 407
Query: 954 NALDLDS 960
LD +S
Sbjct: 408 TPLDRES 414
Score = 81.0 bits (191), Expect = 3e-14
Identities = 70/246 (28%), Positives = 108/246 (43%), Gaps = 22/246 (8%)
Query: 911 NGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEF 970
+GTA IEV N A + Q I E+ PI ++K++A D+D+G+NG+I Y
Sbjct: 224 SGTAQ-VYIEVVDVNDNAPEFQQPFYRVQISEDSPISFLVVKVSATDVDTGVNGEISY-- 280
Query: 971 NSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDN 1028
L + E+ + F ++ G + + + L E + +NI A D G +
Sbjct: 281 ---------SLFQASDEISKTFKVDFLTGEIRLKKQLDFEKFQSYEVNIEARDAGGFSGK 331
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD 1088
+V + V DVNDH P + + + E V+ +D D G+N ++ IQ
Sbjct: 332 CTVLIQVIDVNDHAPEVTMSAFTSPIPE-NAPETVVALFSVSDLDSGENGKISCSIQ--- 387
Query: 1089 TDLPFEISPLTG---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVN 1145
DLPF + G L LDRE+ +Y +T+ D G DVN
Sbjct: 388 EDLPFLLKSSVGNFYTLLTETPLDRESRAEYNVTITVTDLG-TPRLTTHLNMTVLVSDVN 446
Query: 1146 DNSPKF 1151
DN+P F
Sbjct: 447 DNAPAF 452
Score = 78.2 bits (184), Expect = 2e-13
Identities = 54/173 (31%), Positives = 88/173 (50%), Gaps = 11/173 (6%)
Query: 219 HAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELD--LDAEHNLQANTFVLQV 276
+A D D+G Y + + ++ + +G + E LD LD E + L +
Sbjct: 157 NAEDLDIGQNNIENYIISPNSYFRVLTRKRSDGRKYPELVLDNALDREEEAELR---LTL 213
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
A +P ++ A+V IE++D+NDN PEF+ FY + I E+ P F V++V ATD D G
Sbjct: 214 TALDGGSPPRSGTAQVYIEVVDVNDNAPEFQQPFYRVQISEDSPISFLVVKVSATDVDTG 273
Query: 337 ENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
NGE +Y L D+ F +D +G + ++ Q LD E S + + A++
Sbjct: 274 VNGEISYSLFQASDEISKTFKVDFLTGEIRLKKQ--LDFEKFQSYEVNIEARD 324
Score = 66.1 bits (154), Expect = 9e-10
Identities = 77/317 (24%), Positives = 129/317 (40%), Gaps = 26/317 (8%)
Query: 80 YLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAP---IGPS-----LTIP 131
+ + + D+ND+ P+FLD V V E +P G AF A IG + + P
Sbjct: 117 FFQAELQVIDINDHSPVFLDKQMLVKVSESSPPGT-AFPLKNAEDLDIGQNNIENYIISP 175
Query: 132 LTVPRGLTIFK-DIRAFDR---DKPNTPNSDVHYSIVSGNDDGHFALESSHKPVLLLRKV 187
+ R LT + D R + D + + DG S V + +V
Sbjct: 176 NSYFRVLTRKRSDGRKYPELVLDNALDREEEAELRLTLTALDGGSPPRSGTAQVYI--EV 233
Query: 188 LDYDAGDKEFQLVIMASGKRIHKEILF-PEPIHAIDQDLGVGATLRYELISGNDR--KLF 244
+D + EFQ I F + A D D GV + Y L +D K F
Sbjct: 234 VDVNDNAPEFQQPFYRVQISEDSPISFLVVKVSATDVDTGVNGEISYSLFQASDEISKTF 293
Query: 245 SLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLP 304
+D + G + L+K+LD + + + N ++A + + V I+++D+ND+ P
Sbjct: 294 KVDFLTGEIRLKKQLDFEKFQSYEVN-----IEARDAGG--FSGKCTVLIQVIDVNDHAP 346
Query: 305 EFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLTVR 364
E + + I EN P L +D D GENG+ + + + + T+
Sbjct: 347 EVTMSAFTSPIPENAPETVVAL-FSVSDLDSGENGKISCSIQEDLPFLLKSSVGNFYTLL 405
Query: 365 NQTVLDREAHSSLRMKV 381
+T LDRE+ + + +
Sbjct: 406 TETPLDRESRAEYNVTI 422
Score = 63.7 bits (148), Expect = 5e-09
Identities = 57/181 (31%), Positives = 85/181 (46%), Gaps = 20/181 (11%)
Query: 218 IHAIDQDLGVGATLRYELISGND-----RKLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
+ A D+D G A + Y L+ D L S+++ NG LF + LD +A LQA F
Sbjct: 474 VSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINTDNGHLFALRSLDYEA---LQA--F 528
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNIS--IVENLPN----GFSVL 326
+V AS +P +++A V + +LD NDN P N S E +P G+ V
Sbjct: 529 EFRVGASDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVT 588
Query: 327 QVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAK 384
+V+A D D G+N +YQL G F + +G VR +L + R+ V K
Sbjct: 589 KVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNG--EVRTARLLSERDAAKQRLVVLVK 646
Query: 385 E 385
+
Sbjct: 647 D 647
Score = 57.2 bits (132), Expect = 4e-07
Identities = 59/200 (29%), Positives = 83/200 (41%), Gaps = 19/200 (9%)
Query: 937 LFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINE 996
LF+ N P I ++A D DSG N Q+ Y +PP L + IN
Sbjct: 459 LFVRENNSP-ALHIGSVSATDRDSGTNAQVTYSL-----LPPQD---PHLPLASLVSINT 509
Query: 997 RHGHVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNF 1052
+GH+ RSL E+ F + A D G+ L+ VRV V D ND+ P N
Sbjct: 510 DNGHLFALRSLDYEALQAFEFRVGASDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNG 569
Query: 1053 NVEEAQYTRR------VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNG 1106
+ + R ++ KV A D D GQNA L+Y + + F + G +
Sbjct: 570 SAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTAR 629
Query: 1107 ELDRETEDKYILTVVARDNG 1126
L K L V+ +DNG
Sbjct: 630 LLSERDAAKQRLVVLVKDNG 649
Score = 52.8 bits (121), Expect = 9e-06
Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 9/168 (5%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
E + + LDRE + + F + S +Q + + D ND+ PVF
Sbjct: 81 ETADLLLNEKLDREDLCGHTEPCVLRFQVLLESPFEFFQAELQVIDINDHSPVFLDKQML 140
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----I 849
+ E+S GT + N A D D G N + Y + + + K+ +
Sbjct: 141 VKVSESSPPGTAFPLKN---AEDLDIGQNNIENYIISPNSYFRVLTRKRSDGRKYPELVL 197
Query: 850 GDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
++LDRE++ +L+L A D G S A++ I + D NDN PEF Q
Sbjct: 198 DNALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVVDVNDNAPEFQQ 245
Score = 52.8 bits (121), Expect = 9e-06
Identities = 33/107 (30%), Positives = 49/107 (45%), Gaps = 4/107 (3%)
Query: 244 FSLDSVNGSLF-LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDN 302
F L S G+ + L E LD E + N + + + L P T + + + D+NDN
Sbjct: 392 FLLKSSVGNFYTLLTETPLDRESRAEYN---VTITVTDLGTPRLTTHLNMTVLVSDVNDN 448
Query: 303 LPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPK 349
P F Y + + EN + V ATD+D G N + TY L P+
Sbjct: 449 APAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQ 495
Score = 48.0 bits (109), Expect = 3e-04
Identities = 44/178 (24%), Positives = 74/178 (41%), Gaps = 9/178 (5%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I +K LD EK Y + + A + G SG V I + D ND+ P + +
Sbjct: 300 GEIRLKKQLDFEKFQSYEVNIEAR-DAGGFSGK--CTVLIQVIDVNDHAPEVTMSAFTSP 356
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDR 855
I EN+ T + + ++ +D D G N ++ + + LDR
Sbjct: 357 IPENAP-ETVVALFSV---SDLDSGENGKISCSIQEDLPFLLKSSVGNFYTLLTETPLDR 412
Query: 856 EKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
E + Y +++ D G L++ + +++ D NDN P F Q VR + L+
Sbjct: 413 ESRAEYNVTITVTDLGTPRLTTHLNMTVLVSDVNDNAPAFTQTSYTLFVRENNSPALH 470
Score = 47.6 bits (108), Expect = 3e-04
Identities = 38/121 (31%), Positives = 48/121 (39%), Gaps = 5/121 (4%)
Query: 1035 VKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFE 1094
V D+NDH PVF V E+ +A D D GQN Y I P+
Sbjct: 124 VIDINDHSPVFLDKQMLVKVSESSPPGTAFPLKNAEDLDIGQNNIENYIISPNSYFRVLT 183
Query: 1095 ISPLTG----VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
G L ++ LDRE E + LT+ A D G DVNDN+P+
Sbjct: 184 RKRSDGRKYPELVLDNALDREEEAELRLTLTALDGG-SPPRSGTAQVYIEVVDVNDNAPE 242
Query: 1151 F 1151
F
Sbjct: 243 F 243
Score = 37.1 bits (82), Expect = 0.48
Identities = 34/111 (30%), Positives = 51/111 (45%), Gaps = 8/111 (7%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSN------AKVGTVIGKVKAVDPDLGQN 492
L S V V +LDANDN+P FV L S A+ G ++ KV AVD D GQN
Sbjct: 542 LSSEALVRVLVLDANDNSP-FVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN 600
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVS-VAESPILEGRHALFVEASDQP 542
+ Y L + + + + N T ++E + R + V+ + +P
Sbjct: 601 AWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKQRLVVLVKDNGEP 651
Score = 36.3 bits (80), Expect = 0.85
Identities = 15/36 (41%), Positives = 23/36 (63%)
Query: 73 GLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDE 108
G +++ +L++TV + DVNDN P F T Y + V E
Sbjct: 428 GTPRLTTHLNMTVLVSDVNDNAPAFTQTSYTLFVRE 463
Score = 35.1 bits (77), Expect = 2.0
Identities = 38/154 (24%), Positives = 67/154 (43%), Gaps = 10/154 (6%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
++S ++ L+ L L ++LD + VL+ Q L +P + QA E+
Sbjct: 67 VVSRGNKLHLQLNQETADLLLNEKLDREDLCG-HTEPCVLRFQVL-LESPFEFFQA--EL 122
Query: 295 ELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKGAFSI 354
+++D+ND+ P F + + E+ P G + A D D G+N Y + P F +
Sbjct: 123 QVIDINDHSPVFLDKQMLVKVSESSPPGTAFPLKNAEDLDIGQNNIENY-IISPNSYFRV 181
Query: 355 DPRS-----GWLTVRNQTVLDREAHSSLRMKVYA 383
R + + LDRE + LR+ + A
Sbjct: 182 LTRKRSDGRKYPELVLDNALDREEEAELRLTLTA 215
>BC103928-1|AAI03929.1| 810|Homo sapiens protocadherin gamma
subfamily B, 1 protein.
Length = 810
Score = 101 bits (243), Expect = 2e-20
Identities = 115/468 (24%), Positives = 211/468 (45%), Gaps = 39/468 (8%)
Query: 436 DEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMV 495
D L ++ + + DANDN PVF +Y S++ N GT + +V A D D G N +
Sbjct: 216 DPPLSGTTHIWIRVTDANDNAPVF-SQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEI 274
Query: 496 LYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASDQPANPSERRYSLA 553
Y ++ TS F +NPNTG ++ + E R+ L VEA D + + +
Sbjct: 275 TYAF--LNSPISTSLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGVHTAHCNVQIE 332
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHG 613
+V N P++ FM + + + +GT + I+V D ++ ++
Sbjct: 333 IV------DENDNAPEV-TFMS--FSNQIPEDSDLGTVIALIKVRD---KDSGQNGMVTC 380
Query: 614 Y-EEGVPFAVEERSG---VITVVDDLSRYNRPMYDFEAVALQE-NANLSIVTNATVHVVD 668
Y +E VPF +E S + + L+R Y+ +A + LS T+ T+H+ D
Sbjct: 381 YTQEEVPFKLESTSKNYYKLVIAGALNREQTADYNVTIIATDKGKPALSSRTSITLHISD 440
Query: 669 VNDERGVLLKGAHSPIIFHVKENS-AGAAIGQIFHTNMSSIYGNGTGNVRFLIAN--QQD 725
+ND V + ++ + HV EN+ GA+I Q+ ++ + N + L ++ ++
Sbjct: 441 INDNAPVFHQASY---VVHVSENNPPGASIAQVSASD-PDLGPNDRVSYSILASDLEPRE 496
Query: 726 VTDDIAIA-EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNP 784
+ ++++ + G +F Q+ D E+ + +T+ A ++G + + + + + D NDN
Sbjct: 497 LLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQAR-DQGSPALSANVSLRVLVGDLNDNA 555
Query: 785 P--VFEHATYEGFIMEN--SKIGTEIKMDNIIKATDADEGTNALFMY-TLFGEGKEMFDV 839
P ++ +G + + + + + A DAD G NA Y L +F +
Sbjct: 556 PRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSL 615
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGD 885
TG V+ DR+ +L + RD G LS+ A L ++ D
Sbjct: 616 GLRTGEVRTARALGDRD-AARQRLLVAVRDGGQPPLSATATLHLIFAD 662
Score = 99.1 bits (236), Expect = 1e-19
Identities = 119/468 (25%), Positives = 194/468 (41%), Gaps = 32/468 (6%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E M+ +V V + D NDN P FV + + + +A G A D D+ N + L
Sbjct: 108 ENPMNVFHVVVVIQDINDNAPRFVAKGI-DLEICESALPGVKFSLDSAQDADVEGNSLKL 166
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPI---LEGRHALFVEASDQPANPSERRYSLA 553
Y + ++++ + + V + E P+ + H L + A D P L+
Sbjct: 167 YTINPNQYFSLSTKESPDGSKYPVLLLEKPLDREHQSSHRLILTAMDGGDPP------LS 220
Query: 554 VVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLL 611
T R T N + P F Y + NV GTSV ++ D E +++Y L
Sbjct: 221 GTTHIWIRVTDAND-NAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFL 279
Query: 612 HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVND 671
+ F + +G IT L Y +V ++ + N + +VD ND
Sbjct: 280 NSPISTSLFNLNPNTGDITTNGTLDFEETSRYVL-SVEAKDGGVHTAHCNVQIEIVDEND 338
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIA 731
+ + S I +++ G I I + S G V + +
Sbjct: 339 NAPEVTFMSFSNQI--PEDSDLGTVIALIKVRDKDS---GQNGMVTCYTQEEVPFKLEST 393
Query: 732 IAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHAT 791
+ L+RE+ Y +T+IA +KG + + +T++I D NDN PVF A+
Sbjct: 394 SKNYYKLVIAGALNREQTADYNVTIIAT-DKGKPALSSRTSITLHISDINDNAPVFHQAS 452
Query: 792 YEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEMF---DVDENTGV 845
Y + EN+ G I + A+D D G N Y++ E +E+ V +GV
Sbjct: 453 YVVHVSENNPPGASIAQ---VSASDPDLGPNDRVSYSILASDLEPRELLSYVSVSPQSGV 509
Query: 846 VKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V F + D E+ ++L+L ARD G LS+ L +++GD NDN P
Sbjct: 510 V-FAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAP 556
Score = 87.0 bits (206), Expect = 5e-16
Identities = 95/350 (27%), Positives = 162/350 (46%), Gaps = 39/350 (11%)
Query: 1010 ESEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKV 1067
+S RL ++A+DGG+ L+ + + V D ND+ PVF + Y +++E + +V
Sbjct: 202 QSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQENVPWGTSVLRV 261
Query: 1068 DATDADFGQNANLTY-FIQ-PSDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
ATD D G NA +TY F+ P T L F ++P TG ++ NG LD E +Y+L+V A+D
Sbjct: 262 MATDQDEGINAEITYAFLNSPISTSL-FNLNPNTGDITTNGTLDFEETSRYVLSVEAKDG 320
Query: 1126 GXXXXXXXXXXXXXXXXDVNDNSPK--FYAFDELLEWKHPEADELSNHNFESVMMIPVYK 1183
G D NDN+P+ F +F + PE +L + +I V
Sbjct: 321 G---VHTAHCNVQIEIVDENDNAPEVTFMSFSNQI----PEDSDLGT----VIALIKVRD 369
Query: 1184 ATIEENAPIGT-TVAKVFANDTDFIGNGNGLILYSLPQRKNQQNL---------GLPSLS 1233
+N + T +V N L++ R+ + G P+LS
Sbjct: 370 KDSGQNGMVTCYTQEEVPFKLESTSKNYYKLVIAGALNREQTADYNVTIIATDKGKPALS 429
Query: 1234 STAILMVTVADVPDEVEMSDKPVFISRYYELEIEEN--VNAPVELVSLNLTEHYENFKMR 1291
S + + ++D+ D + PVF Y + + EN A + VS + + N ++
Sbjct: 430 SRTSITLHISDIND-----NAPVFHQASYVVHVSENNPPGASIAQVSASDPDLGPNDRVS 484
Query: 1292 YYILNENDTDIRR--TFV-IDPRNGTLYLVRSPDREVKDTYEVIVRAERQ 1338
Y IL +D + R ++V + P++G ++ R+ D E +E+ ++A Q
Sbjct: 485 YSIL-ASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARDQ 533
Score = 86.6 bits (205), Expect = 6e-16
Identities = 59/171 (34%), Positives = 86/171 (50%), Gaps = 13/171 (7%)
Query: 738 IFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIM 797
+ +KPLDRE + +R+ ++ + G +G + I + D NDN PVF Y +
Sbjct: 191 LLLEKPLDREHQSSHRL-ILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQ 249
Query: 798 ENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGE--GKEMFDVDENTGVVKFIGDSLDR 855
EN GT + + ATD DEG NA Y +F+++ NTG + G +LD
Sbjct: 250 ENVPWGTSVLR---VMATDQDEGINAEITYAFLNSPISTSLFNLNPNTGDITTNG-TLDF 305
Query: 856 EKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEF------NQIEENS 900
E+ Y LS+ A+D G ++ + I I DENDN PE NQI E+S
Sbjct: 306 EETSRYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDS 356
Score = 86.6 bits (205), Expect = 6e-16
Identities = 78/266 (29%), Positives = 123/266 (46%), Gaps = 26/266 (9%)
Query: 897 EENSKVRIHRETKLNG--TAGFTI-IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKL 953
EE S+ + E K G TA + IE+ +N A +V + IPE+ +GT I +
Sbjct: 306 EETSRYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDSDLGTVIALI 365
Query: 954 NALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPE--S 1011
D DSG NG + EV P KL + + K Y+ + ++A +L E +
Sbjct: 366 KVRDKDSGQNGMVTCYTQEEV---PFKLESTS---KNYYKL-------VIAGALNREQTA 412
Query: 1012 EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDA 1069
++ + I A D G L+ S+ + + D+ND+ PVF + Y +V E + +V A
Sbjct: 413 DYNVTIIATDKGKPALSSRTSITLHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSA 472
Query: 1070 TDADFGQNANLTYFIQPSDTD----LPF-EISPLTGVLSVNGELDRETEDKYILTVVARD 1124
+D D G N ++Y I SD + L + +SP +GV+ D E + LT+ ARD
Sbjct: 473 SDPDLGPNDRVSYSILASDLEPRELLSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARD 532
Query: 1125 NGXXXXXXXXXXXXXXXXDVNDNSPK 1150
G D+NDN+P+
Sbjct: 533 QG-SPALSANVSLRVLVGDLNDNAPR 557
Score = 77.4 bits (182), Expect = 4e-13
Identities = 58/218 (26%), Positives = 101/218 (46%), Gaps = 21/218 (9%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN+P GT+++++ A D D G+N +I Y F + S +S F +N G
Sbjct: 248 LQENVPWGTSVLRVMATDQDEGINAEITYAFLN------SPISTS------LFNLNPNTG 295
Query: 1000 HVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEA 1057
+ +L E S + L++ A DGG + +V++ + D ND+ P ++ + E
Sbjct: 296 DITTNGTLDFEETSRYVLSVEAKDGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPED 355
Query: 1058 QYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG---VLSVNGELDRETED 1114
V+ + D D GQN +T + Q ++PF++ + L + G L+RE
Sbjct: 356 SDLGTVIALIKVRDKDSGQNGMVTCYTQ---EEVPFKLESTSKNYYKLVIAGALNREQTA 412
Query: 1115 KYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY 1152
Y +T++A D G D+NDN+P F+
Sbjct: 413 DYNVTIIATDKG-KPALSSRTSITLHISDINDNAPVFH 449
Score = 77.0 bits (181), Expect = 5e-13
Identities = 60/170 (35%), Positives = 89/170 (52%), Gaps = 12/170 (7%)
Query: 223 QDLGV-GATLRYELISGNDR-KLFSLDSVNGSLF--LEKELDLDAEHNLQANTFVLQVQA 278
QD V G +L+ I+ N L + +S +GS + L E LD EH ++ L + A
Sbjct: 155 QDADVEGNSLKLYTINPNQYFSLSTKESPDGSKYPVLLLEKPLDREHQ---SSHRLILTA 211
Query: 279 SQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGEN 338
+P + + I + D NDN P F + Y +S+ EN+P G SVL+VMATD+D+G N
Sbjct: 212 MDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGIN 271
Query: 339 GEFTYQ-LDDP--KGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
E TY L+ P F+++P +G +T LD E S + V AK+
Sbjct: 272 AEITYAFLNSPISTSLFNLNPNTGDITTNG--TLDFEETSRYVLSVEAKD 319
Score = 68.5 bits (160), Expect = 2e-10
Identities = 67/245 (27%), Positives = 107/245 (43%), Gaps = 18/245 (7%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
E G + +DREK ++ EF + ++ V + I+D NDN P F +
Sbjct: 77 ESGDLLVNGRIDREKICGRKLECALEFETVAENPMNVFHVVVVIQDINDNAPRFVAKGID 136
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----I 849
I E++ G + +D+ A DAD N+L +YT+ E+ K+ +
Sbjct: 137 LEICESALPGVKFSLDS---AQDADVEGNSLKLYTINPNQYFSLSTKESPDGSKYPVLLL 193
Query: 850 GDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRE 907
LDRE + ++L L A D G LS + I + D NDN P F+Q E +V +
Sbjct: 194 EKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQ--EVYRVSLQE- 250
Query: 908 TKLNGTAGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIR 967
N G +++ V ++ ++ FL N PI T++ LN D NG +
Sbjct: 251 ---NVPWGTSVLRVMATDQDEGINAEITYAFL---NSPISTSLFNLNPNTGDITTNGTLD 304
Query: 968 YEFNS 972
+E S
Sbjct: 305 FEETS 309
Score = 67.3 bits (157), Expect = 4e-10
Identities = 55/164 (33%), Positives = 80/164 (48%), Gaps = 12/164 (7%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I T LD E+ Y ++V E G + A V I I DENDN P ++
Sbjct: 295 GDITTNGTLDFEETSRYVLSV--EAKDGGVHTAHC-NVQIEIVDENDNAPEVTFMSFSNQ 351
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENT-GVVKF-IGDSL 853
I E+S +GT I +IK D D G N M T + + + F ++ + K I +L
Sbjct: 352 IPEDSDLGTVIA---LIKVRDKDSGQNG--MVTCYTQEEVPFKLESTSKNYYKLVIAGAL 406
Query: 854 DREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEFNQ 895
+RE+ Y ++++A D G LSS + + I D NDN P F+Q
Sbjct: 407 NREQTADYNVTIIATDKGKPALSSRTSITLHISDINDNAPVFHQ 450
Score = 59.7 bits (138), Expect = 8e-08
Identities = 38/126 (30%), Positives = 62/126 (49%), Gaps = 8/126 (6%)
Query: 218 IHAIDQDLGVGATLRYELISGN-DRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQV 276
+ A DQD G+ A + Y ++ LF+L+ G + LD + + + +VL V
Sbjct: 261 VMATDQDEGINAEITYAFLNSPISTSLFNLNPNTGDITTNGTLDFE-----ETSRYVLSV 315
Query: 277 QASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQG 336
+A + + TA V+IE++D NDN PE ++ I E+ G + + DKD G
Sbjct: 316 EAK--DGGVHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDSDLGTVIALIKVRDKDSG 373
Query: 337 ENGEFT 342
+NG T
Sbjct: 374 QNGMVT 379
Score = 56.8 bits (131), Expect = 6e-07
Identities = 59/199 (29%), Positives = 90/199 (45%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN P G +I +++A D D G N ++ Y + P LS Y ++ + G
Sbjct: 457 VSENNPPGASIAQVSASDPDLGPNDRVSYSILASDLEPRELLS--------YVSVSPQSG 508
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFP--VFKKTWYNFN 1053
V R+ E F L + A D G+ L+ N+S+RV V D+ND+ P ++ + +
Sbjct: 509 VVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGS 568
Query: 1054 -----VEEAQYTRRVLGKVDATDADFGQNANLTYFI-QPSDTDLPFEISPLTGVLSVNGE 1107
V A ++ KV A DAD G NA L+Y + Q S+ L F + TG +
Sbjct: 569 ALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGL-FSLGLRTGEVRTARA 627
Query: 1108 LDRETEDKYILTVVARDNG 1126
L + L V RD G
Sbjct: 628 LGDRDAARQRLLVAVRDGG 646
Score = 56.4 bits (130), Expect = 7e-07
Identities = 70/335 (20%), Positives = 133/335 (39%), Gaps = 27/335 (8%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L + G +S + + + D NDN P+F Y V++ E P G +
Sbjct: 209 LTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDE 268
Query: 127 SLTIPLTV-----PRGLTIFK-DIRAFDRDKPNTPNSDVHYSIVSGNDDGHFALESSHKP 180
+ +T P ++F + D T + + V + + ++H
Sbjct: 269 GINAEITYAFLNSPISTSLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGVHTAHCN 328
Query: 181 VLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI---DQDLGVGATLRYELIS 237
V ++ D D ++ M+ +I ++ I I D+D G +
Sbjct: 329 V----QIEIVDENDNAPEVTFMSFSNQIPEDSDLGTVIALIKVRDKDSGQNGMVTCYT-- 382
Query: 238 GNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELL 297
+ F L+S + + + K + A + Q + + + A+ P +++ + + +
Sbjct: 383 -QEEVPFKLESTSKNYY--KLVIAGALNREQTADYNVTIIATDKGKPALSSRTSITLHIS 439
Query: 298 DLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL---D-DPK---G 350
D+NDN P F Y + + EN P G S+ QV A+D D G N +Y + D +P+
Sbjct: 440 DINDNAPVFHQASYVVHVSENNPPGASIAQVSASDPDLGPNDRVSYSILASDLEPRELLS 499
Query: 351 AFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
S+ P+SG V Q D E + + + A++
Sbjct: 500 YVSVSPQSG--VVFAQRAFDHEQLRAFELTLQARD 532
Score = 48.8 bits (111), Expect = 1e-04
Identities = 50/172 (29%), Positives = 81/172 (47%), Gaps = 24/172 (13%)
Query: 218 IHAIDQDLGVGATLRYELISGN--DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTF 272
+ A D DLG + Y +++ + R+L S SV+ G +F ++ D + Q F
Sbjct: 470 VSASDPDLGPNDRVSYSILASDLEPRELLSYVSVSPQSGVVFAQRAFDHE-----QLRAF 524
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLPN----GFSV 325
L +QA +P +A + + + DLNDN P + ++ + +P G+ V
Sbjct: 525 ELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLV 584
Query: 326 LQVMATDKDQGENGEFTY---QLDDPKGAFSIDPRSGWLTVRNQTVL-DREA 373
+V+A D D G N +Y Q +P G FS+ R+G VR L DR+A
Sbjct: 585 TKVVAVDADSGHNAWLSYHVLQASEP-GLFSLGLRTG--EVRTARALGDRDA 633
Score = 39.1 bits (87), Expect = 0.12
Identities = 47/190 (24%), Positives = 71/190 (37%), Gaps = 14/190 (7%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT- 1089
V V ++D+ND+ P F + + E+ A DAD N+ Y I P+
Sbjct: 116 VVVVIQDINDNAPRFVAKGIDLEICESALPGVKFSLDSAQDADVEGNSLKLYTINPNQYF 175
Query: 1090 DLPFEISPLTG---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
L + SP VL + LDRE + + L + A D G D ND
Sbjct: 176 SLSTKESPDGSKYPVLLLEKPLDREHQSSHRLILTAMDGG-DPPLSGTTHIWIRVTDAND 234
Query: 1147 NSPKF------YAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVF 1200
N+P F + E + W ++ E + Y N+PI T++ +
Sbjct: 235 NAPVFSQEVYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFL---NSPISTSLFNLN 291
Query: 1201 ANDTDFIGNG 1210
N D NG
Sbjct: 292 PNTGDITTNG 301
>BC101805-1|AAI01806.1| 811|Homo sapiens protocadherin gamma
subfamily B, 2 protein.
Length = 811
Score = 101 bits (243), Expect = 2e-20
Identities = 117/474 (24%), Positives = 202/474 (42%), Gaps = 43/474 (9%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E ++ + V + D NDN P+F + + + + K GT A+D D+G N +
Sbjct: 111 ENPLNIFYIAVIVQDINDNTPLFKQTKI-NLKIGESTKPGTTFPLDPALDSDVGPNSLQR 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVT 556
Y L + + + + + H+L + +
Sbjct: 170 YHLNDNEYFDLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIR 229
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGY 614
I+VT + P P F Y + +V G V Q+ D E +++Y H
Sbjct: 230 IKVT--DANDNP--PVFSQDVYRVTLREDVPPGFFVLQVTATDRDEGINAEITYS-FHNV 284
Query: 615 EEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVND- 671
+E V F + E++G IT DDL Y ++ ++ +L+ + V ++D ND
Sbjct: 285 DEQVKHFFNLNEKTGEITTKDDLDFEIASSYTL-SIEAKDPGDLAAHCSIQVEILDDNDC 343
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSS-----IYGNGTGNVRFLIANQQDV 726
V++ +P+ +++ G I I + S +Y GN +F++ +
Sbjct: 344 APEVIVTSVSTPL---PEDSPPGTVIALIKTRDRDSGENGEVYCQVLGNAKFILKSSS-- 398
Query: 727 TDDIAIAEDGTIFTQKPLDREKRDVYRMTVIA-EFNKGVISGAGIYQVTIYIEDENDNPP 785
+ + DG LDRE+ Y +T+ A + K +S + I VT++I D NDN P
Sbjct: 399 KNYYKLVTDGA------LDREEIPEYNLTITATDGGKPPLSSSII--VTLHISDVNDNAP 450
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEMF---DV 839
VF+ +Y + EN+ G I I A+D D G + Y++ + +E+ V
Sbjct: 451 VFQQTSYMVHVAENNPPGASIAQ---ISASDPDLGPSGQVSYSIVASDLKPREILSYVSV 507
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
+GVV F + D E+ ++L+L ARD G LS+ L +++GD NDN P
Sbjct: 508 SAQSGVV-FAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAP 560
Score = 83.8 bits (198), Expect = 4e-15
Identities = 59/177 (33%), Positives = 95/177 (53%), Gaps = 21/177 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSL---DSVNG----SLFLEKELDLDAEHNLQANTF 272
A+D D+G + RY L ND + F L + +G L L+ LD + EH+L
Sbjct: 157 ALDSDVGPNSLQRYHL---NDNEYFDLAEKQTPDGRKYPELILKHSLDRE-EHSLHQ--- 209
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
L + A +P ++ ++ I++ D NDN P F D Y +++ E++P GF VLQV ATD
Sbjct: 210 -LVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVYRVTLREDVPPGFFVLQVTATD 268
Query: 333 KDQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+D+G N E TY + K F+++ ++G +T ++ LD E SS + + AK+
Sbjct: 269 RDEGINAEITYSFHNVDEQVKHFFNLNEKTGEITTKDD--LDFEIASSYTLSIEAKD 323
Score = 79.0 bits (186), Expect = 1e-13
Identities = 51/152 (33%), Positives = 78/152 (51%), Gaps = 8/152 (5%)
Query: 744 LDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIG 803
LDRE+ ++++ V+ + G +G Q+ I + D NDNPPVF Y + E+ G
Sbjct: 200 LDREEHSLHQL-VLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVYRVTLREDVPPG 258
Query: 804 TEIKMDNIIKATDADEGTNALFMYTLFG---EGKEMFDVDENTGVVKFIGDSLDREKKIM 860
+ + ATD DEG NA Y+ + K F+++E TG + D LD E
Sbjct: 259 FFVLQ---VTATDRDEGINAEITYSFHNVDEQVKHFFNLNEKTGEIT-TKDDLDFEIASS 314
Query: 861 YKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
Y LS+ A+D G L++ + + I D+ND PE
Sbjct: 315 YTLSIEAKDPGDLAAHCSIQVEILDDNDCAPE 346
Score = 78.6 bits (185), Expect = 2e-13
Identities = 65/239 (27%), Positives = 108/239 (45%), Gaps = 19/239 (7%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+E+ N A +V +PE+ P GT I + D DSG NG++ + +
Sbjct: 335 VEILDDNDCAPEVIVTSVSTPLPEDSPPGTVIALIKTRDRDSGENGEVYCQV-----LGN 389
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVK 1036
+K + Y ++ + + +P E+ L I+A DGG L+ +I V + +
Sbjct: 390 AKFILKSSSKNYYKLVTDG---ALDREEIP---EYNLTITATDGGKPPLSSSIIVTLHIS 443
Query: 1037 DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTD----LP 1092
DVND+ PVF++T Y +V E + ++ A+D D G + ++Y I SD L
Sbjct: 444 DVNDNAPVFQQTSYMVHVAENNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREILS 503
Query: 1093 F-EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
+ +S +GV+ D E + LT+ ARD G D+NDN+P+
Sbjct: 504 YVSVSAQSGVVFAQRAFDHEQLRAFELTLQARDQG-SPALSANVSLRVLVGDLNDNAPR 561
Score = 74.9 bits (176), Expect = 2e-12
Identities = 60/212 (28%), Positives = 95/212 (44%), Gaps = 14/212 (6%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
E++P G ++++ A D D G+N +I Y F++ D +VK +F +NE+ G +
Sbjct: 253 EDVPPGFFVLQVTATDRDEGINAEITYSFHN----------VDE-QVKHFFNLNEKTGEI 301
Query: 1002 IVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQY 1059
L E S + L+I A D G+L + S++V + D ND P T + + E
Sbjct: 302 TTKDDLDFEIASSYTLSIEAKDPGDLAAHCSIQVEILDDNDCAPEVIVTSVSTPLPEDSP 361
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
V+ + D D G+N + + + + S L +G LDRE +Y LT
Sbjct: 362 PGTVIALIKTRDRDSGENGEVYCQVLGNAKFILKSSSKNYYKLVTDGALDREEIPEYNLT 421
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
+ A D G DVNDN+P F
Sbjct: 422 ITATDGG-KPPLSSSIIVTLHISDVNDNAPVF 452
Score = 68.9 bits (161), Expect = 1e-10
Identities = 59/194 (30%), Positives = 88/194 (45%), Gaps = 17/194 (8%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP-PSKLSADALEVKRYFVINERH 998
I E+ GTT ALD D G N RY N Y K + D ++
Sbjct: 142 IGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYFDLAEKQTPDG----------RKY 191
Query: 999 GHVIVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNV 1054
+I+ SL E S +L ++A+DGG+ + +R+ V D ND+ PVF + Y +
Sbjct: 192 PELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVYRVTL 251
Query: 1055 EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP--FEISPLTGVLSVNGELDRET 1112
E + +V ATD D G NA +TY D + F ++ TG ++ +LD E
Sbjct: 252 REDVPPGFFVLQVTATDRDEGINAEITYSFHNVDEQVKHFFNLNEKTGEITTKDDLDFEI 311
Query: 1113 EDKYILTVVARDNG 1126
Y L++ A+D G
Sbjct: 312 ASSYTLSIEAKDPG 325
Score = 66.1 bits (154), Expect = 9e-10
Identities = 50/170 (29%), Positives = 80/170 (47%), Gaps = 13/170 (7%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
E G + +DRE+ + + +F+ + I+ + + ++D NDN P+F+
Sbjct: 80 ESGDLLVSDRIDREQICGKQPLCVLDFDTVAENPLNIFYIAVIVQDINDNTPLFKQTKIN 139
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDV------DENTGVVK 847
I E++K GT +D A D+D G N+L Y L E FD+ D
Sbjct: 140 LKIGESTKPGTTFPLD---PALDSDVGPNSLQRYHL--NDNEYFDLAEKQTPDGRKYPEL 194
Query: 848 FIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+ SLDRE+ +++L L A D G S ++ I + D NDN P F+Q
Sbjct: 195 ILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQ 244
Score = 62.1 bits (144), Expect = 1e-08
Identities = 66/282 (23%), Positives = 122/282 (43%), Gaps = 33/282 (11%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF- 141
+ V ++D+NDN P+F T ++ + E T G P+ P+L + P L +
Sbjct: 119 IAVIVQDINDNTPLFKQTKINLKIGESTKPGTTF------PLDPALDSDVG-PNSLQRYH 171
Query: 142 -KDIRAFDRDKPNTPNSDVHYSIV---SGNDDGHF-------ALESSHKP----VLLLRK 186
D FD + TP+ + ++ S + + H A++ P + K
Sbjct: 172 LNDNEYFDLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIK 231
Query: 187 VLDYDAGDKEF-QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND--RKL 243
V D + F Q V + + F + A D+D G+ A + Y + ++ +
Sbjct: 232 VTDANDNPPVFSQDVYRVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHNVDEQVKHF 291
Query: 244 FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNL 303
F+L+ G + + +LD + A+++ L ++A + A +++E+LD ND
Sbjct: 292 FNLNEKTGEITTKDDLDFEI-----ASSYTLSIEAKDPGD--LAAHCSIQVEILDDNDCA 344
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
PE V + + E+ P G + + D+D GENGE Q+
Sbjct: 345 PEVIVTSVSTPLPEDSPPGTVIALIKTRDRDSGENGEVYCQV 386
Score = 59.3 bits (137), Expect = 1e-07
Identities = 60/199 (30%), Positives = 91/199 (45%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN P G +I +++A D D G +GQ+ Y + P LS Y ++ + G
Sbjct: 461 VAENNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREILS--------YVSVSAQSG 512
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFP--VFKKTWYNFN 1053
V R+ E F L + A D G+ L+ N+S+RV V D+ND+ P ++ + +
Sbjct: 513 VVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGS 572
Query: 1054 -----VEEAQYTRRVLGKVDATDADFGQNANLTYFI-QPSDTDLPFEISPLTGVLSVNGE 1107
V A ++ KV A DAD G NA L+Y + Q S+ L F + TG +
Sbjct: 573 ALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGL-FSLGLRTGEVRTARA 631
Query: 1108 LDRETEDKYILTVVARDNG 1126
L + L V RD G
Sbjct: 632 LGDRDAARQRLLVAVRDGG 650
Score = 58.8 bits (136), Expect = 1e-07
Identities = 64/288 (22%), Positives = 117/288 (40%), Gaps = 17/288 (5%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L + G S + + + D NDN P+F Y VT+ E P G F+ +
Sbjct: 212 LTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVYRVTLREDVPPG--FFVLQVTATDR 269
Query: 127 SLTIPLTVPRGL-TIFKDIRAF----DRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
I + + + ++ F ++ T D+ + I S A +
Sbjct: 270 DEGINAEITYSFHNVDEQVKHFFNLNEKTGEITTKDDLDFEIASSYTLSIEAKDPGDLAA 329
Query: 182 LLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGATLRYELIS 237
+V D D ++++ + + ++ P + A+ D+D G + Y +
Sbjct: 330 HCSIQVEILDDNDCAPEVIVTSVSTPLPEDSP-PGTVIALIKTRDRDSGENGEV-YCQVL 387
Query: 238 GNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELL 297
GN + + S N L + LD E + N L + A+ P ++ V + +
Sbjct: 388 GNAKFILKSSSKN-YYKLVTDGALDREEIPEYN---LTITATDGGKPPLSSSIIVTLHIS 443
Query: 298 DLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
D+NDN P F+ Y + + EN P G S+ Q+ A+D D G +G+ +Y +
Sbjct: 444 DVNDNAPVFQQTSYMVHVAENNPPGASIAQISASDPDLGPSGQVSYSI 491
Score = 53.6 bits (123), Expect = 5e-06
Identities = 51/163 (31%), Positives = 74/163 (45%), Gaps = 10/163 (6%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I T+ LD E Y +++ A+ + G ++ QV I D+ND P +
Sbjct: 299 GEITTKDDLDFEIASSYTLSIEAK-DPGDLAAHCSIQVEIL--DDNDCAPEVIVTSVSTP 355
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD-SLD 854
+ E+S GT I + IK D D G N + G K + + K + D +LD
Sbjct: 356 LPEDSPPGTVIAL---IKTRDRDSGENGEVYCQVLGNAKFILK-SSSKNYYKLVTDGALD 411
Query: 855 REKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
RE+ Y L++ A D G LSS + + I D NDN P F Q
Sbjct: 412 REEIPEYNLTITATDGGKPPLSSSIIVTLHISDVNDNAPVFQQ 454
Score = 53.2 bits (122), Expect = 7e-06
Identities = 49/185 (26%), Positives = 77/185 (41%), Gaps = 12/185 (6%)
Query: 976 IPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEF-RLNISALDGGNLNDN----IS 1030
+P KL A K YF +N G ++V+ + E + + LD + +N
Sbjct: 61 LPARKLRVSA--EKEYFTVNPESGDLLVSDRIDREQICGKQPLCVLDFDTVAENPLNIFY 118
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD-T 1089
+ V V+D+ND+ P+FK+T N + E+ A D+D G N+ Y + ++
Sbjct: 119 IAVIVQDINDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYF 178
Query: 1090 DLPFEISP---LTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
DL + +P L + LDRE + L + A D G D ND
Sbjct: 179 DLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGG-DPPQSGTTQIRIKVTDAND 237
Query: 1147 NSPKF 1151
N P F
Sbjct: 238 NPPVF 242
Score = 49.6 bits (113), Expect = 8e-05
Identities = 50/172 (29%), Positives = 81/172 (47%), Gaps = 24/172 (13%)
Query: 218 IHAIDQDLGVGATLRYELISGN--DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTF 272
I A D DLG + Y +++ + R++ S SV+ G +F ++ D + Q F
Sbjct: 474 ISASDPDLGPSGQVSYSIVASDLKPREILSYVSVSAQSGVVFAQRAFDHE-----QLRAF 528
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLPN----GFSV 325
L +QA +P +A + + + DLNDN P + ++ + +P G+ V
Sbjct: 529 ELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLV 588
Query: 326 LQVMATDKDQGENGEFTY---QLDDPKGAFSIDPRSGWLTVRNQTVL-DREA 373
+V+A D D G N +Y Q +P G FS+ R+G VR L DR+A
Sbjct: 589 TKVVAVDADSGHNAWLSYHVLQASEP-GLFSLGLRTG--EVRTARALGDRDA 637
Score = 45.6 bits (103), Expect = 0.001
Identities = 61/246 (24%), Positives = 106/246 (43%), Gaps = 13/246 (5%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L S + V + + D NDN PVF ++ Y + N G I ++ A DPDLG +G V Y
Sbjct: 432 LSSSIIVTLHISDVNDNAPVFQQTS-YMVHVAENNPPGASIAQISASDPDLGPSGQVSYS 490
Query: 499 LQRT--SNLTITSPFKINPNTGTVSVAESPILEGRHA--LFVEASDQPANPSERRYSLAV 554
+ + I S ++ +G V + E A L ++A DQ + SL V
Sbjct: 491 IVASDLKPREILSYVSVSAQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRV 550
Query: 555 VTIEVT-RGTKGNKPDI-PDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND--VSYDL 610
+ ++ + P + PD G+ V G V ++ DA ++ +SY +
Sbjct: 551 LVGDLNDNAPRVLYPALGPD--GSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHV 608
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L E G+ F++ R+G + L + VA+++ + AT+H++ +
Sbjct: 609 LQASEPGL-FSLGLRTGEVRTARALGDRDAARQRL-LVAVRDGGQPPLSATATLHLIFAD 666
Query: 671 DERGVL 676
+ VL
Sbjct: 667 SLQEVL 672
Score = 39.1 bits (87), Expect = 0.12
Identities = 42/172 (24%), Positives = 72/172 (41%), Gaps = 10/172 (5%)
Query: 429 TENIEYYDE-QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDP 487
T +IE D L + +++V +LD ND P + +++ + ++ GTVI +K D
Sbjct: 316 TLSIEAKDPGDLAAHCSIQVEILDDNDCAPEVIVTSV-STPLPEDSPPGTVIALIKTRDR 374
Query: 488 DLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSE 547
D G+NG V + + + S K T + + + L + A+D P
Sbjct: 375 DSGENGEVYCQVLGNAKFILKSSSKNYYKLVTDGALDREEIP-EYNLTITATDGGKPPLS 433
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND 599
S +VT+ ++ + P F Y V N G S+ QI +D
Sbjct: 434 ---SSIIVTLHIS----DVNDNAPVFQQTSYMVHVAENNPPGASIAQISASD 478
Score = 35.1 bits (77), Expect = 2.0
Identities = 29/108 (26%), Positives = 48/108 (44%), Gaps = 4/108 (3%)
Query: 240 DRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
+++ F+++ +G L + +D + Q VL + NPL V ++ D+
Sbjct: 71 EKEYFTVNPESGDLLVSDRIDREQICGKQP-LCVLDFD-TVAENPLNIFYIAVIVQ--DI 126
Query: 300 NDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD 347
NDN P F+ N+ I E+ G + A D D G N Y L+D
Sbjct: 127 NDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLND 174
>AF152518-1|AAD43778.1| 811|Homo sapiens protocadherin gamma B2
short form protein protein.
Length = 811
Score = 101 bits (243), Expect = 2e-20
Identities = 117/474 (24%), Positives = 202/474 (42%), Gaps = 43/474 (9%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E ++ + V + D NDN P+F + + + + K GT A+D D+G N +
Sbjct: 111 ENPLNIFYIAVIVQDINDNTPLFKQTKI-NLKIGESTKPGTTFPLDPALDSDVGPNSLQR 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVT 556
Y L + + + + + H+L + +
Sbjct: 170 YHLNDNEYFDLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIR 229
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGY 614
I+VT + P P F Y + +V G V Q+ D E +++Y H
Sbjct: 230 IKVT--DANDNP--PVFSQDVYRVTLREDVPPGFFVLQVTATDRDEGINAEITYS-FHNV 284
Query: 615 EEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVND- 671
+E V F + E++G IT DDL Y ++ ++ +L+ + V ++D ND
Sbjct: 285 DEQVKHFFNLNEKTGEITTKDDLDFEIASSYTL-SIEAKDPGDLAAHCSIQVEILDDNDC 343
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSS-----IYGNGTGNVRFLIANQQDV 726
V++ +P+ +++ G I I + S +Y GN +F++ +
Sbjct: 344 APEVIVTSVSTPL---PEDSPPGTVIALIKTRDRDSGENGEVYCQVLGNAKFILKSSS-- 398
Query: 727 TDDIAIAEDGTIFTQKPLDREKRDVYRMTVIA-EFNKGVISGAGIYQVTIYIEDENDNPP 785
+ + DG LDRE+ Y +T+ A + K +S + I VT++I D NDN P
Sbjct: 399 KNYYKLVTDGA------LDREEIPEYNLTITATDGGKPPLSSSII--VTLHISDVNDNAP 450
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEMF---DV 839
VF+ +Y + EN+ G I I A+D D G + Y++ + +E+ V
Sbjct: 451 VFQQTSYMVHVAENNPPGASIAQ---ISASDPDLGPSGQVSYSIVASDLKPREILSYVSV 507
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
+GVV F + D E+ ++L+L ARD G LS+ L +++GD NDN P
Sbjct: 508 SAQSGVV-FAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAP 560
Score = 83.8 bits (198), Expect = 4e-15
Identities = 59/177 (33%), Positives = 95/177 (53%), Gaps = 21/177 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSL---DSVNG----SLFLEKELDLDAEHNLQANTF 272
A+D D+G + RY L ND + F L + +G L L+ LD + EH+L
Sbjct: 157 ALDSDVGPNSLQRYHL---NDNEYFDLAEKQTPDGRKYPELILKHSLDRE-EHSLHQ--- 209
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
L + A +P ++ ++ I++ D NDN P F D Y +++ E++P GF VLQV ATD
Sbjct: 210 -LVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVYRVTLREDVPPGFFVLQVTATD 268
Query: 333 KDQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+D+G N E TY + K F+++ ++G +T ++ LD E SS + + AK+
Sbjct: 269 RDEGINAEITYSFHNVDEQVKHFFNLNEKTGEITTKDD--LDFEIASSYTLSIEAKD 323
Score = 79.0 bits (186), Expect = 1e-13
Identities = 51/152 (33%), Positives = 78/152 (51%), Gaps = 8/152 (5%)
Query: 744 LDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIG 803
LDRE+ ++++ V+ + G +G Q+ I + D NDNPPVF Y + E+ G
Sbjct: 200 LDREEHSLHQL-VLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVYRVTLREDVPPG 258
Query: 804 TEIKMDNIIKATDADEGTNALFMYTLFG---EGKEMFDVDENTGVVKFIGDSLDREKKIM 860
+ + ATD DEG NA Y+ + K F+++E TG + D LD E
Sbjct: 259 FFVLQ---VTATDRDEGINAEITYSFHNVDEQVKHFFNLNEKTGEIT-TKDDLDFEIASS 314
Query: 861 YKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
Y LS+ A+D G L++ + + I D+ND PE
Sbjct: 315 YTLSIEAKDPGDLAAHCSIQVEILDDNDCAPE 346
Score = 78.6 bits (185), Expect = 2e-13
Identities = 65/239 (27%), Positives = 108/239 (45%), Gaps = 19/239 (7%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+E+ N A +V +PE+ P GT I + D DSG NG++ + +
Sbjct: 335 VEILDDNDCAPEVIVTSVSTPLPEDSPPGTVIALIKTRDRDSGENGEVYCQV-----LGN 389
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVK 1036
+K + Y ++ + + +P E+ L I+A DGG L+ +I V + +
Sbjct: 390 AKFILKSSSKNYYKLVTDG---ALDREEIP---EYNLTITATDGGKPPLSSSIIVTLHIS 443
Query: 1037 DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTD----LP 1092
DVND+ PVF++T Y +V E + ++ A+D D G + ++Y I SD L
Sbjct: 444 DVNDNAPVFQQTSYMVHVAENNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREILS 503
Query: 1093 F-EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
+ +S +GV+ D E + LT+ ARD G D+NDN+P+
Sbjct: 504 YVSVSAQSGVVFAQRAFDHEQLRAFELTLQARDQG-SPALSANVSLRVLVGDLNDNAPR 561
Score = 74.9 bits (176), Expect = 2e-12
Identities = 60/212 (28%), Positives = 95/212 (44%), Gaps = 14/212 (6%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
E++P G ++++ A D D G+N +I Y F++ D +VK +F +NE+ G +
Sbjct: 253 EDVPPGFFVLQVTATDRDEGINAEITYSFHN----------VDE-QVKHFFNLNEKTGEI 301
Query: 1002 IVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQY 1059
L E S + L+I A D G+L + S++V + D ND P T + + E
Sbjct: 302 TTKDDLDFEIASSYTLSIEAKDPGDLAAHCSIQVEILDDNDCAPEVIVTSVSTPLPEDSP 361
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
V+ + D D G+N + + + + S L +G LDRE +Y LT
Sbjct: 362 PGTVIALIKTRDRDSGENGEVYCQVLGNAKFILKSSSKNYYKLVTDGALDREEIPEYNLT 421
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
+ A D G DVNDN+P F
Sbjct: 422 ITATDGG-KPPLSSSIIVTLHISDVNDNAPVF 452
Score = 68.9 bits (161), Expect = 1e-10
Identities = 59/194 (30%), Positives = 88/194 (45%), Gaps = 17/194 (8%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP-PSKLSADALEVKRYFVINERH 998
I E+ GTT ALD D G N RY N Y K + D ++
Sbjct: 142 IGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYFDLAEKQTPDG----------RKY 191
Query: 999 GHVIVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNV 1054
+I+ SL E S +L ++A+DGG+ + +R+ V D ND+ PVF + Y +
Sbjct: 192 PELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVYRVTL 251
Query: 1055 EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP--FEISPLTGVLSVNGELDRET 1112
E + +V ATD D G NA +TY D + F ++ TG ++ +LD E
Sbjct: 252 REDVPPGFFVLQVTATDRDEGINAEITYSFHNVDEQVKHFFNLNEKTGEITTKDDLDFEI 311
Query: 1113 EDKYILTVVARDNG 1126
Y L++ A+D G
Sbjct: 312 ASSYTLSIEAKDPG 325
Score = 66.1 bits (154), Expect = 9e-10
Identities = 50/170 (29%), Positives = 80/170 (47%), Gaps = 13/170 (7%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
E G + +DRE+ + + +F+ + I+ + + ++D NDN P+F+
Sbjct: 80 ESGDLLVSDRIDREQICGKQPLCVLDFDTVAENPLNIFYIAVIVQDINDNTPLFKQTKIN 139
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDV------DENTGVVK 847
I E++K GT +D A D+D G N+L Y L E FD+ D
Sbjct: 140 LKIGESTKPGTTFPLD---PALDSDVGPNSLQRYHL--NDNEYFDLAEKQTPDGRKYPEL 194
Query: 848 FIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+ SLDRE+ +++L L A D G S ++ I + D NDN P F+Q
Sbjct: 195 ILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQ 244
Score = 62.1 bits (144), Expect = 1e-08
Identities = 66/282 (23%), Positives = 122/282 (43%), Gaps = 33/282 (11%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF- 141
+ V ++D+NDN P+F T ++ + E T G P+ P+L + P L +
Sbjct: 119 IAVIVQDINDNTPLFKQTKINLKIGESTKPGTTF------PLDPALDSDVG-PNSLQRYH 171
Query: 142 -KDIRAFDRDKPNTPNSDVHYSIV---SGNDDGHF-------ALESSHKP----VLLLRK 186
D FD + TP+ + ++ S + + H A++ P + K
Sbjct: 172 LNDNEYFDLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIK 231
Query: 187 VLDYDAGDKEF-QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND--RKL 243
V D + F Q V + + F + A D+D G+ A + Y + ++ +
Sbjct: 232 VTDANDNPPVFSQDVYRVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHNVDEQVKHF 291
Query: 244 FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNL 303
F+L+ G + + +LD + A+++ L ++A + A +++E+LD ND
Sbjct: 292 FNLNEKTGEITTKDDLDFEI-----ASSYTLSIEAKDPGD--LAAHCSIQVEILDDNDCA 344
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
PE V + + E+ P G + + D+D GENGE Q+
Sbjct: 345 PEVIVTSVSTPLPEDSPPGTVIALIKTRDRDSGENGEVYCQV 386
Score = 59.3 bits (137), Expect = 1e-07
Identities = 60/199 (30%), Positives = 91/199 (45%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN P G +I +++A D D G +GQ+ Y + P LS Y ++ + G
Sbjct: 461 VAENNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREILS--------YVSVSAQSG 512
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFP--VFKKTWYNFN 1053
V R+ E F L + A D G+ L+ N+S+RV V D+ND+ P ++ + +
Sbjct: 513 VVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGS 572
Query: 1054 -----VEEAQYTRRVLGKVDATDADFGQNANLTYFI-QPSDTDLPFEISPLTGVLSVNGE 1107
V A ++ KV A DAD G NA L+Y + Q S+ L F + TG +
Sbjct: 573 ALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGL-FSLGLRTGEVRTARA 631
Query: 1108 LDRETEDKYILTVVARDNG 1126
L + L V RD G
Sbjct: 632 LGDRDAARQRLLVAVRDGG 650
Score = 58.8 bits (136), Expect = 1e-07
Identities = 64/288 (22%), Positives = 117/288 (40%), Gaps = 17/288 (5%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L + G S + + + D NDN P+F Y VT+ E P G F+ +
Sbjct: 212 LTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVYRVTLREDVPPG--FFVLQVTATDR 269
Query: 127 SLTIPLTVPRGL-TIFKDIRAF----DRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
I + + + ++ F ++ T D+ + I S A +
Sbjct: 270 DEGINAEITYSFHNVDEQVKHFFNLNEKTGEITTKDDLDFEIASSYTLSIEAKDPGDLAA 329
Query: 182 LLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGATLRYELIS 237
+V D D ++++ + + ++ P + A+ D+D G + Y +
Sbjct: 330 HCSIQVEILDDNDCAPEVIVTSVSTPLPEDSP-PGTVIALIKTRDRDSGENGEV-YCQVL 387
Query: 238 GNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELL 297
GN + + S N L + LD E + N L + A+ P ++ V + +
Sbjct: 388 GNAKFILKSSSKN-YYKLVTDGALDREEIPEYN---LTITATDGGKPPLSSSIIVTLHIS 443
Query: 298 DLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
D+NDN P F+ Y + + EN P G S+ Q+ A+D D G +G+ +Y +
Sbjct: 444 DVNDNAPVFQQTSYMVHVAENNPPGASIAQISASDPDLGPSGQVSYSI 491
Score = 53.6 bits (123), Expect = 5e-06
Identities = 51/163 (31%), Positives = 74/163 (45%), Gaps = 10/163 (6%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I T+ LD E Y +++ A+ + G ++ QV I D+ND P +
Sbjct: 299 GEITTKDDLDFEIASSYTLSIEAK-DPGDLAAHCSIQVEIL--DDNDCAPEVIVTSVSTP 355
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD-SLD 854
+ E+S GT I + IK D D G N + G K + + K + D +LD
Sbjct: 356 LPEDSPPGTVIAL---IKTRDRDSGENGEVYCQVLGNAKFILK-SSSKNYYKLVTDGALD 411
Query: 855 REKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
RE+ Y L++ A D G LSS + + I D NDN P F Q
Sbjct: 412 REEIPEYNLTITATDGGKPPLSSSIIVTLHISDVNDNAPVFQQ 454
Score = 53.2 bits (122), Expect = 7e-06
Identities = 49/185 (26%), Positives = 77/185 (41%), Gaps = 12/185 (6%)
Query: 976 IPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEF-RLNISALDGGNLNDN----IS 1030
+P KL A K YF +N G ++V+ + E + + LD + +N
Sbjct: 61 LPARKLRVSA--EKEYFTVNPESGDLLVSDRIDREQICGKQPLCVLDFDTVAENPLNIFY 118
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD-T 1089
+ V V+D+ND+ P+FK+T N + E+ A D+D G N+ Y + ++
Sbjct: 119 IAVIVQDINDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYF 178
Query: 1090 DLPFEISP---LTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
DL + +P L + LDRE + L + A D G D ND
Sbjct: 179 DLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGG-DPPQSGTTQIRIKVTDAND 237
Query: 1147 NSPKF 1151
N P F
Sbjct: 238 NPPVF 242
Score = 49.6 bits (113), Expect = 8e-05
Identities = 50/172 (29%), Positives = 81/172 (47%), Gaps = 24/172 (13%)
Query: 218 IHAIDQDLGVGATLRYELISGN--DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTF 272
I A D DLG + Y +++ + R++ S SV+ G +F ++ D + Q F
Sbjct: 474 ISASDPDLGPSGQVSYSIVASDLKPREILSYVSVSAQSGVVFAQRAFDHE-----QLRAF 528
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLPN----GFSV 325
L +QA +P +A + + + DLNDN P + ++ + +P G+ V
Sbjct: 529 ELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLV 588
Query: 326 LQVMATDKDQGENGEFTY---QLDDPKGAFSIDPRSGWLTVRNQTVL-DREA 373
+V+A D D G N +Y Q +P G FS+ R+G VR L DR+A
Sbjct: 589 TKVVAVDADSGHNAWLSYHVLQASEP-GLFSLGLRTG--EVRTARALGDRDA 637
Score = 45.6 bits (103), Expect = 0.001
Identities = 61/246 (24%), Positives = 106/246 (43%), Gaps = 13/246 (5%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L S + V + + D NDN PVF ++ Y + N G I ++ A DPDLG +G V Y
Sbjct: 432 LSSSIIVTLHISDVNDNAPVFQQTS-YMVHVAENNPPGASIAQISASDPDLGPSGQVSYS 490
Query: 499 LQRT--SNLTITSPFKINPNTGTVSVAESPILEGRHA--LFVEASDQPANPSERRYSLAV 554
+ + I S ++ +G V + E A L ++A DQ + SL V
Sbjct: 491 IVASDLKPREILSYVSVSAQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRV 550
Query: 555 VTIEVT-RGTKGNKPDI-PDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND--VSYDL 610
+ ++ + P + PD G+ V G V ++ DA ++ +SY +
Sbjct: 551 LVGDLNDNAPRVLYPALGPD--GSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHV 608
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L E G+ F++ R+G + L + VA+++ + AT+H++ +
Sbjct: 609 LQASEPGL-FSLGLRTGEVRTARALGDRDAARQRL-LVAVRDGGQPPLSATATLHLIFAD 666
Query: 671 DERGVL 676
+ VL
Sbjct: 667 SLQEVL 672
Score = 39.1 bits (87), Expect = 0.12
Identities = 42/172 (24%), Positives = 72/172 (41%), Gaps = 10/172 (5%)
Query: 429 TENIEYYDE-QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDP 487
T +IE D L + +++V +LD ND P + +++ + ++ GTVI +K D
Sbjct: 316 TLSIEAKDPGDLAAHCSIQVEILDDNDCAPEVIVTSV-STPLPEDSPPGTVIALIKTRDR 374
Query: 488 DLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSE 547
D G+NG V + + + S K T + + + L + A+D P
Sbjct: 375 DSGENGEVYCQVLGNAKFILKSSSKNYYKLVTDGALDREEIP-EYNLTITATDGGKPPLS 433
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND 599
S +VT+ ++ + P F Y V N G S+ QI +D
Sbjct: 434 ---SSIIVTLHIS----DVNDNAPVFQQTSYMVHVAENNPPGASIAQISASD 478
Score = 35.1 bits (77), Expect = 2.0
Identities = 29/108 (26%), Positives = 48/108 (44%), Gaps = 4/108 (3%)
Query: 240 DRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
+++ F+++ +G L + +D + Q VL + NPL V ++ D+
Sbjct: 71 EKEYFTVNPESGDLLVSDRIDREQICGKQP-LCVLDFD-TVAENPLNIFYIAVIVQ--DI 126
Query: 300 NDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD 347
NDN P F+ N+ I E+ G + A D D G N Y L+D
Sbjct: 127 NDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLND 174
>AF152513-1|AAD43773.1| 818|Homo sapiens protocadherin gamma A6
short form protein protein.
Length = 818
Score = 101 bits (243), Expect = 2e-20
Identities = 112/467 (23%), Positives = 194/467 (41%), Gaps = 27/467 (5%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E ++ VEV ++D NDN P F+ L E + NA + ++ DPD+G N +
Sbjct: 111 EDKLNLYPVEVEIVDINDNTPRFLKEEL-EVKILENAAPSSRFPLMEVYDPDVGMNSLQG 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVT 556
+ L S+ ++ + + V E + A++ R S+A +
Sbjct: 170 FKLSGNSHFSVDVQSEAHGPKYPELVLEGTLDREGEAVYRLVLTAMDGGDPVRSSVAQIL 229
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGY 614
+ V + P F Y V N+ +GT V + D E +V+Y +
Sbjct: 230 VTVL----DVNDNTPMFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFVKIT 285
Query: 615 EE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDER 673
E+ F + +G I+ +L + Y+ V ++ L + ++DVND
Sbjct: 286 EKISQIFCLNVLTGEISTSANLDYEDSSFYEL-GVEARDGPGLRDRAKVLITILDVNDNV 344
Query: 674 GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIA 733
++ + S I A+ Q+F + G V I + ++
Sbjct: 345 PEVVVTSGSRTIAESAPPGTVIALFQVFDRDSGL-----NGLVTCSIPRSLPFELEKSVG 399
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
+ T LDRE+ +Y +TV A +KG + +++ + D NDNPP F H++Y
Sbjct: 400 NYYRLVTNAALDREEVFLYNITVTAT-DKGTPPLSTETIISLNVADTNDNPPTFPHSSYS 458
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMY-----TLFGEGKEMF-DVDENTGVVK 847
+++EN+ G I + A D D NA Y TL G + ++ +TG++
Sbjct: 459 VYVLENNPRGASIFS---VNALDPDVDQNAQVSYSLAEDTLQGAPLSSYVSINSDTGIL- 514
Query: 848 FIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
+ S D E+ +L + A D+G LSS L + + D+NDN PE
Sbjct: 515 YALRSFDYEQLRDLQLWVTASDSGDPPLSSNVSLSLFVLDQNDNAPE 561
Score = 86.2 bits (204), Expect = 8e-16
Identities = 70/235 (29%), Positives = 103/235 (43%), Gaps = 27/235 (11%)
Query: 929 LDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LDV+ P+F +PEN+P+GT ++ + A D D G++G++ Y F K+
Sbjct: 233 LDVNDNTPMFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSF--------VKI 284
Query: 982 SADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVN 1039
+ ++ + F +N G + + +L E S + L + A DG L D V + + DVN
Sbjct: 285 TE---KISQIFCLNVLTGEISTSANLDYEDSSFYELGVEARDGPGLRDRAKVLITILDVN 341
Query: 1040 DHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLT 1099
D+ P T + + E+ V+ D D G N +T I S LPFE+
Sbjct: 342 DNVPEVVVTSGSRTIAESAPPGTVIALFQVFDRDSGLNGLVTCSIPRS---LPFELEKSV 398
Query: 1100 G---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
G L N LDRE Y +TV A D G D NDN P F
Sbjct: 399 GNYYRLVTNAALDREEVFLYNITVTATDKG-TPPLSTETIISLNVADTNDNPPTF 452
Score = 71.3 bits (167), Expect = 2e-11
Identities = 44/125 (35%), Positives = 72/125 (57%), Gaps = 7/125 (5%)
Query: 222 DQDLGVGATLRYELISGNDRKLFSLD---SVNGSLFLEKELDLDAEHNLQANTFVLQVQA 278
D D+G+ + ++L SGN FS+D +G + E L+ + +A + L + A
Sbjct: 159 DPDVGMNSLQGFKL-SGNSH--FSVDVQSEAHGPKYPELVLEGTLDREGEA-VYRLVLTA 214
Query: 279 SQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGEN 338
+P++++ A++ + +LD+NDN P F Y +S+ ENLP G VL V ATD+D+G +
Sbjct: 215 MDGGDPVRSSVAQILVTVLDVNDNTPMFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVH 274
Query: 339 GEFTY 343
GE TY
Sbjct: 275 GEVTY 279
Score = 68.9 bits (161), Expect = 1e-10
Identities = 51/167 (30%), Positives = 78/167 (46%), Gaps = 9/167 (5%)
Query: 735 DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEG 794
+G++ T +DRE+ + FN V +Y V + I D NDN P F E
Sbjct: 81 NGSLVTAGRIDREELCAQSPRCLVSFNILVEDKLNLYPVEVEIVDINDNTPRFLKEELEV 140
Query: 795 FIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----IG 850
I+EN+ + +++ D D G N+L + L G DV K+ +
Sbjct: 141 KILENAAPSSRFP---LMEVYDPDVGMNSLQGFKLSGNSHFSVDVQSEAHGPKYPELVLE 197
Query: 851 DSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+LDRE + +Y+L L A D G SS A++++ + D NDN P F Q
Sbjct: 198 GTLDREGEAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFTQ 244
Score = 65.3 bits (152), Expect = 2e-09
Identities = 78/300 (26%), Positives = 122/300 (40%), Gaps = 21/300 (7%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRG 137
S+ + V + DVNDN P+F Y V+V E P G + +T
Sbjct: 223 SSVAQILVTVLDVNDNTPMFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFV 282
Query: 138 LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHF---ALESSHKPVLLLR-KVLD--YD 191
K + F N ++ S +D F +E+ P L R KVL D
Sbjct: 283 KITEKISQIFCL---NVLTGEISTSANLDYEDSSFYELGVEARDGPGLRDRAKVLITILD 339
Query: 192 AGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKL-FSLDSVN 250
D ++V+ SG R E P + A+ Q + L + R L F L+
Sbjct: 340 VNDNVPEVVV-TSGSRTIAESAPPGTVIALFQVFDRDSGLNGLVTCSIPRSLPFELEKSV 398
Query: 251 GSLF-LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
G+ + L LD E N + V A+ P + + + + + D NDN P F
Sbjct: 399 GNYYRLVTNAALDREEVFLYN---ITVTATDKGTPPLSTETIISLNVADTNDNPPTFPHS 455
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQT 367
Y++ ++EN P G S+ V A D D +N + +Y L D +GA P S ++++ + T
Sbjct: 456 SYSVYVLENNPRGASIFSVNALDPDVDQNAQVSYSLAEDTLQGA----PLSSYVSINSDT 511
Score = 64.5 bits (150), Expect = 3e-09
Identities = 82/329 (24%), Positives = 141/329 (42%), Gaps = 24/329 (7%)
Query: 1010 ESEFRLNISALDGGN-LNDNIS-VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKV 1067
E+ +RL ++A+DGG+ + +++ + V V DVND+ P+F + Y +V E + V
Sbjct: 205 EAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFTQPVYRVSVPENLPVGTPVLAV 264
Query: 1068 DATDADFGQNANLTY-FIQPSD-TDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
ATD D G + +TY F++ ++ F ++ LTG +S + LD E Y L V ARD
Sbjct: 265 TATDQDEGVHGEVTYSFVKITEKISQIFCLNVLTGEISTSANLDYEDSSFYELGVEARDG 324
Query: 1126 GXXXXXXXXXXXXXXXXDVNDNSPKFYAFD---ELLEWKHPEADELSNHNFE-SVMMIPV 1181
DVNDN P+ + E P F+ + +
Sbjct: 325 ---PGLRDRAKVLITILDVNDNVPEVVVTSGSRTIAESAPPGTVIALFQVFDRDSGLNGL 381
Query: 1182 YKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILM 1239
+I + P + +V + T+ + + LY++ + G P LS+ I+
Sbjct: 382 VTCSIPRSLPFELEKSVGNYYRLVTNAALDREEVFLYNITVTATDK--GTPPLSTETIIS 439
Query: 1240 VTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEH--YENFKMRYYILNE 1297
+ VAD D + P F Y + + EN + S+N + +N ++ Y + +
Sbjct: 440 LNVADTND-----NPPTFPHSSYSVYVLENNPRGASIFSVNALDPDVDQNAQVSYSLAED 494
Query: 1298 --NDTDIRRTFVIDPRNGTLYLVRSPDRE 1324
+ I+ G LY +RS D E
Sbjct: 495 TLQGAPLSSYVSINSDTGILYALRSFDYE 523
Score = 59.3 bits (137), Expect = 1e-07
Identities = 63/197 (31%), Positives = 93/197 (47%), Gaps = 21/197 (10%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
EN P G +I +NALD D N Q+ Y +E + + LS+ Y IN G +
Sbjct: 463 ENNPRGASIFSVNALDPDVDQNAQVSYSL-AEDTLQGAPLSS-------YVSINSDTGIL 514
Query: 1002 IVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVF----KKTWYNFN 1053
RS E + +L ++A D G+ L+ N+S+ +FV D ND+ P T +
Sbjct: 515 YALRSFDYEQLRDLQLWVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTG 574
Query: 1054 VEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG-VLSVNGELD 1109
VE A + ++ KV A D D GQNA L+Y + + F + TG V + LD
Sbjct: 575 VELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLD 634
Query: 1110 RETEDKYILTVVARDNG 1126
R+ K L V +D+G
Sbjct: 635 RDAL-KQSLVVAVQDHG 650
Score = 55.2 bits (127), Expect = 2e-06
Identities = 61/232 (26%), Positives = 104/232 (44%), Gaps = 22/232 (9%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I T LD E Y + V A G+ A +V I I D NDN P +
Sbjct: 299 GEISTSANLDYEDSSFYELGVEARDGPGLRDRA---KVLITILDVNDNVPEVVVTSGSRT 355
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTG-VVKFIGDS-L 853
I E++ GT I + + D D G N L ++ F+++++ G + + ++ L
Sbjct: 356 IAESAPPGTVIALFQVF---DRDSGLNGLVTCSI--PRSLPFELEKSVGNYYRLVTNAAL 410
Query: 854 DREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
DRE+ +Y +++ A D G LS+E + + + D NDN P F + V E
Sbjct: 411 DREEVFLYNITVTATDKGTPPLSTETIISLNVADTNDNPPTFPHSSYSVYV---LENNPR 467
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPL-FLIPENIPIGTTIIKLNALDLDSGL 962
G + F++ + P DVDQ + + + E+ G + +++ D+G+
Sbjct: 468 GASIFSVNALDP------DVDQNAQVSYSLAEDTLQGAPLSSYVSINSDTGI 513
Score = 54.4 bits (125), Expect = 3e-06
Identities = 79/313 (25%), Positives = 131/313 (41%), Gaps = 30/313 (9%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLT--IPLTVPRGLT- 139
V + I DVNDNVP + T T+ E P G +F + L + ++PR L
Sbjct: 333 VLITILDVNDNVPEVVVTSGSRTIAESAPPGTVIALFQVFDRDSGLNGLVTCSIPRSLPF 392
Query: 140 -IFKDIRAFDRDKPNTP--NSDVH-YSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
+ K + + R N +V Y+I V+ D G L + L + D
Sbjct: 393 ELEKSVGNYYRLVTNAALDREEVFLYNITVTATDKGTPPLSTETIISLNVADTNDNPPTF 452
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL----ISGNDRKLF-SLDSV 249
+ +F ++A+D D+ A + Y L + G + S++S
Sbjct: 453 PHSSYSVYVLENNPRGASIFS--VNALDPDVDQNAQVSYSLAEDTLQGAPLSSYVSINSD 510
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF--- 306
G L+ + D + +LQ L V AS +P ++ + + +LD NDN PE
Sbjct: 511 TGILYALRSFDYEQLRDLQ-----LWVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYP 565
Query: 307 EVDFYNISIVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGW 360
+ + VE P G+ V +V+A D+D G+N +Y+L G FS+ +G
Sbjct: 566 ALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGE 625
Query: 361 LTVRNQTVLDREA 373
+ + +LDR+A
Sbjct: 626 VRTA-RALLDRDA 637
Score = 54.0 bits (124), Expect = 4e-06
Identities = 73/307 (23%), Positives = 127/307 (41%), Gaps = 29/307 (9%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTV-DELTPTGEKAFIFLIAP-IGPSLTIPLTVPRGLTI 140
V V I D+NDN P FL V + + P+ + + P +G + +
Sbjct: 119 VEVEIVDINDNTPRFLKEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSHF 178
Query: 141 FKDIRAFDRDKPNTPN----------SDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDY 190
D+++ + P P + Y +V DG + SS +L+ VLD
Sbjct: 179 SVDVQS-EAHGPKYPELVLEGTLDREGEAVYRLVLTAMDGGDPVRSSVAQILVT--VLDV 235
Query: 191 DAGDKEFQLVIMASGKRIHKEILFPE-PIHAIDQDLGVGATLRYELISGNDR--KLFSLD 247
+ F + + + P + A DQD GV + Y + ++ ++F L+
Sbjct: 236 NDNTPMFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFVKITEKISQIFCLN 295
Query: 248 SVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFE 307
+ G + LD + ++ + L V+A + P +A+V I +LD+NDN+PE
Sbjct: 296 VLTGEISTSANLDYE-----DSSFYELGVEAR--DGPGLRDRAKVLITILDVNDNVPEVV 348
Query: 308 VDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKG-AFSIDPRSG-WLTVRN 365
V + +I E+ P G + D+D G NG T + P+ F ++ G + +
Sbjct: 349 VTSGSRTIAESAPPGTVIALFQVFDRDSGLNGLVTCSI--PRSLPFELEKSVGNYYRLVT 406
Query: 366 QTVLDRE 372
LDRE
Sbjct: 407 NAALDRE 413
Score = 50.0 bits (114), Expect = 6e-05
Identities = 60/220 (27%), Positives = 86/220 (39%), Gaps = 23/220 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I E+ P GT I D DSGLNG + + P +L V Y+
Sbjct: 356 IAESAPPGTVIALFQVFDRDSGLNGLVTCSIPRSL---PFELEKS---VGNYY------- 402
Query: 1000 HVIVARSLPPESEFRLNIS--ALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
++ +L E F NI+ A D G L+ + + V D ND+ P F + Y+ V
Sbjct: 403 RLVTNAALDREEVFLYNITVTATDKGTPPLSTETIISLNVADTNDNPPTFPHSSYSVYVL 462
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTY-----FIQPSDTDLPFEISPLTGVLSVNGELDR 1110
E + V+A D D QNA ++Y +Q + I+ TG+L D
Sbjct: 463 ENNPRGASIFSVNALDPDVDQNAQVSYSLAEDTLQGAPLSSYVSINSDTGILYALRSFDY 522
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
E L V A D+G D NDN+P+
Sbjct: 523 EQLRDLQLWVTASDSG-DPPLSSNVSLSLFVLDQNDNAPE 561
Score = 43.6 bits (98), Expect = 0.006
Identities = 44/169 (26%), Positives = 67/169 (39%), Gaps = 10/169 (5%)
Query: 992 FVINERHGHVIVARSLPPESEFRLNISALDGGNL--NDNIS---VRVFVKDVNDHFPVFK 1046
F +N R+G ++ A + E + L N+ D ++ V V + D+ND+ P F
Sbjct: 75 FSLNPRNGSLVTAGRIDREELCAQSPRCLVSFNILVEDKLNLYPVEVEIVDINDNTPRFL 134
Query: 1047 KTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD---TDLPFEI-SPLTGVL 1102
K + E ++ D D G N+ + + + D+ E P L
Sbjct: 135 KEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSHFSVDVQSEAHGPKYPEL 194
Query: 1103 SVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
+ G LDRE E Y L + A D G DVNDN+P F
Sbjct: 195 VLEGTLDREGEAVYRLVLTAMDGG-DPVRSSVAQILVTVLDVNDNTPMF 242
Score = 40.7 bits (91), Expect = 0.039
Identities = 39/126 (30%), Positives = 62/126 (49%), Gaps = 9/126 (7%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
++S +LFSL+ NGSL +D + L A + V + L K VE+
Sbjct: 66 IVSRGRMQLFSLNPRNGSLVTAGRIDRE---ELCAQSPRCLVSFNILVED-KLNLYPVEV 121
Query: 295 ELLDLNDNLPEFEVDFYNISIVEN-LPNG-FSVLQVMATDKDQGENGEFTYQLDDPKGAF 352
E++D+NDN P F + + I+EN P+ F +++V D D G N ++L F
Sbjct: 122 EIVDINDNTPRFLKEELEVKILENAAPSSRFPLMEVY--DPDVGMNSLQGFKLSG-NSHF 178
Query: 353 SIDPRS 358
S+D +S
Sbjct: 179 SVDVQS 184
Score = 40.7 bits (91), Expect = 0.039
Identities = 39/132 (29%), Positives = 60/132 (45%), Gaps = 13/132 (9%)
Query: 436 DEQLMSFVNVEVTLLDANDNNP-VFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPD 488
D L S V++ + +LD NDN P + P S E + +S A+ G ++ KV AVD D
Sbjct: 539 DPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRS-AEPGYLVTKVVAVDRD 597
Query: 489 LGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPS 546
GQN + Y L + S + F + +TG V A + + + +L V D P
Sbjct: 598 SGQNAWLSYRLLKASEPGL---FSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPL 654
Query: 547 ERRYSLAVVTIE 558
+L V +
Sbjct: 655 SATVTLTVAVAD 666
Score = 38.7 bits (86), Expect = 0.16
Identities = 74/317 (23%), Positives = 121/317 (38%), Gaps = 47/317 (14%)
Query: 1093 FEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY 1152
F ++P G L G +DRE + N D+NDN+P+F
Sbjct: 75 FSLNPRNGSLVTAGRIDREELCAQSPRCLVSFNILVEDKLNLYPVEVEIVDINDNTPRF- 133
Query: 1153 AFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNG 1212
E LE K E S+ ++ VY + N+ G ++ D +G
Sbjct: 134 -LKEELEVKILENAAPSSR----FPLMEVYDPDVGMNSLQGFKLSGNSHFSVDVQSEAHG 188
Query: 1213 -----LILYSLPQRKNQ---------QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFI 1258
L+L R+ + + G P SS A ++VTV DV D M +PV
Sbjct: 189 PKYPELVLEGTLDREGEAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFTQPV-- 246
Query: 1259 SRYYELEIEENVNAPVELVSLNLTEHYENFKMRY-YILNENDTDIRRTFVIDPRNGTLYL 1317
Y + + EN+ ++++ T+ E Y + I + F ++ G +
Sbjct: 247 ---YRVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFVKITEKISQIFCLNVLTGEIST 303
Query: 1318 VRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNS 1377
+ D E YE+ V A R+ P + + KV++ I DVNDN
Sbjct: 304 SANLDYEDSSFYELGVEA------RDGPGL-------------RDRAKVLITILDVNDNV 344
Query: 1378 PK--FTNGNRPLVTAIP 1392
P+ T+G+R + + P
Sbjct: 345 PEVVVTSGSRTIAESAP 361
>AF152486-1|AAD43747.1| 814|Homo sapiens protocadherin alpha 8 short
form protein protein.
Length = 814
Score = 101 bits (243), Expect = 2e-20
Identities = 137/508 (26%), Positives = 202/508 (39%), Gaps = 88/508 (17%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
++G +F +DRE+ V ++ V + ++D NDNPPVF +
Sbjct: 80 QNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDVNDNPPVFRVKDQK 139
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
F+ E+ + ++ A+DAD G N++ Y L + F +D N S
Sbjct: 140 LFVSESRMPDSRFPLEG---ASDADVGANSVLTYRL--SSHDYFMLDVN---------SK 185
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
+ E K++ LV R + + + + KPE L GT
Sbjct: 186 NDENKLV---ELVLRKSLDREDAPAHHLFLTATDGGKPE-----------------LTGT 225
Query: 914 AGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
++ V N A +Q I EN GTT+IKLNA D D G NG I Y FNS
Sbjct: 226 VQL-LVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSL 284
Query: 974 VYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGGN--LNDNI 1029
V V +F I+ G +++ +L E E +++ I A D G+ + +
Sbjct: 285 V----------ETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHC 334
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
+V V + D ND+ P T + V E V+ + D D G N +T + P
Sbjct: 335 TVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMP--- 391
Query: 1090 DLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+PF+ +S S ++ LDRE Y L V ARD G DVND
Sbjct: 392 HVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGG-SPSLWATASLSVEVADVND 450
Query: 1147 NSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDF 1206
N+P F PE Y ++EN P G + V A D D
Sbjct: 451 NAPAF---------AQPE-----------------YTVFVKENNPPGCHIFTVSARDAD- 483
Query: 1207 IGNGNGLILYSLPQRKNQQNLGLPSLSS 1234
N L+ YSL +R+ +G SLSS
Sbjct: 484 -AQENALVSYSLVERR----VGERSLSS 506
Score = 90.6 bits (215), Expect = 4e-17
Identities = 99/407 (24%), Positives = 168/407 (41%), Gaps = 31/407 (7%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + VT+LD NDN P F S YE + NA GT + K+ A DPD G NG + Y
Sbjct: 221 ELTGTVQLLVTVLDVNDNAPTFEQSE-YEVRIFENADNGTTVIKLNASDPDEGANGAISY 279
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPIL--EGRHALFVEASDQPANPSERRYSLAVV 555
+ F I+ NTG + + + E + + ++A+D+ P ++ V
Sbjct: 280 SFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVR 339
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
++ ++P+ V + GT + I VND + + +
Sbjct: 340 ILD-------KNDNVPEIALTSLSLPVREDAQFGTVIALISVNDL--DSGANGQVTCSLM 390
Query: 616 EGVPF-AVEERSGVITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVND 671
VPF V ++V D L R Y+ A + +L + +V V DVND
Sbjct: 391 PHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVND 450
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLI----ANQQDVT 727
+ ++ +F VKEN+ IF + V + + ++ ++
Sbjct: 451 NAPAFAQPEYT--VF-VKENNPPGC--HIFTVSARDADAQENALVSYSLVERRVGERSLS 505
Query: 728 DDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
I++ E G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 506 SYISVHTESGKVYALQPLDHEELELLQFQVSAR-DAGVPPLGSNVTLQVFVLDENDNAPA 564
Query: 787 FEHATYEGFIMENSK-IGTEIKMDNI---IKATDADEGTNALFMYTL 829
G SK + + ++ ++A DAD G NA Y L
Sbjct: 565 LLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYEL 611
Score = 79.8 bits (188), Expect = 7e-14
Identities = 112/477 (23%), Positives = 189/477 (39%), Gaps = 34/477 (7%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +V+V + D NDN PVF + F +S + A D D+G
Sbjct: 105 HLEVIVDRPLQVFHVDVEVKDVNDNPPVFRVKDQKLFVSESRMP-DSRFPLEGASDADVG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE---GRHALFVEASDQPANPSE 547
N ++ Y L + K + N V + H LF+ A+D
Sbjct: 164 ANSVLTYRLSSHDYFMLDVNSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELT 223
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QND 605
L V ++V + P F + YE + N GT+V ++ +D E
Sbjct: 224 GTVQLLVTVLDV-------NDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGA 276
Query: 606 VSYDLLHGYEEGV--PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNAT 663
+SY E V F+++ +G I + +L +Y + + + + + T
Sbjct: 277 ISYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKI-LIDATDKGHPPMAGHCT 335
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIAN 722
V +V + D+ + + A + + V+E++ G I I +++ + G V +
Sbjct: 336 V-LVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALI---SVNDLDSGANGQVTCSLMP 391
Query: 723 QQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEND 782
++ LDRE+ Y + V A + G S +++ + D ND
Sbjct: 392 HVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTAR-DGGSPSLWATASLSVEVADVND 450
Query: 783 NPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEG--KEM 836
N P F Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 451 NAPAFAQPEYTVFVKENNPPGCHI---FTVSARDADAQENALVSYSLVERRVGERSLSSY 507
Query: 837 FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 508 ISVHTESGKV-YALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAP 563
Score = 70.1 bits (164), Expect = 6e-11
Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 16/163 (9%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGS-----LFLEKELDLDAEHNLQANTFVL 274
A D D+G + L Y L S +D + ++S N L L K LD + A L
Sbjct: 157 ASDADVGANSVLTYRL-SSHDYFMLDVNSKNDENKLVELVLRKSLDRE-----DAPAHHL 210
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A+ P T ++ + +LD+NDN P FE Y + I EN NG +V+++ A+D D
Sbjct: 211 FLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPD 270
Query: 335 QGENGEFTYQLDDPKGA-----FSIDPRSGWLTVRNQTVLDRE 372
+G NG +Y + FSID +G + +R ++E
Sbjct: 271 EGANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQE 313
Score = 65.3 bits (152), Expect = 2e-09
Identities = 65/237 (27%), Positives = 103/237 (43%), Gaps = 10/237 (4%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
V V+DVND + + IF +N G + ++ ++ NG + F +
Sbjct: 230 VTVLDVNDNAPTFEQSEYEVRIFENADN--GTTVIKLNASDPDE-GANGAISYSFNSLVE 286
Query: 724 QDVTDDIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEND 782
V D +I + G I + LD E+ ++Y++ + A +KG AG V + I D+ND
Sbjct: 287 TMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDAT-DKGHPPMAGHCTVLVRILDKND 345
Query: 783 NPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDEN 842
N P + + E+++ GT I + I D D G N +L
Sbjct: 346 NVPEIALTSLSLPVREDAQFGTVIAL---ISVNDLDSGANGQVTCSLMPHVPFKLVSTFK 402
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTGGLS--SEAELIIMIGDENDNKPEFNQIE 897
+ +LDRE+ Y+L + ARD G S + A L + + D NDN P F Q E
Sbjct: 403 NYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPE 459
Score = 64.9 bits (151), Expect = 2e-09
Identities = 63/221 (28%), Positives = 94/221 (42%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y E +
Sbjct: 443 VEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL-VERRVGE 501
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVF 1034
LS+ Y ++ G V + L E + +SA D G L N++++VF
Sbjct: 502 RSLSS-------YISVHTESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVF 554
Query: 1035 VKDVNDHFPVFKKTWYNFN-------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQP- 1086
V D ND+ P + V + V+ KV A DAD G NA L+Y +QP
Sbjct: 555 VLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPA 614
Query: 1087 -SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
S +PF + TG +S LD ++ L V+ +D+G
Sbjct: 615 ASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHG 655
Score = 60.9 bits (141), Expect = 3e-08
Identities = 67/277 (24%), Positives = 113/277 (40%), Gaps = 25/277 (9%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKL---FSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
++A D D G + Y S + + FS+D G + + LD + E N + +
Sbjct: 264 LNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQE-----NLYKI 318
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A+ +P V + +LD NDN+PE + ++ + E+ G + + D D
Sbjct: 319 LIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLD 378
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
G NG+ T L + + ++ + LDRE S+ + V A++ +PS+ T
Sbjct: 379 SGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWAT 438
Query: 394 FADSQRIAKWRRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDAN 453
+ S +A + NAP + P+ EN + V DA
Sbjct: 439 ASLSVEVA-----DVNDNAP----AFAQPEYTVFVKEN----NPPGCHIFTVSARDADAQ 485
Query: 454 DNNPV---FVPSNLYEFSMKSNAKVGTVIGKVKAVDP 487
+N V V + E S+ S V T GKV A+ P
Sbjct: 486 ENALVSYSLVERRVGERSLSSYISVHTESGKVYALQP 522
Score = 59.7 bits (138), Expect = 8e-08
Identities = 70/293 (23%), Positives = 119/293 (40%), Gaps = 24/293 (8%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPI-- 124
L G +++ + + V + DVNDN P F + Y V + E G +
Sbjct: 212 LTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDE 271
Query: 125 GPSLTIPLTVPRGL-TIFKDIRAFDRDKPNT--------PNSDVHYSIVSGNDDGHFALE 175
G + I + + T+ D + DR+ +++ ++ D GH +
Sbjct: 272 GANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPM- 330
Query: 176 SSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI---DQDLGVGATLR 232
+ H VL+ ++LD + D ++ + + + ++ F I I D D G +
Sbjct: 331 AGHCTVLV--RILDKN--DNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVT 386
Query: 233 YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV 292
L+ KL S SL L+ LD + + + + L V A +P A A +
Sbjct: 387 CSLMPHVPFKLVSTFKNYYSLVLDSALDRE-----RVSAYELVVTARDGGSPSLWATASL 441
Query: 293 EIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+E+ D+NDN P F Y + + EN P G + V A D D EN +Y L
Sbjct: 442 SVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL 494
Score = 54.0 bits (124), Expect = 4e-06
Identities = 67/241 (27%), Positives = 101/241 (41%), Gaps = 23/241 (9%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
++ + KN ++ + E+ GT I ++ DLDSG NGQ+ V
Sbjct: 337 LVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHV--- 393
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN--LNDNISVRV 1033
P KL + K Y+ + ++ +L E S + L ++A DGG+ L S+ V
Sbjct: 394 PFKLVST---FKNYYSL-------VLDSALDRERVSAYELVVTARDGGSPSLWATASLSV 443
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTD 1090
V DVND+ P F + Y V+E + V A DAD +NA ++Y + + +
Sbjct: 444 EVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERS 503
Query: 1091 LPFEISPLT--GVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
L IS T G + LD E + V ARD G D NDN+
Sbjct: 504 LSSYISVHTESGKVYALQPLDHEELELLQFQVSARDAG-VPPLGSNVTLQVFVLDENDNA 562
Query: 1149 P 1149
P
Sbjct: 563 P 563
Score = 44.0 bits (99), Expect = 0.004
Identities = 32/110 (29%), Positives = 54/110 (49%), Gaps = 7/110 (6%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L+VTV DV D + P F YE+ I EN + ++ LN ++ E
Sbjct: 218 GKPELTGTVQLLVTVLDVND-----NAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
N + Y + +T + F ID G + + + D E ++ Y++++ A
Sbjct: 273 ANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDA 322
Score = 43.2 bits (97), Expect = 0.007
Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 9/110 (8%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKV------GTVIGKVKAVDPDLGQN 492
L S V ++V +LD NDN P + + ++ V G V+ KV+AVD D G N
Sbjct: 545 LGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYN 604
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAE--SPILEGRHALFVEASD 540
+ Y+LQ ++ + PF++ TG +S RH L V D
Sbjct: 605 AWLSYELQPAAS-SPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKD 653
Score = 40.3 bits (90), Expect = 0.052
Identities = 40/131 (30%), Positives = 64/131 (48%), Gaps = 12/131 (9%)
Query: 221 IDQDLGVG-ATL---RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQ 275
I QDLG+ A L + + S R L + NG LF+ +D + A + L+
Sbjct: 48 IAQDLGLELAELVPRLFRVASKRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLE 107
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVEN-LPNGFSVLQVMATDKD 334
V ++ PL+ V++E+ D+NDN P F V + + E+ +P+ L+ A+D D
Sbjct: 108 VI---VDRPLQVFH--VDVEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLE-GASDAD 161
Query: 335 QGENGEFTYQL 345
G N TY+L
Sbjct: 162 VGANSVLTYRL 172
Score = 35.9 bits (79), Expect = 1.1
Identities = 51/191 (26%), Positives = 77/191 (40%), Gaps = 20/191 (10%)
Query: 218 IHAIDQDLGVGATLRYELISGN--DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTF 272
+ A D D A + Y L+ +R L S SV+ G ++ + LD + LQ
Sbjct: 477 VSARDADAQENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEELELLQ---- 532
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLP---EFEVDFYNISIVENLPN----GFSV 325
QV A P + +++ +LD NDN P E V + + +P G V
Sbjct: 533 -FQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVV 591
Query: 326 LQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLT--VRNQTVLDREAHSSLRMKVYA 383
+V A D D G N +Y+L + I R G T + VLD R+ V
Sbjct: 592 AKVRAVDADSGYNAWLSYELQPAASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLV 651
Query: 384 KE-TNPSVVGT 393
K+ P++ T
Sbjct: 652 KDHGEPALTAT 662
>AF152331-1|AAD43725.1| 931|Homo sapiens protocadherin gamma B2
protein.
Length = 931
Score = 101 bits (243), Expect = 2e-20
Identities = 117/474 (24%), Positives = 202/474 (42%), Gaps = 43/474 (9%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E ++ + V + D NDN P+F + + + + K GT A+D D+G N +
Sbjct: 111 ENPLNIFYIAVIVQDINDNTPLFKQTKI-NLKIGESTKPGTTFPLDPALDSDVGPNSLQR 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVT 556
Y L + + + + + H+L + +
Sbjct: 170 YHLNDNEYFDLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIR 229
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGY 614
I+VT + P P F Y + +V G V Q+ D E +++Y H
Sbjct: 230 IKVT--DANDNP--PVFSQDVYRVTLREDVPPGFFVLQVTATDRDEGINAEITYS-FHNV 284
Query: 615 EEGVP--FAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVND- 671
+E V F + E++G IT DDL Y ++ ++ +L+ + V ++D ND
Sbjct: 285 DEQVKHFFNLNEKTGEITTKDDLDFEIASSYTL-SIEAKDPGDLAAHCSIQVEILDDNDC 343
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSS-----IYGNGTGNVRFLIANQQDV 726
V++ +P+ +++ G I I + S +Y GN +F++ +
Sbjct: 344 APEVIVTSVSTPL---PEDSPPGTVIALIKTRDRDSGENGEVYCQVLGNAKFILKSSS-- 398
Query: 727 TDDIAIAEDGTIFTQKPLDREKRDVYRMTVIA-EFNKGVISGAGIYQVTIYIEDENDNPP 785
+ + DG LDRE+ Y +T+ A + K +S + I VT++I D NDN P
Sbjct: 399 KNYYKLVTDGA------LDREEIPEYNLTITATDGGKPPLSSSII--VTLHISDVNDNAP 450
Query: 786 VFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG---EGKEMF---DV 839
VF+ +Y + EN+ G I I A+D D G + Y++ + +E+ V
Sbjct: 451 VFQQTSYMVHVAENNPPGASIAQ---ISASDPDLGPSGQVSYSIVASDLKPREILSYVSV 507
Query: 840 DENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
+GVV F + D E+ ++L+L ARD G LS+ L +++GD NDN P
Sbjct: 508 SAQSGVV-FAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAP 560
Score = 83.8 bits (198), Expect = 4e-15
Identities = 59/177 (33%), Positives = 95/177 (53%), Gaps = 21/177 (11%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSL---DSVNG----SLFLEKELDLDAEHNLQANTF 272
A+D D+G + RY L ND + F L + +G L L+ LD + EH+L
Sbjct: 157 ALDSDVGPNSLQRYHL---NDNEYFDLAEKQTPDGRKYPELILKHSLDRE-EHSLHQ--- 209
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
L + A +P ++ ++ I++ D NDN P F D Y +++ E++P GF VLQV ATD
Sbjct: 210 -LVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVYRVTLREDVPPGFFVLQVTATD 268
Query: 333 KDQGENGEFTYQL----DDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE 385
+D+G N E TY + K F+++ ++G +T ++ LD E SS + + AK+
Sbjct: 269 RDEGINAEITYSFHNVDEQVKHFFNLNEKTGEITTKDD--LDFEIASSYTLSIEAKD 323
Score = 79.0 bits (186), Expect = 1e-13
Identities = 51/152 (33%), Positives = 78/152 (51%), Gaps = 8/152 (5%)
Query: 744 LDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIG 803
LDRE+ ++++ V+ + G +G Q+ I + D NDNPPVF Y + E+ G
Sbjct: 200 LDREEHSLHQL-VLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVYRVTLREDVPPG 258
Query: 804 TEIKMDNIIKATDADEGTNALFMYTLFG---EGKEMFDVDENTGVVKFIGDSLDREKKIM 860
+ + ATD DEG NA Y+ + K F+++E TG + D LD E
Sbjct: 259 FFVLQ---VTATDRDEGINAEITYSFHNVDEQVKHFFNLNEKTGEIT-TKDDLDFEIASS 314
Query: 861 YKLSLVARDTGGLSSEAELIIMIGDENDNKPE 892
Y LS+ A+D G L++ + + I D+ND PE
Sbjct: 315 YTLSIEAKDPGDLAAHCSIQVEILDDNDCAPE 346
Score = 78.6 bits (185), Expect = 2e-13
Identities = 65/239 (27%), Positives = 108/239 (45%), Gaps = 19/239 (7%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+E+ N A +V +PE+ P GT I + D DSG NG++ + +
Sbjct: 335 VEILDDNDCAPEVIVTSVSTPLPEDSPPGTVIALIKTRDRDSGENGEVYCQV-----LGN 389
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESEFRLNISALDGGN--LNDNISVRVFVK 1036
+K + Y ++ + + +P E+ L I+A DGG L+ +I V + +
Sbjct: 390 AKFILKSSSKNYYKLVTDG---ALDREEIP---EYNLTITATDGGKPPLSSSIIVTLHIS 443
Query: 1037 DVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTD----LP 1092
DVND+ PVF++T Y +V E + ++ A+D D G + ++Y I SD L
Sbjct: 444 DVNDNAPVFQQTSYMVHVAENNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREILS 503
Query: 1093 F-EISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
+ +S +GV+ D E + LT+ ARD G D+NDN+P+
Sbjct: 504 YVSVSAQSGVVFAQRAFDHEQLRAFELTLQARDQG-SPALSANVSLRVLVGDLNDNAPR 561
Score = 74.9 bits (176), Expect = 2e-12
Identities = 60/212 (28%), Positives = 95/212 (44%), Gaps = 14/212 (6%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
E++P G ++++ A D D G+N +I Y F++ D +VK +F +NE+ G +
Sbjct: 253 EDVPPGFFVLQVTATDRDEGINAEITYSFHN----------VDE-QVKHFFNLNEKTGEI 301
Query: 1002 IVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVNDHFPVFKKTWYNFNVEEAQY 1059
L E S + L+I A D G+L + S++V + D ND P T + + E
Sbjct: 302 TTKDDLDFEIASSYTLSIEAKDPGDLAAHCSIQVEILDDNDCAPEVIVTSVSTPLPEDSP 361
Query: 1060 TRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTGVLSVNGELDRETEDKYILT 1119
V+ + D D G+N + + + + S L +G LDRE +Y LT
Sbjct: 362 PGTVIALIKTRDRDSGENGEVYCQVLGNAKFILKSSSKNYYKLVTDGALDREEIPEYNLT 421
Query: 1120 VVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
+ A D G DVNDN+P F
Sbjct: 422 ITATDGG-KPPLSSSIIVTLHISDVNDNAPVF 452
Score = 68.9 bits (161), Expect = 1e-10
Identities = 59/194 (30%), Positives = 88/194 (45%), Gaps = 17/194 (8%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP-PSKLSADALEVKRYFVINERH 998
I E+ GTT ALD D G N RY N Y K + D ++
Sbjct: 142 IGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYFDLAEKQTPDG----------RKY 191
Query: 999 GHVIVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNV 1054
+I+ SL E S +L ++A+DGG+ + +R+ V D ND+ PVF + Y +
Sbjct: 192 PELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVYRVTL 251
Query: 1055 EEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLP--FEISPLTGVLSVNGELDRET 1112
E + +V ATD D G NA +TY D + F ++ TG ++ +LD E
Sbjct: 252 REDVPPGFFVLQVTATDRDEGINAEITYSFHNVDEQVKHFFNLNEKTGEITTKDDLDFEI 311
Query: 1113 EDKYILTVVARDNG 1126
Y L++ A+D G
Sbjct: 312 ASSYTLSIEAKDPG 325
Score = 66.1 bits (154), Expect = 9e-10
Identities = 50/170 (29%), Positives = 80/170 (47%), Gaps = 13/170 (7%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
E G + +DRE+ + + +F+ + I+ + + ++D NDN P+F+
Sbjct: 80 ESGDLLVSDRIDREQICGKQPLCVLDFDTVAENPLNIFYIAVIVQDINDNTPLFKQTKIN 139
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDV------DENTGVVK 847
I E++K GT +D A D+D G N+L Y L E FD+ D
Sbjct: 140 LKIGESTKPGTTFPLD---PALDSDVGPNSLQRYHL--NDNEYFDLAEKQTPDGRKYPEL 194
Query: 848 FIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+ SLDRE+ +++L L A D G S ++ I + D NDN P F+Q
Sbjct: 195 ILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQ 244
Score = 62.1 bits (144), Expect = 1e-08
Identities = 66/282 (23%), Positives = 122/282 (43%), Gaps = 33/282 (11%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRGLTIF- 141
+ V ++D+NDN P+F T ++ + E T G P+ P+L + P L +
Sbjct: 119 IAVIVQDINDNTPLFKQTKINLKIGESTKPGTTF------PLDPALDSDVG-PNSLQRYH 171
Query: 142 -KDIRAFDRDKPNTPNSDVHYSIV---SGNDDGHF-------ALESSHKP----VLLLRK 186
D FD + TP+ + ++ S + + H A++ P + K
Sbjct: 172 LNDNEYFDLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGGDPPQSGTTQIRIK 231
Query: 187 VLDYDAGDKEF-QLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGND--RKL 243
V D + F Q V + + F + A D+D G+ A + Y + ++ +
Sbjct: 232 VTDANDNPPVFSQDVYRVTLREDVPPGFFVLQVTATDRDEGINAEITYSFHNVDEQVKHF 291
Query: 244 FSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNL 303
F+L+ G + + +LD + A+++ L ++A + A +++E+LD ND
Sbjct: 292 FNLNEKTGEITTKDDLDFEI-----ASSYTLSIEAKDPGD--LAAHCSIQVEILDDNDCA 344
Query: 304 PEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
PE V + + E+ P G + + D+D GENGE Q+
Sbjct: 345 PEVIVTSVSTPLPEDSPPGTVIALIKTRDRDSGENGEVYCQV 386
Score = 59.3 bits (137), Expect = 1e-07
Identities = 60/199 (30%), Positives = 91/199 (45%), Gaps = 21/199 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
+ EN P G +I +++A D D G +GQ+ Y + P LS Y ++ + G
Sbjct: 461 VAENNPPGASIAQISASDPDLGPSGQVSYSIVASDLKPREILS--------YVSVSAQSG 512
Query: 1000 HVIVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFP--VFKKTWYNFN 1053
V R+ E F L + A D G+ L+ N+S+RV V D+ND+ P ++ + +
Sbjct: 513 VVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGS 572
Query: 1054 -----VEEAQYTRRVLGKVDATDADFGQNANLTYFI-QPSDTDLPFEISPLTGVLSVNGE 1107
V A ++ KV A DAD G NA L+Y + Q S+ L F + TG +
Sbjct: 573 ALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGL-FSLGLRTGEVRTARA 631
Query: 1108 LDRETEDKYILTVVARDNG 1126
L + L V RD G
Sbjct: 632 LGDRDAARQRLLVAVRDGG 650
Score = 58.8 bits (136), Expect = 1e-07
Identities = 64/288 (22%), Positives = 117/288 (40%), Gaps = 17/288 (5%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGP 126
L + G S + + + D NDN P+F Y VT+ E P G F+ +
Sbjct: 212 LTAVDGGDPPQSGTTQIRIKVTDANDNPPVFSQDVYRVTLREDVPPG--FFVLQVTATDR 269
Query: 127 SLTIPLTVPRGL-TIFKDIRAF----DRDKPNTPNSDVHYSIVSGNDDGHFALESSHKPV 181
I + + + ++ F ++ T D+ + I S A +
Sbjct: 270 DEGINAEITYSFHNVDEQVKHFFNLNEKTGEITTKDDLDFEIASSYTLSIEAKDPGDLAA 329
Query: 182 LLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI----DQDLGVGATLRYELIS 237
+V D D ++++ + + ++ P + A+ D+D G + Y +
Sbjct: 330 HCSIQVEILDDNDCAPEVIVTSVSTPLPEDSP-PGTVIALIKTRDRDSGENGEV-YCQVL 387
Query: 238 GNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELL 297
GN + + S N L + LD E + N L + A+ P ++ V + +
Sbjct: 388 GNAKFILKSSSKN-YYKLVTDGALDREEIPEYN---LTITATDGGKPPLSSSIIVTLHIS 443
Query: 298 DLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
D+NDN P F+ Y + + EN P G S+ Q+ A+D D G +G+ +Y +
Sbjct: 444 DVNDNAPVFQQTSYMVHVAENNPPGASIAQISASDPDLGPSGQVSYSI 491
Score = 53.6 bits (123), Expect = 5e-06
Identities = 51/163 (31%), Positives = 74/163 (45%), Gaps = 10/163 (6%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I T+ LD E Y +++ A+ + G ++ QV I D+ND P +
Sbjct: 299 GEITTKDDLDFEIASSYTLSIEAK-DPGDLAAHCSIQVEIL--DDNDCAPEVIVTSVSTP 355
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGD-SLD 854
+ E+S GT I + IK D D G N + G K + + K + D +LD
Sbjct: 356 LPEDSPPGTVIAL---IKTRDRDSGENGEVYCQVLGNAKFILK-SSSKNYYKLVTDGALD 411
Query: 855 REKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
RE+ Y L++ A D G LSS + + I D NDN P F Q
Sbjct: 412 REEIPEYNLTITATDGGKPPLSSSIIVTLHISDVNDNAPVFQQ 454
Score = 53.2 bits (122), Expect = 7e-06
Identities = 49/185 (26%), Positives = 77/185 (41%), Gaps = 12/185 (6%)
Query: 976 IPPSKLSADALEVKRYFVINERHGHVIVARSLPPESEF-RLNISALDGGNLNDN----IS 1030
+P KL A K YF +N G ++V+ + E + + LD + +N
Sbjct: 61 LPARKLRVSA--EKEYFTVNPESGDLLVSDRIDREQICGKQPLCVLDFDTVAENPLNIFY 118
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD-T 1089
+ V V+D+ND+ P+FK+T N + E+ A D+D G N+ Y + ++
Sbjct: 119 IAVIVQDINDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYF 178
Query: 1090 DLPFEISP---LTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
DL + +P L + LDRE + L + A D G D ND
Sbjct: 179 DLAEKQTPDGRKYPELILKHSLDREEHSLHQLVLTAVDGG-DPPQSGTTQIRIKVTDAND 237
Query: 1147 NSPKF 1151
N P F
Sbjct: 238 NPPVF 242
Score = 49.6 bits (113), Expect = 8e-05
Identities = 50/172 (29%), Positives = 81/172 (47%), Gaps = 24/172 (13%)
Query: 218 IHAIDQDLGVGATLRYELISGN--DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTF 272
I A D DLG + Y +++ + R++ S SV+ G +F ++ D + Q F
Sbjct: 474 ISASDPDLGPSGQVSYSIVASDLKPREILSYVSVSAQSGVVFAQRAFDHE-----QLRAF 528
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF---EVDFYNISIVENLPN----GFSV 325
L +QA +P +A + + + DLNDN P + ++ + +P G+ V
Sbjct: 529 ELTLQARDQGSPALSANVSLRVLVGDLNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLV 588
Query: 326 LQVMATDKDQGENGEFTY---QLDDPKGAFSIDPRSGWLTVRNQTVL-DREA 373
+V+A D D G N +Y Q +P G FS+ R+G VR L DR+A
Sbjct: 589 TKVVAVDADSGHNAWLSYHVLQASEP-GLFSLGLRTG--EVRTARALGDRDA 637
Score = 45.6 bits (103), Expect = 0.001
Identities = 61/246 (24%), Positives = 106/246 (43%), Gaps = 13/246 (5%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L S + V + + D NDN PVF ++ Y + N G I ++ A DPDLG +G V Y
Sbjct: 432 LSSSIIVTLHISDVNDNAPVFQQTS-YMVHVAENNPPGASIAQISASDPDLGPSGQVSYS 490
Query: 499 LQRT--SNLTITSPFKINPNTGTVSVAESPILEGRHA--LFVEASDQPANPSERRYSLAV 554
+ + I S ++ +G V + E A L ++A DQ + SL V
Sbjct: 491 IVASDLKPREILSYVSVSAQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRV 550
Query: 555 VTIEVT-RGTKGNKPDI-PDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQND--VSYDL 610
+ ++ + P + PD G+ V G V ++ DA ++ +SY +
Sbjct: 551 LVGDLNDNAPRVLYPALGPD--GSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHV 608
Query: 611 LHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVN 670
L E G+ F++ R+G + L + VA+++ + AT+H++ +
Sbjct: 609 LQASEPGL-FSLGLRTGEVRTARALGDRDAARQRL-LVAVRDGGQPPLSATATLHLIFAD 666
Query: 671 DERGVL 676
+ VL
Sbjct: 667 SLQEVL 672
Score = 39.1 bits (87), Expect = 0.12
Identities = 42/172 (24%), Positives = 72/172 (41%), Gaps = 10/172 (5%)
Query: 429 TENIEYYDE-QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDP 487
T +IE D L + +++V +LD ND P + +++ + ++ GTVI +K D
Sbjct: 316 TLSIEAKDPGDLAAHCSIQVEILDDNDCAPEVIVTSV-STPLPEDSPPGTVIALIKTRDR 374
Query: 488 DLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSE 547
D G+NG V + + + S K T + + + L + A+D P
Sbjct: 375 DSGENGEVYCQVLGNAKFILKSSSKNYYKLVTDGALDREEIP-EYNLTITATDGGKPPLS 433
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVND 599
S +VT+ ++ + P F Y V N G S+ QI +D
Sbjct: 434 ---SSIIVTLHIS----DVNDNAPVFQQTSYMVHVAENNPPGASIAQISASD 478
Score = 35.1 bits (77), Expect = 2.0
Identities = 29/108 (26%), Positives = 48/108 (44%), Gaps = 4/108 (3%)
Query: 240 DRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDL 299
+++ F+++ +G L + +D + Q VL + NPL V ++ D+
Sbjct: 71 EKEYFTVNPESGDLLVSDRIDREQICGKQP-LCVLDFD-TVAENPLNIFYIAVIVQ--DI 126
Query: 300 NDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDD 347
NDN P F+ N+ I E+ G + A D D G N Y L+D
Sbjct: 127 NDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLND 174
>AF152326-1|AAD43720.1| 932|Homo sapiens protocadherin gamma A6
protein.
Length = 932
Score = 101 bits (243), Expect = 2e-20
Identities = 112/467 (23%), Positives = 194/467 (41%), Gaps = 27/467 (5%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E ++ VEV ++D NDN P F+ L E + NA + ++ DPD+G N +
Sbjct: 111 EDKLNLYPVEVEIVDINDNTPRFLKEEL-EVKILENAAPSSRFPLMEVYDPDVGMNSLQG 169
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVT 556
+ L S+ ++ + + V E + A++ R S+A +
Sbjct: 170 FKLSGNSHFSVDVQSEAHGPKYPELVLEGTLDREGEAVYRLVLTAMDGGDPVRSSVAQIL 229
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGY 614
+ V + P F Y V N+ +GT V + D E +V+Y +
Sbjct: 230 VTVL----DVNDNTPMFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFVKIT 285
Query: 615 EE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDER 673
E+ F + +G I+ +L + Y+ V ++ L + ++DVND
Sbjct: 286 EKISQIFCLNVLTGEISTSANLDYEDSSFYEL-GVEARDGPGLRDRAKVLITILDVNDNV 344
Query: 674 GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIA 733
++ + S I A+ Q+F + G V I + ++
Sbjct: 345 PEVVVTSGSRTIAESAPPGTVIALFQVFDRDSGL-----NGLVTCSIPRSLPFELEKSVG 399
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
+ T LDRE+ +Y +TV A +KG + +++ + D NDNPP F H++Y
Sbjct: 400 NYYRLVTNAALDREEVFLYNITVTAT-DKGTPPLSTETIISLNVADTNDNPPTFPHSSYS 458
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMY-----TLFGEGKEMF-DVDENTGVVK 847
+++EN+ G I + A D D NA Y TL G + ++ +TG++
Sbjct: 459 VYVLENNPRGASIFS---VNALDPDVDQNAQVSYSLAEDTLQGAPLSSYVSINSDTGIL- 514
Query: 848 FIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
+ S D E+ +L + A D+G LSS L + + D+NDN PE
Sbjct: 515 YALRSFDYEQLRDLQLWVTASDSGDPPLSSNVSLSLFVLDQNDNAPE 561
Score = 86.2 bits (204), Expect = 8e-16
Identities = 70/235 (29%), Positives = 103/235 (43%), Gaps = 27/235 (11%)
Query: 929 LDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LDV+ P+F +PEN+P+GT ++ + A D D G++G++ Y F K+
Sbjct: 233 LDVNDNTPMFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSF--------VKI 284
Query: 982 SADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVN 1039
+ ++ + F +N G + + +L E S + L + A DG L D V + + DVN
Sbjct: 285 TE---KISQIFCLNVLTGEISTSANLDYEDSSFYELGVEARDGPGLRDRAKVLITILDVN 341
Query: 1040 DHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLT 1099
D+ P T + + E+ V+ D D G N +T I S LPFE+
Sbjct: 342 DNVPEVVVTSGSRTIAESAPPGTVIALFQVFDRDSGLNGLVTCSIPRS---LPFELEKSV 398
Query: 1100 G---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
G L N LDRE Y +TV A D G D NDN P F
Sbjct: 399 GNYYRLVTNAALDREEVFLYNITVTATDKG-TPPLSTETIISLNVADTNDNPPTF 452
Score = 71.3 bits (167), Expect = 2e-11
Identities = 44/125 (35%), Positives = 72/125 (57%), Gaps = 7/125 (5%)
Query: 222 DQDLGVGATLRYELISGNDRKLFSLD---SVNGSLFLEKELDLDAEHNLQANTFVLQVQA 278
D D+G+ + ++L SGN FS+D +G + E L+ + +A + L + A
Sbjct: 159 DPDVGMNSLQGFKL-SGNSH--FSVDVQSEAHGPKYPELVLEGTLDREGEA-VYRLVLTA 214
Query: 279 SQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGEN 338
+P++++ A++ + +LD+NDN P F Y +S+ ENLP G VL V ATD+D+G +
Sbjct: 215 MDGGDPVRSSVAQILVTVLDVNDNTPMFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVH 274
Query: 339 GEFTY 343
GE TY
Sbjct: 275 GEVTY 279
Score = 68.9 bits (161), Expect = 1e-10
Identities = 51/167 (30%), Positives = 78/167 (46%), Gaps = 9/167 (5%)
Query: 735 DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEG 794
+G++ T +DRE+ + FN V +Y V + I D NDN P F E
Sbjct: 81 NGSLVTAGRIDREELCAQSPRCLVSFNILVEDKLNLYPVEVEIVDINDNTPRFLKEELEV 140
Query: 795 FIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----IG 850
I+EN+ + +++ D D G N+L + L G DV K+ +
Sbjct: 141 KILENAAPSSRFP---LMEVYDPDVGMNSLQGFKLSGNSHFSVDVQSEAHGPKYPELVLE 197
Query: 851 DSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+LDRE + +Y+L L A D G SS A++++ + D NDN P F Q
Sbjct: 198 GTLDREGEAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFTQ 244
Score = 65.3 bits (152), Expect = 2e-09
Identities = 78/300 (26%), Positives = 122/300 (40%), Gaps = 21/300 (7%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRG 137
S+ + V + DVNDN P+F Y V+V E P G + +T
Sbjct: 223 SSVAQILVTVLDVNDNTPMFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFV 282
Query: 138 LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHF---ALESSHKPVLLLR-KVLD--YD 191
K + F N ++ S +D F +E+ P L R KVL D
Sbjct: 283 KITEKISQIFCL---NVLTGEISTSANLDYEDSSFYELGVEARDGPGLRDRAKVLITILD 339
Query: 192 AGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKL-FSLDSVN 250
D ++V+ SG R E P + A+ Q + L + R L F L+
Sbjct: 340 VNDNVPEVVV-TSGSRTIAESAPPGTVIALFQVFDRDSGLNGLVTCSIPRSLPFELEKSV 398
Query: 251 GSLF-LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
G+ + L LD E N + V A+ P + + + + + D NDN P F
Sbjct: 399 GNYYRLVTNAALDREEVFLYN---ITVTATDKGTPPLSTETIISLNVADTNDNPPTFPHS 455
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQT 367
Y++ ++EN P G S+ V A D D +N + +Y L D +GA P S ++++ + T
Sbjct: 456 SYSVYVLENNPRGASIFSVNALDPDVDQNAQVSYSLAEDTLQGA----PLSSYVSINSDT 511
Score = 64.5 bits (150), Expect = 3e-09
Identities = 82/329 (24%), Positives = 141/329 (42%), Gaps = 24/329 (7%)
Query: 1010 ESEFRLNISALDGGN-LNDNIS-VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKV 1067
E+ +RL ++A+DGG+ + +++ + V V DVND+ P+F + Y +V E + V
Sbjct: 205 EAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFTQPVYRVSVPENLPVGTPVLAV 264
Query: 1068 DATDADFGQNANLTY-FIQPSD-TDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
ATD D G + +TY F++ ++ F ++ LTG +S + LD E Y L V ARD
Sbjct: 265 TATDQDEGVHGEVTYSFVKITEKISQIFCLNVLTGEISTSANLDYEDSSFYELGVEARDG 324
Query: 1126 GXXXXXXXXXXXXXXXXDVNDNSPKFYAFD---ELLEWKHPEADELSNHNFE-SVMMIPV 1181
DVNDN P+ + E P F+ + +
Sbjct: 325 ---PGLRDRAKVLITILDVNDNVPEVVVTSGSRTIAESAPPGTVIALFQVFDRDSGLNGL 381
Query: 1182 YKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILM 1239
+I + P + +V + T+ + + LY++ + G P LS+ I+
Sbjct: 382 VTCSIPRSLPFELEKSVGNYYRLVTNAALDREEVFLYNITVTATDK--GTPPLSTETIIS 439
Query: 1240 VTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEH--YENFKMRYYILNE 1297
+ VAD D + P F Y + + EN + S+N + +N ++ Y + +
Sbjct: 440 LNVADTND-----NPPTFPHSSYSVYVLENNPRGASIFSVNALDPDVDQNAQVSYSLAED 494
Query: 1298 --NDTDIRRTFVIDPRNGTLYLVRSPDRE 1324
+ I+ G LY +RS D E
Sbjct: 495 TLQGAPLSSYVSINSDTGILYALRSFDYE 523
Score = 59.3 bits (137), Expect = 1e-07
Identities = 63/197 (31%), Positives = 93/197 (47%), Gaps = 21/197 (10%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
EN P G +I +NALD D N Q+ Y +E + + LS+ Y IN G +
Sbjct: 463 ENNPRGASIFSVNALDPDVDQNAQVSYSL-AEDTLQGAPLSS-------YVSINSDTGIL 514
Query: 1002 IVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVF----KKTWYNFN 1053
RS E + +L ++A D G+ L+ N+S+ +FV D ND+ P T +
Sbjct: 515 YALRSFDYEQLRDLQLWVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTG 574
Query: 1054 VEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG-VLSVNGELD 1109
VE A + ++ KV A D D GQNA L+Y + + F + TG V + LD
Sbjct: 575 VELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLD 634
Query: 1110 RETEDKYILTVVARDNG 1126
R+ K L V +D+G
Sbjct: 635 RDAL-KQSLVVAVQDHG 650
Score = 55.2 bits (127), Expect = 2e-06
Identities = 61/232 (26%), Positives = 104/232 (44%), Gaps = 22/232 (9%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I T LD E Y + V A G+ A +V I I D NDN P +
Sbjct: 299 GEISTSANLDYEDSSFYELGVEARDGPGLRDRA---KVLITILDVNDNVPEVVVTSGSRT 355
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTG-VVKFIGDS-L 853
I E++ GT I + + D D G N L ++ F+++++ G + + ++ L
Sbjct: 356 IAESAPPGTVIALFQVF---DRDSGLNGLVTCSI--PRSLPFELEKSVGNYYRLVTNAAL 410
Query: 854 DREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
DRE+ +Y +++ A D G LS+E + + + D NDN P F + V E
Sbjct: 411 DREEVFLYNITVTATDKGTPPLSTETIISLNVADTNDNPPTFPHSSYSVYV---LENNPR 467
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPL-FLIPENIPIGTTIIKLNALDLDSGL 962
G + F++ + P DVDQ + + + E+ G + +++ D+G+
Sbjct: 468 GASIFSVNALDP------DVDQNAQVSYSLAEDTLQGAPLSSYVSINSDTGI 513
Score = 54.4 bits (125), Expect = 3e-06
Identities = 79/313 (25%), Positives = 131/313 (41%), Gaps = 30/313 (9%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLT--IPLTVPRGLT- 139
V + I DVNDNVP + T T+ E P G +F + L + ++PR L
Sbjct: 333 VLITILDVNDNVPEVVVTSGSRTIAESAPPGTVIALFQVFDRDSGLNGLVTCSIPRSLPF 392
Query: 140 -IFKDIRAFDRDKPNTP--NSDVH-YSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
+ K + + R N +V Y+I V+ D G L + L + D
Sbjct: 393 ELEKSVGNYYRLVTNAALDREEVFLYNITVTATDKGTPPLSTETIISLNVADTNDNPPTF 452
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL----ISGNDRKLF-SLDSV 249
+ +F ++A+D D+ A + Y L + G + S++S
Sbjct: 453 PHSSYSVYVLENNPRGASIFS--VNALDPDVDQNAQVSYSLAEDTLQGAPLSSYVSINSD 510
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF--- 306
G L+ + D + +LQ L V AS +P ++ + + +LD NDN PE
Sbjct: 511 TGILYALRSFDYEQLRDLQ-----LWVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYP 565
Query: 307 EVDFYNISIVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGW 360
+ + VE P G+ V +V+A D+D G+N +Y+L G FS+ +G
Sbjct: 566 ALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGE 625
Query: 361 LTVRNQTVLDREA 373
+ + +LDR+A
Sbjct: 626 VRTA-RALLDRDA 637
Score = 54.0 bits (124), Expect = 4e-06
Identities = 73/307 (23%), Positives = 127/307 (41%), Gaps = 29/307 (9%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTV-DELTPTGEKAFIFLIAP-IGPSLTIPLTVPRGLTI 140
V V I D+NDN P FL V + + P+ + + P +G + +
Sbjct: 119 VEVEIVDINDNTPRFLKEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSHF 178
Query: 141 FKDIRAFDRDKPNTPN----------SDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDY 190
D+++ + P P + Y +V DG + SS +L+ VLD
Sbjct: 179 SVDVQS-EAHGPKYPELVLEGTLDREGEAVYRLVLTAMDGGDPVRSSVAQILVT--VLDV 235
Query: 191 DAGDKEFQLVIMASGKRIHKEILFPE-PIHAIDQDLGVGATLRYELISGNDR--KLFSLD 247
+ F + + + P + A DQD GV + Y + ++ ++F L+
Sbjct: 236 NDNTPMFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFVKITEKISQIFCLN 295
Query: 248 SVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFE 307
+ G + LD + ++ + L V+A + P +A+V I +LD+NDN+PE
Sbjct: 296 VLTGEISTSANLDYE-----DSSFYELGVEAR--DGPGLRDRAKVLITILDVNDNVPEVV 348
Query: 308 VDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKG-AFSIDPRSG-WLTVRN 365
V + +I E+ P G + D+D G NG T + P+ F ++ G + +
Sbjct: 349 VTSGSRTIAESAPPGTVIALFQVFDRDSGLNGLVTCSI--PRSLPFELEKSVGNYYRLVT 406
Query: 366 QTVLDRE 372
LDRE
Sbjct: 407 NAALDRE 413
Score = 50.0 bits (114), Expect = 6e-05
Identities = 60/220 (27%), Positives = 86/220 (39%), Gaps = 23/220 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I E+ P GT I D DSGLNG + + P +L V Y+
Sbjct: 356 IAESAPPGTVIALFQVFDRDSGLNGLVTCSIPRSL---PFELEKS---VGNYY------- 402
Query: 1000 HVIVARSLPPESEFRLNIS--ALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
++ +L E F NI+ A D G L+ + + V D ND+ P F + Y+ V
Sbjct: 403 RLVTNAALDREEVFLYNITVTATDKGTPPLSTETIISLNVADTNDNPPTFPHSSYSVYVL 462
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTY-----FIQPSDTDLPFEISPLTGVLSVNGELDR 1110
E + V+A D D QNA ++Y +Q + I+ TG+L D
Sbjct: 463 ENNPRGASIFSVNALDPDVDQNAQVSYSLAEDTLQGAPLSSYVSINSDTGILYALRSFDY 522
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
E L V A D+G D NDN+P+
Sbjct: 523 EQLRDLQLWVTASDSG-DPPLSSNVSLSLFVLDQNDNAPE 561
Score = 43.6 bits (98), Expect = 0.006
Identities = 44/169 (26%), Positives = 67/169 (39%), Gaps = 10/169 (5%)
Query: 992 FVINERHGHVIVARSLPPESEFRLNISALDGGNL--NDNIS---VRVFVKDVNDHFPVFK 1046
F +N R+G ++ A + E + L N+ D ++ V V + D+ND+ P F
Sbjct: 75 FSLNPRNGSLVTAGRIDREELCAQSPRCLVSFNILVEDKLNLYPVEVEIVDINDNTPRFL 134
Query: 1047 KTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD---TDLPFEI-SPLTGVL 1102
K + E ++ D D G N+ + + + D+ E P L
Sbjct: 135 KEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSHFSVDVQSEAHGPKYPEL 194
Query: 1103 SVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
+ G LDRE E Y L + A D G DVNDN+P F
Sbjct: 195 VLEGTLDREGEAVYRLVLTAMDGG-DPVRSSVAQILVTVLDVNDNTPMF 242
Score = 40.7 bits (91), Expect = 0.039
Identities = 39/126 (30%), Positives = 62/126 (49%), Gaps = 9/126 (7%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
++S +LFSL+ NGSL +D + L A + V + L K VE+
Sbjct: 66 IVSRGRMQLFSLNPRNGSLVTAGRIDRE---ELCAQSPRCLVSFNILVED-KLNLYPVEV 121
Query: 295 ELLDLNDNLPEFEVDFYNISIVEN-LPNG-FSVLQVMATDKDQGENGEFTYQLDDPKGAF 352
E++D+NDN P F + + I+EN P+ F +++V D D G N ++L F
Sbjct: 122 EIVDINDNTPRFLKEELEVKILENAAPSSRFPLMEVY--DPDVGMNSLQGFKLSG-NSHF 178
Query: 353 SIDPRS 358
S+D +S
Sbjct: 179 SVDVQS 184
Score = 40.7 bits (91), Expect = 0.039
Identities = 39/132 (29%), Positives = 60/132 (45%), Gaps = 13/132 (9%)
Query: 436 DEQLMSFVNVEVTLLDANDNNP-VFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPD 488
D L S V++ + +LD NDN P + P S E + +S A+ G ++ KV AVD D
Sbjct: 539 DPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRS-AEPGYLVTKVVAVDRD 597
Query: 489 LGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPS 546
GQN + Y L + S + F + +TG V A + + + +L V D P
Sbjct: 598 SGQNAWLSYRLLKASEPGL---FSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPL 654
Query: 547 ERRYSLAVVTIE 558
+L V +
Sbjct: 655 SATVTLTVAVAD 666
Score = 38.7 bits (86), Expect = 0.16
Identities = 74/317 (23%), Positives = 121/317 (38%), Gaps = 47/317 (14%)
Query: 1093 FEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY 1152
F ++P G L G +DRE + N D+NDN+P+F
Sbjct: 75 FSLNPRNGSLVTAGRIDREELCAQSPRCLVSFNILVEDKLNLYPVEVEIVDINDNTPRF- 133
Query: 1153 AFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNG 1212
E LE K E S+ ++ VY + N+ G ++ D +G
Sbjct: 134 -LKEELEVKILENAAPSSR----FPLMEVYDPDVGMNSLQGFKLSGNSHFSVDVQSEAHG 188
Query: 1213 -----LILYSLPQRKNQ---------QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFI 1258
L+L R+ + + G P SS A ++VTV DV D M +PV
Sbjct: 189 PKYPELVLEGTLDREGEAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFTQPV-- 246
Query: 1259 SRYYELEIEENVNAPVELVSLNLTEHYENFKMRY-YILNENDTDIRRTFVIDPRNGTLYL 1317
Y + + EN+ ++++ T+ E Y + I + F ++ G +
Sbjct: 247 ---YRVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFVKITEKISQIFCLNVLTGEIST 303
Query: 1318 VRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNS 1377
+ D E YE+ V A R+ P + + KV++ I DVNDN
Sbjct: 304 SANLDYEDSSFYELGVEA------RDGPGL-------------RDRAKVLITILDVNDNV 344
Query: 1378 PK--FTNGNRPLVTAIP 1392
P+ T+G+R + + P
Sbjct: 345 PEVVVTSGSRTIAESAP 361
>AF152316-1|AAD43710.1| 950|Homo sapiens protocadherin alpha 8
protein.
Length = 950
Score = 101 bits (243), Expect = 2e-20
Identities = 137/508 (26%), Positives = 202/508 (39%), Gaps = 88/508 (17%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
++G +F +DRE+ V ++ V + ++D NDNPPVF +
Sbjct: 80 QNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDVNDNPPVFRVKDQK 139
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
F+ E+ + ++ A+DAD G N++ Y L + F +D N S
Sbjct: 140 LFVSESRMPDSRFPLEG---ASDADVGANSVLTYRL--SSHDYFMLDVN---------SK 185
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
+ E K++ LV R + + + + KPE L GT
Sbjct: 186 NDENKLV---ELVLRKSLDREDAPAHHLFLTATDGGKPE-----------------LTGT 225
Query: 914 AGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
++ V N A +Q I EN GTT+IKLNA D D G NG I Y FNS
Sbjct: 226 VQL-LVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSL 284
Query: 974 VYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGGN--LNDNI 1029
V V +F I+ G +++ +L E E +++ I A D G+ + +
Sbjct: 285 V----------ETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHC 334
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
+V V + D ND+ P T + V E V+ + D D G N +T + P
Sbjct: 335 TVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMP--- 391
Query: 1090 DLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+PF+ +S S ++ LDRE Y L V ARD G DVND
Sbjct: 392 HVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGG-SPSLWATASLSVEVADVND 450
Query: 1147 NSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDF 1206
N+P F PE Y ++EN P G + V A D D
Sbjct: 451 NAPAF---------AQPE-----------------YTVFVKENNPPGCHIFTVSARDAD- 483
Query: 1207 IGNGNGLILYSLPQRKNQQNLGLPSLSS 1234
N L+ YSL +R+ +G SLSS
Sbjct: 484 -AQENALVSYSLVERR----VGERSLSS 506
Score = 90.6 bits (215), Expect = 4e-17
Identities = 99/407 (24%), Positives = 168/407 (41%), Gaps = 31/407 (7%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + VT+LD NDN P F S YE + NA GT + K+ A DPD G NG + Y
Sbjct: 221 ELTGTVQLLVTVLDVNDNAPTFEQSE-YEVRIFENADNGTTVIKLNASDPDEGANGAISY 279
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPIL--EGRHALFVEASDQPANPSERRYSLAVV 555
+ F I+ NTG + + + E + + ++A+D+ P ++ V
Sbjct: 280 SFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVR 339
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
++ ++P+ V + GT + I VND + + +
Sbjct: 340 ILD-------KNDNVPEIALTSLSLPVREDAQFGTVIALISVNDL--DSGANGQVTCSLM 390
Query: 616 EGVPF-AVEERSGVITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVND 671
VPF V ++V D L R Y+ A + +L + +V V DVND
Sbjct: 391 PHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVND 450
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLI----ANQQDVT 727
+ ++ +F VKEN+ IF + V + + ++ ++
Sbjct: 451 NAPAFAQPEYT--VF-VKENNPPGC--HIFTVSARDADAQENALVSYSLVERRVGERSLS 505
Query: 728 DDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
I++ E G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 506 SYISVHTESGKVYALQPLDHEELELLQFQVSAR-DAGVPPLGSNVTLQVFVLDENDNAPA 564
Query: 787 FEHATYEGFIMENSK-IGTEIKMDNI---IKATDADEGTNALFMYTL 829
G SK + + ++ ++A DAD G NA Y L
Sbjct: 565 LLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYEL 611
Score = 79.8 bits (188), Expect = 7e-14
Identities = 112/477 (23%), Positives = 189/477 (39%), Gaps = 34/477 (7%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +V+V + D NDN PVF + F +S + A D D+G
Sbjct: 105 HLEVIVDRPLQVFHVDVEVKDVNDNPPVFRVKDQKLFVSESRMP-DSRFPLEGASDADVG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE---GRHALFVEASDQPANPSE 547
N ++ Y L + K + N V + H LF+ A+D
Sbjct: 164 ANSVLTYRLSSHDYFMLDVNSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELT 223
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QND 605
L V ++V + P F + YE + N GT+V ++ +D E
Sbjct: 224 GTVQLLVTVLDV-------NDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGA 276
Query: 606 VSYDLLHGYEEGV--PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNAT 663
+SY E V F+++ +G I + +L +Y + + + + + T
Sbjct: 277 ISYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKI-LIDATDKGHPPMAGHCT 335
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIAN 722
V +V + D+ + + A + + V+E++ G I I +++ + G V +
Sbjct: 336 V-LVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALI---SVNDLDSGANGQVTCSLMP 391
Query: 723 QQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEND 782
++ LDRE+ Y + V A + G S +++ + D ND
Sbjct: 392 HVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTAR-DGGSPSLWATASLSVEVADVND 450
Query: 783 NPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEG--KEM 836
N P F Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 451 NAPAFAQPEYTVFVKENNPPGCHI---FTVSARDADAQENALVSYSLVERRVGERSLSSY 507
Query: 837 FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 508 ISVHTESGKV-YALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAP 563
Score = 70.1 bits (164), Expect = 6e-11
Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 16/163 (9%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGS-----LFLEKELDLDAEHNLQANTFVL 274
A D D+G + L Y L S +D + ++S N L L K LD + A L
Sbjct: 157 ASDADVGANSVLTYRL-SSHDYFMLDVNSKNDENKLVELVLRKSLDRE-----DAPAHHL 210
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A+ P T ++ + +LD+NDN P FE Y + I EN NG +V+++ A+D D
Sbjct: 211 FLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPD 270
Query: 335 QGENGEFTYQLDDPKGA-----FSIDPRSGWLTVRNQTVLDRE 372
+G NG +Y + FSID +G + +R ++E
Sbjct: 271 EGANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQE 313
Score = 65.3 bits (152), Expect = 2e-09
Identities = 65/237 (27%), Positives = 103/237 (43%), Gaps = 10/237 (4%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
V V+DVND + + IF +N G + ++ ++ NG + F +
Sbjct: 230 VTVLDVNDNAPTFEQSEYEVRIFENADN--GTTVIKLNASDPDE-GANGAISYSFNSLVE 286
Query: 724 QDVTDDIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEND 782
V D +I + G I + LD E+ ++Y++ + A +KG AG V + I D+ND
Sbjct: 287 TMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDAT-DKGHPPMAGHCTVLVRILDKND 345
Query: 783 NPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDEN 842
N P + + E+++ GT I + I D D G N +L
Sbjct: 346 NVPEIALTSLSLPVREDAQFGTVIAL---ISVNDLDSGANGQVTCSLMPHVPFKLVSTFK 402
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTGGLS--SEAELIIMIGDENDNKPEFNQIE 897
+ +LDRE+ Y+L + ARD G S + A L + + D NDN P F Q E
Sbjct: 403 NYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPE 459
Score = 64.9 bits (151), Expect = 2e-09
Identities = 63/221 (28%), Positives = 94/221 (42%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y E +
Sbjct: 443 VEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL-VERRVGE 501
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVF 1034
LS+ Y ++ G V + L E + +SA D G L N++++VF
Sbjct: 502 RSLSS-------YISVHTESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVF 554
Query: 1035 VKDVNDHFPVFKKTWYNFN-------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQP- 1086
V D ND+ P + V + V+ KV A DAD G NA L+Y +QP
Sbjct: 555 VLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPA 614
Query: 1087 -SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
S +PF + TG +S LD ++ L V+ +D+G
Sbjct: 615 ASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHG 655
Score = 60.9 bits (141), Expect = 3e-08
Identities = 67/277 (24%), Positives = 113/277 (40%), Gaps = 25/277 (9%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKL---FSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
++A D D G + Y S + + FS+D G + + LD + E N + +
Sbjct: 264 LNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQE-----NLYKI 318
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A+ +P V + +LD NDN+PE + ++ + E+ G + + D D
Sbjct: 319 LIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLD 378
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
G NG+ T L + + ++ + LDRE S+ + V A++ +PS+ T
Sbjct: 379 SGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWAT 438
Query: 394 FADSQRIAKWRRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDAN 453
+ S +A + NAP + P+ EN + V DA
Sbjct: 439 ASLSVEVA-----DVNDNAP----AFAQPEYTVFVKEN----NPPGCHIFTVSARDADAQ 485
Query: 454 DNNPV---FVPSNLYEFSMKSNAKVGTVIGKVKAVDP 487
+N V V + E S+ S V T GKV A+ P
Sbjct: 486 ENALVSYSLVERRVGERSLSSYISVHTESGKVYALQP 522
Score = 59.7 bits (138), Expect = 8e-08
Identities = 70/293 (23%), Positives = 119/293 (40%), Gaps = 24/293 (8%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPI-- 124
L G +++ + + V + DVNDN P F + Y V + E G +
Sbjct: 212 LTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDE 271
Query: 125 GPSLTIPLTVPRGL-TIFKDIRAFDRDKPNT--------PNSDVHYSIVSGNDDGHFALE 175
G + I + + T+ D + DR+ +++ ++ D GH +
Sbjct: 272 GANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPM- 330
Query: 176 SSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI---DQDLGVGATLR 232
+ H VL+ ++LD + D ++ + + + ++ F I I D D G +
Sbjct: 331 AGHCTVLV--RILDKN--DNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVT 386
Query: 233 YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV 292
L+ KL S SL L+ LD + + + + L V A +P A A +
Sbjct: 387 CSLMPHVPFKLVSTFKNYYSLVLDSALDRE-----RVSAYELVVTARDGGSPSLWATASL 441
Query: 293 EIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+E+ D+NDN P F Y + + EN P G + V A D D EN +Y L
Sbjct: 442 SVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL 494
Score = 54.0 bits (124), Expect = 4e-06
Identities = 67/241 (27%), Positives = 101/241 (41%), Gaps = 23/241 (9%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
++ + KN ++ + E+ GT I ++ DLDSG NGQ+ V
Sbjct: 337 LVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHV--- 393
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN--LNDNISVRV 1033
P KL + K Y+ + ++ +L E S + L ++A DGG+ L S+ V
Sbjct: 394 PFKLVST---FKNYYSL-------VLDSALDRERVSAYELVVTARDGGSPSLWATASLSV 443
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTD 1090
V DVND+ P F + Y V+E + V A DAD +NA ++Y + + +
Sbjct: 444 EVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERS 503
Query: 1091 LPFEISPLT--GVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
L IS T G + LD E + V ARD G D NDN+
Sbjct: 504 LSSYISVHTESGKVYALQPLDHEELELLQFQVSARDAG-VPPLGSNVTLQVFVLDENDNA 562
Query: 1149 P 1149
P
Sbjct: 563 P 563
Score = 44.0 bits (99), Expect = 0.004
Identities = 32/110 (29%), Positives = 54/110 (49%), Gaps = 7/110 (6%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L+VTV DV D + P F YE+ I EN + ++ LN ++ E
Sbjct: 218 GKPELTGTVQLLVTVLDVND-----NAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
N + Y + +T + F ID G + + + D E ++ Y++++ A
Sbjct: 273 ANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDA 322
Score = 43.2 bits (97), Expect = 0.007
Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 9/110 (8%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKV------GTVIGKVKAVDPDLGQN 492
L S V ++V +LD NDN P + + ++ V G V+ KV+AVD D G N
Sbjct: 545 LGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYN 604
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAE--SPILEGRHALFVEASD 540
+ Y+LQ ++ + PF++ TG +S RH L V D
Sbjct: 605 AWLSYELQPAAS-SPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKD 653
Score = 40.3 bits (90), Expect = 0.052
Identities = 40/131 (30%), Positives = 64/131 (48%), Gaps = 12/131 (9%)
Query: 221 IDQDLGVG-ATL---RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQ 275
I QDLG+ A L + + S R L + NG LF+ +D + A + L+
Sbjct: 48 IAQDLGLELAELVPRLFRVASKRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLE 107
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVEN-LPNGFSVLQVMATDKD 334
V ++ PL+ V++E+ D+NDN P F V + + E+ +P+ L+ A+D D
Sbjct: 108 VI---VDRPLQVFH--VDVEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLE-GASDAD 161
Query: 335 QGENGEFTYQL 345
G N TY+L
Sbjct: 162 VGANSVLTYRL 172
Score = 35.9 bits (79), Expect = 1.1
Identities = 51/191 (26%), Positives = 77/191 (40%), Gaps = 20/191 (10%)
Query: 218 IHAIDQDLGVGATLRYELISGN--DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTF 272
+ A D D A + Y L+ +R L S SV+ G ++ + LD + LQ
Sbjct: 477 VSARDADAQENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEELELLQ---- 532
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLP---EFEVDFYNISIVENLPN----GFSV 325
QV A P + +++ +LD NDN P E V + + +P G V
Sbjct: 533 -FQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVV 591
Query: 326 LQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLT--VRNQTVLDREAHSSLRMKVYA 383
+V A D D G N +Y+L + I R G T + VLD R+ V
Sbjct: 592 AKVRAVDADSGYNAWLSYELQPAASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLV 651
Query: 384 KE-TNPSVVGT 393
K+ P++ T
Sbjct: 652 KDHGEPALTAT 662
>AC005609-6|AAC34318.1| 814|Homo sapiens KIAA0345-like 6 protein.
Length = 814
Score = 101 bits (243), Expect = 2e-20
Identities = 137/508 (26%), Positives = 202/508 (39%), Gaps = 88/508 (17%)
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
++G +F +DRE+ V ++ V + ++D NDNPPVF +
Sbjct: 80 QNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDVNDNPPVFRVKDQK 139
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSL 853
F+ E+ + ++ A+DAD G N++ Y L + F +D N S
Sbjct: 140 LFVSESRMPDSRFPLEG---ASDADVGANSVLTYRL--SSHDYFMLDVN---------SK 185
Query: 854 DREKKIMYKLSLVARDTGGLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLNGT 913
+ E K++ LV R + + + + KPE L GT
Sbjct: 186 NDENKLV---ELVLRKSLDREDAPAHHLFLTATDGGKPE-----------------LTGT 225
Query: 914 AGFTIIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSE 973
++ V N A +Q I EN GTT+IKLNA D D G NG I Y FNS
Sbjct: 226 VQL-LVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSL 284
Query: 974 VYIPPSKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGGN--LNDNI 1029
V V +F I+ G +++ +L E E +++ I A D G+ + +
Sbjct: 285 V----------ETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHC 334
Query: 1030 SVRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDT 1089
+V V + D ND+ P T + V E V+ + D D G N +T + P
Sbjct: 335 TVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMP--- 391
Query: 1090 DLPFE-ISPLTGVLS--VNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVND 1146
+PF+ +S S ++ LDRE Y L V ARD G DVND
Sbjct: 392 HVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGG-SPSLWATASLSVEVADVND 450
Query: 1147 NSPKFYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDF 1206
N+P F PE Y ++EN P G + V A D D
Sbjct: 451 NAPAF---------AQPE-----------------YTVFVKENNPPGCHIFTVSARDAD- 483
Query: 1207 IGNGNGLILYSLPQRKNQQNLGLPSLSS 1234
N L+ YSL +R+ +G SLSS
Sbjct: 484 -AQENALVSYSLVERR----VGERSLSS 506
Score = 90.6 bits (215), Expect = 4e-17
Identities = 99/407 (24%), Positives = 168/407 (41%), Gaps = 31/407 (7%)
Query: 438 QLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLY 497
+L V + VT+LD NDN P F S YE + NA GT + K+ A DPD G NG + Y
Sbjct: 221 ELTGTVQLLVTVLDVNDNAPTFEQSE-YEVRIFENADNGTTVIKLNASDPDEGANGAISY 279
Query: 498 DLQRTSNLTITSPFKINPNTGTVSVAESPIL--EGRHALFVEASDQPANPSERRYSLAVV 555
+ F I+ NTG + + + E + + ++A+D+ P ++ V
Sbjct: 280 SFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVR 339
Query: 556 TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYE 615
++ ++P+ V + GT + I VND + + +
Sbjct: 340 ILD-------KNDNVPEIALTSLSLPVREDAQFGTVIALISVNDL--DSGANGQVTCSLM 390
Query: 616 EGVPF-AVEERSGVITVVDD--LSRYNRPMYDFEAVALQENA-NLSIVTNATVHVVDVND 671
VPF V ++V D L R Y+ A + +L + +V V DVND
Sbjct: 391 PHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVND 450
Query: 672 ERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLI----ANQQDVT 727
+ ++ +F VKEN+ IF + V + + ++ ++
Sbjct: 451 NAPAFAQPEYT--VF-VKENNPPGC--HIFTVSARDADAQENALVSYSLVERRVGERSLS 505
Query: 728 DDIAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPV 786
I++ E G ++ +PLD E+ ++ + V A + GV + +++ DENDN P
Sbjct: 506 SYISVHTESGKVYALQPLDHEELELLQFQVSAR-DAGVPPLGSNVTLQVFVLDENDNAPA 564
Query: 787 FEHATYEGFIMENSK-IGTEIKMDNI---IKATDADEGTNALFMYTL 829
G SK + + ++ ++A DAD G NA Y L
Sbjct: 565 LLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYEL 611
Score = 79.8 bits (188), Expect = 7e-14
Identities = 112/477 (23%), Positives = 189/477 (39%), Gaps = 34/477 (7%)
Query: 431 NIEYYDEQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLG 490
++E ++ + +V+V + D NDN PVF + F +S + A D D+G
Sbjct: 105 HLEVIVDRPLQVFHVDVEVKDVNDNPPVFRVKDQKLFVSESRMP-DSRFPLEGASDADVG 163
Query: 491 QNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE---GRHALFVEASDQPANPSE 547
N ++ Y L + K + N V + H LF+ A+D
Sbjct: 164 ANSVLTYRLSSHDYFMLDVNSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELT 223
Query: 548 RRYSLAVVTIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QND 605
L V ++V + P F + YE + N GT+V ++ +D E
Sbjct: 224 GTVQLLVTVLDV-------NDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGA 276
Query: 606 VSYDLLHGYEEGV--PFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNAT 663
+SY E V F+++ +G I + +L +Y + + + + + T
Sbjct: 277 ISYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKI-LIDATDKGHPPMAGHCT 335
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSA-GAAIGQIFHTNMSSIYGNGTGNVRFLIAN 722
V +V + D+ + + A + + V+E++ G I I +++ + G V +
Sbjct: 336 V-LVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALI---SVNDLDSGANGQVTCSLMP 391
Query: 723 QQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEND 782
++ LDRE+ Y + V A + G S +++ + D ND
Sbjct: 392 HVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTAR-DGGSPSLWATASLSVEVADVND 450
Query: 783 NPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTL----FGEG--KEM 836
N P F Y F+ EN+ G I + A DAD NAL Y+L GE
Sbjct: 451 NAPAFAQPEYTVFVKENNPPGCHI---FTVSARDADAQENALVSYSLVERRVGERSLSSY 507
Query: 837 FDVDENTGVVKFIGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
V +G V + LD E+ + + + ARD G L S L + + DENDN P
Sbjct: 508 ISVHTESGKV-YALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAP 563
Score = 70.1 bits (164), Expect = 6e-11
Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 16/163 (9%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLDSVNGS-----LFLEKELDLDAEHNLQANTFVL 274
A D D+G + L Y L S +D + ++S N L L K LD + A L
Sbjct: 157 ASDADVGANSVLTYRL-SSHDYFMLDVNSKNDENKLVELVLRKSLDRE-----DAPAHHL 210
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A+ P T ++ + +LD+NDN P FE Y + I EN NG +V+++ A+D D
Sbjct: 211 FLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPD 270
Query: 335 QGENGEFTYQLDDPKGA-----FSIDPRSGWLTVRNQTVLDRE 372
+G NG +Y + FSID +G + +R ++E
Sbjct: 271 EGANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQE 313
Score = 65.3 bits (152), Expect = 2e-09
Identities = 65/237 (27%), Positives = 103/237 (43%), Gaps = 10/237 (4%)
Query: 664 VHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQ 723
V V+DVND + + IF +N G + ++ ++ NG + F +
Sbjct: 230 VTVLDVNDNAPTFEQSEYEVRIFENADN--GTTVIKLNASDPDE-GANGAISYSFNSLVE 286
Query: 724 QDVTDDIAIAED-GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDEND 782
V D +I + G I + LD E+ ++Y++ + A +KG AG V + I D+ND
Sbjct: 287 TMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDAT-DKGHPPMAGHCTVLVRILDKND 345
Query: 783 NPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDEN 842
N P + + E+++ GT I + I D D G N +L
Sbjct: 346 NVPEIALTSLSLPVREDAQFGTVIAL---ISVNDLDSGANGQVTCSLMPHVPFKLVSTFK 402
Query: 843 TGVVKFIGDSLDREKKIMYKLSLVARDTGGLS--SEAELIIMIGDENDNKPEFNQIE 897
+ +LDRE+ Y+L + ARD G S + A L + + D NDN P F Q E
Sbjct: 403 NYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPE 459
Score = 64.9 bits (151), Expect = 2e-09
Identities = 63/221 (28%), Positives = 94/221 (42%), Gaps = 21/221 (9%)
Query: 919 IEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPP 978
+EV N A Q + EN P G I ++A D D+ N + Y E +
Sbjct: 443 VEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL-VERRVGE 501
Query: 979 SKLSADALEVKRYFVINERHGHVIVARSLPPESE--FRLNISALDGG--NLNDNISVRVF 1034
LS+ Y ++ G V + L E + +SA D G L N++++VF
Sbjct: 502 RSLSS-------YISVHTESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVF 554
Query: 1035 VKDVNDHFPVFKKTWYNFN-------VEEAQYTRRVLGKVDATDADFGQNANLTYFIQP- 1086
V D ND+ P + V + V+ KV A DAD G NA L+Y +QP
Sbjct: 555 VLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPA 614
Query: 1087 -SDTDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDNG 1126
S +PF + TG +S LD ++ L V+ +D+G
Sbjct: 615 ASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHG 655
Score = 60.9 bits (141), Expect = 3e-08
Identities = 67/277 (24%), Positives = 113/277 (40%), Gaps = 25/277 (9%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKL---FSLDSVNGSLFLEKELDLDAEHNLQANTFVL 274
++A D D G + Y S + + FS+D G + + LD + E N + +
Sbjct: 264 LNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQE-----NLYKI 318
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A+ +P V + +LD NDN+PE + ++ + E+ G + + D D
Sbjct: 319 LIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLD 378
Query: 335 QGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGT 393
G NG+ T L + + ++ + LDRE S+ + V A++ +PS+ T
Sbjct: 379 SGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWAT 438
Query: 394 FADSQRIAKWRRQPLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVTLLDAN 453
+ S +A + NAP + P+ EN + V DA
Sbjct: 439 ASLSVEVA-----DVNDNAP----AFAQPEYTVFVKEN----NPPGCHIFTVSARDADAQ 485
Query: 454 DNNPV---FVPSNLYEFSMKSNAKVGTVIGKVKAVDP 487
+N V V + E S+ S V T GKV A+ P
Sbjct: 486 ENALVSYSLVERRVGERSLSSYISVHTESGKVYALQP 522
Score = 59.7 bits (138), Expect = 8e-08
Identities = 70/293 (23%), Positives = 119/293 (40%), Gaps = 24/293 (8%)
Query: 67 LVRIGAGLNQISAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPI-- 124
L G +++ + + V + DVNDN P F + Y V + E G +
Sbjct: 212 LTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDE 271
Query: 125 GPSLTIPLTVPRGL-TIFKDIRAFDRDKPNT--------PNSDVHYSIVSGNDDGHFALE 175
G + I + + T+ D + DR+ +++ ++ D GH +
Sbjct: 272 GANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPM- 330
Query: 176 SSHKPVLLLRKVLDYDAGDKEFQLVIMASGKRIHKEILFPEPIHAI---DQDLGVGATLR 232
+ H VL+ ++LD + D ++ + + + ++ F I I D D G +
Sbjct: 331 AGHCTVLV--RILDKN--DNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVT 386
Query: 233 YELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARV 292
L+ KL S SL L+ LD + + + + L V A +P A A +
Sbjct: 387 CSLMPHVPFKLVSTFKNYYSLVLDSALDRE-----RVSAYELVVTARDGGSPSLWATASL 441
Query: 293 EIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL 345
+E+ D+NDN P F Y + + EN P G + V A D D EN +Y L
Sbjct: 442 SVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL 494
Score = 54.0 bits (124), Expect = 4e-06
Identities = 67/241 (27%), Positives = 101/241 (41%), Gaps = 23/241 (9%)
Query: 918 IIEVKPKNKFALDVDQLGPLFLIPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIP 977
++ + KN ++ + E+ GT I ++ DLDSG NGQ+ V
Sbjct: 337 LVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHV--- 393
Query: 978 PSKLSADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN--LNDNISVRV 1033
P KL + K Y+ + ++ +L E S + L ++A DGG+ L S+ V
Sbjct: 394 PFKLVST---FKNYYSL-------VLDSALDRERVSAYELVVTARDGGSPSLWATASLSV 443
Query: 1034 FVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFI---QPSDTD 1090
V DVND+ P F + Y V+E + V A DAD +NA ++Y + + +
Sbjct: 444 EVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERS 503
Query: 1091 LPFEISPLT--GVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNS 1148
L IS T G + LD E + V ARD G D NDN+
Sbjct: 504 LSSYISVHTESGKVYALQPLDHEELELLQFQVSARDAG-VPPLGSNVTLQVFVLDENDNA 562
Query: 1149 P 1149
P
Sbjct: 563 P 563
Score = 44.0 bits (99), Expect = 0.004
Identities = 32/110 (29%), Positives = 54/110 (49%), Gaps = 7/110 (6%)
Query: 1228 GLPSLSSTAILMVTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEHYE- 1286
G P L+ T L+VTV DV D + P F YE+ I EN + ++ LN ++ E
Sbjct: 218 GKPELTGTVQLLVTVLDVND-----NAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEG 272
Query: 1287 -NFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRSPDREVKDTYEVIVRA 1335
N + Y + +T + F ID G + + + D E ++ Y++++ A
Sbjct: 273 ANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDA 322
Score = 43.2 bits (97), Expect = 0.007
Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 9/110 (8%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKV------GTVIGKVKAVDPDLGQN 492
L S V ++V +LD NDN P + + ++ V G V+ KV+AVD D G N
Sbjct: 545 LGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYN 604
Query: 493 GMVLYDLQRTSNLTITSPFKINPNTGTVSVAE--SPILEGRHALFVEASD 540
+ Y+LQ ++ + PF++ TG +S RH L V D
Sbjct: 605 AWLSYELQPAAS-SPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKD 653
Score = 40.3 bits (90), Expect = 0.052
Identities = 40/131 (30%), Positives = 64/131 (48%), Gaps = 12/131 (9%)
Query: 221 IDQDLGVG-ATL---RYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFV-LQ 275
I QDLG+ A L + + S R L + NG LF+ +D + A + L+
Sbjct: 48 IAQDLGLELAELVPRLFRVASKRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLE 107
Query: 276 VQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVEN-LPNGFSVLQVMATDKD 334
V ++ PL+ V++E+ D+NDN P F V + + E+ +P+ L+ A+D D
Sbjct: 108 VI---VDRPLQVFH--VDVEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLE-GASDAD 161
Query: 335 QGENGEFTYQL 345
G N TY+L
Sbjct: 162 VGANSVLTYRL 172
Score = 35.9 bits (79), Expect = 1.1
Identities = 51/191 (26%), Positives = 77/191 (40%), Gaps = 20/191 (10%)
Query: 218 IHAIDQDLGVGATLRYELISGN--DRKLFSLDSVN---GSLFLEKELDLDAEHNLQANTF 272
+ A D D A + Y L+ +R L S SV+ G ++ + LD + LQ
Sbjct: 477 VSARDADAQENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEELELLQ---- 532
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLP---EFEVDFYNISIVENLPN----GFSV 325
QV A P + +++ +LD NDN P E V + + +P G V
Sbjct: 533 -FQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVV 591
Query: 326 LQVMATDKDQGENGEFTYQLDDPKGAFSIDPRSGWLT--VRNQTVLDREAHSSLRMKVYA 383
+V A D D G N +Y+L + I R G T + VLD R+ V
Sbjct: 592 AKVRAVDADSGYNAWLSYELQPAASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLV 651
Query: 384 KE-TNPSVVGT 393
K+ P++ T
Sbjct: 652 KDHGEPALTAT 662
>AB209178-1|BAD92415.1| 950|Homo sapiens protocadherin gamma
subfamily A, 6 isoform 1 precursor variant protein.
Length = 950
Score = 101 bits (243), Expect = 2e-20
Identities = 112/467 (23%), Positives = 194/467 (41%), Gaps = 27/467 (5%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVL 496
E ++ VEV ++D NDN P F+ L E + NA + ++ DPD+G N +
Sbjct: 129 EDKLNLYPVEVEIVDINDNTPRFLKEEL-EVKILENAAPSSRFPLMEVYDPDVGMNSLQG 187
Query: 497 YDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVT 556
+ L S+ ++ + + V E + A++ R S+A +
Sbjct: 188 FKLSGNSHFSVDVQSEAHGPKYPELVLEGTLDREGEAVYRLVLTAMDGGDPVRSSVAQIL 247
Query: 557 IEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFE--QNDVSYDLLHGY 614
+ V + P F Y V N+ +GT V + D E +V+Y +
Sbjct: 248 VTVL----DVNDNTPMFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFVKIT 303
Query: 615 EE-GVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVNDER 673
E+ F + +G I+ +L + Y+ V ++ L + ++DVND
Sbjct: 304 EKISQIFCLNVLTGEISTSANLDYEDSSFYEL-GVEARDGPGLRDRAKVLITILDVNDNV 362
Query: 674 GVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDDIAIA 733
++ + S I A+ Q+F + G V I + ++
Sbjct: 363 PEVVVTSGSRTIAESAPPGTVIALFQVFDRDSGL-----NGLVTCSIPRSLPFELEKSVG 417
Query: 734 EDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYE 793
+ T LDRE+ +Y +TV A +KG + +++ + D NDNPP F H++Y
Sbjct: 418 NYYRLVTNAALDREEVFLYNITVTAT-DKGTPPLSTETIISLNVADTNDNPPTFPHSSYS 476
Query: 794 GFIMENSKIGTEIKMDNIIKATDADEGTNALFMY-----TLFGEGKEMF-DVDENTGVVK 847
+++EN+ G I + A D D NA Y TL G + ++ +TG++
Sbjct: 477 VYVLENNPRGASIFS---VNALDPDVDQNAQVSYSLAEDTLQGAPLSSYVSINSDTGIL- 532
Query: 848 FIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPE 892
+ S D E+ +L + A D+G LSS L + + D+NDN PE
Sbjct: 533 YALRSFDYEQLRDLQLWVTASDSGDPPLSSNVSLSLFVLDQNDNAPE 579
Score = 86.2 bits (204), Expect = 8e-16
Identities = 70/235 (29%), Positives = 103/235 (43%), Gaps = 27/235 (11%)
Query: 929 LDVDQLGPLFL-------IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LDV+ P+F +PEN+P+GT ++ + A D D G++G++ Y F K+
Sbjct: 251 LDVNDNTPMFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSF--------VKI 302
Query: 982 SADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGNLNDNISVRVFVKDVN 1039
+ ++ + F +N G + + +L E S + L + A DG L D V + + DVN
Sbjct: 303 TE---KISQIFCLNVLTGEISTSANLDYEDSSFYELGVEARDGPGLRDRAKVLITILDVN 359
Query: 1040 DHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLT 1099
D+ P T + + E+ V+ D D G N +T I S LPFE+
Sbjct: 360 DNVPEVVVTSGSRTIAESAPPGTVIALFQVFDRDSGLNGLVTCSIPRS---LPFELEKSV 416
Query: 1100 G---VLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
G L N LDRE Y +TV A D G D NDN P F
Sbjct: 417 GNYYRLVTNAALDREEVFLYNITVTATDKG-TPPLSTETIISLNVADTNDNPPTF 470
Score = 71.3 bits (167), Expect = 2e-11
Identities = 44/125 (35%), Positives = 72/125 (57%), Gaps = 7/125 (5%)
Query: 222 DQDLGVGATLRYELISGNDRKLFSLD---SVNGSLFLEKELDLDAEHNLQANTFVLQVQA 278
D D+G+ + ++L SGN FS+D +G + E L+ + +A + L + A
Sbjct: 177 DPDVGMNSLQGFKL-SGNSH--FSVDVQSEAHGPKYPELVLEGTLDREGEA-VYRLVLTA 232
Query: 279 SQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKDQGEN 338
+P++++ A++ + +LD+NDN P F Y +S+ ENLP G VL V ATD+D+G +
Sbjct: 233 MDGGDPVRSSVAQILVTVLDVNDNTPMFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVH 292
Query: 339 GEFTY 343
GE TY
Sbjct: 293 GEVTY 297
Score = 68.9 bits (161), Expect = 1e-10
Identities = 51/167 (30%), Positives = 78/167 (46%), Gaps = 9/167 (5%)
Query: 735 DGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEG 794
+G++ T +DRE+ + FN V +Y V + I D NDN P F E
Sbjct: 99 NGSLVTAGRIDREELCAQSPRCLVSFNILVEDKLNLYPVEVEIVDINDNTPRFLKEELEV 158
Query: 795 FIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF----IG 850
I+EN+ + +++ D D G N+L + L G DV K+ +
Sbjct: 159 KILENAAPSSRFP---LMEVYDPDVGMNSLQGFKLSGNSHFSVDVQSEAHGPKYPELVLE 215
Query: 851 DSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQ 895
+LDRE + +Y+L L A D G SS A++++ + D NDN P F Q
Sbjct: 216 GTLDREGEAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFTQ 262
Score = 65.3 bits (152), Expect = 2e-09
Identities = 78/300 (26%), Positives = 122/300 (40%), Gaps = 21/300 (7%)
Query: 78 SAYLSVTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLTIPLTVPRG 137
S+ + V + DVNDN P+F Y V+V E P G + +T
Sbjct: 241 SSVAQILVTVLDVNDNTPMFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFV 300
Query: 138 LTIFKDIRAFDRDKPNTPNSDVHYSIVSGNDDGHF---ALESSHKPVLLLR-KVLD--YD 191
K + F N ++ S +D F +E+ P L R KVL D
Sbjct: 301 KITEKISQIFCL---NVLTGEISTSANLDYEDSSFYELGVEARDGPGLRDRAKVLITILD 357
Query: 192 AGDKEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYELISGNDRKL-FSLDSVN 250
D ++V+ SG R E P + A+ Q + L + R L F L+
Sbjct: 358 VNDNVPEVVV-TSGSRTIAESAPPGTVIALFQVFDRDSGLNGLVTCSIPRSLPFELEKSV 416
Query: 251 GSLF-LEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVD 309
G+ + L LD E N + V A+ P + + + + + D NDN P F
Sbjct: 417 GNYYRLVTNAALDREEVFLYN---ITVTATDKGTPPLSTETIISLNVADTNDNPPTFPHS 473
Query: 310 FYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGWLTVRNQT 367
Y++ ++EN P G S+ V A D D +N + +Y L D +GA P S ++++ + T
Sbjct: 474 SYSVYVLENNPRGASIFSVNALDPDVDQNAQVSYSLAEDTLQGA----PLSSYVSINSDT 529
Score = 64.5 bits (150), Expect = 3e-09
Identities = 82/329 (24%), Positives = 141/329 (42%), Gaps = 24/329 (7%)
Query: 1010 ESEFRLNISALDGGN-LNDNIS-VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKV 1067
E+ +RL ++A+DGG+ + +++ + V V DVND+ P+F + Y +V E + V
Sbjct: 223 EAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFTQPVYRVSVPENLPVGTPVLAV 282
Query: 1068 DATDADFGQNANLTY-FIQPSD-TDLPFEISPLTGVLSVNGELDRETEDKYILTVVARDN 1125
ATD D G + +TY F++ ++ F ++ LTG +S + LD E Y L V ARD
Sbjct: 283 TATDQDEGVHGEVTYSFVKITEKISQIFCLNVLTGEISTSANLDYEDSSFYELGVEARDG 342
Query: 1126 GXXXXXXXXXXXXXXXXDVNDNSPKFYAFD---ELLEWKHPEADELSNHNFE-SVMMIPV 1181
DVNDN P+ + E P F+ + +
Sbjct: 343 ---PGLRDRAKVLITILDVNDNVPEVVVTSGSRTIAESAPPGTVIALFQVFDRDSGLNGL 399
Query: 1182 YKATIEENAP--IGTTVAKVFANDTDFIGNGNGLILYSLPQRKNQQNLGLPSLSSTAILM 1239
+I + P + +V + T+ + + LY++ + G P LS+ I+
Sbjct: 400 VTCSIPRSLPFELEKSVGNYYRLVTNAALDREEVFLYNITVTATDK--GTPPLSTETIIS 457
Query: 1240 VTVADVPDEVEMSDKPVFISRYYELEIEENVNAPVELVSLNLTEH--YENFKMRYYILNE 1297
+ VAD D + P F Y + + EN + S+N + +N ++ Y + +
Sbjct: 458 LNVADTND-----NPPTFPHSSYSVYVLENNPRGASIFSVNALDPDVDQNAQVSYSLAED 512
Query: 1298 --NDTDIRRTFVIDPRNGTLYLVRSPDRE 1324
+ I+ G LY +RS D E
Sbjct: 513 TLQGAPLSSYVSINSDTGILYALRSFDYE 541
Score = 58.4 bits (135), Expect = 2e-07
Identities = 63/197 (31%), Positives = 92/197 (46%), Gaps = 21/197 (10%)
Query: 942 ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHGHV 1001
EN P G +I +NALD D N Q+ Y +E + + LS+ Y IN G +
Sbjct: 481 ENNPRGASIFSVNALDPDVDQNAQVSYSL-AEDTLQGAPLSS-------YVSINSDTGIL 532
Query: 1002 IVARSLPPES--EFRLNISALDGGN--LNDNISVRVFVKDVNDHFPVF----KKTWYNFN 1053
RS E + +L ++A D G+ L+ N+S+ +FV D ND+ P T +
Sbjct: 533 YALRSFDYEQLRDLQLWVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTG 592
Query: 1054 VEEAQYTRR---VLGKVDATDADFGQNANLTYFIQPSDTDLPFEISPLTG-VLSVNGELD 1109
VE A + ++ KV A D D GQNA L+Y + + F + TG V LD
Sbjct: 593 VELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRMARALLD 652
Query: 1110 RETEDKYILTVVARDNG 1126
R+ K L V +D+G
Sbjct: 653 RDAL-KQSLVVAVQDHG 668
Score = 55.2 bits (127), Expect = 2e-06
Identities = 61/232 (26%), Positives = 104/232 (44%), Gaps = 22/232 (9%)
Query: 736 GTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGF 795
G I T LD E Y + V A G+ A +V I I D NDN P +
Sbjct: 317 GEISTSANLDYEDSSFYELGVEARDGPGLRDRA---KVLITILDVNDNVPEVVVTSGSRT 373
Query: 796 IMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTG-VVKFIGDS-L 853
I E++ GT I + + D D G N L ++ F+++++ G + + ++ L
Sbjct: 374 IAESAPPGTVIALFQVF---DRDSGLNGLVTCSI--PRSLPFELEKSVGNYYRLVTNAAL 428
Query: 854 DREKKIMYKLSLVARDTGG--LSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN 911
DRE+ +Y +++ A D G LS+E + + + D NDN P F + V E
Sbjct: 429 DREEVFLYNITVTATDKGTPPLSTETIISLNVADTNDNPPTFPHSSYSVYV---LENNPR 485
Query: 912 GTAGFTIIEVKPKNKFALDVDQLGPL-FLIPENIPIGTTIIKLNALDLDSGL 962
G + F++ + P DVDQ + + + E+ G + +++ D+G+
Sbjct: 486 GASIFSVNALDP------DVDQNAQVSYSLAEDTLQGAPLSSYVSINSDTGI 531
Score = 54.8 bits (126), Expect = 2e-06
Identities = 79/313 (25%), Positives = 132/313 (42%), Gaps = 30/313 (9%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTVDELTPTGEKAFIFLIAPIGPSLT--IPLTVPRGLT- 139
V + I DVNDNVP + T T+ E P G +F + L + ++PR L
Sbjct: 351 VLITILDVNDNVPEVVVTSGSRTIAESAPPGTVIALFQVFDRDSGLNGLVTCSIPRSLPF 410
Query: 140 -IFKDIRAFDRDKPNTP--NSDVH-YSI-VSGNDDGHFALESSHKPVLLLRKVLDYDAGD 194
+ K + + R N +V Y+I V+ D G L + L + D
Sbjct: 411 ELEKSVGNYYRLVTNAALDREEVFLYNITVTATDKGTPPLSTETIISLNVADTNDNPPTF 470
Query: 195 KEFQLVIMASGKRIHKEILFPEPIHAIDQDLGVGATLRYEL----ISGNDRKLF-SLDSV 249
+ +F ++A+D D+ A + Y L + G + S++S
Sbjct: 471 PHSSYSVYVLENNPRGASIFS--VNALDPDVDQNAQVSYSLAEDTLQGAPLSSYVSINSD 528
Query: 250 NGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEF--- 306
G L+ + D + +LQ L V AS +P ++ + + +LD NDN PE
Sbjct: 529 TGILYALRSFDYEQLRDLQ-----LWVTASDSGDPPLSSNVSLSLFVLDQNDNAPEILYP 583
Query: 307 EVDFYNISIVENLPN----GFSVLQVMATDKDQGENGEFTYQL--DDPKGAFSIDPRSGW 360
+ + VE P G+ V +V+A D+D G+N +Y+L G FS+ +G
Sbjct: 584 ALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGE 643
Query: 361 LTVRNQTVLDREA 373
+ + + +LDR+A
Sbjct: 644 VRMA-RALLDRDA 655
Score = 54.0 bits (124), Expect = 4e-06
Identities = 73/307 (23%), Positives = 127/307 (41%), Gaps = 29/307 (9%)
Query: 83 VTVYIEDVNDNVPIFLDTPYHVTV-DELTPTGEKAFIFLIAP-IGPSLTIPLTVPRGLTI 140
V V I D+NDN P FL V + + P+ + + P +G + +
Sbjct: 137 VEVEIVDINDNTPRFLKEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSHF 196
Query: 141 FKDIRAFDRDKPNTPN----------SDVHYSIVSGNDDGHFALESSHKPVLLLRKVLDY 190
D+++ + P P + Y +V DG + SS +L+ VLD
Sbjct: 197 SVDVQS-EAHGPKYPELVLEGTLDREGEAVYRLVLTAMDGGDPVRSSVAQILVT--VLDV 253
Query: 191 DAGDKEFQLVIMASGKRIHKEILFPE-PIHAIDQDLGVGATLRYELISGNDR--KLFSLD 247
+ F + + + P + A DQD GV + Y + ++ ++F L+
Sbjct: 254 NDNTPMFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFVKITEKISQIFCLN 313
Query: 248 SVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFE 307
+ G + LD + ++ + L V+A + P +A+V I +LD+NDN+PE
Sbjct: 314 VLTGEISTSANLDYE-----DSSFYELGVEAR--DGPGLRDRAKVLITILDVNDNVPEVV 366
Query: 308 VDFYNISIVENLPNGFSVLQVMATDKDQGENGEFTYQLDDPKG-AFSIDPRSG-WLTVRN 365
V + +I E+ P G + D+D G NG T + P+ F ++ G + +
Sbjct: 367 VTSGSRTIAESAPPGTVIALFQVFDRDSGLNGLVTCSI--PRSLPFELEKSVGNYYRLVT 424
Query: 366 QTVLDRE 372
LDRE
Sbjct: 425 NAALDRE 431
Score = 50.0 bits (114), Expect = 6e-05
Identities = 60/220 (27%), Positives = 86/220 (39%), Gaps = 23/220 (10%)
Query: 940 IPENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERHG 999
I E+ P GT I D DSGLNG + + P +L V Y+
Sbjct: 374 IAESAPPGTVIALFQVFDRDSGLNGLVTCSIPRSL---PFELEKS---VGNYY------- 420
Query: 1000 HVIVARSLPPESEFRLNIS--ALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNVE 1055
++ +L E F NI+ A D G L+ + + V D ND+ P F + Y+ V
Sbjct: 421 RLVTNAALDREEVFLYNITVTATDKGTPPLSTETIISLNVADTNDNPPTFPHSSYSVYVL 480
Query: 1056 EAQYTRRVLGKVDATDADFGQNANLTY-----FIQPSDTDLPFEISPLTGVLSVNGELDR 1110
E + V+A D D QNA ++Y +Q + I+ TG+L D
Sbjct: 481 ENNPRGASIFSVNALDPDVDQNAQVSYSLAEDTLQGAPLSSYVSINSDTGILYALRSFDY 540
Query: 1111 ETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
E L V A D+G D NDN+P+
Sbjct: 541 EQLRDLQLWVTASDSG-DPPLSSNVSLSLFVLDQNDNAPE 579
Score = 43.6 bits (98), Expect = 0.006
Identities = 44/169 (26%), Positives = 67/169 (39%), Gaps = 10/169 (5%)
Query: 992 FVINERHGHVIVARSLPPESEFRLNISALDGGNL--NDNIS---VRVFVKDVNDHFPVFK 1046
F +N R+G ++ A + E + L N+ D ++ V V + D+ND+ P F
Sbjct: 93 FSLNPRNGSLVTAGRIDREELCAQSPRCLVSFNILVEDKLNLYPVEVEIVDINDNTPRFL 152
Query: 1047 KTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSD---TDLPFEI-SPLTGVL 1102
K + E ++ D D G N+ + + + D+ E P L
Sbjct: 153 KEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKLSGNSHFSVDVQSEAHGPKYPEL 212
Query: 1103 SVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKF 1151
+ G LDRE E Y L + A D G DVNDN+P F
Sbjct: 213 VLEGTLDREGEAVYRLVLTAMDGG-DPVRSSVAQILVTVLDVNDNTPMF 260
Score = 41.1 bits (92), Expect = 0.030
Identities = 39/132 (29%), Positives = 61/132 (46%), Gaps = 13/132 (9%)
Query: 436 DEQLMSFVNVEVTLLDANDNNP-VFVP------SNLYEFSMKSNAKVGTVIGKVKAVDPD 488
D L S V++ + +LD NDN P + P S E + +S A+ G ++ KV AVD D
Sbjct: 557 DPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRS-AEPGYLVTKVVAVDRD 615
Query: 489 LGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILEG--RHALFVEASDQPANPS 546
GQN + Y L + S + F + +TG V +A + + + +L V D P
Sbjct: 616 SGQNAWLSYRLLKASEPGL---FSVGLHTGEVRMARALLDRDALKQSLVVAVQDHGQPPL 672
Query: 547 ERRYSLAVVTIE 558
+L V +
Sbjct: 673 SATVTLTVAVAD 684
Score = 40.7 bits (91), Expect = 0.039
Identities = 39/126 (30%), Positives = 62/126 (49%), Gaps = 9/126 (7%)
Query: 235 LISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQASQLNNPLKTAQARVEI 294
++S +LFSL+ NGSL +D + L A + V + L K VE+
Sbjct: 84 IVSRGRMQLFSLNPRNGSLVTAGRIDRE---ELCAQSPRCLVSFNILVED-KLNLYPVEV 139
Query: 295 ELLDLNDNLPEFEVDFYNISIVEN-LPNG-FSVLQVMATDKDQGENGEFTYQLDDPKGAF 352
E++D+NDN P F + + I+EN P+ F +++V D D G N ++L F
Sbjct: 140 EIVDINDNTPRFLKEELEVKILENAAPSSRFPLMEVY--DPDVGMNSLQGFKLSG-NSHF 196
Query: 353 SIDPRS 358
S+D +S
Sbjct: 197 SVDVQS 202
Score = 38.7 bits (86), Expect = 0.16
Identities = 74/317 (23%), Positives = 121/317 (38%), Gaps = 47/317 (14%)
Query: 1093 FEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPKFY 1152
F ++P G L G +DRE + N D+NDN+P+F
Sbjct: 93 FSLNPRNGSLVTAGRIDREELCAQSPRCLVSFNILVEDKLNLYPVEVEIVDINDNTPRF- 151
Query: 1153 AFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNGNG 1212
E LE K E S+ ++ VY + N+ G ++ D +G
Sbjct: 152 -LKEELEVKILENAAPSSR----FPLMEVYDPDVGMNSLQGFKLSGNSHFSVDVQSEAHG 206
Query: 1213 -----LILYSLPQRKNQ---------QNLGLPSLSSTAILMVTVADVPDEVEMSDKPVFI 1258
L+L R+ + + G P SS A ++VTV DV D M +PV
Sbjct: 207 PKYPELVLEGTLDREGEAVYRLVLTAMDGGDPVRSSVAQILVTVLDVNDNTPMFTQPV-- 264
Query: 1259 SRYYELEIEENVNAPVELVSLNLTEHYENFKMRY-YILNENDTDIRRTFVIDPRNGTLYL 1317
Y + + EN+ ++++ T+ E Y + I + F ++ G +
Sbjct: 265 ---YRVSVPENLPVGTPVLAVTATDQDEGVHGEVTYSFVKITEKISQIFCLNVLTGEIST 321
Query: 1318 VRSPDREVKDTYEVIVRAERQKYSRELPHMIYPVAEDVLEGMTKYDVKVVVRIKDVNDNS 1377
+ D E YE+ V A R+ P + + KV++ I DVNDN
Sbjct: 322 SANLDYEDSSFYELGVEA------RDGPGL-------------RDRAKVLITILDVNDNV 362
Query: 1378 PK--FTNGNRPLVTAIP 1392
P+ T+G+R + + P
Sbjct: 363 PEVVVTSGSRTIAESAP 379
>BC027907-1|AAH27907.1| 924|Homo sapiens protocadherin 20 protein.
Length = 924
Score = 100 bits (240), Expect = 3e-20
Identities = 115/465 (24%), Positives = 204/465 (43%), Gaps = 36/465 (7%)
Query: 439 LMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYD 498
L+ + + + D NDN P+F S + ++ NA VGT I V+AVD DLG N + Y
Sbjct: 273 LLGSATLTIGISDINDNCPLFTDSQI-NVTVYGNATVGTPIAAVQAVDKDLGTNAQITYS 331
Query: 499 LQRTSNLTITSPFKINPNTGTVSVAES---PILEGRHALFVEASDQPANPSERRYSLAVV 555
+ F ++ NTG + + +LE H L + A+ P+ ++++
Sbjct: 332 YSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLES-HKLTILANGPGCIPAVITALVSII 390
Query: 556 TIEVTRGTKGNKPDI-PDFMGAPYE--FWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLL- 611
+ + R P+I P ++ + ++ + T + + D + V+ L
Sbjct: 391 KV-IFR-----PPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDG 444
Query: 612 HGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDFEAVALQENANLSIVTNATVHVVDVND 671
G P+ ++ + + Y+ VA + V ++D ND
Sbjct: 445 EGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNSEG-FHVKRVIKVQLLDDND 503
Query: 672 ERGVLLKGAHSPII-FHVKEN-SAGAAIGQIFHTNMSSIYGNGTGNVRFLIANQQDVTDD 729
+ L+ P+I ++EN S A + +++ T+ S G V + + D
Sbjct: 504 NAPIFLQ----PLIELTIEENNSPNAFLTKLYATDADS---EERGQVSYFLG--PDAPSY 554
Query: 730 IAI-AEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFE 788
++ + G + LDRE+++ YR TV A + G + V + + D+NDN P F
Sbjct: 555 FSLDSVTGILTVSTQLDREEKEKYRYTVRA-VDCGKPPRESVATVALTVLDKNDNSPRFI 613
Query: 789 HATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKF 848
+ + F+ EN EI +I TDAD G N ++ + ++F +D G+++
Sbjct: 614 NKDFSFFVPENFPGYGEI---GVISVTDADAGRNGWVALSVVNQ-SDIFVIDTGKGMLR- 668
Query: 849 IGDSLDREKKIMYKLSLVARDTG--GLSSEAELIIMIGDENDNKP 891
SLDRE++ Y L + A D G LSS A++ I++ D NDN P
Sbjct: 669 AKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPP 713
Score = 81.4 bits (192), Expect = 2e-14
Identities = 83/324 (25%), Positives = 137/324 (42%), Gaps = 21/324 (6%)
Query: 1031 VRVFVKDVNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTD 1090
++V + D ND+ P+F + +EE L K+ ATDAD + ++YF+ P D
Sbjct: 494 IKVQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGP-DAP 552
Query: 1091 LPFEISPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSPK 1150
F + +TG+L+V+ +LDRE ++KY TV A D G D NDNSP+
Sbjct: 553 SYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCG-KPPRESVATVALTVLDKNDNSPR 611
Query: 1151 FYAFDELLEWKHPEADELSNHNFESVMMIPVYKATIEENAPIGTTVAKVFANDTDFIGNG 1210
F D + PE + + + +I V A N + +V V +D I G
Sbjct: 612 FINKD--FSFFVPE----NFPGYGEIGVISVTDADAGRNGWVALSV--VNQSDIFVIDTG 663
Query: 1211 NGLILYSLPQRKNQQNL----------GLPSLSSTAILMVTVADVPDEVEMSDKPVFISR 1260
G++ + + QQ+ G P+LSSTA + + + D+ D + P
Sbjct: 664 KGMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMS 723
Query: 1261 YYELEIEENVNAPVELVSLNLTEHYENFKMRYYILNENDTDIRRTFVIDPRNGTLYLVRS 1320
Y + +PV V + N + Y I+ +F IDP+ G + L +
Sbjct: 724 YLLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPR-PESFRIDPKTGNITLEEA 782
Query: 1321 PDREVKDTYEVIVRAERQKYSREL 1344
+ + ++V+ Y L
Sbjct: 783 LLQTDYGLHRLLVKVSDHGYPEPL 806
Score = 66.1 bits (154), Expect = 9e-10
Identities = 48/156 (30%), Positives = 74/156 (47%), Gaps = 9/156 (5%)
Query: 740 TQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMEN 799
T KP+D E + Y + V+A ++G I + + D+NDN P+F E I EN
Sbjct: 464 TTKPMDYELQQFYEVAVVAWNSEGFHVKRVI---KVQLLDDNDNAPIFLQPLIELTIEEN 520
Query: 800 SKIGTEIKMDNIIKATDADEGTNALFMYTLFGEGKEMFDVDENTGVVKFIGDSLDREKKI 859
+ + + ATDAD Y L + F +D TG++ + LDRE+K
Sbjct: 521 NSPNAFLTK---LYATDADSEERGQVSYFLGPDAPSYFSLDSVTGILT-VSTQLDREEKE 576
Query: 860 MYKLSLVARDTG--GLSSEAELIIMIGDENDNKPEF 893
Y+ ++ A D G S A + + + D+NDN P F
Sbjct: 577 KYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRF 612
Score = 65.7 bits (153), Expect = 1e-09
Identities = 62/207 (29%), Positives = 97/207 (46%), Gaps = 14/207 (6%)
Query: 744 LDREKRDVYRMTVIAEFNKGVISGAGIYQVTIYIEDENDNPPVFEHATYEGFIMENSKIG 803
LDRE +D Y +IAE + G G +TI I D NDN P+F + + N+ +G
Sbjct: 251 LDRETQDQYVSIIIAE-DGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVG 309
Query: 804 TEIKMDNIIKATDADEGTNALFMYTLFGE----GKEMFDVDENTGVVKFIGDSLDREKKI 859
T I ++A D D GTNA Y+ + K++F +DENTGV+K +
Sbjct: 310 TPIA---AVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLF-SKIGGSVLE 365
Query: 860 MYKLSLVARDTG----GLSSEAELIIMIGDENDNKPEFNQIEENSKVRIHRETKLN-GTA 914
+KL+++A G +++ +I +I + P + E + V + +N A
Sbjct: 366 SHKLTILANGPGCIPAVITALVSIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIA 425
Query: 915 GFTIIEVKPKNKFALDVDQLGPLFLIP 941
FTI + + K K +D GP L P
Sbjct: 426 FFTIRDPEGKYKVNCYLDGEGPFRLSP 452
Score = 64.1 bits (149), Expect = 4e-09
Identities = 53/171 (30%), Positives = 75/171 (43%), Gaps = 10/171 (5%)
Query: 214 FPEPIHAIDQDLGVGATLRYELISGNDR-KLFSLDSVNGSLFLEKELDLDAEHNLQANTF 272
F ++A D D + Y L G D FSLDSV G L + +LD + + +
Sbjct: 526 FLTKLYATDADSEERGQVSYFL--GPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYT-- 581
Query: 273 VLQVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATD 332
V+A P + + A V + +LD NDN P F ++ + EN P + + TD
Sbjct: 582 ---VRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTD 638
Query: 333 KDQGENGEFTYQLDDPKGAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
D G NG + + F ID G L R + LDRE SS + V A
Sbjct: 639 ADAGRNGWVALSVVNQSDIFVIDTGKGML--RAKVSLDREQQSSYTLWVEA 687
Score = 62.1 bits (144), Expect = 1e-08
Identities = 69/254 (27%), Positives = 114/254 (44%), Gaps = 22/254 (8%)
Query: 599 DAFEQNDVSYDLLHGYEEGVPFAVEERSGVITVVDDLSRYNRPMYDF--EAVALQENANL 656
D+ E+ VSY L G + F+++ +G++TV L R + Y + AV +
Sbjct: 536 DSEERGQVSYFL--GPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRE 593
Query: 657 SIVTNATVHVVDVNDERGVLLKGAHSPIIFHVKENSAGAAIGQIFHTNMSSIYGNGTGNV 716
S+ T A V+D ND + S F V EN G G+I +++ G V
Sbjct: 594 SVATVALT-VLDKNDNSPRFINKDFS---FFVPENFPG--YGEIGVISVTDADAGRNGWV 647
Query: 717 RFLIANQQDVTDDIAIAEDGTIFTQKPLDREKRDVYRMTVIAEFNKGVISGAGIYQVTIY 776
+ NQ D+ + G + + LDRE++ Y + V A + G + + ++TI
Sbjct: 648 ALSVVNQSDIF--VIDTGKGMLRAKVSLDREQQSSYTLWVEA-VDGGEPALSSTAKITIL 704
Query: 777 IEDENDNPP--VFEHATYEGFIMENSKI-GTEIKMDNIIKATDADEGTNALFMYTLFGE- 832
+ D NDNPP +F + ++ S + G+ + + A D D G NA+ Y++ G
Sbjct: 705 LLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPV---TEVYAVDKDTGMNAVIAYSIIGRR 761
Query: 833 --GKEMFDVDENTG 844
E F +D TG
Sbjct: 762 GPRPESFRIDPKTG 775
Score = 61.3 bits (142), Expect = 3e-08
Identities = 47/153 (30%), Positives = 77/153 (50%), Gaps = 14/153 (9%)
Query: 218 IHAIDQDLGVGATLRYELISGNDRKLFSLDSVNGSLFLEKELDLDAEHNLQANTFVLQVQ 277
I D D G + +++ +D +F +D+ G L ++ LD E Q +++ L V+
Sbjct: 634 ISVTDADAGRNGWVALSVVNQSD--IFVIDTGKG--MLRAKVSLDRE---QQSSYTLWVE 686
Query: 278 ASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPN---GFSVLQVMATDKD 334
A P ++ A++ I LLD+NDN P N+S + LP+ G V +V A DKD
Sbjct: 687 AVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKD 746
Query: 335 QGENGEFTYQLDDPKG----AFSIDPRSGWLTV 363
G N Y + +G +F IDP++G +T+
Sbjct: 747 TGMNAVIAYSIIGRRGPRPESFRIDPKTGNITL 779
Score = 58.8 bits (136), Expect = 1e-07
Identities = 45/138 (32%), Positives = 64/138 (46%), Gaps = 9/138 (6%)
Query: 772 QVTIYIEDENDNPPVFEHATYEGFIMENSKIGTEIKMDNIIKATDADEGTNALFMYTLFG 831
+V I I D NDN P F + ++ EN+ + T + +++ A D D G N + Y L
Sbjct: 167 KVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEH--PAVDPDVGINGVQTYRLLD 224
Query: 832 -EGKEMFDVDENTGVVK----FIGDSLDREKKIMYKLSLVARDTGG--LSSEAELIIMIG 884
G DV+EN + + +LDRE + Y ++A D G L A L I I
Sbjct: 225 YHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGIS 284
Query: 885 DENDNKPEFNQIEENSKV 902
D NDN P F + N V
Sbjct: 285 DINDNCPLFTDSQINVTV 302
Score = 58.8 bits (136), Expect = 1e-07
Identities = 65/232 (28%), Positives = 96/232 (41%), Gaps = 28/232 (12%)
Query: 929 LDVDQLGPLFLIP-------ENIPIGTTIIKLNALDLDSGLNGQIRYEFNSEVYIPPSKL 981
LD + P+FL P EN + KL A D DS GQ+ Y ++ P
Sbjct: 499 LDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSY------FLGP--- 549
Query: 982 SADALEVKRYFVINERHGHVIVARSLPPE--SEFRLNISALDGGN--LNDNISVRVFVKD 1037
+ YF ++ G + V+ L E ++R + A+D G +V + V D
Sbjct: 550 -----DAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLD 604
Query: 1038 VNDHFPVFKKTWYNFNVEEAQYTRRVLGKVDATDADFGQNANLTYFIQPSDTDLPFEISP 1097
ND+ P F ++F V E +G + TDAD G+N + + + +D+ F I
Sbjct: 605 KNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSV-VNQSDI-FVIDT 662
Query: 1098 LTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXXDVNDNSP 1149
G+L LDRE + Y L V A D G D+NDN P
Sbjct: 663 GKGMLRAKVSLDREQQSSYTLWVEAVDGG-EPALSSTAKITILLLDINDNPP 713
Score = 57.6 bits (133), Expect = 3e-07
Identities = 53/196 (27%), Positives = 90/196 (45%), Gaps = 18/196 (9%)
Query: 940 IPENIPIGTTI-IKLNALDLDSGLNGQIRYEFNSEVYIPPSKLSADALEVKRYFVINERH 998
+PEN P+ T + I+ A+D D G+NG Y + D E + ER
Sbjct: 191 VPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLDY----HGMFTLDVEENEN----GERT 242
Query: 999 GHVIVARSLPPESE--FRLNISALDGGN--LNDNISVRVFVKDVNDHFPVFKKTWYNFNV 1054
++IV +L E++ + I A DGG+ L + ++ + + D+ND+ P+F + N V
Sbjct: 243 PYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTV 302
Query: 1055 EEAQYTRRVLGKVDATDADFGQNANLTYF----IQPSDTDLPFEISPLTGVLSVNGELDR 1110
+ V A D D G NA +TY + + DL F + TGV+ + ++
Sbjct: 303 YGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDL-FHLDENTGVIKLFSKIGG 361
Query: 1111 ETEDKYILTVVARDNG 1126
+ + LT++A G
Sbjct: 362 SVLESHKLTILANGPG 377
Score = 55.6 bits (128), Expect = 1e-06
Identities = 64/237 (27%), Positives = 103/237 (43%), Gaps = 18/237 (7%)
Query: 445 VEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIGKVKAVDPDLGQNGMVLYDLQRTSN 504
++V LLD NDN P+F+ L E +++ N + K+ A D D + G V Y L +
Sbjct: 494 IKVQLLDDNDNAPIFL-QPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDA- 551
Query: 505 LTITSPFKINPNTG--TVSVAESPILEGRHALFVEASDQPANPSERRYSLAVVTIEVTRG 562
S F ++ TG TVS + ++ V A D P E +V T+ +T
Sbjct: 552 ---PSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRE-----SVATVALTVL 603
Query: 563 TKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLHGYEEGVPFAV 622
K + + P F+ + F+V N +G I V DA + + L + F +
Sbjct: 604 DKND--NSPRFINKDFSFFVPENFPGYGEIGVISVTDA-DAGRNGWVALSVVNQSDIFVI 660
Query: 623 EERSGVITVVDDLSRYNRPMYDF--EAVALQENANLSIVTNATVHVVDVNDERGVLL 677
+ G++ L R + Y EAV E A LS T+ ++D+ND ++L
Sbjct: 661 DTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPA-LSSTAKITILLLDINDNPPLVL 716
Score = 55.6 bits (128), Expect = 1e-06
Identities = 38/94 (40%), Positives = 51/94 (54%), Gaps = 5/94 (5%)
Query: 292 VEIELLDLNDNLPEFEVDFYNISIVE-NLPNGFSVLQVMATDKDQGENGEFTYQL-DDPK 349
++++LLD NDN P F ++I E N PN F + ++ ATD D E G+ +Y L D
Sbjct: 494 IKVQLLDDNDNAPIFLQPLIELTIEENNSPNAF-LTKLYATDADSEERGQVSYFLGPDAP 552
Query: 350 GAFSIDPRSGWLTVRNQTVLDREAHSSLRMKVYA 383
FS+D +G LTV Q LDRE R V A
Sbjct: 553 SYFSLDSVTGILTVSTQ--LDREEKEKYRYTVRA 584
Score = 53.6 bits (123), Expect = 5e-06
Identities = 37/129 (28%), Positives = 57/129 (44%), Gaps = 7/129 (5%)
Query: 1029 ISVRVFVKDVNDHFPVFKKTWYNFNV-EEAQYTRRVLGKVDATDADFGQNANLTYFIQPS 1087
+ V++ ++D+ND+ P F + + V E A R+ + A D D G N TY +
Sbjct: 166 VKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLDY 225
Query: 1088 DTDLPFEI-----SPLTGVLSVNGELDRETEDKYILTVVARDNGXXXXXXXXXXXXXXXX 1142
++ T L V G LDRET+D+Y+ ++A D G
Sbjct: 226 HGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGG-SPPLLGSATLTIGIS 284
Query: 1143 DVNDNSPKF 1151
D+NDN P F
Sbjct: 285 DINDNCPLF 293
Score = 53.2 bits (122), Expect = 7e-06
Identities = 35/115 (30%), Positives = 58/115 (50%), Gaps = 5/115 (4%)
Query: 430 ENIEYYDEQLMSFVNVEVTLLDANDNNPV--FVPSNLYEFSMKSNAKVGTVIGKVKAVDP 487
E ++ + L S + + LLD NDN P+ F SN+ + + G+ + +V AVD
Sbjct: 686 EAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDK 745
Query: 488 DLGQNGMVLYDLQRTSNLTITSPFKINPNTGTVSVAESPILE--GRHALFVEASD 540
D G N ++ Y + S F+I+P TG +++ E+ + G H L V+ SD
Sbjct: 746 DTGMNAVIAYSIIGRRGPRPES-FRIDPKTGNITLEEALLQTDYGLHRLLVKVSD 799
Score = 52.8 bits (121), Expect = 9e-06
Identities = 49/168 (29%), Positives = 82/168 (48%), Gaps = 15/168 (8%)
Query: 291 RVEIELLDLNDNLPEFEVDFYNISIVENLP-NGFSVLQVMATDKDQGENGEFTYQLDDPK 349
+V+I + D+NDN P+F V ++ + EN P N ++ A D D G NG TY+L D
Sbjct: 167 KVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLDYH 226
Query: 350 GAFSID-------PRSGWLTVRNQTVLDREAHSSLRMKVYAKE-TNPSVVGTFADSQRIA 401
G F++D R+ +L V LDRE + A++ +P ++G+ + I+
Sbjct: 227 GMFTLDVEENENGERTPYLIVMG--ALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGIS 284
Query: 402 KWRRQ-PLETNAPLEKTTYVFPDKVGTKTENIEYYDEQLMSFVNVEVT 448
PL T++ + T Y VGT ++ D+ L + N ++T
Sbjct: 285 DINDNCPLFTDSQINVTVY-GNATVGTPIAAVQAVDKDLGT--NAQIT 329
Score = 50.0 bits (114), Expect = 6e-05
Identities = 43/150 (28%), Positives = 65/150 (43%), Gaps = 15/150 (10%)
Query: 220 AIDQDLGVGATLRYELISGNDRKLFSLD---SVNGSL--FLEKELDLDAEHNLQANTFVL 274
A+D D+G+ Y L+ + +F+LD + NG +L LD E Q +V
Sbjct: 207 AVDPDVGINGVQTYRLLDYHG--MFTLDVEENENGERTPYLIVMGALDRETQDQ---YVS 261
Query: 275 QVQASQLNNPLKTAQARVEIELLDLNDNLPEFEVDFYNISIVENLPNGFSVLQVMATDKD 334
+ A +P A + I + D+NDN P F N+++ N G + V A DKD
Sbjct: 262 IIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKD 321
Query: 335 QGENGEFTYQLDD-----PKGAFSIDPRSG 359
G N + TY K F +D +G
Sbjct: 322 LGTNAQITYSYSQKVPQASKDLFHLDENTG 351
Score = 44.0 bits (99), Expect = 0.004
Identities = 53/203 (26%), Positives = 87/203 (42%), Gaps = 19/203 (9%)
Query: 437 EQLMSFVNVEVTLLDANDNNPVFVPSNLYEFSMKSNAKVGTVIG-KVKAVDPDLGQNGMV 495
++ FV V++ + D NDN P F P + + NA V T + + AVDPD+G NG+
Sbjct: 160 QEYFRFVKVKIAIRDINDNAPQF-PVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQ 218
Query: 496 LYDLQRTSNLTITSPFKINPNTGTVSVAESPILEGRHALFVEASDQPAN--PSERRYSLA 553
Y L + T + N N +P L AL E DQ + +E S
Sbjct: 219 TYRLLDYHGM-FTLDVEENENG-----ERTPYLIVMGALDRETQDQYVSIIIAEDGGSPP 272
Query: 554 VV-TIEVTRGTKGNKPDIPDFMGAPYEFWVGSNVGIGTSVGQIRVNDAFEQNDVSYDLLH 612
++ + +T G + P F + V N +GT + ++ D + + + +
Sbjct: 273 LLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVD--KDLGTNAQITY 330
Query: 613 GYEEGVP------FAVEERSGVI 629
Y + VP F ++E +GVI
Sbjct: 331 SYSQKVPQASKDLFHLDENTGVI 353
Score = 37.1 bits (82), Expect = 0.48
Identities = 22/58 (37%), Positives = 30/58 (51%), Gaps = 3/58 (5%)
Query: 1425 LVFFERLSLNGLTSPQATDSDIGINADIRYQILNEQAPR---FAIDPVSGTVRVVAAL 1479
LV L + +T A D D G+NA I Y I+ + PR F IDP +G + + AL
Sbjct: 726 LVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEAL 783
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.317 0.136 0.387
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 209,727,393
Number of Sequences: 224733
Number of extensions: 9268216
Number of successful extensions: 49258
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 532
Number of HSP's successfully gapped in prelim test: 43
Number of HSP's that attempted gapping in prelim test: 18507
Number of HSP's gapped (non-prelim): 17403
length of query: 1518
length of database: 73,234,838
effective HSP length: 100
effective length of query: 1418
effective length of database: 50,761,538
effective search space: 71979860884
effective search space used: 71979860884
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.6 bits)
S2: 72 (33.1 bits)
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