Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002719-TA|BGIBMGA002719-PA|IPR008266|Tyrosine protein
kinase, active site, IPR000649|Initiation factor 2B related
(716 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
BC091502-1|AAH91502.1| 523|Homo sapiens eukaryotic translation ... 266 2e-70
BC001870-1|AAH01870.1| 523|Homo sapiens eukaryotic translation ... 266 2e-70
AL050109-1|CAB43277.1| 394|Homo sapiens hypothetical protein pr... 266 2e-70
AJ011307-2|CAB57305.1| 542|Homo sapiens guanine nucleotide exch... 266 2e-70
AJ011307-1|CAB57304.1| 522|Homo sapiens guanine nucleotide exch... 266 2e-70
AJ011306-1|CAB57261.1| 543|Homo sapiens guanine nucleotide exch... 266 2e-70
AJ011305-1|CAB57260.1| 522|Homo sapiens guanine nucleotide exch... 266 2e-70
AF057699-1|AAQ13438.1| 520|Homo sapiens EIF-2B-delta-like prote... 266 2e-70
AC074117-8|AAY14843.1| 522|Homo sapiens unknown protein. 266 2e-70
AF112207-1|AAF17195.1| 523|Homo sapiens translation initiation ... 264 1e-69
X95648-1|CAA64950.1| 305|Homo sapiens eIF-2B protein. 60 2e-08
CR456831-1|CAG33112.1| 305|Homo sapiens EIF2B1 protein. 60 2e-08
BC104189-1|AAI04190.1| 305|Homo sapiens eukaryotic translation ... 60 2e-08
BC104188-1|AAI04189.1| 305|Homo sapiens eukaryotic translation ... 60 2e-08
BC103763-1|AAI03764.1| 305|Homo sapiens eukaryotic translation ... 60 2e-08
AF218009-1|AAG17251.1| 229|Homo sapiens unknown protein. 60 2e-08
L02320-1|AAA36541.1| 583|Homo sapiens radixin protein. 32 8.1
BC047109-1|AAH47109.1| 583|Homo sapiens radixin protein. 32 8.1
>BC091502-1|AAH91502.1| 523|Homo sapiens eukaryotic translation
initiation factor 2B, subunit 4 delta, 67kDa protein.
Length = 523
Score = 266 bits (652), Expect = 2e-70
Identities = 144/344 (41%), Positives = 199/344 (57%), Gaps = 4/344 (1%)
Query: 373 FQHLYTEFDKNPLKK---IPINSNLHPAIVKLGVQLSSRVVKGSNARCIALLDALNKMVR 429
F HL +N L + IP +S +HPA+V+LG+Q S +V GSNARCIALL AL ++++
Sbjct: 180 FSHLPQYSRQNSLTQFMSIP-SSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQ 238
Query: 430 DYVLPAKTEFSRGLESHLASSLEFLWTTREPCASQINAVKFFRHHLAQLPNNVDEFDAKK 489
DY P E SR L + L + FL R AS NA+KF + + ++ E +AK
Sbjct: 239 DYTTPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKS 298
Query: 490 TLQEEIDRYIREQIEMAGEAISIAVRNKISNGDTILTYGCSSLIEQILCEAWEAGLQFRT 549
L+ IDRY++E+I +A +AIS KISNGD IL YGCSSL+ +IL EAW G +FR
Sbjct: 299 ELRAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRV 358
Query: 550 LVVGSRVSPDAAEMLRRLCARGLPCTYVDFTAVNYVMKTVSKXXXXXXXXXXXXXXXXXX 609
+VV SR + LR L G+P +Y+ A +YV+ VSK
Sbjct: 359 VVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRV 418
Query: 610 XXXXXXXXXXXXXXPVLVACHTHKFIDSLYTDAFMHNQIGDPDDLLEKSDDNSPLKDWRS 669
PVLV C T+KF + + TDAF+ N++ DPDDL K ++ L +W++
Sbjct: 419 GTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQN 478
Query: 670 NLNLTPLNLTYDVTPPCLITAVVTELAILPCTSAPVVLRFKLSE 713
+ +L LNL YDVTPP L+ V+TEL ++PC+S PVVLR K S+
Sbjct: 479 HASLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSD 522
>BC001870-1|AAH01870.1| 523|Homo sapiens eukaryotic translation
initiation factor 2B, subunit 4 delta, 67kDa protein.
Length = 523
Score = 266 bits (652), Expect = 2e-70
Identities = 144/344 (41%), Positives = 199/344 (57%), Gaps = 4/344 (1%)
Query: 373 FQHLYTEFDKNPLKK---IPINSNLHPAIVKLGVQLSSRVVKGSNARCIALLDALNKMVR 429
F HL +N L + IP +S +HPA+V+LG+Q S +V GSNARCIALL AL ++++
Sbjct: 180 FSHLPQYSRQNSLTQFMSIP-SSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQ 238
Query: 430 DYVLPAKTEFSRGLESHLASSLEFLWTTREPCASQINAVKFFRHHLAQLPNNVDEFDAKK 489
DY P E SR L + L + FL R AS NA+KF + + ++ E +AK
Sbjct: 239 DYTTPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKS 298
Query: 490 TLQEEIDRYIREQIEMAGEAISIAVRNKISNGDTILTYGCSSLIEQILCEAWEAGLQFRT 549
L+ IDRY++E+I +A +AIS KISNGD IL YGCSSL+ +IL EAW G +FR
Sbjct: 299 ELRAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRV 358
Query: 550 LVVGSRVSPDAAEMLRRLCARGLPCTYVDFTAVNYVMKTVSKXXXXXXXXXXXXXXXXXX 609
+VV SR + LR L G+P +Y+ A +YV+ VSK
Sbjct: 359 VVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRV 418
Query: 610 XXXXXXXXXXXXXXPVLVACHTHKFIDSLYTDAFMHNQIGDPDDLLEKSDDNSPLKDWRS 669
PVLV C T+KF + + TDAF+ N++ DPDDL K ++ L +W++
Sbjct: 419 GTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQN 478
Query: 670 NLNLTPLNLTYDVTPPCLITAVVTELAILPCTSAPVVLRFKLSE 713
+ +L LNL YDVTPP L+ V+TEL ++PC+S PVVLR K S+
Sbjct: 479 HASLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSD 522
>AL050109-1|CAB43277.1| 394|Homo sapiens hypothetical protein
protein.
Length = 394
Score = 266 bits (652), Expect = 2e-70
Identities = 144/344 (41%), Positives = 199/344 (57%), Gaps = 4/344 (1%)
Query: 373 FQHLYTEFDKNPLKK---IPINSNLHPAIVKLGVQLSSRVVKGSNARCIALLDALNKMVR 429
F HL +N L + IP +S +HPA+V+LG+Q S +V GSNARCIALL AL ++++
Sbjct: 51 FSHLPQYSRQNSLTQFMSIP-SSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQ 109
Query: 430 DYVLPAKTEFSRGLESHLASSLEFLWTTREPCASQINAVKFFRHHLAQLPNNVDEFDAKK 489
DY P E SR L + L + FL R AS NA+KF + + ++ E +AK
Sbjct: 110 DYTTPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKS 169
Query: 490 TLQEEIDRYIREQIEMAGEAISIAVRNKISNGDTILTYGCSSLIEQILCEAWEAGLQFRT 549
L+ IDRY++E+I +A +AIS KISNGD IL YGCSSL+ +IL EAW G +FR
Sbjct: 170 ELRAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRV 229
Query: 550 LVVGSRVSPDAAEMLRRLCARGLPCTYVDFTAVNYVMKTVSKXXXXXXXXXXXXXXXXXX 609
+VV SR + LR L G+P +Y+ A +YV+ VSK
Sbjct: 230 VVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRV 289
Query: 610 XXXXXXXXXXXXXXPVLVACHTHKFIDSLYTDAFMHNQIGDPDDLLEKSDDNSPLKDWRS 669
PVLV C T+KF + + TDAF+ N++ DPDDL K ++ L +W++
Sbjct: 290 GTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQN 349
Query: 670 NLNLTPLNLTYDVTPPCLITAVVTELAILPCTSAPVVLRFKLSE 713
+ +L LNL YDVTPP L+ V+TEL ++PC+S PVVLR K S+
Sbjct: 350 HASLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSD 393
>AJ011307-2|CAB57305.1| 542|Homo sapiens guanine nucleotide
exchange factor protein.
Length = 542
Score = 266 bits (652), Expect = 2e-70
Identities = 144/344 (41%), Positives = 199/344 (57%), Gaps = 4/344 (1%)
Query: 373 FQHLYTEFDKNPLKK---IPINSNLHPAIVKLGVQLSSRVVKGSNARCIALLDALNKMVR 429
F HL +N L + IP +S +HPA+V+LG+Q S +V GSNARCIALL AL ++++
Sbjct: 199 FSHLPQYSRQNSLTQFMTIP-SSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQ 257
Query: 430 DYVLPAKTEFSRGLESHLASSLEFLWTTREPCASQINAVKFFRHHLAQLPNNVDEFDAKK 489
DY P E SR L + L + FL R AS NA+KF + + ++ E +AK
Sbjct: 258 DYTTPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKS 317
Query: 490 TLQEEIDRYIREQIEMAGEAISIAVRNKISNGDTILTYGCSSLIEQILCEAWEAGLQFRT 549
L+ IDRY++E+I +A +AIS KISNGD IL YGCSSL+ +IL EAW G +FR
Sbjct: 318 ELRAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRV 377
Query: 550 LVVGSRVSPDAAEMLRRLCARGLPCTYVDFTAVNYVMKTVSKXXXXXXXXXXXXXXXXXX 609
+VV SR + LR L G+P +Y+ A +YV+ VSK
Sbjct: 378 VVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRV 437
Query: 610 XXXXXXXXXXXXXXPVLVACHTHKFIDSLYTDAFMHNQIGDPDDLLEKSDDNSPLKDWRS 669
PVLV C T+KF + + TDAF+ N++ DPDDL K ++ L +W++
Sbjct: 438 GTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQN 497
Query: 670 NLNLTPLNLTYDVTPPCLITAVVTELAILPCTSAPVVLRFKLSE 713
+ +L LNL YDVTPP L+ V+TEL ++PC+S PVVLR K S+
Sbjct: 498 HASLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSD 541
>AJ011307-1|CAB57304.1| 522|Homo sapiens guanine nucleotide
exchange factor protein.
Length = 522
Score = 266 bits (652), Expect = 2e-70
Identities = 144/344 (41%), Positives = 199/344 (57%), Gaps = 4/344 (1%)
Query: 373 FQHLYTEFDKNPLKK---IPINSNLHPAIVKLGVQLSSRVVKGSNARCIALLDALNKMVR 429
F HL +N L + IP +S +HPA+V+LG+Q S +V GSNARCIALL AL ++++
Sbjct: 179 FSHLPQYSRQNSLTQFMTIP-SSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQ 237
Query: 430 DYVLPAKTEFSRGLESHLASSLEFLWTTREPCASQINAVKFFRHHLAQLPNNVDEFDAKK 489
DY P E SR L + L + FL R AS NA+KF + + ++ E +AK
Sbjct: 238 DYTTPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKS 297
Query: 490 TLQEEIDRYIREQIEMAGEAISIAVRNKISNGDTILTYGCSSLIEQILCEAWEAGLQFRT 549
L+ IDRY++E+I +A +AIS KISNGD IL YGCSSL+ +IL EAW G +FR
Sbjct: 298 ELRAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRV 357
Query: 550 LVVGSRVSPDAAEMLRRLCARGLPCTYVDFTAVNYVMKTVSKXXXXXXXXXXXXXXXXXX 609
+VV SR + LR L G+P +Y+ A +YV+ VSK
Sbjct: 358 VVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRV 417
Query: 610 XXXXXXXXXXXXXXPVLVACHTHKFIDSLYTDAFMHNQIGDPDDLLEKSDDNSPLKDWRS 669
PVLV C T+KF + + TDAF+ N++ DPDDL K ++ L +W++
Sbjct: 418 GTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQN 477
Query: 670 NLNLTPLNLTYDVTPPCLITAVVTELAILPCTSAPVVLRFKLSE 713
+ +L LNL YDVTPP L+ V+TEL ++PC+S PVVLR K S+
Sbjct: 478 HASLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSD 521
>AJ011306-1|CAB57261.1| 543|Homo sapiens guanine nucleotide
exchange factor (long isoform) protein.
Length = 543
Score = 266 bits (652), Expect = 2e-70
Identities = 144/344 (41%), Positives = 199/344 (57%), Gaps = 4/344 (1%)
Query: 373 FQHLYTEFDKNPLKK---IPINSNLHPAIVKLGVQLSSRVVKGSNARCIALLDALNKMVR 429
F HL +N L + IP +S +HPA+V+LG+Q S +V GSNARCIALL AL ++++
Sbjct: 200 FSHLPQYSRQNSLTQFMTIP-SSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQ 258
Query: 430 DYVLPAKTEFSRGLESHLASSLEFLWTTREPCASQINAVKFFRHHLAQLPNNVDEFDAKK 489
DY P E SR L + L + FL R AS NA+KF + + ++ E +AK
Sbjct: 259 DYTTPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKS 318
Query: 490 TLQEEIDRYIREQIEMAGEAISIAVRNKISNGDTILTYGCSSLIEQILCEAWEAGLQFRT 549
L+ IDRY++E+I +A +AIS KISNGD IL YGCSSL+ +IL EAW G +FR
Sbjct: 319 ELRAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRV 378
Query: 550 LVVGSRVSPDAAEMLRRLCARGLPCTYVDFTAVNYVMKTVSKXXXXXXXXXXXXXXXXXX 609
+VV SR + LR L G+P +Y+ A +YV+ VSK
Sbjct: 379 VVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRV 438
Query: 610 XXXXXXXXXXXXXXPVLVACHTHKFIDSLYTDAFMHNQIGDPDDLLEKSDDNSPLKDWRS 669
PVLV C T+KF + + TDAF+ N++ DPDDL K ++ L +W++
Sbjct: 439 GTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQN 498
Query: 670 NLNLTPLNLTYDVTPPCLITAVVTELAILPCTSAPVVLRFKLSE 713
+ +L LNL YDVTPP L+ V+TEL ++PC+S PVVLR K S+
Sbjct: 499 HASLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSD 542
>AJ011305-1|CAB57260.1| 522|Homo sapiens guanine nucleotide
exchange factor, delta subunit protein.
Length = 522
Score = 266 bits (652), Expect = 2e-70
Identities = 144/344 (41%), Positives = 199/344 (57%), Gaps = 4/344 (1%)
Query: 373 FQHLYTEFDKNPLKK---IPINSNLHPAIVKLGVQLSSRVVKGSNARCIALLDALNKMVR 429
F HL +N L + IP +S +HPA+V+LG+Q S +V GSNARCIALL AL ++++
Sbjct: 179 FSHLPQYSRQNSLTQFMTIP-SSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQ 237
Query: 430 DYVLPAKTEFSRGLESHLASSLEFLWTTREPCASQINAVKFFRHHLAQLPNNVDEFDAKK 489
DY P E SR L + L + FL R AS NA+KF + + ++ E +AK
Sbjct: 238 DYTTPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKS 297
Query: 490 TLQEEIDRYIREQIEMAGEAISIAVRNKISNGDTILTYGCSSLIEQILCEAWEAGLQFRT 549
L+ IDRY++E+I +A +AIS KISNGD IL YGCSSL+ +IL EAW G +FR
Sbjct: 298 ELRAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRV 357
Query: 550 LVVGSRVSPDAAEMLRRLCARGLPCTYVDFTAVNYVMKTVSKXXXXXXXXXXXXXXXXXX 609
+VV SR + LR L G+P +Y+ A +YV+ VSK
Sbjct: 358 VVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRV 417
Query: 610 XXXXXXXXXXXXXXPVLVACHTHKFIDSLYTDAFMHNQIGDPDDLLEKSDDNSPLKDWRS 669
PVLV C T+KF + + TDAF+ N++ DPDDL K ++ L +W++
Sbjct: 418 GTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQN 477
Query: 670 NLNLTPLNLTYDVTPPCLITAVVTELAILPCTSAPVVLRFKLSE 713
+ +L LNL YDVTPP L+ V+TEL ++PC+S PVVLR K S+
Sbjct: 478 HASLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSD 521
>AF057699-1|AAQ13438.1| 520|Homo sapiens EIF-2B-delta-like protein
protein.
Length = 520
Score = 266 bits (652), Expect = 2e-70
Identities = 144/344 (41%), Positives = 199/344 (57%), Gaps = 4/344 (1%)
Query: 373 FQHLYTEFDKNPLKK---IPINSNLHPAIVKLGVQLSSRVVKGSNARCIALLDALNKMVR 429
F HL +N L + IP +S +HPA+V+LG+Q S +V GSNARCIALL AL ++++
Sbjct: 177 FSHLPQYSRQNSLTQFMSIP-SSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQ 235
Query: 430 DYVLPAKTEFSRGLESHLASSLEFLWTTREPCASQINAVKFFRHHLAQLPNNVDEFDAKK 489
DY P E SR L + L + FL R AS NA+KF + + ++ E +AK
Sbjct: 236 DYTTPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKS 295
Query: 490 TLQEEIDRYIREQIEMAGEAISIAVRNKISNGDTILTYGCSSLIEQILCEAWEAGLQFRT 549
L+ IDRY++E+I +A +AIS KISNGD IL YGCSSL+ +IL EAW G +FR
Sbjct: 296 ELRAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRV 355
Query: 550 LVVGSRVSPDAAEMLRRLCARGLPCTYVDFTAVNYVMKTVSKXXXXXXXXXXXXXXXXXX 609
+VV SR + LR L G+P +Y+ A +YV+ VSK
Sbjct: 356 VVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRV 415
Query: 610 XXXXXXXXXXXXXXPVLVACHTHKFIDSLYTDAFMHNQIGDPDDLLEKSDDNSPLKDWRS 669
PVLV C T+KF + + TDAF+ N++ DPDDL K ++ L +W++
Sbjct: 416 GTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQN 475
Query: 670 NLNLTPLNLTYDVTPPCLITAVVTELAILPCTSAPVVLRFKLSE 713
+ +L LNL YDVTPP L+ V+TEL ++PC+S PVVLR K S+
Sbjct: 476 HASLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSD 519
>AC074117-8|AAY14843.1| 522|Homo sapiens unknown protein.
Length = 522
Score = 266 bits (652), Expect = 2e-70
Identities = 144/344 (41%), Positives = 199/344 (57%), Gaps = 4/344 (1%)
Query: 373 FQHLYTEFDKNPLKK---IPINSNLHPAIVKLGVQLSSRVVKGSNARCIALLDALNKMVR 429
F HL +N L + IP +S +HPA+V+LG+Q S +V GSNARCIALL AL ++++
Sbjct: 179 FSHLPQYSRQNSLTQFMSIP-SSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQ 237
Query: 430 DYVLPAKTEFSRGLESHLASSLEFLWTTREPCASQINAVKFFRHHLAQLPNNVDEFDAKK 489
DY P E SR L + L + FL R AS NA+KF + + ++ E +AK
Sbjct: 238 DYTTPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKS 297
Query: 490 TLQEEIDRYIREQIEMAGEAISIAVRNKISNGDTILTYGCSSLIEQILCEAWEAGLQFRT 549
L+ IDRY++E+I +A +AIS KISNGD IL YGCSSL+ +IL EAW G +FR
Sbjct: 298 ELRAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRV 357
Query: 550 LVVGSRVSPDAAEMLRRLCARGLPCTYVDFTAVNYVMKTVSKXXXXXXXXXXXXXXXXXX 609
+VV SR + LR L G+P +Y+ A +YV+ VSK
Sbjct: 358 VVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRV 417
Query: 610 XXXXXXXXXXXXXXPVLVACHTHKFIDSLYTDAFMHNQIGDPDDLLEKSDDNSPLKDWRS 669
PVLV C T+KF + + TDAF+ N++ DPDDL K ++ L +W++
Sbjct: 418 GTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQN 477
Query: 670 NLNLTPLNLTYDVTPPCLITAVVTELAILPCTSAPVVLRFKLSE 713
+ +L LNL YDVTPP L+ V+TEL ++PC+S PVVLR K S+
Sbjct: 478 HASLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSD 521
>AF112207-1|AAF17195.1| 523|Homo sapiens translation initiation
factor eIF-2b delta subunit protein.
Length = 523
Score = 264 bits (646), Expect = 1e-69
Identities = 144/344 (41%), Positives = 198/344 (57%), Gaps = 4/344 (1%)
Query: 373 FQHLYTEFDKNPLKK---IPINSNLHPAIVKLGVQLSSRVVKGSNARCIALLDALNKMVR 429
F HL +N L + IP +S +HPA+V+LG+Q S +V GSNARCIALL AL ++++
Sbjct: 180 FSHLPQYSRQNSLTQFMSIP-SSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQ 238
Query: 430 DYVLPAKTEFSRGLESHLASSLEFLWTTREPCASQINAVKFFRHHLAQLPNNVDEFDAKK 489
DY P E SR L + L + FL R AS NA+KF + + ++ E +AK
Sbjct: 239 DYTTPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKS 298
Query: 490 TLQEEIDRYIREQIEMAGEAISIAVRNKISNGDTILTYGCSSLIEQILCEAWEAGLQFRT 549
L+ IDRY++E+I +A +AIS KISNGD IL YGCSSL+ +IL EAW G +FR
Sbjct: 299 ELRAAIDRYVQEKIVLAAQAISRFSYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRV 358
Query: 550 LVVGSRVSPDAAEMLRRLCARGLPCTYVDFTAVNYVMKTVSKXXXXXXXXXXXXXXXXXX 609
+VV SR + LR L G+P +Y+ A +YV+ VSK
Sbjct: 359 VVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRV 418
Query: 610 XXXXXXXXXXXXXXPVLVACHTHKFIDSLYTDAFMHNQIGDPDDLLEKSDDNSPLKDWRS 669
PVLV C T+KF + + TDAF+ N++ DPDDL K ++ L +W++
Sbjct: 419 GTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQN 478
Query: 670 NLNLTPLNLTYDVTPPCLITAVVTELAILPCTSAPVVLRFKLSE 713
+ L LNL YDVTPP L+ V+TEL ++PC+S PVVLR K S+
Sbjct: 479 HALLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSD 522
>X95648-1|CAA64950.1| 305|Homo sapiens eIF-2B protein.
Length = 305
Score = 60.5 bits (140), Expect = 2e-08
Identities = 67/264 (25%), Positives = 104/264 (39%), Gaps = 11/264 (4%)
Query: 436 KTEFSRGLESHLASSLEFLWTTREPCASQINAVKFFRH-HLAQLPNNVDEFDAKKTLQEE 494
K E +GL ++L S++E L A F R LA L + D KK + E
Sbjct: 38 KGETIQGLRANLTSAIETLCGVDSSVAVSSGGELFLRFISLASLEYS-DYSKCKKIMIER 96
Query: 495 IDRYIREQIEMAGEAISIAVRNKISNGDTILTYGCSSLIEQILCEAWEAGLQFRTLVVGS 554
+ ++R +I ++ I+ I +G TILT+ S ++ ++L A A +F V S
Sbjct: 97 GELFLR-RISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTES 155
Query: 555 RVSPDAAEMLRRLCARGLPCTYVDFTAVNYVMKTVSKXXXXXXXXXXXXXXXXXXXXXXX 614
+ +M + LC +P T V AV Y+M+
Sbjct: 156 QPDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQM 215
Query: 615 XXXXXXXXXPVLVACHTHKFIDSLYTDAFMHNQIGDPDDLLEKSDDNSPLKDWRSNLNLT 674
P V + KF+ F NQ PD K+D LK ++ +L
Sbjct: 216 AVCAKAQNKPFYVVAESFKFV-----RLFPLNQQDVPDKFKYKAD---TLKVAQTGQDLK 267
Query: 675 PLNLTYDVTPPCLITAVVTELAIL 698
+ D T P LIT + T+L +L
Sbjct: 268 EEHPWVDYTAPSLITLLFTDLGVL 291
>CR456831-1|CAG33112.1| 305|Homo sapiens EIF2B1 protein.
Length = 305
Score = 60.5 bits (140), Expect = 2e-08
Identities = 67/264 (25%), Positives = 104/264 (39%), Gaps = 11/264 (4%)
Query: 436 KTEFSRGLESHLASSLEFLWTTREPCASQINAVKFFRH-HLAQLPNNVDEFDAKKTLQEE 494
K E +GL ++L S++E L A F R LA L + D KK + E
Sbjct: 38 KGETIQGLRANLTSAIETLCGVDSSVAVSSGGELFLRFISLASLEYS-DYSKCKKIMIER 96
Query: 495 IDRYIREQIEMAGEAISIAVRNKISNGDTILTYGCSSLIEQILCEAWEAGLQFRTLVVGS 554
+ ++R +I ++ I+ I +G TILT+ S ++ ++L A A +F V S
Sbjct: 97 GELFLR-RISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTES 155
Query: 555 RVSPDAAEMLRRLCARGLPCTYVDFTAVNYVMKTVSKXXXXXXXXXXXXXXXXXXXXXXX 614
+ +M + LC +P T V AV Y+M+
Sbjct: 156 QPDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQM 215
Query: 615 XXXXXXXXXPVLVACHTHKFIDSLYTDAFMHNQIGDPDDLLEKSDDNSPLKDWRSNLNLT 674
P V + KF+ F NQ PD K+D LK ++ +L
Sbjct: 216 AVCAKAQNKPFYVVAESFKFV-----RLFPLNQQDVPDKFKYKAD---TLKVAQTGQDLK 267
Query: 675 PLNLTYDVTPPCLITAVVTELAIL 698
+ D T P LIT + T+L +L
Sbjct: 268 EEHPWVDYTAPSLITLLFTDLGVL 291
>BC104189-1|AAI04190.1| 305|Homo sapiens eukaryotic translation
initiation factor 2B, subunit 1 alpha, 26kDa protein.
Length = 305
Score = 60.5 bits (140), Expect = 2e-08
Identities = 67/264 (25%), Positives = 104/264 (39%), Gaps = 11/264 (4%)
Query: 436 KTEFSRGLESHLASSLEFLWTTREPCASQINAVKFFRH-HLAQLPNNVDEFDAKKTLQEE 494
K E +GL ++L S++E L A F R LA L + D KK + E
Sbjct: 38 KGETIQGLRANLTSAIETLCGVDSSVAVSSGGELFLRFISLASLEYS-DYSKCKKIMIER 96
Query: 495 IDRYIREQIEMAGEAISIAVRNKISNGDTILTYGCSSLIEQILCEAWEAGLQFRTLVVGS 554
+ ++R +I ++ I+ I +G TILT+ S ++ ++L A A +F V S
Sbjct: 97 GELFLR-RISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTES 155
Query: 555 RVSPDAAEMLRRLCARGLPCTYVDFTAVNYVMKTVSKXXXXXXXXXXXXXXXXXXXXXXX 614
+ +M + LC +P T V AV Y+M+
Sbjct: 156 QPDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQM 215
Query: 615 XXXXXXXXXPVLVACHTHKFIDSLYTDAFMHNQIGDPDDLLEKSDDNSPLKDWRSNLNLT 674
P V + KF+ F NQ PD K+D LK ++ +L
Sbjct: 216 AVCAKAQNKPFYVVAESFKFV-----RLFPLNQQDVPDKFKYKAD---TLKVAQTGQDLK 267
Query: 675 PLNLTYDVTPPCLITAVVTELAIL 698
+ D T P LIT + T+L +L
Sbjct: 268 EEHPWVDYTAPSLITLLFTDLGVL 291
>BC104188-1|AAI04189.1| 305|Homo sapiens eukaryotic translation
initiation factor 2B, subunit 1 alpha, 26kDa protein.
Length = 305
Score = 60.5 bits (140), Expect = 2e-08
Identities = 67/264 (25%), Positives = 104/264 (39%), Gaps = 11/264 (4%)
Query: 436 KTEFSRGLESHLASSLEFLWTTREPCASQINAVKFFRH-HLAQLPNNVDEFDAKKTLQEE 494
K E +GL ++L S++E L A F R LA L + D KK + E
Sbjct: 38 KGETIQGLRANLTSAIETLCGVDSSVAVSSGGELFLRFISLASLEYS-DYSKCKKIMIER 96
Query: 495 IDRYIREQIEMAGEAISIAVRNKISNGDTILTYGCSSLIEQILCEAWEAGLQFRTLVVGS 554
+ ++R +I ++ I+ I +G TILT+ S ++ ++L A A +F V S
Sbjct: 97 GELFLR-RISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTES 155
Query: 555 RVSPDAAEMLRRLCARGLPCTYVDFTAVNYVMKTVSKXXXXXXXXXXXXXXXXXXXXXXX 614
+ +M + LC +P T V AV Y+M+
Sbjct: 156 QPDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQM 215
Query: 615 XXXXXXXXXPVLVACHTHKFIDSLYTDAFMHNQIGDPDDLLEKSDDNSPLKDWRSNLNLT 674
P V + KF+ F NQ PD K+D LK ++ +L
Sbjct: 216 AVCAKAQNKPFYVVAESFKFV-----RLFPLNQQDVPDKFKYKAD---TLKVAQTGQDLK 267
Query: 675 PLNLTYDVTPPCLITAVVTELAIL 698
+ D T P LIT + T+L +L
Sbjct: 268 EEHPWVDYTAPSLITLLFTDLGVL 291
>BC103763-1|AAI03764.1| 305|Homo sapiens eukaryotic translation
initiation factor 2B, subunit 1 alpha, 26kDa protein.
Length = 305
Score = 60.5 bits (140), Expect = 2e-08
Identities = 67/264 (25%), Positives = 104/264 (39%), Gaps = 11/264 (4%)
Query: 436 KTEFSRGLESHLASSLEFLWTTREPCASQINAVKFFRH-HLAQLPNNVDEFDAKKTLQEE 494
K E +GL ++L S++E L A F R LA L + D KK + E
Sbjct: 38 KGETIQGLRANLTSAIETLCGVDSSVAVSSGGELFLRFISLASLEYS-DYSKCKKIMIER 96
Query: 495 IDRYIREQIEMAGEAISIAVRNKISNGDTILTYGCSSLIEQILCEAWEAGLQFRTLVVGS 554
+ ++R +I ++ I+ I +G TILT+ S ++ ++L A A +F V S
Sbjct: 97 GELFLR-RISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTES 155
Query: 555 RVSPDAAEMLRRLCARGLPCTYVDFTAVNYVMKTVSKXXXXXXXXXXXXXXXXXXXXXXX 614
+ +M + LC +P T V AV Y+M+
Sbjct: 156 QPDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQM 215
Query: 615 XXXXXXXXXPVLVACHTHKFIDSLYTDAFMHNQIGDPDDLLEKSDDNSPLKDWRSNLNLT 674
P V + KF+ F NQ PD K+D LK ++ +L
Sbjct: 216 AVCAKAQNKPFYVVAESFKFV-----RLFPLNQQDVPDKFKYKAD---TLKVAQTGQDLK 267
Query: 675 PLNLTYDVTPPCLITAVVTELAIL 698
+ D T P LIT + T+L +L
Sbjct: 268 EEHPWVDYTAPSLITLLFTDLGVL 291
>AF218009-1|AAG17251.1| 229|Homo sapiens unknown protein.
Length = 229
Score = 60.5 bits (140), Expect = 2e-08
Identities = 33/66 (50%), Positives = 45/66 (68%), Gaps = 4/66 (6%)
Query: 373 FQHLYTEFDKNPLKK---IPINSNLHPAIVKLGVQLSSRVVKGSNARCIALLDALNKMVR 429
F HL +N L + IP +S +HPA+V+LG+Q S +V GSNARCIALL AL ++++
Sbjct: 165 FSHLPQYSRQNSLTQFMSIP-SSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQ 223
Query: 430 DYVLPA 435
DY PA
Sbjct: 224 DYTTPA 229
>L02320-1|AAA36541.1| 583|Homo sapiens radixin protein.
Length = 583
Score = 31.9 bits (69), Expect = 8.1
Identities = 15/50 (30%), Positives = 27/50 (54%)
Query: 251 KEDDSVKQNEDMTVKDVVETLKNIVSVAKEVNEITTKVSALDLGGKKQEE 300
KE + ++ + K + +KN +A E+ E T K++ L+ KK+EE
Sbjct: 391 KERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEE 440
>BC047109-1|AAH47109.1| 583|Homo sapiens radixin protein.
Length = 583
Score = 31.9 bits (69), Expect = 8.1
Identities = 15/50 (30%), Positives = 27/50 (54%)
Query: 251 KEDDSVKQNEDMTVKDVVETLKNIVSVAKEVNEITTKVSALDLGGKKQEE 300
KE + ++ + K + +KN +A E+ E T K++ L+ KK+EE
Sbjct: 391 KERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEE 440
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.316 0.131 0.377
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 79,013,937
Number of Sequences: 224733
Number of extensions: 2629604
Number of successful extensions: 5841
Number of sequences better than 10.0: 18
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 5808
Number of HSP's gapped (non-prelim): 18
length of query: 716
length of database: 73,234,838
effective HSP length: 95
effective length of query: 621
effective length of database: 51,885,203
effective search space: 32220711063
effective search space used: 32220711063
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.6 bits)
S2: 69 (31.9 bits)
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