Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002700-TA|BGIBMGA002700-PA|IPR008266|Tyrosine protein
kinase, active site, IPR000719|Protein kinase, IPR001245|Tyrosine
protein kinase, IPR002290|Serine/threonine protein kinase,
IPR011009|Protein kinase-like
(266 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_UPI0000DB74F2 Cluster: PREDICTED: similar to Derailed 2... 248 1e-64
UniRef50_Q4RH14 Cluster: Chromosome undetermined SCAF15074, whol... 242 7e-63
UniRef50_P34925 Cluster: Tyrosine-protein kinase RYK precursor; ... 242 7e-63
UniRef50_UPI00015B55E2 Cluster: PREDICTED: similar to tyrosine-p... 239 4e-62
UniRef50_Q16VL6 Cluster: Tyrosine-protein kinase; n=1; Aedes aeg... 233 3e-60
UniRef50_UPI0000E48358 Cluster: PREDICTED: hypothetical protein;... 230 3e-59
UniRef50_Q17PG3 Cluster: Tyrosine-protein kinase drl; n=5; Endop... 225 7e-58
UniRef50_Q9V422 Cluster: Tyrosine-protein kinase Dnt precursor; ... 217 2e-55
UniRef50_Q27324 Cluster: Tyrosine-protein kinase Drl precursor; ... 214 2e-54
UniRef50_Q7JQT0 Cluster: GH27039p; n=4; Diptera|Rep: GH27039p - ... 205 1e-51
UniRef50_UPI00015B55E4 Cluster: PREDICTED: similar to receptor-l... 185 1e-45
UniRef50_Q9XZ66 Cluster: Tyrosine kinase receptor-related protei... 182 6e-45
UniRef50_P79950 Cluster: Tyrosine kinase receptor; n=3; Xenopus|... 166 6e-40
UniRef50_P23049 Cluster: Tyrosine-protein kinase transforming pr... 160 3e-38
UniRef50_P08581 Cluster: Hepatocyte growth factor receptor precu... 156 6e-37
UniRef50_Q9YGM5 Cluster: Plasminogen related growth factor recep... 152 8e-36
UniRef50_Q64GK4 Cluster: C-Met receptor tyrosine kinase; n=9; Cl... 152 8e-36
UniRef50_Q6DTW4 Cluster: Tyrosine kinase receptor ron; n=6; Eume... 151 1e-35
UniRef50_Q04912 Cluster: Macrophage-stimulating protein receptor... 151 2e-35
UniRef50_Q70W11 Cluster: Receptor tyrosine kinase X; n=1; Ciona ... 145 1e-33
UniRef50_P30530 Cluster: Tyrosine-protein kinase receptor UFO pr... 145 1e-33
UniRef50_Q4SR43 Cluster: Chromosome 11 SCAF14528, whole genome s... 143 5e-33
UniRef50_Q008W6 Cluster: Gamma-carboxyglutamic acid protein 1; n... 142 1e-32
UniRef50_Q9Y1Y9 Cluster: Protein tyrosine kinase; n=3; Metazoa|R... 141 2e-32
UniRef50_P06213 Cluster: Insulin receptor precursor (EC 2.7.10.1... 141 2e-32
UniRef50_O97191 Cluster: Tyrosine-protein kinase receptor; n=1; ... 140 4e-32
UniRef50_UPI0000D55DFF Cluster: PREDICTED: similar to Insulin-li... 139 6e-32
UniRef50_O73798 Cluster: Insulin-like growth factor 1 receptor p... 139 6e-32
UniRef50_P00522 Cluster: Tyrosine-protein kinase Abl; n=5; Eumet... 138 1e-31
UniRef50_Q25410 Cluster: Putative molluscan insulin-related pept... 137 3e-31
UniRef50_Q7Q0F6 Cluster: Tyrosine-protein kinase receptor; n=2; ... 136 5e-31
UniRef50_Q9PVZ4 Cluster: Insulin receptor precursor (EC 2.7.10.1... 136 5e-31
UniRef50_UPI0000DB6DD4 Cluster: PREDICTED: similar to Insulin-li... 136 7e-31
UniRef50_UPI0000D57494 Cluster: PREDICTED: similar to insulin re... 136 7e-31
UniRef50_Q4RXB0 Cluster: Chromosome 11 SCAF14979, whole genome s... 135 1e-30
UniRef50_P08069 Cluster: Insulin-like growth factor 1 receptor p... 135 1e-30
UniRef50_P08922 Cluster: Proto-oncogene tyrosine-protein kinase ... 134 2e-30
UniRef50_UPI0000519AF4 Cluster: PREDICTED: similar to Abl tyrosi... 134 2e-30
UniRef50_Q4H3B8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 134 2e-30
UniRef50_UPI00015B4B0F Cluster: PREDICTED: similar to proto-onco... 134 3e-30
UniRef50_Q7PWP1 Cluster: ENSANGP00000013218; n=2; Culicidae|Rep:... 133 5e-30
UniRef50_Q52V39 Cluster: Tyrosine-protein kinase receptor; n=2; ... 133 5e-30
UniRef50_Q2LC18 Cluster: Tyrosine-protein kinase receptor; n=2; ... 133 5e-30
UniRef50_UPI00015B5959 Cluster: PREDICTED: similar to insulin re... 132 7e-30
UniRef50_Q5K4G5 Cluster: Receptor tyrosine kinase; n=1; Suberite... 131 2e-29
UniRef50_P00521 Cluster: Tyrosine-protein kinase transforming pr... 131 2e-29
UniRef50_Q6ZMQ8-3 Cluster: Isoform 3 of Q6ZMQ8 ; n=6; Tetrapoda|... 131 2e-29
UniRef50_Q70W09 Cluster: Receptor tyrosine kinase VIII; n=1; Cio... 131 2e-29
UniRef50_Q6ZMQ8 Cluster: Serine/threonine-protein kinase LMTK1; ... 131 2e-29
UniRef50_P10447 Cluster: Tyrosine-protein kinase transforming pr... 130 4e-29
UniRef50_P00519 Cluster: Proto-oncogene tyrosine-protein kinase ... 130 4e-29
UniRef50_UPI0000D57520 Cluster: PREDICTED: similar to CG8250-PA;... 130 5e-29
UniRef50_P42684 Cluster: Tyrosine-protein kinase ABL2; n=38; Eut... 130 5e-29
UniRef50_Q7YT64 Cluster: Tyrosine-protein kinase receptor; n=1; ... 129 6e-29
UniRef50_UPI00015B51DA Cluster: PREDICTED: similar to ENSANGP000... 129 8e-29
UniRef50_P03949 Cluster: Tyrosine-protein kinase abl-1; n=5; Cae... 129 8e-29
UniRef50_P00529 Cluster: Tyrosine-protein kinase transforming pr... 128 1e-28
UniRef50_UPI00004D7E5F Cluster: Proto-oncogene tyrosine-protein ... 128 1e-28
UniRef50_Q8WRF4 Cluster: Receptor tyrosine kinase; n=1; Monosiga... 128 1e-28
UniRef50_A7RHT9 Cluster: Predicted protein; n=1; Nematostella ve... 128 1e-28
UniRef50_Q4RWP2 Cluster: Tyrosine-protein kinase receptor; n=1; ... 127 3e-28
UniRef50_Q16620 Cluster: BDNF/NT-3 growth factors receptor precu... 127 3e-28
UniRef50_Q91987 Cluster: BDNF/NT-3 growth factors receptor precu... 127 3e-28
UniRef50_Q170Z1 Cluster: Tyrosine-protein kinase receptor; n=1; ... 126 4e-28
UniRef50_Q06418 Cluster: Tyrosine-protein kinase receptor TYRO3 ... 126 4e-28
UniRef50_UPI0000EB1EAB Cluster: Serine/threonine-protein kinase ... 126 8e-28
UniRef50_Q4SQ93 Cluster: Tyrosine-protein kinase receptor; n=2; ... 126 8e-28
UniRef50_Q3TJ05 Cluster: 14 days pregnant adult female placenta ... 126 8e-28
UniRef50_Q9XVQ7 Cluster: Putative uncharacterized protein; n=2; ... 126 8e-28
UniRef50_Q9U5A8 Cluster: Insulin receptor-like protein precursor... 126 8e-28
UniRef50_Q8JG38 Cluster: Fibroblast growth factor receptor 2 pre... 126 8e-28
UniRef50_UPI0000E47617 Cluster: PREDICTED: similar to muscle spe... 125 1e-27
UniRef50_UPI0000E47068 Cluster: PREDICTED: similar to tyrosine p... 125 1e-27
UniRef50_UPI0000DB7F8D Cluster: PREDICTED: similar to Cad96Ca CG... 125 1e-27
UniRef50_A3EXK5 Cluster: Fibroblast growth factor receptor b; n=... 125 1e-27
UniRef50_Q59F30 Cluster: Fibroblast growth factor receptor 4 var... 125 1e-27
UniRef50_P11362 Cluster: Basic fibroblast growth factor receptor... 125 1e-27
UniRef50_A7SL46 Cluster: Predicted protein; n=2; Eumetazoa|Rep: ... 125 1e-27
UniRef50_Q93105 Cluster: Insulin-like receptor precursor (EC 2.7... 124 2e-27
UniRef50_Q9Y1Y5 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 124 2e-27
UniRef50_P35590 Cluster: Tyrosine-protein kinase receptor Tie-1 ... 124 2e-27
UniRef50_Q03142 Cluster: Fibroblast growth factor receptor 4 pre... 124 2e-27
UniRef50_O76148 Cluster: Tyrosine-protein kinase receptor; n=1; ... 124 3e-27
UniRef50_P09208 Cluster: Insulin-like receptor precursor (EC 2.7... 124 3e-27
UniRef50_Q86PM4 Cluster: Fibroblast growth factor receptor precu... 124 3e-27
UniRef50_Q7YZH7 Cluster: MBRTK2; n=1; Monosiga brevicollis|Rep: ... 123 4e-27
UniRef50_Q7YXV8 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 123 4e-27
UniRef50_Q24488 Cluster: Tyrosine-protein kinase transmembrane r... 123 4e-27
UniRef50_Q8INU0 Cluster: CG14396-PD, isoform D; n=10; Sophophora... 123 5e-27
UniRef50_Q7Z1L9 Cluster: Neurite outgrowth regulated kinase; n=1... 123 5e-27
UniRef50_Q1JUB8 Cluster: Fibroblast growth factor receptor; n=2;... 123 5e-27
UniRef50_O15146 Cluster: Muscle, skeletal receptor tyrosine prot... 123 5e-27
UniRef50_P22182 Cluster: Fibroblast growth factor receptor 1 pre... 123 5e-27
UniRef50_Q4TBR4 Cluster: Chromosome undetermined SCAF7099, whole... 122 9e-27
UniRef50_Q5TUS8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 122 9e-27
UniRef50_A6NNJ8 Cluster: Uncharacterized protein LTK; n=12; Euar... 122 9e-27
UniRef50_Q8AXY6 Cluster: Muscle, skeletal receptor tyrosine prot... 122 9e-27
UniRef50_UPI00015B5971 Cluster: PREDICTED: similar to leukocyte ... 122 1e-26
UniRef50_Q674V1 Cluster: Vascular endothelial growth factor rece... 122 1e-26
UniRef50_Q8IXC7 Cluster: Isoform of FGFR2; n=23; Euteleostomi|Re... 122 1e-26
UniRef50_Q9YI66 Cluster: Developmental receptor tyrosine kinase;... 121 2e-26
UniRef50_Q5DM52 Cluster: Receptor tyrosine kinase Torso-like pro... 121 2e-26
UniRef50_Q12866 Cluster: Proto-oncogene tyrosine-protein kinase ... 121 2e-26
UniRef50_P14616 Cluster: Insulin receptor-related protein precur... 121 2e-26
UniRef50_UPI0000DB6D22 Cluster: PREDICTED: similar to Alk CG8250... 120 3e-26
UniRef50_UPI0000D57699 Cluster: PREDICTED: similar to CG18247-PA... 120 3e-26
UniRef50_P04629 Cluster: High affinity nerve growth factor recep... 120 3e-26
UniRef50_P13368 Cluster: Protein sevenless; n=20; Eumetazoa|Rep:... 120 3e-26
UniRef50_A7RZ71 Cluster: Predicted protein; n=1; Nematostella ve... 120 4e-26
UniRef50_A3EXK4 Cluster: Fibroblast growth factor receptor a; n=... 120 4e-26
UniRef50_Q25197 Cluster: Putative insulin-like peptide receptor ... 120 4e-26
UniRef50_Q10656-2 Cluster: Isoform b of Q10656 ; n=4; Caenorhabd... 120 5e-26
UniRef50_Q25177 Cluster: Receptor protein-tyrosine kinase; n=2; ... 120 5e-26
UniRef50_Q07407 Cluster: Fibroblast growth factor receptor homol... 120 5e-26
UniRef50_Q10656 Cluster: Myoblast growth factor receptor egl-15 ... 120 5e-26
UniRef50_UPI0000D55449 Cluster: PREDICTED: similar to CG7223-PA,... 119 7e-26
UniRef50_Q52ZF0 Cluster: Receptor tyrosine kinase-like protein; ... 119 7e-26
UniRef50_Q16XX9 Cluster: Tyrosine-protein kinase shark; n=2; Cul... 119 7e-26
UniRef50_A7RGW8 Cluster: Predicted protein; n=1; Nematostella ve... 119 9e-26
UniRef50_UPI0000E471D0 Cluster: PREDICTED: similar to p80 protei... 118 1e-25
UniRef50_Q4S1S8 Cluster: Chromosome undetermined SCAF14764, whol... 118 1e-25
UniRef50_Q4RJ67 Cluster: Chromosome 1 SCAF15039, whole genome sh... 118 1e-25
UniRef50_A7RVU0 Cluster: Predicted protein; n=1; Nematostella ve... 118 1e-25
UniRef50_Q2VJ45 Cluster: HOOK3-RET fusion protein; n=3; Eutheria... 118 1e-25
UniRef50_P07949 Cluster: Proto-oncogene tyrosine-protein kinase ... 118 1e-25
UniRef50_UPI0000DB6C99 Cluster: PREDICTED: similar to proto-onco... 118 2e-25
UniRef50_Q7KJ08 Cluster: Receptor protein tyrosine kinase ALK sp... 118 2e-25
UniRef50_O76978 Cluster: Tyrosine kinase; n=1; Sycon raphanus|Re... 118 2e-25
UniRef50_UPI0000E49FB6 Cluster: PREDICTED: similar to RE05926p, ... 118 2e-25
UniRef50_Q5IJ68 Cluster: Trk-like receptor tyrosine kinase; n=1;... 118 2e-25
UniRef50_O76997 Cluster: Putative neurotrophin receptor LTRK 1 p... 118 2e-25
UniRef50_O02466 Cluster: Insulin-like peptide receptor precursor... 118 2e-25
UniRef50_UPI0000E48523 Cluster: PREDICTED: similar to protein-ty... 117 4e-25
UniRef50_Q9Y1Y6 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 117 4e-25
UniRef50_Q9NH62 Cluster: Tyrosine kinase 5; n=2; Schistosoma man... 117 4e-25
UniRef50_Q6R1Y3 Cluster: Src family kinase; n=6; Fungi/Metazoa g... 117 4e-25
UniRef50_Q17LF1 Cluster: Muscle-specific tyrosine kinase recepto... 117 4e-25
UniRef50_P08923 Cluster: Leukocyte tyrosine kinase receptor prec... 117 4e-25
UniRef50_UPI0000DB6B52 Cluster: PREDICTED: similar to Ror CG4926... 116 5e-25
UniRef50_Q4S351 Cluster: Chromosome 4 SCAF14752, whole genome sh... 116 5e-25
UniRef50_Q9Y1Y7 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 116 5e-25
UniRef50_Q9Y1X7 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 116 5e-25
UniRef50_Q7Q5T3 Cluster: Tyrosine-protein kinase receptor; n=3; ... 116 5e-25
UniRef50_Q70DV1 Cluster: Src tyrosine kinase; n=1; Schistosoma m... 116 5e-25
UniRef50_Q02763 Cluster: Angiopoietin-1 receptor precursor; n=41... 116 5e-25
UniRef50_Q26614 Cluster: Fibroblast growth factor receptor precu... 116 5e-25
UniRef50_Q7YZW6 Cluster: Putative uncharacterized protein; n=3; ... 116 6e-25
UniRef50_Q16RK6 Cluster: Receptor protein tyrosine kinase; n=1; ... 116 6e-25
UniRef50_A6P4V4 Cluster: Tyrosine-protein kinase receptor; n=2; ... 116 6e-25
UniRef50_Q9UM73 Cluster: ALK tyrosine kinase receptor precursor;... 116 6e-25
UniRef50_UPI00015B4CAE Cluster: PREDICTED: similar to ENSANGP000... 116 8e-25
UniRef50_Q5I4E2 Cluster: Bm-DAF-2 precursor; n=1; Brugia malayi|... 116 8e-25
UniRef50_P43403 Cluster: Tyrosine-protein kinase ZAP-70; n=55; E... 116 8e-25
UniRef50_P16591 Cluster: Proto-oncogene tyrosine-protein kinase ... 116 8e-25
UniRef50_UPI00015B6133 Cluster: PREDICTED: similar to protein ty... 115 1e-24
UniRef50_Q9GRH1 Cluster: Tyrosine-protein kinase receptor; n=4; ... 115 1e-24
UniRef50_Q95YD4 Cluster: Protein kinase protein 32, isoform a; n... 115 1e-24
UniRef50_Q7PYY7 Cluster: ENSANGP00000019144; n=1; Anopheles gamb... 115 1e-24
UniRef50_UPI00015B4DC3 Cluster: PREDICTED: similar to receptor t... 115 1e-24
UniRef50_Q4S8H3 Cluster: Chromosome 2 SCAF14705, whole genome sh... 115 1e-24
UniRef50_A7RNB1 Cluster: Predicted protein; n=1; Nematostella ve... 115 1e-24
UniRef50_Q2VXS7 Cluster: Proto-oncogene c-fes variant 4; n=77; E... 115 1e-24
UniRef50_Q4SK07 Cluster: Tyrosine-protein kinase receptor; n=2; ... 114 2e-24
UniRef50_Q01974 Cluster: Tyrosine-protein kinase transmembrane r... 114 2e-24
UniRef50_UPI0000F2052A Cluster: PREDICTED: similar to anaplastic... 114 3e-24
UniRef50_Q17J18 Cluster: Tyrosine-protein kinase; n=4; Endoptery... 114 3e-24
UniRef50_O76385 Cluster: Putative uncharacterized protein; n=3; ... 114 3e-24
UniRef50_P29317 Cluster: Ephrin type-A receptor 2 precursor; n=3... 114 3e-24
UniRef50_Q1HTP2 Cluster: Tyrosine-protein kinase receptor; n=4; ... 113 3e-24
UniRef50_A7S4Y9 Cluster: Predicted protein; n=1; Nematostella ve... 113 3e-24
UniRef50_P42685 Cluster: Tyrosine-protein kinase FRK; n=27; Fung... 113 3e-24
UniRef50_A7SFD8 Cluster: Predicted protein; n=2; Nematostella ve... 113 4e-24
UniRef50_Q8MY85 Cluster: Fibroblast growth factor receptor 2 pre... 113 4e-24
UniRef50_Q4H3M5 Cluster: Ephrin receptor; n=1; Ciona intestinali... 113 6e-24
UniRef50_Q8NFA8 Cluster: Transmembrane receptor PTK7-2; n=18; Eu... 113 6e-24
UniRef50_Q13308 Cluster: Tyrosine-protein kinase-like 7 precurso... 113 6e-24
UniRef50_P21709 Cluster: Ephrin type-A receptor 1 precursor; n=1... 113 6e-24
UniRef50_Q09147 Cluster: Fibroblast growth factor receptor homol... 112 8e-24
UniRef50_UPI0000D5603D Cluster: PREDICTED: similar to Insulin re... 112 1e-23
UniRef50_Q9Y1Y2 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 112 1e-23
UniRef50_Q9Y1X8 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 112 1e-23
UniRef50_Q9BL77 Cluster: C-terminal src kinase protein 1; n=2; C... 112 1e-23
UniRef50_Q7YZX2 Cluster: Bruton's tyrosine kinase-like protein; ... 112 1e-23
UniRef50_Q9I9L1 Cluster: Arg protein-tyrosine kinase; n=12; Tetr... 111 1e-23
UniRef50_Q8JFV0 Cluster: Tyrosine-protein kinase receptor; n=5; ... 111 1e-23
UniRef50_P04412 Cluster: Epidermal growth factor receptor precur... 111 1e-23
UniRef50_UPI0000F1D883 Cluster: PREDICTED: hypothetical protein;... 111 2e-23
UniRef50_UPI0000E47A46 Cluster: PREDICTED: similar to ret protei... 111 2e-23
UniRef50_UPI0000D569CE Cluster: PREDICTED: similar to CG10023-PA... 111 2e-23
UniRef50_Q98TD0 Cluster: Ephrin receptor; n=6; Amniota|Rep: Ephr... 111 2e-23
UniRef50_Q8WPV5 Cluster: Tyrosine kinase; n=2; Eumetazoa|Rep: Ty... 111 2e-23
UniRef50_Q9VBW3 Cluster: Tyrosine kinase receptor Cad96Ca precur... 111 2e-23
UniRef50_UPI0000D57178 Cluster: PREDICTED: similar to CG14396-PA... 111 2e-23
UniRef50_Q95ZV7 Cluster: Putative uncharacterized protein; n=3; ... 111 2e-23
UniRef50_Q9V6K3 Cluster: Tyrosine-protein kinase transmembrane r... 111 2e-23
UniRef50_P24348 Cluster: Receptor tyrosine-protein kinase let-23... 111 2e-23
UniRef50_P08631 Cluster: Tyrosine-protein kinase HCK; n=32; Eute... 111 2e-23
UniRef50_UPI00015A3FB5 Cluster: hypothetical protein LOC553690; ... 110 3e-23
UniRef50_Q4SII9 Cluster: Chromosome 5 SCAF14581, whole genome sh... 110 3e-23
UniRef50_Q8T6F8 Cluster: SRC-1; n=3; Caenorhabditis|Rep: SRC-1 -... 110 3e-23
UniRef50_P42686 Cluster: Tyrosine-protein kinase isoform SRK1; n... 110 4e-23
UniRef50_P21860 Cluster: Receptor tyrosine-protein kinase erbB-3... 110 4e-23
UniRef50_Q4L0H7 Cluster: Insulin receptor tyrosine kinase; n=2; ... 109 5e-23
UniRef50_A7SAX2 Cluster: Predicted protein; n=3; Nematostella ve... 109 5e-23
UniRef50_Q9H3Y6 Cluster: Tyrosine-protein kinase Srms; n=17; Amn... 109 5e-23
UniRef50_UPI0000D577C3 Cluster: PREDICTED: similar to CG8874-PB,... 109 7e-23
UniRef50_Q9GRH2 Cluster: Tyrosine-protein kinase receptor; n=1; ... 109 7e-23
UniRef50_Q9BKL8 Cluster: Tyrosine-protein kinase receptor; n=2; ... 109 7e-23
UniRef50_Q9BLY1 Cluster: Receptor tyrosine kinase; n=5; Caenorha... 109 9e-23
UniRef50_Q7Z1D3 Cluster: Focal adhesion kinase; n=1; Lytechinus ... 109 9e-23
UniRef50_Q24145 Cluster: Tyrosine-protein kinase shark; n=2; Sop... 109 9e-23
UniRef50_P09619 Cluster: Beta-type platelet-derived growth facto... 109 9e-23
UniRef50_P53356 Cluster: Tyrosine-protein kinase HTK16; n=1; Hyd... 109 9e-23
UniRef50_P18106 Cluster: Tyrosine-protein kinase Fps85D; n=12; E... 109 9e-23
UniRef50_Q4H3M7 Cluster: Ephrin receptor; n=3; Ciona|Rep: Ephrin... 108 1e-22
UniRef50_Q179Z3 Cluster: Tyrosine-protein kinase; n=1; Aedes aeg... 108 1e-22
UniRef50_A7SE14 Cluster: Predicted protein; n=4; Nematostella ve... 108 1e-22
UniRef50_Q96Q04 Cluster: Serine/threonine-protein kinase LMTK3 p... 108 1e-22
UniRef50_P04626 Cluster: Receptor tyrosine-protein kinase erbB-2... 108 1e-22
UniRef50_Q4SWL0 Cluster: Ephrin receptor; n=3; Tetraodontidae|Re... 108 2e-22
UniRef50_Q1HTP1 Cluster: Tyrosine-protein kinase receptor; n=1; ... 108 2e-22
UniRef50_Q9TX48 Cluster: 220 kDa ABL-related protein tyrosine ki... 108 2e-22
UniRef50_P00528 Cluster: Tyrosine-protein kinase Src64B; n=6; En... 108 2e-22
UniRef50_Q5TRF2 Cluster: ENSANGP00000025511; n=1; Anopheles gamb... 107 2e-22
UniRef50_P79749 Cluster: Beta-type platelet-derived growth facto... 107 2e-22
UniRef50_Q66I04 Cluster: Zgc:92124; n=1; Danio rerio|Rep: Zgc:92... 107 3e-22
UniRef50_P18475 Cluster: Tyrosine-protein kinase receptor torso ... 107 3e-22
UniRef50_Q9Y1Y3 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 107 4e-22
UniRef50_Q7QAK4 Cluster: ENSANGP00000020257; n=1; Anopheles gamb... 107 4e-22
UniRef50_Q17JW1 Cluster: Tyrosine protein kinase; n=2; Culicidae... 107 4e-22
UniRef50_P00534 Cluster: Tyrosine-protein kinase transforming pr... 107 4e-22
UniRef50_Q6SAW1 Cluster: Epidermal growth factor receptor; n=70;... 106 5e-22
UniRef50_UPI00015A7C25 Cluster: UPI00015A7C25 related cluster; n... 106 7e-22
UniRef50_Q17IF1 Cluster: Receptor protein tyrosine kinase; n=1; ... 106 7e-22
UniRef50_P07947 Cluster: Proto-oncogene tyrosine-protein kinase ... 106 7e-22
UniRef50_Q15303 Cluster: Receptor tyrosine-protein kinase erbB-4... 106 7e-22
UniRef50_Q4SP88 Cluster: Ephrin receptor; n=2; Tetraodon nigrovi... 105 1e-21
UniRef50_Q8WSM2 Cluster: Receptor tyrosine kinase; n=1; Schistos... 105 1e-21
UniRef50_Q86LZ8 Cluster: Insulin receptor protein kinase; n=2; S... 105 1e-21
UniRef50_Q6TYB9 Cluster: Dauer abnormal formation-2 precursor; n... 105 1e-21
UniRef50_Q6SAJ2 Cluster: Epidermal growth factor receptor; n=11;... 105 1e-21
UniRef50_Q4H2M8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 105 1e-21
UniRef50_O76809 Cluster: Receptor tyrosine kinase HTK30; n=1; Hy... 105 1e-21
UniRef50_P00533 Cluster: Epidermal growth factor receptor precur... 105 1e-21
UniRef50_UPI0000E4736E Cluster: PREDICTED: similar to src-family... 105 2e-21
UniRef50_UPI0000E257E1 Cluster: PREDICTED: similar to tyrosine k... 105 2e-21
UniRef50_Q4RXA0 Cluster: Chromosome 11 SCAF14979, whole genome s... 105 2e-21
UniRef50_Q9Y1Z0 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 105 2e-21
UniRef50_Q9Y1X9 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 105 2e-21
UniRef50_Q16288 Cluster: NT-3 growth factor receptor precursor; ... 105 2e-21
UniRef50_Q9I8N6 Cluster: Macrophage colony-stimulating factor 1 ... 105 2e-21
UniRef50_Q8UVR8 Cluster: Macrophage colony-stimulating factor 1 ... 105 2e-21
UniRef50_Q4SC90 Cluster: Chromosome undetermined SCAF14659, whol... 104 2e-21
UniRef50_Q4RPK6 Cluster: Chromosome 12 SCAF15007, whole genome s... 104 2e-21
UniRef50_O77440 Cluster: Protein-tyrosine kinase HTK98; n=1; Hyd... 104 2e-21
UniRef50_Q01973 Cluster: Tyrosine-protein kinase transmembrane r... 104 2e-21
UniRef50_UPI000069DB6A Cluster: Ephrin type-A receptor 6 precurs... 104 3e-21
UniRef50_Q4SS18 Cluster: Chromosome undetermined SCAF14482, whol... 104 3e-21
UniRef50_Q0P4R9 Cluster: Discoidin domain receptor family, membe... 104 3e-21
UniRef50_Q17MF5 Cluster: Tyrosine-protein kinase; n=2; Culicidae... 104 3e-21
UniRef50_Q8IWU2 Cluster: Serine/threonine-protein kinase LMTK2 p... 104 3e-21
UniRef50_Q95YM9 Cluster: Fibroblast growth factor receptor precu... 104 3e-21
UniRef50_Q5RIU8 Cluster: Novel protein similar to vertebrate dis... 103 4e-21
UniRef50_Q4TEC1 Cluster: Chromosome undetermined SCAF5507, whole... 103 4e-21
UniRef50_Q13882 Cluster: Tyrosine-protein kinase 6; n=11; Mammal... 103 4e-21
UniRef50_Q8JFR5 Cluster: Mast/stem cell growth factor receptor p... 103 5e-21
UniRef50_UPI000065F6B2 Cluster: Receptor tyrosine-protein kinase... 103 6e-21
UniRef50_Q3TYD6 Cluster: Serine/threonine-protein kinase LMTK2 p... 103 6e-21
UniRef50_P36888 Cluster: FL cytokine receptor precursor; n=33; A... 103 6e-21
UniRef50_Q08345 Cluster: Epithelial discoidin domain-containing ... 103 6e-21
UniRef50_UPI0000D55B96 Cluster: PREDICTED: similar to Tyrosine-p... 102 8e-21
UniRef50_Q4T272 Cluster: Chromosome undetermined SCAF10323, whol... 102 8e-21
UniRef50_Q9U8U8 Cluster: VEGFR-like; n=1; Branchiostoma belcheri... 102 8e-21
UniRef50_Q8T0W6 Cluster: Putative insulin receptor precursor; n=... 102 8e-21
UniRef50_A7SZN9 Cluster: Predicted protein; n=3; Nematostella ve... 102 8e-21
UniRef50_A7RGV3 Cluster: Predicted protein; n=1; Nematostella ve... 102 8e-21
UniRef50_UPI0000E4A99A Cluster: PREDICTED: similar to tyrosine k... 102 1e-20
UniRef50_Q4RV12 Cluster: Ephrin receptor; n=2; Tetraodontidae|Re... 102 1e-20
UniRef50_Q70W12 Cluster: Discoidin receptor; n=1; Ciona intestin... 102 1e-20
UniRef50_Q573B4 Cluster: Proto-oncogene tyrosine-protein kinase ... 102 1e-20
UniRef50_UPI000069F079 Cluster: Serine/threonine-protein kinase ... 101 1e-20
UniRef50_UPI0000F306DC Cluster: Serine/threonine-protein kinase ... 101 1e-20
UniRef50_A4IIX3 Cluster: Putative uncharacterized protein; n=1; ... 101 1e-20
UniRef50_Q6PFV6 Cluster: Ephrin receptor; n=11; Tetrapoda|Rep: E... 101 1e-20
UniRef50_Q68KJ7 Cluster: HER2; n=3; Amniota|Rep: HER2 - Felis si... 101 1e-20
UniRef50_Q9Y1Y8 Cluster: Protein tyrosine kinase; n=2; Metazoa|R... 101 1e-20
UniRef50_Q22489 Cluster: Putative uncharacterized protein; n=4; ... 101 1e-20
UniRef50_O16131 Cluster: Insulin receptor homolog precursor; n=2... 101 1e-20
UniRef50_Q15516 Cluster: Tyrosine kinase; n=1; Homo sapiens|Rep:... 101 1e-20
UniRef50_Q8MY86 Cluster: Fibroblast growth factor receptor 1 pre... 101 1e-20
UniRef50_P54756 Cluster: Ephrin type-A receptor 5 precursor; n=1... 101 1e-20
UniRef50_UPI00015B6363 Cluster: PREDICTED: similar to tyrosine p... 101 2e-20
UniRef50_Q910A2 Cluster: Spleen protein tyrosine kinase; n=2; Da... 101 2e-20
UniRef50_Q4SQX3 Cluster: Chromosome 11 SCAF14528, whole genome s... 101 2e-20
UniRef50_Q9Y1Y1 Cluster: Protein tyrosine kinase; n=2; cellular ... 101 2e-20
UniRef50_Q19238 Cluster: Putative tyrosine-protein kinase F09A5.... 101 2e-20
UniRef50_P42679 Cluster: Megakaryocyte-associated tyrosine-prote... 101 2e-20
UniRef50_Q05397 Cluster: Focal adhesion kinase 1; n=111; Euteleo... 101 2e-20
UniRef50_UPI0000E468FC Cluster: PREDICTED: similar to KLG; n=3; ... 101 3e-20
UniRef50_UPI0000D576E5 Cluster: PREDICTED: similar to CG33531-PA... 101 3e-20
UniRef50_Q5G254 Cluster: Erbb3; n=6; Danio rerio|Rep: Erbb3 - Da... 101 3e-20
UniRef50_Q9V4E5 Cluster: CG1511-PC, isoform C; n=12; Diptera|Rep... 101 3e-20
UniRef50_Q6SAA3 Cluster: Epidermal growth factor receptor; n=39;... 101 3e-20
UniRef50_P17948 Cluster: Vascular endothelial growth factor rece... 101 3e-20
UniRef50_Q08BY6 Cluster: Zgc:153964; n=3; Danio rerio|Rep: Zgc:1... 100 3e-20
UniRef50_Q9U531 Cluster: Focal adhesion kinase homolog DFak56; n... 100 3e-20
UniRef50_A7SI92 Cluster: Predicted protein; n=2; Nematostella ve... 100 3e-20
UniRef50_Q16832 Cluster: Discoidin domain-containing receptor 2 ... 100 3e-20
UniRef50_UPI0000F1FB23 Cluster: PREDICTED: similar to tyrosine p... 100 4e-20
UniRef50_UPI0000DB7735 Cluster: PREDICTED: similar to Insulin re... 100 4e-20
UniRef50_UPI000051AB92 Cluster: PREDICTED: similar to Fak-like t... 100 4e-20
UniRef50_A2CG59 Cluster: Eph receptor B1; n=23; Euteleostomi|Rep... 100 4e-20
UniRef50_Q9VLQ8 Cluster: CG8222-PA, isoform A; n=8; Sophophora|R... 100 4e-20
UniRef50_Q8T4M0 Cluster: VEGFR-A splice form A; n=4; Diptera|Rep... 100 4e-20
UniRef50_P08630 Cluster: Tyrosine-protein kinase Btk29A; n=10; E... 100 4e-20
UniRef50_P51813 Cluster: Cytoplasmic tyrosine-protein kinase BMX... 100 4e-20
UniRef50_UPI0000D56EE8 Cluster: PREDICTED: similar to CG14992-PA... 99 6e-20
UniRef50_Q4SJQ3 Cluster: Tyrosine-protein kinase receptor; n=1; ... 99 6e-20
UniRef50_Q6VU50 Cluster: Eph receptor; n=3; Endopterygota|Rep: E... 99 6e-20
UniRef50_Q5BXN9 Cluster: SJCHGC05493 protein; n=1; Schistosoma j... 99 6e-20
UniRef50_P35916 Cluster: Vascular endothelial growth factor rece... 99 6e-20
UniRef50_P35968 Cluster: Vascular endothelial growth factor rece... 99 6e-20
UniRef50_P10721 Cluster: Mast/stem cell growth factor receptor p... 99 6e-20
UniRef50_P23458 Cluster: Tyrosine-protein kinase JAK1; n=55; Eut... 99 6e-20
UniRef50_P51451 Cluster: Tyrosine-protein kinase BLK; n=5; Eutel... 99 6e-20
UniRef50_P07333 Cluster: Macrophage colony-stimulating factor 1 ... 100 8e-20
UniRef50_UPI0000E47549 Cluster: PREDICTED: similar to Cek8; n=2;... 99 1e-19
UniRef50_Q640T5 Cluster: Tyrosine-protein kinase receptor; n=2; ... 99 1e-19
UniRef50_Q4SFJ9 Cluster: Chromosome 7 SCAF14601, whole genome sh... 99 1e-19
UniRef50_Q7YZH5 Cluster: MBTK3; n=1; Monosiga brevicollis|Rep: M... 99 1e-19
UniRef50_Q7YSY1 Cluster: Fes-like tyrosine kinase protein; n=1; ... 99 1e-19
UniRef50_Q6NP28 Cluster: LP09923p; n=6; Endopterygota|Rep: LP099... 99 1e-19
UniRef50_Q17C76 Cluster: Focal adhesion kinase; n=2; Culicidae|R... 99 1e-19
UniRef50_P16234 Cluster: Alpha-type platelet-derived growth fact... 99 1e-19
UniRef50_UPI0000F1EB7D Cluster: PREDICTED: hypothetical protein;... 99 1e-19
UniRef50_Q4RL31 Cluster: Chromosome undetermined SCAF15024, whol... 99 1e-19
UniRef50_Q5D184 Cluster: Ephrin receptor; n=2; Apocrita|Rep: Eph... 99 1e-19
UniRef50_A7RNB2 Cluster: Predicted protein; n=1; Nematostella ve... 99 1e-19
UniRef50_Q96HF4 Cluster: EPHA2 protein; n=3; Amniota|Rep: EPHA2 ... 99 1e-19
UniRef50_P42687 Cluster: Tyrosine-protein kinase SPK-1; n=1; Gir... 99 1e-19
UniRef50_P43405 Cluster: Tyrosine-protein kinase SYK; n=23; Ther... 99 1e-19
UniRef50_UPI0000E470E3 Cluster: PREDICTED: similar to Fer, parti... 98 2e-19
UniRef50_UPI0000DB7A0A Cluster: PREDICTED: similar to FMS-like t... 98 2e-19
UniRef50_UPI0000D8BE91 Cluster: UPI0000D8BE91 related cluster; n... 98 2e-19
UniRef50_Q4JDD5 Cluster: Tyrosine-protein kinase receptor; n=5; ... 98 2e-19
UniRef50_Q7Q0U2 Cluster: ENSANGP00000012311; n=1; Anopheles gamb... 98 2e-19
UniRef50_Q4H3N2 Cluster: Epidermal growth factor receptor; n=1; ... 98 2e-19
UniRef50_Q15375 Cluster: Ephrin type-A receptor 7 precursor; n=5... 98 2e-19
UniRef50_Q9UF33 Cluster: Ephrin type-A receptor 6 precursor; n=5... 98 2e-19
UniRef50_UPI0000DB7A04 Cluster: PREDICTED: similar to lemur tyro... 98 2e-19
UniRef50_UPI000065F647 Cluster: Ephrin type-B receptor 2 precurs... 98 2e-19
UniRef50_Q4RP85 Cluster: Tyrosine-protein kinase receptor; n=3; ... 98 2e-19
UniRef50_Q4H3N3 Cluster: Epidermal growth factor receptor; n=1; ... 97 3e-19
UniRef50_Q26566 Cluster: Epidermal growth factor receptor precur... 97 3e-19
UniRef50_Q8AXB3 Cluster: Vascular endothelial growth factor rece... 97 3e-19
UniRef50_Q14289 Cluster: Protein tyrosine kinase 2 beta; n=47; E... 97 3e-19
UniRef50_P29323 Cluster: Ephrin type-B receptor 2 precursor; n=3... 97 3e-19
UniRef50_UPI0000F1F8B4 Cluster: PREDICTED: hypothetical protein;... 97 4e-19
UniRef50_Q9N3S5 Cluster: Putative uncharacterized protein; n=4; ... 97 4e-19
UniRef50_Q25199 Cluster: Tyrosine kinase receptor; n=7; Hydra|Re... 97 4e-19
UniRef50_UPI0000DB7330 Cluster: PREDICTED: similar to Ack CG1499... 97 5e-19
UniRef50_UPI00004CFD13 Cluster: Serine/threonine-protein kinase ... 97 5e-19
UniRef50_Q7PT15 Cluster: ENSANGP00000009263; n=2; Culicidae|Rep:... 97 5e-19
UniRef50_Q5GIT4 Cluster: Vascular endothelial growth factor rece... 97 5e-19
UniRef50_Q06187 Cluster: Tyrosine-protein kinase BTK; n=54; Gnat... 97 5e-19
UniRef50_UPI00015B4221 Cluster: PREDICTED: similar to tyrosine-p... 96 7e-19
UniRef50_Q61BE3 Cluster: Putative uncharacterized protein CBG133... 96 7e-19
UniRef50_UPI0001556099 Cluster: PREDICTED: similar to PTK7 prote... 96 9e-19
UniRef50_UPI0000F1F4DA Cluster: PREDICTED: hypothetical protein;... 96 9e-19
UniRef50_UPI0000D563AD Cluster: PREDICTED: similar to CG3969-PA,... 96 9e-19
UniRef50_UPI00015A61DF Cluster: UPI00015A61DF related cluster; n... 96 9e-19
UniRef50_UPI000065E468 Cluster: Homolog of Gallus gallus "Ephrin... 96 9e-19
UniRef50_Q4RHE1 Cluster: Chromosome 3 SCAF15050, whole genome sh... 96 9e-19
UniRef50_A0JMM7 Cluster: Zgc:154019; n=2; Danio rerio|Rep: Zgc:1... 96 9e-19
UniRef50_Q6SAX5 Cluster: Epidermal growth factor receptor; n=14;... 96 9e-19
UniRef50_Q5MCM8 Cluster: Protein-tyrosine kinase; n=2; Anthomedu... 96 9e-19
UniRef50_A7RL50 Cluster: Predicted protein; n=1; Nematostella ve... 96 9e-19
UniRef50_P29322 Cluster: Ephrin type-A receptor 8 precursor; n=2... 96 9e-19
UniRef50_UPI0000DB7B4C Cluster: PREDICTED: similar to hopscotch ... 95 1e-18
UniRef50_Q4RY69 Cluster: Chromosome 3 SCAF14978, whole genome sh... 95 1e-18
UniRef50_Q0MQ66 Cluster: Putative uncharacterized protein; n=5; ... 95 1e-18
UniRef50_O17391 Cluster: Protein kinase protein 9, isoform b; n=... 95 1e-18
UniRef50_UPI000065FEDC Cluster: Activated CDC42 kinase 1 (EC 2.7... 95 2e-18
UniRef50_UPI000065E56D Cluster: EPHB1_HUMAN Isoform 3 of P54762 ... 95 2e-18
UniRef50_Q4SMB8 Cluster: Chromosome 3 SCAF14553, whole genome sh... 95 2e-18
UniRef50_O02742 Cluster: Activated CDC42 kinase 2; n=13; Euteleo... 95 2e-18
UniRef50_UPI00015B6067 Cluster: PREDICTED: similar to tyrosine p... 95 2e-18
UniRef50_UPI00015B5C00 Cluster: PREDICTED: similar to VEGFR-A sp... 95 2e-18
UniRef50_Q4SMF1 Cluster: Chromosome 8 SCAF14552, whole genome sh... 95 2e-18
UniRef50_Q4H3M4 Cluster: Ephrin receptor; n=2; Ciona intestinali... 95 2e-18
UniRef50_Q23554 Cluster: Putative uncharacterized protein; n=1; ... 95 2e-18
UniRef50_UPI00015B5A01 Cluster: PREDICTED: similar to protein ki... 94 3e-18
UniRef50_UPI00015B4B9F Cluster: PREDICTED: similar to prenylcyst... 94 3e-18
UniRef50_UPI0000DB7238 Cluster: PREDICTED: similar to Discoidin ... 94 3e-18
UniRef50_UPI0000D56AE3 Cluster: PREDICTED: similar to CG1594-PA;... 94 3e-18
UniRef50_Q9U8U9 Cluster: PDGFR-like; n=1; Eptatretus burgeri|Rep... 94 3e-18
UniRef50_Q9PWD1 Cluster: Tyrosine-protein kinase; n=3; Tetraodon... 94 3e-18
UniRef50_Q4S1M5 Cluster: Chromosome 6 SCAF14768, whole genome sh... 94 3e-18
UniRef50_Q9Y1Y0 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 94 3e-18
UniRef50_Q8IQ00 Cluster: CG3277-PB, isoform B; n=3; Sophophora|R... 94 3e-18
UniRef50_Q25198 Cluster: Receptor tyrosine kinase 90; n=1; Hydra... 94 3e-18
UniRef50_P42159 Cluster: Class II receptor tyrosine kinase; n=5;... 94 3e-18
UniRef50_Q07912 Cluster: Activated CDC42 kinase 1; n=24; Euteleo... 94 3e-18
UniRef50_UPI00015B5DE3 Cluster: PREDICTED: hypothetical protein;... 94 4e-18
UniRef50_UPI0000E48069 Cluster: PREDICTED: hypothetical protein;... 94 4e-18
UniRef50_UPI0000DB6C79 Cluster: PREDICTED: similar to PTK7 prote... 94 4e-18
UniRef50_Q86MD7 Cluster: EGF receptor; n=1; Echinococcus multilo... 94 4e-18
UniRef50_Q4H3M3 Cluster: Ephrin receptor like protein; n=1; Cion... 94 4e-18
UniRef50_P42680 Cluster: Tyrosine-protein kinase Tec; n=86; Coel... 94 4e-18
UniRef50_UPI00015B4A8D Cluster: PREDICTED: similar to receptor t... 93 5e-18
UniRef50_UPI00006A0D3B Cluster: Tyrosine protein-kinase STYK1 (E... 93 5e-18
UniRef50_Q60I21 Cluster: TEC family protein tyrosine kinase; n=1... 93 5e-18
UniRef50_P41240 Cluster: Tyrosine-protein kinase CSK; n=21; Deut... 93 5e-18
UniRef50_UPI0000660568 Cluster: Ephrin type-B receptor 2 precurs... 93 7e-18
UniRef50_O77132 Cluster: Non-receptor protein-tyrosine kinase CS... 93 7e-18
UniRef50_A1IKE0 Cluster: Receptor tyrosine kinase-like orphan re... 93 7e-18
UniRef50_Q4RXV8 Cluster: Chromosome 11 SCAF14979, whole genome s... 93 9e-18
UniRef50_Q9VZI2 Cluster: CG14992-PA; n=3; Sophophora|Rep: CG1499... 93 9e-18
UniRef50_O17408 Cluster: Putative uncharacterized protein; n=1; ... 93 9e-18
UniRef50_A7S934 Cluster: Predicted protein; n=4; Nematostella ve... 93 9e-18
UniRef50_A3EXK6 Cluster: Fibroblast growth factor receptor c; n=... 93 9e-18
UniRef50_UPI0000E47C0F Cluster: PREDICTED: similar to focal adhe... 92 1e-17
UniRef50_UPI00006A26D5 Cluster: UPI00006A26D5 related cluster; n... 92 2e-17
UniRef50_Q9Y1Y4 Cluster: Tyrosine-protein kinase; n=1; Ephydatia... 92 2e-17
UniRef50_Q60WJ5 Cluster: Putative uncharacterized protein CBG191... 92 2e-17
UniRef50_O17755 Cluster: Putative uncharacterized protein; n=3; ... 92 2e-17
UniRef50_UPI0000ECD739 Cluster: Cytoplasmic tyrosine-protein kin... 91 2e-17
UniRef50_Q4TFI7 Cluster: Chromosome undetermined SCAF4439, whole... 91 2e-17
UniRef50_Q27HR1 Cluster: Ret tyrosine-kinase receptor; n=1; Bran... 91 2e-17
UniRef50_UPI00015B629F Cluster: PREDICTED: similar to CG33531-PA... 91 3e-17
UniRef50_Q4RU24 Cluster: Chromosome 12 SCAF14996, whole genome s... 91 3e-17
UniRef50_O76411 Cluster: Suppressor of constitutive dauer format... 91 3e-17
UniRef50_Q08881 Cluster: Tyrosine-protein kinase ITK/TSK; n=18; ... 91 3e-17
UniRef50_Q4SFK0 Cluster: Chromosome 7 SCAF14601, whole genome sh... 91 4e-17
UniRef50_Q16UV1 Cluster: Protein kinase protein; n=3; Culicidae|... 91 4e-17
UniRef50_A7RX97 Cluster: Predicted protein; n=1; Nematostella ve... 91 4e-17
UniRef50_Q16LR4 Cluster: Tyrosine protein kinase; n=5; Coelomata... 90 5e-17
UniRef50_UPI0000E49AD1 Cluster: PREDICTED: similar to mixed line... 90 6e-17
UniRef50_UPI0000499A85 Cluster: protein kinase; n=1; Entamoeba h... 90 6e-17
UniRef50_Q4SN85 Cluster: Chromosome 8 SCAF14543, whole genome sh... 90 6e-17
UniRef50_Q1LUT7 Cluster: Novel protein similar to vertebrate ser... 90 6e-17
UniRef50_Q70W05 Cluster: Src protein; n=1; Ciona intestinalis|Re... 90 6e-17
UniRef50_Q21038 Cluster: Putative uncharacterized protein ver-3;... 90 6e-17
UniRef50_Q0IFX6 Cluster: Pdgf/vegf receptor; n=1; Aedes aegypti|... 90 6e-17
UniRef50_P34892 Cluster: Receptor-like tyrosine-protein kinase k... 90 6e-17
UniRef50_Q20933 Cluster: Putative uncharacterized protein; n=1; ... 89 8e-17
UniRef50_UPI000065E2FA Cluster: Homolog of Homo sapiens "Tyrosin... 89 1e-16
UniRef50_Q4T1R9 Cluster: Chromosome 4 SCAF10492, whole genome sh... 89 1e-16
UniRef50_UPI0000DB7571 Cluster: PREDICTED: similar to mitogen-ac... 89 1e-16
UniRef50_UPI0000DB72A0 Cluster: PREDICTED: similar to R151.4a; n... 89 1e-16
UniRef50_UPI00015B629D Cluster: PREDICTED: similar to CG33531-PA... 88 2e-16
UniRef50_Q6W5B1 Cluster: TEL/JAK2 fusion protein; n=4; Danio rer... 88 2e-16
UniRef50_O45232 Cluster: Putative uncharacterized protein ark-1;... 88 2e-16
UniRef50_Q9M085 Cluster: Protein kinase-like protein; n=22; Magn... 88 2e-16
UniRef50_Q0PDJ5 Cluster: Protein tyrosine kinase CSK; n=1; Monos... 88 2e-16
UniRef50_Q4SF69 Cluster: Chromosome undetermined SCAF14608, whol... 87 3e-16
UniRef50_Q39886 Cluster: Protein kinase; n=7; Magnoliophyta|Rep:... 87 3e-16
UniRef50_O02064 Cluster: Putative uncharacterized protein; n=1; ... 87 3e-16
UniRef50_Q9XYS4 Cluster: Tyrosine kinase receptor HTK32; n=1; Hy... 87 4e-16
UniRef50_P29597 Cluster: Non-receptor tyrosine-protein kinase TY... 87 4e-16
UniRef50_UPI00015B46B5 Cluster: PREDICTED: similar to CG33531-PA... 87 6e-16
UniRef50_UPI00004D86FC Cluster: Tyrosine-protein kinase Tec (EC ... 87 6e-16
UniRef50_Q17HL3 Cluster: Discoidin domain receptor; n=3; Culicid... 87 6e-16
UniRef50_O61460 Cluster: Ephrin receptor 1 precursor; n=3; Caeno... 87 6e-16
UniRef50_UPI000065F9C5 Cluster: Epithelial discoidin domain-cont... 86 8e-16
UniRef50_Q4SUM3 Cluster: Ephrin receptor; n=4; Tetraodon nigrovi... 86 8e-16
UniRef50_Q4S883 Cluster: Chromosome 3 SCAF14707, whole genome sh... 86 8e-16
UniRef50_O01798 Cluster: Defective spermatogenesis protein 8; n=... 86 8e-16
UniRef50_UPI0000D55944 Cluster: PREDICTED: similar to CG8967-PA;... 86 1e-15
UniRef50_UPI0000519EF1 Cluster: PREDICTED: similar to CG31640-PA... 86 1e-15
UniRef50_Q10925-2 Cluster: Isoform b of Q10925 ; n=2; Caenorhabd... 86 1e-15
UniRef50_Q10925 Cluster: Probable tyrosine-protein kinase kin-25... 86 1e-15
UniRef50_Q4SI07 Cluster: Ephrin receptor; n=8; Clupeocephala|Rep... 85 1e-15
UniRef50_A4RXI8 Cluster: Predicted protein; n=2; Ostreococcus|Re... 85 1e-15
UniRef50_Q55GU0 Cluster: Protein kinase, TKL group; n=1; Dictyos... 85 1e-15
UniRef50_Q4H377 Cluster: Mitogen-activated protein kinase kinase... 85 1e-15
UniRef50_O60674 Cluster: Tyrosine-protein kinase JAK2; n=48; Eut... 85 1e-15
UniRef50_UPI00015B54DC Cluster: PREDICTED: similar to vascular e... 85 2e-15
UniRef50_UPI0000F1DBB6 Cluster: PREDICTED: hypothetical protein;... 85 2e-15
UniRef50_UPI00006A1DD3 Cluster: UPI00006A1DD3 related cluster; n... 85 2e-15
UniRef50_P79884 Cluster: Insulin-like growth factor-I receptor; ... 85 2e-15
UniRef50_Q54U31 Cluster: SH2 domain-containing protein; n=1; Dic... 85 2e-15
UniRef50_P34891 Cluster: Receptor-like tyrosine-protein kinase k... 85 2e-15
UniRef50_O12990 Cluster: Tyrosine-protein kinase Jak1; n=8; Eute... 85 2e-15
UniRef50_Q9FIL6 Cluster: Protein-tyrosine kinase; n=10; core eud... 84 3e-15
UniRef50_Q8I7I5 Cluster: Roller: helically twisted, animals roll... 84 3e-15
UniRef50_A7SIN7 Cluster: Predicted protein; n=4; Eumetazoa|Rep: ... 84 3e-15
UniRef50_Q9Y1Z4 Cluster: Protein tyrosine kinase 37; n=1; Hydra ... 84 4e-15
UniRef50_Q4H3A3 Cluster: Janus kinase; n=1; Ciona intestinalis|R... 84 4e-15
UniRef50_Q6J9G0 Cluster: Tyrosine protein-kinase STYK1; n=20; Am... 84 4e-15
UniRef50_A2FI59 Cluster: TKL family protein kinase; n=1; Trichom... 83 5e-15
UniRef50_Q24592 Cluster: Tyrosine-protein kinase hopscotch; n=2;... 83 7e-15
UniRef50_UPI0000F1F986 Cluster: PREDICTED: similar to mixed line... 83 9e-15
UniRef50_UPI0000E49426 Cluster: PREDICTED: hypothetical protein;... 83 9e-15
UniRef50_Q24327 Cluster: Gp160-Dtrk precursor; n=4; Sophophora|R... 83 9e-15
UniRef50_A2EIX4 Cluster: TKL family protein kinase; n=1; Trichom... 83 9e-15
UniRef50_P52333 Cluster: Tyrosine-protein kinase JAK3; n=17; Eut... 83 9e-15
UniRef50_A2EHA2 Cluster: TKL family protein kinase; n=1; Trichom... 82 1e-14
UniRef50_A2DZZ0 Cluster: TKL family protein kinase; n=1; Trichom... 82 1e-14
UniRef50_Q5JZY3 Cluster: Ephrin type-A receptor 10 precursor; n=... 82 1e-14
>UniRef50_UPI0000DB74F2 Cluster: PREDICTED: similar to Derailed 2
CG3915-PB, isoform B; n=1; Apis mellifera|Rep:
PREDICTED: similar to Derailed 2 CG3915-PB, isoform B -
Apis mellifera
Length = 498
Score = 248 bits (607), Expect = 1e-64
Identities = 124/264 (46%), Positives = 163/264 (61%), Gaps = 6/264 (2%)
Query: 3 ASGQTVTKDRVTDPAEQLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKT 62
AS + TDP E+ R L SRS + L+ EGTFGR+YKG + +EV++KT
Sbjct: 203 ASSHVTHLSQSTDPCEKARALAVSRSALYCRNLVQEGTFGRVYKGTLELAGREQEVIIKT 262
Query: 63 XXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLS 122
EG +L GLVH+N+ + AAC + + PLL Y NLK +L+
Sbjct: 263 VTEVASAYQASLLVVEGSQLAGLVHSNIASLAAACLDSSC-PLLAYTSTPGELNLKLYLT 321
Query: 123 SCRLGQQSAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVD-EKLRLKVTDNGL 181
G P TR+LV +GAQVA ++LH + +H D+AARNC+++ LR+++ D L
Sbjct: 322 D---GNHH-PGTRDLVHVGAQVARAGAFLHGRGLLHRDIAARNCLIEPSSLRVRLADTAL 377
Query: 182 ARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAEL 241
ARDLFP DYHCLGDNENRP++WMA ETL NQYSTA+DVWS G+ LWELAT+G P E+
Sbjct: 378 ARDLFPQDYHCLGDNENRPIRWMALETLQHNQYSTATDVWSFGVFLWELATMGQQPYVEV 437
Query: 242 DAADVGAFLNGGYRPSQPHNCPDE 265
D ++ A L GYR +QP CPDE
Sbjct: 438 DPFEMMACLRDGYRLAQPRPCPDE 461
>UniRef50_Q4RH14 Cluster: Chromosome undetermined SCAF15074, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF15074,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 654
Score = 242 bits (592), Expect = 7e-63
Identities = 114/254 (44%), Positives = 164/254 (64%), Gaps = 7/254 (2%)
Query: 19 QLRVLTTSRSNIRLEILIHEGTFGRIYKGVF---KKGDVYEEVMVKTXXXXXXXXXXXXX 75
+++ L+ SR + L ++ EGTFG+I+ GV K ++V VKT
Sbjct: 366 RVKDLSVSRDRVTLGDVLQEGTFGQIFHGVLLDEKDPSKEKQVFVKTVKDHASEVQVTMM 425
Query: 76 XXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPAT- 134
E L+L GL H N+L C E+ KP+++ + NLK FL C+L + + P +
Sbjct: 426 LTESLKLRGLHHRNLLPISHVCTEDGEKPMVLLPFVAWG-NLKLFLRQCKLAEANNPQSV 484
Query: 135 --RELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHC 192
++LV + Q+ACG+SYL + +H D+AARNCV+D+ +++K++DN LARDLFP DYHC
Sbjct: 485 SQQDLVSMAIQIACGMSYLSRREVIHKDLAARNCVIDDSMQVKISDNALARDLFPMDYHC 544
Query: 193 LGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNG 252
LGDNENRPV+WMA E+LL N +S+ SDVW+ G+TLWEL TLG +P ++D ++ A+L
Sbjct: 545 LGDNENRPVRWMALESLLHNDFSSLSDVWAFGVTLWELMTLGQTPYVDIDPFEMSAYLKD 604
Query: 253 GYRPSQPHNCPDEL 266
GYR +QP NCPDEL
Sbjct: 605 GYRIAQPINCPDEL 618
>UniRef50_P34925 Cluster: Tyrosine-protein kinase RYK precursor;
n=37; Euteleostomi|Rep: Tyrosine-protein kinase RYK
precursor - Homo sapiens (Human)
Length = 604
Score = 242 bits (592), Expect = 7e-63
Identities = 115/254 (45%), Positives = 165/254 (64%), Gaps = 7/254 (2%)
Query: 19 QLRVLTTSRSNIRLEILIHEGTFGRIYKGVF---KKGDVYEEVMVKTXXXXXXXXXXXXX 75
+++ + SR I L+ ++ EGTFGRI+ G+ K + ++ VKT
Sbjct: 316 KVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMM 375
Query: 76 XXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAP--- 132
E +L GL H N+L C EE KP++I + NLK FL C+L + + P
Sbjct: 376 LTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWG-NLKLFLRQCKLVEANNPQAI 434
Query: 133 ATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHC 192
+ ++LV + Q+ACG+SYL + +H D+AARNCV+D+ L++K+TDN L+RDLFP DYHC
Sbjct: 435 SQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHC 494
Query: 193 LGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNG 252
LGDNENRPV+WMA E+L+ N++S+ASDVW+ G+TLWEL TLG +P ++D ++ A+L
Sbjct: 495 LGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKD 554
Query: 253 GYRPSQPHNCPDEL 266
GYR +QP NCPDEL
Sbjct: 555 GYRIAQPINCPDEL 568
>UniRef50_UPI00015B55E2 Cluster: PREDICTED: similar to
tyrosine-protein kinase drl; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to tyrosine-protein
kinase drl - Nasonia vitripennis
Length = 559
Score = 239 bits (586), Expect = 4e-62
Identities = 119/254 (46%), Positives = 152/254 (59%), Gaps = 6/254 (2%)
Query: 14 TDPAEQLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXX 73
TDP E+ R + RS + +I EGTFGR+Y+G + +EV++KT
Sbjct: 275 TDPCEKARAVAVPRSALHCRSVIQEGTFGRVYRGGLSQAGREQEVIIKTVTDVASAYQAS 334
Query: 74 XXXXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPA 133
EG +L GLVH N+ T AAC E P+L Y C NLK +L+ G P
Sbjct: 335 LLVVEGSQLAGLVHGNIATLAAACLE-GTCPMLAYACSPSDLNLKTYLTD---GSHH-PV 389
Query: 134 TRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEK-LRLKVTDNGLARDLFPDDYHC 192
TR+LV++ QVA ++LH + +H D+A RNC+VD LR ++ D L+RDLFP DYHC
Sbjct: 390 TRDLVNIAVQVARAGAFLHGRGILHRDIATRNCLVDTSTLRTRLADAALSRDLFPQDYHC 449
Query: 193 LGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNG 252
LGDNENR + WMA ETL QYSTASD WS G+ LWELAT+G P E+D ++ FL
Sbjct: 450 LGDNENRAIGWMALETLQHGQYSTASDAWSFGVFLWELATMGQQPYLEVDPFELTVFLRD 509
Query: 253 GYRPSQPHNCPDEL 266
GYR SQP CPDEL
Sbjct: 510 GYRLSQPRPCPDEL 523
>UniRef50_Q16VL6 Cluster: Tyrosine-protein kinase; n=1; Aedes
aegypti|Rep: Tyrosine-protein kinase - Aedes aegypti
(Yellowfever mosquito)
Length = 379
Score = 233 bits (570), Expect = 3e-60
Identities = 117/258 (45%), Positives = 164/258 (63%), Gaps = 8/258 (3%)
Query: 14 TDPAEQLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKK--GDVYEEVMVKTXXXXXXXXX 71
+ P ++LR + S I + L EGT+GRI+ GV G+ +V++KT
Sbjct: 87 SSPKDKLRRIAVSPDTIICQQLAQEGTYGRIFYGVLHHPLGET-RDVLIKTVVDGASLSQ 145
Query: 72 XXXXXXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCR-LGQQS 130
EG L G+ H N+L P+AA E + P + Y + NLK +L SCR +G QS
Sbjct: 146 VAYLLSEGSTLCGVSHPNILFPVAAVTELSGPPKVAYPLAA-KGNLKLYLQSCRDIGIQS 204
Query: 131 AP---ATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFP 187
+ +TR+LV+ G QVA G+S+LH +H D+A RNCV+D + ++V DN L+RD+FP
Sbjct: 205 SGISLSTRQLVEFGLQVARGISHLHSLGVLHKDIATRNCVLDSEQNVRVCDNALSRDVFP 264
Query: 188 DDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVG 247
+DYHCLGDNENRP+KWMA ETL + Y+ +SD+WSLG+ LWELATL + P E+D+ ++
Sbjct: 265 NDYHCLGDNENRPIKWMALETLEKKFYTASSDIWSLGVLLWELATLAAMPFEEVDSFELA 324
Query: 248 AFLNGGYRPSQPHNCPDE 265
A+L GYR +QP NCPDE
Sbjct: 325 AYLRDGYRLAQPVNCPDE 342
>UniRef50_UPI0000E48358 Cluster: PREDICTED: hypothetical protein;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
hypothetical protein - Strongylocentrotus purpuratus
Length = 522
Score = 230 bits (562), Expect = 3e-59
Identities = 116/245 (47%), Positives = 150/245 (61%), Gaps = 8/245 (3%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVF--KKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYG 84
RS I L ++ EGTFGR+++GV GD ++V +KT E L G
Sbjct: 245 RSRITLGEVLLEGTFGRVHQGVLISATGDSEQDVFIKTVTDHSSEEQRHLLVKESCLLQG 304
Query: 85 LVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLG---QQSAPATRELVDLG 141
L H N+L + C + P I NLK+FL + R+G + A +TR+LV L
Sbjct: 305 LSHKNILPLLHVCFSD---PPFILEAFMKLGNLKQFLKNGRIGPGDKHQAISTRDLVHLA 361
Query: 142 AQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPV 201
Q+ G+ YL +R VH D+A RNCV+DE LK+TDN L+RDLFP DYHCLGDNENRPV
Sbjct: 362 IQITHGMMYLGKKRLVHKDLATRNCVIDEDYNLKITDNALSRDLFPSDYHCLGDNENRPV 421
Query: 202 KWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHN 261
KWMA E+L+ ++S ASDVWS G+TLWEL TLG +P +LD ++ FL GYR QP +
Sbjct: 422 KWMAVESLVHKKFSHASDVWSFGVTLWELVTLGQTPYMDLDPFEMATFLKSGYRMPQPPS 481
Query: 262 CPDEL 266
CPDEL
Sbjct: 482 CPDEL 486
>UniRef50_Q17PG3 Cluster: Tyrosine-protein kinase drl; n=5;
Endopterygota|Rep: Tyrosine-protein kinase drl - Aedes
aegypti (Yellowfever mosquito)
Length = 535
Score = 225 bits (551), Expect = 7e-58
Identities = 106/244 (43%), Positives = 146/244 (59%), Gaps = 6/244 (2%)
Query: 23 LTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRL 82
LT R +RL L+ EGTFGR+Y+G + +EV+VKT EG+ L
Sbjct: 262 LTVQRCRVRLSSLLQEGTFGRVYRGSYNDS---QEVLVKTVGQHASQIQVSLLLQEGMSL 318
Query: 83 YGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGA 142
YG H +L+ + E+ P L+Y P + NLK FL T ++V +
Sbjct: 319 YGAQHPGILSVLGVSIEDHTAPFLLYLAPDNMRNLKIFLQE---PVARTMTTIQIVKIQL 375
Query: 143 QVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVK 202
Q+A L +LH +H D+AARNCV+D++LR+K+ DN L+RDLFP DY+CLGD+ENRP+K
Sbjct: 376 QLAQALGHLHSHGVIHKDIAARNCVIDDQLRVKLADNSLSRDLFPGDYYCLGDSENRPIK 435
Query: 203 WMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNC 262
W+A E + Q+S ASD W+ G+ +WEL TL P AE+D ++ +L GYR SQP NC
Sbjct: 436 WLALEAIQYKQFSEASDTWAFGVLMWELCTLARQPYAEVDPFEMEHYLRDGYRLSQPINC 495
Query: 263 PDEL 266
PDEL
Sbjct: 496 PDEL 499
>UniRef50_Q9V422 Cluster: Tyrosine-protein kinase Dnt precursor;
n=3; Sophophora|Rep: Tyrosine-protein kinase Dnt
precursor - Drosophila melanogaster (Fruit fly)
Length = 584
Score = 217 bits (531), Expect = 2e-55
Identities = 101/244 (41%), Positives = 149/244 (61%), Gaps = 5/244 (2%)
Query: 23 LTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRL 82
LT R +RL L+ EGTFGR+Y+G + ++V+VKT EG+ L
Sbjct: 310 LTVERCRVRLSSLLQEGTFGRVYRGTYNDT---QDVLVKTVAQHASQMQVLLLLQEGMLL 366
Query: 83 YGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGA 142
YG H +L+ + E+ P ++Y +++ NLK+FL + T ++V + +
Sbjct: 367 YGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQFLLDPACAR--TVTTIQIVMMAS 424
Query: 143 QVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVK 202
Q++ L +LH VH D+A RNCV+D++LR+K++D+ L+RDLFP DY+CLGD+ENRPVK
Sbjct: 425 QLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVK 484
Query: 203 WMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNC 262
WM+ E L Q+S ASD W+ G+ +WEL T P AE+D ++ +L GYR +QP NC
Sbjct: 485 WMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNC 544
Query: 263 PDEL 266
PDEL
Sbjct: 545 PDEL 548
>UniRef50_Q27324 Cluster: Tyrosine-protein kinase Drl precursor;
n=2; Sophophora|Rep: Tyrosine-protein kinase Drl
precursor - Drosophila melanogaster (Fruit fly)
Length = 610
Score = 214 bits (523), Expect = 2e-54
Identities = 101/248 (40%), Positives = 148/248 (59%), Gaps = 5/248 (2%)
Query: 19 QLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXE 78
+L+ LT + +RL L+ EG FGRIY+G + +EV+VKT E
Sbjct: 332 RLQELTVQKCRVRLSCLVQEGNFGRIYRGTYND---CQEVLVKTVAQHASQLQVNLLLQE 388
Query: 79 GLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELV 138
+ LY H NVL+ + E+ P ++Y NLK FL + + T + V
Sbjct: 389 SMMLYEASHPNVLSVLGISIEDYATPFVLYAATGSVRNLKSFLQDPSYAR--SVTTIQTV 446
Query: 139 DLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNEN 198
+G+Q+A + +LH +H D+AARNCV+D++LR+K+TD+ L+RDLFP DY+ LGD E
Sbjct: 447 LMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDGEY 506
Query: 199 RPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQ 258
RP+KW++ E L ++ Y+ SDVWS G+ +WE+ TLG P AE+D ++ +L GYR +Q
Sbjct: 507 RPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQ 566
Query: 259 PHNCPDEL 266
P NCPDEL
Sbjct: 567 PFNCPDEL 574
>UniRef50_Q7JQT0 Cluster: GH27039p; n=4; Diptera|Rep: GH27039p -
Drosophila melanogaster (Fruit fly)
Length = 648
Score = 205 bits (500), Expect = 1e-51
Identities = 110/264 (41%), Positives = 153/264 (57%), Gaps = 7/264 (2%)
Query: 4 SGQTVTKDRVTDPAEQ-LRVLTTSRSN-IRLEILIHEGTFGRIYKGVFKKGDVYEEVMVK 61
+G T+T + Q LR +T+ + + E L+ EGTFGRIY G K G+ E +VK
Sbjct: 353 TGSTITMASHGEKGNQRLRRITSVQPGALSYEELVKEGTFGRIYAG--KLGESCE-ALVK 409
Query: 62 TXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFL 121
T + L G+ H ++L P+ A E P + Y PS NLK +L
Sbjct: 410 TVIDGASLTQVACLLQDASLLIGVSHQHILAPLLANTELPGPPEIAYPHPS-KGNLKMYL 468
Query: 122 SSCRLGQQSAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGL 181
R +A +TR+LV+ G + GL+YLH VH D+A RNC +DE+ +K+ D+ L
Sbjct: 469 QKSR-ESSTALSTRQLVEFGLHITKGLAYLHSLGIVHKDIATRNCYLDEESYVKICDSAL 527
Query: 182 ARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAEL 241
+RDLFPDDY CLGDNENRP+KW++ E+L + Y+T DVW+LG+T WEL TL P E+
Sbjct: 528 SRDLFPDDYDCLGDNENRPLKWLSLESLQKRVYATQGDVWALGVTYWELVTLAQMPHEEV 587
Query: 242 DAADVGAFLNGGYRPSQPHNCPDE 265
D ++ +L G+R QP NCPDE
Sbjct: 588 DIFELTNYLAAGFRLEQPVNCPDE 611
>UniRef50_UPI00015B55E4 Cluster: PREDICTED: similar to receptor-like
tyrosine kinase; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to receptor-like tyrosine kinase -
Nasonia vitripennis
Length = 503
Score = 185 bits (450), Expect = 1e-45
Identities = 77/131 (58%), Positives = 102/131 (77%)
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGD 195
++V++ Q A G+ YLH +R VH D+AARNCVVD++LR+++TDN LARDLFP DY+CLGD
Sbjct: 337 QVVEMALQAAKGVQYLHRKRLVHRDLAARNCVVDDELRVQITDNALARDLFPQDYYCLGD 396
Query: 196 NENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYR 255
NENRP+KW+A E+LL +STASDVW+ G+ LWEL TL P E+D ++ ++L GYR
Sbjct: 397 NENRPIKWLAIESLLSKSFSTASDVWAFGVLLWELTTLAQQPYVEVDPFEMASYLRDGYR 456
Query: 256 PSQPHNCPDEL 266
+QP NCPDEL
Sbjct: 457 LAQPVNCPDEL 467
Score = 35.9 bits (79), Expect = 1.1
Identities = 17/47 (36%), Positives = 30/47 (63%), Gaps = 2/47 (4%)
Query: 18 EQLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKK--GDVYEEVMVKT 62
E+++ +T R +RL + EGTFGR+Y+G + + ++V+VKT
Sbjct: 282 ERIQEITVQRCRVRLLSVEMEGTFGRVYRGSYHEEGATTPKDVLVKT 328
>UniRef50_Q9XZ66 Cluster: Tyrosine kinase receptor-related protein
precursor RYK; n=3; Caenorhabditis|Rep: Tyrosine kinase
receptor-related protein precursor RYK - Caenorhabditis
elegans
Length = 583
Score = 182 bits (444), Expect = 6e-45
Identities = 112/297 (37%), Positives = 161/297 (54%), Gaps = 32/297 (10%)
Query: 2 NASGQTV--TKDRVTDPAEQLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKK------GD 53
+ASG ++ +K R D L L R + L EGTFG + ++++ GD
Sbjct: 251 SASGNSIIPSKPRNIDVRRALLQLYQDRDAFQSLPLDMEGTFGEVRYAIWRQVDDVLNGD 310
Query: 54 VYEE---------VMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMAACAEEAR-- 102
V +E V KT + L Y + L+ +A A R
Sbjct: 311 VDDEEDTFCNQEAVYTKTLKNNASPIQLDRFLSDALLFYNITPHQNLSQVACVASFGRFD 370
Query: 103 KPLLI----YCCPSHSS--NLKRFLSSCRLGQQSAPA----TRELVDLGAQVACGLSYLH 152
+P + C H NLK+FL+ CR G ++ A T +LV L QV+ ++++H
Sbjct: 371 RPETVTDFPLVCYRHQGFGNLKKFLTICRHGDKTKGAQTLRTHQLVSLATQVSSAVAHIH 430
Query: 153 VQRFVHADVAARNCVVDE---KLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPETL 209
R VH D+AARNC++ E +L++++ D+ L+RDLFP DYHCLGDNENRP+KWM+PE +
Sbjct: 431 KYRIVHNDIAARNCLIAEVNGRLQVQLCDSALSRDLFPADYHCLGDNENRPLKWMSPEAI 490
Query: 210 LQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
YS+A+DVWSLG+ LWEL +LG SP AE+D +V + G R QP+NCPD+L
Sbjct: 491 ANELYSSAADVWSLGVLLWELMSLGGSPHAEIDPEEVYTMILKGKRLQQPNNCPDQL 547
>UniRef50_P79950 Cluster: Tyrosine kinase receptor; n=3; Xenopus|Rep:
Tyrosine kinase receptor - Xenopus laevis (African clawed
frog)
Length = 1369
Score = 166 bits (403), Expect = 6e-40
Identities = 95/259 (36%), Positives = 140/259 (54%), Gaps = 13/259 (5%)
Query: 11 DRVTDPAEQLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVYE-EVMVKTXXXXXXX 69
+ V D R LTT R I I +G FG +Y G + D E VK+
Sbjct: 1043 EEVKDVLIPERCLTTHRDRI-----IGKGHFGSVYHGTYVDEDQQEVHCAVKSLNRITDL 1097
Query: 70 XXXXXXXXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQ 129
EG+ + H NVL+ + C + PL++ H +L+ F+ S ++
Sbjct: 1098 EEVEEFLREGILMKSFHHPNVLSLIGICLPQEGLPLVVLPFMKHG-DLRHFIRS----EE 1152
Query: 130 SAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDD 189
P ++LV G QV+ G+ YL ++FVH D+AARNC++DE +KV D GLARD+F +
Sbjct: 1153 RNPTVKDLVGFGLQVSRGMEYLANRKFVHRDLAARNCMLDESFHVKVADFGLARDVFDKE 1212
Query: 190 YHCLGDNENR--PVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVG 247
Y+ + ++N PVKWMA E+L +++T SDVWS G+ LWEL T G+ P ++DA D+
Sbjct: 1213 YYSVRRHKNARLPVKWMAMESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVDAYDIT 1272
Query: 248 AFLNGGYRPSQPHNCPDEL 266
+L G R +QP CP+ L
Sbjct: 1273 RYLFRGRRLAQPEYCPNPL 1291
>UniRef50_P23049 Cluster: Tyrosine-protein kinase transforming
protein SEA; n=6; root|Rep: Tyrosine-protein kinase
transforming protein SEA - Avian erythroblastosis virus
(strain S13)
Length = 370
Score = 160 bits (389), Expect = 3e-38
Identities = 87/237 (36%), Positives = 132/237 (55%), Gaps = 12/237 (5%)
Query: 35 LIHEGTFGRIYKGVFKK---GDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVL 91
+I G FG +Y G + G+++ VK+ EG+ + G H VL
Sbjct: 65 VIGRGHFGSVYHGTYMDPLLGNLH--CAVKSLHRITYLEEVEEFLREGILMKGFHHPQVL 122
Query: 92 TPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGLSYL 151
+ + C PL++ H +L+ F+ + Q+ +P +EL+ G QVA G+ YL
Sbjct: 123 SLLGVCLPRHGLPLVVLPYMRHG-DLRHFVRA----QERSPTVKELIGFGLQVALGMEYL 177
Query: 152 HVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENR--PVKWMAPETL 209
++FVH D+AARNC++DE L +KV D GLARD+F +Y+ + + + PV+WMA E+L
Sbjct: 178 AQKKFVHRDLAARNCMLDETLTVKVADFGLARDVFGKEYYSIRQHRHAKLPVRWMALESL 237
Query: 210 LQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
+++T SDVWS G+ +WEL T G+SP E+D D+ +L G R QP CPD L
Sbjct: 238 QTQKFTTKSDVWSFGVLMWELLTRGASPYPEVDPYDMARYLLRGRRLPQPQPCPDTL 294
>UniRef50_P08581 Cluster: Hepatocyte growth factor receptor precursor;
n=81; Tetrapoda|Rep: Hepatocyte growth factor receptor
precursor - Homo sapiens (Human)
Length = 1390
Score = 156 bits (378), Expect = 6e-37
Identities = 87/253 (34%), Positives = 131/253 (51%), Gaps = 8/253 (3%)
Query: 17 AEQLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVYE-EVMVKTXXXXXXXXXXXXX 75
A Q V+ S + +I G FG +Y G D + VK+
Sbjct: 1065 AVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQF 1124
Query: 76 XXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATR 135
EG+ + H NVL+ + C PL++ H +L+ F+ + + P +
Sbjct: 1125 LTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHG-DLRNFIRN----ETHNPTVK 1179
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGD 195
+L+ G QVA G+ YL ++FVH D+AARNC++DEK +KV D GLARD++ +Y+ + +
Sbjct: 1180 DLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHN 1239
Query: 196 NENR--PVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGG 253
PVKWMA E+L +++T SDVWS G+ LWEL T G+ P +++ D+ +L G
Sbjct: 1240 KTGAKLPVKWMALESLQTQKFTTKSDVWSFGVVLWELMTRGAPPYPDVNTFDITVYLLQG 1299
Query: 254 YRPSQPHNCPDEL 266
R QP CPD L
Sbjct: 1300 RRLLQPEYCPDPL 1312
>UniRef50_Q9YGM5 Cluster: Plasminogen related growth factor receptor
2; n=11; Clupeocephala|Rep: Plasminogen related growth
factor receptor 2 - Fugu rubripes (Japanese pufferfish)
(Takifugu rubripes)
Length = 1375
Score = 152 bits (369), Expect = 8e-36
Identities = 86/257 (33%), Positives = 140/257 (54%), Gaps = 10/257 (3%)
Query: 15 DPAEQLRVLTTSRSNIRLEI--LIHEGTFGRIYKGVFKKGDVYE-EVMVKTXXXXXXXXX 71
D E+++ + +R+E +I +G FG +Y G + E VK+
Sbjct: 1048 DLLEEVKNVLIPADMLRIEDRQVIGKGHFGTVYHGYLIDSNKQETHCAVKSLNRITDLKD 1107
Query: 72 XXXXXXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSA 131
EGL + G H N+L+ + + PL++ H +++ F+ S ++
Sbjct: 1108 VDHFLREGLIMKGFDHPNILSLLGIMLPKEGLPLVVLPYMKHG-DVRHFIRS----EKRN 1162
Query: 132 PATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYH 191
P ++L+ G QVA G+ YL ++FVH D+AARNC++DE +KV D G+ARD++ +Y+
Sbjct: 1163 PTVKDLIGFGLQVAKGMEYLAQKKFVHRDLAARNCMLDETYTVKVADFGMARDIYDKEYY 1222
Query: 192 CLGDNE--NRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAF 249
+ D++ PVKWMA E+L ++++ SDVWS GI +WEL T G+SP ++D D+ +
Sbjct: 1223 SIQDHKQVKLPVKWMAIESLQTQKFTSKSDVWSYGILMWELLTRGASPYPDVDPYDITNY 1282
Query: 250 LNGGYRPSQPHNCPDEL 266
L G R QP CP+ L
Sbjct: 1283 LLKGRRLPQPQFCPNTL 1299
>UniRef50_Q64GK4 Cluster: C-Met receptor tyrosine kinase; n=9;
Clupeocephala|Rep: C-Met receptor tyrosine kinase - Danio
rerio (Zebrafish) (Brachydanio rerio)
Length = 1382
Score = 152 bits (369), Expect = 8e-36
Identities = 83/246 (33%), Positives = 134/246 (54%), Gaps = 10/246 (4%)
Query: 26 SRSNIRLEI--LIHEGTFGRIYKGVFKKGDVYEE-VMVKTXXXXXXXXXXXXXXXEGLRL 82
+R ++ L + +I G FG ++ G + D ++ +K+ EG+ +
Sbjct: 1073 AREDLLLHVNEIIGRGHFGCVFHGTLLEPDGQKQHCAIKSLNRITDIEEVSQFLKEGIIV 1132
Query: 83 YGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGA 142
H NVL+ + C PL++ H +L+ F+ + P ++L+ G
Sbjct: 1133 KDFSHPNVLSLLGICLPSEGSPLVVLPYMKHG-DLRNFIRD----ESHNPTVKDLMGFGL 1187
Query: 143 QVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNEN--RP 200
QVA G+ YL ++FVH D+AARNC++DE +KV D GLARD++ +Y+ + + P
Sbjct: 1188 QVAKGMEYLASKKFVHRDLAARNCMLDESYTVKVADVGLARDVYDKEYYSVHNKHGVKLP 1247
Query: 201 VKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPH 260
VKWMA E+L ++++T SDVWS G+ LWEL T G+ P +++++ D+ FL G R QP
Sbjct: 1248 VKWMALESLQTHKFTTKSDVWSFGVLLWELMTRGAPPYSDVNSFDITVFLLQGRRLLQPE 1307
Query: 261 NCPDEL 266
CPD L
Sbjct: 1308 FCPDAL 1313
>UniRef50_Q6DTW4 Cluster: Tyrosine kinase receptor ron; n=6;
Eumetazoa|Rep: Tyrosine kinase receptor ron - Canis
familiaris (Dog)
Length = 998
Score = 151 bits (367), Expect = 1e-35
Identities = 88/235 (37%), Positives = 123/235 (52%), Gaps = 8/235 (3%)
Query: 35 LIHEGTFGRIYKGVFKKGDVYE-EVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTP 93
+I +G FG +Y G + D VK+ EGL + GL H NVL
Sbjct: 685 VIGKGHFGVVYHGEYIDEDQNRIHCAVKSLSRITEVQEAEAFLREGLLMRGLHHPNVLAL 744
Query: 94 MAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGLSYLHV 153
+ P ++ H +L RF+ S Q P ++L+ G QVA G+ YL
Sbjct: 745 IGIVLPPEGLPRVLLPYMRHG-DLLRFIRS----PQRNPTVKDLISFGLQVARGMEYLAE 799
Query: 154 QRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENR--PVKWMAPETLLQ 211
Q+FVH D+AARNC++DE +KV D GLARD+ +Y+ + + + PVKWMA E+L
Sbjct: 800 QKFVHRDLAARNCMLDESFTVKVADFGLARDILDKEYYSVRQHRHARLPVKWMALESLQT 859
Query: 212 NQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
+++T SDVWS G+ LWEL T G+ P +D D+ FL G R QP CP+ L
Sbjct: 860 YRFTTKSDVWSFGVLLWELLTRGAPPYPHIDPFDLIQFLAQGRRLPQPEYCPNSL 914
>UniRef50_Q04912 Cluster: Macrophage-stimulating protein receptor
precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CD136
antigen) (CDw136) [Contains: Macrophage- stimulating
protein receptor alpha chain; Macrophage-stimulating
protein receptor beta chain]; n=15; Eutheria|Rep:
Macrophage-stimulating protein receptor precursor (EC
2.7.10.1) (MSP receptor) (p185-Ron) (CD136 antigen)
(CDw136) [Contains: Macrophage- stimulating protein
receptor alpha chain; Macrophage-stimulating protein
receptor beta chain] - Homo sapiens (Human)
Length = 1400
Score = 151 bits (366), Expect = 2e-35
Identities = 89/237 (37%), Positives = 125/237 (52%), Gaps = 12/237 (5%)
Query: 35 LIHEGTFGRIYKGVF-KKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTP 93
+I +G FG +Y G + + + +K+ EGL + GL H NVL
Sbjct: 1087 VIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLAL 1146
Query: 94 MAACAEEARKP--LLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGLSYL 151
+ P LL Y C +L +F+ S Q P ++L+ G QVA G+ YL
Sbjct: 1147 IGIMLPPEGLPHVLLPYMC---HGDLLQFIRS----PQRNPTVKDLISFGLQVARGMEYL 1199
Query: 152 HVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENR--PVKWMAPETL 209
Q+FVH D+AARNC++DE +KV D GLARD+ +Y+ + + + PVKWMA E+L
Sbjct: 1200 AEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESL 1259
Query: 210 LQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
+++T SDVWS G+ LWEL T G+ P +D D+ FL G R QP CPD L
Sbjct: 1260 QTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSL 1316
>UniRef50_Q70W11 Cluster: Receptor tyrosine kinase X; n=1; Ciona
intestinalis|Rep: Receptor tyrosine kinase X - Ciona
intestinalis (Transparent sea squirt)
Length = 478
Score = 145 bits (351), Expect = 1e-33
Identities = 85/254 (33%), Positives = 134/254 (52%), Gaps = 14/254 (5%)
Query: 22 VLTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVYE--------EVMVKTXXXXXXXXXXX 73
+++ ++ + E +I +G FG +Y G + ++ + +V +KT
Sbjct: 136 LISRNKLMVDKENIIGKGHFGTVYNGEYITSEISKLNGNPIKRKVAIKTLSKIEDTESVE 195
Query: 74 XXXXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPA 133
EGL + NVLT + ++ P+++ H +L +F+ + P
Sbjct: 196 KFLKEGLMMSDFHDENVLTLIGISWDDDGAPMVVLPYMMHG-DLLQFIRK----PSNNPT 250
Query: 134 TRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCL 193
++LV G Q G+ YL QRFVH D+AARNC+++E +KV D GLARD++ +Y+
Sbjct: 251 VKDLVGFGLQACKGMCYLASQRFVHRDLAARNCMLNETYVVKVADFGLARDIYEKEYYKP 310
Query: 194 GDNENR-PVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNG 252
++ R PVKWMA E+L Q ++ +DVWS GI LWEL T G +P ++DA DV ++
Sbjct: 311 HEHAGRMPVKWMALESLQQQTFTIKTDVWSFGILLWELLTRGVTPYPDVDAFDVVNYILD 370
Query: 253 GYRPSQPHNCPDEL 266
G R QP CPD L
Sbjct: 371 GRRLRQPQYCPDPL 384
>UniRef50_P30530 Cluster: Tyrosine-protein kinase receptor UFO
precursor; n=37; Euteleostomi|Rep: Tyrosine-protein
kinase receptor UFO precursor - Homo sapiens (Human)
Length = 887
Score = 145 bits (351), Expect = 1e-33
Identities = 84/256 (32%), Positives = 133/256 (51%), Gaps = 8/256 (3%)
Query: 18 EQLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXX-XXXXXXXXX 76
E+LR + R + L + EG FG + +G + D +V VKT
Sbjct: 517 EKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFL 576
Query: 77 XEGLRLYGLVHANVLTPMAACAEEARK-----PLLIYCCPSHSSNLKRFLSSCRLGQQSA 131
E + + H NV+ + C + + + P++I H +L FL RLG Q
Sbjct: 577 SEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHG-DLHSFLLYSRLGDQPV 635
Query: 132 PA-TRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDY 190
T+ LV A +A G+ YL +RF+H D+AARNC+++E + + V D GL++ ++ DY
Sbjct: 636 YLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDY 695
Query: 191 HCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFL 250
+ G PVKW+A E+L Y++ SDVWS G+T+WE+AT G +P ++ +++ +L
Sbjct: 696 YRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYL 755
Query: 251 NGGYRPSQPHNCPDEL 266
G R QP +C D L
Sbjct: 756 RQGNRLKQPADCLDGL 771
>UniRef50_Q4SR43 Cluster: Chromosome 11 SCAF14528, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 11 SCAF14528, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1373
Score = 143 bits (346), Expect = 5e-33
Identities = 72/191 (37%), Positives = 113/191 (59%), Gaps = 7/191 (3%)
Query: 78 EGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATREL 137
EG+ + G H NVL+ + + PL++ H +L+ F+ C ++ P ++L
Sbjct: 1140 EGIIMKGFHHCNVLSLLGILLPQEGLPLVVLPYMKHG-DLRHFIR-C---EKRNPTVKDL 1194
Query: 138 VDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNE 197
+ G QVA G+ YL ++FVH D+AARNC++DE +KV D G+ARD+ +Y+ + ++
Sbjct: 1195 IGFGLQVATGMEYLAQKKFVHRDLAARNCMLDESYTVKVADFGMARDVLDKEYYSVQNHR 1254
Query: 198 NR--PVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYR 255
PVKWMA E+L +++ SDVWS G+ +WE+ T G+SP ++D D+ +L G R
Sbjct: 1255 KAKLPVKWMAIESLQTQKFTPKSDVWSFGVLMWEMLTRGASPYPDVDPYDITHYLLRGRR 1314
Query: 256 PSQPHNCPDEL 266
QP CPD L
Sbjct: 1315 LPQPQFCPDPL 1325
>UniRef50_Q008W6 Cluster: Gamma-carboxyglutamic acid protein 1; n=2;
Ascidiacea|Rep: Gamma-carboxyglutamic acid protein 1 -
Ciona intestinalis (Transparent sea squirt)
Length = 556
Score = 142 bits (343), Expect = 1e-32
Identities = 89/267 (33%), Positives = 131/267 (49%), Gaps = 10/267 (3%)
Query: 6 QTVTKDRV-TDPAEQLRVLTTSRSNIRLEILIHEGTFGRIYKGVFK-KGDVYEEVMVKTX 63
+T DR D A L R ++L +I G FG +Y+G + + + + +V VK+
Sbjct: 147 ETPLMDRFDNDLAVGLSECYVERERLQLGEVITSGNFGDVYRGKLRSRQNTWHDVAVKSL 206
Query: 64 XXXXXXXXXXXXXXEGLRLYGLVHANVLTPMAACA----EEARKPLLIYCCPSHSSNLKR 119
EG+ + GL H NVL + C E + LI + +L+
Sbjct: 207 KSLENHEDVEKFLREGVMMRGLDHRNVLALIGVCVDGEVERLQTSPLIILPFMENGDLRT 266
Query: 120 FLSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDN 179
FL R G + L+ VA G+ YL ++FVH D+AARNC+VD+ +KV D
Sbjct: 267 FL---RDGNNVLTVLK-LLKFCKDVAMGMEYLAEKKFVHRDLAARNCMVDKNWCVKVADF 322
Query: 180 GLARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLA 239
GL+RDLF DY+ P+KWM PE++ +Y SDVWS GI WE+ T G+ P
Sbjct: 323 GLSRDLFDRDYYRSSVKTQLPLKWMPPESIKYGRYGEKSDVWSYGIVCWEIMTRGAIPYP 382
Query: 240 ELDAADVGAFLNGGYRPSQPHNCPDEL 266
+ A + +L+ G R +P CP +L
Sbjct: 383 TVQAVAILQYLSEGNRMERPECCPHKL 409
>UniRef50_Q9Y1Y9 Cluster: Protein tyrosine kinase; n=3; Metazoa|Rep:
Protein tyrosine kinase - Ephydatia fluviatilis
Length = 2069
Score = 141 bits (341), Expect = 2e-32
Identities = 79/248 (31%), Positives = 122/248 (49%), Gaps = 10/248 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKG----VFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRL 82
R N++LE I G FG +++G + G V VKT E +
Sbjct: 1699 RGNLKLENFIDRGEFGEVFQGTATDILGPGTGPIPVAVKTLRKGAIIEEQKKFLAEAALM 1758
Query: 83 YGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPAT-RELVDLG 141
H N++ + C E +++ P +L FL ++ + T +EL+ +
Sbjct: 1759 GNFNHPNIVKVLGVCVENDPVYIIMELMPG--GDLLHFLRDAKVERGPPLLTVKELIQIA 1816
Query: 142 AQVACGLSYLHVQRFVHADVAARNCVVDEKLR---LKVTDNGLARDLFPDDYHCLGDNEN 198
VA G YL F+H D+AARNC+V K +K+ D GLA+DL+ DY+ +
Sbjct: 1817 LDVAQGCHYLQQTHFIHRDLAARNCLVSSKGADRVVKIGDFGLAKDLYSSDYYQVEGQRK 1876
Query: 199 RPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQ 258
PV+WMAPE LLQ +++ SDVWS G+ +WE+ T G+ P L+ +V F+ R +
Sbjct: 1877 LPVRWMAPEALLQGKFNMESDVWSFGVLMWEIMTFGNQPYPALNNQEVLQFVTAEGRLQK 1936
Query: 259 PHNCPDEL 266
P NCP ++
Sbjct: 1937 PENCPGKI 1944
>UniRef50_P06213 Cluster: Insulin receptor precursor (EC 2.7.10.1)
(IR) (CD220 antigen) [Contains: Insulin receptor subunit
alpha; Insulin receptor subunit beta]; n=100;
Euteleostomi|Rep: Insulin receptor precursor (EC
2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin
receptor subunit alpha; Insulin receptor subunit beta] -
Homo sapiens (Human)
Length = 1382
Score = 141 bits (341), Expect = 2e-32
Identities = 80/250 (32%), Positives = 132/250 (52%), Gaps = 12/250 (4%)
Query: 26 SRSNIRLEILIHEGTFGRIYKGVFK---KGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRL 82
SR I L + +G+FG +Y+G + KG+ V VKT E +
Sbjct: 1019 SREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVM 1078
Query: 83 YGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQS-----APATREL 137
G +V+ + + + L++ +H +LK +L S R ++ P +E+
Sbjct: 1079 KGFTCHHVVR-LLGVVSKGQPTLVVMELMAHG-DLKSYLRSLRPEAENNPGRPPPTLQEM 1136
Query: 138 VDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNE 197
+ + A++A G++YL+ ++FVH D+AARNC+V +K+ D G+ RD++ DY+ G
Sbjct: 1137 IQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKG 1196
Query: 198 NRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAF-LNGGYRP 256
PV+WMAPE+L ++T+SD+WS G+ LWE+ +L P L V F ++GGY
Sbjct: 1197 LLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYL- 1255
Query: 257 SQPHNCPDEL 266
QP NCP+ +
Sbjct: 1256 DQPDNCPERV 1265
>UniRef50_O97191 Cluster: Tyrosine-protein kinase receptor; n=1;
Geodia cydonium|Rep: Tyrosine-protein kinase receptor -
Geodia cydonium (Sponge)
Length = 570
Score = 140 bits (338), Expect = 4e-32
Identities = 87/259 (33%), Positives = 130/259 (50%), Gaps = 14/259 (5%)
Query: 20 LRVLTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVYE---EVMVKTXXXXXXXXXXXXXX 76
L+ L + + L + EG FGR+YKG K GD + EV +KT
Sbjct: 259 LKGLLLAEDQLILTESLGEGAFGRVYKGSMKTGDDDDRTVEVAIKTLKDISQQENIDNFV 318
Query: 77 XEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPAT-- 134
E + + G H NVL + C + + LI + +L+ +L S R + T
Sbjct: 319 QESILMLGFNHPNVLELLGVCFDTTDRHPLIVLPFMANGDLRSYLMSKRDPSVTTKFTHF 378
Query: 135 -------RELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFP 187
R LV + +VA G+ YL FVH D+AARNC+V +L ++V D GL+RD++
Sbjct: 379 PQGLDEERALV-MCLEVARGMEYLSNSSFVHRDLAARNCMVSGELTVRVADFGLSRDVYS 437
Query: 188 DDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVG 247
DY+ +G PVKWMAPE+L N ++ SDVWS G+ WE+ +L +P + ++
Sbjct: 438 KDYYRMGTKTMLPVKWMAPESLADNIFTVKSDVWSFGVVCWEVFSL-VAPYPGIGNHEMS 496
Query: 248 AFLNGGYRPSQPHNCPDEL 266
++ GG R P CP E+
Sbjct: 497 DYIGGGRRLKIPRLCPREI 515
>UniRef50_UPI0000D55DFF Cluster: PREDICTED: similar to Insulin-like
growth factor 1 receptor precursor (Insulin-like growth
factor I receptor) (IGF-I receptor) (CD221 antigen); n=1;
Tribolium castaneum|Rep: PREDICTED: similar to
Insulin-like growth factor 1 receptor precursor
(Insulin-like growth factor I receptor) (IGF-I receptor)
(CD221 antigen) - Tribolium castaneum
Length = 1277
Score = 139 bits (337), Expect = 6e-32
Identities = 76/240 (31%), Positives = 120/240 (50%), Gaps = 4/240 (1%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLV 86
R++I + + +G+FG +Y+G+ K +KT EG +
Sbjct: 917 RNDIEIIRELGKGSFGTVYEGLIKSRQY--PCAIKTISEKSSISSKMEFLNEGSVMKSFS 974
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVAC 146
+ + + +P +I +LK +L CR G T E+ + +++A
Sbjct: 975 ETHHVIKLLGIVSRGDRPFVIMELMERG-DLKSYLRRCR-GPSQNLTTNEIYRMASEIAD 1032
Query: 147 GLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAP 206
G++YL V++FVH D+AARNC+V +K+ D G+ARD++ DY+ G P++WMAP
Sbjct: 1033 GMAYLSVKKFVHRDLAARNCMVAADRTVKIGDFGMARDIYETDYYRKGTAGLLPIRWMAP 1092
Query: 207 ETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
E+L ++T SDVWS G+ LWE+ATL P L A +V F+ G P C D L
Sbjct: 1093 ESLADGVFTTDSDVWSYGVVLWEMATLAELPYQGLGAEEVLQFVTSGRTLDMPPQCSDLL 1152
>UniRef50_O73798 Cluster: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (xIGF- 1R) (xIGFR) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain]; n=25;
Euteleostomi|Rep: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (xIGF- 1R) (xIGFR) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain] -
Xenopus laevis (African clawed frog)
Length = 1358
Score = 139 bits (337), Expect = 6e-32
Identities = 77/248 (31%), Positives = 127/248 (51%), Gaps = 10/248 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFK---KGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLY 83
R I + + +G+FG +Y+G+ K K + +V +KT E +
Sbjct: 992 REKITMNRELGQGSFGMVYEGIAKGVVKDEAETKVAIKTVNEAASMRERIEFLNEASVMK 1051
Query: 84 GLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQS-----APATRELV 138
+V+ + ++ +P L+ +LK +L S R +S P+ ++++
Sbjct: 1052 EFNCHHVVRLLGVVSQG--QPTLVIMELMTRGDLKSYLRSLRPDTESNSGQPTPSLKKMI 1109
Query: 139 DLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNEN 198
+ ++A G+SYL+ +FVH D+AARNC+V E +K+ D G+ RD++ DY+ G
Sbjct: 1110 QMAGEIADGMSYLNANKFVHRDLAARNCMVTEDFTVKIGDFGMTRDIYETDYYRKGGKGL 1169
Query: 199 RPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQ 258
PV+WM+PE+L ++T SDVWS G+ LWE+ATL P + V F+ G +
Sbjct: 1170 LPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFVMEGGLLEK 1229
Query: 259 PHNCPDEL 266
P NCPD L
Sbjct: 1230 PDNCPDML 1237
>UniRef50_P00522 Cluster: Tyrosine-protein kinase Abl; n=5;
Eumetazoa|Rep: Tyrosine-protein kinase Abl - Drosophila
melanogaster (Fruit fly)
Length = 1620
Score = 138 bits (335), Expect = 1e-31
Identities = 84/240 (35%), Positives = 124/240 (51%), Gaps = 10/240 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLV 86
R++I ++ + G +G +Y+ V+K+ V VKT E + +
Sbjct: 368 RTDIMMKHKLGGGQYGEVYEAVWKRYG--NTVAVKTLKEDTMALKDFLE--EAAIMKEMK 423
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVAC 146
H N++ + C E P I NL FL S G+++ A L+ + Q+A
Sbjct: 424 HPNLVQLIGVCTREP--PFYIITEFMSHGNLLDFLRSA--GRETLDAVA-LLYMATQIAS 478
Query: 147 GLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAP 206
G+SYL + ++H D+AARNC+V + +KV D GLAR L DD + P+KW AP
Sbjct: 479 GMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLAR-LMRDDTYTAHAGAKFPIKWTAP 537
Query: 207 ETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
E L N++ST SDVW+ G+ LWE+AT G SP +D DV L+ GYR +P CP E+
Sbjct: 538 EGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEV 597
>UniRef50_Q25410 Cluster: Putative molluscan insulin-related
peptide(s) receptor precursor (EC 2.7.10.1) [Contains:
Putative molluscan insulin-related peptide(s) receptor
alpha chain; Putative molluscan insulin-related
peptide(s) receptor beta chain]; n=2; Coelomata|Rep:
Putative molluscan insulin-related peptide(s) receptor
precursor (EC 2.7.10.1) [Contains: Putative molluscan
insulin-related peptide(s) receptor alpha chain; Putative
molluscan insulin-related peptide(s) receptor beta chain]
- Lymnaea stagnalis (Great pond snail)
Length = 1607
Score = 137 bits (331), Expect = 3e-31
Identities = 78/248 (31%), Positives = 127/248 (51%), Gaps = 10/248 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFK--KGDVYEE--VMVKTXXXXXXXXXXXXXXXEGLRL 82
R I+L + +G+FG +Y+GV K + D EE V VKT E +
Sbjct: 1034 RDKIKLIKELGQGSFGMVYEGVAKGIRDDPNEEIPVAVKTVNDRASFSDRREFLKEATTM 1093
Query: 83 YGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSA----PATRELV 138
H + + + + P L+ +LK +L R + P +++
Sbjct: 1094 KEF-HCHHVVKLLGVVSTGQ-PALVIMELMALGDLKNYLRGHRPDEDHPGVMPPHLLDIL 1151
Query: 139 DLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNEN 198
+ ++A G++YL ++FVH D+AARNC+V E+ +K+ D G+ RD++ DY+ G
Sbjct: 1152 QMAGEIADGMAYLADKKFVHRDLAARNCMVSEERTVKIGDFGMTRDIYETDYYRKGGKGM 1211
Query: 199 RPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQ 258
PV+WMAPE+L +++ SDVWS G+ +WE+ TL + P L +V F++ GY
Sbjct: 1212 LPVRWMAPESLKDGVFTSLSDVWSYGVVMWEMVTLAAQPYQGLSNEEVVKFISDGYIMEL 1271
Query: 259 PHNCPDEL 266
P NCP+E+
Sbjct: 1272 PENCPNEM 1279
>UniRef50_Q7Q0F6 Cluster: Tyrosine-protein kinase receptor; n=2;
Cellia|Rep: Tyrosine-protein kinase receptor - Anopheles
gambiae str. PEST
Length = 1318
Score = 136 bits (329), Expect = 5e-31
Identities = 79/244 (32%), Positives = 127/244 (52%), Gaps = 8/244 (3%)
Query: 30 IRLEILIHEGTFGRIYKGVFKK--GDVYEEVMVKTXXXXXXXXXXXXXXXEG--LRLYGL 85
I+LE L +G+FG +YKG+ K DV +KT E ++ +
Sbjct: 994 IQLEEL-GQGSFGMVYKGIMTKLGNDVNVPCAIKTVTENATERERDSFLIEATIMKEFHT 1052
Query: 86 VHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAP---ATRELVDLGA 142
H L + + + + + S L+R G++S+P +++ +
Sbjct: 1053 HHVVRLYGVVSVGQPTLVIMELMANGDLKSYLRRHRPDYENGEESSPQPPTLKQIYQMAI 1112
Query: 143 QVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVK 202
++A G++YL ++FVH D+AARNC+V E L +K+ D G+ RD++ DY+ G PV+
Sbjct: 1113 EIADGMAYLAAKKFVHRDLAARNCMVAEDLTVKIGDFGMTRDIYETDYYRKGTKGFLPVR 1172
Query: 203 WMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNC 262
WMAPE+L +S++SDV+S G+ LWE+ATL S P L V ++ G +P NC
Sbjct: 1173 WMAPESLKDGMFSSSSDVFSYGVVLWEMATLASQPYQGLTNDQVLRYVIDGGVMERPENC 1232
Query: 263 PDEL 266
PD+L
Sbjct: 1233 PDKL 1236
>UniRef50_Q9PVZ4 Cluster: Insulin receptor precursor (EC 2.7.10.1)
(IR) (Xe-InsR) (XTK-1b) [Contains: Insulin receptor
subunit alpha; Insulin receptor subunit beta]; n=6;
Euteleostomi|Rep: Insulin receptor precursor (EC
2.7.10.1) (IR) (Xe-InsR) (XTK-1b) [Contains: Insulin
receptor subunit alpha; Insulin receptor subunit beta] -
Xenopus laevis (African clawed frog)
Length = 1362
Score = 136 bits (329), Expect = 5e-31
Identities = 76/248 (30%), Positives = 126/248 (50%), Gaps = 10/248 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFK---KGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLY 83
R I L + +G+FG +Y+G+ K KG+ V VKT E +
Sbjct: 1009 RDKINLLRELGQGSFGMVYEGIAKDIIKGEPEVRVAVKTVNESASLRERIEFLNEASVMK 1068
Query: 84 GLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQS-----APATRELV 138
+ + + + + + L+I +H +LK +L S R ++ AP +E++
Sbjct: 1069 AF-NCHHVVRLLGVVSKGQPTLVIMELMAHG-DLKSYLRSLRPDAENNPGRLAPTLKEII 1126
Query: 139 DLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNEN 198
+ A+++ G++YL+ ++FVH D+AARNC+V + +K+ D G+ RD++ DY+ G
Sbjct: 1127 QMAAEISDGMAYLNAKKFVHRDLAARNCMVADDYAVKIGDFGMTRDIYETDYYRKGGKGL 1186
Query: 199 RPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQ 258
PV+WM+PE+L ++ SDVWS G+ LWE+ +L P L V F+ G
Sbjct: 1187 LPVRWMSPESLKDGVFTAFSDVWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGSLDH 1246
Query: 259 PHNCPDEL 266
P NCP L
Sbjct: 1247 PENCPPRL 1254
>UniRef50_UPI0000DB6DD4 Cluster: PREDICTED: similar to Insulin-like
growth factor 1 receptor precursor (Insulin-like growth
factor I receptor) (IGF-I receptor); n=1; Apis
mellifera|Rep: PREDICTED: similar to Insulin-like growth
factor 1 receptor precursor (Insulin-like growth factor
I receptor) (IGF-I receptor) - Apis mellifera
Length = 855
Score = 136 bits (328), Expect = 7e-31
Identities = 80/246 (32%), Positives = 121/246 (49%), Gaps = 8/246 (3%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFK---KGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLY 83
R I + + GTFG +Y+G+ K KG VKT E +
Sbjct: 327 REKIEMLRSLGTGTFGMVYEGIAKDIVKGKSEVRCAVKTVNKDATDRERIEFLNEASVMK 386
Query: 84 GLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSS---CRLGQQSAPATRELVDL 140
G +V+ + +P L+ + +LKR+L S C + P ++ +
Sbjct: 387 GFDAHHVVKLLGVVTRG--QPTLVIMELMVNGDLKRYLRSHRPCENMSNAPPKLDRILQM 444
Query: 141 GAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRP 200
++A G++YL ++FVH D+AARNC+V E L +KV D G+ RD++ DY+ G P
Sbjct: 445 AIEIADGMAYLSTKKFVHRDLAARNCMVAEDLTVKVGDFGMTRDIYERDYYRKGSKGLLP 504
Query: 201 VKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPH 260
V+WMAPE+L +S+ SDVWS G+ LWE+ T S P L V ++ G +P
Sbjct: 505 VRWMAPESLKDGVFSSYSDVWSYGVVLWEMVTFASQPYQGLSNEQVLRYVIEGGVMERPE 564
Query: 261 NCPDEL 266
NCP+ L
Sbjct: 565 NCPELL 570
>UniRef50_UPI0000D57494 Cluster: PREDICTED: similar to insulin
receptor; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to insulin receptor - Tribolium castaneum
Length = 1351
Score = 136 bits (328), Expect = 7e-31
Identities = 78/250 (31%), Positives = 129/250 (51%), Gaps = 12/250 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFK--KGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYG 84
R I L + +G+FG +Y+G+ + +G + VKT E +
Sbjct: 977 RKKIELIRELGQGSFGMVYEGIAQDVRGKAQIKCAVKTVNEHATNRERLEFLNEASVMKA 1036
Query: 85 LVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQ--------SAPATRE 136
A+V+ + ++ +P L+ + +LK +L S R + P ++
Sbjct: 1037 FDTAHVVRLLGVVSQG--QPTLVIMELMANGDLKTYLRSHRPDAEVYDPATAKQPPTLKQ 1094
Query: 137 LVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDN 196
++ + ++A G++YL ++FVH D+AARNC+V E L +K+ D G+ RD++ DY+ G
Sbjct: 1095 ILQMAIEIADGMAYLSAKKFVHRDLAARNCMVAEDLTVKIGDFGMTRDIYETDYYRKGTK 1154
Query: 197 ENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRP 256
PV+WMAPE+L +++ SDVWS G+ LWE+ATL S P L V ++ G
Sbjct: 1155 GLLPVRWMAPESLKDGVFTSNSDVWSYGVVLWEMATLASQPYQGLSNDQVLRYVIDGGVM 1214
Query: 257 SQPHNCPDEL 266
+P NCPD+L
Sbjct: 1215 ERPENCPDKL 1224
>UniRef50_Q4RXB0 Cluster: Chromosome 11 SCAF14979, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 11 SCAF14979, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1078
Score = 135 bits (327), Expect = 1e-30
Identities = 77/212 (36%), Positives = 115/212 (54%), Gaps = 23/212 (10%)
Query: 78 EGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHS-------SNLKRFLSSCRLGQQS 130
EGL + G H N+L+ + + PL++ H S + F+ C L +Q
Sbjct: 791 EGLIMKGFDHPNILSLLGIMLPKEGLPLVVLPYMKHGDVRHFIRSEKRVFICICGLTKQE 850
Query: 131 A--------------PATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKV 176
P ++L+ G QVA G+ YL ++FVH D+AARNC++DE +KV
Sbjct: 851 DNRELCLTFLCLPQNPTVKDLIGFGLQVAKGMEYLAQKKFVHRDLAARNCMLDETYTVKV 910
Query: 177 TDNGLARDLFPDDYHCLGDNEN--RPVKWMAPETLLQNQYSTASDVWSLGITLWELATLG 234
D G+ARD++ +Y+ + D++ PVKWMA E+L +++ SDVWS GI +WEL T G
Sbjct: 911 ADFGMARDIYDKEYYSIQDHKQVKLPVKWMALESLQTQKFTIKSDVWSYGILMWELLTRG 970
Query: 235 SSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
+SP ++D D+ +L G R QP CPD L
Sbjct: 971 ASPYPDVDPYDITHYLLKGRRLPQPQFCPDTL 1002
>UniRef50_P08069 Cluster: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (Insulin-like growth factor I
receptor) (IGF-I receptor) (CD221 antigen) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain]; n=47;
Euteleostomi|Rep: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (Insulin-like growth factor I
receptor) (IGF-I receptor) (CD221 antigen) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain] - Homo
sapiens (Human)
Length = 1367
Score = 135 bits (327), Expect = 1e-30
Identities = 77/249 (30%), Positives = 126/249 (50%), Gaps = 10/249 (4%)
Query: 26 SRSNIRLEILIHEGTFGRIYKGVFK---KGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRL 82
+R I + + +G+FG +Y+GV K K + V +KT E +
Sbjct: 995 AREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVM 1054
Query: 83 YGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQS-----APATREL 137
+V+ + ++ +P L+ +LK +L S R ++ P+ ++
Sbjct: 1055 KEFNCHHVVRLLGVVSQG--QPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKM 1112
Query: 138 VDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNE 197
+ + ++A G++YL+ +FVH D+AARNC+V E +K+ D G+ RD++ DY+ G
Sbjct: 1113 IQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKG 1172
Query: 198 NRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPS 257
PV+WM+PE+L ++T SDVWS G+ LWE+ATL P L V F+ G
Sbjct: 1173 LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLD 1232
Query: 258 QPHNCPDEL 266
+P NCPD L
Sbjct: 1233 KPDNCPDML 1241
>UniRef50_P08922 Cluster: Proto-oncogene tyrosine-protein kinase ROS
precursor; n=20; Eumetazoa|Rep: Proto-oncogene
tyrosine-protein kinase ROS precursor - Homo sapiens
(Human)
Length = 2347
Score = 134 bits (325), Expect = 2e-30
Identities = 82/251 (32%), Positives = 118/251 (47%), Gaps = 13/251 (5%)
Query: 27 RSNIRLEILIHEGTFGRIYKG----VFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRL 82
R + L +L+ G FG +Y+G + G +V VKT E +
Sbjct: 1942 REKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLM 2001
Query: 83 YGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATR--ELVDL 140
H N+L + C +P I +L +L R+ P +LVDL
Sbjct: 2002 SKFNHPNILKQLGVCL--LNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDL 2059
Query: 141 GAQVACGLSYLHVQRFVHADVAARNCVVDEK-----LRLKVTDNGLARDLFPDDYHCLGD 195
++ G YL F+H D+AARNC+V K +K+ D GLARD++ +DY+
Sbjct: 2060 CVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRG 2119
Query: 196 NENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYR 255
PV+WMAPE+L+ ++T SDVWS GI +WE+ TLG P DV ++ G R
Sbjct: 2120 EGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGR 2179
Query: 256 PSQPHNCPDEL 266
P NCPD+L
Sbjct: 2180 LEPPRNCPDDL 2190
>UniRef50_UPI0000519AF4 Cluster: PREDICTED: similar to Abl tyrosine
kinase CG4032-PA; n=1; Apis mellifera|Rep: PREDICTED:
similar to Abl tyrosine kinase CG4032-PA - Apis
mellifera
Length = 1439
Score = 134 bits (324), Expect = 2e-30
Identities = 84/241 (34%), Positives = 122/241 (50%), Gaps = 10/241 (4%)
Query: 26 SRSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGL 85
+R++I + + G +G +Y+ V+K+ ++ V VKT E + +
Sbjct: 285 NRTDIVMRHKLGGGQYGDVYEAVWKRYNM--TVAVKTLKEDTMALKDFLE--EAAIMKEM 340
Query: 86 VHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVA 145
H N++ + C E P I NL +L + Q +A L+ + Q+A
Sbjct: 341 KHRNLVQLLGVCTREP--PFYIITEFMSKGNLLDYLRNESKHQINAVV---LMHMATQIA 395
Query: 146 CGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMA 205
G+SYL + F+H D+AARNC+V E +KV D GLAR L DD + P+KW A
Sbjct: 396 SGMSYLESRNFIHRDLAARNCLVGENHLVKVADFGLAR-LMRDDTYTAHAGAKFPIKWTA 454
Query: 206 PETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDE 265
PE L N++ST SDVW+ GI LWE+AT G SP +D DV L GYR P CP +
Sbjct: 455 PEGLAYNKFSTKSDVWAFGILLWEIATYGMSPYPGVDLTDVYHMLEKGYRMECPPGCPPK 514
Query: 266 L 266
+
Sbjct: 515 V 515
>UniRef50_Q4H3B8 Cluster: Tyrosine-protein kinase receptor; n=1;
Ciona intestinalis|Rep: Tyrosine-protein kinase receptor
- Ciona intestinalis (Transparent sea squirt)
Length = 465
Score = 134 bits (324), Expect = 2e-30
Identities = 81/246 (32%), Positives = 127/246 (51%), Gaps = 11/246 (4%)
Query: 29 NIRLEILIHEGTFGRIYKGVFK---KGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGL 85
N+ L I G FG++Y+G+ K KG +V VKT E +
Sbjct: 98 NVELMDEIGHGHFGKVYEGLAKQVVKGQPKTKVAVKTLHGNESISKRMEFLKEASVMKAF 157
Query: 86 VHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCR----LGQQSAPATRELVDLG 141
+V+ + +++P++I + +LK +L S R + + P+ ++ + +
Sbjct: 158 NSHHVVR-LLGVVSMSKRPMVIMEFMA-KGDLKTYLRSTRPDAEIRKGDPPSLQQKLQMC 215
Query: 142 AQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPV 201
++A G+SYL ++VH D+AARNC+V E L +K+ D GL RD++ DY+ + PV
Sbjct: 216 GEIADGMSYLSETKYVHRDLAARNCLVHEDLTVKIGDFGLTRDVYETDYYRIDSRGILPV 275
Query: 202 KWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAF-LNGGYRPSQPH 260
+WMAPE+L + + SDVWS GI LWE+ATL P V F ++GGY QP
Sbjct: 276 RWMAPESLKDGVFDSRSDVWSFGIVLWEIATLAEQPYQGQQHDQVTRFVIDGGYM-EQPK 334
Query: 261 NCPDEL 266
CP +L
Sbjct: 335 ECPSKL 340
>UniRef50_UPI00015B4B0F Cluster: PREDICTED: similar to
proto-oncogene tyrosine-protein kinase abl1; n=1;
Nasonia vitripennis|Rep: PREDICTED: similar to
proto-oncogene tyrosine-protein kinase abl1 - Nasonia
vitripennis
Length = 1522
Score = 134 bits (323), Expect = 3e-30
Identities = 84/241 (34%), Positives = 122/241 (50%), Gaps = 10/241 (4%)
Query: 26 SRSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGL 85
+R++I + + G +G +Y+ V+K+ ++ V VKT E + +
Sbjct: 286 NRTDIVMRHKLGGGQYGDVYEAVWKRYNM--TVAVKTLKEDTMALKDFLE--EAAIMKEM 341
Query: 86 VHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVA 145
H N++ + C E P I NL +L + Q +A L+ + Q+A
Sbjct: 342 KHRNLVQLIGVCTREP--PFYIITEFMSKGNLLDYLRNESKHQINAVV---LMHMATQIA 396
Query: 146 CGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMA 205
G+SYL + F+H D+AARNC+V E +KV D GLAR L DD + P+KW A
Sbjct: 397 SGMSYLESRNFIHRDLAARNCLVGESHLVKVADFGLAR-LMRDDTYTAHAGAKFPIKWTA 455
Query: 206 PETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDE 265
PE L N++ST SDVW+ GI LWE+AT G SP +D DV L GYR P CP +
Sbjct: 456 PEGLAYNKFSTKSDVWAFGILLWEIATYGMSPYPGVDLTDVYHMLEKGYRMECPPGCPPK 515
Query: 266 L 266
+
Sbjct: 516 V 516
>UniRef50_Q7PWP1 Cluster: ENSANGP00000013218; n=2; Culicidae|Rep:
ENSANGP00000013218 - Anopheles gambiae str. PEST
Length = 861
Score = 133 bits (321), Expect = 5e-30
Identities = 84/251 (33%), Positives = 126/251 (50%), Gaps = 12/251 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKGV---FKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLY 83
R+N+ L+ + EG FG++ KG + V VK E L
Sbjct: 484 RTNLILDATLGEGEFGKVLKGFATDLPEKPGITTVAVKMLKTGANSVELLALLSEYQLLQ 543
Query: 84 GLVHANVLTPMAACAEEARKPLLI--YCCPSHSSN---LKRFLSSCRLGQQSA--PAT-R 135
+ H NV+ + AC + PLLI YC N L R L ++A P T +
Sbjct: 544 EVNHPNVIRLLGACTK-GDSPLLIIEYCQYGSLKNYLRLSRKLEVLNADYENAVEPITVK 602
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGD 195
+++ Q++ G++YL + VH D+AARN ++ E K++D GL RD++ DD +
Sbjct: 603 DILSFAWQISKGMAYLTDIKLVHRDLAARNVLLAEGKVCKISDFGLTRDVYEDDAYLKKS 662
Query: 196 NENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYR 255
+ PVKWMAPE+L + Y+T SDVW+ G+ WEL TLG+SP + ++ L GYR
Sbjct: 663 KDRVPVKWMAPESLADHIYTTKSDVWAFGVLCWELITLGASPYPGIPPQNLYNLLKQGYR 722
Query: 256 PSQPHNCPDEL 266
P NC +E+
Sbjct: 723 MECPKNCSEEI 733
>UniRef50_Q52V39 Cluster: Tyrosine-protein kinase receptor; n=2;
Branchiostoma floridae|Rep: Tyrosine-protein kinase
receptor - Branchiostoma floridae (Florida lancelet)
(Amphioxus)
Length = 797
Score = 133 bits (321), Expect = 5e-30
Identities = 84/261 (32%), Positives = 128/261 (49%), Gaps = 18/261 (6%)
Query: 17 AEQLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVYEE---VMVKTXXXXXXXXXXX 73
+++L + R I + EG FGR+Y G +K E+ V VKT
Sbjct: 497 SKELVIRHIQRDTIHFVGELGEGAFGRVYLGKCEKLKPDEDASLVAVKTLKEMSVEDARK 556
Query: 74 XXXXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSA-- 131
E L + H N++ C E +P L+ + +L +L S G +A
Sbjct: 557 DFDREAELLTNMQHENIVKFYGVCTEG--EPWLMIFEYMENGDLNNYLRSH--GPDAAFL 612
Query: 132 ---PATR------ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLA 182
PAT EL+ + QVA G+ Y+ Q FVH D+A RNC+V +KL +K+ D G++
Sbjct: 613 IKNPATHKELSIVELLQISVQVASGVEYMASQHFVHRDLATRNCLVGDKLVVKIGDFGMS 672
Query: 183 RDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELD 242
RD++ DY+ +G + PV+WM PE++L +++ SD+WS G+ LWE+ T G P EL
Sbjct: 673 RDIYSTDYYRVGGHTMLPVRWMPPESVLYRKFTIESDIWSFGVVLWEIFTFGKQPWYELA 732
Query: 243 AADVGAFLNGGYRPSQPHNCP 263
+V + G P CP
Sbjct: 733 NHEVIECITSGRLLGCPRGCP 753
>UniRef50_Q2LC18 Cluster: Tyrosine-protein kinase receptor; n=2;
Strongylocentrotus purpuratus|Rep: Tyrosine-protein
kinase receptor - Strongylocentrotus purpuratus (Purple
sea urchin)
Length = 1072
Score = 133 bits (321), Expect = 5e-30
Identities = 76/245 (31%), Positives = 128/245 (52%), Gaps = 10/245 (4%)
Query: 31 RLEIL--IHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLR---LYGL 85
+LEI+ + +G+FG +Y+G+ K EE + + E L + L
Sbjct: 698 KLEIIRELGKGSFGMVYEGLAKGILPEEEEISRVAIKSVQANASMRDRIEFLNEASVMKL 757
Query: 86 VHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQ----SAPATRELVDLG 141
+ A+ + + + + P + +LK +L + R Q S P +L+++
Sbjct: 758 IDAHNVVRLLGVVSKGQ-PTYVIMEFMAQGDLKNWLRARRPENQQDLPSVPTLEQLLNMA 816
Query: 142 AQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPV 201
A++A G+S+L +++VH D++ARNC+V + KV D GLARD++ DY+ P+
Sbjct: 817 AEIADGMSFLAARKYVHRDLSARNCLVSGEGTCKVADFGLARDIYQSDYYRKERGGMLPI 876
Query: 202 KWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHN 261
+WMAPE++ + +SDVWS GI LWE+ATLG P L + G ++ GG P N
Sbjct: 877 RWMAPESVKDGVFQASSDVWSFGILLWEMATLGELPYQGLSNEEAGEYIKGGNVLRPPEN 936
Query: 262 CPDEL 266
CP+++
Sbjct: 937 CPEKM 941
>UniRef50_UPI00015B5959 Cluster: PREDICTED: similar to insulin
receptor; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to insulin receptor - Nasonia vitripennis
Length = 1714
Score = 132 bits (320), Expect = 7e-30
Identities = 77/248 (31%), Positives = 123/248 (49%), Gaps = 10/248 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFK---KGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLY 83
R + L + G+FG +Y+G+ K KG VKT E +
Sbjct: 1126 RKKVHLLKELGNGSFGMVYEGIAKDVVKGKPEMRCAVKTVNENATDRERVEFLNEASVMK 1185
Query: 84 GLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSS-----CRLGQQSAPATRELV 138
G +V+ + ++ +P L+ + +LK +L S C + P ++
Sbjct: 1186 GFNTHHVVRLLGVVSQG--QPTLVVMELMVNGDLKTYLRSHRPDVCENFSRQPPTLNRIM 1243
Query: 139 DLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNEN 198
+ ++A G++YL ++FVH D+AARNC+V + L +K+ D G+ RD++ DY+ G
Sbjct: 1244 RMALEIADGMAYLAAKKFVHRDLAARNCMVSDDLTVKIGDFGMTRDVYETDYYRKGTKGL 1303
Query: 199 RPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQ 258
PV+WMAPE+L +++ SDVWS G+ LWE+ TL S P L V ++ G +
Sbjct: 1304 LPVRWMAPESLKDGVFTSFSDVWSYGVVLWEMVTLASQPYQGLSNDQVLRYVIDGGVMER 1363
Query: 259 PHNCPDEL 266
P NCPD L
Sbjct: 1364 PENCPDIL 1371
>UniRef50_Q5K4G5 Cluster: Receptor tyrosine kinase; n=1; Suberites
domuncula|Rep: Receptor tyrosine kinase - Suberites
domuncula (Sponge)
Length = 715
Score = 131 bits (317), Expect = 2e-29
Identities = 71/180 (39%), Positives = 103/180 (57%), Gaps = 4/180 (2%)
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVAC 146
H NV++ + A + + L++ C NL +FL S R +S + + V + +QVA
Sbjct: 447 HCNVVSFLGASVHKGKLHLIVEYC--ERGNLLQFLRSKRGDMKSPLSVQNQVAIASQVAN 504
Query: 147 GLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAP 206
G++YL +R +H D+AARN ++ + L LKV D GLAR ++ Y G + P+KWMAP
Sbjct: 505 GMAYLASKRCIHRDLAARNVLITKDLTLKVADFGLARKMYSSVYRPSG--KRLPIKWMAP 562
Query: 207 ETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
E +L ++ SDVWS GI LWE+ TLG +P A V + GYR QP CPD+L
Sbjct: 563 EGILDGVCTSKSDVWSFGILLWEIMTLGRTPYPGRSAHWVIRDIENGYRMPQPDGCPDKL 622
>UniRef50_P00521 Cluster: Tyrosine-protein kinase transforming
protein Abl; n=15; root|Rep: Tyrosine-protein kinase
transforming protein Abl - Abelson murine leukemia virus
Length = 746
Score = 131 bits (317), Expect = 2e-29
Identities = 78/240 (32%), Positives = 120/240 (50%), Gaps = 10/240 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLV 86
R++I ++ + G +G +Y+GV+KK + V VKT E + +
Sbjct: 125 RTDITMKHKLGGGQYGEVYEGVWKKYSL--TVAVKTLKEDTMEVEEFLK--EAAVMKEIK 180
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVAC 146
H N++ + C E P I NL +L C + SA L+ + Q++
Sbjct: 181 HPNLVQLLGVCTREP--PFYIITEFMTYGNLLDYLRECNRQEVSAVV---LLYMATQISS 235
Query: 147 GLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAP 206
+ YL + F+H D+AARNC+V E +KV D GL+R L D + P+KW AP
Sbjct: 236 AMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAP 294
Query: 207 ETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
E+L N++S SDVW+ G+ LWE+AT G SP +D + V L YR +P CP+++
Sbjct: 295 ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV 354
>UniRef50_Q6ZMQ8-3 Cluster: Isoform 3 of Q6ZMQ8 ; n=6;
Tetrapoda|Rep: Isoform 3 of Q6ZMQ8 - Homo sapiens
(Human)
Length = 879
Score = 131 bits (316), Expect = 2e-29
Identities = 75/221 (33%), Positives = 112/221 (50%), Gaps = 9/221 (4%)
Query: 36 IHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMA 95
I G FG+++ G G +V+VK E L H+N+L +A
Sbjct: 131 IGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLA 190
Query: 96 ACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQR 155
CAE L++ CP +LK +L SCR+ + AP R L + +VACG+ +LH
Sbjct: 191 QCAEVTPYLLVMEFCPL--GDLKGYLRSCRVAESMAPDPRTLQRMACEVACGVLHLHRNN 248
Query: 156 FVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPE-------T 208
FVH+D+A RNC++ L +K+ D GLA + +DY D P++W+APE
Sbjct: 249 FVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVHSN 308
Query: 209 LLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAF 249
LL + + +VWSLG+T+WEL LG+ P + V A+
Sbjct: 309 LLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAY 349
>UniRef50_Q70W09 Cluster: Receptor tyrosine kinase VIII; n=1; Ciona
intestinalis|Rep: Receptor tyrosine kinase VIII - Ciona
intestinalis (Transparent sea squirt)
Length = 895
Score = 131 bits (316), Expect = 2e-29
Identities = 72/194 (37%), Positives = 111/194 (57%), Gaps = 5/194 (2%)
Query: 78 EGLRLYGLVHANV--LTPMAACAEEARKPL--LIYCCPSHSSNLKRFLSSCRLGQQSAPA 133
EGLR+ L H NV L +A AE+ KP L+ + +L+ +L S R S
Sbjct: 602 EGLRMKDLDHPNVMALIGIAFTAEDLNKPASPLVVLPYMPNGDLRSYLFSMRTAGLSEKF 661
Query: 134 T-RELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHC 192
T ++L+ VA G+ YL + F+H D+AARNC++DE ++ V+D GL+R ++ + Y+
Sbjct: 662 TVQKLLLFALDVAKGMQYLSNRNFIHRDLAARNCMLDENYKVVVSDFGLSRTVYSESYYR 721
Query: 193 LGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNG 252
PVKWMA E+L N ++ SDVWS G+T+WE+ T+G SP + +V L
Sbjct: 722 QTHISKMPVKWMALESLADNIFTPLSDVWSFGVTVWEILTMGQSPYPGVGNHEVYQLLRN 781
Query: 253 GYRPSQPHNCPDEL 266
G R ++P +CP ++
Sbjct: 782 GTRLNKPEHCPSKV 795
>UniRef50_Q6ZMQ8 Cluster: Serine/threonine-protein kinase LMTK1;
n=19; Eutheria|Rep: Serine/threonine-protein kinase
LMTK1 - Homo sapiens (Human)
Length = 1374
Score = 131 bits (316), Expect = 2e-29
Identities = 75/221 (33%), Positives = 112/221 (50%), Gaps = 9/221 (4%)
Query: 36 IHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMA 95
I G FG+++ G G +V+VK E L H+N+L +A
Sbjct: 131 IGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLA 190
Query: 96 ACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQR 155
CAE L++ CP +LK +L SCR+ + AP R L + +VACG+ +LH
Sbjct: 191 QCAEVTPYLLVMEFCPL--GDLKGYLRSCRVAESMAPDPRTLQRMACEVACGVLHLHRNN 248
Query: 156 FVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPE-------T 208
FVH+D+A RNC++ L +K+ D GLA + +DY D P++W+APE
Sbjct: 249 FVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVHSN 308
Query: 209 LLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAF 249
LL + + +VWSLG+T+WEL LG+ P + V A+
Sbjct: 309 LLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAY 349
>UniRef50_P10447 Cluster: Tyrosine-protein kinase transforming
protein Abl; n=57; root|Rep: Tyrosine-protein kinase
transforming protein Abl - Feline sarcoma virus (strain
Hardy-Zuckerman 2)
Length = 439
Score = 130 bits (314), Expect = 4e-29
Identities = 77/240 (32%), Positives = 121/240 (50%), Gaps = 10/240 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLV 86
R++I ++ + G +G +Y+GV+KK + V VKT E + +
Sbjct: 188 RTDITMKHKLGGGQYGEVYEGVWKKYSL--TVAVKTLKEDTMEVEEFLK--EAAVMKEIK 243
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVAC 146
H N++ + C E P I NL +L C + +A L+ + Q++
Sbjct: 244 HPNLVQLLGVCTREP--PFYIITEFMTYGNLLDYLRECNRQEVNAVV---LLYMATQISS 298
Query: 147 GLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAP 206
+ YL + F+H D+AARNC+V E +KV D GL+R + D Y + P+KW AP
Sbjct: 299 AMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGTKF-PIKWTAP 357
Query: 207 ETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
E+L N++S SDVW+ G+ LWE+AT G SP +D + V L YR +P CP+++
Sbjct: 358 ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV 417
>UniRef50_P00519 Cluster: Proto-oncogene tyrosine-protein kinase
ABL1; n=35; root|Rep: Proto-oncogene tyrosine-protein
kinase ABL1 - Homo sapiens (Human)
Length = 1130
Score = 130 bits (314), Expect = 4e-29
Identities = 77/240 (32%), Positives = 120/240 (50%), Gaps = 10/240 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLV 86
R++I ++ + G +G +Y+GV+KK + V VKT E + +
Sbjct: 239 RTDITMKHKLGGGQYGEVYEGVWKKYSL--TVAVKTLKEDTMEVEEFLK--EAAVMKEIK 294
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVAC 146
H N++ + C E P I NL +L C + +A L+ + Q++
Sbjct: 295 HPNLVQLLGVCTREP--PFYIITEFMTYGNLLDYLRECNRQEVNAVV---LLYMATQISS 349
Query: 147 GLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAP 206
+ YL + F+H D+AARNC+V E +KV D GL+R L D + P+KW AP
Sbjct: 350 AMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAP 408
Query: 207 ETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
E+L N++S SDVW+ G+ LWE+AT G SP +D + V L YR +P CP+++
Sbjct: 409 ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV 468
>UniRef50_UPI0000D57520 Cluster: PREDICTED: similar to CG8250-PA; n=1;
Tribolium castaneum|Rep: PREDICTED: similar to CG8250-PA
- Tribolium castaneum
Length = 1284
Score = 130 bits (313), Expect = 5e-29
Identities = 77/245 (31%), Positives = 120/245 (48%), Gaps = 10/245 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKG--DVYE-EVMVKTXXXXXXXXXXXXXXXEGLRLY 83
R +RL + +G FG +Y+G +++ D E V VKT E L +
Sbjct: 817 REQLRLVKALGQGAFGEVYQGFYRQRPCDTVEMPVAVKTLPEMSTSQAEMDFLMEALIMS 876
Query: 84 GLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCR-LGQQSAPAT-RELVDLG 141
H N++ + C + + P I +LK FL R ++ +P T ++LV +
Sbjct: 877 KFNHPNIVHFIGVCFD--KHPRFIVLELLAGGDLKNFLRESRPKPERGSPLTMKDLVLIA 934
Query: 142 AQVACGLSYLHVQRFVHADVAARNCVVDEK---LRLKVTDNGLARDLFPDDYHCLGDNEN 198
VA G YL RF+H D+AARNC++ K +K+ D G++RD++ DY+ G
Sbjct: 935 VDVAKGCKYLEDNRFIHRDIAARNCLLTTKGPGRVVKIADFGMSRDVYRSDYYRKGGKAM 994
Query: 199 RPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQ 258
P+KWM PE L +++ +DVWS G+ LWE+ ++G P +V + G R
Sbjct: 995 LPIKWMPPEAFLDGIFTSKTDVWSFGVLLWEIMSMGYMPYTGCANREVMQLVTSGGRLDP 1054
Query: 259 PHNCP 263
P NCP
Sbjct: 1055 PANCP 1059
>UniRef50_P42684 Cluster: Tyrosine-protein kinase ABL2; n=38;
Euteleostomi|Rep: Tyrosine-protein kinase ABL2 - Homo
sapiens (Human)
Length = 1182
Score = 130 bits (313), Expect = 5e-29
Identities = 79/240 (32%), Positives = 118/240 (49%), Gaps = 10/240 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLV 86
R++I ++ + G +G +Y GV+KK + V VKT E + +
Sbjct: 285 RTDITMKHKLGGGQYGEVYVGVWKKYSL--TVAVKTLKEDTMEVEEFLK--EAAVMKEIK 340
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVAC 146
H N++ + C E P I NL +L C + +A L+ + Q++
Sbjct: 341 HPNLVQLLGVCTLEP--PFYIVTEYMPYGNLLDYLRECNREEVTAVV---LLYMATQISS 395
Query: 147 GLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAP 206
+ YL + F+H D+AARNC+V E +KV D GL+R L D + P+KW AP
Sbjct: 396 AMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAP 454
Query: 207 ETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
E+L N +S SDVW+ G+ LWE+AT G SP +D + V L GYR QP CP ++
Sbjct: 455 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 514
>UniRef50_Q7YT64 Cluster: Tyrosine-protein kinase receptor; n=1;
Crassostrea gigas|Rep: Tyrosine-protein kinase receptor
- Crassostrea gigas (Pacific oyster) (Crassostrea
angulata)
Length = 804
Score = 129 bits (312), Expect = 6e-29
Identities = 79/260 (30%), Positives = 131/260 (50%), Gaps = 24/260 (9%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEE-----VMVKTXXXXXXXXXXXXXXXEGLR 81
R I+L + +G+FG +Y+GV + D+Y + V VKT E R
Sbjct: 332 RDKIQLIRELGQGSFGMVYEGVAR--DLYGKGGEIKVAVKTVNEHATYRERMEFLSEASR 389
Query: 82 LYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQ------------ 129
+ +V+ + ++ +P L+ +LK FL R ++
Sbjct: 390 MKAFSCNHVVRLLGVVSDG--QPALLIMELMEKGDLKNFLRMHRPVEEDIDSTFAGIKEH 447
Query: 130 ---SAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLF 186
+ P + ++ + ++A G++YL ++FVH D+AARNC+V E L +K+ D G+ RD++
Sbjct: 448 ISRTPPTIKRIIQMAGEIADGMAYLADKKFVHRDLAARNCMVAEDLTVKIADFGMTRDIY 507
Query: 187 PDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADV 246
DY+ G PV+WMAPE+L +++ SDVWS G+ LWE+ATL + P L +V
Sbjct: 508 ETDYYRKGGKALLPVRWMAPESLKDGIFTSLSDVWSYGVVLWEMATLAAQPYQGLSNEEV 567
Query: 247 GAFLNGGYRPSQPHNCPDEL 266
++ G +P +CPD L
Sbjct: 568 LRYVLNGRVMEKPEDCPDRL 587
>UniRef50_UPI00015B51DA Cluster: PREDICTED: similar to
ENSANGP00000013218; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000013218 - Nasonia
vitripennis
Length = 972
Score = 129 bits (311), Expect = 8e-29
Identities = 82/256 (32%), Positives = 126/256 (49%), Gaps = 19/256 (7%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDV-----YEEVMVKTXXXXXXXXXXXXXXXEGLR 81
RS + +E ++ EG FGR+ + K D+ V VKT E
Sbjct: 498 RSRLSIEQVLGEGEFGRVLRA--KAQDIAGWQGQTTVAVKTLKEDASASELADLLSEYQL 555
Query: 82 LYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCR-LGQQSAPAT------ 134
L H NV+ + AC A P+ + + +L+ +L R L + P+
Sbjct: 556 LKEAQHPNVIRLLGACTT-AGGPIYLIIEFAEFGSLRNYLRRSRHLESEGRPSIDPVVNY 614
Query: 135 ----RELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDY 190
R+++ Q++ G++YL + VH D+AARN ++ K++D GL RD++ DD
Sbjct: 615 TITPRDILSFAWQISKGMAYLADIKLVHRDLAARNVLLGAGKVCKISDFGLTRDVYEDDA 674
Query: 191 HCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFL 250
+ PVKWMAPE+L + Y++ SDVWS G+ LWEL TLG+SP +D ++ L
Sbjct: 675 YLKRSKGRVPVKWMAPESLADHVYTSKSDVWSFGVLLWELVTLGASPYPGVDVHNLYNLL 734
Query: 251 NGGYRPSQPHNCPDEL 266
GYR +P NC +L
Sbjct: 735 KAGYRMEKPANCSHQL 750
>UniRef50_P03949 Cluster: Tyrosine-protein kinase abl-1; n=5;
Caenorhabditis|Rep: Tyrosine-protein kinase abl-1 -
Caenorhabditis elegans
Length = 1224
Score = 129 bits (311), Expect = 8e-29
Identities = 80/237 (33%), Positives = 118/237 (49%), Gaps = 14/237 (5%)
Query: 31 RLEILIHE----GTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLV 86
R EI++H G +G +Y+G +K+ D + VK E + L
Sbjct: 308 RSEIIMHNKLGGGQYGDVYEGYWKRHDC--TIAVKALKEDAMPLHEFLA--EAAIMKDLH 363
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVAC 146
H N++ + C EA P I + NL +L R +S LV + +Q+A
Sbjct: 364 HKNLVRLLGVCTHEA--PFYIITEFMCNGNLLEYL---RRTDKSLLPPIILVQMASQIAS 418
Query: 147 GLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAP 206
G+SYL + F+H D+AARNC+V E +K+ D GLAR + D Y P+KW AP
Sbjct: 419 GMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMKEDTYTAHA-GAKFPIKWTAP 477
Query: 207 ETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCP 263
E L N +S+ SDVW+ G+ LWE+AT G +P ++ ++V L G+R P CP
Sbjct: 478 EGLAFNTFSSKSDVWAFGVLLWEIATYGMAPYPGVELSNVYGLLENGFRMDGPQGCP 534
>UniRef50_P00529 Cluster: Tyrosine-protein kinase transforming
protein ros; n=3; root|Rep: Tyrosine-protein kinase
transforming protein ros - Avian sarcoma virus (strain
UR2)
Length = 402
Score = 128 bits (310), Expect = 1e-28
Identities = 76/252 (30%), Positives = 118/252 (46%), Gaps = 14/252 (5%)
Query: 27 RSNIRLEILIHEGTFGRIYKG----VFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRL 82
R + L L+ G FG +Y+G + G V VKT E +
Sbjct: 95 RDKLNLHKLLGSGAFGEVYEGTALDILADGSGESRVAVKTLKRGATDQEKSEFLKEAHLM 154
Query: 83 YGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAP--ATRELVDL 140
H ++L + C + L++ +L +L R + +P +L+D+
Sbjct: 155 SKFDHPHILKLLGVCLLNEPQYLILELM--EGGDLLSYLRGARKQKFQSPLLTLTDLLDI 212
Query: 141 GAQVACGLSYLHVQRFVHADVAARNCVVDEKLR------LKVTDNGLARDLFPDDYHCLG 194
+ G YL RF+H D+AARNC+V EK +K+ D GLARD++ +DY+
Sbjct: 213 CLDICKGCVYLEKMRFIHRDLAARNCLVSEKQYGSCSRVVKIGDFGLARDIYKNDYYRKR 272
Query: 195 DNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGY 254
PV+WMAPE+L+ ++ SDVW+ G+ +WE TLG P L +V + G
Sbjct: 273 GEGLLPVRWMAPESLIDGVFTNHSDVWAFGVLVWETLTLGQQPYPGLSNIEVLHHVRSGG 332
Query: 255 RPSQPHNCPDEL 266
R P+NCPD++
Sbjct: 333 RLESPNNCPDDI 344
>UniRef50_UPI00004D7E5F Cluster: Proto-oncogene tyrosine-protein
kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor
tyrosine kinase MerTK).; n=1; Xenopus tropicalis|Rep:
Proto-oncogene tyrosine-protein kinase MER precursor (EC
2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK). -
Xenopus tropicalis
Length = 763
Score = 128 bits (309), Expect = 1e-28
Identities = 80/260 (30%), Positives = 129/260 (49%), Gaps = 10/260 (3%)
Query: 15 DPAEQLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKKGD-VYEEVMVKTXXXXXXXXXXX 73
D ++L + R+ + L ++ EG FG + +G + D +V VKT
Sbjct: 456 DLQQKLEDVMVERNLLNLGKVLGEGEFGSVMEGELQYSDGTNHKVAVKTMKMDNFSQREI 515
Query: 74 XXX-XEGLRLYGLVHANVLTPMAACAE----EARKPLLIYCCPSHSSNLKRFLSSCRLGQ 128
E + H NV+ + C E KP++I + +L FL S R+G
Sbjct: 516 EEFLSEAACMKDFNHPNVIRLLGVCLEVGPRRIPKPMVILPFMKYG-DLHSFLLSSRIGS 574
Query: 129 --QSAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLF 186
Q P R LV +A G+ YL + F+H D+AARNC++ + + + V D GL++ ++
Sbjct: 575 GPQHVPL-RTLVKFMIDIATGMEYLSSRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIY 633
Query: 187 PDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADV 246
DY+ G PVKW+A E+L Y+ SDVW+ G+T+WE++T G +P + ++
Sbjct: 634 SGDYYRQGRIAKMPVKWIAVESLADRIYTVKSDVWAFGVTMWEISTRGMTPYPGVQNHEI 693
Query: 247 GAFLNGGYRPSQPHNCPDEL 266
+L G+R QP C D+L
Sbjct: 694 YDYLLVGHRLKQPPECLDDL 713
>UniRef50_Q8WRF4 Cluster: Receptor tyrosine kinase; n=1; Monosiga
brevicollis|Rep: Receptor tyrosine kinase - Monosiga
brevicollis
Length = 1476
Score = 128 bits (309), Expect = 1e-28
Identities = 66/181 (36%), Positives = 100/181 (55%), Gaps = 6/181 (3%)
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATR--ELVDLGAQV 144
H NV+ + C E + LL+ + N++ +L CR Q++ R ++ D Q+
Sbjct: 786 HPNVIGIIGHCLRETPQILLVEL--AEFGNMRDYLRGCRATQENPQTIRVDQMADFCLQI 843
Query: 145 ACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWM 204
A G+++L + +H D+AARN +VD+ K++D GLAR + +Y PVKWM
Sbjct: 844 ARGMAFLEQKNVIHRDLAARNVLVDKNFECKISDFGLARSIEGGEYKTTATK--LPVKWM 901
Query: 205 APETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPD 264
APE+L Y+T SDVWS G+T+WE+ +LG +P E DV +FL G+R P P
Sbjct: 902 APESLKSRIYTTKSDVWSFGVTMWEIFSLGGTPYKEHQNRDVLSFLESGHRLPSPRQAPV 961
Query: 265 E 265
E
Sbjct: 962 E 962
>UniRef50_A7RHT9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 295
Score = 128 bits (309), Expect = 1e-28
Identities = 84/257 (32%), Positives = 129/257 (50%), Gaps = 20/257 (7%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFK--KGDVYE-EVMVKTXXXXXXXXXXXXXXXEGLRLY 83
R ++ +++ G FG + K + KG V V VK E L L
Sbjct: 6 RDRVKTSVVLGSGAFGVVMKADAQGIKGCVGSLPVAVKIVKENDSDTARRDLMAE-LDLL 64
Query: 84 GLV--HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCR-----------LGQQS 130
L+ H NV+ + C PL++ +L+ +L CR + +
Sbjct: 65 KLIDPHPNVIGLLGCCTRG--DPLMVIVEFCQYGDLQSYLRHCRGIEDKYYEQIYMVPEK 122
Query: 131 APATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDY 190
++L+ G Q A G+++L + VH D+AARN ++DEK KV+D G ARD++ +D+
Sbjct: 123 KLTAKDLLSFGIQAARGMAHLASMKVVHRDLAARNILIDEKSVCKVSDFGFARDIYVEDH 182
Query: 191 HCLGDNENR-PVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAF 249
+ R P+KWMA E+LL +T SDVWS G+ LWE+ TLG+SP +++ +V F
Sbjct: 183 YTRKTQGGRFPIKWMAIESLLDGVSTTKSDVWSYGVLLWEIVTLGASPYPGMNSQEVINF 242
Query: 250 LNGGYRPSQPHNCPDEL 266
L GYR +P +C DEL
Sbjct: 243 LQDGYRMDKPKHCLDEL 259
>UniRef50_Q4RWP2 Cluster: Tyrosine-protein kinase receptor; n=1;
Tetraodon nigroviridis|Rep: Tyrosine-protein kinase
receptor - Tetraodon nigroviridis (Green puffer)
Length = 1419
Score = 127 bits (307), Expect = 3e-28
Identities = 56/136 (41%), Positives = 85/136 (62%), Gaps = 2/136 (1%)
Query: 132 PATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYH 191
P +E++ + A++A G++YL+ ++FVH D+AARNC+V +K+ D G+ RD++ DY+
Sbjct: 1167 PTLKEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVGHDFTVKIGDFGMTRDIYETDYY 1226
Query: 192 CLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAF-L 250
G PV+WMAPE+L ++ SD WS G+ LWE++TL P L V F +
Sbjct: 1227 RKGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEISTLSEQPYQGLSNEQVLKFVM 1286
Query: 251 NGGYRPSQPHNCPDEL 266
+GGY +P NCPD L
Sbjct: 1287 DGGYL-DRPDNCPDRL 1301
>UniRef50_Q16620 Cluster: BDNF/NT-3 growth factors receptor
precursor; n=73; Gnathostomata|Rep: BDNF/NT-3 growth
factors receptor precursor - Homo sapiens (Human)
Length = 822
Score = 127 bits (306), Expect = 3e-28
Identities = 74/250 (29%), Positives = 125/250 (50%), Gaps = 12/250 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKG-VFKKGDVYEEVMVKTXXXXXXXXXXXXXXX-EGLRLYG 84
R NI L+ + EG FG+++ + ++++V E L
Sbjct: 535 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTN 594
Query: 85 LVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSS----CRLGQQSAPATR----E 136
L H +++ C E PL++ +L +FL + L + P T +
Sbjct: 595 LQHEHIVKFYGVCVEG--DPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQ 652
Query: 137 LVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDN 196
++ + Q+A G+ YL Q FVH D+A RNC+V E L +K+ D G++RD++ DY+ +G +
Sbjct: 653 MLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGH 712
Query: 197 ENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRP 256
P++WM PE+++ +++T SDVWSLG+ LWE+ T G P +L +V + G
Sbjct: 713 TMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVL 772
Query: 257 SQPHNCPDEL 266
+P CP E+
Sbjct: 773 QRPRTCPQEV 782
>UniRef50_Q91987 Cluster: BDNF/NT-3 growth factors receptor
precursor; n=17; Euteleostomi|Rep: BDNF/NT-3 growth
factors receptor precursor - Gallus gallus (Chicken)
Length = 818
Score = 127 bits (306), Expect = 3e-28
Identities = 74/250 (29%), Positives = 126/250 (50%), Gaps = 12/250 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKG-VFKKGDVYEEVMVKTXXXXXXXXXXXXXXX-EGLRLYG 84
R NI L+ + EG FG+++ + ++++V E L
Sbjct: 531 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTN 590
Query: 85 LVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSS-------CRLGQQSAPATR-E 136
L H +++ C E PL++ +L +FL + G + A T+ +
Sbjct: 591 LQHEHIVKFYGVCVEG--DPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNRPAELTQSQ 648
Query: 137 LVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDN 196
++ + Q+A G+ YL Q FVH D+A RNC+V E L +K+ D G++RD++ DY+ +G +
Sbjct: 649 MLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGH 708
Query: 197 ENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRP 256
P++WM PE+++ +++T SDVWSLG+ LWE+ T G P +L +V + G
Sbjct: 709 TMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVL 768
Query: 257 SQPHNCPDEL 266
+P CP E+
Sbjct: 769 QRPRTCPKEV 778
>UniRef50_Q170Z1 Cluster: Tyrosine-protein kinase receptor; n=1; Aedes
aegypti|Rep: Tyrosine-protein kinase receptor - Aedes
aegypti (Yellowfever mosquito)
Length = 2073
Score = 126 bits (305), Expect = 4e-28
Identities = 74/236 (31%), Positives = 117/236 (49%), Gaps = 10/236 (4%)
Query: 39 GTFGRIYKGVFKK--GDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMAA 96
G FG +Y+G+ K G+ V +KT E + H ++L +
Sbjct: 1821 GAFGEVYEGIVKGVGGEAETRVAIKTLRKGATEQEKAEFLQEAHLMSNFKHKHILKLIGV 1880
Query: 97 CAEEARKPLLIYCCPSHSSNLKRFLSSCRL--GQQSAPATRELVDLGAQVACGLSYLHVQ 154
C + L I +L +L S R G S +L+ + VA G YL
Sbjct: 1881 CLD--LDSLYIVMELMQGGDLLSYLRSNRPTPGNPSMLTLLDLISMCVDVATGCRYLEEM 1938
Query: 155 RFVHADVAARNCVV---DEKLRL-KVTDNGLARDLFPDDYHCLGDNENRPVKWMAPETLL 210
FVH D+A RNC+V D + R+ K+ D GLARD++ +DY+ PV+WM+PE+L+
Sbjct: 1939 HFVHRDLACRNCLVSSMDPRERVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMSPESLV 1998
Query: 211 QNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
+++ SD+W+ G+ LWE+ TLG P + +V ++ G R ++P +CP+EL
Sbjct: 1999 DGVFTSQSDIWAFGVLLWEIMTLGQQPYPARNNVEVLHYVRDGGRLTRPQDCPEEL 2054
>UniRef50_Q06418 Cluster: Tyrosine-protein kinase receptor TYRO3
precursor; n=30; Tetrapoda|Rep: Tyrosine-protein kinase
receptor TYRO3 precursor - Homo sapiens (Human)
Length = 890
Score = 126 bits (305), Expect = 4e-28
Identities = 60/164 (36%), Positives = 97/164 (59%), Gaps = 2/164 (1%)
Query: 104 PLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRE-LVDLGAQVACGLSYLHVQRFVHADVA 162
P++I H +L FL + R+G+ + L+ +ACG+ YL + F+H D+A
Sbjct: 599 PMVILPFMKHG-DLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLA 657
Query: 163 ARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWS 222
ARNC++ E + + V D GL+R ++ DY+ G PVKW+A E+L N Y+ SDVW+
Sbjct: 658 ARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWA 717
Query: 223 LGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
G+T+WE+ T G +P A ++ A++ +L GG R QP C +++
Sbjct: 718 FGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDV 761
>UniRef50_UPI0000EB1EAB Cluster: Serine/threonine-protein kinase
LMTK1 (EC 2.7.11.1) (Lemur tyrosine kinase 1)
(Apoptosis-associated tyrosine kinase) (AATYK) (Brain
apoptosis-associated tyrosine kinase) (CDK5-binding
protein) (p35- binding protein) (p35BP).; n=3;
Amniota|Rep: Serine/threonine-protein kinase LMTK1 (EC
2.7.11.1) (Lemur tyrosine kinase 1)
(Apoptosis-associated tyrosine kinase) (AATYK) (Brain
apoptosis-associated tyrosine kinase) (CDK5-binding
protein) (p35- binding protein) (p35BP). - Canis
familiaris
Length = 747
Score = 126 bits (303), Expect = 8e-28
Identities = 71/210 (33%), Positives = 108/210 (51%), Gaps = 10/210 (4%)
Query: 36 IHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRL-YGLVHANVLTPM 94
+ G FG+++ G G +V+VK E L H+N+L +
Sbjct: 114 VGHGWFGKVFLGEVNSGISSTQVVVKELKASASVQEQMQFLEEAQPYSLALQHSNLLQCL 173
Query: 95 AACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQ 154
A CAE L++ CP +LK +L SCR+ + AP L + +VACG+ +LH
Sbjct: 174 AQCAEVTPYLLVMEFCPM--GDLKGYLRSCRVAESMAPDPLTLQRMACEVACGVLHLHRN 231
Query: 155 RFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPE------- 207
+VH+D+A RNC++ L +K+ D GL+ + +DY D P++W+APE
Sbjct: 232 NYVHSDLALRNCLLAADLTVKIGDYGLSHGKYREDYFVTADQLWVPLRWIAPELVDEVHC 291
Query: 208 TLLQNQYSTASDVWSLGITLWELATLGSSP 237
LL + AS+VWSLG+T+WEL LG+ P
Sbjct: 292 NLLVVDQTKASNVWSLGVTIWELFELGAQP 321
>UniRef50_Q4SQ93 Cluster: Tyrosine-protein kinase receptor; n=2;
Tetraodontidae|Rep: Tyrosine-protein kinase receptor -
Tetraodon nigroviridis (Green puffer)
Length = 822
Score = 126 bits (303), Expect = 8e-28
Identities = 66/192 (34%), Positives = 105/192 (54%), Gaps = 12/192 (6%)
Query: 85 LVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRL-------GQQSAPAT--- 134
L H +++T C E PL++ +L +FL S GQ S P
Sbjct: 593 LQHEHIVTFYGVCVES--DPLIMVFEYMKHGDLNKFLRSHGPDAVLIVDGQHSIPVELTQ 650
Query: 135 RELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLG 194
+++ + Q+A G+ YL Q FVH D+A RNC+V E L +K+ D G++RD++ DY+ +G
Sbjct: 651 SQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVG 710
Query: 195 DNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGY 254
+ P++WM PE+++ +++T SDVWSLG+ LWE+ T G P +L +V + G
Sbjct: 711 GHTMLPIRWMPPESIMYRRFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGR 770
Query: 255 RPSQPHNCPDEL 266
+P CP E+
Sbjct: 771 VLQRPRTCPKEV 782
>UniRef50_Q3TJ05 Cluster: 14 days pregnant adult female placenta
cDNA, RIKEN full-length enriched library,
clone:I530025O09 product:fibroblast growth factor
receptor 1, full insert sequence; n=18; Eumetazoa|Rep:
14 days pregnant adult female placenta cDNA, RIKEN
full-length enriched library, clone:I530025O09
product:fibroblast growth factor receptor 1, full insert
sequence - Mus musculus (Mouse)
Length = 386
Score = 126 bits (303), Expect = 8e-28
Identities = 68/191 (35%), Positives = 102/191 (53%), Gaps = 13/191 (6%)
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRL-----------GQQSAPATR 135
H N++ + AC ++ PL + + NL+ +L + R + +++
Sbjct: 105 HKNIINLLGACTQDG--PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSK 162
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGD 195
+LV QVA G+ YL ++ +H D+AARN +V E +K+ D GLARD+ DY+
Sbjct: 163 DLVSCAYQVARGMEYLASKKCIHRDLAARNALVTEDNVMKIADFGLARDIHHIDYYKKTT 222
Query: 196 NENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYR 255
N PVKWMAPE L Y+ SDVWS G+ LWE+ TLG SP + ++ L G+R
Sbjct: 223 NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHR 282
Query: 256 PSQPHNCPDEL 266
+P NC +EL
Sbjct: 283 MDKPSNCTNEL 293
>UniRef50_Q9XVQ7 Cluster: Putative uncharacterized protein; n=2;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 442
Score = 126 bits (303), Expect = 8e-28
Identities = 85/259 (32%), Positives = 128/259 (49%), Gaps = 14/259 (5%)
Query: 14 TDPAEQLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKK-GDVYEEVMVKTXXXXXXXXXX 72
+D + L+ L + LE ++ +G FG +Y+G + V VKT
Sbjct: 120 SDLRQSLQGLLLPSEAVVLETIVGKGYFGNVYRGRMRDPAGRLIPVAVKTLKGERARDIA 179
Query: 73 XXXXX--EGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQS 130
EG+ + L H +VL+ + A P ++ +LK +++
Sbjct: 180 HIEKFLREGVVMKHLDHPHVLSLLGISISPAGNPWVVLPY-MEGGDLKTYIAD----PNR 234
Query: 131 APATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDY 190
A EL+D QVA G+SYL Q FVH D+AARNC++ +KV D GLA DL D
Sbjct: 235 ALCVLELLDFAHQVAQGMSYLAAQHFVHRDLAARNCMISADRIVKVADFGLAVDLL-DKE 293
Query: 191 HCLGDNE----NRPVKWMAPETLLQNQ-YSTASDVWSLGITLWELATLGSSPLAELDAAD 245
+ ++E P+KW+APE+L + +S+A+DVWS G+ +WEL T +SP E+
Sbjct: 294 SYIDESETGPARLPLKWLAPESLRDRRVFSSATDVWSFGVLMWELLTRAASPYGEVSNTK 353
Query: 246 VGAFLNGGYRPSQPHNCPD 264
V +L G R QP +CPD
Sbjct: 354 VRHYLETGMRLPQPTHCPD 372
>UniRef50_Q9U5A8 Cluster: Insulin receptor-like protein precursor;
n=1; Bombyx mori|Rep: Insulin receptor-like protein
precursor - Bombyx mori (Silk moth)
Length = 1472
Score = 126 bits (303), Expect = 8e-28
Identities = 74/252 (29%), Positives = 122/252 (48%), Gaps = 13/252 (5%)
Query: 26 SRSNIRLEILIHEGTFGRIYKGVFK---KGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRL 82
+R +I + +G+FG +Y+G+ K KG +KT E +
Sbjct: 1078 TRDSIHFIRELGQGSFGMVYEGIAKEIVKGKPETRCAIKTVNEHATDRERIEFLNEASVM 1137
Query: 83 YGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSA--------PAT 134
+V+ + + +P L+ +LK +L S R + + P
Sbjct: 1138 KAFDTFHVVRLLGVVSRG--QPTLVVMELMERGDLKTYLRSMRPDAEGSLPSSPPVPPTL 1195
Query: 135 RELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLG 194
+ ++ + ++A G++YL ++FVH D+AARNC+V L +KV D G+ RD++ DY+ G
Sbjct: 1196 QNILQMAIEIADGMAYLSAKKFVHRDLAARNCMVAGDLTVKVGDFGMTRDIYETDYYRKG 1255
Query: 195 DNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGY 254
PV+WM+PE+L +S++SD WS G+ LWE+ATL P L V ++ G
Sbjct: 1256 TKGLMPVRWMSPESLKDGVFSSSSDAWSYGVVLWEMATLAMQPYQGLSNEQVLRYVVEGG 1315
Query: 255 RPSQPHNCPDEL 266
+P CPD L
Sbjct: 1316 VMERPEQCPDRL 1327
>UniRef50_Q8JG38 Cluster: Fibroblast growth factor receptor 2
precursor; n=11; Eumetazoa|Rep: Fibroblast growth factor
receptor 2 precursor - Danio rerio (Zebrafish)
(Brachydanio rerio)
Length = 817
Score = 126 bits (303), Expect = 8e-28
Identities = 71/191 (37%), Positives = 104/191 (54%), Gaps = 13/191 (6%)
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRL-GQQSA---------PAT-R 135
H N++ + AC ++ PL + + NL+ +L + R G + + P T +
Sbjct: 540 HKNIINLLGACTQDG--PLYVIVEYASKGNLREYLRARRPPGMEYSYDIARVSDEPLTFK 597
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGD 195
+LV QVA G+ YL Q+ +H D+AARN +V E +K+ D GLARD+ DY+
Sbjct: 598 DLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNVMKIADFGLARDVHNIDYYKKTT 657
Query: 196 NENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYR 255
N PVKWMAPE L Y+ SDVWS G+ +WE+ TLG SP + ++ L G+R
Sbjct: 658 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHR 717
Query: 256 PSQPHNCPDEL 266
+P NC +EL
Sbjct: 718 MDKPANCTNEL 728
>UniRef50_UPI0000E47617 Cluster: PREDICTED: similar to muscle
specific tyrosine kinase receptor; n=1;
Strongylocentrotus purpuratus|Rep: PREDICTED: similar to
muscle specific tyrosine kinase receptor -
Strongylocentrotus purpuratus
Length = 827
Score = 125 bits (302), Expect = 1e-27
Identities = 80/258 (31%), Positives = 118/258 (45%), Gaps = 10/258 (3%)
Query: 19 QLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKK---GDVYEEVMVKTXXXXXXXXXXXXX 75
QL L +R+N+ E I EG FGR++ K G+ V VK
Sbjct: 528 QLAYLEYNRNNVIYEKDIGEGAFGRVFMASAPKLVAGEAETSVAVKMLKATADKVVTEYF 587
Query: 76 XXEGLRLYGLVHANVLTPMAACAEEARKPLLI-YCCPS------HSSNLKRFLSSCRLGQ 128
E + H N++ + C LL+ Y HS + R S
Sbjct: 588 NREAQMIARFSHQNIVKLLGVCFVGRPLCLLLEYMSEGDLEDYLHSRSPHRSNSRTSNSP 647
Query: 129 QSAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPD 188
S T E +++ Q+ACG++YL+ FVH D+A RNC+++ + +K++D GLAR +
Sbjct: 648 GSGLKTYEKLNMAKQIACGMAYLNEMMFVHRDIATRNCLINSRTDVKISDFGLARYVGHK 707
Query: 189 DYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGA 248
+ E+ P++W APE L Q++ ASDVWS G+ LWEL + P L DV
Sbjct: 708 ECFVGHKEEHIPIRWTAPEALWDYQFTYASDVWSFGVLLWELFSYAEQPYLNLSHEDVFL 767
Query: 249 FLNGGYRPSQPHNCPDEL 266
GYR S N P ++
Sbjct: 768 HTRQGYRLSSLENTPQKV 785
>UniRef50_UPI0000E47068 Cluster: PREDICTED: similar to tyrosine
protein kinase; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to tyrosine protein kinase -
Strongylocentrotus purpuratus
Length = 1566
Score = 125 bits (302), Expect = 1e-27
Identities = 79/249 (31%), Positives = 116/249 (46%), Gaps = 11/249 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGD-VYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGL 85
R N+ L + EG FG +Y G D + V VKT E +
Sbjct: 1017 RENVVLNRKLGEGAFGTVYGGEALLDDNKWAAVAVKTLKLGASVEEKLDFLSEAEVMKRF 1076
Query: 86 VHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCR--LGQ------QSAPATREL 137
H N++ + C +P+ +LK FL R +G+ Q +L
Sbjct: 1077 NHKNIVNLLGVCTRG--EPMYAVMEFMLYGDLKTFLLGRRHLVGEGVYERNQHVMCPDQL 1134
Query: 138 VDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNE 197
+ + +A GLSYL +VH D+A RNC+VD +K+ D G+ R L+ DY+ LG
Sbjct: 1135 TSMVSDIASGLSYLASINYVHRDLACRNCLVDASYTVKIGDFGMTRALYDSDYYRLGKRS 1194
Query: 198 NRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPS 257
PV+WMAPE+L + ++T SDVWSLG+ ++E+ T GS P EL A+V ++
Sbjct: 1195 KLPVRWMAPESLTEGIFTTMSDVWSLGVVIYEVVTFGSFPYQELSNAEVLDYIRNRNSLR 1254
Query: 258 QPHNCPDEL 266
P C L
Sbjct: 1255 PPEGCSPAL 1263
>UniRef50_UPI0000DB7F8D Cluster: PREDICTED: similar to Cad96Ca
CG10244-PA; n=3; Endopterygota|Rep: PREDICTED: similar
to Cad96Ca CG10244-PA - Apis mellifera
Length = 657
Score = 125 bits (302), Expect = 1e-27
Identities = 80/249 (32%), Positives = 123/249 (49%), Gaps = 13/249 (5%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVF-----KKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLR 81
R +++ ++ EG FG+++K K G + V VKT E
Sbjct: 356 RHRLKVFNILGEGCFGQVWKCEALDIDGKSGAII--VAVKTLKENATERERLDLAQELRV 413
Query: 82 LYGL-VHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQ-SAPA--TREL 137
+ L H NV+ + C E R+P+ + L+ FL + R + P +R+L
Sbjct: 414 MKNLDPHPNVVRLLGCCTE--REPMFVILEYVSGGKLQSFLRASREERNHGGPGLTSRDL 471
Query: 138 VDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNE 197
Q+A G+ YL + +H D+AARN ++DE KV D G ARD+ + +
Sbjct: 472 TGFVYQIAKGMEYLASKGIIHRDLAARNILIDENRACKVADFGFARDVAANQIYERKSEG 531
Query: 198 NRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPS 257
P++WMAPE+L N +S SD+WS G+ +WE+ TLGS+P L AA+V + GYR
Sbjct: 532 RLPIRWMAPESLYDNIFSVKSDIWSFGVLIWEIVTLGSTPYPGLAAAEVMRRIKEGYRLD 591
Query: 258 QPHNCPDEL 266
+P +C EL
Sbjct: 592 RPEHCKREL 600
>UniRef50_A3EXK5 Cluster: Fibroblast growth factor receptor b; n=1;
Nematostella vectensis|Rep: Fibroblast growth factor
receptor b - Nematostella vectensis
Length = 591
Score = 125 bits (302), Expect = 1e-27
Identities = 83/255 (32%), Positives = 123/255 (48%), Gaps = 18/255 (7%)
Query: 27 RSNIRLEILIHEGTFGRIYKG--VFKKGDVYE-EVMVK--TXXXXXXXXXXXXXXXEGLR 81
RS I L ++ EG FGR+ K + Y V VK E ++
Sbjct: 271 RSQISLLGILGEGAFGRVVKADAIGLPNMPYRCNVAVKMLXEDATEHELADLVSEMEVMK 330
Query: 82 LYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCR-LGQQSAPATR----- 135
G H N++ + AC ++ PL + + NL++FL + R + + + P T
Sbjct: 331 TIGQ-HVNIINLIGACTQKG--PLFVVVEYASQGNLRQFLRARRPIPEYANPLTEPPREK 387
Query: 136 ----ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYH 191
+LV QVA G+ YL ++ +H D+AARN +V + +K+ D GLARD+ DY+
Sbjct: 388 LKLVDLVSFSYQVARGMEYLESKKCIHRDLAARNVLVSDNHVIKIADFGLARDIHDIDYY 447
Query: 192 CLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLN 251
+ PVKWMA E L Y+ SDVW+ GI +WE+ T G SP + + L
Sbjct: 448 RKTTDGRLPVKWMALEALFDRVYTAQSDVWAYGILMWEIVTFGGSPYPGIPLWKLFELLK 507
Query: 252 GGYRPSQPHNCPDEL 266
GYR QP NC D++
Sbjct: 508 EGYRMEQPVNCQDDV 522
>UniRef50_Q59F30 Cluster: Fibroblast growth factor receptor 4
variant; n=28; Eumetazoa|Rep: Fibroblast growth factor
receptor 4 variant - Homo sapiens (Human)
Length = 1034
Score = 125 bits (302), Expect = 1e-27
Identities = 73/200 (36%), Positives = 104/200 (52%), Gaps = 14/200 (7%)
Query: 78 EGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLG----QQSAPA 133
E ++L G H N++ + C +E +++ C NL+ FL + R P
Sbjct: 754 EVMKLIGR-HKNIINLLGVCTQEGPLYVIVECAAK--GNLREFLRARRPPGPDLSPDGPR 810
Query: 134 TRE-------LVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLF 186
+ E LV QVA G+ YL ++ +H D+AARN +V E +K+ D GLAR +
Sbjct: 811 SSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVH 870
Query: 187 PDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADV 246
DY+ N PVKWMAPE L Y+ SDVWS GI LWE+ TLG SP + ++
Sbjct: 871 HIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEEL 930
Query: 247 GAFLNGGYRPSQPHNCPDEL 266
+ L G+R +P +CP EL
Sbjct: 931 FSLLREGHRMDRPPHCPPEL 950
>UniRef50_P11362 Cluster: Basic fibroblast growth factor receptor 1
precursor; n=310; Euteleostomi|Rep: Basic fibroblast
growth factor receptor 1 precursor - Homo sapiens
(Human)
Length = 822
Score = 125 bits (302), Expect = 1e-27
Identities = 68/191 (35%), Positives = 102/191 (53%), Gaps = 13/191 (6%)
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRL-----------GQQSAPATR 135
H N++ + AC ++ PL + + NL+ +L + R + +++
Sbjct: 541 HKNIINLLGACTQDG--PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSK 598
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGD 195
+LV QVA G+ YL ++ +H D+AARN +V E +K+ D GLARD+ DY+
Sbjct: 599 DLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTT 658
Query: 196 NENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYR 255
N PVKWMAPE L Y+ SDVWS G+ LWE+ TLG SP + ++ L G+R
Sbjct: 659 NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHR 718
Query: 256 PSQPHNCPDEL 266
+P NC +EL
Sbjct: 719 MDKPSNCTNEL 729
>UniRef50_A7SL46 Cluster: Predicted protein; n=2; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 252
Score = 125 bits (301), Expect = 1e-27
Identities = 55/132 (41%), Positives = 80/132 (60%)
Query: 135 RELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLG 194
++L+ Q+A G+ YL + FVH D+AARN +V + ++KV D GL RDL+ + +
Sbjct: 81 QDLLSFSYQIAAGMEYLSKKGFVHRDLAARNVLVADNKQVKVADFGLTRDLYEESAYQGH 140
Query: 195 DNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGY 254
N P+KWM+PE + ++T SDVWS G+ LWE+ATLG +P + DV L GY
Sbjct: 141 SNRKLPIKWMSPEAIYDQIFTTESDVWSYGVVLWEIATLGGAPYPTISTRDVFVMLRSGY 200
Query: 255 RPSQPHNCPDEL 266
R +P C DE+
Sbjct: 201 RMEKPDICSDEV 212
>UniRef50_Q93105 Cluster: Insulin-like receptor precursor (EC
2.7.10.1) (MIR) [Contains: Insulin-like receptor alpha
chain; Insulin-like receptor beta chain]; n=2; Aedes
aegypti|Rep: Insulin-like receptor precursor (EC
2.7.10.1) (MIR) [Contains: Insulin-like receptor alpha
chain; Insulin-like receptor beta chain] - Aedes aegypti
(Yellowfever mosquito)
Length = 1390
Score = 124 bits (300), Expect = 2e-27
Identities = 75/246 (30%), Positives = 125/246 (50%), Gaps = 12/246 (4%)
Query: 30 IRLEILIHEGTFGRIYKGVFK--KGDVYEE-VMVKTXXXXXXXXXXXXXXXEGLRLYGLV 86
I+LE L +G+FG +YKG+ +G+ + +KT E +
Sbjct: 1026 IQLEEL-GQGSFGMVYKGILTQLRGEKCNQPCAIKTVNESATAREKDSFLLEASVMKQFN 1084
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLS------SCRLGQQSAPATRELVDL 140
+V+ + ++ P L+ + +LK +L R + P R+++ +
Sbjct: 1085 THHVVRLLGVVSQG--DPTLVIMELMANGDLKSYLRRHRPDYEMRRSIRQPPTLRQIIQM 1142
Query: 141 GAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRP 200
++A G+ L ++FVH D+AARNC+V + + +K+ D G+ RD++ DY+ G P
Sbjct: 1143 AIEIADGIGVLSAKKFVHRDLAARNCMVADDMTVKIGDFGMTRDIYETDYYRKGTKGFLP 1202
Query: 201 VKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPH 260
V+WMAPE+L +S++SDV+S G+ LWE+ATL S P L V ++ G +P
Sbjct: 1203 VRWMAPESLKDGIFSSSSDVFSYGVVLWEMATLASQPYQGLTNDQVLRYVIDGGVMERPE 1262
Query: 261 NCPDEL 266
NCPD L
Sbjct: 1263 NCPDNL 1268
>UniRef50_Q9Y1Y5 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 557
Score = 124 bits (299), Expect = 2e-27
Identities = 79/236 (33%), Positives = 112/236 (47%), Gaps = 7/236 (2%)
Query: 38 EGTFGRIYKGVFKK-GDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMAA 96
EG+F ++Y+G + G EV VK E + L H NVL +
Sbjct: 294 EGSFSKVYRGTLHQMGTGTTEVAVKAMKSIESDAEMKSFFTECSVMQTLKHPNVLGILGM 353
Query: 97 CAEEARKPLLIYCCPSHSSNLKRFLSSCR---LGQQSAPATRELVDLG---AQVACGLSY 150
C + L+ + NLK +L R L ++ P L L + G+SY
Sbjct: 354 CFDSPDSIPLMVLPFMVNGNLKDYLKKHRGPHLQLETYPENLSLQMLKRICVDITRGMSY 413
Query: 151 LHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPETLL 210
L +RFVH D+AARNC++D L +KV D GL RD++ +Y+ PVKWM PE L
Sbjct: 414 LADRRFVHRDLAARNCLLDSALAVKVGDFGLTRDIYLTNYYRAPTETKLPVKWMPPEMLQ 473
Query: 211 QNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
+DVWS G+T WE+ + GS+P +D + L G R +P CPDE+
Sbjct: 474 DGVSDEKTDVWSFGVTCWEVFSFGSTPYPGVDNHLMLQHLMSGLRLQKPLLCPDEI 529
>UniRef50_P35590 Cluster: Tyrosine-protein kinase receptor Tie-1
precursor; n=37; Deuterostomia|Rep: Tyrosine-protein
kinase receptor Tie-1 precursor - Homo sapiens (Human)
Length = 1138
Score = 124 bits (299), Expect = 2e-27
Identities = 85/272 (31%), Positives = 127/272 (46%), Gaps = 18/272 (6%)
Query: 7 TVTKDRVTDPAEQLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXX 66
T+T+ P E L +I E LI EG FG++ + + KK + +K
Sbjct: 817 TLTRRPKLQP-EPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEY 875
Query: 67 XXXXXXXXXXXEGLRLYGLVH-ANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCR 125
E L L H N++ + AC + I P NL FL R
Sbjct: 876 ASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPY--GNLLDFLRKSR 933
Query: 126 L-----------GQQSAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRL 174
+ G S ++R+L+ + A G+ YL ++F+H D+AARN +V E L
Sbjct: 934 VLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLAS 993
Query: 175 KVTDNGLARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLG 234
K+ D GL+R ++ + PV+WMA E+L + Y+T SDVWS G+ LWE+ +LG
Sbjct: 994 KIADFGLSRG---EEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLG 1050
Query: 235 SSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
+P + A++ L GYR QP NC DE+
Sbjct: 1051 GTPYCGMTCAELYEKLPQGYRMEQPRNCDDEV 1082
>UniRef50_Q03142 Cluster: Fibroblast growth factor receptor 4
precursor; n=9; Eutheria|Rep: Fibroblast growth factor
receptor 4 precursor - Mus musculus (Mouse)
Length = 799
Score = 124 bits (299), Expect = 2e-27
Identities = 73/200 (36%), Positives = 103/200 (51%), Gaps = 14/200 (7%)
Query: 78 EGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLG----QQSAPA 133
E ++L G H N++ + C +E +++ C NL+ FL + R P
Sbjct: 519 EVMKLIGR-HKNIINLLGVCTQEGPLYVIVECAAK--GNLREFLRARRPPGPDLSPDGPR 575
Query: 134 TRE-------LVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLF 186
+ E LV QVA G+ YL ++ +H D+AARN +V E +K+ D GLAR +
Sbjct: 576 SSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVH 635
Query: 187 PDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADV 246
DY+ N PVKWMAPE L Y+ SDVWS I LWE+ TLG SP + ++
Sbjct: 636 HIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFEILLWEIFTLGGSPYPGIPVEEL 695
Query: 247 GAFLNGGYRPSQPHNCPDEL 266
+ L G+R +P NCP EL
Sbjct: 696 FSLLREGHRMERPPNCPSEL 715
>UniRef50_O76148 Cluster: Tyrosine-protein kinase receptor; n=1;
Anopheles sp.|Rep: Tyrosine-protein kinase receptor -
Anopheles sp
Length = 863
Score = 124 bits (298), Expect = 3e-27
Identities = 75/239 (31%), Positives = 117/239 (48%), Gaps = 9/239 (3%)
Query: 35 LIHEGTFGRIYKGVFK--KGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLT 92
L+ G FG +Y+GV K G+ V +KT E + H ++
Sbjct: 456 LLGSGAFGEVYEGVVKGVDGEAETRVAIKTLKKGAKLHEKQEFLQEAQLMSNFKHKHITR 515
Query: 93 PMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATR-ELVDLGAQVACGLSYL 151
+ C E LLI +L +L + L Q+A T +L+ + VA G YL
Sbjct: 516 LLGVCLEA--DALLIIMELMQGGDLLSYLPAQPLPGQAARLTMLDLISMCQDVASGCRYL 573
Query: 152 HVQRFVHADVAARNCVV---DEKLRL-KVTDNGLARDLFPDDYHCLGDNENRPVKWMAPE 207
FVH D+A RNC+V D + R+ K+ D GLARD++ +DY+ PV+WM+PE
Sbjct: 574 EEMHFVHRDLACRNCLVSSTDPRDRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMSPE 633
Query: 208 TLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
+L+ +++ SD+W+ G+ LWE+ TLG P + +V + G +P CP+E+
Sbjct: 634 SLVDGVFTSQSDIWAFGVLLWEIMTLGEQPYQAKNNVEVLNHVREGGHLDRPKVCPNEM 692
>UniRef50_P09208 Cluster: Insulin-like receptor precursor (EC
2.7.10.1) (DIR) (DInr) (dIRH) [Contains: Insulin-like
receptor subunit alpha; Insulin-like receptor subunit
beta 1; Insulin-like receptor subunit beta 2]; n=15;
Eumetazoa|Rep: Insulin-like receptor precursor (EC
2.7.10.1) (DIR) (DInr) (dIRH) [Contains: Insulin-like
receptor subunit alpha; Insulin-like receptor subunit
beta 1; Insulin-like receptor subunit beta 2] -
Drosophila melanogaster (Fruit fly)
Length = 2144
Score = 124 bits (298), Expect = 3e-27
Identities = 78/260 (30%), Positives = 122/260 (46%), Gaps = 22/260 (8%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKK---GDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLY 83
R NI + +G+FG +Y+G+ K V E +KT E +
Sbjct: 1368 RENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMK 1427
Query: 84 GLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCR-----------------L 126
+V+ + C+ +P L+ +LK +L + R
Sbjct: 1428 EFDTYHVVRLLGVCSRG--QPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVT 1485
Query: 127 GQQSAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLF 186
G P + + ++A G++YL ++FVH D+AARNC+V + L +K+ D G+ RD++
Sbjct: 1486 GNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIY 1545
Query: 187 PDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADV 246
DY+ G PV+WM PE+L YS+ASDV+S G+ LWE+ATL + P L V
Sbjct: 1546 ETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQV 1605
Query: 247 GAFLNGGYRPSQPHNCPDEL 266
++ G +P NCPD L
Sbjct: 1606 LRYVIDGGVMERPENCPDFL 1625
>UniRef50_Q86PM4 Cluster: Fibroblast growth factor receptor
precursor; n=1; Hydra vulgaris|Rep: Fibroblast growth
factor receptor precursor - Hydra attenuata (Hydra)
(Hydra vulgaris)
Length = 816
Score = 124 bits (298), Expect = 3e-27
Identities = 81/263 (30%), Positives = 133/263 (50%), Gaps = 19/263 (7%)
Query: 15 DPAEQLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVY---EEVMVKTXXXX--XXX 69
DPA ++++ + + L+ EG FGR+++ + + + V VK
Sbjct: 464 DPAWEIKL-----EQLETDCLLGEGAFGRVFRATARDLPNHTGVQTVAVKMLKEDCCEQD 518
Query: 70 XXXXXXXXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCR-LGQ 128
E ++ G H N+L +A +++ + +++ C NL+ FL R + Q
Sbjct: 519 LKDFISEIEVMKSIGK-HINILNLLAVSSQQGKLYIVVEYC--RHGNLRSFLKDNRPVMQ 575
Query: 129 QSAPATRE--LVDLGA---QVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLAR 183
++ T++ L DL + QVA G+++L ++ +H D+AARN +V E +K+ D GLAR
Sbjct: 576 ANSVITKKITLYDLTSFCLQVARGMNFLASKKCIHRDIAARNVLVGEGYLMKIADFGLAR 635
Query: 184 DLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDA 243
D+ DY+ + PVKWMA E L Y+T SD+WS GI WE+ T G SP +
Sbjct: 636 DIHEQDYYRKCTDGRLPVKWMAIEALFDRVYTTQSDIWSFGILAWEIVTFGGSPYPGIAL 695
Query: 244 ADVGAFLNGGYRPSQPHNCPDEL 266
+ L GYR +P NC D++
Sbjct: 696 EKLFDLLKQGYRMERPLNCTDDM 718
>UniRef50_Q7YZH7 Cluster: MBRTK2; n=1; Monosiga brevicollis|Rep:
MBRTK2 - Monosiga brevicollis
Length = 759
Score = 123 bits (297), Expect = 4e-27
Identities = 74/244 (30%), Positives = 117/244 (47%), Gaps = 9/244 (3%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEE--VMVKTXXXXXXXXXXXXXXXEGLRLYG 84
R ++RL + G FG++++ F EE K E +
Sbjct: 357 RRSVRLGEKLGNGAFGQVFRAWFCNRHSGEERSCAAKALKPGAPFRARQDFLSEMTVMKE 416
Query: 85 L-VHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAP--ATRELVDLG 141
+ H N++ C + LL+ + NL+ +L CR Q +R+L D
Sbjct: 417 IGAHPNIIGIFGHCLRDEPHILLVEL--AELGNLRDYLRKCRTSQSKPQLLGSRQLADFC 474
Query: 142 AQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPV 201
Q+A G+S+L + +H D+AARN ++ + L K+ D GLAR + +DY PV
Sbjct: 475 LQIASGMSFLERKNVIHRDLAARNVLLSQSLACKICDFGLARSIENEDYETTATK--LPV 532
Query: 202 KWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHN 261
KWMAPE+L Y++ SDVWS G+T+WE+ +LG +P + D+ + L GYR +P
Sbjct: 533 KWMAPESLGYRIYTSKSDVWSFGVTMWEIFSLGGTPYVKHRNVDILSLLADGYRLPKPRQ 592
Query: 262 CPDE 265
P +
Sbjct: 593 APGQ 596
>UniRef50_Q7YXV8 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 865
Score = 123 bits (297), Expect = 4e-27
Identities = 76/235 (32%), Positives = 114/235 (48%), Gaps = 8/235 (3%)
Query: 36 IHEGTFGRIYKGVFKKGDV-YEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPM 94
I EG FG++YKG+ + + E V +KT E + H N++
Sbjct: 595 IGEGAFGKVYKGLLTQAESSVEHVAIKTIKIFAGIESIRSFFTECASMTSFRHPNIIELF 654
Query: 95 AACAEEARKPLLIYCCPSHSSNLKRFLSSCR--LGQQSAPATREL-----VDLGAQVACG 147
C + L+ + NLK +L R L ++ EL + +A G
Sbjct: 655 GMCFDAPDGTPLMVLPFMINGNLKSYLVKSRNPLSEKPDIFPNELGLAVMTKMCTDIARG 714
Query: 148 LSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPE 207
+SY QRFVH D+AARNC++D L +K+ D GLAR+++ Y+ PVKWMAPE
Sbjct: 715 MSYFVDQRFVHRDLAARNCLLDHDLTVKIGDFGLARNVYMTGYYKASTRAALPVKWMAPE 774
Query: 208 TLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNC 262
L + +DVW+ G+T WE+ +LGS+P +D V L G+R ++P C
Sbjct: 775 MLRDGISNEKTDVWAYGVTCWEVFSLGSTPYPGVDNHLVLEHLMKGFRLAKPFLC 829
>UniRef50_Q24488 Cluster: Tyrosine-protein kinase transmembrane
receptor Ror precursor; n=1; Drosophila
melanogaster|Rep: Tyrosine-protein kinase transmembrane
receptor Ror precursor - Drosophila melanogaster (Fruit
fly)
Length = 685
Score = 123 bits (297), Expect = 4e-27
Identities = 70/263 (26%), Positives = 123/263 (46%), Gaps = 3/263 (1%)
Query: 2 NASGQTVTKDRVTDPAEQLRVLTTSRSNIRLEILIHEGTFGRIYKG-VFKKGDVYEEVMV 60
N S ++ + LR+ + ++ + EG FG++YKG + + V +
Sbjct: 382 NLSDHVALNSKLIERNTLLRINHFTLQDVEFLEELGEGAFGKVYKGQLLQPNKTTITVAI 441
Query: 61 KTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRF 120
K E + L H N++ + ++P + + +L F
Sbjct: 442 KALKENASVKTQQDFKREIELISDLKHQNIVCILGVVLN--KEPYCMLFEYMANGDLHEF 499
Query: 121 LSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNG 180
L S + + + E + + Q++ G+ YL +VH D+AARNC+V+E L +K++D G
Sbjct: 500 LISNSPTEGKSLSQLEFLQIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFG 559
Query: 181 LARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAE 240
L+RD++ DY+ + PV+WM E++L +++T SDVWS G+ LWE+ + G P
Sbjct: 560 LSRDIYSSDYYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYG 619
Query: 241 LDAADVGAFLNGGYRPSQPHNCP 263
+V + S P NCP
Sbjct: 620 FSNQEVINLIRSRQLLSAPENCP 642
>UniRef50_Q8INU0 Cluster: CG14396-PD, isoform D; n=10; Sophophora|Rep:
CG14396-PD, isoform D - Drosophila melanogaster (Fruit
fly)
Length = 1237
Score = 123 bits (296), Expect = 5e-27
Identities = 82/250 (32%), Positives = 125/250 (50%), Gaps = 14/250 (5%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKK--G-DVYEEVMVKTXXXXXXXXXXXXXXXEGLRLY 83
R ++L+ ++ EG FG++ KG + G V VK E L
Sbjct: 770 REKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQ 829
Query: 84 GLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCR----LGQQSA----PATR 135
+ H NV+ + AC + PLLI + S L+ +L R G A P
Sbjct: 830 EVSHPNVIKLLGACTS-SEAPLLIIEYARYGS-LRSYLRLSRKIECAGVDFADGVEPVNV 887
Query: 136 ELVDLGA-QVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLG 194
++V A Q+ G++YL + VH D+AARN ++ + K++D GL RD++ DD +
Sbjct: 888 KMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKR 947
Query: 195 DNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGY 254
+ PVKWMAPE+L + Y++ SDVWS G+ WEL TLG+SP + ++ + L GY
Sbjct: 948 SRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGY 1007
Query: 255 RPSQPHNCPD 264
R +P NC +
Sbjct: 1008 RMDRPENCSE 1017
>UniRef50_Q7Z1L9 Cluster: Neurite outgrowth regulated kinase; n=1;
Aplysia californica|Rep: Neurite outgrowth regulated
kinase - Aplysia californica (California sea hare)
Length = 991
Score = 123 bits (296), Expect = 5e-27
Identities = 56/131 (42%), Positives = 83/131 (63%)
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGD 195
+++ QVA + YL +++VH D+AARN ++D +KV D GL+RD+F D+++
Sbjct: 711 DMLSFARQVAMAMEYLAEKKYVHRDLAARNVLIDYNKVVKVCDFGLSRDIFNDNHYKKLT 770
Query: 196 NENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYR 255
N P+KWMA E+L ++T SDVWS GI LWE+ T+G+SP + AD+ L+ GYR
Sbjct: 771 NGKLPLKWMAIESLRDRMFTTQSDVWSFGILLWEIVTMGASPYPNVALADLYYVLSNGYR 830
Query: 256 PSQPHNCPDEL 266
+P NC EL
Sbjct: 831 MDRPSNCSQEL 841
>UniRef50_Q1JUB8 Cluster: Fibroblast growth factor receptor; n=2;
Obtectomera|Rep: Fibroblast growth factor receptor -
Bombyx mori (Silk moth)
Length = 856
Score = 123 bits (296), Expect = 5e-27
Identities = 79/257 (30%), Positives = 128/257 (49%), Gaps = 21/257 (8%)
Query: 27 RSNIRLEILIHEGTFGRIYK----GVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEG--L 80
R ++ L ++ EG FG++ K G+ K G + V VK E +
Sbjct: 537 RESLSLGKVLGEGEFGKVVKAECIGILKPG-LQSVVAVKMLKEGHTDAEMMALVSEMEMM 595
Query: 81 RLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQ-SAP------- 132
++ G H N++ + C ++ PL + + + NL+ FL + R G + +P
Sbjct: 596 KMIGK-HVNIINLLGCCTQDG--PLYVIVEYAPNGNLREFLRNHRPGNRYESPNEDLKEK 652
Query: 133 ---ATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDD 189
++LV QVA G+ YL +R +H D AARN +V + LK+ D GLA+D+ +D
Sbjct: 653 KTLTQKDLVSFSYQVARGMEYLASRRCIHRDSAARNVLVSDDCVLKIADFGLAKDVHSND 712
Query: 190 YHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAF 249
Y+ PV+WMAPE+L ++T +DVWS G+ LWE+ TLG +P + +
Sbjct: 713 YYRKKTEGRLPVRWMAPESLYHKVFTTQTDVWSFGVLLWEIMTLGGTPYPTVPGQYMYQH 772
Query: 250 LNGGYRPSQPHNCPDEL 266
L+ G+R +P C E+
Sbjct: 773 LSAGHRMEKPPCCSLEI 789
>UniRef50_O15146 Cluster: Muscle, skeletal receptor tyrosine protein
kinase precursor; n=53; Euteleostomi|Rep: Muscle,
skeletal receptor tyrosine protein kinase precursor -
Homo sapiens (Human)
Length = 869
Score = 123 bits (296), Expect = 5e-27
Identities = 83/270 (30%), Positives = 130/270 (48%), Gaps = 24/270 (8%)
Query: 19 QLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVYEE---VMVKTXXXXXXXXXXXXX 75
+L L R+NI I EG FGR+++ YE V VK
Sbjct: 564 KLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADF 623
Query: 76 XXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSS------CRLG-- 127
E + + N++ + CA KP+ + +L FL S C L
Sbjct: 624 QREAALMAEFDNPNIVKLLGVCA--VGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHS 681
Query: 128 ------QQSAP-----ATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKV 176
Q S+P + E + + QVA G++YL ++FVH D+A RNC+V E + +K+
Sbjct: 682 DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKI 741
Query: 177 TDNGLARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSS 236
D GL+R+++ DY+ +N+ P++WM PE++ N+Y+T SDVW+ G+ LWE+ + G
Sbjct: 742 ADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQ 801
Query: 237 PLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
P + +V ++ G S P NCP EL
Sbjct: 802 PYYGMAHEEVIYYVRDGNILSCPENCPVEL 831
>UniRef50_P22182 Cluster: Fibroblast growth factor receptor 1
precursor; n=33; Euteleostomi|Rep: Fibroblast growth
factor receptor 1 precursor - Xenopus laevis (African
clawed frog)
Length = 812
Score = 123 bits (296), Expect = 5e-27
Identities = 69/191 (36%), Positives = 101/191 (52%), Gaps = 13/191 (6%)
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCR-------LGQQSAP----ATR 135
H N++ + AC ++ PL + + NL+ +L + R P + +
Sbjct: 535 HKNIINLLGACTQDG--PLYVIVEYTSKGNLREYLRARRPPAMEYCYNPTCVPDQLLSFK 592
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGD 195
+LV QVA G+ YL ++ +H D+AARN +V E +K+ D GLARD+ DY+
Sbjct: 593 DLVSCAYQVARGMDYLASKKCIHRDLAARNVLVTEDNIMKIADFGLARDIHHIDYYKKTT 652
Query: 196 NENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYR 255
N PVKWMAPE L Y+ SDVWS G+ LWE+ TLG SP + ++ L G+R
Sbjct: 653 NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPMEELFKLLKEGHR 712
Query: 256 PSQPHNCPDEL 266
+P NC +EL
Sbjct: 713 MDKPTNCTNEL 723
>UniRef50_Q4TBR4 Cluster: Chromosome undetermined SCAF7099, whole
genome shotgun sequence; n=2; Tetraodontidae|Rep:
Chromosome undetermined SCAF7099, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 1000
Score = 122 bits (294), Expect = 9e-27
Identities = 49/129 (37%), Positives = 85/129 (65%)
Query: 138 VDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNE 197
+ + Q+A G++YL ++FVH D+A RNC+V E++ +K+ D GL+R+++ DY+ +N+
Sbjct: 843 LSISKQIAAGMAYLSERKFVHRDLATRNCLVGEEMVVKIADFGLSRNIYSADYYKANEND 902
Query: 198 NRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPS 257
P++WM PE++ N+Y+T SD+W+ G+ LWE+ + G P + +V ++ G+ S
Sbjct: 903 AIPIRWMPPESIFYNRYTTESDIWAYGVVLWEIFSHGMQPYYGMGHEEVIYYVRDGHILS 962
Query: 258 QPHNCPDEL 266
P NCP EL
Sbjct: 963 CPENCPLEL 971
>UniRef50_Q5TUS8 Cluster: Tyrosine-protein kinase receptor; n=1;
Anopheles gambiae str. PEST|Rep: Tyrosine-protein kinase
receptor - Anopheles gambiae str. PEST
Length = 2075
Score = 122 bits (294), Expect = 9e-27
Identities = 74/240 (30%), Positives = 115/240 (47%), Gaps = 10/240 (4%)
Query: 35 LIHEGTFGRIYKGVFK--KGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLT 92
L+ G FG +Y+GV K G+ V +KT E + H ++
Sbjct: 1810 LLGSGAFGEVYEGVVKGVDGEAETRVAIKTLKKGAKLHEKQEFLQEAQLMSNFKHKHITR 1869
Query: 93 PMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRL--GQQSAPATRELVDLGAQVACGLSY 150
+ C E LLI +L +L R GQ + +L+ + VA G Y
Sbjct: 1870 LLGVCLEA--DALLIIMELMQGGDLLSYLRRSRSLPGQAARLTMLDLISMCQDVASGCRY 1927
Query: 151 LHVQRFVHADVAARNCVV---DEKLRL-KVTDNGLARDLFPDDYHCLGDNENRPVKWMAP 206
L FVH D+A RNC+V D + R+ K+ D GLARD++ +DY+ PV+WM+P
Sbjct: 1928 LEEMHFVHRDLACRNCLVSSTDPRDRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMSP 1987
Query: 207 ETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
E+L+ +++ SD+W+ G+ LWE+ TLG P + +V + G +P CP+E+
Sbjct: 1988 ESLVDGVFTSQSDIWAFGVLLWEIMTLGEQPYQAKNNVEVLNHVREGGHLDRPKVCPNEM 2047
>UniRef50_A6NNJ8 Cluster: Uncharacterized protein LTK; n=12;
Euarchontoglires|Rep: Uncharacterized protein LTK - Homo
sapiens (Human)
Length = 803
Score = 122 bits (294), Expect = 9e-27
Identities = 79/250 (31%), Positives = 115/250 (46%), Gaps = 10/250 (4%)
Query: 22 VLTTSRSNIRLEILIHEGTFGRIYKGVF--KKGDVYE-EVMVKTXXXXXXXXXXXXXXXE 78
V S +N+ L + G FG +Y+G+ GD +V +KT E
Sbjct: 441 VTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLME 500
Query: 79 GLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCR--LGQQSAPATRE 136
L + H N++ + P LI ++K FL R LGQ S R+
Sbjct: 501 ALIISKFRHQNIVRCVGLSLRAT--PRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRD 558
Query: 137 LVDLGAQVACGLSYLHVQRFVHADVAARNCVVD---EKLRLKVTDNGLARDLFPDDYHCL 193
L+ L +A G YL F+H D+AARNC++ K+ D G+ARD++ Y+
Sbjct: 559 LLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRR 618
Query: 194 GDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGG 253
GD PVKWM PE L+ +++ +D WS G+ LWE+ +LG P +V F+ GG
Sbjct: 619 GDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGG 678
Query: 254 YRPSQPHNCP 263
R P CP
Sbjct: 679 GRMDPPRGCP 688
>UniRef50_Q8AXY6 Cluster: Muscle, skeletal receptor tyrosine protein
kinase precursor; n=18; Gnathostomata|Rep: Muscle,
skeletal receptor tyrosine protein kinase precursor -
Gallus gallus (Chicken)
Length = 947
Score = 122 bits (294), Expect = 9e-27
Identities = 55/144 (38%), Positives = 89/144 (61%), Gaps = 1/144 (0%)
Query: 123 SCRLGQQSAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLA 182
+C L + T +L + QVA G++YL ++FVH D+A RNC+V E + +K+ D GL+
Sbjct: 767 ACLLNPLALCCTSQLC-IAKQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLS 825
Query: 183 RDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELD 242
R+++ DY+ +N+ P++WM PE++ N+Y+T SDVW+ G+ LWE+ + G P +
Sbjct: 826 RNMYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGMQPYYGMA 885
Query: 243 AADVGAFLNGGYRPSQPHNCPDEL 266
+V ++ G S P NCP EL
Sbjct: 886 HEEVIYYVRDGNILSCPDNCPLEL 909
>UniRef50_UPI00015B5971 Cluster: PREDICTED: similar to leukocyte
receptor tyrosine protein kinase; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to leukocyte receptor
tyrosine protein kinase - Nasonia vitripennis
Length = 1472
Score = 122 bits (293), Expect = 1e-26
Identities = 72/247 (29%), Positives = 119/247 (48%), Gaps = 10/247 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEE-VMVKTXXXXXXXXXXXXXXXEGLRLYGL 85
R ++ L + +G FG +++GV+K E V VKT E L +
Sbjct: 917 RDSVTLVKPLGQGAFGEVFQGVYKYSRSEEHPVAVKTLPSVSTSQAEADFMMEALIMSKF 976
Query: 86 VHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPAT---RELVDLGA 142
H N++ + ++ + +++ +LK FL R + P T + L+
Sbjct: 977 EHPNIVQFIGISFDKHPRYIVLELLAG--GDLKNFLREER-PRPDRPTTLTMQSLIMCAY 1033
Query: 143 QVACGLSYLHVQRFVHADVAARNCVVDEK---LRLKVTDNGLARDLFPDDYHCLGDNENR 199
VA G Y+ RF+H D+AARNC++ K +K+ D G+ARD++ DY+ G
Sbjct: 1034 DVAKGCKYMEEARFIHRDIAARNCLLSCKGPGRVVKIADFGMARDIYRSDYYRKGGKAML 1093
Query: 200 PVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQP 259
P+KWM PE+ L ++T +DVW+ G+ LWE+ + G P +V + + G R +P
Sbjct: 1094 PIKWMPPESFLDGIFTTKTDVWAFGVLLWEIMSFGYMPYTGCANREVMSMVTSGGRLERP 1153
Query: 260 HNCPDEL 266
CPD +
Sbjct: 1154 AGCPDPI 1160
>UniRef50_Q674V1 Cluster: Vascular endothelial growth factor receptor;
n=1; Podocoryne carnea|Rep: Vascular endothelial growth
factor receptor - Podocoryne carnea
Length = 1254
Score = 122 bits (293), Expect = 1e-26
Identities = 67/188 (35%), Positives = 97/188 (51%), Gaps = 13/188 (6%)
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCR-----------LGQQSAPATR 135
H N++ + AC + +++ CCP NL FL R ++
Sbjct: 925 HKNIVNLLGACTTNGKLYVILECCPR--GNLLTFLRGKRETFQPVWTKYDTDMENEFTYI 982
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGD 195
+L+ + QVA + +L Q+ VH D+AARN +V +K+ D GLARD++ D+++
Sbjct: 983 DLLMIVIQVAKRMDFLQSQKCVHRDLAARNVLVGPDYIMKIADFGLARDIYKDEFYLKET 1042
Query: 196 NENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYR 255
PVKWMAPE+L Y++ SD+WS GI LWE TLG SP L D+ FL G R
Sbjct: 1043 TGLLPVKWMAPESLFDKVYTSMSDIWSYGIVLWEAFTLGGSPYPGLPTEDLFGFLEDGKR 1102
Query: 256 PSQPHNCP 263
+P CP
Sbjct: 1103 MERPEICP 1110
>UniRef50_Q8IXC7 Cluster: Isoform of FGFR2; n=23; Euteleostomi|Rep:
Isoform of FGFR2 - Homo sapiens (Human)
Length = 709
Score = 122 bits (293), Expect = 1e-26
Identities = 67/191 (35%), Positives = 100/191 (52%), Gaps = 13/191 (6%)
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLG-----------QQSAPATR 135
H N++ + AC ++ PL + + NL+ +L + R + +
Sbjct: 432 HKNIINLLGACTQDG--PLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFK 489
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGD 195
+LV Q+A G+ YL Q+ +H D+AARN +V E +K+ D GLARD+ DY+
Sbjct: 490 DLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTT 549
Query: 196 NENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYR 255
N PVKWMAPE L Y+ SDVWS G+ +WE+ TLG SP + ++ L G+R
Sbjct: 550 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHR 609
Query: 256 PSQPHNCPDEL 266
+P NC +EL
Sbjct: 610 MDKPANCTNEL 620
>UniRef50_Q9YI66 Cluster: Developmental receptor tyrosine kinase;
n=6; Bilateria|Rep: Developmental receptor tyrosine
kinase - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 874
Score = 121 bits (292), Expect = 2e-26
Identities = 57/164 (34%), Positives = 97/164 (59%), Gaps = 2/164 (1%)
Query: 104 PLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRE-LVDLGAQVACGLSYLHVQRFVHADVA 162
P++I H +L FL RLG + +++ L+ +A G+ YL + +H D+A
Sbjct: 578 PMVILPFMKHG-DLHTFLLMSRLGDEPFTVSQQILIQFMLDIARGMEYLSNKNIIHRDLA 636
Query: 163 ARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWS 222
ARNC+++E + + V D GL++ ++ DY+ G PVKW+A E+L N Y+T SDVW+
Sbjct: 637 ARNCMLNENMSVCVADFGLSKKIYSGDYYRQGSVSKLPVKWIALESLADNVYTTQSDVWA 696
Query: 223 LGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
G+T+WE+ T G +P ++ +++ +L G R QP +CP ++
Sbjct: 697 FGVTMWEIMTRGQTPYPGVENSEIYEYLIKGERLKQPPDCPADI 740
>UniRef50_Q5DM52 Cluster: Receptor tyrosine kinase Torso-like
protein; n=1; Tribolium castaneum|Rep: Receptor tyrosine
kinase Torso-like protein - Tribolium castaneum (Red
flour beetle)
Length = 803
Score = 121 bits (292), Expect = 2e-26
Identities = 55/132 (41%), Positives = 84/132 (63%)
Query: 135 RELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLG 194
+ L+ + QVA G+ +L R VH D+AARN +V E +KV+D GL+RD++ D+ +C
Sbjct: 592 KHLLSIARQVALGMEHLAKTRVVHRDLAARNVLVCENHTVKVSDFGLSRDVYQDNVYCKN 651
Query: 195 DNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGY 254
PV+WMA E+L +Y+T SDVWS G+ LWE+ TLG +P + ++++ FL G
Sbjct: 652 GGGKLPVRWMALESLTHQRYTTYSDVWSFGVLLWEIVTLGGTPYVGVHSSELLDFLKSGN 711
Query: 255 RPSQPHNCPDEL 266
R ++P NC +L
Sbjct: 712 RLARPANCSPDL 723
>UniRef50_Q12866 Cluster: Proto-oncogene tyrosine-protein kinase MER
precursor; n=30; root|Rep: Proto-oncogene
tyrosine-protein kinase MER precursor - Homo sapiens
(Human)
Length = 999
Score = 121 bits (291), Expect = 2e-26
Identities = 77/256 (30%), Positives = 129/256 (50%), Gaps = 10/256 (3%)
Query: 19 QLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVYE-EVMVKTXXXXXXXXXXXXXX- 76
+L + R+ + L ++ EG FG + +G K+ D +V VKT
Sbjct: 576 KLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSHREIEEFL 635
Query: 77 XEGLRLYGLVHANVLTPMAACAEEAR----KPLLIYCCPSHSSNLKRFLSSCRL--GQQS 130
E + H NV+ + C E + KP++I + +L +L RL G +
Sbjct: 636 SEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYG-DLHTYLLYSRLETGPKH 694
Query: 131 APATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDY 190
P + L+ +A G+ YL + F+H D+AARNC++ + + + V D GL++ ++ DY
Sbjct: 695 IPL-QTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDY 753
Query: 191 HCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFL 250
+ G PVKW+A E+L Y++ SDVW+ G+T+WE+ T G +P + ++ +L
Sbjct: 754 YRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIRTRGMTPYPGVQNHEMYDYL 813
Query: 251 NGGYRPSQPHNCPDEL 266
G+R QP +C DEL
Sbjct: 814 LHGHRLKQPEDCLDEL 829
>UniRef50_P14616 Cluster: Insulin receptor-related protein precursor
(EC 2.7.10.1) (IRR) (IR- related receptor) [Contains:
Insulin receptor-related protein alpha chain; Insulin
receptor-related protein beta chain]; n=14; Eutheria|Rep:
Insulin receptor-related protein precursor (EC 2.7.10.1)
(IRR) (IR- related receptor) [Contains: Insulin
receptor-related protein alpha chain; Insulin
receptor-related protein beta chain] - Homo sapiens
(Human)
Length = 1297
Score = 121 bits (291), Expect = 2e-26
Identities = 74/248 (29%), Positives = 121/248 (48%), Gaps = 10/248 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEE---VMVKTXXXXXXXXXXXXXXXEGLRLY 83
R I + + +G+FG +Y+G+ + + EE V +KT E +
Sbjct: 976 REQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEASVMK 1035
Query: 84 GLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQS-----APATRELV 138
+V+ + ++ +P L+ +LK L S R ++ PA E++
Sbjct: 1036 AFKCHHVVRLLGVVSQG--QPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALGEMI 1093
Query: 139 DLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNEN 198
+ ++A G++YL +FVH D+AARNC+V + +K+ D G+ RD++ DY+ G
Sbjct: 1094 QMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGL 1153
Query: 199 RPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQ 258
PV+WMAPE+L ++T SDVWS G+ LWE+ TL P L V F+ G +
Sbjct: 1154 LPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEE 1213
Query: 259 PHNCPDEL 266
CP +L
Sbjct: 1214 LEGCPLQL 1221
>UniRef50_UPI0000DB6D22 Cluster: PREDICTED: similar to Alk CG8250-PA;
n=1; Apis mellifera|Rep: PREDICTED: similar to Alk
CG8250-PA - Apis mellifera
Length = 1436
Score = 120 bits (290), Expect = 3e-26
Identities = 69/235 (29%), Positives = 113/235 (48%), Gaps = 8/235 (3%)
Query: 38 EGTFGRIYKGVFK-KGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMAA 96
+G FG +++GV++ + + + V VK E L + H N++ +
Sbjct: 896 QGAFGEVFQGVYRYRRNQEQPVAVKAIPSSSRPQTEADFMMEALIMSKFNHPNIVHFIGV 955
Query: 97 CAEEARKPLLIYCCPSHSSNLKRFLSS--CRLGQQSAPATRELVDLGAQVACGLSYLHVQ 154
E R P I NLK FL R + ++ ++L+ G VA G Y+
Sbjct: 956 SFE--RNPKYIVLELLAGGNLKNFLREERPRADRPTSLRMQDLIMCGFDVANGCKYMEEA 1013
Query: 155 RFVHADVAARNCVVDEK---LRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPETLLQ 211
RF+H D+AARNC++ K +K+ D G+A+D++ DY+ G P+KWM PE+ L
Sbjct: 1014 RFIHRDIAARNCLLTSKGPGRIVKIADFGMAKDIYRSDYYRKGGKAMLPIKWMPPESFLD 1073
Query: 212 NQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
++T +DVW+ G+ LWE+ + G P + + G R +P CPD +
Sbjct: 1074 GIFTTKTDVWAFGVLLWEIMSFGYIPYTGCTNREAMTMVTLGGRLEKPAGCPDPI 1128
>UniRef50_UPI0000D57699 Cluster: PREDICTED: similar to CG18247-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG18247-PA - Tribolium castaneum
Length = 725
Score = 120 bits (290), Expect = 3e-26
Identities = 76/239 (31%), Positives = 118/239 (49%), Gaps = 9/239 (3%)
Query: 30 IRLEILIHEGTFGRIYKGVFKKGDVYE-EVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHA 88
+++ +I EG FG +Y+G + K + E +V +KT E + L H
Sbjct: 450 LKMGRVIGEGEFGSVYEGTYTKRNGEEIKVAIKTVRHEQIETSNAILK-EAHVMMRLNHH 508
Query: 89 NVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGL 148
V+ + +PLL+ L L+ L ++S E AQ+ACG+
Sbjct: 509 CVVKLIGL---SKGRPLLMV---QELVALGSMLNYIILNKESINPNSEFKIWAAQIACGM 562
Query: 149 SYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPD-DYHCLGDNENRPVKWMAPE 207
+YL QRF+H D+AARN ++ + + K++D GL+R L D +Y+ P+KW APE
Sbjct: 563 NYLEEQRFIHRDLAARNILLASQHQAKISDFGLSRALAADHEYYRALQGGKWPLKWYAPE 622
Query: 208 TLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
+ Q+S SDVWS G+ +WE+ + G P EL +D + G R QP CPD +
Sbjct: 623 SYNYGQFSHKSDVWSFGVAIWEMYSFGDVPYGELKGSDAIKIIEDGERLKQPDACPDHI 681
>UniRef50_P04629 Cluster: High affinity nerve growth factor receptor
precursor; n=28; Eumetazoa|Rep: High affinity nerve
growth factor receptor precursor - Homo sapiens (Human)
Length = 796
Score = 120 bits (290), Expect = 3e-26
Identities = 66/192 (34%), Positives = 104/192 (54%), Gaps = 12/192 (6%)
Query: 85 LVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSS----CRL---GQQSAPATR-- 135
L H +++ C E +PLL+ +L RFL S +L G+ AP
Sbjct: 567 LQHQHIVRFFGVCTEG--RPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGL 624
Query: 136 -ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLG 194
+L+ + +QVA G+ YL FVH D+A RNC+V + L +K+ D G++RD++ DY+ +G
Sbjct: 625 GQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVG 684
Query: 195 DNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGY 254
P++WM PE++L +++T SDVWS G+ LWE+ T G P +L + + G
Sbjct: 685 GRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGR 744
Query: 255 RPSQPHNCPDEL 266
+P CP E+
Sbjct: 745 ELERPRACPPEV 756
>UniRef50_P13368 Cluster: Protein sevenless; n=20; Eumetazoa|Rep:
Protein sevenless - Drosophila melanogaster (Fruit fly)
Length = 2554
Score = 120 bits (290), Expect = 3e-26
Identities = 75/252 (29%), Positives = 116/252 (46%), Gaps = 15/252 (5%)
Query: 28 SNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVH 87
S ++L + G FG +Y+G K D E V E + H
Sbjct: 2207 SQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFAELLQEAQLMSNFKH 2266
Query: 88 ANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAP------ATRELVDLG 141
N++ + C + L++ + +L +L + R P + EL+ +
Sbjct: 2267 ENIVCLVGICFDTESISLIME--HMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLAMC 2324
Query: 142 AQVACGLSYLHVQRFVHADVAARNCVV-------DEKLRLKVTDNGLARDLFPDDYHCLG 194
VA G SYL FVH D+A RNC+V D + +K+ D GLARD++ DY+
Sbjct: 2325 IDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKE 2384
Query: 195 DNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGY 254
PV+WM+PE+L+ ++T SDVW+ G+ WE+ TLG P A + +V A + G
Sbjct: 2385 GEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGG 2444
Query: 255 RPSQPHNCPDEL 266
R QP C ++L
Sbjct: 2445 RLQQPPMCTEKL 2456
>UniRef50_A7RZ71 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 624
Score = 120 bits (289), Expect = 4e-26
Identities = 65/192 (33%), Positives = 98/192 (51%), Gaps = 14/192 (7%)
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQ----------QSAPA--T 134
H N++ + AC + PL + + NL++FL R S P+
Sbjct: 395 HKNIINLIGACTQNG--PLYVVVEFAPHGNLRQFLRERRPSDYHRSRSDSSTHSQPSLIV 452
Query: 135 RELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLG 194
R+ + Q+A G+ YL ++ +H D+AARN +V E +K+ D GLAR++ DY+
Sbjct: 453 RDFISFAFQIARGMEYLSFKKCIHRDLAARNILVGEDYVMKIADFGLARNVRDMDYYRKA 512
Query: 195 DNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGY 254
+ P+KW+A E L Y+T SDVW+ GI LWE+ TLG SP + + L GY
Sbjct: 513 TDGRLPIKWLAIEALFDRVYTTQSDVWTFGILLWEIFTLGGSPYPGIPVEKLFELLKSGY 572
Query: 255 RPSQPHNCPDEL 266
R P CPD++
Sbjct: 573 RMQMPQKCPDKM 584
>UniRef50_A3EXK4 Cluster: Fibroblast growth factor receptor a; n=1;
Nematostella vectensis|Rep: Fibroblast growth factor
receptor a - Nematostella vectensis
Length = 441
Score = 120 bits (289), Expect = 4e-26
Identities = 65/192 (33%), Positives = 98/192 (51%), Gaps = 14/192 (7%)
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQ----------QSAPA--T 134
H N++ + AC + PL + + NL++FL R S P+
Sbjct: 180 HKNIINLIGACTQNG--PLYVVVEFAPHGNLRQFLRERRPSDYHRSRSDSSTHSQPSLIV 237
Query: 135 RELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLG 194
R+ + Q+A G+ YL ++ +H D+AARN +V E +K+ D GLAR++ DY+
Sbjct: 238 RDFISFAFQIARGMEYLSFKKCIHRDLAARNILVGEDYVMKIADFGLARNVRDMDYYRKA 297
Query: 195 DNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGY 254
+ P+KW+A E L Y+T SDVW+ GI LWE+ TLG SP + + L GY
Sbjct: 298 TDGRLPIKWLAIEALFDRVYTTQSDVWTFGILLWEIFTLGGSPYPGIPVEKLFELLKSGY 357
Query: 255 RPSQPHNCPDEL 266
R P CPD++
Sbjct: 358 RMQMPQKCPDKM 369
>UniRef50_Q25197 Cluster: Putative insulin-like peptide receptor
precursor; n=8; Eumetazoa|Rep: Putative insulin-like
peptide receptor precursor - Hydra attenuata (Hydra)
(Hydra vulgaris)
Length = 1477
Score = 120 bits (289), Expect = 4e-26
Identities = 74/244 (30%), Positives = 116/244 (47%), Gaps = 5/244 (2%)
Query: 26 SRSNIRLEILIHEGTFGRIYKGVFKK-GDVYE-EVMVKTXXXXXXXXXXXXXXXEGLRLY 83
+R I L + +G+FG +++G+ GD E V VKT E +
Sbjct: 1040 NREKIELIRELGQGSFGMVFEGIAHGIGDHAELRVAVKTTNENASIHDRIQILQEA-SIM 1098
Query: 84 GLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATR-ELVDLGA 142
+ N + + + + P + +LK +L R P R E+ + A
Sbjct: 1099 KAFNCNHVVKLIGVVSQGQ-PTFVVMELMGRGDLKSYLKERRPDDGGIPLMRQEIYQMVA 1157
Query: 143 QVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVK 202
++A G++YL ++FVH D+AARNC+V +K+ D G+ARD++ +Y+ P++
Sbjct: 1158 EIADGMAYLAARKFVHCDLAARNCMVASDFTVKIGDFGMARDIYERNYYRKDGKSLLPIR 1217
Query: 203 WMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNC 262
WMAPE+L +STASDVWS G+ LWE+ TL S P V F+ P C
Sbjct: 1218 WMAPESLKDGIFSTASDVWSFGVVLWEICTLASQPYQGKTNEQVLNFVLSNGHLDYPEGC 1277
Query: 263 PDEL 266
+L
Sbjct: 1278 DYQL 1281
>UniRef50_Q10656-2 Cluster: Isoform b of Q10656 ; n=4;
Caenorhabditis|Rep: Isoform b of Q10656 - Caenorhabditis
elegans
Length = 988
Score = 120 bits (288), Expect = 5e-26
Identities = 57/132 (43%), Positives = 81/132 (61%)
Query: 135 RELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLG 194
R LV QVA G+++L ++ +H D+AARN +V + LK++D GL+RD+ +DY+
Sbjct: 720 RHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLKISDFGLSRDVHCNDYYRKR 779
Query: 195 DNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGY 254
N P+KWMA E L N Y+ SDVWS G+ LWE+ TLG +P + ++ A L GY
Sbjct: 780 GNGRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLGGTPYPTIAMPELYANLKEGY 839
Query: 255 RPSQPHNCPDEL 266
R PH CP E+
Sbjct: 840 RMEPPHLCPQEV 851
>UniRef50_Q25177 Cluster: Receptor protein-tyrosine kinase; n=2;
Hydra vulgaris|Rep: Receptor protein-tyrosine kinase -
Hydra attenuata (Hydra) (Hydra vulgaris)
Length = 891
Score = 120 bits (288), Expect = 5e-26
Identities = 67/190 (35%), Positives = 101/190 (53%), Gaps = 11/190 (5%)
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNL-----KRFLSSCRLGQQSAPATRELVDLG 141
H N++ + +C ++ R ++ CP H + + +R + S + +Q+ + L
Sbjct: 594 HPNIVNLLGSCTKDGRLCAIMEYCP-HGNLVGFLRPRRHVFSLQWEKQALNYDEDFCWLD 652
Query: 142 A-----QVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDN 196
A Q+A G+ +L ++ VH D+AARN +V +K+ D GLARD++ +
Sbjct: 653 AATAAFQIASGMLFLSEKKLVHRDLAARNVLVGPDYIMKLADFGLARDIYLSGVYIKESC 712
Query: 197 ENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRP 256
PVKWMAPE+L Y+ SDVWS GI LWE+ T+G SP L D+ +L G R
Sbjct: 713 GILPVKWMAPESLFDKVYTIKSDVWSFGIVLWEICTMGGSPYPGLPTEDLFEYLTAGKRM 772
Query: 257 SQPHNCPDEL 266
QP CPDEL
Sbjct: 773 CQPVTCPDEL 782
>UniRef50_Q07407 Cluster: Fibroblast growth factor receptor homolog
1 precursor; n=3; Sophophora|Rep: Fibroblast growth
factor receptor homolog 1 precursor - Drosophila
melanogaster (Fruit fly)
Length = 729
Score = 120 bits (288), Expect = 5e-26
Identities = 82/252 (32%), Positives = 121/252 (48%), Gaps = 21/252 (8%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLV 86
RS++ L + EG FGR+ V + MVK E +++ G
Sbjct: 413 RSHLVLGATLGEGAFGRVVMAEVNNAIVAVK-MVKEGHTDDDIASLVREM-EVMKIIGR- 469
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCR-LGQQ----------SAPA-- 133
H N++ + C++ PL + + NLK FL R G+ S PA
Sbjct: 470 HINIINLLGCCSQNG--PLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHV 527
Query: 134 --TRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYH 191
++L+ Q+A G+ YL +R +H D+AARN +V + LK+ D GLARD+ DY+
Sbjct: 528 ITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYY 587
Query: 192 CLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAE-LDAADVGAFL 250
N P+KWMAPE+L + Y + SDVWS GI LWE+ T G P + A ++ +L
Sbjct: 588 RKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYL 647
Query: 251 NGGYRPSQPHNC 262
G R +P C
Sbjct: 648 MSGQRMEKPAKC 659
>UniRef50_Q10656 Cluster: Myoblast growth factor receptor egl-15
precursor; n=7; Caenorhabditis elegans|Rep: Myoblast
growth factor receptor egl-15 precursor - Caenorhabditis
elegans
Length = 1040
Score = 120 bits (288), Expect = 5e-26
Identities = 57/132 (43%), Positives = 81/132 (61%)
Query: 135 RELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLG 194
R LV QVA G+++L ++ +H D+AARN +V + LK++D GL+RD+ +DY+
Sbjct: 772 RHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLKISDFGLSRDVHCNDYYRKR 831
Query: 195 DNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGY 254
N P+KWMA E L N Y+ SDVWS G+ LWE+ TLG +P + ++ A L GY
Sbjct: 832 GNGRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLGGTPYPTIAMPELYANLKEGY 891
Query: 255 RPSQPHNCPDEL 266
R PH CP E+
Sbjct: 892 RMEPPHLCPQEV 903
>UniRef50_UPI0000D55449 Cluster: PREDICTED: similar to CG7223-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG7223-PA, isoform A - Tribolium castaneum
Length = 861
Score = 119 bits (287), Expect = 7e-26
Identities = 84/259 (32%), Positives = 124/259 (47%), Gaps = 23/259 (8%)
Query: 27 RSNIRLEILIHEGTFGRIYK----GVFKKG--DVYEEVMVKTXXXXXXXXXXXXXXXEGL 80
RS + L + EG FG++ K G+ K G + M+K E +
Sbjct: 530 RSMLCLGKSLGEGAFGKVVKAEAVGLLKPGASSIVAVKMLKEGHTDNEMMDLVSEM-EMM 588
Query: 81 RLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPAT------ 134
++ G H N++ + C + PL + + NL+ FL R PA
Sbjct: 589 KMIGK-HNNIINLLGCCTQGG--PLYVVVEYAPYGNLRDFLRQHRPSSGYEPAIGLEEKE 645
Query: 135 ------RELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPD 188
++LV QVA G+ YL +R +H D+AARN +V + LK+ D GLARD+ +
Sbjct: 646 KKTLTQKDLVSFAYQVARGMEYLASRRCIHRDLAARNVLVSDDYFLKIADFGLARDIHCN 705
Query: 189 DYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAAD-VG 247
DY+ + PVKWMAPE L Y+T SDVWS GI LWE+ TLG +P + + + +
Sbjct: 706 DYYRKTTDGRLPVKWMAPEALFHRVYTTQSDVWSYGILLWEIMTLGGTPYPSVPSVEKLF 765
Query: 248 AFLNGGYRPSQPHNCPDEL 266
L G+R +P C E+
Sbjct: 766 QLLRNGHRMEKPPCCSLEI 784
>UniRef50_Q52ZF0 Cluster: Receptor tyrosine kinase-like protein;
n=1; Pristionchus pacificus|Rep: Receptor tyrosine
kinase-like protein - Pristionchus pacificus
Length = 618
Score = 119 bits (287), Expect = 7e-26
Identities = 57/142 (40%), Positives = 87/142 (61%), Gaps = 10/142 (7%)
Query: 134 TRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDE---------KLRLKVTDNGLARD 184
T ELV + Q +++LH +H D+AARNC+V E +L +++ D+ L+RD
Sbjct: 442 THELVSIAVQATRAVAHLHKYGVLHKDIAARNCIVSENAGAKNISERLLVQLVDSSLSRD 501
Query: 185 LFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAA 244
LFP DY +GD E P+KWMA E++ +S+A+D+WSLG+ +WEL + + P +L +
Sbjct: 502 LFPSDYSLVGD-ELLPIKWMAIESIASRNFSSATDIWSLGVLIWELLSCDAPPFPDLPSD 560
Query: 245 DVGAFLNGGYRPSQPHNCPDEL 266
+ L G R QP+NCPD+L
Sbjct: 561 QLLGRLQIGERLPQPYNCPDQL 582
>UniRef50_Q16XX9 Cluster: Tyrosine-protein kinase shark; n=2;
Culicidae|Rep: Tyrosine-protein kinase shark - Aedes
aegypti (Yellowfever mosquito)
Length = 939
Score = 119 bits (287), Expect = 7e-26
Identities = 55/132 (41%), Positives = 80/132 (60%), Gaps = 1/132 (0%)
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFP-DDYHCLG 194
ELV AQ+ACG+ YL FVH D+AARN ++ + + K++D GL+R + DDY+
Sbjct: 760 ELVIWAAQIACGMQYLEQHHFVHRDLAARNILLASRNQAKISDFGLSRAIGAGDDYYRAS 819
Query: 195 DNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGY 254
P+KW APE+ +S ASDVWS G+T+WE+ +LG+ P ++ DV + G
Sbjct: 820 QGGKWPIKWYAPESFNYGTFSHASDVWSFGVTMWEMYSLGAPPYQDMKGVDVIKLIENGQ 879
Query: 255 RPSQPHNCPDEL 266
R SQP CP+ +
Sbjct: 880 RLSQPDLCPENV 891
>UniRef50_A7RGW8 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 337
Score = 119 bits (286), Expect = 9e-26
Identities = 54/132 (40%), Positives = 79/132 (59%), Gaps = 1/132 (0%)
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPD-DYHCLG 194
+L+ Q+A G+ YL + FVH D+AARN ++ E +K++D GL RD++ +YH +
Sbjct: 139 DLLSFARQIAVGMEYLSQKMFVHRDLAARNILICEDNLVKISDFGLTRDVYESSEYHKMH 198
Query: 195 DNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGY 254
+ P+KWMAPE + QN ++T SDVW+ G+ LWE+ TLG SP + L GY
Sbjct: 199 NTGKLPLKWMAPEAIFQNVHTTKSDVWAFGVVLWEIVTLGGSPYPGQSGKEFYKKLKNGY 258
Query: 255 RPSQPHNCPDEL 266
R +P C EL
Sbjct: 259 RMEKPDMCSPEL 270
>UniRef50_UPI0000E471D0 Cluster: PREDICTED: similar to p80 protein,
partial; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to p80 protein, partial -
Strongylocentrotus purpuratus
Length = 526
Score = 118 bits (285), Expect = 1e-25
Identities = 63/182 (34%), Positives = 99/182 (54%), Gaps = 7/182 (3%)
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQ--SAPATRELVDLGAQV 144
H NV++ + C +E KPL I LK+FL R ++ S+ ++L+ + V
Sbjct: 6 HPNVVSLLGICFKE--KPLFIVLEYMEGGELKQFLRDIRPTEEKPSSITMKDLLQITQDV 63
Query: 145 ACGLSYLHVQRFVHADVAARNCVVDEK---LRLKVTDNGLARDLFPDDYHCLGDNENRPV 201
A G YL +RF+H D+AARN ++ K K+ D G+ARD++ DY+ G PV
Sbjct: 64 AQGCRYLESRRFIHRDIAARNILLTTKESGRAAKIADFGMARDIYRADYYRKGGQALLPV 123
Query: 202 KWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHN 261
KWM PE +++ +DVW+ G+ LWE+ +LG P + +V F++ G R + P +
Sbjct: 124 KWMPPEAFQDGIFTSKTDVWAYGVLLWEIISLGFMPYPGMSNQEVIQFVSAGERMNPPRS 183
Query: 262 CP 263
CP
Sbjct: 184 CP 185
>UniRef50_Q4S1S8 Cluster: Chromosome undetermined SCAF14764, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF14764,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 635
Score = 118 bits (285), Expect = 1e-25
Identities = 69/191 (36%), Positives = 99/191 (51%), Gaps = 13/191 (6%)
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFL-----------SSCRLGQQSAPATR 135
H N++ + AC ++ PL + + NL+ +L SS R ++
Sbjct: 411 HKNIINLLGACTQDG--PLYVLVEYASKGNLRDYLRARRPAGLEYWSSSRPVSLASMEIM 468
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGD 195
ELV QVA G++YL ++ +H D+AARN +V E +K+ D GLARD+ DY+
Sbjct: 469 ELVSAAYQVARGMAYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDVHHIDYYKKTT 528
Query: 196 NENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYR 255
N PVKWMAPE L Y+ SDVWS G+ LWE+ TLG SP + ++ L G+R
Sbjct: 529 NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHR 588
Query: 256 PSQPHNCPDEL 266
+P EL
Sbjct: 589 MEKPPTSTQEL 599
>UniRef50_Q4RJ67 Cluster: Chromosome 1 SCAF15039, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 1
SCAF15039, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 978
Score = 118 bits (285), Expect = 1e-25
Identities = 83/273 (30%), Positives = 126/273 (46%), Gaps = 18/273 (6%)
Query: 7 TVTKDRVTDPA-EQLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXX 65
T+T R P E L +I+ E +I EG FG++ K + KK +K
Sbjct: 655 TLTLTRRPKPTPEALTYPILEWEDIKFEDVIGEGNFGQVIKAMVKKDGNKMSAAIKMLKE 714
Query: 66 XXXXXXXXXXXXEGLRLYGL-VHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSC 124
E L L H N++ + AC + I P NL FL
Sbjct: 715 FASENDHRDFAGELEVLCKLGQHPNIINLIGACENRGYLYIAIEYAP--YGNLLDFLRKS 772
Query: 125 RL-----------GQQSAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLR 173
R+ G S +++L+ VA G+ YL ++F+H D+AARN +V + L
Sbjct: 773 RVLETDPAFAKEHGTASTLTSQQLLQFAVDVATGMHYLSDKQFIHRDLAARNVLVGDNLV 832
Query: 174 LKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATL 233
K+ D GL+R ++ + PV+WMA E+L + Y+T SDVWS G+ LWE+ +L
Sbjct: 833 AKIADFGLSRG---EEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSL 889
Query: 234 GSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
G +P + A++ L G+R +P NC DE+
Sbjct: 890 GGTPYCGMTCAELYEKLPQGFRMEKPKNCDDEV 922
>UniRef50_A7RVU0 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 337
Score = 118 bits (285), Expect = 1e-25
Identities = 73/191 (38%), Positives = 102/191 (53%), Gaps = 13/191 (6%)
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSA--PATRE------LV 138
H N++ + AC R ++I P NL FL + R Q T + LV
Sbjct: 103 HKNIVNVLGACTRGRRLMVIIEFAPY--GNLLSFLRARREVYQPTWTKTTNDPEKNYTLV 160
Query: 139 DL---GAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGD 195
DL QV+ G+ +L ++ VH D+AARN +V +KV+D GLARD++ DD +
Sbjct: 161 DLTMASYQVSRGVEFLASRKCVHRDLAARNVLVGPDYVMKVSDFGLARDIYQDDLYVKNT 220
Query: 196 NENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYR 255
+ PVKWMA E+L Y+ SDVWS GI LWE+ TLG +P L + +L+ G R
Sbjct: 221 SGLLPVKWMALESLFDRVYTEKSDVWSFGILLWEIMTLGGTPYPGLPTEQLLDYLSEGQR 280
Query: 256 PSQPHNCPDEL 266
+QP NCP E+
Sbjct: 281 MAQPQNCPLEI 291
>UniRef50_Q2VJ45 Cluster: HOOK3-RET fusion protein; n=3;
Eutheria|Rep: HOOK3-RET fusion protein - Homo sapiens
(Human)
Length = 776
Score = 118 bits (285), Expect = 1e-25
Identities = 82/262 (31%), Positives = 126/262 (48%), Gaps = 24/262 (9%)
Query: 27 RSNIRLEILIHEGTFGRIYKGV--FKKGDV-YEEVMVKTXXXXXXXXXXXXXXXEGLRLY 83
R N+ L + EG FG++ K KG Y V VK E L
Sbjct: 383 RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK 442
Query: 84 GLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCR------LGQQSA------ 131
+ H +V+ AC+++ PLL+ + +L+ FL R LG +
Sbjct: 443 QVNHPHVIKLYGACSQDG--PLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSL 500
Query: 132 --PATR-----ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARD 184
P R +L+ Q++ G+ YL + VH D+AARN +V E ++K++D GL+RD
Sbjct: 501 DHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRD 560
Query: 185 LFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAA 244
++ +D + PVKWMA E+L + Y+T SDVWS G+ LWE+ TLG +P +
Sbjct: 561 VYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPE 620
Query: 245 DVGAFLNGGYRPSQPHNCPDEL 266
+ L G+R +P NC +E+
Sbjct: 621 RLFNLLKTGHRMERPDNCSEEM 642
>UniRef50_P07949 Cluster: Proto-oncogene tyrosine-protein kinase
receptor ret precursor; n=59; Eumetazoa|Rep:
Proto-oncogene tyrosine-protein kinase receptor ret
precursor - Homo sapiens (Human)
Length = 1114
Score = 118 bits (285), Expect = 1e-25
Identities = 82/262 (31%), Positives = 126/262 (48%), Gaps = 24/262 (9%)
Query: 27 RSNIRLEILIHEGTFGRIYKGV--FKKGDV-YEEVMVKTXXXXXXXXXXXXXXXEGLRLY 83
R N+ L + EG FG++ K KG Y V VK E L
Sbjct: 721 RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK 780
Query: 84 GLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCR------LGQQSA------ 131
+ H +V+ AC+++ PLL+ + +L+ FL R LG +
Sbjct: 781 QVNHPHVIKLYGACSQDG--PLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSL 838
Query: 132 --PATR-----ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARD 184
P R +L+ Q++ G+ YL + VH D+AARN +V E ++K++D GL+RD
Sbjct: 839 DHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRD 898
Query: 185 LFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAA 244
++ +D + PVKWMA E+L + Y+T SDVWS G+ LWE+ TLG +P +
Sbjct: 899 VYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPE 958
Query: 245 DVGAFLNGGYRPSQPHNCPDEL 266
+ L G+R +P NC +E+
Sbjct: 959 RLFNLLKTGHRMERPDNCSEEM 980
>UniRef50_UPI0000DB6C99 Cluster: PREDICTED: similar to proto-oncogene
c-ros-1 protein precursor; n=1; Apis mellifera|Rep:
PREDICTED: similar to proto-oncogene c-ros-1 protein
precursor - Apis mellifera
Length = 2105
Score = 118 bits (284), Expect = 2e-25
Identities = 79/246 (32%), Positives = 116/246 (47%), Gaps = 11/246 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFK--KGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYG 84
R I L + G FG +++G K + V +KT E +
Sbjct: 1804 REQITLAKFLGSGAFGEVFQGNAKDLERPGITPVAIKTLRKGASAQEKTEFLQEARLMSH 1863
Query: 85 LVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQ- 143
H +VL + C + PLL+ + +L +L + R Q S L DL A
Sbjct: 1864 FRHKHVLRLLGVCLD-TDPPLLVLEL-MEAGDLLSYLRASRSLQPSDSHALRLQDLLAMC 1921
Query: 144 --VACGLSYLHVQRFVHADVAARNCVVDEKLR----LKVTDNGLARDLFPDDYHCLGDNE 197
VA G YL FVH D+A RNC+V K R +K+ D GLARD++ +DY+
Sbjct: 1922 EDVARGCRYLEELHFVHRDLACRNCLVSAKDRENRVVKIGDFGLARDIYKNDYYRKEGEG 1981
Query: 198 NRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPS 257
PV+WMAPE+L+ +++ SDVW+ G+ +WE+ +LG P +V + G R S
Sbjct: 1982 LLPVRWMAPESLVDGVFTSQSDVWAFGVLMWEITSLGQQPYPARTNIEVLHHVRAGGRLS 2041
Query: 258 QPHNCP 263
+P NCP
Sbjct: 2042 KPLNCP 2047
>UniRef50_Q7KJ08 Cluster: Receptor protein tyrosine kinase ALK splice
variant A; n=9; Diptera|Rep: Receptor protein tyrosine
kinase ALK splice variant A - Drosophila melanogaster
(Fruit fly)
Length = 1701
Score = 118 bits (284), Expect = 2e-25
Identities = 74/246 (30%), Positives = 118/246 (47%), Gaps = 10/246 (4%)
Query: 26 SRSNIRLEILIHEGTFGRIYKGVFKK--GDVYEE-VMVKTXXXXXXXXXXXXXXXEGLRL 82
+R +++L + +G FG +Y +++ GD E V VKT E +
Sbjct: 1189 ARDSLQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIM 1248
Query: 83 YGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQ--SAPATRELVDL 140
H N++ + C + R+P I +L++FL R + S ++L+
Sbjct: 1249 AKFNHPNMVHLIGVCFD--RQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLFC 1306
Query: 141 GAQVACGLSYLHVQRFVHADVAARNCVVDEK---LRLKVTDNGLARDLFPDDYHCLGDNE 197
VA G Y+ +RF+H D+AARNC++ K +K+ D G++RD++ DY+ G
Sbjct: 1307 ALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKA 1366
Query: 198 NRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPS 257
P+KWM PE L +++ +DVWS GI LWE+ +LG SP V + G R
Sbjct: 1367 MLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLG 1426
Query: 258 QPHNCP 263
P CP
Sbjct: 1427 SPTECP 1432
>UniRef50_O76978 Cluster: Tyrosine kinase; n=1; Sycon raphanus|Rep:
Tyrosine kinase - Sycon raphanus
Length = 879
Score = 118 bits (284), Expect = 2e-25
Identities = 80/259 (30%), Positives = 121/259 (46%), Gaps = 12/259 (4%)
Query: 6 QTVTKDRVTDPAEQLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXX 65
Q + + V P LR S NI + I +G FG ++KG K ++ EV VK+
Sbjct: 598 QAILRQPVKKP--DLREYNISHDNILIGEKIGKGNFGDVFKGYLKTHNM--EVAVKSCRS 653
Query: 66 XXX-XXXXXXXXXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSC 124
E L+ Y H N++ + CAE ++PL I N FLS
Sbjct: 654 EDFPDKQKFLQEAEILKQYR--HPNIVELIGVCAE--KEPLYIIMELMAGGN---FLSFL 706
Query: 125 RLGQQSAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARD 184
R + L ++ + A G+ +L + +H D+AARNC+V + LK++D G++R+
Sbjct: 707 RGPEGKRLKVNNLTEMCVEAAAGMVFLEQRNCIHRDLAARNCLVGDNNVLKISDFGMSRE 766
Query: 185 LFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAA 244
Y + P+KW +PE L +Y+T SDVWS GI LWE T GS P ++
Sbjct: 767 EDDGIYTVSSGLKQIPIKWTSPEALNYGRYTTQSDVWSYGILLWETYTYGSGPYPGMNNR 826
Query: 245 DVGAFLNGGYRPSQPHNCP 263
+ + YR +P CP
Sbjct: 827 ETRERIESNYRMPRPELCP 845
>UniRef50_UPI0000E49FB6 Cluster: PREDICTED: similar to RE05926p,
partial; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to RE05926p, partial -
Strongylocentrotus purpuratus
Length = 859
Score = 118 bits (283), Expect = 2e-25
Identities = 72/255 (28%), Positives = 122/255 (47%), Gaps = 17/255 (6%)
Query: 27 RSNIRLEILIHEGTFGRIYK----GVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRL 82
R+ + L + G+F +YK G+ K + + + L +
Sbjct: 310 RNRLTLFNKLGSGSFADVYKAEAVGIITKEEKTIVAVKRLKETATENDKSDLSKELSLYM 369
Query: 83 YGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATR------- 135
Y H N++ + C + +++ P++ NL+ +L R G+ R
Sbjct: 370 YLDPHPNIVNILGCCTDSDPWYIIMEYLPNN--NLQGYLRQIRTGESMTADYRNVKKQKD 427
Query: 136 ----ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYH 191
+L+ G Q+A G+ YL ++ +H D+AARN ++ E KV+D GLARDL +
Sbjct: 428 IPPNDLLTFGVQIARGMEYLASRQCIHRDLAARNILLGEGYVCKVSDFGLARDLEDGQTY 487
Query: 192 CLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLN 251
+ PV+WM+PE+LL N Y++ SDVWS I +WE+ TLGS P + + V ++
Sbjct: 488 EMKSQGRVPVRWMSPESLLHNTYTSQSDVWSFAILIWEIVTLGSHPYPGMSSKQVVKEIS 547
Query: 252 GGYRPSQPHNCPDEL 266
GYR +P +C ++
Sbjct: 548 AGYRLPKPEHCSQDI 562
>UniRef50_Q5IJ68 Cluster: Trk-like receptor tyrosine kinase; n=1;
Aplysia californica|Rep: Trk-like receptor tyrosine
kinase - Aplysia californica (California sea hare)
Length = 865
Score = 118 bits (283), Expect = 2e-25
Identities = 68/242 (28%), Positives = 118/242 (48%), Gaps = 13/242 (5%)
Query: 35 LIHEGTFGRIYKGVFK--KGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLT 92
++ EG FG++++G + +G +V VK E + H N+L
Sbjct: 300 VVGEGAFGQVFRGELRSAEGGACHQVAVKVLKDGASPDAHEDFEREVEIMSAFDHDNILK 359
Query: 93 PMAACAEEAR-KPLLIYCCPSH---SSNLKRFLSSCRLGQQSAPATR--ELVDLGAQVAC 146
+ + P +++ H S L+R R +LV++ Q+A
Sbjct: 360 LLGIVVQGVEGAPYMVFEYMEHGDLSELLRRNDPHLRSADSKTFRLNKSDLVEISVQIAT 419
Query: 147 GLSYLHVQRFVHADVAARNCVVDEK-----LRLKVTDNGLARDLFPDDYHCLGDNENRPV 201
G+ YL QRFVH D+A RNC+V L +K++D G++RD++ +DY+ +G + P+
Sbjct: 420 GMRYLAAQRFVHRDLATRNCLVGTAPPGAGLLVKISDFGMSRDIYTNDYYKIGGSRMLPI 479
Query: 202 KWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHN 261
+WM+PE + +++ SDVW+ G+ LWE+ + G P +V FL+ G +P +
Sbjct: 480 RWMSPEAIKYGRFTCESDVWAYGVVLWEIFSYGRQPYFGHSNEEVIHFLDQGILLQRPED 539
Query: 262 CP 263
CP
Sbjct: 540 CP 541
>UniRef50_O76997 Cluster: Putative neurotrophin receptor LTRK 1
precursor; n=2; Lymnaea stagnalis|Rep: Putative
neurotrophin receptor LTRK 1 precursor - Lymnaea
stagnalis (Great pond snail)
Length = 794
Score = 118 bits (283), Expect = 2e-25
Identities = 78/263 (29%), Positives = 122/263 (46%), Gaps = 21/263 (7%)
Query: 22 VLTTSRSNIRLEIL-----IHEGTFGRIYKG----VFKKGDVYEEVMVKTXXXXXXXXXX 72
V TT +RL+ + I EG FGR++ G + +K + + V VKT
Sbjct: 491 VATTCPKTVRLQTILLMRVIGEGAFGRVFLGTCAHLIQKNE-FAIVAVKTLKGSCSDSLK 549
Query: 73 XXXXXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPS---------HSSNLKRFLSS 123
E L + HAN++T C E + ++ + H +
Sbjct: 550 RDFEREAEMLATIEHANIVTFYGVCTESDQWMMIFEFMENGDLNKYLRMHGPDAAFLKDR 609
Query: 124 CRLGQQSAPATRE-LVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLA 182
+ TRE L+ + Q+A + YL +Q FVH D+A RNC+V L +K+ D G++
Sbjct: 610 DSMDSDEGQLTREQLMKIVLQIASAMEYLALQHFVHRDLATRNCLVGCDLVVKLGDFGMS 669
Query: 183 RDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELD 242
RD++ DY+ + PV+WM PE+++ ++T SDVWS G+TLWE+ T G P E
Sbjct: 670 RDVYTTDYYRVEGTAMLPVRWMPPESIIYRTFTTESDVWSFGVTLWEVFTYGKQPWFEYS 729
Query: 243 AADVGAFL-NGGYRPSQPHNCPD 264
++V + N P C D
Sbjct: 730 NSEVIEHIKNSRTLKRPPRTCTD 752
>UniRef50_O02466 Cluster: Insulin-like peptide receptor precursor (EC
2.7.10.1) (ILP receptor) [Contains: Insulin-like peptide
receptor alpha chain; Insulin-like peptide receptor beta
chain]; n=4; Eukaryota|Rep: Insulin-like peptide receptor
precursor (EC 2.7.10.1) (ILP receptor) [Contains:
Insulin-like peptide receptor alpha chain; Insulin-like
peptide receptor beta chain] - Branchiostoma lanceolatum
(Common lancelet) (Amphioxus)
Length = 1363
Score = 118 bits (283), Expect = 2e-25
Identities = 51/135 (37%), Positives = 82/135 (60%)
Query: 132 PATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYH 191
P ++++ + +A G+SYL ++FVH D+A RNC+V + +K+ D G+ RD++ DY+
Sbjct: 1120 PTFKDIIQMAGVIADGMSYLAAKKFVHRDLACRNCMVAQDRTVKIGDFGMTRDIYETDYY 1179
Query: 192 CLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLN 251
G PV+WM+PE+L +++ SDVWS G+ LWE+ATL S P +V F+
Sbjct: 1180 RKGGKGLLPVRWMSPESLKVGVFTSQSDVWSYGVVLWEMATLASQPYQGKSNEEVLKFVI 1239
Query: 252 GGYRPSQPHNCPDEL 266
G +P CP++L
Sbjct: 1240 DGGMLEKPEGCPNKL 1254
>UniRef50_UPI0000E48523 Cluster: PREDICTED: similar to
protein-tyrosine kinase; n=3; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to protein-tyrosine
kinase - Strongylocentrotus purpuratus
Length = 837
Score = 117 bits (281), Expect = 4e-25
Identities = 70/232 (30%), Positives = 114/232 (49%), Gaps = 10/232 (4%)
Query: 36 IHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMA 95
I +G FG + +G +K+ D + +V +KT E + GL H ++ M
Sbjct: 569 IGQGEFGSVLEGKYKEKDRWVKVALKTLHADHLQTGQKEFLREAKVMCGLDHPCIVKLMG 628
Query: 96 ACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQR 155
C P+++ L FL Q + +L Q+A G+ YL ++
Sbjct: 629 VCLGP---PMMLVQELVSQGALLDFL------QNDSITASDLKLWATQIASGMMYLEGKK 679
Query: 156 FVHADVAARNCVVDEKLRLKVTDNGLARDLFPD-DYHCLGDNENRPVKWMAPETLLQNQY 214
FVH D+AARN +++ K + K++D GL+R + DY+ PVKW APE++ +
Sbjct: 680 FVHRDLAARNILLENKGQAKISDFGLSRATGANNDYYRSTTGGRWPVKWYAPESIYYGTF 739
Query: 215 STASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
S +SDVW G+TLWE+ + G+ P E A+V + G+R ++P CP +
Sbjct: 740 SHSSDVWGFGVTLWEMNSRGAQPYGEKTGAEVIKQIENGHRLNRPEGCPQNV 791
>UniRef50_Q9Y1Y6 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 948
Score = 117 bits (281), Expect = 4e-25
Identities = 77/257 (29%), Positives = 120/257 (46%), Gaps = 20/257 (7%)
Query: 27 RSNIRLEILIHEGTFGRIYK----GVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRL 82
R +R E + +G FG + K GV D V VK E +
Sbjct: 614 RDKVRYEGDLGQGHFGLVVKATALGVVPGRDQCI-VAVKILKEGASLQTKKEFFHEAALM 672
Query: 83 YGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFL-----------SSC-RLGQQS 130
+ H N++ + C E+ +PL + +L FL +SC + G
Sbjct: 673 HSFDHPNIVKLIGVCVEQ--EPLCMIFEFMQLGDLNNFLRHNSPKWQESSASCAKYGGPK 730
Query: 131 APATREL-VDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDD 189
T + V + + GL+YL ++H D+A RNC+V LR+K++D GL++D++ D
Sbjct: 731 CDITTPIQVAMSLDITAGLAYLADNHYIHRDLATRNCLVSGDLRIKISDFGLSQDIYSTD 790
Query: 190 YHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAF 249
Y L +E P++WM PE +L +++T SDVWSLG+ LWEL + G P + V A
Sbjct: 791 YCRLSQSELLPIRWMPPEAILFARFTTQSDVWSLGVVLWELFSYGIQPYYSMSNEQVIAH 850
Query: 250 LNGGYRPSQPHNCPDEL 266
+ G + P CP E+
Sbjct: 851 VRDGNVMNCPDGCPSEI 867
>UniRef50_Q9NH62 Cluster: Tyrosine kinase 5; n=2; Schistosoma
mansoni|Rep: Tyrosine kinase 5 - Schistosoma mansoni
(Blood fluke)
Length = 647
Score = 117 bits (281), Expect = 4e-25
Identities = 79/244 (32%), Positives = 124/244 (50%), Gaps = 16/244 (6%)
Query: 26 SRSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGL 85
S+S+I L + G FG ++KG + G EV VKT +R
Sbjct: 300 SKSSIVLIEKLGAGQFGEVWKGTWN-GTT--EVAVKTLKQGTMTKEDFLKEARIMR--AA 354
Query: 86 VHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVA 145
H ++ A C E+ P+ I + +L ++L R G +LVD+ AQ+A
Sbjct: 355 QHPKLVRLYAVCTED---PIYIVTELMCNGSLLQYL---RDGPGKNLLINQLVDMMAQIA 408
Query: 146 CGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHC--LGDNENR-PVK 202
G++YL + ++H D+AARN +V E +KV D GLAR + +D++C + + P+K
Sbjct: 409 NGMAYLEKEHYIHRDLAARNILVGENNCVKVADFGLARMV--EDHYCTYMAQKSTKFPIK 466
Query: 203 WMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNC 262
W APE L +++ SDVWS GI ++EL TLG P ++ + ++ GYR +P NC
Sbjct: 467 WTAPEAALMGRFTIKSDVWSFGIVIYELITLGQVPYPSMNNTETLHQVSTGYRMPRPVNC 526
Query: 263 PDEL 266
P +
Sbjct: 527 PQPI 530
>UniRef50_Q6R1Y3 Cluster: Src family kinase; n=6; Fungi/Metazoa
group|Rep: Src family kinase - Asterina miniata (Bat
star) (Patiria miniata)
Length = 563
Score = 117 bits (281), Expect = 4e-25
Identities = 79/240 (32%), Positives = 122/240 (50%), Gaps = 12/240 (5%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLV 86
R +I+LE + G FG +++G + G V V VKT ++ L
Sbjct: 299 RRSIKLERKLGNGQFGEVWEGTWN-GTV--RVAVKTLKEGAMDPTAFLQEANIMKK--LR 353
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVAC 146
H ++ +A C+E +P+ I + L +L Q P EL+D+ AQVA
Sbjct: 354 HPKLVALLAVCSEG--EPIYIVTELMTNGCLLDYLHEGEGKQLREP---ELIDITAQVAD 408
Query: 147 GLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAP 206
G++YL QRFVH D+AARN +V + KV D GL+R + +D + + P+KW AP
Sbjct: 409 GMAYLESQRFVHRDLAARNILVGDLRNCKVADFGLSRII--EDEYIAKEGAKMPIKWTAP 466
Query: 207 ETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
E + +++ SDVWS GI ++E+ T G P + +V ++ GYR +P CPD+L
Sbjct: 467 EAINFGKFTIKSDVWSFGILIYEVITKGRVPYPGMVNREVLDQVSRGYRMPKPPECPDQL 526
>UniRef50_Q17LF1 Cluster: Muscle-specific tyrosine kinase receptor;
n=5; Endopterygota|Rep: Muscle-specific tyrosine kinase
receptor - Aedes aegypti (Yellowfever mosquito)
Length = 666
Score = 117 bits (281), Expect = 4e-25
Identities = 71/256 (27%), Positives = 121/256 (47%), Gaps = 13/256 (5%)
Query: 19 QLRVLTTSRSNIRLEILIHEGTFGRIYKGVFK---KGDVYEEVMVKTXXXXXXXXXXXXX 75
+L L R+NI + +G FGR+++ G+ + V VK
Sbjct: 372 KLEKLEFPRNNIIYIKDLGQGAFGRVFQAKAPGLIAGEDFTLVAVKMLKDEASQDLQVDF 431
Query: 76 XXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATR 135
E L H N++ + CA +P+ + +L FL C Q A
Sbjct: 432 EREACLLAEFDHPNIVKLLGVCA--IGRPMCLLFEFMARGDLNEFLRQCSPFAQQNRADN 489
Query: 136 --------ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFP 187
+L+ + +Q+A G+ YL ++FVH D+A RNC++D+ + +K+ D GL+ ++
Sbjct: 490 ITTELSHGDLLSIASQIASGMVYLSERKFVHRDLATRNCLIDDNMVVKIADFGLSHKIYL 549
Query: 188 DDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVG 247
DY+ +N+ P++WM E++L N+Y+ SDVW+ G+ LWE+ + P + +V
Sbjct: 550 QDYYKGDENDAIPIRWMPLESILYNKYTIESDVWAYGVCLWEIFSFAMQPYYGMTHEEVV 609
Query: 248 AFLNGGYRPSQPHNCP 263
F+ G S P N P
Sbjct: 610 KFVKEGNMLSCPENTP 625
>UniRef50_P08923 Cluster: Leukocyte tyrosine kinase receptor
precursor; n=8; Amniota|Rep: Leukocyte tyrosine kinase
receptor precursor - Mus musculus (Mouse)
Length = 888
Score = 117 bits (281), Expect = 4e-25
Identities = 78/246 (31%), Positives = 114/246 (46%), Gaps = 10/246 (4%)
Query: 26 SRSNIRLEILIHEGTFGRIYKGVFK--KGDVYE-EVMVKTXXXXXXXXXXXXXXXEGLRL 82
S +N+ L + G FG +Y+G+ GD V +KT E L +
Sbjct: 502 SPANVTLLRALGHGAFGEVYEGLVTGLPGDSSPLPVAIKTLPELCSHQDELDFLMEALII 561
Query: 83 YGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQ-QSAPAT-RELVDL 140
H N++ + A P LI ++K FL R Q AP T ++L+ L
Sbjct: 562 SKFSHQNIVRCVGLSFRSA--PRLILLELMSGGDMKSFLRHSRPHPGQLAPLTMQDLLQL 619
Query: 141 GAQVACGLSYLHVQRFVHADVAARNCVVD---EKLRLKVTDNGLARDLFPDDYHCLGDNE 197
+A G YL F+H D+AARNC++ K+ D G+ARD++ Y+ G
Sbjct: 620 AQDIAQGCHYLEENHFIHRDIAARNCLLSCSGASRVAKIGDFGMARDIYQASYYRKGGRT 679
Query: 198 NRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPS 257
PVKWM PE LL+ +++ +D WS G+ LWE+ +LG P +V F+ G R
Sbjct: 680 LLPVKWMPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFIATGNRMD 739
Query: 258 QPHNCP 263
P NCP
Sbjct: 740 PPRNCP 745
>UniRef50_UPI0000DB6B52 Cluster: PREDICTED: similar to Ror
CG4926-PA; n=3; Endopterygota|Rep: PREDICTED: similar to
Ror CG4926-PA - Apis mellifera
Length = 529
Score = 116 bits (280), Expect = 5e-25
Identities = 65/209 (31%), Positives = 106/209 (50%), Gaps = 7/209 (3%)
Query: 36 IHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMA 95
I EG FG++YKG GD E V +K E + H N+L+
Sbjct: 211 IGEGCFGKVYKGELCIGDSKEIVAIKVLKETAPREAEEDFMREVDIMSTFGHRNILSLKG 270
Query: 96 ACAEEARK-PLLIYCCPSHSSNLKRFLSSCRLGQQSA-----PATRELVD-LGAQVACGL 148
A E P +++ + + S+ R +S P T E + + Q+A G+
Sbjct: 271 AVLREGNSSPWMVFEYMPYGDLAEVLRSNSRQFNRSPKPEMQPLTEESLHWITIQIAAGM 330
Query: 149 SYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPET 208
+YL QRFVH D+A RNC+V +K+ D G++RD++ DY+ + + P++WM+PE+
Sbjct: 331 TYLSGQRFVHRDLACRNCLVGYDFIVKIADFGMSRDVYTCDYYKIKGSRLLPIRWMSPES 390
Query: 209 LLQNQYSTASDVWSLGITLWELATLGSSP 237
++ +++ SDVWS G+ LWE+ + G P
Sbjct: 391 VMYGRFTLESDVWSFGVVLWEVYSFGKQP 419
>UniRef50_Q4S351 Cluster: Chromosome 4 SCAF14752, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 4 SCAF14752, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 810
Score = 116 bits (280), Expect = 5e-25
Identities = 78/267 (29%), Positives = 125/267 (46%), Gaps = 12/267 (4%)
Query: 3 ASGQTVTKDR---VTDPAEQLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVM 59
+S Q +TK + +P + + + ++ L L+ +G FG ++KG ++ V
Sbjct: 522 SSKQVITKKSGVVLLNPVVKDKKWILNHEDVVLGELLGKGNFGEVFKGTLQRDKT--PVA 579
Query: 60 VKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKR 119
VKT E L H N++ + C + R+P+ I +
Sbjct: 580 VKTCKEDLPSELKIRFLSEARILKQYDHPNIVKLIGVCTQ--RQPIYIVMELVPGGD--- 634
Query: 120 FLSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDN 179
FLS R + T++L+ A G++YL + +H D+AARNC+V + LK++D
Sbjct: 635 FLSYLRKKKDELK-TKQLLRFAVDAAAGMAYLESKNCIHRDLAARNCLVGDNNALKISDF 693
Query: 180 GLARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLA 239
G++R Y G + P+KW APE L +YS+ SDVWS GI LWE +LG P
Sbjct: 694 GMSRQEDDGIYSSSGLKQI-PIKWTAPEALNYGRYSSESDVWSYGILLWETFSLGMCPYP 752
Query: 240 ELDAADVGAFLNGGYRPSQPHNCPDEL 266
+ + GYR + P CPD++
Sbjct: 753 GMTNQQAREQVEKGYRMACPQRCPDDV 779
>UniRef50_Q9Y1Y7 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 709
Score = 116 bits (280), Expect = 5e-25
Identities = 73/248 (29%), Positives = 119/248 (47%), Gaps = 17/248 (6%)
Query: 36 IHEGTFGRIYKGVFKKGDVYEE---VMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLT 92
I +G FG +Y+ ++ Y V VKT E +++ H N+L+
Sbjct: 391 IGQGEFGIVYRAYLREWAKYPSPHLVAVKTIKGETSDSQISQMLEESVKMKDFDHPNILS 450
Query: 93 PMAACAEEARKPLLIYCCPSHSSNL------KRFLSSCRLGQQS--APATRELVDLGAQV 144
+ C P ++ ++ S L + L+ +Q R L+ + Q+
Sbjct: 451 LIGVCIAIESSPYIVMPFMANGSLLSYLKQQRHNLTIANGAEQDLITETQRVLLSICLQI 510
Query: 145 ACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNE----NRP 200
A G+ YL Q+FVH D+AARNC++D +KV D GL+ D++ +Y+ D E P
Sbjct: 511 AKGMEYLASQKFVHRDLAARNCMIDLNNVIKVADFGLSEDMYAKNYYRQSDVEECKVKLP 570
Query: 201 VKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPH 260
++WMAPE+ +S +DVWS G+T WE+ TLG P + + +L+ G R +P
Sbjct: 571 IRWMAPESFHDGVFSEKTDVWSYGVTCWEVFTLGKIPYPGVTPFTLIKYLDEGGRLEKPS 630
Query: 261 N--CPDEL 266
N C D++
Sbjct: 631 NAACSDQI 638
>UniRef50_Q9Y1X7 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 385
Score = 116 bits (280), Expect = 5e-25
Identities = 80/255 (31%), Positives = 121/255 (47%), Gaps = 19/255 (7%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVF-----KKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLR 81
R ++ LE + +G +G +Y+ KKG V VK +
Sbjct: 102 RGDLVLEEKLGDGEYGPVYRAQSYNLPGKKGS--RVVTVKMLLEDASEAHRIAFEKDIAL 159
Query: 82 LYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLG 141
L H NV+ +A C E+ + +L+ S L + RL +Q PA + LVD+
Sbjct: 160 LNSFNHVNVMGVLAVCTGESPQCILLDA-GLPGSLLTHLREAKRLARQKIPAKQLLVDMT 218
Query: 142 A---------QVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHC 192
+ V G++YL Q FV D+AARNC+V R+KV D G+ +FP+ Y C
Sbjct: 219 SPASLLHMADDVCLGMAYLSSQAFVVKDLAARNCIVGADGRVKVADFGVGPSVFPEAY-C 277
Query: 193 LGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNG 252
P++WMA E++ QYSTASD+W+ G+ +WEL T G P E+ +V ++
Sbjct: 278 TLHGRPSPLRWMAAESIESGQYSTASDIWAFGVFIWELFTGGDLPYTEMSDDEVVRYVTK 337
Query: 253 GYRPSQ-PHNCPDEL 266
Q P NCP ++
Sbjct: 338 ECGKLQMPENCPSDV 352
>UniRef50_Q7Q5T3 Cluster: Tyrosine-protein kinase receptor; n=3;
Endopterygota|Rep: Tyrosine-protein kinase receptor -
Anopheles gambiae str. PEST
Length = 646
Score = 116 bits (280), Expect = 5e-25
Identities = 68/244 (27%), Positives = 117/244 (47%), Gaps = 3/244 (1%)
Query: 21 RVLTTSRSNIRLEILIHEGTFGRIYKG-VFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEG 79
RV + ++R + EG FG++YKG + +K V VK E
Sbjct: 365 RVPQYTLQDVRFVEELGEGAFGKVYKGELTQKNGERIFVAVKALKENASAKTQADFKREI 424
Query: 80 LRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVD 139
+ L H N++ + +E +PL + +L FL + + + + + +
Sbjct: 425 ELISDLKHDNIVCILGVVLKE--EPLCMLFEYMAQGDLHEFLIANSPNEGKSLSQLQFLL 482
Query: 140 LGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENR 199
+ Q+ G+ YL +VH D+AARNC+V + L +K++D GL+RD++ DY+ +
Sbjct: 483 IAQQICDGMEYLASHHYVHRDLAARNCLVGDNLTVKISDFGLSRDIYSSDYYRVQSKSLL 542
Query: 200 PVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQP 259
PV+WM E++L +++T SDVWS G+ LWE+ + G P +V + P
Sbjct: 543 PVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGLQPYYGYSNQEVINMVRARQLLPCP 602
Query: 260 HNCP 263
+CP
Sbjct: 603 ESCP 606
>UniRef50_Q70DV1 Cluster: Src tyrosine kinase; n=1; Schistosoma
mansoni|Rep: Src tyrosine kinase - Schistosoma mansoni
(Blood fluke)
Length = 647
Score = 116 bits (280), Expect = 5e-25
Identities = 76/240 (31%), Positives = 123/240 (51%), Gaps = 11/240 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLV 86
+S+I L+ I +G FG ++K V+ K + V VKT + ++ L
Sbjct: 343 KSSIILKEKIGQGQFGEVFKAVWNKTTI---VAVKTLKPSSCDAADFLREAQTMKR--LH 397
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVAC 146
H N++ A C + +P I +L +L S + +A + L+ + A++A
Sbjct: 398 HPNLIQLYAVCTQT--EPFYIVTEYMSKGSLLNYLQS---PEGNALNMQCLIMMAAKIAP 452
Query: 147 GLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAP 206
G++YL +R +H D+AARN +V E+ +K+ D GLAR + +Y P+KW +P
Sbjct: 453 GMAYLESRRHIHRDLAARNVLVGEQHAVKIADFGLARMIHNREYVAHA-GARFPIKWTSP 511
Query: 207 ETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
E ++++ SDVWS GI L E+ T G SP + A+V ++ GYR S+P CP EL
Sbjct: 512 EAANYSRFTIKSDVWSFGILLTEIVTYGRSPYPGMHNAEVLRQVDAGYRMSKPPGCPPEL 571
>UniRef50_Q02763 Cluster: Angiopoietin-1 receptor precursor; n=41;
Euteleostomi|Rep: Angiopoietin-1 receptor precursor -
Homo sapiens (Human)
Length = 1124
Score = 116 bits (280), Expect = 5e-25
Identities = 78/251 (31%), Positives = 120/251 (47%), Gaps = 17/251 (6%)
Query: 28 SNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVH 87
++I+ + +I EG FG++ K KK + + +K E L L H
Sbjct: 822 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGH 881
Query: 88 -ANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRL-----------GQQSAPATR 135
N++ + AC L I P NL FL R+ S +++
Sbjct: 882 HPNIINLLGACEHRGYLYLAIEYAPH--GNLLDFLRKSRVLETDPAFAIANSTASTLSSQ 939
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGD 195
+L+ A VA G+ YL ++F+H D+AARN +V E K+ D GL+R + +
Sbjct: 940 QLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRG---QEVYVKKT 996
Query: 196 NENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYR 255
PV+WMA E+L + Y+T SDVWS G+ LWE+ +LG +P + A++ L GYR
Sbjct: 997 MGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYR 1056
Query: 256 PSQPHNCPDEL 266
+P NC DE+
Sbjct: 1057 LEKPLNCDDEV 1067
>UniRef50_Q26614 Cluster: Fibroblast growth factor receptor
precursor; n=4; Eumetazoa|Rep: Fibroblast growth factor
receptor precursor - Strongylocentrotus purpuratus
(Purple sea urchin)
Length = 972
Score = 116 bits (280), Expect = 5e-25
Identities = 63/188 (33%), Positives = 98/188 (52%), Gaps = 12/188 (6%)
Query: 89 NVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCR----------LGQQSAPATRELV 138
N++ + C +E +++ +H NL+ FL S R L ++L+
Sbjct: 702 NIINLLGCCTQEGPPYVIVEF--AHHGNLRDFLRSRRPPEEYEKSILLTTSQTLTNKDLM 759
Query: 139 DLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNEN 198
+ QVA G+ +L ++ +H D+AARN +V E +K+ D GLARD+ D++ +
Sbjct: 760 SMAYQVARGMDFLASKKCIHRDLAARNVLVTEDFEMKICDFGLARDIHYIDFYRKTTDGR 819
Query: 199 RPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQ 258
PVKWMAPE L ++T SDVWS GI LWE+ TLG +P + + +L G R +
Sbjct: 820 LPVKWMAPEALFDRMFTTQSDVWSFGILLWEIMTLGGTPYPSVPVEQMFDYLRSGKRLEK 879
Query: 259 PHNCPDEL 266
P N E+
Sbjct: 880 PQNTSLEI 887
>UniRef50_Q7YZW6 Cluster: Putative uncharacterized protein; n=3;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 276
Score = 116 bits (279), Expect = 6e-25
Identities = 74/239 (30%), Positives = 122/239 (51%), Gaps = 14/239 (5%)
Query: 34 ILIHEGTFGRIYKGVFK--KGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLV--HAN 89
+L+ EG FG+++KG+ + G V V VK E +++ V H N
Sbjct: 1 MLLGEGAFGQVFKGILRGPNGQVIP-VAVKQLKANAIDEEREEFVRE-IQMMQTVGQHDN 58
Query: 90 VLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPA--TRELVDLGAQVACG 147
++T C +E + +++ P +LK +L + R + S A ++E + Q+ACG
Sbjct: 59 IVTMYGYCMDEQLQCMIMEYVPY--GDLKHYLQNMRKEKDSDSAIDSKEFLSFTNQIACG 116
Query: 148 LSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPE 207
+++L +H D+AARN +V LK++D G++R P Y + P++W++PE
Sbjct: 117 MAHLESVGIIHRDLAARNILVGTGKVLKISDFGMSR---PGVYIKMSKGVI-PLRWLSPE 172
Query: 208 TLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
+ N YS SDVW+ G+ LWE+ATLG P + D+ L G R QP C D++
Sbjct: 173 AIKDNTYSNKSDVWAFGVLLWEIATLGGFPYNNVADKDILNQLTEGMRLEQPAKCSDDM 231
>UniRef50_Q16RK6 Cluster: Receptor protein tyrosine kinase; n=1;
Aedes aegypti|Rep: Receptor protein tyrosine kinase -
Aedes aegypti (Yellowfever mosquito)
Length = 817
Score = 116 bits (279), Expect = 6e-25
Identities = 57/179 (31%), Positives = 103/179 (57%), Gaps = 4/179 (2%)
Query: 92 TPMAACAEEARKPLLIYC-CPSHSSNLKR-FLSSCRLGQQSAP--ATRELVDLGAQVACG 147
+P+ +C + P+++ H + F + C G++ ++++L++ Q+A G
Sbjct: 592 SPINSCEIDTDLPVMVENKLYQHQRRVSNEFDNQCYFGEEEKQPISSKQLIEFARQIAYG 651
Query: 148 LSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPE 207
+ +L R VH D+AARN +V + +K++D GL+RD++ ++ + N P+KW+A E
Sbjct: 652 MEFLARNRVVHRDLAARNILVSDGATVKISDFGLSRDIYQENMYRKTTNGKLPIKWLALE 711
Query: 208 TLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
+L Y++ SDVWS GI L+E+ TLG +P L+ ++ L GYR +P +C +EL
Sbjct: 712 SLTHQVYTSQSDVWSFGIVLYEICTLGGNPYPMLETGNLLLELKAGYRMERPASCCEEL 770
>UniRef50_A6P4V4 Cluster: Tyrosine-protein kinase receptor; n=2; Homo
sapiens|Rep: Tyrosine-protein kinase receptor - Homo
sapiens (Human)
Length = 1310
Score = 116 bits (279), Expect = 6e-25
Identities = 74/245 (30%), Positives = 112/245 (45%), Gaps = 10/245 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFK--KGDVYE-EVMVKTXXXXXXXXXXXXXXXEGLRLY 83
R NI L + G FG +Y+G D +V VKT E L +
Sbjct: 803 RKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIIS 862
Query: 84 GLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRL--GQQSAPATRELVDLG 141
H N++ + + + +L+ +LK FL R Q S+ A +L+ +
Sbjct: 863 KFNHQNIVRCIGVSLQSLPRFILLELMAG--GDLKSFLRETRPRPSQPSSLAMLDLLHVA 920
Query: 142 AQVACGLSYLHVQRFVHADVAARNCVVD---EKLRLKVTDNGLARDLFPDDYHCLGDNEN 198
+ACG YL F+H D+AARNC++ K+ D G+ARD++ Y+ G
Sbjct: 921 RDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAM 980
Query: 199 RPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQ 258
PVKWM PE ++ +++ +D WS G+ LWE+ +LG P +V F+ G R
Sbjct: 981 LPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDP 1040
Query: 259 PHNCP 263
P NCP
Sbjct: 1041 PKNCP 1045
>UniRef50_Q9UM73 Cluster: ALK tyrosine kinase receptor precursor;
n=37; Euteleostomi|Rep: ALK tyrosine kinase receptor
precursor - Homo sapiens (Human)
Length = 1620
Score = 116 bits (279), Expect = 6e-25
Identities = 74/245 (30%), Positives = 112/245 (45%), Gaps = 10/245 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFK--KGDVYE-EVMVKTXXXXXXXXXXXXXXXEGLRLY 83
R NI L + G FG +Y+G D +V VKT E L +
Sbjct: 1113 RKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIIS 1172
Query: 84 GLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRL--GQQSAPATRELVDLG 141
H N++ + + + +L+ +LK FL R Q S+ A +L+ +
Sbjct: 1173 KFNHQNIVRCIGVSLQSLPRFILLELMAG--GDLKSFLRETRPRPSQPSSLAMLDLLHVA 1230
Query: 142 AQVACGLSYLHVQRFVHADVAARNCVVD---EKLRLKVTDNGLARDLFPDDYHCLGDNEN 198
+ACG YL F+H D+AARNC++ K+ D G+ARD++ Y+ G
Sbjct: 1231 RDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAM 1290
Query: 199 RPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQ 258
PVKWM PE ++ +++ +D WS G+ LWE+ +LG P +V F+ G R
Sbjct: 1291 LPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDP 1350
Query: 259 PHNCP 263
P NCP
Sbjct: 1351 PKNCP 1355
>UniRef50_UPI00015B4CAE Cluster: PREDICTED: similar to
ENSANGP00000019144; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000019144 - Nasonia
vitripennis
Length = 1220
Score = 116 bits (278), Expect = 8e-25
Identities = 79/257 (30%), Positives = 126/257 (49%), Gaps = 21/257 (8%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEE----VMVKTXXXXXXXXXXXXXXXEGLRL 82
R +RL+ ++ EG FG+++K ++ V VKT E L +
Sbjct: 919 RDKLRLQTVLGEGNFGQVWKAEADDLTGHQGTTRLVAVKTVKEGASDREKEDLVRE-LEI 977
Query: 83 YGLV--HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQ--------SAP 132
V H NV+T + C E+ L++ L +L R Q +A
Sbjct: 978 MQRVGSHPNVVTLLGCCTEQEPHYLILEYVMY--GKLLAYLRDHRTRQDFYNFSEDSAAL 1035
Query: 133 ATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHC 192
+R+L G VA G+ YL ++ +H D+AARN +VD K+ D G++R +D
Sbjct: 1036 TSRDLTVFGYCVARGMEYLASKKIIHRDLAARNVLVDHNKLCKIADFGMSR-FANEDGEV 1094
Query: 193 LGDNENR---PVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAF 249
+ R P++WMAPE+L+ + ++T +DVWS GI +WE+ TLGS+P ++ A +V
Sbjct: 1095 IETRHGRNALPIRWMAPESLIYSLFTTKTDVWSFGILMWEIVTLGSTPYPDMTAREVMRS 1154
Query: 250 LNGGYRPSQPHNCPDEL 266
+ GYR +P +C EL
Sbjct: 1155 VQSGYRLERPSHCRSEL 1171
>UniRef50_Q5I4E2 Cluster: Bm-DAF-2 precursor; n=1; Brugia malayi|Rep:
Bm-DAF-2 precursor - Brugia malayi (Filarial nematode
worm)
Length = 1456
Score = 116 bits (278), Expect = 8e-25
Identities = 80/252 (31%), Positives = 123/252 (48%), Gaps = 18/252 (7%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLV 86
RS I LE I GTFG++Y+G GD + + T RL+ L+
Sbjct: 1041 RSAIHLEDEIGRGTFGKVYRGY---GDNCKSYLGVTFGECAIKTVSETANSAE-RLHFLI 1096
Query: 87 HANVL----TPMAAC---AEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQS------APA 133
A+V+ TP +P+L+ NL+ +L S R + P
Sbjct: 1097 EASVMKQFNTPFIVKLYGVVSDGQPVLVVMEMMKKGNLRDYLRSRRPNAEENVNGLPVPG 1156
Query: 134 TRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCL 193
+ +QVA G++YL +F H D+AARNC+V+E +K+ D G+ARD++ +Y+
Sbjct: 1157 AIDFFRWASQVADGMAYLESLKFCHRDLAARNCMVNEFDTVKIGDFGMARDIYYHEYYKP 1216
Query: 194 GDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGG 253
PV+WMAPE+L+ +++ SDVWS GITL+E+ TL P L V ++
Sbjct: 1217 AGKRLMPVRWMAPESLMDGKFTMKSDVWSYGITLYEMLTLAQQPYLGLANESVFDYIGVK 1276
Query: 254 YR-PSQPHNCPD 264
+ ++P CPD
Sbjct: 1277 KKILTRPTGCPD 1288
>UniRef50_P43403 Cluster: Tyrosine-protein kinase ZAP-70; n=55;
Euteleostomi|Rep: Tyrosine-protein kinase ZAP-70 - Homo
sapiens (Human)
Length = 619
Score = 116 bits (278), Expect = 8e-25
Identities = 75/263 (28%), Positives = 129/263 (49%), Gaps = 10/263 (3%)
Query: 7 TVTKDRVTDPAE-QLRVLTTSRSNIRL-EILIHEGTFGRIYKGVFKKGDVYEEVMVKTXX 64
+V + +DP E + + L R N+ + +I + G FG + +GV++ +V +K
Sbjct: 313 SVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLK 372
Query: 65 XXXXXXXXXXXXXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSC 124
E ++ L + ++ + C EA L++ + L +FL
Sbjct: 373 QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA---LMLVMEMAGGGPLHKFL--- 426
Query: 125 RLGQQSAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARD 184
+G++ + +L QV+ G+ YL + FVH D+AARN ++ + K++D GL++
Sbjct: 427 -VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKA 485
Query: 185 LFPDD-YHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDA 243
L DD Y+ P+KW APE + ++S+ SDVWS G+T+WE + G P ++
Sbjct: 486 LGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG 545
Query: 244 ADVGAFLNGGYRPSQPHNCPDEL 266
+V AF+ G R P CP EL
Sbjct: 546 PEVMAFIEQGKRMECPPECPPEL 568
>UniRef50_P16591 Cluster: Proto-oncogene tyrosine-protein kinase
FER; n=109; root|Rep: Proto-oncogene tyrosine-protein
kinase FER - Homo sapiens (Human)
Length = 822
Score = 116 bits (278), Expect = 8e-25
Identities = 75/241 (31%), Positives = 111/241 (46%), Gaps = 10/241 (4%)
Query: 26 SRSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGL 85
S ++ L L+ +G FG +YKG K V VKT E L
Sbjct: 559 SHEDVILGELLGKGNFGEVYKGTLKDKT---SVAVKTCKEDLPQELKIKFLQEAKILKQY 615
Query: 86 VHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVA 145
H N++ + C + R+P+ I + FL ++ ++LV A
Sbjct: 616 DHPNIVKLIGVCTQ--RQPVYIIMELVSGGDFLTFLRR----KKDELKLKQLVKFSLDAA 669
Query: 146 CGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMA 205
G+ YL + +H D+AARNC+V E LK++D G++R Y G + P+KW A
Sbjct: 670 AGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQI-PIKWTA 728
Query: 206 PETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDE 265
PE L +YS+ SDVWS GI LWE +LG P + + GYR S P +CP++
Sbjct: 729 PEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPED 788
Query: 266 L 266
+
Sbjct: 789 I 789
>UniRef50_UPI00015B6133 Cluster: PREDICTED: similar to protein
tyrosine kinase; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to protein tyrosine kinase - Nasonia
vitripennis
Length = 739
Score = 115 bits (277), Expect = 1e-24
Identities = 80/260 (30%), Positives = 118/260 (45%), Gaps = 10/260 (3%)
Query: 8 VTKDRVTDPAEQLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKK-GDVYEEVMVKTXXXX 66
+ D T P Q+ V NI L ++ EG FG +Y+G+F E V +K
Sbjct: 445 IENDNETVPLTQVFV---PGENIILGEVLGEGEFGAVYEGLFDSPSGTQEPVAIKMLRDT 501
Query: 67 XXXXXXXXXXXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRL 126
E RL + + + + +E PLL+ +L L+
Sbjct: 502 HNIATREEFLREA-RLMMTFNHHCIVKLIGFSEGP--PLLMV---QELVSLGSMLAYLLE 555
Query: 127 GQQSAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLF 186
EL +Q+ACG+ YL R VH D+AARN ++ K + K++D GL+R
Sbjct: 556 FPDRINPNYELKVWASQIACGMKYLEEIRLVHRDLAARNILLASKHQAKISDFGLSRTFG 615
Query: 187 PDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADV 246
+DY+ P+KW APE+ +S ASDVWS GITLWE+ + G P + +V
Sbjct: 616 SNDYYKATAGGKWPIKWYAPESYNYGTFSHASDVWSYGITLWEMFSYGEQPYGDRRGTEV 675
Query: 247 GAFLNGGYRPSQPHNCPDEL 266
+ G R +QP CPD +
Sbjct: 676 IDLVEKGDRLAQPEQCPDHV 695
>UniRef50_Q9GRH1 Cluster: Tyrosine-protein kinase receptor; n=4;
Porifera|Rep: Tyrosine-protein kinase receptor - Sycon
raphanus
Length = 614
Score = 115 bits (277), Expect = 1e-24
Identities = 80/249 (32%), Positives = 116/249 (46%), Gaps = 22/249 (8%)
Query: 36 IHEGTFGRIYKGVF---KKGDVYEEVMVKTXXXXXXXXXXXXXXXEG-----------LR 81
+ EG FG++Y+GV + GD+ V +KT E +R
Sbjct: 249 VGEGAFGKVYEGVLATIEDGDL--TVAIKTLSTCENVAQRNAFLGEASIMKKFDCPYVMR 306
Query: 82 LYGLVHA--NVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVD 139
L+GLV L M AE + L+ C P RF S + AP+ +
Sbjct: 307 LFGLVSTVNKPLVVMEFMAEGDLRGYLMKCRPQEEQFATRFSGSSQ-STSKAPSVDQFKL 365
Query: 140 LGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENR 199
Q+A G++++H + FVH D+AARNC++ L LK+ D G RD++ DY+
Sbjct: 366 WALQLAKGMAHVHEKHFVHRDLAARNCMIATNLVLKIGDFGFTRDIYESDYYRKTGGGVL 425
Query: 200 PVKWMAPETLLQNQYSTASDVWSLGITLWELATL-GSSPLAELDAADVGAFLNGGY--RP 256
PV+WM PE L Y SDVWS GI LWE+ATL G + E + + G+ RP
Sbjct: 426 PVRWMGPECLRDGLYIPESDVWSYGIVLWEMATLRGPAIPGESHEEVMNMVIGSGHMERP 485
Query: 257 SQPHNCPDE 265
+ H+ P +
Sbjct: 486 TVLHDFPSQ 494
>UniRef50_Q95YD4 Cluster: Protein kinase protein 32, isoform a; n=4;
Caenorhabditis|Rep: Protein kinase protein 32, isoform a
- Caenorhabditis elegans
Length = 867
Score = 115 bits (277), Expect = 1e-24
Identities = 75/242 (30%), Positives = 114/242 (47%), Gaps = 10/242 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEE--VMVKTXXXXXXXXXXXXXXXEGLRLYG 84
R I L+ LI G FG +YK V+ + E V VK E +
Sbjct: 364 RELITLKELIGGGQFGNVYKAVYHDLEKDERIAVAVKVCKTDAEPADTQLILQESSLMRN 423
Query: 85 LVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQV 144
H+N++ + C ++ P+ + + L+ +L ++ R L +Q+
Sbjct: 424 FRHSNIIQLIGVCVDQ---PMWLVLELAPKGELREYLQQ----EKDWLPLRILTLFCSQI 476
Query: 145 ACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWM 204
L YLH RFVH D+AARN +V +K+ D GL+R L D + + P+KW+
Sbjct: 477 CDSLVYLHSTRFVHRDIAARNILVCSPQCVKLADFGLSRALDYDAVYTASRGK-LPIKWL 535
Query: 205 APETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPD 264
APE++ Q+S ASDVW G+ +WE+ +LG P A + +DV + G RP P CP
Sbjct: 536 APESVNYRQFSMASDVWMFGVCMWEIFSLGVKPWAGVTNSDVIMHIEQGSRPPCPEKCPT 595
Query: 265 EL 266
L
Sbjct: 596 AL 597
>UniRef50_Q7PYY7 Cluster: ENSANGP00000019144; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000019144 - Anopheles gambiae
str. PEST
Length = 687
Score = 115 bits (277), Expect = 1e-24
Identities = 75/252 (29%), Positives = 120/252 (47%), Gaps = 14/252 (5%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMV---KTXXXXXXXXXXXXXXXEGLRLY 83
R +++ ++ EG FG++++ D +E V V KT E L
Sbjct: 381 RHRLKVFNILGEGAFGQVWRCEATDIDGHEGVSVTAVKTLKENASEAERNDLLSELQVLK 440
Query: 84 GLV-HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRL--------GQQSAPAT 134
L H NV+ + C E + P+ + + L+ FL + R+ G+ +
Sbjct: 441 SLEPHINVVRLLGCCTE--KDPIFVILEYVNMGKLQTFLRNSRVEKHYGNTHGKSKILTS 498
Query: 135 RELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLG 194
+L QVA G+ +L + +H D+AARN ++ + KV D G ARD+ +
Sbjct: 499 GDLTSFMYQVARGMDFLTSRGIIHRDLAARNILITDDHTCKVADFGFARDIVTSKVYERK 558
Query: 195 DNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGY 254
P++WMA E+L N ++ SD+WS GI +WE+ TLGS+P + AADV + GY
Sbjct: 559 SEGRLPIRWMATESLYDNIFTVKSDIWSFGILMWEIVTLGSTPYPGIAAADVMRKVRDGY 618
Query: 255 RPSQPHNCPDEL 266
R +P +C EL
Sbjct: 619 RLEKPEHCRREL 630
>UniRef50_UPI00015B4DC3 Cluster: PREDICTED: similar to receptor
tyrosine kinase Torso-like protein; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to receptor tyrosine
kinase Torso-like protein - Nasonia vitripennis
Length = 590
Score = 115 bits (276), Expect = 1e-24
Identities = 54/131 (41%), Positives = 79/131 (60%)
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGD 195
+L++ QVA G+ +L R VH D+AARN +V +K++D GL+RD++ ++ +
Sbjct: 389 DLLNFARQVASGMEFLSSNRIVHRDLAARNVLVCADQTVKISDFGLSRDIYQENVYKKQT 448
Query: 196 NENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYR 255
N P+KWMA E L Y+T SDVWS G+ L+E+ TLG +P L +V FL GYR
Sbjct: 449 NGKLPIKWMAIEALTHQVYTTHSDVWSFGVLLYEIVTLGGNPYPGLPCCEVLHFLKSGYR 508
Query: 256 PSQPHNCPDEL 266
+P NC +L
Sbjct: 509 MERPSNCGFQL 519
>UniRef50_Q4S8H3 Cluster: Chromosome 2 SCAF14705, whole genome
shotgun sequence; n=3; Tetraodontidae|Rep: Chromosome 2
SCAF14705, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 1531
Score = 115 bits (276), Expect = 1e-24
Identities = 70/232 (30%), Positives = 111/232 (47%), Gaps = 12/232 (5%)
Query: 16 PAEQLRVL-TTSRSNIRLEIL--IHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXX 72
P+ +++L TT S L L I G FG++ G G +V+VK
Sbjct: 46 PSRSVQLLKTTDLSRHHLLYLKEIGNGWFGKVLLGEVNTGLNTTQVVVKELKSSAGVQDQ 105
Query: 73 XXXXXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAP 132
E L H +L ++ C E L++ CP ++K +L SCR + P
Sbjct: 106 MHFLEEAQPYRTLQHHALLQCLSQCTEVTPYLLVMEFCPL--GDVKGYLQSCRAAENMTP 163
Query: 133 ATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHC 192
L + +A GL +LH F H+D+A RNC++ + +K+ D GL+ + +DY+
Sbjct: 164 EPLVLQQMACDIASGLLHLHKHNFTHSDLALRNCLLSANISVKIGDYGLSHLKYKEDYYV 223
Query: 193 LGDNENRPVKWMAPE-------TLLQNQYSTASDVWSLGITLWELATLGSSP 237
D + P++W+APE LL + S++WSLG+T+WEL LG+ P
Sbjct: 224 TSDQKYVPIRWIAPELVDEVHGNLLVADQTKQSNMWSLGVTIWELFELGNQP 275
>UniRef50_A7RNB1 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 280
Score = 115 bits (276), Expect = 1e-24
Identities = 51/132 (38%), Positives = 82/132 (62%)
Query: 135 RELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLG 194
++L+ L A G+ ++ RFVH D+A RN +V E L K+TD GL+RD++ D +
Sbjct: 121 KDLLKLALGAARGMRHISGNRFVHRDLATRNVLVTEDLTAKITDFGLSRDIYSDGIYLNA 180
Query: 195 DNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGY 254
P+KWMAPE+LL Y+T SD+WS G+ +WE+ + G+ P + + ++ + L G+
Sbjct: 181 KGGKLPLKWMAPESLLDYVYTTQSDIWSFGVLMWEVWSFGAMPYSAVVPNELLSMLMSGF 240
Query: 255 RPSQPHNCPDEL 266
R S+P CP+E+
Sbjct: 241 RLSRPPLCPEEI 252
>UniRef50_Q2VXS7 Cluster: Proto-oncogene c-fes variant 4; n=77;
Eutheria|Rep: Proto-oncogene c-fes variant 4 - Homo
sapiens (Human)
Length = 752
Score = 115 bits (276), Expect = 1e-24
Identities = 71/229 (31%), Positives = 106/229 (46%), Gaps = 8/229 (3%)
Query: 36 IHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMA 95
I G FG ++ G + + V VK+ E L H N++ +
Sbjct: 497 IGRGNFGEVFSGRLRADNTL--VAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIG 554
Query: 96 ACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQR 155
C + ++P+ I + FL + + + + L+ + A G+ YL +
Sbjct: 555 VCTQ--KQPIYIVMELVQGGDFLTFLRT----EGARLRVKTLLQMVGDAAAGMEYLESKC 608
Query: 156 FVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYS 215
+H D+AARNC+V EK LK++D G++R+ Y G + PVKW APE L +YS
Sbjct: 609 CIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGSRQVPVKWTAPEALNYGRYS 668
Query: 216 TASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPD 264
+ SDVWS GI LWE +LG+SP L F+ G R P CPD
Sbjct: 669 SESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPD 717
>UniRef50_Q4SK07 Cluster: Tyrosine-protein kinase receptor; n=2;
Tetraodontidae|Rep: Tyrosine-protein kinase receptor -
Tetraodon nigroviridis (Green puffer)
Length = 1084
Score = 114 bits (275), Expect = 2e-24
Identities = 75/247 (30%), Positives = 116/247 (46%), Gaps = 12/247 (4%)
Query: 26 SRSNIRLEILIHEGTFGRIYKG--VFKKGDVYE-EVMVKTXXXXXXXXXXXXXXXEGLRL 82
SR NI L + G FG +Y+G V G+ +V VKT E L +
Sbjct: 495 SRRNISLTRGLGHGAFGEVYEGLAVGIPGEPSPLQVAVKTLPEVCSEQDELDFLMEALII 554
Query: 83 YGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDL-- 140
H N++ + + + +L+ +LK F+ R + P++ +VDL
Sbjct: 555 SKFSHQNIVRCVGVSLQAMPRFILLELMTG--GDLKTFMRETR-PRPEHPSSLTMVDLLN 611
Query: 141 -GAQVACGLSYLHVQRFVHADVAARNCVVDEK---LRLKVTDNGLARDLFPDDYHCLGDN 196
+A G YL +F+H D+AARNC++ K K+ D G+ARD++ Y+ G
Sbjct: 612 IARDIAKGCQYLEENQFIHRDIAARNCLLTCKGPGRVAKIGDFGMARDIYRASYYRKGGR 671
Query: 197 ENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRP 256
PVKWM PE ++ +++ +D WS G+ LWE+ +LG P +V F+ G R
Sbjct: 672 AMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSRSNQEVLEFVTNGGRM 731
Query: 257 SQPHNCP 263
P NCP
Sbjct: 732 DPPKNCP 738
>UniRef50_Q01974 Cluster: Tyrosine-protein kinase transmembrane
receptor ROR2 precursor; n=36; Euteleostomi|Rep:
Tyrosine-protein kinase transmembrane receptor ROR2
precursor - Homo sapiens (Human)
Length = 943
Score = 114 bits (275), Expect = 2e-24
Identities = 77/260 (29%), Positives = 123/260 (47%), Gaps = 16/260 (6%)
Query: 18 EQLRVLTTSRSNIRLEILIHEGTFGRIYKG-VF--KKGDVYEEVMVKTXXXXXXXXXXXX 74
+Q ++ S S +R + E FG++YKG +F G+ + V +KT
Sbjct: 461 KQAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREE 520
Query: 75 XXXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFL----SSCRLGQ-- 128
E + L H NV+ + ++ ++ C SH +L FL +G
Sbjct: 521 FRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYC-SHG-DLHEFLVMRSPHSDVGSTD 578
Query: 129 -----QSAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLAR 183
+SA + V L AQ+A G+ YL VH D+A RN +V +KL +K++D GL R
Sbjct: 579 DDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFR 638
Query: 184 DLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDA 243
+++ DY+ L N P++WMAPE ++ ++S SD+WS G+ LWE+ + G P
Sbjct: 639 EVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSN 698
Query: 244 ADVGAFLNGGYRPSQPHNCP 263
DV + P +CP
Sbjct: 699 QDVVEMIRNRQVLPCPDDCP 718
>UniRef50_UPI0000F2052A Cluster: PREDICTED: similar to anaplastic
lymphoma kinase (Ki-1),; n=1; Danio rerio|Rep: PREDICTED:
similar to anaplastic lymphoma kinase (Ki-1), - Danio
rerio
Length = 1387
Score = 114 bits (274), Expect = 3e-24
Identities = 74/245 (30%), Positives = 114/245 (46%), Gaps = 10/245 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKG--VFKKGDVYE-EVMVKTXXXXXXXXXXXXXXXEGLRLY 83
R NI L + G FG +Y+G V G+ +V VKT E L +
Sbjct: 792 RRNISLTRGLGHGAFGEVYEGLAVGIPGEPSPMQVAVKTLPEVCSEQDELDFLMEALIIS 851
Query: 84 GLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCR--LGQQSAPATRELVDLG 141
H N++ + + +L+ +LK FL R L S+ +L+++
Sbjct: 852 KFSHQNIVRCIGVSLQALPHFILLELMAG--GDLKSFLRETRPRLEHPSSLTMVDLLNIA 909
Query: 142 AQVACGLSYLHVQRFVHADVAARNCVVDEK---LRLKVTDNGLARDLFPDDYHCLGDNEN 198
+A G YL +F+H D+AARNC++ K K+ D G+ARD++ Y+ G
Sbjct: 910 RDIARGCQYLEENQFIHRDIAARNCLLTCKGPGRVAKIGDFGMARDIYRASYYRKGGRAM 969
Query: 199 RPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQ 258
PVKWM PE ++ +++ +D WS G+ LWE+ +LG P +V F+ G R
Sbjct: 970 LPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSRSNQEVLEFVTNGGRMDP 1029
Query: 259 PHNCP 263
P NCP
Sbjct: 1030 PKNCP 1034
>UniRef50_Q17J18 Cluster: Tyrosine-protein kinase; n=4;
Endopterygota|Rep: Tyrosine-protein kinase - Aedes
aegypti (Yellowfever mosquito)
Length = 959
Score = 114 bits (274), Expect = 3e-24
Identities = 77/254 (30%), Positives = 119/254 (46%), Gaps = 21/254 (8%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFK---KGDVYEEVMVKTXXXXXXXXXXXXXX--XEGLR 81
RS + L + EG FG++ KG V VK E ++
Sbjct: 623 RSKLVLGKSLGEGAFGKVVMAEANGLVKGQASTVVAVKMLKEGHTDADVKDLVCEMEVMK 682
Query: 82 LYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLG------------QQ 129
+ G H N++ + C ++ PL + + NLK FL S R G ++
Sbjct: 683 MIGK-HVNIINLLGCCCKDG--PLYVIVEYAPHGNLKDFLRSHRFGTANYEDMISGEKEK 739
Query: 130 SAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDD 189
+EL+ Q+A G+ +L +R +H D+AARN +V + +K+ D GLARD+ +
Sbjct: 740 KILTQKELISFAYQIARGMEHLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIHSQE 799
Query: 190 YHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAAD-VGA 248
Y+ P++WMAPE+L + Y + SDVWS G+ LWE+ TLG +P + + D +
Sbjct: 800 YYRKTTTGKLPIRWMAPESLEEKFYDSQSDVWSFGVLLWEIMTLGGNPYSSIPTWDNLLE 859
Query: 249 FLNGGYRPSQPHNC 262
L G R QP C
Sbjct: 860 HLKKGKRLEQPPLC 873
>UniRef50_O76385 Cluster: Putative uncharacterized protein; n=3;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 903
Score = 114 bits (274), Expect = 3e-24
Identities = 54/130 (41%), Positives = 75/130 (57%)
Query: 135 RELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLG 194
++L+ Q++ GL YL + FVH DVAARN +V E K+ D GL R ++ D
Sbjct: 685 KQLLQFAVQISYGLEYLSQKGFVHRDVAARNVLVHEGTACKIGDFGLCRYIYADQSQYKS 744
Query: 195 DNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGY 254
P+KWM+PE + ++S SD+WS GI L+E+ TLG SP + DV FL GG
Sbjct: 745 KGGKLPLKWMSPEAIRHYEFSIKSDIWSFGILLFEVITLGGSPYPGMPPEDVLPFLEGGG 804
Query: 255 RPSQPHNCPD 264
R +P NCP+
Sbjct: 805 RIEKPDNCPE 814
>UniRef50_P29317 Cluster: Ephrin type-A receptor 2 precursor; n=32;
Euteleostomi|Rep: Ephrin type-A receptor 2 precursor -
Homo sapiens (Human)
Length = 976
Score = 114 bits (274), Expect = 3e-24
Identities = 79/257 (30%), Positives = 124/257 (48%), Gaps = 11/257 (4%)
Query: 15 DPAEQLRVLTTS--RSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMV--KTXXXXXXXX 70
DP + + TT S + + +I G FG +YKG+ K +EV V KT
Sbjct: 596 DPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEK 655
Query: 71 XXXXXXXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQS 130
E + H N++ ++ KP++I + L +FL + G+ S
Sbjct: 656 QRVDFLGEAGIMGQFSHHNIIRLEGVISKY--KPMMIITEYMENGALDKFLRE-KDGEFS 712
Query: 131 APATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDY 190
+LV + +A G+ YL +VH D+AARN +V+ L KV+D GL+R L D
Sbjct: 713 V---LQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPE 769
Query: 191 HCLGDNENR-PVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAF 249
+ + P++W APE + ++++ASDVWS GI +WE+ T G P EL +V
Sbjct: 770 ATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKA 829
Query: 250 LNGGYRPSQPHNCPDEL 266
+N G+R P +CP +
Sbjct: 830 INDGFRLPTPMDCPSAI 846
>UniRef50_Q1HTP2 Cluster: Tyrosine-protein kinase receptor; n=4;
Percomorpha|Rep: Tyrosine-protein kinase receptor -
Haplochromis burtoni (Burton's mouthbrooder)
Length = 1024
Score = 113 bits (273), Expect = 3e-24
Identities = 57/146 (39%), Positives = 85/146 (58%), Gaps = 1/146 (0%)
Query: 122 SSCRLGQQSAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGL 181
SS L + +L+ Q+ + +L ++ VH D+AARN +V E +KV D GL
Sbjct: 731 SSLLLSDSPLLSLNDLISFSYQIVQAMDFLSSRKCVHRDLAARNILVCEGKLVKVCDFGL 790
Query: 182 ARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAEL 241
ARDL D + N P+KWM+PE++ QN YS+ SDVWS G+ LWE+ +LG SP +L
Sbjct: 791 ARDLLKDQDYIARGNSFLPLKWMSPESIFQNIYSSQSDVWSYGVLLWEIFSLGCSPYPDL 850
Query: 242 D-AADVGAFLNGGYRPSQPHNCPDEL 266
+ + L GYR S+P + P+++
Sbjct: 851 PMTQEFYSALKRGYRMSRPDHAPEDM 876
>UniRef50_A7S4Y9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 277
Score = 113 bits (273), Expect = 3e-24
Identities = 56/185 (30%), Positives = 99/185 (53%), Gaps = 3/185 (1%)
Query: 82 LYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLG 141
L + H+NV++ + C + ++ C +LK+FL SC +S + + +
Sbjct: 62 LVNMEHSNVVSLLGVCRDSEPFYMIFECF--EKGDLKQFLLSCNDNGRSTLTSSHKLTMC 119
Query: 142 AQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPV 201
+ + G+SYL +FVH D+AARNC+V + L++K+ L+ DL+ +Y+ +N P+
Sbjct: 120 SNIVSGMSYLAANKFVHKDLAARNCMVTKDLQVKIGFLNLSYDLYNAEYYRF-NNILIPL 178
Query: 202 KWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHN 261
+WM E + + ++ SDVWS G+ WE+ +LG P + +V + R +P N
Sbjct: 179 RWMPSEAIFHDDFTEKSDVWSFGVLAWEIYSLGQIPYTDRSDEEVLKCVKDDLRLPKPDN 238
Query: 262 CPDEL 266
CPD +
Sbjct: 239 CPDNM 243
>UniRef50_P42685 Cluster: Tyrosine-protein kinase FRK; n=27;
Fungi/Metazoa group|Rep: Tyrosine-protein kinase FRK -
Homo sapiens (Human)
Length = 505
Score = 113 bits (273), Expect = 3e-24
Identities = 78/242 (32%), Positives = 119/242 (49%), Gaps = 14/242 (5%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLV 86
R++I+L + G FG +++G++ V VKT + ++ L
Sbjct: 231 RNSIQLLKRLGSGQFGEVWEGLWNNTT---PVAVKTLKPGSMDPNDFLREAQIMK--NLR 285
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVAC 146
H ++ A C E P+ I +L+ +L + S + VD+ AQVA
Sbjct: 286 HPKLIQLYAVCTLE--DPIYIITELMRHGSLQEYLQN---DTGSKIHLTQQVDMAAQVAS 340
Query: 147 GLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENR---PVKW 203
G++YL + ++H D+AARN +V E KV D GLAR +F D + ++ + PVKW
Sbjct: 341 GMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLAR-VFKVDNEDIYESRHEIKLPVKW 399
Query: 204 MAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCP 263
APE + N++S SDVWS GI L+E+ T G P + + A V L YR QP NCP
Sbjct: 400 TAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCP 459
Query: 264 DE 265
+
Sbjct: 460 QQ 461
>UniRef50_A7SFD8 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 229
Score = 113 bits (272), Expect = 4e-24
Identities = 64/165 (38%), Positives = 95/165 (57%), Gaps = 6/165 (3%)
Query: 104 PLLIYCCPSHSSNLKRFLSSCRL--GQQSAPA--TR-ELVDLGAQVACGLSYLHVQRFVH 158
P++I NL+ +L + RL G++ TR +L+ + +A G+ YLH FVH
Sbjct: 47 PIMIVLEHMSLGNLRNYLLNLRLKYGKEVVLCLDTRSQLLGMIRDIAAGMQYLHSLGFVH 106
Query: 159 ADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTAS 218
D+AARN ++D + K+ D G++RDL DY+ PVKW APE + +YS+AS
Sbjct: 107 RDLAARNILLDSDMICKIGDFGMSRDLMICDYYT-SRGGRIPVKWTAPEAINYGRYSSAS 165
Query: 219 DVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCP 263
DVWS G+ L+E+ +LG P A LD +V ++ GYR P +CP
Sbjct: 166 DVWSYGVLLFEIWSLGDKPYANLDNNEVVEAVSRGYRLPPPDHCP 210
>UniRef50_Q8MY85 Cluster: Fibroblast growth factor receptor 2
precursor; n=3; Dugesia japonica|Rep: Fibroblast growth
factor receptor 2 precursor - Dugesia japonica
(Planarian)
Length = 887
Score = 113 bits (272), Expect = 4e-24
Identities = 75/257 (29%), Positives = 125/257 (48%), Gaps = 21/257 (8%)
Query: 26 SRSNIRLEILIHEGTFGRIYKGV---FKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRL 82
SR ++ + I EG FG +Y + F + EV +KT E L +
Sbjct: 581 SRDSLIIGSKIGEGAFGIVYSALVKSFSENSASVEVAIKTLHTSFGDQDVINLIQE-LEM 639
Query: 83 YGLV--HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFL----SSCRLGQ---QSAPA 133
++ H ++++ AC + P ++ H NL+ FL S ++G+
Sbjct: 640 MKIIGRHRHIISLYGACIDNGH-PYMVIELAKHG-NLRDFLRAQRSQSKVGEIQNSGGLV 697
Query: 134 TR----ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDD 189
TR + + ++A G+ YL ++ +H D+AARN +VD+ + +K+ D GL R + ++
Sbjct: 698 TRLTVTDFLRFSIEIAEGMEYLSSRKIIHRDLAARNVLVDQYVEMKIADFGLTRIV--EN 755
Query: 190 YHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAF 249
Y+ + P+KWMAPE LL Y+ SDVWS GI LWE+ T+G +P + + +
Sbjct: 756 YYRKTTDGRLPIKWMAPECLLDRVYTVKSDVWSYGIVLWEIFTMGQTPYPTIQSDGMHQA 815
Query: 250 LNGGYRPSQPHNCPDEL 266
L G R +P DE+
Sbjct: 816 LRNGIRNEKPALASDEM 832
>UniRef50_Q4H3M5 Cluster: Ephrin receptor; n=1; Ciona
intestinalis|Rep: Ephrin receptor - Ciona intestinalis
(Transparent sea squirt)
Length = 1002
Score = 113 bits (271), Expect = 6e-24
Identities = 75/266 (28%), Positives = 126/266 (47%), Gaps = 11/266 (4%)
Query: 1 MNASGQTVTKDRVTDPAEQLRVLTTS--RSNIRLEILIHEGTFGRIYKGVFKKGDVYEEV 58
+ +G+T R DP ++ + T ++ I+++ +I G FG + +G G V
Sbjct: 586 LQTAGRTYVDYR--DPHNGVKEIATEIDQTRIKIDSVIGRGEFGEVCRGKMLTGKTTTSV 643
Query: 59 MVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLK 118
VK E + N++ + ++ ++I H S L
Sbjct: 644 AVKRLKHGASLIDHTNFLREACTMAQFKDPNIIQ-LKGVVTKSIPAMIITEFMEHGS-LD 701
Query: 119 RFLSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTD 178
+FL + R GQ P +L+++ +A G+ YL ++VH D+AARN +V+ +L KV+D
Sbjct: 702 KFLQA-RSGQ---PTVLQLLEMLRGIASGMKYLSSMKYVHRDLAARNILVNSQLVCKVSD 757
Query: 179 NGLARDLFPDDYHCLGDNENR-PVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSP 237
GL+R L D + ++W APE++ Q+++ASDVWS GI +WE+ + G P
Sbjct: 758 FGLSRTLENDPQATYTTQGGKIALRWTAPESIRCRQFTSASDVWSYGIVMWEVMSYGEKP 817
Query: 238 LAELDAADVGAFLNGGYRPSQPHNCP 263
++ V L GYR P CP
Sbjct: 818 YWDMSNEVVTEVLEDGYRLPSPEGCP 843
>UniRef50_Q8NFA8 Cluster: Transmembrane receptor PTK7-2; n=18;
Euteleostomi|Rep: Transmembrane receptor PTK7-2 - Homo
sapiens (Human)
Length = 1030
Score = 113 bits (271), Expect = 6e-24
Identities = 69/191 (36%), Positives = 104/191 (54%), Gaps = 5/191 (2%)
Query: 80 LRLYG-LVHANVLTPMAACAE-EARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAP-ATRE 136
L ++G L HANV+ + C E E +L Y R S +S P +T++
Sbjct: 807 LEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQ 866
Query: 137 LVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDN 196
V L QVA G+ +L RFVH D+AARNC+V + ++KV+ GL++D++ +Y+
Sbjct: 867 KVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF-RQ 925
Query: 197 ENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGG-YR 255
P++WM+PE +L+ +ST SDVW+ G+ +WE+ T G P +V A L G R
Sbjct: 926 AWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKAR 985
Query: 256 PSQPHNCPDEL 266
QP CP +L
Sbjct: 986 LPQPEGCPSKL 996
>UniRef50_Q13308 Cluster: Tyrosine-protein kinase-like 7 precursor;
n=29; Tetrapoda|Rep: Tyrosine-protein kinase-like 7
precursor - Homo sapiens (Human)
Length = 1070
Score = 113 bits (271), Expect = 6e-24
Identities = 69/191 (36%), Positives = 104/191 (54%), Gaps = 5/191 (2%)
Query: 80 LRLYG-LVHANVLTPMAACAE-EARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAP-ATRE 136
L ++G L HANV+ + C E E +L Y R S +S P +T++
Sbjct: 847 LEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQ 906
Query: 137 LVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDN 196
V L QVA G+ +L RFVH D+AARNC+V + ++KV+ GL++D++ +Y+
Sbjct: 907 KVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF-RQ 965
Query: 197 ENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGG-YR 255
P++WM+PE +L+ +ST SDVW+ G+ +WE+ T G P +V A L G R
Sbjct: 966 AWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKAR 1025
Query: 256 PSQPHNCPDEL 266
QP CP +L
Sbjct: 1026 LPQPEGCPSKL 1036
>UniRef50_P21709 Cluster: Ephrin type-A receptor 1 precursor; n=19;
Mammalia|Rep: Ephrin type-A receptor 1 precursor - Homo
sapiens (Human)
Length = 976
Score = 113 bits (271), Expect = 6e-24
Identities = 74/240 (30%), Positives = 113/240 (47%), Gaps = 11/240 (4%)
Query: 30 IRLEILIHEGTFGRIYKGVFK-KGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHA 88
+ ++ +I EG FG +Y+G + + V +KT E + H
Sbjct: 624 LMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHP 683
Query: 89 NVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGL 148
++L + RKP++I + L FL Q P +LV + +A G+
Sbjct: 684 HILHLEGVVTK--RKPIMIITEFMENGALDAFLRERE--DQLVPG--QLVAMLQGIASGM 737
Query: 149 SYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLAR--DLFPDDYHCLGDNENRPVKWMAP 206
+YL +VH D+AARN +V++ L KV+D GL R D F Y G P++W AP
Sbjct: 738 NYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKI--PIRWTAP 795
Query: 207 ETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
E + ++TASDVWS GI +WE+ + G P E+ +V + GYR P +CP L
Sbjct: 796 EAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPL 855
>UniRef50_Q09147 Cluster: Fibroblast growth factor receptor homolog
2 precursor; n=4; Coelomata|Rep: Fibroblast growth
factor receptor homolog 2 precursor - Drosophila
melanogaster (Fruit fly)
Length = 1052
Score = 112 bits (270), Expect = 8e-24
Identities = 74/261 (28%), Positives = 123/261 (47%), Gaps = 27/261 (10%)
Query: 27 RSNIRLEILIHEGTFGRIY----KGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRL 82
R + L ++ EG FGR+ +G+ + + E ++ + +
Sbjct: 709 RQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEV 768
Query: 83 YGLV--HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLG--QQSAPAT---- 134
++ H N++ + C++ PL + + NLK FL R G Q+ + +
Sbjct: 769 MKMIGKHINIINLLGCCSQGG--PLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLD 826
Query: 135 ------------RELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLA 182
+EL Q+A G+ YL +R +H D+AARN +V + +K+ D GLA
Sbjct: 827 DKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLA 886
Query: 183 RDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAE-L 241
RD+ +Y+ N P+KWMAPE+L + +Y + SDVWS G+ LWE+ T G P L
Sbjct: 887 RDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHIL 946
Query: 242 DAADVGAFLNGGYRPSQPHNC 262
A ++ ++L G R +P C
Sbjct: 947 SAEELYSYLITGQRMEKPAKC 967
>UniRef50_UPI0000D5603D Cluster: PREDICTED: similar to Insulin
receptor precursor (IR); n=1; Tribolium castaneum|Rep:
PREDICTED: similar to Insulin receptor precursor (IR) -
Tribolium castaneum
Length = 1293
Score = 112 bits (269), Expect = 1e-23
Identities = 69/248 (27%), Positives = 121/248 (48%), Gaps = 10/248 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDV-YEEVMVKTXXXXXXXXXXXXXXXEGLRLYGL 85
R+++ + + EG FG +Y G D + V VKT E +
Sbjct: 898 RNSVVINRKLGEGAFGTVYGGEANFPDKGWVAVAVKTLKVGSSTEEKLDFLSEAEVMKRF 957
Query: 86 VHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCR-------LGQQSAPATRELV 138
H N++ + C +E +P+ +LK FL + R + + ++++L
Sbjct: 958 DHKNIIKLLGVCTKE--EPIYTIMEFMLYGDLKTFLLARRHLVNDKTIEESDEISSKKLT 1015
Query: 139 DLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNEN 198
+ VA GLSYL ++VH DVA+RNC+++ + +K+ D G+ R +F +DY+
Sbjct: 1016 MMALDVARGLSYLAQLKYVHRDVASRNCLINAQRIVKLADFGMTRPMFENDYYKFTRKGM 1075
Query: 199 RPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQ 258
PV+WM+PE+L ++ +SDVWS G+ L+E+ T GS P + +V ++ G+ +
Sbjct: 1076 LPVRWMSPESLALGVFTPSSDVWSYGVLLYEIITFGSFPYQGMTNGEVLEYVKNGHTVTI 1135
Query: 259 PHNCPDEL 266
P +L
Sbjct: 1136 PQGVKTQL 1143
>UniRef50_Q9Y1Y2 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 743
Score = 112 bits (269), Expect = 1e-23
Identities = 76/244 (31%), Positives = 118/244 (48%), Gaps = 9/244 (3%)
Query: 26 SRSNIRLEILIHEGTFGRIYKGVFKKGDVYE-EVMVKTXXXXXXXXXXXXXXXEGLRLYG 84
S ++ L + +G FG + KG++K D + EV VKT E +
Sbjct: 461 SEHDLHLGAELGQGEFGSVLKGLYKGADGKKIEVAVKTLRLDSQGHGEKEFAREAGIMVT 520
Query: 85 LVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQV 144
L H ++ + KP+++ L +L + Q P L A++
Sbjct: 521 LNHPCIVKLIGITNG---KPMMMVQELISMGALVDYLYERK---QPIPDVLTLKLWAAEI 574
Query: 145 ACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPD-DYHCLGDNENRPVKW 203
A G+ YL +RFVH D+AARN +V ++K++D GL+R + + DY+ PVKW
Sbjct: 575 ASGMMYLETKRFVHRDLAARNILVQSMKQVKISDFGLSRAVGANSDYYKASQGGRWPVKW 634
Query: 204 MAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADV-GAFLNGGYRPSQPHNC 262
APE++ +S ASDVWS GITLWE+ + G +P ++ A+V N YR P +C
Sbjct: 635 YAPESINFGTFSHASDVWSYGITLWEMFSFGDAPYGDMTGAEVLDRVENLNYRLECPRDC 694
Query: 263 PDEL 266
P +
Sbjct: 695 PSSI 698
>UniRef50_Q9Y1X8 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 1193
Score = 112 bits (269), Expect = 1e-23
Identities = 71/254 (27%), Positives = 119/254 (46%), Gaps = 10/254 (3%)
Query: 16 PAEQLRVLTTSRSNIRLEILIHEGTFGRIYKGVFK-KGD--VYEEVMVKTXXXXXXXXXX 72
P + R++ T + + ++ G FG +YKG ++ +GD YE +
Sbjct: 827 PPDATRLIITPETALEQGQVLGSGAFGTVYKGHWRPEGDPNCYEVAIKVLKEETATPQSQ 886
Query: 73 XXXXXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAP 132
EG + + H NV+ C ++ +LI + L LS + Q +
Sbjct: 887 TELLREGAVMATMDHINVVRLYCVCM--GKQMMLI----TEFVRLGSLLSYLKNNQATLD 940
Query: 133 ATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHC 192
A +++ Q+A G++YL +R VH D+AARN +V +K+TD GL R + + H
Sbjct: 941 AY-SMLNFSRQIADGMAYLEEKRMVHRDLAARNVLVHTPQLVKITDFGLTRIIDVGESHY 999
Query: 193 LGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNG 252
P++WMAPE++ +Y+ SDVWS G+T+WE+ T G P + +V +
Sbjct: 1000 KATGGMVPLRWMAPESIFLFEYTHKSDVWSFGVTIWEILTFGRLPYKGKNGKEVSQLVKN 1059
Query: 253 GYRPSQPHNCPDEL 266
G + +P C L
Sbjct: 1060 GQQLERPATCDANL 1073
>UniRef50_Q9BL77 Cluster: C-terminal src kinase protein 1; n=2;
Caenorhabditis|Rep: C-terminal src kinase protein 1 -
Caenorhabditis elegans
Length = 539
Score = 112 bits (269), Expect = 1e-23
Identities = 71/244 (29%), Positives = 112/244 (45%), Gaps = 12/244 (4%)
Query: 23 LTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRL 82
L S ++I + I G FG + G +K V +V + E +
Sbjct: 276 LVISSNDIDVGDTIGHGEFGDVRLGTYKNRKVALKVSKR-----HGNGMLDSLLDEAKFM 330
Query: 83 YGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGA 142
GL H N++T + ++ +Y + +N + R + A R+L+
Sbjct: 331 VGLSHPNLVTLVGVVLDDVN----VYMITEYMAN-GNLIDLLRSRGRHALERRQLMMFAM 385
Query: 143 QVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVK 202
+ G+ YL ++ VH D+AARN ++D+ L KV+D GLA+ + P+K
Sbjct: 386 DICQGMCYLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSHDSASGKF--PIK 443
Query: 203 WMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNC 262
W APE L +Q++T SDVWS GI LWE+ + G P + DV ++ GYR P C
Sbjct: 444 WTAPEALRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYIEKGYRMEAPEGC 503
Query: 263 PDEL 266
P E+
Sbjct: 504 PPEI 507
>UniRef50_Q7YZX2 Cluster: Bruton's tyrosine kinase-like protein;
n=1; Suberites domuncula|Rep: Bruton's tyrosine
kinase-like protein - Suberites domuncula (Sponge)
Length = 700
Score = 112 bits (269), Expect = 1e-23
Identities = 71/228 (31%), Positives = 111/228 (48%), Gaps = 11/228 (4%)
Query: 39 GTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMAACA 98
G FGR+ G +K G + +V +K + ++ + H N++ C
Sbjct: 442 GQFGRVVSGKWK-GKI--DVAIKMMREGAMNEDDFIEEAKVMKQFQ--HENLVKLYGVCT 496
Query: 99 EEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQRFVH 158
+ P+ I + L +FL R ++ T ++D+ Q+ + YL F+H
Sbjct: 497 KNG--PIFIVQELMVNGCLLQFL---RQRKELVEKTEIILDMATQICSAMKYLEESGFIH 551
Query: 159 ADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTAS 218
D+AARNC+V E+ +KV D GLAR + D+Y + P+KW APE + ++S+ S
Sbjct: 552 RDLAARNCLVGERNVVKVADFGLARFVVDDEYTA-SEGTKFPIKWAAPEVITHAKFSSKS 610
Query: 219 DVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
DVWS GI LWEL T G +P + V + GYR +P CP E+
Sbjct: 611 DVWSFGILLWELWTGGKTPYPTFTNSQVLDEVLMGYRLDRPKQCPPEV 658
>UniRef50_Q9I9L1 Cluster: Arg protein-tyrosine kinase; n=12;
Tetrapoda|Rep: Arg protein-tyrosine kinase - Xenopus
laevis (African clawed frog)
Length = 721
Score = 111 bits (268), Expect = 1e-23
Identities = 52/123 (42%), Positives = 72/123 (58%), Gaps = 1/123 (0%)
Query: 144 VACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKW 203
++ + YL + F+H D+AARNC+V E +KV D GL+R L D + P+KW
Sbjct: 1 ISSAMEYLERKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAKFPIKW 59
Query: 204 MAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCP 263
APE+L N +S SDVW+ G+ LWE+AT G SP +D + V L GYR QP CP
Sbjct: 60 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP 119
Query: 264 DEL 266
++
Sbjct: 120 PKV 122
>UniRef50_Q8JFV0 Cluster: Tyrosine-protein kinase receptor; n=5;
Euteleostomi|Rep: Tyrosine-protein kinase receptor -
Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 1161
Score = 111 bits (268), Expect = 1e-23
Identities = 69/243 (28%), Positives = 109/243 (44%), Gaps = 6/243 (2%)
Query: 27 RSNIRLEILIHEGTFGRIYKG--VFKKGD-VYEEVMVKTXXXXXXXXXXXXXXXEGLRLY 83
R NI L + G FG +Y+G + G+ +V +KT E L +
Sbjct: 563 RKNITLLRALGHGAFGEVYEGQVLGMNGENTAMQVAIKTLPEICSEQDEMDFLMEALIMS 622
Query: 84 GLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQ 143
H N++ + + + +L+ L+ R S+ + EL+ +
Sbjct: 623 KFSHQNIVRCIGVSLQILPRFILLELMTGGDMKSFLRLNRPRTNHSSSLSMLELLHMARD 682
Query: 144 VACGLSYLHVQRFVHADVAARNCVVD---EKLRLKVTDNGLARDLFPDDYHCLGDNENRP 200
+A G YL F+H D+AARNC++ K+ D G+ARD++ Y+ G P
Sbjct: 683 IALGCRYLEENHFIHRDIAARNCLLTCPGPDRVAKIGDFGMARDIYRASYYRKGGRAMLP 742
Query: 201 VKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPH 260
VKWM PE L+ ++ +D WS G+ LWE+ +LG P +V F+ GG R P
Sbjct: 743 VKWMPPEAFLEGIFTCKTDTWSFGVLLWEIFSLGYMPYPCKTNQEVLEFVTGGGRMDPPK 802
Query: 261 NCP 263
+CP
Sbjct: 803 SCP 805
>UniRef50_P04412 Cluster: Epidermal growth factor receptor precursor;
n=129; Endopterygota|Rep: Epidermal growth factor
receptor precursor - Drosophila melanogaster (Fruit fly)
Length = 1426
Score = 111 bits (268), Expect = 1e-23
Identities = 70/226 (30%), Positives = 107/226 (47%), Gaps = 9/226 (3%)
Query: 39 GTFGRIYKGVF-KKGD-VYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMAA 96
G FGR+YKGV+ +G+ V V +K E + H N+L +A
Sbjct: 947 GAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASEEHVNLLKLLAV 1006
Query: 97 CAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQRF 156
C ++ L+ P L L R + ++ L++ Q+A G+SYL +R
Sbjct: 1007 CMS-SQMMLITQLMP-----LGCLLDYVRNNRDKI-GSKALLNWSTQIAKGMSYLEEKRL 1059
Query: 157 VHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYST 216
VH D+AARN +V +K+TD GLA+ L D P+KW+A E + +++
Sbjct: 1060 VHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTS 1119
Query: 217 ASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNC 262
SDVW+ G+T+WEL T G P + A D+ + G + QP C
Sbjct: 1120 KSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEIC 1165
>UniRef50_UPI0000F1D883 Cluster: PREDICTED: hypothetical protein;
n=1; Danio rerio|Rep: PREDICTED: hypothetical protein -
Danio rerio
Length = 1162
Score = 111 bits (267), Expect = 2e-23
Identities = 65/206 (31%), Positives = 100/206 (48%), Gaps = 9/206 (4%)
Query: 39 GTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMAACA 98
G FG++ G G +V+VK E L H +L ++
Sbjct: 26 GWFGKVLLGEVNAGLSTTQVVVKELKASASVQEQMQFLEEVQPYRVLQHPALLQCLSQST 85
Query: 99 EEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQRFVH 158
E L++ CP ++K +L SCR P L + ++A GL YLH ++H
Sbjct: 86 EVTPYLLVMEHCPL--GDVKGYLRSCRAADSVTPDPLILQRMACEIASGLLYLHKHNYIH 143
Query: 159 ADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPE-------TLLQ 211
+D+A RNC++ +L +K+ D GL+ + DDY+ D P++W+APE LL
Sbjct: 144 SDLALRNCLLTSELAVKIGDYGLSHSKYKDDYYVTADQIWVPLRWIAPELIDEVHGNLLV 203
Query: 212 NQYSTASDVWSLGITLWELATLGSSP 237
+ AS+VWSLG+T+WEL LG+ P
Sbjct: 204 VDQTKASNVWSLGVTIWELFELGNQP 229
>UniRef50_UPI0000E47A46 Cluster: PREDICTED: similar to ret protein;
n=2; Strongylocentrotus purpuratus|Rep: PREDICTED:
similar to ret protein - Strongylocentrotus purpuratus
Length = 531
Score = 111 bits (267), Expect = 2e-23
Identities = 74/250 (29%), Positives = 119/250 (47%), Gaps = 12/250 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKG-VFKKGDV--YEEVMVKTXXXXXXXXXXXXXXXEGLRLY 83
RS +++E + G FG +YK F + Y V VK+ E +
Sbjct: 284 RSLLKIEKELGAGQFGIVYKAFAFGLNGIKEYVPVAVKSLRVNATPGMEEDFLNEIKLMI 343
Query: 84 GL-VHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPAT------RE 136
L H N+L + C +P + +L FL CR + +
Sbjct: 344 DLGQHPNILQIIGCCT--VHEPNYLITEYMKYGDLLHFLWKCREDKYRRQDSIFDLTQAN 401
Query: 137 LVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDN 196
+ + Q++ G+ Y+ R+ H D+AARN +V E L +KV+D GLA D++ Y L +
Sbjct: 402 QLQICRQISRGMEYIFKTRYYHGDLAARNVLVGEGLEVKVSDFGLADDIYQSGYKRLAPD 461
Query: 197 ENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRP 256
+ RPVKW++ ET + + SDVWS GI ++E+ TLG P +D ++ + L GYR
Sbjct: 462 KKRPVKWVSLETNTIGRCTIQSDVWSFGIVMYEIYTLGGVPYPGMDGREIISKLQEGYRM 521
Query: 257 SQPHNCPDEL 266
+P CP+++
Sbjct: 522 PKPDQCPEDV 531
>UniRef50_UPI0000D569CE Cluster: PREDICTED: similar to CG10023-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG10023-PA, isoform A - Tribolium castaneum
Length = 1106
Score = 111 bits (267), Expect = 2e-23
Identities = 69/241 (28%), Positives = 113/241 (46%), Gaps = 8/241 (3%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGD-VYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGL 85
R I+L ++ EG FG ++KG +K D V VKT E +
Sbjct: 425 RDQIQLGEILGEGQFGDVHKGTYKAKDGSLIPVAVKTCKREADLNTTEKFLEEAYIMQKF 484
Query: 86 VHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVA 145
H +++ + C+E P+ I + L+ +L + + A L+ Q++
Sbjct: 485 DHQHIIKLIGVCSES---PVWIVMELAKLGELRAYLQNNKDDLDLAT----LLLYAFQLS 537
Query: 146 CGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMA 205
LSYL ++FVH D+AARN +V +K+ D GL+R + D + P+KWM+
Sbjct: 538 TALSYLESKKFVHRDIAARNVLVSSHTSVKLGDFGLSRSMNDDQSYYKASKGKLPIKWMS 597
Query: 206 PETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDE 265
PE++ +++ ASDVW G+ +WE+ G P + +V + G R + P NCP
Sbjct: 598 PESINFRRFTIASDVWMFGVCMWEILMYGIKPFQGVKNNEVLTKIENGERLALPPNCPPR 657
Query: 266 L 266
L
Sbjct: 658 L 658
>UniRef50_Q98TD0 Cluster: Ephrin receptor; n=6; Amniota|Rep: Ephrin
receptor - Gallus gallus (Chicken)
Length = 969
Score = 111 bits (267), Expect = 2e-23
Identities = 72/241 (29%), Positives = 115/241 (47%), Gaps = 8/241 (3%)
Query: 28 SNIRLEILIHEGTFGRIYKGVFK-KGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLV 86
S + +E +I EG FG +Y+G + G V +KT E +
Sbjct: 614 SCVTMENVIGEGEFGEVYRGSLRLPGKERIVVAIKTLKSTYSDSQWWNFLREATIMGQFN 673
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVAC 146
H N++ + R+P++I + L FL ++ +P +LV++ +A
Sbjct: 674 HPNIVHLEGVVTK--RRPMMIITEYMENGALDTFLRENE--EKFSPV--QLVNMLQGIAS 727
Query: 147 GLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENR-PVKWMA 205
G++YL +VH D+AARN +V L+ KV+D GL+R L D + P++W A
Sbjct: 728 GMTYLSEHNYVHRDLAARNILVTRSLQCKVSDFGLSRILENDAEGTYETKGGKIPIRWTA 787
Query: 206 PETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDE 265
PE + +++ASDVWS GI +WE+ + G P + +V L GYR P +CP
Sbjct: 788 PEAIAHRIFTSASDVWSFGIVMWEVLSFGDKPYGNMTNQEVMKSLEDGYRLPPPVDCPSI 847
Query: 266 L 266
L
Sbjct: 848 L 848
>UniRef50_Q8WPV5 Cluster: Tyrosine kinase; n=2; Eumetazoa|Rep:
Tyrosine kinase - Schistosoma mansoni (Blood fluke)
Length = 1264
Score = 111 bits (267), Expect = 2e-23
Identities = 71/231 (30%), Positives = 116/231 (50%), Gaps = 11/231 (4%)
Query: 39 GTFGRIYKGVFKKGDVYE-EVMVKTXX-XXXXXXXXXXXXXEGLRLYGLVHANVLTPMAA 96
G FG + KG+++ E V VKT E + L H +++ +
Sbjct: 897 GNFGHVVKGLYRTPSGQEVPVAVKTLKPNQIANSGEREILAEARTMAQLKHRHIVRLIGV 956
Query: 97 CAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQRF 156
C EE + L++ P N ++L ++ + L +L QVA G++YL +F
Sbjct: 957 CKEE-QFMLVLELAPLGPIN--KYLK-----KRPDVSVHTLTELMHQVALGMAYLESCKF 1008
Query: 157 VHADVAARNCVVDEKLRLKVTDNGLARDL-FPDDYHCLGDNENRPVKWMAPETLLQNQYS 215
VH D+AARN ++ + K++D G+++ L F DY+ P+KW APE + ++
Sbjct: 1009 VHRDLAARNVLLVTRHFAKISDFGMSKALNFGSDYYRAATAGKWPLKWYAPECIYYFRFD 1068
Query: 216 TASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
+ SDVWS GITLWE+ + G P ++ A + A L+ G R S+P CP+ +
Sbjct: 1069 SKSDVWSYGITLWEVYSYGERPYRDMKGAQILAMLDQGLRLSRPSRCPESI 1119
>UniRef50_Q9VBW3 Cluster: Tyrosine kinase receptor Cad96Ca
precursor; n=2; Diptera|Rep: Tyrosine kinase receptor
Cad96Ca precursor - Drosophila melanogaster (Fruit fly)
Length = 773
Score = 111 bits (267), Expect = 2e-23
Identities = 62/188 (32%), Positives = 95/188 (50%), Gaps = 10/188 (5%)
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRL--------GQQSAPATRELV 138
H NV+ + C + + P + + L+ +L S R G+ + + +L
Sbjct: 531 HINVVHLLGCCTD--KDPTFVILEYVNRGKLQTYLRSSRAERHYGNTHGKSNVLTSCDLT 588
Query: 139 DLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNEN 198
QVA G+ YL + +H D+AARN ++ + KV D G ARD+ +
Sbjct: 589 SFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGK 648
Query: 199 RPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQ 258
P++WMA E+L N +S SD+WS GI +WE+ TLGS+P + AADV + GYR +
Sbjct: 649 LPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEK 708
Query: 259 PHNCPDEL 266
P +C EL
Sbjct: 709 PEHCRREL 716
>UniRef50_UPI0000D57178 Cluster: PREDICTED: similar to CG14396-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG14396-PA, isoform A - Tribolium castaneum
Length = 1065
Score = 111 bits (266), Expect = 2e-23
Identities = 52/132 (39%), Positives = 77/132 (58%)
Query: 135 RELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLG 194
+E++ Q+ G++YL + VH D+AARN ++ K++D GL RD++ DD +
Sbjct: 872 KEILSFAWQICKGMAYLSEIKLVHRDLAARNVLLAADQICKISDFGLTRDIYEDDAYFKR 931
Query: 195 DNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGY 254
PVKWMAPE+L + Y+ SDVWS GI +WEL TLG++P + ++ L GY
Sbjct: 932 SKGRVPVKWMAPESLSDHIYTNKSDVWSFGILVWELVTLGATPYPGIAVQNLFHLLRQGY 991
Query: 255 RPSQPHNCPDEL 266
R +P NC L
Sbjct: 992 RMERPDNCSPTL 1003
>UniRef50_Q95ZV7 Cluster: Putative uncharacterized protein; n=3;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 797
Score = 111 bits (266), Expect = 2e-23
Identities = 67/196 (34%), Positives = 107/196 (54%), Gaps = 16/196 (8%)
Query: 80 LRLYG-LVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELV 138
+R+ G L H NV+ + C +KP+L + +LK ++ + T + +
Sbjct: 571 IRVLGSLKHPNVVEVVGVCT--IQKPILCIMEYMENGDLKSYIL-----KNPTIQTSQCI 623
Query: 139 DLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNEN 198
+ Q+A GL+YL FVH D+AARNC+VD + +K+ D G+AR L+ +Y+ +
Sbjct: 624 SICTQLAAGLAYLESCNFVHRDIAARNCLVDGEGNVKIADFGMARSLYSQEYYKVEGKFV 683
Query: 199 RPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGS-SPLAELDAADVGAFL-----NG 252
P++WMA E LL ++STASDVW G+T+WE+ +L S P +++ DV L G
Sbjct: 684 LPIRWMAWEALLLGKFSTASDVWGFGVTMWEIFSLCSEKPYSDMTDDDVVENLQSMSSTG 743
Query: 253 GYRP--SQPHNCPDEL 266
+ S+P CP +L
Sbjct: 744 SLKQVLSRPRMCPSKL 759
>UniRef50_Q9V6K3 Cluster: Tyrosine-protein kinase transmembrane
receptor Ror2 precursor; n=2; Sophophora|Rep:
Tyrosine-protein kinase transmembrane receptor Ror2
precursor - Drosophila melanogaster (Fruit fly)
Length = 724
Score = 111 bits (266), Expect = 2e-23
Identities = 77/269 (28%), Positives = 124/269 (46%), Gaps = 17/269 (6%)
Query: 8 VTKDRVTDPAEQLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVYEE----VMVKTX 63
V+ + T P +L L R +I + +G FGR+++ G V ++ V VK
Sbjct: 419 VSDAKGTKPNARLEKLEYPRGDIVYVRSLGQGAFGRVFQAR-APGLVPDQEDLLVAVKML 477
Query: 64 XXXXXXXXXXXXXXEGLRLYGLVHANVLTPMAACAEEARKPLLI-YCCPSHSSNLKRFLS 122
E L H N++ + CA LL Y P +L FL
Sbjct: 478 KDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPG---DLSEFLR 534
Query: 123 SCR-LGQQSAPATREL-------VDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRL 174
+C AP L + + A +A G+ YL ++FVH D+A RNC+++E + +
Sbjct: 535 ACSPYATHQAPTQDRLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAV 594
Query: 175 KVTDNGLARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLG 234
K+ D GL+ ++ DY+ +N+ P++WM E++L N++S SDVW+ GI LWE+ +
Sbjct: 595 KIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFA 654
Query: 235 SSPLAELDAADVGAFLNGGYRPSQPHNCP 263
P L +V ++ G P N P
Sbjct: 655 LQPYFGLTHEEVIKYIKEGNVLGCPDNTP 683
>UniRef50_P24348 Cluster: Receptor tyrosine-protein kinase let-23
precursor; n=3; Caenorhabditis|Rep: Receptor
tyrosine-protein kinase let-23 precursor - Caenorhabditis
elegans
Length = 1323
Score = 111 bits (266), Expect = 2e-23
Identities = 74/247 (29%), Positives = 120/247 (48%), Gaps = 9/247 (3%)
Query: 22 VLTTSRSNIRLEILIHEGTFGRIYKGVF-KKGDVYEEVMVKTXXXXXXXXXXXXXXXEGL 80
++ +S +L+ + G FG ++ G++ K ++ V E
Sbjct: 877 LIPSSELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEAT 936
Query: 81 RLYGLVHANVLTPMAACA-EEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVD 139
++ L H N+L + C ++ K + IY NL+ FL +L +++ A RE V
Sbjct: 937 NMFRLRHDNLLKIIGFCMHDDGLKIVTIY---RPLGNLQNFL---KLHKENLGA-REQVL 989
Query: 140 LGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENR 199
Q+A G+ YL QR VH D+A RN +V + +++TD GL++ L D +
Sbjct: 990 YCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKV 1049
Query: 200 PVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQP 259
+KW+A E ++ Y+ ASDVW+ G+T WE+ T G SP + + FL G R SQP
Sbjct: 1050 AIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQP 1109
Query: 260 HNCPDEL 266
NC +L
Sbjct: 1110 PNCSQDL 1116
>UniRef50_P08631 Cluster: Tyrosine-protein kinase HCK; n=32;
Euteleostomi|Rep: Tyrosine-protein kinase HCK - Homo
sapiens (Human)
Length = 526
Score = 111 bits (266), Expect = 2e-23
Identities = 71/240 (29%), Positives = 114/240 (47%), Gaps = 12/240 (5%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLV 86
R +++LE + G FG ++ + K + +V VKT ++ L
Sbjct: 259 RESLKLEKKLGAGQFGEVWMATYNK---HTKVAVKTMKPGSMSVEAFLAEANVMKT--LQ 313
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVAC 146
H ++ A +E P+ I +L FL S +Q P +L+D AQ+A
Sbjct: 314 HDKLVKLHAVVTKE---PIYIITEFMAKGSLLDFLKSDEGSKQPLP---KLIDFSAQIAE 367
Query: 147 GLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAP 206
G++++ + ++H D+ A N +V L K+ D GLAR + D+ + + P+KW AP
Sbjct: 368 GMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLAR-VIEDNEYTAREGAKFPIKWTAP 426
Query: 207 ETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
E + ++ SDVWS GI L E+ T G P + +V L GYR +P NCP+EL
Sbjct: 427 EAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEEL 486
>UniRef50_UPI00015A3FB5 Cluster: hypothetical protein LOC553690;
n=3; Danio rerio|Rep: hypothetical protein LOC553690 -
Danio rerio
Length = 981
Score = 110 bits (265), Expect = 3e-23
Identities = 67/247 (27%), Positives = 121/247 (48%), Gaps = 11/247 (4%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYG-L 85
RSN+ + +G FG + K + EE +V ++ L
Sbjct: 705 RSNLHTITTLGKGEFGEVLLAKAKAAEDEEETVVLVKSLQTRDEQMQMDFRRECDMFAKL 764
Query: 86 VHANVLTPMAACAE-EARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAP----ATRELVDL 140
H+NV + C E E ++ Y + +LK++L + + +T++ V +
Sbjct: 765 SHSNVARLLGICREVEPHYMIMEY---TDMGDLKQYLRVSKSKDEKVKVQPLSTKQKVSV 821
Query: 141 GAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRP 200
QVA G+ +L QRFVH D+AARNC++ K ++KV+ GL++D++ +Y+ + P
Sbjct: 822 CLQVARGMEHLSNQRFVHKDLAARNCLISSKRQIKVSSLGLSKDVYSSEYYHYRQS-YIP 880
Query: 201 VKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAEL-DAADVGAFLNGGYRPSQP 259
++W+ E + ++ +ST +DVWS + +WE+ + G P A+L D + A +G + P
Sbjct: 881 LRWLPSEAVFEDDFSTKTDVWSFAVLMWEVFSFGEMPYADLADDKVLEALQDGKLKLCPP 940
Query: 260 HNCPDEL 266
CP +
Sbjct: 941 QGCPSRV 947
>UniRef50_Q4SII9 Cluster: Chromosome 5 SCAF14581, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 5
SCAF14581, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 921
Score = 110 bits (265), Expect = 3e-23
Identities = 64/181 (35%), Positives = 94/181 (51%), Gaps = 7/181 (3%)
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCR-LGQQSAPATRELVDLGAQVA 145
H NV+ + C + ++P+ I S FL+ R G+ P + LV + VA
Sbjct: 716 HPNVVKLIGVCTQ--KQPIYIVMELIQGSG--DFLTFLRNQGRDLKP--KALVKMAENVA 769
Query: 146 CGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMA 205
G++YL ++ +H D+AARNC+V E +K++D G++R Y G P+KW A
Sbjct: 770 SGMAYLESKKCIHRDLAARNCLVAENNSVKISDFGMSRQDDDGVYLAEGGLRQIPIKWTA 829
Query: 206 PETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDE 265
PE L +Y+T SDVWS GI LWE +LG +P + + GYR PH CP E
Sbjct: 830 PEALNYGRYTTQSDVWSFGILLWETFSLGLTPYMSMSNQQTRDEVEKGYRMPAPHACPVE 889
Query: 266 L 266
+
Sbjct: 890 I 890
>UniRef50_Q8T6F8 Cluster: SRC-1; n=3; Caenorhabditis|Rep: SRC-1 -
Caenorhabditis elegans
Length = 533
Score = 110 bits (265), Expect = 3e-23
Identities = 74/244 (30%), Positives = 119/244 (48%), Gaps = 15/244 (6%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLV 86
R+ + L+ + +G FG ++ G ++ G V EV +KT + ++
Sbjct: 259 RNQLHLKRKLGDGNFGEVWYGKWR-GIV--EVAIKTMKPGTMSPEAFLQEAQIMKQCD-- 313
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVAC 146
H N++ A C E +P I + +L ++L + S + LVD+ AQ+A
Sbjct: 314 HPNLVKLYAVCTRE--EPFYIITEYMINGSLLQYLRT----DGSTLGIQALVDMAAQIAN 367
Query: 147 GLSYLHVQRFVHADVAARNCVVDEKLR----LKVTDNGLARDLFPDDYHCLGDNENRPVK 202
G+ YL ++ VH D+AARN +V +K+ +KV D GLAR L +D + P+K
Sbjct: 368 GMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIK 427
Query: 203 WMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNC 262
W APE ++ SDVWS GI L+E+ T G P + +V + GYR P C
Sbjct: 428 WTAPEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRGC 487
Query: 263 PDEL 266
P+++
Sbjct: 488 PEQI 491
>UniRef50_P42686 Cluster: Tyrosine-protein kinase isoform SRK1;
n=11; Metazoa|Rep: Tyrosine-protein kinase isoform SRK1
- Spongilla lacustris (Freshwater sponge)
Length = 505
Score = 110 bits (264), Expect = 4e-23
Identities = 75/239 (31%), Positives = 114/239 (47%), Gaps = 12/239 (5%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLV 86
++ I+L + G FG +++G++ G V VKT E + L
Sbjct: 237 KTQIKLLRRLGAGQFGEVWEGLWN-GTT--SVAVKTLKPGTMSVEEFLQ--EASIMKRLR 291
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVAC 146
H ++ A C +E +P+ I +L +L G+ +LVD+ AQVA
Sbjct: 292 HPKLIQLYAVCTKE--EPIYIVTELMKYGSLLEYLR----GEDGVLKIEQLVDVAAQVAS 345
Query: 147 GLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAP 206
G+SYL Q ++H D+AARN +V E KV D GLAR + + Y P+KW AP
Sbjct: 346 GMSYLEQQNYIHRDLAARNILVGEHGICKVADFGLARVIDEEIYEA-HTGAKFPIKWTAP 404
Query: 207 ETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDE 265
E + N+++ SDVWS G+ L+E+ T G P + +V + YR P NCP +
Sbjct: 405 EAAMYNRFTIKSDVWSFGVVLYEIITYGRFPYPGMTNPEVLEKIQQNYRMPCPANCPKQ 463
>UniRef50_P21860 Cluster: Receptor tyrosine-protein kinase erbB-3
precursor; n=41; cellular organisms|Rep: Receptor
tyrosine-protein kinase erbB-3 precursor - Homo sapiens
(Human)
Length = 1342
Score = 110 bits (264), Expect = 4e-23
Identities = 77/253 (30%), Positives = 123/253 (48%), Gaps = 12/253 (4%)
Query: 15 DPAEQL-RVLTT--SRSNIRLEILIHEGTFGRIYKGVF-KKGDVYE-EVMVKTXXXXXXX 69
DP+E+ +VL + +R ++ G FG ++KGV+ +G+ + V +K
Sbjct: 691 DPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGR 750
Query: 70 XXXXXXXXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQ 129
L + L HA+++ + C + + + Y L L R +
Sbjct: 751 QSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYL------PLGSLLDHVRQ-HR 803
Query: 130 SAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDD 189
A + L++ G Q+A G+ YL VH ++AARN ++ +++V D G+A L PDD
Sbjct: 804 GALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDD 863
Query: 190 YHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAF 249
L P+KWMA E++ +Y+ SDVWS G+T+WEL T G+ P A L A+V
Sbjct: 864 KQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDL 923
Query: 250 LNGGYRPSQPHNC 262
L G R +QP C
Sbjct: 924 LEKGERLAQPQIC 936
>UniRef50_Q4L0H7 Cluster: Insulin receptor tyrosine kinase; n=2;
Schistosoma|Rep: Insulin receptor tyrosine kinase -
Schistosoma mansoni (Blood fluke)
Length = 1736
Score = 109 bits (263), Expect = 5e-23
Identities = 48/125 (38%), Positives = 76/125 (60%), Gaps = 3/125 (2%)
Query: 143 QVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVK 202
Q+A G++YL +++VH D+AARNC+VD L +K+ D GL RD++ +Y+ + P++
Sbjct: 1396 QIADGMAYLSAKQYVHRDLAARNCLVDSSLTVKIGDFGLCRDVYGHNYYHKTSHAKLPIR 1455
Query: 203 WMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGG---YRPSQP 259
WMAPE+L ++T SDVWS G+ LWE+ T+ P + +V ++ G P
Sbjct: 1456 WMAPESLQTAYFTTQSDVWSYGVVLWEIVTMACLPYRSMSHEEVVKYVLSGKTLLSNGSP 1515
Query: 260 HNCPD 264
NCP+
Sbjct: 1516 TNCPE 1520
>UniRef50_A7SAX2 Cluster: Predicted protein; n=3; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 315
Score = 109 bits (263), Expect = 5e-23
Identities = 56/128 (43%), Positives = 77/128 (60%), Gaps = 2/128 (1%)
Query: 134 TRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCL 193
+++LV +A G+++L + VH D+AARN +V E K++D GLARD+ D Y
Sbjct: 149 SKDLVKFAWMIADGMAFLAANKCVHRDLAARNVLVGEHNTCKISDLGLARDVSQDIY-TR 207
Query: 194 GDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGG 253
+ PVKWM PE+LL Q S+ASDVWS GI LWE+ T+G SP + + + L G
Sbjct: 208 TSSARLPVKWMPPESLLYGQSSSASDVWSYGIVLWEIFTIGDSPYPGVKSKGIPRMLREG 267
Query: 254 YR-PSQPH 260
YR P PH
Sbjct: 268 YRMPKPPH 275
>UniRef50_Q9H3Y6 Cluster: Tyrosine-protein kinase Srms; n=17;
Amniota|Rep: Tyrosine-protein kinase Srms - Homo sapiens
(Human)
Length = 488
Score = 109 bits (263), Expect = 5e-23
Identities = 77/229 (33%), Positives = 109/229 (47%), Gaps = 11/229 (4%)
Query: 38 EGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMAAC 97
EG FG +++G++ G + V +K + L+ GL H ++ A C
Sbjct: 238 EGYFGEVWEGLWL-GSL--PVAIKVIKSANMKLTDLAKEIQTLK--GLRHERLIRLHAVC 292
Query: 98 AEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQRFV 157
+ +P+ I NL+ FL + + A L+ QVA G+SYL QR V
Sbjct: 293 S--GGEPVYIVTELMRKGNLQAFLGT---PEGRALRLPPLLGFACQVAEGMSYLEEQRVV 347
Query: 158 HADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTA 217
H D+AARN +VD+ L KV D GLAR L DD + + PVKW APE +S
Sbjct: 348 HRDLAARNVLVDDGLACKVADFGLAR-LLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQK 406
Query: 218 SDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
SDVWS G+ L E+ T G P + + + GYR +P CP E+
Sbjct: 407 SDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEV 455
>UniRef50_UPI0000D577C3 Cluster: PREDICTED: similar to CG8874-PB,
isoform B; n=3; Endopterygota|Rep: PREDICTED: similar to
CG8874-PB, isoform B - Tribolium castaneum
Length = 801
Score = 109 bits (262), Expect = 7e-23
Identities = 67/231 (29%), Positives = 112/231 (48%), Gaps = 11/231 (4%)
Query: 36 IHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMA 95
I G FG +Y+ K + + V VKT EG L H N++ +
Sbjct: 545 IGRGNFGDVYRAQLKNSN--DVVAVKTCRVTLPEDHKKKFLQEGRILKQYDHPNIVKLIG 602
Query: 96 ACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQR 155
C + ++P++I +L FL +++A +L+ + A G+ YL +
Sbjct: 603 ICVQ--KQPIMIVMELVPGGSLLTFLR-----KKTALTDAQLMKMCLDAAAGMRYLESKN 655
Query: 156 FVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYS 215
+H D+AARNC+V +K++D G++R+ ++Y + P+KW APE L +Y+
Sbjct: 656 CIHRDLAARNCLVGYNNVVKISDFGMSRE--EEEYIVSDGMKQIPIKWTAPEALNFGKYT 713
Query: 216 TASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
+ DVWS GI WE+ + G +P + L + ++ GYR P N PDE+
Sbjct: 714 SLCDVWSYGILCWEIFSRGGTPYSGLSNSKAREKIDAGYRMPAPDNTPDEM 764
>UniRef50_Q9GRH2 Cluster: Tyrosine-protein kinase receptor; n=1;
Sycon raphanus|Rep: Tyrosine-protein kinase receptor -
Sycon raphanus
Length = 616
Score = 109 bits (262), Expect = 7e-23
Identities = 78/247 (31%), Positives = 113/247 (45%), Gaps = 27/247 (10%)
Query: 10 KDRVTDPAEQLRVLTTSRSNIRLEILIHEGTFGRIYKGVF---KKGDVYEEVMVKTXXXX 66
+D V DPA +L + S + IR + EG FG++Y+G+ + GD+ V +KT
Sbjct: 202 EDYVEDPAWEL--VPDSLTMIRE---VGEGAFGKVYEGLLATVEDGDM--TVAIKTLSVC 254
Query: 67 XXXXXXXXXXXEG-----------LRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSS 115
E +RL GLV P+ A L Y
Sbjct: 255 DTMGQRNAFLAEASIMKKFDSPYVMRLMGLVSTEN-KPLVVMEFMAEGDLRGYVRKCRPQ 313
Query: 116 NLKRFLSSCRLGQQSA-----PATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDE 170
N + ++S +A P + Q++ G++Y+H + FVH D+AARNC++
Sbjct: 314 NRQFSINSIETNGSAASVYGIPTAERFMLWALQLSKGMAYVHEKHFVHRDLAARNCMLSS 373
Query: 171 KLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWEL 230
L LK+ D G RD++ DY+ PV+WM PE L Y SDVWS G+ LWE+
Sbjct: 374 NLTLKIGDFGFTRDIYESDYYRKTGKGALPVRWMGPEALRDGMYIPESDVWSYGVVLWEM 433
Query: 231 ATLGSSP 237
ATLG P
Sbjct: 434 ATLGDQP 440
>UniRef50_Q9BKL8 Cluster: Tyrosine-protein kinase receptor; n=2;
Eumetazoa|Rep: Tyrosine-protein kinase receptor -
Aplysia californica (California sea hare)
Length = 1145
Score = 109 bits (262), Expect = 7e-23
Identities = 74/264 (28%), Positives = 118/264 (44%), Gaps = 16/264 (6%)
Query: 15 DPAEQLRVLTTSRSNIRLEILIHEGTFGRIYKG----VFKKGDVYEEVMVKTXXXXXXXX 70
+P R NIR + EG FG++YKG ++ + V V +KT
Sbjct: 556 NPKSASRAREFPMPNIRFLQELGEGAFGKVYKGELVGLYGESSV-TTVAIKTLKENALPK 614
Query: 71 XXXXXXXEGLRLYGLVHANVLTPMAACAEEARKPLLI-YCCP--------SHS--SNLKR 119
E + + H N++ + C ++ +L Y SHS S++
Sbjct: 615 VQNDFRREVDLMSDMRHPNIVCLLGVCMKQEPMCMLFEYMAQGDLHEYLLSHSPHSDVTA 674
Query: 120 FLSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDN 179
G E++ + QVA G+ YL FVH D+AARN +V + L +K++D
Sbjct: 675 AEDDSGTGGGHILEYSEMLHVSTQVAAGMEYLASHHFVHRDLAARNILVADGLTVKISDF 734
Query: 180 GLARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLA 239
GL+RD++ DY+ + PV+WM PE +L +++T SDVW+ G+ LWE+ + G P
Sbjct: 735 GLSRDVYSSDYYRVQSKSLLPVRWMPPEAILYGKFTTDSDVWAFGVVLWEVFSYGLQPYY 794
Query: 240 ELDAADVGAFLNGGYRPSQPHNCP 263
+V + P CP
Sbjct: 795 GFSNQEVIEMIRSRQILGCPEECP 818
>UniRef50_Q9BLY1 Cluster: Receptor tyrosine kinase; n=5;
Caenorhabditis|Rep: Receptor tyrosine kinase -
Caenorhabditis elegans
Length = 928
Score = 109 bits (261), Expect = 9e-23
Identities = 71/264 (26%), Positives = 117/264 (44%), Gaps = 8/264 (3%)
Query: 9 TKDRVTDPAEQLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVM---VKTXXX 65
+++ + D + ++ +T S+ ++R +I EG FG ++ G++ G E M VK
Sbjct: 571 SQEPIDDNSYKVFEITPSQLSVREKI--GEGQFGVVHSGIYTSGLFAPEPMAVAVKKCRH 628
Query: 66 XXXXXXXXXXXXEGLRLYGLVHANVLTPMAAC-AEEARKPLLIYCCPSHSSNLKRFLSSC 124
E + H NV+ + C + + + Y L +
Sbjct: 629 DATNAERAQLEQEIRAVATFDHPNVIKLIGVCYMDNSLLAVFEYMVHGDLHELLKVRVPP 688
Query: 125 RLGQQSA--PATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLA 182
A E + + Q+A G+ YL FVH D+A RNC+V + +K+ D GL
Sbjct: 689 ADHDMGGITEANAEFLYIATQIALGMEYLASMSFVHRDLATRNCLVGDTRTIKIADFGLM 748
Query: 183 RDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELD 242
R + DY+ + PV+WM+ E + Q ++S ASDVWS G+TLWE+ + G P
Sbjct: 749 RTSYGSDYYKMLHRSWMPVRWMSKEAIEQGRFSEASDVWSFGVTLWEIWSFGRQPYEGAS 808
Query: 243 AADVGAFLNGGYRPSQPHNCPDEL 266
V + + PHNCP +
Sbjct: 809 NQQVIELVANRHLLECPHNCPTNI 832
>UniRef50_Q7Z1D3 Cluster: Focal adhesion kinase; n=1; Lytechinus
variegatus|Rep: Focal adhesion kinase - Lytechinus
variegatus (Sea urchin)
Length = 1006
Score = 109 bits (261), Expect = 9e-23
Identities = 69/241 (28%), Positives = 112/241 (46%), Gaps = 8/241 (3%)
Query: 26 SRSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGL 85
SR + L I +G FG ++KG++ D EV VKT E +
Sbjct: 434 SRELVTLVETIGQGQFGDVHKGIYIDQDEKVEVAVKTCKVESTQALGERFLEEAYIMKQF 493
Query: 86 VHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVA 145
H +++ + C + P+ I + ++ FL + + L+ Q++
Sbjct: 494 DHPHIIKLIGVCTDP---PIWIVMELAPFGEMRMFLQT----HKEELTLASLILYAYQLS 546
Query: 146 CGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMA 205
LSYL ++FVH D+AARN +V K +K+ D GL+R L Y+ + P+KWMA
Sbjct: 547 MALSYLESKKFVHRDIAARNLLVVAKDNVKLGDFGLSRLLHDHSYYKASKGK-LPIKWMA 605
Query: 206 PETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDE 265
PE++ ++++ASDVW G+ +WE+ G P + +V + G R P CP
Sbjct: 606 PESINFRRFTSASDVWMFGVCMWEILMYGVKPFQGVKNNEVIGRIENGERLPMPAACPPT 665
Query: 266 L 266
L
Sbjct: 666 L 666
>UniRef50_Q24145 Cluster: Tyrosine-protein kinase shark; n=2;
Sophophora|Rep: Tyrosine-protein kinase shark -
Drosophila melanogaster (Fruit fly)
Length = 939
Score = 109 bits (261), Expect = 9e-23
Identities = 52/132 (39%), Positives = 77/132 (58%), Gaps = 1/132 (0%)
Query: 133 ATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHC 192
A EL +Q+ACG+ YL Q FVH D+AARN ++ + + K++D G++R L P
Sbjct: 762 ANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEY 821
Query: 193 LGDNENR-PVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLN 251
R P++W APE+ +S ASDVWS G+T+WE+ +LG+ P E+ D ++
Sbjct: 822 QFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVD 881
Query: 252 GGYRPSQPHNCP 263
G R QP+ CP
Sbjct: 882 SGERLPQPNLCP 893
>UniRef50_P09619 Cluster: Beta-type platelet-derived growth factor
receptor precursor; n=25; Amniota|Rep: Beta-type
platelet-derived growth factor receptor precursor - Homo
sapiens (Human)
Length = 1106
Score = 109 bits (261), Expect = 9e-23
Identities = 57/134 (42%), Positives = 80/134 (59%), Gaps = 5/134 (3%)
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGD 195
+LV QVA G+ +L + VH D+AARN ++ E +K+ D GLARD+ D +
Sbjct: 802 DLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKG 861
Query: 196 NENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNG--- 252
+ P+KWMAPE++ + Y+T SDVWS GI LWE+ TLG +P EL + F N
Sbjct: 862 STFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNE--QFYNAIKR 919
Query: 253 GYRPSQPHNCPDEL 266
GYR +QP + DE+
Sbjct: 920 GYRMAQPAHASDEI 933
>UniRef50_P53356 Cluster: Tyrosine-protein kinase HTK16; n=1; Hydra
vulgaris|Rep: Tyrosine-protein kinase HTK16 - Hydra
attenuata (Hydra) (Hydra vulgaris)
Length = 757
Score = 109 bits (261), Expect = 9e-23
Identities = 71/227 (31%), Positives = 110/227 (48%), Gaps = 9/227 (3%)
Query: 39 GTFGRIYKGVF-KKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMAAC 97
G FG + KG++ G V +KT E L + L H +++ + C
Sbjct: 493 GEFGSVIKGIWLSPGGKEINVAMKTLHKDKMVQGEKEFLREALVMSQLNHPCIVSLLGVC 552
Query: 98 AEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQRFV 157
P+++ L +L + Q +L +Q+A G+ YL ++RFV
Sbjct: 553 LGP---PMILVQELVEMGALLDYLMDYQPEIQEV----DLKLWASQIAFGMMYLELKRFV 605
Query: 158 HADVAARNCVVDEKLRLKVTDNGLARDLFP-DDYHCLGDNENRPVKWMAPETLLQNQYST 216
H D+AARN ++ K ++K++D GL+R + DY+ PV+W APE++ +ST
Sbjct: 606 HRDLAARNILLANKKQVKISDFGLSRAVGTGSDYYQAKQGGRWPVRWYAPESINYGTFST 665
Query: 217 ASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCP 263
SDVWS GITLWE+ T G P E+ +V +FL R +P CP
Sbjct: 666 KSDVWSYGITLWEMFTFGDLPYGEMTGNEVVSFLEHCGRLEKPDECP 712
>UniRef50_P18106 Cluster: Tyrosine-protein kinase Fps85D; n=12;
Eumetazoa|Rep: Tyrosine-protein kinase Fps85D -
Drosophila melanogaster (Fruit fly)
Length = 1325
Score = 109 bits (261), Expect = 9e-23
Identities = 68/241 (28%), Positives = 117/241 (48%), Gaps = 10/241 (4%)
Query: 26 SRSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGL 85
S ++ L I G FG +YK K + +V VKT EG L
Sbjct: 1059 SNDDVVLLERIGRGNFGDVYKAKLKSTKL--DVAVKTCRMTLPDEQKRKFLQEGRILKQY 1116
Query: 86 VHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVA 145
H N++ + C + ++P++I +L +L + TR+ + + A
Sbjct: 1117 DHPNIVKLIGICVQ--KQPIMIVMELVLGGSLLTYLRK----NSNGLTTRQQMGMCRDAA 1170
Query: 146 CGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMA 205
G+ YL + +H D+AARNC+VD + +K++D G++R+ ++Y + PVKW A
Sbjct: 1171 AGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTA 1228
Query: 206 PETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDE 265
PE L +Y++ DVWS GI +WE+ + G +P + + + ++ GYR P + P+E
Sbjct: 1229 PEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEE 1288
Query: 266 L 266
+
Sbjct: 1289 M 1289
>UniRef50_Q4H3M7 Cluster: Ephrin receptor; n=3; Ciona|Rep: Ephrin
receptor - Ciona intestinalis (Transparent sea squirt)
Length = 1006
Score = 108 bits (260), Expect = 1e-22
Identities = 72/238 (30%), Positives = 111/238 (46%), Gaps = 14/238 (5%)
Query: 30 IRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHAN 89
+ +E +I G FG + KG F + V +KT E + H N
Sbjct: 646 VNIEQVIGRGEFGEVCKGTFFN----KCVAIKTLKVGYNTQERSDFLGEASIMGQFDHPN 701
Query: 90 VLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGLS 149
V+ + +PL+I + +L FL + Q+ + +L ++ +A G+
Sbjct: 702 VIRLEGVVTKS--RPLMIITEFMENGSLDAFLRN----QEGKIPSAQLTEMLLSIAQGME 755
Query: 150 YLHVQRFVHADVAARNCVVDEKLRLKVTDNGLAR---DLFPDDYHCLGDNENR-PVKWMA 205
YL +VH D+AARN +V+ L KV+D GL+R L DD P++W +
Sbjct: 756 YLSNMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEQLEEDDVAMYTTRGGMIPIRWTS 815
Query: 206 PETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCP 263
PE + +ST+SDVWS GI +WE+ + G P E+ DV F++ GYR P CP
Sbjct: 816 PEAITMRTFSTSSDVWSFGIVMWEVMSFGERPYWEMSNQDVVQFVDSGYRLPPPCYCP 873
>UniRef50_Q179Z3 Cluster: Tyrosine-protein kinase; n=1; Aedes
aegypti|Rep: Tyrosine-protein kinase - Aedes aegypti
(Yellowfever mosquito)
Length = 343
Score = 108 bits (260), Expect = 1e-22
Identities = 51/132 (38%), Positives = 79/132 (59%), Gaps = 4/132 (3%)
Query: 135 RELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLG 194
+EL D Q+ACG+ +L + H D+AARN ++DEK LK++D GL+R +
Sbjct: 157 KELHDFARQIACGMKHLEEKNITHRDLAARNILIDEKKTLKISDFGLSRT----GIYVNT 212
Query: 195 DNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGY 254
N+ P++W++ E + + YS+ SDVW+ GI LWE+ TLG P + ++ +FL+ G
Sbjct: 213 RNKKVPLRWLSIEAMRDHLYSSKSDVWAFGIVLWEIGTLGGYPYPTVSNHELLSFLHNGN 272
Query: 255 RPSQPHNCPDEL 266
R +P NC EL
Sbjct: 273 RLDRPENCSAEL 284
>UniRef50_A7SE14 Cluster: Predicted protein; n=4; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 311
Score = 108 bits (260), Expect = 1e-22
Identities = 78/252 (30%), Positives = 117/252 (46%), Gaps = 17/252 (6%)
Query: 24 TTSRSNIRLEILIHEGTFGRIYKG----VFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEG 79
T R I + +I G FG+++KG + + V +K+ E
Sbjct: 6 TVPRERIHIMKVIGNGAFGQVHKGRVHGLGTNSPGWTLVAIKSPYADASDAETRDLMKEF 65
Query: 80 LRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQS-------AP 132
L L + + C E+ +PL+I H +L +L R + S P
Sbjct: 66 ELLKRLKSHPHVIKLLGCGEDDGRPLVIIEYVPHG-DLLGYLRKSRGEEDSYYPDPEIKP 124
Query: 133 AT----RELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPD 188
T ++LV QVA G+ YL Q+ +H D+AARN +V E KVTD G+A+D+ +
Sbjct: 125 KTSLSSQQLVRFAWQVADGMQYLSSQKIIHRDLAARNILVGEGEVCKVTDFGMAKDVQNE 184
Query: 189 DYHCLGDNENRPVKWMAPETLL-QNQYSTASDVWSLGITLWELATLGSSPLAELDAADVG 247
D + PVKW A E L+ +Y+T SDVWS G+ L+E+ T+G P + D+
Sbjct: 185 DIYIRTTEGRLPVKWTAIEALIGGGEYTTQSDVWSFGVVLYEICTIGGEPYPGIAGKDIP 244
Query: 248 AFLNGGYRPSQP 259
+L GYR S P
Sbjct: 245 EYLEAGYRMSCP 256
>UniRef50_Q96Q04 Cluster: Serine/threonine-protein kinase LMTK3
precursor; n=13; Eutheria|Rep: Serine/threonine-protein
kinase LMTK3 precursor - Homo sapiens (Human)
Length = 1460
Score = 108 bits (260), Expect = 1e-22
Identities = 72/240 (30%), Positives = 112/240 (46%), Gaps = 14/240 (5%)
Query: 23 LTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRL 82
L SR ++ I G FG++ G +V+VK E
Sbjct: 126 LGLSRQHLSYLQEIGSGWFGKVILGEIFSDYTPAQVVVKELRASAGPLEQRKFISEAQPY 185
Query: 83 YGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPAT-----REL 137
L H NVL + C E L++ C +LKR+L + R + +P R L
Sbjct: 186 RSLQHPNVLQCLGLCVETLPFLLIMEFC--QLGDLKRYLRAQRPPEGLSPELPPRDLRTL 243
Query: 138 VDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNE 197
+G ++A GL++LH +VH+D+A RNC++ L +++ D GLA + +DY+ +
Sbjct: 244 QRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERL 303
Query: 198 NRPVKWMAPE-------TLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFL 250
P++W APE T + S S++WSLG+TLWEL G+ P L +V AF+
Sbjct: 304 WIPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFV 363
>UniRef50_P04626 Cluster: Receptor tyrosine-protein kinase erbB-2
precursor; n=36; Euteleostomi|Rep: Receptor
tyrosine-protein kinase erbB-2 precursor - Homo sapiens
(Human)
Length = 1255
Score = 108 bits (260), Expect = 1e-22
Identities = 79/249 (31%), Positives = 118/249 (47%), Gaps = 17/249 (6%)
Query: 19 QLRVLTTSRSNIRLEILIHEGTFGRIYKGVF-KKGD-VYEEVMVKTXXXXXXXXXXXXXX 76
Q+R+L + +R ++ G FG +YKG++ G+ V V +K
Sbjct: 711 QMRIL--KETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEIL 768
Query: 77 XEGLRLYGLVHANVLTPMAACAEEARK---PLLIYCCPSHSSNLKRFLSSCRLGQQSAPA 133
E + G+ V + C + L+ Y C R RLG Q
Sbjct: 769 DEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRG----RLGSQ---- 820
Query: 134 TRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCL 193
+L++ Q+A G+SYL R VH D+AARN +V +K+TD GLAR L D+
Sbjct: 821 --DLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYH 878
Query: 194 GDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGG 253
D P+KWMA E++L+ +++ SDVWS G+T+WEL T G+ P + A ++ L G
Sbjct: 879 ADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKG 938
Query: 254 YRPSQPHNC 262
R QP C
Sbjct: 939 ERLPQPPIC 947
>UniRef50_Q4SWL0 Cluster: Ephrin receptor; n=3; Tetraodontidae|Rep:
Ephrin receptor - Tetraodon nigroviridis (Green puffer)
Length = 1072
Score = 108 bits (259), Expect = 2e-22
Identities = 77/255 (30%), Positives = 120/255 (47%), Gaps = 14/255 (5%)
Query: 15 DPAEQLRVLTTS--RSNIRLEILIHEGTFGRIYKGVFK---KGDVYEEVMVKTXXXXXXX 69
DP + +R SNIR+E +I G FG + G + K ++Y V +K+
Sbjct: 706 DPNQAIRDFAKEIDASNIRIERVIGAGEFGEVCSGRLRVQGKREIY--VAIKSLKAGYSD 763
Query: 70 XXXXXXXXEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQ 129
E + H N++ KP++I + +L FL GQ
Sbjct: 764 KQRRDFLSEASIMGQFDHPNIIRLEGVVTR--CKPVMIITEFMENGSLDTFLKK-HDGQF 820
Query: 130 SAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDD 189
+ +LV + +A G+ YL +VH D+AARN +V+ L KV+D GL+R L D
Sbjct: 821 TVI---QLVGMLRGIASGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDP 877
Query: 190 YHCLGDNENR-PVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGA 248
+ P++W APE + ++++ASDVWS GI +WE+ + G P E+ DV
Sbjct: 878 EAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVISYGERPYWEMSNQDVIK 937
Query: 249 FLNGGYRPSQPHNCP 263
++ GYR P +CP
Sbjct: 938 AIDEGYRLPAPMDCP 952
>UniRef50_Q1HTP1 Cluster: Tyrosine-protein kinase receptor; n=1;
Astatotilapia burtoni|Rep: Tyrosine-protein kinase
receptor - Haplochromis burtoni (Burton's mouthbrooder)
Length = 998
Score = 108 bits (259), Expect = 2e-22
Identities = 64/178 (35%), Positives = 92/178 (51%), Gaps = 7/178 (3%)
Query: 94 MAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQ---QSAPATRELVDLGAQVACGLSY 150
MAA R I CC S ++ LS + Q + +L+ QV+ GL +
Sbjct: 735 MAAQHARLRSDSGISCC-SEYQEMQPILSPGQTHQGVQTDGLSVSDLISFSYQVSQGLDF 793
Query: 151 LHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPETLL 210
L + +H DVAARN ++ ++ K+ D GLARD+ DD + + N PVKWMAPE++
Sbjct: 794 LSTRNCIHRDVAARNVLLTDRRVAKICDFGLARDIRNDDSYIVQGNARLPVKWMAPESIF 853
Query: 211 QNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAF--LNGGYRPSQPHNCPDEL 266
Q Y+ SDVWS G+ LWE+ +LG SP + A D + + G QP P E+
Sbjct: 854 QCVYTVQSDVWSYGVLLWEIFSLGKSPYPNI-AVDTNFYKMIKDGGHMEQPDFAPAEM 910
>UniRef50_Q9TX48 Cluster: 220 kDa ABL-related protein tyrosine
kinase; n=3; Strongylocentrotus purpuratus|Rep: 220 kDa
ABL-related protein tyrosine kinase - Strongylocentrotus
purpuratus (Purple sea urchin)
Length = 200
Score = 108 bits (259), Expect = 2e-22
Identities = 57/132 (43%), Positives = 77/132 (58%), Gaps = 2/132 (1%)
Query: 128 QQSAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFP 187
+ S PA L+ + QVA G+SYL F+H D+AARNC++ E LKV D GLAR +
Sbjct: 17 ETSLPAVT-LLYMATQVAFGMSYLEKNSFIHRDLAARNCLLGEHHLLKVADFGLAR-MVQ 74
Query: 188 DDYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVG 247
+ + P+KW APE+L ++S+ SDVW+ GI LWE+AT G SP +D V
Sbjct: 75 GEIYTAQAGAKFPIKWTAPESLAYVKFSSKSDVWAFGILLWEIATYGCSPYPGVDLQHVY 134
Query: 248 AFLNGGYRPSQP 259
L GYR +P
Sbjct: 135 GKLEQGYRMERP 146
>UniRef50_P00528 Cluster: Tyrosine-protein kinase Src64B; n=6;
Endopterygota|Rep: Tyrosine-protein kinase Src64B -
Drosophila melanogaster (Fruit fly)
Length = 552
Score = 108 bits (259), Expect = 2e-22
Identities = 74/242 (30%), Positives = 115/242 (47%), Gaps = 13/242 (5%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLV 86
RS I+L + G FG ++ G ++ +V VKT ++ +
Sbjct: 281 RSEIQLLRKLGRGNFGEVFYGKWRNSI---DVAVKTLREGTMSTAAFLQEAAIMKKFR-- 335
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVAC 146
H ++ A C++E +P+ I +L FL R G +L+ + QVA
Sbjct: 336 HNRLVALYAVCSQE--EPIYIVQEYMSKGSLLDFL---REGDGRYLHFEDLIYIATQVAS 390
Query: 147 GLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAP 206
G+ YL ++ +H D+AARN ++ E K+ D GLAR + DD +C PVKW AP
Sbjct: 391 GMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLAR-VIADDEYCPKQGSRFPVKWTAP 449
Query: 207 ETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQP--HNCPD 264
E ++ ++S SDVWS GI L EL T G P + + +V + G+R +P H PD
Sbjct: 450 EAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPD 509
Query: 265 EL 266
+
Sbjct: 510 NI 511
>UniRef50_Q5TRF2 Cluster: ENSANGP00000025511; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000025511 - Anopheles gambiae
str. PEST
Length = 693
Score = 107 bits (258), Expect = 2e-22
Identities = 48/135 (35%), Positives = 81/135 (60%)
Query: 132 PATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYH 191
P + +L++ Q+A G+ +L + VH D+AARN +V + +K+ D GL+RD++ ++ +
Sbjct: 559 PNSGQLLEFSRQIALGMEFLARNKVVHRDLAARNVLVCDSNTVKIADFGLSRDIYQENLY 618
Query: 192 CLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLN 251
N P+KW+A E++ Y++ SDVWS GI L+E+ TLG SP + + +L
Sbjct: 619 RKTSNGKLPIKWLALESMTHQVYTSQSDVWSYGILLYEICTLGGSPYPAISTNRLLRYLE 678
Query: 252 GGYRPSQPHNCPDEL 266
GYR +P +C + L
Sbjct: 679 SGYRMERPKSCSELL 693
>UniRef50_P79749 Cluster: Beta-type platelet-derived growth factor
receptor precursor; n=9; Clupeocephala|Rep: Beta-type
platelet-derived growth factor receptor precursor - Fugu
rubripes (Japanese pufferfish) (Takifugu rubripes)
Length = 1048
Score = 107 bits (258), Expect = 2e-22
Identities = 54/132 (40%), Positives = 81/132 (61%), Gaps = 1/132 (0%)
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGD 195
+L+ QVA G+ +L + VH D+AARN ++ E +K+ D GLARD+ D +
Sbjct: 797 DLLGFSYQVAKGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMHDSNYISKG 856
Query: 196 NENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADV-GAFLNGGY 254
+ P+KWMAPE++ N Y+T SDVWS GI LWE+ TLG +P +L ++ + L GY
Sbjct: 857 STFLPLKWMAPESIFHNLYTTLSDVWSYGILLWEIFTLGGTPYPDLPMNELFYSPLKRGY 916
Query: 255 RPSQPHNCPDEL 266
R ++P + DE+
Sbjct: 917 RMAKPAHASDEV 928
>UniRef50_Q66I04 Cluster: Zgc:92124; n=1; Danio rerio|Rep: Zgc:92124
- Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 510
Score = 107 bits (257), Expect = 3e-22
Identities = 48/131 (36%), Positives = 77/131 (58%), Gaps = 1/131 (0%)
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGD 195
+L+D AQ+A G++Y+ + ++H D+ A N +V E L K+ D GLAR + DD + +
Sbjct: 341 KLIDFSAQIAEGMAYIEKKNYIHRDLRAANVLVSEMLLCKIADFGLAR-VIEDDQYTARE 399
Query: 196 NENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYR 255
P+KW APE + ++ SD+WS G+ L+E+ T G P + ++V + + GYR
Sbjct: 400 GAKFPIKWTAPEAINYGSFTIKSDMWSFGVLLYEIITYGKIPYPGMSNSEVMSSVQRGYR 459
Query: 256 PSQPHNCPDEL 266
+P NCP EL
Sbjct: 460 MPRPENCPVEL 470
>UniRef50_P18475 Cluster: Tyrosine-protein kinase receptor torso
precursor; n=2; Sophophora|Rep: Tyrosine-protein kinase
receptor torso precursor - Drosophila melanogaster
(Fruit fly)
Length = 923
Score = 107 bits (257), Expect = 3e-22
Identities = 48/132 (36%), Positives = 79/132 (59%), Gaps = 1/132 (0%)
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDD-YHCLG 194
+L+D+ QVA G+ +L + VH D+AARN ++ +K+ D GL+RD++ ++ Y G
Sbjct: 717 DLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVYHENVYRKSG 776
Query: 195 DNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGY 254
+ P+KW+A E+L Y++ SDVWS G+ L+E+ TLG P + +D+ L G+
Sbjct: 777 GSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVSPSDLLQLLRQGH 836
Query: 255 RPSQPHNCPDEL 266
R +P C E+
Sbjct: 837 RMKRPEGCTQEM 848
>UniRef50_Q9Y1Y3 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 893
Score = 107 bits (256), Expect = 4e-22
Identities = 70/234 (29%), Positives = 109/234 (46%), Gaps = 7/234 (2%)
Query: 30 IRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHAN 89
I+L I G FG +YKG++ + + VKT E + H N
Sbjct: 535 IKLVEEIGGGEFGTVYKGMWNERKPPVPIAVKTLKPGSSDKMRDDFLTEASIMGQFHHPN 594
Query: 90 VLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGLS 149
V+ + +P +I + +L +L + ++L+ + VA G+
Sbjct: 595 VIKLYGVITKV--EPAMIIMEFMDNGSLYYYLRH----NDEKLSLQQLLKMACGVAAGMQ 648
Query: 150 YLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPETL 209
YL +VH D+AARN +V + KV D GL+R+ D+Y + PV+W APE +
Sbjct: 649 YLSEVGYVHRDLAARNILVSKDEVCKVADFGLSRETTNDEYD-VKKGGKIPVRWTAPEAI 707
Query: 210 LQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCP 263
+++TASDVWS G+ LWE+ + G P + D V L GYR +P +CP
Sbjct: 708 SYRKFTTASDVWSYGVLLWEVMSYGQQPYEDWDNQMVLDKLESGYRLQKPKDCP 761
>UniRef50_Q7QAK4 Cluster: ENSANGP00000020257; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000020257 - Anopheles gambiae
str. PEST
Length = 1192
Score = 107 bits (256), Expect = 4e-22
Identities = 67/241 (27%), Positives = 113/241 (46%), Gaps = 9/241 (3%)
Query: 26 SRSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGL 85
S ++ L I G FG +YK K V VKT EG L
Sbjct: 927 SNDDVILLDKIGRGNFGDVYKAKLKSSK-NTLVAVKTCRMTLPEEQKRKFLQEGRILKQY 985
Query: 86 VHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVA 145
H N++ + C + ++P++I +L FL S R+++ + A
Sbjct: 986 DHPNIVKLIGICVQ--KQPIMIVMELVAGGSLLMFLRK----NASTLGQRQMMGMCRDAA 1039
Query: 146 CGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMA 205
G+ YL + +H D+AARNC++ + +K++D G++R+ ++Y G + P+KW A
Sbjct: 1040 AGMRYLESKNCIHRDLAARNCLIGSENIVKISDFGMSRE--EEEYIVSGGMKQIPIKWTA 1097
Query: 206 PETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDE 265
PE L +Y++ DVWS GI +WE+ + G +P + + + ++ GYR P P E
Sbjct: 1098 PEALNFGKYTSLCDVWSYGILVWEIFSRGDTPYSGMSNSMARERIDEGYRMPAPEGAPPE 1157
Query: 266 L 266
+
Sbjct: 1158 M 1158
>UniRef50_Q17JW1 Cluster: Tyrosine protein kinase; n=2;
Culicidae|Rep: Tyrosine protein kinase - Aedes aegypti
(Yellowfever mosquito)
Length = 722
Score = 107 bits (256), Expect = 4e-22
Identities = 65/227 (28%), Positives = 106/227 (46%), Gaps = 5/227 (2%)
Query: 16 PAEQLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKKGDV-YEEVMVKTXXXXXXXXXXXX 74
P L + + + + EG FG +Y G + GD + V VKT
Sbjct: 279 PVNTLDKWEVPKDRVVINRRLGEGAFGTVYGGEAQIGDEGWTAVAVKTLKIGSTTEDKVD 338
Query: 75 XXXEGLRLYGLVHANVLTPMAACAEEAR----KPLLIYCCPSHSSNLKRFLSSCRLGQQS 130
E + H N++ + C + ++Y +R L + + + S
Sbjct: 339 FLSEAEAMKRFDHNNIVKLLGVCLQTEPVYTIMEFMLYGDLKTYLLARRHLVNSKQSEDS 398
Query: 131 APATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDY 190
+ + L + V+ LSYL Q++VH D+A RNC+V+ + +K+ D G+AR F +DY
Sbjct: 399 DISPKRLTMMALDVSRALSYLAEQKYVHRDLACRNCMVNAQRVVKLGDFGMARPTFENDY 458
Query: 191 HCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSP 237
+ PV+WMAPE+L ++ ASDVWS G+ L+E+ + GS P
Sbjct: 459 YRFNRKGMLPVRWMAPESLALGIFTPASDVWSYGVLLYEIISFGSFP 505
>UniRef50_P00534 Cluster: Tyrosine-protein kinase transforming
protein erbB; n=8; root|Rep: Tyrosine-protein kinase
transforming protein erbB - Avian leukosis virus (ALV)
Length = 634
Score = 107 bits (256), Expect = 4e-22
Identities = 52/126 (41%), Positives = 76/126 (60%)
Query: 137 LVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDN 196
L++ Q+A G++YL +R VH D+AARN +V +K+TD GLA+ L D+ +
Sbjct: 234 LLNWCVQIAKGMNYLEERRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGADEKEYHAEG 293
Query: 197 ENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRP 256
P+KWMA E++L Y+ SDVWS G+T+WEL T GS P + A+++ + L G R
Sbjct: 294 GKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSVLEKGERL 353
Query: 257 SQPHNC 262
QP C
Sbjct: 354 PQPPIC 359
>UniRef50_Q6SAW1 Cluster: Epidermal growth factor receptor; n=70;
Drosophila melanogaster|Rep: Epidermal growth factor
receptor - Drosophila melanogaster (Fruit fly)
Length = 1325
Score = 106 bits (255), Expect = 5e-22
Identities = 66/210 (31%), Positives = 102/210 (48%), Gaps = 9/210 (4%)
Query: 39 GTFGRIYKGVF-KKGD-VYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMAA 96
G FGR+YKGV+ +G+ V V +K E + + H N+L +A
Sbjct: 846 GAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAV 905
Query: 97 CAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQRF 156
C ++ L+ P L L R + ++ L++ Q+A G+SYL +R
Sbjct: 906 CMS-SQMMLITQLMP-----LGCLLDYVRNNRDKI-GSKALLNWSTQIAKGMSYLEEKRL 958
Query: 157 VHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYST 216
VH D+AARN +V +K+TD GLA+ L D P+KW+A E + +++
Sbjct: 959 VHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTS 1018
Query: 217 ASDVWSLGITLWELATLGSSPLAELDAADV 246
SDVW+ G+T+WEL T G P + A D+
Sbjct: 1019 KSDVWAFGVTIWELLTFGQRPHENIPAKDI 1048
>UniRef50_UPI00015A7C25 Cluster: UPI00015A7C25 related cluster; n=3;
Danio rerio|Rep: UPI00015A7C25 UniRef100 entry - Danio
rerio
Length = 759
Score = 106 bits (254), Expect = 7e-22
Identities = 71/238 (29%), Positives = 111/238 (46%), Gaps = 15/238 (6%)
Query: 36 IHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLV-HANVLTPM 94
I G FG ++ G + + V VK E R+ H N++ +
Sbjct: 497 IGRGNFGEVFSGRLRSDNT--PVAVKACRENLPAEHKNKFLMEAARILKQYDHPNIVKLI 554
Query: 95 AACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQ 154
C + ++P+ I + FL + +S+ L+ + VA GL+YL +
Sbjct: 555 GVCTQ--KQPIYIIMELVQGGDFLTFLRTEGHNLKSSM----LIRMAENVASGLAYLESK 608
Query: 155 RFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPETL---LQ 211
+ +H DVAARNC+V E+ +K++D G++R+ Y G + PVKW APE L
Sbjct: 609 KCIHRDVAARNCLVGEESVVKISDFGMSREEQDGVYSATGGMKQIPVKWTAPEALNYGSP 668
Query: 212 NQYSTASDVWSLGITLWELATLGSSPL---AELDAADVGAFLNGGYRPSQPHNCPDEL 266
+Y+T SDVWS G+ LWE + G +P + + GYR P+NCPDE+
Sbjct: 669 GRYTTESDVWSFGVLLWETFSRGVTPYTIPTVMSNQQTRDEVERGYRMPAPNNCPDEI 726
>UniRef50_Q17IF1 Cluster: Receptor protein tyrosine kinase; n=1;
Aedes aegypti|Rep: Receptor protein tyrosine kinase -
Aedes aegypti (Yellowfever mosquito)
Length = 636
Score = 106 bits (254), Expect = 7e-22
Identities = 50/133 (37%), Positives = 79/133 (59%)
Query: 134 TRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCL 193
+R+L++ Q+A G+ +L + VH D+AARN +V +K++D GL+RD++ + +
Sbjct: 440 SRQLLEFAKQIAIGMEFLARNKVVHRDLAARNVLVCYDKAVKISDFGLSRDIYQQNLYRK 499
Query: 194 GDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGG 253
P+KW+A E+L Y++ SDVWS GI L+E+ TLG +P L D+ L G
Sbjct: 500 TGTGKLPIKWLALESLTHQVYTSQSDVWSYGILLYEICTLGGNPYPLLSTCDLIMELKRG 559
Query: 254 YRPSQPHNCPDEL 266
YR +P +C EL
Sbjct: 560 YRMEKPDSCSKEL 572
>UniRef50_P07947 Cluster: Proto-oncogene tyrosine-protein kinase
Yes; n=422; root|Rep: Proto-oncogene tyrosine-protein
kinase Yes - Homo sapiens (Human)
Length = 543
Score = 106 bits (254), Expect = 7e-22
Identities = 74/240 (30%), Positives = 113/240 (47%), Gaps = 12/240 (5%)
Query: 27 RSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLV 86
R ++RLE+ + +G FG ++ G + G +V +KT + ++ L
Sbjct: 274 RESLRLEVKLGQGCFGEVWMGTWN-GTT--KVAIKTLKPGTMMPEAFLQEAQIMKK--LR 328
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVAC 146
H + L P+ A E +P+ I +L FL G +LVD+ AQ+A
Sbjct: 329 H-DKLVPLYAVVSE--EPIYIVTEFMSKGSLLDFLKE---GDGKYLKLPQLVDMAAQIAD 382
Query: 147 GLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAP 206
G++Y+ ++H D+ A N +V E L K+ D GLAR L D+ + P+KW AP
Sbjct: 383 GMAYIERMNYIHRDLRAANILVGENLVCKIADFGLAR-LIEDNEYTARQGAKFPIKWTAP 441
Query: 207 ETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
E L +++ SDVWS GI EL T G P + +V + GYR P CP+ L
Sbjct: 442 EAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESL 501
>UniRef50_Q15303 Cluster: Receptor tyrosine-protein kinase erbB-4
precursor; n=58; Euteleostomi|Rep: Receptor
tyrosine-protein kinase erbB-4 precursor - Homo sapiens
(Human)
Length = 1308
Score = 106 bits (254), Expect = 7e-22
Identities = 73/246 (29%), Positives = 117/246 (47%), Gaps = 11/246 (4%)
Query: 19 QLRVLTTSRSNIRLEILIHEGTFGRIYKGVF-KKGDVYE-EVMVKTXXXXXXXXXXXXXX 76
QLR+L + R+++L G FG +YKG++ +G+ + V +K
Sbjct: 709 QLRILKETELK-RVKVL-GSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFM 766
Query: 77 XEGLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRE 136
E L + + H +++ + C + L+ P H L+ + ++
Sbjct: 767 DEALIMASMDHPHLVRLLGVCLSPTIQ-LVTQLMP-HGCLLEYVHE-----HKDNIGSQL 819
Query: 137 LVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDN 196
L++ Q+A G+ YL +R VH D+AARN +V +K+TD GLAR L D+ D
Sbjct: 820 LLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADG 879
Query: 197 ENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRP 256
P+KWMA E + +++ SDVWS G+T+WEL T G P + ++ L G R
Sbjct: 880 GKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERL 939
Query: 257 SQPHNC 262
QP C
Sbjct: 940 PQPPIC 945
>UniRef50_Q4SP88 Cluster: Ephrin receptor; n=2; Tetraodon
nigroviridis|Rep: Ephrin receptor - Tetraodon
nigroviridis (Green puffer)
Length = 950
Score = 105 bits (252), Expect = 1e-21
Identities = 74/240 (30%), Positives = 110/240 (45%), Gaps = 10/240 (4%)
Query: 28 SNIRLEILIHEGTFGRIYKGVFKKGDVYEEVM-VKTXXXXXXXXXXXXXXXEGLRLYGLV 86
S +++E +I G FG + +G K+ E V+ +KT E +
Sbjct: 634 SCVKIEEVIGAGEFGEVCRGRLKQAGRREMVVAIKTLKAGYTERQRRDFLAEASIMGQFD 693
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVAC 146
H NV+ P+LI + L FL RL T +LV + VA
Sbjct: 694 HPNVIRLEGVLTRSC--PVLIITEFMENGALDSFL---RLNDGRFTMT-QLVGMLRGVAA 747
Query: 147 GLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLAR---DLFPDDYHCLGDNENRPVKW 203
G+ YL +VH D+AARN +V+ L KV+D GL+R D D + P++W
Sbjct: 748 GMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLDDTSADPTYTSSLGGKIPIRW 807
Query: 204 MAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCP 263
APE + +++TASDVWS GI +WE+ + G P ++ DV + YR P +CP
Sbjct: 808 TAPEAIAFRKFTTASDVWSYGIVMWEVVSYGERPYWDMSNQDVMTAVEQDYRLPPPMDCP 867
>UniRef50_Q8WSM2 Cluster: Receptor tyrosine kinase; n=1; Schistosoma
mansoni|Rep: Receptor tyrosine kinase - Schistosoma
mansoni (Blood fluke)
Length = 1559
Score = 105 bits (252), Expect = 1e-21
Identities = 66/236 (27%), Positives = 107/236 (45%), Gaps = 8/236 (3%)
Query: 19 QLRVLTTSRSNIRLEILIHEGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXE 78
+L+ + ++I L + +G FG +Y G K+ +E V VK E
Sbjct: 985 ELKDIDIPPADIVLNRRVGQGAFGMVYGGEAKRNGRWEAVAVKVIGNKSTYEGKTDFLSE 1044
Query: 79 GLRLYGLVHANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAP-----A 133
+ L H NV+ + C L + + +LK +L S R+ Q P
Sbjct: 1045 AKLMRSLDHRNVVRLVGICLYPKENHLYLIMEFMLNGDLKTYLLSRRVLAQQVPDHDGVC 1104
Query: 134 TRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDD---Y 190
L + +A GL+YLH + +H D+A RNC+V +K+ D GL R++ + Y
Sbjct: 1105 PATLTGMAIDIAEGLAYLHRKNLIHRDIACRNCLVGSDGIVKIGDFGLTREMNSSENEGY 1164
Query: 191 HCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADV 246
+ N P++WM+PE + +S SD+WS GI L+E+ T G P L ++
Sbjct: 1165 YRFTRNCELPIRWMSPEAVQFGIFSVHSDIWSYGIVLYEIITFGVFPYDGLSDVEI 1220
>UniRef50_Q86LZ8 Cluster: Insulin receptor protein kinase; n=2;
Schistosoma|Rep: Insulin receptor protein kinase -
Schistosoma mansoni (Blood fluke)
Length = 1499
Score = 105 bits (252), Expect = 1e-21
Identities = 54/138 (39%), Positives = 79/138 (57%), Gaps = 1/138 (0%)
Query: 129 QSAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPD 188
Q + T+ ++ Q+A G++YL +H D+AARNC+V+ L +K+ D GLAR +
Sbjct: 1324 QGSIDTQLAINWAIQLATGMNYLAELHIIHRDLAARNCLVNSMLTVKIADFGLARLVNNQ 1383
Query: 189 DYHCLGDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGA 248
+Y+ PV+WMAPETL ++T SDVWS G+ LWE+AT S P L +V
Sbjct: 1384 EYYRKIGQARLPVRWMAPETLSSAYFTTKSDVWSYGVVLWEIATFASLPYPGLSHEEVMK 1443
Query: 249 FLNGGYRPSQPHNCPDEL 266
F+ G + P CP +L
Sbjct: 1444 FVCDGGHLNLP-ECPTKL 1460
>UniRef50_Q6TYB9 Cluster: Dauer abnormal formation-2 precursor; n=2;
Caenorhabditis briggsae|Rep: Dauer abnormal formation-2
precursor - Caenorhabditis briggsae
Length = 1807
Score = 105 bits (252), Expect = 1e-21
Identities = 47/130 (36%), Positives = 78/130 (60%)
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGD 195
++ + AQ+ G++YL +F H D+AARNC++D+ +K+ D G+ARDLF DY+
Sbjct: 1322 KICEWAAQICDGMAYLESLKFCHRDLAARNCMIDKTELVKIGDFGMARDLFYHDYYKPSG 1381
Query: 196 NENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYR 255
PV+WM+PE+L ++ + SD+WS G+ L+EL TLG+ P L +V ++ +
Sbjct: 1382 KRMMPVRWMSPESLKDGKFDSKSDIWSFGVVLYELITLGAQPYIGLSNDEVLNYIGMARK 1441
Query: 256 PSQPHNCPDE 265
+ +C E
Sbjct: 1442 VIKKPDCCSE 1451
>UniRef50_Q6SAJ2 Cluster: Epidermal growth factor receptor; n=11;
Diptera|Rep: Epidermal growth factor receptor -
Drosophila melanogaster (Fruit fly)
Length = 1325
Score = 105 bits (252), Expect = 1e-21
Identities = 68/226 (30%), Positives = 104/226 (46%), Gaps = 9/226 (3%)
Query: 39 GTFGRIYKGVF-KKGD-VYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMAA 96
G FGR+YKGV+ +G+ V V +K E + L +A
Sbjct: 846 GAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMAXXXXXXXLKLLAV 905
Query: 97 CAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQRF 156
C ++ L+ P L L R + ++ L++ Q+A G+SYL +R
Sbjct: 906 CMS-SQMMLITQLMP-----LGCLLDYVRNNRDKI-GSKALLNWSTQIAKGMSYLEEKRL 958
Query: 157 VHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYST 216
VH D+AARN +V +K+TD GLA+ L D P+KW+A E + +++
Sbjct: 959 VHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTS 1018
Query: 217 ASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNC 262
SDVW+ G+T+WEL T G P + A D+ + G + QP C
Sbjct: 1019 KSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEIC 1064
>UniRef50_Q4H2M8 Cluster: Tyrosine-protein kinase receptor; n=1;
Ciona intestinalis|Rep: Tyrosine-protein kinase receptor
- Ciona intestinalis (Transparent sea squirt)
Length = 817
Score = 105 bits (252), Expect = 1e-21
Identities = 53/133 (39%), Positives = 77/133 (57%), Gaps = 2/133 (1%)
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPD-DYHCLG 194
+L+ QVA G+ +L ++ +H D+AARN ++ + +K+ D GLARD++ D DY G
Sbjct: 522 DLLSYSLQVARGMEFLASKKCIHRDLAARNVLLSDYQVVKICDFGLARDIYKDPDYVRSG 581
Query: 195 DNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDA-ADVGAFLNGG 253
+ P+KWMAPE++ YS SDVWS G+ LWE+ TLG SP L D L G
Sbjct: 582 GDARLPIKWMAPESIFDKVYSNKSDVWSFGVLLWEIFTLGGSPYPGLQMDEDFCNKLRRG 641
Query: 254 YRPSQPHNCPDEL 266
R +P + D +
Sbjct: 642 VRMGKPEHATDSV 654
>UniRef50_O76809 Cluster: Receptor tyrosine kinase HTK30; n=1; Hydra
vulgaris|Rep: Receptor tyrosine kinase HTK30 - Hydra
attenuata (Hydra) (Hydra vulgaris)
Length = 1081
Score = 105 bits (252), Expect = 1e-21
Identities = 52/151 (34%), Positives = 86/151 (56%), Gaps = 3/151 (1%)
Query: 117 LKRFLSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKV 176
+++ + L + + +L+ QVA G+ YL +FVH D+AARN +V +K+
Sbjct: 912 IRKTSNEVSLMEMGSLTPNDLLCFAWQVASGMEYLACMKFVHRDLAARNILVGANKNIKI 971
Query: 177 TDNGLARDLFPDDYHCLGDNENR-PVKWMAPETLLQNQYSTASDVWSLGITLWELATLGS 235
+D GL R + D Y +G R PVKWM+ E + ++++SDVWS G+ L+E+ TLG
Sbjct: 972 SDFGLTRKVDLDVY--MGAKSRRLPVKWMSIEAIFDRTFTSSSDVWSFGVVLFEIITLGG 1029
Query: 236 SPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
+P + ++ A L GYR +P NC +++
Sbjct: 1030 TPYPTITNNELLALLKSGYRMDRPGNCSEQM 1060
>UniRef50_P00533 Cluster: Epidermal growth factor receptor
precursor; n=124; root|Rep: Epidermal growth factor
receptor precursor - Homo sapiens (Human)
Length = 1210
Score = 105 bits (252), Expect = 1e-21
Identities = 51/126 (40%), Positives = 76/126 (60%)
Query: 137 LVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDN 196
L++ Q+A G++YL +R VH D+AARN +V +K+TD GLA+ L ++ +
Sbjct: 814 LLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEG 873
Query: 197 ENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRP 256
P+KWMA E++L Y+ SDVWS G+T+WEL T GS P + A+++ + L G R
Sbjct: 874 GKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERL 933
Query: 257 SQPHNC 262
QP C
Sbjct: 934 PQPPIC 939
>UniRef50_UPI0000E4736E Cluster: PREDICTED: similar to src-family
protein tyrosine kinase; n=2; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to src-family protein
tyrosine kinase - Strongylocentrotus purpuratus
Length = 387
Score = 105 bits (251), Expect = 2e-21
Identities = 67/229 (29%), Positives = 112/229 (48%), Gaps = 11/229 (4%)
Query: 38 EGTFGRIYKGVFKKGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLVHANVLTPMAAC 97
EG FG +++GV+ G+ V VKT ++ L H ++ A C
Sbjct: 134 EGKFGEVWQGVWN-GNT--PVAVKTLKERTMSPAAFLAEANVMKK--LRHEGIVQLYAVC 188
Query: 98 AEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQRFV 157
++ ++P+ I + +L+ +L S + L+D+GA +A G+ YL + V
Sbjct: 189 SD--KEPIYIVTELMSNGDLRTYLKSDKCKNTKMTT---LIDMGAHIASGMDYLGSKNVV 243
Query: 158 HADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENRPVKWMAPETLLQNQYSTA 217
H D+AARN +V + +K+ D G A+ L D + + P+KW APE +L +++
Sbjct: 244 HRDLAARNVLVGKGNVVKIADFGRAQ-LMEKDVYVGEEGAKLPLKWTAPEAVLHGRFTIK 302
Query: 218 SDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
SDVWS GI + E+ T G P ++ +V + GYR + +C D L
Sbjct: 303 SDVWSFGILMTEMVTFGGYPYKKMRTREVTKKVANGYRMPKMDHCTDSL 351
>UniRef50_UPI0000E257E1 Cluster: PREDICTED: similar to tyrosine
kinase; n=1; Pan troglodytes|Rep: PREDICTED: similar to
tyrosine kinase - Pan troglodytes
Length = 299
Score = 105 bits (251), Expect = 2e-21
Identities = 56/128 (43%), Positives = 73/128 (57%), Gaps = 2/128 (1%)
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGD 195
EL+D+ QVA G+ YL +Q ++H D+AARN +V E KV D GLAR + D Y L
Sbjct: 136 ELLDIAWQVAEGMCYLELQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVY--LSH 193
Query: 196 NENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYR 255
+ N P KW APE L + YST SDVWS GI L E+ + G P + + ++ GYR
Sbjct: 194 DHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYR 253
Query: 256 PSQPHNCP 263
P CP
Sbjct: 254 MPCPLECP 261
>UniRef50_Q4RXA0 Cluster: Chromosome 11 SCAF14979, whole genome
shotgun sequence; n=5; Euteleostomi|Rep: Chromosome 11
SCAF14979, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 1042
Score = 105 bits (251), Expect = 2e-21
Identities = 68/241 (28%), Positives = 111/241 (46%), Gaps = 8/241 (3%)
Query: 28 SNIRLEILIHEGTFGRIYKGVFK-KGDVYEEVMVKTXXXXXXXXXXXXXXXEGLRLYGLV 86
S I + +I G FG +++GV K +G V +KT E +
Sbjct: 680 SAISKQKVIGVGEFGEVFRGVMKTRGQGEVNVAIKTLKPGYSEKQRLDFLSEASIMGQFS 739
Query: 87 HANVLTPMAACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVAC 146
H N++ + K ++I + L +L G+ +LV + +A
Sbjct: 740 HPNIIHLEGVVTKF--KHIMIVTEYMDNGALDTYLK----GRDGEIPPYQLVGMLRGIAA 793
Query: 147 GLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENR-PVKWMA 205
G+ YL +VH D+AARN +V+ L KV+D GL+R L DD + P++W A
Sbjct: 794 GMQYLSNMSYVHRDLAARNILVNSNLECKVSDFGLSRVLEDDDEGTYTTRGGKIPIRWTA 853
Query: 206 PETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDE 265
PE + ++++ASDVWS GI +WE+ G P ++ +V +N +R P +CP
Sbjct: 854 PEAIAYRKFTSASDVWSFGIVMWEVMAFGERPYWDMSNHEVMKAINEAFRLPAPMDCPSA 913
Query: 266 L 266
+
Sbjct: 914 I 914
>UniRef50_Q9Y1Z0 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 485
Score = 105 bits (251), Expect = 2e-21
Identities = 50/129 (38%), Positives = 70/129 (54%), Gaps = 4/129 (3%)
Query: 138 VDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNE 197
+D V G+ YL Q FVH D+AARN ++ E KV+D GLA+ + +
Sbjct: 326 IDFARDVVKGMVYLESQNFVHRDLAARNVLIAEDNVAKVSDFGLAKS----SSNVKQEGA 381
Query: 198 NRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPS 257
PVKW APE L +N++S +DVWS G+ LWE+ + G P + DV + GYR
Sbjct: 382 KLPVKWTAPEALRENKFSNKTDVWSFGVLLWEIYSYGRVPYPRVPVEDVANHVENGYRME 441
Query: 258 QPHNCPDEL 266
P CPD++
Sbjct: 442 SPDGCPDQI 450
>UniRef50_Q9Y1X9 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 573
Score = 105 bits (251), Expect = 2e-21
Identities = 65/232 (28%), Positives = 110/232 (47%), Gaps = 12/232 (5%)
Query: 39 GTFGRIYKGVF--KKGDVYEEVMVKTXXXXXXX-XXXXXXXXEGLRLYGLVHANVLTPMA 95
GTFG + GV+ K G+ + +K E + L H N++
Sbjct: 295 GTFGTVRLGVYRPKNGEPEVQCALKYLKQSEELPNQKAEILREADAMAALDHCNIVRLFG 354
Query: 96 ACAEEARKPLLIYCCPSHSSNLKRFLSSCRLGQQSAPATRELVDLGAQVACGLSYLHVQR 155
C + P+ + + L +FL + + P + ++++ QV+ G++YL R
Sbjct: 355 ICVGD---PICLVMELARQGPLNKFLRK----RPTFPVIK-ILNMALQVSRGMAYLEEVR 406
Query: 156 FVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYHCLGDNENR-PVKWMAPETLLQNQY 214
FVH D+AARN +V + +K++D G++R + + + R P+KW APE + ++
Sbjct: 407 FVHRDLAARNVLVVDDDNVKISDFGMSRAIGAGSEYYKAETAGRWPLKWYAPECIYYAKF 466
Query: 215 STASDVWSLGITLWELATLGSSPLAELDAADVGAFLNGGYRPSQPHNCPDEL 266
+ SDVWS G+T+WE + G+ P A L D+ L G R P CP +
Sbjct: 467 DSKSDVWSYGVTVWEAFSFGAKPYAGLKGQDIMQMLEGNQRLDSPEKCPQPI 518
>UniRef50_Q16288 Cluster: NT-3 growth factor receptor precursor;
n=49; Euteleostomi|Rep: NT-3 growth factor receptor
precursor - Homo sapiens (Human)
Length = 839
Score = 105 bits (251), Expect = 2e-21
Identities = 50/145 (34%), Positives = 83/145 (57%), Gaps = 14/145 (9%)
Query: 136 ELVDLGAQVACGLSYLHVQRFVHADVAARNCVVDEKLRLKVTDNGLARDLFPDDYH---- 191
+++ + +Q+A G+ YL Q FVH D+A RNC+V L +K+ D G++RD++ DY+
Sbjct: 655 QMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFN 714
Query: 192 ------CL----GDNENRPVKWMAPETLLQNQYSTASDVWSLGITLWELATLGSSPLAEL 241
C+ G + P++WM PE+++ +++T SDVWS G+ LWE+ T G P +L
Sbjct: 715 PSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQL 774
Query: 242 DAADVGAFLNGGYRPSQPHNCPDEL 266
+V + G +P CP E+
Sbjct: 775 SNTEVIECITQGRVLERPRVCPKEV 799
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.319 0.135 0.409
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 283,786,675
Number of Sequences: 1657284
Number of extensions: 10978956
Number of successful extensions: 38568
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 3592
Number of HSP's successfully gapped in prelim test: 4682
Number of HSP's that attempted gapping in prelim test: 28270
Number of HSP's gapped (non-prelim): 9553
length of query: 266
length of database: 575,637,011
effective HSP length: 99
effective length of query: 167
effective length of database: 411,565,895
effective search space: 68731504465
effective search space used: 68731504465
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 71 (32.7 bits)
- SilkBase 1999-2023 -