Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA002660-TA|BGIBMGA002660-PA|IPR001360|Glycoside
hydrolase, family 1
(523 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X07994-1|CAA30801.1| 1927|Homo sapiens protein ( Human mRNA for ... 451 e-126
AY191611-1|AAP12677.1| 1003|Homo sapiens lactase-phlorizin hydro... 451 e-126
M61850-1|AAA59504.1| 1927|Homo sapiens lactase phlorizinhydrolas... 450 e-126
AC011893-3|AAX88924.1| 1927|Homo sapiens unknown protein. 450 e-126
AY358729-1|AAQ89091.1| 567|Homo sapiens KPVW3022 protein. 433 e-121
AJ278964-1|CAC08178.1| 469|Homo sapiens cytosolic beta-glucosid... 386 e-106
BC101829-1|AAI01830.1| 469|Homo sapiens cytosolic beta-glucosid... 384 e-106
AF323990-1|AAL37305.1| 469|Homo sapiens cytosolic beta-glucosid... 384 e-106
AB017913-1|BAB18741.1| 469|Homo sapiens cytosolic beta-glucosid... 384 e-106
AF317840-1|AAG39217.1| 469|Homo sapiens cytosolic beta-glucosid... 384 e-106
AK222963-1|BAD96683.1| 469|Homo sapiens cytosolic beta-glucosid... 380 e-105
AL161898-1|CAH71888.1| 1012|Homo sapiens klotho protein. 305 2e-82
AB009667-2|BAA24941.1| 549|Homo sapiens Klotho protein (KL) pro... 305 2e-82
AB009667-1|BAA24940.1| 1012|Homo sapiens Klotho protein (KL) pro... 305 2e-82
AB005142-1|BAA23382.1| 1012|Homo sapiens klotho protein. 305 2e-82
BC113653-1|AAI13654.1| 1044|Homo sapiens klotho beta protein. 292 2e-78
BC104871-1|AAI04872.1| 1044|Homo sapiens klotho beta protein. 292 2e-78
AB079373-1|BAC56857.1| 1044|Homo sapiens klotho beta like protei... 292 2e-78
Z84483-1|CAC94773.1| 739|Homo sapiens 46H23.1 (Klotho) protein. 217 6e-56
Z92540-2|CAC94767.1| 273|Homo sapiens 179I15.1 (klotho) protein. 181 5e-45
BC033021-1|AAH33021.1| 305|Homo sapiens KLB protein protein. 126 1e-28
BC109377-1|AAI09378.1| 162|Homo sapiens GBA3 protein protein. 93 3e-18
BC029362-1|AAH29362.1| 162|Homo sapiens GBA3 protein protein. 93 3e-18
BC070188-1|AAH70188.1| 162|Homo sapiens GBA3 protein protein. 92 5e-18
U33837-1|AAB41649.1| 4655|Homo sapiens gp330 precursor protein. 35 0.61
AY265358-1|AAP88586.1| 4655|Homo sapiens glycoprotein receptor g... 35 0.61
AY265357-1|AAP88585.1| 4655|Homo sapiens glycoprotein receptor g... 35 0.61
AC007556-2|AAX88965.1| 3881|Homo sapiens unknown protein. 35 0.61
>X07994-1|CAA30801.1| 1927|Homo sapiens protein ( Human mRNA for
lactase-phlorizin hydrolase LPH (EC 3.2.1.23-62). ).
Length = 1927
Score = 451 bits (1111), Expect = e-126
Identities = 211/468 (45%), Positives = 292/468 (62%), Gaps = 7/468 (1%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHLYKRD 83
F ++F++GVS++A QIEGAW+ DGK SIWD+ H VKD + D+A DSYH D
Sbjct: 903 FRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLDAD 962
Query: 84 AEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHWD 143
M+ L V YRFS+SW RI PTG + IN G+ YYN LIN ++ NI PM+T++HWD
Sbjct: 963 LNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFHWD 1022
Query: 144 LPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAPA 203
LPQ LQDIGGW N ++D + YA F+ FGDRVK+W+TFNEPM GYG P
Sbjct: 1023 LPQALQDIGGWENPALIDLFDSYADFCFQTFGDRVKFWMTFNEPMYLAWLGYGSGEFPPG 1082
Query: 204 LNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEPKT-DTQEDRDA 262
+ G A Y H ++KAHA VYH +D++YR KG I ++L ++WAEPK+ D +A
Sbjct: 1083 VKDPGWAPYRIAHTVIKAHARVYHTYDEKYRQEQKGVISLSLSTHWAEPKSPGVPRDVEA 1142
Query: 263 AELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTTEEVEYIKGTA 322
A+ LQ +GW+AHPI+ G+YP + V +S+ Q+ SRLP FT EE +I+ TA
Sbjct: 1143 ADRMLQFSLGWFAHPIF-RNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRATA 1201
Query: 323 DFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESSSTWLKVVPYGFRKLL 382
D F LN Y + ++ + PS+++D + +DP+WPS + + + P+G R+LL
Sbjct: 1202 DVFCLNTYYSRIVQHKTPRLNP-PSYEDDQEMAEEEDPSWPSTAMN---RAAPWGTRRLL 1257
Query: 383 QWITKTYSGYPIIVTENGYADFN-GLDDKTRVSYYSHYLNALLHSIHEDGSVVEGYFAWS 441
WI + Y PI +TENG N +D R+ Y+ Y+N L + DG + GY AWS
Sbjct: 1258 NWIKEEYGDIPIYITENGVGLTNPNTEDTDRIFYHKTYINEALKAYRLDGIDLRGYVAWS 1317
Query: 442 LMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIASRRLP 489
LMDNFEW +GY +FGLY VDF + N+ RTA+ SA+ Y++VI + +P
Sbjct: 1318 LMDNFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVITNNGMP 1365
Score = 436 bits (1073), Expect = e-121
Identities = 213/472 (45%), Positives = 284/472 (60%), Gaps = 9/472 (1%)
Query: 23 KFPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHLYKR 82
+FPE FI+ ++AA QIEGAW DGK SIWD H P V++ + DVA DSYH
Sbjct: 1376 RFPEGFIWSAASAAYQIEGAWRADGKGLSIWDTFSH-TPLRVENDAIGDVACDSYHKIAE 1434
Query: 83 DAEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHW 142
D + LGV YRFS+SW RILP G T INE G+ YY LI+ +L +I P +TIYHW
Sbjct: 1435 DLVTLQNLGVSHYRFSISWSRILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIYHW 1494
Query: 143 DLPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAP 202
DLPQ LQD+GGW N IV + +YA +LF+ GD+VK+WIT NEP +GYG AP
Sbjct: 1495 DLPQTLQDVGGWENETIVQRFKEYADVLFQRLGDKVKFWITLNEPFVIAYQGYGYGTAAP 1554
Query: 203 AL-NRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEPK-TDTQEDR 260
+ NR G A Y+ HNL+KAHA +HL++ YR G I I + S+WAEP+ QED
Sbjct: 1555 GVSNRPGTAPYIVGHNLIKAHAEAWHLYNDVYRASQGGVISITISSDWAEPRDPSNQEDV 1614
Query: 261 DAAELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTTEEVEYIKG 320
+AA Y+Q GW+AHPI+ G+Y + + +S +SRLP+FT E I G
Sbjct: 1615 EAARRYVQFMGGWFAHPIFK-NGDYNEVMKTRIRDRSLAAGLNKSRLPEFTESEKRRING 1673
Query: 321 TADFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESSSTWLKVVPYGFRK 380
T DFFG NHYTT L + +I S D G+ + D +WP +S S WLK+ P+GFR+
Sbjct: 1674 TYDFFGFNHYTTVLAYNLNYAT-AISSFDADRGVASIADRSWP-DSGSFWLKMTPFGFRR 1731
Query: 381 LLQWITKTYSGYPIIVTENGYA--DFNGLDDKTRVSYYSHYLNALLHSIHEDGSVVEGYF 438
+L W+ + Y+ PI VTENG + + L+D R+ Y Y+N L ++ +D + GY
Sbjct: 1732 ILNWLKEEYNDPPIYVTENGVSQREETDLNDTARIYYLRTYINEALKAV-QDKVDLRGYT 1790
Query: 439 AWSLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIASRRLPE 490
WS MDNFEW G+ RFGL+ V++ P+ R K SAK Y+ V+ P+
Sbjct: 1791 VWSAMDNFEWATGFSERFGLHFVNYSDPSLPRIPKASAKFYASVVRCNGFPD 1842
Score = 377 bits (927), Expect = e-104
Identities = 188/467 (40%), Positives = 277/467 (59%), Gaps = 13/467 (2%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDG-SNADVASDSYHLYKR 82
FPE F++G ST A +EG W G+ SIWD + P +G + +VASDSYH
Sbjct: 382 FPEGFLWGASTGAFNVEGGWAEGGRGVSIWDP---RRPLNTTEGQATLEVASDSYHKVAS 438
Query: 83 DAEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHW 142
D ++ L Y+FS+SW RI P G + + G+AYYN LI+ + I PM T++HW
Sbjct: 439 DVALLCGLRAQVYKFSISWSRIFPMGHGSSPSLPGVAYYNKLIDRLQDAGIEPMATLFHW 498
Query: 143 DLPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAP 202
DLPQ LQD GGW N +VD + DYA F FGDRVK W+TF+EP GYG P
Sbjct: 499 DLPQALQDHGGWQNESVVDAFLDYAAFCFSTFGDRVKLWVTFHEPWVMSYAGYGTGQHPP 558
Query: 203 ALNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEP-KTDTQEDRD 261
++ G A + H +LKAHA +H ++ +R +G +GI L+S+WAEP + ED
Sbjct: 559 GISDPGVASFKVAHLVLKAHARTWHHYNSHHRPQQQGHVGIVLNSDWAEPLSPERPEDLR 618
Query: 262 AAELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTTEEVEYIKGT 321
A+E +L +GW+AHP++ +G+YP L + Q +++ + ++LP+FT E + +KG+
Sbjct: 619 ASERFLHFMLGWFAHPVF-VDGDYPATLRTQIQQMNRQCSHPVAQLPEFTEAEKQLLKGS 677
Query: 322 ADFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESSSTWLKVVPYGFRKL 381
ADF GL+HYT+ L++ A + IPS+ G + + WP ++SS+W++VVP+G R+L
Sbjct: 678 ADFLGLSHYTSRLISNAPQNT-CIPSYDTIGGFSQHVNHVWP-QTSSSWIRVVPWGIRRL 735
Query: 382 LQWITKTYS--GYPIIVTENGY---ADFNGLDDKTRVSYYSHYLNALLHSIHEDGSVVEG 436
LQ+++ Y+ PI + NG N DD RV Y++ Y+N +L +I ED V
Sbjct: 736 LQFVSLEYTRGKVPIYLAGNGMPIGESENLFDDSLRVDYFNQYINEVLKAIKEDSVDVRS 795
Query: 437 YFAWSLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVI 483
Y A SL+D FE GY RFGL+ V+F +K+RT + SA ++ +I
Sbjct: 796 YIARSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTSII 842
Score = 60.1 bits (139), Expect = 2e-08
Identities = 41/159 (25%), Positives = 67/159 (42%), Gaps = 16/159 (10%)
Query: 87 VHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHWDLPQ 146
+H + Y+ +SW ++LP G T +E + Y L+ + + PM+ ++H LP
Sbjct: 79 LHASQITHYKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKALKTARLQPMVILHHQTLPA 138
Query: 147 KLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAPALNR 206
D + DYA F +FGD V W TF++ + E P ++
Sbjct: 139 STLR----RTEAFADLFADYATFAFHSFGDLVGIWFTFSDLEEVIKE-------LP--HQ 185
Query: 207 HGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIAL 245
A L T L AH Y ++ + Y GK+ + L
Sbjct: 186 ESRASQLQT--LSDAHRKAYEIYHESY-AFQGGKLSVVL 221
>AY191611-1|AAP12677.1| 1003|Homo sapiens lactase-phlorizin
hydrolase-1 protein.
Length = 1003
Score = 451 bits (1111), Expect = e-126
Identities = 211/468 (45%), Positives = 292/468 (62%), Gaps = 7/468 (1%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHLYKRD 83
F ++F++GVS++A QIEGAW+ DGK SIWD+ H VKD + D+A DSYH D
Sbjct: 335 FRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLDAD 394
Query: 84 AEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHWD 143
M+ L V YRFS+SW RI PTG + IN G+ YYN LIN ++ NI PM+T++HWD
Sbjct: 395 LNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFHWD 454
Query: 144 LPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAPA 203
LPQ LQDIGGW N ++D + YA F+ FGDRVK+W+TFNEPM GYG P
Sbjct: 455 LPQALQDIGGWENPALIDLFDSYADFCFQTFGDRVKFWMTFNEPMYLAWLGYGSGEFPPG 514
Query: 204 LNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEPKT-DTQEDRDA 262
+ G A Y H ++KAHA VYH +D++YR KG I ++L ++WAEPK+ D +A
Sbjct: 515 VKDPGWAPYRIAHTVIKAHARVYHTYDEKYRQEQKGVISLSLSTHWAEPKSPGVPRDVEA 574
Query: 263 AELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTTEEVEYIKGTA 322
A+ LQ +GW+AHPI+ G+YP + V +S+ Q+ SRLP FT EE +I+ TA
Sbjct: 575 ADRMLQFSLGWFAHPIF-RNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRATA 633
Query: 323 DFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESSSTWLKVVPYGFRKLL 382
D F LN Y + ++ + PS+++D + +DP+WPS + + + P+G R+LL
Sbjct: 634 DVFCLNTYYSRIVQHKTPRLNP-PSYEDDQEMAEEEDPSWPSTAMN---RAAPWGTRRLL 689
Query: 383 QWITKTYSGYPIIVTENGYADFN-GLDDKTRVSYYSHYLNALLHSIHEDGSVVEGYFAWS 441
WI + Y PI +TENG N +D R+ Y+ Y+N L + DG + GY AWS
Sbjct: 690 NWIKEEYGDIPIYITENGVGLTNPNTEDTDRIFYHKTYINEALKAYRLDGIDLRGYVAWS 749
Query: 442 LMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIASRRLP 489
LMDNFEW +GY +FGLY VDF + N+ RTA+ SA+ Y++VI + +P
Sbjct: 750 LMDNFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVITNNGMP 797
Score = 206 bits (502), Expect = 2e-52
Identities = 105/274 (38%), Positives = 169/274 (61%), Gaps = 9/274 (3%)
Query: 216 HNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEPKT-DTQEDRDAAELYLQTHVGWY 274
H +LKAHA +H ++ +R +G +GI L+S+WAEP + + ED A+E +L +GW+
Sbjct: 4 HLVLKAHARTWHHYNSHHRPQQQGHVGIVLNSDWAEPLSPERPEDLRASERFLHFMLGWF 63
Query: 275 AHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTTEEVEYIKGTADFFGLNHYTTYL 334
AHP++ +G+YP L + Q +++ + ++LP+FT E + +KG+ADF GL+HYT+ L
Sbjct: 64 AHPVF-VDGDYPATLRTQIQQMNRQCSHPVAQLPEFTEAEKQLLKGSADFLGLSHYTSRL 122
Query: 335 LTMADKEVGSIPSHQNDVGIVRVQDPNWPSESSSTWLKVVPYGFRKLLQWITKTYSG--Y 392
++ A + IPS+ G + + WP ++SS+W++VVP+G R+LLQ+++ Y+
Sbjct: 123 ISNAPQNT-CIPSYDTIGGFSQHVNHVWP-QTSSSWIRVVPWGIRRLLQFVSLEYTRGKV 180
Query: 393 PIIVTENGYA---DFNGLDDKTRVSYYSHYLNALLHSIHEDGSVVEGYFAWSLMDNFEWD 449
PI + NG N DD RV Y++ Y+N +L +I ED V Y A SL+D FE
Sbjct: 181 PIYLAGNGMPIGESENLFDDSLRVDYFNQYINEVLKAIKEDSVDVRSYIARSLIDGFEGP 240
Query: 450 DGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVI 483
GY RFGL+ V+F +K+RT + SA ++ +I
Sbjct: 241 SGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTSII 274
Score = 206 bits (502), Expect = 2e-52
Identities = 97/193 (50%), Positives = 120/193 (62%), Gaps = 6/193 (3%)
Query: 23 KFPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHLYKR 82
+FPE FI+ ++AA QIEGAW DGK SIWD H P V++ + DVA DSYH
Sbjct: 808 RFPEGFIWSAASAAYQIEGAWRADGKGLSIWDTFSH-TPLRVENDAIGDVACDSYHKIAE 866
Query: 83 DAEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHW 142
D + LGV YRFS+SW RILP G T INE G+ YY LI+ +L +I P +TIYHW
Sbjct: 867 DLVTLQNLGVSHYRFSISWSRILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIYHW 926
Query: 143 DLPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAP 202
DLPQ LQD+GGW N IV + +YA +LF+ GD+VK+WIT NEP +GYG AP
Sbjct: 927 DLPQTLQDVGGWENETIVQRFKEYADVLFQRLGDKVKFWITLNEPFVIAYQGYGYGTAAP 986
Query: 203 ALNRHGHAEYLCT 215
H +CT
Sbjct: 987 V-----HGRLVCT 994
>M61850-1|AAA59504.1| 1927|Homo sapiens lactase phlorizinhydrolase
protein.
Length = 1927
Score = 450 bits (1109), Expect = e-126
Identities = 211/468 (45%), Positives = 292/468 (62%), Gaps = 7/468 (1%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHLYKRD 83
F ++F++GVS++A QIEGAW+ DGK SIWD+ H VKD + D+A DSYH D
Sbjct: 903 FRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLDAD 962
Query: 84 AEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHWD 143
M+ L V YRFS+SW RI PTG + IN G+ YYN LIN ++ NI PM+T++HWD
Sbjct: 963 LNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFHWD 1022
Query: 144 LPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAPA 203
LPQ LQDIGGW N ++D + YA F+ FGDRVK+W+TFNEPM GYG P
Sbjct: 1023 LPQALQDIGGWENPALIDLFDSYADFCFQTFGDRVKFWMTFNEPMYLAWLGYGSGEFPPG 1082
Query: 204 LNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEPKT-DTQEDRDA 262
+ G A Y H ++KAHA VYH +D++YR KG I ++L ++WAEPK+ D +A
Sbjct: 1083 VKDPGWAPYRIAHAVIKAHARVYHTYDEKYRQEQKGVISLSLSTHWAEPKSPGVPRDVEA 1142
Query: 263 AELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTTEEVEYIKGTA 322
A+ LQ +GW+AHPI+ G+YP + V +S+ Q+ SRLP FT EE +I+ TA
Sbjct: 1143 ADRMLQFSLGWFAHPIF-RNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRATA 1201
Query: 323 DFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESSSTWLKVVPYGFRKLL 382
D F LN Y + ++ + PS+++D + +DP+WPS + + + P+G R+LL
Sbjct: 1202 DVFCLNTYYSRIVQHKTPRLNP-PSYEDDQEMAEEEDPSWPSTAMN---RAAPWGTRRLL 1257
Query: 383 QWITKTYSGYPIIVTENGYADFN-GLDDKTRVSYYSHYLNALLHSIHEDGSVVEGYFAWS 441
WI + Y PI +TENG N +D R+ Y+ Y+N L + DG + GY AWS
Sbjct: 1258 NWIKEEYGDIPIYITENGVGLTNPNTEDTDRIFYHKTYINEALKAYRLDGIDLRGYVAWS 1317
Query: 442 LMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIASRRLP 489
LMDNFEW +GY +FGLY VDF + N+ RTA+ SA+ Y++VI + +P
Sbjct: 1318 LMDNFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVITNNGMP 1365
Score = 436 bits (1074), Expect = e-121
Identities = 213/472 (45%), Positives = 284/472 (60%), Gaps = 9/472 (1%)
Query: 23 KFPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHLYKR 82
+FPE FI+ ++AA QIEGAW DGK SIWD H P V++ + DVA DSYH
Sbjct: 1376 RFPEGFIWSAASAAYQIEGAWRADGKGLSIWDTFSH-TPLRVENDAIGDVACDSYHKIAE 1434
Query: 83 DAEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHW 142
D + LGV YRFS+SW RILP G T INE G+ YY LI+ +L +I P +TIYHW
Sbjct: 1435 DLVTLQNLGVSHYRFSISWSRILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIYHW 1494
Query: 143 DLPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAP 202
DLPQ LQD+GGW N IV + +YA +LF+ GD+VK+WIT NEP +GYG AP
Sbjct: 1495 DLPQTLQDVGGWENETIVQRFKEYADVLFQRLGDKVKFWITLNEPFVIAYQGYGYGTAAP 1554
Query: 203 AL-NRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEPK-TDTQEDR 260
+ NR G A Y+ HNL+KAHA +HL++ YR G I I + S+WAEP+ QED
Sbjct: 1555 GVSNRPGTAPYIVGHNLIKAHAEAWHLYNDVYRASQGGVISITISSDWAEPRDPSNQEDV 1614
Query: 261 DAAELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTTEEVEYIKG 320
+AA Y+Q GW+AHPI+ G+Y + + +S +SRLP+FT E I G
Sbjct: 1615 EAARRYVQFMGGWFAHPIFK-NGDYSEVMKTRIRDRSLAAGLNKSRLPEFTESEKRRING 1673
Query: 321 TADFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESSSTWLKVVPYGFRK 380
T DFFG NHYTT L + +I S D G+ + D +WP +S S WLK+ P+GFR+
Sbjct: 1674 TYDFFGFNHYTTVLAYNLNYAT-AISSFDADRGVASIADRSWP-DSGSFWLKMTPFGFRR 1731
Query: 381 LLQWITKTYSGYPIIVTENGYA--DFNGLDDKTRVSYYSHYLNALLHSIHEDGSVVEGYF 438
+L W+ + Y+ PI VTENG + + L+D R+ Y Y+N L ++ +D + GY
Sbjct: 1732 ILNWLKEEYNDPPIYVTENGVSQREETDLNDTARIYYLRTYINEALKAV-QDKVDLRGYT 1790
Query: 439 AWSLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIASRRLPE 490
WS MDNFEW G+ RFGL+ V++ P+ R K SAK Y+ V+ P+
Sbjct: 1791 VWSAMDNFEWATGFSERFGLHFVNYSDPSLPRIPKASAKFYASVVRCNGFPD 1842
Score = 377 bits (927), Expect = e-104
Identities = 188/467 (40%), Positives = 277/467 (59%), Gaps = 13/467 (2%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDG-SNADVASDSYHLYKR 82
FPE F++G ST A +EG W G+ SIWD + P +G + +VASDSYH
Sbjct: 382 FPEGFLWGASTGAFNVEGGWAEGGRGVSIWDP---RRPLNTTEGQATLEVASDSYHKVAS 438
Query: 83 DAEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHW 142
D ++ L Y+FS+SW RI P G + + G+AYYN LI+ + I PM T++HW
Sbjct: 439 DVALLCGLRAQVYKFSISWSRIFPMGHGSSPSLPGVAYYNKLIDRLQDAGIEPMATLFHW 498
Query: 143 DLPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAP 202
DLPQ LQD GGW N +VD + DYA F FGDRVK W+TF+EP GYG P
Sbjct: 499 DLPQALQDHGGWQNESVVDAFLDYAAFCFSTFGDRVKLWVTFHEPWVMSYAGYGTGQHPP 558
Query: 203 ALNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEP-KTDTQEDRD 261
++ G A + H +LKAHA +H ++ +R +G +GI L+S+WAEP + ED
Sbjct: 559 GISDPGVASFKVAHLVLKAHARTWHHYNSHHRPQQQGHVGIVLNSDWAEPLSPERPEDLR 618
Query: 262 AAELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTTEEVEYIKGT 321
A+E +L +GW+AHP++ +G+YP L + Q +++ + ++LP+FT E + +KG+
Sbjct: 619 ASERFLHFMLGWFAHPVF-VDGDYPATLRTQIQQMNRQCSHPVAQLPEFTEAEKQLLKGS 677
Query: 322 ADFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESSSTWLKVVPYGFRKL 381
ADF GL+HYT+ L++ A + IPS+ G + + WP ++SS+W++VVP+G R+L
Sbjct: 678 ADFLGLSHYTSRLISNAPQNT-CIPSYDTIGGFSQHVNHVWP-QTSSSWIRVVPWGIRRL 735
Query: 382 LQWITKTYS--GYPIIVTENGY---ADFNGLDDKTRVSYYSHYLNALLHSIHEDGSVVEG 436
LQ+++ Y+ PI + NG N DD RV Y++ Y+N +L +I ED V
Sbjct: 736 LQFVSLEYTRGKVPIYLAGNGMPIGESENLFDDSLRVDYFNQYINEVLKAIKEDSVDVRS 795
Query: 437 YFAWSLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVI 483
Y A SL+D FE GY RFGL+ V+F +K+RT + SA ++ +I
Sbjct: 796 YIARSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTSII 842
Score = 60.5 bits (140), Expect = 1e-08
Identities = 42/159 (26%), Positives = 67/159 (42%), Gaps = 16/159 (10%)
Query: 87 VHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHWDLPQ 146
+H + Y+ +SW ++LP G T +E + Y L+ + + PM+ ++H LP
Sbjct: 79 LHASQITHYKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKALKTARLQPMVILHHQTLPA 138
Query: 147 KLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAPALNR 206
D + DYA F +FGD V W TF++ + E P ++
Sbjct: 139 STLR----RTEAFADLFADYATFAFHSFGDLVGIWFTFSDLEEVIKE-------LP--HQ 185
Query: 207 HGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIAL 245
A L T L AH Y ++ + Y GK+ I L
Sbjct: 186 ESRASQLQT--LSDAHRKAYEIYHESY-AFQGGKLSIVL 221
>AC011893-3|AAX88924.1| 1927|Homo sapiens unknown protein.
Length = 1927
Score = 450 bits (1109), Expect = e-126
Identities = 211/468 (45%), Positives = 292/468 (62%), Gaps = 7/468 (1%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHLYKRD 83
F ++F++GVS++A QIEGAW+ DGK SIWD+ H VKD + D+A DSYH D
Sbjct: 903 FRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLDAD 962
Query: 84 AEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHWD 143
M+ L V YRFS+SW RI PTG + IN G+ YYN LIN ++ NI PM+T++HWD
Sbjct: 963 LNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFHWD 1022
Query: 144 LPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAPA 203
LPQ LQDIGGW N ++D + YA F+ FGDRVK+W+TFNEPM GYG P
Sbjct: 1023 LPQALQDIGGWENPALIDLFDSYADFCFQTFGDRVKFWMTFNEPMYLAWLGYGSGEFPPG 1082
Query: 204 LNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEPKT-DTQEDRDA 262
+ G A Y H ++KAHA VYH +D++YR KG I ++L ++WAEPK+ D +A
Sbjct: 1083 VKDPGWAPYRIAHAVIKAHARVYHTYDEKYRQEQKGVISLSLSTHWAEPKSPGVPRDVEA 1142
Query: 263 AELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTTEEVEYIKGTA 322
A+ LQ +GW+AHPI+ G+YP + V +S+ Q+ SRLP FT EE +I+ TA
Sbjct: 1143 ADRMLQFSLGWFAHPIF-RNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRATA 1201
Query: 323 DFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESSSTWLKVVPYGFRKLL 382
D F LN Y + ++ + PS+++D + +DP+WPS + + + P+G R+LL
Sbjct: 1202 DVFCLNTYYSRIVQHKTPRLNP-PSYEDDQEMAEEEDPSWPSTAMN---RAAPWGTRRLL 1257
Query: 383 QWITKTYSGYPIIVTENGYADFN-GLDDKTRVSYYSHYLNALLHSIHEDGSVVEGYFAWS 441
WI + Y PI +TENG N +D R+ Y+ Y+N L + DG + GY AWS
Sbjct: 1258 NWIKEEYGDIPIYITENGVGLTNPNTEDTDRIFYHKTYINEALKAYRLDGIDLRGYVAWS 1317
Query: 442 LMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIASRRLP 489
LMDNFEW +GY +FGLY VDF + N+ RTA+ SA+ Y++VI + +P
Sbjct: 1318 LMDNFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVITNNGMP 1365
Score = 436 bits (1073), Expect = e-121
Identities = 213/472 (45%), Positives = 284/472 (60%), Gaps = 9/472 (1%)
Query: 23 KFPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHLYKR 82
+FPE FI+ ++AA QIEGAW DGK SIWD H P V++ + DVA DSYH
Sbjct: 1376 RFPEGFIWSAASAAYQIEGAWRADGKGLSIWDTFSH-TPLRVENDAIGDVACDSYHKIAE 1434
Query: 83 DAEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHW 142
D + LGV YRFS+SW RILP G T INE G+ YY LI+ +L +I P +TIYHW
Sbjct: 1435 DLVTLQNLGVSHYRFSISWSRILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIYHW 1494
Query: 143 DLPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAP 202
DLPQ LQD+GGW N IV + +YA +LF+ GD+VK+WIT NEP +GYG AP
Sbjct: 1495 DLPQTLQDVGGWENETIVQRFKEYADVLFQRLGDKVKFWITLNEPFVIAYQGYGYGTAAP 1554
Query: 203 AL-NRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEPK-TDTQEDR 260
+ NR G A Y+ HNL+KAHA +HL++ YR G I I + S+WAEP+ QED
Sbjct: 1555 GVSNRPGTAPYIVGHNLIKAHAEAWHLYNDVYRASQGGVISITISSDWAEPRDPSNQEDV 1614
Query: 261 DAAELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTTEEVEYIKG 320
+AA Y+Q GW+AHPI+ G+Y + + +S +SRLP+FT E I G
Sbjct: 1615 EAARRYVQFMGGWFAHPIFK-NGDYNEVMKTRIRDRSLAAGLNKSRLPEFTESEKRRING 1673
Query: 321 TADFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESSSTWLKVVPYGFRK 380
T DFFG NHYTT L + +I S D G+ + D +WP +S S WLK+ P+GFR+
Sbjct: 1674 TYDFFGFNHYTTVLAYNLNYAT-AISSFDADRGVASIADRSWP-DSGSFWLKMTPFGFRR 1731
Query: 381 LLQWITKTYSGYPIIVTENGYA--DFNGLDDKTRVSYYSHYLNALLHSIHEDGSVVEGYF 438
+L W+ + Y+ PI VTENG + + L+D R+ Y Y+N L ++ +D + GY
Sbjct: 1732 ILNWLKEEYNDPPIYVTENGVSQREETDLNDTARIYYLRTYINEALKAV-QDKVDLRGYT 1790
Query: 439 AWSLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIASRRLPE 490
WS MDNFEW G+ RFGL+ V++ P+ R K SAK Y+ V+ P+
Sbjct: 1791 VWSAMDNFEWATGFSERFGLHFVNYSDPSLPRIPKASAKFYASVVRCNGFPD 1842
Score = 377 bits (927), Expect = e-104
Identities = 188/467 (40%), Positives = 277/467 (59%), Gaps = 13/467 (2%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDG-SNADVASDSYHLYKR 82
FPE F++G ST A +EG W G+ SIWD + P +G + +VASDSYH
Sbjct: 382 FPEGFLWGASTGAFNVEGGWAEGGRGVSIWDP---RRPLNTTEGQATLEVASDSYHKVAS 438
Query: 83 DAEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHW 142
D ++ L Y+FS+SW RI P G + + G+AYYN LI+ + I PM T++HW
Sbjct: 439 DVALLCGLRAQVYKFSISWSRIFPMGHGSSPSLPGVAYYNKLIDRLQDAGIEPMATLFHW 498
Query: 143 DLPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAP 202
DLPQ LQD GGW N +VD + DYA F FGDRVK W+TF+EP GYG P
Sbjct: 499 DLPQALQDHGGWQNESVVDAFLDYAAFCFSTFGDRVKLWVTFHEPWVMSYAGYGTGQHPP 558
Query: 203 ALNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEP-KTDTQEDRD 261
++ G A + H +LKAHA +H ++ +R +G +GI L+S+WAEP + ED
Sbjct: 559 GISDPGVASFKVAHLVLKAHARTWHHYNSHHRPQQQGHVGIVLNSDWAEPLSPERPEDLR 618
Query: 262 AAELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTTEEVEYIKGT 321
A+E +L +GW+AHP++ +G+YP L + Q +++ + ++LP+FT E + +KG+
Sbjct: 619 ASERFLHFMLGWFAHPVF-VDGDYPATLRTQIQQMNRQCSHPVAQLPEFTEAEKQLLKGS 677
Query: 322 ADFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESSSTWLKVVPYGFRKL 381
ADF GL+HYT+ L++ A + IPS+ G + + WP ++SS+W++VVP+G R+L
Sbjct: 678 ADFLGLSHYTSRLISNAPQNT-CIPSYDTIGGFSQHVNHVWP-QTSSSWIRVVPWGIRRL 735
Query: 382 LQWITKTYS--GYPIIVTENGY---ADFNGLDDKTRVSYYSHYLNALLHSIHEDGSVVEG 436
LQ+++ Y+ PI + NG N DD RV Y++ Y+N +L +I ED V
Sbjct: 736 LQFVSLEYTRGKVPIYLAGNGMPIGESENLFDDSLRVDYFNQYINEVLKAIKEDSVDVRS 795
Query: 437 YFAWSLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVI 483
Y A SL+D FE GY RFGL+ V+F +K+RT + SA ++ +I
Sbjct: 796 YIARSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTSII 842
Score = 60.1 bits (139), Expect = 2e-08
Identities = 41/159 (25%), Positives = 67/159 (42%), Gaps = 16/159 (10%)
Query: 87 VHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHWDLPQ 146
+H + Y+ +SW ++LP G T +E + Y L+ + + PM+ ++H LP
Sbjct: 79 LHASQITHYKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKALKTARLQPMVILHHQTLPA 138
Query: 147 KLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAPALNR 206
D + DYA F +FGD V W TF++ + E P ++
Sbjct: 139 STLR----RTEAFADLFADYATFAFHSFGDLVGIWFTFSDLEEVIKE-------LP--HQ 185
Query: 207 HGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIAL 245
A L T L AH Y ++ + Y GK+ + L
Sbjct: 186 ESRASQLQT--LSDAHRKAYEIYHESY-AFQGGKLSVVL 221
>AY358729-1|AAQ89091.1| 567|Homo sapiens KPVW3022 protein.
Length = 567
Score = 433 bits (1067), Expect = e-121
Identities = 210/493 (42%), Positives = 301/493 (61%), Gaps = 13/493 (2%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHLYKRD 83
FP F +GV ++A Q EGAW+ DGK SIWD H V ADVA D Y+ + D
Sbjct: 37 FPLGFSWGVGSSAYQTEGAWDQDGKGPSIWDVFTHSGKGKVLGNETADVACDGYYKVQED 96
Query: 84 AEMVHELGVDTYRFSVSWPRILPTGLTNE-INELGIAYYNNLINEILKYNITPMITIYHW 142
++ EL V+ YRFS+SWPR+LPTG+ E +N+ GI +Y++LI+ +L NITP++T++HW
Sbjct: 97 IILLRELHVNHYRFSLSWPRLLPTGIRAEQVNKKGIEFYSDLIDALLSSNITPIVTLHHW 156
Query: 143 DLPQKLQ-DIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRA 201
DLPQ LQ GGW N + +Y+ DYA + F+ FGDRVK+WITF++P +GY + A
Sbjct: 157 DLPQLLQVKYGGWQNVSMANYFRDYANLCFEAFGDRVKHWITFSDPRAMAEKGYETGHHA 216
Query: 202 PALNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEP-KTDTQEDR 260
P L G Y H+++KAHA +H ++ +R+ +G +GI+L+ +W EP +D
Sbjct: 217 PGLKLRGTGLYKAAHHIIKAHAKTWHSYNTTWRSKQQGLVGISLNCDWGEPVDISNPKDL 276
Query: 261 DAAELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTTEEVEYIKG 320
+AAE YLQ +GW+A+PIY+ G+YP + + +KS EQ SRLP F+ +E YIKG
Sbjct: 277 EAAERYLQFCLGWFANPIYA--GDYPQVMKDYIGRKSAEQGLEMSRLPVFSLQEKSYIKG 334
Query: 321 TADFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESSSTWLKVVPYGFRK 380
T+DF GL H+TT +T + PS+QND ++ + DPNWP + S WL VP+GFR+
Sbjct: 335 TSDFLGLGHFTTRYITERNYPSRQGPSYQNDRDLIELVDPNWP-DLGSKWLYSVPWGFRR 393
Query: 381 LLQWITKTYSGYPIIVTENGYAD---FNGLDDKTRVSYYSHYLNALLHSIHEDGSVVEGY 437
LL + Y PI V ENG + L D+ R+ Y Y+N +L +I +DG+ ++GY
Sbjct: 394 LLNFAQTQYGDPPIYVMENGASQKFHCTQLCDEWRIQYLKGYINEMLKAI-KDGANIKGY 452
Query: 438 FAWSLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIASRRLPEDYNPDDF 497
+WSL+D FEW+ GY R+G Y V+F NK R K S + Y K+I + P NP +
Sbjct: 453 TSWSLLDKFEWEKGYSDRYGFYYVEFNDRNKPRYPKASVQYYKKIIIANGFP---NPREV 509
Query: 498 SAFNSAGSHFCSI 510
++ CSI
Sbjct: 510 ESWYLKALETCSI 522
>AJ278964-1|CAC08178.1| 469|Homo sapiens cytosolic beta-glucosidase
protein.
Length = 469
Score = 386 bits (949), Expect = e-106
Identities = 191/468 (40%), Positives = 277/468 (59%), Gaps = 8/468 (1%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHLYKRD 83
FP F + +TAA Q+EG W+ DGK +WD H+ E V DVA SY L++ D
Sbjct: 3 FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWEED 62
Query: 84 AEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHWD 143
+ + +LG+ YRFS+SW R+LP G T IN+ GI YYN +I+++LK +TP++T+YH+D
Sbjct: 63 LKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVTLYHFD 122
Query: 144 LPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAPA 203
LPQ L+D GGW + I++ + YA+ F FGDRVK WIT NE + Y P
Sbjct: 123 LPQTLEDQGGWLSEAIIESFDKYAQFCFSTFGDRVKQWITINEANVLSVMSYDLGMFPPG 182
Query: 204 LNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEP-KTDTQEDRDA 262
+ G Y HNL+KAHA +H +D +R KG + ++L + W EP ++ D++A
Sbjct: 183 IPHFGTGGYQAAHNLIKAHARSWHSYDSLFRKKQKGMVSLSLFAVWLEPADPNSVSDQEA 242
Query: 263 AELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTTEEVEYIKGTA 322
A+ + H+ +A PI+ +G+YP + + S++Q + SRLP+FT EE + IKGTA
Sbjct: 243 AKRAITFHLDLFAKPIF-IDGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEEKKMIKGTA 301
Query: 323 DFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESSSTWLKVVPYGFRKLL 382
DFF + +YTT L+ + + G + + Q D I DP+W + W+ VVP+G KLL
Sbjct: 302 DFFAVQYYTTRLIKYQENKKGELGTLQ-DAEIEFFPDPSW---KNVDWIYVVPWGVCKLL 357
Query: 383 QWITKTYSGYPIIVTENGY--ADFNGLDDKTRVSYYSHYLNALLHSIHEDGSVVEGYFAW 440
++I TY+ I +TENG+ +D LDD R Y+ L +I D ++ Y AW
Sbjct: 358 KYIKDTYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKVNLQVYCAW 417
Query: 441 SLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIASRRL 488
SL+DNFEW+ GY SRFGL+ VDFE P + R SAK Y+K+I + L
Sbjct: 418 SLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGL 465
>BC101829-1|AAI01830.1| 469|Homo sapiens cytosolic beta-glucosidase
protein.
Length = 469
Score = 384 bits (946), Expect = e-106
Identities = 191/468 (40%), Positives = 276/468 (58%), Gaps = 8/468 (1%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHLYKRD 83
FP F + +TAA Q+EG W+ DGK +WD H+ E V DVA SY L++ D
Sbjct: 3 FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWEED 62
Query: 84 AEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHWD 143
+ + +LG+ YRFS+SW R+LP G T IN+ GI YYN +I+++LK +TP++T+YH+D
Sbjct: 63 LKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVTLYHFD 122
Query: 144 LPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAPA 203
LPQ L+D GGW + I++ + YA+ F FGDRVK WIT NE + Y P
Sbjct: 123 LPQTLEDQGGWLSEAIIESFDKYAQFCFSTFGDRVKQWITINEANVLSVMSYDLGMFPPG 182
Query: 204 LNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEP-KTDTQEDRDA 262
+ G Y HNL+KAHA +H +D +R KG + ++L + W EP ++ D++A
Sbjct: 183 IPHFGTGGYQAAHNLIKAHARSWHSYDSLFRKKQKGMVSLSLFAVWLEPADPNSVSDQEA 242
Query: 263 AELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTTEEVEYIKGTA 322
A+ + H+ +A PI+ +G+YP + + S++Q + SRLP+FT EE + IKGTA
Sbjct: 243 AKRAITFHLDLFAKPIF-IDGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEEKKMIKGTA 301
Query: 323 DFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESSSTWLKVVPYGFRKLL 382
DFF + +YTT L+ + + G + Q D I DP+W + W+ VVP+G KLL
Sbjct: 302 DFFAVQYYTTRLIKYQENKKGELGILQ-DAEIEFFPDPSW---KNVDWIYVVPWGVCKLL 357
Query: 383 QWITKTYSGYPIIVTENGY--ADFNGLDDKTRVSYYSHYLNALLHSIHEDGSVVEGYFAW 440
++I TY+ I +TENG+ +D LDD R Y+ L +I D ++ Y AW
Sbjct: 358 KYIKDTYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKVNLQVYCAW 417
Query: 441 SLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIASRRL 488
SL+DNFEW+ GY SRFGL+ VDFE P + R SAK Y+K+I + L
Sbjct: 418 SLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGL 465
>AF323990-1|AAL37305.1| 469|Homo sapiens cytosolic beta-glucosidase
protein.
Length = 469
Score = 384 bits (946), Expect = e-106
Identities = 191/468 (40%), Positives = 276/468 (58%), Gaps = 8/468 (1%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHLYKRD 83
FP F + +TAA Q+EG W+ DGK +WD H+ E V DVA SY L++ D
Sbjct: 3 FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWEED 62
Query: 84 AEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHWD 143
+ + +LG+ YRFS+SW R+LP G T IN+ GI YYN +I+++LK +TP++T+YH+D
Sbjct: 63 LKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVTLYHFD 122
Query: 144 LPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAPA 203
LPQ L+D GGW + I++ + YA+ F FGDRVK WIT NE + Y P
Sbjct: 123 LPQTLEDQGGWLSEAIIESFDKYAQFCFSTFGDRVKQWITINEANVLSVMSYDLGMFPPG 182
Query: 204 LNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEP-KTDTQEDRDA 262
+ G Y HNL+KAHA +H +D +R KG + ++L + W EP ++ D++A
Sbjct: 183 IPHFGTGGYQAAHNLIKAHARSWHSYDSLFRKKQKGMVSLSLFAVWLEPADPNSVSDQEA 242
Query: 263 AELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTTEEVEYIKGTA 322
A+ + H+ +A PI+ +G+YP + + S++Q + SRLP+FT EE + IKGTA
Sbjct: 243 AKRAITFHLDLFAKPIF-IDGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEEKKMIKGTA 301
Query: 323 DFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESSSTWLKVVPYGFRKLL 382
DFF + +YTT L+ + + G + Q D I DP+W + W+ VVP+G KLL
Sbjct: 302 DFFAVQYYTTRLIKYQENKKGELGILQ-DAEIEFFPDPSW---KNVDWIYVVPWGVCKLL 357
Query: 383 QWITKTYSGYPIIVTENGY--ADFNGLDDKTRVSYYSHYLNALLHSIHEDGSVVEGYFAW 440
++I TY+ I +TENG+ +D LDD R Y+ L +I D ++ Y AW
Sbjct: 358 KYIKDTYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKVNLQVYCAW 417
Query: 441 SLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIASRRL 488
SL+DNFEW+ GY SRFGL+ VDFE P + R SAK Y+K+I + L
Sbjct: 418 SLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGL 465
>AB017913-1|BAB18741.1| 469|Homo sapiens cytosolic
beta-glucosidase-like protein-1 protein.
Length = 469
Score = 384 bits (946), Expect = e-106
Identities = 191/468 (40%), Positives = 276/468 (58%), Gaps = 8/468 (1%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHLYKRD 83
FP F + +TAA Q+EG W+ DGK +WD H+ E V DVA SY L++ D
Sbjct: 3 FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWEED 62
Query: 84 AEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHWD 143
+ + +LG+ YRFS+SW R+LP G T IN+ GI YYN +I+++LK +TP++T+YH+D
Sbjct: 63 LKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVTLYHFD 122
Query: 144 LPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAPA 203
LPQ L+D GGW + I++ + YA+ F FGDRVK WIT NE + Y P
Sbjct: 123 LPQTLEDQGGWLSEAIIESFDKYAQFCFSTFGDRVKQWITINEANVLSVMSYDLGMFPPG 182
Query: 204 LNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEP-KTDTQEDRDA 262
+ G Y HNL+KAHA +H +D +R KG + ++L + W EP ++ D++A
Sbjct: 183 IPHFGTGGYQAAHNLIKAHARSWHSYDSLFRKKQKGMVSLSLFAVWLEPADPNSVSDQEA 242
Query: 263 AELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTTEEVEYIKGTA 322
A+ + H+ +A PI+ +G+YP + + S++Q + SRLP+FT EE + IKGTA
Sbjct: 243 AKRAITFHLDLFAKPIF-IDGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEEKKMIKGTA 301
Query: 323 DFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESSSTWLKVVPYGFRKLL 382
DFF + +YTT L+ + + G + Q D I DP+W + W+ VVP+G KLL
Sbjct: 302 DFFAVQYYTTRLIKYQENKKGELGILQ-DAEIEFFPDPSW---KNVDWIYVVPWGVCKLL 357
Query: 383 QWITKTYSGYPIIVTENGY--ADFNGLDDKTRVSYYSHYLNALLHSIHEDGSVVEGYFAW 440
++I TY+ I +TENG+ +D LDD R Y+ L +I D ++ Y AW
Sbjct: 358 KYIKDTYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKVNLQVYCAW 417
Query: 441 SLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIASRRL 488
SL+DNFEW+ GY SRFGL+ VDFE P + R SAK Y+K+I + L
Sbjct: 418 SLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGL 465
>AF317840-1|AAG39217.1| 469|Homo sapiens cytosolic beta-glucosidase
protein.
Length = 469
Score = 384 bits (945), Expect = e-106
Identities = 191/468 (40%), Positives = 276/468 (58%), Gaps = 8/468 (1%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHLYKRD 83
FP F + +TAA Q+EG W+ DGK +WD H+ E V DVA SY L++ D
Sbjct: 3 FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWEED 62
Query: 84 AEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHWD 143
+ + +LG+ YRFS+SW R+LP G T IN+ GI YYN +I+++LK +TP++T+YH+D
Sbjct: 63 LKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVTLYHFD 122
Query: 144 LPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAPA 203
LPQ L+D GGW + I++ + YA+ F FGDRVK WIT NE + Y P
Sbjct: 123 LPQTLEDQGGWWSEAIIESFDKYAQFCFSTFGDRVKQWITINEANVLSVMSYDLGMFPPG 182
Query: 204 LNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEP-KTDTQEDRDA 262
+ G Y HNL+KAHA +H +D +R KG + ++L + W EP ++ D++A
Sbjct: 183 IPHFGTGGYQAAHNLIKAHARSWHSYDSLFRKKQKGMVSLSLFAVWLEPADPNSVSDQEA 242
Query: 263 AELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTTEEVEYIKGTA 322
A+ + H+ +A PI+ +G+YP + + S++Q + SRLP+FT EE + IKGTA
Sbjct: 243 AKRAITFHLDLFAKPIF-IDGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEEKKMIKGTA 301
Query: 323 DFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESSSTWLKVVPYGFRKLL 382
DFF + +YTT L+ + + G + Q D I DP+W + W+ VVP+G KLL
Sbjct: 302 DFFAVQYYTTRLIKYQENKKGELGILQ-DAEIEFFPDPSW---KNVDWIYVVPWGVCKLL 357
Query: 383 QWITKTYSGYPIIVTENGY--ADFNGLDDKTRVSYYSHYLNALLHSIHEDGSVVEGYFAW 440
++I TY+ I +TENG+ +D LDD R Y+ L +I D ++ Y AW
Sbjct: 358 KYIKDTYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKVNLQVYCAW 417
Query: 441 SLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIASRRL 488
SL+DNFEW+ GY SRFGL+ VDFE P + R SAK Y+K+I + L
Sbjct: 418 SLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGL 465
>AK222963-1|BAD96683.1| 469|Homo sapiens cytosolic beta-glucosidase
variant protein.
Length = 469
Score = 380 bits (936), Expect = e-105
Identities = 190/468 (40%), Positives = 275/468 (58%), Gaps = 8/468 (1%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHLYKRD 83
FP F + +TAA Q+EG W+ DGK +WD H+ E V DVA SY L++ D
Sbjct: 3 FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWEED 62
Query: 84 AEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHWD 143
+ + +LG+ YRFS+SW R+LP G T IN+ GI YYN +I+++LK +TP++T+YH+D
Sbjct: 63 LKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKGIDYYNKIIDDLLKNGVTPIVTLYHFD 122
Query: 144 LPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAPA 203
LPQ L+D GGW + I++ + YA+ F FGDRVK WIT NE + Y P
Sbjct: 123 LPQTLEDQGGWLSEAIIESFDKYAQFCFSTFGDRVKQWITINEANVLSVMSYDLGMFPPG 182
Query: 204 LNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEP-KTDTQEDRDA 262
+ G Y HNL+KAHA +H +D +R KG + ++L + W EP ++ D++A
Sbjct: 183 IPHFGTGGYQAAHNLIKAHARSWHSYDSLFRKKQKGMVSLSLFAVWLEPADPNSVSDQEA 242
Query: 263 AELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTTEEVEYIKGTA 322
A+ + H+ +A PI+ +G+YP + + S++Q + SRLP+FT EE + IKGTA
Sbjct: 243 AKRAITFHLDLFAKPIF-IDGDYPEVVKSQIASMSQKQGYPSSRLPEFTEEEKKMIKGTA 301
Query: 323 DFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESSSTWLKVVPYGFRKLL 382
DFF + + TT L+ + + G + Q D I DP+W + W+ VVP+G KLL
Sbjct: 302 DFFAVQYCTTRLIKYQENKRGELGILQ-DAEIEFFPDPSW---KNVDWIYVVPWGVCKLL 357
Query: 383 QWITKTYSGYPIIVTENGY--ADFNGLDDKTRVSYYSHYLNALLHSIHEDGSVVEGYFAW 440
++I TY+ I +TENG+ +D LDD R Y+ L +I D ++ Y AW
Sbjct: 358 KYIKDTYNNPVIYITENGFPQSDPAPLDDTQRWEYFRQTFQELFKAIQLDKVNLQVYCAW 417
Query: 441 SLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIASRRL 488
SL+DNFEW+ GY SRFGL+ VDFE P + R SAK Y+K+I + L
Sbjct: 418 SLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGL 465
>AL161898-1|CAH71888.1| 1012|Homo sapiens klotho protein.
Length = 1012
Score = 305 bits (750), Expect = 2e-82
Identities = 177/484 (36%), Positives = 243/484 (50%), Gaps = 55/484 (11%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNA------------- 70
FP+ F++ V +AA Q EG W GK SIWD H D NA
Sbjct: 61 FPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQPA 120
Query: 71 --DVASDSYHLYKRDAEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEI 128
DVASDSY+ RD E + ELGV YRFS+SW R+LP G N G+ YY L+ +
Sbjct: 121 TGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLERL 180
Query: 129 LKYNITPMITIYHWDLPQKLQDI-GGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEP 187
+ + P++T+YHWDLPQ+LQD GGW+N + D++ DYA++ F++FG +VKYWIT + P
Sbjct: 181 RELGVQPVVTLYHWDLPQRLQDAYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNP 240
Query: 188 MQTCLEGYGGTYRAPALNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDS 247
GY AP + YL HNLL AHA V+HL++ +R G++ IAL S
Sbjct: 241 YVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGQVSIALSS 300
Query: 248 NWAEPKTDTQEDRDAAELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRL 307
+W P+ T + L +GW+A P++ +G+YP ++ +N S L
Sbjct: 301 HWINPRRMTDHSIKECQKSLDFVLGWFAKPVF-IDGDYPESM----------KNNLSSIL 349
Query: 308 PKFTTEEVEYIKGTADFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESS 367
P FT E ++IKGTADFF L T + D + +++ PN
Sbjct: 350 PDFTESEKKFIKGTADFFALCFGPTLSFQLLDPH----------MKFRQLESPN------ 393
Query: 368 STWLKVVPYGFRKLLQWITKTYSGYPIIVTENGY--ADFNGLDDKTRVSYYSHYLNALLH 425
R+LL WI ++ I + ENG+ + DD + Y ++ L
Sbjct: 394 ----------LRQLLSWIDLEFNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLK 443
Query: 426 SIHEDGSVVEGYFAWSLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIAS 485
+I DG V GY AWSLMD FEW GY R GL+ VDF S +K K SA Y K+I
Sbjct: 444 AIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQKLIEK 503
Query: 486 RRLP 489
P
Sbjct: 504 NGFP 507
Score = 217 bits (531), Expect = 6e-56
Identities = 156/493 (31%), Positives = 249/493 (50%), Gaps = 61/493 (12%)
Query: 24 FPENFIFGVSTAAAQIEGAWN-VDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHL--- 79
FP +F +GV Q++ + + +WD VH + +K SY +
Sbjct: 519 FPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWD--VHHSKRLIKVDGVVTKKRKSYCVDFA 576
Query: 80 -YKRDAEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMIT 138
+ ++ E+ V +RFS+ W ILP G +++N + YY + +E+++ NITP++
Sbjct: 577 AIQPQIALLQEMHVTHFRFSLDWALILPLGNQSQVNHTILQYYRCMASELVRVNITPVVA 636
Query: 139 IY-----HWDLPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLE 193
++ + LP+ L G W N + + +YA++ F+ G VK WIT NEP +
Sbjct: 637 LWQPMAPNQGLPRLLARQGAWENPYTALAFAEYARLCFQELGHHVKLWITMNEPYTRNM- 695
Query: 194 GYGGTYRAPALNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEPK 253
TY A HNLLKAHA +H++++++R GKI IAL ++W EP
Sbjct: 696 ----TYSA-------------GHNLLKAHALAWHVYNEKFRHAQNGKISIALQADWIEPA 738
Query: 254 TD-TQEDRDAAELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTT 312
+Q+D++ AE L+ +GW A PI+ + G+YP + ++Q++ NF LP FT
Sbjct: 739 CPFSQKDKEVAERVLEFDIGWLAEPIFGS-GDYPWVMRDWLNQRN---NFL---LPYFTE 791
Query: 313 EEVEYIKGTADFFGLNHYTTYLLTMADKEVGSIPSHQND-VGIVRVQDPNWPSESSSTWL 371
+E + I+GT DF L+HYTT +L ++KE P ND + + + D W + S +
Sbjct: 792 DEKKLIQGTFDFLALSHYTT-ILVDSEKE---DPIKYNDYLEVQEMTDITWLNSPSQ--V 845
Query: 372 KVVPYGFRKLLQWITKTYSGYPIIVTENGYAD-FNGLDDKTRVSYYSHYLNALLHSIHED 430
VVP+G RK+L W+ Y P+ + NG D + DD+ RV Y +Y+N L + D
Sbjct: 846 AVVPWGLRKVLNWLKFKYGDLPMYIISNGIDDGLHAEDDQLRVYYMQNYINEALKAHILD 905
Query: 431 GSVVEGYFAWSLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIASRRLP- 489
G + GYFA+S ++D RFGLY + K S K Y K+I S P
Sbjct: 906 GINLCGYFAYS------FNDRTAPRFGLYRYAADQ----FEPKASMKHYRKIIDSNGFPG 955
Query: 490 ----EDYNPDDFS 498
E + P++F+
Sbjct: 956 PETLERFCPEEFT 968
>AB009667-2|BAA24941.1| 549|Homo sapiens Klotho protein (KL)
protein.
Length = 549
Score = 305 bits (750), Expect = 2e-82
Identities = 177/484 (36%), Positives = 243/484 (50%), Gaps = 55/484 (11%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNA------------- 70
FP+ F++ V +AA Q EG W GK SIWD H D NA
Sbjct: 61 FPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQPA 120
Query: 71 --DVASDSYHLYKRDAEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEI 128
DVASDSY+ RD E + ELGV YRFS+SW R+LP G N G+ YY L+ +
Sbjct: 121 TGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLERL 180
Query: 129 LKYNITPMITIYHWDLPQKLQDI-GGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEP 187
+ + P++T+YHWDLPQ+LQD GGW+N + D++ DYA++ F++FG +VKYWIT + P
Sbjct: 181 RELGVQPVVTLYHWDLPQRLQDAYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNP 240
Query: 188 MQTCLEGYGGTYRAPALNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDS 247
GY AP + YL HNLL AHA V+HL++ +R G++ IAL S
Sbjct: 241 YVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGQVSIALSS 300
Query: 248 NWAEPKTDTQEDRDAAELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRL 307
+W P+ T + L +GW+A P++ +G+YP ++ +N S L
Sbjct: 301 HWINPRRMTDHSIKECQKSLDFVLGWFAKPVF-IDGDYPESM----------KNNLSSIL 349
Query: 308 PKFTTEEVEYIKGTADFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESS 367
P FT E ++IKGTADFF L T + D + +++ PN
Sbjct: 350 PDFTESEKKFIKGTADFFALCFGPTLSFQLLDPH----------MKFRQLESPN------ 393
Query: 368 STWLKVVPYGFRKLLQWITKTYSGYPIIVTENGY--ADFNGLDDKTRVSYYSHYLNALLH 425
R+LL WI ++ I + ENG+ + DD + Y ++ L
Sbjct: 394 ----------LRQLLSWIDLEFNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLK 443
Query: 426 SIHEDGSVVEGYFAWSLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIAS 485
+I DG V GY AWSLMD FEW GY R GL+ VDF S +K K SA Y K+I
Sbjct: 444 AIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQKLIEK 503
Query: 486 RRLP 489
P
Sbjct: 504 NGFP 507
>AB009667-1|BAA24940.1| 1012|Homo sapiens Klotho protein (KL)
protein.
Length = 1012
Score = 305 bits (750), Expect = 2e-82
Identities = 177/484 (36%), Positives = 243/484 (50%), Gaps = 55/484 (11%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNA------------- 70
FP+ F++ V +AA Q EG W GK SIWD H D NA
Sbjct: 61 FPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQPA 120
Query: 71 --DVASDSYHLYKRDAEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEI 128
DVASDSY+ RD E + ELGV YRFS+SW R+LP G N G+ YY L+ +
Sbjct: 121 TGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLERL 180
Query: 129 LKYNITPMITIYHWDLPQKLQDI-GGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEP 187
+ + P++T+YHWDLPQ+LQD GGW+N + D++ DYA++ F++FG +VKYWIT + P
Sbjct: 181 RELGVQPVVTLYHWDLPQRLQDAYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNP 240
Query: 188 MQTCLEGYGGTYRAPALNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDS 247
GY AP + YL HNLL AHA V+HL++ +R G++ IAL S
Sbjct: 241 YVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGQVSIALSS 300
Query: 248 NWAEPKTDTQEDRDAAELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRL 307
+W P+ T + L +GW+A P++ +G+YP ++ +N S L
Sbjct: 301 HWINPRRMTDHSIKECQKSLDFVLGWFAKPVF-IDGDYPESM----------KNNLSSIL 349
Query: 308 PKFTTEEVEYIKGTADFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESS 367
P FT E ++IKGTADFF L T + D + +++ PN
Sbjct: 350 PDFTESEKKFIKGTADFFALCFGPTLSFQLLDPH----------MKFRQLESPN------ 393
Query: 368 STWLKVVPYGFRKLLQWITKTYSGYPIIVTENGY--ADFNGLDDKTRVSYYSHYLNALLH 425
R+LL WI ++ I + ENG+ + DD + Y ++ L
Sbjct: 394 ----------LRQLLSWIDLEFNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLK 443
Query: 426 SIHEDGSVVEGYFAWSLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIAS 485
+I DG V GY AWSLMD FEW GY R GL+ VDF S +K K SA Y K+I
Sbjct: 444 AIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQKLIEK 503
Query: 486 RRLP 489
P
Sbjct: 504 NGFP 507
Score = 217 bits (531), Expect = 6e-56
Identities = 156/493 (31%), Positives = 249/493 (50%), Gaps = 61/493 (12%)
Query: 24 FPENFIFGVSTAAAQIEGAWN-VDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHL--- 79
FP +F +GV Q++ + + +WD VH + +K SY +
Sbjct: 519 FPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWD--VHHSKRLIKVDGVVTKKRKSYCVDFA 576
Query: 80 -YKRDAEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMIT 138
+ ++ E+ V +RFS+ W ILP G +++N + YY + +E+++ NITP++
Sbjct: 577 AIQPQIALLQEMHVTHFRFSLDWALILPLGNQSQVNHTILQYYRCMASELVRVNITPVVA 636
Query: 139 IY-----HWDLPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLE 193
++ + LP+ L G W N + + +YA++ F+ G VK WIT NEP +
Sbjct: 637 LWQPMAPNQGLPRLLARQGAWENPYTALAFAEYARLCFQELGHHVKLWITMNEPYTRNM- 695
Query: 194 GYGGTYRAPALNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEPK 253
TY A HNLLKAHA +H++++++R GKI IAL ++W EP
Sbjct: 696 ----TYSA-------------GHNLLKAHALAWHVYNEKFRHAQNGKISIALQADWIEPA 738
Query: 254 TD-TQEDRDAAELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTT 312
+Q+D++ AE L+ +GW A PI+ + G+YP + ++Q++ NF LP FT
Sbjct: 739 CPFSQKDKEVAERVLEFDIGWLAEPIFGS-GDYPWVMRDWLNQRN---NFL---LPYFTE 791
Query: 313 EEVEYIKGTADFFGLNHYTTYLLTMADKEVGSIPSHQND-VGIVRVQDPNWPSESSSTWL 371
+E + I+GT DF L+HYTT +L ++KE P ND + + + D W + S +
Sbjct: 792 DEKKLIQGTFDFLALSHYTT-ILVDSEKE---DPIKYNDYLEVQEMTDITWLNSPSQ--V 845
Query: 372 KVVPYGFRKLLQWITKTYSGYPIIVTENGYAD-FNGLDDKTRVSYYSHYLNALLHSIHED 430
VVP+G RK+L W+ Y P+ + NG D + DD+ RV Y +Y+N L + D
Sbjct: 846 AVVPWGLRKVLNWLKFKYGDLPMYIISNGIDDGLHAEDDQLRVYYMQNYINEALKAHILD 905
Query: 431 GSVVEGYFAWSLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIASRRLP- 489
G + GYFA+S ++D RFGLY + K S K Y K+I S P
Sbjct: 906 GINLCGYFAYS------FNDRTAPRFGLYRYAADQ----FEPKASMKHYRKIIDSNGFPG 955
Query: 490 ----EDYNPDDFS 498
E + P++F+
Sbjct: 956 PETLERFCPEEFT 968
>AB005142-1|BAA23382.1| 1012|Homo sapiens klotho protein.
Length = 1012
Score = 305 bits (750), Expect = 2e-82
Identities = 177/484 (36%), Positives = 243/484 (50%), Gaps = 55/484 (11%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNA------------- 70
FP+ F++ V +AA Q EG W GK SIWD H D NA
Sbjct: 61 FPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQPA 120
Query: 71 --DVASDSYHLYKRDAEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEI 128
DVASDSY+ RD E + ELGV YRFS+SW R+LP G N G+ YY L+ +
Sbjct: 121 TGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLERL 180
Query: 129 LKYNITPMITIYHWDLPQKLQDI-GGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEP 187
+ + P++T+YHWDLPQ+LQD GGW+N + D++ DYA++ F++FG +VKYWIT + P
Sbjct: 181 RELGVQPVVTLYHWDLPQRLQDAYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNP 240
Query: 188 MQTCLEGYGGTYRAPALNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDS 247
GY AP + YL HNLL AHA V+HL++ +R G++ IAL S
Sbjct: 241 YVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGQVSIALSS 300
Query: 248 NWAEPKTDTQEDRDAAELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRL 307
+W P+ T + L +GW+A P++ +G+YP ++ +N S L
Sbjct: 301 HWINPRRMTDHSIKECQKSLDFVLGWFAKPVF-IDGDYPESM----------KNNLSSIL 349
Query: 308 PKFTTEEVEYIKGTADFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESS 367
P FT E ++IKGTADFF L T + D + +++ PN
Sbjct: 350 PDFTESEKKFIKGTADFFALCFGPTLSFQLLDPH----------MKFRQLESPN------ 393
Query: 368 STWLKVVPYGFRKLLQWITKTYSGYPIIVTENGY--ADFNGLDDKTRVSYYSHYLNALLH 425
R+LL WI ++ I + ENG+ + DD + Y ++ L
Sbjct: 394 ----------LRQLLSWIDLEFNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLK 443
Query: 426 SIHEDGSVVEGYFAWSLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIAS 485
+I DG V GY AWSLMD FEW GY R GL+ VDF S +K K SA Y K+I
Sbjct: 444 AIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQKLIEK 503
Query: 486 RRLP 489
P
Sbjct: 504 NGFP 507
Score = 217 bits (531), Expect = 6e-56
Identities = 156/493 (31%), Positives = 249/493 (50%), Gaps = 61/493 (12%)
Query: 24 FPENFIFGVSTAAAQIEGAWN-VDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHL--- 79
FP +F +GV Q++ + + +WD VH + +K SY +
Sbjct: 519 FPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWD--VHHSKRLIKVDGVVTKKRKSYCVDFA 576
Query: 80 -YKRDAEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMIT 138
+ ++ E+ V +RFS+ W ILP G +++N + YY + +E+++ NITP++
Sbjct: 577 AIQPQIALLQEMHVTHFRFSLDWALILPLGNQSQVNHTILQYYRCMASELVRVNITPVVA 636
Query: 139 IY-----HWDLPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLE 193
++ + LP+ L G W N + + +YA++ F+ G VK WIT NEP +
Sbjct: 637 LWQPMAPNQGLPRLLARQGAWENPYTALAFAEYARLCFQELGHHVKLWITMNEPYTRNM- 695
Query: 194 GYGGTYRAPALNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEPK 253
TY A HNLLKAHA +H++++++R GKI IAL ++W EP
Sbjct: 696 ----TYSA-------------GHNLLKAHALAWHVYNEKFRHAQNGKISIALQADWIEPA 738
Query: 254 TD-TQEDRDAAELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTT 312
+Q+D++ AE L+ +GW A PI+ + G+YP + ++Q++ NF LP FT
Sbjct: 739 CPFSQKDKEVAERVLEFDIGWLAEPIFGS-GDYPWVMRDWLNQRN---NFL---LPYFTE 791
Query: 313 EEVEYIKGTADFFGLNHYTTYLLTMADKEVGSIPSHQND-VGIVRVQDPNWPSESSSTWL 371
+E + I+GT DF L+HYTT +L ++KE P ND + + + D W + S +
Sbjct: 792 DEKKLIQGTFDFLALSHYTT-ILVDSEKE---DPIKYNDYLEVQEMTDITWLNSPSQ--V 845
Query: 372 KVVPYGFRKLLQWITKTYSGYPIIVTENGYAD-FNGLDDKTRVSYYSHYLNALLHSIHED 430
VVP+G RK+L W+ Y P+ + NG D + DD+ RV Y +Y+N L + D
Sbjct: 846 AVVPWGLRKVLNWLKFKYGDLPMYIISNGIDDGLHAEDDQLRVYYMQNYINEALKAHILD 905
Query: 431 GSVVEGYFAWSLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIASRRLP- 489
G + GYFA+S ++D RFGLY + K S K Y K+I S P
Sbjct: 906 GINLCGYFAYS------FNDRTAPRFGLYRYAADQ----FEPKASMKHYRKIIDSNGFPG 955
Query: 490 ----EDYNPDDFS 498
E + P++F+
Sbjct: 956 PETLERFCPEEFT 968
>BC113653-1|AAI13654.1| 1044|Homo sapiens klotho beta protein.
Length = 1044
Score = 292 bits (716), Expect = 2e-78
Identities = 164/463 (35%), Positives = 247/463 (53%), Gaps = 43/463 (9%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHLYKRD 83
FP+NF +G+ T A Q+EG+W DGK SIWDH +H + +K+ S+ + +SDSY ++D
Sbjct: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTH---LKNVSSTNGSSDSYIFLEKD 137
Query: 84 AEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHWD 143
+ +GV Y+FS+SWPR+ P G+ N G+ YY+ L++ ++ NI P++T+YHWD
Sbjct: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197
Query: 144 LPQKLQD-IGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAP 202
LP LQ+ GGW N I+D + DYA F+ FGDRVKYWIT + P GYG AP
Sbjct: 198 LPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAP 257
Query: 203 ALNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEP-KTDTQEDRD 261
+ A Y HNL+KAH+ V+H ++ +R KG + I L S+W EP +++ D
Sbjct: 258 GEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIF 317
Query: 262 AAELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTTEEVEYIKGT 321
+ + + +GW+A+PI+ +G+YP + K + S LP F+ E ++GT
Sbjct: 318 KCQQSMVSVLGWFANPIH-GDGDYPEGMRKKL----------FSVLPIFSEAEKHEMRGT 366
Query: 322 ADFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNW-PSESSSTWLKVVPYGFRK 380
ADFF + K + ++ +V + + NW E ++ + + G
Sbjct: 367 ADFFAFSFGPNNF-----KPLNTMAKMGQNVSLNLREALNWIKLEYNNPRILIAENG--- 418
Query: 381 LLQWITKTYSGYPIIVTENGYADFNGLDDKTRVSYYSHYLNALLHSIHEDGSVVEGYFAW 440
W T + + TE D T + ++L+ +L +I D V GY AW
Sbjct: 419 ---WFTDSR-----VKTE----------DTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAW 460
Query: 441 SLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVI 483
SL+D FEW D Y R GL+ VDF S K R K SA Y ++I
Sbjct: 461 SLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQII 503
Score = 236 bits (578), Expect = 1e-61
Identities = 154/480 (32%), Positives = 248/480 (51%), Gaps = 44/480 (9%)
Query: 23 KFPENFIFGVSTAAAQIEGAWNVDGKSES---IWD----HLVHKNPEFVKDGSNADVASD 75
+FP +F +GV+ + + E + S+ +W+ L+H+ E V+ + +D
Sbjct: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHR-VEGVRLKTRPAQCTD 578
Query: 76 SYHLYKRDAEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITP 135
++ K+ EM+ + V YRF++ W +LPTG + +N + YY +++E LK I+
Sbjct: 579 FVNI-KKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISA 637
Query: 136 MITIY-----HWDLPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQT 190
M+T+Y H LP+ L GW N + + YA + F+ GD VK WIT NEP +
Sbjct: 638 MVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRL 697
Query: 191 CLEGYGGTYRAPALNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWA 250
+ NR G+ Y HNLL AHA + L+D+++R +G + ++L ++WA
Sbjct: 698 ----------SDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWA 747
Query: 251 EPKTDTQEDR-DAAELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPK 309
EP + AAE +LQ + W+A P++ G+YP A+ + + K + + + S LP+
Sbjct: 748 EPANPYADSHWRAAERFLQFEIAWFAEPLFKT-GDYPAAMREYIASKHR-RGLSSSALPR 805
Query: 310 FTTEEVEYIKGTADFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESSST 369
T E +KGT DF LNH+TT + M ++ GS + +D I +QD SS T
Sbjct: 806 LTEAERRLLKGTVDFCALNHFTTRFV-MHEQLAGS--RYDSDRDIQFLQDIT--RLSSPT 860
Query: 370 WLKVVPYGFRKLLQWITKTYSGYPIIVTENGYADFNGLDDKTRVSYYSHYLNALLHSIHE 429
L V+P+G RKLL+W+ + Y I +T +G D DD+ R Y YL +L +
Sbjct: 861 RLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLI 920
Query: 430 DGSVVEGYFAWSLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIASRRLP 489
D ++GY+A+ L ++ RFG + DF+ AK S + Y+KVI+SR P
Sbjct: 921 DKVRIKGYYAFKLA-----EEKSKPRFGFFTSDFK-------AKSSIQFYNKVISSRGFP 968
>BC104871-1|AAI04872.1| 1044|Homo sapiens klotho beta protein.
Length = 1044
Score = 292 bits (716), Expect = 2e-78
Identities = 164/463 (35%), Positives = 247/463 (53%), Gaps = 43/463 (9%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHLYKRD 83
FP+NF +G+ T A Q+EG+W DGK SIWDH +H + +K+ S+ + +SDSY ++D
Sbjct: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTH---LKNVSSTNGSSDSYIFLEKD 137
Query: 84 AEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHWD 143
+ +GV Y+FS+SWPR+ P G+ N G+ YY+ L++ ++ NI P++T+YHWD
Sbjct: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197
Query: 144 LPQKLQD-IGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAP 202
LP LQ+ GGW N I+D + DYA F+ FGDRVKYWIT + P GYG AP
Sbjct: 198 LPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAP 257
Query: 203 ALNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEP-KTDTQEDRD 261
+ A Y HNL+KAH+ V+H ++ +R KG + I L S+W EP +++ D
Sbjct: 258 GEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIF 317
Query: 262 AAELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTTEEVEYIKGT 321
+ + + +GW+A+PI+ +G+YP + K + S LP F+ E ++GT
Sbjct: 318 KCQQSMVSVLGWFANPIH-GDGDYPEGMRKKL----------FSVLPIFSEAEKHEMRGT 366
Query: 322 ADFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNW-PSESSSTWLKVVPYGFRK 380
ADFF + K + ++ +V + + NW E ++ + + G
Sbjct: 367 ADFFAFSFGPNNF-----KPLNTMAKMGQNVSLNLREALNWIKLEYNNPRILIAENG--- 418
Query: 381 LLQWITKTYSGYPIIVTENGYADFNGLDDKTRVSYYSHYLNALLHSIHEDGSVVEGYFAW 440
W T + + TE D T + ++L+ +L +I D V GY AW
Sbjct: 419 ---WFTDSR-----VKTE----------DTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAW 460
Query: 441 SLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVI 483
SL+D FEW D Y R GL+ VDF S K R K SA Y ++I
Sbjct: 461 SLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQII 503
Score = 236 bits (578), Expect = 1e-61
Identities = 154/480 (32%), Positives = 248/480 (51%), Gaps = 44/480 (9%)
Query: 23 KFPENFIFGVSTAAAQIEGAWNVDGKSES---IWD----HLVHKNPEFVKDGSNADVASD 75
+FP +F +GV+ + + E + S+ +W+ L+H+ E V+ + +D
Sbjct: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHR-VEGVRLKTRPAQCTD 578
Query: 76 SYHLYKRDAEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITP 135
++ K+ EM+ + V YRF++ W +LPTG + +N + YY +++E LK I+
Sbjct: 579 FVNI-KKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISA 637
Query: 136 MITIY-----HWDLPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQT 190
M+T+Y H LP+ L GW N + + YA + F+ GD VK WIT NEP +
Sbjct: 638 MVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRL 697
Query: 191 CLEGYGGTYRAPALNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWA 250
+ NR G+ Y HNLL AHA + L+D+++R +G + ++L ++WA
Sbjct: 698 ----------SDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWA 747
Query: 251 EPKTDTQEDR-DAAELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPK 309
EP + AAE +LQ + W+A P++ G+YP A+ + + K + + + S LP+
Sbjct: 748 EPANPYADSHWRAAERFLQFEIAWFAEPLFKT-GDYPAAMREYIASKHR-RGLSSSALPR 805
Query: 310 FTTEEVEYIKGTADFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESSST 369
T E +KGT DF LNH+TT + M ++ GS + +D I +QD SS T
Sbjct: 806 LTEAERRLLKGTVDFCALNHFTTRFV-MHEQLAGS--RYDSDRDIQFLQDIT--RLSSPT 860
Query: 370 WLKVVPYGFRKLLQWITKTYSGYPIIVTENGYADFNGLDDKTRVSYYSHYLNALLHSIHE 429
L V+P+G RKLL+W+ + Y I +T +G D DD+ R Y YL +L +
Sbjct: 861 RLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLI 920
Query: 430 DGSVVEGYFAWSLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIASRRLP 489
D ++GY+A+ L ++ RFG + DF+ AK S + Y+KVI+SR P
Sbjct: 921 DKVRIKGYYAFKLA-----EEKSKPRFGFFTSDFK-------AKSSIQFYNKVISSRGFP 968
>AB079373-1|BAC56857.1| 1044|Homo sapiens klotho beta like protein
protein.
Length = 1044
Score = 292 bits (716), Expect = 2e-78
Identities = 164/463 (35%), Positives = 247/463 (53%), Gaps = 43/463 (9%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHLYKRD 83
FP+NF +G+ T A Q+EG+W DGK SIWDH +H + +K+ S+ + +SDSY ++D
Sbjct: 81 FPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTH---LKNVSSTNGSSDSYIFLEKD 137
Query: 84 AEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMITIYHWD 143
+ +GV Y+FS+SWPR+ P G+ N G+ YY+ L++ ++ NI P++T+YHWD
Sbjct: 138 LSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWD 197
Query: 144 LPQKLQD-IGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLEGYGGTYRAP 202
LP LQ+ GGW N I+D + DYA F+ FGDRVKYWIT + P GYG AP
Sbjct: 198 LPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAP 257
Query: 203 ALNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEP-KTDTQEDRD 261
+ A Y HNL+KAH+ V+H ++ +R KG + I L S+W EP +++ D
Sbjct: 258 GEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIF 317
Query: 262 AAELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTTEEVEYIKGT 321
+ + + +GW+A+PI+ +G+YP + K + S LP F+ E ++GT
Sbjct: 318 KCQQSMVSVLGWFANPIH-GDGDYPEGMRKKL----------FSVLPIFSEAEKHEMRGT 366
Query: 322 ADFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNW-PSESSSTWLKVVPYGFRK 380
ADFF + K + ++ +V + + NW E ++ + + G
Sbjct: 367 ADFFAFSFGPNNF-----KPLNTMAKMGQNVSLNLREALNWIKLEYNNPRILIAENG--- 418
Query: 381 LLQWITKTYSGYPIIVTENGYADFNGLDDKTRVSYYSHYLNALLHSIHEDGSVVEGYFAW 440
W T + + TE D T + ++L+ +L +I D V GY AW
Sbjct: 419 ---WFTDSR-----VKTE----------DTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAW 460
Query: 441 SLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVI 483
SL+D FEW D Y R GL+ VDF S K R K SA Y ++I
Sbjct: 461 SLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQII 503
Score = 236 bits (578), Expect = 1e-61
Identities = 154/480 (32%), Positives = 248/480 (51%), Gaps = 44/480 (9%)
Query: 23 KFPENFIFGVSTAAAQIEGAWNVDGKSES---IWD----HLVHKNPEFVKDGSNADVASD 75
+FP +F +GV+ + + E + S+ +W+ L+H+ E V+ + +D
Sbjct: 520 QFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHR-VEGVRLKTRPAQCTD 578
Query: 76 SYHLYKRDAEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITP 135
++ K+ EM+ + V YRF++ W +LPTG + +N + YY +++E LK I+
Sbjct: 579 FVNI-KKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISA 637
Query: 136 MITIY-----HWDLPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQT 190
M+T+Y H LP+ L GW N + + YA + F+ GD VK WIT NEP +
Sbjct: 638 MVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRL 697
Query: 191 CLEGYGGTYRAPALNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWA 250
+ NR G+ Y HNLL AHA + L+D+++R +G + ++L ++WA
Sbjct: 698 ----------SDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWA 747
Query: 251 EPKTDTQEDR-DAAELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPK 309
EP + AAE +LQ + W+A P++ G+YP A+ + + K + + + S LP+
Sbjct: 748 EPANPYADSHWRAAERFLQFEIAWFAEPLFKT-GDYPAAMREYIASKHR-RGLSSSALPR 805
Query: 310 FTTEEVEYIKGTADFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWPSESSST 369
T E +KGT DF LNH+TT + M ++ GS + +D I +QD SS T
Sbjct: 806 LTEAERRLLKGTVDFCALNHFTTRFV-MHEQLAGS--RYDSDRDIQFLQDIT--RLSSPT 860
Query: 370 WLKVVPYGFRKLLQWITKTYSGYPIIVTENGYADFNGLDDKTRVSYYSHYLNALLHSIHE 429
L V+P+G RKLL+W+ + Y I +T +G D DD+ R Y YL +L +
Sbjct: 861 RLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLI 920
Query: 430 DGSVVEGYFAWSLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIASRRLP 489
D ++GY+A+ L ++ RFG + DF+ AK S + Y+KVI+SR P
Sbjct: 921 DKVRIKGYYAFKLA-----EEKSKPRFGFFTSDFK-------AKSSIQFYNKVISSRGFP 968
>Z84483-1|CAC94773.1| 739|Homo sapiens 46H23.1 (Klotho) protein.
Length = 739
Score = 217 bits (531), Expect = 6e-56
Identities = 156/493 (31%), Positives = 249/493 (50%), Gaps = 61/493 (12%)
Query: 24 FPENFIFGVSTAAAQIEGAWN-VDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHL--- 79
FP +F +GV Q++ + + +WD VH + +K SY +
Sbjct: 246 FPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWD--VHHSKRLIKVDGVVTKKRKSYCVDFA 303
Query: 80 -YKRDAEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEILKYNITPMIT 138
+ ++ E+ V +RFS+ W ILP G +++N + YY + +E+++ NITP++
Sbjct: 304 AIQPQIALLQEMHVTHFRFSLDWALILPLGNQSQVNHTILQYYRCMASELVRVNITPVVA 363
Query: 139 IY-----HWDLPQKLQDIGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEPMQTCLE 193
++ + LP+ L G W N + + +YA++ F+ G VK WIT NEP +
Sbjct: 364 LWQPMAPNQGLPRLLARQGAWENPYTALAFAEYARLCFQELGHHVKLWITMNEPYTRNM- 422
Query: 194 GYGGTYRAPALNRHGHAEYLCTHNLLKAHANVYHLFDKEYRTVNKGKIGIALDSNWAEPK 253
TY A HNLLKAHA +H++++++R GKI IAL ++W EP
Sbjct: 423 ----TYSA-------------GHNLLKAHALAWHVYNEKFRHAQNGKISIALQADWIEPA 465
Query: 254 TD-TQEDRDAAELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFTRSRLPKFTT 312
+Q+D++ AE L+ +GW A PI+ + G+YP + ++Q++ NF LP FT
Sbjct: 466 CPFSQKDKEVAERVLEFDIGWLAEPIFGS-GDYPWVMRDWLNQRN---NFL---LPYFTE 518
Query: 313 EEVEYIKGTADFFGLNHYTTYLLTMADKEVGSIPSHQND-VGIVRVQDPNWPSESSSTWL 371
+E + I+GT DF L+HYTT +L ++KE P ND + + + D W + S +
Sbjct: 519 DEKKLIQGTFDFLALSHYTT-ILVDSEKE---DPIKYNDYLEVQEMTDITWLNSPSQ--V 572
Query: 372 KVVPYGFRKLLQWITKTYSGYPIIVTENGYAD-FNGLDDKTRVSYYSHYLNALLHSIHED 430
VVP+G RK+L W+ Y P+ + NG D + DD+ RV Y +Y+N L + D
Sbjct: 573 AVVPWGLRKVLNWLKFKYGDLPMYIISNGIDDGLHAEDDQLRVYYMQNYINEALKAHILD 632
Query: 431 GSVVEGYFAWSLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIASRRLP- 489
G + GYFA+S ++D RFGLY + K S K Y K+I S P
Sbjct: 633 GINLCGYFAYS------FNDRTAPRFGLYRYAADQ----FEPKASMKHYRKIIDSNGFPG 682
Query: 490 ----EDYNPDDFS 498
E + P++F+
Sbjct: 683 PETLERFCPEEFT 695
Score = 129 bits (311), Expect = 3e-29
Identities = 88/271 (32%), Positives = 126/271 (46%), Gaps = 39/271 (14%)
Query: 221 AHANVYHLFDKEYRTVNKGKIGIALDSNWAEPKTDTQEDRDAAELYLQTHVGWYAHPIYS 280
AHA V+HL++ +R G++ IAL S+W P+ T + L +GW+A P++
Sbjct: 1 AHAKVWHLYNTSFRPTQGGQVSIALSSHWINPRRMTDHSIKECQKSLDFVLGWFAKPVF- 59
Query: 281 AEGNYPPALIKLVDQKSKEQNFTRSRLPKFTTEEVEYIKGTADFFGLNHYTTYLLTMADK 340
+G+YP ++ +N S LP FT E ++IKGTADFF L T + D
Sbjct: 60 IDGDYPESM----------KNNLSSILPDFTESEKKFIKGTADFFALCFGPTLSFQLLDP 109
Query: 341 EVGSIPSHQNDVGIVRVQDPNWPSESSSTWLKVVPYGFRKLLQWITKTYSGYPIIVTENG 400
+ +++ PN R+LL WI ++ I + ENG
Sbjct: 110 HMK----------FRQLESPN----------------LRQLLSWIDLEFNHPQIFIVENG 143
Query: 401 Y--ADFNGLDDKTRVSYYSHYLNALLHSIHEDGSVVEGYFAWSLMDNFEWDDGYVSRFGL 458
+ + DD + Y ++ L +I DG V GY AWSLMD FEW GY R GL
Sbjct: 144 WFVSGTTKRDDAKYMYYLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGL 203
Query: 459 YLVDFESPNKTRTAKDSAKLYSKVIASRRLP 489
+ VDF S +K K SA Y K+I P
Sbjct: 204 FYVDFLSQDKMLLPKSSALFYQKLIEKNGFP 234
>Z92540-2|CAC94767.1| 273|Homo sapiens 179I15.1 (klotho) protein.
Length = 273
Score = 181 bits (441), Expect = 5e-45
Identities = 89/212 (41%), Positives = 117/212 (55%), Gaps = 16/212 (7%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNA------------- 70
FP+ F++ V +AA Q EG W GK SIWD H D NA
Sbjct: 61 FPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQPA 120
Query: 71 --DVASDSYHLYKRDAEMVHELGVDTYRFSVSWPRILPTGLTNEINELGIAYYNNLINEI 128
DVASDSY+ RD E + ELGV YRFS+SW R+LP G N G+ YY L+ +
Sbjct: 121 TGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLERL 180
Query: 129 LKYNITPMITIYHWDLPQKLQD-IGGWSNAHIVDYYTDYAKILFKNFGDRVKYWITFNEP 187
+ + P++T+YHWDLPQ+LQD GGW+N + D++ DYA++ F++FG +VKYWIT + P
Sbjct: 181 RELGVQPVVTLYHWDLPQRLQDAYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNP 240
Query: 188 MQTCLEGYGGTYRAPALNRHGHAEYLCTHNLL 219
GY AP + YL HNLL
Sbjct: 241 YVVAWHGYATGRLAPGIRGSPRLGYLVAHNLL 272
>BC033021-1|AAH33021.1| 305|Homo sapiens KLB protein protein.
Length = 305
Score = 126 bits (305), Expect = 1e-28
Identities = 84/246 (34%), Positives = 129/246 (52%), Gaps = 20/246 (8%)
Query: 245 LDSNWAEPKTDTQEDR-DAAELYLQTHVGWYAHPIYSAEGNYPPALIKLVDQKSKEQNFT 303
L ++WAEP + AAE +LQ + W+A P++ G+YP A+ + + K + + +
Sbjct: 3 LHADWAEPANLYADSHWRAAERFLQFEIAWFAEPLFKT-GDYPAAMREYIASKHR-RGLS 60
Query: 304 RSRLPKFTTEEVEYIKGTADFFGLNHYTTYLLTMADKEVGSIPSHQNDVGIVRVQDPNWP 363
S LP+ T E +KGT DF LNH+TT + M ++ GS + +D I +QD
Sbjct: 61 SSALPRLTEAERRLLKGTVDFCALNHFTTRFV-MHEQLAGS--RYDSDRDIQFLQDIT-- 115
Query: 364 SESSSTWLKVVPYGFRKLLQWITKTYSGYPIIVTENGYADFNGLDDKTRVSYYSHYLNAL 423
SS T L V+P+G RKLL+W+ + Y I +T +G D DD+ R Y YL +
Sbjct: 116 RLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEV 175
Query: 424 LHSIHEDGSVVEGYFAWSLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVI 483
L + D ++GY+A+ L ++ RFG + DF+ AK S + Y+KVI
Sbjct: 176 LKAYLIDKVRIKGYYAFKLA-----EEKSKPRFGFFTSDFK-------AKSSIQFYNKVI 223
Query: 484 ASRRLP 489
+SR P
Sbjct: 224 SSRGFP 229
>BC109377-1|AAI09378.1| 162|Homo sapiens GBA3 protein protein.
Length = 162
Score = 92.7 bits (220), Expect = 3e-18
Identities = 41/95 (43%), Positives = 56/95 (58%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHLYKRD 83
FP F + +TAA Q+EG W+ DGK +WD H+ E V DVA SY L++ D
Sbjct: 3 FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWEED 62
Query: 84 AEMVHELGVDTYRFSVSWPRILPTGLTNEINELGI 118
+ + +LG+ YRFS+SW R+LP G T IN+ I
Sbjct: 63 LKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKAI 97
Score = 69.3 bits (162), Expect = 3e-11
Identities = 32/63 (50%), Positives = 42/63 (66%)
Query: 426 SIHEDGSVVEGYFAWSLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIAS 485
+I D ++ Y AWSL+DNFEW+ GY SRFGL+ VDFE P + R SAK Y+K+I +
Sbjct: 96 AIQLDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRN 155
Query: 486 RRL 488
L
Sbjct: 156 NGL 158
>BC029362-1|AAH29362.1| 162|Homo sapiens GBA3 protein protein.
Length = 162
Score = 92.7 bits (220), Expect = 3e-18
Identities = 41/95 (43%), Positives = 56/95 (58%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHLYKRD 83
FP F + +TAA Q+EG W+ DGK +WD H+ E V DVA SY L++ D
Sbjct: 3 FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVFKNQTGDVACGSYTLWEED 62
Query: 84 AEMVHELGVDTYRFSVSWPRILPTGLTNEINELGI 118
+ + +LG+ YRFS+SW R+LP G T IN+ I
Sbjct: 63 LKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKAI 97
Score = 69.3 bits (162), Expect = 3e-11
Identities = 32/63 (50%), Positives = 42/63 (66%)
Query: 426 SIHEDGSVVEGYFAWSLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIAS 485
+I D ++ Y AWSL+DNFEW+ GY SRFGL+ VDFE P + R SAK Y+K+I +
Sbjct: 96 AIQLDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRN 155
Query: 486 RRL 488
L
Sbjct: 156 NGL 158
>BC070188-1|AAH70188.1| 162|Homo sapiens GBA3 protein protein.
Length = 162
Score = 91.9 bits (218), Expect = 5e-18
Identities = 41/95 (43%), Positives = 56/95 (58%)
Query: 24 FPENFIFGVSTAAAQIEGAWNVDGKSESIWDHLVHKNPEFVKDGSNADVASDSYHLYKRD 83
FP F + +TAA Q+EG W+ DGK +WD H+ E V DVA SY L++ D
Sbjct: 3 FPAGFGWAAATAAYQVEGGWDADGKGLCVWDTFTHQGGERVFKNQTGDVACGSYTLWEED 62
Query: 84 AEMVHELGVDTYRFSVSWPRILPTGLTNEINELGI 118
+ + +LG+ YRFS+SW R+LP G T IN+ I
Sbjct: 63 LKCIKQLGLTHYRFSLSWSRLLPDGTTGFINQKAI 97
Score = 69.3 bits (162), Expect = 3e-11
Identities = 32/63 (50%), Positives = 42/63 (66%)
Query: 426 SIHEDGSVVEGYFAWSLMDNFEWDDGYVSRFGLYLVDFESPNKTRTAKDSAKLYSKVIAS 485
+I D ++ Y AWSL+DNFEW+ GY SRFGL+ VDFE P + R SAK Y+K+I +
Sbjct: 96 AIQLDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRN 155
Query: 486 RRL 488
L
Sbjct: 156 NGL 158
>U33837-1|AAB41649.1| 4655|Homo sapiens gp330 precursor protein.
Length = 4655
Score = 35.1 bits (77), Expect = 0.61
Identities = 18/39 (46%), Positives = 24/39 (61%)
Query: 394 IIVTENGYADFNGLDDKTRVSYYSHYLNALLHSIHEDGS 432
+I + G AD D TR YYS YLN +++S+ EDGS
Sbjct: 2460 VIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGS 2498
>AY265358-1|AAP88586.1| 4655|Homo sapiens glycoprotein receptor
gp330/megalin precursor protein.
Length = 4655
Score = 35.1 bits (77), Expect = 0.61
Identities = 18/39 (46%), Positives = 24/39 (61%)
Query: 394 IIVTENGYADFNGLDDKTRVSYYSHYLNALLHSIHEDGS 432
+I + G AD D TR YYS YLN +++S+ EDGS
Sbjct: 2460 VIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGS 2498
>AY265357-1|AAP88585.1| 4655|Homo sapiens glycoprotein receptor
gp330/megalin precursor protein.
Length = 4655
Score = 35.1 bits (77), Expect = 0.61
Identities = 18/39 (46%), Positives = 24/39 (61%)
Query: 394 IIVTENGYADFNGLDDKTRVSYYSHYLNALLHSIHEDGS 432
+I + G AD D TR YYS YLN +++S+ EDGS
Sbjct: 2460 VIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGS 2498
>AC007556-2|AAX88965.1| 3881|Homo sapiens unknown protein.
Length = 3881
Score = 35.1 bits (77), Expect = 0.61
Identities = 18/39 (46%), Positives = 24/39 (61%)
Query: 394 IIVTENGYADFNGLDDKTRVSYYSHYLNALLHSIHEDGS 432
+I + G AD D TR YYS YLN +++S+ EDGS
Sbjct: 1686 VIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGS 1724
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.319 0.136 0.429
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 85,541,524
Number of Sequences: 224733
Number of extensions: 3769643
Number of successful extensions: 8662
Number of sequences better than 10.0: 28
Number of HSP's better than 10.0 without gapping: 28
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 8428
Number of HSP's gapped (non-prelim): 72
length of query: 523
length of database: 73,234,838
effective HSP length: 93
effective length of query: 430
effective length of database: 52,334,669
effective search space: 22503907670
effective search space used: 22503907670
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 67 (31.1 bits)
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